BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|22749275 CDC20 cell division cycle 20 homolog B isoform 1 [Homo sapiens] (515 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|22749275 CDC20 cell division cycle 20 homolog B isoform 1 [Ho... 1055 0.0 gi|224593764 CDC20 cell division cycle 20 homolog B isoform 2 [H... 936 0.0 gi|118402582 cell division cycle 20 [Homo sapiens] 306 2e-83 gi|209969680 Fzr1 protein isoform 1 [Homo sapiens] 208 8e-54 gi|33620742 Fzr1 protein isoform 2 [Homo sapiens] 208 8e-54 gi|209969678 Fzr1 protein isoform 3 [Homo sapiens] 175 1e-43 gi|16554629 WD repeat domain 5 [Homo sapiens] 67 5e-11 gi|16554627 WD repeat domain 5 [Homo sapiens] 67 5e-11 gi|23199987 WD repeat domain 5B [Homo sapiens] 63 6e-10 gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 62 1e-09 gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 61 3e-09 gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 59 1e-08 gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 55 1e-07 gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 55 1e-07 gi|21071067 TBP-associated factor 5 [Homo sapiens] 54 3e-07 gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 54 4e-07 gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 52 1e-06 gi|157739942 gemin 5 [Homo sapiens] 52 1e-06 gi|113865883 WD repeat domain 38 [Homo sapiens] 52 1e-06 gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens] 52 1e-06 gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens] 52 1e-06 gi|19913367 transducin beta-like 1Y [Homo sapiens] 52 1e-06 gi|19913365 transducin beta-like 1Y [Homo sapiens] 52 1e-06 gi|15150805 transducin beta-like 1Y [Homo sapiens] 52 1e-06 gi|45594312 TNF receptor-associated factor 7 [Homo sapiens] 51 2e-06 gi|41281447 intraflagellar transport 140 [Homo sapiens] 51 2e-06 gi|32189425 WD repeat domain 69 [Homo sapiens] 51 3e-06 gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 49 8e-06 gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 49 8e-06 gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 49 8e-06 >gi|22749275 CDC20 cell division cycle 20 homolog B isoform 1 [Homo sapiens] Length = 515 Score = 1055 bits (2728), Expect = 0.0 Identities = 515/515 (100%), Positives = 515/515 (100%) Query: 1 MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAK 60 MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAK Sbjct: 1 MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAK 60 Query: 61 RLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGS 120 RLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGS Sbjct: 61 RLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGS 120 Query: 121 CKEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANG 180 CKEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANG Sbjct: 121 CKEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANG 180 Query: 181 KMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWS 240 KMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWS Sbjct: 181 KMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWS 240 Query: 241 FQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLW 300 FQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLW Sbjct: 241 FQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLW 300 Query: 301 DVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCA 360 DVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCA Sbjct: 301 DVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCA 360 Query: 361 LKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIG 420 LKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIG Sbjct: 361 LKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIG 420 Query: 421 GGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS 480 GGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS Sbjct: 421 GGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS 480 Query: 481 RSGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 515 RSGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY Sbjct: 481 RSGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 515 >gi|224593764 CDC20 cell division cycle 20 homolog B isoform 2 [Homo sapiens] Length = 477 Score = 936 bits (2419), Expect = 0.0 Identities = 472/519 (90%), Positives = 472/519 (90%), Gaps = 46/519 (8%) Query: 1 MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAK 60 MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAK Sbjct: 1 MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAK 60 Query: 61 RLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGS 120 RLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGS Sbjct: 61 RLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGS 120 Query: 121 CKEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANG 180 KEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANG Sbjct: 121 RKEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANG 180 Query: 181 KMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWS 240 KMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWS Sbjct: 181 KMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWS 240 Query: 241 FQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLW 300 FQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLW Sbjct: 241 FQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLW 300 Query: 301 DVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCA 360 DVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCA Sbjct: 301 DVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCA 360 Query: 361 LKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIG 420 LKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVK Sbjct: 361 LKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVK--------------- 405 Query: 421 GGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS 480 ICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS Sbjct: 406 ---------------------------ICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS 438 Query: 481 RS----GHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 515 RS GHRGRVLHLALSPDQTRVFSAAADGTASVWNCY Sbjct: 439 RSGGFFGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 477 >gi|118402582 cell division cycle 20 [Homo sapiens] Length = 499 Score = 306 bits (785), Expect = 2e-83 Identities = 147/294 (50%), Positives = 199/294 (67%), Gaps = 7/294 (2%) Query: 228 LRNDYYLNILDWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTC 287 +RNDYYLN++DWS N++A+AL ++VY+W+ + + ++ + + YISSV+WIKEG Sbjct: 181 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY 240 Query: 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQH 347 LAVGTS EVQLWDV +KRLRNM H + VG+LSWN +ILSSGSR G ++HHDVRVA+H Sbjct: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH 300 Query: 348 HVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQ-STAVK 405 HV TL H Q VC L+W+PDGR L+SG +D L+ +WP PG PL+ TQ AVK Sbjct: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG-WVPLQTFTQHQGAVK 359 Query: 406 AMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQG 465 A+ WCPWQS VLA GGG D + I ++ +G + +SQ+CS++W P KE+ +G G Sbjct: 360 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHG 419 Query: 466 TPKNDVTVWTCPTVSR----SGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 515 +N + +W PT+++ GH RVL L +SPD V SAAAD T +W C+ Sbjct: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 >gi|209969680 Fzr1 protein isoform 1 [Homo sapiens] Length = 496 Score = 208 bits (530), Expect = 8e-54 Identities = 110/294 (37%), Positives = 165/294 (56%), Gaps = 10/294 (3%) Query: 228 LRNDYYLNILDWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTC 287 L++D+YLN++DWS N++++ LG+ VY+W+ DLS+ + ++SV W + G Sbjct: 184 LQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNL 243 Query: 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRV--A 345 +AVGT +G VQ+WD K+L + GH + VGAL+WN LSSGSR + D+R Sbjct: 244 VAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPL 303 Query: 346 QHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVK 405 Q H+Q VC LKWS D +LL+SG +D L +W H + Q + AVK Sbjct: 304 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ----QYTEHLAAVK 359 Query: 406 AMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQG 465 A+ W P Q G+LA GGG D + + G+ +Q T SQ+C+L W E+ + G Sbjct: 360 AIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHG 419 Query: 466 TPKNDVTVWTCPTVSR----SGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 515 +N + VW P++++ +GH RVL+LA+SPD + + A D T WN + Sbjct: 420 YSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVF 473 >gi|33620742 Fzr1 protein isoform 2 [Homo sapiens] Length = 493 Score = 208 bits (530), Expect = 8e-54 Identities = 110/294 (37%), Positives = 165/294 (56%), Gaps = 10/294 (3%) Query: 228 LRNDYYLNILDWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTC 287 L++D+YLN++DWS N++++ LG+ VY+W+ DLS+ + ++SV W + G Sbjct: 184 LQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNL 243 Query: 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRV--A 345 +AVGT +G VQ+WD K+L + GH + VGAL+WN LSSGSR + D+R Sbjct: 244 VAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPL 303 Query: 346 QHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVK 405 Q H+Q VC LKWS D +LL+SG +D L +W H + Q + AVK Sbjct: 304 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ----QYTEHLAAVK 359 Query: 406 AMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQG 465 A+ W P Q G+LA GGG D + + G+ +Q T SQ+C+L W E+ + G Sbjct: 360 AIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHG 419 Query: 466 TPKNDVTVWTCPTVSR----SGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 515 +N + VW P++++ +GH RVL+LA+SPD + + A D T WN + Sbjct: 420 YSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVF 473 >gi|209969678 Fzr1 protein isoform 3 [Homo sapiens] Length = 404 Score = 175 bits (443), Expect = 1e-43 Identities = 96/254 (37%), Positives = 139/254 (54%), Gaps = 10/254 (3%) Query: 268 DLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFI 327 DLS+ + ++SV W + G +AVGT +G VQ+WD K+L + GH + VGAL+WN Sbjct: 135 DLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ 194 Query: 328 LSSGSRLGRVYHHDVRV--AQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHD 385 LSSGSR + D+R Q H+Q VC LKWS D +LL+SG +D L +W H Sbjct: 195 LSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHS 254 Query: 386 PGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTN 445 + Q + AVKA+ W P Q G+LA GGG D + + G+ +Q T Sbjct: 255 SLSPVQ----QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTG 310 Query: 446 SQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVSR----SGHRGRVLHLALSPDQTRVF 501 SQ+C+L W E+ + G +N + VW P++++ +GH RVL+LA+SPD + Sbjct: 311 SQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIV 370 Query: 502 SAAADGTASVWNCY 515 + A D T WN + Sbjct: 371 TGAGDETLRFWNVF 384 >gi|16554629 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 66.6 bits (161), Expect = 5e-11 Identities = 66/249 (26%), Positives = 105/249 (42%), Gaps = 20/249 (8%) Query: 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--HFILSSGSR 333 IS V+W + L + + +++WDV + K L+ + GH + V ++N ++ SGS Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 Query: 334 LGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQ 393 V DV+ + H V A+ ++ DG L+ S DGL IW +A GQ Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD-----TASGQ 204 Query: 394 PLKVI--TQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPS--TNSQIC 449 LK + + V + + P +LA D L + D + GK ++T + N + C Sbjct: 205 CLKTLIDDDNPPVSFVKFSPNGKYILA---ATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261 Query: 450 SLIWLPKTKEIATGQGTPKNDVTVWTCPT----VSRSGHRGRVLHLALSPDQTRVFSAAA 505 T G+ N V +W T GH V+ A P + + SAA Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321 Query: 506 --DGTASVW 512 D T +W Sbjct: 322 ENDKTIKLW 330 Score = 43.9 bits (102), Expect = 4e-04 Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 14/165 (8%) Query: 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQ 413 H +AV ++K+SP+G L+S +D L+ IW G + T S + W Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK-------TISGHKLGISDVAWS 96 Query: 414 SGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQ-ICSLIWLPKTKEIATGQGTPKNDVT 472 S + D L I D+++GK ++T +S + + P++ I + G+ V Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS--GSFDESVR 154 Query: 473 VWTCPT----VSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 +W T + H V + + D + + S++ DG +W+ Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199 >gi|16554627 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 66.6 bits (161), Expect = 5e-11 Identities = 66/249 (26%), Positives = 105/249 (42%), Gaps = 20/249 (8%) Query: 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--HFILSSGSR 333 IS V+W + L + + +++WDV + K L+ + GH + V ++N ++ SGS Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 Query: 334 LGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQ 393 V DV+ + H V A+ ++ DG L+ S DGL IW +A GQ Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD-----TASGQ 204 Query: 394 PLKVI--TQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPS--TNSQIC 449 LK + + V + + P +LA D L + D + GK ++T + N + C Sbjct: 205 CLKTLIDDDNPPVSFVKFSPNGKYILA---ATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261 Query: 450 SLIWLPKTKEIATGQGTPKNDVTVWTCPT----VSRSGHRGRVLHLALSPDQTRVFSAAA 505 T G+ N V +W T GH V+ A P + + SAA Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321 Query: 506 --DGTASVW 512 D T +W Sbjct: 322 ENDKTIKLW 330 Score = 43.9 bits (102), Expect = 4e-04 Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 14/165 (8%) Query: 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQ 413 H +AV ++K+SP+G L+S +D L+ IW G + T S + W Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK-------TISGHKLGISDVAWS 96 Query: 414 SGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQ-ICSLIWLPKTKEIATGQGTPKNDVT 472 S + D L I D+++GK ++T +S + + P++ I + G+ V Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS--GSFDESVR 154 Query: 473 VWTCPT----VSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 +W T + H V + + D + + S++ DG +W+ Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199 >gi|23199987 WD repeat domain 5B [Homo sapiens] Length = 330 Score = 63.2 bits (152), Expect = 6e-10 Identities = 64/249 (25%), Positives = 105/249 (42%), Gaps = 20/249 (8%) Query: 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--HFILSSGSR 333 IS V+W + + L + + ++LWDV + K L+ + GH + V ++N ++ SGS Sbjct: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSF 145 Query: 334 LGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQ 393 V +V+ + H V A+ ++ G L+ SG DGL IW +A GQ Sbjct: 146 DETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD-----AASGQ 200 Query: 394 PLKVIT--QSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPS--TNSQIC 449 LK + + V + + P +L D L + D + G+ ++T + N + C Sbjct: 201 CLKTLVDDDNPPVSFVKFSPNGKYILT---ATLDNTLKLWDYSRGRCLKTYTGHKNEKYC 257 Query: 450 SLIWLPKTKEIATGQGTPKNDVTVWTCPT----VSRSGHRGRVLHLALSPDQTRVFSAAA 505 T G+ N V +W T GH V+ A P + + SAA Sbjct: 258 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAAL 317 Query: 506 --DGTASVW 512 D T +W Sbjct: 318 ENDKTIKLW 326 Score = 42.7 bits (99), Expect = 8e-04 Identities = 53/224 (23%), Positives = 94/224 (41%), Gaps = 27/224 (12%) Query: 265 ENIDLSLTCNYI------SSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVV 318 EN + +L C + SSV + G LA +++ + +W K + + GH + Sbjct: 27 ENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEI 86 Query: 319 