Search of human proteins with 115529482

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo
sapiens]
         (858 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sap...  1727   0.0  
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi...  1697   0.0  
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap...  1383   0.0  
gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapi...   705   0.0  
gi|118572606 hemicentin 1 [Homo sapiens]                              164   2e-40
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...   161   3e-39
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...   161   3e-39
gi|19743806 roundabout 1 isoform b [Homo sapiens]                     154   3e-37
gi|4506569 roundabout 1 isoform a [Homo sapiens]                      154   3e-37
gi|224994173 roundabout 1 isoform d [Homo sapiens]                    150   4e-36
gi|224994171 roundabout 1 isoform c [Homo sapiens]                    150   4e-36
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ...   150   4e-36
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ...   150   4e-36
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   149   1e-35
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   148   2e-35
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   148   2e-35
gi|110349719 titin isoform N2-A [Homo sapiens]                        146   7e-35
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42...   144   5e-34
gi|110431348 deleted in colorectal carcinoma [Homo sapiens]           142   1e-33
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ...   142   1e-33
gi|157311649 neogenin homolog 1 [Homo sapiens]                        140   5e-33
gi|109150416 peroxidasin [Homo sapiens]                               137   6e-32
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]        136   9e-32
gi|142976733 surface glycoprotein, Ig superfamily member [Homo s...   134   5e-31
gi|222352127 sidekick 2 [Homo sapiens]                                132   1e-30
gi|119220552 sidekick 1 [Homo sapiens]                                129   2e-29
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa...   127   6e-29
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo...   126   8e-29
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ...   126   8e-29
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s...   126   8e-29

>gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo
           sapiens]
          Length = 858

 Score = 1727 bits (4472), Expect = 0.0
 Identities = 858/858 (100%), Positives = 858/858 (100%)

Query: 1   MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60
           MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE
Sbjct: 1   MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60

Query: 61  KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120
           KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF
Sbjct: 61  KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120

Query: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180
           KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK
Sbjct: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180

Query: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
           KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF
Sbjct: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240

Query: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
           PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI
Sbjct: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300

Query: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPE 360
           HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPE
Sbjct: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPE 360

Query: 361 KQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG 420
           KQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG
Sbjct: 361 KQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG 420

Query: 421 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 480
           PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS
Sbjct: 421 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 480

Query: 481 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 540
           ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI
Sbjct: 481 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 540

Query: 541 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 600
           LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA
Sbjct: 541 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 600

Query: 601 SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI 660
           SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI
Sbjct: 601 SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI 660

Query: 661 RLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS 720
           RLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS
Sbjct: 661 RLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS 720

Query: 721 TGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFS 780
           TGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFS
Sbjct: 721 TGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFS 780

Query: 781 KDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAE 840
           KDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAE
Sbjct: 781 KDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAE 840

Query: 841 VKTVPNDATQTKENESKA 858
           VKTVPNDATQTKENESKA
Sbjct: 841 VKTVPNDATQTKENESKA 858


>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
           sapiens]
          Length = 848

 Score = 1697 bits (4395), Expect = 0.0
 Identities = 848/858 (98%), Positives = 848/858 (98%), Gaps = 10/858 (1%)

Query: 1   MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60
           MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE
Sbjct: 1   MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60

Query: 61  KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120
           KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF
Sbjct: 61  KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120

Query: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180
           KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK
Sbjct: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180

Query: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
           KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF
Sbjct: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240

Query: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
           PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI
Sbjct: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300

Query: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPE 360
           HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK       
Sbjct: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK------- 353

Query: 361 KQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG 420
              TLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG
Sbjct: 354 ---TLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG 410

Query: 421 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 480
           PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS
Sbjct: 411 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 470

Query: 481 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 540
           ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI
Sbjct: 471 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 530

Query: 541 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 600
           LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA
Sbjct: 531 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590

Query: 601 SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI 660
           SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI
Sbjct: 591 SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI 650

Query: 661 RLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS 720
           RLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS
Sbjct: 651 RLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS 710

Query: 721 TGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFS 780
           TGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFS
Sbjct: 711 TGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFS 770

Query: 781 KDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAE 840
           KDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAE
Sbjct: 771 KDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAE 830

Query: 841 VKTVPNDATQTKENESKA 858
           VKTVPNDATQTKENESKA
Sbjct: 831 VKTVPNDATQTKENESKA 848


>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
           sapiens]
          Length = 761

 Score = 1383 bits (3579), Expect = 0.0
 Identities = 707/772 (91%), Positives = 710/772 (91%), Gaps = 47/772 (6%)

Query: 1   MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60
           MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE
Sbjct: 1   MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60

Query: 61  KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120
           KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF
Sbjct: 61  KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120

Query: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180
           KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK
Sbjct: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180

Query: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
           KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF
Sbjct: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240

Query: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
           PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI
Sbjct: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300

Query: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPE 360
           HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK       
Sbjct: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK------- 353

Query: 361 KQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG 420
              TLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG
Sbjct: 354 ---TLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG 410

Query: 421 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 480
           PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS
Sbjct: 411 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 470

Query: 481 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 540
           ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI
Sbjct: 471 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 530

Query: 541 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 600
           LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA
Sbjct: 531 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590

Query: 601 SEFKTQPV-----------------------------------QGEPSAPKLEGQMGEDG 625
           SEFKTQPV                                   +GEPSAPKLEGQMGEDG
Sbjct: 591 SEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDG 650

Query: 626 NSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVV 685
           NSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVV
Sbjct: 651 NSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVV 710

Query: 686 AENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIVIFVLLLV 737
           AENQQGKSKAAHFVFRTSAQPTAIPA     S   T   V +L     LLL+
Sbjct: 711 AENQQGKSKAAHFVFRTSAQPTAIPATLGGNSASYT--FVSLLFSAVTLLLL 760


>gi|33519481 neural cell adhesion molecule 2 precursor [Homo
           sapiens]
          Length = 837

 Score =  705 bits (1820), Expect = 0.0
 Identities = 383/863 (44%), Positives = 539/863 (62%), Gaps = 39/863 (4%)

Query: 7   LIWTLFFLGTAVS-----LQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEK 61
           L+ + + LG  VS     LQV I  S+ E+SVGESKFF C   G+ +   I W++P GEK
Sbjct: 3   LLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPES--IDWYNPQGEK 60

Query: 62  LTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFK 121
           +   Q+   VV  +   S LTIYNANI+DAGIY+C  T   G   EATV ++I+QKL F+
Sbjct: 61  IISTQR--VVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFR 118

Query: 122 NAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK 181
              +PQEF++GEDA +VC V SS  P + W +   +V    D RF +L+NN LQI  I K
Sbjct: 119 EVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINK 178

Query: 182 TDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241
           +DEG YRCEGR+ ARGEI+F+DI VIVNVPP I   Q   NATA  G+ +T  C A G P
Sbjct: 179 SDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSP 238

Query: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301
           EP +SW ++G+ I   E++EKYI    +++LT++ +  +D   Y+C A NKAGE +    
Sbjct: 239 EPAISWFRNGKLI---EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAF 295

Query: 302 LKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEK 361
           L+VF +P I  ++N+T  E   QVTL C+A G+PIP ITW+ +           +T  E 
Sbjct: 296 LQVFVQPHIIQLKNETTYE-NGQVTLVCDAEGEPIPEITWKRAV--------DGFTFTEG 346

Query: 362 QETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQG 420
            ++LDG + V+     SSL +K ++ +D+G Y C A++ IG   +SMYL+++YAPK +  
Sbjct: 347 DKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISN 406

Query: 421 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 480
               Y+WEGN +NI+C+V + P A+I W RD  +LP+ N +N+K Y+T     LE+ P S
Sbjct: 407 QTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTS 466

Query: 481 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVP 539
           +NDFG YNCTA N IG    E+IL  AD PSSP  +  +E   +TA+V F++P++ GGVP
Sbjct: 467 DNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVP 526

Query: 540 ILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISA 599
           I  Y+ + + V  E+W       +   ++ +V +  L+P TTY +R+AA+NGKG G+ S 
Sbjct: 527 IHHYQVDVKEVASEIWKI----VRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSK 582

Query: 600 ASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSE--WK 657
              F+T PV+ EPS P + GQ    G S K+++ KQDDGG+PI  Y+V+YR+   E  W 
Sbjct: 583 IEIFQTLPVR-EPSPPSIHGQ-PSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWL 640

Query: 658 PEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTS 717
            E ++    DH++L+ L W   YEV + A N+ G S+   + F    +P  I    +  +
Sbjct: 641 -EKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNII--KDTLFN 697

Query: 718 GLSTGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCG-KAGPGAKGKDMEEGK 776
           GL  GA++G+ +   +L+LVV D++C+F+ +CGL MCI   +CG K+G   K K++EEGK
Sbjct: 698 GLGLGAVIGLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGK 757

Query: 777 AAFSKDESKEPIVEVRTEEERTPNH-DGGKHTEPNETTPLTEPEKGPVEAKPECQETETK 835
           AA+ KD SKEPIVE+RTE+ER  NH DG    EPNETTPLTEPEK P+  K E  +    
Sbjct: 758 AAYLKDGSKEPIVEMRTEDERVTNHEDGSPVNEPNETTPLTEPEKLPL--KEEDGKEALN 815

Query: 836 PAPAEVKTVPNDATQTKENESKA 858
           P   E+K V ND  Q+KE++SKA
Sbjct: 816 PETIEIK-VSNDIIQSKEDDSKA 837


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  164 bits (416), Expect = 2e-40
 Identities = 128/438 (29%), Positives = 190/438 (43%), Gaps = 35/438 (7%)

Query: 76   DSSSTLTIYNANIDDAGIYKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGED 134
            ++ S L I +A + D G Y C  T   G +E    VN+ +   +   +  T     EG  
Sbjct: 2154 ENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNL 2213

Query: 135  AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS-NNYLQIRGIKKTDEGTYRCEGRI 193
              ++C+     PP +IWK KG  V+     R  +LS    LQI   +K+D   Y C    
Sbjct: 2214 ISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASN 2273

Query: 194  LARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQ 253
            +A       ++QV +  P    +  +        G+S++L C+ +G P PT++W KDG  
Sbjct: 2274 VAGTAKKEYNLQVYIR-PTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHP 2332

Query: 254  IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI--- 310
            + + +  E     D+   L +K +  +D   Y+C+A N AG  D    L V A P I   
Sbjct: 2333 LIKAKGVE---ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGN 2389

Query: 311  -TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHM 369
                EN + +E +  V+LTCEASG P+PSITW           K  W       +L   +
Sbjct: 2390 HRSPENISVVE-KNSVSLTCEASGIPLPSITW----------FKDGW-----PVSLSNSV 2433

Query: 370  VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA---VYT 426
             + S  R+  L L      DAG+Y C   N  G++ +   L V   P + G      V  
Sbjct: 2434 RILSGGRM--LRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKV 2491

Query: 427  WEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN 486
             E   V +TCEV   P   I+W +DGQ L      +I         +L++T       G 
Sbjct: 2492 KEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHI----ISGGRFLQITNVQVPHTGR 2547

Query: 487  YNCTAVNRIGQESLEFIL 504
            Y C A +  G +S  F L
Sbjct: 2548 YTCLASSPAGHKSRSFSL 2565



 Score =  156 bits (394), Expect = 9e-38
 Identities = 121/483 (25%), Positives = 197/483 (40%), Gaps = 71/483 (14%)

Query: 52   ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEAT-V 110
            I+WF         N  RI           L +    ++DAG Y CVV    G E +   +
Sbjct: 2418 ITWFKDGWPVSLSNSVRIL-----SGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGL 2472

Query: 111  NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
            +V +   ++ +N     + +E +   + C+V  +  P I W HK    + + +   I+  
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITW-HKDGQPLQEDEAHHIISG 2531

Query: 171  NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV--PPTIQ---ARQNIVNATA 225
              +LQI  ++    G Y C    LA      K     +NV   PTI    +  N  + T 
Sbjct: 2532 GRFLQITNVQVPHTGRYTC----LASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTV 2587

Query: 226  NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEY 285
             L    +LVC+A  +P  T++W KDG  +E   +            L I    +++   Y
Sbjct: 2588 ILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIR---ILPGGRTLQILNAQEDNAGRY 2644

Query: 286  ICIAENKAGEQDATIHLKVFAKPKITYVE--------NQTAMELEEQVTLTCEASGDPIP 337
             C+A N+AGE      +KV+  P I   +         +  +++   +TL CEA   P  
Sbjct: 2645 SCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSA 2704

Query: 338  SITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA 397
            S++W    + + S++  +          +GH          +L +K  Q +D G Y C A
Sbjct: 2705 SLSWYKDGQPLKSDDHVNIAA-------NGH----------TLQIKEAQISDTGRYTCVA 2747

Query: 398  SNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE------------------GNQVNITCEVF 439
            SN  G+D     + +Q  P  Q       WE                   N +++ CE  
Sbjct: 2748 SNIAGEDELDFDVNIQVPPSFQ-----KLWEIGNMLDTGRNGEAKDVIINNPISLYCETN 2802

Query: 440  AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 499
            A P  T++W++DG  L SS+    K+   P    L++      D G Y C AVN  G++S
Sbjct: 2803 AAPPPTLTWYKDGHPLTSSD----KVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDS 2858

Query: 500  LEF 502
            L++
Sbjct: 2859 LQY 2861



 Score =  155 bits (392), Expect = 2e-37
 Identities = 116/426 (27%), Positives = 185/426 (43%), Gaps = 35/426 (8%)

Query: 81   LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
            L + +A I D G Y CV     G E +  ++++++                 +   ++C 
Sbjct: 2068 LALTSAQISDTGRYTCVAVNAAG-EKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQ 2126

Query: 141  VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200
              +  PPT+ W   G   +LKK    I  + + L+I   +  D G Y CE   +A G+  
Sbjct: 2127 SDAIPPPTLTWLKDGHP-LLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA-GKTE 2184

Query: 201  FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
             K+  V + VPP I     +   T   G  ++L+C++ G P P + W K G  +  +   
Sbjct: 2185 -KNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMG 2243

Query: 261  EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV---ENQT 317
               I S    QL I   +K+D A Y C+A N AG      +L+V+ +P IT       + 
Sbjct: 2244 RVRILS-GGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEI 2302

Query: 318  AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLD-GHMVVRSHAR 376
             +   + ++L CE  G P P++TW      +         + +  E LD GH+       
Sbjct: 2303 IVTRGKSISLECEVQGIPPPTVTWMKDGHPL--------IKAKGVEILDEGHI------- 2347

Query: 377  VSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG----PVAVYTWEGNQV 432
               L LK+I  +D G Y+C A N  G   +   L V   P + G    P  +   E N V
Sbjct: 2348 ---LQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSV 2404

Query: 433  NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 492
            ++TCE    P  +I+WF+DG   P S  ++++I +      L +   +  D G Y C   
Sbjct: 2405 SLTCEASGIPLPSITWFKDG--WPVSLSNSVRILS--GGRMLRLMQTTMEDAGQYTCVVR 2460

Query: 493  NRIGQE 498
            N  G+E
Sbjct: 2461 NAAGEE 2466



 Score =  151 bits (382), Expect = 2e-36
 Identities = 122/486 (25%), Positives = 193/486 (39%), Gaps = 40/486 (8%)

Query: 26   PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
            P   ++ VG+     C   G      I+W       L   +  +S     +   TL+I  
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPV-ITWSKGGSTMLVDGEHHVS-----NPDGTLSIDQ 1230

Query: 86   ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFRE---GEDAVIVCDV 141
            A   DAGIY CV T   G+ E+E T++V+    +     P    F+E    +     C  
Sbjct: 1231 ATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPA 1290

Query: 142  VSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINF 201
              +  PTI W H GR++  ++    I+     L I  +   D G Y C    +       
Sbjct: 1291 KGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVA--VNEAGTTE 1348

Query: 202  KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE 261
            +   + V+VPP I+ ++ + N +  L Q   L C+ EG P P + W KD  Q+ +    +
Sbjct: 1349 RKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQ 1408

Query: 262  KYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI--TYVENQTAM 319
                 ++   L + +    D   Y C A N AG      ++ V   P I  T   N+ ++
Sbjct: 1409 TV---NNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSV 1465

Query: 320  ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS 379
             L   V L C+  G P P I W         + K  +      E LD         R   
Sbjct: 1466 VLNRDVALECQVKGTPFPDIHW-------FKDGKPLFLGDPNVELLD---------RGQV 1509

Query: 380  LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG---PVAVYTWEGNQVNITC 436
            L LK+ +  D G Y CT SN  G+ ++ + L +   P ++G      +     + + + C
Sbjct: 1510 LHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLEC 1569

Query: 437  EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 496
            E    P   I+W++DGQ + SS+ +   +Y      YL +     +D   Y C   N  G
Sbjct: 1570 ETRGLPMPAITWYKDGQPIMSSSQA---LY-IDKGQYLHIPRAQVSDSATYTCHVANVAG 1625

Query: 497  QESLEF 502
                 F
Sbjct: 1626 TAEKSF 1631



 Score =  151 bits (381), Expect = 3e-36
 Identities = 132/487 (27%), Positives = 205/487 (42%), Gaps = 44/487 (9%)

Query: 26   PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
            P   ++ +  S    C+ AG+     ++W          +  RI           L I +
Sbjct: 1648 PLNKQVVIAHSLTLECKAAGNPSPI-LTWLKDGVPVKANDNIRIEA-----GGKKLEIMS 1701

Query: 86   ANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV--CDVVS 143
            A   D G Y CV T   G E E    V +      +       F    + ++   C V  
Sbjct: 1702 AQEIDRGQYICVATSVAG-EKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTG 1760

Query: 144  SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
            S PPTI+W   G+ +I ++D   I+L+   L I   + ++ G YRC     A    + K+
Sbjct: 1761 SPPPTIMWLKDGQ-LIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGD--HKKE 1817

Query: 204  IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
             +V V+VPPTI++   +        + V L C A G P P+++W KD + +   + + K 
Sbjct: 1818 FEVTVHVPPTIKS-SGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLK- 1875

Query: 264  IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKIT---YVENQTAME 320
                    L I K    D   Y C+A N AGE    I L V   P +     + N+T + 
Sbjct: 1876 -IQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVL- 1933

Query: 321  LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSL 380
            +   V L C+A+G+P+P ITW    R +S     ++                   R   +
Sbjct: 1934 VSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLN-----------------RGQII 1976

Query: 381  TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGP---VAVYTWEGNQVNITCE 437
             ++S Q +DAG Y C A N+ G       L+V  AP + G    VAV     N V + CE
Sbjct: 1977 DIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVV--NNPVRLECE 2034

Query: 438  VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 497
                P+ +++W +DG   P S++SN  +        L +T    +D G Y C AVN  G+
Sbjct: 2035 ARGIPAPSLTWLKDGS--PVSSFSN-GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGE 2091

Query: 498  ESLEFIL 504
            +  +  L
Sbjct: 2092 KQRDIDL 2098



 Score =  151 bits (381), Expect = 3e-36
 Identities = 144/525 (27%), Positives = 217/525 (41%), Gaps = 57/525 (10%)

Query: 78   SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137
            S  L I  A  +DAG Y CV     G+   A   +K+  ++    +P  +E+    D  I
Sbjct: 4040 SGGLQISRAVREDAGTYMCVAQNPAGT---ALGKIKLNVQVPPVISPHLKEYVIAVDKPI 4096

Query: 138  V--CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA 195
               C+     PP I W   GR ++  + +R  VLS+  LQI  ++  D G Y C    +A
Sbjct: 4097 TLSCEADGLPPPDITWHKDGRAIV--ESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVA 4154

Query: 196  RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
                     ++ V+VPP I++ +   + T N      L C A+G P P ++W KD   + 
Sbjct: 4155 GSSST--STKLTVHVPPRIRSTEG--HYTVNENSQAILPCVADGIPTPAINWKKDNVLLA 4210

Query: 256  QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
                  KY  ++   +L ++ V   D   Y C+A N AGE   T+ L V   P  T +  
Sbjct: 4211 NLLG--KYT-AEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG 4267

Query: 316  QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHA 375
              ++   EQ+ L+C+A+G P+P +TW T   NI          P   ++++GH       
Sbjct: 4268 DVSLNKGEQLRLSCKATGIPLPKLTW-TFNNNII---------PAHFDSVNGH------- 4310

Query: 376  RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVN 433
              S L ++ +   D+G Y+CTA N++G      ++ V+  P  +G       E  G    
Sbjct: 4311 --SELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAI 4368

Query: 434  ITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 493
            + CEV   P+ TI W R G  +  S+    ++ N   A Y  V  D+    G+Y C A N
Sbjct: 4369 LNCEVKGDPTPTIQWNRKGVDIEISHRIR-QLGNGSLAIYGTVNEDA----GDYTCVATN 4423

Query: 494  RIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEE 553
              G       L    T  SP I  +EP  +            GG  IL  +A        
Sbjct: 4424 EAGVVERSMSL----TLQSPPIITLEPVETVIN--------AGGKIILNCQATGEPQPTI 4471

Query: 554  VW----HS-KWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG 593
             W    HS  W D         + I   + E T      A N  G
Sbjct: 4472 TWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516



 Score =  149 bits (377), Expect = 8e-36
 Identities = 132/501 (26%), Positives = 217/501 (43%), Gaps = 58/501 (11%)

Query: 26   PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
            P + +I V  +    C+ A       +SW+  +G+ L  +   +++  N     TL I  
Sbjct: 2681 PKEVKIKVNNTLTLECE-AYAIPSASLSWYK-DGQPLK-SDDHVNIAAN---GHTLQIKE 2734

Query: 86   ANIDDAGIYKCV---VTGEDGSESEATVNVKI---FQKLM-FKNAPTPQEFREGEDAVI- 137
            A I D G Y CV   + GED  E +  VN+++   FQKL    N        E +D +I 
Sbjct: 2735 AQISDTGRYTCVASNIAGED--ELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIIN 2792

Query: 138  -----VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGR 192
                  C+  ++ PPT+ W   G   +   D   I+     LQI   K  D G Y C   
Sbjct: 2793 NPISLYCETNAAPPPTLTWYKDGHP-LTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVA- 2850

Query: 193  ILARGEINFK-DIQVIVNVPPTIQARQNIV--NATANLGQSVTLVCDAEGFPEPTMSWTK 249
            +   GE + + D++V+V  PP I+   + +    T  + +S  + C + G P P  SW K
Sbjct: 2851 VNEAGEDSLQYDVRVLV--PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQK 2908

Query: 250  DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309
            DG+ + +   D+ + F  +   L I      D   Y+C+AEN AG      +L V   P 
Sbjct: 2909 DGQPLLE---DDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPS 2965

Query: 310  ITYVENQT-AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGH 368
            +   +++   + +   ++LTCE SG P P +               SW + E+   L+ +
Sbjct: 2966 VIGPKSENLTVVVNNFISLTCEVSGFPPPDL---------------SWLKNEQPIKLNTN 3010

Query: 369  MVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL-----QGPVA 423
             ++    R  +L +   + +D GEY C A N  G+  +   L V   P +     +    
Sbjct: 3011 TLIVPGGR--TLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSV 3068

Query: 424  VYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEND 483
            V   EG  V++ CE  A P   I+W+++G+++  S +  I          L +     +D
Sbjct: 3069 VNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEI----LADGQMLHIKKAEVSD 3124

Query: 484  FGNYNCTAVNRIGQESLEFIL 504
             G Y C A+N  G++   F L
Sbjct: 3125 TGQYVCRAINVAGRDDKNFHL 3145



 Score =  147 bits (371), Expect = 4e-35
 Identities = 126/485 (25%), Positives = 202/485 (41%), Gaps = 59/485 (12%)

Query: 52   ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
            I+WF  +G  L  N+  I ++       TL I NA  D+AG Y CV T E G E      
Sbjct: 2607 ITWFK-DGTPLESNRN-IRIL---PGGRTLQILNAQEDNAGRYSCVATNEAG-EMIKHYE 2660

Query: 112  VKIFQKLMFKN--------APTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKD 163
            VK++   +           +P   + +      + C+  +    ++ W   G+   LK D
Sbjct: 2661 VKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQP--LKSD 2718

Query: 164  VRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVN 222
                + +N + LQI+  + +D G Y C    +A GE    D  V + VPP+ Q    I N
Sbjct: 2719 DHVNIAANGHTLQIKEAQISDTGRYTCVASNIA-GEDEL-DFDVNIQVPPSFQKLWEIGN 2776

Query: 223  A--TANLGQS--------VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQL 272
               T   G++        ++L C+    P PT++W KDG  +   +   K +       L
Sbjct: 2777 MLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSD---KVLILPGGRVL 2833

Query: 273  TIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMEL----EEQVTLT 328
             I +    D   Y C+A N+AGE      ++V   P I    +    E+     +   + 
Sbjct: 2834 QIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIE 2893

Query: 329  CEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYT 388
            C +SG P P               + SW +  +    D H    S+ R+  L + + Q T
Sbjct: 2894 CLSSGSPAP---------------RNSWQKDGQPLLEDDHHKFLSNGRI--LQILNTQIT 2936

Query: 389  DAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA--VYTWEGNQVNITCEVFAYPSATI 446
            D G Y+C A NT G   +   L V   P + GP +  +     N +++TCEV  +P   +
Sbjct: 2937 DIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDL 2996

Query: 447  SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQ 506
            SW ++ Q +  +  + I     P    L++     +D G Y C A+N+ G+   +F L  
Sbjct: 2997 SWLKNEQPIKLNTNTLI----VPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTV 3052

Query: 507  ADTPS 511
               PS
Sbjct: 3053 YVPPS 3057



 Score =  145 bits (366), Expect = 2e-34
 Identities = 132/509 (25%), Positives = 205/509 (40%), Gaps = 58/509 (11%)

Query: 52   ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
            I+W+  NG  +T +   + ++ +      L I  A + D G Y C      G +      
Sbjct: 3091 ITWYK-NGRMITESTH-VEILAD---GQMLHIKKAEVSDTGQYVCRAINVAGRDD----- 3140

Query: 112  VKIFQKLMFKNAPTPQEFREGEDAVIV----------CDVVSSLPPTIIW--KHKGRDVI 159
                 K    N   P      E  VIV          CD     PPTI W   HK  +  
Sbjct: 3141 -----KNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENS 3195

Query: 160  LKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQN 219
               +VR I+   + LQI   + +D G Y C    +  G+   K   + + VPP++   + 
Sbjct: 3196 DSLEVR-ILSGGSKLQIARSQHSDSGNYTCIASNM-EGKAQ-KYYFLSIQVPPSVAGAEI 3252

Query: 220  IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDK 279
              + +  LG++V LVC+A G P P + W KDG+ I   E  E+   S + S L I     
Sbjct: 3253 PSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE-TERIRVSANGSTLNIYGALT 3311

Query: 280  NDEAEYICIAENKAGEQDATIHLKVFAKPKI--TYVENQTAMEL-EEQVTLTCEASGDPI 336
            +D  +Y C+A N AGE+D   +L V+  P I     E +  M L +  + + C A+G P 
Sbjct: 3312 SDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371

Query: 337  PSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICT 396
            P I W  +   +                L  H  +R  A    + +   Q +D   Y C 
Sbjct: 3372 PQINWLKNGLPL---------------PLSSH--IRLLAAGQVIRIVRAQVSDVAVYTCV 3414

Query: 397  ASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 453
            ASN  G D++   L+V   P +    G   +   +G+  ++ C     P+ +++W RDGQ
Sbjct: 3415 ASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQ 3474

Query: 454  LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSP 513
             L    +  +  +       L++      D G Y C A N  G+ S  FIL   + P   
Sbjct: 3475 PLGLDAHLTVSTH----GMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHIN 3530

Query: 514  SIDQVEPYSSTAQVQFDEPEATGGVPILK 542
              ++ E  S       +      G+P  K
Sbjct: 3531 GSEEHEEISVIVNNPLELTCIASGIPAPK 3559



 Score =  143 bits (361), Expect = 6e-34
 Identities = 125/493 (25%), Positives = 199/493 (40%), Gaps = 49/493 (9%)

Query: 26   PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
            P++  ++ G+S    C+V G      ++W       +      I      D    L + N
Sbjct: 2299 PTEIIVTRGKSISLECEVQG-IPPPTVTWMKDGHPLIKAKGVEIL-----DEGHILQLKN 2352

Query: 86   ANIDDAGIYKCVVTGEDG-SESEATVNVKIFQKLMFKN-APTPQEFREGEDAVIVCDVVS 143
             ++ D G Y CV     G ++ +  ++V     ++  + +P      E     + C+   
Sbjct: 2353 IHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASG 2412

Query: 144  SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
               P+I W   G  V L   VR I+     L++      D G Y C  R  A  E     
Sbjct: 2413 IPLPSITWFKDGWPVSLSNSVR-ILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFG 2471

Query: 204  IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
            + V+V  PP I     + +      QSVTL C+  G P P ++W KDG+ +  +ED+  +
Sbjct: 2472 LSVLV--PPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPL--QEDEAHH 2527

Query: 264  IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--- 320
            I S     L I  V       Y C+A + AG +  +  L VF  P I  V +    E   
Sbjct: 2528 IIS-GGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVT 2586

Query: 321  --LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVS 378
              L    +L CEA   P  +ITW      + S                    +R      
Sbjct: 2587 VILNSPTSLVCEAYSYPPATITWFKDGTPLESNRN-----------------IRILPGGR 2629

Query: 379  SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ---------GPVAVYTWEG 429
            +L + + Q  +AG Y C A+N  G+  +   ++V   P +           P  V     
Sbjct: 2630 TLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVN 2689

Query: 430  NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 489
            N + + CE +A PSA++SW++DGQ L S ++ NI      +   L++     +D G Y C
Sbjct: 2690 NTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNI----AANGHTLQIKEAQISDTGRYTC 2745

Query: 490  TAVNRIGQESLEF 502
             A N  G++ L+F
Sbjct: 2746 VASNIAGEDELDF 2758



 Score =  142 bits (359), Expect = 1e-33
 Identities = 106/424 (25%), Positives = 177/424 (41%), Gaps = 27/424 (6%)

Query: 75  DDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGED 134
           + +S  L I    + D G Y+C+     G+   A     + +       P       GE 
Sbjct: 478 ESASVNLDIAKVTLSDEGFYECIAVSSAGT-GRAQTFFDVSEPPPVIQVPNNVTVTPGER 536

Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRIL 194
           AV+ C ++S++   + W+   RDV L +  R   L+N  L+++ +K  D G Y C   + 
Sbjct: 537 AVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHC--MVS 594

Query: 195 ARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254
           + G  +   + + V  PP +       N +   G  V+++C A G+P+P ++WT +   I
Sbjct: 595 SEGGSSAASVFLTVQEPPKVTVMPK--NQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFI 652

Query: 255 EQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE 314
                  +Y  + D + L IK     D   Y C+A N AG       L+    PK+  V+
Sbjct: 653 ---VGSHRYRMTSDGT-LFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQ 708

Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSH 374
           ++  + L +   + C+ SG P P + W      +         RP     +D        
Sbjct: 709 SELLVALGDITVMECKTSGIPPPQVKWFKGDLEL---------RPSTFLIID-------- 751

Query: 375 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVN 433
             +  L ++  Q  DAG+Y C A N  G+ +  + L+V   P  +Q P  V    G+ V 
Sbjct: 752 PLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVT 811

Query: 434 ITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 493
           + C V  YP  TI W R   +   S   ++   +      L +     +D G Y C A N
Sbjct: 812 LPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAEN 871

Query: 494 RIGQ 497
           + G+
Sbjct: 872 QFGK 875



 Score =  140 bits (354), Expect = 4e-33
 Identities = 118/483 (24%), Positives = 202/483 (41%), Gaps = 51/483 (10%)

Query: 41   CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
            C+ AG+     I+W+  N  +L      ++ +   +    + I +A I DAGIYKCV   
Sbjct: 1942 CKAAGNPVPV-ITWYKDN--RLLSGSTSMTFL---NRGQIIDIESAQISDAGIYKCVAIN 1995

Query: 101  EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI------VCDVVSSLPPTIIWKHK 154
              G+        ++F  L    AP+          V+       C+      P++ W   
Sbjct: 1996 SAGA-------TELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKD 2048

Query: 155  GRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTI 214
            G  V    +   ++     L +   + +D G Y C   + A GE   +DI + V VPP I
Sbjct: 2049 GSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVA-VNAAGEKQ-RDIDLRVYVPPNI 2106

Query: 215  QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTI 274
               +   N +  + Q+V L+C ++  P PT++W KDG  + ++        S++ S L I
Sbjct: 2107 MGEEQ--NVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPG---LSISENRSVLKI 2161

Query: 275  KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQ--VTLTCEAS 332
            +     D   Y C A N AG+ +   ++ ++  P I   +  T + + E   ++L CE+S
Sbjct: 2162 EDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESS 2221

Query: 333  GDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGE 392
            G P P++ W+     + ++               G + + S  R   L +   + +DA  
Sbjct: 2222 GIPPPNLIWKKKGSPVLTDSM-------------GRVRILSGGR--QLQISIAEKSDAAL 2266

Query: 393  YICTASNTIGQDSQSMYLEVQYAPKLQG----PVAVYTWEGNQVNITCEVFAYPSATISW 448
            Y C ASN  G   +   L+V   P +      P  +    G  +++ CEV   P  T++W
Sbjct: 2267 YSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTW 2326

Query: 449  FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD 508
             +DG   P      ++I +      L++     +D G Y C AVN  G    ++ L    
Sbjct: 2327 MKDGH--PLIKAKGVEILD--EGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHA 2382

Query: 509  TPS 511
             PS
Sbjct: 2383 PPS 2385



 Score =  138 bits (347), Expect = 2e-32
 Identities = 122/464 (26%), Positives = 183/464 (39%), Gaps = 42/464 (9%)

Query: 81   LTIYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGEDAVIVC 139
            L I  A ++D G Y C+ +   G +  E  V V +   +   + P            + C
Sbjct: 3584 LRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLEC 3643

Query: 140  DVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 199
               +  PP I W   G  +     VR I+    YLQI      D   Y C    +A G+ 
Sbjct: 3644 KSDAVPPPVITWLRNGERLQATPRVR-ILSGGRYLQINNADLGDTANYTCVASNIA-GKT 3701

Query: 200  NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
              ++  + VNVPP I+      +    L +S  L C AEG P P ++W KDG  +     
Sbjct: 3702 T-REFILTVNVPPNIKGGPQ--SLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHA 3758

Query: 260  DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
                +   ++  L I+     D   Y+C+A N AG     I L+V   P I        +
Sbjct: 3759 RYSIL---ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTV 3815

Query: 320  ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS 379
             +  Q TL CEA+G P PSI WR +   ++ ++             + + ++ S     S
Sbjct: 3816 IVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQ-----------NSYRLLSS----GS 3860

Query: 380  LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL-QGPVAVYTWEGNQVNITCEV 438
            L + S    D   Y CT +N  G D +++ L VQ  P +   P      +     ITC  
Sbjct: 3861 LVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTA 3920

Query: 439  FAYPSATISWFRDG-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 497
               P  +I W ++G +LLP  +      Y   S+  +E+     N  G Y C A N  G 
Sbjct: 3921 SGVPFPSIHWTKNGIRLLPRGDG-----YRILSSGAIEILATQLNHAGRYTCVARNAAGS 3975

Query: 498  ESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEP-----EATG 536
                  L   + P       ++P  S   V  + P     EATG
Sbjct: 3976 AHRHVTLHVHEPP------VIQPQPSELHVILNNPILLPCEATG 4013



 Score =  136 bits (342), Expect = 9e-32
 Identities = 114/422 (27%), Positives = 174/422 (41%), Gaps = 34/422 (8%)

Query: 81   LTIYNANIDDAGIYKCVVT---GEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137
            L I  A + + G+Y+C+     G+   E E TV+V        K++   +        V 
Sbjct: 1790 LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPP----TIKSSGLSERVVVKYKPVA 1845

Query: 138  VCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
            +  + + +P P+I W    + V   +    I  S   LQI      D G Y C     A 
Sbjct: 1846 LQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAA- 1904

Query: 197  GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
            GE   + IQ+ V+ PP+++    ++N T  +   V L C A G P P ++W KD   +  
Sbjct: 1905 GETQ-QHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLS- 1962

Query: 257  EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
                    F +    + I+    +D   Y C+A N AG  +    L+V   P I+   N 
Sbjct: 1963 --GSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNM 2020

Query: 317  TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHAR 376
             A+ +   V L CEA G P PS+TW      +SS                  + V S  R
Sbjct: 2021 VAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSS--------------FSNGLQVLSGGR 2066

Query: 377  VSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA-VYTWEGNQVNIT 435
            + +LT  S Q +D G Y C A N  G+  + + L V   P + G    V       V + 
Sbjct: 2067 ILALT--SAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELL 2124

Query: 436  CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 495
            C+  A P  T++W +DG  L      +I    + + S L++      D G Y C A N  
Sbjct: 2125 CQSDAIPPPTLTWLKDGHPLLKKPGLSI----SENRSVLKIEDAQVQDTGRYTCEATNVA 2180

Query: 496  GQ 497
            G+
Sbjct: 2181 GK 2182



 Score =  135 bits (340), Expect = 2e-31
 Identities = 130/488 (26%), Positives = 198/488 (40%), Gaps = 51/488 (10%)

Query: 24   IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTI 83
            +V S+  +++G+     C+ +G      + WF  + E L P+   I     D     L I
Sbjct: 706  VVQSELLVALGDITVMECKTSG-IPPPQVKWFKGDLE-LRPSTFLII----DPLLGLLKI 759

Query: 84   YNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVS 143
                  DAG Y CV   E G  +   + + +    +F   P       G +  + C V  
Sbjct: 760  QETQDLDAGDYTCVAINEAG-RATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQG 818

Query: 144  SLPPTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGRILARGEIN 200
               PTI W+      I  +      +S      L I  +  +D+GTY CE    A  +  
Sbjct: 819  YPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICE----AENQFG 874

Query: 201  FKDIQVIVNVPPTIQARQNIVNATANL--GQSVTLVCDA-EGFPEPTMSWTKDGEQIEQE 257
                +  V V   +     I  + AN+  GQ +TL C    G P P   W K+   + Q 
Sbjct: 875  KIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQN 934

Query: 258  EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
                 YI       L I++V   D  EY C+A N AG  + T  + V   P I + +   
Sbjct: 935  P----YITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQIL 990

Query: 318  AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARV 377
            +      VTL C+ASG+P PS+ W                  +K E +       S    
Sbjct: 991  STIEGIPVTLPCKASGNPKPSVIW-----------------SKKGELISTSSAKFSAGAD 1033

Query: 378  SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG---------PVAVYTWE 428
             SL + S    ++GEY+CTA+NT G   + + L V   P++ G         PV +    
Sbjct: 1034 GSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLA 1093

Query: 429  GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
            G +V + CEV + P   I+W ++ QL+  S +S    +  PS S +++T    +D G Y 
Sbjct: 1094 GEEVTLPCEVKSLPPPIITWAKETQLI--SPFSPRHTF-LPSGS-MKITETRTSDSGMYL 1149

Query: 489  CTAVNRIG 496
            C A N  G
Sbjct: 1150 CVATNIAG 1157



 Score =  135 bits (340), Expect = 2e-31
 Identities = 114/443 (25%), Positives = 184/443 (41%), Gaps = 36/443 (8%)

Query: 78   SSTLTIYNANIDDAGIYKCVVTGEDGSESEAT-VNVKIFQKLMFKNAPTPQEFREGEDAV 136
            S ++ I      D+G+Y CV T   G+ ++A  +NV +  K+  +  P   + + G+   
Sbjct: 1132 SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI--QRGPKHLKVQVGQRVD 1189

Query: 137  IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
            I C+   +  P I W  KG   +L      +   +  L I     +D G Y C    +A 
Sbjct: 1190 IPCNAQGTPLPVITWS-KGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAG 1248

Query: 197  GEINFKDIQVIVNVPPTIQARQNIVNATAN---LGQSVTLVCDAEGFPEPTMSWTKDGEQ 253
             +    +I + V  PPT++  +   N T       Q +   C A+G P+PT+ W  +G +
Sbjct: 1249 TDET--EITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRE 1306

Query: 254  IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV 313
            +   E     +  +D + L I  V   D  EYIC+A N+AG  +   +LKV   P I   
Sbjct: 1307 LTGREPGISIL--EDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDK 1364

Query: 314  ENQTAME--LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVV 371
            E  T +   L +   L CE  G P P I W         ++    T     +T++   ++
Sbjct: 1365 EQVTNVSVLLNQLTNLFCEVEGTPSPIIMWY--------KDNVQVTESSTIQTVNNGKIL 1416

Query: 372  RSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG---PVAVYTWE 428
            +                DAG Y C A N  G   +   ++V   P + G   P  V    
Sbjct: 1417 KLFRATPE---------DAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVL 1467

Query: 429  GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
               V + C+V   P   I WF+DG+ L   +  N+++ +     +L+      ND G Y 
Sbjct: 1468 NRDVALECQVKGTPFPDIHWFKDGKPLFLGD-PNVELLDRGQVLHLKNA--RRNDKGRYQ 1524

Query: 489  CTAVNRIGQESLEFILVQADTPS 511
            CT  N  G+++ +  L     PS
Sbjct: 1525 CTVSNAAGKQAKDIKLTIYIPPS 1547



 Score =  135 bits (339), Expect = 2e-31
 Identities = 119/467 (25%), Positives = 197/467 (42%), Gaps = 39/467 (8%)

Query: 52   ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
            I+W+  +G+ +  + Q + +    D    L I  A + D+  Y C V    G+ +E + +
Sbjct: 1579 ITWYK-DGQPIMSSSQALYI----DKGQYLHIPRAQVSDSATYTCHVANVAGT-AEKSFH 1632

Query: 112  VKIFQKLMFK-NAPTP--QEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIV 168
            V ++   M + N  TP  ++        + C    +  P + W   G  V    ++R I 
Sbjct: 1633 VDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIR-IE 1691

Query: 169  LSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLG 228
                 L+I   ++ D G Y C    +A GE   K  +V V VPP I+           + 
Sbjct: 1692 AGGKKLEIMSAQEIDRGQYICVATSVA-GEKEIK-YEVDVLVPPAIEGGDETSYFIVMVN 1749

Query: 229  QSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICI 288
              + L C   G P PT+ W KDG+ I+ E D  K +   +  +L I +   ++   Y C+
Sbjct: 1750 NLLELDCHVTGSPPPTIMWLKDGQLID-ERDGFKILL--NGRKLVIAQAQVSNTGLYRCM 1806

Query: 289  AENKAGEQDATIHLKVFAKPKI-TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347
            A N AG+      + V   P I +   ++  +   + V L C A+G P PSITW    + 
Sbjct: 1807 AANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQP 1866

Query: 348  ISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS 407
            ++              T  G++ ++S  RV  L +      DAG Y C A+N  G+  Q 
Sbjct: 1867 VN--------------TAQGNLKIQSSGRV--LQIAKTLLEDAGRYTCVATNAAGETQQH 1910

Query: 408  MYLEVQYAPKLQGPVAVY---TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIK 464
            + L V   P L+    +        N V + C+    P   I+W++D +LL  S  +++ 
Sbjct: 1911 IQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGS--TSMT 1968

Query: 465  IYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 511
              N      +++     +D G Y C A+N  G   L + L     PS
Sbjct: 1969 FLN--RGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013



 Score =  131 bits (330), Expect = 2e-30
 Identities = 117/490 (23%), Positives = 195/490 (39%), Gaps = 38/490 (7%)

Query: 12   FFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISV 71
            F L   V   +   P    I + +S    C +A       I+W   +G  L  N  R S+
Sbjct: 3705 FILTVNVPPNIKGGPQSLVILLNKSTVLEC-IAEGVPTPRITW-RKDGAVLAGNHARYSI 3762

Query: 72   VWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE 131
            + N      L I +A++ D G Y C+ T   G++    +++++         PT      
Sbjct: 3763 LEN----GFLHIQSAHVTDTGRYLCMATNAAGTDRRR-IDLQVHVPPSIAPGPTNMTVIV 3817

Query: 132  GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVR-FIVLSNNYLQIRGIKKTDEGTYRCE 190
                 + C+      P+I W+  G  + + ++   + +LS+  L I      D  TY C 
Sbjct: 3818 NVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECT 3877

Query: 191  GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
              +      + + + + V VPP+I         T +    +T  C A G P P++ WTK+
Sbjct: 3878 --VTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVIT--CTASGVPFPSIHWTKN 3933

Query: 251  GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310
            G ++    D  + +    S  + I     N    Y C+A N AG     + L V   P I
Sbjct: 3934 GIRLLPRGDGYRIL---SSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVI 3990

Query: 311  TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMV 370
                ++  + L   + L CEA+G P P ITW+    N+++  +              H V
Sbjct: 3991 QPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGR-------------NHAV 4037

Query: 371  VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN 430
            + S      L +      DAG Y+C A N  G     + L VQ  P +   +  Y    +
Sbjct: 4038 LPS----GGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVD 4093

Query: 431  Q-VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 489
            + + ++CE    P   I+W +DG+ +  S    +      S+  L++      D G+Y C
Sbjct: 4094 KPITLSCEADGLPPPDITWHKDGRAIVESIRQRVL-----SSGSLQIAFVQPGDAGHYTC 4148

Query: 490  TAVNRIGQES 499
             A N  G  S
Sbjct: 4149 MAANVAGSSS 4158



 Score =  124 bits (312), Expect = 3e-28
 Identities = 120/523 (22%), Positives = 200/523 (38%), Gaps = 39/523 (7%)

Query: 77   SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGED 134
            +   + I  A + D  +Y CV +   G +++   N+++F      N+   +E    +G  
Sbjct: 3394 AGQVIRIVRAQVSDVAVYTCVASNRAGVDNKH-YNLQVFAPPNMDNSMGTEEITVLKGSS 3452

Query: 135  AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRI 193
              + C    +  P++ W   G+ + L  D    V ++   LQ+   +  D G Y C    
Sbjct: 3453 TSMACITDGTPAPSMAWLRDGQPLGL--DAHLTVSTHGMVLQLLKAETEDSGKYTCIASN 3510

Query: 194  LARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQ 253
             A GE++ K   + V  PP I   +     +  +   + L C A G P P M+W KDG  
Sbjct: 3511 EA-GEVS-KHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRP 3568

Query: 254  IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV 313
            + Q +  +          L I      D   Y C+A + AG+ D    ++V   P I   
Sbjct: 3569 LPQTDQVQTL---GGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGT 3625

Query: 314  ENQTAMEL--EEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVV 371
            +    + +    QVTL C++   P P ITW  +   + +  +                 V
Sbjct: 3626 DEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPR-----------------V 3668

Query: 372  RSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGN 430
            R  +    L + +    D   Y C ASN  G+ ++   L V   P ++ GP ++      
Sbjct: 3669 RILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNK 3728

Query: 431  QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 490
               + C     P+  I+W +DG +L + N++    Y+     +L +      D G Y C 
Sbjct: 3729 STVLECIAEGVPTPRITWRKDGAVL-AGNHAR---YSILENGFLHIQSAHVTDTGRYLCM 3784

Query: 491  AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 550
            A N  G +    I +Q   P  PSI    P + T  V      A     I K    WR  
Sbjct: 3785 ATNAAGTDRRR-IDLQVHVP--PSI-APGPTNMTVIVNVQTTLACEATGIPKPSINWRKN 3840

Query: 551  GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG 593
            G  +   +  ++      G + I+    + T        NG G
Sbjct: 3841 GHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAG 3883



 Score =  122 bits (307), Expect = 1e-27
 Identities = 113/483 (23%), Positives = 186/483 (38%), Gaps = 42/483 (8%)

Query: 77   SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAV 136
            S  +L I    + D G Y CV +   G+ ++ T +V +      ++        EG    
Sbjct: 941  SDGSLHIERVQLQDGGEYTCVASNVAGTNNKTT-SVVVHVLPTIQHGQQILSTIEGIPVT 999

Query: 137  IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
            + C    +  P++IW  KG ++I     +F   ++  L +      + G Y C     A 
Sbjct: 1000 LPCKASGNPKPSVIWSKKG-ELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTA- 1057

Query: 197  GEINFKDIQVIVNVPPTIQARQN------IVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
            G    K +Q+ V V P +   Q        V  +   G+ VTL C+ +  P P ++W K+
Sbjct: 1058 GYAKRK-VQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKE 1116

Query: 251  GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310
             + I        ++    S  + I +   +D   Y+C+A N AG     + L V   PKI
Sbjct: 1117 TQLISPFSPRHTFL---PSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI 1173

Query: 311  TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMV 370
                    +++ ++V + C A G P+P ITW      +  + +   + P+          
Sbjct: 1174 QRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---------- 1223

Query: 371  VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW--- 427
                    +L++     +DAG Y C A+N  G D   + L VQ  P ++     Y     
Sbjct: 1224 -------GTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQ 1276

Query: 428  ---EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 484
                  ++   C     P  TI W  +G+ L +     I I      + L +   +  D 
Sbjct: 1277 ERVANQRIEFPCPAKGTPKPTIKWLHNGREL-TGREPGISILE--DGTLLVIASVTPYDN 1333

Query: 485  GNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYS---STAQVQFDEPEATGGVPIL 541
            G Y C AVN  G    ++ L     P     +QV   S   +     F E E T    I+
Sbjct: 1334 GEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIM 1393

Query: 542  KYK 544
             YK
Sbjct: 1394 WYK 1396



 Score =  121 bits (303), Expect = 3e-27
 Identities = 115/476 (24%), Positives = 187/476 (39%), Gaps = 37/476 (7%)

Query: 25  VPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIY 84
           VP+   ++ GE     C +   A D +++W   + +       RI  + N     +L + 
Sbjct: 525 VPNNVTVTPGERAVLTCLIIS-AVDYNLTWQRNDRDVRLAEPARIRTLAN----LSLELK 579

Query: 85  NANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144
           +   +DAG Y C+V+ E GS S A+V + + +       P  Q F  G +  I+C     
Sbjct: 580 SVKFNDAGEYHCMVSSEGGS-SAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGY 638

Query: 145 LPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204
             P I W     D+ +    R+ + S+  L I+     D G Y C     A  +     +
Sbjct: 639 PKPKIAWTVN--DMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTL 696

Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264
           + I   P  +  +  ++ A   LG    + C   G P P + W K   ++         I
Sbjct: 697 RYI-EAPKLMVVQSELLVA---LGDITVMECKTSGIPPPQVKWFKGDLELRPSTF---LI 749

Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQ 324
                  L I++    D  +Y C+A N+AG     I L V + P         +ME+   
Sbjct: 750 IDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSN 809

Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKS 384
           VTL C   G P P+I WR        +    ++RP    ++       S  R  +L + +
Sbjct: 810 VTLPCYVQGYPEPTIKWR------RLDNMPIFSRPFSVSSI-------SQLRTGALFILN 856

Query: 385 IQYTDAGEYICTASNTIG--QDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFA- 440
           +  +D G YIC A N  G  Q   ++ +    AP +   P      EG Q+ + C + A 
Sbjct: 857 LWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAG 916

Query: 441 YPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 496
            P     W ++  +L  + Y  ++     S   L +      D G Y C A N  G
Sbjct: 917 NPIPERRWIKNSAMLLQNPYITVR-----SDGSLHIERVQLQDGGEYTCVASNVAG 967



 Score =  117 bits (293), Expect = 5e-26
 Identities = 116/452 (25%), Positives = 178/452 (39%), Gaps = 50/452 (11%)

Query: 51   DISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
            DI+W       +   +QR+       SS +L I      DAG Y C+     GS S +T 
Sbjct: 4109 DITWHKDGRAIVESIRQRVL------SSGSLQIAFVQPGDAGHYTCMAANVAGSSSTST- 4161

Query: 111  NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTIIWKHKGRDVILKKDV--RFI 167
             + +      ++        E   A++ C V   +P P I WK   +D +L  ++  ++ 
Sbjct: 4162 KLTVHVPPRIRSTEGHYTVNENSQAILPC-VADGIPTPAINWK---KDNVLLANLLGKYT 4217

Query: 168  VLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANL 227
                  L +  +   D G Y C     A GE +   + + V+V PT        + + N 
Sbjct: 4218 AEPYGELILENVVLEDSGFYTCVAN-NAAGE-DTHTVSLTVHVLPTFTELPG--DVSLNK 4273

Query: 228  GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
            G+ + L C A G P P ++WT +   I    D       +  S+L I++V K D   Y+C
Sbjct: 4274 GEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDS-----VNGHSELVIERVSKEDSGTYVC 4328

Query: 288  IAENKAGEQDATIHLKVFAKP--KITYVENQTAMELEEQVTLTCEASGDPIPSITWRTST 345
             AEN  G   A   + V   P  K  Y  N     L     L CE  GDP P+I W    
Sbjct: 4329 TAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIE-PLGGNAILNCEVKGDPTPTIQWNRKG 4387

Query: 346  RNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDS 405
             +I    +                 +R      SL +      DAG+Y C A+N  G   
Sbjct: 4388 VDIEISHR-----------------IRQLGN-GSLAIYGTVNEDAGDYTCVATNEAGVVE 4429

Query: 406  QSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIK 464
            +SM L +Q  P +   PV      G ++ + C+    P  TI+W R G  +   +  N+ 
Sbjct: 4430 RSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVL 4489

Query: 465  IYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 496
              N+     L +    + D   + C A N +G
Sbjct: 4490 SNNS-----LYIADAQKEDTSEFECVARNLMG 4516



 Score =  107 bits (267), Expect = 5e-23
 Identities = 98/378 (25%), Positives = 156/378 (41%), Gaps = 37/378 (9%)

Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
           I C V S LP T+ +   G  V L  D      ++  L I  +  +DEG Y C   + + 
Sbjct: 449 IPCSVDSLLPFTLSFVRNG--VTLGVDQYLKESASVNLDIAKVTLSDEGFYECIA-VSSA 505

Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
           G    +    +   PP IQ   N+   T   G+   L C      +  ++W ++   +  
Sbjct: 506 GTGRAQTFFDVSEPPPVIQVPNNV---TVTPGERAVLTCLIISAVDYNLTWQRNDRDVRL 562

Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
            E       ++ S  L +K V  ND  EY C+  ++ G   A++ L V   PK+T +   
Sbjct: 563 AEPARIRTLANLS--LELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKN 620

Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHAR 376
            +     +V++ C A+G P P I W  +   I    +        + T DG         
Sbjct: 621 QSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHR-------YRMTSDG--------- 664

Query: 377 VSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGNQVN 433
             +L +K+    DAG Y C ASN+ G D Q+  L    APKL   Q  + V    G+   
Sbjct: 665 --TLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVAL--GDITV 720

Query: 434 ITCEVFAYPSATISWFR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 492
           + C+    P   + WF+ D +L PS+      +   P    L++    + D G+Y C A+
Sbjct: 721 MECKTSGIPPPQVKWFKGDLELRPST-----FLIIDPLLGLLKIQETQDLDAGDYTCVAI 775

Query: 493 NRIGQESLEFILVQADTP 510
           N  G+ + +  L     P
Sbjct: 776 NEAGRATGKITLDVGSPP 793


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score =  161 bits (407), Expect = 3e-39
 Identities = 186/739 (25%), Positives = 287/739 (38%), Gaps = 89/739 (12%)

Query: 26  PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
           PS   +S GE     C+  G      I W+  +GE++      P   R+ +         
Sbjct: 53  PSDVIVSKGEPTTLNCKAEG-RPTPTIEWYK-DGERVETDKDDPRSHRMLLPSGSLFFLR 110

Query: 81  LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKI-FQKLMFKNAPTPQEFREGEDAVIVC 139
           +     +  D G Y CV     G       ++++   +  F+  PT      GE A++ C
Sbjct: 111 IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 170

Query: 140 DVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE 198
                 P PTI WK K +  I  K+ R I +    L I   +K+D G Y C G  +  GE
Sbjct: 171 QPPRGHPEPTIYWK-KDKVRIDDKEER-ISIRGGKLMISNTRKSDAGMYTCVGTNMV-GE 227

Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
            +    ++ V   PT   R   +N      ++V   C  +G P+PT+ W KD   + +  
Sbjct: 228 RDSDPAELTVFERPTFLRRP--INQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR 285

Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
            D K     D   L IKK    DE  Y+CIAEN+ G+ +A+  L V A P+         
Sbjct: 286 YDIK-----DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 340

Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVS 378
           +     VT  CE  G+P P++ W+        E   +   P + +  +    V   +   
Sbjct: 341 VAQGRTVTFPCETKGNPQPAVFWQ-------KEGSQNLLFPNQPQQPNSRCSV---SPTG 390

Query: 379 SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-------LQGPVAVYTWEGNQ 431
            LT+ +IQ +DAG YIC A    G       LEV            LQGP          
Sbjct: 391 DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGT 450

Query: 432 VNITCEVFAYPSATISWFRDGQLLPSSN-YSNIKIYNTPSASYLEVTPDSENDFGNYNCT 490
             + C+    P   ISW ++G   P  +  + I+   T     L +     +D G Y C 
Sbjct: 451 ALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI-----SDTGTYTCV 505

Query: 491 AVNRIGQESLEFIL-------------VQADTPSSPSIDQVEPYSSTAQVQFDEPEATGG 537
           A +  G+ S   +L               +D P  PS  QV   +  +     +P   G 
Sbjct: 506 ATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGT 565

Query: 538 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 597
           +P   Y  E  A  + V +S W          + T+ GL+P T Y   + A+N +GL + 
Sbjct: 566 LPASAYIIE--AFSQSVSNS-WQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDP 622

Query: 598 SAASEFKTQPVQGEPSAPKLEG----QMGEDGNSIKVNLIKQ--------------DDGG 639
           S  S+    PV+ +  +P  +G    Q+ ++   + V L                 D   
Sbjct: 623 SPMSD----PVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQP 678

Query: 640 SPIRHYLVRYRALS-----SEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQG 691
             I+ Y V YR  S     S W+  + ++P+    V++ +L     YE+ V       QG
Sbjct: 679 QFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLV-NLKKGVTYEIKVRPYFNEFQG 737

Query: 692 KSKAAHFVFRTSAQPTAIP 710
               +  V  T   P+A P
Sbjct: 738 MDSESKTVRTTEEAPSAPP 756



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 59/241 (24%), Positives = 92/241 (38%), Gaps = 29/241 (12%)

Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDG 367
           P+I    +   +   E  TL C+A G P P+I W      + +++     R  +     G
Sbjct: 47  PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDD--PRSHRMLLPSG 104

Query: 368 HMVVRS--HARVSSLTLKSIQYTDAGEYICTASNTIGQD-SQSMYLEVQYAPK--LQGPV 422
            +      H R S          D G Y+C A N +G+  S++  LEV        Q P 
Sbjct: 105 SLFFLRIVHGRRSK--------PDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 156

Query: 423 AVYTWEGNQVNITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSE 481
            V    G    + C+    +P  TI W +D ++        I I        L ++   +
Sbjct: 157 DVVVAAGEPAILECQPPRGHPEPTIYWKKD-KVRIDDKEERISI----RGGKLMISNTRK 211

Query: 482 NDFGNYNCTAVNRIGQ---ESLEFILVQADTPSSPSIDQV----EPYSSTAQVQFDEPEA 534
           +D G Y C   N +G+   +  E  + +  T     I+QV    E      QVQ D P+ 
Sbjct: 212 SDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGD-PQP 270

Query: 535 T 535
           T
Sbjct: 271 T 271


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2b [Homo sapiens]
          Length = 1378

 Score =  161 bits (407), Expect = 3e-39
 Identities = 186/739 (25%), Positives = 287/739 (38%), Gaps = 89/739 (12%)

Query: 26  PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
           PS   +S GE     C+  G      I W+  +GE++      P   R+ +         
Sbjct: 37  PSDVIVSKGEPTTLNCKAEG-RPTPTIEWYK-DGERVETDKDDPRSHRMLLPSGSLFFLR 94

Query: 81  LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKI-FQKLMFKNAPTPQEFREGEDAVIVC 139
           +     +  D G Y CV     G       ++++   +  F+  PT      GE A++ C
Sbjct: 95  IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 154

Query: 140 DVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE 198
                 P PTI WK K +  I  K+ R I +    L I   +K+D G Y C G  +  GE
Sbjct: 155 QPPRGHPEPTIYWK-KDKVRIDDKEER-ISIRGGKLMISNTRKSDAGMYTCVGTNMV-GE 211

Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
            +    ++ V   PT   R   +N      ++V   C  +G P+PT+ W KD   + +  
Sbjct: 212 RDSDPAELTVFERPTFLRRP--INQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR 269

Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
            D K     D   L IKK    DE  Y+CIAEN+ G+ +A+  L V A P+         
Sbjct: 270 YDIK-----DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 324

Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVS 378
           +     VT  CE  G+P P++ W+        E   +   P + +  +    V   +   
Sbjct: 325 VAQGRTVTFPCETKGNPQPAVFWQ-------KEGSQNLLFPNQPQQPNSRCSV---SPTG 374

Query: 379 SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-------LQGPVAVYTWEGNQ 431
            LT+ +IQ +DAG YIC A    G       LEV            LQGP          
Sbjct: 375 DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGT 434

Query: 432 VNITCEVFAYPSATISWFRDGQLLPSSN-YSNIKIYNTPSASYLEVTPDSENDFGNYNCT 490
             + C+    P   ISW ++G   P  +  + I+   T     L +     +D G Y C 
Sbjct: 435 ALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI-----SDTGTYTCV 489

Query: 491 AVNRIGQESLEFIL-------------VQADTPSSPSIDQVEPYSSTAQVQFDEPEATGG 537
           A +  G+ S   +L               +D P  PS  QV   +  +     +P   G 
Sbjct: 490 ATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGT 549

Query: 538 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 597
           +P   Y  E  A  + V +S W          + T+ GL+P T Y   + A+N +GL + 
Sbjct: 550 LPASAYIIE--AFSQSVSNS-WQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDP 606

Query: 598 SAASEFKTQPVQGEPSAPKLEG----QMGEDGNSIKVNLIKQ--------------DDGG 639
           S  S+    PV+ +  +P  +G    Q+ ++   + V L                 D   
Sbjct: 607 SPMSD----PVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQP 662

Query: 640 SPIRHYLVRYRALS-----SEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQG 691
             I+ Y V YR  S     S W+  + ++P+    V++ +L     YE+ V       QG
Sbjct: 663 QFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLV-NLKKGVTYEIKVRPYFNEFQG 721

Query: 692 KSKAAHFVFRTSAQPTAIP 710
               +  V  T   P+A P
Sbjct: 722 MDSESKTVRTTEEAPSAPP 740



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 59/241 (24%), Positives = 92/241 (38%), Gaps = 29/241 (12%)

Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDG 367
           P+I    +   +   E  TL C+A G P P+I W      + +++     R  +     G
Sbjct: 31  PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDD--PRSHRMLLPSG 88

Query: 368 HMVVRS--HARVSSLTLKSIQYTDAGEYICTASNTIGQD-SQSMYLEVQYAPK--LQGPV 422
            +      H R S          D G Y+C A N +G+  S++  LEV        Q P 
Sbjct: 89  SLFFLRIVHGRRSK--------PDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 140

Query: 423 AVYTWEGNQVNITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSE 481
            V    G    + C+    +P  TI W +D ++        I I        L ++   +
Sbjct: 141 DVVVAAGEPAILECQPPRGHPEPTIYWKKD-KVRIDDKEERISI----RGGKLMISNTRK 195

Query: 482 NDFGNYNCTAVNRIGQ---ESLEFILVQADTPSSPSIDQV----EPYSSTAQVQFDEPEA 534
           +D G Y C   N +G+   +  E  + +  T     I+QV    E      QVQ D P+ 
Sbjct: 196 SDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGD-PQP 254

Query: 535 T 535
           T
Sbjct: 255 T 255


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score =  154 bits (390), Expect = 3e-37
 Identities = 194/738 (26%), Positives = 280/738 (37%), Gaps = 85/738 (11%)

Query: 26  PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
           PS   +S GE     C+  G      I W+   GE++      P   R+ +         
Sbjct: 35  PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92

Query: 81  LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
           +     +  D G+Y CV     G      A++ V I +   F+  P+      GE AV+ 
Sbjct: 93  IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151

Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
           C      P PTI WK  G  +   KD R I +    L I   +K+D G Y C G  +  G
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208

Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
           E   +  ++ V   P+   R +  N    +  S    C+A G P PT+ W KD  ++ + 
Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266

Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
               +Y   DD + L I+KV   D   Y C+AEN  G+ +A+  L V   P         
Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 321

Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARV 377
            + L   VT  CEA+G+P P+I WR   R  S     S+  P+            S ++ 
Sbjct: 322 VVALGRTVTFQCEATGNPQPAIFWR---REGSQNLLFSYQPPQSSSRF-------SVSQT 371

Query: 378 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGN 430
             LT+ ++Q +D G YIC   N  G      YLEV        P +  QGPV        
Sbjct: 372 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 431

Query: 431 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 490
              ++C     P  TI W +DG +L S+  S IK         L++      D G Y C 
Sbjct: 432 TFVLSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCI 487

Query: 491 AVNRIGQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEAT 535
           A    G+       E  EF + VQ          PS+PS  +V   S        +P   
Sbjct: 488 ASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLN 547

Query: 536 GGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLG 595
            G     Y  E          S W    E        I GLKP   Y   + A N  G+ 
Sbjct: 548 SGATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGIS 604

Query: 596 EISAASE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDDGGS 640
           + S  S+  KTQ   P        +++ ++G              +SI+V+    D    
Sbjct: 605 DPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQQSQ 663

Query: 641 PIRHYLVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGK 692
            I+ Y + YR        S+W   E+R P+  + V++  L     YE+         QG 
Sbjct: 664 YIQGYKILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEFQGA 722

Query: 693 SKAAHFVFRTSAQPTAIP 710
                F       P+A P
Sbjct: 723 DSEIKFAKTLEEAPSAPP 740



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 48/200 (24%), Positives = 76/200 (38%), Gaps = 21/200 (10%)

Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDG 367
           P+I    +   +   E  TL C+A G P P+I W      + +++     R  +     G
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDD--PRSHRMLLPSG 86

Query: 368 HMVVRS--HARVSSLTLKSIQYTDAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPV 422
            +      H R S          D G Y+C A N +G+    + S+ + +      Q P 
Sbjct: 87  SLFFLRIVHGRKSR--------PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138

Query: 423 AVYTWEGNQVNITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSE 481
            V    G    + C+    +P  TISW +DG  L   +        T     L +T   +
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRK 193

Query: 482 NDFGNYNCTAVNRIGQESLE 501
           +D G Y C   N +G+   E
Sbjct: 194 SDAGKYVCVGTNMVGERESE 213


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score =  154 bits (390), Expect = 3e-37
 Identities = 194/738 (26%), Positives = 280/738 (37%), Gaps = 85/738 (11%)

Query: 26  PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
           PS   +S GE     C+  G      I W+   GE++      P   R+ +         
Sbjct: 74  PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 131

Query: 81  LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
           +     +  D G+Y CV     G      A++ V I +   F+  P+      GE AV+ 
Sbjct: 132 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 190

Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
           C      P PTI WK  G  +   KD R I +    L I   +K+D G Y C G  +  G
Sbjct: 191 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 247

Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
           E   +  ++ V   P+   R +  N    +  S    C+A G P PT+ W KD  ++ + 
Sbjct: 248 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 305

Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
               +Y   DD + L I+KV   D   Y C+AEN  G+ +A+  L V   P         
Sbjct: 306 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 360

Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARV 377
            + L   VT  CEA+G+P P+I WR   R  S     S+  P+            S ++ 
Sbjct: 361 VVALGRTVTFQCEATGNPQPAIFWR---REGSQNLLFSYQPPQSSSRF-------SVSQT 410

Query: 378 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGN 430
             LT+ ++Q +D G YIC   N  G      YLEV        P +  QGPV        
Sbjct: 411 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 470

Query: 431 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 490
              ++C     P  TI W +DG +L S+  S IK         L++      D G Y C 
Sbjct: 471 TFVLSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCI 526

Query: 491 AVNRIGQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEAT 535
           A    G+       E  EF + VQ          PS+PS  +V   S        +P   
Sbjct: 527 ASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLN 586

Query: 536 GGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLG 595
            G     Y  E          S W    E        I GLKP   Y   + A N  G+ 
Sbjct: 587 SGATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGIS 643

Query: 596 EISAASE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDDGGS 640
           + S  S+  KTQ   P        +++ ++G              +SI+V+    D    
Sbjct: 644 DPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQQSQ 702

Query: 641 PIRHYLVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGK 692
            I+ Y + YR        S+W   E+R P+  + V++  L     YE+         QG 
Sbjct: 703 YIQGYKILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEFQGA 761

Query: 693 SKAAHFVFRTSAQPTAIP 710
                F       P+A P
Sbjct: 762 DSEIKFAKTLEEAPSAPP 779



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 48/200 (24%), Positives = 76/200 (38%), Gaps = 21/200 (10%)

Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDG 367
           P+I    +   +   E  TL C+A G P P+I W      + +++     R  +     G
Sbjct: 68  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDD--PRSHRMLLPSG 125

Query: 368 HMVVRS--HARVSSLTLKSIQYTDAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPV 422
            +      H R S          D G Y+C A N +G+    + S+ + +      Q P 
Sbjct: 126 SLFFLRIVHGRKSR--------PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 177

Query: 423 AVYTWEGNQVNITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSE 481
            V    G    + C+    +P  TISW +DG  L   +        T     L +T   +
Sbjct: 178 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRK 232

Query: 482 NDFGNYNCTAVNRIGQESLE 501
           +D G Y C   N +G+   E
Sbjct: 233 SDAGKYVCVGTNMVGERESE 252


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score =  150 bits (380), Expect = 4e-36
 Identities = 196/741 (26%), Positives = 285/741 (38%), Gaps = 88/741 (11%)

Query: 26  PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
           PS   +S GE     C+  G      I W+   GE++      P   R+ +         
Sbjct: 35  PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92

Query: 81  LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
           +     +  D G+Y CV     G      A++ V I +   F+  P+      GE AV+ 
Sbjct: 93  IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151

Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
           C      P PTI WK  G  +   KD R I +    L I   +K+D G Y C G  +  G
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208

Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
           E   +  ++ V   P+   R +  N    +  S    C+A G P PT+ W KD  ++ + 
Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266

Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314
               +Y   DD + L I+KV   D   Y C+AEN  G  E  AT+ ++V ++P    V+ 
Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321

Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSH 374
               + L   VT  CEA+G+P P+I WR   R  S     S+  P+            S 
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWR---REGSQNLLFSYQPPQSSSRF-------SV 371

Query: 375 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTW 427
           ++   LT+ ++Q +D G YIC   N  G      YLEV        P +  QGPV     
Sbjct: 372 SQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 431

Query: 428 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 487
                 ++C     P  TI W +DG +L S+  S IK         L++      D G Y
Sbjct: 432 VDGTFVLSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRY 487

Query: 488 NCTAVNRIGQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEP 532
            C A    G+       E  EF + VQ          PS+PS  +V   S        +P
Sbjct: 488 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP 547

