Guide to the Human Genome
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Search of human proteins with 22749275

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22749275 CDC20 cell division cycle 20 homolog B isoform 1
[Homo sapiens]
         (515 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22749275 CDC20 cell division cycle 20 homolog B isoform 1 [Ho...  1055   0.0  
gi|224593764 CDC20 cell division cycle 20 homolog B isoform 2 [H...   936   0.0  
gi|118402582 cell division cycle 20 [Homo sapiens]                    306   2e-83
gi|209969680 Fzr1 protein isoform 1 [Homo sapiens]                    208   8e-54
gi|33620742 Fzr1 protein isoform 2 [Homo sapiens]                     208   8e-54
gi|209969678 Fzr1 protein isoform 3 [Homo sapiens]                    175   1e-43
gi|16554629 WD repeat domain 5 [Homo sapiens]                          67   5e-11
gi|16554627 WD repeat domain 5 [Homo sapiens]                          67   5e-11
gi|23199987 WD repeat domain 5B [Homo sapiens]                         63   6e-10
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            62   1e-09
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [...    61   3e-09
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [...    59   1e-08
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    55   1e-07
gi|62234438 Notchless gene homolog isoform b [Homo sapiens]            55   1e-07
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     54   3e-07
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [...    54   4e-07
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     52   1e-06
gi|157739942 gemin 5 [Homo sapiens]                                    52   1e-06
gi|113865883 WD repeat domain 38 [Homo sapiens]                        52   1e-06
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]               52   1e-06
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]               52   1e-06
gi|19913367 transducin beta-like 1Y [Homo sapiens]                     52   1e-06
gi|19913365 transducin beta-like 1Y [Homo sapiens]                     52   1e-06
gi|15150805 transducin beta-like 1Y [Homo sapiens]                     52   1e-06
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]            51   2e-06
gi|41281447 intraflagellar transport 140 [Homo sapiens]                51   2e-06
gi|32189425 WD repeat domain 69 [Homo sapiens]                         51   3e-06
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...    49   8e-06
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...    49   8e-06
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...    49   8e-06

>gi|22749275 CDC20 cell division cycle 20 homolog B isoform 1 [Homo
           sapiens]
          Length = 515

 Score = 1055 bits (2728), Expect = 0.0
 Identities = 515/515 (100%), Positives = 515/515 (100%)

Query: 1   MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAK 60
           MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAK
Sbjct: 1   MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAK 60

Query: 61  RLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGS 120
           RLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGS
Sbjct: 61  RLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGS 120

Query: 121 CKEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANG 180
           CKEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANG
Sbjct: 121 CKEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANG 180

Query: 181 KMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWS 240
           KMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWS
Sbjct: 181 KMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWS 240

Query: 241 FQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLW 300
           FQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLW
Sbjct: 241 FQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLW 300

Query: 301 DVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCA 360
           DVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCA
Sbjct: 301 DVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCA 360

Query: 361 LKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIG 420
           LKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIG
Sbjct: 361 LKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIG 420

Query: 421 GGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS 480
           GGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS
Sbjct: 421 GGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS 480

Query: 481 RSGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 515
           RSGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY
Sbjct: 481 RSGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 515


>gi|224593764 CDC20 cell division cycle 20 homolog B isoform 2 [Homo
           sapiens]
          Length = 477

 Score =  936 bits (2419), Expect = 0.0
 Identities = 472/519 (90%), Positives = 472/519 (90%), Gaps = 46/519 (8%)

Query: 1   MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAK 60
           MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAK
Sbjct: 1   MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAK 60

Query: 61  RLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGS 120
           RLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGS
Sbjct: 61  RLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGS 120

Query: 121 CKEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANG 180
            KEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANG
Sbjct: 121 RKEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANG 180

Query: 181 KMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWS 240
           KMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWS
Sbjct: 181 KMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWS 240

Query: 241 FQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLW 300
           FQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLW
Sbjct: 241 FQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLW 300

Query: 301 DVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCA 360
           DVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCA
Sbjct: 301 DVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCA 360

Query: 361 LKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIG 420
           LKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVK               
Sbjct: 361 LKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVK--------------- 405

Query: 421 GGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS 480
                                      ICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS
Sbjct: 406 ---------------------------ICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS 438

Query: 481 RS----GHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 515
           RS    GHRGRVLHLALSPDQTRVFSAAADGTASVWNCY
Sbjct: 439 RSGGFFGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 477


>gi|118402582 cell division cycle 20 [Homo sapiens]
          Length = 499

 Score =  306 bits (785), Expect = 2e-83
 Identities = 147/294 (50%), Positives = 199/294 (67%), Gaps = 7/294 (2%)

Query: 228 LRNDYYLNILDWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTC 287
           +RNDYYLN++DWS  N++A+AL ++VY+W+  + + ++ + +     YISSV+WIKEG  
Sbjct: 181 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY 240

Query: 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQH 347
           LAVGTS  EVQLWDV  +KRLRNM  H + VG+LSWN +ILSSGSR G ++HHDVRVA+H
Sbjct: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH 300

Query: 348 HVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQ-STAVK 405
           HV TL  H Q VC L+W+PDGR L+SG +D L+ +WP  PG      PL+  TQ   AVK
Sbjct: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG-WVPLQTFTQHQGAVK 359

Query: 406 AMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQG 465
           A+ WCPWQS VLA GGG  D  + I ++ +G  +     +SQ+CS++W P  KE+ +G G
Sbjct: 360 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHG 419

Query: 466 TPKNDVTVWTCPTVSR----SGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 515
             +N + +W  PT+++     GH  RVL L +SPD   V SAAAD T  +W C+
Sbjct: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473


>gi|209969680 Fzr1 protein isoform 1 [Homo sapiens]
          Length = 496

 Score =  208 bits (530), Expect = 8e-54
 Identities = 110/294 (37%), Positives = 165/294 (56%), Gaps = 10/294 (3%)

Query: 228 LRNDYYLNILDWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTC 287
           L++D+YLN++DWS  N++++ LG+ VY+W+          DLS+  + ++SV W + G  
Sbjct: 184 LQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNL 243

Query: 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRV--A 345
           +AVGT +G VQ+WD    K+L  + GH + VGAL+WN   LSSGSR   +   D+R    
Sbjct: 244 VAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPL 303

Query: 346 QHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVK 405
           Q       H+Q VC LKWS D +LL+SG +D  L +W H   +  Q    +      AVK
Sbjct: 304 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ----QYTEHLAAVK 359

Query: 406 AMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQG 465
           A+ W P Q G+LA GGG  D  +   +   G+ +Q   T SQ+C+L W     E+ +  G
Sbjct: 360 AIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHG 419

Query: 466 TPKNDVTVWTCPTVSR----SGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 515
             +N + VW  P++++    +GH  RVL+LA+SPD   + + A D T   WN +
Sbjct: 420 YSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVF 473


>gi|33620742 Fzr1 protein isoform 2 [Homo sapiens]
          Length = 493

 Score =  208 bits (530), Expect = 8e-54
 Identities = 110/294 (37%), Positives = 165/294 (56%), Gaps = 10/294 (3%)

Query: 228 LRNDYYLNILDWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTC 287
           L++D+YLN++DWS  N++++ LG+ VY+W+          DLS+  + ++SV W + G  
Sbjct: 184 LQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNL 243

Query: 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRV--A 345
           +AVGT +G VQ+WD    K+L  + GH + VGAL+WN   LSSGSR   +   D+R    
Sbjct: 244 VAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPL 303

Query: 346 QHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVK 405
           Q       H+Q VC LKWS D +LL+SG +D  L +W H   +  Q    +      AVK
Sbjct: 304 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ----QYTEHLAAVK 359

Query: 406 AMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQG 465
           A+ W P Q G+LA GGG  D  +   +   G+ +Q   T SQ+C+L W     E+ +  G
Sbjct: 360 AIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHG 419

Query: 466 TPKNDVTVWTCPTVSR----SGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 515
             +N + VW  P++++    +GH  RVL+LA+SPD   + + A D T   WN +
Sbjct: 420 YSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVF 473


>gi|209969678 Fzr1 protein isoform 3 [Homo sapiens]
          Length = 404

 Score =  175 bits (443), Expect = 1e-43
 Identities = 96/254 (37%), Positives = 139/254 (54%), Gaps = 10/254 (3%)

Query: 268 DLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFI 327
           DLS+  + ++SV W + G  +AVGT +G VQ+WD    K+L  + GH + VGAL+WN   
Sbjct: 135 DLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ 194