GALSW----NHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGC 374 ++W + + +S + +++ DVR + H V ++P L+ SG Sbjct: 87 SDVAWSSDSSRLVSASDDKTLKLW--DVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGS 144 Query: 375 SDGLLTIWPHDPGASAQGQPLKVIT-QSTAVKAMDW-CPWQSGVLAIGGGMKDGRLHILD 432 D + IW G+ LK ++ S V A+ + C SG L + G DG I D Sbjct: 145 FDETVKIW-----EVKTGKCLKTLSAHSDPVSAVHFNC---SGSLIVSGSY-DGLCRIWD 195 Query: 433 INAGKSIQT--PSTNSQICSLIWLPKTKEIATGQGTPKNDVTVW 474 +G+ ++T N + + + P K I T T N + +W Sbjct: 196 AASGQCLKTLVDDDNPPVSFVKFSPNGKYILT--ATLDNTLKLW 237 Score = 40.8 bits (94), Expect = 0.003 Identities = 39/169 (23%), Positives = 69/169 (40%), Gaps = 22/169 (13%) Query: 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPG---ASAQGQPLKVITQSTAVKAMDWC 410 H +AV ++K+SP+G L+S +D L+ IW G + G L++ + Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVA--------- 90 Query: 411 PWQSGVLAIGGGMKDGRLHILDINAGKSIQT--PSTNSQICSLIWLPKTKEIATGQGTPK 468 W S + D L + D+ +GK ++T +N C P I+ G+ Sbjct: 91 -WSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIIS---GSFD 146 Query: 469 NDVTVWTCPT----VSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 V +W T + S H V + + + + S + DG +W+ Sbjct: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195 >gi|62234461 Notchless gene homolog isoform a [Homo sapiens] Length = 485 Score = 62.4 bits (150), Expect = 1e-09 Identities = 75/331 (22%), Positives = 134/331 (40%), Gaps = 50/331 (15%) Query: 214 DSILQPEVKIHITGLRNDYYLNILDWSFQNLVAIALG-SAVYIWNGENHNGIENIDLS-- 270 D I QP+ + + + L+ + ++++A + Y+ +G + DLS Sbjct: 89 DIIYQPQAIFRVRAVTR--CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTE 146 Query: 271 ---LTC----NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRL-RNMLGHLSVVGALS 322 TC +++ S+SW +G LA G G++ LWD T K++ R + GH + LS Sbjct: 147 TPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLS 206 Query: 323 WNHF-------ILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCS 375 W ++S S+ G V D + H Q+V L+W DG LL S Sbjct: 207 WEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQ 265 Query: 376 DGLLTIWPHDPGA-----SAQGQPLKVITQST--AVKAMDWCPWQSGV--LAIGGG---M 423 D + +W G G + + ST A++ + P ++ V + G + Sbjct: 266 DRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQEL 325 Query: 424 KDGRLHILDINAGKSIQTPSTNSQICSL-IWLPKTKEIATGQGTPKNDVTVWTCPTVSRS 482 K+ L ++ G+ + + S +L +W P + P + Sbjct: 326 KERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDK----------------KPLTRMT 369 Query: 483 GHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 GH+ + + SPD V SA+ D + +W+ Sbjct: 370 GHQALINQVLFSPDSRIVASASFDKSIKLWD 400 Score = 55.5 bits (132), Expect = 1e-07 Identities = 33/109 (30%), Positives = 57/109 (52%), Gaps = 2/109 (1%) Query: 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--HFILSSGSR 333 I+ V + + +A + + ++LWD T K L ++ GH++ V ++W+ +L SGS Sbjct: 375 INQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSS 434 Query: 334 LGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382 + DV+ + + H V A+ WSPDG+ ++SG D L IW Sbjct: 435 DSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483 >gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [Homo sapiens] Length = 340 Score = 60.8 bits (146), Expect = 3e-09 Identities = 66/286 (23%), Positives = 112/286 (39%), Gaps = 31/286 (10%) Query: 244 LVAIALGSAVYIWNGENHNGIENIDLS----LTCNYISSVSWIKEG------TCLAVGTS 293 LV+ + + IW+ N + I L +TC Y S +++ G + ++ T Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTR 129 Query: 294 EGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLR 353 EG V++ + L G+LS L N I SSG ++ D+ Q VG Sbjct: 130 EGNVRV-----SRELPGHTGYLSCCRFLDDNQIITSSGDTTCALW--DIETGQQTVGFAG 182 Query: 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQ 413 H V +L +PDGR SG D + +W Q I + + A+ + P Sbjct: 183 HSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQ----TFIGHESDINAVAFFP-- 236 Query: 414 SGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSL--IWLPKTKEIATGQGTPKNDV 471 A G D + D+ A + + S ++ IC + + ++ + G + Sbjct: 237 -NGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLA-GYDDFNC 294 Query: 472 TVWTCPTVSR----SGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 +W R +GH RV L ++ D V + + D +WN Sbjct: 295 NIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 Score = 47.8 bits (112), Expect = 2e-05 Identities = 47/172 (27%), Positives = 68/172 (39%), Gaps = 18/172 (10%) Query: 351 TLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDW 409 TLR H + A+ W D RLL S DG L IW PL+ S+ V + Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR----SSWVMTCAY 105 Query: 410 CPWQSGVLAIGGGMKD----GRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQG 465 P SG GG+ + L + N S + P + +L + I + Sbjct: 106 AP--SGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGD 163 Query: 466 TPKNDVTVWTC----PTVSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 T +W TV +GH G V+ L+L+PD S A D + +W+ Sbjct: 164 T---TCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWD 212 >gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [Homo sapiens] Length = 340 Score = 58.5 bits (140), Expect = 1e-08 Identities = 67/286 (23%), Positives = 111/286 (38%), Gaps = 31/286 (10%) Query: 244 LVAIALGSAVYIWNGENHNGIENIDLS----LTCNYISSVSWIKEG------TCLAVGTS 293 LV+ + + IW+ N + I L +TC Y S +++ G + + T Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129 Query: 294 EGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLR 353 EG V++ + L G+LS L N + SSG ++ D+ Q Sbjct: 130 EGNVRV-----SRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW--DIETGQQTTTFTG 182 Query: 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQ 413 H V +L +PD RL SG D +W G Q + + A+ C + Sbjct: 183 HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ----TFTGHESDINAI--CFFP 236 Query: 414 SGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSL--IWLPKTKEIATGQGTPKNDV 471 +G A G D + D+ A + + T S ++ IC + + K+ + G + Sbjct: 237 NG-NAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA-GYDDFNC 294 Query: 472 TVWTCPTVSR----SGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 VW R +GH RV L ++ D V + + D +WN Sbjct: 295 NVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 Score = 45.4 bits (106), Expect = 1e-04 Identities = 48/186 (25%), Positives = 72/186 (38%), Gaps = 46/186 (24%) Query: 351 TLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDW 409 TLR H + A+ W D RLL S DG L IW PL+ S+ V + Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR----SSWVMTCAY 105 Query: 410 CPWQSGVLAIGGGM-----------KDGRLHILDINAGKS-----------IQTPSTNSQ 447 P SG GG+ ++G + + AG + Q +++ Sbjct: 106 AP--SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD 163 Query: 448 ICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVSRSGHRGRVLHLALSPDQTRVFSAAADG 507 +W +I TGQ T + +GH G V+ L+L+PD S A D Sbjct: 164 TTCALW-----DIETGQ------------QTTTFTGHTGDVMSLSLAPDTRLFVSGACDA 206 Query: 508 TASVWN 513 +A +W+ Sbjct: 207 SAKLWD 212 >gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] Length = 357 Score = 55.5 bits (132), Expect = 1e-07 Identities = 45/165 (27%), Positives = 76/165 (46%), Gaps = 14/165 (8%) Query: 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWC-PW 412 H AV L ++ DG +L S +D + +W S G+ +K + T+ ++ C P Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWD-----SETGERVKRLKGHTSF--VNSCYPA 160 Query: 413 QSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVT 472 + G + G DG + + DI +IQT Q+ ++ + + +I + G ND+ Sbjct: 161 RRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIIS--GGIDNDIK 218 Query: 473 VWTCP----TVSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 VW T + GH V L+LS + + + S A D T VW+ Sbjct: 219 VWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 263 Score = 40.0 bits (92), Expect = 0.005 Identities = 55/249 (22%), Positives = 97/249 (38%), Gaps = 46/249 (18%) Query: 284 EGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGA---LSWNHFILSSGSRLGRVYHH 340 +G+ L +++ V +WD T +R++ + GH S V + ++ +GS G V Sbjct: 120 DGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLW 179 Query: 341 DVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWP------------HDPGA 388 D+R + + T ++ V A+ ++ + SG D + +W H Sbjct: 180 DIR-KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSV 238 Query: 389 -----SAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPS 443 S++G L V+ D P+ + + G +H + N + Sbjct: 239 TGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCV--KIFQGNVHNFEKNLLR------ 290 Query: 444 TNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVSR------SGHRGRVLHLALSPDQ 497 CS W P +IA G D V+ T SR GH G + +A PD+ Sbjct: 291 -----CS--WSPDGSKIAAGSA----DRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE 339 Query: 498 TRVFSAAAD 506 + SA++D Sbjct: 340 PIIISASSD 348 Score = 35.8 bits (81), Expect = 0.096 Identities = 24/93 (25%), Positives = 48/93 (51%), Gaps = 11/93 (11%) Query: 253 VYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNML 312 V I+ G HN +N+ L C SW +G+ +A G+++ V +WD +++ L + Sbjct: 274 VKIFQGNVHNFEKNL---LRC------SWSPDGSKIAAGSADRFVYVWDTTSRRILYKLP 324 Query: 313 GHLSVVGALSW--NHFILSSGSRLGRVYHHDVR 343 GH + +++ + I+ S S R+Y +++ Sbjct: 325 GHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357 Score = 32.0 bits (71), Expect = 1.4 Identities = 13/31 (41%), Positives = 20/31 (64%) Query: 483 GHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 GH G V+ L + D + +FSA+ D T +VW+ Sbjct: 107 GHSGAVMELHYNTDGSMLFSASTDKTVAVWD 137 >gi|62234438 Notchless gene homolog isoform b [Homo sapiens] Length = 193 Score = 55.5 bits (132), Expect = 1e-07 Identities = 33/109 (30%), Positives = 57/109 (52%), Gaps = 2/109 (1%) Query: 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--HFILSSGSR 333 I+ V + + +A + + ++LWD T K L ++ GH++ V ++W+ +L SGS Sbjct: 83 INQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSS 142 Query: 334 LGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382 + DV+ + + H V A+ WSPDG+ ++SG D L IW Sbjct: 143 DSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 191 Score = 37.7 bits (86), Expect = 0.025 Identities = 26/114 (22%), Positives = 50/114 (43%), Gaps = 14/114 (12%) Query: 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPG---ASAQGQPLKVITQSTAVKAMDWC 410 H+ + + +SPD R+++S D + +W G AS +G V A+ Sbjct: 79 HQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGH----------VAAVYQI 128 Query: 411 PWQSGVLAIGGGMKDGRLHILDINAGK-SIQTPSTNSQICSLIWLPKTKEIATG 463 W + + G D L + D+ A K ++ P ++ ++ W P + +A+G Sbjct: 129 AWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASG 182 >gi|21071067 TBP-associated factor 5 [Homo sapiens] Length = 800 Score = 54.3 bits (129), Expect = 3e-07 Identities = 33/98 (33%), Positives = 56/98 (57%), Gaps = 4/98 (4%) Query: 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW--NHFILSSGSRLGRVYHHDVRVA 345 +A G+++ V+LWDV+ +R GH + +L++ N L++G+ GRV D+ Sbjct: 642 VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701 Query: 346 QHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIW 382 VG L+ H VC+L++S DG +L+SG D + +W Sbjct: 702 LM-VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738 Score = 39.3 bits (90), Expect = 0.009 Identities = 56/225 (24%), Positives = 89/225 (39%), Gaps = 20/225 (8%) Query: 298 QLWDVVTKKRLRNMLGHLSVVGALSWN---HFILSSGSRLGRVYHHDVRVAQHHVGTLRH 354 ++ D T L+ + GH V S++ +++LSS S G V ++ VG H Sbjct: 526 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSS-SEDGTVRLWSLQTFTCLVGYKGH 584 Query: 355 KQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTA-VKAMDWCPWQ 413 V ++SP G SG D + +W D QPL++ A V + P Sbjct: 585 NYPVWDTQFSPYGYYFVSGGHDRVARLWATD-----HYQPLRIFAGHLADVNCTRFHP-N 638 Query: 414 SGVLAIGGGMKDGRLHILDINAGKSIQT-PSTNSQICSLIWLPKTKEIATGQGTPKNDVT 472 S +A G D + + D+ G ++ I SL + P + +ATG + V Sbjct: 639 SNYVATGSA--DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGR--VL 694 Query: 473 VWTCP----TVSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 +W GH V L S D + S + D T +W+ Sbjct: 695 LWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 38.9 bits (89), Expect = 0.011 Identities = 57/249 (22%), Positives = 93/249 (37%), Gaps = 35/249 (14%) Query: 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLG 335 +++V + + +A G ++ V++W V T K+LR SV A + S L Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSV-TPKKLR------SVKQASDLSLIDKESDDVLE 525 Query: 336 RVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPL 395 R+ D + A H V +SPD L S DG + +W L Sbjct: 526 RIM--DEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWS-----------L 572 Query: 396 KVITQSTAVKAMDWCPWQS-----GVLAIGGGM-KDGRLHILDINAGKSIQTPSTNSQIC 449 + T K ++ W + G + GG + RL D I C Sbjct: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 632 Query: 450 SLIWLPKTKEIATGQGTPKNDVTVW-----TCPTVSRSGHRGRVLHLALSPDQTRVFSAA 504 + P + +ATG V +W C + +GH+G + L SP+ + + A Sbjct: 633 TRFH-PNSNYVATGSAD--RTVRLWDVLNGNCVRIF-TGHKGPIHSLTFSPNGRFLATGA 688 Query: 505 ADGTASVWN 513 DG +W+ Sbjct: 689 TDGRVLLWD 697 >gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [Homo sapiens] Length = 340 Score = 53.5 bits (127), Expect = 4e-07 Identities = 67/295 (22%), Positives = 113/295 (38%), Gaps = 33/295 (11%) Query: 237 LDWSFQN--LVAIALGSAVYIWNGENHNGIENIDLS----LTCNYISSVSWIKEG----- 285 + W + + LV+ + + IW+ N + I L +TC Y S +++ G Sbjct: 61 MHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120 Query: 286 -TCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRV 344 + + T EG V++ + L G+LS L + + SSG ++ D+ Sbjct: 121 CSIYNLKTREGNVRV-----SRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALW--DIET 173 Query: 345 AQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAV 404 AQ H V +L SPD R SG D +W G Q V + + Sbjct: 174 AQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHV----SDI 229 Query: 405 KAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSL--IWLPKTKEIAT 462 A+ + P A G D + D+ A + + S ++ IC + + K+ + Sbjct: 230 NAVSFFP---NGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLL 286 Query: 463 GQGTPKNDVTVWTCPTVSR----SGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 G + VW R +GH RV L ++ D V + + D +WN Sbjct: 287 A-GYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340 Score = 49.7 bits (117), Expect = 6e-06 Identities = 48/172 (27%), Positives = 70/172 (40%), Gaps = 18/172 (10%) Query: 351 TLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDW 409 TLR H + A+ W D RLL S DG L IW PL+ S+ V + Sbjct: 50 TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLR----SSWVMTCAY 105 Query: 410 CPWQSGVLAIGGGMKD----GRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQG 465 P SG GG+ + L + N S + P + +L + +I T G Sbjct: 106 AP--SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDS-QIVTSSG 162 Query: 466 TPKNDVTVWTCPTVSRS----GHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 +W T ++ GH G V+ L+LSPD S A D ++ +W+ Sbjct: 163 D--TTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWD 212 >gi|83779014 katanin p80 subunit B 1 [Homo sapiens] Length = 655 Score = 52.4 bits (124), Expect = 1e-06 Identities = 53/243 (21%), Positives = 95/243 (39%), Gaps = 22/243 (9%) Query: 274 NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--HFILSSG 331 N S V G LA G + V LW + + ++ GH S V ++ N ++ +G Sbjct: 22 NVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAG 81 Query: 332 SRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQ 391 S+ G + D+ A+ + HK +C+L + P G ++SG D + +W + Sbjct: 82 SQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW----DIRRK 137 Query: 392 GQPLKVITQSTAVKAMDWCP---WQSGVLAIGGGMKDGRLHILDINAGKSI-QTPSTNSQ 447 G + S AV+ + + P W + D + + D+ AGK + + P Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKW------LASAADDHTVKLWDLTAGKMMSEFPGHTGP 191 Query: 448 ICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS----RSGHRGRVLHLALSPDQTRVFSA 503 + + + P E G+ + W G G V + +PD ++S Sbjct: 192 VNVVEFHP--NEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249 Query: 504 AAD 506 D Sbjct: 250 CQD 252 Score = 42.0 bits (97), Expect = 0.001 Identities = 28/97 (28%), Positives = 44/97 (45%), Gaps = 2/97 (2%) Query: 284 EGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW--NHFILSSGSRLGRVYHHD 341 +G LA + V+LWD+ K + GH V + + N ++L+SGS + D Sbjct: 158 DGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217 Query: 342 VRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGL 378 + Q V ++ ++PDG L SGC D L Sbjct: 218 LEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSL 254 Score = 40.4 bits (93), Expect = 0.004 Identities = 36/152 (23%), Positives = 67/152 (44%), Gaps = 14/152 (9%) Query: 367 GRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDG 426 GRLL++G D + +W + +P +++ + ++ + I G + G Sbjct: 33 GRLLATGGDDCRVNLW-------SINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSG 85 Query: 427 RLHILDINAGKSIQT-PSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCP----TVSR 481 + + D+ A K ++T + ICSL + P + +A+G + ++ +W Sbjct: 86 SIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASG--SQDTNIKLWDIRRKGCVFRY 143 Query: 482 SGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 GH V L SPD + SAA D T +W+ Sbjct: 144 RGHSQAVRCLRFSPDGKWLASAADDHTVKLWD 175 >gi|157739942 gemin 5 [Homo sapiens] Length = 1508 Score = 52.4 bits (124), Expect = 1e-06 Identities = 30/129 (23%), Positives = 61/129 (47%), Gaps = 24/129 (18%) Query: 277 SSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNH---------FI 327 + +SW +G +A+G +G ++++ + K + + H +V +SW+H ++ Sbjct: 540 TEISWKADGKIMALGNEDGSIEIFQIPNLKLICTIQQHHKLVNTISWHHEHGSQPELSYL 599 Query: 328 LSSGSRLGRVYHHD------------VRVAQHHVGTLRHKQAVCALKWSP--DGRLLSSG 373 ++SGS +Y H+ V + + + H + ++ WSP DGRL+S+ Sbjct: 600 MASGSNNAVIYVHNLKTVIESSPESPVTITEPYRTLSGHTAKITSVAWSPHHDGRLVSAS 659 Query: 374 CSDGLLTIW 382 DG +W Sbjct: 660 -YDGTAQVW 667 Score = 48.1 bits (113), Expect = 2e-05 Identities = 72/304 (23%), Positives = 126/304 (41%), Gaps = 65/304 (21%) Query: 245 VAIALGSA-VYIWNG---ENHNGIENIDLSLTCNYISSVSW--IKEGTCLAVGTSEGEVQ 298 +AI +G + +WN +N+ ++N + ++++ W KEG CLA GT +G+V Sbjct: 395 LAIGVGDGMIRVWNTLSIKNNYDVKNFWQGVKSK-VTALCWHPTKEG-CLAFGTDDGKVG 452 Query: 299 LWDVVTKKRLR-NMLGHLSVVGALSWN---------------HFILSSGSRLGRVYHH-- 340 L+D + K + + H V L+W L S G V H Sbjct: 453 LYDTYSNKPPQISSTYHKKTVYTLAWGPPVPPMSLGGEGDRPSLALYSCGGEGIVLQHNP 512 Query: 341 --------DVRVAQHHVGTLRHKQAV-CALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQ 391 D+ ++++K V + W DG++++ G DG + I+ Q Sbjct: 513 WKLSGEAFDINKLIRDTNSIKYKLPVHTEISWKADGKIMALGNEDGSIEIF--------Q 564 Query: 392 GQPLKVI-TQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICS 450 LK+I T K ++ W H + + S N + Sbjct: 565 IPNLKLICTIQQHHKLVNTISWH-------------HEHGSQPELSYLMASGSNN----A 607 Query: 451 LIWLPKTKEIATGQGTPKNDVTVWTCPTVSRSGHRGRVLHLALSPDQT-RVFSAAADGTA 509 +I++ K + + +P++ VT+ T P + SGH ++ +A SP R+ SA+ DGTA Sbjct: 608 VIYVHNLKTVI--ESSPESPVTI-TEPYRTLSGHTAKITSVAWSPHHDGRLVSASYDGTA 664 Query: 510 SVWN 513 VW+ Sbjct: 665 QVWD 668 Score = 33.1 bits (74), Expect = 0.62 Identities = 43/196 (21%), Positives = 76/196 (38%), Gaps = 30/196 (15%) Query: 289 AVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN---HFILSSGSRLGRV--YHHDVR 343 A + +G V++WDV TK + H + L W+ ++ SG G V Y + Sbjct: 83 ATSSDDGTVKIWDVETKTVVTEHALHQHTISTLHWSPRVKDLIVSGDEKGVVFCYWFNRN 142 Query: 344 VAQHHVGTLRHKQAVCALKWSPDGR-LLSSGCSDGLLTIWPHDPGASAQGQPL-KVITQS 401 +QH + + L SP L++ G DG++ I S +G+ + ++ Sbjct: 143 DSQH---LFIEPRTIFCLTCSPHHEDLVAIGYKDGIVVI----IDISKKGEVIHRLRGHD 195 Query: 402 TAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGK-SIQTPSTNSQICSLIWLPKTKEI 460 + ++ WCP L IN + S + TN ++ P TK Sbjct: 196 DEIHSIAWCPLPGE-------------DCLSINQEETSEEAEITNGN--AVAQAPVTKGC 240 Query: 461 ATGQGTPKNDVTVWTC 476 G+ + +W+C Sbjct: 241 YLATGSKDQTIRIWSC 256 Score = 29.3 bits (64), Expect = 9.0 Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 1/50 (2%) Query: 276 ISSVSWIKEGTCLAVGTS-EGEVQLWDVVTKKRLRNMLGHLSVVGALSWN 324 I+SV+W V S +G Q+WD + ++ L N GH + ++W+ Sbjct: 642 ITSVAWSPHHDGRLVSASYDGTAQVWDALREEPLCNFRGHRGRLLCVAWS 691 >gi|113865883 WD repeat domain 38 [Homo sapiens] Length = 314 Score = 52.4 bits (124), Expect = 1e-06 Identities = 71/326 (21%), Positives = 119/326 (36%), Gaps = 84/326 (25%) Query: 199 VRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWSFQNLVAIALGSAVYIWNG 258 VR F + G++N S P+ ++ +TG + + W + S +W Sbjct: 11 VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGC---VYGWETR--------SGQLLWRL 59 Query: 259 ENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVV 318 H G + + +G A + + V+LWDV K LR + GH V Sbjct: 60 GGHTGP-----------VKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSV 108 Query: 319 GALSW--NHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSD 376 +S+ + L+SG RV DV+ Q + H+ ++ + +SP L++G D Sbjct: 109 ETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWD 168 Query: 377 GLLTIWPHDPGASAQGQPLKVITQSTAVKAMD--------WCPWQSGVLAIGGGMKDGRL 428 + IW L+++T + + +A++ C SG+LA G D + Sbjct: 169 STVHIW-----------DLRMVTPAVSHQALEGHSANISCLCYSASGLLA--SGSWDKTI 215 Query: 429 HILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVSRSGHRGRV 488 H IW P T + + GH V Sbjct: 216 H----------------------IWKPTTSSL-----------------LIQLKGHVTWV 236 Query: 489 LHLALSPDQTRVFSAAADGTASVWNC 514 +A SPD+ + SA VW+C Sbjct: 237 KSIAFSPDELWLASAGYSRMVKVWDC 262 Score = 45.1 bits (105), Expect = 2e-04 Identities = 47/171 (27%), Positives = 81/171 (47%), Gaps = 13/171 (7%) Query: 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFI--LSSGSR 333 + +VS+ + LA G + V LWDV + + LR ++GH + + ++ + L++GS Sbjct: 108 VETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW 167 Query: 334 LGRVYHHDVRV---AQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASA 390 V+ D+R+ A H H + L +S G LL+SG D + IW P S+ Sbjct: 168 DSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIW--KPTTSS 224 Query: 391 QGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQT 441 LK T VK++ + P + + + G + + D N GK ++T Sbjct: 225 LLIQLK--GHVTWVKSIAFSPDELWLASAG---YSRMVKVWDCNTGKCLET 270 >gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens] Length = 1298 Score = 52.0 bits (123), Expect = 1e-06 Identities = 61/253 (24%), Positives = 106/253 (41%), Gaps = 25/253 (9%) Query: 276 ISSVSWIKEG-TCLAVGTSEGEVQLWDVVTKKRLRNMLGH-LSVVGALSWNHFILSSGSR 333 I S+SW G C+A GTS +W+V K ++ H + + ++W+H R Sbjct: 415 IYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSH---KDSKR 471 Query: 334 LGRVYHHDVRVAQHHVGTLRHK----QAVCALKWSPDGR-LLSSGCSDGLLTIWPHDPGA 388 + + + G + HK AV WS + + ++++GC D + ++ A Sbjct: 472 IATCSSDGFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVY---YVA 528 Query: 389 SAQGQPLKVITQSTA-VKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTN-S 446 ++ QPLKV + TA V + W P + G+L G DG + I D I + + + Sbjct: 529 TSSDQPLKVFSGHTAKVFHVKWSPLREGILC--SGSDDGTVRIWDYTQDACINILNGHTA 586 Query: 447 QICSLIWLPKTKEIATGQGTPKNDVTVW-----TCPTVSRSGHRGRVLHLALSPDQT-RV 500 + L+W + + G+ + VW TC H V L P + + Sbjct: 587 PVRGLMWNTEIPYLLI-SGSWDYTIKVWDTREGTCVDTVYD-HGADVYGLTCHPSRPFTM 644 Query: 501 FSAAADGTASVWN 513 S + D T +W+ Sbjct: 645 ASCSRDSTVRLWS 657 Score = 33.1 bits (74), Expect = 0.62 Identities = 44/199 (22%), Positives = 86/199 (43%), Gaps = 25/199 (12%) Query: 276 ISSVSWIKEGTCL-AVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW---NHFILSSG 331 I+++SW L A G+++ V +W+V +K + + + +LSW +++ Sbjct: 62 ITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVAFV 121 Query: 332 