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Search of human proteins with 22749183
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22749183 leucine rich repeat and Ig domain containing 2
[Homo sapiens]
(606 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 1213 0.0
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 752 0.0
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 661 0.0
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 456 e-128
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 179 9e-45
gi|51317373 netrin-G1 ligand [Homo sapiens] 177 2e-44
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 171 1e-42
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 171 1e-42
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 171 1e-42
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 168 1e-41
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens] 167 3e-41
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 167 3e-41
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 167 3e-41
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 162 6e-40
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 159 7e-39
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 159 7e-39
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 153 4e-37
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 153 4e-37
gi|198041768 synleurin [Homo sapiens] 140 3e-33
gi|55741571 leucine rich repeat and fibronectin type III domain ... 140 3e-33
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 140 3e-33
gi|149773484 leucine rich repeat and fibronectin type III domain... 138 1e-32
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 138 1e-32
gi|31542244 leucine rich repeat and fibronectin type III domain ... 137 4e-32
gi|225579152 insulin-like growth factor binding protein, acid la... 136 6e-32
gi|4826772 insulin-like growth factor binding protein, acid labi... 136 6e-32
gi|11321571 slit homolog 3 [Homo sapiens] 136 6e-32
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 135 1e-31
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 134 2e-31
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 132 1e-30
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 1213 bits (3138), Expect = 0.0
Identities = 606/606 (100%), Positives = 606/606 (100%)
Query: 1 MLHTAISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETK 60
MLHTAISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETK
Sbjct: 1 MLHTAISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETK 60
Query: 61 ILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLV 120
ILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLV
Sbjct: 61 ILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLV 120
Query: 121 PLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLE 180
PLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLE
Sbjct: 121 PLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLE 180
Query: 181 QLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDM 240
QLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDM
Sbjct: 181 QLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDM 240
Query: 241 MPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQ 300
MPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQ
Sbjct: 241 MPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQ 300
Query: 301 ELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACD 360
ELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACD
Sbjct: 301 ELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACD 360
Query: 361 CRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHL 420
CRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHL
Sbjct: 361 CRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHL 420
Query: 421 LVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGM 480
LVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGM
Sbjct: 421 LVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGM 480
Query: 481 YVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKT 540
YVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKT
Sbjct: 481 YVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKT 540
Query: 541 ILVSTAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRR 600
ILVSTAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRR
Sbjct: 541 ILVSTAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRR 600
Query: 601 FNMKMI 606
FNMKMI
Sbjct: 601 FNMKMI 606
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 752 bits (1942), Expect = 0.0
Identities = 365/603 (60%), Positives = 468/603 (77%), Gaps = 4/603 (0%)
Query: 6 ISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLS 65
++CWQP L L + + GS GCP RCECSAQ+++V CHR+R +A+PEGIP ET++LDL
Sbjct: 20 LACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLG 79
Query: 66 KNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVF 125
KNR+K++N +EF S+P LEE++L++NI++ VEPGAFNNLFNLR+L L+ NRLKL+PLGVF
Sbjct: 80 KNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVF 139
Query: 126 TGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLE 185
TGLSNLTKLDISENKIVILLDYMFQDL+NLKSLEVGDNDLVYISHRAFSGL SLEQLTLE
Sbjct: 140 TGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLE 199
Query: 186 KCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANS 245
KCNLT++PTEALSHL LI L L+HLNIN + Y+FKRL+ LK LEI +WP LD M N
Sbjct: 200 KCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNC 259
Query: 246 LYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIV 305
LYGLNLTSLS+T+ NL+ VP+LA +HLVYL LNLSYNPISTIE M +L+RLQE+ +V
Sbjct: 260 LYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLV 319
Query: 306 GAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLW 365
G QL +EP++F+GL +LRVLNVS N L TLEE+VF S LE L +++NPLACDCRLLW
Sbjct: 320 GGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLW 379
Query: 366 ILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEG 425
+ +R+ L F QQP CA P+ ++ + FKDF L YFTC++ +IR++K Q + VDEG
Sbjct: 380 VFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEG 439
Query: 426 QTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIA 485
TVQ C ADGDP P I W++PR+ ++ KSNGR TV DGTLE+R+AQ QD+G Y+CIA
Sbjct: 440 HTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIA 499
Query: 486 SNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDS-NDTISNGTNANT-FSLDLKTILV 543
+NA GND+ A L V+ ++ D N+T ++++ + +N T A F D+KT+++
Sbjct: 500 ANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLII 559
Query: 544 STAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRRFNM 603
+T MG +FLGVVLFC +LLF+WSRGKG K++I++EYVPRK++ + + PR+FNM
Sbjct: 560 ATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSAD--APRKFNM 617
Query: 604 KMI 606
KMI
Sbjct: 618 KMI 620
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 661 bits (1705), Expect = 0.0
Identities = 339/603 (56%), Positives = 439/603 (72%), Gaps = 13/603 (2%)
Query: 6 ISCWQPFLGLAVVLIFMGSTI--GCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILD 63
++CW L L ++L+ GCPARCEC+ Q ++V+C RRRL A+P+GIP ET++L+
Sbjct: 1 MTCWLCVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLE 60
Query: 64 LSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLG 123
LS+NR++ +NP + + P LEE+DLS+N IA+VEPGAF NL LR LRL+GN+LKL+P G
Sbjct: 61 LSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPG 120
Query: 124 VFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLT 183
VFT L NLT LD+SENK+VILLDY FQDLH+L+ LEVGDNDLV++S RAF+GLL+LE+LT
Sbjct: 121 VFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELT 180
Query: 184 LEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPA 243
LE+CNLTA+ E+L HLRSL +L L+HL I ++ F+RL L HLEID WPLL+ + A