Query: 328 LSSGSRLGRVYHHDVRV--AQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHD 385
           LSSGSR   +   D+R    Q       H+Q VC LKWS D +LL+SG +D  L +W H 
Sbjct: 195 LSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHS 254

Query: 386 PGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTN 445
             +  Q    +      AVKA+ W P Q G+LA GGG  D  +   +   G+ +Q   T 
Sbjct: 255 SLSPVQ----QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTG 310

Query: 446 SQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVSR----SGHRGRVLHLALSPDQTRVF 501
           SQ+C+L W     E+ +  G  +N + VW  P++++    +GH  RVL+LA+SPD   + 
Sbjct: 311 SQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIV 370

Query: 502 SAAADGTASVWNCY 515
           + A D T   WN +
Sbjct: 371 TGAGDETLRFWNVF 384


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 66/249 (26%), Positives = 105/249 (42%), Gaps = 20/249 (8%)

Query: 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--HFILSSGSR 333
           IS V+W  +   L   + +  +++WDV + K L+ + GH + V   ++N    ++ SGS 
Sbjct: 90  ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149

Query: 334 LGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQ 393
              V   DV+  +       H   V A+ ++ DG L+ S   DGL  IW      +A GQ
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD-----TASGQ 204

Query: 394 PLKVI--TQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPS--TNSQIC 449
            LK +    +  V  + + P    +LA      D  L + D + GK ++T +   N + C
Sbjct: 205 CLKTLIDDDNPPVSFVKFSPNGKYILA---ATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261

Query: 450 SLIWLPKTKEIATGQGTPKNDVTVWTCPT----VSRSGHRGRVLHLALSPDQTRVFSAAA 505
                  T       G+  N V +W   T        GH   V+  A  P +  + SAA 
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321

Query: 506 --DGTASVW 512
             D T  +W
Sbjct: 322 ENDKTIKLW 330



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 14/165 (8%)

Query: 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQ 413
           H +AV ++K+SP+G  L+S  +D L+ IW    G   +       T S     +    W 
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK-------TISGHKLGISDVAWS 96

Query: 414 SGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQ-ICSLIWLPKTKEIATGQGTPKNDVT 472
           S    +     D  L I D+++GK ++T   +S  +    + P++  I +  G+    V 
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS--GSFDESVR 154

Query: 473 VWTCPT----VSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
           +W   T     +   H   V  +  + D + + S++ DG   +W+
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 66/249 (26%), Positives = 105/249 (42%), Gaps = 20/249 (8%)

Query: 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--HFILSSGSR 333
           IS V+W  +   L   + +  +++WDV + K L+ + GH + V   ++N    ++ SGS 
Sbjct: 90  ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149

Query: 334 LGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQ 393
              V   DV+  +       H   V A+ ++ DG L+ S   DGL  IW      +A GQ
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD-----TASGQ 204

Query: 394 PLKVI--TQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPS--TNSQIC 449
            LK +    +  V  + + P    +LA      D  L + D + GK ++T +   N + C
Sbjct: 205 CLKTLIDDDNPPVSFVKFSPNGKYILA---ATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261

Query: 450 SLIWLPKTKEIATGQGTPKNDVTVWTCPT----VSRSGHRGRVLHLALSPDQTRVFSAAA 505
                  T       G+  N V +W   T        GH   V+  A  P +  + SAA 
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321

Query: 506 --DGTASVW 512
             D T  +W
Sbjct: 322 ENDKTIKLW 330



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 14/165 (8%)

Query: 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQ 413
           H +AV ++K+SP+G  L+S  +D L+ IW    G   +       T S     +    W 
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK-------TISGHKLGISDVAWS 96

Query: 414 SGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQ-ICSLIWLPKTKEIATGQGTPKNDVT 472
           S    +     D  L I D+++GK ++T   +S  +    + P++  I +  G+    V 
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS--GSFDESVR 154

Query: 473 VWTCPT----VSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
           +W   T     +   H   V  +  + D + + S++ DG   +W+
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 64/249 (25%), Positives = 105/249 (42%), Gaps = 20/249 (8%)

Query: 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--HFILSSGSR 333
           IS V+W  + + L   + +  ++LWDV + K L+ + GH + V   ++N    ++ SGS 
Sbjct: 86  ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSF 145

Query: 334 LGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQ 393
              V   +V+  +       H   V A+ ++  G L+ SG  DGL  IW      +A GQ
Sbjct: 146 DETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD-----AASGQ 200

Query: 394 PLKVIT--QSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPS--TNSQIC 449
            LK +    +  V  + + P    +L       D  L + D + G+ ++T +   N + C
Sbjct: 201 CLKTLVDDDNPPVSFVKFSPNGKYILT---ATLDNTLKLWDYSRGRCLKTYTGHKNEKYC 257

Query: 450 SLIWLPKTKEIATGQGTPKNDVTVWTCPT----VSRSGHRGRVLHLALSPDQTRVFSAAA 505
                  T       G+  N V +W   T        GH   V+  A  P +  + SAA 
Sbjct: 258 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAAL 317

Query: 506 --DGTASVW 512
             D T  +W
Sbjct: 318 ENDKTIKLW 326



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 53/224 (23%), Positives = 94/224 (41%), Gaps = 27/224 (12%)

Query: 265 ENIDLSLTCNYI------SSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVV 318
           EN + +L C  +      SSV +   G  LA  +++  + +W     K  + + GH   +
Sbjct: 27  ENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEI 86

Query: 319 GALSW----NHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGC 374
             ++W    +  + +S  +  +++  DVR  +       H   V    ++P   L+ SG 
Sbjct: 87  SDVAWSSDSSRLVSASDDKTLKLW--DVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGS 144

Query: 375 SDGLLTIWPHDPGASAQGQPLKVIT-QSTAVKAMDW-CPWQSGVLAIGGGMKDGRLHILD 432
            D  + IW         G+ LK ++  S  V A+ + C   SG L + G   DG   I D
Sbjct: 145 FDETVKIW-----EVKTGKCLKTLSAHSDPVSAVHFNC---SGSLIVSGSY-DGLCRIWD 195

Query: 433 INAGKSIQT--PSTNSQICSLIWLPKTKEIATGQGTPKNDVTVW 474
             +G+ ++T     N  +  + + P  K I T   T  N + +W
Sbjct: 196 AASGQCLKTLVDDDNPPVSFVKFSPNGKYILT--ATLDNTLKLW 237



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 39/169 (23%), Positives = 69/169 (40%), Gaps = 22/169 (13%)

Query: 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPG---ASAQGQPLKVITQSTAVKAMDWC 410
           H +AV ++K+SP+G  L+S  +D L+ IW    G    +  G  L++   +         
Sbjct: 40  HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVA--------- 90

Query: 411 PWQSGVLAIGGGMKDGRLHILDINAGKSIQT--PSTNSQICSLIWLPKTKEIATGQGTPK 468
            W S    +     D  L + D+ +GK ++T    +N   C     P    I+   G+  
Sbjct: 91  -WSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIIS---GSFD 146

Query: 469 NDVTVWTCPT----VSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
             V +W   T     + S H   V  +  +   + + S + DG   +W+
Sbjct: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 75/331 (22%), Positives = 134/331 (40%), Gaps = 50/331 (15%)

Query: 214 DSILQPEVKIHITGLRNDYYLNILDWSFQNLVAIALG-SAVYIWNGENHNGIENIDLS-- 270
           D I QP+    +  +      + L+   + ++++A   +  Y+ +G     +   DLS  
Sbjct: 89  DIIYQPQAIFRVRAVTR--CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTE 146

Query: 271 ---LTC----NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRL-RNMLGHLSVVGALS 322
               TC    +++ S+SW  +G  LA G   G++ LWD  T K++ R + GH   +  LS
Sbjct: 147 TPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLS 206

Query: 323 WNHF-------ILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCS 375
           W           ++S S+ G V   D    +       H Q+V  L+W  DG LL S   
Sbjct: 207 WEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQ 265

Query: 376 DGLLTIWPHDPGA-----SAQGQPLKVITQST--AVKAMDWCPWQSGV--LAIGGG---M 423
           D  + +W    G         G  +  +  ST  A++   + P ++ V    + G    +
Sbjct: 266 DRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQEL 325

Query: 424 KDGRLHILDINAGKSIQTPSTNSQICSL-IWLPKTKEIATGQGTPKNDVTVWTCPTVSRS 482
           K+  L   ++  G+  +   + S   +L +W P   +                 P    +
Sbjct: 326 KERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDK----------------KPLTRMT 369

Query: 483 GHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
           GH+  +  +  SPD   V SA+ D +  +W+
Sbjct: 370 GHQALINQVLFSPDSRIVASASFDKSIKLWD 400