Query: 533 EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGK 592
               G     Y  E          S W    E        I GLKP   Y   + A N  
Sbjct: 548 NLNSGATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY 604

Query: 593 GLGEISAASE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDD 637
           G+ + S  S+  KTQ   P        +++ ++G              +SI+V+    D 
Sbjct: 605 GISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQ 663

Query: 638 GGSPIRHYLVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQ 689
               I+ Y + YR        S+W   E+R P+  + V++  L     YE+         
Sbjct: 664 QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEF 722

Query: 690 QGKSKAAHFVFRTSAQPTAIP 710
           QG      F       P+A P
Sbjct: 723 QGADSEIKFAKTLEEAPSAPP 743



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 48/200 (24%), Positives = 76/200 (38%), Gaps = 21/200 (10%)

Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDG 367
           P+I    +   +   E  TL C+A G P P+I W      + +++     R  +     G
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDD--PRSHRMLLPSG 86

Query: 368 HMVVRS--HARVSSLTLKSIQYTDAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPV 422
            +      H R S          D G Y+C A N +G+    + S+ + +      Q P 
Sbjct: 87  SLFFLRIVHGRKSR--------PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138

Query: 423 AVYTWEGNQVNITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSE 481
            V    G    + C+    +P  TISW +DG  L   +        T     L +T   +
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRK 193

Query: 482 NDFGNYNCTAVNRIGQESLE 501
           +D G Y C   N +G+   E
Sbjct: 194 SDAGKYVCVGTNMVGERESE 213


>gi|224994171 roundabout 1 isoform c [Homo sapiens]
          Length = 1606

 Score =  150 bits (380), Expect = 4e-36
 Identities = 196/741 (26%), Positives = 285/741 (38%), Gaps = 88/741 (11%)

Query: 26  PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
           PS   +S GE     C+  G      I W+   GE++      P   R+ +         
Sbjct: 35  PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92

Query: 81  LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
           +     +  D G+Y CV     G      A++ V I +   F+  P+      GE AV+ 
Sbjct: 93  IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151

Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
           C      P PTI WK  G  +   KD R I +    L I   +K+D G Y C G  +  G
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208

Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
           E   +  ++ V   P+   R +  N    +  S    C+A G P PT+ W KD  ++ + 
Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266

Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314
               +Y   DD + L I+KV   D   Y C+AEN  G  E  AT+ ++V ++P    V+ 
Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321

Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSH 374
               + L   VT  CEA+G+P P+I WR   R  S     S+  P+            S 
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWR---REGSQNLLFSYQPPQSSSRF-------SV 371

Query: 375 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTW 427
           ++   LT+ ++Q +D G YIC   N  G      YLEV        P +  QGPV     
Sbjct: 372 SQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 431

Query: 428 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 487
                 ++C     P  TI W +DG +L S+  S IK         L++      D G Y
Sbjct: 432 VDGTFVLSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRY 487

Query: 488 NCTAVNRIGQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEP 532
            C A    G+       E  EF + VQ          PS+PS  +V   S        +P
Sbjct: 488 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP 547

Query: 533 EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGK 592
               G     Y  E          S W    E        I GLKP   Y   + A N  
Sbjct: 548 NLNSGATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY 604

Query: 593 GLGEISAASE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDD 637
           G+ + S  S+  KTQ   P        +++ ++G              +SI+V+    D 
Sbjct: 605 GISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQ 663

Query: 638 GGSPIRHYLVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQ 689
               I+ Y + YR        S+W   E+R P+  + V++  L     YE+         
Sbjct: 664 QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEF 722

Query: 690 QGKSKAAHFVFRTSAQPTAIP 710
           QG      F       P+A P
Sbjct: 723 QGADSEIKFAKTLEEAPSAPP 743



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 48/200 (24%), Positives = 76/200 (38%), Gaps = 21/200 (10%)

Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDG 367
           P+I    +   +   E  TL C+A G P P+I W      + +++     R  +     G
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDD--PRSHRMLLPSG 86

Query: 368 HMVVRS--HARVSSLTLKSIQYTDAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPV 422
            +      H R S          D G Y+C A N +G+    + S+ + +      Q P 
Sbjct: 87  SLFFLRIVHGRKSR--------PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138

Query: 423 AVYTWEGNQVNITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSE 481
            V    G    + C+    +P  TISW +DG  L   +        T     L +T   +
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRK 193

Query: 482 NDFGNYNCTAVNRIGQESLE 501
           +D G Y C   N +G+   E
Sbjct: 194 SDAGKYVCVGTNMVGERESE 213


>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
           sapiens]
          Length = 1562

 Score =  150 bits (380), Expect = 4e-36
 Identities = 196/741 (26%), Positives = 285/741 (38%), Gaps = 88/741 (11%)

Query: 26  PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
           PS   +S GE     C+  G      I W+   GE++      P   R+ +         
Sbjct: 35  PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92

Query: 81  LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
           +     +  D G+Y CV     G      A++ V I +   F+  P+      GE AV+ 
Sbjct: 93  IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151

Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
           C      P PTI WK  G  +   KD R I +    L I   +K+D G Y C G  +  G
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208

Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
           E   +  ++ V   P+   R +  N    +  S    C+A G P PT+ W KD  ++ + 
Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266

Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314
               +Y   DD + L I+KV   D   Y C+AEN  G  E  AT+ ++V ++P    V+ 
Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321

Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSH 374
               + L   VT  CEA+G+P P+I WR   R  S     S+  P+            S 
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWR---REGSQNLLFSYQPPQSSSRF-------SV 371

Query: 375 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTW 427
           ++   LT+ ++Q +D G YIC   N  G      YLEV        P +  QGPV     
Sbjct: 372 SQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 431

Query: 428 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 487
                 ++C     P  TI W +DG +L S+  S IK         L++      D G Y
Sbjct: 432 VDGTFVLSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRY 487

Query: 488 NCTAVNRIGQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEP 532
            C A    G+       E  EF + VQ          PS+PS  +V   S        +P
Sbjct: 488 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP 547

Query: 533 EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGK 592
               G     Y  E          S W    E        I GLKP   Y   + A N  
Sbjct: 548 NLNSGATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY 604

Query: 593 GLGEISAASE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDD 637
           G+ + S  S+  KTQ   P        +++ ++G              +SI+V+    D 
Sbjct: 605 GISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQ 663

Query: 638 GGSPIRHYLVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQ 689
               I+ Y + YR        S+W   E+R P+  + V++  L     YE+         
Sbjct: 664 QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEF 722

Query: 690 QGKSKAAHFVFRTSAQPTAIP 710
           QG      F       P+A P
Sbjct: 723 QGADSEIKFAKTLEEAPSAPP 743



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 48/200 (24%), Positives = 76/200 (38%), Gaps = 21/200 (10%)

Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDG 367
           P+I    +   +   E  TL C+A G P P+I W      + +++     R  +     G
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDD--PRSHRMLLPSG 86

Query: 368 HMVVRS--HARVSSLTLKSIQYTDAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPV 422
            +      H R S          D G Y+C A N +G+    + S+ + +      Q P 
Sbjct: 87  SLFFLRIVHGRKSR--------PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138

Query: 423 AVYTWEGNQVNITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSE 481
            V    G    + C+    +P  TISW +DG  L   +        T     L +T   +
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRK 193

Query: 482 NDFGNYNCTAVNRIGQESLE 501
           +D G Y C   N +G+   E
Sbjct: 194 SDAGKYVCVGTNMVGERESE 213


>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
           sapiens]
          Length = 1615

 Score =  150 bits (380), Expect = 4e-36
 Identities = 196/741 (26%), Positives = 285/741 (38%), Gaps = 88/741 (11%)

Query: 26  PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
           PS   +S GE     C+  G      I W+   GE++      P   R+ +         
Sbjct: 35  PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92

Query: 81  LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
           +     +  D G+Y CV     G      A++ V I +   F+  P+      GE AV+ 
Sbjct: 93  IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151

Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
           C      P PTI WK  G  +   KD R I +    L I   +K+D G Y C G  +  G
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208

Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
           E   +  ++ V   P+   R +  N    +  S    C+A G P PT+ W KD  ++ + 
Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266

Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314
               +Y   DD + L I+KV   D   Y C+AEN  G  E  AT+ ++V ++P    V+ 
Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321

Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSH 374
               + L   VT  CEA+G+P P+I WR   R  S     S+  P+            S 
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWR---REGSQNLLFSYQPPQSSSRF-------SV 371

Query: 375 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTW 427
           ++   LT+ ++Q +D G YIC   N  G      YLEV        P +  QGPV     
Sbjct: 372 SQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 431

Query: 428 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 487
                 ++C     P  TI W +DG +L S+  S IK         L++      D G Y
Sbjct: 432 VDGTFVLSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRY 487

Query: 488 NCTAVNRIGQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEP 532
            C A    G+       E  EF + VQ          PS+PS  +V   S        +P
Sbjct: 488 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP 547

Query: 533 EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGK 592
               G     Y  E          S W    E        I GLKP   Y   + A N  
Sbjct: 548 NLNSGATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY 604

Query: 593 GLGEISAASE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDD 637
           G+ + S  S+  KTQ   P        +++ ++G              +SI+V+    D 
Sbjct: 605 GISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQ 663

Query: 638 GGSPIRHYLVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQ 689
               I+ Y + YR        S+W   E+R P+  + V++  L     YE+         
Sbjct: 664 QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEF 722

Query: 690 QGKSKAAHFVFRTSAQPTAIP 710
           QG      F       P+A P
Sbjct: 723 QGADSEIKFAKTLEEAPSAPP 743



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 48/200 (24%), Positives = 76/200 (38%), Gaps = 21/200 (10%)

Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDG 367
           P+I    +   +   E  TL C+A G P P+I W      + +++     R  +     G
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDD--PRSHRMLLPSG 86

Query: 368 HMVVRS--HARVSSLTLKSIQYTDAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPV 422
            +      H R S          D G Y+C A N +G+    + S+ + +      Q P 
Sbjct: 87  SLFFLRIVHGRKSR--------PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138

Query: 423 AVYTWEGNQVNITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSE 481
            V    G    + C+    +P  TISW +DG  L   +        T     L +T   +
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRK 193

Query: 482 NDFGNYNCTAVNRIGQESLE 501
           +D G Y C   N +G+   E
Sbjct: 194 SDAGKYVCVGTNMVGERESE 213


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  149 bits (375), Expect = 1e-35
 Identities = 120/451 (26%), Positives = 185/451 (41%), Gaps = 40/451 (8%)

Query: 78   SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137
            S  L I  A    AG Y C      G  +   V + +    + K  P+       E+ ++
Sbjct: 2627 SGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 2685

Query: 138  VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
             C+      PTI W+ +G +V      +  VL    L+I      D G Y C  +  A  
Sbjct: 2686 PCEASGIPRPTITWQKEGLNVATGVSTQ--VLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2743

Query: 198  EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
             +     +++V VPP I+    + + +   G    L C A G PEP ++W KDG+ +   
Sbjct: 2744 AMG--KTRLVVQVPPVIE--NGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA 2799

Query: 258  EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
            E   K+     S +L +K ++  D   Y C AEN  G     +HL +   P  T +    
Sbjct: 2800 EG--KFTIQP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR 2856

Query: 318  AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARV 377
            ++ L +++ L C A G P P I W  + R ++          E     DG          
Sbjct: 2857 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT----------EGVSEQDGG--------- 2897

Query: 378  SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVNIT 435
            S+L   ++   D+G Y+C A N +G+     ++ V+ AP LQG    Y  E  G  + + 
Sbjct: 2898 STLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLD 2957

Query: 436  CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 495
            C V   P   I W +DG  L  S+  + ++ N      L +     +D G Y C A N +
Sbjct: 2958 CVVRGDPVPDIHWIKDGLPLRGSHLRH-QLQN----GSLTIRRTERDDAGRYQCLAENEM 3012

Query: 496  GQESLEFILVQADTPSSPSIDQVEPYSSTAQ 526
            G      ILV    P    + QVEP   T +
Sbjct: 3013 GVAKKVVILVLQSAP----VFQVEPQDMTVR 3039



 Score =  144 bits (364), Expect = 3e-34
 Identities = 132/489 (26%), Positives = 204/489 (41%), Gaps = 47/489 (9%)

Query: 31   ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
            + VG+     C+      +  ++W+  +G+ L   Q+  ++         L I  A + D
Sbjct: 1762 VRVGDKAVLSCETDA-LPEPTVTWYK-DGQPLVLAQRTQAL----RGGQRLEIQEAQVSD 1815

Query: 91   AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR-EGEDAVIVCDVVSSLPPTI 149
             G+Y C V+   G E+  T  + +     F+N  T    +  G   V+ CDV     PT+
Sbjct: 1816 KGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 1874

Query: 150  IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVN 209
             W  K R  +    V  +V     LQ+  ++    GTY C      + E   KD  V V 
Sbjct: 1875 TWL-KDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEAR-KDFVVAVL 1931

Query: 210  VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269
            V P I++           GQ V L C+A+G P P ++W KDG  + Q+       + D  
Sbjct: 1932 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 1991

Query: 270  SQLTIKKVDKNDEAEYICIAENKAGEQDATIH-LKVFAKPKITYVENQTAMELE---EQV 325
            S L +K +  +D   Y C+A N AGE DA +H + V   P I    + +   +    E V
Sbjct: 1992 S-LVLKGLRASDAGAYTCVAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 2049

Query: 326  TLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSI 385
            T+ C   G P   ++W           K     P  Q TL        H    +L +  +
Sbjct: 2050 TMVCPVRGSPPIHVSWL----------KDGLPLPLSQRTL-------LHGSGHTLRISKV 2092

Query: 386  QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA----VYTWEGNQVNITCEVFAY 441
            Q  DAG + C A++  G   ++  L+VQ  P L+ PV     V    G+ V + CE    
Sbjct: 2093 QLADAGIFTCVAASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEARGV 2151

Query: 442  PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 501
            P   +SW +DG+ L S +     +   PS   L++      D G Y+C AV+  G+    
Sbjct: 2152 PLPLVSWMKDGEPLLSQS-----LEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRH 2203

Query: 502  FILVQADTP 510
            F L   + P
Sbjct: 2204 FQLTVMEPP 2212



 Score =  143 bits (360), Expect = 8e-34
 Identities = 128/501 (25%), Positives = 217/501 (43%), Gaps = 68/501 (13%)

Query: 52   ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT---GEDGSESEA 108
            I W+  +G+ +TP+  R+ V+        L I    + D+G Y CV T   GED  +   
Sbjct: 1389 IRWYK-DGQPVTPSS-RLQVL---GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNV 1443

Query: 109  TVNVK-IFQKL-----MFKNAPTPQEFR----------EGEDAVIVCDVVSSLPPTIIWK 152
             + V  +FQK+      F+     +E R          E   A + CD  +  PP + W 
Sbjct: 1444 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 1503

Query: 153  HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI--NFKDIQVIVNV 210
             + + +    +V  ++     LQI  ++  + G Y C+    A  E+  ++   +++V  
Sbjct: 1504 REDQPLSAGDEVS-VLQGGRVLQIPLVRAENAGRYSCK----ASNEVGEDWLHYELLVLT 1558

Query: 211  PPTI--QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
            PP I     + +   T N   +V+L C A G P PT+SW ++G          +    +D
Sbjct: 1559 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSP---RLQVLED 1615

Query: 269  SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-NQTAMELEEQVTL 327
               L +   +  D A Y+C+AEN+AG  +    L+V   P+I  ++  Q    L   V+L
Sbjct: 1616 GQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSL 1675

Query: 328  TCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQY 387
             C+    P P +TW   ++ +S  E+               ++  +H    +L L   + 
Sbjct: 1676 PCDVHAHPNPEVTWYKDSQALSLGEEV-------------FLLPGTH----TLQLGRARL 1718

Query: 388  TDAGEYICTASNTIGQDSQSMYLEVQYAPKL----QGPV-AVYTWEGNQVNITCEVFAYP 442
            +D+G Y C A N  G+D + + L V   P      +GP  AV    G++  ++CE  A P
Sbjct: 1719 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 1778

Query: 443  SATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 502
              T++W++DGQ L  +     +         LE+     +D G Y+C   N  G+    F
Sbjct: 1779 EPTVTWYKDGQPLVLAQ----RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTF 1834

Query: 503  IL-VQA----DTPSSPSIDQV 518
             L VQ     + P + ++ QV
Sbjct: 1835 TLTVQVPPTFENPKTETVSQV 1855



 Score =  133 bits (334), Expect = 8e-31
 Identities = 116/452 (25%), Positives = 197/452 (43%), Gaps = 43/452 (9%)

Query: 81   LTIYNANIDDAGIYKCVVTGEDGSESE-ATVNVKIFQKLMF-KNAPTPQEFREGEDAVIV 138
            L +  A +   G Y C  +   G+ S+   + V +  ++   +  PT     +   A + 
Sbjct: 938  LYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 997

Query: 139  CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA-RG 197
            C+     PPT+ W+  G+ V  +  ++ +      L +   +    G Y C    LA R 
Sbjct: 998  CNATGKPPPTVTWERDGQPVGAELGLQ-LQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1056

Query: 198  EINFKDIQVIVNVPPTIQARQN-IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
            E  F   ++ V VPP +    + + N TA L   +TL+C+A G P P + W +  E +  
Sbjct: 1057 ERKF---ELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP 1113

Query: 257  EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
             ED   Y+ +     L + +  + D   Y C+A N+AGE      ++V   P I   + +
Sbjct: 1114 GED--TYLLA-GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLE 1170

Query: 317  TAMELEEQVT--LTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSH 374
              +++ +  T  L C  +G P P +TW    R ++  + A    P      DG ++    
Sbjct: 1171 EVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD-AHHISP------DGVLLQVLQ 1223

Query: 375  ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPV------AVYTWE 428
            A +SS          AG Y C A+N +G+ ++   L V  AP + G         V    
Sbjct: 1224 ANLSS----------AGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTV 1273

Query: 429  GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
             N +++ CE  A+PS  I+W +DG    +S   NI++   P    L++    + D G Y 
Sbjct: 1274 NNPISLICEALAFPSPNITWMKDGAPFEASR--NIQL--LPGTHGLQILNAQKEDAGQYT 1329

Query: 489  CTAVNRIGQESLEFILVQADTPSSPSIDQVEP 520
            C   N +G E+++   V+   P  PSI + +P
Sbjct: 1330 CVVTNELG-EAVKNYHVEVLIP--PSISKDDP 1358



 Score =  128 bits (321), Expect = 3e-29
 Identities = 123/483 (25%), Positives = 186/483 (38%), Gaps = 38/483 (7%)

Query: 81   LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
            L I   ++ D GIY C  T   G ES+  V +K+      +  P  +   E     + C 
Sbjct: 568  LQIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 626

Query: 141  VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC-EGRILARGEI 199
                 PP + W  KG   +       + +    L+I   + +D G+YRC    +    E+
Sbjct: 627  ASGVPPPDVSW-FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 685

Query: 200  NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
             +    + VNVPP I    ++      +   V L C+A G P PT+ W KDG  +     
Sbjct: 686  RYG---LRVNVPPRITLPPSLPGPVL-VNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGT 741

Query: 260  DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
                +F      LT+     +D   Y C+A +  GE    + L+V   P I   E   ++
Sbjct: 742  PGLQVFPG-GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSV 800

Query: 320  ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS 379
               E V L C++   P P ++W              W      E   G   V   A  + 
Sbjct: 801  VANESVALECQSHAMPPPVLSW--------------WKDGRPLEPRPG---VHLSADKAL 843

Query: 380  LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP--KLQGPVAVYTWEGNQVNITCE 437
            L +      DAG Y C A N  G   +   L V  AP   L+    +   EG+   ++CE
Sbjct: 844  LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCE 903

Query: 438  VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 497
                P   ISW +DGQ LP        +       YL     ++   G Y C   N +G 
Sbjct: 904  CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE--GTYTCECSNVVGN 961

Query: 498  ESLEFILVQADTPSSPSI-DQVEPYSSTAQVQFD----EPEATG-GVPILKYKAEWRAVG 551
             S +   +Q +    P I    EP +  + VQ      E  ATG   P + ++ + + VG
Sbjct: 962  SSQD---LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVG 1018

Query: 552  EEV 554
             E+
Sbjct: 1019 AEL 1021



 Score =  127 bits (320), Expect = 3e-29
 Identities = 124/478 (25%), Positives = 195/478 (40%), Gaps = 66/478 (13%)

Query: 34   GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
            GE    +C V G +    +SW   +G  L  +Q+ +       S  TL I    + DAGI
Sbjct: 2046 GELVTMVCPVRG-SPPIHVSWLK-DGLPLPLSQRTLL----HGSGHTLRISKVQLADAGI 2099

Query: 94   YKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP------ 146
            + CV     G ++   T+ V++   L       P EF+   D V+V   +  LP      
Sbjct: 2100 FTCVAASPAGVADRNFTLQVQVPPVL------EPVEFQN--DVVVVRGSLVELPCEARGV 2151

Query: 147  --PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204
              P + W   G  ++ +      +     LQ+  +   D GTY C   +   GE   +  
Sbjct: 2152 PLPLVSWMKDGEPLLSQS-----LEQGPSLQLEAVGAGDSGTYSCVA-VSEAGEAR-RHF 2204

Query: 205  QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264
            Q+ V  PP I+        +   G  + L+CDA+G P+P ++W KDG+ + + E++ +  
Sbjct: 2205 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSR-- 2262

Query: 265  FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--LE 322
                      + +   D   Y C+AE+ AG  + +  ++V A P I        +     
Sbjct: 2263 --------ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP 2314

Query: 323  EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTL 382
             Q+ L C    +P P ITW      I  +E A    PE               R   L L
Sbjct: 2315 GQLVLECSVEAEPAPKITWHRD--GIVLQEDAHTQFPE---------------RGRFLQL 2357

Query: 383  KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAY 441
            +++   D+G+Y CTA N  G  S +  +E+   P ++ GP AV         + C+    
Sbjct: 2358 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 2417

Query: 442  PSATISWFRDG-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 498
            P+  +SW +D   L P S    I     P  S L + P    D G+Y C A N  G +
Sbjct: 2418 PAPLVSWRKDRVPLDPRSPRFEI----LPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 2470



 Score =  127 bits (319), Expect = 4e-29
 Identities = 106/456 (23%), Positives = 186/456 (40%), Gaps = 65/456 (14%)

Query: 90   DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPP 147
            D+G+Y C+ + E G E+    +V++      +N    +  +  +G+ A ++C+V     P
Sbjct: 1135 DSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP 1193

Query: 148  TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
             + W   GR  + + D   I      LQ+     +  G Y C     A GE   K  Q+ 
Sbjct: 1194 KLTWFKDGRP-LARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN-AVGE-KTKHFQLS 1250

Query: 208  VNVPPTI-----QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
            V + PTI      +    V  T N    ++L+C+A  FP P ++W KDG   E   + + 
Sbjct: 1251 VLLAPTILGGAEDSADEEVTVTVN--NPISLICEALAFPSPNITWMKDGAPFEASRNIQ- 1307

Query: 263  YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-------N 315
                  +  L I    K D  +Y C+  N+ GE     H++V   P I+  +        
Sbjct: 1308 --LLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVK 1365

Query: 316  QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHA 375
            +   ++   +TL CE+   P P+I W    + ++   +               + V    
Sbjct: 1366 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSR---------------LQVLGEG 1410

Query: 376  RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ---------------- 419
            R+  L ++  Q +D+G Y+C A+N  G+D Q   + +Q  P  Q                
Sbjct: 1411 RL--LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREE 1468

Query: 420  ---GPVAVY--TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYL 474
               G V  Y    E N   + C+  A P   ++W+R+ Q L + +  ++          L
Sbjct: 1469 EARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV----LQGGRVL 1524

Query: 475  EVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 510
            ++      + G Y+C A N +G++ L + L+    P
Sbjct: 1525 QIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPP 1560



 Score =  126 bits (317), Expect = 8e-29
 Identities = 114/441 (25%), Positives = 172/441 (39%), Gaps = 54/441 (12%)

Query: 81   LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
            L I +A+ +DAG Y C+     GS    T  + +    + +N        EG  A + C 
Sbjct: 2720 LRIAHASPEDAGNYLCIAKNSAGSAMGKT-RLVVQVPPVIENGLPDLSTTEGSHAFLPCK 2778

Query: 141  VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195
               S  P I W   G+ V    + +F +  +  L ++ ++  D GTY C      GR   
Sbjct: 2779 ARGSPEPNITWDKDGQPVS-GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR 2837

Query: 196  RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
            R  +    + V   +P     R         LG  + L C A G P P + WT +   + 
Sbjct: 2838 RVHLTILVLPVFTTLPGDRSLR---------LGDRLWLRCAARGSPTPRIGWTVNDRPVT 2888

Query: 256  QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
            +   ++     D  S L    V + D   Y+C AEN+ G   A   + V   P +     
Sbjct: 2889 EGVSEQ-----DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAF 2943

Query: 316  QTAME-LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSH 374
               +E +   + L C   GDP+P I W                        DG  +  SH
Sbjct: 2944 SYLVEPVGGSIQLDCVVRGDPVPDIHW----------------------IKDGLPLRGSH 2981

Query: 375  ARVS----SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEG 429
             R      SLT++  +  DAG Y C A N +G   + + L +Q AP  Q  P  +    G
Sbjct: 2982 LRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSG 3041

Query: 430  NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 489
            + V + C+    P+ TI W + GQ L +S     ++   P  S L +      D G Y+C
Sbjct: 3042 DDVALRCQATGEPTPTIEWLQAGQPLRASR----RLRTLPDGS-LWLENVETGDAGTYDC 3096

Query: 490  TAVNRIGQESLEFILVQADTP 510
             A N +G  +    LV    P
Sbjct: 3097 VAHNLLGSATARAFLVVRGEP 3117



 Score =  117 bits (294), Expect = 3e-26
 Identities = 119/495 (24%), Positives = 195/495 (39%), Gaps = 51/495 (10%)

Query: 26   PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
            P++  ++ G     LC   G  +  +I+W   +G+ LT  +        ++S +T  +  
Sbjct: 2220 PTELSLTPGAPMELLCDAQGTPQP-NITWHK-DGQALTRLE--------NNSRATRVL-- 2267

Query: 86   ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144
              + DAG+Y C+     G+ E    V V+    ++    P           V+ C V + 
Sbjct: 2268 -RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 2326

Query: 145  LPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARG-EINFK 202
              P I W   G  ++L++D          +LQ++ +   D G Y C  R  A    + F+
Sbjct: 2327 PAPKITWHRDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2384

Query: 203  DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
               V ++  PTI++    VN + N  Q+  L C A+G P P +SW KD   ++      +
Sbjct: 2385 ---VEIHTVPTIRSGPPAVNVSVN--QTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE 2439

Query: 263  YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELE 322
             +       L I+ V   D   Y+C+A N AG       L+V   P I    +   +   
Sbjct: 2440 IL---PEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2496

Query: 323  EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS--L 380
                L CEASG P P + W              W   +K   LD  +   ++  + S  L
Sbjct: 2497 TPALLPCEASGSPKPLVVW--------------WKDGQK---LDFRLQQGAYRLLPSNAL 2539

Query: 381  TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-WEGNQVNITCEVF 439
             L +    D+ ++ C  SN +G+  +   + V   P +      +T      V +TC   
Sbjct: 2540 LLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHST 2599

Query: 440  AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QE 498
              P+ T+SW + G  L +        Y    +  LE+        G Y C+A N  G   
Sbjct: 2600 GIPAPTVSWSKAGAQLGARGSG----YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 2655

Query: 499  SLEFILVQADTPSSP 513
               F+ VQA     P
Sbjct: 2656 KHVFLTVQASPVVKP 2670



 Score =  117 bits (293), Expect = 5e-26
 Identities = 88/306 (28%), Positives = 126/306 (41%), Gaps = 41/306 (13%)

Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFS--- 266
           VPP+I+      N +   GQS+TL CDA GFP P + W KD + +        Y +    
Sbjct: 15  VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGW 74

Query: 267 ---------DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV-ENQ 316
                    D+   L   ++ + D   Y C AEN+AG      HL V   P +      Q
Sbjct: 75  GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQ 134

Query: 317 TAMELE-EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDG--HMVVRS 373
             + L    V L C  SG P P + W                  ++Q  L G  H+ V+ 
Sbjct: 135 EVLGLAGADVELQCWTSGVPTPQVEW----------------TKDRQPVLPGGPHLQVQE 178

Query: 374 HARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG---PVAVYTWEGN 430
             +V  +T   +   D G Y C A +  GQ ++   L V   P + G      V   E +
Sbjct: 179 DGQVLRITGSHV--GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDH 236

Query: 431 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 490
            V + CE    P+  I+WF+DG LLP+S     K+  T     L++     +D G Y C 
Sbjct: 237 LVQLLCEARGVPTPNITWFKDGALLPTST----KVVYTRGGRQLQLGRAQSSDAGVYTCK 292

Query: 491 AVNRIG 496
           A N +G
Sbjct: 293 ASNAVG 298



 Score =  110 bits (276), Expect = 4e-24
 Identities = 107/462 (23%), Positives = 171/462 (37%), Gaps = 53/462 (11%)

Query: 51  DISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
           D+ W    G +L             D   +L        D+G+Y C    + G+ ++   
Sbjct: 71  DLGWGQVGGHRLL------------DEGQSLHFPRIQEGDSGLYSCRAENQAGT-AQRDF 117

Query: 111 NVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIV 168
           ++ +        A   QE     G D  + C       P + W    + V+       + 
Sbjct: 118 HLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQ 177

Query: 169 LSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLG 228
                L+I G    DEG Y+C     A  +   +D Q+ V+ PPTI              
Sbjct: 178 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQA--RDFQLRVHAPPTIWGSNETGEVAVMED 235

Query: 229 QSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICI 288
             V L+C+A G P P ++W KDG  +       K +++    QL + +   +D   Y C 
Sbjct: 236 HLVQLLCEARGVPTPNITWFKDGALL---PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCK 292

Query: 289 AENKAGEQDATIHLKVFAKPKI------TYVENQTAMELEEQVTLTCEASGDPIPSITWR 342
           A N  G  +    L V+  P I       YV    A      V L C A G P P+++W 
Sbjct: 293 ASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA---GRPVALECVARGHPSPTLSWH 349

Query: 343 TSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 402
                ++          E +   DG          S L L+S     +G Y C AS+  G
Sbjct: 350 HEGLPVAESN-------ESRLETDG----------SVLRLESPGEASSGLYSCVASSPAG 392

Query: 403 QDSQSMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSN 459
           +      +EVQ  P+L   +G   V T  G  + + C+    P  TI W ++G+  P+  
Sbjct: 393 EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEE 450

Query: 460 YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 501
            + +++      + L +     +  G + C A N  G    E
Sbjct: 451 LAGVQV--ASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE 490



 Score =  108 bits (271), Expect = 2e-23
 Identities = 113/487 (23%), Positives = 189/487 (38%), Gaps = 40/487 (8%)

Query: 29  GEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNA 86
           GE++V E      LC+  G     +I+WF      L P   ++           L +  A
Sbjct: 228 GEVAVMEDHLVQLLCEARG-VPTPNITWFKDGA--LLPTSTKVVYT---RGGRQLQLGRA 281

Query: 87  NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA---PTPQEFREGEDAVIVCDVVS 143
              DAG+Y C  +   G+  +AT  + ++     + A   P   +   G    + C    
Sbjct: 282 QSSDAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 340

Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
              PT+ W H+G  V    + R +    + L++    +   G Y C     A GE   + 
Sbjct: 341 HPSPTLSWHHEGLPVAESNESR-LETDGSVLRLESPGEASSGLYSCVASSPA-GEAVLQ- 397

Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
             V V VPP +   + +   T  +GQ + L C A G P PT+ W ++G   E+    +  
Sbjct: 398 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQ-- 455

Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVE-NQTAME 320
             +   + L I  V+ +    + C A N+AG   A + + V  +  P +  V   Q    
Sbjct: 456 -VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWG 514

Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKAS----WTRPEKQETLDGHMVVRSHAR 376
            E   +    A+ DP     W    +    E   S    W  P          +  +++ 
Sbjct: 515 XEHHSSF--PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTG--------IPVAYSL 564

Query: 377 VSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNIT 435
              L ++ +   D G Y C A+N  G+  + + L+V   P ++ GPV     E   V + 
Sbjct: 565 PPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLE 624

Query: 436 CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 495
           C     P   +SWF+  Q  P S++  + +  +     L +     +D G+Y C A N  
Sbjct: 625 CLASGVPPPDVSWFKGHQ--PVSSWMGVTV--SVDGRVLRIEQAQLSDAGSYRCVASNVA 680

Query: 496 GQESLEF 502
           G   L +
Sbjct: 681 GSTELRY 687



 Score =  104 bits (260), Expect = 3e-22
 Identities = 92/389 (23%), Positives = 161/389 (41%), Gaps = 45/389 (11%)

Query: 34   GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
            G   F  C+  G + + +I+W   +G+ ++  + + ++      S  L + N    DAG 
Sbjct: 2770 GSHAFLPCKARG-SPEPNITW-DKDGQPVSGAEGKFTI----QPSGELLVKNLEGQDAGT 2823

Query: 94   YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
            Y C      G  +   V++ I    +F   P  +  R G+   + C    S  P I W  
Sbjct: 2824 YTCTAENAVG-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 2882

Query: 154  KGRDV---ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC--EGRILARGEINFKDIQVIV 208
              R V   + ++D        + LQ   + + D GTY C  E R+     ++F    V V
Sbjct: 2883 NDRPVTEGVSEQD------GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF----VHV 2932

Query: 209  NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
               P +Q  +        +G S+ L C   G P P + W KDG  +       +      
Sbjct: 2933 KEAPVLQG-EAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQL----Q 2987

Query: 269  SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
            +  LTI++ +++D   Y C+AEN+ G     + L + + P          +   + V L 
Sbjct: 2988 NGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 3047

Query: 329  CEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYT 388
            C+A+G+P P+I W  + + + +  +   T P+                  SL L++++  
Sbjct: 3048 CQATGEPTPTIEWLQAGQPLRASRRLR-TLPD-----------------GSLWLENVETG 3089

Query: 389  DAGEYICTASNTIGQDSQSMYLEVQYAPK 417
            DAG Y C A N +G  +   +L V+  P+
Sbjct: 3090 DAGTYDCVAHNLLGSATARAFLVVRGEPQ 3118



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 50/189 (26%), Positives = 77/189 (40%), Gaps = 16/189 (8%)

Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSE---EKASWTRPEKQETLDGHMVVRSHARVSS 379
           + +TL C+A+G P+P I W    + +          W     Q  + GH ++       S
Sbjct: 34  QSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQ--VGGHRLLDEG---QS 88

Query: 380 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA---VYTWEGNQVNITC 436
           L    IQ  D+G Y C A N  G   +  +L V   P + G  A   V    G  V + C
Sbjct: 89  LHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQC 148

Query: 437 EVFAYPSATISWFRDGQ-LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 495
                P+  + W +D Q +LP   +  ++         L +T     D G Y C A +  
Sbjct: 149 WTSGVPTPQVEWTKDRQPVLPGGPHLQVQ----EDGQVLRITGSHVGDEGRYQCVAFSPA 204

Query: 496 GQESLEFIL 504
           GQ++ +F L
Sbjct: 205 GQQARDFQL 213


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  148 bits (374), Expect = 2e-35
 Identities = 120/451 (26%), Positives = 185/451 (41%), Gaps = 40/451 (8%)

Query: 78   SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137
            S  L I  A    AG Y C      G  +   V + +    + K  P+       E+ ++
Sbjct: 2718 SGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 2776

Query: 138  VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
             C+      PTI W+ +G +V      +  VL    L+I      D G Y C  +  A  
Sbjct: 2777 PCEASGIPRPTITWQKEGLNVATGVSTQ--VLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2834

Query: 198  EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
             +     +++V VPP I+    + + +   G    L C A G PEP ++W KDG+ +   
Sbjct: 2835 AMG--KTRLVVQVPPVIE--NGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA 2890

Query: 258  EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
            E   K+     S +L +K ++  D   Y C AEN  G     +HL +   P  T +    
Sbjct: 2891 EG--KFTIQP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR 2947

Query: 318  AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARV 377
            ++ L +++ L C A G P P I W  + R ++          E     DG          
Sbjct: 2948 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT----------EGVSEQDGG--------- 2988

Query: 378  SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVNIT 435
            S+L   ++   D+G Y+C A N +G+     ++ V+ AP LQG    Y  E  G  + + 
Sbjct: 2989 STLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLD 3048

Query: 436  CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 495
            C V   P   I W +DG  L  S+  + ++ N      L +     +D G Y C A N +
Sbjct: 3049 CVVRGDPVPDIHWIKDGLPLRGSHLRH-QLQN----GSLTIHRTERDDAGRYQCLAENEM 3103

Query: 496  GQESLEFILVQADTPSSPSIDQVEPYSSTAQ 526
            G      ILV    P    + QVEP   T +
Sbjct: 3104 GVAKKVVILVLQSAP----VFQVEPQDMTVR 3130



 Score =  144 bits (364), Expect = 3e-34
 Identities = 132/489 (26%), Positives = 204/489 (41%), Gaps = 47/489 (9%)

Query: 31   ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
            + VG+     C+      +  ++W+  +G+ L   Q+  ++         L I  A + D
Sbjct: 1853 VRVGDKAVLSCETDA-LPEPTVTWYK-DGQPLVLAQRTQAL----RGGQRLEIQEAQVSD 1906

Query: 91   AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR-EGEDAVIVCDVVSSLPPTI 149
             G+Y C V+   G E+  T  + +     F+N  T    +  G   V+ CDV     PT+
Sbjct: 1907 KGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 1965

Query: 150  IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVN 209
             W  K R  +    V  +V     LQ+  ++    GTY C      + E   KD  V V 
Sbjct: 1966 TWL-KDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEAR-KDFVVAVL 2022

Query: 210  VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269
            V P I++           GQ V L C+A+G P P ++W KDG  + Q+       + D  
Sbjct: 2023 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 2082

Query: 270  SQLTIKKVDKNDEAEYICIAENKAGEQDATIH-LKVFAKPKITYVENQTAMELE---EQV 325
            S L +K +  +D   Y C+A N AGE DA +H + V   P I    + +   +    E V
Sbjct: 2083 S-LVLKGLRASDAGAYTCVAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 2140

Query: 326  TLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSI 385
            T+ C   G P   ++W           K     P  Q TL        H    +L +  +
Sbjct: 2141 TMVCPVRGSPPIHVSWL----------KDGLPLPLSQRTL-------LHGSGHTLRISKV 2183

Query: 386  QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA----VYTWEGNQVNITCEVFAY 441
            Q  DAG + C A++  G   ++  L+VQ  P L+ PV     V    G+ V + CE    
Sbjct: 2184 QLADAGIFTCVAASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEARGV 2242

Query: 442  PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 501
            P   +SW +DG+ L S +     +   PS   L++      D G Y+C AV+  G+    
Sbjct: 2243 PLPLVSWMKDGEPLLSQS-----LEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRH 2294

Query: 502  FILVQADTP 510
            F L   + P
Sbjct: 2295 FQLTVMEPP 2303



 Score =  143 bits (360), Expect = 8e-34
 Identities = 128/501 (25%), Positives = 217/501 (43%), Gaps = 68/501 (13%)

Query: 52   ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT---GEDGSESEA 108
            I W+  +G+ +TP+  R+ V+        L I    + D+G Y CV T   GED  +   
Sbjct: 1480 IRWYK-DGQPVTPSS-RLQVL---GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNV 1534

Query: 109  TVNVK-IFQKL-----MFKNAPTPQEFR----------EGEDAVIVCDVVSSLPPTIIWK 152
             + V  +FQK+      F+     +E R          E   A + CD  +  PP + W 
Sbjct: 1535 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 1594

Query: 153  HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI--NFKDIQVIVNV 210
             + + +    +V  ++     LQI  ++  + G Y C+    A  E+  ++   +++V  
Sbjct: 1595 REDQPLSAGDEVS-VLQGGRVLQIPLVRAENAGRYSCK----ASNEVGEDWLHYELLVLT 1649

Query: 211  PPTI--QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
            PP I     + +   T N   +V+L C A G P PT+SW ++G          +    +D
Sbjct: 1650 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSP---RLQVLED 1706

Query: 269  SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-NQTAMELEEQVTL 327
               L +   +  D A Y+C+AEN+AG  +    L+V   P+I  ++  Q    L   V+L
Sbjct: 1707 GQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSL 1766

Query: 328  TCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQY 387
             C+    P P +TW   ++ +S  E+               ++  +H    +L L   + 
Sbjct: 1767 PCDVHAHPNPEVTWYKDSQALSLGEEV-------------FLLPGTH----TLQLGRARL 1809

Query: 388  TDAGEYICTASNTIGQDSQSMYLEVQYAPKL----QGPV-AVYTWEGNQVNITCEVFAYP 442
            +D+G Y C A N  G+D + + L V   P      +GP  AV    G++  ++CE  A P
Sbjct: 1810 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 1869

Query: 443  SATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 502
              T++W++DGQ L  +     +         LE+     +D G Y+C   N  G+    F
Sbjct: 1870 EPTVTWYKDGQPLVLAQ----RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTF 1925

Query: 503  IL-VQA----DTPSSPSIDQV 518
             L VQ     + P + ++ QV
Sbjct: 1926 TLTVQVPPTFENPKTETVSQV 1946



 Score =  133 bits (334), Expect = 8e-31
 Identities = 116/452 (25%), Positives = 197/452 (43%), Gaps = 43/452 (9%)

Query: 81   LTIYNANIDDAGIYKCVVTGEDGSESE-ATVNVKIFQKLMF-KNAPTPQEFREGEDAVIV 138
            L +  A +   G Y C  +   G+ S+   + V +  ++   +  PT     +   A + 
Sbjct: 1029 LYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 1088

Query: 139  CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA-RG 197
            C+     PPT+ W+  G+ V  +  ++ +      L +   +    G Y C    LA R 
Sbjct: 1089 CNATGKPPPTVTWERDGQPVGAELGLQ-LQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1147

Query: 198  EINFKDIQVIVNVPPTIQARQN-IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
            E  F   ++ V VPP +    + + N TA L   +TL+C+A G P P + W +  E +  
Sbjct: 1148 ERKF---ELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP 1204

Query: 257  EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
             ED   Y+ +     L + +  + D   Y C+A N+AGE      ++V   P I   + +
Sbjct: 1205 GED--TYLLA-GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLE 1261

Query: 317  TAMELEEQVT--LTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSH 374
              +++ +  T  L C  +G P P +TW    R ++  + A    P      DG ++    
Sbjct: 1262 EVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD-AHHISP------DGVLLQVLQ 1314

Query: 375  ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPV------AVYTWE 428
            A +SS          AG Y C A+N +G+ ++   L V  AP + G         V    
Sbjct: 1315 ANLSS----------AGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTV 1364

Query: 429  GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
             N +++ CE  A+PS  I+W +DG    +S   NI++   P    L++    + D G Y 
Sbjct: 1365 NNPISLICEALAFPSPNITWMKDGAPFEASR--NIQL--LPGTHGLQILNAQKEDAGQYT 1420

Query: 489  CTAVNRIGQESLEFILVQADTPSSPSIDQVEP 520
            C   N +G E+++   V+   P  PSI + +P
Sbjct: 1421 CVVTNELG-EAVKNYHVEVLIP--PSISKDDP 1449



 Score =  129 bits (323), Expect = 2e-29
 Identities = 123/483 (25%), Positives = 188/483 (38%), Gaps = 38/483 (7%)

Query: 81   LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
            L I   ++ D GIY C  T   G ES+  V +K+      +  P  +   E     + C 
Sbjct: 659  LQIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 717

Query: 141  VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC-EGRILARGEI 199
                 PP + W  KG   +       + +    L+I   + +D G+YRC    +    E+
Sbjct: 718  ASGVPPPDVSW-FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 776

Query: 200  NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
             +    + VNVPP I    ++      +   V L C+A G P PT+ W KDG  +     
Sbjct: 777  RYG---LRVNVPPRITLPPSLPGPVL-VNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGT 832

Query: 260  DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
                +F      LT+     +D   Y C+A +  GE    + L+V   P I   E   ++
Sbjct: 833  PGLQVFPG-GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSV 891

Query: 320  ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS 379
               E V L C++   P P ++W              W      E   G   V   A  + 
Sbjct: 892  VANESVALECQSHAMPPPVLSW--------------WKDGRPLEPRPG---VHLSADKAL 934

Query: 380  LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP--KLQGPVAVYTWEGNQVNITCE 437
            L +      DAG Y C A N  G+  +   L V  AP   L+    +   EG+  +++CE
Sbjct: 935  LQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCE 994

Query: 438  VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 497
                P   ISW +DGQ LP        +       YL     ++   G Y C   N +G 
Sbjct: 995  CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE--GTYTCECSNVVGN 1052

Query: 498  ESLEFILVQADTPSSPSI-DQVEPYSSTAQVQFD----EPEATG-GVPILKYKAEWRAVG 551
             S +   +Q +    P I    EP +  + VQ      E  ATG   P + ++ + + VG
Sbjct: 1053 SSQD---LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVG 1109

Query: 552  EEV 554
             E+
Sbjct: 1110 AEL 1112



 Score =  127 bits (320), Expect = 3e-29
 Identities = 124/478 (25%), Positives = 195/478 (40%), Gaps = 66/478 (13%)

Query: 34   GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
            GE    +C V G +    +SW   +G  L  +Q+ +       S  TL I    + DAGI
Sbjct: 2137 GELVTMVCPVRG-SPPIHVSWLK-DGLPLPLSQRTLL----HGSGHTLRISKVQLADAGI 2190

Query: 94   YKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP------ 146
            + CV     G ++   T+ V++   L       P EF+   D V+V   +  LP      
Sbjct: 2191 FTCVAASPAGVADRNFTLQVQVPPVL------EPVEFQN--DVVVVRGSLVELPCEARGV 2242

Query: 147  --PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204
              P + W   G  ++ +      +     LQ+  +   D GTY C   +   GE   +  
Sbjct: 2243 PLPLVSWMKDGEPLLSQS-----LEQGPSLQLEAVGAGDSGTYSCVA-VSEAGEAR-RHF 2295

Query: 205  QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264
            Q+ V  PP I+        +   G  + L+CDA+G P+P ++W KDG+ + + E++ +  
Sbjct: 2296 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSR-- 2353

Query: 265  FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--LE 322
                      + +   D   Y C+AE+ AG  + +  ++V A P I        +     
Sbjct: 2354 --------ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP 2405

Query: 323  EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTL 382
             Q+ L C    +P P ITW      I  +E A    PE               R   L L
Sbjct: 2406 GQLVLECSVEAEPAPKITWHRD--GIVLQEDAHTQFPE---------------RGRFLQL 2448

Query: 383  KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAY 441
            +++   D+G+Y CTA N  G  S +  +E+   P ++ GP AV         + C+    
Sbjct: 2449 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 2508

Query: 442  PSATISWFRDG-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 498
            P+  +SW +D   L P S    I     P  S L + P    D G+Y C A N  G +
Sbjct: 2509 PAPLVSWRKDRVPLDPRSPRFEI----LPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 2561



 Score =  127 bits (319), Expect = 4e-29
 Identities = 106/456 (23%), Positives = 186/456 (40%), Gaps = 65/456 (14%)

Query: 90   DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPP 147
            D+G+Y C+ + E G E+    +V++      +N    +  +  +G+ A ++C+V     P
Sbjct: 1226 DSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP 1284

Query: 148  TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
             + W   GR  + + D   I      LQ+     +  G Y C     A GE   K  Q+ 
Sbjct: 1285 KLTWFKDGRP-LARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN-AVGE-KTKHFQLS 1341

Query: 208  VNVPPTI-----QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
            V + PTI      +    V  T N    ++L+C+A  FP P ++W KDG   E   + + 
Sbjct: 1342 VLLAPTILGGAEDSADEEVTVTVN--NPISLICEALAFPSPNITWMKDGAPFEASRNIQ- 1398

Query: 263  YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-------N 315
                  +  L I    K D  +Y C+  N+ GE     H++V   P I+  +        
Sbjct: 1399 --LLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVK 1456

Query: 316  QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHA 375
            +   ++   +TL CE+   P P+I W    + ++   +               + V    
Sbjct: 1457 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSR---------------LQVLGEG 1501

Query: 376  RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ---------------- 419
            R+  L ++  Q +D+G Y+C A+N  G+D Q   + +Q  P  Q                
Sbjct: 1502 RL--LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREE 1559

Query: 420  ---GPVAVY--TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYL 474
               G V  Y    E N   + C+  A P   ++W+R+ Q L + +  ++          L
Sbjct: 1560 EARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV----LQGGRVL 1615

Query: 475  EVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 510
            ++      + G Y+C A N +G++ L + L+    P
Sbjct: 1616 QIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPP 1651



 Score =  125 bits (314), Expect = 2e-28
 Identities = 114/441 (25%), Positives = 171/441 (38%), Gaps = 54/441 (12%)

Query: 81   LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
            L I +A+ +DAG Y C+     GS    T  + +    + +N        EG  A + C 
Sbjct: 2811 LRIAHASPEDAGNYLCIAKNSAGSAMGKT-RLVVQVPPVIENGLPDLSTTEGSHAFLPCK 2869

Query: 141  VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195
               S  P I W   G+ V    + +F +  +  L ++ ++  D GTY C      GR   
Sbjct: 2870 ARGSPEPNITWDKDGQPVS-GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR 2928

Query: 196  RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
            R  +    + V   +P     R         LG  + L C A G P P + WT +   + 
Sbjct: 2929 RVHLTILVLPVFTTLPGDRSLR---------LGDRLWLRCAARGSPTPRIGWTVNDRPVT 2979

Query: 256  QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
            +   ++     D  S L    V + D   Y+C AEN+ G   A   + V   P +     
Sbjct: 2980 EGVSEQ-----DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAF 3034

Query: 316  QTAME-LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSH 374
               +E +   + L C   GDP+P I W                        DG  +  SH
Sbjct: 3035 SYLVEPVGGSIQLDCVVRGDPVPDIHW----------------------IKDGLPLRGSH 3072

Query: 375  ARVS----SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEG 429
             R      SLT+   +  DAG Y C A N +G   + + L +Q AP  Q  P  +    G
Sbjct: 3073 LRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSG 3132

Query: 430  NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 489
            + V + C+    P+ TI W + GQ L +S     ++   P  S L +      D G Y+C
Sbjct: 3133 DDVALRCQATGEPTPTIEWLQAGQPLRASR----RLRTLPDGS-LWLENVETGDAGTYDC 3187

Query: 490  TAVNRIGQESLEFILVQADTP 510
             A N +G  +    LV    P
Sbjct: 3188 VAHNLLGSATARAFLVVRGEP 3208



 Score =  117 bits (294), Expect = 3e-26
 Identities = 119/495 (24%), Positives = 195/495 (39%), Gaps = 51/495 (10%)

Query: 26   PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
            P++  ++ G     LC   G  +  +I+W   +G+ LT  +        ++S +T  +  
Sbjct: 2311 PTELSLTPGAPMELLCDAQGTPQP-NITWHK-DGQALTRLE--------NNSRATRVL-- 2358

Query: 86   ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144
              + DAG+Y C+     G+ E    V V+    ++    P           V+ C V + 
Sbjct: 2359 -RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 2417

Query: 145  LPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARG-EINFK 202
              P I W   G  ++L++D          +LQ++ +   D G Y C  R  A    + F+
Sbjct: 2418 PAPKITWHRDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2475

Query: 203  DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
               V ++  PTI++    VN + N  Q+  L C A+G P P +SW KD   ++      +
Sbjct: 2476 ---VEIHTVPTIRSGPPAVNVSVN--QTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE 2530

Query: 263  YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELE 322
             +       L I+ V   D   Y+C+A N AG       L+V   P I    +   +   
Sbjct: 2531 IL---PEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2587

Query: 323  EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS--L 380
                L CEASG P P + W              W   +K   LD  +   ++  + S  L
Sbjct: 2588 TPALLPCEASGSPKPLVVW--------------WKDGQK---LDFRLQQGAYRLLPSNAL 2630

Query: 381  TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-WEGNQVNITCEVF 439
             L +    D+ ++ C  SN +G+  +   + V   P +      +T      V +TC   
Sbjct: 2631 LLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHST 2690

Query: 440  AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QE 498
              P+ T+SW + G  L +        Y    +  LE+        G Y C+A N  G   
Sbjct: 2691 GIPAPTVSWSKAGAQLGARGSG----YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 2746

Query: 499  SLEFILVQADTPSSP 513
               F+ VQA     P
Sbjct: 2747 KHVFLTVQASPVVKP 2761



 Score =  115 bits (289), Expect = 1e-25
 Identities = 122/495 (24%), Positives = 186/495 (37%), Gaps = 62/495 (12%)

Query: 41  CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
           C   G  K + ++W      +    Q  ++V+       +L + + +  D+G Y+C  T 
Sbjct: 24  CGTHGTPKPQ-VTWRKGPSSEPLHGQPGVAVL----EEGSLFLASVSPADSGDYECQATN 78

Query: 101 EDGSESE-ATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVI 159
           E GS S  A + V +   +             G+   + CD      P I+W    + V 
Sbjct: 79  EVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVG 138

Query: 160 LKKDVRFIVLSNNYLQIRGIKKTDEGTY----RCE-GRILARGEINFKDIQVIVN----- 209
           +            + Q+ G +  DEG      R + GR   RG       Q         
Sbjct: 139 VPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGL 198

Query: 210 ---------------VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254
                           PP++             G  V L C   G P P + WTKD + +
Sbjct: 199 AGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPV 258

Query: 255 EQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE 314
                       +D   L I      DE  Y C+A + AG+Q     L+V A P I +  
Sbjct: 259 --LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTI-WGS 315

Query: 315 NQT---AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVV 371
           N+T   A+  +  V L CEA G P P+ITW      + +  K  +TR  +Q         
Sbjct: 316 NETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQ--------- 366

Query: 372 RSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG----PVAVYTW 427
                   L L   Q +DAG Y C ASN +G   ++  L+V   P ++G    P  V   
Sbjct: 367 --------LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAV 418

Query: 428 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 487
            G  V + C    +PS T+SW  +G  +  SN S ++       S L +    E   G Y
Sbjct: 419 AGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLE----TDGSVLRLESPGEASSGLY 474

Query: 488 NCTAVNRIGQESLEF 502
           +C A +  G+  L++
Sbjct: 475 SCVASSPAGEAVLQY 489



 Score =  108 bits (271), Expect = 2e-23
 Identities = 113/487 (23%), Positives = 189/487 (38%), Gaps = 40/487 (8%)

Query: 29  GEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNA 86
           GE++V E      LC+  G     +I+WF      L P   ++           L +  A
Sbjct: 319 GEVAVMEDHLVQLLCEARG-VPTPNITWFKDGA--LLPTSTKVVYT---RGGRQLQLGRA 372

Query: 87  NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA---PTPQEFREGEDAVIVCDVVS 143
              DAG+Y C  +   G+  +AT  + ++     + A   P   +   G    + C    
Sbjct: 373 QSSDAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 431

Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
              PT+ W H+G  V    + R +    + L++    +   G Y C     A GE   + 
Sbjct: 432 HPSPTLSWHHEGLPVAESNESR-LETDGSVLRLESPGEASSGLYSCVASSPA-GEAVLQ- 488

Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
             V V VPP +   + +   T  +GQ + L C A G P PT+ W ++G   E+    +  
Sbjct: 489 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQ-- 546

Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVE-NQTAME 320
             +   + L I  V+ +    + C A N+AG   A + + V  +  P +  V   Q    
Sbjct: 547 -VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWG 605

Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKAS----WTRPEKQETLDGHMVVRSHAR 376
            E   +    A+ DP     W    +    E   S    W  P          +  +++ 
Sbjct: 606 XEHHSSF--PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTG--------IPVAYSL 655

Query: 377 VSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNIT 435
              L ++ +   D G Y C A+N  G+  + + L+V   P ++ GPV     E   V + 
Sbjct: 656 PPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLE 715

Query: 436 CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 495
           C     P   +SWF+  Q  P S++  + +  +     L +     +D G+Y C A N  
Sbjct: 716 CLASGVPPPDVSWFKGHQ--PVSSWMGVTV--SVDGRVLRIEQAQLSDAGSYRCVASNVA 771

Query: 496 GQESLEF 502
           G   L +
Sbjct: 772 GSTELRY 778



 Score =  105 bits (263), Expect = 1e-22
 Identities = 93/379 (24%), Positives = 145/379 (38%), Gaps = 38/379 (10%)

Query: 132 GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEG 191
           G D  + C       P + W    + V+       +      L+I G    DEG Y+C  
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA 291

Query: 192 RILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDG 251
              A  +   +D Q+ V+ PPTI                V L+C+A G P P ++W KDG
Sbjct: 292 FSPAGQQA--RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG 349

Query: 252 EQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI- 310
             +       K +++    QL + +   +D   Y C A N  G  +    L V+  P I 
Sbjct: 350 ALL---PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIE 406

Query: 311 -----TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETL 365
                 YV    A      V L C A G P P+++W      ++          E +   
Sbjct: 407 GAGGRPYVVKAVA---GRPVALECVARGHPSPTLSWHHEGLPVAESN-------ESRLET 456

Query: 366 DGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPV 422
           DG          S L L+S     +G Y C AS+  G+      +EVQ  P+L   +G  
Sbjct: 457 DG----------SVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLG 506

Query: 423 AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEN 482
            V T  G  + + C+    P  TI W ++G+  P+   + +++      + L +     +
Sbjct: 507 QVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEELAGVQV--ASQGTTLHIDHVELD 562

Query: 483 DFGNYNCTAVNRIGQESLE 501
             G + C A N  G    E
Sbjct: 563 HSGLFACQATNEAGTAGAE 581



 Score =  103 bits (257), Expect = 7e-22
 Identities = 92/389 (23%), Positives = 160/389 (41%), Gaps = 45/389 (11%)

Query: 34   GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
            G   F  C+  G + + +I+W   +G+ ++  + + ++      S  L + N    DAG 
Sbjct: 2861 GSHAFLPCKARG-SPEPNITW-DKDGQPVSGAEGKFTI----QPSGELLVKNLEGQDAGT 2914

Query: 94   YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
            Y C      G  +   V++ I    +F   P  +  R G+   + C    S  P I W  
Sbjct: 2915 YTCTAENAVG-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 2973

Query: 154  KGRDV---ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC--EGRILARGEINFKDIQVIV 208
              R V   + ++D        + LQ   + + D GTY C  E R+     ++F    V V
Sbjct: 2974 NDRPVTEGVSEQD------GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF----VHV 3023

Query: 209  NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
               P +Q  +        +G S+ L C   G P P + W KDG  +       +      
Sbjct: 3024 KEAPVLQG-EAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQL----Q 3078

Query: 269  SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
            +  LTI + +++D   Y C+AEN+ G     + L + + P          +   + V L 
Sbjct: 3079 NGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 3138

Query: 329  CEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYT 388
            C+A+G+P P+I W  + + + +  +   T P+                  SL L++++  
Sbjct: 3139 CQATGEPTPTIEWLQAGQPLRASRRLR-TLPD-----------------GSLWLENVETG 3180

Query: 389  DAGEYICTASNTIGQDSQSMYLEVQYAPK 417
            DAG Y C A N +G  +   +L V+  P+
Sbjct: 3181 DAGTYDCVAHNLLGSATARAFLVVRGEPQ 3209



 Score =  100 bits (250), Expect = 4e-21
 Identities = 106/451 (23%), Positives = 182/451 (40%), Gaps = 52/451 (11%)

Query: 76  DSSSTLTIYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGED 134
           +    L I  +++ D G Y+CV     G ++ +  + V     +   N        E   
Sbjct: 269 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHL 328

Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFI-VLSNNYLQIRGIKKTDEGTYRCE-GR 192
             ++C+      P I W   G   +L    + +       LQ+   + +D G Y C+   
Sbjct: 329 VQLLCEARGVPTPNITWFKDG--ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASN 386

Query: 193 ILARGEINFKDIQVIVNVPPTIQ---ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK 249
            +   E   K  ++ V VPPTI+    R  +V A A  G+ V L C A G P PT+SW  
Sbjct: 387 AVGAAE---KATRLDVYVPPTIEGAGGRPYVVKAVA--GRPVALECVARGHPSPTLSWHH 441

Query: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309
           +G  + +  +        D S L ++   +     Y C+A + AGE      ++V   P+
Sbjct: 442 EGLPVAESNESR---LETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQ 498

Query: 310 ITYVE--NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDG 367
           +   E   Q    + + + L C+ASG P+P+I W  + R   +EE A             
Sbjct: 499 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEELAG------------ 544

Query: 368 HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV--QYAP-KLQGPVAV 424
              V+  ++ ++L +  ++   +G + C A+N  G     + + V  ++AP  L+ P+  
Sbjct: 545 ---VQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQ 601

Query: 425 YTWEGNQVNITCEVFAYPSATISW-------FRDGQLLPSSNY---SNIKI-YNTPSASY 473
           Y W G + + +      P     W         +G   P S +   + I + Y+ P    
Sbjct: 602 YHW-GXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPP-- 658

Query: 474 LEVTPDSENDFGNYNCTAVNRIGQESLEFIL 504
           L++      D G Y C A N  G+   E  L
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVAL 689



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 65/292 (22%), Positives = 102/292 (34%), Gaps = 33/292 (11%)

Query: 235 CDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG 294
           C   G P+P ++W K G   E           ++ S L +  V   D  +Y C A N+ G
Sbjct: 24  CGTHGTPKPQVTWRK-GPSSEPLHGQPGVAVLEEGS-LFLASVSPADSGDYECQATNEVG 81

Query: 295 EQDATIHLKVFAKPKITYVENQTAME--LEEQVTLTCEASGDPIPSITWRTSTRNISSE- 351
                  L V+  P I     +  +     + +TL C+A+G P+P I W    + +    
Sbjct: 82  STSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPL 141

Query: 352 --EKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT--------- 400
                 W     Q  + GH ++       SL    IQ   +G     A  +         
Sbjct: 142 GWAGYGWDLGWGQ--VGGHRLLDEG---QSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXA 196

Query: 401 ----IGQDSQSMYLEVQYAPKLQGPVA---VYTWEGNQVNITCEVFAYPSATISWFRDGQ 453
                 Q            P + G  A   V    G  V + C     P+  + W +D Q
Sbjct: 197 GLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQ 256

Query: 454 -LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 504
            +LP   +  ++         L +T     D G Y C A +  GQ++ +F L
Sbjct: 257 PVLPGGPHLQVQ----EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQL 304


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  148 bits (374), Expect = 2e-35
 Identities = 120/451 (26%), Positives = 185/451 (41%), Gaps = 40/451 (8%)

Query: 78   SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137
            S  L I  A    AG Y C      G  +   V + +    + K  P+       E+ ++
Sbjct: 3909 SGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 3967

Query: 138  VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
             C+      PTI W+ +G +V      +  VL    L+I      D G Y C  +  A  
Sbjct: 3968 PCEASGIPRPTITWQKEGLNVATGVSTQ--VLPGGQLRIAHASPEDAGNYLCIAKNSAGS 4025

Query: 198  EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
             +     +++V VPP I+    + + +   G    L C A G PEP ++W KDG+ +   
Sbjct: 4026 AMG--KTRLVVQVPPVIE--NGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA 4081

Query: 258  EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
            E   K+     S +L +K ++  D   Y C AEN  G     +HL +   P  T +    
Sbjct: 4082 EG--KFTIQP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR 4138

Query: 318  AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARV 377
            ++ L +++ L C A G P P I W  + R ++          E     DG          
Sbjct: 4139 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT----------EGVSEQDGG--------- 4179

Query: 378  SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVNIT 435
            S+L   ++   D+G Y+C A N +G+     ++ V+ AP LQG    Y  E  G  + + 
Sbjct: 4180 STLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLD 4239

Query: 436  CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 495
            C V   P   I W +DG  L  S+  + ++ N      L +     +D G Y C A N +
Sbjct: 4240 CVVRGDPVPDIHWIKDGLPLRGSHLRH-QLQN----GSLTIHRTERDDAGRYQCLAENEM 4294

Query: 496  GQESLEFILVQADTPSSPSIDQVEPYSSTAQ 526
            G      ILV    P    + QVEP   T +
Sbjct: 4295 GVAKKVVILVLQSAP----VFQVEPQDMTVR 4321



 Score =  144 bits (364), Expect = 3e-34
 Identities = 132/489 (26%), Positives = 204/489 (41%), Gaps = 47/489 (9%)

Query: 31   ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
            + VG+     C+      +  ++W+  +G+ L   Q+  ++         L I  A + D
Sbjct: 3044 VRVGDKAVLSCETDA-LPEPTVTWYK-DGQPLVLAQRTQAL----RGGQRLEIQEAQVSD 3097

Query: 91   AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR-EGEDAVIVCDVVSSLPPTI 149
             G+Y C V+   G E+  T  + +     F+N  T    +  G   V+ CDV     PT+
Sbjct: 3098 KGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 3156

Query: 150  IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVN 209
             W  K R  +    V  +V     LQ+  ++    GTY C      + E   KD  V V 
Sbjct: 3157 TWL-KDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEAR-KDFVVAVL 3213

Query: 210  VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269
            V P I++           GQ V L C+A+G P P ++W KDG  + Q+       + D  
Sbjct: 3214 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 3273

Query: 270  SQLTIKKVDKNDEAEYICIAENKAGEQDATIH-LKVFAKPKITYVENQTAMELE---EQV 325
            S L +K +  +D   Y C+A N AGE DA +H + V   P I    + +   +    E V
Sbjct: 3274 S-LVLKGLRASDAGAYTCVAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 3331

Query: 326  TLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSI 385
            T+ C   G P   ++W           K     P  Q TL        H    +L +  +
Sbjct: 3332 TMVCPVRGSPPIHVSWL----------KDGLPLPLSQRTL-------LHGSGHTLRISKV 3374

Query: 386  QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA----VYTWEGNQVNITCEVFAY 441
            Q  DAG + C A++  G   ++  L+VQ  P L+ PV     V    G+ V + CE    
Sbjct: 3375 QLADAGIFTCVAASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEARGV 3433

Query: 442  PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 501
            P   +SW +DG+ L S +     +   PS   L++      D G Y+C AV+  G+    
Sbjct: 3434 PLPLVSWMKDGEPLLSQS-----LEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRH 3485

Query: 502  FILVQADTP 510
            F L   + P
Sbjct: 3486 FQLTVMEPP 3494



 Score =  143 bits (360), Expect = 8e-34
 Identities = 128/501 (25%), Positives = 217/501 (43%), Gaps = 68/501 (13%)

Query: 52   ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT---GEDGSESEA 108
            I W+  +G+ +TP+  R+ V+        L I    + D+G Y CV T   GED  +   
Sbjct: 2671 IRWYK-DGQPVTPSS-RLQVL---GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNV 2725

Query: 109  TVNVK-IFQKL-----MFKNAPTPQEFR----------EGEDAVIVCDVVSSLPPTIIWK 152
             + V  +FQK+      F+     +E R          E   A + CD  +  PP + W 
Sbjct: 2726 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 2785

Query: 153  HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI--NFKDIQVIVNV 210
             + + +    +V  ++     LQI  ++  + G Y C+    A  E+  ++   +++V  
Sbjct: 2786 REDQPLSAGDEVS-VLQGGRVLQIPLVRAENAGRYSCK----ASNEVGEDWLHYELLVLT 2840

Query: 211  PPTI--QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
            PP I     + +   T N   +V+L C A G P PT+SW ++G          +    +D
Sbjct: 2841 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSP---RLQVLED 2897

Query: 269  SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-NQTAMELEEQVTL 327
               L +   +  D A Y+C+AEN+AG  +    L+V   P+I  ++  Q    L   V+L
Sbjct: 2898 GQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSL 2957

Query: 328  TCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQY 387
             C+    P P +TW   ++ +S  E+               ++  +H    +L L   + 
Sbjct: 2958 PCDVHAHPNPEVTWYKDSQALSLGEEV-------------FLLPGTH----TLQLGRARL 3000

Query: 388  TDAGEYICTASNTIGQDSQSMYLEVQYAPKL----QGPV-AVYTWEGNQVNITCEVFAYP 442
            +D+G Y C A N  G+D + + L V   P      +GP  AV    G++  ++CE  A P
Sbjct: 3001 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 3060

Query: 443  SATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 502
              T++W++DGQ L  +     +         LE+     +D G Y+C   N  G+    F
Sbjct: 3061 EPTVTWYKDGQPLVLAQ----RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTF 3116

Query: 503  IL-VQA----DTPSSPSIDQV 518
             L VQ     + P + ++ QV
Sbjct: 3117 TLTVQVPPTFENPKTETVSQV 3137



 Score =  142 bits (359), Expect = 1e-33
 Identities = 133/508 (26%), Positives = 205/508 (40%), Gaps = 62/508 (12%)

Query: 12   FFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISV 71
            + LG  V  QV   P   ++ VGE+    C   G+ + + +SW S +G  L     + SV
Sbjct: 1112 YVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQ-LSW-SKDGVVLQGRGPQGSV 1169

Query: 72   VWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQ--EF 129
             +    +S          DAG Y+C  +   G ++   V +++ +   +    T    E 
Sbjct: 1170 HFAAIRTS----------DAGRYRCEASNSAGVDAWE-VELRVLEPPHWGADETSGLLER 1218

Query: 130  REGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC 189
              GE+A + C    +  P + W+       L       VL    L +  +   D G Y C
Sbjct: 1219 VAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYEC 1278

Query: 190  EGRILARGEINF--KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW 247
            +    A  E+    +  +++V VPP+I+      N +   GQS+TL CDA GFP P + W
Sbjct: 1279 Q----ATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVW 1334

Query: 248  TKDGEQIEQEEDDEKYIFS------------DDSSQLTIKKVDKNDEAEYICIAENKAGE 295
             KD + +        Y +             D+   L   ++ + D   Y C AEN+AG 
Sbjct: 1335 LKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGT 1394

Query: 296  QDATIHLKVFAKPKITYV-ENQTAMELE-EQVTLTCEASGDPIPSITWRTSTRNISSEEK 353
                 HL V   P +      Q  + L    V L C  SG P P + W            
Sbjct: 1395 AQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW------------ 1442

Query: 354  ASWTRPEKQETLDG--HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLE 411
                  ++Q  L G  H+ V+   +V  +T   +   D G Y C A +  GQ ++   L 
Sbjct: 1443 ----TKDRQPVLPGGPHLQVQEDGQVLRITGSHV--GDEGRYQCVAFSPAGQQARDFQLR 1496

Query: 412  VQYAPKLQG---PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNT 468
            V   P + G      V   E + V + CE    P+  I+WF+DG LLP+S     K+  T
Sbjct: 1497 VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST----KVVYT 1552

Query: 469  PSASYLEVTPDSENDFGNYNCTAVNRIG 496
                 L++     +D G Y C A N +G
Sbjct: 1553 RGGRQLQLGRAQSSDAGVYTCKASNAVG 1580