Sbjct: 181 LERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAA 240
Query: 244 NSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELH 303
SL GLNLTSLSVT+TN++ VP A +H +LT LNLS+NPIST+ G F DL+RL+ELH
Sbjct: 241 GSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELH 300
Query: 304 IVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRL 363
+ GA L +EP +F GLR +R+LN+S NLL TLEE+ F S LE L ++ NPLACDCRL
Sbjct: 301 LAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRL 360
Query: 364 LWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVD 423
LWI+QR+ TL F G+ P CA P +R + ++ + L YF C+KPKIRE++LQ +
Sbjct: 361 LWIVQRRKTLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTAT 420
Query: 424 EGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVC 483
G+ V+ C A+G+P P ++WVTP+ R +T S GRA VL GTLEI+ A+ QDSG Y C
Sbjct: 421 AGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEIQDARPQDSGTYTC 480
Query: 484 IASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKTILV 543
+ASNA GNDT+ A+LTV+ + ANRTP N+T++ A LDL TILV
Sbjct: 481 VASNAGGNDTYFATLTVRPEPA-----ANRTP--GEAHNETLA----ALRAPLDLTTILV 529
Query: 544 STAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRRFNM 603
STAMGC TFLGVVLFCF+LLFVWSRG+G+HKN+ +EY RK +G G R+FNM
Sbjct: 530 STAMGCITFLGVVLFCFVLLFVWSRGRGQHKNNFSVEYSFRKVDGPAAAAGQGGARKFNM 589
Query: 604 KMI 606
KMI
Sbjct: 590 KMI 592
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 456 bits (1173), Expect = e-128
Identities = 252/581 (43%), Positives = 356/581 (61%), Gaps = 13/581 (2%)
Query: 9 WQPFLGLAVVLIFMGSTIG-CPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKN 67
W P+ L +L+ G + G CPA C+C++Q ++V C R+L A+P G+P++T++LDLS N
Sbjct: 11 WPPWPPLLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGN 70
Query: 68 RLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTG 127
RL + LL+E+DLS N ++ +EPGAF+ L +L +LRL+GNRL+++ GVF+G
Sbjct: 71 RLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSG 130
Query: 128 LSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKC 187
LS LT LD+ N+IV+ LD F +L +L+ LEVGDN LV+++ AF+GL L LTLE+C
Sbjct: 131 LSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERC 190
Query: 188 NLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLY 247
NL+ VP AL+ L +L++L L+ L+I +P A + L LK LEI WP L+ + SL
Sbjct: 191 NLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLV 250
Query: 248 GLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGA 307
GLNL+SL++T NLS+VPF A HL +L L+LS NPIS I A S L+RLQEL + GA
Sbjct: 251 GLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGA 310
Query: 308 QLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWIL 367
L +I H+F GL +L+V+ N L+TLEE F SP L L ++ NPL CDCRLLW+L
Sbjct: 311 CLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLL 370
Query: 368 QRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQT 427
+ + L FG P CAGP ++ +S K+F +FTCK IR+ + ++ +EG
Sbjct: 371 RLRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGH 430
Query: 428 VQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASN 487
CS DGDP P +SW+ P ++ GR VL DGTLEIR Q +D G YVC+ SN
Sbjct: 431 AVFSCSGDGDPAPTVSWMRPHGAWLGRA--GRVRVLEDGTLEIRSVQLRDRGAYVCVVSN 488
Query: 488 AAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKTILVSTAM 547
AGND+ L V P T S+ I+ F LD + + + A+
Sbjct: 489 VAGNDSLRTWLEV----------IQVEPPNGTLSDPNITVPGIPGPFFLDSRGVAMVLAV 538
Query: 548 GCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNG 588
G FL V CF L+ +WS+GKG+ K+ + ++V + +G
Sbjct: 539 GFLPFLTSVTLCFGLIALWSKGKGRVKHHMTFDFVAPRPSG 579
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 179 bits (453), Expect = 9e-45
Identities = 140/478 (29%), Positives = 212/478 (44%), Gaps = 86/478 (17%)
Query: 28 CPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEID 87
CP C CS Q V C RR L +P IP+ T+ L+L +N ++ + + F LE +
Sbjct: 57 CPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQ 116
Query: 88 LSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDY 147
LS N++ +E GAFN L +L +L L NRL VP F LS L +L + N I + Y
Sbjct: 117 LSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSY 176
Query: 148 MFQDLHNLKSLEVGD-NDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISL 206
F + +L+ L++G+ L YIS AF GL++L L L CNL +P +L +L+ L
Sbjct: 177 AFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIP-----NLTALVRL 231
Query: 207 HLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGL-NLTSLSVTNTNLSTVP 265
L+ N LD++ S GL +L L + + ++T+
Sbjct: 232 EELELSGNR----------------------LDLIRPGSFQGLTSLRKLWLMHAQVATIE 269
Query: 266 FLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRV 325
AF L L LNLS+N + ++ +F+ L RL+ +H
Sbjct: 270 RNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVH---------------------- 307
Query: 326 LNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWI--LQRQPTLQFGGQQPMCA 383
+N+NP C+C +LW+ ++ C
Sbjct: 308 --------------------------LNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCH 341
Query: 384 GPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVIS 443
P ++ R + + +FTC P I E L V EG +L+C G ++
Sbjct: 342 APAGLKGRYIGELDQS----HFTCYAPVIVEPPTD-LNVTEGMAAELKCRT-GTSMTSVN 395
Query: 444 WVTPRRRFITTKS-NGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
W+TP +T S R +VL DGTL QD+G Y C+ +N+AGN T +A+L V
Sbjct: 396 WLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 177 bits (450), Expect = 2e-44
Identities = 136/438 (31%), Positives = 217/438 (49%), Gaps = 18/438 (4%)
Query: 117 LKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGL 176
L+ VP G+ T N L++ EN+I I+ F+ L +L+ L++ N + I AF+GL
Sbjct: 67 LREVPDGIST---NTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGL 123
Query: 177 LSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWP 236
+L L L LT +P A +L L L L++ I ++P YAF R+ L+ L++
Sbjct: 124 ANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELK 183
Query: 237 LLDMMPANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSD 295
L + + GL NL L++ NL +P L L+ L L+LS N +S I G F
Sbjct: 184 RLSYISEGAFEGLSNLRYLNLAMCNLREIPNLT--PLIKLDELDLSGNHLSAIRPGSFQG 241
Query: 296 LIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNN 355
L+ LQ+L ++ +Q++ IE ++F L+ L +N++ N L L ++F+ LE + +++N
Sbjct: 242 LMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
Query: 356 PLACDCRLLWILQRQPTLQFGGQQ--PMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIR 413
P C+C +LW+ + C P ++ R + YFTC P I
Sbjct: 302 PWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQN----YFTCYAPVIV 357
Query: 414 EKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKS-NGRATVLGDGTLEIRF 472
E L V EG +L+C A V SW+TP +T + R VL DGTL
Sbjct: 358 EPPAD-LNVTEGMAAELKCRASTSLTSV-SWITPNGTVMTHGAYKVRIAVLSDGTLNFTN 415
Query: 473 AQDQDSGMYVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNAN 532
QD+GMY C+ SN+ GN T +A+L V + F Y + + + + + T+ N
Sbjct: 416 VTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNN 475
Query: 533 ---TFSLDLKTILVSTAM 547
T +D +T V+T++
Sbjct: 476 VGPTPVVDWETTNVTTSL 493
Score = 135 bits (339), Expect = 1e-31
Identities = 89/262 (33%), Positives = 140/262 (53%), Gaps = 11/262 (4%)
Query: 28 CPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEID 87
CP+ C CS Q V C R+ L +P+GI T++L+L +N+++ + F LE +
Sbjct: 47 CPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQ 106
Query: 88 LSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDY 147
LS N I +E GAFN L NL +L L NRL +P G F LS L +L + N I + Y
Sbjct: 107 LSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSY 166
Query: 148 MFQDLHNLKSLEVGD-NDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISL 206
F + +L+ L++G+ L YIS AF GL +L L L CNL +P L+ L L L
Sbjct: 167 AFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDEL 224
Query: 207 HLKHLNINNMPVYAFKRLFHLKHLEIDYWPL---LDMMPANSLYGL-NLTSLSVTNTNLS 262