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 33/109 (30%), Positives = 57/109 (52%), Gaps = 2/109 (1%)

Query: 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--HFILSSGSR 333
           I+ V +  +   +A  + +  ++LWD  T K L ++ GH++ V  ++W+    +L SGS 
Sbjct: 375 INQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSS 434

Query: 334 LGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
              +   DV+  +  +    H   V A+ WSPDG+ ++SG  D  L IW
Sbjct: 435 DSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483


>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
           [Homo sapiens]
          Length = 340

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 66/286 (23%), Positives = 112/286 (39%), Gaps = 31/286 (10%)

Query: 244 LVAIALGSAVYIWNGENHNGIENIDLS----LTCNYISSVSWIKEG------TCLAVGTS 293
           LV+ +    + IW+    N +  I L     +TC Y  S +++  G      +  ++ T 
Sbjct: 70  LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTR 129

Query: 294 EGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLR 353
           EG V++      + L    G+LS    L  N  I SSG     ++  D+   Q  VG   
Sbjct: 130 EGNVRV-----SRELPGHTGYLSCCRFLDDNQIITSSGDTTCALW--DIETGQQTVGFAG 182

Query: 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQ 413
           H   V +L  +PDGR   SG  D  + +W        Q      I   + + A+ + P  
Sbjct: 183 HSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQ----TFIGHESDINAVAFFP-- 236

Query: 414 SGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSL--IWLPKTKEIATGQGTPKNDV 471
               A   G  D    + D+ A + +   S ++ IC +  +   ++  +    G    + 
Sbjct: 237 -NGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLA-GYDDFNC 294

Query: 472 TVWTCPTVSR----SGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
            +W      R    +GH  RV  L ++ D   V + + D    +WN
Sbjct: 295 NIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 47/172 (27%), Positives = 68/172 (39%), Gaps = 18/172 (10%)

Query: 351 TLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDW 409
           TLR H   + A+ W  D RLL S   DG L IW           PL+    S+ V    +
Sbjct: 50  TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR----SSWVMTCAY 105

Query: 410 CPWQSGVLAIGGGMKD----GRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQG 465
            P  SG     GG+ +      L   + N   S + P     +    +L   + I +   
Sbjct: 106 AP--SGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGD 163

Query: 466 TPKNDVTVWTC----PTVSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
           T      +W       TV  +GH G V+ L+L+PD     S A D +  +W+
Sbjct: 164 T---TCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWD 212


>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
           [Homo sapiens]
          Length = 340

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 67/286 (23%), Positives = 111/286 (38%), Gaps = 31/286 (10%)

Query: 244 LVAIALGSAVYIWNGENHNGIENIDLS----LTCNYISSVSWIKEG------TCLAVGTS 293
           LV+ +    + IW+    N +  I L     +TC Y  S +++  G      +   + T 
Sbjct: 70  LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129

Query: 294 EGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLR 353
           EG V++      + L    G+LS    L  N  + SSG     ++  D+   Q       
Sbjct: 130 EGNVRV-----SRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW--DIETGQQTTTFTG 182

Query: 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQ 413
           H   V +L  +PD RL  SG  D    +W    G   Q          + + A+  C + 
Sbjct: 183 HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ----TFTGHESDINAI--CFFP 236

Query: 414 SGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSL--IWLPKTKEIATGQGTPKNDV 471
           +G  A   G  D    + D+ A + + T S ++ IC +  +   K+  +    G    + 
Sbjct: 237 NG-NAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA-GYDDFNC 294

Query: 472 TVWTCPTVSR----SGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
            VW      R    +GH  RV  L ++ D   V + + D    +WN
Sbjct: 295 NVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 48/186 (25%), Positives = 72/186 (38%), Gaps = 46/186 (24%)

Query: 351 TLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDW 409
           TLR H   + A+ W  D RLL S   DG L IW           PL+    S+ V    +
Sbjct: 50  TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR----SSWVMTCAY 105

Query: 410 CPWQSGVLAIGGGM-----------KDGRLHILDINAGKS-----------IQTPSTNSQ 447
            P  SG     GG+           ++G + +    AG +            Q  +++  
Sbjct: 106 AP--SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD 163

Query: 448 ICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVSRSGHRGRVLHLALSPDQTRVFSAAADG 507
               +W     +I TGQ             T + +GH G V+ L+L+PD     S A D 
Sbjct: 164 TTCALW-----DIETGQ------------QTTTFTGHTGDVMSLSLAPDTRLFVSGACDA 206

Query: 508 TASVWN 513
           +A +W+
Sbjct: 207 SAKLWD 212


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 45/165 (27%), Positives = 76/165 (46%), Gaps = 14/165 (8%)

Query: 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWC-PW 412
           H  AV  L ++ DG +L S  +D  + +W      S  G+ +K +   T+   ++ C P 
Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWD-----SETGERVKRLKGHTSF--VNSCYPA 160

Query: 413 QSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVT 472
           + G   +  G  DG + + DI    +IQT     Q+ ++ +   + +I +  G   ND+ 
Sbjct: 161 RRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIIS--GGIDNDIK 218

Query: 473 VWTCP----TVSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
           VW       T +  GH   V  L+LS + + + S A D T  VW+
Sbjct: 219 VWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 263



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 55/249 (22%), Positives = 97/249 (38%), Gaps = 46/249 (18%)

Query: 284 EGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGA---LSWNHFILSSGSRLGRVYHH 340
           +G+ L   +++  V +WD  T +R++ + GH S V +         ++ +GS  G V   
Sbjct: 120 DGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLW 179

Query: 341 DVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWP------------HDPGA 388
           D+R  +  + T ++   V A+ ++     + SG  D  + +W             H    
Sbjct: 180 DIR-KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSV 238

Query: 389 -----SAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPS 443
                S++G  L        V+  D  P+      +   +  G +H  + N  +      
Sbjct: 239 TGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCV--KIFQGNVHNFEKNLLR------ 290

Query: 444 TNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVSR------SGHRGRVLHLALSPDQ 497
                CS  W P   +IA G      D  V+   T SR       GH G +  +A  PD+
Sbjct: 291 -----CS--WSPDGSKIAAGSA----DRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE 339

Query: 498 TRVFSAAAD 506
             + SA++D
Sbjct: 340 PIIISASSD 348



 Score = 35.8 bits (81), Expect = 0.096
 Identities = 24/93 (25%), Positives = 48/93 (51%), Gaps = 11/93 (11%)

Query: 253 VYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNML 312
           V I+ G  HN  +N+   L C      SW  +G+ +A G+++  V +WD  +++ L  + 
Sbjct: 274 VKIFQGNVHNFEKNL---LRC------SWSPDGSKIAAGSADRFVYVWDTTSRRILYKLP 324

Query: 313 GHLSVVGALSW--NHFILSSGSRLGRVYHHDVR 343
           GH   +  +++  +  I+ S S   R+Y  +++
Sbjct: 325 GHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 13/31 (41%), Positives = 20/31 (64%)

Query: 483 GHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
           GH G V+ L  + D + +FSA+ D T +VW+
Sbjct: 107 GHSGAVMELHYNTDGSMLFSASTDKTVAVWD 137


>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
          Length = 193

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 33/109 (30%), Positives = 57/109 (52%), Gaps = 2/109 (1%)

Query: 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--HFILSSGSR 333
           I+ V +  +   +A  + +  ++LWD  T K L ++ GH++ V  ++W+    +L SGS 
Sbjct: 83  INQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSS 142

Query: 334 LGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
              +   DV+  +  +    H   V A+ WSPDG+ ++SG  D  L IW
Sbjct: 143 DSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 191



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 26/114 (22%), Positives = 50/114 (43%), Gaps = 14/114 (12%)

Query: 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPG---ASAQGQPLKVITQSTAVKAMDWC 410
           H+  +  + +SPD R+++S   D  + +W    G   AS +G           V A+   
Sbjct: 79  HQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGH----------VAAVYQI 128

Query: 411 PWQSGVLAIGGGMKDGRLHILDINAGK-SIQTPSTNSQICSLIWLPKTKEIATG 463
            W +    +  G  D  L + D+ A K ++  P    ++ ++ W P  + +A+G
Sbjct: 129 AWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASG 182


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 33/98 (33%), Positives = 56/98 (57%), Gaps = 4/98 (4%)

Query: 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW--NHFILSSGSRLGRVYHHDVRVA 345
           +A G+++  V+LWDV+    +R   GH   + +L++  N   L++G+  GRV   D+   
Sbjct: 642 VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701