 Score =  138 bits (347), Expect = 2e-32
 Identities = 138/498 (27%), Positives = 200/498 (40%), Gaps = 59/498 (11%)

Query: 21   QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSST 80
            QV I  S    S G      C  +G      ISW   +  +      RI V    D+  T
Sbjct: 609  QVSIHTSSQHFSQGVEVKVSCSASG-YPTPHISWSRES--QALQEDSRIHV----DAQGT 661

Query: 81   LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE------GED 134
            L I     +DAG Y C  T E G++ E          L + + P+            GE+
Sbjct: 662  LIIQGVAPEDAGNYSCQATNEVGTDQETVT-------LYYTDPPSVSAVNAVVLVAVGEE 714

Query: 135  AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRIL 194
            AV+VC+     PP +IW   G ++IL  +      S+  L+I   ++ D GTY C     
Sbjct: 715  AVLVCEASGVPPPRVIWYRGGLEMILAPEGS----SSGKLRIPAAQERDAGTYTCR---- 766

Query: 195  ARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK-DGEQ 253
            A  E+     ++ + V    Q  +   + T  LG+S  L C A G P PT++W + DG+ 
Sbjct: 767  AVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQP 826

Query: 254  IEQEEDDEKYIFS--DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKV--FAKPK 309
            +       +   S   DS  L  + V   D+A Y+C A N  G+  A   L V   A P+
Sbjct: 827  LGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQ 886

Query: 310  ITYVENQTAMELEEQVTLTCEA-SGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGH 368
            I        +   + V+L C   +G P+P   W    R +    + S             
Sbjct: 887  IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHS------------- 933

Query: 369  MVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVY--T 426
              +R+     SL L       AG Y C A+NT G   + + L VQ  P++  P A +  T
Sbjct: 934  --IRADG---SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIH-PTATHHIT 987

Query: 427  WEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN 486
             EG   ++ C     P+ TI+W ++   L S        YN      L +   S  D G 
Sbjct: 988  NEGVPASLPCVASGVPAPTITWTKETNALTSRGPH----YNVSKEGTLLIAQPSAQDAGA 1043

Query: 487  YNCTAVNRIGQESLEFIL 504
            Y CTA N +G  S E  L
Sbjct: 1044 YVCTATNTVGFSSQEMRL 1061



 Score =  133 bits (334), Expect = 8e-31
 Identities = 116/452 (25%), Positives = 197/452 (43%), Gaps = 43/452 (9%)

Query: 81   LTIYNANIDDAGIYKCVVTGEDGSESE-ATVNVKIFQKLMF-KNAPTPQEFREGEDAVIV 138
            L +  A +   G Y C  +   G+ S+   + V +  ++   +  PT     +   A + 
Sbjct: 2220 LYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 2279

Query: 139  CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA-RG 197
            C+     PPT+ W+  G+ V  +  ++ +      L +   +    G Y C    LA R 
Sbjct: 2280 CNATGKPPPTVTWERDGQPVGAELGLQ-LQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 2338

Query: 198  EINFKDIQVIVNVPPTIQARQN-IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
            E  F   ++ V VPP +    + + N TA L   +TL+C+A G P P + W +  E +  
Sbjct: 2339 ERKF---ELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP 2395

Query: 257  EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
             ED   Y+ +     L + +  + D   Y C+A N+AGE      ++V   P I   + +
Sbjct: 2396 GED--TYLLA-GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLE 2452

Query: 317  TAMELEEQVT--LTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSH 374
              +++ +  T  L C  +G P P +TW    R ++  + A    P      DG ++    
Sbjct: 2453 EVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD-AHHISP------DGVLLQVLQ 2505

Query: 375  ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPV------AVYTWE 428
            A +SS          AG Y C A+N +G+ ++   L V  AP + G         V    
Sbjct: 2506 ANLSS----------AGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTV 2555

Query: 429  GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
             N +++ CE  A+PS  I+W +DG    +S   NI++   P    L++    + D G Y 
Sbjct: 2556 NNPISLICEALAFPSPNITWMKDGAPFEASR--NIQL--LPGTHGLQILNAQKEDAGQYT 2611

Query: 489  CTAVNRIGQESLEFILVQADTPSSPSIDQVEP 520
            C   N +G E+++   V+   P  PSI + +P
Sbjct: 2612 CVVTNELG-EAVKNYHVEVLIP--PSISKDDP 2640



 Score =  132 bits (333), Expect = 1e-30
 Identities = 125/491 (25%), Positives = 196/491 (39%), Gaps = 53/491 (10%)

Query: 34   GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
            GE+    C   G  K + ++W      +    Q  ++V+       +L + + +  D+G 
Sbjct: 1221 GENASLPCPARGTPKPQ-VTWRKGPSSEPLHGQPGVAVL----EEGSLFLASVSPADSGD 1275

Query: 94   YKCVVTGEDGSESE-ATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWK 152
            Y+C  T E GS S  A + V +   +             G+   + CD      P I+W 
Sbjct: 1276 YECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWL 1335

Query: 153  HKGRDVILKK-------DVRFIVLSNNYLQIRG-------IKKTDEGTYRCEGRILARGE 198
               + V +         D+ +  +  + L   G       I++ D G Y C     A G 
Sbjct: 1336 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQA-GT 1394

Query: 199  INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
               +D  ++V  PP++             G  V L C   G P P + WTKD + +    
Sbjct: 1395 AQ-RDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGG 1453

Query: 259  DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT- 317
               +    +D   L I      DE  Y C+A + AG+Q     L+V A P I +  N+T 
Sbjct: 1454 PHLQV--QEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTI-WGSNETG 1510

Query: 318  --AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHA 375
              A+  +  V L CEA G P P+ITW      + +  K  +TR  +Q             
Sbjct: 1511 EVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQ------------- 1557

Query: 376  RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG----PVAVYTWEGNQ 431
                L L   Q +DAG Y C ASN +G   ++  L+V   P ++G    P  V    G  
Sbjct: 1558 ----LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRP 1613

Query: 432  VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 491
            V + C    +PS T+SW  +G  +  SN S ++       S L +    E   G Y+C A
Sbjct: 1614 VALECVARGHPSPTLSWHHEGLPVAESNESRLE----TDGSVLRLESPGEASSGLYSCVA 1669

Query: 492  VNRIGQESLEF 502
             +  G+  L++
Sbjct: 1670 SSPAGEAVLQY 1680



 Score =  129 bits (323), Expect = 2e-29
 Identities = 117/482 (24%), Positives = 199/482 (41%), Gaps = 45/482 (9%)

Query: 31  ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
           +S GE+    C+V G+A   +++W   +   L  +  R++ +    +  +L I      D
Sbjct: 528 VSPGETAVLSCRVLGEAP-YNLTWVR-DWRVLPASTGRVAQL----ADLSLEISGIIPTD 581

Query: 91  AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
            G Y+CV +  +G  + A+V + + +        + Q F +G +  + C       P I 
Sbjct: 582 GGRYQCVASNANGV-TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHIS 640

Query: 151 WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINF--KDIQVIV 208
           W  + +   L++D R  V +   L I+G+   D G Y C+    A  E+    + + +  
Sbjct: 641 WSRESQ--ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ----ATNEVGTDQETVTLYY 694

Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDG-EQIEQEEDDEKYIFSD 267
             PP++ A   +V     +G+   LVC+A G P P + W + G E I   E         
Sbjct: 695 TDPPSVSAVNAVVLVA--VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-------GS 745

Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327
            S +L I    + D   Y C A N+ G+  A I L V   P++T +     +EL     L
Sbjct: 746 SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALL 805

Query: 328 TCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQY 387
            C A+G P P++TWR            +      ++   G            L  +S+  
Sbjct: 806 ACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG-----------VLFFESVAP 854

Query: 388 TDAGEYICTASNTIGQ-DSQSMYLEVQYAPK--LQGPVAVYTWEGNQVNITCEVFA-YPS 443
            D   Y+C A N  G+  +++  +   +AP         V   EG  V++ C V A  P 
Sbjct: 855 EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 914

Query: 444 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 503
               W +DG+ LP  +  +I+     +   L +    +   G Y+C A N  G +  +  
Sbjct: 915 PERHWLKDGRPLPPGSRHSIR-----ADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVE 969

Query: 504 LV 505
           LV
Sbjct: 970 LV 971



 Score =  128 bits (322), Expect = 2e-29
 Identities = 123/483 (25%), Positives = 187/483 (38%), Gaps = 38/483 (7%)

Query: 81   LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
            L I   ++ D GIY C  T   G ES+  V +K+      +  P  +   E     + C 
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 1908

Query: 141  VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC-EGRILARGEI 199
                 PP + W  KG   +       + +    L+I   + +D G+YRC    +    E+
Sbjct: 1909 ASGVPPPDVSW-FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 1967

Query: 200  NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
             +    + VNVPP I    ++      +   V L C+A G P PT+ W KDG  +     
Sbjct: 1968 RYG---LRVNVPPRITLPPSLPGPVL-VNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGT 2023

Query: 260  DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
                +F      LT+     +D   Y C+A +  GE    + L+V   P I   E   ++
Sbjct: 2024 PGLQVFPG-GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSV 2082

Query: 320  ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS 379
               E V L C++   P P ++W              W      E   G   V   A  + 
Sbjct: 2083 VANESVALECQSHAMPPPVLSW--------------WKDGRPLEPRPG---VHLSADKAL 2125

Query: 380  LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP--KLQGPVAVYTWEGNQVNITCE 437
            L +      DAG Y C A N  G   +   L V  AP   L+    +   EG+  +++CE
Sbjct: 2126 LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCE 2185

Query: 438  VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 497
                P   ISW +DGQ LP        +       YL     ++   G Y C   N +G 
Sbjct: 2186 CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE--GTYTCECSNVVGN 2243

Query: 498  ESLEFILVQADTPSSPSI-DQVEPYSSTAQVQFD----EPEATG-GVPILKYKAEWRAVG 551
             S +   +Q +    P I    EP +  + VQ      E  ATG   P + ++ + + VG
Sbjct: 2244 SSQD---LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVG 2300

Query: 552  EEV 554
             E+
Sbjct: 2301 AEL 2303



 Score =  127 bits (320), Expect = 3e-29
 Identities = 124/478 (25%), Positives = 195/478 (40%), Gaps = 66/478 (13%)

Query: 34   GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
            GE    +C V G +    +SW   +G  L  +Q+ +       S  TL I    + DAGI
Sbjct: 3328 GELVTMVCPVRG-SPPIHVSWLK-DGLPLPLSQRTLL----HGSGHTLRISKVQLADAGI 3381

Query: 94   YKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP------ 146
            + CV     G ++   T+ V++   L       P EF+   D V+V   +  LP      
Sbjct: 3382 FTCVAASPAGVADRNFTLQVQVPPVL------EPVEFQN--DVVVVRGSLVELPCEARGV 3433

Query: 147  --PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204
              P + W   G  ++ +      +     LQ+  +   D GTY C   +   GE   +  
Sbjct: 3434 PLPLVSWMKDGEPLLSQS-----LEQGPSLQLEAVGAGDSGTYSCVA-VSEAGEAR-RHF 3486

Query: 205  QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264
            Q+ V  PP I+        +   G  + L+CDA+G P+P ++W KDG+ + + E++ +  
Sbjct: 3487 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSR-- 3544

Query: 265  FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--LE 322
                      + +   D   Y C+AE+ AG  + +  ++V A P I        +     
Sbjct: 3545 --------ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP 3596

Query: 323  EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTL 382
             Q+ L C    +P P ITW      I  +E A    PE               R   L L
Sbjct: 3597 GQLVLECSVEAEPAPKITWHRD--GIVLQEDAHTQFPE---------------RGRFLQL 3639

Query: 383  KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAY 441
            +++   D+G+Y CTA N  G  S +  +E+   P ++ GP AV         + C+    
Sbjct: 3640 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 3699

Query: 442  PSATISWFRDG-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 498
            P+  +SW +D   L P S    I     P  S L + P    D G+Y C A N  G +
Sbjct: 3700 PAPLVSWRKDRVPLDPRSPRFEI----LPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 3752



 Score =  127 bits (319), Expect = 4e-29
 Identities = 106/456 (23%), Positives = 186/456 (40%), Gaps = 65/456 (14%)

Query: 90   DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPP 147
            D+G+Y C+ + E G E+    +V++      +N    +  +  +G+ A ++C+V     P
Sbjct: 2417 DSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP 2475

Query: 148  TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
             + W   GR  + + D   I      LQ+     +  G Y C     A GE   K  Q+ 
Sbjct: 2476 KLTWFKDGRP-LARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN-AVGE-KTKHFQLS 2532

Query: 208  VNVPPTI-----QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
            V + PTI      +    V  T N    ++L+C+A  FP P ++W KDG   E   + + 
Sbjct: 2533 VLLAPTILGGAEDSADEEVTVTVN--NPISLICEALAFPSPNITWMKDGAPFEASRNIQ- 2589

Query: 263  YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-------N 315
                  +  L I    K D  +Y C+  N+ GE     H++V   P I+  +        
Sbjct: 2590 --LLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVK 2647

Query: 316  QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHA 375
            +   ++   +TL CE+   P P+I W    + ++   +               + V    
Sbjct: 2648 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSR---------------LQVLGEG 2692

Query: 376  RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ---------------- 419
            R+  L ++  Q +D+G Y+C A+N  G+D Q   + +Q  P  Q                
Sbjct: 2693 RL--LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREE 2750

Query: 420  ---GPVAVY--TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYL 474
               G V  Y    E N   + C+  A P   ++W+R+ Q L + +  ++          L
Sbjct: 2751 EARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV----LQGGRVL 2806

Query: 475  EVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 510
            ++      + G Y+C A N +G++ L + L+    P
Sbjct: 2807 QIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPP 2842



 Score =  125 bits (314), Expect = 2e-28
 Identities = 114/441 (25%), Positives = 171/441 (38%), Gaps = 54/441 (12%)

Query: 81   LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
            L I +A+ +DAG Y C+     GS    T  + +    + +N        EG  A + C 
Sbjct: 4002 LRIAHASPEDAGNYLCIAKNSAGSAMGKT-RLVVQVPPVIENGLPDLSTTEGSHAFLPCK 4060

Query: 141  VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195
               S  P I W   G+ V    + +F +  +  L ++ ++  D GTY C      GR   
Sbjct: 4061 ARGSPEPNITWDKDGQPVS-GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR 4119

Query: 196  RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
            R  +    + V   +P     R         LG  + L C A G P P + WT +   + 
Sbjct: 4120 RVHLTILVLPVFTTLPGDRSLR---------LGDRLWLRCAARGSPTPRIGWTVNDRPVT 4170

Query: 256  QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
            +   ++     D  S L    V + D   Y+C AEN+ G   A   + V   P +     
Sbjct: 4171 EGVSEQ-----DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAF 4225

Query: 316  QTAME-LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSH 374
               +E +   + L C   GDP+P I W                        DG  +  SH
Sbjct: 4226 SYLVEPVGGSIQLDCVVRGDPVPDIHW----------------------IKDGLPLRGSH 4263

Query: 375  ARVS----SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEG 429
             R      SLT+   +  DAG Y C A N +G   + + L +Q AP  Q  P  +    G
Sbjct: 4264 LRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSG 4323

Query: 430  NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 489
            + V + C+    P+ TI W + GQ L +S     ++   P  S L +      D G Y+C
Sbjct: 4324 DDVALRCQATGEPTPTIEWLQAGQPLRASR----RLRTLPDGS-LWLENVETGDAGTYDC 4378

Query: 490  TAVNRIGQESLEFILVQADTP 510
             A N +G  +    LV    P
Sbjct: 4379 VAHNLLGSATARAFLVVRGEP 4399



 Score =  117 bits (294), Expect = 3e-26
 Identities = 119/495 (24%), Positives = 195/495 (39%), Gaps = 51/495 (10%)

Query: 26   PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
            P++  ++ G     LC   G  +  +I+W   +G+ LT  +        ++S +T  +  
Sbjct: 3502 PTELSLTPGAPMELLCDAQGTPQP-NITWHK-DGQALTRLE--------NNSRATRVL-- 3549

Query: 86   ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144
              + DAG+Y C+     G+ E    V V+    ++    P           V+ C V + 
Sbjct: 3550 -RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 3608

Query: 145  LPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARG-EINFK 202
              P I W   G  ++L++D          +LQ++ +   D G Y C  R  A    + F+
Sbjct: 3609 PAPKITWHRDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 3666

Query: 203  DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
               V ++  PTI++    VN + N  Q+  L C A+G P P +SW KD   ++      +
Sbjct: 3667 ---VEIHTVPTIRSGPPAVNVSVN--QTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE 3721

Query: 263  YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELE 322
             +       L I+ V   D   Y+C+A N AG       L+V   P I    +   +   
Sbjct: 3722 IL---PEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 3778

Query: 323  EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS--L 380
                L CEASG P P + W              W   +K   LD  +   ++  + S  L
Sbjct: 3779 TPALLPCEASGSPKPLVVW--------------WKDGQK---LDFRLQQGAYRLLPSNAL 3821

Query: 381  TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-WEGNQVNITCEVF 439
             L +    D+ ++ C  SN +G+  +   + V   P +      +T      V +TC   
Sbjct: 3822 LLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHST 3881

Query: 440  AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QE 498
              P+ T+SW + G  L +        Y    +  LE+        G Y C+A N  G   
Sbjct: 3882 GIPAPTVSWSKAGAQLGARGSG----YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 3937

Query: 499  SLEFILVQADTPSSP 513
               F+ VQA     P
Sbjct: 3938 KHVFLTVQASPVVKP 3952



 Score =  110 bits (275), Expect = 6e-24
 Identities = 117/481 (24%), Positives = 180/481 (37%), Gaps = 82/481 (17%)

Query: 31   ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
            ++VGE    +C+ +G    + I W+    E +   +          SS  L I  A   D
Sbjct: 709  VAVGEEAVLVCEASGVPPPRVI-WYRGGLEMILAPE--------GSSSGKLRIPAAQERD 759

Query: 91   AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
            AG Y C    E G  S A + + +         P       G  A++ C      PPT+ 
Sbjct: 760  AGTYTCRAVNELGDAS-AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVT 818

Query: 151  WKH-KGRDVILK----KDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQ 205
            W+   G+ + L+    +  R     +  L    +   D+  Y CE R +  G++  +   
Sbjct: 819  WRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF-GKVQAEARL 877

Query: 206  VIV-NVPPTIQARQNIVNATANLGQSVTLVCDA-EGFPEPTMSWTKDGEQIEQEEDDEKY 263
            ++  + PP I +    V      GQ V+L C    G P P   W KDG  +       ++
Sbjct: 878  IVTGHAPPQIASSAPTVRVLE--GQPVSLPCIVLAGRPLPERHWLKDGRPLPP---GSRH 932

Query: 264  IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEE 323
                D S L + +  +     Y C+A N AG Q   + L V   P+I             
Sbjct: 933  SIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGV 991

Query: 324  QVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLK 383
              +L C ASG P P+ITW   T  ++S        P    + +G +++   +        
Sbjct: 992  PASLPCVASGVPAPTITWTKETNALTSRG------PHYNVSKEGTLLIAQPSA------- 1038

Query: 384  SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPS 443
                 DAG Y+CTA+NT+G  SQ M L V      +  ++ Y WE               
Sbjct: 1039 ----QDAGAYVCTATNTVGFSSQEMRLSVN-----RLALSKYVWE--------------- 1074

Query: 444  ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 503
                   +  LLPS +              L +      D G+Y CTA N  G  S  ++
Sbjct: 1075 -------EYGLLPSGS--------------LRLAQVQVGDSGHYECTASNPAGSASHRYV 1113

Query: 504  L 504
            L
Sbjct: 1114 L 1114



 Score =  109 bits (272), Expect = 1e-23
 Identities = 112/463 (24%), Positives = 183/463 (39%), Gaps = 34/463 (7%)

Query: 55   FSPNGEKLTPNQQRIS-VVWNDDS---SSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
            FS    +L+ N+  +S  VW +     S +L +    + D+G Y+C  +   GS S   V
Sbjct: 1054 FSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYV 1113

Query: 111  NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
             + +      +  P   +   GE   + C    +  P + W   G  V+L+         
Sbjct: 1114 -LGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDG--VVLQGRG-----P 1165

Query: 171  NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQS 230
               +    I+ +D G YRCE    A   ++  ++++ V  PP   A +         G++
Sbjct: 1166 QGSVHFAAIRTSDAGRYRCEASNSA--GVDAWEVELRVLEPPHWGADETSGLLERVAGEN 1223

Query: 231  VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAE 290
             +L C A G P+P ++W K G   E           ++ S L +  V   D  +Y C A 
Sbjct: 1224 ASLPCPARGTPKPQVTWRK-GPSSEPLHGQPGVAVLEEGS-LFLASVSPADSGDYECQAT 1281

Query: 291  NKAGEQDATIHLKVFAKPKITYVENQTAME--LEEQVTLTCEASGDPIPSITWRTSTRNI 348
            N+ G       L V+  P I     +  +     + +TL C+A+G P+P I W    + +
Sbjct: 1282 NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 1341

Query: 349  S---SEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDS 405
                      W     Q  + GH ++       SL    IQ  D+G Y C A N  G   
Sbjct: 1342 GVPLGWAGYGWDLGWGQ--VGGHRLLDEG---QSLHFPRIQEGDSGLYSCRAENQAGTAQ 1396

Query: 406  QSMYLEVQYAPKLQGPVA---VYTWEGNQVNITCEVFAYPSATISWFRDGQ-LLPSSNYS 461
            +  +L V   P + G  A   V    G  V + C     P+  + W +D Q +LP   + 
Sbjct: 1397 RDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHL 1456

Query: 462  NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 504
             ++         L +T     D G Y C A +  GQ++ +F L
Sbjct: 1457 QVQ----EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQL 1495



 Score =  108 bits (271), Expect = 2e-23
 Identities = 113/487 (23%), Positives = 189/487 (38%), Gaps = 40/487 (8%)

Query: 29   GEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNA 86
            GE++V E      LC+  G     +I+WF      L P   ++           L +  A
Sbjct: 1510 GEVAVMEDHLVQLLCEARG-VPTPNITWFKDGA--LLPTSTKVVYT---RGGRQLQLGRA 1563

Query: 87   NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA---PTPQEFREGEDAVIVCDVVS 143
               DAG+Y C  +   G+  +AT  + ++     + A   P   +   G    + C    
Sbjct: 1564 QSSDAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 1622

Query: 144  SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
               PT+ W H+G  V    + R +    + L++    +   G Y C     A GE   + 
Sbjct: 1623 HPSPTLSWHHEGLPVAESNESR-LETDGSVLRLESPGEASSGLYSCVASSPA-GEAVLQ- 1679

Query: 204  IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
              V V VPP +   + +   T  +GQ + L C A G P PT+ W ++G   E+    +  
Sbjct: 1680 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQ-- 1737

Query: 264  IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVE-NQTAME 320
              +   + L I  V+ +    + C A N+AG   A + + V  +  P +  V   Q    
Sbjct: 1738 -VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWG 1796

Query: 321  LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKAS----WTRPEKQETLDGHMVVRSHAR 376
             E   +    A+ DP     W    +    E   S    W  P          +  +++ 
Sbjct: 1797 XEHHSSF--PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTG--------IPVAYSL 1846

Query: 377  VSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNIT 435
               L ++ +   D G Y C A+N  G+  + + L+V   P ++ GPV     E   V + 
Sbjct: 1847 PPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLE 1906

Query: 436  CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 495
            C     P   +SWF+  Q  P S++  + +  +     L +     +D G+Y C A N  
Sbjct: 1907 CLASGVPPPDVSWFKGHQ--PVSSWMGVTV--SVDGRVLRIEQAQLSDAGSYRCVASNVA 1962

Query: 496  GQESLEF 502
            G   L +
Sbjct: 1963 GSTELRY 1969



 Score =  105 bits (263), Expect = 1e-22
 Identities = 125/533 (23%), Positives = 189/533 (35%), Gaps = 102/533 (19%)

Query: 77   SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEF--REGED 134
            +  +L +  A  + AG Y CV T   GS+     +V++  ++  +  PT       EG  
Sbjct: 936  ADGSLHLDRALQEHAGRYSCVATNTAGSQHR---DVELVVQVPPRIHPTATHHITNEGVP 992

Query: 135  AVIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC---- 189
            A + C V S +P PTI W  K  + +  +   + V     L I      D G Y C    
Sbjct: 993  ASLPC-VASGVPAPTITWT-KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATN 1050

Query: 190  ------------------------EGRILARGEINFKDIQVI------------------ 207
                                    E  +L  G +    +QV                   
Sbjct: 1051 TVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASH 1110

Query: 208  -----VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
                 V VPP +Q    ++     +G+++ L C AEG PEP +SW+KDG  ++       
Sbjct: 1111 RYVLGVQVPPQVQPGPRVLKVL--VGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGS 1168

Query: 263  YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME-- 320
              F+          +  +D   Y C A N AG     + L+V   P     E    +E  
Sbjct: 1169 VHFA---------AIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERV 1219

Query: 321  LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSL 380
              E  +L C A G P P +TWR               +    E L G   V +     SL
Sbjct: 1220 AGENASLPCPARGTPKPQVTWR---------------KGPSSEPLHGQPGV-AVLEEGSL 1263

Query: 381  TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGP---VAVYTWEGNQVNITCE 437
             L S+   D+G+Y C A+N +G  S+   L V   P ++       V    G  + + C+
Sbjct: 1264 FLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECD 1323

Query: 438  VFAYPSATISWFRDGQLLP----------SSNYSNIKIYNT-PSASYLEVTPDSENDFGN 486
               +P   I W +D QL+              +  +  +        L      E D G 
Sbjct: 1324 ANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGL 1383

Query: 487  YNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVP 539
            Y+C A N+ G    +F L+    PS       +     A    +    T GVP
Sbjct: 1384 YSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVP 1436



 Score =  103 bits (257), Expect = 7e-22
 Identities = 87/376 (23%), Positives = 149/376 (39%), Gaps = 35/376 (9%)

Query: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA 195
           ++ C V S+LP  +  + +  +  L ++  F    N+  +I    K +EGTY C   +  
Sbjct: 445 LVSCSVHSALPFRL--QLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTA-VSR 501

Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
            G    K   V+ + PP +    N+   T + G++  L C   G     ++W +D   + 
Sbjct: 502 AGTGRAKAQIVVTDPPPQLVPAPNV---TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLP 558

Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
                   +       L I  +   D   Y C+A N  G   A++ L V   P+++   +
Sbjct: 559 ASTGRVAQLAD---LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTS 615

Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHA 375
                   +V ++C ASG P P I+W   ++ +  + +              H+  +   
Sbjct: 616 SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI-------------HVDAQG-- 660

Query: 376 RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNI 434
              +L ++ +   DAG Y C A+N +G D +++ L     P +    AV     G +  +
Sbjct: 661 ---TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 717

Query: 435 TCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNR 494
            CE    P   + W+R G  +       I      S+  L +    E D G Y C AVN 
Sbjct: 718 VCEASGVPPPRVIWYRGGLEM-------ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNE 770

Query: 495 IGQESLEFILVQADTP 510
           +G  S E  L     P
Sbjct: 771 LGDASAEIQLAVGHAP 786



 Score =  103 bits (257), Expect = 7e-22
 Identities = 92/389 (23%), Positives = 160/389 (41%), Gaps = 45/389 (11%)

Query: 34   GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
            G   F  C+  G + + +I+W   +G+ ++  + + ++      S  L + N    DAG 
Sbjct: 4052 GSHAFLPCKARG-SPEPNITW-DKDGQPVSGAEGKFTI----QPSGELLVKNLEGQDAGT 4105

Query: 94   YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
            Y C      G  +   V++ I    +F   P  +  R G+   + C    S  P I W  
Sbjct: 4106 YTCTAENAVG-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 4164

Query: 154  KGRDV---ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC--EGRILARGEINFKDIQVIV 208
              R V   + ++D        + LQ   + + D GTY C  E R+     ++F    V V
Sbjct: 4165 NDRPVTEGVSEQD------GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF----VHV 4214

Query: 209  NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
               P +Q  +        +G S+ L C   G P P + W KDG  +       +      
Sbjct: 4215 KEAPVLQG-EAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQL----Q 4269

Query: 269  SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
            +  LTI + +++D   Y C+AEN+ G     + L + + P          +   + V L 
Sbjct: 4270 NGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 4329

Query: 329  CEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYT 388
            C+A+G+P P+I W  + + + +  +   T P+                  SL L++++  
Sbjct: 4330 CQATGEPTPTIEWLQAGQPLRASRRLR-TLPD-----------------GSLWLENVETG 4371

Query: 389  DAGEYICTASNTIGQDSQSMYLEVQYAPK 417
            DAG Y C A N +G  +   +L V+  P+
Sbjct: 4372 DAGTYDCVAHNLLGSATARAFLVVRGEPQ 4400



 Score =  100 bits (250), Expect = 4e-21
 Identities = 106/451 (23%), Positives = 182/451 (40%), Gaps = 52/451 (11%)

Query: 76   DSSSTLTIYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGED 134
            +    L I  +++ D G Y+CV     G ++ +  + V     +   N        E   
Sbjct: 1460 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHL 1519

Query: 135  AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVL-SNNYLQIRGIKKTDEGTYRCEG-R 192
              ++C+      P I W   G   +L    + +       LQ+   + +D G Y C+   
Sbjct: 1520 VQLLCEARGVPTPNITWFKDG--ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASN 1577

Query: 193  ILARGEINFKDIQVIVNVPPTIQA---RQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK 249
             +   E   K  ++ V VPPTI+    R  +V A A  G+ V L C A G P PT+SW  
Sbjct: 1578 AVGAAE---KATRLDVYVPPTIEGAGGRPYVVKAVA--GRPVALECVARGHPSPTLSWHH 1632

Query: 250  DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309
            +G  + +  +        D S L ++   +     Y C+A + AGE      ++V   P+
Sbjct: 1633 EGLPVAESNESR---LETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQ 1689

Query: 310  ITYVEN--QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDG 367
            +   E   Q    + + + L C+ASG P+P+I W  + R   +EE A             
Sbjct: 1690 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEELAG------------ 1735

Query: 368  HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV--QYAP-KLQGPVAV 424
               V+  ++ ++L +  ++   +G + C A+N  G     + + V  ++AP  L+ P+  
Sbjct: 1736 ---VQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQ 1792

Query: 425  YTWEGNQVNITCEVFAYPSATISW-------FRDGQLLPSSNY---SNIKI-YNTPSASY 473
            Y W G + + +      P     W         +G   P S +   + I + Y+ P    
Sbjct: 1793 YHW-GXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPP-- 1849

Query: 474  LEVTPDSENDFGNYNCTAVNRIGQESLEFIL 504
            L++      D G Y C A N  G+   E  L
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVAL 1880



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 69/264 (26%), Positives = 110/264 (41%), Gaps = 31/264 (11%)

Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
           +E++     +S   I +  K +E  Y C A ++AG   A   + V   P          +
Sbjct: 469 EERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV 528

Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS 379
              E   L+C   G+   ++TW    R +     AS  R  +   L             S
Sbjct: 529 SPGETAVLSCRVLGEAPYNLTWVRDWRVL----PASTGRVAQLADL-------------S 571

Query: 380 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-----WEGNQVNI 434
           L +  I  TD G Y C ASN  G    S++L V+ AP+    V+++T      +G +V +
Sbjct: 572 LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ----VSIHTSSQHFSQGVEVKV 627

Query: 435 TCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNR 494
           +C    YP+  ISW R+ Q L   +  ++    T     L +   +  D GNY+C A N 
Sbjct: 628 SCSASGYPTPHISWSRESQALQEDSRIHVDAQGT-----LIIQGVAPEDAGNYSCQATNE 682

Query: 495 IGQESLEFILVQADTPSSPSIDQV 518
           +G +     L   D PS  +++ V
Sbjct: 683 VGTDQETVTLYYTDPPSVSAVNAV 706



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 47/231 (20%), Positives = 81/231 (35%), Gaps = 12/231 (5%)

Query: 378 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITC 436
           SS  +      + G Y CTA +  G       + V   P    P    T   G    ++C
Sbjct: 479 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSC 538

Query: 437 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 496
            V       ++W RD ++LP+S     ++ +      LE++     D G Y C A N  G
Sbjct: 539 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS----LEISGIIPTDGGRYQCVASNANG 594

Query: 497 QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWH 556
                  L+  + P        + +S   +V+     +    P + +  E +A+ E+   
Sbjct: 595 VTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED--- 651

Query: 557 SKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 607
                      +G + I G+ PE        A N  G  + +    +   P
Sbjct: 652 ----SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 698


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  146 bits (369), Expect = 7e-35
 Identities = 130/543 (23%), Positives = 227/543 (41%), Gaps = 51/543 (9%)

Query: 26   PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
            P   +++ G++    C VAG   +    WF    E  + N+ +IS     +  S L I N
Sbjct: 7592 PESIKVTTGDTCTLECTVAG-TPELSTKWFKDGKELTSDNKYKISFF---NKVSGLKIIN 7647

Query: 86   ANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLM---FKNAPTPQEFREGEDAVIVCDVV 142
                D+G+Y   V    G +S  T ++++  + +   F           G   V+ C V 
Sbjct: 7648 VAPSDSGVYSFEVQNPVGKDS-CTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVY 7706

Query: 143  SSLPPTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINF 201
             S P ++ W H+G ++   +  +  +  N   L +  ++++D G Y C    +A  +   
Sbjct: 7707 GSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDEC- 7765

Query: 202  KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE 261
                + V  PP+   + + ++     G +VT     +G P  ++SW K   ++    D  
Sbjct: 7766 -SAPLTVREPPSFVQKPDPMDVLT--GTNVTFTSIVKGTPPFSVSWFKGSSELVPG-DRC 7821

Query: 262  KYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMEL 321
                 D  ++L +  VD +   EY CI  N+AG+   T HL + A  K     N  ++E 
Sbjct: 7822 NVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEK 7881

Query: 322  EEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLT 381
             + + L    +G P  S+TW+ +  N++  ++ + T  EK   L+               
Sbjct: 7882 GKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILE--------------- 7926

Query: 382  LKSIQYTDAGEYICTASNTIGQDS---QSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEV 438
            + S    DAG+Y C   N  G+DS   Q + LE  Y  K   PV V    G+  ++ C++
Sbjct: 7927 IPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSV--GDSASLQCQL 7984

Query: 439  FAYPSATISWFR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 497
               P   +SW++ D +L P++ Y   K++   + + L       ND G Y C A N +G+
Sbjct: 7985 AGTPEIGVSWYKGDTKLRPTTTY---KMHFRNNVATLVFNQVDINDSGEYICKAENSVGE 8041

Query: 498  ESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHS 557
             S    L   +    PS  +          Q  + + T G+P++    +    G E    
Sbjct: 8042 VSASTFLTVQEQKLPPSFSR----------QLRDVQETVGLPVV---FDCAISGSEPISV 8088

Query: 558  KWY 560
             WY
Sbjct: 8089 SWY 8091



 Score =  143 bits (361), Expect = 6e-34
 Identities = 114/483 (23%), Positives = 210/483 (43%), Gaps = 45/483 (9%)

Query: 41   CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
            C++ G  + K + W+    E    ++ R+S V   DS + L ++N +++D+G Y C    
Sbjct: 7327 CKIGGSPEIK-VLWYKDETEIQESSKFRMSFV---DSVAVLEMHNLSVEDSGDYTCEAHN 7382

Query: 101  EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVIL 160
              GS S +T ++K+ +  +F+  P P E  +G D  + C++  + P  + W    R+  L
Sbjct: 7383 AAGSASSST-SLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRE--L 7439

Query: 161  KKDVRFIVLSNNYL---QIRGIKKTDEGTYRCEGRILARGEINFKDI--QVIVNVPPTIQ 215
            +   ++ ++S N+L    I  +   D G Y+C+    A  ++        + +  PP   
Sbjct: 7440 RSGKKYKIMSENFLTSIHILNVDAADIGEYQCK----ATNDVGSDTCVGSIALKAPPRFV 7495

Query: 216  ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIK 275
             + + ++    +G+ V L    EG    ++ W KD  +I +E D+    +S++ + L   
Sbjct: 7496 KKLSDISTV--VGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFS 7553

Query: 276  KVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDP 335
            +V+  +  +Y C  +N AG Q+    L V     I        +   +  TL C  +G P
Sbjct: 7554 RVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTP 7613

Query: 336  IPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 395
                           E    W +  K+ T D    +    +VS L + ++  +D+G Y  
Sbjct: 7614 ---------------ELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSF 7658

Query: 396  TASNTIGQDSQSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW 448
               N +G+DS +  L+V        +  KL+    +    G+ V + C+V+  P  ++SW
Sbjct: 7659 EVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGL---SGSSVVMECKVYGSPPISVSW 7715

Query: 449  FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD 508
            F +G  + S       +  T +   L V    E+D G+Y C A N  G +     L   +
Sbjct: 7716 FHEGNEISSGRKYQTTL--TDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVRE 7773

Query: 509  TPS 511
             PS
Sbjct: 7774 PPS 7776



 Score =  135 bits (340), Expect = 2e-31
 Identities = 134/561 (23%), Positives = 223/561 (39%), Gaps = 62/561 (11%)

Query: 34   GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
            G+S  F CQ+ G  K + +SW+    E     +  IS +   D  +T  I  A ++++G 
Sbjct: 4876 GQSTTFECQITGTPKIR-VSWYLDGNEITAIQKHGISFI---DGLATFQISGARVENSGT 4931

Query: 94   YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
            Y C    + G+ S  ++ +K+ +   F     P E  +  D  + C+V  + P  + W  
Sbjct: 4932 YVCEARNDAGTAS-CSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLK 4990

Query: 154  KGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPP 212
              R++   K        + + L I     +D G Y+C   +   G       +V +  PP
Sbjct: 4991 NNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCI--VSNEGGSCSCSTRVALKEPP 5048

Query: 213  TIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI-FSDDSSQ 271
            +   +  I N T  L  S T      G P  +++W KD + ++  EDD  YI F D  + 
Sbjct: 5049 SFIKK--IENTTTVLKSSATFQSTVAGSPPISITWLKDDQILD--EDDNVYISFVDSVAT 5104

Query: 272  LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEA 331
            L I+ VD      Y C A+N++G +     L V    +I        +  ++ +TL C  
Sbjct: 5105 LQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVV 5164

Query: 332  SGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAG 391
            +G P               E K  W +  KQ     +  +     V+S  ++S+   D+G
Sbjct: 5165 AGTP---------------ELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSG 5209

Query: 392  EYICTASNTIGQDSQSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSA 444
            +Y     N  G  S   YL V        +  KL     V    G+ +++ C+V      
Sbjct: 5210 QYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVL---GSSIHMECKVSGSLPI 5266

Query: 445  TISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 504
            +  WF+DG+ + +S  +  ++     +  LEV      D  NY C   N  G ++   IL
Sbjct: 5267 SAQWFKDGKEISTS--AKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGIL 5324

Query: 505  VQADTPS---SPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYD 561
               + PS    P   Q  P S+   V+F          ILK        G   +  KW+ 
Sbjct: 5325 TVKEPPSFLVKPGRQQAIPDST---VEFK--------AILK--------GTPPFKIKWFK 5365

Query: 562  AKEASMEGIVTIVGLKPETTY 582
                 + G    +GL+  T++
Sbjct: 5366 DDVELVSGPKCFIGLEGSTSF 5386



 Score =  129 bits (323), Expect = 2e-29
 Identities = 134/594 (22%), Positives = 233/594 (39%), Gaps = 42/594 (7%)

Query: 23   DIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLT 82
            D+ P   ++++GES  F C V G A  K I+W   N E       ++++V   ++++TLT
Sbjct: 7215 DLKPVSVDLALGESGTFKCHVTGTAPIK-ITWAKDNREIRPGGNYKMTLV---ENTATLT 7270

Query: 83   IYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV 141
            +      DAG Y C  +   G +S  A + V+   + + K  P+ +  ++ E     C +
Sbjct: 7271 VLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPS-RIVKQDEFTRYECKI 7329

Query: 142  VSSLPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200
              S    ++W     ++      R   V S   L++  +   D G Y CE    A    +
Sbjct: 7330 GGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASS 7389

Query: 201  FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
               ++  V  PP  + + + +      G  V L C+ +G P   +SW KD  ++      
Sbjct: 7390 STSLK--VKEPPIFRKKPHPIETLK--GADVHLECELQGTPPFHVSWYKDKREL---RSG 7442

Query: 261  EKYIFSDDS--SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
            +KY    ++  + + I  VD  D  EY C A N  G       + + A P+     +  +
Sbjct: 7443 KKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDIS 7502

Query: 319  MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVS 378
              + ++V L     G    S+ W      I  E    W              +     ++
Sbjct: 7503 TVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIW--------------ISYSENIA 7548

Query: 379  SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-QYAPKLQGPVAVYTWEGNQVNITCE 437
            +L    ++  +AG+Y C   N  G       L V + A  ++ P ++    G+   + C 
Sbjct: 7549 TLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECT 7608

Query: 438  VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 497
            V   P  +  WF+DG+ L S N   I  +N    S L++   + +D G Y+    N +G+
Sbjct: 7609 VAGTPELSTKWFKDGKELTSDNKYKISFFN--KVSGLKIINVAPSDSGVYSFEVQNPVGK 7666

Query: 498  ESLEFILVQADTPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEE 553
            +S    L  +D    PS    + +    S ++ V   E +  G  PI      W   G E
Sbjct: 7667 DSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVM--ECKVYGSPPI---SVSWFHEGNE 7721

Query: 554  VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 607
            +   + Y          +T+  L+   +      A N  G  E SA    +  P
Sbjct: 7722 ISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPP 7775



 Score =  125 bits (315), Expect = 1e-28
 Identities = 103/493 (20%), Positives = 210/493 (42%), Gaps = 45/493 (9%)

Query: 31   ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
            +  G+S    C++AG  + + + WF    E    ++ R++ +   DS + + + N + +D
Sbjct: 5435 VKAGDSSRLECKIAGSPEIR-VVWFRNEHELPASDKYRMTFI---DSVAVIQMNNLSTED 5490

Query: 91   AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
            +G + C      GS S +T  V + +  +F + P   E  +  +  + C++  + P  ++
Sbjct: 5491 SGDFICEAQNPAGSTSCST-KVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVV 5549

Query: 151  WKHKGRDVILKKDVRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
            W    R   L+   ++ + S N+   + I  +  +D G Y C+    A+ E+        
Sbjct: 5550 WYKDKRQ--LRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCK----AQNEVGSDTCVCT 5603

Query: 208  VNV--PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF 265
            V +  PP   ++ N +   A  G+   L    EG     + W K+ E++ +E ++ +  F
Sbjct: 5604 VKLKEPPRFVSKLNSLTVVA--GEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITF 5661

Query: 266  SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQV 325
             ++ + L   K +  +  +YIC  +N  G ++    L V     I        + + E  
Sbjct: 5662 VENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETC 5721

Query: 326  TLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSI 385
            TL C+ +G P  S+ W    + ++S +K  ++                + ++SSL + S+
Sbjct: 5722 TLECKVAGTPELSVEWYKDGKLLTSSQKHKFS---------------FYNKISSLRILSV 5766

Query: 386  QYTDAGEYICTASNTIGQDSQSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEV 438
            +  DAG Y     N +G+ S +  ++V        +  +L+    V    G    + C+V
Sbjct: 5767 ERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVL---GASCILECKV 5823

Query: 439  FAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 498
                  +++WF +   + S   +  +   + +   L++     +D GNY C A N  G +
Sbjct: 5824 AGSSPISVAWFHEKTKIVSG--AKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSD 5881

Query: 499  SLEFILVQADTPS 511
                +L   + PS
Sbjct: 5882 ECRAVLTVQEPPS 5894



 Score =  125 bits (315), Expect = 1e-28
 Identities = 112/491 (22%), Positives = 207/491 (42%), Gaps = 47/491 (9%)

Query: 34   GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
            GES    C+++G  + K +SWF  + E     +  +S +   +S + LTI  A+ +D+G 
Sbjct: 6379 GESIQLECKISGSPEIK-VSWFRNDSELHESWKYNMSFI---NSVALLTINEASAEDSGD 6434

Query: 94   YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
            Y C      G  S +T  + +    +F   P+P    +G D ++ C++  + P  ++W  
Sbjct: 6435 YICEAHNGVGDASCSTA-LTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVK 6493

Query: 154  KGRDVILKKDVRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV 210
              + V  +   +F + S ++   L I  ++ +D G Y C+    A  E+        V  
Sbjct: 6494 DRKQV--RNSKKFKITSKHFDTSLHILNLEASDVGEYHCK----ATNEVGSDTCSCSVKF 6547

Query: 211  PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270
                +  + + + +  +G +V L    EGF   ++ W KD  ++ +E ++ +  F D+ +
Sbjct: 6548 KEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIA 6607

Query: 271  QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330
             L +   + ++  +YIC  +N AG ++ +  L V    +I        +       L C 
Sbjct: 6608 TLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECV 6667

Query: 331  ASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDA 390
             +G P  S  W    R +S++ K   T   K               V+SL +   + +D 
Sbjct: 6668 VTGTPELSAKWFKDGRELSADSKHHITFINK---------------VASLKIPCAEMSDK 6712

Query: 391  GEYICTASNTIGQDSQSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEVFAYPS 443
            G Y     N++G+ + ++ + V        +  KL+   A+    G  V + C V     
Sbjct: 6713 GLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAIL---GASVVLECRVSGSAP 6769

Query: 444  ATISWFRDGQLL---PSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESL 500
             ++ WF+DG  +   P    S  +   T + S LE      +D G Y C A N  G +  
Sbjct: 6770 ISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLE-----PSDTGIYTCVAANVAGSDEC 6824

Query: 501  EFILVQADTPS 511
              +L   + PS
Sbjct: 6825 SAVLTVQEPPS 6835



 Score =  123 bits (308), Expect = 8e-28
 Identities = 119/485 (24%), Positives = 199/485 (41%), Gaps = 36/485 (7%)

Query: 34   GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
            GES    C++ G    + ++WF  N E    N  R+  V   +S + L I +  ++D+G 
Sbjct: 3752 GESARLHCKLKGSPVIQ-VTWFKNNKELSESNTVRMYFV---NSEAILDITDVKVEDSGS 3807

Query: 94   YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
            Y C    + GS+S +T  + I +   F     P +   G +A++ C+V  + P  I W  
Sbjct: 3808 YSCEAVNDVGSDSCST-EIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFK 3866

Query: 154  KGRDVILKKDVR-FIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQV--IVNV 210
              + +   K  R F   S   L+I      D G Y C    +   E+         ++  
Sbjct: 3867 DKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYEC----VVANEVGKCGCMATHLLKE 3922

Query: 211  PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270
            PPT   + + + A    GQ+VTL     G    +++W K G+++ +E+   K  FS+  +
Sbjct: 3923 PPTFVKKVDDLIALG--GQTVTLQAAVRGSEPISVTWMK-GQEVIREDGKIKMSFSNGVA 3979

Query: 271  QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330
             L I  V  +   +Y C+AEN+AG Q +   L V    KI        +   +  TL   
Sbjct: 3980 VLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYT 4039

Query: 331  ASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDA 390
             +G P               E K  W +  +         +     V+ L   S +  D+
Sbjct: 4040 VAGTP---------------ELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDS 4084

Query: 391  GEYICTASNTIGQDS---QSMYLEVQYAPKLQGPVA-VYTWEGNQVNITCEVFAYPSATI 446
            G+Y    SN +G  S       L+   AP    P+  V +       + C++       +
Sbjct: 4085 GQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRV 4144

Query: 447  SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQ 506
            SWF+DG+ + +S+    +I      + LE+     ND GN+ C A N +G +     L+ 
Sbjct: 4145 SWFKDGKEIAASD--RYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIV 4202

Query: 507  ADTPS 511
             + PS
Sbjct: 4203 QEPPS 4207



 Score =  122 bits (307), Expect = 1e-27
 Identities = 119/542 (21%), Positives = 201/542 (37%), Gaps = 49/542 (9%)

Query: 52   ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
            I WF  + E ++  +  I +   + S+S L +Y+ +    G Y C VT + GS+S  T+ 
Sbjct: 5361 IKWFKDDVELVSGPKCFIGL---EGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTML 5417

Query: 112  VKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVL-S 170
            +        K     +  + G+ + + C +  S    ++W     ++      R   + S
Sbjct: 5418 LVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDS 5477

Query: 171  NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQS 230
               +Q+  +   D G + CE +  A         +VIV  PP   +   IV    N    
Sbjct: 5478 VAVIQMNNLSTEDSGDFICEAQNPAGS--TSCSTKVIVKEPPVFSSFPPIVETLKN--AE 5533

Query: 231  VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAE 290
            V+L C+  G P   + W KD  Q+   +   K    +  + + I  VD +D  EY C A+
Sbjct: 5534 VSLECELSGTPPFEVVWYKDKRQLRSSK-KYKIASKNFHTSIHILNVDTSDIGEYHCKAQ 5592

Query: 291  NKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISS 350
            N+ G       +K+   P+     N   +   E   L     G     + W      +  
Sbjct: 5593 NEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIR 5652

Query: 351  EEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS--- 407
            E +              ++ +     V++L     +  +AG+YIC   N  G        
Sbjct: 5653 ESE--------------NIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATL 5698

Query: 408  MYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYN 467
            M LE     +  GP+ V    G    + C+V   P  ++ W++DG+LL SS       YN
Sbjct: 5699 MVLEPAVIVEKAGPMTVTV--GETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYN 5756

Query: 468  TPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQV 527
                S L +      D G Y     N +G+ S   ++  +D    PS  +          
Sbjct: 5757 --KISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTR---------- 5804

Query: 528  QFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLA 587
                 + TGGV       E +  G       W+  K         + G K +TT++  + 
Sbjct: 5805 ---RLKNTGGVLGASCILECKVAGSSPISVAWFHEKTK------IVSGAKYQTTFSDNVC 5855

Query: 588  AL 589
             L
Sbjct: 5856 TL 5857



 Score =  121 bits (303), Expect = 3e-27
 Identities = 120/479 (25%), Positives = 192/479 (40%), Gaps = 36/479 (7%)

Query: 30   EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
            E +VG+S    CQVAG   +  +SW+     KL P  +  +   N  + +TL     NI+
Sbjct: 6089 EAAVGDSVSLQCQVAG-TPEITVSWYK-GDTKLRPTPEYRTYFTN--NVATLVFNKVNIN 6144

Query: 90   DAGIYKCVVTGEDGSESEATVNVKIFQKLM---FKNAPTPQEFREGEDAVIVCDVVSSLP 146
            D+G Y C      G+ S  TV  +I ++ +   F       E   G    + C +  S P
Sbjct: 6145 DSGEYTCKAENSIGTASSKTV-FRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAP 6203

Query: 147  PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTD---EGTYRCE-GRILARGEINFK 202
              + W   G  V+L+ D        + +    I +TD    G Y C     L     + +
Sbjct: 6204 IQVCWYRDG--VLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSAR 6261

Query: 203  DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
                     P    +   ++  A  G+S    C   G     ++W+KD ++I +   +  
Sbjct: 6262 LTAREPKKSPFFDIKPVSIDVIA--GESADFECHVTGAQPMRITWSKDNKEI-RPGGNYT 6318

Query: 263  YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK-ITYVENQTAMEL 321
                 ++  L I KV K D  +Y C A N  G+   +  L V   PK +  +E     + 
Sbjct: 6319 ITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQ 6378

Query: 322  EEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLT 381
             E + L C+ SG P               E K SW R + +        +     V+ LT
Sbjct: 6379 GESIQLECKISGSP---------------EIKVSWFRNDSELHESWKYNMSFINSVALLT 6423

Query: 382  LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL-QGPVAVYTWEGNQVNITCEVFA 440
            +      D+G+YIC A N +G  S S  L V+  P   Q P  V   +G+ V + CE+  
Sbjct: 6424 INEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISG 6483

Query: 441  YPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 499
             P   + W +D + +   N    KI +    + L +     +D G Y+C A N +G ++
Sbjct: 6484 TPPFEVVWVKDRKQV--RNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDT 6540



 Score =  117 bits (292), Expect = 6e-26
 Identities = 127/558 (22%), Positives = 216/558 (38%), Gaps = 51/558 (9%)

Query: 33   VGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAG 92
            +G S    C+V+G A    + WF    E ++  + + S     ++  TL +      D G
Sbjct: 6754 LGASVVLECRVSGSAPIS-VGWFQDGNEIVSGPKCQSSF---SENVCTLNLSLLEPSDTG 6809

Query: 93   IYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWK 152
            IY CV     GS+ E +  + + +   F+  P   E   G        V+   PP  +  
Sbjct: 6810 IYTCVAANVAGSD-ECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFT-SVIRGTPPFKVKW 6867

Query: 153  HKGRDVILKKDVRFIVLSN--NYLQIRGIKKTDEGTYRCEGRILARGEINFKDI--QVIV 208
             KG   ++  +   I L +    L++  ++  + G Y C    L   +         + V
Sbjct: 6868 FKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSC----LVTNDAGSASCTTHLFV 6923

Query: 209  NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
              P T   R  + + +   G  + L     G P  ++SW KD   I Q E       ++ 
Sbjct: 6924 KEPATFVKR--LADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCS-ITMTEK 6980

Query: 269  SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
            S+ L I +    D A+Y C+ EN+AG+      + V   P            + E  TL 
Sbjct: 6981 STILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQ 7040

Query: 329  CEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYT 388
            C+  G P   I+W      + S                    ++    V+SL +  + ++
Sbjct: 7041 CKVDGTPEIRISWYKEHTKLRSAPAYK---------------MQFKNNVASLVINKVDHS 7085

Query: 389  DAGEYICTASNTIGQDSQSMYLEVQ-------YAPKLQGPVAVYTWEGNQVNITCEVFAY 441
            D GEY C A N++G  + S  L ++       +A KL+    V+   G  V   C +   
Sbjct: 7086 DVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKD---VHETLGFPVAFECRINGS 7142

Query: 442  PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG--QES 499
                +SW++DG LL     +N++     + + L++    ++  G YNC+A N +G    S
Sbjct: 7143 EPLQVSWYKDGVLLKDD--ANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSS 7200

Query: 500  LEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKW 559
             + IL + + P    +  V    +  +    +   TG  PI   K  W     E+     
Sbjct: 7201 AKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPI---KITWAKDNREIRPGGN 7257

Query: 560  YDAKEASMEGIVTIVGLK 577
            Y  K   +E   T+  LK
Sbjct: 7258 Y--KMTLVENTATLTVLK 7273



 Score =  116 bits (291), Expect = 8e-26
 Identities = 123/547 (22%), Positives = 206/547 (37%), Gaps = 48/547 (8%)

Query: 76   DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDA 135
            + +  L I N+   DAG Y C +  E G +    + V   +   F     P E   G+  
Sbjct: 6038 EKTCILEILNSTKRDAGQYSCEIENEAGRDVCGAL-VSTLEPPYFVTELEPLEAAVGDSV 6096

Query: 136  VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGRI 193
             + C V  +   T+ W +KG   +          +NN   L    +   D G Y C+   
Sbjct: 6097 SLQCQVAGTPEITVSW-YKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCK--- 6152

Query: 194  LARGEINFKDIQVIVNV-----PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWT 248
             A   I     + +  +     PP+   +   +  T  +G  VTL C   G     + W 
Sbjct: 6153 -AENSIGTASSKTVFRIQERQLPPSFARQLKDIEQT--VGLPVTLTCRLNGSAPIQVCWY 6209

Query: 249  KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
            +DG  +  +E+ +   F D+ + L I + D +   +Y C A N  G   ++  L      
Sbjct: 6210 RDGVLLRDDENLQTS-FVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPK 6268

Query: 309  KITYVENQTA---MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETL 365
            K  + + +     +   E     C  +G     ITW    + I         RP      
Sbjct: 6269 KSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEI---------RP------ 6313

Query: 366  DGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL--QGPVA 423
             G+  +        L +  +   D+G+Y C A+N +G+D  S  L V+  PK   +   +
Sbjct: 6314 GGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEAS 6373

Query: 424  VYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEND 483
                +G  + + C++   P   +SWFR+   L  S   N+   N  S + L +   S  D
Sbjct: 6374 KVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFIN--SVALLTINEASAED 6431

Query: 484  FGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFD---EPEATGGVPI 540
             G+Y C A N +G  S    L    T  +P +   +P    A    D   + E +G  P 
Sbjct: 6432 SGDYICEAHNGVGDASCSTAL----TVKAPPVFTQKPSPVGALKGSDVILQCEISGTPP- 6486

Query: 541  LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 600
              ++  W    ++V +SK +       +  + I+ L+          A N  G    S +
Sbjct: 6487 --FEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCS 6544

Query: 601  SEFKTQP 607
             +FK  P
Sbjct: 6545 VKFKEPP 6551



 Score =  116 bits (290), Expect = 1e-25
 Identities = 124/527 (23%), Positives = 203/527 (38%), Gaps = 43/527 (8%)

Query: 41   CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
            C+++G     ++ W+    +  +  + +I+   + +  +++ I N +  D G Y C    
Sbjct: 5538 CELSG-TPPFEVVWYKDKRQLRSSKKYKIA---SKNFHTSIHILNVDTSDIGEYHCKAQN 5593

Query: 101  EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVIL 160
            E GS++     VK+ +   F +         GE A +   +  + P  + W  +  +VI 
Sbjct: 5594 EVGSDT-CVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIR 5652

Query: 161  KKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQ 218
            + +   I    N   LQ    +  + G Y C+  I   G +      ++V  P  I  + 
Sbjct: 5653 ESENIRITFVENVATLQFAKAEPANAGKYICQ--IKNDGGMRENMATLMVLEPAVIVEKA 5710

Query: 219  NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD 278
              +  T  +G++ TL C   G PE ++ W KDG+ +   +   K+ F +  S L I  V+
Sbjct: 5711 GPMTVT--VGETCTLECKVAGTPELSVEWYKDGKLLTSSQK-HKFSFYNKISSLRILSVE 5767

Query: 279  KNDEAEYICIAENKAGEQDATIHLKVFAK---PKITYVENQTAMELEEQVTLTCEASGDP 335
            + D   Y    +N  G+   T  + V  +   P  T     T   L     L C+ +G  
Sbjct: 5768 RQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSS 5827

Query: 336  IPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 395
              S+ W      I S  K   T  +                V +L L S+  +D G Y C
Sbjct: 5828 PISVAWFHEKTKIVSGAKYQTTFSDN---------------VCTLQLNSLDSSDMGNYTC 5872

Query: 396  TASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQL 454
             A+N  G D     L VQ  P  ++ P  +    G  V  T  +   P   ++WFR  + 
Sbjct: 5873 VAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARE 5932

Query: 455  LPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE---FILVQADTPS 511
            L   +  NI  Y   + + LE+     +  G Y C   N  GQ S     F+   A    
Sbjct: 5933 LVKGDRCNI--YFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLK 5990

Query: 512  SPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSK 558
              S   VEP  S       E   TG +PI      W+  G  +  S+
Sbjct: 5991 RLSDHSVEPGKSIIL----ESTYTGTLPI---SVTWKKDGFNITTSE 6030



 Score =  110 bits (275), Expect = 6e-24
 Identities = 137/593 (23%), Positives = 226/593 (38%), Gaps = 40/593 (6%)

Query: 23   DIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLT 82
            DI P   ++  GES  F C V G A+   I+W   N E        I+ V N   +  L 
Sbjct: 6274 DIKPVSIDVIAGESADFECHVTG-AQPMRITWSKDNKEIRPGGNYTITCVGN---TPHLR 6329

Query: 83   IYNANIDDAGIYKCVVTGEDGSE-SEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV 141
            I      D+G Y C  T + G +   A ++VK   K + K     +  ++GE   + C +
Sbjct: 6330 ILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFV-KKLEASKVAKQGESIQLECKI 6388

Query: 142  VSSLPPTIIWKHKGRDV--ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 199
              S    + W     ++    K ++ FI  S   L I      D G Y CE      G+ 
Sbjct: 6389 SGSPEIKVSWFRNDSELHESWKYNMSFI-NSVALLTINEASAEDSGDYICEAH-NGVGDA 6446

Query: 200  NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
            +     + V  PP    + + V A    G  V L C+  G P   + W KD +Q+   + 
Sbjct: 6447 SC-STALTVKAPPVFTQKPSPVGALK--GSDVILQCEISGTPPFEVVWVKDRKQVRNSK- 6502

Query: 260  DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
              K       + L I  ++ +D  EY C A N+ G    +  +K    P+     + T+ 
Sbjct: 6503 KFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTST 6562

Query: 320  ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS 379
             + + V L     G    S+ W      +  E + +     +   +D          +++
Sbjct: 6563 LIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENT-----RISFID---------NIAT 6608

Query: 380  LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-QYAPKLQGPVAVYTWEGNQVNITCEV 438
            L L S + +++G+YIC   N  G    S  L V + A  ++ P  +    GN   + C V
Sbjct: 6609 LQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVV 6668

Query: 439  FAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 498
               P  +  WF+DG+ L + +  +I   N    + L++     +D G Y+    N +G+ 
Sbjct: 6669 TGTPELSAKWFKDGRELSADSKHHITFIN--KVASLKIPCAEMSDKGLYSFEVKNSVGKS 6726

Query: 499  SLEFILVQADTPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEV 554
            +    +  +D    PS    +  V      + V   E   +G  PI      W   G E+
Sbjct: 6727 NCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVL--ECRVSGSAPI---SVGWFQDGNEI 6781

Query: 555  WHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 607
                   +  +     + +  L+P  T      A N  G  E SA    +  P
Sbjct: 6782 VSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPP 6834



 Score =  109 bits (272), Expect = 1e-23
 Identities = 124/569 (21%), Positives = 218/569 (38%), Gaps = 48/569 (8%)

Query: 41   CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
            C++AG    + +SWF    E    ++ RI+ V   + +++L I   +++DAG + C  T 
Sbjct: 4134 CKIAGSLPMR-VSWFKDGKEIAASDRYRIAFV---EGTASLEIIRVDMNDAGNFTCRATN 4189

Query: 101  EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVIL 160
              GS+  +   + + +   F   P  ++   G    +      S P TI W  KG   ++
Sbjct: 4190 SVGSKDSSGALI-VQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRW-FKGNKELV 4247

Query: 161  KKDVRFIVLS--NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQ 218
                 +I      + L++  +K +D GTY C+   +A G     ++   V  P T   + 
Sbjct: 4248 SGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANL--FVKEPATFVEKL 4305

Query: 219  NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD 278
               +     G +  L C   G P   ++W  +  +I+ E    +  F + ++ L +  V 
Sbjct: 4306 E-PSQLLKKGDATQLACKVTGTPPIKITWFANDREIK-ESSKHRMSFVESTAVLRLTDVG 4363

Query: 279  KNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPS 338
              D  EY+C A+N+AG    +  + V   P  T       +  E  V L  E +G P   
Sbjct: 4364 IEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFE 4423

Query: 339  ITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 398
            ITW      + S  K        +  +  H+V        SL +      DAGEY C  +
Sbjct: 4424 ITWFKDNTILRSGRK-------YKTFIQDHLV--------SLQILKFVAADAGEYQCRVT 4468

Query: 399  NTIGQDSQSMYLEVQYAPKLQGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPS 457
            N +G    S  + ++  P     + +  +  G        +      T++W +D   +  
Sbjct: 4469 NEVGSSICSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITE 4528

Query: 458  SNYSNIKIYNTPSASYL---EVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD----TP 510
             +   +   N  ++ YL   EV  D     G Y C A N  G +    +L   +    T 
Sbjct: 4529 DDNIRMTFENNVASLYLSGIEVKHD-----GKYVCQAKNDAGIQRCSALLSVKEPATITE 4583

Query: 511  SSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGI 570
             + SID  +   +T QV+F   +        +  A+W   G+E+     Y         I
Sbjct: 4584 EAVSIDVTQGDPATLQVKFSGTK--------EITAKWFKDGQELTLGSKYKISVTDTVSI 4635

Query: 571  VTIVGLKPETTYAVRLAALNGKGLGEISA 599
            + I+  + + +        N  G     A
Sbjct: 4636 LKIISTEKKDSGEYTFEVQNDVGRSSCKA 4664



 Score =  108 bits (270), Expect = 2e-23
 Identities = 103/468 (22%), Positives = 190/468 (40%), Gaps = 38/468 (8%)

Query: 52   ISWFSPNGEKLTPNQQ-RISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
            + W    GE +  ++  RIS +   D+ +TL + +    ++G Y C +  + G   E + 
Sbjct: 6582 VVWLKDRGEVIRESENTRISFI---DNIATLQLGSPEASNSGKYICQIKNDAGMR-ECSA 6637

Query: 111  NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVIL--KKDVRFIV 168
             + + +       P P     G    + C V  +   +  W   GR++    K  + FI 
Sbjct: 6638 VLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFIN 6697

Query: 169  LSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV-----PPTIQARQNIVNA 223
               + L+I   + +D+G Y  E     +  +   +  V V+V     PP+   +   VNA
Sbjct: 6698 KVAS-LKIPCAEMSDKGLYSFE----VKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNA 6752

Query: 224  TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEA 283
               LG SV L C   G    ++ W +DG +I      +   FS++   L +  ++ +D  
Sbjct: 6753 I--LGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSS-FSENVCTLNLSLLEPSDTG 6809

Query: 284  EYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRT 343
             Y C+A N AG  + +  L V   P      +   +     +T T    G P   + W  
Sbjct: 6810 IYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFK 6869

Query: 344  STRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQ 403
             +R +   E  +               +     V+ L L  +Q  ++G+Y C  +N  G 
Sbjct: 6870 GSRELVPGESCN---------------ISLEDFVTELELFEVQPLESGDYSCLVTNDAGS 6914

Query: 404  DSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSN 462
             S + +L V+        +A ++ E G+ + +       P  ++SW +D  L+  S   +
Sbjct: 6915 ASCTTHLFVKEPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCS 6974

Query: 463  IKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 510
            I +  T  ++ LE+   +  D+  Y+C   N  GQ+  E ++   + P
Sbjct: 6975 ITM--TEKSTILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPP 7020



 Score =  108 bits (270), Expect = 2e-23
 Identities = 161/658 (24%), Positives = 253/658 (38%), Gaps = 91/658 (13%)

Query: 30   EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
            ++SVG+S    CQ+AG   +  +SW+  +  KL P         N+   +TL     +I+
Sbjct: 7971 KVSVGDSASLQCQLAG-TPEIGVSWYKGD-TKLRPTTTYKMHFRNN--VATLVFNQVDIN 8026

Query: 90   DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE--GEDAVIVCDVVSSLPP 147
            D+G Y C      G  S +T      QKL    +   ++ +E  G   V  C +  S P 
Sbjct: 8027 DSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPI 8086

Query: 148  TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDE---GTYRCEG-RILARGEINFKD 203
            ++ W   G+ +    +V+   L N       I KTD    G Y C     +     + + 
Sbjct: 8087 SVSWYKDGKPLKDSPNVQTSFLDNT--ATLNIFKTDRSLAGQYSCTATNPIGSASSSARL 8144

Query: 204  IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
            I      PP    R   V+A   +G+S    C   G     +SW KD  +I       KY
Sbjct: 8145 ILTEGKNPPFFDIRLAPVDAV--VGESADFECHVTGTQPIKVSWAKDSREIRS---GGKY 8199

Query: 264  IFS--DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKV---FAKPKITYVENQTA 318
              S  ++S+ LT+ KVDK D  +Y C A N+ G+   T  L +      P  T   ++T 
Sbjct: 8200 QISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETV 8259

Query: 319  MELE-EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARV 377
             E E     L    +G    ++ W  +  NI  +  ++     K  TL            
Sbjct: 8260 EETEGNSFKLEGRVAGSQPITVAWYKN--NIEIQPTSNCEITFKNNTL------------ 8305

Query: 378  SSLTLKSIQYTDAGEYICTASNTIGQD--SQSMYLEVQYAPKL--QGPVAVYTWEGNQVN 433
              L ++     DAG Y C  SN  G    + S+ ++    P +  Q    V   EG  V 
Sbjct: 8306 -VLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQ 8364

Query: 434  ITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 493
            ++C V       I W + G+ +  S+  +         + LE+   ++ D G+Y C A N
Sbjct: 8365 LSCHVQGSEPIRIQWLKAGREIKPSDRCSFSF--ASGTAVLELRDVAKADSGDYVCKASN 8422

Query: 494  RIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQ-----FDEPEA-------------- 534
              G ++ +  +   D P+      V P +  A V        EP++              
Sbjct: 8423 VAGSDTTKSKVTIKDKPA------VAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAK 8476

Query: 535  TGGVPI--LKY-KAEWRAV---GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAA 588
             GG PI  +K+ K +WR +   G    H K  +AK    +   T  GL        R  A
Sbjct: 8477 VGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGL-------YRCVA 8529

Query: 589  LNGKGLGE----ISAASEFKTQPVQGEPSA-----PKLEGQMGEDGNSIKVNLIKQDD 637
             N  G  E    +      K + ++G+  A     P L+   GE+     + L+K  D
Sbjct: 8530 FNEHGEIESNVNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLKNVD 8587



 Score =  105 bits (261), Expect = 2e-22
 Identities = 123/568 (21%), Positives = 213/568 (37%), Gaps = 48/568 (8%)

Query: 52   ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSES-EATV 110
            ++W   + E    +  R++    +++ ++L +    +   G Y C    + G +   A +
Sbjct: 4517 VTWLKDSDEITEDDNIRMTF---ENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALL 4573

Query: 111  NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
            +VK  +           +  +G+ A +      +   T  W   G+++ L    +  V  
Sbjct: 4574 SVK--EPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTD 4631

Query: 171  N-NYLQIRGIKKTDEGTYRCE-----GRILARGEINFKDIQVIVNVPPTIQARQNIVNAT 224
              + L+I   +K D G Y  E     GR   +  IN  D+ +    PP+   +   +++ 
Sbjct: 4632 TVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLII----PPSFTKKLKKMDSI 4687

Query: 225  ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
               G  + L C   G    ++ W KD ++I   E   K+ F D+++ L I +++  D   
Sbjct: 4688 K--GSFIDLECIVAGSHPISIQWFKDDQEISASEK-YKFSFHDNTAFLEISQLEGTDSGT 4744

Query: 285  YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTS 344
            Y C A NKAG    + HL V   P          +    +V L     G    +I W   
Sbjct: 4745 YTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKD 4804

Query: 345  TRNI-SSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQ 403
             + + S   ++ W    K +T             +SL L + + TD+G YIC  SN +G 
Sbjct: 4805 NKELHSGAARSVW----KDDT------------STSLELFAAKATDSGTYICQLSNDVGT 4848

Query: 404  DSQSMYLEVQYAP---KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNY 460
             +    L V+  P   K   PV V    G      C++   P   +SW+ DG  + +   
Sbjct: 4849 ATSKATLFVKEPPQFIKKPSPVLVLR-NGQSTTFECQITGTPKIRVSWYLDGNEITAIQK 4907