L +++ + +F+ L HL+ L W + + ++ N+ L +L +++ + NL+
Sbjct: 225 DLSGNHLSAIRPGSFQGLMHLQKL----WMIQSQIQVIERNAFDNLQSLVEINLAHNNLT 280
Query: 263 TVPFLAFKHLVYLTHLNLSYNP 284
+P F L +L ++L +NP
Sbjct: 281 LLPHDLFTPLHHLERIHLHHNP 302
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 171 bits (434), Expect = 1e-42
Identities = 133/529 (25%), Positives = 224/529 (42%), Gaps = 64/529 (12%)
Query: 13 LGLAVVLIFMG--STIGCPARCECSA-----------QNKSVSCHRRRLIAIPEGIPIET 59
LGLA+ + + CP C C + +V C+ L+ P +P T
Sbjct: 12 LGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANT 71
Query: 60 KIL-----------------------DLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANV 96
+IL DLS+N L SV P L + L +N + +
Sbjct: 72 QILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTEL 131
Query: 97 EPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLK 156
+ L NL+ L + N L + G F GL NL +L ++ N++ ++ F L NL+
Sbjct: 132 PEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLE 191
Query: 157 SLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNM 216
L +G+N ++ I F L++L L + NLT +P AL L +L S+ + +
Sbjct: 192 ILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKV 251
Query: 217 PVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTN-TNLSTVPFLAFKHLVYL 275
P A +++ +LK L+++ P+ + + L+L L + N L ++ LA +L L
Sbjct: 252 PHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDL 311
Query: 276 THLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLET 335
+ + NP +L I P++F L L L ++ N L
Sbjct: 312 RKIEATNNP-----------------------RLSYIHPNAFFRLPKLESLMLNSNALSA 348
Query: 336 LEENVFSSPRALEVLSINNNPLACDCRLLWILQRQPTLQFGGQQPM-CAGPDTIRERSFK 394
L S L+ +SI++NP+ CDC + W+ + ++F + C P + ++ +
Sbjct: 349 LYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVR 408
Query: 395 DFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPR-RRFIT 453
H C E +L V+ G V C A +PQP I W+TP ++ +
Sbjct: 409 QVHFR--DMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLP 466
Query: 454 TKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKG 502
+ V +GTL+I ++ G+Y CIA+N G D + + V G
Sbjct: 467 NTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDG 515
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 171 bits (434), Expect = 1e-42
Identities = 133/529 (25%), Positives = 224/529 (42%), Gaps = 64/529 (12%)
Query: 13 LGLAVVLIFMG--STIGCPARCECSA-----------QNKSVSCHRRRLIAIPEGIPIET 59
LGLA+ + + CP C C + +V C+ L+ P +P T
Sbjct: 12 LGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANT 71
Query: 60 KIL-----------------------DLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANV 96
+IL DLS+N L SV P L + L +N + +
Sbjct: 72 QILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTEL 131
Query: 97 EPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLK 156
+ L NL+ L + N L + G F GL NL +L ++ N++ ++ F L NL+
Sbjct: 132 PEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLE 191
Query: 157 SLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNM 216
L +G+N ++ I F L++L L + NLT +P AL L +L S+ + +
Sbjct: 192 ILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKV 251
Query: 217 PVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTN-TNLSTVPFLAFKHLVYL 275
P A +++ +LK L+++ P+ + + L+L L + N L ++ LA +L L
Sbjct: 252 PHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDL 311
Query: 276 THLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLET 335
+ + NP +L I P++F L L L ++ N L
Sbjct: 312 RKIEATNNP-----------------------RLSYIHPNAFFRLPKLESLMLNSNALSA 348
Query: 336 LEENVFSSPRALEVLSINNNPLACDCRLLWILQRQPTLQFGGQQPM-CAGPDTIRERSFK 394
L S L+ +SI++NP+ CDC + W+ + ++F + C P + ++ +
Sbjct: 349 LYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVR 408
Query: 395 DFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPR-RRFIT 453
H C E +L V+ G V C A +PQP I W+TP ++ +
Sbjct: 409 QVHFR--DMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLP 466
Query: 454 TKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKG 502
+ V +GTL+I ++ G+Y CIA+N G D + + V G
Sbjct: 467 NTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDG 515
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 171 bits (434), Expect = 1e-42
Identities = 133/529 (25%), Positives = 224/529 (42%), Gaps = 64/529 (12%)
Query: 13 LGLAVVLIFMG--STIGCPARCECSA-----------QNKSVSCHRRRLIAIPEGIPIET 59
LGLA+ + + CP C C + +V C+ L+ P +P T
Sbjct: 12 LGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANT 71
Query: 60 KIL-----------------------DLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANV 96
+IL DLS+N L SV P L + L +N + +
Sbjct: 72 QILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTEL 131
Query: 97 EPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLK 156
+ L NL+ L + N L + G F GL NL +L ++ N++ ++ F L NL+
Sbjct: 132 PEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLE 191
Query: 157 SLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNM 216
L +G+N ++ I F L++L L + NLT +P AL L +L S+ + +
Sbjct: 192 ILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKV 251
Query: 217 PVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTN-TNLSTVPFLAFKHLVYL 275
P A +++ +LK L+++ P+ + + L+L L + N L ++ LA +L L
Sbjct: 252 PHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDL 311
Query: 276 THLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLET 335
+ + NP +L I P++F L L L ++ N L
Sbjct: 312 RKIEATNNP-----------------------RLSYIHPNAFFRLPKLESLMLNSNALSA 348
Query: 336 LEENVFSSPRALEVLSINNNPLACDCRLLWILQRQPTLQFGGQQPM-CAGPDTIRERSFK 394
L S L+ +SI++NP+ CDC + W+ + ++F + C P + ++ +
Sbjct: 349 LYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVR 408
Query: 395 DFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPR-RRFIT 453
H C E +L V+ G V C A +PQP I W+TP ++ +
Sbjct: 409 QVHFR--DMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLP 466
Query: 454 TKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKG 502
+ V +GTL+I ++ G+Y CIA+N G D + + V G
Sbjct: 467 NTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDG 515
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 168 bits (426), Expect = 1e-41
Identities = 136/478 (28%), Positives = 209/478 (43%), Gaps = 87/478 (18%)
Query: 28 CPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEID 87
CP+ C CS Q V C RR L +P+GIP T+ L+L +N ++ + + F LE +
Sbjct: 46 CPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQ 105
Query: 88 LSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDY 147
L N I +E GAFN L +L +L L N L ++P G F LS L +L + N I + Y
Sbjct: 106 LGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSY 165
Query: 148 MFQDLHNLKSLEVGD-NDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISL 206
F + +L L++G+ L YIS AF GL +L+ L L CN+ +P +L L+ L
Sbjct: 166 AFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMP-----NLTPLVGL 220
Query: 207 HLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGL-NLTSLSVTNTNLSTVP 265
++ N+ P ++ P S +GL +L L V N+ +S +
Sbjct: 221 EELEMSGNHFP---------------------EIRP-GSFHGLSSLKKLWVMNSQVSLIE 258
Query: 266 FLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRV 325
AF L L LNL++N +S++ +F+ L L ELH
Sbjct: 259 RNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELH---------------------- 296
Query: 326 LNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWIL--QRQPTLQFGGQQPMCA 383
+++NP CDC +LW+ R+ C
Sbjct: 297 --------------------------LHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCH 330
Query: 384 GPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVIS 443
P +R R + + F C P I + + L + EG+ +L+C P +
Sbjct: 331 APMHMRGRYLVEVDQAS----FQCSAPFIMDAP-RDLNISEGRMAELKCRT--PPMSSVK 383
Query: 444 WVTPRRRFITTKS-NGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
W+ P ++ S + R +VL DGTL D+G+Y C+ +N AGN +A L V