Query: 346 QHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
              VG L+ H   VC+L++S DG +L+SG  D  + +W
Sbjct: 702 LM-VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 56/225 (24%), Positives = 89/225 (39%), Gaps = 20/225 (8%)

Query: 298 QLWDVVTKKRLRNMLGHLSVVGALSWN---HFILSSGSRLGRVYHHDVRVAQHHVGTLRH 354
           ++ D  T   L+ + GH   V   S++   +++LSS S  G V    ++     VG   H
Sbjct: 526 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSS-SEDGTVRLWSLQTFTCLVGYKGH 584

Query: 355 KQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTA-VKAMDWCPWQ 413
              V   ++SP G    SG  D +  +W  D       QPL++     A V    + P  
Sbjct: 585 NYPVWDTQFSPYGYYFVSGGHDRVARLWATD-----HYQPLRIFAGHLADVNCTRFHP-N 638

Query: 414 SGVLAIGGGMKDGRLHILDINAGKSIQT-PSTNSQICSLIWLPKTKEIATGQGTPKNDVT 472
           S  +A G    D  + + D+  G  ++        I SL + P  + +ATG    +  V 
Sbjct: 639 SNYVATGSA--DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGR--VL 694

Query: 473 VWTCP----TVSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
           +W            GH   V  L  S D   + S + D T  +W+
Sbjct: 695 LWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 57/249 (22%), Positives = 93/249 (37%), Gaps = 35/249 (14%)

Query: 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLG 335
           +++V    + + +A G ++  V++W V T K+LR      SV  A   +     S   L 
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSV-TPKKLR------SVKQASDLSLIDKESDDVLE 525

Query: 336 RVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPL 395
           R+   D + A        H   V    +SPD   L S   DG + +W            L
Sbjct: 526 RIM--DEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWS-----------L 572

Query: 396 KVITQSTAVKAMDWCPWQS-----GVLAIGGGM-KDGRLHILDINAGKSIQTPSTNSQIC 449
           +  T     K  ++  W +     G   + GG  +  RL   D      I         C
Sbjct: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 632

Query: 450 SLIWLPKTKEIATGQGTPKNDVTVW-----TCPTVSRSGHRGRVLHLALSPDQTRVFSAA 504
           +    P +  +ATG       V +W      C  +  +GH+G +  L  SP+   + + A
Sbjct: 633 TRFH-PNSNYVATGSAD--RTVRLWDVLNGNCVRIF-TGHKGPIHSLTFSPNGRFLATGA 688

Query: 505 ADGTASVWN 513
            DG   +W+
Sbjct: 689 TDGRVLLWD 697


>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
           [Homo sapiens]
          Length = 340

 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 67/295 (22%), Positives = 113/295 (38%), Gaps = 33/295 (11%)

Query: 237 LDWSFQN--LVAIALGSAVYIWNGENHNGIENIDLS----LTCNYISSVSWIKEG----- 285
           + W + +  LV+ +    + IW+    N +  I L     +TC Y  S +++  G     
Sbjct: 61  MHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120

Query: 286 -TCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRV 344
            +   + T EG V++      + L    G+LS    L  +  + SSG     ++  D+  
Sbjct: 121 CSIYNLKTREGNVRV-----SRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALW--DIET 173

Query: 345 AQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAV 404
           AQ       H   V +L  SPD R   SG  D    +W    G   Q     V    + +
Sbjct: 174 AQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHV----SDI 229

Query: 405 KAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSL--IWLPKTKEIAT 462
            A+ + P      A   G  D    + D+ A + +   S ++ IC +  +   K+  +  
Sbjct: 230 NAVSFFP---NGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLL 286

Query: 463 GQGTPKNDVTVWTCPTVSR----SGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
             G    +  VW      R    +GH  RV  L ++ D   V + + D    +WN
Sbjct: 287 A-GYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 48/172 (27%), Positives = 70/172 (40%), Gaps = 18/172 (10%)

Query: 351 TLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDW 409
           TLR H   + A+ W  D RLL S   DG L IW           PL+    S+ V    +
Sbjct: 50  TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLR----SSWVMTCAY 105

Query: 410 CPWQSGVLAIGGGMKD----GRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQG 465
            P  SG     GG+ +      L   + N   S + P     +    +L  + +I T  G
Sbjct: 106 AP--SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDS-QIVTSSG 162

Query: 466 TPKNDVTVWTCPTVSRS----GHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
                  +W   T  ++    GH G V+ L+LSPD     S A D ++ +W+
Sbjct: 163 D--TTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWD 212


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 53/243 (21%), Positives = 95/243 (39%), Gaps = 22/243 (9%)

Query: 274 NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--HFILSSG 331
           N  S V     G  LA G  +  V LW +     + ++ GH S V ++  N    ++ +G
Sbjct: 22  NVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAG 81

Query: 332 SRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQ 391
           S+ G +   D+  A+     + HK  +C+L + P G  ++SG  D  + +W        +
Sbjct: 82  SQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW----DIRRK 137

Query: 392 GQPLKVITQSTAVKAMDWCP---WQSGVLAIGGGMKDGRLHILDINAGKSI-QTPSTNSQ 447
           G   +    S AV+ + + P   W      +     D  + + D+ AGK + + P     
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKW------LASAADDHTVKLWDLTAGKMMSEFPGHTGP 191

Query: 448 ICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS----RSGHRGRVLHLALSPDQTRVFSA 503
           +  + + P   E     G+    +  W            G  G V  +  +PD   ++S 
Sbjct: 192 VNVVEFHP--NEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249

Query: 504 AAD 506
             D
Sbjct: 250 CQD 252



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 28/97 (28%), Positives = 44/97 (45%), Gaps = 2/97 (2%)

Query: 284 EGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW--NHFILSSGSRLGRVYHHD 341
           +G  LA    +  V+LWD+   K +    GH   V  + +  N ++L+SGS    +   D
Sbjct: 158 DGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217

Query: 342 VRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGL 378
           +   Q           V ++ ++PDG  L SGC D L
Sbjct: 218 LEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSL 254



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 36/152 (23%), Positives = 67/152 (44%), Gaps = 14/152 (9%)

Query: 367 GRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDG 426
           GRLL++G  D  + +W       +  +P  +++ +     ++     +    I  G + G
Sbjct: 33  GRLLATGGDDCRVNLW-------SINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSG 85

Query: 427 RLHILDINAGKSIQT-PSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCP----TVSR 481
            + + D+ A K ++T     + ICSL + P  + +A+G  +   ++ +W           
Sbjct: 86  SIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASG--SQDTNIKLWDIRRKGCVFRY 143

Query: 482 SGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
            GH   V  L  SPD   + SAA D T  +W+
Sbjct: 144 RGHSQAVRCLRFSPDGKWLASAADDHTVKLWD 175


>gi|157739942 gemin 5 [Homo sapiens]
          Length = 1508

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 30/129 (23%), Positives = 61/129 (47%), Gaps = 24/129 (18%)

Query: 277 SSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNH---------FI 327
           + +SW  +G  +A+G  +G ++++ +   K +  +  H  +V  +SW+H         ++
Sbjct: 540 TEISWKADGKIMALGNEDGSIEIFQIPNLKLICTIQQHHKLVNTISWHHEHGSQPELSYL 599

Query: 328 LSSGSRLGRVYHHD------------VRVAQHHVGTLRHKQAVCALKWSP--DGRLLSSG 373
           ++SGS    +Y H+            V + + +     H   + ++ WSP  DGRL+S+ 
Sbjct: 600 MASGSNNAVIYVHNLKTVIESSPESPVTITEPYRTLSGHTAKITSVAWSPHHDGRLVSAS 659

Query: 374 CSDGLLTIW 382
             DG   +W
Sbjct: 660 -YDGTAQVW 667



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 72/304 (23%), Positives = 126/304 (41%), Gaps = 65/304 (21%)

Query: 245 VAIALGSA-VYIWNG---ENHNGIENIDLSLTCNYISSVSW--IKEGTCLAVGTSEGEVQ 298
           +AI +G   + +WN    +N+  ++N    +    ++++ W   KEG CLA GT +G+V 
Sbjct: 395 LAIGVGDGMIRVWNTLSIKNNYDVKNFWQGVKSK-VTALCWHPTKEG-CLAFGTDDGKVG 452

Query: 299 LWDVVTKKRLR-NMLGHLSVVGALSWN---------------HFILSSGSRLGRVYHH-- 340
           L+D  + K  + +   H   V  L+W                   L S    G V  H  
Sbjct: 453 LYDTYSNKPPQISSTYHKKTVYTLAWGPPVPPMSLGGEGDRPSLALYSCGGEGIVLQHNP 512