SRLGRVYHHDVRVAQHHVGTLRHKQA------VCALKWSPDGR-LLSSGCSDGLLTIWPH 384 S G ++ ++ G + HK A +C +W + + G DG L+I+ Sbjct: 122 SHRGPLFIW--TISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSIF-- 177 Query: 385 DPGASAQ-----GQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSI 439 PG Q + L+ + V A++W P + L + + G + ++D + I Sbjct: 178 HPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLV-VNLHYG-IRLVDSESLSCI 235 Query: 440 QT---PSTNSQICSLIWLP 455 T PS + + L W+P Sbjct: 236 TTFNLPSAAASVQCLAWVP 254 >gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens] Length = 1322 Score = 52.0 bits (123), Expect = 1e-06 Identities = 61/253 (24%), Positives = 106/253 (41%), Gaps = 25/253 (9%) Query: 276 ISSVSWIKEG-TCLAVGTSEGEVQLWDVVTKKRLRNMLGH-LSVVGALSWNHFILSSGSR 333 I S+SW G C+A GTS +W+V K ++ H + + ++W+H R Sbjct: 439 IYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSH---KDSKR 495 Query: 334 LGRVYHHDVRVAQHHVGTLRHK----QAVCALKWSPDGR-LLSSGCSDGLLTIWPHDPGA 388 + + + G + HK AV WS + + ++++GC D + ++ A Sbjct: 496 IATCSSDGFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVY---YVA 552 Query: 389 SAQGQPLKVITQSTA-VKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTN-S 446 ++ QPLKV + TA V + W P + G+L G DG + I D I + + + Sbjct: 553 TSSDQPLKVFSGHTAKVFHVKWSPLREGILC--SGSDDGTVRIWDYTQDACINILNGHTA 610 Query: 447 QICSLIWLPKTKEIATGQGTPKNDVTVW-----TCPTVSRSGHRGRVLHLALSPDQT-RV 500 + L+W + + G+ + VW TC H V L P + + Sbjct: 611 PVRGLMWNTEIPYLLI-SGSWDYTIKVWDTREGTCVDTVYD-HGADVYGLTCHPSRPFTM 668 Query: 501 FSAAADGTASVWN 513 S + D T +W+ Sbjct: 669 ASCSRDSTVRLWS 681 Score = 33.1 bits (74), Expect = 0.62 Identities = 44/199 (22%), Positives = 86/199 (43%), Gaps = 25/199 (12%) Query: 276 ISSVSWIKEGTCL-AVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW---NHFILSSG 331 I+++SW L A G+++ V +W+V +K + + + +LSW +++ Sbjct: 86 ITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVAFV 145 Query: 332 SRLGRVYHHDVRVAQHHVGTLRHKQA------VCALKWSPDGR-LLSSGCSDGLLTIWPH 384 S G ++ ++ G + HK A +C +W + + G DG L+I+ Sbjct: 146 SHRGPLFIW--TISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSIF-- 201 Query: 385 DPGASAQ-----GQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSI 439 PG Q + L+ + V A++W P + L + + G + ++D + I Sbjct: 202 HPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLV-VNLHYG-IRLVDSESLSCI 259 Query: 440 QT---PSTNSQICSLIWLP 455 T PS + + L W+P Sbjct: 260 TTFNLPSAAASVQCLAWVP 278 >gi|19913367 transducin beta-like 1Y [Homo sapiens] Length = 522 Score = 52.0 bits (123), Expect = 1e-06 Identities = 90/424 (21%), Positives = 157/424 (37%), Gaps = 82/424 (19%) Query: 156 SVASKGQKCLKQLFVTQNVVQQANGKMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDS 215 + A++ K +T + Q N + E G ++G + + H K D Sbjct: 110 AAATEASAMAKAATMTPAAISQQNPP----KNREATVNGEENGAHEINNHSKPMEIDGDV 165 Query: 216 ILQPEVKIHITGLRNDYYLNILDWS-FQNLVAIALG-SAVYIWN-GENHNGIENIDLSLT 272 + P + G ++ + I W+ +L+A G S IWN EN NG + Sbjct: 166 EIPPNKATVLRGHESEVF--ICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 223 Query: 273 C-----------NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLG-HLSVVGA 320 C ++S+ W +GT LA+G+ +G ++W L + LG H + A Sbjct: 224 CIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFA 281 Query: 321 LSWN---HFILSSG---------SRLGRV-----YH------------------------ 339 L WN +++LS+G + G +H Sbjct: 282 LKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCI 341 Query: 340 HDVRVA-QHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKV 397 H R+ H V T + H V A+KW P G LL+S D L IW A + Sbjct: 342 HVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVH----DL 397 Query: 398 ITQSTAVKAMDWCPW------QSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQ-ICS 450 S + + W P + + + D + + D+ G T + + + S Sbjct: 398 QAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYS 457 Query: 451 LIWLPKTKEIATGQGTPKNDVTVWTCPT---VSRSGHRGRVLHLALSPDQTRVFSAAADG 507 + + P K +A+ G+ V +W + V G + + + +V ++A+DG Sbjct: 458 VAFSPDGKYLAS--GSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDG 515 Query: 508 TASV 511 + V Sbjct: 516 SVCV 519 Score = 45.4 bits (106), Expect = 1e-04 Identities = 36/171 (21%), Positives = 71/171 (41%), Gaps = 19/171 (11%) Query: 274 NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--------- 324 N ++++ W G LA + + +++W + + ++ H + + W+ Sbjct: 360 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNP 419 Query: 325 --HFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382 +L+S S V DV ++H++ V ++ +SPDG+ L+SG D + IW Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479 Query: 383 PHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDI 433 G+ Q T + C W + +G DG + +LD+ Sbjct: 480 NTQSGSLVHSY------QGTG-GIFEVC-WNARGDKVGASASDGSVCVLDL 522 Score = 41.6 bits (96), Expect = 0.002 Identities = 48/199 (24%), Positives = 75/199 (37%), Gaps = 25/199 (12%) Query: 323 WNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382 WN S+G V H +R H V + + V +L W+ DG LL+ G DG IW Sbjct: 206 WNLNENSNGGSTQLVLRHCIREGGHDVPS---NKDVTSLDWNSDGTLLAMGSYDGFARIW 262 Query: 383 PHDPG-ASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQT 441 + AS GQ + A+ W + VL+ G D I D + G++ Q Sbjct: 263 TENGNLASTLGQ------HKGPIFALKWNKKGNYVLSAG---VDKTTIIWDAHTGEAKQQ 313 Query: 442 -PSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTC------PTVSRSGHRGRVLHLALS 494 P ++ + W + D+ + C P + GH V + Sbjct: 314 FPFHSAPALDVDWQNNMTFASC-----STDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWD 368 Query: 495 PDQTRVFSAAADGTASVWN 513 P + S + D T +W+ Sbjct: 369 PSGMLLASCSDDMTLKIWS 387 >gi|19913365 transducin beta-like 1Y [Homo sapiens] Length = 522 Score = 52.0 bits (123), Expect = 1e-06 Identities = 90/424 (21%), Positives = 157/424 (37%), Gaps = 82/424 (19%) Query: 156 SVASKGQKCLKQLFVTQNVVQQANGKMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDS 215 + A++ K +T + Q N + E G ++G + + H K D Sbjct: 110 AAATEASAMAKAATMTPAAISQQNPP----KNREATVNGEENGAHEINNHSKPMEIDGDV 165 Query: 216 ILQPEVKIHITGLRNDYYLNILDWS-FQNLVAIALG-SAVYIWN-GENHNGIENIDLSLT 272 + P + G ++ + I W+ +L+A G S IWN EN NG + Sbjct: 166 EIPPNKATVLRGHESEVF--ICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 223 Query: 273 C-----------NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLG-HLSVVGA 320 C ++S+ W +GT LA+G+ +G ++W L + LG H + A Sbjct: 224 CIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFA 281 Query: 321 LSWN---HFILSSG---------SRLGRV-----YH------------------------ 339 L WN +++LS+G + G +H Sbjct: 282 LKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCI 341 Query: 340 HDVRVA-QHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKV 397 H R+ H V T + H V A+KW P G LL+S D L IW A + Sbjct: 342 HVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVH----DL 397 Query: 398 ITQSTAVKAMDWCPW------QSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQ-ICS 450 S + + W P + + + D + + D+ G T + + + S Sbjct: 398 QAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYS 457 Query: 451 LIWLPKTKEIATGQGTPKNDVTVWTCPT---VSRSGHRGRVLHLALSPDQTRVFSAAADG 507 + + P K +A+ G+ V +W + V G + + + +V ++A+DG Sbjct: 458 VAFSPDGKYLAS--GSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDG 515 Query: 508 TASV 511 + V Sbjct: 516 SVCV 519 Score = 45.4 bits (106), Expect = 1e-04 Identities = 36/171 (21%), Positives = 71/171 (41%), Gaps = 19/171 (11%) Query: 274 NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--------- 324 N ++++ W G LA + + +++W + + ++ H + + W+ Sbjct: 360 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNP 419 Query: 325 --HFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382 +L+S S V DV ++H++ V ++ +SPDG+ L+SG D + IW Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479 Query: 383 PHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDI 433 G+ Q T + C W + +G DG + +LD+ Sbjct: 480 