Sbjct: 384 WLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNV 441
>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
Length = 716
Score = 167 bits (423), Expect = 3e-41
Identities = 151/579 (26%), Positives = 244/579 (42%), Gaps = 76/579 (13%)
Query: 6 ISCWQPFLGLAVVLIFMGSTIG--CPARCECSA-----------QNKSVSCHRRRLIAIP 52
I+ Q LGL + + S CP C C + +V C+ RL IP
Sbjct: 8 IAACQLVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIP 67
Query: 53 EGIPIETKIL-----------------------DLSKNRLKSVNPEEFISYPLLEEIDLS 89
+ +T++L D S+N ++ + L + L
Sbjct: 68 SNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLE 127
Query: 90 DNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMF 149
+N I + +L NL+ L + N++ + F GL NL +L ++ NK+ ++ F
Sbjct: 128 ENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWF 187
Query: 150 QDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLK 209
NL+ L +G+N ++ I F L +L L L LT +P AL L SL SL
Sbjct: 188 DSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFY 247
Query: 210 HLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNT-NLSTVPFLA 268
+ +P A +++ +LK L+++ P+ + + L L L + N L +V A
Sbjct: 248 DNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYA 307
Query: 269 FKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNV 328
+L LT L + NP +L I +F+ + L L +
Sbjct: 308 LDNLPELTKLEATNNP-----------------------KLSYIHRLAFRSVPALESLML 344
Query: 329 SQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQRQPTLQFGGQQPM---CAGP 385
+ N L + + S L +SI++NPL CDC + WI + ++F +P+ CA P
Sbjct: 345 NNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRF--MEPLSMFCAMP 402
Query: 386 DTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWV 445
+ K+ S C + L VD G TV L+C A +P+P I WV
Sbjct: 403 PEYKGHQVKEVLIQDSS--EQCLPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWV 460
Query: 446 TPRRRFITTKS-NGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFA 504
TP IT ++ + + + +GTLEI Q +DSG Y C+A N G DT A++ V G
Sbjct: 461 TPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKVNGTL 520
Query: 505 SDRF----LYANRTPMYMTDSNDTISNGTNANTFSLDLK 539
D +Y +T + + +S N+N + +LK
Sbjct: 521 LDGTQVLKIYVKQTESH----SILVSWKVNSNVMTSNLK 555
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 167 bits (423), Expect = 3e-41
Identities = 140/518 (27%), Positives = 224/518 (43%), Gaps = 73/518 (14%)
Query: 26 IGCPARCECSA-----------QNKSVSCHRRRLIAIPEGIPIETKIL------------ 62
+ CP +C C + +V C+ L A+P +P T+ L
Sbjct: 27 VPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQ 86
Query: 63 ------------DLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSL 110
DLS+N +F + P L + L +N + +E +F L +L+ L
Sbjct: 87 SELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQEL 146
Query: 111 RLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISH 170
L N+L + F+GLSNL +L ++ N + + F+ L NL+ L +G N + I
Sbjct: 147 YLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILD 206
Query: 171 RAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHL 230
F L +L L L NL + AL L+SL SL + +P A +++ LK L
Sbjct: 207 MNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFL 266
Query: 231 EIDYWPLLDMMPANSLYGLNLTSLSVTN-TNLSTVPFLAFKHLVYLTHLNLSYNPISTIE 289
+++ PL + P + L+L L + N L ++ A +L LT L+++ NP
Sbjct: 267 DLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNP----- 321
Query: 290 AGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEV 349
+L I P +F L + L ++ N L L + S L+
Sbjct: 322 ------------------RLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQE 363
Query: 350 LSINNNPLACDCRLLWILQRQPTLQF-GGQQPMCAGPD-----TIRERSFKDFHSTALSF 403
+ ++ NP+ CDC + W ++F Q +CA P +RE F++ L
Sbjct: 364 VGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPL 423
Query: 404 YFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRA-TV 462
P+ LQ V G+++ L C A +P+P I WVTP +T GR V
Sbjct: 424 I----SPRSFPPSLQ---VASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRV 476
Query: 463 LGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
+GTLE+R +++G+Y C+A N G DT T S+ V
Sbjct: 477 YPEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 167 bits (423), Expect = 3e-41
Identities = 140/518 (27%), Positives = 224/518 (43%), Gaps = 73/518 (14%)
Query: 26 IGCPARCECSA-----------QNKSVSCHRRRLIAIPEGIPIETKIL------------ 62
+ CP +C C + +V C+ L A+P +P T+ L
Sbjct: 27 VPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQ 86
Query: 63 ------------DLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSL 110
DLS+N +F + P L + L +N + +E +F L +L+ L
Sbjct: 87 SELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQEL 146
Query: 111 RLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISH 170
L N+L + F+GLSNL +L ++ N + + F+ L NL+ L +G N + I
Sbjct: 147 YLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILD 206
Query: 171 RAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHL 230
F L +L L L NL + AL L+SL SL + +P A +++ LK L
Sbjct: 207 MNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFL 266
Query: 231 EIDYWPLLDMMPANSLYGLNLTSLSVTN-TNLSTVPFLAFKHLVYLTHLNLSYNPISTIE 289
+++ PL + P + L+L L + N L ++ A +L LT L+++ NP
Sbjct: 267 DLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNP----- 321
Query: 290 AGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEV 349
+L I P +F L + L ++ N L L + S L+
Sbjct: 322 ------------------RLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQE 363
Query: 350 LSINNNPLACDCRLLWILQRQPTLQF-GGQQPMCAGPD-----TIRERSFKDFHSTALSF 403
+ ++ NP+ CDC + W ++F Q +CA P +RE F++ L
Sbjct: 364 VGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPL 423
Query: 404 YFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRA-TV 462
P+ LQ V G+++ L C A +P+P I WVTP +T GR V
Sbjct: 424 I----SPRSFPPSLQ---VASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRV 476
Query: 463 LGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
+GTLE+R +++G+Y C+A N G DT T S+ V
Sbjct: 477 YPEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 162 bits (411), Expect = 6e-40
Identities = 124/408 (30%), Positives = 185/408 (45%), Gaps = 52/408 (12%)
Query: 28 CPARCECSAQNKSVSCHRRRLIAIPEGIP---------------IETKILDLSKNRLKSV 72
CP C+C Q V C L +P IP +ET+ + N K V
Sbjct: 22 CPMGCDCFVQE--VFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVV 79
Query: 73 ---------NPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLG 123
P+ F P LE+++++ + N+ F+NL +L L L N L+ +P G
Sbjct: 80 FLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEG 139
Query: 124 VFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLT 183
+F L+ L L + N++ L +FQ L +LK+L + N L + F L SL+ L
Sbjct: 140 LFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLK 199
Query: 184 LEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEID---------- 233
L L+ +P L SL L L NI+ +P F +LF L+ L +
Sbjct: 200 LSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLS 259
Query: 234 -------------YWPLLDMMPANSL-YGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLN 279
W +L ++PA + L LS+T+ L TV F HL L L
Sbjct: 260 IFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLM 319
Query: 280 LSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEEN 339
LSYN I+ + AG+F DL L +L++ L + P FQ L L +L++S+N L TL E
Sbjct: 320 LSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEG 379
Query: 340 VFSSPRALEVLSINNNPLACDCRLLWILQ--RQPTLQFGGQQPMCAGP 385
+F + L L+++ NP CDC L ++ +Q T + Q CAGP
Sbjct: 380 IFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGP 427
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 159 bits (402), Expect = 7e-39
Identities = 106/355 (29%), Positives = 172/355 (48%), Gaps = 25/355 (7%)
Query: 27 GCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEI 86
GCP+ C CS ++ V C R++A+P +P L + + +N F++ L +
Sbjct: 30 GCPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIAL 88