Query: 461  SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEP 520
              I   +    +  +++     + G Y C A N  G  S    L   + P+   I +++P
Sbjct: 4908 HGISFID--GLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPT--FIRELKP 4963

Query: 521  YSSTAQVQFD-EPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPE 579
                     + E E TG  P   ++  W     E+  SK Y   +      + I    P 
Sbjct: 4964 VEVVKYSDVELECEVTGTPP---FEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPS 5020

Query: 580  TTYAVRLAALNGKGLGEISAASEFKTQP 607
             T   +    N  G    S     K  P
Sbjct: 5021 DTGEYQCIVSNEGGSCSCSTRVALKEPP 5048



 Score =  100 bits (250), Expect = 4e-21
 Identities = 102/459 (22%), Positives = 182/459 (39%), Gaps = 44/459 (9%)

Query: 52   ISWFSPNGEKLTPNQQ-RISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
            + W     E +  ++  RI+ V N    +TL    A   +AG Y C +   DG   E   
Sbjct: 5641 VQWLKEKEEVIRESENIRITFVEN---VATLQFAKAEPANAGKYICQIKN-DGGMRENMA 5696

Query: 111  NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
             + + +  +      P     GE   + C V  +   ++ W   G+ +   +  +F   +
Sbjct: 5697 TLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYN 5756

Query: 171  N-NYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV-----PPTIQARQNIVNAT 224
              + L+I  +++ D GTY  +     +  +       +V+V     PP+   R  + N  
Sbjct: 5757 KISSLRILSVERQDAGTYTFQ----VQNNVGKSSCTAVVDVSDRAVPPSFTRR--LKNTG 5810

Query: 225  ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY--IFSDDSSQLTIKKVDKNDE 282
              LG S  L C   G    +++W  +  +I       KY   FSD+   L +  +D +D 
Sbjct: 5811 GVLGASCILECKVAGSSPISVAWFHEKTKIVS---GAKYQTTFSDNVCTLQLNSLDSSDM 5867

Query: 283  AEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMEL--EEQVTLTCEASGDPIPSIT 340
              Y C+A N AG  +    L V   P  ++V+    +E+   + VT T    G P   + 
Sbjct: 5868 GNYTCVAANVAGSDECRAVLTVQEPP--SFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVN 5925

Query: 341  WRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 400
            W    R +   ++ +               +     V+ L L +I  + +GEY C  SN 
Sbjct: 5926 WFRGARELVKGDRCN---------------IYFEDTVAELELFNIDISQSGEYTCVVSNN 5970

Query: 401  IGQDSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSN 459
             GQ S +  L V+        ++ ++ E G  + +          +++W +DG  + +S 
Sbjct: 5971 AGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSE 6030

Query: 460  YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 498
              N  I  T     LE+   ++ D G Y+C   N  G++
Sbjct: 6031 KCN--IVTTEKTCILEILNSTKRDAGQYSCEIENEAGRD 6067



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 120/471 (25%), Positives = 180/471 (38%), Gaps = 41/471 (8%)

Query: 52   ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSE-SEATV 110
            +SW     E L    +R S+   +  S+ L I  + I+D   Y C++  E G +  EA V
Sbjct: 6958 VSWIKD--EYLISQSERCSITMTE-KSTILEILESTIEDYAQYSCLIENEAGQDICEALV 7014

Query: 111  NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
            +V   +   F       E   GE A + C V  +    I W +K    +       +   
Sbjct: 7015 SV--LEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISW-YKEHTKLRSAPAYKMQFK 7071

Query: 171  NNY--LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIV--NVPPTIQARQNIVNATAN 226
            NN   L I  +  +D G Y C+      G +    + VI    +PP    +   V+ T  
Sbjct: 7072 NNVASLVINKVDHSDVGEYSCKADNSV-GAVASSAVLVIKARKLPPFFARKLKDVHET-- 7128

Query: 227  LGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYI 286
            LG  V   C   G     +SW KDG  ++ + + +   F  + + L I + D++   +Y 
Sbjct: 7129 LGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTS-FVHNVATLQILQTDQSHIGQYN 7187

Query: 287  CIAENKAGEQDATIHLKVF---AKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRT 343
            C A N  G   ++  L +      P          + L E  T  C  +G     ITW  
Sbjct: 7188 CSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAK 7247

Query: 344  STRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQ 403
              R I        T  E   TL               T+  +   DAG+Y C ASN  G+
Sbjct: 7248 DNREIRPGGNYKMTLVENTATL---------------TVLKVGKGDAGQYTCYASNIAGK 7292

Query: 404  DSQSMYLEVQYAP----KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSN 459
            DS S  L VQ  P    KL+    V   E  +    C++   P   + W++D   +  S 
Sbjct: 7293 DSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYE--CKIGGSPEIKVLWYKDETEIQES- 7349

Query: 460  YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 510
             S  ++    S + LE+   S  D G+Y C A N  G  S    L   + P
Sbjct: 7350 -SKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPP 7399



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 153/630 (24%), Positives = 235/630 (37%), Gaps = 99/630 (15%)

Query: 30   EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
            E+ V E +  + +   +  D D  W+    E     Q+R   V  +     + I      
Sbjct: 3155 EVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVV-ERRIHRMFISETRQS 3213

Query: 90   DAGIYKCVVTGEDGSESEATVNV----KIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSL 145
            DAG Y   V G + S     VN     ++ Q+L       P   + G+ A   C V+S  
Sbjct: 3214 DAGEYT-FVAGRNRSSVTLYVNAPEPPQVLQELQ------PVTVQSGKPARF-CAVISGR 3265

Query: 146  P-PTIIWKHKGRDVILKKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGR---------- 192
            P P I W  + + +      +F+     Y  L I    + D   Y CE +          
Sbjct: 3266 PQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPE-DAAVYTCEAKNDYGVATTSA 3324

Query: 193  --ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
               +   E+   D ++ V  P  I   Q+ V +    GQ     C   G  +  +SW   
Sbjct: 3325 SLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSE---GQPARFQCRVSG-TDLKVSWYSK 3380

Query: 251  GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310
             ++I+         F +D+ QL I +    DE  Y  +A N  G+  +T +L + A   I
Sbjct: 3381 DKKIKPSRFFRMTQF-EDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESI 3439

Query: 311  TY--VENQTAMELEEQVTL-----------------TCEASGDPIPSITWRTSTRNISSE 351
             +  +E +  ME++    +                 TCE    P     W  + R I   
Sbjct: 3440 LHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYES 3499

Query: 352  EKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLE 411
            +K S               +RS   +SSL +   Q  D GEY C ASN  G  S +  L 
Sbjct: 3500 DKCS---------------IRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLT 3544

Query: 412  V--QYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLL-PSSNYSNIKIYN 467
            V   Y P  L  P ++ T+ G      C V   P     W +DG  L PS N+   +I +
Sbjct: 3545 VTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNW---RISD 3601

Query: 468  TPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSST--- 524
              +   LE++  +  D G Y+C A N+ G +  +  L+  D P    I ++EP  S    
Sbjct: 3602 AENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPH--FIKELEPVQSAINK 3659

Query: 525  ---AQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWY----DAKEASMEGIVTIVGLK 577
                + Q DE          K    W   G+++   K Y    + K A++E  + +  LK
Sbjct: 3660 KVHLECQVDEDR--------KVTVTWSKDGQKLPPGKDYKICFEDKIATLE--IPLAKLK 3709

Query: 578  PETTYAVRLAALNGKGLGEISAASEFKTQP 607
               TY     A N  G    SA    +  P
Sbjct: 3710 DSGTYV--CTASNEAGSSSCSATVTVREPP 3737



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 133/609 (21%), Positives = 228/609 (37%), Gaps = 78/609 (12%)

Query: 41   CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
            C V        ISW+    E+L     +   + +D    TL +  A  +DA +Y C    
Sbjct: 3259 CAVISGRPQPKISWYKE--EQLLSTGFKCKFL-HDGQEYTLLLIEAFPEDAAVYTCEAKN 3315

Query: 101  EDG-SESEATVNVKIFQKLM-FKNAP-------TPQE---FREGEDAVIVCDVVSSLPPT 148
            + G + + A+++V++ + +   +  P       TP +     EG+ A   C V S     
Sbjct: 3316 DYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRV-SGTDLK 3374

Query: 149  IIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTY-----RCEGRILARGEINFK 202
            + W  K + +   +  R     + Y L+I      DEGTY        G++ +   ++ +
Sbjct: 3375 VSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLE 3434

Query: 203  ------------DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
                        +I++ +   P I  ++ I      LG      C+ +  P     W K 
Sbjct: 3435 APESILHERIEQEIEMEMKAAPVI--KRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKA 3492

Query: 251  GEQIEQEED----DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306
            G +I + +       KYI     S L I +    D  EY C A N+ G    T  L V  
Sbjct: 3493 GREIYESDKCSIRSSKYI-----SSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTE 3547

Query: 307  KPKITYVENQTAME--LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQET 364
                T++    ++   + +     C  +G P+    W+     +S       +  E +  
Sbjct: 3548 AYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHI 3607

Query: 365  LDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD-SQSMYLEVQYAPKLQGPVA 423
            L+          +S+LT++     D G Y C ASN  G D  Q+  + +     ++    
Sbjct: 3608 LE----------LSNLTIQ-----DRGVYSCKASNKFGADICQAELIIIDKPHFIKELEP 3652

Query: 424  VYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEND 483
            V +    +V++ C+V      T++W +DGQ LP     + KI      + LE+      D
Sbjct: 3653 VQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGK--DYKICFEDKIATLEIPLAKLKD 3710

Query: 484  FGNYNCTAVNRIGQESLEFILVQADTPS-----SPSIDQVEPYSSTAQVQFDEPEATGGV 538
             G Y CTA N  G  S    +   + PS      PS   +   S+    +        G 
Sbjct: 3711 SGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLK------GS 3764

Query: 539  PILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 598
            P++  +  W    +E+  S        + E I+ I  +K E + +    A+N  G    S
Sbjct: 3765 PVI--QVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCS 3822

Query: 599  AASEFKTQP 607
                 K  P
Sbjct: 3823 TEIVIKEPP 3831



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 109/539 (20%), Positives = 194/539 (35%), Gaps = 35/539 (6%)

Query: 76   DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDA 135
            DS +TL I + +   +G Y C    E G E      + + +           +  E +  
Sbjct: 5100 DSVATLQIRSVDNGHSGRYTCQAKNESGVE-RCYAFLLVQEPAQIVEKAKSVDVTEKDPM 5158

Query: 136  VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS--NNY--LQIRGIKKTDEGTYRCEG 191
             + C V  +    + W   G+ ++     R+  +S  NN    +I+ + K D G Y  + 
Sbjct: 5159 TLECVVAGTPELKVKWLKDGKQIVPS---RYFSMSFENNVASFRIQSVMKQDSGQYTFKV 5215

Query: 192  RILARGEINFKDIQVI-VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
                        ++V+  N+PP+   +   ++    LG S+ + C   G    +  W KD
Sbjct: 5216 ENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKV--LGSSIHMECKVSGSLPISAQWFKD 5273

Query: 251  GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310
            G++I       + +  + S  L +  ++  D A Y C   N AG+   +  L V   P  
Sbjct: 5274 GKEISTSAK-YRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSF 5332

Query: 311  TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMV 370
                 +     +  V       G P   I W      + S  K                 
Sbjct: 5333 LVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKC---------------F 5377

Query: 371  VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL--QGPVAVYTWE 428
            +      S L L S+  +  G+Y C  +N +G DS +  L V   PK   +   +     
Sbjct: 5378 IGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKA 5437

Query: 429  GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
            G+   + C++   P   + WFR+   LP+S+   +   +  S + +++   S  D G++ 
Sbjct: 5438 GDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFID--SVAVIQMNNLSTEDSGDFI 5495

Query: 489  CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWR 548
            C A N  G  S    ++  + P   S   +      A+V   E E +G  P   ++  W 
Sbjct: 5496 CEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSL-ECELSGTPP---FEVVWY 5551

Query: 549  AVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 607
                ++  SK Y     +    + I+ +           A N  G        + K  P
Sbjct: 5552 KDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPP 5610



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 150/693 (21%), Positives = 265/693 (38%), Gaps = 78/693 (11%)

Query: 39    FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVV 98
             F C+V  + +     WF  N E +  + + I  +   D   TL I +A++DD   Y   +
Sbjct: 12659 FNCEV--NTEGAKAKWFR-NEEAIFDSSKYI--ILQKDLVYTLRIRDAHLDDQANYNVSL 12713

Query: 99    TGEDGSESEATVNVKIFQKLMFKNAPTPQ-EFREGEDAVIVCDVVSSLPPTIIWKHKGRD 157
             T   G   ++  N+ + ++ +    P    E  E +     C V + L  T+ W   G +
Sbjct: 12714 TNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKV-NRLNVTLKWTKNGEE 12772

Query: 158   VILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQA 216
             V     V + V    + L I+     DEG Y     I+  G+   K +  ++ +    + 
Sbjct: 12773 VPFDNRVSYRVDKYKHMLTIKDCGFPDEGEY-----IVTAGQD--KSVAELLIIEAPTEF 12825

Query: 217   RQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS--QLTI 274
              +++ + T          C      +  + W ++G +I++    +KY F  D S  +L I
Sbjct: 12826 VEHLEDQTVTEFDDAVFSCQLSR-EKANVKWYRNGREIKE---GKKYKFEKDGSIHRLII 12881

Query: 275   KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGD 334
             K    +DE EY C      G +D     ++F +        +  +E+        EA G 
Sbjct: 12882 KDCRLDDECEYAC------GVEDRKSRARLFVE--------EIPVEIIRPPQDILEAPGA 12927

Query: 335   PIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 394
              +  +      +      +  W R            + S  ++  L +  I+  D GEY 
Sbjct: 12928 DVVFLAELNKDK-----VEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEY- 12981

Query: 395   CTASNTIGQDSQSMY-LEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRDG 452
                   I +D ++   LE+  APK++     +    G  + +     AYP A   WF++ 
Sbjct: 12982 ----RFIAKDKEARAKLELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKEN 13037

Query: 453   QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSS 512
             + L +       I  T   +   +    + D G Y     N+ G+      L   D P  
Sbjct: 13038 EPLSTKT-----IDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGP 13092

Query: 513   P-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIV 571
               +++  E +     + ++EP   GG  I+ Y  E R    ++    W  A + +     
Sbjct: 13093 VRNLEVTETFDGEVSLAWEEPLTDGGSKIIGYVVERR----DIKRKTWVLATDRAESCEF 13148

Query: 572   TIVGL-KPETTYAVRLAALNGKGLGE-------ISAASEFKTQPVQGEPSAPKLEGQMGE 623
             T+ GL K    Y  R++A N  G GE       + A S++    V G P    +      
Sbjct: 13149 TVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKY---DVPGPPLNVTI-----T 13200

Query: 624   DGNSIKVNLI---KQDDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLDWNAE 679
             D N   V+L     + DGG+ I +Y++  R  +S  W   + + +      +  +    E
Sbjct: 13201 DVNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQE 13260

Query: 680   YEVYVVAENQQGKSK-AAHFVFRTSAQPTAIPA 711
             Y   V A+N+ G  K +A   F   A P   P+
Sbjct: 13261 YSFRVRAQNRIGVGKPSAATPFVKVADPIERPS 13293



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 99/412 (24%), Positives = 165/412 (40%), Gaps = 44/412 (10%)

Query: 315   NQTAMELEEQVTLTCEASGDPIPS--ITWRTSTRNISSEEKASWTRPEKQ--ETLDGHMV 370
             N+  + L  + T   + S  P+P   +T    TRN ++     W +PE      + G++V
Sbjct: 25276 NEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTAT---IKWEKPESDGGSKITGYVV 25332

Query: 371   ---VRSHARVSSLT-LKSIQYTDAG-----EYI--CTASNTIGQDSQSMY------LEVQ 413
                 +   + S+ T +K+++ T +G     EY+    A N  G+             +++
Sbjct: 25333 EMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIE 25392

Query: 414   YAPKLQGPVAVYTWEGN-QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSAS 472
               P ++ P   +  +   Q+ I       P AT++W +DGQ L  +   N+    T ++ 
Sbjct: 25393 IKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTS- 25451

Query: 473   YLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS---IDQVEPYSSTAQVQF 529
              L +   S+ D G Y     N  G  ++   ++  D P  P    ID+V   S T  + +
Sbjct: 25452 -LSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSIT--ISW 25508

Query: 530   DEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL 589
             + PE  GG  I  Y  E +      WH       +A     + IV L   + Y  R+ A 
Sbjct: 25509 NPPEYDGGCQISNYIVEKKETTSTTWHI----VSQAVARTSIKIVRLTTGSEYQFRVCAE 25564

Query: 590   NGKGLGEISAAS----EFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHY 645
             N  G    S +S    E+   P  G P  PK+          +    +  +DGGS +  Y
Sbjct: 25565 NRYGKSSYSESSAVVAEYPFSP-PGPPGTPKVVH--ATKSTMLVTWQVPVNDGGSRVIGY 25621

Query: 646   LVRYRALSSE-WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 696
              + Y+  SS  W    ++      + +  LD    YE  V AEN  G  K +
Sbjct: 25622 HLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCS 25673



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 70/276 (25%), Positives = 112/276 (40%), Gaps = 51/276 (18%)

Query: 174   LQIRGIKKTDEGTYRCE-----GRILARGEINFKDIQVIVN-----VPPTIQARQN---- 219
             L ++ I K D+GTYRC+     G   +  E+  K ++ + +         I+ R +    
Sbjct: 31626 LYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRL 31685

Query: 220   ----------IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269
                       + N TA +G++V         PEP ++W K G++I+  ++D+KY F  D 
Sbjct: 31686 LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDK 31745

Query: 270   S--QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKIT----------YVENQT 317
                QLTI  V  +D+AEY  +A NK GE      L V   P  T           + N  
Sbjct: 31746 GLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAE 31805

Query: 318   AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARV 377
               E  + V      SG P P++ W    + +S                    ++      
Sbjct: 31806 CQE-GQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIE--------------IIHEGLDY 31850

Query: 378   SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 413
              +L ++     D G Y  TA+NT G  S   +L+V+
Sbjct: 31851 YALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVE 31886



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 110/430 (25%), Positives = 167/430 (38%), Gaps = 45/430 (10%)

Query: 314   ENQTAMELEEQVTLTCEASGDPIP--SITWRTSTRNISSEEKASWTRPEKQ--------- 362
             EN+  + L  Q     + +  P P   IT    TRN  S    SWT+PE           
Sbjct: 23110 ENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVS---LSWTKPEHDGGSKIIQYI 23166

Query: 363   -ETLDGHMVVRSH-ARVSSLTLKSIQYTDAGEYI--CTASNTIGQ-DSQSMYL-----EV 412
              E    H    S  ARV SL       T   EY+    A N  G+ D +S+ +     ++
Sbjct: 23167 VEMQAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDL 23226

Query: 413   QYAPKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSA 471
                P ++   + Y+ + G  + I   +   P  TI+W +DG  LP    + I + ++   
Sbjct: 23227 VIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDG--LPLKQTTRINVTDSLDL 23284

Query: 472   SYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSP----SIDQVEPYSSTAQV 527
             + L +    ++D G Y  T  N +GQ++    +V  D P  P      D V   S T  +
Sbjct: 23285 TTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESIT--L 23342

Query: 528   QFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASM-EGIVTIVGLKPETTYAVRL 586
              ++ P  TGG  I  Y  + R     VW     D   A++    + +  LK  T Y  R+
Sbjct: 23343 SWNPPLYTGGCQITNYIVQKRDTTTTVW-----DVVSATVARTTLKVTKLKTGTEYQFRI 23397

Query: 587   AALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSP-IRH 644
              A N  G      +     Q    EP  P          +S+ +   +  ++GGSP I +
Sbjct: 23398 FAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGY 23457

Query: 645   YLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAH----FVF 700
             +L R    S  W    +          ++L+   EYE  V AEN  G  KA+     +V 
Sbjct: 23458 HLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVA 23517

Query: 701   RTSAQPTAIP 710
             R    P   P
Sbjct: 23518 RDPCDPPGTP 23527



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 72/268 (26%), Positives = 115/268 (42%), Gaps = 15/268 (5%)

Query: 429   GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
             G    +T      P   + W +    L +  Y    +  T S + L +   + ND G Y 
Sbjct: 26201 GASFTMTVPFRGRPVPNVLWSKPDTDLRTRAY----VDTTDSRTSLTIENANRNDSGKYT 26256

Query: 489   CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGVPILKYKAEW 547
              T  N +   SL  ++   DTP  P+   V+  +  +A + +D PE  GG P+  Y  E 
Sbjct: 26257 LTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEK 26316

Query: 548   RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 607
             R   ++ W S   +    S +    +  L+    Y  R++  N  G+G  +   E     
Sbjct: 26317 REASKKAWVSVTNNCNRLSYK----VTNLQEGAIYYFRVSGENEFGVGIPAETKE--GVK 26370

Query: 608   VQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLVRYRALSSEWKPEIRLP-SG 665
             +  +PS P+  G      +S+ +  +K + DGGS I HY+V   AL    K  ++   + 
Sbjct: 26371 ITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVV--EALEKGQKNWVKCAVAK 26428

Query: 666   SDHVMLKSLDWNAEYEVYVVAENQQGKS 693
             S H ++  L  N+EY   V AENQ G S
Sbjct: 26429 STHHVVSGLRENSEYFFRVFAENQAGLS 26456



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 80/308 (25%), Positives = 119/308 (38%), Gaps = 23/308 (7%)

Query: 416   PKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYL 474
             P L+ P   Y+ + G  + I   V   P   ISW +DG+  P    + + +  T +++ L
Sbjct: 24312 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGE--PLKQTTRVNVEETATSTVL 24369

Query: 475   EVTPDSENDFGNYNCTAVNRIG--QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEP 532
              +   +++DFG Y  TA N  G   E+L  I+++   P    +   E  +    + ++ P
Sbjct: 24370 HIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPP 24429

Query: 533   EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGK 592
               TGG  I  Y  E R      WH              + I  LK  T Y  R+ A N  
Sbjct: 24430 AYTGGCQISNYIVEKRDTTTTTWHM----VSATVARTTIKITKLKTGTEYQFRIFAENRY 24485

Query: 593   GLGEISAASEFKTQPVQ------GEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYL 646
             G    SA  + K   VQ      G P  P +   + +D   ++ +    D G   I ++L
Sbjct: 24486 GK---SAPLDSKAVIVQYPFKEPGPPGTPFVT-SISKDQMLVQWHEPVNDGGTKIIGYHL 24541

Query: 647   VRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAH----FVFRT 702
              +    S  W    + P          LD   EYE  V AEN  G  K +     FV R 
Sbjct: 24542 EQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARD 24601

Query: 703   SAQPTAIP 710
                P   P
Sbjct: 24602 PCDPPGRP 24609



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 128/580 (22%), Positives = 210/580 (36%), Gaps = 55/580 (9%)

Query: 137   IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
             I+  V    PPT+ W    R +  +  +    +S++ + I+  +++ +G Y     +LA+
Sbjct: 16544 IIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMV-IKNCQRSHQGVYS----LLAK 16598

Query: 197   GEINFKDIQVIVNV--PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254
              E   +   +IV+V   P       + +   N    +T     +    P  ++      I
Sbjct: 16599 NEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYV-----I 16653

Query: 255   EQEEDDEK----YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQD--ATIHLKVFAKP 308
             E+ E D +      ++      T++ + +     +   AEN  G      T    V  +P
Sbjct: 16654 EKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREP 16713

Query: 309   KITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGH 368
              IT  E    +E++E    T   + +P P     +   N   E +   T          H
Sbjct: 16714 -ITVPERPEDLEVKEVTKNTVTLTWNP-PKYDGGSEIINYVLESRLIGTEKF-------H 16764

Query: 369   MVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLE-VQYAPKLQGPVAVYTW 427
              V   +      T+K ++  D  EY  +A N +GQ   S   + +    +L  P     +
Sbjct: 16765 KVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDF 16824

Query: 428   EGNQVNITCEVFAY-------PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 480
                      E FA        P   +SWF+D   +   + ++IK   TP+   LE     
Sbjct: 16825 RDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIK--TTPATLALEKIKAK 16882

Query: 481   ENDFGNYNCTAVNRIGQESLEFILVQADTPSSP----SIDQVEPYSSTAQVQFDEPEATG 536
              +D G Y     N  G       +   D P  P    S D+V        + +  P   G
Sbjct: 16883 RSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVT--KDYMVISWKPPLDDG 16940

Query: 537   GVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 596
             G  I  Y  E + VG++V    W     AS +    +  L     Y  R+ A N  G+ +
Sbjct: 16941 GSKITNYIIEKKEVGKDV----WMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISD 16996

Query: 597   ISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYR-ALSSE 655
                +   K +     P AP          +S  V   K  DGG PI +Y++  R  +S  
Sbjct: 16997 PLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKR 17056

Query: 656   WKPEIRLPSGSDHVMLK----SLDWNAEYEVYVVAENQQG 691
             W    R+     H   K     L    +YE  V AEN+ G
Sbjct: 17057 W---ARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIG 17093



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 152/676 (22%), Positives = 258/676 (38%), Gaps = 120/676 (17%)

Query: 76    DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDA 135
             DS STLT+ N N +DAG Y   V    GS+S  T  VK+         P P  F++    
Sbjct: 28408 DSFSTLTVENCNRNDAGKYTLTVENNSGSKS-ITFTVKVLDT---PGPPGPITFKD---- 28459

Query: 136   VIVCDVVSSLPPTIIWKHKGRD--------VILKKDVRF----IVLSNNYLQIRGIKKTD 183
                   V+    T++W     D        V+ K++       ++      QI  +    
Sbjct: 28460 ------VTRGSATLMWDAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLA 28513

Query: 184   EGT---YRCEG-RILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEG 239
             EG    +R         GE       ++    P    R ++V+ + +      L  D +G
Sbjct: 28514 EGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDG 28573

Query: 240   FPEPTMSWTKDGEQIE-QEEDDEKYIFSDDSSQLT--IKKVDKNDEAEYICIAENKAG-- 294
                 T      G  +E +++  + ++ +  + QLT  ++++ +  E E+   A+N AG  
Sbjct: 28574 GSRIT------GYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYS 28627

Query: 295   EQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEA----------SGDPIPSITWRTS 344
             E        +  +P+I    + T +  +    +TC+A          SG P P +TW+  
Sbjct: 28628 EPREAFSSVIIKEPQIEPTADLTGITNQ---LITCKAGSPFTIDVPISGRPAPKVTWKLE 28684

Query: 345   TRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD 404
                +   ++ S T  + + T               LT+K     D+G Y  T  NT G  
Sbjct: 28685 EMRLKETDRVSITTTKDRTT---------------LTVKDSMRGDSGRYFLTLENTAGVK 28729

Query: 405   SQSMYLEVQYAP-KLQGPV---------AVYTW----EGNQVNITCEVF-AYPSATISWF 449
             + S+ + V   P  + GP+          V +W    +G    IT  +     S T +W 
Sbjct: 28730 TFSVTVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAW- 28788

Query: 450   RDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQAD 508
                  L +S+    +I  T    Y+E          ++  ++ NR G  + LE   + A+
Sbjct: 28789 ----QLVNSSVKRTQIKVTHLTKYMEY---------SFRVSSENRFGVSKPLESAPIIAE 28835

Query: 509   ----TPSSPSIDQVEPYSSTA-QVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 563
                  PS+P+  +V   S+ A  ++++EP   GG  I+ Y  E +     +W     + K
Sbjct: 28836 HPFVPPSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVK---ENK 28892

Query: 564   EASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE-FKTQPVQGEPSAPKLEGQMG 622
                +E    + GL     Y  R  ALN  G+ + S AS     Q     P  P++     
Sbjct: 28893 VPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEV----- 28947

Query: 623   EDGNSIKVNLI---KQDDGGSPIRHYLVRYRALS----SEWKPEIRLPSGSDHVMLKSLD 675
              D     V+LI      DGGS +  Y++  + +S      W          +   + +L 
Sbjct: 28948 TDVTRSTVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALS 29007

Query: 676   WNAEYEVYVVAENQQG 691
                 YE  V+A+N  G
Sbjct: 29008 EGDTYEFRVLAKNAAG 29023



 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 114/524 (21%), Positives = 202/524 (38%), Gaps = 65/524 (12%)

Query: 217   RQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD--SSQLTI 274
             R+ + + T  LG++  L C   G P P + W + G+++ Q     KY  S D  +  LT+
Sbjct: 30536 RKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ---SRKYKMSSDGRTHTLTV 30592

Query: 275   KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI---TYVENQTAMELEEQVTLTCEA 331
                ++ DE  Y CIA N+ GE + +  L + A P+      ++ +    +   + L    
Sbjct: 30593 MTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMY 30652

Query: 332   SGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQ-YTDA 390
              G P+P++TW    + + + E               ++ + +    + L +K++Q  T A
Sbjct: 30653 IGRPVPAMTWFHGQKLLQNSE---------------NITIENTEHYTHLVMKNVQRKTHA 30697

Query: 391   GEYICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISWF 449
             G+Y    SN  G     + +E+Q  P K  GP+ +     N   I+ +  A      SW 
Sbjct: 30698 GKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGG--SWI 30755

Query: 450   -------------RDGQLLPSS-NYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 495
                           + QL+ S+ + +  +I N    +       ++N FG  +   V+ +
Sbjct: 30756 TNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSV 30815

Query: 496   GQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW 555
                 ++    +   P  P+I  V     +  V +  P + GG  I  Y  E R   +  W
Sbjct: 30816 --VIIKSPFEKPGAPGKPTITAVT--KDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKW 30871

Query: 556   HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAP 615
              S      E   E + ++  L     Y  R+   N  G  E S  SE    P+  +   P
Sbjct: 30872 ISV---TTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISE----PITPKSDVP 30924

Query: 616   KLEGQMGEDGNSIKVN-------LIKQDDGGSPI-RHYLVRYRALSSEWKPEIRLPSGSD 667
                    E+  ++ V        + K      PI + Y      ++   K  I+   G  
Sbjct: 30925 IQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGY 30984

Query: 668   HVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPA 711
             H ++ +   + +  VY V    QG S     V  T++    +PA
Sbjct: 30985 HQLIIASVTDDDATVYQVRATNQGGS-----VSGTASLEVEVPA 31023



 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 84/409 (20%), Positives = 168/409 (41%), Gaps = 43/409 (10%)

Query: 21    QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQ-RISVVWNDDSSS 79
             ++    +Q  I+ G+       +AG     D+ W   NG +LT +++ R  V  +D    
Sbjct: 33040 EIKAFSTQMSINEGQRLVLKANIAGAT---DVKWVL-NGVELTNSEEYRYGVSGSDQ--- 33092

Query: 80    TLTIYNANIDDAGIYKCVVTGEDG---SESEATVNVKIFQKLMFKNAPTPQEFREGEDAV 136
             TLTI  A+  D GI  C+   ++G    + + T++ ++     F + P  Q   EG++ +
Sbjct: 33093 TLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVL 33152

Query: 137   IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILA 195
               C++     P I W      + +  +V      N Y L+IR    +D G Y  + +   
Sbjct: 33153 FTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNF- 33211

Query: 196   RGEINFKDIQVIVNVPPTIQARQNIVNATAN--------LGQSVTLVCDAEGFPEPTMSW 247
             RG+ +     ++  +P   +  + +V  T+           QSV +    +   E + S 
Sbjct: 33212 RGQCSATASLMV--LPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQ---EASFSS 33266

Query: 248   TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK 307
                       E     + +   S +    V+ +  + ++ I+     E   +  LK   +
Sbjct: 33267 FSSSSASSMTEMKFASMSAQSMSSMQESFVEMS-SSSFMGISNMTQLESSTSKMLKAGIR 33325

Query: 308   ---PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQET 364
                PKI  + +  +++  + +T+ C  +G+P P +TW    R I S+E+           
Sbjct: 33326 GIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQ----------- 33374

Query: 365   LDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 413
               G   + +   +++L +  +Q  D G Y  +  N  G DS ++ + ++
Sbjct: 33375 --GRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 90/355 (25%), Positives = 138/355 (38%), Gaps = 20/355 (5%)

Query: 348   ISSEEKAS--WTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDS 405
             I ++ K S  WT     + L+   VVR+       T + +    AG      S  +    
Sbjct: 21001 IEAQRKGSDQWTHITTVKGLE--CVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKE 21058

Query: 406   QSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKI 465
             Q+M  E+      Q  V      G+ + +   V   P  T++W +  Q+L  +   N + 
Sbjct: 21059 QTMLPELDLRGIYQKLVIAKA--GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFE- 21115

Query: 466   YNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS--IDQVEPYSS 523
               T +++ L +     +D G Y  TA N +G+      +   D P  P+  I   E  S 
Sbjct: 21116 -TTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSD 21174

Query: 524   TAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYA 583
                  +D PE  GGVPI  Y  E R      W          + +      GL+    Y 
Sbjct: 21175 FVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLE----YQ 21230

Query: 584   VRLAALNGKGLGE-ISAASEFKTQP--VQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGS 640
              R+ A N  G+G  I++A      P  V G P  P++   + +D  +I  +     DGGS
Sbjct: 21231 FRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTA-VTKDSMTISWH-EPLSDGGS 21288

Query: 641   PIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 694
             PI  Y V  +  +   W+   +     +      L     YE  V+AEN  GKSK
Sbjct: 21289 PILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSK 21343



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 79/284 (27%), Positives = 106/284 (37%), Gaps = 39/284 (13%)

Query: 429   GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
             G  V +   VF  P  T+SW +DG LL  +    IK+    +   LE+   +  D G+Y 
Sbjct: 19310 GTNVCLDATVFGKPMPTVSWKKDGTLLKPA--EGIKMAMQRNLCTLELFSVNRKDSGDYT 19367

Query: 489   CTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 547
              TA N  G +S    L   D P  P S+   + YS  A + ++ P   GG  I  Y  + 
Sbjct: 19368 ITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDK 19427

Query: 548   RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPET-----TYAVRLAALNGKGLGEISAASE 602
             R      W         A +   V I     E       Y  R+ A N  G+G+      
Sbjct: 19428 RETSRPNW---------AQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGD------ 19472

Query: 603   FKTQPVQGEPSAPKLE-GQMGEDGNSIKVNLIKQ----------DDGGSPIRHYLVRYRA 651
                 PV  EP+  K      G     +  N+ K           DDGGSPI  YL+  R 
Sbjct: 19473 ----PVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRE 19528

Query: 652   LSS-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 694
               +  W    R P     +    L    EYE  V A N+ G  K
Sbjct: 19529 TQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGK 19572



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 78/292 (26%), Positives = 129/292 (44%), Gaps = 20/292 (6%)

Query: 411   EVQYAPKLQGPVAVYTW----EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIY 466
             ++  AP++   VA+ T      G  V +       P  T++W +D + L S   +   I 
Sbjct: 27264 DILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSD--ARYSIE 27321

Query: 467   NTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA-DTPSSPSIDQVEPYS-ST 524
             NT S+S L +   + ND G Y  T  N +G+     + V+  DTP++    QV+  S  T
Sbjct: 27322 NTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGT 27381

Query: 525   AQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAV 584
               + +D P   GG PI+ Y  E R   +  W    +     S +    ++ L  +T +  
Sbjct: 27382 VTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFK----LIDLSEKTPFFF 27437

Query: 585   RLAALNGKGLGEISAASEFKTQPVQ-GEPSAPKLEGQMGED-GNSIKVNLIKQD-DGGSP 641
             R+ A N  G+GE        T+PV+  E  AP  +  M +    S+ ++  K D DGGS 
Sbjct: 27438 RVLAENEIGIGEPCET----TEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFDGGSV 27493

Query: 642   IRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 693
             I  Y+V  +    +      + S +  + +  L   +  E  V A+N++G S
Sbjct: 27494 ITEYVVERKGKGEQTWSHAGI-SKTCEIEVSQLKEQSVLEFRVFAKNEKGLS 27544



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 109/511 (21%), Positives = 201/511 (39%), Gaps = 80/511 (15%)

Query: 39   FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVV 98
            F+ +V GD    ++ W      +L  NQ     +      + L I +    D+G+Y+CV 
Sbjct: 8473 FIAKVGGDPIP-NVKWTKGKWRQL--NQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVA 8529

Query: 99   TGEDGSESEATVNVKIFQK-----------LMFKNAPTPQEFREGEDAVIVCDVVSSLPP 147
              E G E E+ VN+++ ++            M K  P  ++    E+ + + +++ ++ P
Sbjct: 8530 FNEHG-EIESNVNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLKNVDP 8588

Query: 148  TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
                K+     I   D R ++ +   L+    +  +E T+R E   + R E + K+ + +
Sbjct: 8589 KEYEKYARMYGIT--DFRGLLQAFELLK----QSQEEETHRLEIEEIERSERDEKEFEEL 8642

Query: 208  VNVPPTIQAR----------QNIVNATANLGQSVTLVCDAE-GFPEPTMSWTKDGEQIEQ 256
            V+    IQ R          ++I N T           D +  +PE  +SW K  E++E 
Sbjct: 8643 VSF---IQQRLSQTEPVTLIKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEP 8699

Query: 257  EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
             +  E  I   D   L +K     D+  Y  +     G   A+  L V       ++++ 
Sbjct: 8700 SDKFEISI-DGDRHTLRVKNCQLKDQGNYRLVC----GPHIASAKLTVIEPAWERHLQDV 8754

Query: 317  TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHAR 376
            T  E  +  T+TC+ S   +P++             K+ W R  +     G        +
Sbjct: 8755 TLKE-GQTCTMTCQFS---VPNV-------------KSEWFRNGRILKPQGRHKTEVEHK 8797

Query: 377  VSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLE---VQYAPKLQGPVAVYTWEGNQVN 433
            V  LT+  ++  D G+Y C   +   + S  + +E   +Q+  ++Q    +   E     
Sbjct: 8798 VHKLTIADVRAEDQGQYTCKYEDL--ETSAELRIEAEPIQFTKRIQN---IVVSEHQSAT 8852

Query: 434  ITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYL---EVTPDSENDF------ 484
              CEV ++  A ++W++    L  S   N +  N     Y+    VTPD E  +      
Sbjct: 8853 FECEV-SFDDAIVTWYKGPTELTESQKYNFR--NDGRCHYMTIHNVTPDDEGVYSVIARL 8909

Query: 485  ---GNYNCTAVNRIGQESLEFILVQADTPSS 512
               G    TA   +  + ++  L   D P S
Sbjct: 8910 EPRGEARSTAELYLTTKEIKLELKPPDIPDS 8940



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 111/530 (20%), Positives = 190/530 (35%), Gaps = 82/530 (15%)

Query: 50    KDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSE---- 105
             K+++W+  +G+KL  N       ++ D +  L I N    D G Y C ++GE G+     
Sbjct: 32747 KEVTWYK-DGKKLKENGH-FQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNL 32804

Query: 106   ---------------------------SEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
                                        +E+TV  K   K     +  P      +D  + 
Sbjct: 32805 QFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVS 32864

Query: 139   CDVVSSLP--------PTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRC 189
              D V+           PT IW   G+ +      +       + L+I     +D G Y C
Sbjct: 32865 SDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTC 32924

Query: 190   EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAE------GFPEP 243
               +  A G ++    ++ +      +A++     T+ +      V   E         E 
Sbjct: 32925 TVKNSA-GSVS-SSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEI 32982

Query: 244   TMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLK 303
              MS  K  E++  +E+  K + S++  +     ++K+   E I      + E      +K
Sbjct: 32983 KMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIK 33042

Query: 304   VFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQE 363
              F+          T M + E   L  +A+      + W  +   +++ E+  +      +
Sbjct: 33043 AFS----------TQMSINEGQRLVLKANIAGATDVKWVLNGVELTNSEEYRYGVSGSDQ 33092

Query: 364   TLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG----QDSQSMYLEVQYAPK-L 418
             TL               T+K   + D G   C +    G    Q   ++  E+  AP  +
Sbjct: 33093 TL---------------TIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFI 33137

Query: 419   QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTP 478
               P +    EG  V  TCE+   PS  I WF++   LP S  SN+ I  + +   LE+  
Sbjct: 33138 SQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNN--LPISISSNVSISRSRNVYSLEIRN 33195

Query: 479   DSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQ 528
              S +D G Y   A N  GQ S    L+       PS + V   S    +Q
Sbjct: 33196 ASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQ 33245



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 75/282 (26%), Positives = 112/282 (39%), Gaps = 13/282 (4%)

Query: 438   VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 497
             +   P    SW + G+ +  S+ + I   +TP++S L +   +  D G Y  TA N  G 
Sbjct: 20403 ILGKPLPKSSWSKAGKDIRPSDITQIT--STPTSSMLTIKYATRKDAGEYTITATNPFGT 20460

Query: 498   ESLEFILVQADTPSSPSIDQVEPYSS-TAQVQFDEPEATGGVPILKYKAEWRAVGEEVWH 556
             +     +   D P  P   ++   S+  A + +  P   GG PI  Y  E R     +W 
Sbjct: 20461 KVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWT 20520

Query: 557   SKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPK 616
                 D +         I G      Y  R++A+N  G GE   +   K     G P  P+
Sbjct: 20521 VVSEDIQSCRHVATKLIQG----NEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPE 20576

Query: 617   LEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSL 674
                      N+  V+  +  DDGGS I  Y V  R   S  W   I+ P       +  L
Sbjct: 20577 KPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGL 20636

Query: 675   DWNAEYEVYVVAENQQG---KSKAAHFV-FRTSAQPTAIPAN 712
                + YE  V AEN+ G    S+A+  V  + +A P   P+N
Sbjct: 20637 QEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSN 20678



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 102/444 (22%), Positives = 169/444 (38%), Gaps = 43/444 (9%)

Query: 271   QLTIKKVDKNDEAEYICIAENKAG-----EQDATIHLKVFA--KPKITYVENQTAMELEE 323
             Q TI  + +  E E+   AEN+ G         +I  K+ +   P I         +L E
Sbjct: 30489 QFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGE 30548

Query: 324   QVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLK 383
                L+C+  G P+P I W    + +    K   +               S  R  +LT+ 
Sbjct: 30549 AAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMS---------------SDGRTHTLTVM 30593

Query: 384   SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAV----YTWEGNQVNITCEVF 439
             + +  D G Y C A+N +G+   S  L +Q  P+      +    Y   G+ + +     
Sbjct: 30594 TEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYI 30653

Query: 440   AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEV-TPDSENDFGNYNCTAVNRIGQ- 497
               P   ++WF   +LL   N  NI I NT   ++L +     +   G Y     N  G  
Sbjct: 30654 GRPVPAMTWFHGQKLL--QNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTV 30711

Query: 498   ESLEFILVQ--ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW 555
             +++  + +Q   D P+ P + +     ++A + +  P   GG  I  Y  E     E   
Sbjct: 30712 DAILDVEIQDKPDKPTGPIVIEA-LLKNSAVISWKPPADDGGSWITNYVVEKCEAKE--- 30767

Query: 556   HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLG---EISAASEFKTQ-PVQGE 611
              ++W     A       IV L     Y  R++A N  G+    E+S+    K+     G 
Sbjct: 30768 GAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGA 30827

Query: 612   PSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIR-HYLVRYRALSSEWKPEIRLPSGSDHVM 670
             P  P +     +  + +        DGG+ IR +YL +     ++W              
Sbjct: 30828 PGKPTITAVTKD--SCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFS 30885

Query: 671   LKSLDWNAEYEVYVVAENQQGKSK 694
             +K+L    EYE  V  EN  G+S+
Sbjct: 30886 VKNLIEGLEYEFRVKCENLGGESE 30909



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 117/500 (23%), Positives = 194/500 (38%), Gaps = 61/500 (12%)

Query: 234   VCDAEGFPEP--------TMSWTKD----GEQIEQ------EEDDEKYIF-----SDDSS 270
             V DA G PEP        T++W +     G +I+Q      E+   +++          +
Sbjct: 28151 VPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISET 28210

Query: 271   QLTIKKVDKNDEAEYICIAENKAGEQDAT-IHLKVFAKPKITYVENQTAMELEEQVTLTC 329
             +  +  + + +E E+  +AEN AG   A+ I   +  +  +      T +++ +    T 
Sbjct: 28211 RFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTV 28270

Query: 330   EASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTD 389
                     S+ W     +   E         K +  D H V       +  T+  +Q  +
Sbjct: 28271 --------SLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGE 28322

Query: 390   AGEYICTASNTIGQ-DSQSMYLEVQYAPKLQGPVAVYTWEGNQVNI-----TCEVF-AY- 441
               ++  +A N  G+ DS  +   ++   +L  P         Q ++     +  +F AY 
Sbjct: 28323 EYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQ 28382

Query: 442   --PSATISWFRDGQLLPSSNYS-NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 498
               P+ T  W +     P SN S    I+ T S S L V   + ND G Y  T  N  G +
Sbjct: 28383 GRPTPTAVWSK-----PDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSK 28437

Query: 499   SLEFILVQADTPSSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHS 557
             S+ F +   DTP  P  I   +    +A + +D P   GG  I  Y  E R    E    
Sbjct: 28438 SITFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKR----EASRR 28493

Query: 558   KWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQG--EPSAP 615
              W    E     I  +  L     Y  R++A+N  G+GE     E    P+    +P+ P
Sbjct: 28494 SWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPE----PIVATEQPAPP 28549

Query: 616   KLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSL 674
             +    +    +S  +  +K D DGGS I  YL+  R   S++  E          + + +
Sbjct: 28550 RRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLV 28609

Query: 675   DWNAEYEVYVVAENQQGKSK 694
             +   EYE  V A+N  G S+
Sbjct: 28610 E-KTEYEFRVKAKNDAGYSE 28628



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 104/452 (23%), Positives = 173/452 (38%), Gaps = 55/452 (12%)

Query: 271   QLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKIT-YVENQTAMELEE--QV 325
             Q T++ + +  E E+   A N AG  +  AT+      +P +   ++ +  ME+EE   V
Sbjct: 16075 QFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNV 16134

Query: 326   TLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETL--DGHMVVRSHARVSSLTLK 383
              +  +  G P P++TW           KA   +P+ +E +  D H+         +L + 
Sbjct: 16135 NIVAKIKGVPFPTLTWF----------KAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIP 16184

Query: 384   SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYP 442
               + +D G Y  TA N +G  S+ M L V   P    GP+   +   +Q+          
Sbjct: 16185 QSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQM---------- 16234

Query: 443   SATISWF--RDGQLLPSSNY----------SNIKIYNTPSASYLEVTPDSENDFGNYNCT 490
               T+SWF  +D      +NY          + + + + P      +    E     +   
Sbjct: 16235 --TLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIM 16292

Query: 491   AVNRIG--------QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 542
             A N+ G         E+   +      P  P++  V   S T  V ++EPE  GG P+  
Sbjct: 16293 AQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTRNSMT--VNWEEPEYDGGSPVTG 16350

Query: 543   YKAEWRAVGEEVWHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAAS 601
             Y  E +    + W     D  +A   G+   + GL   + Y  R+ A+N  G+G  S  S
Sbjct: 16351 YWLEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPS 16410

Query: 602   EFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRAL-SSEWKPE 659
             +  T      P  P          +S  +       DGGS +  Y+V Y+     EW+  
Sbjct: 16411 DPATARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKG 16470

Query: 660   IRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 691
                      +++  L   A Y+  V A N  G
Sbjct: 16471 KDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAG 16502



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 87/358 (24%), Positives = 136/358 (37%), Gaps = 31/358 (8%)

Query: 252   EQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKIT 311
             E+I +     K +      +  +K  +   E+E+  I+E    + D  I    F +    
Sbjct: 30877 EEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEEL-- 30934

Query: 312   YVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVV 371
                    +  +   TL C+ +G P P + W    + I     A   +   QE   G+   
Sbjct: 30935 ---RNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEII----ADGLKYRIQEFKGGY--- 30984

Query: 372   RSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK------LQGPVAVY 425
                     L + S+   DA  Y   A+N  G  S +  LEV+   K      L+G  AV+
Sbjct: 30985 ------HQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVH 31038

Query: 426   TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFG 485
                G  V+I       P   I+W +   L+ ++ +  + I      S +        D G
Sbjct: 31039 ALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQV-IVTRSFTSLVFPNGVERKDAG 31097

Query: 486   NYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGVPILKYK 544
              Y   A NR G +     L  AD P  P   +V   S  +  + + EP + GG  I  Y 
Sbjct: 31098 FYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYI 31157

Query: 545   AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 602
              E  A   E    +W    +A  E   T++ L  +T+Y  R+ A N  GL + S  SE
Sbjct: 31158 VEKCATTAE----RWLRVGQA-RETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSE 31210



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 73/286 (25%), Positives = 116/286 (40%), Gaps = 20/286 (6%)

Query: 428   EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 487
             EG +++I     A P  T+SW +DG+ + +S+   +K  N   +++LEV      D G Y
Sbjct: 14400 EGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMK--NDHISAHLEVPKSVRADAGIY 14457

Query: 488   NCTAVNRIGQESLEFILVQADTPSS-PSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAE 546
               T  N++G  +    +     P     I   +   S+ ++ ++ PE  GG PIL Y  E
Sbjct: 14458 TITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLE 14517

Query: 547   WRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQ 606
              R  G   +        + S     T+  L P   Y  R+ A+N  G GE          
Sbjct: 14518 RREAGRRTYIPVMSGENKLSW----TVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIA 14573

Query: 607   PVQGEPSAPKLEGQMGEDGNSIKVNLIKQD--DGGSPIRHYLVRYRALSSEWKPEIRLPS 664
                 +P  P ++ ++            K    DGGS I  Y++   A     K E R   
Sbjct: 14574 QDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIA-----KGEERWKR 14628

Query: 665   GSDHVM------LKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSA 704
              ++H++       K L+   EY+  V AEN  G S+ +     T A
Sbjct: 14629 CNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKA 14674



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 116/497 (23%), Positives = 186/497 (37%), Gaps = 73/497 (14%)

Query: 34   GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSST-LTIYNANIDDAG 92
            G S  F CQV G+ K     ++  +G  LT    R  V +N  +    L I     DDAG
Sbjct: 1096 GGSVVFGCQVGGNPKPH--VYWKKSGVPLTTGY-RYKVSYNKQTGECKLVISMTFADDAG 1152

Query: 93   IYKCVVTGEDGS---------ESEATVNVKIFQKLMFKNAPTP--QEFREGEDA----VI 137
             Y  VV  + G          E++  + +K  Q+++++   T   QE + GE A      
Sbjct: 1153 EYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYS 1212

Query: 138  VCDVVSSLPPTIIWKHKGRDVILKK----DVRFIVLSNNY-----LQIRGIKKTDEGTYR 188
              +        +I K   +D ++ +    D  F + S        ++ R IK T E    
Sbjct: 1213 EYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLE 1272

Query: 189  CEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWT 248
             +G      E    DI     V     +R  I N     G  VT  C   G+P P ++W 
Sbjct: 1273 EDGE-----EKMAVDISESEAVESGFDSR--IKNYRILEGMGVTFHCKMSGYPLPKIAWY 1325

Query: 249  KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
            KDG++I+  E  +     D  + L I  V   DE  Y   A N  G  +A    K++ +P
Sbjct: 1326 KDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKG--NAICSGKLYVEP 1383

Query: 309  KITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGH 368
                                      P+ + T+      I + E  S  R     ++   
Sbjct: 1384 ------------------------AAPLGAPTY------IPTLEPVSRIRSLSPRSVSRS 1413

Query: 369  MVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTW 427
             +  S AR+S   +   + + A      +     +++    LE  Y P  +  PV+    
Sbjct: 1414 PIRMSPARMSPARMSPARMSPAR----MSPGRRLEETDESQLERLYKPVFVLKPVSFKCL 1469

Query: 428  EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 487
            EG       +V   P     WF DGQ +  ++Y++  +        L + P + +D G +
Sbjct: 1470 EGQTARFDLKVVGRPMPETFWFHDGQQI-VNDYTHKVVIKEDGTQSLIIVPATPSDSGEW 1528

Query: 488  NCTAVNRIGQESLEFIL 504
               A NR G+ S+  IL
Sbjct: 1529 TVVAQNRAGRSSISVIL 1545



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 67/305 (21%), Positives = 125/305 (40%), Gaps = 33/305 (10%)

Query: 228   GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD--KNDEAEY 285
             GQ+   + + +  P   + W  +G ++++     K  +++ S  LT++ +D   +D   Y
Sbjct: 32388 GQNTRFILNVQSKPTAEVKWYHNGVELQESS---KIHYTNTSGVLTLEILDCHTDDSGTY 32444

Query: 286   ICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTST 345
               +  N  GE      L V      TY   +   E+   V           P +T RT  
Sbjct: 32445 RAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSV----------FPELT-RTEA 32493

Query: 346   RNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA--SNTIGQ 403
               +SS +K S     + E       V+S    +  +L S +++ + E    A    ++ +
Sbjct: 32494 YAVSSFKKTS-----EMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEE 32548

Query: 404   DSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSN 462
              S +  ++   A + L  P ++  +EG     +C+    P  T++W R GQ+L +S  + 
Sbjct: 32549 KSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTS--AR 32606

Query: 463   IKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL-------VQADTPSSPSI 515
              ++  T   S  E++    +D GNY+    N  G++  EF L        +    S P +
Sbjct: 32607 HQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRV 32666

Query: 516   DQVEP 520
                EP
Sbjct: 32667 KSPEP 32671



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 111/563 (19%), Positives = 213/563 (37%), Gaps = 39/563 (6%)

Query: 147   PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQV 206
             P + W+  G D +++K    +V +  +L I    + D G Y       A  +  F +++V
Sbjct: 18636 PKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRV 18695

Query: 207   IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFS 266
             +    P    + + V  T+         C     P      ++    I ++ + ++  +S
Sbjct: 18696 LDTPGPVSDLKVSDVTKTS---------CHVSWAPPENDGGSQVTHYIVEKREADRKTWS 18746

Query: 267   DDSSQLT-----IKKVDKNDEAEYICIAENKAGEQDAT-IHLKVFAKPKITYVENQTAME 320
               + ++      +  +   +E  +   A N+ G    T +   V A   ++  +    +E
Sbjct: 18747 TVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLE 18806

Query: 321   LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSL 380
             + E    +         ++ W    R+  ++     T   ++E         S  +  SL
Sbjct: 18807 VTEMTKNSA--------TLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSL 18858

Query: 381   TLKSIQYTDAGEYICTASNTIG----QDSQSMY--LEVQYAPKLQGPVAVYTWEGNQVNI 434
              +  ++     ++   A N +G    ++++ +Y   E    PK+  P  +    G ++ I
Sbjct: 18859 VVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRI 18918

Query: 435   TCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNR 494
                V+  P  T  W +    + +S  S++ ++   S+S L +   +  D G Y+ TA N 
Sbjct: 18919 EAHVYGKPHPTCKWKKGEDEVVTS--SHLAVHKADSSSILIIKDVTRKDSGYYSLTAENS 18976

Query: 495   IGQES--LEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGE 552
              G ++  ++ +++ A  P  P  D  +  +    + +  P   GG  I  Y  E      
Sbjct: 18977 SGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKC---- 19032

Query: 553   EVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEP 612
             +V    W  A  +  +    +  L P   Y  R+ A N  G+ E   + +   Q   G P
Sbjct: 19033 DVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVP 19092

Query: 613   SAPKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVM 670
             S PK       + + I V   + D DGGSPI  YL+  +  +S  W         S    
Sbjct: 19093 SEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYP 19152

Query: 671   LKSLDWNAEYEVYVVAENQQGKS 693
                L    EY   + A N+ G S
Sbjct: 19153 CAGLVEGLEYSFRIYALNKAGSS 19175



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 97/419 (23%), Positives = 164/419 (39%), Gaps = 55/419 (13%)

Query: 228   GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
             G  + L    +G P P   WTK+G+ I +         S+  ++L IK+ D+ D   Y  
Sbjct: 30151 GGVIRLTIPIKGKPFPICKWTKEGQDISKR---AMIATSETHTELVIKEADRGDSGTYDL 30207

Query: 288   IAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347
             + ENK G++   I ++V   P       +  +E ++    +          ++WR    +
Sbjct: 30208 VLENKCGKKAVYIKVRVIGSPN----SPEGPLEYDDIQVRSVR--------VSWRPPADD 30255

Query: 348   ISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS 407
                 +   +    ++        + S  R +SL +K ++      +  +A N  G  S+ 
Sbjct: 30256 -GGADILGYILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFG-ISKP 30313

Query: 408   MYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFR---DGQLLPSSNYSNI 463
             +  E    PK    P    +     +++T       S ++SW R   DG    +  Y   
Sbjct: 30314 LKSEEPVTPKTPLNPPEPPSNPPEVLDVT-----KSSVSLSWSRPKDDGGSRVTGYYIER 30368

Query: 464   KIYNTP----------SASYLEVT---PDSENDFGNYNCTAVNRIG----QESLEFILVQ 506
             K  +T           + +   VT   PD+E  F      A N +G      + E ++ +
Sbjct: 30369 KETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQF---RIIAQNDVGLSETSPASEPVVCK 30425

Query: 507   --ADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 563
                D PS P  ++ +     +  +Q+++PE  GG  IL Y  E+R  G+  W       K
Sbjct: 30426 DPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKK---SNK 30482

Query: 564   EASMEGIVTIVGLKPETTYAVRLAALNGKGLGE-ISAASEFKTQPVQGEPSAPKLEGQM 621
             E   +   TI GL   T Y  R+ A N  GL      A   KT+   GE  AP +  +M
Sbjct: 30483 ERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGE--APGIRKEM 30539



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 70/295 (23%), Positives = 116/295 (39%), Gaps = 23/295 (7%)

Query: 428   EGNQVNITCEVFAYPSATISWFRDGQLLPSSNY-----SNIKIYNTPSASYLEVTPDSEN 482
             EG  VNI  ++   P  T++WF+     P +       +++          L +     +
Sbjct: 16130 EGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRS 16189

Query: 483   DFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVP 539
             D G Y  TAVN +G  S E  L     P  P +  ++  S +A    + +  P+  GG  
Sbjct: 16190 DTGLYTITAVNNLGTASKEMRLNVLGRP-GPPVGPIKFESVSADQMTLSWFPPKDDGGSK 16248

Query: 540   ILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISA 599
             I  Y  E R    + W     + KE +     TI  L     Y  R+ A N  G+GE   
Sbjct: 16249 ITNYVIEKREANRKTWVHVSSEPKECT----YTIPKLLEGHEYVFRIMAQNKYGIGEPLD 16304

Query: 600   ASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYR-ALSSEWK 657
             +     + +   P AP          NS+ VN  + + DGGSP+  Y +  +   S  WK
Sbjct: 16305 SEPETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWK 16364

Query: 658   PEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 712
                R P       +K++     Y+V  + E    + +  + +      P ++P++
Sbjct: 16365 RVNRDP-------IKAMTLGVSYKVTGLIEGSDYQFR-VYAINAAGVGPASLPSD 16411



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 65/271 (23%), Positives = 103/271 (38%), Gaps = 13/271 (4%)

Query: 429   GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
             G  V     +   P  T  W  DG  + +  +  ++  N   +S L +      D G Y 
Sbjct: 17525 GTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNF--SSVLTIKNCLRRDTGEYQ 17582

Query: 489   CTAVNRIGQESLEFILVQADTPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKYK 544
              T  N  G +++   L   D P  P+    I  V P   T  + +  P+  GG P++ Y 
Sbjct: 17583 ITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMT--ISWQPPKDDGGSPVINYI 17640

Query: 545   AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 604
              E +   ++ W          S +  + I  L+    Y  R+ A N  G+G    ++   
Sbjct: 17641 VEKQDTRKDTWGV----VSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTV 17696

Query: 605   TQPVQGEPSAPKLEGQMGEDGNSIKVN-LIKQDDGGSPIRHYLVRYRALSSEWKPEIRLP 663
              +     PS P          N+  V+  + + DGGSPI  Y +  R ++ +W    + P
Sbjct: 17697 AKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTP 17756

Query: 664   SGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 694
                    +  L     YE  V AEN  G SK
Sbjct: 17757 IADLKFRVTGLYEGNTYEFRVFAENLAGLSK 17787



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 135/639 (21%), Positives = 238/639 (37%), Gaps = 83/639 (12%)

Query: 49    DKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEA 108
             + ++ W    G  +  ++ +I V     S + L I N    D+G Y   +    GS++ A
Sbjct: 25136 EPEVKWEKAEG--ILTDRAQIEVT---SSFTMLVIDNVTRFDSGRYNLTLENNSGSKT-A 25189

Query: 109   TVNVKIFQKLMFKNAPTPQEFRE-GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVR-- 165
              VNV++       +AP     RE  +D+V     +S  PP I    K  + I++K     
Sbjct: 25190 FVNVRVLDS---PSAPVNLTIREVKKDSV----TLSWEPPLIDGGAKITNYIVEKRETTR 25242

Query: 166   --FIVLSNNYLQIR-GIKKTDEGTYRCEGRILARGEINF-----KDIQVIVNVPPTIQAR 217
               +  ++NN  +    I+   EG      R+LA  E            V V+ PP    R
Sbjct: 25243 KAYATITNNCTKTTFRIENLQEGC-SYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGR 25301

Query: 218   QNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE-QEEDDEKYIFSDDSSQL--TI 274
               +V+ T N         +++G  + T      G  +E Q +  EK+        L  TI
Sbjct: 25302 VTLVDVTRNTATIKWEKPESDGGSKIT------GYVVEMQTKGSEKWSTCTQVKTLEATI 25355

Query: 275   KKVDKNDEAEYICIAENKAGEQDA------TIHLKVFAKPKITYVENQTAMELEEQVTLT 328
               +   +E  +   A N+ G  D        I   +  KP +    +   ++  EQ+ + 
Sbjct: 25356 SGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKID 25415

Query: 329   CEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYT 388
                 G P  ++ WR   + +    + +               V S   V+SL++K     
Sbjct: 25416 VPFKGRPQATVNWRKDGQTLKETTRVN---------------VSSSKTVTSLSIKEASKE 25460

Query: 389   DAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAV---------YTWEGNQVNITCEVF 439
             D G Y    SN+ G  +  + + V   P   GP+ +          +W   + +  C++ 
Sbjct: 25461 DVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQIS 25520

Query: 440   AY-----PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNR 494
              Y      + + +W    Q +     ++IKI    + S  +    +EN +G  + +  + 
Sbjct: 25521 NYIVEKKETTSTTWHIVSQAVAR---TSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSA 25577

Query: 495   IGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEV 554
             +     E+       P +P +  V    ST  V +  P   GG  ++ Y  E++     +
Sbjct: 25578 V---VAEYPFSPPGPPGTPKV--VHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSIL 25632

Query: 555   WHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSA 614
             W       K    +  + + GL     Y  R+ A N  G+G+ S + E    P +     
Sbjct: 25633 WSKA---NKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCE--PVPARDPCDP 25687

Query: 615   PKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRAL 652
             P           S+ +   K   DGG+ I  Y+V  R L
Sbjct: 25688 PGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERREL 25726



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 70/274 (25%), Positives = 108/274 (39%), Gaps = 13/274 (4%)

Query: 429   GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
             G  + I   V   P   ++WF+DG  +      N++I +   ++ L V   + +  G Y 
Sbjct: 27973 GESLRIKALVQGRPVPRVTWFKDG--VEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYT 28030

Query: 489   CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKA 545
               A N  G    E  +   DTP    +  +   + T +   + +D P   G  PI  Y  
Sbjct: 28031 VEAKNASGSAKAEIKVKVQDTPGKV-VGPIRFTNITGEKMTLWWDAPLNDGCAPITHYII 28089

Query: 546   EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKT 605
             E R      W       +  S   I  I G      Y  R++A+N  G+G    +     
Sbjct: 28090 EKRETSRLAWALIEDKCEAQSYTAIKLING----NEYQFRVSAVNKFGVGRPLDSDPVVA 28145

Query: 606   QPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLV-RYRALSSEWKPEI-RL 662
             Q     P AP +       GNSI +   + + DGGS I+ Y++ R    S+ W   I + 
Sbjct: 28146 QIQYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKR 28205

Query: 663   PSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 696
             P       +  L    EYE +V+AEN  G   A+
Sbjct: 28206 PISETRFKVTGLTEGNEYEFHVMAENAAGVGPAS 28239



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 116/510 (22%), Positives = 191/510 (37%), Gaps = 73/510 (14%)

Query: 235   CDAEGFPEP--------TMSWTK---DGEQIEQEEDDEKYIFSDD-----------SSQL 272
             CD  G PEP        T+ WTK   DG  +      EK    D             +Q 
Sbjct: 23521 CDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQF 23580

Query: 273   TIKKVDKNDEAEYICIAENKAGE-------------QDATIHLKVFAKPKITYVENQTAM 319
             T+  + ++   E+  IA+N AG              +D     ++   PK     +   +
Sbjct: 23581 TVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKF---RDTIVV 23637

Query: 320   ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS 379
                E   L  +  G P+P+I W    + I    +       K       ++V+   R+  
Sbjct: 23638 NAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEI----KNTDFKALLIVKDAIRI-- 23691

Query: 380   LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEV 438
                      D G+YI  ASN  G  S  + ++V   P   +GPV V      + ++T   
Sbjct: 23692 ---------DGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSP 23742

Query: 439   FAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-Q 497
                   +       +   +S  +   + +    + L+VT   E +   +   AVN+ G  
Sbjct: 23743 PLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVG 23802

Query: 498   ESLEFILVQADTP-----SSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGE 552
             E LE   V    P        S++       +  V ++ P++ GG  I+ Y  E R    
Sbjct: 23803 EPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKR---- 23858

Query: 553   EVWHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAAS-EFKTQPVQG 610
             +    +W    +  +  + + + GL  +  Y  R++A N  G+GE S A+  +K      
Sbjct: 23859 DRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVF 23918

Query: 611   EPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRY-RALSSEWKPEIRLPSGSDH 668
             +P  P     +    NSI +   K   DGGS I  Y+V   +A   EW  +I  P     
Sbjct: 23919 KPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEW--QIVTPQTGLR 23976

Query: 669   VM---LKSLDWNAEYEVYVVAENQQGKSKA 695
             V    +  L  + EY++ V A N+ G  +A
Sbjct: 23977 VTRFEISKLTEHQEYKIRVCALNKVGLGEA 24006



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 97/405 (23%), Positives = 158/405 (39%), Gaps = 68/405 (16%)

Query: 323   EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTL 382
             E   L  +  G PIP + W    + +  EE A+             M ++S  + ++L +
Sbjct: 24723 ETFVLEADIRGKPIPDVVWSKDGKEL--EETAA------------RMEIKSTIQKTTLVV 24768

Query: 383   KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP-KLQGPVAV---------YTW----E 428
             K    TD G+YI   SN  G  S  + ++V   P   +GP+ V           W    +
Sbjct: 24769 KDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQ 24828

Query: 429   GNQVNITCEVF-AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 487
                 NI+  +     ++ +SW +    + + NY   K+   P   Y+            +
Sbjct: 24829 DGGANISHYIIEKRETSRLSWTQVSTEVQALNYKVTKL--LPGNEYI------------F 24874

Query: 488   NCTAVNRIG-QESLEFILVQA----DTPSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPIL 541
                AVN+ G  E LE   V A      P  PS  +V   +  +  V +  P   GG  I 
Sbjct: 24875 RVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIE 24934

Query: 542   KYKAEWRAVGEEVWHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAA 600
              Y  E R    +    +W    + ++  + + + GL    +Y  R+AA N  G+GE S  
Sbjct: 24935 GYILEKR----DKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEP 24990

Query: 601   SEF----KTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQD---DGGSPIRHYLVRYRALS 653
             S F          G PS PK+      D +   V+L       DGG+P++ Y+V  +  +
Sbjct: 24991 SVFYRACDALYPPGPPSNPKV-----TDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAA 25045

Query: 654   SEWKPEIRLPSG--SDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 696
             ++       P+G       +  L  N EY   + A N +G  + A
Sbjct: 25046 ADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVGEPA 25090



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 88/423 (20%), Positives = 164/423 (38%), Gaps = 45/423 (10%)

Query: 95    KCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHK 154
             K +V  E    S+A+  V+   ++  K   T     EG+  V+  ++  +    + W   
Sbjct: 33018 KSIVHEEITKTSQASEEVRTHAEI--KAFSTQMSINEGQRLVLKANIAGATD--VKWVLN 33073

Query: 155   GRDVILKKDVRFIVL-SNNYLQIRGIKKTDEGTYRC-----EGRILARGEINFK----DI 204
             G ++   ++ R+ V  S+  L I+     DEG   C     EG +  + ++       D 
Sbjct: 33074 GVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDA 33133

Query: 205   QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264
                ++ P +    QNI     N GQ+V   C+  G P P + W K+   I    +     
Sbjct: 33134 PAFISQPRS----QNI-----NEGQNVLFTCEISGEPSPEIEWFKNNLPISISSN-VSIS 33183

Query: 265   FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQ 324
              S +   L I+    +D  +Y   A+N  G+  AT  L V   P +     +  +     
Sbjct: 33184 RSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL--PLVEEPSREVVLRTSGD 33241

Query: 325   VTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKS 384
              +L    S           S +  +S+++AS++           M     A +S+ ++ S
Sbjct: 33242 TSLQGSFSSQ---------SVQMSASKQEASFSSFSSSSA--SSMTEMKFASMSAQSMSS 33290

Query: 385   IQYT----DAGEYICTASNTIGQDSQSMYLEVQYA---PKLQG-PVAVYTWEGNQVNITC 436
             +Q +     +  ++  ++ T  + S S  L+       PK++  P  +   EG  + + C
Sbjct: 33291 MQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVAC 33350

Query: 437   EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 496
                  P+  ++W   G+ + S       I NT   + L +    + D G Y  +  N  G
Sbjct: 33351 AFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFG 33410

Query: 497   QES 499
              +S
Sbjct: 33411 SDS 33413



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 89/338 (26%), Positives = 137/338 (40%), Gaps = 56/338 (16%)

Query: 333   GDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGE 392
             G P+P+  W T    I ++E               H  V +    S LT+K+    D GE
Sbjct: 17536 GVPVPTAKWTTDGSEIKTDE---------------HYTVETDNFSSVLTIKNCLRRDTGE 17580

Query: 393   YICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF--R 450
             Y  T SN  G  + +++L V   P   GP    T   N +++T E       TISW   +
Sbjct: 17581 YQITVSNAAGSKTVAVHLTVLDVP---GPP---TGPINILDVTPE-----HMTISWQPPK 17629

Query: 451   DGQLLPSSNYSNIK----------IYNTPSASYLEVTPDSENDFGNYNCTAVNRIG---- 496
             D    P  NY   K          + +  S + L++    +     +   A N+IG    
Sbjct: 17630 DDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPP 17689

Query: 497   QESLEFILVQADTPSSPSIDQV--EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEV 554
              +S   +     +P SP    V  +   + A V +  P++ GG PI  Y  E R V    
Sbjct: 17690 LDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREV---- 17745