NTQSGSLVHSY------QGTG-GIFEVC-WNARGDKVGASASDGSVCVLDL 522 Score = 41.6 bits (96), Expect = 0.002 Identities = 48/199 (24%), Positives = 75/199 (37%), Gaps = 25/199 (12%) Query: 323 WNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382 WN S+G V H +R H V + + V +L W+ DG LL+ G DG IW Sbjct: 206 WNLNENSNGGSTQLVLRHCIREGGHDVPS---NKDVTSLDWNSDGTLLAMGSYDGFARIW 262 Query: 383 PHDPG-ASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQT 441 + AS GQ + A+ W + VL+ G D I D + G++ Q Sbjct: 263 TENGNLASTLGQ------HKGPIFALKWNKKGNYVLSAG---VDKTTIIWDAHTGEAKQQ 313 Query: 442 -PSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTC------PTVSRSGHRGRVLHLALS 494 P ++ + W + D+ + C P + GH V + Sbjct: 314 FPFHSAPALDVDWQNNMTFASC-----STDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWD 368 Query: 495 PDQTRVFSAAADGTASVWN 513 P + S + D T +W+ Sbjct: 369 PSGMLLASCSDDMTLKIWS 387 >gi|15150805 transducin beta-like 1Y [Homo sapiens] Length = 522 Score = 52.0 bits (123), Expect = 1e-06 Identities = 90/424 (21%), Positives = 157/424 (37%), Gaps = 82/424 (19%) Query: 156 SVASKGQKCLKQLFVTQNVVQQANGKMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDS 215 + A++ K +T + Q N + E G ++G + + H K D Sbjct: 110 AAATEASAMAKAATMTPAAISQQNPP----KNREATVNGEENGAHEINNHSKPMEIDGDV 165 Query: 216 ILQPEVKIHITGLRNDYYLNILDWS-FQNLVAIALG-SAVYIWN-GENHNGIENIDLSLT 272 + P + G ++ + I W+ +L+A G S IWN EN NG + Sbjct: 166 EIPPNKATVLRGHESEVF--ICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 223 Query: 273 C-----------NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLG-HLSVVGA 320 C ++S+ W +GT LA+G+ +G ++W L + LG H + A Sbjct: 224 CIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFA 281 Query: 321 LSWN---HFILSSG---------SRLGRV-----YH------------------------ 339 L WN +++LS+G + G +H Sbjct: 282 LKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCI 341 Query: 340 HDVRVA-QHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKV 397 H R+ H V T + H V A+KW P G LL+S D L IW A + Sbjct: 342 HVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVH----DL 397 Query: 398 ITQSTAVKAMDWCPW------QSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQ-ICS 450 S + + W P + + + D + + D+ G T + + + S Sbjct: 398 QAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYS 457 Query: 451 LIWLPKTKEIATGQGTPKNDVTVWTCPT---VSRSGHRGRVLHLALSPDQTRVFSAAADG 507 + + P K +A+ G+ V +W + V G + + + +V ++A+DG Sbjct: 458 VAFSPDGKYLAS--GSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDG 515 Query: 508 TASV 511 + V Sbjct: 516 SVCV 519 Score = 45.4 bits (106), Expect = 1e-04 Identities = 36/171 (21%), Positives = 71/171 (41%), Gaps = 19/171 (11%) Query: 274 NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--------- 324 N ++++ W G LA + + +++W + + ++ H + + W+ Sbjct: 360 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNP 419 Query: 325 --HFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382 +L+S S V DV ++H++ V ++ +SPDG+ L+SG D + IW Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479 Query: 383 PHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDI 433 G+ Q T + C W + +G DG + +LD+ Sbjct: 480 NTQSGSLVHSY------QGTG-GIFEVC-WNARGDKVGASASDGSVCVLDL 522 Score = 41.6 bits (96), Expect = 0.002 Identities = 48/199 (24%), Positives = 75/199 (37%), Gaps = 25/199 (12%) Query: 323 WNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382 WN S+G V H +R H V + + V +L W+ DG LL+ G DG IW Sbjct: 206 WNLNENSNGGSTQLVLRHCIREGGHDVPS---NKDVTSLDWNSDGTLLAMGSYDGFARIW 262 Query: 383 PHDPG-ASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQT 441 + AS GQ + A+ W + VL+ G D I D + G++ Q Sbjct: 263 TENGNLASTLGQ------HKGPIFALKWNKKGNYVLSAG---VDKTTIIWDAHTGEAKQQ 313 Query: 442 -PSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTC------PTVSRSGHRGRVLHLALS 494 P ++ + W + D+ + C P + GH V + Sbjct: 314 FPFHSAPALDVDWQNNMTFASC-----STDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWD 368 Query: 495 PDQTRVFSAAADGTASVWN 513 P + S + D T +W+ Sbjct: 369 PSGMLLASCSDDMTLKIWS 387 >gi|45594312 TNF receptor-associated factor 7 [Homo sapiens] Length = 670 Score = 51.2 bits (121), Expect = 2e-06 Identities = 67/251 (26%), Positives = 103/251 (41%), Gaps = 51/251 (20%) Query: 285 GTCLAVGTSEGEVQLWDVVTKKRLRNML-GHLSVVGALSWNHFILSSGSRLGRVYHHDVR 343 G L G+S+ +++WD T + + L GH +V AL L SGS + D++ Sbjct: 408 GDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQ 467 Query: 344 VAQHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQST 402 Q V T+R H VC L S + +L SG S + +W G LK+ + T Sbjct: 468 NLQK-VNTIRAHDNPVCTLVSSHN--VLFSG-SLKAIKVW------DIVGTELKLKKELT 517 Query: 403 AVKAMDWCPWQSGVLAIGGGMKDGR--------------LHILDINAGKSIQTPSTNSQI 448 + W ++A + G +H+L + G TN I Sbjct: 518 GLNH-----WVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHI 572 Query: 449 CSLIWLPKTKEIATGQGTPKNDVTVWTCPTVSR----SGHRGRVLHLAL--SPDQTRVFS 502 GT +N + VW + + +GH G V LA+ +PDQT+VFS Sbjct: 573 VC--------------GTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFS 618 Query: 503 AAADGTASVWN 513 A+ D + VW+ Sbjct: 619 ASYDRSLRVWS 629 Score = 40.8 bits (94), Expect = 0.003 Identities = 31/101 (30%), Positives = 50/101 (49%), Gaps = 10/101 (9%) Query: 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALS------WNHFILSSGSRLGRVYHHD 341 + GT E + +WD+ +K+++R + GH+ V AL+ +S R RV+ D Sbjct: 572 IVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMD 631 Query: 342 VRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382 + + LRH+ +V AL S GRL SG D + +W Sbjct: 632 NMICTQTL--LRHQGSVTALAVS-RGRLF-SGAVDSTVKVW 668 >gi|41281447 intraflagellar transport 140 [Homo sapiens] Length = 1462 Score = 51.2 bits (121), Expect = 2e-06 Identities = 59/225 (26%), Positives = 87/225 (38%), Gaps = 52/225 (23%) Query: 318 VGALSWN--HFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCS 375 V +L W+ +L+ G G V + + + H L H + L+WSP G L SG Sbjct: 64 VASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHTMPLTHTADITVLRWSPSGNCLLSGDR 123 Query: 376 DGLLTIWPHDPGASAQGQPL------KVITQ--------------------STAVKAMDW 409 G+L +W D QG PL K +T S KA+D Sbjct: 124 LGVLLLWRLDQRGRVQGTPLLKHEYGKHLTHCIFRLPPPGEDLVQLAKAAVSGDEKALDM 183 Query: 410 CPWQ---SGVLAIGG---------GMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKT 457 W+ SG L G + DG +H +D GK+ Q S +S I L ++ K Sbjct: 184 FNWKKSSSGSLLKMGSHEGLLFFVSLMDGTVHYVD-EKGKTTQVVSADSTIQMLFYMEKR 242 Query: 458 KEIATGQGTPKNDVTVWTCP---------TVSRSGHRGRVLHLAL 493 + + T ++++T P V SG GR +AL Sbjct: 243 EALVV--VTENLRLSLYTVPPEGKAEEVMKVKLSGKTGRRADIAL 285 >gi|32189425 WD repeat domain 69 [Homo sapiens] Length = 415 Score = 50.8 bits (120), Expect = 3e-06 Identities = 51/235 (21%), Positives = 96/235 (40%), Gaps = 14/235 (5%) Query: 285 GTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--HFILSSGSRLGRVYHHDV 342 G +A G+ + +LW V T K GH + + LS+N ++++GS D+ Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206 Query: 343 RVAQHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQS 401 + + V TLR H + +L ++ G + +G D + +W D G + + ++ Sbjct: 207 QNGEE-VYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTG-----RKVNILIGH 260 Query: 402 TAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQT-PSTNSQICSLIWLPKTKEI 460 A + W ++ G D + D GK + T + +I + K I Sbjct: 261 CAEISSASFNWDCSLILTGS--MDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLI 318 Query: 461 ATGQ--GTPKNDVTVWTCPTVSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 AT GT + GH G + ++ +P + + ++D TA +W+ Sbjct: 319 ATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373 Score = 33.1 bits (74), Expect = 0.62 Identities = 43/216 (19%), Positives = 85/216 (39%), Gaps = 12/216 (5%) Query: 262 NGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGAL 321 NG E L I S+S+ G + G+ + V +WD T +++ ++GH + + + Sbjct: 208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSA 267 Query: 322 S--WNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLL 379 S W+ ++ +GS D + H + + G+L+++ +DG Sbjct: 268 SFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTA 327 Query: 380 TIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSI 439 I+ A+ + K+ + + + P + +L G D I D G+ + Sbjct: 328 RIF----SAATRKCIAKLEGHEGEISKISFNPQGNHLLT---GSSDKTARIWDAQTGQCL 380 Query: 440 QT-PSTNSQICSLIWLPKTKEIATGQGTPKNDVTVW 474 Q +I S + K + T G+ N +W Sbjct: 381 QVLEGHTDEIFSCAFNYKGNIVIT--GSKDNTCRIW 414 >gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo sapiens] Length = 589 Score = 49.3 bits (116), Expect = 8e-06 Identities = 48/228 (21%), Positives = 96/228 (42%), Gaps = 19/228 (8%) Query: 291 GTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVG 350 G+++ +++W+ T + + + GH S V + + + SGSR + D+ Q Sbjct: 319 GSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHV 378 Query: 351 TLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWC 410 + H AV +++ DGR + SG D ++ +W DP L+ T D Sbjct: 379 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVW--DPETETCLHTLQGHTNRVYSLQFD-- 432 Query: 411 PWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKND 470 G+ + G + D + + D+ G I T + + + S + L K+ G + Sbjct: 433 ----GIHVVSGSL-DTSIRVWDVETGNCIHTLTGHQSLTSGMEL---KDNILVSGNADST 484 Query: 471 VTVW-----TCPTVSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 V +W C + ++ + L ++ V +++ DGT +W+ Sbjct: 485 VKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWD 532 Score = 41.2 bits (95), Expect = 0.002 Identities = 34/144 (23%), Positives = 66/144 (45%), Gaps = 9/144 (6%) Query: 242 QNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWD 301 + +V+ A V +W+ E + L N + S+ + +G + G+ + +++WD Sbjct: 394 RRVVSGAYDFMVKVWDPETETCLHT--LQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 449 Query: 302 VVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVA---QHHVGTLRHKQAV 358 V T + + GH S+ + IL SG+ V D++ Q G +H+ AV Sbjct: 450 VETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV 509 Query: 359 CALKWSPDGRLLSSGCSDGLLTIW 382 L+++ + + SS DG + +W Sbjct: 510 TCLQFNKNFVITSS--DDGTVKLW 531 Score = 32.0 bits (71), Expect = 1.4 Identities = 30/124 (24%), Positives = 58/124 (46%), Gaps = 3/124 (2%) Query: 269 LSLTCNYISSVSWIK-EGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFI 327 L + ++++V ++ +G + G + V++WD T+ L + GH + V +L ++ Sbjct: 376 LHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH 435 Query: 328 LSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPG 387 + SGS + DV + + TL Q++ + D +L SG +D + IW G Sbjct: 436 VVSGSLDTSIRVWDVETG-NCIHTLTGHQSLTSGMELKD-NILVSGNADSTVKIWDIKTG 493 Query: 388 ASAQ 391 Q Sbjct: 494 QCLQ 497 >gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo sapiens] Length = 707 Score = 49.3 bits (116), Expect = 8e-06 Identities = 48/228 (21%), Positives = 96/228 (42%), Gaps = 19/228 (8%) Query: 291 GTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVG 350 G+++ +++W+ T + + + GH S V + + + SGSR + D+ Q Sbjct: 437 GSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHV 496 Query: 351 TLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWC 410 + H AV +++ DGR + SG D ++ +W DP L+ T D Sbjct: 497 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVW--DPETETCLHTLQGHTNRVYSLQFD-- 550 Query: 411 PWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKND 470 G+ + G + D + + D+ G I T + + + S + L K+ G + Sbjct: 551 ----GIHVVSGSL-DTSIRVWDVETGNCIHTLTGHQSLTSGMEL---KDNILVSGNADST 602 Query: 471 VTVW-----TCPTVSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 V +W C + ++ + L ++ V +++ DGT +W+ Sbjct: 603 VKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWD 650 Score = 41.2 bits (95), Expect = 0.002 Identities = 34/144 (23%), Positives = 66/144 (45%), Gaps = 9/144 (6%) Query: 242 QNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWD 301 + +V+ A V +W+ E + L N + S+ + +G + G+ + +++WD Sbjct: 512 RRVVSGAYDFMVKVWDPETETCLHT--LQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 567 Query: 302 VVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVA---QHHVGTLRHKQAV 358 V T + + GH S+ + IL SG+ V D++ Q G +H+ AV Sbjct: 568 VETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV 627 Query: 359 CALKWSPDGRLLSSGCSDGLLTIW 382 L+++ + + SS DG + +W Sbjct: 628 TCLQFNKNFVITSS--DDGTVKLW 649 Score = 32.0 bits (71), Expect = 1.4 Identities = 30/124 (24%), Positives = 58/124 (46%), Gaps = 3/124 (2%) Query: 269 LSLTCNYISSVSWIK-EGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFI 327 L + ++++V ++ +G + G + V++WD T+ L + GH + V +L ++ Sbjct: 494 LHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH 553 Query: 328 LSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPG 387 + SGS + DV + + TL Q++ + D +L SG +D + IW G Sbjct: 554 VVSGSLDTSIRVWDVETG-NCIHTLTGHQSLTSGMELKD-NILVSGNADSTVKIWDIKTG 611 Query: 388 ASAQ 391 Q Sbjct: 612 QCLQ 615 >gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo sapiens] Length = 627 Score = 49.3 bits (116), Expect = 8e-06 Identities = 48/228 (21%), Positives = 96/228 (42%), Gaps = 19/228 (8%) Query: 291 GTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVG 350 G+++ +++W+ T + + + GH S V + + + SGSR + D+ Q Sbjct: 357 GSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHV 416 Query: 351 TLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWC 410 + H AV +++ DGR + SG D ++ +W DP L+ T D Sbjct: 417 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVW--DPETETCLHTLQGHTNRVYSLQFD-- 470 Query: 411 PWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKND 470 G+ + G + D + + D+ G I T + + + S + L K+ G + Sbjct: 471 ----GIHVVSGSL-DTSIRVWDVETGNCIHTLTGHQSLTSGMEL---KDNILVSGNADST 522 Query: 471 VTVW-----TCPTVSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513 V +W C + ++ + L ++ V +++ DGT +W+ Sbjct: 523 VKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWD 570 Score = 41.2 bits (95), Expect = 0.002 Identities = 34/144 (23%), Positives = 66/144 (45%), Gaps = 9/144 (6%) Query: 242 QNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWD 301 + +V+ A V +W+ E + L N + S+ + +G + G+ + +++WD Sbjct: 432 RRVVSGAYDFMVKVWDPETETCLHT--LQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 487 Query: 302 VVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVA---QHHVGTLRHKQAV 358 V T + + GH S+ + IL SG+ V D++ Q G +H+ AV Sbjct: 488 VETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV 547 Query: 359 CALKWSPDGRLLSSGCSDGLLTIW 382 L+++ + + SS DG + +W Sbjct: 548 TCLQFNKNFVITSS--DDGTVKLW 569 Score = 32.0 bits (71), Expect = 1.4 Identities = 30/124 (24%), Positives = 58/124 (46%), Gaps = 3/124 (2%) Query: 269 LSLTCNYISSVSWIK-EGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFI 327 L + ++++V ++ +G + G + V++WD T+ L + GH + V +L ++ Sbjct: 414 LHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH 473 Query: 328 LSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPG 387 + SGS + DV + + TL Q++ + D +L SG +D + IW G Sbjct: 474 VVSGSLDTSIRVWDVETG-NCIHTLTGHQSLTSGMELKD-NILVSGNADSTVKIWDIKTG 531 Query: 388 ASAQ 391 Q Sbjct: 532 QCLQ 535 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.129 0.400 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 20,393,068 Number of Sequences: 37866 Number of extensions: 896183 Number of successful extensions: 3932 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 106 Number of HSP's successfully gapped in prelim test: 125 Number of HSP's that attempted gapping in prelim test: 2841 Number of HSP's gapped (non-prelim): 937 length of query: 515 length of database: 18,247,518 effective HSP length: 107 effective length of query: 408 effective length of database: 14,195,856 effective search space: 5791909248 effective search space used: 5791909248 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.