Query: 87 DLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLD 146
+ N ++ + PGAF NL +LR L L N+L+++P+G+F GL +L L +S N+++ +
Sbjct: 89 RIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQP 148
Query: 147 YMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISL 206
F NLK L++ N L YI AF L+ L +L L K +LT + HL +L L
Sbjct: 149 AHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVL 208
Query: 207 HLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPF 266
L + ++P+ F L +L+ L + + + P NL L ++N ++S +P
Sbjct: 209 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPP 268
Query: 267 LAFKHLVYLTHLNLSYNPISTIEAGMF------------------------SDLIRLQEL 302
F L L L L N + + G+F S+L +LQ L
Sbjct: 269 SIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVL 328
Query: 303 HIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
+ Q+ I P +F GL LR L++ N L+ L+ NVF L+ +S+ NN L
Sbjct: 329 ILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 383
Score = 83.6 bits (205), Expect = 5e-16
Identities = 61/205 (29%), Positives = 101/205 (49%)
Query: 154 NLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNI 213
N SL++ + + ++ F + +L L +EK L+ + A +L SL L L + +
Sbjct: 60 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 119
Query: 214 NNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLV 273
+P+ F+ L L+ L + LL + PA+ NL L + +L +P AF HLV
Sbjct: 120 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV 179
Query: 274 YLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLL 333
LT LNL N ++ I +F L LQ L + +L I +F GL L+ L + QN +
Sbjct: 180 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 239
Query: 334 ETLEENVFSSPRALEVLSINNNPLA 358
L +F + L+ L ++NN ++
Sbjct: 240 GLLSPGLFHNNHNLQRLYLSNNHIS 264
Score = 82.8 bits (203), Expect = 8e-16
Identities = 72/245 (29%), Positives = 114/245 (46%), Gaps = 29/245 (11%)
Query: 44 HRRRLIAIPEGI---PIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGA 100
+ RL IP G + + L L +N++ ++P F + L+ + LS+N I+ + P
Sbjct: 211 YENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSI 270
Query: 101 FNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEV 160
F L L L L GN LK + LG+F + NL +L + +N I L D +F +L L+ L +
Sbjct: 271 FMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLIL 330
Query: 161 GDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYA 220
N + +IS AF+GL L +L+L T AL L +
Sbjct: 331 SRNQISFISPGAFNGLTELRELSLH--------TNALQDLDGNV---------------- 366
Query: 221 FKRLFHLKHLEIDYWPLLDMMPANSLYGLN-LTSLSVTNTNLSTVPFLAFKHLVYLTHLN 279
F+ L +L+++ + L +P N +N L ++ + N L +P F HL L L
Sbjct: 367 FRMLANLQNISLQN-NRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELR 425
Query: 280 LSYNP 284
L NP
Sbjct: 426 LYDNP 430
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 159 bits (402), Expect = 7e-39
Identities = 106/355 (29%), Positives = 172/355 (48%), Gaps = 25/355 (7%)
Query: 27 GCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEI 86
GCP+ C CS ++ V C R++A+P +P L + + +N F++ L +
Sbjct: 24 GCPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIAL 82
Query: 87 DLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLD 146
+ N ++ + PGAF NL +LR L L N+L+++P+G+F GL +L L +S N+++ +
Sbjct: 83 RIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQP 142
Query: 147 YMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISL 206
F NLK L++ N L YI AF L+ L +L L K +LT + HL +L L
Sbjct: 143 AHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVL 202
Query: 207 HLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPF 266
L + ++P+ F L +L+ L + + + P NL L ++N ++S +P
Sbjct: 203 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPP 262
Query: 267 LAFKHLVYLTHLNLSYNPISTIEAGMF------------------------SDLIRLQEL 302
F L L L L N + + G+F S+L +LQ L
Sbjct: 263 SIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVL 322
Query: 303 HIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
+ Q+ I P +F GL LR L++ N L+ L+ NVF L+ +S+ NN L
Sbjct: 323 ILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 377
Score = 83.6 bits (205), Expect = 5e-16
Identities = 61/205 (29%), Positives = 101/205 (49%)
Query: 154 NLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNI 213
N SL++ + + ++ F + +L L +EK L+ + A +L SL L L + +
Sbjct: 54 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 113
Query: 214 NNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLV 273
+P+ F+ L L+ L + LL + PA+ NL L + +L +P AF HLV
Sbjct: 114 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV 173
Query: 274 YLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLL 333
LT LNL N ++ I +F L LQ L + +L I +F GL L+ L + QN +
Sbjct: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233
Query: 334 ETLEENVFSSPRALEVLSINNNPLA 358
L +F + L+ L ++NN ++
Sbjct: 234 GLLSPGLFHNNHNLQRLYLSNNHIS 258
Score = 82.8 bits (203), Expect = 8e-16
Identities = 72/245 (29%), Positives = 114/245 (46%), Gaps = 29/245 (11%)
Query: 44 HRRRLIAIPEGI---PIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGA 100
+ RL IP G + + L L +N++ ++P F + L+ + LS+N I+ + P
Sbjct: 205 YENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSI 264
Query: 101 FNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEV 160
F L L L L GN LK + LG+F + NL +L + +N I L D +F +L L+ L +
Sbjct: 265 FMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLIL 324
Query: 161 GDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYA 220
N + +IS AF+GL L +L+L T AL L +
Sbjct: 325 SRNQISFISPGAFNGLTELRELSLH--------TNALQDLDGNV---------------- 360
Query: 221 FKRLFHLKHLEIDYWPLLDMMPANSLYGLN-LTSLSVTNTNLSTVPFLAFKHLVYLTHLN 279
F+ L +L+++ + L +P N +N L ++ + N L +P F HL L L
Sbjct: 361 FRMLANLQNISLQN-NRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELR 419
Query: 280 LSYNP 284
L NP
Sbjct: 420 LYDNP 424
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 153 bits (387), Expect = 4e-37
Identities = 154/525 (29%), Positives = 232/525 (44%), Gaps = 56/525 (10%)
Query: 39 KSVSCHRRRLIAIPEGIPIETKI--LDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIA-- 94
+ V + L IP P+ I L L+ NR+ + PE + LE +DLS N I+
Sbjct: 101 REVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL 160
Query: 95 --------------------NVEPGAFNNLFN-LRSLRLKGNRLKLVPLGVFTGLSNLTK 133
++EPG F+NL N L L+L NR+ +P +F L L
Sbjct: 161 QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQH 219
Query: 134 LDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVP 193
L+++ NKI + FQ L LKSL++ N + + AF GL ++E L L+ NLT +
Sbjct: 220 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 279
Query: 194 TEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNL-T 252
L L L LHL IN + A++ L L++ + L + +S GL+L
Sbjct: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTF-NHLSRLDDSSFLGLSLLN 338
Query: 253 SLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPIS-TIEA--GMFSDLIRLQELHIVGAQL 309
+L + N +S + AF+ L L L+L N IS TIE G FS L +L+ L + G ++
Sbjct: 339 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 398
Query: 310 RTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQR 369
R+I +F GL L L++S N + +L+ N FS + L+ L +N + L CDC+L W+ Q
Sbjct: 399 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 458
Query: 370 QPTLQFGG-QQPMCAGPDTIRERSFKDFHSTALSFYFTC---KKPKIREKKLQHLLVDEG 425
F CA P ++ RS F C KP+I + + +G
Sbjct: 459 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDG----FVCDDFPKPQITVQPETQSAI-KG 513
Query: 426 QTVQLECSA--DGDPQPVISWVTPRRRFITTKSNGRATVLGDG--------TLEIRFAQD 475
+ CSA D +W + A + G L +R +
Sbjct: 514 SNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEF 573
Query: 476 QDSGMYVCIASNAAGND-TFTASLTVKGFASDRFLYANRTPMYMT 519
G Y C+ SN G+ + A LTV S +TPM +T
Sbjct: 574 ASEGKYQCVISNHFGSSYSVKAKLTVNMLPS-----FTKTPMDLT 613
Score = 42.0 bits (97), Expect = 0.002
Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 1/82 (1%)
Query: 420 LLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLG-DGTLEIRFAQDQDS 478
L + G +LEC+A G P P I+W R V+ D I + +D
Sbjct: 612 LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 671
Query: 479 GMYVCIASNAAGNDTFTASLTV 500
G+Y C A N+AG+ + A+LTV
Sbjct: 672 GVYSCTAQNSAGSISANATLTV 693
Score = 41.2 bits (95), Expect = 0.003
Identities = 24/79 (30%), Positives = 37/79 (46%), Gaps = 2/79 (2%)
Query: 422 VDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMY 481
V +G+T L+C A G P P ++W + T+ + A G+ L I + D+G Y
Sbjct: 708 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAA--GNQLLIIVDSDVSDAGKY 765
Query: 482 VCIASNAAGNDTFTASLTV 500
C SN G + L+V
Sbjct: 766 TCEMSNTLGTERGNVRLSV 784
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 153 bits (387), Expect = 4e-37
Identities = 154/525 (29%), Positives = 232/525 (44%), Gaps = 56/525 (10%)
Query: 39 KSVSCHRRRLIAIPEGIPIETKI--LDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIA-- 94
+ V + L IP P+ I L L+ NR+ + PE + LE +DLS N I+
Sbjct: 41 REVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL 100
Query: 95 --------------------NVEPGAFNNLFN-LRSLRLKGNRLKLVPLGVFTGLSNLTK 133
++EPG F+NL N L L+L NR+ +P +F L L
Sbjct: 101 QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQH 159
Query: 134 LDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVP 193
L+++ NKI + FQ L LKSL++ N + + AF GL ++E L L+ NLT +
Sbjct: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219
Query: 194 TEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNL-T 252
L L L LHL IN + A++ L L++ + L + +S GL+L
Sbjct: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTF-NHLSRLDDSSFLGLSLLN 278
Query: 253 SLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPIS-TIEA--GMFSDLIRLQELHIVGAQL 309
+L + N +S + AF+ L L L+L N IS TIE G FS L +L+ L + G ++
Sbjct: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338
Query: 310 RTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQR 369
R+I +F GL L L++S N + +L+ N FS + L+ L +N + L CDC+L W+ Q
Sbjct: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 398
Query: 370 QPTLQFGG-QQPMCAGPDTIRERSFKDFHSTALSFYFTC---KKPKIREKKLQHLLVDEG 425
F CA P ++ RS F C KP+I + + +G
Sbjct: 399 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDG----FVCDDFPKPQITVQPETQSAI-KG 453
Query: 426 QTVQLECSA--DGDPQPVISWVTPRRRFITTKSNGRATVLGDG--------TLEIRFAQD 475
+ CSA D +W + A + G L +R +
Sbjct: 454 SNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEF 513
Query: 476 QDSGMYVCIASNAAGND-TFTASLTVKGFASDRFLYANRTPMYMT 519
G Y C+ SN G+ + A LTV S +TPM +T
Sbjct: 514 ASEGKYQCVISNHFGSSYSVKAKLTVNMLPS-----FTKTPMDLT 553
Score = 64.7 bits (156), Expect = 2e-10
Identities = 71/285 (24%), Positives = 130/285 (45%), Gaps = 31/285 (10%)
Query: 104 LFNLRSLRLKGNRLKLVPLGVFTGL-----------------------SNLTKLDISENK 140
LF++ L NRL + + L +N+T L ++ N+
Sbjct: 13 LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNR 72
Query: 141 IVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHL 200
IV +L ++ +L++L++ N++ + AF L L+ L L +T++ +L
Sbjct: 73 IVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPA-LQLKYLYLNSNRVTSMEPGYFDNL 130
Query: 201 -RSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLN-LTSLSVTN 258
+L+ L L I+ +P FK L L+HLE++ + + + + GL L SL +
Sbjct: 131 ANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKN-VDGLTFQGLGALKSLKMQR 188
Query: 259 TNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQ 318
++ + AF L + L L +N ++ I G L+ LQELH+ + I P +++
Sbjct: 189 NGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWE 248
Query: 319 GLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLA--CDC 361
+ L L+++ N L L+++ F L L I NN ++ DC
Sbjct: 249 FCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADC 293
Score = 42.0 bits (97), Expect = 0.002
Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 1/82 (1%)
Query: 420 LLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLG-DGTLEIRFAQDQDS 478
L + G +LEC+A G P P I+W R V+ D I + +D
Sbjct: 552 LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611
Query: 479 GMYVCIASNAAGNDTFTASLTV 500
G+Y C A N+AG+ + A+LTV
Sbjct: 612 GVYSCTAQNSAGSISANATLTV 633
Score = 41.2 bits (95), Expect = 0.003
Identities = 24/79 (30%), Positives = 37/79 (46%), Gaps = 2/79 (2%)
Query: 422 VDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMY 481
V +G+T L+C A G P P ++W + T+ + A G+ L I + D+G Y
Sbjct: 648 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAA--GNQLLIIVDSDVSDAGKY 705
Query: 482 VCIASNAAGNDTFTASLTV 500
C SN G + L+V
Sbjct: 706 TCEMSNTLGTERGNVRLSV 724
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 140 bits (354), Expect = 3e-33
Identities = 115/429 (26%), Positives = 192/429 (44%), Gaps = 61/429 (14%)
Query: 2 LHTAISCWQPFLGLAVVLIFM--GSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIET 59
L ++ C + FL + L+ + +GC + C+ + ++C L +IP+ P T
Sbjct: 4 LQFSLPCLRLFLVVTCYLLLLLHKEILGCSSVCQLCT-GRQINCRNLGLSSIPKNFPEST 62
Query: 60 KILDLSKNRLKSVN------------------------PEEFISYPLLEEIDLSDNIIAN 95
L L+ N + +N P+ F+ L + L++N I
Sbjct: 63 VFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKR 122
Query: 96 VEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNL 155
++PG F L NLR+L L+ N++ VP GVF L ++ L++ N++ +L F + L
Sbjct: 123 LDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVAL 182
Query: 156 KSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINN 215
+ L++ +N+++ IS F L +L L L NLT VP+ A L+SL L L H I
Sbjct: 183 RILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEA 242
Query: 216 MPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYL 275
+ +AFK L NL L + N+ + V F + L
Sbjct: 243 IQPFAFKGL------------------------ANLEYLLLKNSRIRNVTRDGFSGINNL 278
Query: 276 THLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGL-RFLRVLNVSQNLLE 334
HL LS+N + + + FS L L L + ++ +I+ +F+ + L++LN+S N L
Sbjct: 279 KHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLT 338
Query: 335 TLEENVFSSPRALEVLSINNNPLACDCRLL----WILQRQPTLQFGGQQPMCAGPDTIRE 390
L V +L L N+NP C+C+LL W+ TL C P ++R
Sbjct: 339 ALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITLNI-----YCQNPPSMRG 393
Query: 391 RSFKDFHST 399
R+ + + T
Sbjct: 394 RALRYINIT 402
>gi|55741571 leucine rich repeat and fibronectin type III domain
containing 2 [Homo sapiens]
Length = 789
Score = 140 bits (353), Expect = 3e-33
Identities = 103/346 (29%), Positives = 164/346 (47%), Gaps = 29/346 (8%)
Query: 158 LEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMP 217
L +G N +++IS + F+ + L LTL + ++ + + L SL SLHL + ++
Sbjct: 57 LRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLG 116
Query: 218 VYAFKRLFHLKHLEIDYWPLLDMMP-ANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLT 276
+ L +L+HL ++ L + A + L L L ++ NL +P+ + + +V L
Sbjct: 117 EDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLH 176
Query: 277 HLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETL 336
L+L +N + I G F+DL +L L + +L+ + P +++ L
Sbjct: 177 QLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPI----------FARSQASAL 226
Query: 337 EENVFSSPRALEVLSINNNPLACDCRLLWI--LQRQPTLQFGGQQPMCAGPDTIRERSFK 394
F+ P + S NPL C+C LLW+ L+R L+ C P ++ R F
Sbjct: 227 TATPFAPPLSF---SFGGNPLHCNCELLWLRRLERDDDLE------TCGSPGGLKGRYFW 277
Query: 395 DFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITT 454
F C+ P I + LLV EGQ L+C A GDP P+I WV P R +
Sbjct: 278 HVREEE----FVCEPPLITQHT-HKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGN 332
Query: 455 KSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
S R V +GTL+I QDSG + CIA+NAAG T +++
Sbjct: 333 SS--RTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSI 376
Score = 76.6 bits (187), Expect = 6e-14