Query: 341 --------DVRVAQHHVGTLRHKQAV-CALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQ 391
                   D+        ++++K  V   + W  DG++++ G  DG + I+        Q
Sbjct: 513 WKLSGEAFDINKLIRDTNSIKYKLPVHTEISWKADGKIMALGNEDGSIEIF--------Q 564

Query: 392 GQPLKVI-TQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICS 450
              LK+I T     K ++   W                H         + + S N    +
Sbjct: 565 IPNLKLICTIQQHHKLVNTISWH-------------HEHGSQPELSYLMASGSNN----A 607

Query: 451 LIWLPKTKEIATGQGTPKNDVTVWTCPTVSRSGHRGRVLHLALSPDQT-RVFSAAADGTA 509
           +I++   K +   + +P++ VT+ T P  + SGH  ++  +A SP    R+ SA+ DGTA
Sbjct: 608 VIYVHNLKTVI--ESSPESPVTI-TEPYRTLSGHTAKITSVAWSPHHDGRLVSASYDGTA 664

Query: 510 SVWN 513
            VW+
Sbjct: 665 QVWD 668



 Score = 33.1 bits (74), Expect = 0.62
 Identities = 43/196 (21%), Positives = 76/196 (38%), Gaps = 30/196 (15%)

Query: 289 AVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN---HFILSSGSRLGRV--YHHDVR 343
           A  + +G V++WDV TK  +     H   +  L W+     ++ SG   G V  Y  +  
Sbjct: 83  ATSSDDGTVKIWDVETKTVVTEHALHQHTISTLHWSPRVKDLIVSGDEKGVVFCYWFNRN 142

Query: 344 VAQHHVGTLRHKQAVCALKWSPDGR-LLSSGCSDGLLTIWPHDPGASAQGQPL-KVITQS 401
            +QH        + +  L  SP    L++ G  DG++ I       S +G+ + ++    
Sbjct: 143 DSQH---LFIEPRTIFCLTCSPHHEDLVAIGYKDGIVVI----IDISKKGEVIHRLRGHD 195

Query: 402 TAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGK-SIQTPSTNSQICSLIWLPKTKEI 460
             + ++ WCP                   L IN  + S +   TN    ++   P TK  
Sbjct: 196 DEIHSIAWCPLPGE-------------DCLSINQEETSEEAEITNGN--AVAQAPVTKGC 240

Query: 461 ATGQGTPKNDVTVWTC 476
               G+    + +W+C
Sbjct: 241 YLATGSKDQTIRIWSC 256



 Score = 29.3 bits (64), Expect = 9.0
 Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 1/50 (2%)

Query: 276 ISSVSWIKEGTCLAVGTS-EGEVQLWDVVTKKRLRNMLGHLSVVGALSWN 324
           I+SV+W        V  S +G  Q+WD + ++ L N  GH   +  ++W+
Sbjct: 642 ITSVAWSPHHDGRLVSASYDGTAQVWDALREEPLCNFRGHRGRLLCVAWS 691


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 71/326 (21%), Positives = 119/326 (36%), Gaps = 84/326 (25%)

Query: 199 VRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWSFQNLVAIALGSAVYIWNG 258
           VR   F  +  G++N S   P+ ++ +TG  +     +  W  +        S   +W  
Sbjct: 11  VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGC---VYGWETR--------SGQLLWRL 59

Query: 259 ENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVV 318
             H G            +    +  +G   A  + +  V+LWDV   K LR + GH   V
Sbjct: 60  GGHTGP-----------VKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSV 108

Query: 319 GALSW--NHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSD 376
             +S+  +   L+SG    RV   DV+  Q     + H+ ++ +  +SP    L++G  D
Sbjct: 109 ETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWD 168

Query: 377 GLLTIWPHDPGASAQGQPLKVITQSTAVKAMD--------WCPWQSGVLAIGGGMKDGRL 428
             + IW            L+++T + + +A++         C   SG+LA   G  D  +
Sbjct: 169 STVHIW-----------DLRMVTPAVSHQALEGHSANISCLCYSASGLLA--SGSWDKTI 215

Query: 429 HILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVSRSGHRGRV 488
           H                      IW P T  +                  +   GH   V
Sbjct: 216 H----------------------IWKPTTSSL-----------------LIQLKGHVTWV 236

Query: 489 LHLALSPDQTRVFSAAADGTASVWNC 514
             +A SPD+  + SA       VW+C
Sbjct: 237 KSIAFSPDELWLASAGYSRMVKVWDC 262



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 47/171 (27%), Positives = 81/171 (47%), Gaps = 13/171 (7%)

Query: 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFI--LSSGSR 333
           + +VS+  +   LA G  +  V LWDV + + LR ++GH   + +  ++  +  L++GS 
Sbjct: 108 VETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW 167

Query: 334 LGRVYHHDVRV---AQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASA 390
              V+  D+R+   A  H     H   +  L +S  G LL+SG  D  + IW   P  S+
Sbjct: 168 DSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIW--KPTTSS 224

Query: 391 QGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQT 441
               LK     T VK++ + P +  + + G       + + D N GK ++T
Sbjct: 225 LLIQLK--GHVTWVKSIAFSPDELWLASAG---YSRMVKVWDCNTGKCLET 270


>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
          Length = 1298

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 61/253 (24%), Positives = 106/253 (41%), Gaps = 25/253 (9%)

Query: 276 ISSVSWIKEG-TCLAVGTSEGEVQLWDVVTKKRLRNMLGH-LSVVGALSWNHFILSSGSR 333
           I S+SW   G  C+A GTS     +W+V   K ++    H  + +  ++W+H       R
Sbjct: 415 IYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSH---KDSKR 471

Query: 334 LGRVYHHDVRVAQHHVGTLRHK----QAVCALKWSPDGR-LLSSGCSDGLLTIWPHDPGA 388
           +         + +   G + HK     AV    WS + + ++++GC D  + ++     A
Sbjct: 472 IATCSSDGFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVY---YVA 528

Query: 389 SAQGQPLKVITQSTA-VKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTN-S 446
           ++  QPLKV +  TA V  + W P + G+L    G  DG + I D      I   + + +
Sbjct: 529 TSSDQPLKVFSGHTAKVFHVKWSPLREGILC--SGSDDGTVRIWDYTQDACINILNGHTA 586

Query: 447 QICSLIWLPKTKEIATGQGTPKNDVTVW-----TCPTVSRSGHRGRVLHLALSPDQT-RV 500
            +  L+W  +   +    G+    + VW     TC       H   V  L   P +   +
Sbjct: 587 PVRGLMWNTEIPYLLI-SGSWDYTIKVWDTREGTCVDTVYD-HGADVYGLTCHPSRPFTM 644

Query: 501 FSAAADGTASVWN 513
            S + D T  +W+
Sbjct: 645 ASCSRDSTVRLWS 657



 Score = 33.1 bits (74), Expect = 0.62
 Identities = 44/199 (22%), Positives = 86/199 (43%), Gaps = 25/199 (12%)

Query: 276 ISSVSWIKEGTCL-AVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW---NHFILSSG 331
           I+++SW      L A G+++  V +W+V  +K +  +     +  +LSW      +++  
Sbjct: 62  ITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVAFV 121

Query: 332 SRLGRVYHHDVRVAQHHVGTLRHKQA------VCALKWSPDGR-LLSSGCSDGLLTIWPH 384
           S  G ++     ++    G + HK A      +C  +W    +  +  G  DG L+I+  
Sbjct: 122 SHRGPLFIW--TISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSIF-- 177

Query: 385 DPGASAQ-----GQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSI 439
            PG   Q      + L+   +   V A++W P  +  L +   +  G + ++D  +   I
Sbjct: 178 HPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLV-VNLHYG-IRLVDSESLSCI 235

Query: 440 QT---PSTNSQICSLIWLP 455
            T   PS  + +  L W+P
Sbjct: 236 TTFNLPSAAASVQCLAWVP 254


>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
          Length = 1322

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 61/253 (24%), Positives = 106/253 (41%), Gaps = 25/253 (9%)

Query: 276 ISSVSWIKEG-TCLAVGTSEGEVQLWDVVTKKRLRNMLGH-LSVVGALSWNHFILSSGSR 333
           I S+SW   G  C+A GTS     +W+V   K ++    H  + +  ++W+H       R
Sbjct: 439 IYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSH---KDSKR 495

Query: 334 LGRVYHHDVRVAQHHVGTLRHK----QAVCALKWSPDGR-LLSSGCSDGLLTIWPHDPGA 388
           +         + +   G + HK     AV    WS + + ++++GC D  + ++     A
Sbjct: 496 IATCSSDGFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVY---YVA 552