Query: 555   WHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASE--FKTQPVQ-- 609
                KW    +  +  +   + GL    TY  R+ A N  GL + S +S+     +P++  
Sbjct: 17746 -TGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPP 17804

Query: 610   GEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLV 647
             G P  PKL+ +  E  + +    +   DGGSPI  Y+V
Sbjct: 17805 GPPINPKLKDKSRETADLVWTKPL--SDGGSPILGYVV 17840



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 131/558 (23%), Positives = 212/558 (37%), Gaps = 80/558 (14%)

Query: 190   EGRILARGEINFKDI-QVIVNVPPTIQARQNI--VNATANLGQSVTLVCDAEGFPEPTMS 246
             +  +LA  E  F+   +  V V PTI+ +  I  +N     G+   L    +G     + 
Sbjct: 18061 KANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLK 18120

Query: 247   WTK---DG----------EQIEQEEDDEK-YIFSDDSSQLTIKKVDKNDEAEYICIAENK 292
             W +   DG           +++  +D E+ +  S   +   + +  +N   E+    +N+
Sbjct: 18121 WRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNE 18180

Query: 293   AGEQDATIHLKVFAKPKITY------VENQTAMELEEQVTLTCEASGDPIPSITWRTSTR 346
              GE D     +V  K  +        +     ++  + + L     G P P + W     
Sbjct: 18181 GGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWT---- 18236

Query: 347   NISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQ 406
                 ++    TR  + +       + + A  S  +L   + +D G+Y+ TA+NT G  S 
Sbjct: 18237 --KDKDATDLTRSPRVK-------IDTRADSSKFSLTKAKRSDGGKYVVTATNTAG--SF 18285

Query: 407   SMYLEVQYAPKLQGPV------------AVYTWEGNQVNITCEVFAYPSATISWFRDGQL 454
               Y  V    K  GPV                W+  + +  CE+  Y        R    
Sbjct: 18286 VAYATVNVLDK-PGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNYILEKCETKR---- 18340

Query: 455   LPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ----ESLEFIL-VQADT 509
             +  S YS   +  TP  +   +   +E  F      A N+IG     ES   I   + D 
Sbjct: 18341 MVWSTYSATVL--TPGTTVTRLIEGNEYIF---RVRAENKIGTGPPTESKPVIAKTKYDK 18395

Query: 510   PSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDA-KEASM 567
             P  P   +V   S     V ++ PE  GG  I  Y  E +    E   ++W    K A  
Sbjct: 18396 PGRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKK----EKHSTRWVPVNKSAIP 18451

Query: 568   EGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDG-N 626
             E  + +  L P+  Y  R+ A N  G+GE S  S         EP  P    ++ +   +
Sbjct: 18452 ERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKH 18511

Query: 627   SIKVNLIKQD-DGGSPIRHYLVRYRALSSEWKPEI---RLPSGSDHVM----LKSLDWNA 678
             SI +   K   DGG+PI  Y+V  R   ++  P+    R  + +  V     + SLD N 
Sbjct: 18512 SITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQ 18571

Query: 679   EYEVYVVAENQQGKSKAA 696
             EYE  V A+NQ G  + A
Sbjct: 18572 EYEFRVCAQNQVGIGRPA 18589



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 59/279 (21%), Positives = 115/279 (41%), Gaps = 14/279 (5%)

Query: 424   VYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEND 483
             ++  +G  + +T  +   P     W ++GQ +         I  + + + L +      D
Sbjct: 30146 IFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISK----RAMIATSETHTELVIKEADRGD 30201

Query: 484   FGNYNCTAVNRIGQESLEFILVQADTPSSPS--IDQVEPYSSTAQVQFDEPEATGGVPIL 541
              G Y+    N+ G++++   +    +P+SP   ++  +    + +V +  P   GG  IL
Sbjct: 30202 SGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADIL 30261

Query: 542   KYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAAS 601
              Y  E R V +  W++     +  S+     + GLK    Y  R++A N  G+ +   + 
Sbjct: 30262 GYILERREVPKAAWYTIDSRVRGTSL----VVKGLKENVEYHFRVSAENQFGISKPLKSE 30317

Query: 602   EFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLI---KQDDGGSPIR-HYLVRYRALSSEWK 657
             E  T      P  P        D     V+L     +DDGGS +  +Y+ R    + +W 
Sbjct: 30318 EPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWV 30377

Query: 658   PEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 696
                +    +    +  L  +AEY+  ++A+N  G S+ +
Sbjct: 30378 RHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETS 30416



 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 117/527 (22%), Positives = 194/527 (36%), Gaps = 76/527 (14%)

Query: 325   VTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKS 384
             + LT    G P P   W    ++IS                   M+  S    + L +K 
Sbjct: 30154 IRLTIPIKGKPFPICKWTKEGQDISKRA----------------MIATSETH-TELVIKE 30196

Query: 385   IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSA 444
                 D+G Y     N  G+  +++Y++V+       P     ++  QV      +  P+ 
Sbjct: 30197 ADRGDSGTYDLVLENKCGK--KAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPAD 30254

Query: 445   TISWFRDGQLLPSSNYSNIKIYNTPS---ASYLEVTPDSENDFGNYNCTAVNRIG----Q 497
                    G +L          Y   S    + L V    EN   ++  +A N+ G     
Sbjct: 30255 DGGADILGYILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPL 30314

Query: 498   ESLEFI-----LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGE 552
             +S E +     L   + PS+P  + ++   S+  + +  P+  GG  +  Y  E +    
Sbjct: 30315 KSEEPVTPKTPLNPPEPPSNPP-EVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETST 30373

Query: 553   EVW--HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE-FKTQPVQ 609
             + W  H+K           + T+ GL P+  Y  R+ A N  GL E S ASE    +   
Sbjct: 30374 DKWVRHNKTQITTT-----MYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPF 30428

Query: 610   GEPSAPKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALS-SEWKPEIRLPSGSD 667
              +PS P     +    +S+ +   K + DGG  I  Y V YR    S WK   +      
Sbjct: 30429 DKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDK 30488

Query: 668   HVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGI 727
                +  L    EYE  V AEN+ G S+          + TA+      TSG + G     
Sbjct: 30489 QFTIGGLLEATEYEFRVFAENETGLSR---------PRRTAMSIKTKLTSGEAPG----- 30534

Query: 728   LIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAK----GKDMEEGKAAFSKDE 783
                   +   + D+T     K G    ++  + G+  P  K    GK++ + +      +
Sbjct: 30535 ------IRKEMKDVT----TKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSD 30584

Query: 784   SKEPIVEVRTEEERTPNHDGGKHT--EPNETTPLTEPEKGPVEAKPE 828
              +   + V TEE+     D G +T    NE   +    K  ++A P+
Sbjct: 30585 GRTHTLTVMTEEQ----EDEGVYTCIATNEVGEVETSSKLLLQATPQ 30627



 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 86/358 (24%), Positives = 130/358 (36%), Gaps = 67/358 (18%)

Query: 189   CEGRILARGEINFKDIQVI-VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW 247
             C G I ++  ++   ++V  + + P       I++A    G  V  VC  E + + T   
Sbjct: 31545 CGGAIRSQKGVSVAKVKVASIEIGPV---SGQIMHAVGEEGGHVKYVCKIENYDQSTQVT 31601

Query: 248   TKDGEQIEQEEDDEKY--IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF 305
                G  + Q E+ EKY   + D  + L +K + K D+  Y C   N  GE  +  + ++F
Sbjct: 31602 WYFG--VRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSS--YAELF 31657

Query: 306   AK------------------------------PKITY-VENQTAMELEEQVTLTCEASGD 334
              K                              P+ T  + N+TA  + E V      +  
Sbjct: 31658 VKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAY-VGENVRFGVTITVH 31716

Query: 335   PIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 394
             P P +TW  S + I   +       +K+ T +      S   +  LT+ S+   D  EY 
Sbjct: 31717 PEPHVTWYKSGQKIKPGDN------DKKYTFE------SDKGLYQLTINSVTTDDDAEYT 31764

Query: 395   CTASNTIGQDSQSMYLEVQYAPKLQGPVA----------VYTWEGNQVNITCEVFAYPSA 444
               A N  G+DS    L V   P                     EG  V     V   P  
Sbjct: 31765 VVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPP 31824

Query: 445   TISWFRDGQLLPSSNYSNIKIYNTPSASY-LEVTPDSENDFGNYNCTAVNRIGQESLE 501
             T+ W +DGQ  P S   NI+I +     Y L +      D G Y  TA N  G  S +
Sbjct: 31825 TLKWEKDGQ--PLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQ 31880



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 103/416 (24%), Positives = 152/416 (36%), Gaps = 61/416 (14%)

Query: 210   VPPTIQARQNIVNA-TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
             VPP+++    ++       G +V       G P PT  WT DG +I+    DE Y    D
Sbjct: 17506 VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKT---DEHYTVETD 17562

Query: 269   --SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVT 326
               SS LTIK   + D  EY     N AG +   +HL V   P              E +T
Sbjct: 17563 NFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMT 17622

Query: 327   LTCEASGDP--IPSITWRTSTRNISSEEKASWTRPEKQET-LDGHMVVRSHARVSSLTLK 383
             ++ +   D    P I +                  EKQ+T  D   VV S +  + L + 
Sbjct: 17623 ISWQPPKDDGGSPVINYIV----------------EKQDTRKDTWGVVSSGSSKTKLKIP 17666

Query: 384   SIQYTDAGEYICTASNTIG----QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVF 439
              +Q      +   A N IG     DS     + +++P       V T      +IT    
Sbjct: 17667 HLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVT------DIT---- 17716

Query: 440   AYPSATISWF---RDGQLLPSSNYSN--------IKIYNTPSASY-LEVTPDSENDFGNY 487
                +AT+SW     DG    +  Y          +++  TP A     VT   E +   +
Sbjct: 17717 -ENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEF 17775

Query: 488   NCTAVNRIG--QESLEFILVQADTPSSPSIDQVEP-----YSSTAQVQFDEPEATGGVPI 540
                A N  G  + S     ++A  P  P    + P        TA + + +P + GG PI
Sbjct: 17776 RVFAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPI 17835

Query: 541   LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 596
             L Y  E +  G   W+    +  E   +    + GL     Y  R+ A N  G GE
Sbjct: 17836 LGYVVECQKPGTAQWNR--INKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGE 17889



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 98/440 (22%), Positives = 168/440 (38%), Gaps = 68/440 (15%)

Query: 30    EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
             E+S  ++   +C+V+    +  + W+  + E +   +  I     +     L I NA+++
Sbjct: 12473 EVSETDTIKLVCEVSKPGAE--VIWYKGDEEIIETGRYEILT---EGRKRILVIQNAHLE 12527

Query: 90    DAGIYKCVVTGEDGSESEATVNVKIFQKLM-FKNAPTPQEFREGEDAVIVCDVVSSLPPT 148
             DAG Y C +       S     VK+ +    F + P   E  EGE A  VC +     P 
Sbjct: 12528 DAGNYNCRLPS-----SRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFP- 12581

Query: 149   IIWKHKGR--------DVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200
             + WK   +        DVI     R +V+ +  LQ  G      G  R    +       
Sbjct: 12582 VQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTV----- 12636

Query: 201   FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDA--EGFPEPTMSWTKDGEQIEQEE 258
              + ++++V +  T    Q          Q V   C+   EG       W ++ E I    
Sbjct: 12637 IEKLRIVVPLKDTRVKEQ----------QEVVFNCEVNTEG---AKAKWFRNEEAIF--- 12680

Query: 259   DDEKYIF--SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
             D  KYI    D    L I+    +D+A Y     N  GE   +    +  +  +  VE  
Sbjct: 12681 DSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPL 12740

Query: 317   TAMELEEQVTLTCEASGDPIPSITW-RTSTRNISSEEKASWTRPEKQETLDGHMVVRSHA 375
               +E  E+ ++T            W + +  N++ +    WT+  ++   D  +  R   
Sbjct: 12741 KDIETMEKKSVTF-----------WCKVNRLNVTLK----WTKNGEEVPFDNRVSYRVDK 12785

Query: 376   RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK--LQGPVAVYTWEGNQVN 433
                 LT+K   + D GEYI TA    GQD     L +  AP   ++        E +   
Sbjct: 12786 YKHMLTIKDCGFPDEGEYIVTA----GQDKSVAELLIIEAPTEFVEHLEDQTVTEFDDAV 12841

Query: 434   ITCEVFAYPSATISWFRDGQ 453
              +C++ +   A + W+R+G+
Sbjct: 12842 FSCQL-SREKANVKWYRNGR 12860



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 114/564 (20%), Positives = 216/564 (38%), Gaps = 75/564 (13%)

Query: 41    CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
             C+V+   KD  + WF  +GE++ P+ +    +  D     L I  A++ D G Y C   G
Sbjct: 11684 CEVS---KDVPVKWFK-DGEEIVPSPKYS--IKADGLRRILKIKKADLKDKGEYVCDC-G 11736

Query: 101   EDGSESEATVNVKIF--QKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDV 158
              D +++  TV  ++   +K ++       E    E  +   DV         WK KG+ +
Sbjct: 11737 TDKTKANVTVEARLIKVEKPLYGVEVFVGETAHFEIELSEPDVHGQ------WKLKGQPL 11790

Query: 159   ILKKDVRFIVLSNNYLQIRG---IKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQ 215
                 D   I     ++ I     +  T E +++      A   +  K++ +I   P    
Sbjct: 11791 TASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSA-ANLKVKELPLIFITP---- 11845

Query: 216   ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQ-LTI 274
                 + +            C+    P+ T  W K  ++I    DD   +  D +   + I
Sbjct: 11846 ----LSDVKVFEKDEAKFECEVSREPK-TFRWLKGTQEITG--DDRFELIKDGTKHSMVI 11898

Query: 275   KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGD 334
             K     DEA+Y+  AE+K       + ++      +T +++ TA E +E    T E S D
Sbjct: 11899 KSAAFEDEAKYMFEAEDK--HTSGKLIIEGIRLKFLTPLKDVTAKE-KESAVFTVELSHD 11955

Query: 335   PIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 394
              I                +  W + +++      + ++   +  S+T K +   D  +  
Sbjct: 11956 NI----------------RVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIR 11999

Query: 395   CTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW-EGNQVNITCEVFAYPSATISWFRDGQ 453
               A   +G  S++    ++  P   G +  YT  E ++V + CE+ +   A + WF+DG+
Sbjct: 12000 VEA---MGMSSEAKLTVLEGDPYFTGKLQDYTGVEKDEVILQCEI-SKADAPVKWFKDGK 12055

Query: 454   LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC-----TAVNRIGQESLEFILVQAD 508
              +  S  + IK         L+     ++D G Y C         ++  E  E  LV+  
Sbjct: 12056 EIKPSKNAVIKADGKKRMLILKKA--LKSDIGQYTCDCGTDKTSGKLDIEDREIKLVR-- 12111

Query: 509   TPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME 568
                  S++ +E  ++  + +  E +           A W+  GE +  +   + KE    
Sbjct: 12112 --PLHSVEVMETETARFETEISEDD---------IHANWKLKGEALLQTPDCEIKEEGKI 12160

Query: 569   GIVTIVGLKPETTYAVRLAALNGK 592
               + +   + + T  V   A N K
Sbjct: 12161 HSLVLHNCRLDQTGGVDFQAANVK 12184



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 110/480 (22%), Positives = 180/480 (37%), Gaps = 57/480 (11%)

Query: 273   TIKKVDKNDEAEYICIAENKAGEQD---ATIHLKVFAKPKITYVENQTAMELE--EQVTL 327
             T K +++  E ++   AEN AG  +   AT   K         V  +T++E++  +++ L
Sbjct: 14640 TAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGDEIAL 14699

Query: 328   TCEASGDPIPSITWRTSTRNISSEE----KASWTRPEKQETLDGHMVV----------RS 373
                 SG P P+ITW      I  EE     A   R  K E  +    V           S
Sbjct: 14700 DASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNS 14759

Query: 374   HARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP---------KLQGPVAV 424
                 S L ++     D G Y+    N  G       + V   P          ++    +
Sbjct: 14760 KKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPINFVFEDIRKTSVL 14819

Query: 425   YTWE------GNQ-VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVT 477
               WE      G++ +N T E          W      L    YS  K+       YL   
Sbjct: 14820 CKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIE--GKEYL-FR 14876

Query: 478   PDSENDFG-NYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATG 536
               +EN FG    C +   + ++         D P  P ++ V   S++  V+++EP+  G
Sbjct: 14877 VRAENRFGPGPPCVSKPLVAKDPFG----PPDAPDKPIVEDVT--SNSMLVKWNEPKDNG 14930

Query: 537   GVPILKYKAEWRAVGEEVW---HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG 593
               PIL Y  E R V    W   +    +A +A+++G+  + GL    TY  R+ A N  G
Sbjct: 14931 S-PILGYWLEKREVNSTHWSRVNKSLLNALKANVDGL--LEGL----TYVFRVCAENAAG 14983

Query: 594   LGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQ--DDGGSPIRHYLVRYRA 651
              G+ S  S+ KT      P  P +         +I++       + GG  + +++ +   
Sbjct: 14984 PGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLV 15043

Query: 652   LSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPA 711
              ++EW              +K +   A+Y++ V A N  G+         T A+P   PA
Sbjct: 15044 GTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPA 15103



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 98/450 (21%), Positives = 169/450 (37%), Gaps = 59/450 (13%)

Query: 269   SSQLTIKKVDKNDEAEYICIAENKAGEQDA-TIHLKVFAK-----PKITYVENQTAMELE 322
             S Q  I  + + +E  +  +A N+ G  D  ++ + + AK     P +    +  ++++ 
Sbjct: 23185 SLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVG 23244

Query: 323   EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTL 382
             + + +    SG P P+ITW      +        TR    ++LD          +++L++
Sbjct: 23245 QDLKIEVPISGRPKPTITWTKDGLPLKQT-----TRINVTDSLD----------LTTLSI 23289

Query: 383   KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAY 441
             K     D G+Y  T +N +GQ + S+ +     P   +GPV         + ++      
Sbjct: 23290 KETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWN---- 23345

Query: 442   PSATISWFRDGQLLPSSNYSNIKIYNTPSASY----LEVTPDSENDFGNYNCTAVNRIGQ 497
             P       +    +     +   +++  SA+     L+VT         +   A NR GQ
Sbjct: 23346 PPLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQ 23405

Query: 498   E-SLEFILVQADTPSSPSIDQVEPYSSTAQ-----VQFDEPEATGGVPILKYKAE----- 546
               +LE   + A  P         P+++        +Q+ EP   GG P++ Y  E     
Sbjct: 23406 SFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERN 23465

Query: 547   ---WRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEF 603
                W  V + + H   + A+    EGI           Y  R+ A N  G+G+ S  SE 
Sbjct: 23466 SILWTKVNKTIIHDTQFKAQNLE-EGI----------EYEFRVYAENIVGVGKASKNSEC 23514

Query: 604   KTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRAL-SSEWKPEIR 661
                    +P  P     +    N I +   K   DGGS I  Y+V  R L    W     
Sbjct: 23515 YVARDPCDP--PGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASF 23572

Query: 662   LPSGSDHVMLKSLDWNAEYEVYVVAENQQG 691
                      +  L  +  YE  V+A+N  G
Sbjct: 23573 TNVIETQFTVSGLTEDQRYEFRVIAKNAAG 23602



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 81/380 (21%), Positives = 146/380 (38%), Gaps = 32/380 (8%)

Query: 338   SITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA 397
             ++ W+    N  S  +       + +  D   V +     +S  ++++      E+   A
Sbjct: 15312 TLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVKA 15371

Query: 398   SNTIGQDSQSMYL-------EVQYAPKLQGPV---AVYTWEGNQVNITCEVFAYPSATIS 447
              N IG+   S+ L       EV    KL+  V    +    G  V+I  +V   P   I 
Sbjct: 15372 VNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIE 15431

Query: 448   WFRDGQLLPSSN----YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 503
             W ++  ++         +  ++  + + + L +      D G Y  TA NR+G       
Sbjct: 15432 WSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVH 15491

Query: 504   LVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDA 562
             +   D PS P ++   +  + +  + +D P   GG  I  Y  + R    +   ++W + 
Sbjct: 15492 VEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKRDASRK--KAEWEEV 15549

Query: 563   KEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP---VQGEPSAPKLEG 619
                ++E    I  L P   Y  R+ A+N  G+ +   + +   Q    + G P  PK+  
Sbjct: 15550 TNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLA 15609

Query: 620   QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSE-WKPEIRLPSGSDHVMLKSLDWN- 677
             +    G+ +       D+GGSPI  Y +  R   S  W    R P     V LK +++N 
Sbjct: 15610 R--TKGSMLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAP--ITKVGLKGVEFNV 15665

Query: 678   ------AEYEVYVVAENQQG 691
                    +Y+   +A N  G
Sbjct: 15666 PRLLEGVKYQFRAMAINAAG 15685



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 100/465 (21%), Positives = 179/465 (38%), Gaps = 63/465 (13%)

Query: 269   SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA---------KPKITYVENQTAM 319
             ++   ++ +D++   E+   A N+ GE + ++ L V           K +++   +   +
Sbjct: 15351 TTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKV 15410

Query: 320   ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS 379
             +  E V +  + +G P+P I W        S+ +    +P     +    V RS A+   
Sbjct: 15411 KAGEPVHIPADVTGLPMPKIEW--------SKNETVIEKPTDALQITKEEVSRSEAKTEL 15462

Query: 380   LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAV---------YTWEGN 430
                K+++  D G Y  TASN +G   +++++EV   P     +AV          TW+  
Sbjct: 15463 SIPKAVR-EDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAP 15521

Query: 431   QVNITCEVFAY-------PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEND 483
               N   E+  Y             W           Y   K+   P+  Y E    + N 
Sbjct: 15522 LDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKL--IPNGQY-EFRVRAVNK 15578

Query: 484   FG-NYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 542
             +G +  C +   + Q+           P  P +  +     +  V +  P   GG PI  
Sbjct: 15579 YGISDECKSDKVVIQDPYRL----PGPPGKPKV--LARTKGSMLVSWTPPLDNGGSPITG 15632

Query: 543   YKAEWRAVGEEVW-HSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAA 600
             Y  E R  G   W         +  ++G+   +  L     Y  R  A+N  G+G  S  
Sbjct: 15633 YWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEP 15692

Query: 601   S--EFKTQPV--QGEPSAPKLEGQMGEDGNSIKVNL---IKQDDGGSPIRHYLVRYRAL- 652
             S  E    P+   G PS P++     +D     ++L       DGGSPI+ Y+V  +   
Sbjct: 15693 SDPEVAGDPIFPPGPPSCPEV-----KDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEG 15747

Query: 653   SSEWKPEIRLPS---GSDHVMLKSLDWNAEYEVYVVAENQQGKSK 694
             +++WK  +  P     +   ++ +L    +Y   V A N+ G+S+
Sbjct: 15748 TTDWK-RVNEPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESE 15791



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 65/266 (24%), Positives = 105/266 (39%), Gaps = 12/266 (4%)

Query: 429   GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
             G+ + ++  +   P   ++W ++ +  P+      +I  TP  S LE+   +  D G Y+
Sbjct: 17233 GDTLRLSAIIKGVPFPKVTWKKEDRDAPTK----ARIDVTPVGSKLEIRNAAHEDGGIYS 17288

Query: 489   CTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 547
              T  N  G +++   ++  D P  P  ++  E    +  + + EP   GG  I  Y  E 
Sbjct: 17289 LTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVER 17348

Query: 548   RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE-ISAASEFKTQ 606
             R V    W      +K+ S         L     Y  R+AA N  G G  +      K  
Sbjct: 17349 RDVASAQWSPLSATSKKKSH----FAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKAL 17404

Query: 607   PVQGEPSAPKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALSSEWKPEIRLPSG 665
                  P  PK    +  D   + +   K D DGGSPI  YLV Y+   ++   + +  + 
Sbjct: 17405 DPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTN 17464

Query: 666   SDHVMLKSLDWNAEYEVYVVAENQQG 691
              + V +  L     Y   V AEN  G
Sbjct: 17465 LECV-VTGLQQGKTYRFRVKAENIVG 17489



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 75/341 (21%), Positives = 122/341 (35%), Gaps = 68/341 (19%)

Query: 211  PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270
            PPT+ +   + N T   G+SVTL C   G+P PT++W ++  QIE   D +   F    +
Sbjct: 942  PPTLVS--GLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQ-ITFQSGIA 998

Query: 271  QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330
            +L I++    D   + C A N+AG    + +L V           Q + E E++ T    
Sbjct: 999  RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV-----------QVSEEFEKETTAV-- 1045

Query: 331  ASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDA 390
                          T   ++EEK           ++   VV        +T  S+    A
Sbjct: 1046 --------------TEKFTTEEK---------RFVESRDVV--------MTDTSLTEEQA 1074

Query: 391  GEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFR 450
            G          G+ +   ++      KL         EG  V   C+V   P   + W +
Sbjct: 1075 GP---------GEPAAPYFITKPVVQKLV--------EGGSVVFGCQVGGNPKPHVYWKK 1117

Query: 451  DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE-FILVQADT 509
             G  L +     +          L ++    +D G Y     N+ G+ S    +L +AD 
Sbjct: 1118 SGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADY 1177

Query: 510  PSSPSIDQVEPYSSTAQVQFDEP---EATGGVPILKYKAEW 547
                   Q   Y +       EP   E   G    +Y+ E+
Sbjct: 1178 ELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEY 1218



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 71/303 (23%), Positives = 121/303 (39%), Gaps = 54/303 (17%)

Query: 325   VTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKS 384
             + +    SG P P++TW  + R +  E                   + + A  SS+ +K+
Sbjct: 16542 IRIIAYVSGKPPPTVTWNMNERTLPQEA-----------------TIETTAISSSMVIKN 16584

Query: 385   IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSA 444
              Q +  G Y   A N  G+  +++ ++V   P   GPV       N  N +C+       
Sbjct: 16585 CQRSHQGVYSLLAKNEAGERKKTIIVDVLDVP---GPVGTPFLAHNLTNESCK------- 16634

Query: 445   TISWF--RDGQLLPSSNYSNIK----------IYNTPSASYLEVTPDSENDFGNYNCTAV 492
              ++WF   D    P +NY   K          +  T +     V    +     +   A 
Sbjct: 16635 -LTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAE 16693

Query: 493   NRIGQ----ESLEFILVQAD--TPSSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKA 545
             N IG     E+ E ++++     P  P  ++  E   +T  + ++ P+  GG  I+ Y  
Sbjct: 16694 NSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVL 16753

Query: 546   EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKT 605
             E R +G E +H    D     +    T+ GLK   TY  R++A+N  G G+ S    F T
Sbjct: 16754 ESRLIGTEKFHKVTNDNL---LSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPS----FCT 16806

Query: 606   QPV 608
             +P+
Sbjct: 16807 KPI 16809



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 102/402 (25%), Positives = 160/402 (39%), Gaps = 71/402 (17%)

Query: 323   EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTL 382
             E + +  + +G P+P I+W      I  EE+A   R E   T D H +         LT+
Sbjct: 25805 EVLKINADIAGRPLPVISWAKD--GIEIEERA---RTEIIST-DNHTL---------LTV 25849

Query: 383   KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAY 441
             K     D G+Y+ T  N  G  S ++  +V   P    GP+ +         +T E    
Sbjct: 25850 KDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEIN-------GLTAE---- 25898

Query: 442   PSATISWFR---DGQLLPSSNYSNIKIYNTPSASYL-----------EVTPDSENDFGNY 487
                ++SW R   DG      +Y  ++   T   ++            +VT   + +   +
Sbjct: 25899 -KCSLSWGRPQEDGGA--DIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIF 25955

Query: 488   NCTAVNRIGQ-ESLEFILVQA----DTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPIL 541
               T VN+ G  E LE + ++A      PS P S++       +  + +  PE+ GG  I 
Sbjct: 25956 RVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEIS 26015

Query: 542   KYKAEWRAVGEEVW----HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 597
              Y  E R      W        YD +  S        GL+    Y  R+ A N  GL   
Sbjct: 26016 GYIIERREKNSLRWVRVNKKPVYDLRVKS-------TGLREGCEYEYRVYAENAAGLSLP 26068

Query: 598   SAASEF--KTQPV--QGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRY-RA 651
             S  S       PV     PS PK+   +     +I +  +K   DGG+PI  Y V Y ++
Sbjct: 26069 SETSPLIRAEDPVFLPSPPSKPKI---VDSGKTTITIAWVKPLFDGGAPITGYTVEYKKS 26125

Query: 652   LSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 693
               ++WK  I+   G+++  +  L   AEY   V + N+ G S
Sbjct: 26126 DDTDWKTSIQSLRGTEYT-ISGLTTGAEYVFRVKSVNKVGAS 26166



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 82/352 (23%), Positives = 136/352 (38%), Gaps = 67/352 (19%)

Query: 271   QLTIKKVDKNDEAEY-ICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTC 329
             Q T+ K+ +N E  + IC   ++   + AT+   V A+ +I   E +   +L + V L  
Sbjct: 25062 QFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRA 25121

Query: 330   EAS--------GDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS-- 379
              A+        G P P + W                     E  +G +  R+   V+S  
Sbjct: 25122 SATLRLFVTIKGRPEPEVKW---------------------EKAEGILTDRAQIEVTSSF 25160

Query: 380   --LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCE 437
               L + ++   D+G Y  T  N  G  S++ ++ V+       PV          N+T  
Sbjct: 25161 TMLVIDNVTRFDSGRYNLTLENNSG--SKTAFVNVRVLDSPSAPV----------NLTIR 25208

Query: 438   VFAYPSATISW---FRDG-----QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN--- 486
                  S T+SW     DG       +     +  K Y T + +  + T   EN       
Sbjct: 25209 EVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSY 25268

Query: 487   -YNCTAVNRIG----QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPIL 541
              +   A N  G     E+ E + V         +  V+   +TA +++++PE+ GG  I 
Sbjct: 25269 YFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKIT 25328

Query: 542   KYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG 593
              Y  E +  G E W +     +  ++E   TI GL     Y  R+AA+N KG
Sbjct: 25329 GYVVEMQTKGSEKWST---CTQVKTLE--ATISGLTAGEEYVFRVAAVNEKG 25375



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 91/428 (21%), Positives = 147/428 (34%), Gaps = 41/428 (9%)

Query: 314   ENQTAMELEEQVTLTCEASGDPIP--SITWRTSTRNISSEEKASWTRPEKQ--ETLDGHM 369
             EN+  + L  +   + +AS  P+P   IT    TRN  S    SW +PE      + G++
Sbjct: 22028 ENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVS---LSWEKPEHDGGSRILGYI 22084

Query: 370   VVR-----------SHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL 418
             V             +  +V+  T+  +   +   +  +A N  G            A  L
Sbjct: 22085 VEMQTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDL 22144

Query: 419   QGPVAVY-------TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSA 471
               P A            G  + +       P+  ++W +D   +P    + +   +T + 
Sbjct: 22145 VIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDN--VPLKQTTRVNAESTENN 22202

Query: 472   SYLEVTPDSENDFGNYNCTAVNRIGQ--ESLEFILVQADTPSSPSIDQVEPYSSTAQVQF 529
             S L +      D G+Y     N  G+  E+L  I++    P +  +   E  + +  + +
Sbjct: 22203 SLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSW 22262

Query: 530   DEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL 589
               P+  GG  I  Y  E R      W          +++       LK    Y  R+AA 
Sbjct: 22263 GPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKAC----RLKTGCEYQFRIAAE 22318

Query: 590   NGKGLGEISAASEFKTQ---PVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYL 646
             N  G      +     Q    V G P  P +      D   ++ N    D G   I ++L
Sbjct: 22319 NRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVT-LSSRDSMEVQWNEPISDGGSRVIGYHL 22377

Query: 647   VRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAH----FVFRT 702
              R    S  W    + P          L+   EYE  V AEN  G  K +     +V R 
Sbjct: 22378 ERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARD 22437

Query: 703   SAQPTAIP 710
                P   P
Sbjct: 22438 PCDPPGRP 22445



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 92/399 (23%), Positives = 154/399 (38%), Gaps = 62/399 (15%)

Query: 325   VTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKS 384
             V L    +G P P+ +W  +   +   E+ +               V +H +V+ LT++ 
Sbjct: 29756 VELVIPIAGRPPPAASWFFAGSKLRESERVT---------------VETHTKVAKLTIRE 29800

Query: 385   IQYTDAGEYICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPS 443
                 D GEY     N  G  S+++ + +   P    GP+ +     ++++ T       S
Sbjct: 29801 TTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIKI-----DEIDAT-------S 29848

Query: 444   ATISW---FRDGQLLPSSNY----------SNIKIYNTPSASYLEVTPDSENDFGNYNCT 490
              TISW     DG   P S Y            + +  + + S  + T  +E +   +   
Sbjct: 29849 ITISWEPPELDGG-APLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVA 29907

Query: 491   AVNRIGQES-LEFILVQADT----PSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPILKYK 544
             A NR G  S L+  +++  +    P  P   Q+   S     + +  PE  GG  +  Y 
Sbjct: 29908 ATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYI 29967

Query: 545   AEWRAVGEEVWHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASEF 603
              E     +EV   +W    +  +        GL     Y  R+ A+N +G G+ S  S+ 
Sbjct: 29968 VE----RKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSK- 30022

Query: 604   KTQPVQGEPSAP--KLEGQMGEDGNSIKVNL---IKQDDGGSPIRHYLVRYRALSS-EWK 657
                 V  +P AP  K +     D     V+L   + +D+GGS +  YL+  + +   EW 
Sbjct: 30023 --PIVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWT 30080

Query: 658   PEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 696
                  P+      L  L   AEY   V+A N  G  + A
Sbjct: 30081 KCNTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPA 30119



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 82/400 (20%), Positives = 134/400 (33%), Gaps = 96/400 (24%)

Query: 105   ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDV 164
             E   T  +K          P      EGE A   CD      PT+ W  KG+  +L    
Sbjct: 32548 EKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQ--VLSTSA 32605

Query: 165   RFIVLSNNY---LQIRGIKKTDEGTY-----RCEGRILARGEINFKDIQV---IVNVPPT 213
             R  V +  Y    +I  ++ +DEG Y       EG+  A   +  +  +V    V  PP 
Sbjct: 32606 RHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPR 32665

Query: 214   IQARQNIVNATANLGQSVTL----------VCDAEGFPEPT------------------- 244
             +++ +  V +   +     +          V   E  P PT                   
Sbjct: 32666 VKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLK 32725

Query: 245   -----------------------MSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKND 281
                                    ++W KDG+++++    + +  +D + +L I  + ++D
Sbjct: 32726 AEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESD 32785

Query: 282   EAEYICIAENKAGEQDA----------TIHLKVFAKPKITYVENQTAMELEEQVTLTCEA 331
             + EY+C    + G              +IH KV    KI+  +       E  VT   E 
Sbjct: 32786 QGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKV---SKISETKKSDQKTTESTVTRKTEP 32842

Query: 332   SG-DPI---PSITWRTSTRNISSEEKAS--------------WTRPEKQETLDGHMVVRS 373
                +PI   P I        +SS+  A               WT+  K  T  G   +  
Sbjct: 32843 KAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSE 32902

Query: 374   HARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 413
                   L +     +D+G Y CT  N+ G  S S  L ++
Sbjct: 32903 DKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIK 32942



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 97/425 (22%), Positives = 163/425 (38%), Gaps = 76/425 (17%)

Query: 24   IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTI 83
            + P    +  GE+  F C+V G  + K ++W+  NG+ L    +R  V +  D    L I
Sbjct: 1845 LYPEPVRVLEGETARFRCRVTGYPQPK-VNWYL-NGQ-LIRKSKRFRVRY--DGIHYLDI 1899

Query: 84   YNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKN----APTPQ-EFREGEDAVIV 138
             +    D G  K      +G   E  V ++I Q+  F++    AP P+ EF   E   + 
Sbjct: 1900 VDCKSYDTGEVKVTAENPEGV-IEHKVKLEIQQREDFRSVLRRAPEPRPEFHVHEPGKLQ 1958

Query: 139  CDVVSSLPPTIIWKHKGRDVILKKDVRF----IVLSNNYLQIRGIKKTDEGTYRC----- 189
             +V     P    + K   V LK+  R     +   +  L+ +  ++T+EG Y       
Sbjct: 1959 FEVQKVDRPVDTTETK-EVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAITAVE 2017

Query: 190  -------------------------------EGRILAR-GEINFKDIQVI-VNVPPTIQA 216
                                           E + LA  G+I     +   + + P+++A
Sbjct: 2018 LKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEA 2077

Query: 217  R---QNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLT 273
                + I + T   G          G P+P   W K+G +IE+ +    Y   D+  +L 
Sbjct: 2078 PKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELV 2137

Query: 274  IKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITY---VENQTAMELEEQVTLTCE 330
            I+ V   D A  +  A N AGE  +   L V AK  IT+   +++  A E +   T  CE
Sbjct: 2138 IRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECE 2197

Query: 331  ASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDA 390
             S +P   + W      +   +K                 + S  +V  L++ +I  +DA
Sbjct: 2198 TS-EPFVKVKWYKDGMEVHEGDKYR---------------MHSDRKVHFLSILTIDTSDA 2241

Query: 391  GEYIC 395
             +Y C
Sbjct: 2242 EDYSC 2246



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 78/300 (26%), Positives = 120/300 (40%), Gaps = 25/300 (8%)

Query: 429   GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
             G  + +   V   P   I+W + G  L S       I  T S S L V   +  D G Y 
Sbjct: 29461 GASLRLMVSVSGRPPPVITWSKQGIDLASRAI----IDTTESYSLLIVDKVNRYDAGKYT 29516

Query: 489   CTAVNRIGQESLEFILVQADTPS-SPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 547
               A N+ G++S   ++   DTP   PS+   E    +  + ++ P   GG P+  Y  E 
Sbjct: 29517 IEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEK 29576

Query: 548   RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 607
             R      + +          + +  I GL   T Y  R+   N  G+GE    S+     
Sbjct: 29577 REAAMRAFKT----VTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSD--AVL 29630

Query: 608   VQGEPSAP-KLEGQMGEDGNSIKVNLIKQD---DGGSPIRHYLVR-YRALSSEWKPEIRL 662
             V   P  P KLE     D     V L  +    DGGS +  Y++   +A +  W   + L
Sbjct: 29631 VSEVPLVPAKLE---VVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTL 29687

Query: 663   -PSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLST 721
              P+  +H  + SL+   +Y   + A+N++G S+    V   + Q   +     PT  LST
Sbjct: 29688 KPTVLEHT-VTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRV----LPTIDLST 29742



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 125/601 (20%), Positives = 234/601 (38%), Gaps = 105/601 (17%)

Query: 39    FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVV 98
             F CQ++ +  +  + W+  NG ++   ++       D S   L I +  +DD   Y C  
Sbjct: 12842 FSCQLSREKAN--VKWYR-NGREIKEGKKY--KFEKDGSIHRLIIKDCRLDDECEYAC-- 12894

Query: 99    TGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDV 158
              G +  +S A + V   +++  +    PQ+  E   A +V     +     +   +   V
Sbjct: 12895 -GVEDRKSRARLFV---EEIPVEIIRPPQDILEAPGADVVFLAELNKDKVEVQWLRNNMV 12950

Query: 159   ILKKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGRIL-ARGEINFKDIQVIVNVPPTIQ 215
             +++ D   ++       LQI  IK  D+G YR   +   AR ++       +   P    
Sbjct: 12951 VVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLE------LAAAPKIKT 13004

Query: 216   ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIK 275
             A Q++V    ++G+ +T+V   + +P+    W K+ E +  +  D     + + +   I 
Sbjct: 13005 ADQDLV---VDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDT----TAEQTSFRIL 13057

Query: 276   KVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDP 335
             +  K D+  Y  + +NK G+ +  I+LKV   P                          P
Sbjct: 13058 EAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVP-------------------------GP 13092

Query: 336   IPSITWRTSTRNISSEEKASWTRP--EKQETLDGHMVVRSHARVSSLTL-----KSIQYT 388
             + ++     T     E   +W  P  +    + G++V R   +  +  L     +S ++T
Sbjct: 13093 VRNLE---VTETFDGEVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFT 13149

Query: 389   DAG------EYI--CTASNTIGQ----------DSQSMY------LEVQYAPKLQGPVAV 424
               G      EY+   +A N +G           +++S Y      L V      +  V++
Sbjct: 13150 VTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSL 13209

Query: 425   YTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 484
              TWE  + +   E+  Y    +   RD   +       ++  +  SA+  +V    E  F
Sbjct: 13210 -TWEPPEYDGGAEITNY----VIELRDKTSIRWDTAMTVRAEDL-SATVTDVVEGQEYSF 13263

Query: 485   GNYNCTAVNRIG----QESLEFILVQ--ADTPSSP-SIDQVEPYSSTAQVQFDEPEATGG 537
                   A NRIG      +  F+ V    + PS P ++   +   S+ Q++++ P   GG
Sbjct: 13264 ---RVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGG 13320

Query: 538   VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 597
              PIL Y  E    G++ W        +   E    + GL+    Y  R++A N  G+ + 
Sbjct: 13321 SPILGYIIERCEEGKDNWIR---CNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDP 13377

Query: 598   S 598
             S
Sbjct: 13378 S 13378



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 107/506 (21%), Positives = 178/506 (35%), Gaps = 68/506 (13%)

Query: 220   IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD- 278
             +   T   G  + L     G PEP ++WTK    ++Q   D++    +   + T+  VD 
Sbjct: 13697 LAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQ---DKRITIENVPKKSTVTIVDS 13753

Query: 279   -KNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIP 337
              ++D   YI  A N  G   A + + V  KP         A ++ +    +C  + +P P
Sbjct: 13754 KRSDTGTYIIEAVNVCGRATAVVEVNVLDKP-----GPPAAFDITDVTNESCLLTWNP-P 13807

Query: 338   SITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYI--C 395
                  +   N   E +A+          D  +  +  + V     K+ +     EYI   
Sbjct: 13808 RDDGGSKITNYVVERRAT----------DSEVWHKLSSTVKDTNFKATKLIPNKEYIFRV 13857

Query: 396   TASNT--IGQDSQSMYLEVQYAPKLQGP------------VAVYTW-----EGNQVNITC 436
              A N   +G+  Q+  +  +Y     GP                TW     +G       
Sbjct: 13858 AAENMYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGY 13917

Query: 437   EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 496
              V      T  W R  ++        +K           V  ++    G           
Sbjct: 13918 WVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGK---------P 13968

Query: 497   QESLEFILVQ--ADTPSSPSIDQVEPYSSTA-QVQFDEPEATGGVPILKYKAEWRAVGEE 553
              +S E IL++   D P  P    V+    T+ ++ + +PE  GG  I  Y  E    G +
Sbjct: 13969 SKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTD 14028

Query: 554   VWHSKWYDAKEASMEGIVT----IVGLKPETTYAVRLAALNGKGLGEISAASE-FKTQPV 608
              W            EG+ T    + GL     Y+ R+ A+N  G  E S  S+    +  
Sbjct: 14029 EW--------VRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREK 14080

Query: 609   QGEPSAPKLEGQMGEDGNSIKVN-LIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSD 667
                PS P+    +    N+  +   + + DGGSPI +Y+V  R +  +    +       
Sbjct: 14081 LYPPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDT 14140

Query: 668   HVMLKSLDWNAEYEVYVVAENQQGKS 693
                +  L   + Y   V AEN  G+S
Sbjct: 14141 KCTVTPLTEGSLYVFRVAAENAIGQS 14166



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 50/190 (26%), Positives = 81/190 (42%), Gaps = 19/190 (10%)

Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE-DDEKYIFSDDSSQLTIKKVDKNDEAEYI 286
           G + T      GFP P +SW +DG+ I        +  FSD  ++LTI  V K +   Y 
Sbjct: 20  GSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYS 79

Query: 287 CIAENKAGEQDATIHLKVFAK-PKITYVENQTAMELEE--QVTLTCEASGDPIPSITWRT 343
             A N +G+  +T  L V A+     +V+   +M + +  QV L    +G P P + +  
Sbjct: 80  LKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYR 139

Query: 344 STRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQ 403
               I             Q +LD    +     + SL +      D+G Y   A+N++G+
Sbjct: 140 DGAEI-------------QSSLD--FQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGR 184

Query: 404 DSQSMYLEVQ 413
            + +  L VQ
Sbjct: 185 ATSTAELLVQ 194



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 110/517 (21%), Positives = 198/517 (38%), Gaps = 97/517 (18%)

Query: 168   VLSNNYLQIRGIKKTDEGTYRCEG-RILARGEINFKDIQVIVN---VPPTIQA--RQNIV 221
             +LS  Y  ++G+K+ D   YR     I+ +G+ +F    +       PPT+    R  + 
Sbjct: 16771 LLSRKYT-VKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKL- 16828

Query: 222   NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIK-KVDKN 280
               T  +G++  L     G P+P +SW KD  + +  EDD  +I +  ++    K K  ++
Sbjct: 16829 --TIRVGEAFALTGRYSGKPKPKVSWFKD--EADVLEDDRTHIKTTPATLALEKIKAKRS 16884

Query: 281   DEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSIT 340
             D  +Y  + EN  G +     + V  +P                        G P+  ++
Sbjct: 16885 DSGKYCVVVENSTGSRKGFCQVNVVDRP------------------------GPPVGPVS 16920

Query: 341   WRTSTRNISSEEKASWTRP-------------EKQET-LDGHMVVRSHARVSSLTLKSIQ 386
             +   T++       SW  P             EK+E   D  M V S +  +  T K  +
Sbjct: 16921 FDEVTKDYMV---ISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSAS--AKTTCKVSK 16975

Query: 387   YTDAGEYICT--ASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSA 444
               +  +YI    A N  G     +   ++   + + P      +     I  EV    SA
Sbjct: 16976 LLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVP------DAPDQPIVTEV-TKDSA 17028

Query: 445   TISWFR--DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN-------CTAVNRI 495
              ++W +  DG   P +NY  ++   T S  +  VT D  + +  +        C    R+
Sbjct: 17029 LVTWNKPHDGGK-PITNYI-LEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRV 17086

Query: 496   GQESLEFILVQADTPSSPSI--------------DQVEPYSSTAQVQFDEPEATGGVPIL 541
               E+ E  +     PS P                + ++   ++  + +  P   GG  IL
Sbjct: 17087 SAEN-EIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKIL 17145

Query: 542   KYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAAS 601
              Y  E++ VG+E W  +     E+  E    + GL+   TY  R+ A+N  G  + +   
Sbjct: 17146 GYIVEYQKVGDEEWR-RANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVP 17204

Query: 602   EFKTQPVQGEPSAPKLEGQMGED-----GNSIKVNLI 633
             E      + EP    L+  M  +     G++++++ I
Sbjct: 17205 EPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAI 17241



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 60/254 (23%), Positives = 106/254 (41%), Gaps = 14/254 (5%)

Query: 442   PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 501
             P   I+W +    L      +IK  +T   ++L     ++ D G Y  T  N  G++   
Sbjct: 19721 PPPKITWSKPNVNLRDRIGLDIK--STDFDTFLRCENVNKYDAGKYILTLENSCGKKEYT 19778

Query: 502   FILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWY 560
              ++   DTP  P ++   E    +A V ++ P   GG PI+ Y  + R    + W +   
Sbjct: 19779 IVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTT 19838

Query: 561   DAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQ 620
             +  + S      +  L+   +Y  R+ A N  G+G+     E +      +   P ++ +
Sbjct: 19839 ECSKTSFR----VANLEEGKSYFFRVFAENEYGIGD---PGETRDAVKASQTPGPVVDLK 19891

Query: 621   M-GEDGNSIKVNLIK-QDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNA 678
             +     +S  +   K   DGGS I  Y+V +    ++W+  ++  S S     K L    
Sbjct: 19892 VRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENKWQRVMK--SLSLQYSAKDLTEGK 19949

Query: 679   EYEVYVVAENQQGK 692
             EY   V AEN+ G+
Sbjct: 19950 EYTFRVSAENENGE 19963



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 68/270 (25%), Positives = 99/270 (36%), Gaps = 12/270 (4%)

Query: 429   GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
             G  + I  ++   P   ISW +DG  +     +  +I +T + + L V      D G Y 
Sbjct: 25804 GEVLKINADIAGRPLPVISWAKDG--IEIEERARTEIISTDNHTLLTVKDCIRRDTGQYV 25861

Query: 489   CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKA 545
              T  N  G  S+       D P  P+   +E    TA+   + +  P+  GG  I  Y  
Sbjct: 25862 LTLKNVAGTRSVAVNCKVLDKPGPPA-GPLEINGLTAEKCSLSWGRPQEDGGADIDYYIV 25920

Query: 546   EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKT 605
             E R    E  H  W   +         +  L     Y  R+  +N  G+GE   +   K 
Sbjct: 25921 EKR----ETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKA 25976

Query: 606   QPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLVRYRALSS-EWKPEIRLP 663
                   PS P           S+ +   + + DGGS I  Y++  R  +S  W    + P
Sbjct: 25977 LDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKP 26036

Query: 664   SGSDHVMLKSLDWNAEYEVYVVAENQQGKS 693
                  V    L    EYE  V AEN  G S
Sbjct: 26037 VYDLRVKSTGLREGCEYEYRVYAENAAGLS 26066



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 50/183 (27%), Positives = 85/183 (46%), Gaps = 18/183 (9%)

Query: 190   EGRILARGEINFKDIQVIVNV-------PPTIQARQNIVNATANL--GQSVTLVCDAEGF 240
             E R+ A  EI   +  + +NV       PPTI+ R ++   T  +  G+ V +  D  G 
Sbjct: 15366 EFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGL 15425

Query: 241   PEPTMSWTKDGEQIEQEED-----DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295
             P P + W+K+   IE+  D      E+   S+  ++L+I K  + D+  Y   A N+ G 
Sbjct: 15426 PMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGS 15485

Query: 296   QDATIHLKVFAKPKITYVENQTAMELE-EQVTLTCEASGDPIPS-ITWRTSTRNISSEEK 353
                 +H++V+ +P  +   N    +++ E   LT +A  D   S IT     +  +S +K
Sbjct: 15486 VFRNVHVEVYDRP--SPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKRDASRKK 15543

Query: 354   ASW 356
             A W
Sbjct: 15544 AEW 15546



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 68/300 (22%), Positives = 117/300 (39%), Gaps = 25/300 (8%)

Query: 429   GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSE------- 481
             G+Q+ I   +   P+   SW  DG+   +       +++ P  + LE   +S        
Sbjct: 15825 GSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDG---VHDIPEDAQLETAENSSVIIIPEC 15881

Query: 482   --NDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGV 538
               +  G Y+ TA N+ GQ++    +   D P  P   +V   +  + ++ +  P+  GG 
Sbjct: 15882 KRSHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWKMPDDDGGD 15941

Query: 539   PILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 598
              I  Y  E R +  + W     D    +      +  L  E  Y  R+ A N  G+G   
Sbjct: 15942 RIKGYVIEKRTIDGKAWTKVNPDCGSTTF----VVPDLLSEQQYFFRVRAENRFGIGPPV 15997

Query: 599   AASEFKTQPVQGEPSAPKLEGQMGE-DGNSIKVNLIK-QDDGGSPIRHYLVRYRA----- 651
                +  T      P  P ++ ++G    N++ ++    ++DGGSP+ HY+V   A     
Sbjct: 15998 ETIQRTTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTG 16057

Query: 652   -LSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIP 710
                  W+   +         ++ L    EYE  V A N  G SK +  V     Q   +P
Sbjct: 16058 TKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMP 16117



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 66/303 (21%), Positives = 115/303 (37%), Gaps = 13/303 (4%)

Query: 430   NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 489
             N + I      YP  T +W    ++L + +   +K+    + + L ++P   +D G Y  
Sbjct: 13410 NPITILVPSTGYPRPTATWCFGDKVLETGD--RVKMKTLSAYAELVISPSERSDKGIYTL 13467

Query: 490   TAVNRIGQESLEFILVQADTPSSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWR 548
                NR+   S E  +     PS+P  +   +    +  + ++ P+  GG P+  Y  E R
Sbjct: 13468 KLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKR 13527

Query: 549   AVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPV 608
              V  + W        +       T+  L     Y  ++ A N  G GE +   E      
Sbjct: 13528 EVSRKTWTKVMDFVTDLEF----TVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMST 13583

Query: 609   QGE-PSAPKLEGQMGEDGNSIKVNL-IKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGS 666
                 P  P+         NSI +     ++DGGS I+ Y+V      S+       P   
Sbjct: 13584 PATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPVAE 13643

Query: 667   DHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVG 726
               + +  L+    Y   V A N+QG SK +    R + +  A+    +P   L    + G
Sbjct: 13644 TKMEVTGLEEGKWYAYRVKALNRQGASKPS----RPTEEIQAVDTQEAPEIFLDVKLLAG 13699

Query: 727   ILI 729
             + +
Sbjct: 13700 LTV 13702



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 103/471 (21%), Positives = 179/471 (38%), Gaps = 68/471 (14%)

Query: 257   EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE---QDATI---------HLKV 304
             EE+  + +    S Q + K + +  E  +   AEN+ GE    + T+          L +
Sbjct: 19925 EENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDL 19984

Query: 305   FAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQET 364
                P + Y+  + +        L     G P PS++W+     ++++ + S         
Sbjct: 19985 KGLPDLCYLAKENS-----NFRLKIPIKGKPAPSVSWKKGEDPLATDTRVS--------- 20030

Query: 365   LDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVA 423
                   V S A  ++L +   Q +DAG+Y  T  N  G    ++ ++V   P +  GP+ 
Sbjct: 20031 ------VESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIK 20084

Query: 424   VYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSA---SYLEVTPDS 480
                     + +    +A P           +L   +  N K     SA   +   VT   
Sbjct: 20085 FDEVTAEAMTLK---WAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLH 20141

Query: 481   ENDFGNYNCTAVNRIGQ-ESLEFILVQA-------DTPSSPSIDQVEPYSSTAQVQFDEP 532
             E     +  +A N+ G  E L+   + A       D P  P+I  V+    +  + + +P
Sbjct: 20142 EGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNI--VDVRHDSVSLTWTDP 20199

Query: 533   EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGI----VTIVGLKPETTYAVRLAA 588
             + TGG PI  Y  E++     +W       K A+   I      + GL     Y  R+ A
Sbjct: 20200 KKTGGSPITGYHLEFKERNSLLW-------KRANKTPIRMRDFKVTGLTEGLEYEFRVMA 20252

Query: 589   LNGKGLGEISAASE--FKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHY 645
             +N  G+G+ S  SE      P+   P  P++   +    NS+ +   + + DGG  +  Y
Sbjct: 20253 INLAGVGKPSLPSEPVVALDPID-PPGKPEV---INITRNSVTLIWTEPKYDGGHKLTGY 20308

Query: 646   LVRYRAL-SSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 695
             +V  R L S  W     +        +  L    +YE  + A+N  G   A
Sbjct: 20309 IVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISA 20359



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 101/434 (23%), Positives = 164/434 (37%), Gaps = 49/434 (11%)

Query: 284   EYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIP-SITWR 342
             E+  IAEN AG+   +       KP     E   A++         +  G P+P +IT  
Sbjct: 21330 EFRVIAENMAGKSKPS-------KPS----EPMLALD-------PIDPPGKPVPLNITRH 21371

Query: 343   TSTRNISSEE-----KASWTRPEKQETLDGHMVVRSHARV--SSLTLKSIQYTDAGEYIC 395
             T T   +  E     K +    EK++  +G  +  + + +  +  T+  +    A E+  
Sbjct: 21372 TVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRV 21431

Query: 396   TASNTIG--------QDSQSMYLEVQYAPKLQGPV----AVYTWEGNQVNITCEVFAYPS 443
              A N  G         D+ +   +V+ APK++  V     V    G    +  +V   P 
Sbjct: 21432 IAKNAAGAISPPSEPSDAITCRDDVE-APKIKVDVKFKDTVILKAGEAFRLEADVSGRPP 21490

Query: 444   ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 503
              T+ W +DG+ L  +    IKI     ++ L     +  D G Y  TA N  G     F 
Sbjct: 21491 PTMEWSKDGKELEGTAKLEIKI--ADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFN 21548

Query: 504   LVQADTPSSPS--IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYD 561
             +   D P  P   +   E  S    + +  P   GG  I  Y  + R      W +   +
Sbjct: 21549 VKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASE 21608

Query: 562   AKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQM 621
              +   ++    +  L     Y  R+ A+N  G+GE   +         G P  PK     
Sbjct: 21609 VQVTKLK----VTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVT 21664

Query: 622   GEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALSSEWKPEIRLPSGSD-HVMLKSLDWNAE 679
                 +S+ V     D DGGS I +Y+V  R  + +   +    + +D    +  L    E
Sbjct: 21665 TITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHE 21724

Query: 680   YEVYVVAENQQGKS 693
             YE  ++AEN  G S
Sbjct: 21725 YEFRIMAENAAGIS 21738



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 86/409 (21%), Positives = 160/409 (39%), Gaps = 44/409 (10%)

Query: 209   NVPPTIQARQNIVNATA-NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267
             NVPP ++      +      G+S+ +    +G P P ++W KDG +IE+  + E    +D
Sbjct: 27953 NVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNME---ITD 28009

Query: 268   --DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQV 325
                S+ L ++   ++    Y   A+N +G   A I +KV   P       +      E++
Sbjct: 28010 VLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKM 28069

Query: 326   TLTCEAS-GDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKS 384
             TL  +A   D    IT     +  +S  + +W             ++       S T   
Sbjct: 28070 TLWWDAPLNDGCAPITHYIIEKRETS--RLAWA------------LIEDKCEAQSYTAIK 28115

Query: 385   IQYTDAGEYICTASNTIG----QDSQSMYLEVQY-APKLQGPVAVYTWEGNQVNITCEVF 439
             +   +  ++  +A N  G     DS  +  ++QY  P   G        GN + +T   +
Sbjct: 28116 LINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLT---W 28172

Query: 440   AYP-----SATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNR 494
             A P     S    +  + +   S+ +  +      S +  +VT  +E +   ++  A N 
Sbjct: 28173 ARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAENA 28232

Query: 495   IGQESLEFI--LVQADTPSSPS-----IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 547
              G      I  L++   P +P      +   +   +T  +++ +P   GG+ I+ Y  E 
Sbjct: 28233 AGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEM 28292

Query: 548   RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 596
                    WH       EA ++   T+  L+    Y  R++A+NG G G+
Sbjct: 28293 CKADLGDWHKV---NAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGD 28338



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 72/324 (22%), Positives = 121/324 (37%), Gaps = 44/324 (13%)

Query: 22    VDIVPSQGEI--SVGESKF---FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDD 76
             ++I P  G+I  +VGE      ++C++    +   ++W+   G +   N ++  + + +D
Sbjct: 31565 IEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYF--GVRQLENSEKYEITY-ED 31621

Query: 77    SSSTLTIYNANIDDAGIYKCVVT---GEDGSESEATVN---------VKIFQKLMFKNAP 124
               + L + +    D G Y+C V    GED S +E  V           +   K + +   
Sbjct: 31622 GVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTD 31681

Query: 125   T------PQEFR---------EGEDAVIVCDVVSSLPPTIIWKHKGRDVIL-KKDVRFIV 168
             T      P EF           GE+      +     P + W   G+ +     D ++  
Sbjct: 31682 TMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTF 31741

Query: 169   LSNN---YLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQA-----RQNI 220
              S+     L I  +   D+  Y    R     +     + V ++ PPT        ++ +
Sbjct: 31742 ESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLL 31801

Query: 221   VNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKN 280
              NA    GQSV       G P PT+ W KDG+ +    + E      D   L I+     
Sbjct: 31802 ANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPE 31861

Query: 281   DEAEYICIAENKAGEQDATIHLKV 304
             D   Y   A N AG      HL+V
Sbjct: 31862 DTGYYRVTATNTAGSTSCQAHLQV 31885



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 72/344 (20%), Positives = 123/344 (35%), Gaps = 75/344 (21%)

Query: 228  GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
            GQ+        G P P   W  DG+QI  +   +  I  D +  L I     +D  E+  
Sbjct: 1471 GQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTV 1530

Query: 288  IAENKAGEQDATIHLKVFA---KPKITYVENQTAMELEE--QVTLTCEASGDPIPSITWR 342
            +A+N+AG    ++ L V A   + K  +VE    + ++E  ++ +   A+G+P P I W 
Sbjct: 1531 VAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWL 1590

Query: 343  TSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 402
             ++  I          P K   +     +      ++L + S    D+  Y  TA N  G
Sbjct: 1591 KNSDIIV---------PHKYPKIR----IEGTKGEAALKIDSTVSQDSAWYTATAINKAG 1637

Query: 403  QDSQ--SMYLEVQYAP-----KLQGPVAVY--------------------TWEGNQV--- 432
            +D+    + +EV++A      KL  P   Y                     WE   +   
Sbjct: 1638 RDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDK 1697

Query: 433  -----------------------NITCEV--FAYPSATISWFRDGQLLPSSNYSNIKIYN 467
                                   +  C +     P+  + W  DG+ L ++N   +++ N
Sbjct: 1698 EKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAAN--RLRMIN 1755

Query: 468  TPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 511
                  L+       D G   C A N+ G +     L+  D  S
Sbjct: 1756 EFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKS 1799



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 36/101 (35%), Positives = 49/101 (48%), Gaps = 2/101 (1%)

Query: 209   NVPPTIQARQNIVNA-TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267
             NVPP I     + +  T   G +V L     G P PT+SW KDG  ++  E   K     
Sbjct: 19290 NVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGI-KMAMQR 19348

Query: 268   DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
             +   L +  V++ D  +Y   AEN +G + ATI LKV  KP
Sbjct: 19349 NLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKP 19389



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 96/435 (22%), Positives = 156/435 (35%), Gaps = 58/435 (13%)

Query: 325   VTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKS 384
             V L     G P+P+++W+     +   E           TL+               L S
Sbjct: 19313 VCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLE---------------LFS 19357

Query: 385   IQYTDAGEYICTASNTIGQDSQSMYLEVQYAP---------KLQGPVAVYTWEGNQVNIT 435
             +   D+G+Y  TA N+ G  S ++ L+V   P         K+    A+ +WE    +  
Sbjct: 19358 VNRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGG 19417

Query: 436   CEVFAY-----PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 490
              E+  Y      ++  +W +    +P ++ S  K+               E     +   
Sbjct: 19418 SEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLI--------------EGHEYQFRIC 19463

Query: 491   AVNRIGQESLEFILVQ-ADTPSSPSIDQVEPYSSTAQ-----VQFDEPEATGGVPILKYK 544
             A N+ G     F     A  P  P      P  S        V +  P   GG PI  Y 
Sbjct: 19464 AENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYL 19523

Query: 545   AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 604
              E R      W       ++  +E  +   GL+  T Y  R+ A+N  G G+ S AS+  
Sbjct: 19524 LEKRETQAVNWTKV---NRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAA 19580

Query: 605   -TQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALSSEWKPEIRL 662
               +  Q  P  P          +S+ ++  K   DGGSPI  YLV  +   S+      L
Sbjct: 19581 YARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNL 19640

Query: 663   PSGSDHVMLK--SLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS 720
             P        +   L  + +Y+  V A N+ G S  +    +   +   IP  G   + L 
Sbjct: 19641 PQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLR 19700

Query: 721   TGAIV--GILIVIFV 733
                I+  G+ + ++V
Sbjct: 19701 KTLILRAGVTMRLYV 19715



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 66/275 (24%), Positives = 106/275 (38%), Gaps = 24/275 (8%)

Query: 429   GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
             G  V +   +   P+ TI W++D + L ++  + + + NT   + + +      + G Y 
Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKELQTN--ALVCVENTTDLASILIKDADRLNSGCYE 26944

Query: 489   CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKA 545
                 N +G  S    +   D P  P    +E  + TA+   + +  P   GG  I  Y  
Sbjct: 26945 LKLRNAMGSASATIRVQILDKPGPPG-GPIEFKTVTAEKITLLWRPPADDGGAKITHYIV 27003

Query: 546   EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE------ISA 599
             E R     VW        E   E I+T   +     Y  R+ A+N  G+GE      + A
Sbjct: 27004 EKRETSRVVWSM----VSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVA 27059

Query: 600   ASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRALSS-EWK 657
              + F T    G P   K+        NS+ V   +   DGGS I  Y +  R   S  W 
Sbjct: 27060 KNAFVTPGPPGIPEVTKI------TKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWF 27113

Query: 658   PEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGK 692
               ++         +  L  N++Y+  V A N  G+
Sbjct: 27114 KVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQ 27148



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 93/373 (24%), Positives = 138/373 (36%), Gaps = 79/373 (21%)

Query: 308   PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDG 367
             PKI   E Q  ++  +++ +     G P P+  W+               + E +     
Sbjct: 18900 PKILMPE-QITIKAGKKLRIEAHVYGKPHPTCKWK---------------KGEDEVVTSS 18943

Query: 368   HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP----------K 417
             H+ V      S L +K +   D+G Y  TA N+ G D+Q + + V  AP           
Sbjct: 18944 HLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISD 19003

Query: 418   LQGPVAVYTW----EGNQVNIT------CE------VFAYPSATISWFRDGQLLPSSNYS 461
             +       +W    E    NIT      C+      V A  S T +  R G+L+P   Y 
Sbjct: 19004 IDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEY- 19062

Query: 462   NIKIYNTPSASYLEVTPDSENDFG-NYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEP 520
                I+             +EN FG +   T+   + Q            PS P   +V  
Sbjct: 19063 ---IFRV----------RAENRFGISEPLTSPKMVAQ-------FPFGVPSEPKNARVTK 19102

Query: 521   YSSTA-QVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPE 579
              +     V +D P++ GG PI+ Y  E +     +W  K  D    S E      GL   
Sbjct: 19103 VNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLW-VKANDTLVRSTE--YPCAGLVEG 19159

Query: 580   TTYAVRLAALNGKGLGEISAASEFKT--QPVQGEPSAPKLEGQMGEDGNSIKVNLI---K 634
               Y+ R+ ALN  G    S  +E+ T   PV   P  P++      D     V+LI    
Sbjct: 19160 LEYSFRIYALNKAGSSPPSKPTEYVTARMPVD-PPGKPEV-----IDVTKSTVSLIWARP 19213

Query: 635   QDDGGSPIRHYLV 647
             + DGGS I  Y V
Sbjct: 19214 KHDGGSKIIGYFV 19226



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 99/408 (24%), Positives = 157/408 (38%), Gaps = 62/408 (15%)

Query: 213   TIQARQNIV-NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQ 271
             TI+A   IV NA + LG+           P P  SW+K G+ I +  D  +   +  SS 
Sbjct: 20389 TIKAGDTIVLNAISILGK-----------PLPKSSWSKAGKDI-RPSDITQITSTPTSSM 20436

Query: 272   LTIKKVDKNDEAEYICIAENKAG---EQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
             LTIK   + D  EY   A N  G   E      L V   P    + N +A +     T  
Sbjct: 20437 LTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPP 20496

Query: 329   CEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYT 388
              E  G PI S  +    R  S   +  WT   +         ++S   V++  ++  +Y 
Sbjct: 20497 LEDGGSPIKS--YILEKRETS---RLLWTVVSED--------IQSCRHVATKLIQGNEYI 20543

Query: 389   DAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW 448
                 +  +A N  G+        V+   +   P      E + V          +AT+SW
Sbjct: 20544 ----FRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKN-------TATVSW 20592

Query: 449   FR---DG---------QLLPSSNYSNIKIYNTP-SASYLEVTPDSENDFGNYNCTAVNRI 495
              R   DG         +     +   ++   TP S    +VT   E     +  +A NR 
Sbjct: 20593 KRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRA 20652

Query: 496   G----QESLEFILVQ--ADTPSSPSIDQV-EPYSSTAQVQFDEPEATGGVPILKYKAEWR 548
             G     E+ + +L++  A  P  PS   V +    +A + + +P   GG+ I  Y  E +
Sbjct: 20653 GIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQ 20712

Query: 549   AVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 596
              VG+E W            + +V    L+ +  Y  R++A+N  G+GE
Sbjct: 20713 KVGDEAWIKDTTGTALRITQFVVP--DLQTKEKYNFRISAINDAGVGE 20758



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 94/436 (21%), Positives = 156/436 (35%), Gaps = 71/436 (16%)

Query: 191   GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
             G I AR EI+  +  +       I     +V+A    G++  L  D  G P P + W+KD
Sbjct: 24694 GAITARDEIDAPNASLDPKYKDVI-----VVHA----GETFVLEADIRGKPIPDVVWSKD 24744

Query: 251   GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310
             G+++E+     +   +   + L +K   + D  +YI    N  G +   I +KV  +P  
Sbjct: 24745 GKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGP 24804

Query: 311   TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEE--KASWTRPEKQETLDGH 368
                  +      E+  L   A   P+       S   I   E  + SWT+   +      
Sbjct: 24805 PEGPLKVTGVTAEKCYL---AWNPPLQDGGANISHYIIEKRETSRLSWTQVSTE------ 24855

Query: 369   MVVRSHARVSSLTLKSIQYTDAGEYI--CTASNTIGQDSQSMYLEVQYAPKLQGPVAV-- 424
                     V +L  K  +     EYI    A N  G             P   GPV    
Sbjct: 24856 --------VQALNYKVTKLLPGNEYIFRVMAVNKYGIGE----------PLESGPVTACN 24897

Query: 425   -YTWEGNQVNITCEVFAYPSATISWFR---------DGQLLPSSNYSNIK----IYNTPS 470
              Y   G             S  ++W R         +G +L   +   ++       T +
Sbjct: 24898 PYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLT 24957

Query: 471   ASYLEVTPDSENDFGNYNCTAVNR--IGQESLEFILVQA-------DTPSSPSIDQVEPY 521
                L VT  +E     +   A N   +G+ S   +  +A         PS+P +   +  
Sbjct: 24958 DLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKV--TDTS 25015

Query: 522   SSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG-IVTIVGLKPET 580
              S+  + + +P   GG P+  Y  E +    + W +         ++G   T+  LK  T
Sbjct: 25016 RSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTT---CTPPTGLQGKQFTVTKLKENT 25072

Query: 581   TYAVRLAALNGKGLGE 596
              Y  R+ A+N +G+GE
Sbjct: 25073 EYNFRICAINSEGVGE 25088



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 121/531 (22%), Positives = 204/531 (38%), Gaps = 68/531 (12%)

Query: 197   GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
             G I  KD   +  +    + R  IV    N G++  L  D  G P PT+ W +  ++IE+
Sbjct: 23612 GPITAKDEVELPRISMDPKFRDTIV---VNAGETFRLEADVHGKPLPTIEWLRGDKEIEE 23668

Query: 257   EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
                 E    +D  + L +K   + D  +YI  A N AG +   +++KV  +P        
Sbjct: 23669 SARCE-IKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRP-------- 23719