Identities = 54/193 (27%), Positives = 98/193 (50%), Gaps = 3/193 (1%)
Query: 28 CPARCECSAQNKSVS--CHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEE 85
CP C C ++S+ C + L+ +P I T L L N + ++ ++F + L +
Sbjct: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
Query: 86 IDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILL 145
+ LS N I++++P +F +L +LRSL L NRL + GL NL L ++ N++ +
Sbjct: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
Query: 146 DYMFQD-LHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLI 204
D F+D L L+ L++ N+L + + +++L QL+L+ L + + L+ L
Sbjct: 141 DEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLA 200
Query: 205 SLHLKHLNINNMP 217
L L + +P
Sbjct: 201 RLDLTSNRLQKLP 213
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 140 bits (353), Expect = 3e-33
Identities = 100/353 (28%), Positives = 171/353 (48%), Gaps = 27/353 (7%)
Query: 28 CPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEID 87
C A C C + V C + L A+PEG+ T+ LD+S N + + + F ++P LEE+
Sbjct: 29 CAAPCSCDGDRR-VDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQ 87
Query: 88 LSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDY 147
L+ N ++ + P A + L L+ L L+ N+LK VP GLS L L + N I + +
Sbjct: 88 LAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPED 147
Query: 148 MFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLH 207
F+ L L+ L + DN L + S L +L+ LTL ++++P A ++L SL+ LH
Sbjct: 148 SFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLH 207
Query: 208 LKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFL 267
L + I ++ + F L +L+ L+++Y L + A +L L + ++S +P
Sbjct: 208 LHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALP-SLKELGFHSNSISVIPDG 266
Query: 268 AFKHLVYLTHLNLSYNPISTIEAGMFSDL-----------------------IRLQELHI 304
AF L ++L NP+S + F +L + L+ L +
Sbjct: 267 AFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTL 326
Query: 305 VGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
G ++ +I + Q + LR L++S N + L F+ ALE +S+ N +
Sbjct: 327 TGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQI 377
Score = 110 bits (274), Expect = 5e-24
Identities = 96/324 (29%), Positives = 153/324 (47%), Gaps = 28/324 (8%)
Query: 58 ETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRL 117
E K+L L N+LK+V E L+ + L N I +V +F L LR L L N L
Sbjct: 106 ELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSL 165
Query: 118 KLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLL 177
VP+ + L L L ++ NKI + D+ F +L +L L + +N + +S F GL
Sbjct: 166 TEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLD 225
Query: 178 SLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMP--------------VY---- 219
+LE L L NL P +A+ L SL L +I+ +P +Y
Sbjct: 226 NLETLDLNYNNLGEFP-QAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPL 284
Query: 220 ------AFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLV 273
AF L L L I ++ P N ++L SL++T T +S++P +
Sbjct: 285 SFVGNSAFHNLSDLHSLVIRGASMVQQFP-NLTGTVHLESLTLTGTKISSIPNNLCQEQK 343
Query: 274 YLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLL 333
L L+LSYN I + + F+ L+E+ + Q+ I+ +FQGL LR+L++S+NL+
Sbjct: 344 MLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLI 401
Query: 334 ETLEENVFSSPRALEVLSINNNPL 357
+ F++ + L ++ N L
Sbjct: 402 HEIHSRAFATLGPITNLDVSFNEL 425
Score = 48.9 bits (115), Expect = 1e-05
Identities = 54/220 (24%), Positives = 83/220 (37%), Gaps = 49/220 (22%)
Query: 60 KILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNL--------------- 104
K L N + + F PLL I L DN ++ V AF+NL
Sbjct: 251 KELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQ 310
Query: 105 --------FNLRSLRLKGNRLKLVP----------------------LGVFTGLSNLTKL 134
+L SL L G ++ +P L F G L ++
Sbjct: 311 QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEI 370
Query: 135 DISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPT 194
+ N+I + + FQ L +L+ L++ N + I RAF+ L + L + LT+ PT
Sbjct: 371 SLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPT 430
Query: 195 EALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDY 234
E L+ L L + N A K +L+ L + Y
Sbjct: 431 EGLNGLNQLKLVG----NFKLKEALAAKDFVNLRSLSVPY 466
Score = 48.1 bits (113), Expect = 2e-05
Identities = 38/128 (29%), Positives = 62/128 (48%), Gaps = 8/128 (6%)
Query: 39 KSVSCHRRRLIAIPEGIPIETKIL---DLSKNRLKSVNPEEFISYPLLEEIDLSDNIIAN 95
+S++ ++ +IP + E K+L DLS N ++ + F LEEI L N I
Sbjct: 322 ESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDL--PSFNGCHALEEISLQRNQIYQ 379
Query: 96 VEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNL 155
++ G F L +LR L L N + + F L +T LD+S N+ L + + L+ L
Sbjct: 380 IKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNE---LTSFPTEGLNGL 436
Query: 156 KSLEVGDN 163
L++ N
Sbjct: 437 NQLKLVGN 444
>gi|149773484 leucine rich repeat and fibronectin type III domain
containing 1 [Homo sapiens]
Length = 771
Score = 138 bits (348), Expect = 1e-32
Identities = 106/346 (30%), Positives = 155/346 (44%), Gaps = 31/346 (8%)
Query: 158 LEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMP 217
L + DN + + R F+ + SL LTL + + V A + LR+L +LHL + +
Sbjct: 70 LRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVR 129
Query: 218 VYAFKRLFHLKHLEIDYWPLLDMMPAN-SLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLT 276
+ L +L+HL + + + A + + L ++ NL +P+ A +V L
Sbjct: 130 GDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLN 189
Query: 277 HLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETL 336
L L +N I I G F L +L L + +L + P FLR
Sbjct: 190 TLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGL----FLR------------ 233
Query: 337 EENVFSSPRALEVLSINNNPLACDCRLLWI--LQRQPTLQFGGQQPMCAGPDTIRERSFK 394
+ P +S NPL C+C LLW+ L R+ L+ CA P+ + +R F
Sbjct: 234 SQGTGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDLE------TCATPEHLTDRYFW 287
Query: 395 DFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITT 454
F C+ P I + LV EGQ V L C A GDP+PV+ WV P R +
Sbjct: 288 SIPEEE----FLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGN 343
Query: 455 KSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
S R V GDGTL++ +DSG + CIASNAAG T + V
Sbjct: 344 SS--RTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCV 387
Score = 76.3 bits (186), Expect = 8e-14
Identities = 68/227 (29%), Positives = 103/227 (45%), Gaps = 33/227 (14%)
Query: 11 PFLGLAVVLIFMGSTIG--CPARCECS--AQNKSVSCHRRRLIAIPEGIPIETKILDLSK 66
PFL +L++ G++ G CP RC C A ++ C + L+ +P I L L+
Sbjct: 19 PFL----LLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTD 74
Query: 67 NRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFT 126
N + +V +F + L + LS N I V GAF +L LR+L L NRL V
Sbjct: 75 NFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLR 134
Query: 127 GLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLS-LEQLTLE 185
GL NL+ L +G+N + + AF LS +E L L
Sbjct: 135 GLG------------------------NLRHLILGNNQIRRVESAAFDAFLSTVEDLDLS 170
Query: 186 KCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEI 232
NL A+P EA+ + +L +L L H I+++ F +L L L++
Sbjct: 171 YNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDM 217
Score = 47.8 bits (112), Expect = 3e-05
Identities = 28/93 (30%), Positives = 46/93 (49%)
Query: 251 LTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLR 310
+ L +T+ ++ V F ++ L HL LS N I + AG F+DL L+ LH+ +L
Sbjct: 67 VVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLA 126
Query: 311 TIEPHSFQGLRFLRVLNVSQNLLETLEENVFSS 343
+ +GL LR L + N + +E F +
Sbjct: 127 EVRGDQLRGLGNLRHLILGNNQIRRVESAAFDA 159
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 138 bits (348), Expect = 1e-32
Identities = 160/602 (26%), Positives = 253/602 (42%), Gaps = 109/602 (18%)
Query: 12 FLGLAVVLIFMGSTIG-CPARCECSAQNKSVSCHRRRLIA-----IPEGIPIETKILDLS 65
F+ +L+ + G CPA C C + C RR+L A + +P +T ILD S