Query: 389 SAQGQPLKVITQSTA-VKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTN-S 446
           ++  QPLKV +  TA V  + W P + G+L    G  DG + I D      I   + + +
Sbjct: 553 TSSDQPLKVFSGHTAKVFHVKWSPLREGILC--SGSDDGTVRIWDYTQDACINILNGHTA 610

Query: 447 QICSLIWLPKTKEIATGQGTPKNDVTVW-----TCPTVSRSGHRGRVLHLALSPDQT-RV 500
            +  L+W  +   +    G+    + VW     TC       H   V  L   P +   +
Sbjct: 611 PVRGLMWNTEIPYLLI-SGSWDYTIKVWDTREGTCVDTVYD-HGADVYGLTCHPSRPFTM 668

Query: 501 FSAAADGTASVWN 513
            S + D T  +W+
Sbjct: 669 ASCSRDSTVRLWS 681



 Score = 33.1 bits (74), Expect = 0.62
 Identities = 44/199 (22%), Positives = 86/199 (43%), Gaps = 25/199 (12%)

Query: 276 ISSVSWIKEGTCL-AVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW---NHFILSSG 331
           I+++SW      L A G+++  V +W+V  +K +  +     +  +LSW      +++  
Sbjct: 86  ITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVAFV 145

Query: 332 SRLGRVYHHDVRVAQHHVGTLRHKQA------VCALKWSPDGR-LLSSGCSDGLLTIWPH 384
           S  G ++     ++    G + HK A      +C  +W    +  +  G  DG L+I+  
Sbjct: 146 SHRGPLFIW--TISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSIF-- 201

Query: 385 DPGASAQ-----GQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSI 439
            PG   Q      + L+   +   V A++W P  +  L +   +  G + ++D  +   I
Sbjct: 202 HPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLV-VNLHYG-IRLVDSESLSCI 259

Query: 440 QT---PSTNSQICSLIWLP 455
            T   PS  + +  L W+P
Sbjct: 260 TTFNLPSAAASVQCLAWVP 278


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 90/424 (21%), Positives = 157/424 (37%), Gaps = 82/424 (19%)

Query: 156 SVASKGQKCLKQLFVTQNVVQQANGKMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDS 215
           + A++     K   +T   + Q N      +  E    G ++G  + + H K      D 
Sbjct: 110 AAATEASAMAKAATMTPAAISQQNPP----KNREATVNGEENGAHEINNHSKPMEIDGDV 165

Query: 216 ILQPEVKIHITGLRNDYYLNILDWS-FQNLVAIALG-SAVYIWN-GENHNGIENIDLSLT 272
            + P     + G  ++ +  I  W+   +L+A   G S   IWN  EN NG     +   
Sbjct: 166 EIPPNKATVLRGHESEVF--ICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 223

Query: 273 C-----------NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLG-HLSVVGA 320
           C             ++S+ W  +GT LA+G+ +G  ++W       L + LG H   + A
Sbjct: 224 CIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFA 281

Query: 321 LSWN---HFILSSG---------SRLGRV-----YH------------------------ 339
           L WN   +++LS+G         +  G       +H                        
Sbjct: 282 LKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCI 341

Query: 340 HDVRVA-QHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKV 397
           H  R+   H V T + H   V A+KW P G LL+S   D  L IW     A        +
Sbjct: 342 HVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVH----DL 397

Query: 398 ITQSTAVKAMDWCPW------QSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQ-ICS 450
              S  +  + W P        +  + +     D  + + D+  G    T   + + + S
Sbjct: 398 QAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYS 457

Query: 451 LIWLPKTKEIATGQGTPKNDVTVWTCPT---VSRSGHRGRVLHLALSPDQTRVFSAAADG 507
           + + P  K +A+  G+    V +W   +   V      G +  +  +    +V ++A+DG
Sbjct: 458 VAFSPDGKYLAS--GSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDG 515

Query: 508 TASV 511
           +  V
Sbjct: 516 SVCV 519



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 36/171 (21%), Positives = 71/171 (41%), Gaps = 19/171 (11%)

Query: 274 NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--------- 324
           N ++++ W   G  LA  + +  +++W +     + ++  H   +  + W+         
Sbjct: 360 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNP 419

Query: 325 --HFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
               +L+S S    V   DV         ++H++ V ++ +SPDG+ L+SG  D  + IW
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479

Query: 383 PHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDI 433
               G+           Q T     + C W +    +G    DG + +LD+
Sbjct: 480 NTQSGSLVHSY------QGTG-GIFEVC-WNARGDKVGASASDGSVCVLDL 522



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 48/199 (24%), Positives = 75/199 (37%), Gaps = 25/199 (12%)

Query: 323 WNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
           WN    S+G     V  H +R   H V +    + V +L W+ DG LL+ G  DG   IW
Sbjct: 206 WNLNENSNGGSTQLVLRHCIREGGHDVPS---NKDVTSLDWNSDGTLLAMGSYDGFARIW 262

Query: 383 PHDPG-ASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQT 441
             +   AS  GQ          + A+ W    + VL+ G    D    I D + G++ Q 
Sbjct: 263 TENGNLASTLGQ------HKGPIFALKWNKKGNYVLSAG---VDKTTIIWDAHTGEAKQQ 313

Query: 442 -PSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTC------PTVSRSGHRGRVLHLALS 494
            P  ++    + W       +        D+ +  C      P  +  GH   V  +   
Sbjct: 314 FPFHSAPALDVDWQNNMTFASC-----STDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWD 368

Query: 495 PDQTRVFSAAADGTASVWN 513
           P    + S + D T  +W+
Sbjct: 369 PSGMLLASCSDDMTLKIWS 387


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 90/424 (21%), Positives = 157/424 (37%), Gaps = 82/424 (19%)

Query: 156 SVASKGQKCLKQLFVTQNVVQQANGKMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDS 215
           + A++     K   +T   + Q N      +  E    G ++G  + + H K      D 
Sbjct: 110 AAATEASAMAKAATMTPAAISQQNPP----KNREATVNGEENGAHEINNHSKPMEIDGDV 165

Query: 216 ILQPEVKIHITGLRNDYYLNILDWS-FQNLVAIALG-SAVYIWN-GENHNGIENIDLSLT 272
            + P     + G  ++ +  I  W+   +L+A   G S   IWN  EN NG     +   
Sbjct: 166 EIPPNKATVLRGHESEVF--ICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 223

Query: 273 C-----------NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLG-HLSVVGA 320
           C             ++S+ W  +GT LA+G+ +G  ++W       L + LG H   + A
Sbjct: 224 CIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFA 281

Query: 321 LSWN---HFILSSG---------SRLGRV-----YH------------------------ 339
           L WN   +++LS+G         +  G       +H                        
Sbjct: 282 LKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCI 341

Query: 340 HDVRVA-QHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKV 397
           H  R+   H V T + H   V A+KW P G LL+S   D  L IW     A        +
Sbjct: 342 HVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVH----DL 397

Query: 398 ITQSTAVKAMDWCPW------QSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQ-ICS 450
              S  +  + W P        +  + +     D  + + D+  G    T   + + + S
Sbjct: 398 QAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYS 457

Query: 451 LIWLPKTKEIATGQGTPKNDVTVWTCPT---VSRSGHRGRVLHLALSPDQTRVFSAAADG 507
           + + P  K +A+  G+    V +W   +   V      G +  +  +    +V ++A+DG
Sbjct: 458 VAFSPDGKYLAS--GSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDG 515

Query: 508 TASV 511
           +  V
Sbjct: 516 SVCV 519



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 36/171 (21%), Positives = 71/171 (41%), Gaps = 19/171 (11%)

Query: 274 NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--------- 324
           N ++++ W   G  LA  + +  +++W +     + ++  H   +  + W+         
Sbjct: 360 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNP 419

Query: 325 --HFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
               +L+S S    V   DV         ++H++ V ++ +SPDG+ L+SG  D  + IW
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479

Query: 383 PHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDI 433
               G+           Q T     + C W +    +G    DG + +LD+
Sbjct: 480 NTQSGSLVHSY------QGTG-GIFEVC-WNARGDKVGASASDGSVCVLDL 522



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 48/199 (24%), Positives = 75/199 (37%), Gaps = 25/199 (12%)

Query: 323 WNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
           WN    S+G     V  H +R   H V +    + V +L W+ DG LL+ G  DG   IW
Sbjct: 206 WNLNENSNGGSTQLVLRHCIREGGHDVPS---NKDVTSLDWNSDGTLLAMGSYDGFARIW 262