Query: 317   TAMELEEQVT-LTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHA 375
                E   QVT +T E       S+TW    ++  S+   S    EK+ET      V + +
Sbjct: 23720 GPPEGPVQVTGVTSEKC-----SLTWSPPLQDGGSD--ISHYVVEKRETSRLAWTVVA-S 23771

Query: 376   RVSSLTLKSIQYTDAGEYI--CTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVN 433
              V + +LK  +  +  EY+    A N  G         ++ AP L     V       + 
Sbjct: 23772 EVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGE-----PLESAPVLMKNPFVLPGPPKSLE 23826

Query: 434   ITCEVFAYPSATISWFRD---------GQLLPSSNYSNIKIYNTPSASY----LEVTPDS 480
             +T    A  S T+ W R          G ++   + S I+             L VT  +
Sbjct: 23827 VT--NIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLT 23884

Query: 481   ENDFGNYNCTAVNR--IGQESLEFILVQADTP-----SSPSIDQVEPYSSTAQVQFDEPE 533
             E+    +  +A N   +G+ S   +  +A  P        +   V+   ++  + + +P 
Sbjct: 23885 EDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPI 23944

Query: 534   ATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG 593
               GG  IL Y  E     EE W  +    +         I  L     Y +R+ ALN  G
Sbjct: 23945 YDGGSEILGYVVEICKADEEEW--QIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVG 24002

Query: 594   LGEISAASEFKTQPVQGEPSAPKLE-------GQMGEDGNSIKVNLIKQDDGGSPIRHYL 646
             LGE  A S   T   + +  AP+L+       G +   G S ++++  +   G P     
Sbjct: 24003 LGE--ATSVPGTVKPEDKLEAPELDLDSELRKGIVVRAGGSARIHIPFK---GRPTPE-- 24055

Query: 647   VRYRALSSEWKPEIRLPSGSDHVMLK--SLDWNAEYEVYVVAENQQGKSKA 695
             + +     E+  ++++  G ++  L   + D N   +  +  EN  G   A
Sbjct: 24056 ITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSA 24106



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 80/363 (22%), Positives = 139/363 (38%), Gaps = 27/363 (7%)

Query: 370   VVRSHARVSSLTLKSIQYTDAGEYICTASNTIG--QDSQSMYLEVQYAPKLQGPVAVYTW 427
             V   H +  + T++ +      E+   A N  G  +  ++    +   P+++ P A  T 
Sbjct: 28593 VEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIE-PTADLTG 28651

Query: 428   EGNQVNITCE----------VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVT 477
               NQ+ ITC+          +   P+  ++W  +   L  ++   + I  T   + L V 
Sbjct: 28652 ITNQL-ITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETD--RVSITTTKDRTTLTVK 28708

Query: 478   PDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEA 534
                  D G Y  T  N  G ++    +V    P  P    +E  S +A+   + + EP+ 
Sbjct: 28709 DSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPG-PVTGPIEVSSVSAESCVLSWGEPKD 28767

Query: 535   TGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGL 594
              GG  I  Y  E R  G   W       K   ++    +  L     Y+ R+++ N  G+
Sbjct: 28768 GGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIK----VTHLTKYMEYSFRVSSENRFGV 28823

Query: 595   GEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRALS 653
              +   ++    +     PSAP          N++ +   +   DGGS I  Y V  +  +
Sbjct: 28824 SKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERN 28883

Query: 654   SE-WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 712
             +  W  E ++P    +  +  L    EY+    A N  G SKA+       AQ   + A 
Sbjct: 28884 TILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQ-NPVDAP 28942

Query: 713   GSP 715
             G P
Sbjct: 28943 GRP 28945



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 62/306 (20%), Positives = 122/306 (39%), Gaps = 36/306 (11%)

Query: 16    TAVSLQVDIVPSQGEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVW 73
             T   +++D      +++V E +   F C +  +A   ++ W    G  +  +  +  ++ 
Sbjct: 11480 TVKEIELDFAVPLKDVTVPERRQARFECVLTREA---NVIW--SKGPDIIKSSDKFDII- 11533

Query: 74    NDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGE 133
              D     L I ++  DD G+Y   V G+  S       ++    L F +    Q  +EGE
Sbjct: 11534 ADGKKHILVINDSQFDDEGVYTAEVEGKKTSARLFVTGIR----LKFMSPLEDQTVKEGE 11589

Query: 134   DAVIVCDVVSSLPPTIIWK-----HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYR 188
              A  VC++       + +K     H  R V++  + +      + L+++ +   D    +
Sbjct: 11590 TATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGK-----THKLEMKEVTLDDISQIK 11644

Query: 189   CEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWT 248
              + +     E++      ++   P    + +  + TA     +TL C+     +  + W 
Sbjct: 11645 AQVK-----ELSSTAQLKVLEADPYFTVKLH--DKTAVEKDEITLKCEVS--KDVPVKWF 11695

Query: 249   KDGEQIEQEEDDEKYIFSDDSSQ--LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306
             KDGE+I       KY    D  +  L IKK D  D+ EY+C       + + T+  ++  
Sbjct: 11696 KDGEEIVPSP---KYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIK 11752

Query: 307   KPKITY 312
               K  Y
Sbjct: 11753 VEKPLY 11758



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 88/372 (23%), Positives = 153/372 (41%), Gaps = 51/372 (13%)

Query: 351   EEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYL 410
             E K +WT+ +     D  + + +  + S++T+   + +D G YI  A N  G+ +  + +
Sbjct: 13719 EPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEV 13778

Query: 411   EVQYAPKLQGPVAVY------------TWE------GNQV-NITCEVFAYPSATISWFRD 451
              V   P   GP A +            TW       G+++ N   E  A  S    W + 
Sbjct: 13779 NVLDKP---GPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEV--WHKL 13833

Query: 452   GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 511
                +  +N+   K+   P+  Y+     +EN +G      V    Q S      Q D P 
Sbjct: 13834 SSTVKDTNFKATKL--IPNKEYI-FRVAAENMYG------VGEPVQASPITAKYQFDPPG 13884

Query: 512   SPSIDQVEPYSST---AQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME 568
              P+  ++EP   T     + + EP+  GG PI  Y  E      +    KW    +  ++
Sbjct: 13885 PPT--RLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTD----KWVRCNKMPVK 13938

Query: 569   GIV-TIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDG-N 626
                  + GL  +  Y  R+ A N  G G+ S ++E        +P  P  +  + + G  
Sbjct: 13939 DTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKT 13998

Query: 627   SIKVNLIK-QDDGGSPIRHYLVR-YRALSSEWKPEIRLPSG--SDHVMLKSLDWNAEYEV 682
             S+++N  K + DGG+ I  Y++   +  + EW   +R+  G  +   +L  L    EY  
Sbjct: 13999 SVRLNWTKPEHDGGAKIESYVIEMLKTGTDEW---VRVAEGVPTTQHLLPGLMEGQEYSF 14055

Query: 683   YVVAENQQGKSK 694
              V A N+ G+S+
Sbjct: 14056 RVRAVNKAGESE 14067



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 68/275 (24%), Positives = 117/275 (42%), Gaps = 29/275 (10%)

Query: 429   GNQVNITCEVFAYPSATISWFR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDSEN--DFG 485
             G  + +   +   P+  + W + DG++  ++           ++S+  +  D+ N  D G
Sbjct: 22957 GGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIID-------VTSSFTSLVLDNVNRYDSG 23009

Query: 486   NYNCTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYK 544
              Y  T  N  G +S    +   DTPS P ++   E    +  + ++ P   GG  I  Y 
Sbjct: 23010 KYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYI 23069

Query: 545   AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLG-EISAASEF 603
              E R    + + +   +  + S +    I  L+   +Y  R+ A N  G+G     A   
Sbjct: 23070 VEKREATRKSYAAVVTNCHKNSWK----IDQLQEGCSYYFRVTAENEYGIGLPAQTADPI 23125

Query: 604   KTQPVQGEPSAPKLEGQMGEDG---NSIKVNLIK-QDDGGSPIRHYLVRYRALSSE-WKP 658
             K   V      P+  G++  D    NS+ ++  K + DGGS I  Y+V  +A  SE W  
Sbjct: 23126 KVAEV------PQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSE 23179

Query: 659   EIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 693
               R+   S   ++ +L    EY   VVA N++G+S
Sbjct: 23180 CARVK--SLQAVITNLTQGEEYLFRVVAVNEKGRS 23212



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 83/366 (22%), Positives = 137/366 (37%), Gaps = 59/366 (16%)

Query: 270   SQLTIKKVDKNDEAEYICIAENKAGEQDAT-IHLKVFAKPKITYVENQTAMELEEQVTLT 328
             ++  I K+ ++ E +    A NK G  +AT +   V  + K+   E     EL + + + 
Sbjct: 23978 TRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIVVR 24037

Query: 329   CEAS--------GDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSL 380
                S        G P P ITW        S E+  +T           + +      + L
Sbjct: 24038 AGGSARIHIPFKGRPTPEITW--------SREEGEFT---------DKVQIEKGVNYTQL 24080

Query: 381   TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP---------KLQGPVAVYTWEGNQ 431
             ++ +    DAG+YI    N+ G  S  + ++V   P         +++   A   WE   
Sbjct: 24081 SIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPI 24140

Query: 432   VNITCEVFAYPSATISWFRDGQLLPSSNYS--NIKIYNTPSASYLEVTPDSENDFGNYNC 489
             ++   +V  Y        R      SS  S  + K+ N    +       +EN+FG    
Sbjct: 24141 IDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFG---- 24196

Query: 490   TAVNRIGQESLEFILVQADTPSSP--SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 547
                  +G        V+A  P SP   +   +   ++A + +++PE  GG  +L Y  E 
Sbjct: 24197 -----VGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEM 24251

Query: 548   RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG------LGEISAAS 601
             +  G E    KW    E+ +   V + GL     Y  R+ A N KG      LG    A 
Sbjct: 24252 QPKGTE----KWSIVAESKVCNAV-VTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAK 24306

Query: 602   EFKTQP 607
             +   QP
Sbjct: 24307 DLTIQP 24312



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 98/409 (23%), Positives = 151/409 (36%), Gaps = 41/409 (10%)

Query: 228   GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
             G SV L     G P PT+ W KD +++ Q         + D + + IK  D+ +   Y  
Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKEL-QTNALVCVENTTDLASILIKDADRLNSGCYEL 26945

Query: 288   IAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347
                N  G   ATI +++  KP       +      E++TL      D             
Sbjct: 26946 KLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPAD------------- 26992

Query: 348   ISSEEKASWTRPEKQETLD-GHMVVRSHARVSSLTLKSIQYTDAGEYI----CTASNTIG 402
                  K +    EK+ET      +V  H     +T   I      EYI          IG
Sbjct: 26993 -DGGAKITHYIVEKRETSRVVWSMVSEHLEECIITTTKI--IKGNEYIFRVRAVNKYGIG 27049

Query: 403   QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSN 462
             +  +S  +  + A    GP  +        N    V++ P A       G  L   +  +
Sbjct: 27050 EPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKS 27109

Query: 463   I----KIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ----ESLEFILV--QADTPSS 512
             +     +  T   +  +VT  +EN    Y   AVN  GQ    E  EF       D P  
Sbjct: 27110 LGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGP 27169

Query: 513   PS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIV 571
             P+ I   +   S+  + + +P   GG  +  Y  E R   EE W +     +  + E +V
Sbjct: 27170 PAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVV 27229

Query: 572   TIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEP--SAPKLE 618
             +   LKP   Y  R++A+N  G GE    +E    PVQ +    AP+++
Sbjct: 27230 S--NLKPGVNYYFRVSAVNCAGQGEPIEMNE----PVQAKDILEAPEID 27272



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 87/412 (21%), Positives = 152/412 (36%), Gaps = 50/412 (12%)

Query: 81   LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
            LT+ +   +D G Y  V+   DG ++   + +K  + +      + Q+  EG+  ++  +
Sbjct: 2323 LTVKDVTKEDQGEYSFVI---DGKKTTCKLKMKP-RPIAILQGLSDQKVCEGD--IVQLE 2376

Query: 141  VVSSLPPTI-IWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILA--- 195
            V  SL     +W   G++V     V  ++   ++ L I  + K D G Y      L    
Sbjct: 2377 VKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLST 2436

Query: 196  RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
             G ++   + VI  +        N++  T        L C        ++ W  + EQI+
Sbjct: 2437 SGRVSVYSVDVITPLKDV-----NVIEGT-----KAVLECKVSVPDVTSVKWYLNDEQIK 2486

Query: 256  QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
             + D  + I      +L I +   +DE  Y  I     G  +   +L V     I  + +
Sbjct: 2487 PD-DRVQAIVKGTKQRLVINRTHASDEGPYKLIV----GRVETNCNLSVEKIKIIRGLRD 2541

Query: 316  QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHA 375
             T  E +  V    E S   I  + W    + I    K                 + +H 
Sbjct: 2542 LTCTETQN-VVFEVELSHSGI-DVLWNFKDKEIKPSSKYK---------------IEAHG 2584

Query: 376  RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNIT 435
            ++  LT+ ++   D G+Y   A   +     ++       P     VA    E  +    
Sbjct: 2585 KIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPLTDQTVA----ESQEAVFE 2640

Query: 436  CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 487
            CEV A P +   W RDG+ LP +N  NI+  +      L +     +D G Y
Sbjct: 2641 CEV-ANPDSKGEWLRDGKHLPLTN--NIRSESDGHKRRLIIAATKLDDIGEY 2689



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 97/403 (24%), Positives = 162/403 (40%), Gaps = 65/403 (16%)

Query: 323   EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTL 382
             E   +  +  G PIP+I W    + +S+  +               + ++S    +SL++
Sbjct: 22559 ESFKVDADIYGKPIPTIQWIKGDQELSNTAR---------------LEIKSTDFATSLSV 22603

Query: 383   KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAY 441
             K     D+G YI  A N  G+ S ++ ++V   P   +GPV +         +T E    
Sbjct: 22604 KDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVI-------SGVTAE---- 22652

Query: 442   PSATISW---FRDG-----QLLPSSNYSNIKIYNTPSASY----LEVTPDSENDFGNYNC 489
                T++W    +DG       +     ++  ++    A+      +VT   E +   +  
Sbjct: 22653 -KCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRI 22711

Query: 490   TAVNRIG-QESLEFILVQA-------DTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPIL 541
              AVN+ G  E LE   V A       D P +P +  V   S    V ++ P + GG  IL
Sbjct: 22712 MAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMI--VVWERPASDGGSEIL 22769

Query: 542   KYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAAS 601
              Y  E R      W       K    E  + + GL     Y  R++A N  GL E S  S
Sbjct: 22770 GYVLEKRDKEGIRWTR---CHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPS 22826

Query: 602   EFK--TQPV--QGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRALS-SE 655
              ++    P+   G P+ PK+   +    +S+ ++  K   DGG  I+ Y+V    +S  E
Sbjct: 22827 AYQKACDPIYKPGPPNNPKV---IDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGE 22883

Query: 656   WKPEIRLPSG--SDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 696
             W      P+G    ++ ++ L    EY   + A N+ G  + A
Sbjct: 22884 W-TMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHA 22925



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 79/355 (22%), Positives = 131/355 (36%), Gaps = 42/355 (11%)

Query: 246   SWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF 305
             +W KDG  I +E    ++I      +L I  V  +D  EY C+      E+ +T  L V 
Sbjct: 11150 TWMKDGSNI-RESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVE 11208

Query: 306   AKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETL 365
               P + +V+      LEE+VT+     G P+        +  ++ E    W +       
Sbjct: 11209 ELP-VRFVKT-----LEEEVTV---VKGQPL------YLSCELNKERDVVWRK------- 11246

Query: 366   DGHMVVRSHARV--------SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK 417
             DG +VV    R+         +LT+     TDAG Y  T  N    +  S    V+    
Sbjct: 11247 DGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRD 11306

Query: 418   -LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEV 476
              L  P+     +     I     A  +  I WF+    +P+      +I    +  YL++
Sbjct: 11307 WLVKPIRDQHVKPKGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKI 11366

Query: 477   TPDSENDFGNYNCTAVNRIGQE-SLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEAT 535
                   D   Y   AV   G+    +  L + +      I+ V  Y   +   FD   + 
Sbjct: 11367 KNAMPEDIAEY---AVEIEGKRYPAKLTLGEREVELLKPIEDVTIYEKES-ASFDAEISE 11422

Query: 536   GGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 590
               +P      +W+  GE +  S   + K    +  +T+  +K +    V   ALN
Sbjct: 11423 ADIP-----GQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALN 11472



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 98/473 (20%), Positives = 195/473 (41%), Gaps = 74/473 (15%)

Query: 35    ESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSS-TLTIYNANIDDAGI 93
             ES  F  +++ D  +  + WF  N ++L   +   SV   D+  + ++T  + +IDD   
Sbjct: 11944 ESAVFTVELSHD--NIRVKWFK-NDQRLHTTR---SVSMQDEGKTHSITFKDLSIDDTSQ 11997

Query: 94    YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
              +    G   SE++ TV   +     F          E ++ ++ C++  +  P + W  
Sbjct: 11998 IRVEAMGMS-SEAKLTV---LEGDPYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFK 12052

Query: 154   KGRDV------ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-GRILARGEINFKDIQV 206
              G+++      ++K D +        L ++   K+D G Y C+ G     G+++ +D ++
Sbjct: 12053 DGKEIKPSKNAVIKADGK-----KRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREI 12107

Query: 207   IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE-KYIF 265
              +  P  + + + +   TA     ++         +   +W   GE + Q  D E K   
Sbjct: 12108 KLVRP--LHSVEVMETETARFETEISE-------DDIHANWKLKGEALLQTPDCEIKEEG 12158

Query: 266   SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN---QTAMELE 322
                S  L   ++D+    ++      +A    ++ HL+V  KP++  +        +   
Sbjct: 12159 KIHSLVLHNCRLDQTGGVDF------QAANVKSSAHLRV--KPRVIGLLRPLKDVTVTAG 12210

Query: 323   EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTL 382
             E  T  CE S + IP + W    + +   +K               +V RS  +V +LTL
Sbjct: 12211 ETATFDCELSYEDIP-VEWYLKGKKLEPSDK---------------VVPRSEGKVHTLTL 12254

Query: 383   KSIQYTDAGEYICTASNTIGQDSQSMYLE---VQYAPKLQGPVAVYTWEGNQVNITCEVF 439
             + ++  DAGE   TA +   +   +++++   V++   L+        EG    + CEV 
Sbjct: 12255 RDVKLEDAGEVQLTAKDF--KTHANLFVKEPPVEFTKPLEDQTVE---EGATAVLECEV- 12308

Query: 440   AYPSATISWFRDG-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 491
             +  +A + WF++G ++L S  Y  +           + TP+   D   Y C A
Sbjct: 12309 SRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPE---DIKTYTCDA 12358



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 9/113 (7%)

Query: 199   INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
             +  KDI     +   +  R +++   A  G+ V ++   +G P PT++W KD + +    
Sbjct: 27260 VQAKDILEAPEIDLDVALRTSVI---AKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGS-- 27314

Query: 259   DDEKYIF--SDDSSQLTIKKVDKNDEAEYICIAENKAGE-QDATIHLKVFAKP 308
              D +Y    +D SS LTI +V +ND  +YI   EN  GE + +T+ +KV   P
Sbjct: 27315 -DARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTP 27366



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 84/373 (22%), Positives = 150/373 (40%), Gaps = 50/373 (13%)

Query: 351   EEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYL 410
             E K  WT+ +K+  L   + ++   + ++  +K    +D+G+Y  T  N  G  + S+ +
Sbjct: 29076 EPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMV 29135

Query: 411   EVQYAPKLQGPVAV---------YTWEGNQVNITCEVFAY-----PSATISWFRDGQLLP 456
             +V  +P   G + V           W   Q +   E+  Y      ++ ++W        
Sbjct: 29136 KVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWV------- 29188

Query: 457   SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ----ESLEFILVQADT-PS 511
                   I     P+ SY+ VT   +N+   +   AVN+ G     ES   +   + T PS
Sbjct: 29189 ------IVEGECPTLSYV-VTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPS 29241

Query: 512   SPSI-DQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWH--SKWYDAKEASME 568
              P I ++V        +Q+ +PE+ GG  I  Y  + R      W   +K Y   +  ++
Sbjct: 29242 PPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLK 29301

Query: 569   GIVTIVGLKPETTYAVRLAALNGKGLGEISAASEF----KTQPVQGEPSAPKLEGQMGED 624
                 +  L     Y  R+ A+N  G  E S AS F    +     G PSAP++   +   
Sbjct: 29302 ----VTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRV---VDTT 29354

Query: 625   GNSIKVNLIK-QDDGGSPIRHYLVRYRALSSE--WKPEIRLPSGSDHVMLKSLDWNAEYE 681
              +SI +   K   DGG+ I  Y++  +   ++  ++        +    +  L    +Y 
Sbjct: 29355 KHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYS 29414

Query: 682   VYVVAENQQGKSK 694
               V A N +G S+
Sbjct: 29415 FRVAAVNVKGMSE 29427



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 27/81 (33%), Positives = 44/81 (54%), Gaps = 1/81 (1%)

Query: 228   GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
             G+ + +  D  G P P +SW KDG +IE+    E  I +D+ + LT+K   + D  +Y+ 
Sbjct: 25804 GEVLKINADIAGRPLPVISWAKDGIEIEERARTE-IISTDNHTLLTVKDCIRRDTGQYVL 25862

Query: 288   IAENKAGEQDATIHLKVFAKP 308
               +N AG +   ++ KV  KP
Sbjct: 25863 TLKNVAGTRSVAVNCKVLDKP 25883



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 126/595 (21%), Positives = 212/595 (35%), Gaps = 97/595 (16%)

Query: 147   PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQV 206
             P ++W     D+  +  V     S   L I    + D G Y     +  +  ++   + +
Sbjct: 26216 PNVLWSKPDTDLRTRAYVD-TTDSRTSLTIENANRNDSGKYT----LTIQNVLSAASLTL 26270

Query: 207   IVNV-----PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE 261
             +V V     PPT    Q++   +A L   V         PE           IE+ E  +
Sbjct: 26271 VVKVLDTPGPPTNITVQDVTKESAVLSWDV---------PENDGGAPVKNYHIEKREASK 26321

Query: 262   KYIFS--DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
             K   S  ++ ++L+ K  +  + A Y       +GE +  + +    K  +   E     
Sbjct: 26322 KAWVSVTNNCNRLSYKVTNLQEGAIYYF---RVSGENEFGVGIPAETKEGVKITEK---- 26374

Query: 320   ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKA-SWTRPEKQETLDG-----HMVVRS 373
                              PS   +    +IS +  + +W +PE     DG     H VV +
Sbjct: 26375 -----------------PSPPEKLGVTSISKDSVSLTWLKPEH----DGGSRIVHYVVEA 26413

Query: 374   HAR-----VSSLTLKSIQYTDAG-----EYICT--ASNTIG-QDSQSMYLEVQYAPKLQG 420
               +     V     KS  +  +G     EY     A N  G  D + + L V    +L+ 
Sbjct: 26414 LEKGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEP 26473

Query: 421   PV---------AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSA 471
             P           VY   G+ + +   +   P   ++  RDG  L ++   N +I  T   
Sbjct: 26474 PEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEI--TAEN 26531

Query: 472   SYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS----IDQVEPYSSTAQV 527
               + +      D G Y  TA N  G       +V  D P  P+    I  +   S T  +
Sbjct: 26532 LTINLKESVTADAGRYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESVT--L 26589

Query: 528   QFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLA 587
             +++ P+  GG  +  Y    R     VW     +        ++ ++ L     Y  R+ 
Sbjct: 26590 KWEPPKYDGGSQVTNYILLKRETSTAVWT----EVSATVARTMMKVMKLTTGEEYQFRIK 26645

Query: 588   ALNGKGLGE-ISAASEFKTQP--VQGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIR 643
             A N  G+ + I +A      P    G PS P +     E   SI V   +   +GGS + 
Sbjct: 26646 AENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRE---SITVGWHEPVSNGGSAVV 26702

Query: 644   HYLVRYRALSSE-WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAH 697
              Y +  +  +S  W+   +L   + H  + ++     YE  V AEN  G  K +H
Sbjct: 26703 GYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSH 26757



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 95/462 (20%), Positives = 169/462 (36%), Gaps = 55/462 (11%)

Query: 256   QEEDDEKYIFSDDSS--QLTIKKVDKNDEAEYICIAENKAGEQDATI-HLKVFAK----- 307
             Q +  EK+    +S      +  +    E ++   A N+ G+ D  +  + V AK     
Sbjct: 24252 QPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQ 24311

Query: 308   PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDG 367
             P +    N  +++  E + +     G P P+I+W         E     TR   +ET   
Sbjct: 24312 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKD-----GEPLKQTTRVNVEET--- 24363

Query: 368   HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP----------K 417
                    A  + L +K     D G+Y  TA+N+ G  ++++ + V   P          +
Sbjct: 24364 -------ATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDE 24416

Query: 418   LQGPVAVYTWEGNQVNITCEVFAY-----PSATISWFRDGQLLPSSNYSNIKIYNTPSAS 472
             +     V +WE       C++  Y      + T +W     +  +   + IKI    + +
Sbjct: 24417 VSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTWH---MVSATVARTTIKITKLKTGT 24473

Query: 473   YLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEP 532
               +    +EN +G    +A        +++   +   P +P +  +        VQ+ EP
Sbjct: 24474 EYQFRIFAENRYGK---SAPLDSKAVIVQYPFKEPGPPGTPFVTSIS--KDQMLVQWHEP 24528

Query: 533   EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGK 592
                GG  I+ Y  E +     +W       K    +      GL     Y  +++A N  
Sbjct: 24529 VNDGGTKIIGYHLEQKEKNSILWVKL---NKTPIQDTKFKTTGLDEGLEYEFKVSAENIV 24585

Query: 593   GLGEISAASE-FKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYR 650
             G+G+ S  SE F  +     P  P+    +    N++ +   K   DGGS I  Y+V  +
Sbjct: 24586 GIGKPSKVSECFVARDPCDPPGRPE---AIVITRNNVTLKWKKPAYDGGSKITGYIVEKK 24642

Query: 651   AL-SSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 691
              L    W              +  L  +  YE  V+A N  G
Sbjct: 24643 DLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAG 24684



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 69/280 (24%), Positives = 109/280 (38%), Gaps = 40/280 (14%)

Query: 354   ASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 413
             A W++P+   +L     + +    S+LT+++    DAG+Y  T  N  G  S +  ++V 
Sbjct: 28389 AVWSKPDSNLSLRAD--IHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITFTVKVL 28446

Query: 414   YAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASY 473
               P   GP            IT +     SAT+ W  D  LL      +  +     AS 
Sbjct: 28447 DTPGPPGP------------ITFKDVTRGSATLMW--DAPLLDGGARIHHYVVEKREASR 28492

Query: 474   LEVTPDSE---------NDFGN-----YNCTAVNRIG---QESLEFILVQADTPSSP-SI 515
                   SE         ND        +  +AVN  G      +   +V  + P+ P  +
Sbjct: 28493 RSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRL 28552

Query: 516   DQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVG 575
             D V+   S+A + + +P+  GG  I  Y  E R  G + W    +     + +   T+  
Sbjct: 28553 DVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGH-----TKQLTFTVER 28607

Query: 576   LKPETTYAVRLAALNGKGLGE-ISAASEFKTQPVQGEPSA 614
             L  +T Y  R+ A N  G  E   A S    +  Q EP+A
Sbjct: 28608 LVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTA 28647



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 47/182 (25%), Positives = 83/182 (45%), Gaps = 13/182 (7%)

Query: 131   EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKK---DVRFIVLSNNY-LQIRGIKKTDEGT 186
             +G   ++   V    P T  W    +D ++++    V  ++  N Y  +I+      EG 
Sbjct: 17830 DGGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEG- 17888

Query: 187   YRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMS 246
                E R LA   I  KDI     V   +  R  I   T  +GQ++ ++   +G PEP ++
Sbjct: 17889 ---EPRELAESVIA-KDILHPPEVELDVTCRDVI---TVRVGQTIRILARVKGRPEPDIT 17941

Query: 247   WTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306
             WTK+G+ + +E+  +  I      +L IK+  + D  +YI  A+N +G    +  + V  
Sbjct: 17942 WTKEGKVLVREKRVD-LIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLD 18000

Query: 307   KP 308
             +P
Sbjct: 18001 RP 18002



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 88/389 (22%), Positives = 148/389 (38%), Gaps = 45/389 (11%)

Query: 325   VTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKS 384
             V L    SG P P+I                W + +K+   +  + V +   ++S+ +K 
Sbjct: 26890 VKLRAGISGKPAPTI---------------EWYKDDKELQTNALVCVENTTDLASILIKD 26934

Query: 385   IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG-PVAVYTWEGNQVNITCEVFAYPS 443
                 ++G Y     N +G  S ++ +++   P   G P+   T    ++ +       P 
Sbjct: 26935 ADRLNSGCYELKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWR----PP 26990

Query: 444   ATISWFRDGQLLPSSNYSNIKIYNTPSASYLE-VTPDSENDFGN---YNCTAVNRIG-QE 498
             A     +    +     ++  +++  S    E +   ++   GN   +   AVN+ G  E
Sbjct: 26991 ADDGGAKITHYIVEKRETSRVVWSMVSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGE 27050

Query: 499   SLEFILVQAD----TPSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPILKYKAEWRAVGEE 553
              LE   V A     TP  P I +V   +  +  V +  P A GG  I  Y  E R     
Sbjct: 27051 PLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSL 27110

Query: 554   VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPS 613
              W       KE   +    + GL   + Y  R+ A+N  G G  S  SEF       +P 
Sbjct: 27111 GWFKV---LKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPP 27167

Query: 614   APKLEGQMGED-GNSIKVNLIKQ-DDGGSPIRHYLVRYR-ALSSEW-----KPEIRLPSG 665
              P  + ++ +   +SI +   K   DGGS +  Y+V  R     EW     K E+R    
Sbjct: 27168 GPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVR---- 27223

Query: 666   SDHVMLKSLDWNAEYEVYVVAENQQGKSK 694
             +   ++ +L     Y   V A N  G+ +
Sbjct: 27224 TTEYVVSNLKPGVNYYFRVSAVNCAGQGE 27252



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 47/205 (22%), Positives = 89/205 (43%), Gaps = 13/205 (6%)

Query: 415 APKLQGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASY 473
           AP    P+ +V   EG+       +  +P   +SWFRDGQ++ +S    ++I  +   + 
Sbjct: 5   APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64

Query: 474 LEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQADTPSSPSIDQVEPYS--STAQVQFD 530
           L +   ++ + G Y+  A N  GQ  S   +LV+A+T     + +++  +    +QV+  
Sbjct: 65  LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ 124

Query: 531 EPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 590
                   P++K+  +    G E+  S  +   +      + I    PE +    + A N
Sbjct: 125 VRVTGIPTPVVKFYRD----GAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATN 180

Query: 591 GKGLGEISAASEFKTQPVQGEPSAP 615
              +G  ++ +E     VQGE   P
Sbjct: 181 --SVGRATSTAELL---VQGEEEVP 200



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 109/521 (20%), Positives = 185/521 (35%), Gaps = 64/521 (12%)

Query: 199   INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
             I  KD  V  ++      R  IV    + G  + ++    G P PT++W  +   + QE 
Sbjct: 16513 IEMKDRLVSPDLQLDASVRDRIV---VHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEA 16569

Query: 259   DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
               E    S   S + IK   ++ +  Y  +A+N+AGE+  TI + V   P          
Sbjct: 16570 TIETTAIS---SSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAH 16626

Query: 319   MELEEQVTLTC----EASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSH 374
                 E   LT     +  G PI +             ++ +WT          + V R +
Sbjct: 16627 NLTNESCKLTWFSPEDDGGSPITNYVIEK-----RESDRRAWTPVT-------YTVTRQN 16674

Query: 375   ARVSSLTLKSIQYTDAGEYICTASNTIG-----QDSQSMYL-EVQYAPKLQGPVAVYTWE 428
             A V  L      +     +   A N+IG     + S+++ + E    P+    + V    
Sbjct: 16675 ATVQGLIQGKAYF-----FRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVT 16729

Query: 429   GNQVNITCEVFAYP--SATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN 486
              N V +T     Y   S  I++  + +L+ +  +  +   N  S  Y  V    E D   
Sbjct: 16730 KNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKY-TVKGLKEGDTYE 16788

Query: 487   YNCTAVNRIGQESLEFI---LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKY 543
             Y  +AVN +GQ    F    +   D  + P++     +     ++  E  A  G      
Sbjct: 16789 YRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHL--DFRDKLTIRVGEAFALTG------ 16840

Query: 544   KAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL---NGK-------G 593
                 R  G+      W+  +   +E   T +   P T    ++ A    +GK        
Sbjct: 16841 ----RYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENS 16896

Query: 594   LGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALS 653
              G      +       G P  P    ++ +D   I       DDGGS I +Y++  + + 
Sbjct: 16897 TGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWK-PPLDDGGSKITNYIIEKKEVG 16955

Query: 654   SE-WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 693
              + W P +   S      +  L    +Y   + AEN  G S
Sbjct: 16956 KDVWMP-VTSASAKTTCKVSKLLEGKDYIFRIHAENLYGIS 16995



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 103/478 (21%), Positives = 171/478 (35%), Gaps = 42/478 (8%)

Query: 231   VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAE 290
             +T++  + G+P PT +W   G+++ +  D  K       ++L I   +++D+  Y    E
Sbjct: 13412 ITILVPSTGYPRPTATWC-FGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLE 13470

Query: 291   NKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDP--IPSITWRTSTRNI 348
             N+       I + V A+P     E +     ++ V LT E   D    P   +    R +
Sbjct: 13471 NRVKTISGEIDVNVIARPSAP-KELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREV 13529

Query: 349   SSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYI--CTASNTIGQDSQ 406
             S   + +WT+      +D          V+ L           EY+    A N  G    
Sbjct: 13530 S---RKTWTK-----VMD---------FVTDLEFTVPDLVQGKEYLFKVCARNKCGPGEP 13572

Query: 407   SMY---LEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLL---PSSNY 460
             +     + +     +  P     W     N     +  P         G ++   P  + 
Sbjct: 13573 AYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSD 13632

Query: 461   SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG--QESLEFILVQA-DTPSSPSI-- 515
               +      + + +EVT   E  +  Y   A+NR G  + S     +QA DT  +P I  
Sbjct: 13633 KWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFL 13692

Query: 516   --DQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTI 573
                 +   +  A  + + P    G P  + K  W      +   K    +    +  VTI
Sbjct: 13693 DVKLLAGLTVKAGTKIELPATVTGKP--EPKITWTKADMILKQDKRITIENVPKKSTVTI 13750

Query: 574   VGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLI 633
             V  K   T    + A+N    G  +A  E       G P+A  +     E  + +     
Sbjct: 13751 VDSKRSDTGTYIIEAVN--VCGRATAVVEVNVLDKPGPPAAFDITDVTNE--SCLLTWNP 13806

Query: 634   KQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 691
              +DDGGS I +Y+V  RA  SE   ++       +     L  N EY   V AEN  G
Sbjct: 13807 PRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYG 13864



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 101/467 (21%), Positives = 175/467 (37%), Gaps = 75/467 (16%)

Query: 269   SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA-----KPKITYVE--NQTAMEL 321
             S + T+K + + D  EY   A N  G+   +   K         P   +++  ++  + +
Sbjct: 16773 SRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRV 16832

Query: 322   EEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLT 381
              E   LT   SG P P ++W     ++  ++                   R+H + +  T
Sbjct: 16833 GEAFALTGRYSGKPKPKVSWFKDEADVLEDD-------------------RTHIKTTPAT 16873

Query: 382   LK----SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCE 437
             L       + +D+G+Y     N+ G  S+  + +V    +   PV   +++     +T +
Sbjct: 16874 LALEKIKAKRSDSGKYCVVVENSTG--SRKGFCQVNVVDRPGPPVGPVSFD----EVTKD 16927

Query: 438   VFAYPSATISW---FRDGQLLPSSNYSNIK----------IYNTPSASYLEVTPDSENDF 484
                     ISW     DG     +NY   K          + +  + +  +V+   E   
Sbjct: 16928 YMV-----ISWKPPLDDGGS-KITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKD 16981

Query: 485   GNYNCTAVNRIG-QESLEFILVQA-------DTPSSPSIDQVEPYSSTAQVQFDEPEATG 536
               +   A N  G  + L    ++A       D P  P + +V     +A V +++P   G
Sbjct: 16982 YIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVT--KDSALVTWNKPH-DG 17038

Query: 537   GVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 596
             G PI  Y  E R    + W     D      +    +  L     Y  R++A N  G+G+
Sbjct: 17039 GKPITNYILEKRETMSKRWARVTKDPIHPYTK--FRVPDLLEGCQYEFRVSAENEIGIGD 17096

Query: 597   ISAASE--FKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLVRYRAL- 652
              S  S+  F   P+  +PS P     +    NS+ +     + DGGS I  Y+V Y+ + 
Sbjct: 17097 PSPPSKPVFAKDPI-AKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVG 17155

Query: 653   SSEWKPEIRLPSGSDHVMLK--SLDWNAEYEVYVVAENQQGKSKAAH 697
               EW+     P        K   L     Y+  V+A N  G+S  AH
Sbjct: 17156 DEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAH 17202



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 39/147 (26%), Positives = 66/147 (44%), Gaps = 21/147 (14%)

Query: 224   TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEA 283
             T   G S+ L+    G P P ++W+K G  +      +    ++  S L + KV++ D  
Sbjct: 29457 TIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDT---TESYSLLIVDKVNRYDAG 29513

Query: 284   EYICIAENKAGEQDATIHLKVFAKP------KITYVENQTAMELEEQVTLTCEASGDPIP 337
             +Y   AEN++G++ AT+ +KV+  P      K+  V         + VT+T E     IP
Sbjct: 29514 KYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVS-------RDSVTITWE-----IP 29561

Query: 338   SITWRTSTRNISSEEKASWTRPEKQET 364
             +I       N   E++ +  R  K  T
Sbjct: 29562 TIDGGAPVNNYIVEKREAAMRAFKTVT 29588



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 115/493 (23%), Positives = 182/493 (36%), Gaps = 71/493 (14%)

Query: 151   WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV 210
             W    R   L+  +  +     YL  R +   ++G  R + R LA   I  KD+ +  +V
Sbjct: 23177 WSECARVKSLQAVITNLTQGEEYL-FRVVAVNEKG--RSDPRSLAV-PIVAKDLVIEPDV 23232

Query: 211   PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270
              P   +       +  +GQ + +     G P+PT++WTKDG  ++Q         S D +
Sbjct: 23233 KPAFSSY------SVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQ-TTRINVTDSLDLT 23285

Query: 271   QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330
              L+IK+  K+D  +Y     N  G++ A+I +    KP       +      E +TL   
Sbjct: 23286 TLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITL--- 23342

Query: 331   ASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDA 390
              S +P P  T      N            +K++T      V S A V+  TLK  +    
Sbjct: 23343 -SWNP-PLYTGGCQITNYI---------VQKRDTTTTVWDVVS-ATVARTTLKVTKLKTG 23390

Query: 391   GEY--ICTASNTIGQD--SQSMYLEVQYAPKLQGPVA------------VYTWEGNQVNI 434
              EY     A N  GQ    +S  +  QY  K  GP              V  W     N 
Sbjct: 23391 TEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNG 23450

Query: 435   TCEVFAY-----PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 489
                V  Y        +I W +  + +   + +  K  N       E    +EN  G    
Sbjct: 23451 GSPVIGYHLERKERNSILWTKVNKTI--IHDTQFKAQNLEEGIEYEFRVYAENIVG---- 23504

Query: 490   TAVNRIGQESLEFILVQ-ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWR 548
               V +  + S  ++     D P +P    V+    T  +Q+ +P   GG  I  Y  E R
Sbjct: 23505 --VGKASKNSECYVARDPCDPPGTPEPIMVKRNEIT--LQWTKPVYDGGSMITGYIVEKR 23560

Query: 549   AVGEEVWHSKWYDAKEAS-MEGIVTIVGLKPETTYAVRLAALNGKG--------LGEISA 599
              + +     +W  A   + +E   T+ GL  +  Y  R+ A N  G         G I+A
Sbjct: 23561 DLPD----GRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITA 23616

Query: 600   ASEFKTQPVQGEP 612
               E +   +  +P
Sbjct: 23617 KDEVELPRISMDP 23629



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 98/448 (21%), Positives = 166/448 (37%), Gaps = 45/448 (10%)

Query: 23    DIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLT 82
             DI+ ++ E  VG S  F C V+       I+ +  +G  +  + +   +   D     L 
Sbjct: 11123 DIILTESEF-VGSSAIFECLVSPSTA---ITTWMKDGSNIRESPKHRFIA--DGKDRKLH 11176

Query: 83    IYNANIDDAGIYKCVV-TGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV 141
             I +  + DAG Y CV+  G     S A + V+       K         +G+   + C++
Sbjct: 11177 IIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCEL 11236

Query: 142   VSSLPPTIIWKHKGRDVILK--KDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 199
               +    ++W+  G+ V+ K  + V  ++     L I     TD GTY      +     
Sbjct: 11237 --NKERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTY-----TVTVENA 11289

Query: 200   NFKDIQVIVNVPPTIQ--ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
             N  +    V V   I+    + I +       +    CD      P + W K  ++I  E
Sbjct: 11290 NNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDI-AKDTPNIKWFKGYDEIPAE 11348

Query: 258   EDDEKYIFSDDSS-QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
              +D+  I  D +   L IK     D AEY    E K     A + L       +  +E+ 
Sbjct: 11349 PNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGK--RYPAKLTLGEREVELLKPIEDV 11406

Query: 317   TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHAR 376
             T  E +E  +   E S   IP   W+          K    RP           +++   
Sbjct: 11407 TIYE-KESASFDAEISEADIPG-QWKL---------KGELLRPSPT------CEIKAEGG 11449

Query: 377   VSSLTLKSIQYTDAGEYICTASNTIGQDSQSM-YLEVQYAPKLQGPVAVYTWEGNQVNIT 435
                LTL  ++   AGE +  A N I     ++  +E+ +A  L+    V   E  Q    
Sbjct: 11450 KRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKD---VTVPERRQARFE 11506

Query: 436   CEVFAYPSATISWFRDGQLLPSSNYSNI 463
             C +     A + W +   ++ SS+  +I
Sbjct: 11507 CVLTR--EANVIWSKGPDIIKSSDKFDI 11532



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 35/118 (29%), Positives = 58/118 (49%), Gaps = 10/118 (8%)

Query: 191   GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
             G I AR E++   I +      TI     +V+A    G+S  +  D  G P PT+ W K 
Sbjct: 22530 GAITARDEVDPPRISMDPKYKDTI-----VVHA----GESFKVDADIYGKPIPTIQWIKG 22580

Query: 251   GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
              +++      E    +D ++ L++K   + D   YI  A+N AGE+  T+++KV  +P
Sbjct: 22581 DQELSNTARLE-IKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRP 22637



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 94/497 (18%), Positives = 182/497 (36%), Gaps = 53/497 (10%)

Query: 224   TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEA 283
             T  +G +V L    +G P+P++SW KDG  + +E +  ++  +++   L+IK   K    
Sbjct: 27574 TVRIGHNVHLELPYKGKPKPSISWLKDGLPL-KESEFVRFSKTENKITLSIKNAKKEHGG 27632

Query: 284   EYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRT 343
             +Y  I +N        I +     P     + +  +  +       E   D +  ++W  
Sbjct: 27633 KYTVILDNAVCRIAVPITVITLGPPS----KPKGPIRFD-------EIKADSV-ILSWDV 27680

Query: 344   STRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLT---LKSIQYTDAGEYICTASNT 400
                N   E         +    +  MV  S AR +      +K  +Y    ++   A N 
Sbjct: 27681 PEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEY----QFRVRAENR 27736

Query: 401   IG--QDSQSMYLEVQYAPKLQGP---VAVYTWEGNQVNITCEVFAYPSAT-ISWF----- 449
              G  Q   S  +  ++  ++ GP     +Y    + +++T +   Y   + ++ F     
Sbjct: 27737 YGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKK 27796

Query: 450   -RDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD 508
              R+  L    N S I      +   +E        +   +    +          +   D
Sbjct: 27797 ERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVD 27856

Query: 509   TPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME 568
              P +P  D ++    T  ++++ P   GG  I+ Y  E R   E      + D  E    
Sbjct: 27857 PPGTP--DYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQ-- 27912

Query: 569   GIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKL--------EGQ 620
                T+ GL P   Y  R+ A N   +G IS  S+     +  + + P +        +G 
Sbjct: 27913 --YTVTGLSPGDRYEFRIIARN--AVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGL 27968

Query: 621   MGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPS--GSDHVMLKSLDWNA 678
             + + G S+++  + Q   G P+         +  E +  + +    GS  + ++    + 
Sbjct: 27969 IIKSGESLRIKALVQ---GRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDH 28025

Query: 679   EYEVYVVAENQQGKSKA 695
                  V A+N  G +KA
Sbjct: 28026 RGVYTVEAKNASGSAKA 28042



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 42/193 (21%), Positives = 74/193 (38%), Gaps = 4/193 (2%)

Query: 120   FKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKK-DVRFIVLSNNYLQIRG 178
             FK        R   +A +VC V     P + W  +G+++I      R       Y Q+  
Sbjct: 30930 FKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLII 30989

Query: 179   IKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVN---ATANLGQSVTLVC 235
                TD+     + R   +G        + V VP  I   + +       A  G+ V++  
Sbjct: 30990 ASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKI 31049

Query: 236   DAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295
                G P+P ++W K  + I+     +  +    +S +    V++ D   Y+  A+N+ G 
Sbjct: 31050 PFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGI 31109

Query: 296   QDATIHLKVFAKP 308
                T+ L V   P
Sbjct: 31110 DQKTVELDVADVP 31122



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 35/116 (30%), Positives = 52/116 (44%), Gaps = 10/116 (8%)

Query: 193   ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGE 252
             I  R ++    I+V V    T+     I+ A    G++  L  D  G P PTM W+KDG+
Sbjct: 21450 ITCRDDVEAPKIKVDVKFKDTV-----ILKA----GEAFRLEADVSGRPPPTMEWSKDGK 21500

Query: 253   QIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
             ++E     E  I +D S+ L  K   + D   Y   A N  G      ++KV  +P
Sbjct: 21501 ELEGTAKLEIKI-ADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRP 21555



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 94/418 (22%), Positives = 173/418 (41%), Gaps = 57/418 (13%)

Query: 209   NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY----- 263
             ++PP+I  ++ +       G +V +V   +G P PT++W K   +    ++   Y     
Sbjct: 16115 DMPPSIDLKEFM---EVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVN 16171

Query: 264   -IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVENQTAME 320
              +  DD+  L I +  ++D   Y   A N  G     + L V  +  P +  ++ ++   
Sbjct: 16172 KLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSA 16231

Query: 321   LEEQVTLTC----EASGDPIPS--ITWRTSTR----NISSEEK-ASWTRPEKQETLDGHM 369
               +Q+TL+     +  G  I +  I  R + R    ++SSE K  ++T P+    L+GH 
Sbjct: 16232 --DQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPK---LLEGHE 16286

Query: 370   VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEG 429
              V    R+ +     I     GE + +   T    +++++  V  AP  +  V+  T   
Sbjct: 16287 YV---FRIMAQNKYGI-----GEPLDSEPET----ARNLF-SVPGAPD-KPTVSSVTRNS 16332

Query: 430   NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKI----YNTPSASYLEVTPDSENDFG 485
               VN     +   S    ++ + +   S  +  +        T   SY +VT   E    
Sbjct: 16333 MTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTLGVSY-KVTGLIEGSDY 16391

Query: 486   NYNCTAVNR--IGQESLEFILVQAD---TPSSPSIDQVEPYS-STAQVQFDEPEATGGVP 539
              +   A+N   +G  SL      A     P  P   +V  ++ S+A +++  P   GG  
Sbjct: 16392 QFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDGGSK 16451

Query: 540   ILKYKAEWRAVGEEVWHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGE 596
             +  Y  E++  G+E    +W   K+  + G  + + GLK    Y  R+ A+N  G+GE
Sbjct: 16452 VTGYIVEYKEEGKE----EWEKGKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAGIGE 16505



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 75/353 (21%), Positives = 137/353 (38%), Gaps = 42/353 (11%)

Query: 261   EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME 320
             E+ +  D    L ++ V+    +E   I+EN   +           KP I    +   + 
Sbjct: 14347 EEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPD-------CKPTIDLETHDIIVI 14399

Query: 321   LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSL 380
               E++++       P+P+++W    + + + ++ +     K + +  H+ V    R    
Sbjct: 14400 EGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTM----KNDHISAHLEVPKSVR---- 14451

Query: 381   TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFA 440
                     DAG Y  T  N +G  + S+ ++V   P     +       +   +T E   
Sbjct: 14452 -------ADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPE 14504

Query: 441   YPSAT--ISWFRDGQLLPSSNYSNIKI-YNTPSASYLEVTPDSENDFGNYNCTAVNRI-G 496
             +   T  + +  + +      Y  +    N  S +  ++ P+ E  F      AVN++ G
Sbjct: 14505 FDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFF---RVKAVNKVGG 14561

Query: 497   QESLEF----ILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKAEWRA 549
              E +E     I      P  P +D VE ++ TA+   + +  P   GG  I+ Y  E  A
Sbjct: 14562 GEYIELKNPVIAQDPKQPPDPPVD-VEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIA 14620

Query: 550   VGEEVWHSKWYDAKEASMEGIV-TIVGLKPETTYAVRLAALNGKGLGEISAAS 601
              GEE    +W    E  +  +  T  GL+    Y  R+ A N  G+ E S A+
Sbjct: 14621 KGEE----RWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRAT 14669



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 99/478 (20%), Positives = 170/478 (35%), Gaps = 93/478 (19%)

Query: 259   DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE---- 314
             D   +I +    +  ++ + + +E  +  +A N AG         V  K +    E    
Sbjct: 21009 DQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLR 21068

Query: 315   ----NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMV 370
                      +  + + +     G P P++TW+   + +   ++ ++        L+ +  
Sbjct: 21069 GIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINEC 21128

Query: 371   VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN 430
             VRS               D+G Y  TA N +G+    + ++V   P   GP         
Sbjct: 21129 VRS---------------DSGPYPLTARNIVGEVGDVITIQVHDIP---GPPT------- 21163

Query: 431   QVNITCEVFAYPSATISW---FRDGQLLPSSNYSNIKIYNTPSASYLE------------ 475
                I  +  +    T SW     DG  +P SNY  +++  T S +++E            
Sbjct: 21164 -GPIKFDEVSSDFVTFSWDPPENDGG-VPISNYV-VEMRQTDSTTWVELATTVIRTTYKA 21220

Query: 476   --VTPDSENDFGNYNCTAVNRIG-QESLEFILVQAD-------TPSSPSIDQVEPYSSTA 525
               +T   E  F      A NR G    +    + A+        P +P +  V   S T 
Sbjct: 21221 TRLTTGLEYQF---RVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMT- 21276

Query: 526   QVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVR 585
              + + EP + GG PIL Y  E +     +W +    +K      I    GL     Y  R
Sbjct: 21277 -ISWHEPLSDGGSPILGYHVERKERNGILWQTV---SKALVPGNIFKSSGLTDGIAYEFR 21332

Query: 586   LAALNGKGLGEISAASEFKTQPVQGEPSAPKLE-GQMGEDGNSIKVNLIK---------- 634
             + A N  G          K++P   +PS P L    +   G  + +N+ +          
Sbjct: 21333 VIAENMAG----------KSKP--SKPSEPMLALDPIDPPGKPVPLNITRHTVTLKWAKP 21380

Query: 635   QDDGGSPIRHYLVRYRAL-SSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 691
             +  GG  I  Y+V  R L +  W          +   +  L  +A YE  V+A+N  G
Sbjct: 21381 EYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAG 21438



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 84/446 (18%), Positives = 160/446 (35%), Gaps = 76/446 (17%)

Query: 102  DGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILK 161
            +G+ +  T + K  QK      P P    EGE A   C V     P + W   G+  +++
Sbjct: 1825 EGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQ--LIR 1882

Query: 162  KDVRFIVLSN--NYLQIRGIKKTDEGTYRC-----EGRILARGEI------NFKDI---- 204
            K  RF V  +  +YL I   K  D G  +      EG I  + ++      +F+ +    
Sbjct: 1883 KSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRA 1942

Query: 205  -----QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE---Q 256
                 +  V+ P  +Q     V+   +  ++  +V              ++ E++    +
Sbjct: 1943 PEPRPEFHVHEPGKLQFEVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFK 2002

Query: 257  EEDDEKYIFSDDSSQLTIKKVDKNDE-------------AEYICIAENKAGEQDATIHLK 303
               +E Y  +  + +L  +K D++ E              + +   E KA  ++  I + 
Sbjct: 2003 RRTEEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIP 2062

Query: 304  VFAKPKITYVENQTAMELEEQVT-----------LTCEASGDPIPSITWRTSTRNISSEE 352
             F   KI    +  A ++ E++                  G P P   W  +   I   +
Sbjct: 2063 TFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSD 2122

Query: 353  KASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 412
            +  W  PE                V  L ++ +   D+   +  A N  G+ S   +L V
Sbjct: 2123 RIYWYWPED--------------NVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLV 2168

Query: 413  Q------YAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIY 466
            Q      +  +LQ  VA    +       CE  + P   + W++DG  +   +    +++
Sbjct: 2169 QAKQLITFTQELQDVVA--KEKDTMATFECET-SEPFVKVKWYKDGMEVHEGD--KYRMH 2223

Query: 467  NTPSASYLEVTPDSENDFGNYNCTAV 492
            +     +L +     +D  +Y+C  V
Sbjct: 2224 SDRKVHFLSILTIDTSDAEDYSCVLV 2249



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 49/190 (25%), Positives = 77/190 (40%), Gaps = 28/190 (14%)

Query: 228   GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD--SSQLTIKKVDKNDEAEY 285
             G+ +++       P PT+SW KDG++++     ++    +D  S+ L + K  + D   Y
Sbjct: 14401 GEKLSIPVPFRAVPVPTVSWHKDGKEVKA---SDRLTMKNDHISAHLEVPKSVRADAGIY 14457

Query: 286   ICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEA----SGDPIPSITW 341
                 ENK G   A+I++KV   P     + + +   +    LT E      G PI     
Sbjct: 14458 TITLENKLGSATASINVKVIGLPG-PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVL 14516

Query: 342   -------RTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 394
                    RT    +S E K SWT   K    +G    R         +K++     GEYI
Sbjct: 14517 ERREAGRRTYIPVMSGENKLSWT--VKDLIPNGEYFFR---------VKAVNKVGGGEYI 14565

Query: 395   CTASNTIGQD 404
                +  I QD
Sbjct: 14566 ELKNPVIAQD 14575



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 37/135 (27%), Positives = 56/135 (41%), Gaps = 18/135 (13%)

Query: 176   IRGIKKTDEGTYRCE--GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTL 233
             I G  K D     CE  G I A   +   ++ +  N   T     ++V A    G S+ L
Sbjct: 28331 INGAGKGDS----CEVTGTIKAVDRLTAPELDIDANFKQT-----HVVRA----GASIRL 28377

Query: 234   VCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKA 293
                 +G P PT  W+K    +    D      +D  S LT++  ++ND  +Y    EN +
Sbjct: 28378 FIAYQGRPTPTAVWSKPDSNLSLRADIHT---TDSFSTLTVENCNRNDAGKYTLTVENNS 28434

Query: 294   GEQDATIHLKVFAKP 308
             G +  T  +KV   P
Sbjct: 28435 GSKSITFTVKVLDTP 28449



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 65/289 (22%), Positives = 109/289 (37%), Gaps = 54/289 (18%)

Query: 326   TLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSI 385
             T+T    G P+P++ W     ++ +            +T D           +SLT+++ 
Sbjct: 26205 TMTVPFRGRPVPNVLWSKPDTDLRTRAYV--------DTTDSR---------TSLTIENA 26247

Query: 386   QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT 445
                D+G+Y  T  N +   S ++ ++V   P            G   NIT +     SA 
Sbjct: 26248 NRNDSGKYTLTIQNVLSAASLTLVVKVLDTP------------GPPTNITVQDVTKESAV 26295

Query: 446   ISW---FRDGQLLPSSNY----------SNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 492
             +SW     DG   P  NY          + + + N  +    +VT   E     +  +  
Sbjct: 26296 LSWDVPENDGG-APVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGE 26354

Query: 493   NRIG----QESLEFILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGVPILKYKAEW 547
             N  G     E+ E + +  + PS P    V   S  +  + + +PE  GG  I+ Y  E 
Sbjct: 26355 NEFGVGIPAETKEGVKI-TEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEA 26413

Query: 548   RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 596
                G++ W  K   AK         + GL+  + Y  R+ A N  GL +
Sbjct: 26414 LEKGQKNW-VKCAVAKSTHH----VVSGLRENSEYFFRVFAENQAGLSD 26457



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 58/281 (20%), Positives = 110/281 (39%), Gaps = 29/281 (10%)

Query: 323   EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTL 382
             E V +     G P P++TWR   +N+ S+ + S    +                 S LT+
Sbjct: 27287 EDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSS---------------SLLTI 27331

Query: 383   KSIQYTDAGEYICTASNTIGQ-DSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCE--VF 439
               +   D G+YI T  N +G+  S ++ ++V   P     + V       V +  +  + 
Sbjct: 27332 PQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLI 27391

Query: 440   AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG--- 496
                S  I++  + +      +S +  +   S S+  +    +  F  +   A N IG   
Sbjct: 27392 DGGSPIINYVIEKRDATKRTWSVVS-HKCSSTSFKLIDLSEKTPF-FFRVLAENEIGIGE 27449

Query: 497   -QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW 555
               E+ E +           +   +   ++  + + +P+  GG  I +Y  E +  GE+ W
Sbjct: 27450 PCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTW 27509

Query: 556   HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 596
              S    +K   +E    +  LK ++    R+ A N KGL +
Sbjct: 27510 -SHAGISKTCEIE----VSQLKEQSVLEFRVFAKNEKGLSD 27545



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 58/247 (23%), Positives = 99/247 (40%), Gaps = 32/247 (12%)

Query: 486   NYNCTAVNRIGQ----ESLEFILVQADT--PSSPS-IDQVEPYSSTAQVQFDEPEATGGV 538
             ++   AVN+ G+    E  + +L +     PS P  ++ +    +TA +++  PE  GG 
Sbjct: 14054 SFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKDGGS 14113

Query: 539   PILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 598
             PI  Y  E R V  + W +     K+       T+  L   + Y  R+AA N  G  + +
Sbjct: 14114 PITNYIVEKRDVRRKGWQTVDTTVKDTK----CTVTPLTEGSLYVFRVAAENAIGQSDYT 14169

Query: 599   AASEF----KTQPVQGEPSAPKLEGQMGEDGNSIKVNL---IKQDDGGSPIRHYLV-RYR 650
                +      T    G P A  +      D     V+L     ++DGG PI+ Y++ +  
Sbjct: 14170 EIEDSVLAKDTFTTPGPPYALAV-----VDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKE 14224

Query: 651   ALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIP 710
              L + W    +      +  +  +    E +  V AEN+ G            ++PT I 
Sbjct: 14225 RLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGH--------PSEPTEIL 14276

Query: 711   ANGSPTS 717
             +   PTS
Sbjct: 14277 SIEDPTS 14283



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 97/528 (18%), Positives = 196/528 (37%), Gaps = 46/528 (8%)

Query: 210   VPPTIQARQNIVNA-TANLGQSVTLVCDAEGFPEPTMSWTKD-GEQIEQEEDDEKYIFSD 267
             +PP I+   ++    T     ++ L    +G P P + W +D GE +++   +     + 
Sbjct: 21856 LPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIES----TS 21911

Query: 268   DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327
               + L +  V++ D  +YI   EN +G + A ++++V   P          ++++E    
Sbjct: 21912 SYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTP-----GPPQDLKVKEVTKT 21966

Query: 328   TCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQY 387
             +   + DP P +   +  +N   E++ S        T   +  V ++   +S  +  +Q 
Sbjct: 21967 SVTLTWDP-PLLDGGSKIKNYIVEKRES--------TRKAYSTVATNCHKTSWKVDQLQE 22017

Query: 388   TDAGEYICTASNTIG---QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYP-- 442
               +  +   A N  G       +  ++    P   G + +     N V+++ E   +   
Sbjct: 22018 GCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEHDGG 22077

Query: 443   SATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG---QES 499
             S  + +  + Q   S  ++         A+   +    E  F     +A N  G      
Sbjct: 22078 SRILGYIVEMQTKGSDKWATCATVKVTEATITGLIQGEEYSF---RVSAQNEKGISDPRQ 22134

Query: 500   LEFILVQADTPSSPSIDQV-EPYSSTA--QVQFDEPEATGGVPILKYKAEWRAVGEEVWH 556
             L   ++  D    P+   +   ++  A   ++ D P      P +     W      +  
Sbjct: 22135 LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAV----TWHKDNVPLKQ 22190

Query: 557   SKWYDAKEASMEGIVTIVGLKPETT--YAVRLAALNGKGLGEISAASEFKTQPVQGEPSA 614
             +   +A+      ++TI     E    Y V+L    G+ +  ++     K     G P+ 
Sbjct: 22191 TTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDK----PGPPTG 22246

Query: 615   PKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSL 674
             P    ++  D  ++     K  DGGS I +Y+V  R  S+     +        +    L
Sbjct: 22247 PVKMDEVTADSITLSWGPPKY-DGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRL 22305

Query: 675   DWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPA-NGSPTSGLST 721
                 EY+  + AEN+ GKS   +     +  P  +P   G+P   LS+
Sbjct: 22306 KTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSS 22353



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 70/335 (20%), Positives = 110/335 (32%), Gaps = 47/335 (14%)

Query: 415   APKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSN------------ 462
             APK+    ++    G+++ +   +   P  TI+W +D  ++                   
Sbjct: 14680 APKVILRTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGE 14739

Query: 463   --------------IKIYNTPSA-SYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 507
                           + I N+    S L V      D G Y     N  G       +   
Sbjct: 14740 VQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVL 14799

Query: 508   DTPSSPSIDQVEPYSSTAQV-QFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEAS 566
             DTP  P     E    T+ + +++ P   GG  I+ Y  E +   +    S+W       
Sbjct: 14800 DTPGPPINFVFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKP--DSEWIVVTSTL 14857

Query: 567   MEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGN 626
                  ++  L     Y  R+ A N  G G    +     +   G P AP          N
Sbjct: 14858 RHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSN 14917

Query: 627   SIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVA 686
             S+ V   +  D GSPI  Y +  R ++S     +           KSL       +  + 
Sbjct: 14918 SMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVN----------KSL-------LNALK 14960

Query: 687   ENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLST 721
              N  G  +   +VFR  A+  A P   SP S   T
Sbjct: 14961 ANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKT 14995



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 23/81 (28%), Positives = 42/81 (51%), Gaps = 3/81 (3%)

Query: 228   GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
             G S  +    +G P P ++W+++  +   +   EK +   + +QL+I   D+ND  +YI 
Sbjct: 24039 GGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGV---NYTQLSIDNCDRNDAGKYIL 24095

Query: 288   IAENKAGEQDATIHLKVFAKP 308
               EN +G + A + +KV   P
Sbjct: 24096 KLENSSGSKSAFVTVKVLDTP 24116



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 37/150 (24%), Positives = 63/150 (42%), Gaps = 24/150 (16%)

Query: 462   NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPY 521
             N ++ +    + ++    +EN+ G         +G  S    ++  + P+SP    ++ +
Sbjct: 14242 NFRVTDVIEGTEVQFQVRAENEAG---------VGHPSEPTEILSIEDPTSPPSPPLDLH 14292

Query: 522   SSTA-----QVQFDEPEATGGVPILKYKAEWRAVGEEVW----HSKWYDAKEASMEGIVT 572
              + A      + +  PE  GG PI+ Y  E   VG E W         D K    EG+V 
Sbjct: 14293 VTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVV- 14351

Query: 573   IVGLKPETTYAVRLAALNGKGLGEISAASE 602
                  P+  Y +R+ A+N  G+ E S  SE
Sbjct: 14352 -----PDKEYVLRVRAVNAIGVSEPSEISE 14376



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 59/273 (21%), Positives = 101/273 (36%), Gaps = 22/273 (8%)

Query: 429   GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
             G        V + P+A + W+ +G  L  S  S I   NT     LE+     +D G Y 
Sbjct: 32388 GQNTRFILNVQSKPTAEVKWYHNGVELQES--SKIHYTNTSGVLTLEILDCHTDDSGTYR 32445

Query: 489   CTAVNRIGQES----LEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYK 544
                 N  G+ S    L+       T +S   D+  P S   ++   E  A          
Sbjct: 32446 AVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTEAYAV--------- 32496

Query: 545   AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 604
             + ++   E    S   + K    E   ++   +   +  ++ AAL  K L E S   + K
Sbjct: 32497 SSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIK 32556

Query: 605   TQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRH--YLVRYRALSSEWKPEIRL 662
             T       + P+       +G S + +    D  G P+    +L + + LS+  + ++  
Sbjct: 32557 TTLAARILTKPR--SMTVYEGESARFSC---DTDGEPVPTVTWLRKGQVLSTSARHQVTT 32611

Query: 663   PSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 695
                     + S+  + E    VV EN +GK +A
Sbjct: 32612 TKYKSTFEISSVQASDEGNYSVVVENSEGKQEA 32644



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 88/453 (19%), Positives = 175/453 (38%), Gaps = 67/453 (14%)

Query: 14   LGTAVSLQVD---IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRIS 70
            LG +  L V+   I+    +++  E+     +V+       + WF  + E    ++ R+ 
Sbjct: 2784 LGASARLHVETVKIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLV 2843

Query: 71   VVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR 130
               ++     L + N +  DAG Y  VV G+   +++  V      K M KN   P    
Sbjct: 2844 ---SERKVHKLMLQNISPSDAGEYTAVV-GQLECKAKLFVETLHITKTM-KNIEVP---- 2894

Query: 131  EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN-NYLQIRGIKKTDEGTYRC 189
            E + A   C+V     P++ W   G ++ + +  + +V    + L I      D   Y  
Sbjct: 2895 ETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTF 2953

Query: 190  EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK 249
               +    +++      +   P  I +    +NA      +  +  + EG    +  W K
Sbjct: 2954 ---VCGNDQVS----ATLTVTPIMITSMLKDINAEEKDTITFEVTVNYEGI---SYKWLK 3003

Query: 250  DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309
            +G +I+  +  +        S L I+ V   D A+Y  +A        AT++++      
Sbjct: 3004 NGVEIKSTDKCQMRTKKLTHS-LNIRNVHFGDAADYTFVAGKATST--ATLYVEARHIEF 3060

Query: 310  ITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHM 369
              ++++   +E +++    CE S    P IT               W + +++  +   +
Sbjct: 3061 RKHIKDIKVLE-KKRAMFECEVSE---PDIT-------------VQWMKDDQELQITDRI 3103

Query: 370  VVRSHARVSSLTLKSIQYTDAGEYICTASNTI--------GQD--SQSMYLEVQYAPKLQ 419
             ++    V  L + S + +DAG+Y   A   +        G+D   +S+  EVQ   K +
Sbjct: 3104 KIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQR 3163

Query: 420  GPVAVYTWEGNQVNITCEVFAYPSATISWFRDG 452
               AV  +E N+ ++             W++DG
Sbjct: 3164 ---AVVEFEVNEDDVDAH----------WYKDG 3183



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 33/119 (27%), Positives = 54/119 (45%), Gaps = 10/119 (8%)

Query: 197   GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
             GEI   DIQ    V   I A+  +V      G  + +    +G P P  SW  DG+  + 
Sbjct: 15797 GEIPATDIQEEPEVFIDIGAQDCLV---CKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKA 15853

Query: 257   EED-------DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
              +D       D +   +++SS + I +  ++   +Y   A+NKAG++ A   +KV   P
Sbjct: 15854 MKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVP 15912



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 96/427 (22%), Positives = 157/427 (36%), Gaps = 107/427 (25%)

Query: 225   ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
             A  G ++ +     G P+PT++W K G+QI ++     +  +  S+ L I +  ++D   
Sbjct: 21077 AKAGDNIKVEIPVLGRPKPTVTW-KKGDQILKQTQRVNFETTATSTILNINECVRSDSGP 21135

Query: 285   YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTS 344
             Y   A N  GE    I ++V   P                        G P   I +   
Sbjct: 21136 YPLTARNIVGEVGDVITIQVHDIP------------------------GPPTGPIKF--- 21168

Query: 345   TRNISSE-EKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQ 403
                +SS+    SW  PE     DG + + ++       +  ++ TD+  ++  A+  I  
Sbjct: 21169 -DEVSSDFVTFSWDPPEN----DGGVPISNY-------VVEMRQTDSTTWVELATTVIRT 21216

Query: 404   DSQSMY----LEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYP----------------- 442
               ++      LE Q+  K Q    V    G  +   C V  YP                 
Sbjct: 21217 TYKATRLTTGLEYQFRVKAQNRYGV----GPGITSACIVANYPFKVPGPPGTPQVTAVTK 21272

Query: 443   -SATISW---FRDGQLLPSSNY------SNIKIYNTPSASYL--EVTPDSENDFG---NY 487
              S TISW     DG   P   Y       N  ++ T S + +   +   S    G    +
Sbjct: 21273 DSMTISWHEPLSDGG-SPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEF 21331

Query: 488   NCTAVNRIGQESLEFILVQADTPSSP--SIDQVEPYSS---------TAQVQFDEPEATG 536
                A N  G+        +   PS P  ++D ++P            T  +++ +PE TG
Sbjct: 21332 RVIAENMAGKS-------KPSKPSEPMLALDPIDPPGKPVPLNITRHTVTLKWAKPEYTG 21384

Query: 537   GVPILKYKAEWRAVGEEVWHSKWYDAKEAS-MEGIVTIVGLKPETTYAVRLAALNGKGLG 595
             G  I  Y  E R    ++ + +W  A  ++ +E   T+ GL  +  Y  R+ A N    G
Sbjct: 21385 GFKITSYIVEKR----DLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKN--AAG 21438

Query: 596   EISAASE 602
              IS  SE
Sbjct: 21439 AISPPSE 21445



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 94/431 (21%), Positives = 161/431 (37%), Gaps = 57/431 (13%)

Query: 210   VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269
             +PP  +   N     A  G+ + +     G P P ++W KD   ++Q         ++++
Sbjct: 22146 IPPAFKLLFNTFTVLA--GEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAES-TENN 22202

Query: 270   SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTC 329
             S LTIK   + D   Y+    N AGE   T+++ V  KP          ++++E    + 
Sbjct: 22203 SLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPG----PPTGPVKMDEVTADSI 22258