Query: 383 PHDPG-ASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQT 441
             +   AS  GQ          + A+ W    + VL+ G    D    I D + G++ Q 
Sbjct: 263 TENGNLASTLGQ------HKGPIFALKWNKKGNYVLSAG---VDKTTIIWDAHTGEAKQQ 313

Query: 442 -PSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTC------PTVSRSGHRGRVLHLALS 494
            P  ++    + W       +        D+ +  C      P  +  GH   V  +   
Sbjct: 314 FPFHSAPALDVDWQNNMTFASC-----STDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWD 368

Query: 495 PDQTRVFSAAADGTASVWN 513
           P    + S + D T  +W+
Sbjct: 369 PSGMLLASCSDDMTLKIWS 387


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 90/424 (21%), Positives = 157/424 (37%), Gaps = 82/424 (19%)

Query: 156 SVASKGQKCLKQLFVTQNVVQQANGKMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDS 215
           + A++     K   +T   + Q N      +  E    G ++G  + + H K      D 
Sbjct: 110 AAATEASAMAKAATMTPAAISQQNPP----KNREATVNGEENGAHEINNHSKPMEIDGDV 165

Query: 216 ILQPEVKIHITGLRNDYYLNILDWS-FQNLVAIALG-SAVYIWN-GENHNGIENIDLSLT 272
            + P     + G  ++ +  I  W+   +L+A   G S   IWN  EN NG     +   
Sbjct: 166 EIPPNKATVLRGHESEVF--ICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 223

Query: 273 C-----------NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLG-HLSVVGA 320
           C             ++S+ W  +GT LA+G+ +G  ++W       L + LG H   + A
Sbjct: 224 CIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFA 281

Query: 321 LSWN---HFILSSG---------SRLGRV-----YH------------------------ 339
           L WN   +++LS+G         +  G       +H                        
Sbjct: 282 LKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCI 341

Query: 340 HDVRVA-QHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKV 397
           H  R+   H V T + H   V A+KW P G LL+S   D  L IW     A        +
Sbjct: 342 HVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVH----DL 397

Query: 398 ITQSTAVKAMDWCPW------QSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQ-ICS 450
              S  +  + W P        +  + +     D  + + D+  G    T   + + + S
Sbjct: 398 QAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYS 457

Query: 451 LIWLPKTKEIATGQGTPKNDVTVWTCPT---VSRSGHRGRVLHLALSPDQTRVFSAAADG 507
           + + P  K +A+  G+    V +W   +   V      G +  +  +    +V ++A+DG
Sbjct: 458 VAFSPDGKYLAS--GSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDG 515

Query: 508 TASV 511
           +  V
Sbjct: 516 SVCV 519



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 36/171 (21%), Positives = 71/171 (41%), Gaps = 19/171 (11%)

Query: 274 NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--------- 324
           N ++++ W   G  LA  + +  +++W +     + ++  H   +  + W+         
Sbjct: 360 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNP 419

Query: 325 --HFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
               +L+S S    V   DV         ++H++ V ++ +SPDG+ L+SG  D  + IW
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479

Query: 383 PHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDI 433
               G+           Q T     + C W +    +G    DG + +LD+
Sbjct: 480 NTQSGSLVHSY------QGTG-GIFEVC-WNARGDKVGASASDGSVCVLDL 522



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 48/199 (24%), Positives = 75/199 (37%), Gaps = 25/199 (12%)

Query: 323 WNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
           WN    S+G     V  H +R   H V +    + V +L W+ DG LL+ G  DG   IW
Sbjct: 206 WNLNENSNGGSTQLVLRHCIREGGHDVPS---NKDVTSLDWNSDGTLLAMGSYDGFARIW 262

Query: 383 PHDPG-ASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQT 441
             +   AS  GQ          + A+ W    + VL+ G    D    I D + G++ Q 
Sbjct: 263 TENGNLASTLGQ------HKGPIFALKWNKKGNYVLSAG---VDKTTIIWDAHTGEAKQQ 313

Query: 442 -PSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTC------PTVSRSGHRGRVLHLALS 494
            P  ++    + W       +        D+ +  C      P  +  GH   V  +   
Sbjct: 314 FPFHSAPALDVDWQNNMTFASC-----STDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWD 368

Query: 495 PDQTRVFSAAADGTASVWN 513
           P    + S + D T  +W+
Sbjct: 369 PSGMLLASCSDDMTLKIWS 387


>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
          Length = 670

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 67/251 (26%), Positives = 103/251 (41%), Gaps = 51/251 (20%)

Query: 285 GTCLAVGTSEGEVQLWDVVTKKRLRNML-GHLSVVGALSWNHFILSSGSRLGRVYHHDVR 343
           G  L  G+S+  +++WD  T  + +  L GH  +V AL      L SGS    +   D++
Sbjct: 408 GDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQ 467

Query: 344 VAQHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQST 402
             Q  V T+R H   VC L  S +  +L SG S   + +W         G  LK+  + T
Sbjct: 468 NLQK-VNTIRAHDNPVCTLVSSHN--VLFSG-SLKAIKVW------DIVGTELKLKKELT 517

Query: 403 AVKAMDWCPWQSGVLAIGGGMKDGR--------------LHILDINAGKSIQTPSTNSQI 448
            +       W   ++A    +  G               +H+L  + G       TN  I
Sbjct: 518 GLNH-----WVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHI 572

Query: 449 CSLIWLPKTKEIATGQGTPKNDVTVWTCPTVSR----SGHRGRVLHLAL--SPDQTRVFS 502
                           GT +N + VW   +  +    +GH G V  LA+  +PDQT+VFS
Sbjct: 573 VC--------------GTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFS 618

Query: 503 AAADGTASVWN 513
           A+ D +  VW+
Sbjct: 619 ASYDRSLRVWS 629



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 31/101 (30%), Positives = 50/101 (49%), Gaps = 10/101 (9%)

Query: 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALS------WNHFILSSGSRLGRVYHHD 341
           +  GT E  + +WD+ +K+++R + GH+  V AL+            +S  R  RV+  D
Sbjct: 572 IVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMD 631

Query: 342 VRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
             +    +  LRH+ +V AL  S  GRL  SG  D  + +W
Sbjct: 632 NMICTQTL--LRHQGSVTALAVS-RGRLF-SGAVDSTVKVW 668


>gi|41281447 intraflagellar transport 140 [Homo sapiens]
          Length = 1462

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 59/225 (26%), Positives = 87/225 (38%), Gaps = 52/225 (23%)

Query: 318 VGALSWN--HFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCS 375
           V +L W+    +L+ G   G V   + +  + H   L H   +  L+WSP G  L SG  
Sbjct: 64  VASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHTMPLTHTADITVLRWSPSGNCLLSGDR 123

Query: 376 DGLLTIWPHDPGASAQGQPL------KVITQ--------------------STAVKAMDW 409
            G+L +W  D     QG PL      K +T                     S   KA+D 
Sbjct: 124 LGVLLLWRLDQRGRVQGTPLLKHEYGKHLTHCIFRLPPPGEDLVQLAKAAVSGDEKALDM 183

Query: 410 CPWQ---SGVLAIGG---------GMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKT 457
             W+   SG L   G          + DG +H +D   GK+ Q  S +S I  L ++ K 
Sbjct: 184 FNWKKSSSGSLLKMGSHEGLLFFVSLMDGTVHYVD-EKGKTTQVVSADSTIQMLFYMEKR 242

Query: 458 KEIATGQGTPKNDVTVWTCP---------TVSRSGHRGRVLHLAL 493
           + +     T    ++++T P          V  SG  GR   +AL
Sbjct: 243 EALVV--VTENLRLSLYTVPPEGKAEEVMKVKLSGKTGRRADIAL 285


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 51/235 (21%), Positives = 96/235 (40%), Gaps = 14/235 (5%)

Query: 285 GTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWN--HFILSSGSRLGRVYHHDV 342
           G  +A G+ +   +LW V T K      GH + +  LS+N    ++++GS        D+
Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206

Query: 343 RVAQHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQS 401
           +  +  V TLR H   + +L ++  G  + +G  D  + +W  D G     + + ++   
Sbjct: 207 QNGEE-VYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTG-----RKVNILIGH 260

Query: 402 TAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQT-PSTNSQICSLIWLPKTKEI 460
            A  +     W   ++  G    D    + D   GK + T    + +I    +    K I
Sbjct: 261 CAEISSASFNWDCSLILTGS--MDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLI 318

Query: 461 ATGQ--GTPKNDVTVWTCPTVSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
           AT    GT +              GH G +  ++ +P    + + ++D TA +W+
Sbjct: 319 ATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373