Query: 330   EASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTD 389
               S  P P     +S  N   E++ +        T    +V    A V+  T+K+ +   
Sbjct: 22259 TLSWGP-PKYDGGSSINNYIVEKRDT-------STTTWQIV---SATVARTTIKACRLKT 22307

Query: 390   AGEY--ICTASNTIGQDS--QSMYLEVQYAPKLQGP-----VAVYTWEGNQVNITCEVFA 440
               EY     A N  G+ +   S     QY  K+ GP     V + + +  +V     +  
Sbjct: 22308 GCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEPISD 22367

Query: 441   YPSATISWFRDGQLLPSSNYSNIKIYNTP------SASYLEVTPDSENDFGNYNCTAVNR 494
               S  I +  + +   S  +  +K+  TP        + LE   + E      N   + +
Sbjct: 22368 GGSRVIGYHLERKERNSILW--VKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGK 22425

Query: 495   IGQESLEFILVQ-ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEE 553
               + S  ++     D P  P    V   S T  +Q+ +P   GG  I  Y  E + + E 
Sbjct: 22426 PSKVSECYVARDPCDPPGRPEAIIVTRNSVT--LQWKKPTYDGGSKITGYIVEKKELPEG 22483

Query: 554   VWHSKWYDAKEASMEGIV----TIVGLKPETTYAVRLAALNGKGL--------GEISAAS 601
              W        +AS   I+     + GL  +  Y  R+ A N  G+        G I+A  
Sbjct: 22484 RW-------MKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARD 22536

Query: 602   EFKTQPVQGEP 612
             E     +  +P
Sbjct: 22537 EVDPPRISMDP 22547



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 88/411 (21%), Positives = 152/411 (36%), Gaps = 78/411 (18%)

Query: 288   IAENKAGEQD-ATIHLKVFAKPKITYVE--------NQTAMELEEQVTLTCEASGDPIPS 338
             +A N AGE D A +   V  K ++   E         +  +++ + + L+    G P P 
Sbjct: 17190 LAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPK 17249

Query: 339   ITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 398
             +TW+   R+  ++ +   T                    S L +++  + D G Y  T  
Sbjct: 17250 VTWKKEDRDAPTKARIDVTPVG-----------------SKLEIRNAAHEDGGIYSLTVE 17292

Query: 399   NTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDGQLL 455
             N  G  + S+ + V   P            G   ++        S  ++W     DG  +
Sbjct: 17293 NPAGSKTVSVKVLVLDKP------------GPPRDLEVSEIRKDSCYLTWKEPLDDGGSV 17340

Query: 456   PSSNYSNIKIYNTPSASYLEVTPDSENDF------GN---YNCTAVNRIGQ----ESLEF 502
              ++     +   +   S L  T   ++ F      GN   +   A N+ G+    E+ + 
Sbjct: 17341 ITNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKP 17400

Query: 503   I--LVQADTPSSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKW 559
             I  L     P  P  +  V+   +   + +++P+  GG PI  Y  E++  G + W    
Sbjct: 17401 IKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKF- 17459

Query: 560   YDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLG----EISAASEFKTQPVQGEPSAP 615
                   ++E +VT  GL+   TY  R+ A N  GLG     I    + K  P   E    
Sbjct: 17460 --KTVTNLECVVT--GLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVK 17515

Query: 616   KLEGQMGEDGNSIK---------VNLIKQDDGGSPIR---HYLVRYRALSS 654
              +EG + + G +++         V   K    GS I+   HY V     SS
Sbjct: 17516 LIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSS 17566



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 28/101 (27%), Positives = 48/101 (47%), Gaps = 3/101 (2%)

Query: 208   VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267
             + + P+++   N  +  A  G+ + +     G P P +SW KDGE ++Q         + 
Sbjct: 24308 LTIQPSLKLPFNTYSIQA--GEDLKIEIPVIGRPRPNISWVKDGEPLKQ-TTRVNVEETA 24364

Query: 268   DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
              S+ L IK+ +K+D  +Y   A N AG     + + V  KP
Sbjct: 24365 TSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKP 24405



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 41/143 (28%), Positives = 65/143 (45%), Gaps = 10/143 (6%)

Query: 474   LEVTPDSENDFGNYNCTAVNRIGQ----ESLEFILVQAD--TPSSPSIDQV-EPYSSTAQ 526
             L+VT   E     +  TAVN  G     E+  FI  +    TP  PS  +V +    +  
Sbjct: 29300 LKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSIS 29359

Query: 527   VQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRL 586
             + + +P   GG  I+ Y  E +    + W+    +A   + E   T+  LK    Y+ R+
Sbjct: 29360 LAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTE--FTVPDLKMGQKYSFRV 29417

Query: 587   AALNGKGLGEISAASEFKTQPVQ 609
             AA+N KG+ E S  S  + +PV+
Sbjct: 29418 AAVNVKGMSEYS-ESIAEIEPVE 29439



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 45/177 (25%), Positives = 64/177 (36%), Gaps = 24/177 (13%)

Query: 421  PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 480
            P  V   EG      C V  YP   ++W+ +GQL+  S    ++        YL++    
Sbjct: 1847 PEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY---DGIHYLDIVDCK 1903

Query: 481  ENDFGNYNCTAVNRIG------------QESLEFILVQADTPSSPSIDQVEPYSSTAQVQ 528
              D G    TA N  G            +E    +L +A  P  P     EP     +VQ
Sbjct: 1904 SYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRAPEP-RPEFHVHEPGKLQFEVQ 1962

Query: 529  -FDEP-EATGGVPILKYKAEWRAVGEEV------WHSKWYDAKEASMEGIVTIVGLK 577
              D P + T    ++K K   R   E+V        SK+    E      +T V LK
Sbjct: 1963 KVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAITAVELK 2019



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 80/377 (21%), Positives = 141/377 (37%), Gaps = 71/377 (18%)

Query: 253   QIEQEEDDEKYIFSDDS----SQLTIKKVDKNDEAEYICIAENKAG-EQDATIHLKVFAK 307
             +I   E+DE  I +  +    +  TI  + +N E +    A N  G  + A +     A+
Sbjct: 21793 EIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAE 21852

Query: 308   PKITYVENQTAMELEEQVTLTC--------EASGDPIPSITWRTSTRNISSEEKASWTRP 359
              ++   E +   +L + VT+             G P P + W     +  S +KAS    
Sbjct: 21853 DRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARD--HGESLDKAS---- 21906

Query: 360   EKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ 419
                        + S +  + L + ++   D+G+YI T  N+ G  S  + + V   P   
Sbjct: 21907 -----------IESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTP--- 21952

Query: 420   GPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIY-----NTPSASYL 474
                      G   ++  +     S T++W  D  LL     S IK Y      +   +Y 
Sbjct: 21953 ---------GPPQDLKVKEVTKTSVTLTW--DPPLLDGG--SKIKNYIVEKRESTRKAYS 21999

Query: 475   EVTPDSEN-----DFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQ----------VE 519
              V  +        D     C+   R+  E+   I + A+T  S    +          ++
Sbjct: 22000 TVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMD 22059

Query: 520   PYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPE 579
                ++  + +++PE  GG  IL Y  E +  G +    KW       +    TI GL   
Sbjct: 22060 VTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSD----KWATCATVKVTE-ATITGLIQG 22114

Query: 580   TTYAVRLAALNGKGLGE 596
               Y+ R++A N KG+ +
Sbjct: 22115 EEYSFRVSAQNEKGISD 22131



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 26/101 (25%), Positives = 46/101 (45%), Gaps = 7/101 (6%)

Query: 211   PPTIQARQNIVNATANL-GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD-- 267
             PP ++   ++      + G+++ +     G P PT  WTK+    E E D ++ +  +  
Sbjct: 15101 PPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKE----EGELDKDRVVIDNVG 15156

Query: 268   DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
               S+L IK   + D   Y+  A N  G + A   ++VF  P
Sbjct: 15157 TKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVP 15197



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 91/456 (19%), Positives = 168/456 (36%), Gaps = 70/456 (15%)

Query: 33    VGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAG 92
             +GE+    CQ+ G     DI W+    E +   + ++S   +D  + TLT+     +D G
Sbjct: 30546 LGEAAQLSCQIVGRPLP-DIKWYRFGKELIQSRKYKMS---SDGRTHTLTVMTEEQEDEG 30601

Query: 93    IYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV--VSSLPPTII 150
             +Y C+ T E G    ++  +           P  +++     + +   V  +    P + 
Sbjct: 30602 VYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMT 30661

Query: 151   WKHKGRDVILKKDVRFIVLSNNY--LQIRGI-KKTDEGTYRCEGRILARGEINFKDIQVI 207
             W H G+ ++   +   I  + +Y  L ++ + +KT  G Y+ +                +
Sbjct: 30662 WFH-GQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQ----------------L 30704

Query: 208   VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW---TKDG---------EQIE 255
              NV  T+ A  ++         +  +V +A       +SW     DG         E+ E
Sbjct: 30705 SNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCE 30764

Query: 256   QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYI--CIAENKAGEQD------ATIHLKVFAK 307
              +E  E  + S   S  T + V+  + A Y     A+N  G  D        I    F K
Sbjct: 30765 AKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEK 30824

Query: 308   PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDG 367
             P        TA+  +     +C  +  P P+       RN   E+     R +KQ     
Sbjct: 30825 PGAPGKPTITAVTKD-----SCVVAWKP-PASDGGAKIRNYYLEK-----REKKQNKWIS 30873

Query: 368   HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAV--Y 425
               V     R +  ++K++      E+     N +G +S+   +     PK   P+    +
Sbjct: 30874 --VTTEEIRETVFSVKNLIEGLEYEFRVKCEN-LGGESEWSEISEPITPKSDVPIQAPHF 30930

Query: 426   TWEGNQVNI--------TCEVFAYPSATISWFRDGQ 453
               E   +N+         C+V  +P   + W+R G+
Sbjct: 30931 KEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGK 30966



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 19/81 (23%), Positives = 42/81 (51%), Gaps = 3/81 (3%)

Query: 228   GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
             G S+ +    +G P P ++WTKD   ++   + E    ++  + L I + ++ D  +++ 
Sbjct: 20791 GLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIEN---TESFTLLIIPECNRYDTGKFVM 20847

Query: 288   IAENKAGEQDATIHLKVFAKP 308
               EN AG++   ++++V   P
Sbjct: 20848 TIENPAGKKSGFVNVRVLDTP 20868



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 29/150 (19%), Positives = 65/150 (43%), Gaps = 8/150 (5%)

Query: 166   FIVLSNNYLQIRGIKKTDEGTYRCEGR----ILARGEINFKDIQVIVNVPPT---IQARQ 218
             + ++S+N+  +  + + D   +R   +    ++++G  +   +       P    + AR 
Sbjct: 28993 YTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARL 29052

Query: 219   NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD 278
             +    T   G  + L     G PEP + WTK  ++++  E      ++   +   IK  D
Sbjct: 29053 HGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCE-KVSLQYTGKRATAVIKFCD 29111

Query: 279   KNDEAEYICIAENKAGEQDATIHLKVFAKP 308
             ++D  +Y    +N +G +  ++ +KV   P
Sbjct: 29112 RSDSGKYTLTVKNASGTKAVSVMVKVLDSP 29141



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 131/680 (19%), Positives = 232/680 (34%), Gaps = 101/680 (14%)

Query: 60    EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIF---- 115
             EK   +  R S+  N DSSS LTI     +D G Y   +    G    +TV+VK+     
Sbjct: 27309 EKNLGSDARYSIE-NTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPA 27367

Query: 116   --QKLMFKNAPTPQEFREGEDAVIVCD--VVSSLPPTIIWKHKGRDVILKKDVRFIVLSN 171
               QKL  K+              ++ D  ++    P I +  + RD   K+    +    
Sbjct: 27368 ACQKLQVKHVSRGT-------VTLLWDPPLIDGGSPIINYVIEKRDAT-KRTWSVVSHKC 27419

Query: 172   NYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSV 231
             +    + I  +++  +    R+LA  EI   +           +    I + +       
Sbjct: 27420 SSTSFKLIDLSEKTPFFF--RVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKT 27477

Query: 232   TLVCDAEGFPEPTMSWTK---DGEQIEQE---------EDDEKYIFSDDSSQLTIKKVDK 279
             +++          +SWTK   DG  +  E         E    +     + ++ + ++ +
Sbjct: 27478 SVI----------LSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKE 27527

Query: 280   NDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE--------NQTAMELEEQVTLTCEA 331
                 E+   A+N+ G  D      +  K  I   E         Q  + +   V L    
Sbjct: 27528 QSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPY 27587

Query: 332   SGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAG 391
              G P PSI+W      +   E   +++ E + T               L++K+ +    G
Sbjct: 27588 KGKPKPSISWLKDGLPLKESEFVRFSKTENKIT---------------LSIKNAKKEHGG 27632

Query: 392   EYICTASNTIGQDSQSMYLEVQYAP-KLQGPV---------AVYTWEGNQVN----ITCE 437
             +Y     N + + +  + +     P K +GP+          + +W+  + N    ITC 
Sbjct: 27633 KYTVILDNAVCRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITC- 27691

Query: 438   VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 497
              ++      S      +  S   +  K+ N    +  +    +EN +G         + Q
Sbjct: 27692 -YSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYG---------VSQ 27741

Query: 498   ESLEFILVQ------ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVG 551
               +  I+V          P  P I  V   S    + +D P   GG  +  +  E +   
Sbjct: 27742 PLVSSIIVAKHQFRIPGPPGKPVIYNVT--SDGMSLTWDAPVYDGGSEVTGFHVEKKERN 27799

Query: 552   EEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGE 611
               +W  K   +  +  E   T  GL     Y  R+ A N  GL   S  S+F       +
Sbjct: 27800 SILW-QKVNTSPISGREYRAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVD 27856

Query: 612   PSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVML 671
             P        +  +  ++K N   + DGGS I  Y +  R  +  W              +
Sbjct: 27857 PPGTPDYIDVTRETITLKWNPPLR-DGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTV 27915

Query: 672   KSLDWNAEYEVYVVAENQQG 691
               L     YE  ++A N  G
Sbjct: 27916 TGLSPGDRYEFRIIARNAVG 27935



 Score = 38.9 bits (89), Expect = 0.021
 Identities = 85/392 (21%), Positives = 159/392 (40%), Gaps = 65/392 (16%)

Query: 81    LTIYNANIDDAG--IYKCVVTGEDGSESEATVNVKIFQ---KLMFKNAPTPQEFREGEDA 135
             LT++   +D AG  +Y+ +      + + A + VK  +    +  K+   P+  +   + 
Sbjct: 11453 LTLHKVKLDQAGEVLYQAL-----NAITTAILTVKEIELDFAVPLKDVTVPERRQARFEC 11507

Query: 136   VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGR 192
             V+  +        +IW  KG D+I   D +F ++++   + L I   +  DEG Y  E  
Sbjct: 11508 VLTREA------NVIWS-KGPDIIKSSD-KFDIIADGKKHILVINDSQFDDEGVYTAE-- 11557

Query: 193   ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGE 252
                 G+   K    +      ++    + + T   G++ T VC+     +  + W K+  
Sbjct: 11558 --VEGK---KTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCELS-HEKMHVVWFKNDA 11611

Query: 253   QIEQEEDDEKYIFSDDSS--QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF-AKPK 309
             ++         + S +    +L +K+V  +D ++     + +  E  +T  LKV  A P 
Sbjct: 11612 KLHTSRT---VLISSEGKTHKLEMKEVTLDDISQI----KAQVKELSSTAQLKVLEADPY 11664

Query: 310   ITY-VENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGH 368
              T  + ++TA+E +E +TL CE S D +P + W      I    K S             
Sbjct: 11665 FTVKLHDKTAVEKDE-ITLKCEVSKD-VP-VKWFKDGEEIVPSPKYS------------- 11708

Query: 369   MVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ-YAPKLQGPV-AVYT 426
               +++      L +K     D GEY+C      G D     + V+    K++ P+  V  
Sbjct: 11709 --IKADGLRRILKIKKADLKDKGEYVCDC----GTDKTKANVTVEARLIKVEKPLYGVEV 11762

Query: 427   WEGNQVNITCEVFAYPSATISWFRDGQLLPSS 458
             + G   +   E+ + P     W   GQ L +S
Sbjct: 11763 FVGETAHFEIEL-SEPDVHGQWKLKGQPLTAS 11793



 Score = 38.1 bits (87), Expect = 0.035
 Identities = 47/204 (23%), Positives = 77/204 (37%), Gaps = 15/204 (7%)

Query: 117  KLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQI 176
            K +F   P   +  EG+ A     VV    P   W H G+ ++     + ++  +    +
Sbjct: 1456 KPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSL 1515

Query: 177  RGIKKT--DEGTYRCEGRILARGEINFKDIQVIVNVPPT-IQARQNIVNATANL----GQ 229
              +  T  D G    E  ++A+       I VI+ V     Q +   V    N+    G 
Sbjct: 1516 IIVPATPSDSG----EWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGS 1571

Query: 230  SVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI-FSDDSSQLTIKKVDKNDEAEYICI 288
             + +   A G P P + W K+ + I   +  +  I  +   + L I      D A Y   
Sbjct: 1572 RLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTAT 1631

Query: 289  AENKAGEQDATIHLKV---FAKPK 309
            A NKAG       + V   FA+P+
Sbjct: 1632 AINKAGRDTTRCKVNVEVEFAEPE 1655



 Score = 37.0 bits (84), Expect = 0.078
 Identities = 85/406 (20%), Positives = 155/406 (38%), Gaps = 100/406 (24%)

Query: 279   KNDEAEYICIAENKAGEQDAT-IHLKVFAKPKITYVENQTAMELEEQVTLTCEAS----- 332
             ++ + ++   A NK G  D + +  K + K  +   E +   +L + + L    +     
Sbjct: 19656 EDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYV 19715

Query: 333   ---GDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTD 389
                G P P ITW  S  N++  ++               + ++S    + L  +++   D
Sbjct: 19716 PVKGRPPPKITW--SKPNVNLRDRIG-------------LDIKSTDFDTFLRCENVNKYD 19760

Query: 390   AGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW- 448
             AG+YI T  N+ G+   ++ ++V   P            G  VN+T +  +  SA ++W 
Sbjct: 19761 AGKYILTLENSCGKKEYTIVVKVLDTP------------GPPVNVTVKEISKDSAYVTWE 19808

Query: 449   --FRDGQLLPSSNY---------------------SNIKIYNTPSASYLEVTPDSENDFG 485
                 DG   P  NY                     ++ ++ N            +EN++G
Sbjct: 19809 PPIIDGG-SPIINYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYG 19867

Query: 486   NYNCTAVNRIGQESLEFILVQADTPSSPSID-QVEPYS-STAQVQFDEPEATGGVPILKY 543
                      IG        V+A     P +D +V   S S+  + + +P + GG  I+ Y
Sbjct: 19868 ---------IGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGY 19918

Query: 544   -------KAEWRAVGEEVWHSKWYDAKEASMEGIVTI---------VGLKPETTYAVR-- 585
                    + +W+ V + +  S  Y AK+ +     T           G   E T   R  
Sbjct: 19919 VVDFLTEENKWQRVMKSL--SLQYSAKDLTEGKEYTFRVSAENENGEGTPSEITVVARDD 19976

Query: 586   --LAALNGKGLGEI----SAASEFKTQ-PVQGEPSAPKLEGQMGED 624
                  L+ KGL ++       S F+ + P++G+P AP +  + GED
Sbjct: 19977 VVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKP-APSVSWKKGED 20021



 Score = 36.6 bits (83), Expect = 0.10
 Identities = 24/82 (29%), Positives = 40/82 (48%), Gaps = 3/82 (3%)

Query: 228   GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED-DEKYIFSDDSSQLTIKKVDKNDEAEYI 286
             G ++ L    +G P P ++W+K    +      D K   +D  + L  + V+K D  +YI
Sbjct: 19708 GVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKS--TDFDTFLRCENVNKYDAGKYI 19765

Query: 287   CIAENKAGEQDATIHLKVFAKP 308
                EN  G+++ TI +KV   P
Sbjct: 19766 LTLENSCGKKEYTIVVKVLDTP 19787



 Score = 36.6 bits (83), Expect = 0.10
 Identities = 22/82 (26%), Positives = 36/82 (43%), Gaps = 5/82 (6%)

Query: 228   GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS-SQLTIKKVDKNDEAEYI 286
             G S T+     G P P + W+K    +        Y+ + DS + LTI+  ++ND  +Y 
Sbjct: 26201 GASFTMTVPFRGRPVPNVLWSKPDTDLRTRA----YVDTTDSRTSLTIENANRNDSGKYT 26256

Query: 287   CIAENKAGEQDATIHLKVFAKP 308
                +N       T+ +KV   P
Sbjct: 26257 LTIQNVLSAASLTLVVKVLDTP 26278



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 82/402 (20%), Positives = 150/402 (37%), Gaps = 84/402 (20%)

Query: 270   SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA----MELEEQV 325
             +Q  +  +   ++  +   A N AG  +  +       P +  VE + A    ++ E + 
Sbjct: 20731 TQFVVPDLQTKEKYNFRISAINDAGVGEPAVI------PDVEIVEREMAPDFELDAELRR 20784

Query: 326   TLTCEAS----------GDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHA 375
             TL   A           G P P +TW     NI+ + +A+    E               
Sbjct: 20785 TLVVRAGLSIRIFVPIKGRPAPEVTWTKD--NINLKNRANIENTES-------------- 20828

Query: 376   RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNIT 435
               + L +      D G+++ T  N  G+ S  + + V   P   GPV         +N+ 
Sbjct: 20829 -FTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTP---GPV---------LNLR 20875

Query: 436   CEVFAYPSATISW--------FRDGQLLPSSNYSNIKIYNTPSASY----LEVTPDSEND 483
                    S T+ W         R    +     +  K Y+T +        +VT  SE  
Sbjct: 20876 PTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGC 20935

Query: 484   FGNYNCTAVNRIG----QESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGV 538
                +   A N  G     E+ E +   ++ PS P S++ ++   ST  + + +P+  GG 
Sbjct: 20936 EYFFRVMAENEYGIGEPTETTEPVKA-SEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGS 20994

Query: 539   PILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIV-GLKPETTYAVRLAALNGKGLGEI 597
              I  Y  E +  G + W          +++G+  +V  L     Y  ++ A+N  G    
Sbjct: 20995 KITGYVIEAQRKGSDQW------THITTVKGLECVVRNLTEGEEYTFQVMAVNSAGR--- 21045

Query: 598   SAASEFKTQPVQGEPSAPKLEGQ-------MGEDGNSIKVNL 632
             SA  E +   V+ +   P+L+ +       + + G++IKV +
Sbjct: 21046 SAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEI 21087



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 53/239 (22%), Positives = 90/239 (37%), Gaps = 47/239 (19%)

Query: 199   INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
             +  +D++V+  +  +   ++ I       G+ V LV    G P P  SW   G ++ + E
Sbjct: 29727 VTVQDLRVLPTIDLSTMPQKTI---HVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESE 29783

Query: 259   DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
                    +   ++LTI++    D  EY    +N  G    TI + +  KP        T 
Sbjct: 29784 RVTVETHT-KVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKP-----GPPTG 29837

Query: 319   MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQ--ETLDGHMVVRSHAR 376
                 +++  T         SIT              SW  PE      L G++V +  A 
Sbjct: 29838 PIKIDEIDAT---------SIT-------------ISWEPPELDGGAPLSGYVVEQRDAH 29875

Query: 377   ----------VSSLTLKSIQYTDAGEYICTASNT----IGQDSQSMYLEVQYAPKLQGP 421
                       V+  T K  + T+  EY+   + T    IG   QS  +E + + ++ GP
Sbjct: 29876 RPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGP 29934



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 44/196 (22%), Positives = 71/196 (36%), Gaps = 17/196 (8%)

Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNN----YLQIRGIKKTDEGT 186
           EG  A     +     P + W   G+ VI    +  + +S +     L I  + K + G 
Sbjct: 19  EGSTATFEAHISGFPVPEVSWFRDGQ-VISTSTLPGVQISFSDGRAKLTIPAVTKANSGR 77

Query: 187 YRCE-----GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241
           Y  +     G+  +  E+  K        PP     Q + + T   G  V L     G P
Sbjct: 78  YSLKATNGSGQATSTAELLVK----AETAPPNFV--QRLQSMTVRQGSQVRLQVRVTGIP 131

Query: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301
            P + + +DG +I Q   D +     D   L I +    D   Y   A N  G   +T  
Sbjct: 132 TPVVKFYRDGAEI-QSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAE 190

Query: 302 LKVFAKPKITYVENQT 317
           L V  + ++   + +T
Sbjct: 191 LLVQGEEEVPAKKTKT 206



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 30/111 (27%), Positives = 51/111 (45%), Gaps = 12/111 (10%)

Query: 14   LGTAVSLQVDIVPSQGE-------ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQ 66
            L T+  L+++  P Q         +S  +S  F C+V+ D  D  ++W+    E LT +Q
Sbjct: 8821 LETSAELRIEAEPIQFTKRIQNIVVSEHQSATFECEVSFD--DAIVTWYKGPTE-LTESQ 8877

Query: 67   QRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQK 117
            +      ND     +TI+N   DD G+Y  +   E   E+ +T  + +  K
Sbjct: 8878 KYN--FRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARSTAELYLTTK 8926



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 29/112 (25%), Positives = 46/112 (41%), Gaps = 15/112 (13%)

Query: 510   PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 569
             P +P +  ++   S+  + +++P   GG  I  Y  E     E+ W      A   +   
Sbjct: 21759 PGNPRV--LDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATS- 21815

Query: 570   IVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQM 621
               TI GL     Y +R+ A+N +GLGE +             P  PK E +M
Sbjct: 21816 -YTITGLTENQEYKIRIYAMNSEGLGEPALV-----------PGTPKAEDRM 21855



 Score = 35.4 bits (80), Expect = 0.23
 Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 2/58 (3%)

Query: 636   DDGGSPIRHYLVRYR-ALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGK 692
             DDGGS I +Y+V  R   S++W P         H   K L+   +Y   V AENQ G+
Sbjct: 17335 DDGGSVITNYVVERRDVASAQWSPLSATSKKKSH-FAKHLNEGNQYLFRVAAENQYGR 17391



 Score = 34.3 bits (77), Expect = 0.51
 Identities = 95/448 (21%), Positives = 176/448 (39%), Gaps = 57/448 (12%)

Query: 31   ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
            +  G    F  +V G   D +  W+  NG K+     RI   W +D+   L I +   +D
Sbjct: 2089 VGQGSDAHFRVRVVGKP-DPECEWYK-NGVKIE-RSDRIYWYWPEDNVCELVIRDVTAED 2145

Query: 91   AG--IYKCV-VTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP- 146
            +   + K + + GE  S +   V  K  Q + F         +E +D +   +  +S P 
Sbjct: 2146 SASIMVKAINIAGETSSHAFLLVQAK--QLITFTQELQDVVAKE-KDTMATFECETSEPF 2202

Query: 147  PTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
              + W   G +V   +  ++ + S+   ++L I  I  +D   Y C   +L   E     
Sbjct: 2203 VKVKWYKDGMEV--HEGDKYRMHSDRKVHFLSILTIDTSDAEDYSC---VLVEDENVKTT 2257

Query: 204  IQVIVN--VPPTIQARQNIVNATANLGQSVTLVC--DAEGFPEPTMSWTKDGEQIEQEED 259
             ++IV   V   ++  Q+I    +  G+   +V   + EG       W  +   +E + +
Sbjct: 2258 AKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEG------KWYHN--DVELKSN 2309

Query: 260  DEKYIFSDDSSQ-LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
             +  I S    Q LT+K V K D+ EY  + + K      T  LK+  +P I  ++  + 
Sbjct: 2310 GKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGK----KTTCKLKMKPRP-IAILQGLSD 2364

Query: 319  MELEEQ--VTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHAR 376
             ++ E   V L  + S + +  + W    + +   ++              H+V+   + 
Sbjct: 2365 QKVCEGDIVQLEVKVSLESVEGV-WMKDGQEVQPSDRV-------------HIVIDKQSH 2410

Query: 377  VSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITC 436
            +  L ++ +   DAG Y  T    +G  S S  + V     +     V   EG +  + C
Sbjct: 2411 M--LLIEDMTKEDAGNYSFTIP-ALGL-STSGRVSVYSVDVITPLKDVNVIEGTKAVLEC 2466

Query: 437  EVFAYPSATISWF-RDGQLLPSSNYSNI 463
            +V      ++ W+  D Q+ P      I
Sbjct: 2467 KVSVPDVTSVKWYLNDEQIKPDDRVQAI 2494



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 24/93 (25%), Positives = 40/93 (43%), Gaps = 6/93 (6%)

Query: 510   PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 569
             PS P I  V+   +T  + + +P   GG PI  Y  E++   +  W +     +      
Sbjct: 26087 PSKPKI--VDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTE--- 26141

Query: 570   IVTIVGLKPETTYAVRLAALNGKGLGEISAASE 602
               TI GL     Y  R+ ++N  G  + S +S+
Sbjct: 26142 -YTISGLTTGAEYVFRVKSVNKVGASDPSDSSD 26173



 Score = 33.5 bits (75), Expect = 0.86
 Identities = 34/131 (25%), Positives = 53/131 (40%), Gaps = 6/131 (4%)

Query: 595   GEISAASEFKTQPVQGEPSAPKLEG-QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALS 653
             G+ +A    K   V G P   K+     G    S K+     DDGG  I+ Y++  R + 
Sbjct: 15898 GQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWKM---PDDDGGDRIKGYVIEKRTID 15954

Query: 654   SEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANG 713
              +   ++    GS   ++  L    +Y   V AEN+ G       + RT+A+    P + 
Sbjct: 15955 GKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPD- 16013

Query: 714   SPTSGLSTGAI 724
              P   L  G I
Sbjct: 16014 -PPIKLKIGLI 16023



 Score = 33.5 bits (75), Expect = 0.86
 Identities = 67/312 (21%), Positives = 119/312 (38%), Gaps = 43/312 (13%)

Query: 40    LCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT 99
             +C+V G  K   + W+   G+++  +  +  +         L I +   DDA +Y+   T
Sbjct: 30948 VCKVTGHPKPI-VKWYR-QGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRAT 31005

Query: 100   GEDGSES-----EATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHK 154
              + GS S     E  V  KI      +        R GE   I         P I W+ K
Sbjct: 31006 NQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALR-GEVVSIKIPFSGKPDPVITWQ-K 31063

Query: 155   GRDVILKKDVRFIVLSNNYLQI---RGIKKTDEGTYRCEGRILARGEINFKDIQV-IVNV 210
             G+D+I       ++++ ++  +    G+++ D G Y    +   R  I+ K +++ + +V
Sbjct: 31064 GQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAK--NRFGIDQKTVELDVADV 31121

Query: 211   P------PTIQARQNIVNAT----ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
             P            ++ VN T    A+ G S       E        W + G+  E     
Sbjct: 31122 PDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARE----- 31176

Query: 261   EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME 320
                      ++ T+  +      ++  IAENK G    +      ++P IT  +   AM 
Sbjct: 31177 ---------TRYTVINLFGKTSYQFRVIAENKFGLSKPSEP----SEPTITKEDKTRAMN 31223

Query: 321   LEEQVTLTCEAS 332
              +E+V  T E S
Sbjct: 31224 YDEEVDETREVS 31235



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 67/287 (23%), Positives = 107/287 (37%), Gaps = 46/287 (16%)

Query: 451   DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 510
             DG+ L   NY+NI+       +Y EVT  +E+    +   A N     S      +    
Sbjct: 25728 DGRWL-KCNYTNIQ------ETYFEVTELTEDQRYEFRVFARNAADSVS------EPSES 25774

Query: 511   SSPSI--DQVEPYSSTAQVQFDEPEATGGVPILKYKAE----------WRAVGEEVWHSK 558
             + P I  D VEP      V+F +        +LK  A+          W   G E+    
Sbjct: 25775 TGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERA 25834

Query: 559   WYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAP-KL 617
               +        ++T+       T    L   N  G   ++   +   +P  G P+ P ++
Sbjct: 25835 RTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKP--GPPAGPLEI 25892

Query: 618   EGQMGEDGNSIKVNLI---KQDDGGSPIRHYLVRYRALSS-EW---KPEIRLPSGSDHVM 670
              G   E     K +L     Q+DGG+ I +Y+V  R  S   W   + E+++ S     +
Sbjct: 25893 NGLTAE-----KCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKL 25947

Query: 671   LKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTS 717
             LK      EY   V   N+ G  +    V   +  P  +P+   PTS
Sbjct: 25948 LK----GNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPS--PPTS 25988



 Score = 31.2 bits (69), Expect = 4.3
 Identities = 63/292 (21%), Positives = 106/292 (36%), Gaps = 36/292 (12%)

Query: 356   WTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYA 415
             WT+ E +   D  +V+ +    S L +K     D G Y+ TA+N+ G    +  +EV   
Sbjct: 15138 WTKEEGELDKD-RVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDV 15196

Query: 416   PKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF---RDG-----QLLPSSNYSNIKIYN 467
             P   GPV         +++   V       ++W     DG       +     + +  + 
Sbjct: 15197 P---GPV---------LDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWR 15244

Query: 468   TP---SASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQADTPSSP-----SIDQV 518
              P     S  ++T   E     +   A N+ G    +E   + A  P  P      +   
Sbjct: 15245 QPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYT 15304

Query: 519   EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKP 578
             E   ST  + + EP + GG PI  Y  E R   +  +       K         +  L  
Sbjct: 15305 ERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERV---NKRLCPTTSFLVENLDE 15361

Query: 579   ETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKV 630
                Y  R+ A+N  G  E S         +Q +   P ++ ++   G++IKV
Sbjct: 15362 HQMYEFRVKAVNEIGESEPSLPLNV---VIQDDEVPPTIKLRLSVRGDTIKV 15410


>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
            precursor [Homo sapiens]
          Length = 2012

 Score =  144 bits (362), Expect = 5e-34
 Identities = 168/708 (23%), Positives = 290/708 (40%), Gaps = 49/708 (6%)

Query: 27   SQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSS--STLTIY 84
            S+  +S  E    +C V G      I+W   +   L     RIS +   + +  S L I 
Sbjct: 414  SEKVVSPAEPVSLMCNVKGTPLPT-ITWTLDDDPILKGGSHRISQMITSEGNVVSYLNIS 472

Query: 85   NANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLM-FKNAPTPQEFREGEDAVIVCDVV 142
            ++ + D G+Y+C      G    +A +NV+    +   KN         G D  I C V+
Sbjct: 473  SSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIA----GRDTYIHCRVI 528

Query: 143  SSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK-TDEGTYRCEGRILARGEINF 201
                 +I W +K  +++     +    +N  L++  ++K  DEG Y C   +L + +++ 
Sbjct: 529  GYPYYSIKW-YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCN--VLVQPQLST 585

Query: 202  -KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEP-TMSWTKDGEQIEQEED 259
             + + V V VPP IQ  +       ++GQ V + C       P T++W KDG  I     
Sbjct: 586  SQSVHVTVKVPPFIQPFEF---PRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLG 642

Query: 260  DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
                   D +S L I  +       Y CIA N+A   +    L V   PK          
Sbjct: 643  -VTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDG 701

Query: 320  ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS 379
               + V L C A G P+P+I W+ S        K +     +   L+G + V S+    S
Sbjct: 702  IYGKAVILNCSAEGYPVPTIVWKFS--------KGAGVPQFQPIALNGRIQVLSNG---S 750

Query: 380  LTLKSIQYTDAGEYICTASNTIGQD-SQSMYLEVQYAPKLQG-PVAVYTWEGNQVNITCE 437
            L +K +   D+G Y+C  SN +G D S+SMYL V+    +   P      +G +  ++C 
Sbjct: 751  LLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCT 810

Query: 438  VFAYPSATISWFRDGQLLP---SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNR 494
                    + W ++ +++    +    + K       S L++ P    D G ++C A+N 
Sbjct: 811  AHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINS 870

Query: 495  IGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEV 554
             G++     L   + P  P I+  +  + T  +++      G  PI  Y  E +   +  
Sbjct: 871  YGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRW-TMGFDGNSPITGYDIECKNKSDS- 928

Query: 555  WHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSA 614
            W S       +      TI+ + P +TY++R+ A N   +G+   ++E      +  P  
Sbjct: 929  WDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKN--RIGKSEPSNELTITADEAAPDG 986

Query: 615  PKLEGQMGE-DGNSIKV--NLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPS-----GS 666
            P  E  +      SI+V     K+      IR Y + YR  S+    +  + S      S
Sbjct: 987  PPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDS 1046

Query: 667  DHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQ--PTAIPAN 712
            +   L +L+   +Y + V A N+ G   ++  +  T+ +  P+  P N
Sbjct: 1047 EVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPEN 1094



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 97/418 (23%), Positives = 165/418 (39%), Gaps = 39/418 (9%)

Query: 87  NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPT------PQEFREGEDAVIVCD 140
           N D    Y+C+       E+  + + ++F      +AP+       ++   G+   + C 
Sbjct: 188 NEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCK 247

Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195
            +    P   W      + L    +  V     L I  I+ +D G+Y CE     G    
Sbjct: 248 ALGHPEPDYRWLKDNMPLELSGRFQKTVTG---LLIENIRPSDSGSYVCEVSNRYGTAKV 304

Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
            G +  K       +  TI  R+      +++G  V+L C   G  +  +SW ++GE + 
Sbjct: 305 IGRLYVKQ-----PLKATISPRK----VKSSVGSQVSLSCSVTGTEDQELSWYRNGEILN 355

Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC-IAENKAGEQDATIHLKVFAKPKITYVE 314
             ++    I   +   L +  + K+D   Y C + ++K   QD    +     PKI    
Sbjct: 356 PGKNVR--ITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAF 413

Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSH 374
           ++  +   E V+L C   G P+P+ITW      I    K    R  +  T +G++V    
Sbjct: 414 SEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPIL---KGGSHRISQMITSEGNVV---- 466

Query: 375 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNI 434
              S L + S Q  D G Y CTA+N+ G       + V+    ++    +    G    I
Sbjct: 467 ---SYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYI 523

Query: 435 TCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 492
            C V  YP  +I W+++  LLP  N+  +   N  +    +V    E D G Y C  +
Sbjct: 524 HCRVIGYPYYSIKWYKNSNLLP-FNHRQVAFENNGTLKLSDV--QKEVDEGEYTCNVL 578



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 95/413 (23%), Positives = 143/413 (34%), Gaps = 31/413 (7%)

Query: 94  YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
           Y C      G      V++K   +  +      Q+   G  AV  C + SS+   I    
Sbjct: 100 YYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVS 159

Query: 154 KGRDVI-LKKDVRFIVLSNNYLQIRGIKKTDE-GTYRCEGRILARGEINFKDIQVIVNVP 211
             +D + L    RF++ S   L I+ ++  D    YRC  R    GE    +   +    
Sbjct: 160 WEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSD 219

Query: 212 PTIQARQ---NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
           P   A        +  A  GQ V L C A G PEP   W KD   +E     +K +    
Sbjct: 220 PANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTV---- 275

Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
            + L I+ +  +D   Y+C   N+ G       L V    K T    +    +  QV+L+
Sbjct: 276 -TGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLS 334

Query: 329 CEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYT 388
           C  +G     ++W  +   ++  +    T    +  +  HMV                 +
Sbjct: 335 CSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMV----------------KS 378

Query: 389 DAGEYIC--TASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATI 446
           D G Y C         QD   + LE      +             V++ C V   P  TI
Sbjct: 379 DGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTI 438

Query: 447 SWFRDGQLLPSSNYSNIKIYNTPS---ASYLEVTPDSENDFGNYNCTAVNRIG 496
           +W  D   +       I    T      SYL ++     D G Y CTA N  G
Sbjct: 439 TWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAG 491



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 95/365 (26%), Positives = 147/365 (40%), Gaps = 34/365 (9%)

Query: 397  ASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN-------QVNITCEVFAYPSATISWF 449
            A  + G+ + S  + V+  P  + P  + T+ G         + + C+    PS  + W 
Sbjct: 1263 AVTSAGRGNSSEIITVE--PLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM 1320

Query: 450  RDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADT 509
            +D    PS    + +     + S++  T  +E D G Y+C A N  G + +   L     
Sbjct: 1321 KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAE-DSGYYSCIANNNWGSDEIILNLQVQVP 1379

Query: 510  PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 569
            P  P +   +  SS+  + +  P   GG  I  Y  ++     E W S      E S   
Sbjct: 1380 PDQPRLTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYR- 1437

Query: 570  IVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNS-I 628
               +  LK  T Y   L A NG G G IS   E KT  +  EP   K +        + +
Sbjct: 1438 ---LENLKCGTWYKFTLTAQNGVGPGRISEIIEAKT--LGKEPQFSKEQELFASINTTRV 1492

Query: 629  KVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAEN 688
            ++NLI  +DGG PI  + + YR   +      +  S S   +L  L     YE+ +   N
Sbjct: 1493 RLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCN 1552

Query: 689  QQG-KSKAAHFV---FRTSAQPTAIPANGSPTSGLSTG-----------AIVGILIVIFV 733
              G   K A+F    +  S  P  I +      GL+T             +VG+L+ +FV
Sbjct: 1553 SAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLL-LFV 1611

Query: 734  LLLVV 738
            LLLVV
Sbjct: 1612 LLLVV 1616



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 86/385 (22%), Positives = 139/385 (36%), Gaps = 78/385 (20%)

Query: 266  SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDA----TIHLKVFAKPKITYVENQTAMEL 321
            S DS    I  + +N +     +A   AG  ++    T+     A  +I           
Sbjct: 1240 SPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPW 1299

Query: 322  EEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLT 381
             + + L C+A GDP P++ W   +    S             T+DG   + S+    S  
Sbjct: 1300 MKDIVLPCKAVGDPSPAVKWMKDSNGTPS-----------LVTIDGRRSIFSNG---SFI 1345

Query: 382  LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAY 441
            +++++  D+G Y C A+N  G D   + L+VQ  P             +Q  +T      
Sbjct: 1346 IRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP-------------DQPRLTVSKTTS 1392

Query: 442  PSATISWFRDGQLLPSSN-YSNIKIY-------NTPSASYLEVTPDSEN---------DF 484
             S T+SW      LP  N  S+I+ Y       N+       ++P   +          +
Sbjct: 1393 SSITLSW------LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTW 1446

Query: 485  GNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEAT--------- 535
              +  TA N +G   +  I ++A T         EP  S  Q  F     T         
Sbjct: 1447 YKFTLTAQNGVGPGRISEI-IEAKTLGK------EPQFSKEQELFASINTTRVRLNLIGW 1499

Query: 536  --GGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG 593
              GG PI  +  E+R  G  VW +    A+  S+     +  L+  T Y +++   N  G
Sbjct: 1500 NDGGCPITSFTLEYRPFGTTVWTT----AQRTSLSKSYILYDLQEATWYELQMRVCNSAG 1555

Query: 594  LGEISAASEFKTQPVQGEPSAPKLE 618
              E  A   F T    G    P ++
Sbjct: 1556 CAEKQA--NFATLNYDGSTIPPLIK 1578



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 32/108 (29%), Positives = 47/108 (43%), Gaps = 8/108 (7%)

Query: 207  IVNVPPTIQARQNIVNATANLG----QSVTLVCDAEGFPEPTMSWTKD--GEQIEQEEDD 260
            I+ V P  +A   I+  +  +     + + L C A G P P + W KD  G       D 
Sbjct: 1275 IITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDG 1334

Query: 261  EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
             + IFS+ S    I+ V   D   Y CIA N  G  +  ++L+V   P
Sbjct: 1335 RRSIFSNGS--FIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP 1380



 Score = 35.0 bits (79), Expect = 0.30
 Identities = 26/103 (25%), Positives = 43/103 (41%), Gaps = 8/103 (7%)

Query: 133  EDAVIVCDVVSSLPPTIIWKH--KGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190
            +D V+ C  V    P + W     G   ++  D R  + SN    IR +K  D G Y C 
Sbjct: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSC- 1359

Query: 191  GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTL 233
               +A    N+   ++I+N+   +   Q  +  +     S+TL
Sbjct: 1360 ---IANN--NWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITL 1397


>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
          Length = 1447

 Score =  142 bits (358), Expect = 1e-33
 Identities = 170/666 (25%), Positives = 262/666 (39%), Gaps = 87/666 (13%)

Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLS 170
           +K F  L F + P+      G + ++ C   S    P I WK  G  + L  D R   LS
Sbjct: 34  IKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLS 93

Query: 171 NNYLQIRGI-----KKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATA 225
           N  L I+ I      K DEG Y+CE  +   G I  +  +V V  P    ++   V  TA
Sbjct: 94  NGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESV--TA 151

Query: 226 NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEY 285
            +G +V L C+  G P PT+ W K+ + +     D + +    S  L I ++   D   Y
Sbjct: 152 FMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLP-SGALQISRLQPGDIGIY 210

Query: 286 ICIAENKAGEQDAT-IHLKVFAKP----KITYVE---NQTAMELEEQVTLTCEASGDPIP 337
            C A N A  +      +++ + P    ++ +++   N  A+E ++ V L C  SG P P
Sbjct: 211 RCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAV-LECCVSGYPPP 269

Query: 338 SITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA 397
           S TW          E+    R +K   L G          S+L + ++   D+G Y C  
Sbjct: 270 SFTWLRG-------EEVIQLRSKKYSLLGG----------SNLLISNVTDDDSGMYTCVV 312

Query: 398 SNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 456
           +      S S  L V   P  L  P  +Y +E   +   C V   P  T++W ++G ++ 
Sbjct: 313 TYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVI 372

Query: 457 SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG--QESLEFILVQADTPSSPS 514
            S+Y     +     S L +    ++D G Y C A N  G  Q S + I+ +   PSS  
Sbjct: 373 PSDY-----FQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSV 427

Query: 515 I-----DQVEPYSSTAQVQFD---EPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEAS 566
           +     D V    S+  V+       EA G +               V+ S+  D +E +
Sbjct: 428 LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTF-----------TVFFSREGDNRERA 476

Query: 567 MEGI------VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQ 620
           +         +T+  LKPE  Y  R+ A N  G GE S   +  TQP    P   +    
Sbjct: 477 LNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQA 536

Query: 621 MGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEY 680
           +     SI +          P++ Y +    +S+  +  I +   S    L+ L    EY
Sbjct: 537 VSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLS--YKLEGLKKFTEY 594

Query: 681 EVYVVAENQQGKSKAAH--FVFRTSAQPTAIPANGS---------------PTSGLSTGA 723
            +  +A N+ G   +     V   S  P+A P N S               P SG   G 
Sbjct: 595 SLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGF 654

Query: 724 IVGILI 729
           I G  I
Sbjct: 655 ITGYKI 660



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 146/632 (23%), Positives = 227/632 (35%), Gaps = 69/632 (10%)

Query: 90  DAGIYKCVVT-GEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPT 148
           D G+Y+C  + G+ GS    T  V +   L F +         G+  ++ C+V+    PT
Sbjct: 111 DEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPT 170

Query: 149 IIWKHKGRDVI-LKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
           I W+   +D+  +  D R +VL +  LQI  ++  D G YRC  R  A       + +V 
Sbjct: 171 IHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTG-NEAEVR 229

Query: 208 VNVPPTIQAR----QNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
           +   P +  +    Q   N  A  G+   L C   G+P P+ +W + GE++ Q    +  
Sbjct: 230 ILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GEEVIQLRSKKYS 288

Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP-KITYVENQTAMELE 322
           +     S L I  V  +D   Y C+   K     A+  L V   P  + +  N  A E  
Sbjct: 289 LLG--GSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYE-S 345

Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSH----ARVS 378
             +   C  SG P+P++ W                        +G +V+ S        S
Sbjct: 346 MDIEFECTVSGKPVPTVNWMK----------------------NGDVVIPSDYFQIVGGS 383

Query: 379 SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----------QYAPKLQGPVAVYTW 427
           +L +  +  +D G Y C A N  G    S  L V             AP+   PV V   
Sbjct: 384 NLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLV--- 440

Query: 428 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 487
               V ++    A     I  F         N         P +  L V          +
Sbjct: 441 SSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTF 500

Query: 488 NCTAVNRIGQ-ESLEFILV----QADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 542
              A N  G  ES + I V    +   P      Q    S T+ +   EP A    P+  
Sbjct: 501 RVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQG 560

Query: 543 YKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 602
           Y+     V      +   D     +E      GLK  T Y++R  A N  G G   +  +
Sbjct: 561 YRLFCTEVSTGKEQNIEVDGLSYKLE------GLKKFTEYSLRFLAYNRYGPG--VSTDD 612

Query: 603 FKTQPVQGEPSAPKLEGQMG-EDGNSIKVNLIKQDDG--GSPIRHYLVRYRALSSEWKPE 659
                +   PSAP     +   +  SIKV+ +    G     I  Y +R+R  +   + E
Sbjct: 613 ITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEME 672

Query: 660 IRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 691
              P+   + +   L+  ++Y   V A    G
Sbjct: 673 TLEPNNLWY-LFTGLEKGSQYSFQVSAMTVNG 703



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 66/256 (25%), Positives = 118/256 (46%), Gaps = 26/256 (10%)

Query: 79  STLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
           S L I N   DD+G+Y CVVT ++ + S A+  + +     F N P+     E  D    
Sbjct: 293 SNLLISNVTDDDSGMYTCVVTYKNENIS-ASAELTVLVPPWFLNHPSNLYAYESMDIEFE 351

Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE 198
           C V     PT+ W   G DV++  D  F ++  + L+I G+ K+DEG Y+C    +A  E
Sbjct: 352 CTVSGKPVPTVNWMKNG-DVVIPSDY-FQIVGGSNLRILGVVKSDEGFYQC----VAENE 405

Query: 199 INFKDIQVIVNVP-PTIQARQNIVNATANL------GQSVTL----VCDAEGFPEP-TMS 246
                    + VP P I +   + +A  ++       + V L      +A+G  +  T+ 
Sbjct: 406 AGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVF 465

Query: 247 WTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306
           ++++G+  E+  +  +      S QLT+  +       +  +A N+ G  +++  +KV  
Sbjct: 466 FSREGDNRERALNTTQ----PGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVAT 521

Query: 307 KPKITY---VENQTAM 319
           +P++     VEN  A+
Sbjct: 522 QPELQVPGPVENLQAV 537



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 1/70 (1%)

Query: 573  IVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGN-SIKVN 631
            I+ L  +T Y  R+ A N KG+G +S    F+T  V+        +G+ G+ G   +  N
Sbjct: 1009 IMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTN 1068

Query: 632  LIKQDDGGSP 641
            LI +     P
Sbjct: 1069 LIDRSTLNEP 1078


>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
           sapiens]
          Length = 1386

 Score =  142 bits (358), Expect = 1e-33
 Identities = 154/631 (24%), Positives = 239/631 (37%), Gaps = 74/631 (11%)

Query: 31  ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANI-- 88
           +S GE     C+  G  +  +I W+         N  R++ V  D  +  L + +  +  
Sbjct: 75  VSRGEPATLPCRAEGRPRP-NIEWYK--------NGARVATVREDPRAHRLLLPSGALFF 125

Query: 89  ----------DDAGIYKCVVTGEDGSESEATVNVKI-FQKLMFKNAPTPQEFREGEDAVI 137
                      D G+Y CV     G+ +    ++++   +  F+ +P       GE AV+
Sbjct: 126 PRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVL 185

Query: 138 VCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
            C      P P++ W+  G    LK++   I +    L +    K+D G Y C    +A 
Sbjct: 186 ECVPPRGHPEPSVSWRKDGAR--LKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMA- 242

Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
           GE      +V+V   P+   R   VN        VT +C+ +G P P + W K+    + 
Sbjct: 243 GERESAAAEVMVLERPSFLRRP--VNQVVLADAPVTFLCEVKGDPPPRLRWRKE----DG 296

Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
           E    +Y    D S L I  V   DE  Y C+AEN  G  +A+  L V   P++      
Sbjct: 297 ELPTGRYEIRSDHS-LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQD 355

Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHAR 376
                 E V   CE  G+P P+I W+        E       P +     G   V    +
Sbjct: 356 QMAAPGESVAFQCETKGNPPPAIFWQ-------KEGSQVLLFPSQSLQPTGRFSVSPRGQ 408

Query: 377 VSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-------LQGPVAVYTWEG 429
              L + ++Q  DAG Y+C A +  G       LE++ A         LQGP       G
Sbjct: 409 ---LNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLG 465

Query: 430 NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 489
           + V + C V   P  ++ W +DGQ L   +      + T +   L +    E D G Y+C
Sbjct: 466 SSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQ----FKTMANGTLYIANVQEMDMGFYSC 521

Query: 490 TAVNRIGQESLEFIL-------VQADTPSSPSIDQVEP-------YSSTAQVQFDEPEAT 535
            A +  G+ +    L       V  D P+ PS     P        +  +     +P   
Sbjct: 522 VAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQ 581

Query: 536 GGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLG 595
            G  +  Y  E          + W    +       T+ GL+P T Y   + A+   GL 
Sbjct: 582 TGAAVTSYVIE---AFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLS 638

Query: 596 EISAASE-FKTQPVQGEPSAPKLEGQMGEDG 625
           E S  SE  +TQ     PS P  +   G+ G
Sbjct: 639 EPSPVSEPVRTQ--DSSPSRPVEDPWRGQQG 667


>gi|157311649 neogenin homolog 1 [Homo sapiens]
          Length = 1461

 Score =  140 bits (353), Expect = 5e-33
 Identities = 163/639 (25%), Positives = 253/639 (39%), Gaps = 82/639 (12%)

Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
           +++ F    F   P       G   ++ C   S   P I WK  G  + L  D R  +L 
Sbjct: 46  SIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLP 105

Query: 171 NNYLQIRGI-----KKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATA 225
           +  L I  +      K DEG Y+C   + + G I  +  ++IV   P   ++    +  A
Sbjct: 106 DGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYA 165

Query: 226 NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEY 285
             G +  L C+      P + W    EQ  Q    +  +    S  L I    + D   Y
Sbjct: 166 --GNNAILNCEVNADLVPFVRW----EQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLY 219

Query: 286 ICIAENKA-GEQDATIHLKVFAKPKI----TYVENQTAM--ELEEQVTLTCEASGDPIPS 338
            C+ E+    +    + LKV   P++     +++  + +   + + V L C ASG P P+
Sbjct: 220 RCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPT 279

Query: 339 ITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 398
           I W      + +EE       E+   L G           SL +  +   DAG Y C A 
Sbjct: 280 IKW------MKNEEALDTESSERLVLLAG----------GSLEISDVTEDDAGTYFCIAD 323

Query: 399 NTIGQDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQL-LP 456
           N          L VQ  P+ L+ P  +Y  E   +   CEV   P+ T+ W ++G + +P
Sbjct: 324 NGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIP 383

Query: 457 SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG--QESLEFILVQ---ADTPS 511
           S  +  +K +N      L+V    ++D G Y C A N +G  Q   + I+++   A T  
Sbjct: 384 SDYFKIVKEHN------LQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437

Query: 512 SPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV-----GEEVWHSKWYDAKEAS 566
            PS  + +  +S    +F              K  WR       G+ + +S +Y  +  +
Sbjct: 438 LPSAPR-DVVASLVSTRF-------------IKLTWRTPASDPHGDNLTYSVFYTKEGIA 483

Query: 567 MEGI----------VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP-VQGEPSAP 615
            E +          VTI  L P T Y  R+ A N  G GE SA    +TQP VQ    AP
Sbjct: 484 RERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAP 543

Query: 616 KLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLD 675
            L         SI V       G   I++Y + Y    ++ + ++ + S S    +  L 
Sbjct: 544 NLRAYAASP-TSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHS--YTINGLK 600

Query: 676 WNAEYEVYVVAENQQGKSKAAHFV-FRT-SAQPTAIPAN 712
              EY   VVA N+ G   +   V  RT S  P+A P N
Sbjct: 601 KYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQN 639



 Score =  109 bits (273), Expect = 9e-24
 Identities = 157/731 (21%), Positives = 269/731 (36%), Gaps = 93/731 (12%)

Query: 10  TLFFLGTAVSLQVDIV----------PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNG 59
           T+  LGT +S    ++          P    +  G +    C+V  D     + W   N 
Sbjct: 132 TVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPF-VRW-EQNR 189

Query: 60  EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG------EDGSESEATVNVK 113
           + L  + + I +      S  L I NA   D G+Y+CVV         D  E +   + +
Sbjct: 190 QPLLLDDRVIKL-----PSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPE 244

Query: 114 IFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNN 172
           +   L+F   P+P     G+D V+ C V S LP PTI W      +  +   R ++L+  
Sbjct: 245 VISDLVFLKQPSPLVRVIGQDVVLPC-VASGLPTPTIKWMKNEEALDTESSERLVLLAGG 303

Query: 173 YLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVT 232
            L+I  + + D GTY C    +A       + Q  + V    +  +   N  A+    + 
Sbjct: 304 SLEISDVTEDDAGTYFC----IADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIV 359

Query: 233 LVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENK 292
             C+  G P PT+ W K+G+ +   +    Y        L +  + K+DE  Y CIAEN 
Sbjct: 360 FECEVTGKPTPTVKWVKNGDMVIPSD----YFKIVKEHNLQVLGLVKSDEGFYQCIAEND 415

Query: 293 AGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEE 352
            G   A   L +      T     +A        +           +TWRT   +   + 
Sbjct: 416 VGNAQAGAQLIILEHAPATTGPLPSAPR-----DVVASLVSTRFIKLTWRTPASDPHGDN 470

Query: 353 KASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 412
                   K+      +   SH     +T++++       +   A N  G    S  L V
Sbjct: 471 LTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV 530

Query: 413 QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSAS 472
           +  P++Q P       G   N+     +  S T++W  +  +  +    N K+Y      
Sbjct: 531 ETQPEVQLP-------GPAPNLRAYAASPTSITVTW--ETPVSGNGEIQNYKLY------ 575

Query: 473 YLEVTPDSENDFG----NYNCTAVNRIGQESLEFILVQADTP--SSP--------SIDQV 518
           Y+E   D E D      +Y    + +  + S   +      P  S+P         +   
Sbjct: 576 YMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSA 635

Query: 519 EPYSSTAQVQFDE---------PEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 569
            P + + +V+  +           AT    I  YK  +R        S+  D  E  + G
Sbjct: 636 APQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKA------SRKSDVTETLVSG 689

Query: 570 I---VTIVGLKPETTYAVRLAALNGKGLGEIS---AASEFKTQPVQGEPSAPKLEGQMGE 623
                 I GL   T Y  R+AAL   G G  +   +A  F++     E   P++   +  
Sbjct: 690 TQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESD--LDETRVPEVPSSLHV 747

Query: 624 DG--NSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYE 681
                SI V+    ++    +R Y + Y  + S     I++     +  +++LD ++ Y 
Sbjct: 748 RPLVTSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTIKVDYKQRYYTIENLDPSSHYV 806

Query: 682 VYVVAENQQGK 692
           + + A N  G+
Sbjct: 807 ITLKAFNNVGE 817



 Score = 35.4 bits (80), Expect = 0.23
 Identities = 73/332 (21%), Positives = 118/332 (35%), Gaps = 60/332 (18%)

Query: 336  IPSITWRTSTRNISSEEKASWTRPEKQETLD-----GHMVVRSHARVSSLTLKSIQYT-- 388
            +P +      R + +    SWT PE Q  +      G+ +   HA+   +  K   YT  
Sbjct: 738  VPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIE 797

Query: 389  ---DAGEYICT--ASNTIGQ--------------DSQSMYLEVQYAPKLQGPVAVYTWEG 429
                +  Y+ T  A N +G+              D+  + L V  AP    PV   T   
Sbjct: 798  NLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYT--PVPDPTPMM 855

Query: 430  NQVNITCEVFAYPSATISWFRDG----QLLPSSNYSNI------------KIYNTPSASY 473
              V +   + ++ +  I+W  +     Q +  S Y  +            K  N  + SY
Sbjct: 856  PPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSY 915

Query: 474  LE--VTPDSENDFGNYNCTAVNRIGQESLE-----FILVQADTPSSPSIDQVEPYSSTAQ 526
            L   + P++  +F +   T   R    S+      F LV    P   ++   E    T  
Sbjct: 916  LVTGLKPNTLYEF-SVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTII 974

Query: 527  VQFDEP-EATGGVP--ILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYA 583
            V +  P EA G +   I+ Y  +   V  E+    W             I  L  +T Y 
Sbjct: 975  VNWQPPSEANGKITGYIIYYSTD---VNAEI--HDWVIEPVVGNRLTHQIQELTLDTPYY 1029

Query: 584  VRLAALNGKGLGEISAASEFKTQPVQGEPSAP 615
             ++ A N KG+G +S A +F+T         P
Sbjct: 1030 FKIQARNSKGMGPMSEAVQFRTPKADSSDKMP 1061


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score =  137 bits (344), Expect = 6e-32
 Identities = 112/394 (28%), Positives = 164/394 (41%), Gaps = 41/394 (10%)

Query: 26  PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
           P   +++ G + +F C+  G+ K  +I W   N E       R++++  DD   TL I N
Sbjct: 252 PQDADVTSGNTVYFTCRAEGNPKP-EIIWLRNNNELSMKTDSRLNLL--DDG--TLMIQN 306

Query: 86  ANIDDAGIYKCVVTGEDGSESEATVNVKIF---QKLMFKNAPTPQEFREGEDAVIVCDVV 142
               D GIY+C+     G      V ++ F    +  F   P   E   GE   + C   
Sbjct: 307 TQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSAT 366

Query: 143 SSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEG--RILARGEIN 200
              PP I W  +G    L  D R  +  +  L I+ + + D G Y C     I +     
Sbjct: 367 GHPPPRISWT-RGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATA 425

Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
           F  +Q +     T Q R  I       GQ+V   C+A+G P P ++WTK G Q+     D
Sbjct: 426 FIIVQALPQFTVTPQDRVVIE------GQTVDFQCEAKGNPPPVIAWTKGGSQLSV---D 476

Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVENQTA 318
            +++    S  L I  V  +D+ +Y C A N  G Q    HL V  +  P    + + T 
Sbjct: 477 RRHLVLS-SGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535

Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVS 378
           +E+   V L C + G+P P+ITW      ++   K   + PE                  
Sbjct: 536 VEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHIS-PE-----------------G 577

Query: 379 SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 412
            LT+  +   DAG Y C A NTIG  S SM L V
Sbjct: 578 FLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611



 Score =  135 bits (340), Expect = 2e-31
 Identities = 108/388 (27%), Positives = 161/388 (41%), Gaps = 37/388 (9%)

Query: 124 PTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTD 183
           P   +   G      C    +  P IIW     ++ +K D R  +L +  L I+  ++TD
Sbjct: 252 PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETD 311

Query: 184 EGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIV----NATANLGQSVTLVCDAEG 239
           +G Y+C  + +A GE+  +++ +     P   AR   V    N    +G+SVTL C A G
Sbjct: 312 QGIYQCMAKNVA-GEVKTQEVTLRYFGSP---ARPTFVIQPQNTEVLVGESVTLECSATG 367

Query: 240 FPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDAT 299
            P P +SWT+ G++     D    I    S  L I+ V + D  EY C A N      AT
Sbjct: 368 HPPPRISWTR-GDRTPLPVDPRVNI--TPSGGLYIQNVVQGDSGEYACSATNNIDSVHAT 424

Query: 300 IHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRP 359
             + V A P+ T       +   + V   CEA G+P P I W      +S + +      
Sbjct: 425 AFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRR------ 478

Query: 360 EKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ--YAPK 417
                   H+V+ S     +L +  +   D G+Y C A N IG      +L VQ    P 
Sbjct: 479 --------HLVLSS----GTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPV 526

Query: 418 LQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEV 476
                +  T E G  V + C     P   I+W +DG  +  S     K + +P   +L +
Sbjct: 527 FASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESG----KFHISPE-GFLTI 581

Query: 477 TPDSENDFGNYNCTAVNRIGQESLEFIL 504
                 D G Y C A N IG  S+  +L
Sbjct: 582 NDVGPADAGRYECVARNTIGSASVSMVL 609



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 58/208 (27%), Positives = 83/208 (39%), Gaps = 28/208 (13%)

Query: 307 KPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLD 366
           +P+IT       +     V  TC A G+P P I W  +   +S +  +      +   LD
Sbjct: 245 RPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDS------RLNLLD 298

Query: 367 GHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQ-DSQSMYLEVQYAPK----LQGP 421
                       +L +++ Q TD G Y C A N  G+  +Q + L    +P     +  P
Sbjct: 299 D----------GTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQP 348

Query: 422 VAVYTWEGNQVNITCEVFAYPSATISWFR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDS 480
                  G  V + C    +P   ISW R D   LP     NI    TPS   L +    
Sbjct: 349 QNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNI----TPSGG-LYIQNVV 403

Query: 481 ENDFGNYNCTAVNRIGQ-ESLEFILVQA 507
           + D G Y C+A N I    +  FI+VQA
Sbjct: 404 QGDSGEYACSATNNIDSVHATAFIIVQA 431


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score =  136 bits (342), Expect = 9e-32
 Identities = 129/501 (25%), Positives = 200/501 (39%), Gaps = 58/501 (11%)

Query: 31   ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
            ++VGE    +C+ +G    + I W+    E +   +          SS  L I  A   D
Sbjct: 592  VAVGEEAVLVCEASGVPPPRVI-WYRGGLEMILAPE--------GSSSGKLRIPAAQERD 642

Query: 91   AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
            AG Y C    E G  S A + + +         P       G  A++ C      PPT+ 
Sbjct: 643  AGTYTCRAVNELGDAS-AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVT 701

Query: 151  WKH-KGRDVILK----KDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQ 205
            W+   G+ + L+    +  R     +  L    +   D+  Y CE R +  G++  +   
Sbjct: 702  WRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF-GKVQAEARL 760

Query: 206  VIV-NVPPTIQARQNIVNATANLGQSVTLVCDA-EGFPEPTMSWTKDGEQIEQEEDDEKY 263
            ++  + PP I +    V      GQ V+L C    G P P   W KDG  +       ++
Sbjct: 761  IVTGHAPPQIASSAPTVRVLE--GQPVSLPCIVLAGRPLPERHWLKDGRPLPP---GSRH 815

Query: 264  IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEE 323
                D S L + +  +     Y C+A N AG Q   + L V   P+I             
Sbjct: 816  SIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGV 874

Query: 324  QVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLK 383
              +L C ASG P P+ITW   T  ++S        P    + +G +++   +        
Sbjct: 875  PASLPCVASGVPAPTITWTKETNALTSRG------PHYNVSKEGTLLIAQPSA------- 921

Query: 384  SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL--------QGPVAVYTWEGNQVNIT 435
                 DAG Y+CTA+NT+G  SQ M L V   P++          P+ V    G +V + 
Sbjct: 922  ----QDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLD 977

Query: 436  CEVFAYPSATISWFRDGQLLP--SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 493
            CE    P   ++W +D + +P  ++ Y  +     PS S L +      D G+Y CTA N
Sbjct: 978  CEAKGSPPPLVTWTKDSRPVPPITNRYGLL-----PSGS-LRLAQVQVGDSGHYECTASN 1031

Query: 494  RIGQESLEFIL-VQADTPSSP 513
              G  S  ++L VQ  T   P
Sbjct: 1032 PAGSASHRYVLGVQGRTSWQP 1052



 Score =  132 bits (331), Expect = 2e-30
 Identities = 171/715 (23%), Positives = 277/715 (38%), Gaps = 82/715 (11%)

Query: 31   ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
            +S GE+    C+V G+A   +++W   +   L  +  R++ +    +  +L I      D
Sbjct: 411  VSPGETAVLSCRVLGEAP-YNLTWVR-DWRVLPASTGRVAQL----ADLSLEISGIIPTD 464

Query: 91   AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
             G Y+CV +  +G  + A+V + + +        + Q F +G +  + C       P I 
Sbjct: 465  GGRYQCVASNANGV-TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHIS 523

Query: 151  WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINF--KDIQVIV 208
            W  + +   L++D R  V +   L I+G+   D G Y C+    A  E+    + + +  
Sbjct: 524  WSRESQ--ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ----ATNEVGTDQETVTLYY 577

Query: 209  NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDG-EQIEQEEDDEKYIFSD 267
              PP++ A   +V     +G+   LVC+A G P P + W + G E I   E         
Sbjct: 578  TDPPSVSAVNAVVLVA--VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-------GS 628

Query: 268  DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327
             S +L I    + D   Y C A N+ G+  A I L V   P++T +     +EL     L
Sbjct: 629  SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALL 688

Query: 328  TCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQY 387
             C A+G P P++TWR            +      ++   G            L  +S+  
Sbjct: 689  ACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG-----------VLFFESVAP 737

Query: 388  TDAGEYICTASNTIGQ-DSQSMYLEVQYAPK--LQGPVAVYTWEGNQVNITCEVFA-YPS 443
             D   Y+C A N  G+  +++  +   +AP         V   EG  V++ C V A  P 
Sbjct: 738  EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 797

Query: 444  ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 503
                W +DG+ LP  +  +I+     +   L +    +   G Y+C A N  G +  +  
Sbjct: 798  PERHWLKDGRPLPPGSRHSIR-----ADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVE 852

Query: 504  LVQADTPSSPSIDQVEPYSSTAQ-VQFDEPEATGGV--PILKYKAEWRAVGEEVWHSKWY 560
            LV       P I     +  T + V    P    GV  P + +  E  A+     H    
Sbjct: 853  LV---VQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH---- 905

Query: 561  DAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP---VQGEPSAP-- 615
                 S EG + I     +   A    A N  G           T+P   + G  +A   
Sbjct: 906  --YNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVP 963

Query: 616  -KLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIR----LPSGSDHVM 670
             ++  + GE+     V L  +  G  P    LV +   S    P       LPSGS  + 
Sbjct: 964  LQVTAKAGEE-----VTLDCEAKGSPP---PLVTWTKDSRPVPPITNRYGLLPSGSLRLA 1015

Query: 671  LKSLDWNAEYEVYVVAENQQGKSKAAHFV---FRTSAQPTAIPANGSPT--SGLS 720
               +  +  YE    A N  G +   + +    RTS QP ++P    P   SGLS
Sbjct: 1016 QVQVGDSGHYE--CTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLS 1068



 Score =  103 bits (257), Expect = 7e-22
 Identities = 87/376 (23%), Positives = 148/376 (39%), Gaps = 35/376 (9%)

Query: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA 195
           ++ C V S+LP  +  + +  +  L ++  F    N+  +I    K +EGTY C   +  
Sbjct: 328 LVSCSVHSALPFRL--QLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTA-VSR 384

Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
            G    K   V+ + PP +    N+   T + G++  L C   G     ++W +D   + 
Sbjct: 385 AGTGRAKAQIVVTDPPPQLVPAPNV---TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLP 441

Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
                   +       L I  +   D   Y C+A N  G   A++ L V   P+++   +
Sbjct: 442 ASTGRVAQL---ADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTS 498

Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHA 375
                   +V ++C ASG P P I+W   ++ +  + +              H+  +   
Sbjct: 499 SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI-------------HVDAQ--- 542