 Score = 33.1 bits (74), Expect = 0.62
 Identities = 43/216 (19%), Positives = 85/216 (39%), Gaps = 12/216 (5%)

Query: 262 NGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGAL 321
           NG E   L      I S+S+   G  +  G+ +  V +WD  T +++  ++GH + + + 
Sbjct: 208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSA 267

Query: 322 S--WNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLL 379
           S  W+  ++ +GS        D    +       H   +    +   G+L+++  +DG  
Sbjct: 268 SFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTA 327

Query: 380 TIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSI 439
            I+     A+ +    K+      +  + + P  + +L    G  D    I D   G+ +
Sbjct: 328 RIF----SAATRKCIAKLEGHEGEISKISFNPQGNHLLT---GSSDKTARIWDAQTGQCL 380

Query: 440 QT-PSTNSQICSLIWLPKTKEIATGQGTPKNDVTVW 474
           Q       +I S  +  K   + T  G+  N   +W
Sbjct: 381 QVLEGHTDEIFSCAFNYKGNIVIT--GSKDNTCRIW 414


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 48/228 (21%), Positives = 96/228 (42%), Gaps = 19/228 (8%)

Query: 291 GTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVG 350
           G+++  +++W+  T + +  + GH S V  +  +   + SGSR   +   D+   Q    
Sbjct: 319 GSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHV 378

Query: 351 TLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWC 410
            + H  AV  +++  DGR + SG  D ++ +W  DP        L+  T        D  
Sbjct: 379 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVW--DPETETCLHTLQGHTNRVYSLQFD-- 432

Query: 411 PWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKND 470
               G+  + G + D  + + D+  G  I T + +  + S + L   K+     G   + 
Sbjct: 433 ----GIHVVSGSL-DTSIRVWDVETGNCIHTLTGHQSLTSGMEL---KDNILVSGNADST 484

Query: 471 VTVW-----TCPTVSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
           V +W      C    +  ++ +     L  ++  V +++ DGT  +W+
Sbjct: 485 VKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWD 532



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 34/144 (23%), Positives = 66/144 (45%), Gaps = 9/144 (6%)

Query: 242 QNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWD 301
           + +V+ A    V +W+ E    +    L    N + S+ +  +G  +  G+ +  +++WD
Sbjct: 394 RRVVSGAYDFMVKVWDPETETCLHT--LQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 449

Query: 302 VVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVA---QHHVGTLRHKQAV 358
           V T   +  + GH S+   +     IL SG+    V   D++     Q   G  +H+ AV
Sbjct: 450 VETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV 509

Query: 359 CALKWSPDGRLLSSGCSDGLLTIW 382
             L+++ +  + SS   DG + +W
Sbjct: 510 TCLQFNKNFVITSS--DDGTVKLW 531



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 30/124 (24%), Positives = 58/124 (46%), Gaps = 3/124 (2%)

Query: 269 LSLTCNYISSVSWIK-EGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFI 327
           L +   ++++V  ++ +G  +  G  +  V++WD  T+  L  + GH + V +L ++   
Sbjct: 376 LHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH 435

Query: 328 LSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPG 387
           + SGS    +   DV    + + TL   Q++ +     D  +L SG +D  + IW    G
Sbjct: 436 VVSGSLDTSIRVWDVETG-NCIHTLTGHQSLTSGMELKD-NILVSGNADSTVKIWDIKTG 493

Query: 388 ASAQ 391
              Q
Sbjct: 494 QCLQ 497


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 48/228 (21%), Positives = 96/228 (42%), Gaps = 19/228 (8%)

Query: 291 GTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVG 350
           G+++  +++W+  T + +  + GH S V  +  +   + SGSR   +   D+   Q    
Sbjct: 437 GSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHV 496

Query: 351 TLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWC 410
            + H  AV  +++  DGR + SG  D ++ +W  DP        L+  T        D  
Sbjct: 497 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVW--DPETETCLHTLQGHTNRVYSLQFD-- 550

Query: 411 PWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKND 470
               G+  + G + D  + + D+  G  I T + +  + S + L   K+     G   + 
Sbjct: 551 ----GIHVVSGSL-DTSIRVWDVETGNCIHTLTGHQSLTSGMEL---KDNILVSGNADST 602

Query: 471 VTVW-----TCPTVSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
           V +W      C    +  ++ +     L  ++  V +++ DGT  +W+
Sbjct: 603 VKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWD 650



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 34/144 (23%), Positives = 66/144 (45%), Gaps = 9/144 (6%)

Query: 242 QNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWD 301
           + +V+ A    V +W+ E    +    L    N + S+ +  +G  +  G+ +  +++WD
Sbjct: 512 RRVVSGAYDFMVKVWDPETETCLHT--LQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 567

Query: 302 VVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVA---QHHVGTLRHKQAV 358
           V T   +  + GH S+   +     IL SG+    V   D++     Q   G  +H+ AV
Sbjct: 568 VETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV 627

Query: 359 CALKWSPDGRLLSSGCSDGLLTIW 382
             L+++ +  + SS   DG + +W
Sbjct: 628 TCLQFNKNFVITSS--DDGTVKLW 649



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 30/124 (24%), Positives = 58/124 (46%), Gaps = 3/124 (2%)

Query: 269 LSLTCNYISSVSWIK-EGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFI 327
           L +   ++++V  ++ +G  +  G  +  V++WD  T+  L  + GH + V +L ++   
Sbjct: 494 LHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH 553

Query: 328 LSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPG 387
           + SGS    +   DV    + + TL   Q++ +     D  +L SG +D  + IW    G
Sbjct: 554 VVSGSLDTSIRVWDVETG-NCIHTLTGHQSLTSGMELKD-NILVSGNADSTVKIWDIKTG 611

Query: 388 ASAQ 391
              Q
Sbjct: 612 QCLQ 615


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 48/228 (21%), Positives = 96/228 (42%), Gaps = 19/228 (8%)

Query: 291 GTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVG 350
           G+++  +++W+  T + +  + GH S V  +  +   + SGSR   +   D+   Q    
Sbjct: 357 GSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHV 416

Query: 351 TLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWC 410
            + H  AV  +++  DGR + SG  D ++ +W  DP        L+  T        D  
Sbjct: 417 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVW--DPETETCLHTLQGHTNRVYSLQFD-- 470

Query: 411 PWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKND 470
               G+  + G + D  + + D+  G  I T + +  + S + L   K+     G   + 
Sbjct: 471 ----GIHVVSGSL-DTSIRVWDVETGNCIHTLTGHQSLTSGMEL---KDNILVSGNADST 522

Query: 471 VTVW-----TCPTVSRSGHRGRVLHLALSPDQTRVFSAAADGTASVWN 513
           V +W      C    +  ++ +     L  ++  V +++ DGT  +W+
Sbjct: 523 VKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWD 570



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 34/144 (23%), Positives = 66/144 (45%), Gaps = 9/144 (6%)

Query: 242 QNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWD 301
           + +V+ A    V +W+ E    +    L    N + S+ +  +G  +  G+ +  +++WD
Sbjct: 432 RRVVSGAYDFMVKVWDPETETCLHT--LQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 487

Query: 302 VVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVA---QHHVGTLRHKQAV 358
           V T   +  + GH S+   +     IL SG+    V   D++     Q   G  +H+ AV
Sbjct: 488 VETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV 547

Query: 359 CALKWSPDGRLLSSGCSDGLLTIW 382
             L+++ +  + SS   DG + +W
Sbjct: 548 TCLQFNKNFVITSS--DDGTVKLW 569



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 30/124 (24%), Positives = 58/124 (46%), Gaps = 3/124 (2%)

Query: 269 LSLTCNYISSVSWIK-EGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFI 327
           L +   ++++V  ++ +G  +  G  +  V++WD  T+  L  + GH + V +L ++   
Sbjct: 414 LHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH 473

Query: 328 LSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPG 387
           + SGS    +   DV    + + TL   Q++ +     D  +L SG +D  + IW    G
Sbjct: 474 VVSGSLDTSIRVWDVETG-NCIHTLTGHQSLTSGMELKD-NILVSGNADSTVKIWDIKTG 531

Query: 388 ASAQ 391
              Q
Sbjct: 532 QCLQ 535


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.129    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,393,068
Number of Sequences: 37866
Number of extensions: 896183
Number of successful extensions: 3932
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 106
Number of HSP's successfully gapped in prelim test: 125
Number of HSP's that attempted gapping in prelim test: 2841
Number of HSP's gapped (non-prelim): 937
length of query: 515
length of database: 18,247,518
effective HSP length: 107
effective length of query: 408
effective length of database: 14,195,856
effective search space: 5791909248
effective search space used: 5791909248
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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