Query: 376 RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA-VYTWEGNQVNI 434
              +L ++ +   DAG Y C A+N +G D +++ L     P +    A V    G +  +
Sbjct: 543 --GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 600

Query: 435 TCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNR 494
            CE    P   + W+R G          I      S+  L +    E D G Y C AVN 
Sbjct: 601 VCEASGVPPPRVIWYRGG-------LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNE 653

Query: 495 IGQESLEFILVQADTP 510
           +G  S E  L     P
Sbjct: 654 LGDASAEIQLAVGHAP 669



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 69/264 (26%), Positives = 110/264 (41%), Gaps = 31/264 (11%)

Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
           +E++     +S   I +  K +E  Y C A ++AG   A   + V   P          +
Sbjct: 352 EERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV 411

Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS 379
              E   L+C   G+   ++TW    R +     AS  R  +   L             S
Sbjct: 412 SPGETAVLSCRVLGEAPYNLTWVRDWRVL----PASTGRVAQLADL-------------S 454

Query: 380 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-----WEGNQVNI 434
           L +  I  TD G Y C ASN  G    S++L V+ AP+    V+++T      +G +V +
Sbjct: 455 LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ----VSIHTSSQHFSQGVEVKV 510

Query: 435 TCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNR 494
           +C    YP+  ISW R+ Q L   +  ++    T     L +   +  D GNY+C A N 
Sbjct: 511 SCSASGYPTPHISWSRESQALQEDSRIHVDAQGT-----LIIQGVAPEDAGNYSCQATNE 565

Query: 495 IGQESLEFILVQADTPSSPSIDQV 518
           +G +     L   D PS  +++ V
Sbjct: 566 VGTDQETVTLYYTDPPSVSAVNAV 589



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 47/231 (20%), Positives = 81/231 (35%), Gaps = 12/231 (5%)

Query: 378 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITC 436
           SS  +      + G Y CTA +  G       + V   P    P    T   G    ++C
Sbjct: 362 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSC 421

Query: 437 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 496
            V       ++W RD ++LP+S     ++ +      LE++     D G Y C A N  G
Sbjct: 422 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS----LEISGIIPTDGGRYQCVASNANG 477

Query: 497 QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWH 556
                  L+  + P        + +S   +V+     +    P + +  E +A+ E+   
Sbjct: 478 VTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED--- 534

Query: 557 SKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 607
                      +G + I G+ PE        A N  G  + +    +   P
Sbjct: 535 ----SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 581


>gi|142976733 surface glycoprotein, Ig superfamily member [Homo
           sapiens]
          Length = 1264

 Score =  134 bits (336), Expect = 5e-31
 Identities = 168/721 (23%), Positives = 276/721 (38%), Gaps = 127/721 (17%)

Query: 52  ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGS--ESEAT 109
           ISW   NG+ L  N + + +        TLTI + N    G Y+C+     G+     AT
Sbjct: 59  ISWLH-NGKTLDGNLEHVKI-----HQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPAT 112

Query: 110 VNVKIFQKL--MFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVR-F 166
           V+V +        K+  T +E   G    I C V  S P   + ++K R   L+     +
Sbjct: 113 VSVAVLGDFGSSTKHVITAEEKSAG---FIGCRVPESNPKAEV-RYKIRGKWLEHSTENY 168

Query: 167 IVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI--QVIVNVPPTIQAR---QNIV 221
           ++L +  LQI  +   D+G+Y+C        ++  + I  +++V+ P +           
Sbjct: 169 LILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHS 228

Query: 222 NATANLGQS-VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKN 280
            A A L +S VTL C   G P P + W KDG+ I    +  +       S L    VD  
Sbjct: 229 QALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLY-----SHLATDSVDPA 283

Query: 281 DEAEYICIAENKAGE-QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSI 339
           D   Y C+A NK+G+ +  T  + V     I+       + L   V  TC+  G+P P+ 
Sbjct: 284 DSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNC 343

Query: 340 TWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASN 399
           TW  + + I    +              H+   +  ++S +T++     D G Y C A N
Sbjct: 344 TWFHNAQPIHPSAR--------------HLTAGNGLKISGVTVE-----DVGMYQCVADN 384

Query: 400 TIGQDSQSMYLEVQ----YAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQL 454
            IG    +  LE++    + P  +  PV+    +G+ V ++C     P   I W+    L
Sbjct: 385 GIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGL 444

Query: 455 LPS---------SNYSNIK------------IYNTPSASYLEVTPDSENDFGNYNCTAVN 493
           + S         S  S +             + +   AS L +   ++   G Y C A N
Sbjct: 445 ITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAAN 504

Query: 494 RIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEE 553
             G    E  L+            V P+ +                    KAE   + + 
Sbjct: 505 EHGTTQAEASLM------------VVPFETNT------------------KAETVTLPDA 534

Query: 554 VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPS 613
             +      ++ S  G+++   +K   +        N  G+  +  A    + P    P 
Sbjct: 535 AQNDD-RSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGI-SVPDAPIILSPPQTHTPD 592

Query: 614 APKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALS------SEWKPEIRLPSGSD 667
              L  + G+             DGG PI  Y V+YR L         W   +R+P   +
Sbjct: 593 TYNLVWRAGK-------------DGGLPINAYFVKYRKLDDGVGMLGSWH-TVRVPGSEN 638

Query: 668 HVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN---GSPTSGLSTGAI 724
            + L  L+ ++ YEV +VA +  G+ + A   FRTS + TA   N    SP  G+    +
Sbjct: 639 ELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPV 698

Query: 725 V 725
           V
Sbjct: 699 V 699



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 61/277 (22%), Positives = 110/277 (39%), Gaps = 43/277 (15%)

Query: 510 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 569
           P +P    +   S T+      P A GG PI  +K E++ +    W     D   + +  
Sbjct: 721 PEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLS- 779

Query: 570 IVTIVGLKPETTYAVRLAALNGKGLGEISAAS----------EFKTQPVQGEPSAPKLEG 619
            V +  L+P +TY  R+ A+N  G    S+AS           F ++P+ G P     E 
Sbjct: 780 -VEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITG-PHIAYTEA 837

Query: 620 QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRAL----SSEWKPEIRLPSGSDHVMLKSLD 675
            + +    +K   I   +  +PI+ + + YR       S++K ++   S   H M+  L 
Sbjct: 838 -VSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWH-MIGHLQ 895

Query: 676 WNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTG------------- 722
               Y++ +   N+ G+S+ ++ +   +       A+  P   LST              
Sbjct: 896 PETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPA 955

Query: 723 -----------AIVGILIVIFVLLLVVVDITCYFLNK 748
                       IVG ++ + VL+L+V    C + N+
Sbjct: 956 TSPARSSDMLYLIVGCVLGVMVLILMVFIAMCLWKNR 992


>gi|222352127 sidekick 2 [Homo sapiens]
          Length = 2172

 Score =  132 bits (333), Expect = 1e-30
 Identities = 170/718 (23%), Positives = 283/718 (39%), Gaps = 80/718 (11%)

Query: 31  ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
           +S GE+               ++WF  +G K+ P+  RI++   +    TL I +    D
Sbjct: 124 VSHGEAAVIRAPRIASFPQPQVTWFR-DGRKIPPSS-RIAITLEN----TLVILSTVAPD 177

Query: 91  AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA----------PTPQEFREGEDAVIVCD 140
           AG Y      +   +++ +  + +  + +   A          P       G   V +  
Sbjct: 178 AGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLEC 237

Query: 141 VVSSLPPT---IIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
           V ++ P     IIWK  G  V+L   +      N  L I     +D G Y CE  + +  
Sbjct: 238 VANARPLIKLHIIWKKDG--VLLSGGISD---HNRRLTIPNPTGSDAGYYECEAVLRSSS 292

Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
             +      +  + P    ++   + TA + + V + C A+G P P+++W KD   +E E
Sbjct: 293 VPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE 352

Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA-KPKITYVENQ 316
           +       +D   Q  I  +  +D   + C A N AGE   + +L V +  P IT     
Sbjct: 353 KLTRFRQRNDGGLQ--ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLD 410

Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHAR 376
           + +     V L CE SG P P+ITW+   R ++S    S   P       G         
Sbjct: 411 STVIDGMSVVLACETSGAPRPAITWQKGERILAS---GSVQLPRFTPLESG--------- 458

Query: 377 VSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW-EGNQVNIT 435
             SL +     +DAG Y C A+N+ G D  S  L V    ++  P    +  +G Q ++ 
Sbjct: 459 --SLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMV 516

Query: 436 CEVFAYPSATIS--WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 493
           C V   P  TI   W +DG  L + ++  I++    S   L ++     D G Y C  ++
Sbjct: 517 CGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGS---LHISQTWSGDIGTYTCRVIS 573

Query: 494 RIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEAT------GGVPILKY---- 543
             G +S    L     P +P      P ++ + V+      T      G  P+++Y    
Sbjct: 574 AGGNDSRSAHLRVRQLPHAPE----HPVATLSTVERRAINLTWTKPFDGNSPLIRYILEM 629

Query: 544 ---KAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 600
               A W  +   V      D K  S    VT+ GL P  +Y  RL A+N  G G+ S  
Sbjct: 630 SENNAPWTVLLASV------DPKATS----VTVKGLVPARSYQFRLCAVNDVGKGQFSKD 679

Query: 601 SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDG--GSPIRHYLVRY--RALSSEW 656
           +E  + P +   + P+     G    SI +      +      ++ Y++RY    L   +
Sbjct: 680 TERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGY 739

Query: 657 KPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQ--PTAIPAN 712
           + +    +  ++++L+ L     YE+ V A N  G    +  V   + Q  PT  P N
Sbjct: 740 QFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGN 797



 Score =  109 bits (273), Expect = 9e-24
 Identities = 156/652 (23%), Positives = 250/652 (38%), Gaps = 71/652 (10%)

Query: 91  AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTI 149
           AG Y+C+V    G+  +    V++     F+     Q    GE AVI    ++S P P +
Sbjct: 86  AGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQV 145

Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE-INFKDIQVIV 208
            W   GR +      R  +   N L I      D G Y  +      G+    + I + V
Sbjct: 146 TWFRDGRKI--PPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTV 203

Query: 209 N--------VPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPTMSWTKDGEQIEQEE 258
                    + PTI       +  A   + VTL C A   P  +  + W KDG  +    
Sbjct: 204 ENVGGPADPIAPTIIIPPKNTSVVAGTSE-VTLECVANARPLIKLHIIWKKDGVLLSGG- 261

Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI---HLKVFAKPK-ITYVE 314
                  SD + +LTI     +D   Y C A  ++    + +   +L V   P+ +   E
Sbjct: 262 ------ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPE 315

Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSH 374
                E+E+ V + C+A G P PSITW      +  E+   +     ++  DG       
Sbjct: 316 RHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRF-----RQRNDG------- 363

Query: 375 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-QYAPKL-QGPVAVYTWEGNQV 432
                L +  +   D G + C A N  G+   S YL V   AP + +GP+     +G  V
Sbjct: 364 ----GLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSV 419

Query: 433 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 492
            + CE    P   I+W +  ++L S +    +     S S L ++P   +D G Y C A 
Sbjct: 420 VLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLAT 478

Query: 493 NRIG-QESLEFILVQADT-----PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKY--K 544
           N  G  E+   ++V A T     P   S+ +    S    V  D P  T     ++Y  +
Sbjct: 479 NSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHD-PRVT-----IRYIWE 532

Query: 545 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 604
            +   +G E  H +    +  S+    T  G     TY  R+ +  G      S ++  +
Sbjct: 533 KDGATLGTES-HPRIRLDRNGSLHISQTWSG--DIGTYTCRVISAGGND----SRSAHLR 585

Query: 605 TQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI-RLP 663
            + +   P  P +      +  +I +   K  DG SP+  Y++     ++ W   +  + 
Sbjct: 586 VRQLPHAPEHP-VATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVD 644

Query: 664 SGSDHVMLKSLDWNAEYEVYVVAENQQGK---SKAAHFVFRTSAQPTAIPAN 712
             +  V +K L     Y+  + A N  GK   SK    V      PTA P N
Sbjct: 645 PKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQN 696



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 142/626 (22%), Positives = 233/626 (37%), Gaps = 110/626 (17%)

Query: 120 FKNAPT-PQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVI-LKKDVRFIVLSNNYLQIR 177
           FK  P   Q   EG   V+ C    S P    W H  R++     + R+++ S       
Sbjct: 28  FKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITS------- 80

Query: 178 GIKKTDEGTYRC-----EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVT 232
            + +T  G YRC      G +L R        Q  V V       +   + + + G++  
Sbjct: 81  -LDRTHAGFYRCIVRNRMGALLQR--------QTEVQVAYMGSFEEGEKHQSVSHGEAAV 131

Query: 233 LVCD-AEGFPEPTMSWTKDGEQIEQEE------DDEKYIFS---DDSSQLTIKKV-DKND 281
           +       FP+P ++W +DG +I          ++   I S    D+ +  ++ V DKN 
Sbjct: 132 IRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNG 191

Query: 282 E---AEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPS 338
           +   ++ I +     G     I   +   PK T V   T+     +VTL C A+  P+  
Sbjct: 192 DNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTS-----EVTLECVANARPLIK 246

Query: 339 --ITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICT 396
             I W+     +S                     +  H R   LT+ +   +DAG Y C 
Sbjct: 247 LHIIWKKDGVLLSGG-------------------ISDHNR--RLTIPNPTGSDAGYYECE 285

Query: 397 A---SNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWEGNQ-VNITCEVFAYPSATISWFRD 451
           A   S+++    +  YL V   P+ ++ P    T E  + V+I C+    P  +I+W++D
Sbjct: 286 AVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKD 345

Query: 452 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 511
             ++     +  +  N        + PD   D G + C A N  G+      L  A T  
Sbjct: 346 AAVVEVEKLTRFRQRNDGGLQISGLVPD---DTGMFQCFARNAAGEVQTSTYL--AVTSI 400

Query: 512 SPSIDQVEPYSSTAQVQFDEPEA--TGGVP---ILKYKAEWRAVGEEVWHSKWYDAKEAS 566
           +P+I +  P  ST         A  T G P   I   K E       V   ++   +  S
Sbjct: 401 APNITR-GPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGS 459

Query: 567 MEGIVTIVGLKPETTYAVRLAALNGKGLGEISA-----ASEFKTQPVQGEPSAPKLEGQM 621
           +  +++   +    TY     A N +G+ E SA     A    T+P Q +      +  M
Sbjct: 460 L--LISPTHISDAGTYT--CLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASM 515

Query: 622 ---GEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLP-SGSDHVMLKSLDWN 677
                    + +  I + DG +           L +E  P IRL  +GS H+   S  W+
Sbjct: 516 VCGVTHDPRVTIRYIWEKDGAT-----------LGTESHPRIRLDRNGSLHI---SQTWS 561

Query: 678 AEYEVYVVAENQQG--KSKAAHFVFR 701
            +   Y       G   S++AH   R
Sbjct: 562 GDIGTYTCRVISAGGNDSRSAHLRVR 587



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 43/161 (26%), Positives = 66/161 (40%), Gaps = 8/161 (4%)

Query: 572  TIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGED--GNSIK 629
            T  GLKPE+ Y  R+ A   KG GE + A    T+  +  P  P       ED    S+ 
Sbjct: 1361 TATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEK-RDRPQPPSRPMVQQEDVRARSVL 1419

Query: 630  VNLIKQDDGGSPIRHYLVRYRAL-SSEWK-PEIRLPSGSDHVMLKSLDWNAEYEVYVVAE 687
            ++     DG SP+R+Y ++ R L S  W      +   +   ++  L     Y+  V A 
Sbjct: 1420 LSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKAT 1479

Query: 688  NQQGK---SKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIV 725
            N  G    S+ +  +    A P   P   S T   +T  ++
Sbjct: 1480 NDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLI 1520



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 25/93 (26%), Positives = 40/93 (43%), Gaps = 1/93 (1%)

Query: 510  PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 569
            P  P +  +  YSS   + +   +   G PI +Y  E R   E +W     D  +     
Sbjct: 1825 PGPPGVPIIVRYSSAIAIHWSSGDPGKG-PITRYVIEARPSDEGLWDILIKDIPKEVSSY 1883

Query: 570  IVTIVGLKPETTYAVRLAALNGKGLGEISAASE 602
              ++  LKP  +Y  R+ A+N  G G  S+ S+
Sbjct: 1884 TFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQ 1916



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 33/129 (25%), Positives = 54/129 (41%), Gaps = 5/129 (3%)

Query: 519  EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKP 578
            E   ++ +V + EP    G+ +  Y+  W            Y     ++E  VT  GL  
Sbjct: 905  EILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVTHY-LPNVTLEYRVT--GLTA 960

Query: 579  ETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDG 638
             TTY + +AA+  KG G++SA++     P +  P  P   G       S+ +      DG
Sbjct: 961  LTTYTIEVAAMTSKGQGQVSASTISSGVPPE-LPGPPTNLGISNIGPRSVTLQFRPGYDG 1019

Query: 639  GSPIRHYLV 647
             + I  +LV
Sbjct: 1020 KTSISRWLV 1028


>gi|119220552 sidekick 1 [Homo sapiens]
          Length = 2213

 Score =  129 bits (323), Expect = 2e-29
 Identities = 167/696 (23%), Positives = 267/696 (38%), Gaps = 78/696 (11%)

Query: 52  ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
           ++WF   G K+ P+  RI++   +     L I      DAG Y      E   E++ +  
Sbjct: 223 VTWFR-EGHKIIPSN-RIAITLENQ----LVILATTTSDAGAYYVQAVNEKNGENKTSPF 276

Query: 112 VKIFQKLMFKNAPTPQEFRE------GEDAVIV------CDVVSSLPP----TIIWKHKG 155
           + +    + ++  TP+          G  +V+        + ++S  P    ++ WK  G
Sbjct: 277 IHLS---IARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNG 333

Query: 156 RDVI--LKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPT 213
             +   L    R + +SN           D G Y CE  +        +    +  + P 
Sbjct: 334 VRITSGLHSFGRRLTISNP-------TSADTGPYVCEAALPGSAFEPARATAFLFIIEPP 386

Query: 214 IQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLT 273
               +     +A + ++V + C A G P PT+ W KD   I + ++    + +  S  L 
Sbjct: 387 YFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLA--SGGLR 444

Query: 274 IKKVDKNDEAEYICIAENKAGEQDATIHLKVF-AKPKITYVENQTAMELEEQVTLTCEAS 332
           I+K+   D   + C A N+ GE     +L V    P  T     T +       L CE S
Sbjct: 445 IQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVS 504

Query: 333 GDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGE 392
           G P P+ITW+     ++S              +   M++ S      L +  +   DAG 
Sbjct: 505 GAPKPAITWKRENHILASGSVR----------IPRFMLLES----GGLQIAPVFIQDAGN 550

Query: 393 YICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW-EGNQVNITCEVFAYPSATIS--WF 449
           Y C A+NT G  + S  L V     +  P   +   +G    + C     P  ++   W 
Sbjct: 551 YTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWK 610

Query: 450 RDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADT 509
           +D   L  S+ S I +    S   L ++     D G+Y+C  V+  G +S    L   + 
Sbjct: 611 KDNVALTPSSTSRIVVEKDGS---LLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIEL 667

Query: 510 PSSPSIDQVEPYSSTAQV-------QFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDA 562
           P SP    V P SS +          FD     G  PIL Y  E  +     W     + 
Sbjct: 668 PHSPQNLLVSPNSSHSHAVVLSWVRPFD-----GNSPILYYIVEL-SENNSPWKVHLSNV 721

Query: 563 KEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMG 622
               M G VT+ GL P  TY  R+ A+N  G G+ SA +     P +   + PK     G
Sbjct: 722 GP-EMTG-VTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASG 779

Query: 623 EDGNSIKVNL--IKQDDGGSPIRHYLVRYR--ALSSEWKPEIRLPSGSDHVMLKSLDWNA 678
               SI V      + +    +R Y++RYR   L  E++         ++ ++  L    
Sbjct: 780 RTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWT 839

Query: 679 EYEVYVVAENQQGKSKAAHFVFRTSAQ--PTAIPAN 712
           +YE+ V A N  G    +  V   + Q  PTA P N
Sbjct: 840 QYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQN 875



 Score =  108 bits (270), Expect = 2e-23
 Identities = 150/666 (22%), Positives = 254/666 (38%), Gaps = 72/666 (10%)

Query: 90  DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PT 148
           DAG Y+CVV    G+  +    V++     F +    +   +G  A++    ++S P P 
Sbjct: 163 DAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQ 222

Query: 149 IIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN-------- 200
           + W  +G  +I     R  +   N L I     +D G Y  +      GE          
Sbjct: 223 VTWFREGHKIIPSN--RIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLS 280

Query: 201 -FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPTMSWTKDGEQIEQE 257
             +D+     + PTI       +  A   ++ TL C A   P  + +++W ++G +I   
Sbjct: 281 IARDVGTPETMAPTIVVPPGNRSVVAGSSET-TLECIASARPVEDLSVTWKRNGVRITSG 339

Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQD---ATIHLKVFAKPKIT-YV 313
                        +LTI      D   Y+C A       +   AT  L +   P  T   
Sbjct: 340 -------LHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEP 392

Query: 314 ENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRS 373
           E++ + E+EE V + C+A G P+P++ W     +IS  +      P  +    G      
Sbjct: 393 ESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQ-----NPRYKVLASG------ 441

Query: 374 HARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-QYAPKL-QGPVAVYTWEGNQ 431
                 L ++ ++  D+G + C ASN  G+     YL+V   AP   Q PV     +G  
Sbjct: 442 -----GLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMT 496

Query: 432 VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 491
             + CEV   P   I+W R+  +L S +   I  +    +  L++ P    D GNY C A
Sbjct: 497 AILRCEVSGAPKPAITWKRENHILASGSV-RIPRFMLLESGGLQIAPVFIQDAGNYTCYA 555

Query: 492 VNRIGQESLEFILVQADTPS--SPSIDQVEPYSSTAQVQ---FDEPEATGGVPILKYKAE 546
            N  G  +    L   +  S   P  D V    +TA +      +P  +     L+Y   
Sbjct: 556 ANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVS-----LRY--- 607

Query: 547 WRAVGEEVWHSKWYDAKEASMEGIVTIV--GLKPETTYAVRLAALNGKGLGEISAASEFK 604
                  VW         +S   IV      L    T++  +   + + + E    S   
Sbjct: 608 -------VWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMA 660

Query: 605 TQPVQGEPSAPK--LEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI-R 661
              V   P +P+  L        +++ ++ ++  DG SPI +Y+V     +S WK  +  
Sbjct: 661 RLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSN 720

Query: 662 LPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFR--TSAQPTAIPANGSPTSGL 719
           +      V +  L     Y+  V A N+ G+ + +    R     +P + P      SG 
Sbjct: 721 VGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGR 780

Query: 720 STGAIV 725
           +  +I+
Sbjct: 781 TNQSIM 786



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 48/202 (23%), Positives = 83/202 (41%), Gaps = 11/202 (5%)

Query: 523  STAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTY 582
            ++ ++ +  PE   G+ IL Y+  +R            +      +   T   L PE+ Y
Sbjct: 1392 TSVRIVWQPPEEPNGI-ILGYQIAYRLASSSPHTFTTVEVGATVRQ--FTATDLAPESAY 1448

Query: 583  AVRLAALNGKGLGEISAASEFKTQPVQGEPSAPK--LEGQMGEDGNSIKVNLIKQDDGGS 640
              RL+A   +G GE   A+   T+  +  P+ P+  L  Q      S+++  +   DG S
Sbjct: 1449 IFRLSAKTRQGWGEPLEATVITTEKRE-RPAPPRELLVPQAEVTARSLRLQWVPGSDGAS 1507

Query: 641  PIRHYLVRYRAL-SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHF 698
            PIR++ ++ R L   EW+     +   +   ++  L     Y++ + A N  G S    F
Sbjct: 1508 PIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDS---DF 1564

Query: 699  VFRTSAQPTAIPANGSPTSGLS 720
               T A  T     G P   +S
Sbjct: 1565 SSETEAVTTLQDVPGEPPGSVS 1586



 Score = 38.9 bits (89), Expect = 0.021
 Identities = 60/284 (21%), Positives = 110/284 (38%), Gaps = 58/284 (20%)

Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
           G  + L C AEG       W +D  ++     + KYI         I  + K D   Y C
Sbjct: 119 GNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYI---------IPSLQKLDAGFYRC 169

Query: 288 IAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347
           +  N+ G   A +  K  ++ ++ Y+   + M+ +++ T++             R +  N
Sbjct: 170 VVRNRMG---ALLQRK--SEVQVAYM--GSFMDTDQRKTVS-----------QGRAAILN 211

Query: 348 ISSEEKASWTRPEKQETLDGHMVVRSH----ARVSSLTLKSIQYTDAGEYICTASN-TIG 402
           +      S+ RP+     +GH ++ S+       + L + +   +DAG Y   A N   G
Sbjct: 212 LL--PITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNG 269

Query: 403 QDSQSMYLEVQYA-----PKLQGPVAVYTWEGN--------QVNITCEVFAYP--SATIS 447
           ++  S ++ +  A     P+   P  V    GN        +  + C   A P    +++
Sbjct: 270 ENKTSPFIHLSIARDVGTPETMAPTIVVP-PGNRSVVAGSSETTLECIASARPVEDLSVT 328

Query: 448 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 491
           W R+G  + S  +S            L ++  +  D G Y C A
Sbjct: 329 WKRNGVRITSGLHS--------FGRRLTISNPTSADTGPYVCEA 364



 Score = 33.5 bits (75), Expect = 0.86
 Identities = 26/93 (27%), Positives = 40/93 (43%), Gaps = 1/93 (1%)

Query: 509  TPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME 568
            +P SP    V   +S   +Q+ E  + G  P   Y  E R   E +W     D   ++  
Sbjct: 1902 SPGSPRDVLVTKSASELTLQWTEGHS-GDTPTTGYVIEARPSDEGLWDMFVKDIPRSATS 1960

Query: 569  GIVTIVGLKPETTYAVRLAALNGKGLGEISAAS 601
              +++  L+   TY  R+ A+N  G GE S  S
Sbjct: 1961 YTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPS 1993


>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
            sapiens]
          Length = 2113

 Score =  127 bits (318), Expect = 6e-29
 Identities = 163/729 (22%), Positives = 287/729 (39%), Gaps = 64/729 (8%)

Query: 27   SQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSS--STLTIY 84
            S+  ++ GE    +C   G A    ++W   +   +     R +     D +  S + + 
Sbjct: 475  SEKVVNPGEQFSLMCAAKG-APPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVT 533

Query: 85   NANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFRE-----GEDAVIV 138
               I D G+Y+C      GS E +A +NV+          P+ +  R      G D +I 
Sbjct: 534  GPQIRDGGVYRCTARNLVGSAEYQARINVR--------GPPSIRAMRNITAVAGRDTLIN 585

Query: 139  CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK-TDEGTYRCEGRILARG 197
            C V+     +I W      ++L  + R +V  N  L++  ++K  DEG Y C   I  + 
Sbjct: 586  CRVIGYPYYSIKWYKDA--LLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL 643

Query: 198  EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPT-MSWTKDGEQIEQ 256
             I+ + + V V VPP IQ  +      A++GQ + + C       P  ++W KDG+ I  
Sbjct: 644  SIS-QSVHVAVKVPPLIQPFEF---PPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIIS 699

Query: 257  EE----DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITY 312
                  + ++++     S L I  V       Y CIA N A        L V   P+   
Sbjct: 700  GSGVTIESKEFM-----SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVV 754

Query: 313  VENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVR 372
              N       +   L C   G P P + W+ +  + + ++            L G + + 
Sbjct: 755  QPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQ-------YHPVPLTGRIQIL 807

Query: 373  SHARVSSLTLKSIQYTDAGEYICTASNTIGQD-SQSMYLEVQYAPKLQG-PVAVYTWEGN 430
             +   SSL ++ +   D G Y+C ASN +G D S+SM+L V+    +   P      +G+
Sbjct: 808  PN---SSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGH 864

Query: 431  QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPS----ASYLEVTPDSENDFGN 486
               + C         I W +   ++         I    +     S L++ P    D   
Sbjct: 865  AKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVF 924

Query: 487  YNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAE 546
            ++C A+N  G++     L   + P  P ++  E  + +  +++ +    G   I  +  E
Sbjct: 925  FSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQ-RFDGNSIITGFDIE 983

Query: 547  WRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQ 606
            ++   +  W  K      +       IV L P + Y++R+ + N  G  E S      T+
Sbjct: 984  YKNKSDS-WDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTE 1042

Query: 607  PVQGEPSAPKLEGQMGE-DGNSIKV--NLIKQDDGGSPIRHYLVRYRALSSEWK-----P 658
              +  P  P ++  +      SI+V     K++     IR Y + YR  S          
Sbjct: 1043 --EAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIV 1100

Query: 659  EIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQ--PTAIPANGSPT 716
            E++    S+   L +L   A+Y V V A N+ G   ++  +  T+ +  P+  P N    
Sbjct: 1101 EMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRAL 1160

Query: 717  SGLSTGAIV 725
            S  S  A++
Sbjct: 1161 SITSDVAVI 1169



 Score =  103 bits (256), Expect = 9e-22
 Identities = 124/519 (23%), Positives = 200/519 (38%), Gaps = 64/519 (12%)

Query: 66  QQRISVV-WNDDSSSTLT-----------IYNANI---DDAGIYKCVVTGEDGSESEATV 110
           Q+ +SVV W  D+ S +            +Y +++   D    Y+C+   +   E+  + 
Sbjct: 213 QEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSN 272

Query: 111 NVKIFQKLMFKNAPT------PQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDV 164
             ++      ++ PT       QE   G    + C       P I W   GR   L  D 
Sbjct: 273 GARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP--LPADS 330

Query: 165 RFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILARGEINFKDIQVIVNVPPTIQARQN 219
           R+       L I  ++  D GTY CE     G   A G +   D   +   P  ++    
Sbjct: 331 RWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKT--- 386

Query: 220 IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDK 279
                  +G +V L C   G PE T+ W ++ E +  +E       S+++  L I    K
Sbjct: 387 ------GIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNET--LLITSAQK 438

Query: 280 NDEAEYICIAENKAGE-QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPS 338
           +    Y C A  KA   QD  I       P+I    ++  +   EQ +L C A G P P+
Sbjct: 439 SHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPT 498

Query: 339 ITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 398
           +TW      I  +      R  +    DG         +S + +   Q  D G Y CTA 
Sbjct: 499 VTWALDDEPIVRDGSH---RTNQYTMSDG-------TTISHMNVTGPQIRDGGVYRCTAR 548

Query: 399 NTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSS 458
           N +G       + V+  P ++    +    G    I C V  YP  +I W++D  LLP  
Sbjct: 549 NLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLP-D 607

Query: 459 NYSNIKIYNTPSASYLEVTPDSEN-DFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQ 517
           N+  +   N      L++T   +  D G Y C+ + +      + + V    P  P I  
Sbjct: 608 NHRQVVFEN----GTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVP--PLIQP 661

Query: 518 VE-PYSSTAQVQFDE-PEATGGVPILKYKAEWRAVGEEV 554
            E P +S  Q+ +     ++G +PI   +  WR  G+ +
Sbjct: 662 FEFPPASIGQLLYIPCVVSSGDMPI---RITWRKDGQVI 697



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 158/681 (23%), Positives = 254/681 (37%), Gaps = 86/681 (12%)

Query: 90   DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE-----GEDAVIVCDVVSS 144
            D G Y C V  +       +V+V +      K  P  Q F       G+   I C V S 
Sbjct: 629  DEGEYLCSVLIQPQLSISQSVHVAV------KVPPLIQPFEFPPASIGQLLYIPCVVSSG 682

Query: 145  -LPPTIIWKHKGRDVILKKDVRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGEIN 200
             +P  I W+  G+ +I    V   + S  +   LQI  +     G Y C     A     
Sbjct: 683  DMPIRITWRKDGQVIISGSGVT--IESKEFMSSLQISSVSLKHNGNYTCIASNAAATVS- 739

Query: 201  FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
             ++ Q+IV VPP    + N  N     G++  L C  +G+P P + W    +  +   + 
Sbjct: 740  -RERQLIVRVPPRFVVQPN--NQDGIYGKAGVLNCSVDGYPPPKVMW----KHAKGSGNP 792

Query: 261  EKY--------IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQ-DATIHLKVFAKPKIT 311
            ++Y        I    +S L I+ V + D   Y+C A N  G     ++ L V     IT
Sbjct: 793  QQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMIT 852

Query: 312  YVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVV 371
               N T         L C A G+    I W      I  +    +    K    +G  VV
Sbjct: 853  SHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKD---NGDEVV 909

Query: 372  RSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP----------KLQGP 421
                  S+L LK     D+  + C A N+ G+D   + L VQ  P          K +  
Sbjct: 910  ------STLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSM 963

Query: 422  VAVYT--WEGNQVNITCEVFAYPSATISW-FRDG--QLLPSSNYSNIKIYNTPSASYLEV 476
               +T  ++GN + IT     Y + + SW F+     + P+ N +NI          +++
Sbjct: 964  NLRWTQRFDGNSI-ITGFDIEYKNKSDSWDFKQSTRNISPTINQANI----------VDL 1012

Query: 477  TPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSID-QVEPYSSTA-QVQFDEP-- 532
             P S      Y+   + R        I  +   P  P +D  ++P +S + QV +  P  
Sbjct: 1013 HPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKK 1072

Query: 533  EATGGVPILKYKAEWR--AVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 590
            E   GV I  Y+  +R  + G    +S   + K      + T+  LK    Y V + A N
Sbjct: 1073 ELQNGV-IRGYQIGYRENSPGSNGQYSI-VEMKATGDSEVYTLDNLKKFAQYGVVVQAFN 1130

Query: 591  GKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYR 650
              G G  S  SE     ++  PS P    +     + + V +   +   S +   L  YR
Sbjct: 1131 RAGTGPSS--SEINATTLEDVPSQPPENVRALSITSDVAV-ISWSEPPRSTLNGVLKGYR 1187

Query: 651  AL------SSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSA 704
             +        EW     + +  + V L+ ++    Y V V+A  Q G    +  ++  + 
Sbjct: 1188 VIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTK 1247

Query: 705  QPTAIPANGSPTSGLSTGAIV 725
            +    P  G      S  ++V
Sbjct: 1248 EDVPGPPAGIKAVPSSASSVV 1268



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 81/329 (24%), Positives = 134/329 (40%), Gaps = 65/329 (19%)

Query: 323  EQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTL 382
            + V L C + GDP P++ W        SE+ A         ++DGH ++ ++    +L L
Sbjct: 1365 KDVRLPCNSVGDPAPAVKWTK-----DSEDSAI------PVSMDGHRLIHTN---GTLLL 1410

Query: 383  KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP--------KLQGPVAVYTW---EGNQ 431
            ++++  D+G Y CTA+NT G D+  + L VQ  P        K        TW   +   
Sbjct: 1411 RAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGG 1470

Query: 432  VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 491
             +I   V  Y       ++D  +  SS+  + K+ +    ++ +V   ++N  G+     
Sbjct: 1471 SSIRGFVLQYSVDNSEEWKD--VFISSSERSFKLDSLKCGTWYKVKLAAKNSVGS----- 1523

Query: 492  VNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEAT-----------GGVPI 540
              RI +      +++A T         EP  S  Q  F    +T           GG PI
Sbjct: 1524 -GRISE------IIEAKTHGR------EPSFSKDQHLFTHINSTHARLNLQGWNNGGCPI 1570

Query: 541  LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 600
                 E+R  G   W         A+  G V +  L+  T Y +R+ A N  G G  +A 
Sbjct: 1571 TAIVLEYRPKGTWAW-----QGLRANSSGEVFLTELREATWYELRMRACNSAGCGNETA- 1624

Query: 601  SEFKTQPVQGEPSAPKLEGQMGEDGNSIK 629
             +F T    G  + P ++   GE G+ +K
Sbjct: 1625 -QFATLDYDGS-TIPPIKSAQGE-GDDVK 1650



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 86/354 (24%), Positives = 137/354 (38%), Gaps = 31/354 (8%)

Query: 402  GQDSQSMYLEVQYAPKLQGPVAVYTWEGN-------QVNITCEVFAYPSATISWFRDGQ- 453
            G  S+ + +E    P  + P  + ++ G         V + C     P+  + W +D + 
Sbjct: 1334 GNSSEKVTIE----PAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSED 1389

Query: 454  -LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSS 512
              +P S   +  I+   +     V  +   D G Y CTA N  G +++   L+    P  
Sbjct: 1390 SAIPVSMDGHRLIHTNGTLLLRAVKAE---DSGYYTCTATNTGGFDTIIVNLLVQVPPDQ 1446

Query: 513  PSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVT 572
            P +   +  +S+  + +  P   GG  I  +  ++     E W   +  + E S +    
Sbjct: 1447 PRLTVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFK---- 1501

Query: 573  IVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGE-DGNSIKVN 631
            +  LK  T Y V+LAA N  G G IS   E KT     EPS  K +      +    ++N
Sbjct: 1502 LDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTH--GREPSFSKDQHLFTHINSTHARLN 1559

Query: 632  LIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 691
            L   ++GG PI   ++ YR     W  +    + S  V L  L     YE+ + A N  G
Sbjct: 1560 LQGWNNGGCPITAIVLEYRP-KGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAG 1618

Query: 692  -KSKAAHFVFRTSAQPTAIP-----ANGSPTSGLSTGAIVGILIVIFVLLLVVV 739
              ++ A F        T  P       G     L T     IL  + V LL +V
Sbjct: 1619 CGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFIV 1672



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 70/311 (22%), Positives = 119/311 (38%), Gaps = 49/311 (15%)

Query: 219 NIVNATANLGQSVTLVCDAEGFPEPTMSW-TKDGEQIEQEEDDEKYIFSDDSSQLTIKKV 277
           ++   T +    V + C A G P   + W    G+ I  +    +++ ++ + QL     
Sbjct: 91  SLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDI-YDVPHIRHVHANGTLQLYPFSP 149

Query: 278 DKND----EAEYICIAENKAGE-QDATIHLK-VFAKPKITYVENQTAMELEEQV--TLTC 329
              +    + +Y C AEN AG+ +   I +K VF +P    VE+Q +M     V   L  
Sbjct: 150 SAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIP 209

Query: 330 EASGDPIPSITWRTSTRNISSEEKASWT--------RPEKQETLDGHMVVRSHARVSSLT 381
            +  + +  ++W   T +I  E +   T          +K++ L  +  +  H + S  T
Sbjct: 210 SSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKH-KYSGET 268

Query: 382 LKS----IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCE 437
            +S    +  TD  E I T                     L G  +   W G+ V + C 
Sbjct: 269 RQSNGARLSVTDPAESIPTI--------------------LDGFHSQEVWAGHTVELPCT 308

Query: 438 VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 497
              YP   I W +DG+ LP+ +    +I      + L ++     D G Y C   N  G 
Sbjct: 309 ASGYPIPAIRWLKDGRPLPADSRWTKRI------TGLTISDLRTEDSGTYICEVTNTFGS 362

Query: 498 ESLEFILVQAD 508
                IL+  D
Sbjct: 363 AEATGILMVID 373



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 30/107 (28%), Positives = 46/107 (42%), Gaps = 8/107 (7%)

Query: 208  VNVPPTIQARQNIVN----ATANLGQSVTLVCDAEGFPEPTMSWTKDGEQ--IEQEEDDE 261
            V + P  +A   I++     T    + V L C++ G P P + WTKD E   I    D  
Sbjct: 1340 VTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH 1399

Query: 262  KYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
            + I ++ +  L ++ V   D   Y C A N  G     ++L V   P
Sbjct: 1400 RLIHTNGT--LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP 1444



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 75/364 (20%), Positives = 134/364 (36%), Gaps = 52/364 (14%)

Query: 356  WTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYA 415
            W   +   T    + +R   + ++ +++ + YT AG+ +           +S  L +Q  
Sbjct: 1199 WGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGV-----------RSSVLYIQTK 1247

Query: 416  PKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFR----DGQLLPSSNYSNIKIYNTPSA 471
              + GP A          I     +  S  +SW      +G +   + + +      P+ 
Sbjct: 1248 EDVPGPPA---------GIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAP 1298

Query: 472  SYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQV--EPYSSTAQVQF 529
            S  E +P+       Y    +NR GQ+ L ++          S ++V  EP +  A  + 
Sbjct: 1299 SEYETSPEQLF----YRIAHLNR-GQQYLLWVAAVTSAGRGNSSEKVTIEP-AGKAPAKI 1352

Query: 530  DEPEATGGVPILK-YKAEWRAVGEEVWHSKWYDAKEASM-------------EGIVTIVG 575
                 T   P +K  +    +VG+     KW    E S               G + +  
Sbjct: 1353 ISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRA 1412

Query: 576  LKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQ 635
            +K E +      A N  G   I          VQ  P  P+L        +SI +  I  
Sbjct: 1413 VKAEDSGYYTCTATNTGGFDTIIV-----NLLVQVPPDQPRLTVSK-TSASSITLTWIPG 1466

Query: 636  DDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 695
            D+GGS IR ++++Y   +SE   ++ + S      L SL     Y+V + A+N  G  + 
Sbjct: 1467 DNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRI 1526

Query: 696  AHFV 699
            +  +
Sbjct: 1527 SEII 1530



 Score = 34.3 bits (77), Expect = 0.51
 Identities = 26/103 (25%), Positives = 45/103 (43%), Gaps = 8/103 (7%)

Query: 133  EDAVIVCDVVSSLPPTIIWKHKGRD--VILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190
            +D  + C+ V    P + W     D  + +  D   ++ +N  L +R +K  D G Y C 
Sbjct: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424

Query: 191  GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTL 233
                  G  +   + ++V VPP  Q R  +   +A+   S+TL
Sbjct: 1425 A--TNTGGFDTIIVNLLVQVPPD-QPRLTVSKTSAS---SITL 1461


>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
           sapiens]
          Length = 1248

 Score =  126 bits (317), Expect = 8e-29
 Identities = 162/706 (22%), Positives = 271/706 (38%), Gaps = 104/706 (14%)

Query: 52  ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
           I W  P+G            V   + + TL +     +D G Y+C+     GS   A   
Sbjct: 269 IKWLRPSGPMPADR------VTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYY- 321

Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVI-LKKDVRFIVLS 170
           V +     + + P    +  GE A + C V     P + W+  G  V  L KD ++ +  
Sbjct: 322 VTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI-Q 380

Query: 171 NNYLQIRGIKKTDEGTYRCEGR-----ILARGEINFKDIQVIVNVPPTIQARQNIVNATA 225
              L +  ++ +D    +CE R     +LA   I       +V +P  I    N      
Sbjct: 381 RGALILSNVQPSDTMVTQCEARNRHGLLLANAYI------YVVQLPAKILTADNQTYMAV 434

Query: 226 NLGQSVTLVCDAEGFPEPTMSWT-KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
             G +  L+C A G P P++ W  +DG  + Q+E      F   +  L I+ +  ND   
Sbjct: 435 Q-GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDER----FFPYANGTLGIRDLQANDTGR 489

Query: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPI--PSITWR 342
           Y C+A N         +LKV    +IT     T  +   +VT TC+AS DP   PSITWR
Sbjct: 490 YFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWR 549

Query: 343 TSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 402
              R++     +     +K    DG +V+            S+ Y+D G Y C AS  + 
Sbjct: 550 GDGRDLQELGDS-----DKYFIEDGRLVIH-----------SLDYSDQGNYSCVASTELD 593

Query: 403 QDSQSMYLEVQYAPKLQGPVA------VYTWEGNQVNITCEVFAYPSATIS----WFRDG 452
                  L V  +P   GPV       ++    +QV ++       +A I      F D 
Sbjct: 594 VVESRAQLLVVGSP---GPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDK 650

Query: 453 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSS 512
           ++ P   YS  K+    +++ L+++P     F     TA+N+ G      +     TP  
Sbjct: 651 EMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTF---RVTAINKYGPGEPSPVSETVVTP-- 705

Query: 513 PSIDQVEPYSSTAQVQFDEPEATGGV-------------PILKYKAEWRAVGEEVWHSKW 559
               +  P  +   V+ +  E T  V             P ++Y+ +WR  G       W
Sbjct: 706 ----EAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGT---RGPW 758

Query: 560 YDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLG---EISAASEFKTQPVQGEPSAPK 616
            +  +   +  + +        Y +++ A+N +G G   +++     +  P     + P+
Sbjct: 759 QE--QIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYP----QAIPE 812

Query: 617 LEG--QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSE--------WKPEIRLPSGS 666
           LEG   +      +K   +        +R Y V Y    S+         K  + +P+ +
Sbjct: 813 LEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANT 872

Query: 667 DHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 712
             V+L  L   + Y + V A N +G   A+ F F T   P  +P +
Sbjct: 873 TSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFST---PEGVPGH 915



 Score =  105 bits (261), Expect = 2e-22
 Identities = 128/552 (23%), Positives = 205/552 (37%), Gaps = 86/552 (15%)

Query: 41  CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDA----GIYKC 96
           C+ +G   +    W + +G    P ++    V+    S + TI   N + A    GIY+C
Sbjct: 52  CEASGKP-EVQFRW-TRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRC 109

Query: 97  VVTGEDGSESEATVNVKIFQKLMFKNAPT-------PQEFREGEDAVIVCDVVSSLPPTI 149
             + + G+     +      +LM + AP        P E  EGE  V+ C+   S  P  
Sbjct: 110 FASNKLGTAMSHEI------RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLR 163

Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGT-YRCEGRILARGEINFK---DIQ 205
           I+    + + +K+D R  +  N  L    +  +D  + Y C         I  K   D++
Sbjct: 164 IYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLR 223

Query: 206 V------IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
           V      I   P  +    +  +  A  GQ + L C AEGFP PT+ W +    +     
Sbjct: 224 VKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPA--- 280

Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
            ++  + + +  L + KV + D+ EY C+AEN  G      ++ V A P   +       
Sbjct: 281 -DRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLY 339

Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS 379
              E   L C+  G P P +TWR +   I  EE A   + +K     G           +
Sbjct: 340 GPGETARLDCQVQGRPQPEVTWRIN--GIPVEELA---KDQKYRIQRG-----------A 383

Query: 380 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK--LQGPVAVY-TWEGNQVNITC 436
           L L ++Q +D     C A N  G    + Y+ V   P   L      Y   +G+   + C
Sbjct: 384 LILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLC 443

Query: 437 EVFAYPSATISW--------FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
           + F  P  ++ W         +D +  P +N              L +     ND G Y 
Sbjct: 444 KAFGAPVPSVQWLDEDGTTVLQDERFFPYAN------------GTLGIRDLQANDTGRYF 491

Query: 489 CTAVNRIGQESLEFILVQADT------PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 542
           C A N     ++   L   D       P S    +    + T Q  FD        P L+
Sbjct: 492 CLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFD--------PSLQ 543

Query: 543 YKAEWRAVGEEV 554
               WR  G ++
Sbjct: 544 PSITWRGDGRDL 555



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 123/516 (23%), Positives = 198/516 (38%), Gaps = 52/516 (10%)

Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190
           +G  A ++C    +  P++ W  +    +L+ D RF   +N  L IR ++  D G Y C 
Sbjct: 435 QGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQ-DERFFPYANGTLGIRDLQANDTGRYFC- 492

Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPTMSWT 248
              LA  + N   I   + V    Q  Q   +     G  VT  C A   P  +P+++W 
Sbjct: 493 ---LAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWR 549

Query: 249 KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
            DG  +++  D +KY   D   +L I  +D +D+  Y C+A  +    ++   L V   P
Sbjct: 550 GDGRDLQELGDSDKYFIED--GRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 607

Query: 309 KITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGH 368
               V      +L          S  P           +I  E+K     PEK  +L   
Sbjct: 608 GP--VPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEM--APEKWYSLG-- 661

Query: 369 MVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVY 425
              +     +S TLK   Y     +  TA N  G    S   E    P+    + PV V 
Sbjct: 662 ---KVPGNQTSTTLKLSPYVHY-TFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDV- 716

Query: 426 TWEGNQVN---ITCEVFAYPSAT-------ISWFRDGQLLPSSNYSNIKIYNTPSASYLE 475
             EGN+     IT +   +           + W   G   P       +I + P   +L 
Sbjct: 717 KGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQE----QIVSDP---FLV 769

Query: 476 VTPDSENDFGNYNCTAVNRIGQESLEFILVQ---ADTPSS-PSIDQVEPYSSTAQVQFDE 531
           V+  S          AVN  G+     + +     D P + P ++ +E  +S+A +    
Sbjct: 770 VSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWR 829

Query: 532 PEATGGVP--ILKYKAEWRAVGEEVWHSKWYDAKE-----ASMEGIVTIVGLKPETTYAV 584
           P     V   +  Y   +   G +  HSK +  K+     A+   ++ + GL+P ++Y +
Sbjct: 830 PVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI-LSGLRPYSSYHL 888

Query: 585 RLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQ 620
            + A NG+G G  S  +    + V G P A  LE Q
Sbjct: 889 EVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQ 924



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 90/390 (23%), Positives = 141/390 (36%), Gaps = 56/390 (14%)

Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF-SDDSSQLTIKKVDKN----DEAEY 285
           ++L C+A G PE    WT+DG   + +E+    ++ S  S   TI   + N     +  Y
Sbjct: 48  ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIY 107

Query: 286 ICIAENKAG-EQDATIHLKVFAKPKITYVENQTAMELE--EQVTLTCE--ASGDPIPSIT 340
            C A NK G      I L     PK    E    +E+E  E V L C    S +P+    
Sbjct: 108 RCFASNKLGTAMSHEIRLMAEGAPKWP-KETVKPVEVEEGESVVLPCNPPPSAEPLRIYW 166

Query: 341 WRTSTRNISSEEKASWTRP-----EKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 395
             +   +I  +E+ +  +          T D H     HA       ++I   +  +   
Sbjct: 167 MNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPG--TRTIIQKEPIDLRV 224

Query: 396 TASNTIGQDSQSMYLEVQYAPKLQGPV----AVYTWEGNQVNITCEVFAYPSATISWFRD 451
            A+N++          +   P+L  P      +   +G  + + C    +P+ TI W R 
Sbjct: 225 KATNSM----------IDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRP 274

Query: 452 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQA--- 507
              +P+   +      T     L++    E D G Y C A N +G      ++ V+A   
Sbjct: 275 SGPMPADRVTYQNHNKT-----LQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPY 329

Query: 508 --DTPSSPSIDQVEPYSSTAQVQ-FDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKE 564
               P S      E      QVQ   +PE T           WR  G  V      D K 
Sbjct: 330 WLHKPQSHLYGPGETARLDCQVQGRPQPEVT-----------WRINGIPV-EELAKDQKY 377

Query: 565 ASMEGIVTIVGLKPETTYAVRLAALNGKGL 594
               G + +  ++P  T   +  A N  GL
Sbjct: 378 RIQRGALILSNVQPSDTMVTQCEARNRHGL 407



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 26/107 (24%), Positives = 44/107 (41%), Gaps = 6/107 (5%)

Query: 419 QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTP 478
           Q P  +  +  + +++ CE    P     W RDG          + +Y +P +    +T 
Sbjct: 35  QSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITG 94

Query: 479 DSENDF----GNYNCTAVNRIGQE-SLEFILVQADTPSSPSIDQVEP 520
           ++ N      G Y C A N++G   S E  L+    P  P  + V+P
Sbjct: 95  NNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPK-ETVKP 140


>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
           sapiens]
          Length = 1253

 Score =  126 bits (317), Expect = 8e-29
 Identities = 162/706 (22%), Positives = 271/706 (38%), Gaps = 104/706 (14%)

Query: 52  ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
           I W  P+G            V   + + TL +     +D G Y+C+     GS   A   
Sbjct: 274 IKWLRPSGPMPADR------VTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYY- 326

Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVI-LKKDVRFIVLS 170
           V +     + + P    +  GE A + C V     P + W+  G  V  L KD ++ +  
Sbjct: 327 VTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI-Q 385

Query: 171 NNYLQIRGIKKTDEGTYRCEGR-----ILARGEINFKDIQVIVNVPPTIQARQNIVNATA 225
              L +  ++ +D    +CE R     +LA   I       +V +P  I    N      
Sbjct: 386 RGALILSNVQPSDTMVTQCEARNRHGLLLANAYI------YVVQLPAKILTADNQTYMAV 439

Query: 226 NLGQSVTLVCDAEGFPEPTMSWT-KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
             G +  L+C A G P P++ W  +DG  + Q+E      F   +  L I+ +  ND   
Sbjct: 440 Q-GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDER----FFPYANGTLGIRDLQANDTGR 494

Query: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPI--PSITWR 342
           Y C+A N         +LKV    +IT     T  +   +VT TC+AS DP   PSITWR
Sbjct: 495 YFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWR 554

Query: 343 TSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 402
              R++     +     +K    DG +V+            S+ Y+D G Y C AS  + 
Sbjct: 555 GDGRDLQELGDS-----DKYFIEDGRLVIH-----------SLDYSDQGNYSCVASTELD 598

Query: 403 QDSQSMYLEVQYAPKLQGPVA------VYTWEGNQVNITCEVFAYPSATIS----WFRDG 452
                  L V  +P   GPV       ++    +QV ++       +A I      F D 
Sbjct: 599 VVESRAQLLVVGSP---GPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDK 655

Query: 453 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSS 512
           ++ P   YS  K+    +++ L+++P     F     TA+N+ G      +     TP  
Sbjct: 656 EMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTF---RVTAINKYGPGEPSPVSETVVTP-- 710

Query: 513 PSIDQVEPYSSTAQVQFDEPEATGGV-------------PILKYKAEWRAVGEEVWHSKW 559
               +  P  +   V+ +  E T  V             P ++Y+ +WR  G       W
Sbjct: 711 ----EAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGT---RGPW 763

Query: 560 YDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLG---EISAASEFKTQPVQGEPSAPK 616
            +  +   +  + +        Y +++ A+N +G G   +++     +  P     + P+
Sbjct: 764 QE--QIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYP----QAIPE 817

Query: 617 LEG--QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSE--------WKPEIRLPSGS 666
           LEG   +      +K   +        +R Y V Y    S+         K  + +P+ +
Sbjct: 818 LEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANT 877

Query: 667 DHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 712
             V+L  L   + Y + V A N +G   A+ F F T   P  +P +
Sbjct: 878 TSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFST---PEGVPGH 920



 Score =  105 bits (261), Expect = 2e-22
 Identities = 128/552 (23%), Positives = 205/552 (37%), Gaps = 86/552 (15%)

Query: 41  CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDA----GIYKC 96
           C+ +G   +    W + +G    P ++    V+    S + TI   N + A    GIY+C
Sbjct: 57  CEASGKP-EVQFRW-TRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRC 114

Query: 97  VVTGEDGSESEATVNVKIFQKLMFKNAPT-------PQEFREGEDAVIVCDVVSSLPPTI 149
             + + G+     +      +LM + AP        P E  EGE  V+ C+   S  P  
Sbjct: 115 FASNKLGTAMSHEI------RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLR 168

Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGT-YRCEGRILARGEINFK---DIQ 205
           I+    + + +K+D R  +  N  L    +  +D  + Y C         I  K   D++
Sbjct: 169 IYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLR 228

Query: 206 V------IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
           V      I   P  +    +  +  A  GQ + L C AEGFP PT+ W +    +     
Sbjct: 229 VKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPA--- 285

Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
            ++  + + +  L + KV + D+ EY C+AEN  G      ++ V A P   +       
Sbjct: 286 -DRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLY 344

Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS 379
              E   L C+  G P P +TWR +   I  EE A   + +K     G           +
Sbjct: 345 GPGETARLDCQVQGRPQPEVTWRIN--GIPVEELA---KDQKYRIQRG-----------A 388

Query: 380 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK--LQGPVAVY-TWEGNQVNITC 436
           L L ++Q +D     C A N  G    + Y+ V   P   L      Y   +G+   + C
Sbjct: 389 LILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLC 448

Query: 437 EVFAYPSATISW--------FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
           + F  P  ++ W         +D +  P +N              L +     ND G Y 
Sbjct: 449 KAFGAPVPSVQWLDEDGTTVLQDERFFPYAN------------GTLGIRDLQANDTGRYF 496

Query: 489 CTAVNRIGQESLEFILVQADT------PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 542
           C A N     ++   L   D       P S    +    + T Q  FD        P L+
Sbjct: 497 CLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFD--------PSLQ 548

Query: 543 YKAEWRAVGEEV 554
               WR  G ++
Sbjct: 549 PSITWRGDGRDL 560



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 123/516 (23%), Positives = 198/516 (38%), Gaps = 52/516 (10%)

Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190
           +G  A ++C    +  P++ W  +    +L+ D RF   +N  L IR ++  D G Y C 
Sbjct: 440 QGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQ-DERFFPYANGTLGIRDLQANDTGRYFC- 497

Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPTMSWT 248
              LA  + N   I   + V    Q  Q   +     G  VT  C A   P  +P+++W 
Sbjct: 498 ---LAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWR 554

Query: 249 KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
            DG  +++  D +KY   D   +L I  +D +D+  Y C+A  +    ++   L V   P
Sbjct: 555 GDGRDLQELGDSDKYFIED--GRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 612

Query: 309 KITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGH 368
               V      +L          S  P           +I  E+K     PEK  +L   
Sbjct: 613 GP--VPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEM--APEKWYSLG-- 666

Query: 369 MVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVY 425
              +     +S TLK   Y     +  TA N  G    S   E    P+    + PV V 
Sbjct: 667 ---KVPGNQTSTTLKLSPYVHY-TFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDV- 721

Query: 426 TWEGNQVN---ITCEVFAYPSAT-------ISWFRDGQLLPSSNYSNIKIYNTPSASYLE 475
             EGN+     IT +   +           + W   G   P       +I + P   +L 
Sbjct: 722 KGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQE----QIVSDP---FLV 774

Query: 476 VTPDSENDFGNYNCTAVNRIGQESLEFILVQ---ADTPSS-PSIDQVEPYSSTAQVQFDE 531
           V+  S          AVN  G+     + +     D P + P ++ +E  +S+A +    
Sbjct: 775 VSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWR 834

Query: 532 PEATGGVP--ILKYKAEWRAVGEEVWHSKWYDAKE-----ASMEGIVTIVGLKPETTYAV 584
           P     V   +  Y   +   G +  HSK +  K+     A+   ++ + GL+P ++Y +
Sbjct: 835 PVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI-LSGLRPYSSYHL 893

Query: 585 RLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQ 620
            + A NG+G G  S  +    + V G P A  LE Q
Sbjct: 894 EVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQ 929



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 90/390 (23%), Positives = 141/390 (36%), Gaps = 56/390 (14%)

Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF-SDDSSQLTIKKVDKN----DEAEY 285
           ++L C+A G PE    WT+DG   + +E+    ++ S  S   TI   + N     +  Y
Sbjct: 53  ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIY 112

Query: 286 ICIAENKAG-EQDATIHLKVFAKPKITYVENQTAMELE--EQVTLTCE--ASGDPIPSIT 340
            C A NK G      I L     PK    E    +E+E  E V L C    S +P+    
Sbjct: 113 RCFASNKLGTAMSHEIRLMAEGAPKWP-KETVKPVEVEEGESVVLPCNPPPSAEPLRIYW 171

Query: 341 WRTSTRNISSEEKASWTRP-----EKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 395
             +   +I  +E+ +  +          T D H     HA       ++I   +  +   
Sbjct: 172 MNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPG--TRTIIQKEPIDLRV 229

Query: 396 TASNTIGQDSQSMYLEVQYAPKLQGPV----AVYTWEGNQVNITCEVFAYPSATISWFRD 451
            A+N++          +   P+L  P      +   +G  + + C    +P+ TI W R 
Sbjct: 230 KATNSM----------IDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRP 279

Query: 452 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQA--- 507
              +P+   +      T     L++    E D G Y C A N +G      ++ V+A   
Sbjct: 280 SGPMPADRVTYQNHNKT-----LQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPY 334

Query: 508 --DTPSSPSIDQVEPYSSTAQVQ-FDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKE 564
               P S      E      QVQ   +PE T           WR  G  V      D K 
Sbjct: 335 WLHKPQSHLYGPGETARLDCQVQGRPQPEVT-----------WRINGIPV-EELAKDQKY 382

Query: 565 ASMEGIVTIVGLKPETTYAVRLAALNGKGL 594
               G + +  ++P  T   +  A N  GL
Sbjct: 383 RIQRGALILSNVQPSDTMVTQCEARNRHGL 412



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 26/107 (24%), Positives = 44/107 (41%), Gaps = 6/107 (5%)

Query: 419 QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTP 478
           Q P  +  +  + +++ CE    P     W RDG          + +Y +P +    +T 
Sbjct: 40  QSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITG 99

Query: 479 DSENDF----GNYNCTAVNRIGQE-SLEFILVQADTPSSPSIDQVEP 520
           ++ N      G Y C A N++G   S E  L+    P  P  + V+P
Sbjct: 100 NNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPK-ETVKP 145


>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
           sapiens]
          Length = 1257

 Score =  126 bits (317), Expect = 8e-29
 Identities = 162/706 (22%), Positives = 271/706 (38%), Gaps = 104/706 (14%)

Query: 52  ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
           I W  P+G            V   + + TL +     +D G Y+C+     GS   A   
Sbjct: 274 IKWLRPSGPMPADR------VTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYY- 326

Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVI-LKKDVRFIVLS 170
           V +     + + P    +  GE A + C V     P + W+  G  V  L KD ++ +  
Sbjct: 327 VTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI-Q 385

Query: 171 NNYLQIRGIKKTDEGTYRCEGR-----ILARGEINFKDIQVIVNVPPTIQARQNIVNATA 225
              L +  ++ +D    +CE R     +LA   I       +V +P  I    N      
Sbjct: 386 RGALILSNVQPSDTMVTQCEARNRHGLLLANAYI------YVVQLPAKILTADNQTYMAV 439

Query: 226 NLGQSVTLVCDAEGFPEPTMSWT-KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
             G +  L+C A G P P++ W  +DG  + Q+E      F   +  L I+ +  ND   
Sbjct: 440 Q-GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDER----FFPYANGTLGIRDLQANDTGR 494

Query: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPI--PSITWR 342
           Y C+A N         +LKV    +IT     T  +   +VT TC+AS DP   PSITWR
Sbjct: 495 YFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWR 554

Query: 343 TSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 402
              R++     +     +K    DG +V+            S+ Y+D G Y C AS  + 
Sbjct: 555 GDGRDLQELGDS-----DKYFIEDGRLVIH-----------SLDYSDQGNYSCVASTELD 598

Query: 403 QDSQSMYLEVQYAPKLQGPVA------VYTWEGNQVNITCEVFAYPSATIS----WFRDG 452
                  L V  +P   GPV       ++    +QV ++       +A I      F D 
Sbjct: 599 VVESRAQLLVVGSP---GPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDK 655

Query: 453 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSS 512
           ++ P   YS  K+    +++ L+++P     F     TA+N+ G      +     TP  
Sbjct: 656 EMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTF---RVTAINKYGPGEPSPVSETVVTP-- 710

Query: 513 PSIDQVEPYSSTAQVQFDEPEATGGV-------------PILKYKAEWRAVGEEVWHSKW 559
               +  P  +   V+ +  E T  V             P ++Y+ +WR  G       W
Sbjct: 711 ----EAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGT---RGPW 763

Query: 560 YDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLG---EISAASEFKTQPVQGEPSAPK 616
            +  +   +  + +        Y +++ A+N +G G   +++     +  P     + P+
Sbjct: 764 QE--QIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYP----QAIPE 817

Query: 617 LEG--QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSE--------WKPEIRLPSGS 666
           LEG   +      +K   +        +R Y V Y    S+         K  + +P+ +
Sbjct: 818 LEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANT 877

Query: 667 DHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 712
             V+L  L   + Y + V A N +G   A+ F F T   P  +P +
Sbjct: 878 TSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFST---PEGVPGH 920



 Score =  105 bits (261), Expect = 2e-22
 Identities = 128/552 (23%), Positives = 205/552 (37%), Gaps = 86/552 (15%)

Query: 41  CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDA----GIYKC 96
           C+ +G   +    W + +G    P ++    V+    S + TI   N + A    GIY+C
Sbjct: 57  CEASGKP-EVQFRW-TRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRC 114

Query: 97  VVTGEDGSESEATVNVKIFQKLMFKNAPT-------PQEFREGEDAVIVCDVVSSLPPTI 149
             + + G+     +      +LM + AP        P E  EGE  V+ C+   S  P  
Sbjct: 115 FASNKLGTAMSHEI------RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLR 168

Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGT-YRCEGRILARGEINFK---DIQ 205
           I+    + + +K+D R  +  N  L    +  +D  + Y C         I  K   D++
Sbjct: 169 IYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLR 228

Query: 206 V------IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
           V      I   P  +    +  +  A  GQ + L C AEGFP PT+ W +    +     
Sbjct: 229 VKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPA--- 285

Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
            ++  + + +  L + KV + D+ EY C+AEN  G      ++ V A P   +       
Sbjct: 286 -DRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLY 344

Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS 379
              E   L C+  G P P +TWR +   I  EE A   + +K     G           +
Sbjct: 345 GPGETARLDCQVQGRPQPEVTWRIN--GIPVEELA---KDQKYRIQRG-----------A 388

Query: 380 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK--LQGPVAVY-TWEGNQVNITC 436
           L L ++Q +D     C A N  G    + Y+ V   P   L      Y   +G+   + C
Sbjct: 389 LILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLC 448

Query: 437 EVFAYPSATISW--------FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 488
           + F  P  ++ W         +D +  P +N              L +     ND G Y 
Sbjct: 449 KAFGAPVPSVQWLDEDGTTVLQDERFFPYAN------------GTLGIRDLQANDTGRYF 496

Query: 489 CTAVNRIGQESLEFILVQADT------PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 542
           C A N     ++   L   D       P S    +    + T Q  FD        P L+
Sbjct: 497 CLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFD--------PSLQ 548

Query: 543 YKAEWRAVGEEV 554
               WR  G ++
Sbjct: 549 PSITWRGDGRDL 560



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 123/516 (23%), Positives = 198/516 (38%), Gaps = 52/516 (10%)

Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190
           +G  A ++C    +  P++ W  +    +L+ D RF   +N  L IR ++  D G Y C 
Sbjct: 440 QGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQ-DERFFPYANGTLGIRDLQANDTGRYFC- 497

Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPTMSWT 248
              LA  + N   I   + V    Q  Q   +     G  VT  C A   P  +P+++W 
Sbjct: 498 ---LAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWR 554

Query: 249 KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
            DG  +++  D +KY   D   +L I  +D +D+  Y C+A  +    ++   L V   P
Sbjct: 555 GDGRDLQELGDSDKYFIED--GRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 612

Query: 309 KITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGH 368
               V      +L          S  P           +I  E+K     PEK  +L   
Sbjct: 613 GP--VPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEM--APEKWYSLG-- 666

Query: 369 MVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVY 425
              +     +S TLK   Y     +  TA N  G    S   E    P+    + PV V 
Sbjct: 667 ---KVPGNQTSTTLKLSPYVHY-TFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDV- 721

Query: 426 TWEGNQVN---ITCEVFAYPSAT-------ISWFRDGQLLPSSNYSNIKIYNTPSASYLE 475
             EGN+     IT +   +           + W   G   P       +I + P   +L 
Sbjct: 722 KGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQE----QIVSDP---FLV 774

Query: 476 VTPDSENDFGNYNCTAVNRIGQESLEFILVQ---ADTPSS-PSIDQVEPYSSTAQVQFDE 531
           V+  S          AVN  G+     + +     D P + P ++ +E  +S+A +    
Sbjct: 775 VSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWR 834

Query: 532 PEATGGVP--ILKYKAEWRAVGEEVWHSKWYDAKE-----ASMEGIVTIVGLKPETTYAV 584
           P     V   +  Y   +   G +  HSK +  K+     A+   ++ + GL+P ++Y +
Sbjct: 835 PVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI-LSGLRPYSSYHL 893

Query: 585 RLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQ 620
            + A NG+G G  S  +    + V G P A  LE Q
Sbjct: 894 EVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQ 929



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 90/390 (23%), Positives = 141/390 (36%), Gaps = 56/390 (14%)

Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF-SDDSSQLTIKKVDKN----DEAEY 285
           ++L C+A G PE    WT+DG   + +E+    ++ S  S   TI   + N     +  Y
Sbjct: 53  ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIY 112

Query: 286 ICIAENKAG-EQDATIHLKVFAKPKITYVENQTAMELE--EQVTLTCE--ASGDPIPSIT 340
            C A NK G      I L     PK    E    +E+E  E V L C    S +P+    
Sbjct: 113 RCFASNKLGTAMSHEIRLMAEGAPKWP-KETVKPVEVEEGESVVLPCNPPPSAEPLRIYW 171

Query: 341 WRTSTRNISSEEKASWTRP-----EKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 395
             +   +I  +E+ +  +          T D H     HA       ++I   +  +   
Sbjct: 172 MNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPG--TRTIIQKEPIDLRV 229

Query: 396 TASNTIGQDSQSMYLEVQYAPKLQGPV----AVYTWEGNQVNITCEVFAYPSATISWFRD 451
            A+N++          +   P+L  P      +   +G  + + C    +P+ TI W R 
Sbjct: 230 KATNSM----------IDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRP 279

Query: 452 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQA--- 507
              +P+   +      T     L++    E D G Y C A N +G      ++ V+A   
Sbjct: 280 SGPMPADRVTYQNHNKT-----LQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPY 334

Query: 508 --DTPSSPSIDQVEPYSSTAQVQ-FDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKE 564
               P S      E      QVQ   +PE T           WR  G  V      D K 
Sbjct: 335 WLHKPQSHLYGPGETARLDCQVQGRPQPEVT-----------WRINGIPV-EELAKDQKY 382

Query: 565 ASMEGIVTIVGLKPETTYAVRLAALNGKGL 594
               G + +  ++P  T   +  A N  GL
Sbjct: 383 RIQRGALILSNVQPSDTMVTQCEARNRHGL 412



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 26/107 (24%), Positives = 44/107 (41%), Gaps = 6/107 (5%)

Query: 419 QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTP 478
           Q P  +  +  + +++ CE    P     W RDG          + +Y +P +    +T 
Sbjct: 40  QSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITG 99

Query: 479 DSENDF----GNYNCTAVNRIGQE-SLEFILVQADTPSSPSIDQVEP 520
           ++ N      G Y C A N++G   S E  L+    P  P  + V+P
Sbjct: 100 NNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPK-ETVKP 145


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.130    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,830,527
Number of Sequences: 37866
Number of extensions: 1668814
Number of successful extensions: 13431
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 280
Number of HSP's successfully gapped in prelim test: 294
Number of HSP's that attempted gapping in prelim test: 4967
Number of HSP's gapped (non-prelim): 3621
length of query: 858
length of database: 18,247,518
effective HSP length: 111
effective length of query: 747
effective length of database: 14,044,392
effective search space: 10491160824
effective search space used: 10491160824
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.