Sbjct: 26 FIAQTALLLLPAAGAGLCPAPCSCRIP--LLDCSRRKLPAPSWRALSGLLPPDTAILDFS 83
Query: 66 KNRLKS---------------------------------------------VNPEEFISY 80
NRL + +N + Y
Sbjct: 84 HNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFY 143
Query: 81 PLLEEIDLSDNIIANV-----------------------EPGAFNNLFN-LRSLRLKGNR 116
P LE +DLS NII+ + E G F+NL + L ++L NR
Sbjct: 144 PALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNR 203
Query: 117 LKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGL 176
+ ++P +F L +L L++ N+I I+ FQ L +L+SL++ N + + AF GL
Sbjct: 204 MSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGL 262
Query: 177 LSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWP 236
++E+L LE NLT V L LR L L++ I + A++ L L++ Y
Sbjct: 263 NNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSY-N 321
Query: 237 LLDMMPANSLYGLNLTS-LSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPIS-TIE--AGM 292
L + ++ GL+L L++ + ++ + F+ L L L+L N IS IE +
Sbjct: 322 QLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEA 381
Query: 293 FSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSI 352
F+ L L +L + G Q+++I +F GL L L+++ N + +++EN FS E++ +
Sbjct: 382 FAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELI-L 440
Query: 353 NNNPLACDCRLLWILQRQPTLQF-GGQQPMCAGPDTIRERSFKDFHSTALSFYFTCK--- 408
N + L CDC L W+LQ F CA P+ + +S + F C
Sbjct: 441 NTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKD----FVCDDFL 496
Query: 409 KPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWV----------TPRRRFITTKSNG 458
KP+IR + ++ G V L C+A +S V F+
Sbjct: 497 KPQIRTHP-ETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQA 555
Query: 459 RATVLGDGTLEIRFAQDQDSGMYVCIASNAAG-NDTFTASLTVKGFASDRFLYANRTPMY 517
+ L + D G Y CI +N G N + A LTV S FL +TPM
Sbjct: 556 GEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPS--FL---KTPMD 610
Query: 518 MT 519
+T
Sbjct: 611 LT 612
Score = 84.3 bits (207), Expect = 3e-16
Identities = 123/518 (23%), Positives = 206/518 (39%), Gaps = 80/518 (15%)
Query: 41 VSCHRRRLIAIPEGI---PIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVE 97
V +R R+ IP I P + L+L +NR+K V F L + + N I+ ++
Sbjct: 197 VKLNRNRMSMIPPKIFKLP-HLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLK 255
Query: 98 PGAFNNLFNLRSLRLKGNRLKLVPLGVFTGL------------------------SNLTK 133
GAF L N+ L L+ N L V G GL L++
Sbjct: 256 DGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSE 315
Query: 134 LDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAV- 192
LD+S N++ L + F L L+ L +GDN + +I+ F L +L+ L L ++
Sbjct: 316 LDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAI 375
Query: 193 --PTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLN 250
+EA + L SL L L+ I ++ AF L L+HL+++ N++ +
Sbjct: 376 EDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNN---------NAIMSIQ 426
Query: 251 LTSLSVTNTN---LSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELH---I 304
+ S T+ L+T L HL +L + N F + + H +
Sbjct: 427 ENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNN---------FQHSVNVSCAHPEWL 477
Query: 305 VGAQLRTIEPHSFQGLRFLR--VLNVSQNLLETLEENVFSSPRALEVLSINNNPLAC--- 359
G + ++ F FL+ + + ++ NV + A+ S +++P++
Sbjct: 478 AGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAV---SSSDSPMSTVWR 534
Query: 360 -DCRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTAL----------SFYFTCK 408
D +L+ + + +++ Q +I +F S Y
Sbjct: 535 KDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKA 594
Query: 409 KPKIRE-----KKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVL 463
K + E K L + G +LEC+A+G P P ISW R V+
Sbjct: 595 KLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVM 654
Query: 464 -GDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
D I + +D G+Y C+A N AG + ASLTV
Sbjct: 655 PEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTV 692
Score = 40.4 bits (93), Expect = 0.005
Identities = 24/78 (30%), Positives = 37/78 (47%), Gaps = 2/78 (2%)
Query: 415 KKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQ 474
+ L+ V G+T L+C A G P P ++W + T+ + A + L I A
Sbjct: 700 RPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAA--ANQLLIIVDAG 757
Query: 475 DQDSGMYVCIASNAAGND 492
+D+G Y CI SN G +
Sbjct: 758 LEDAGKYTCIMSNTLGTE 775
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 137 bits (344), Expect = 4e-32
Identities = 103/347 (29%), Positives = 161/347 (46%), Gaps = 32/347 (9%)
Query: 158 LEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMP 217
L + DN + I + F+ + SL LTL + ++ + A + LR+L +LHL + +
Sbjct: 56 LRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKIT 115
Query: 218 VYAFKRLFHLKHLEID--YWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYL 275
F L +L HL ++ L+ + ++ L L ++ NL T+P+ A + +V L
Sbjct: 116 NDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALE--ELDLSYNNLETIPWDAVEKMVSL 173
Query: 276 THLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLET 335
L+L +N I I G FS L ++ L + +L+ + P F R +
Sbjct: 174 HTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPL----FQRA--------QV 221
Query: 336 LEENVFSSPRALEVLSINNNPLACDCRLLWI--LQRQPTLQFGGQQPMCAGPDTIRERSF 393
L + SP LS NPL C+C LLW+ L R+ L+ CA P + R F
Sbjct: 222 LATSGIISPSTF-ALSFGGNPLHCNCELLWLRRLSREDDLE------TCASPPLLTGRYF 274
Query: 394 KDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFIT 453
F C+ P I + + V EGQ L C A GDP+P I W++P + I+
Sbjct: 275 WSIPEEE----FLCEPPLI-TRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLIS 329
Query: 454 TKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
+ R+ V +GTL+I +D+G + CIASN AG T L +
Sbjct: 330 NAT--RSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHI 374
Score = 99.8 bits (247), Expect = 7e-21
Identities = 58/192 (30%), Positives = 101/192 (52%), Gaps = 2/192 (1%)
Query: 28 CPARCECS--AQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEE 85
CP RC C + N + C ++ L+ +P I T L L+ N + ++ ++F + L +
Sbjct: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVD 79
Query: 86 IDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILL 145
+ LS N I+ + P AF +L NLR+L L NRL + +F+GLSNL L ++ N++ ++
Sbjct: 80 LTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLIS 139
Query: 146 DYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLIS 205
F D+ L+ L++ N+L I A ++SL L+L+ + +P SHL +
Sbjct: 140 STAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTR 199
Query: 206 LHLKHLNINNMP 217
L + + +P
Sbjct: 200 LDVTSNKLQKLP 211
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 136 bits (342), Expect = 6e-32
Identities = 103/334 (30%), Positives = 160/334 (47%), Gaps = 4/334 (1%)
Query: 28 CPARCECS----AQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLL 83
CPA C CS A SV C R L +P+G+P T+ L L N L SV P F + L
Sbjct: 79 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 138
Query: 84 EEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVI 143
++L + ++EP A L NL L L+ N+L+ + LG F L L +S N++
Sbjct: 139 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 198
Query: 144 LLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSL 203
L D +F+ L +L L +G N L + AF GL SL +L L L + S L L
Sbjct: 199 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 258
Query: 204 ISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLST 263
L L + + F +L L+ L +D + + P L L L +++ ++
Sbjct: 259 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 318
Query: 264 VPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFL 323
+ F L+ L L LS+N I+++ F DL L+EL + ++R + SF+GL L
Sbjct: 319 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 378
Query: 324 RVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
VL + N L+ ++ F + V++++ N L
Sbjct: 379 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 412
Score = 122 bits (305), Expect = 1e-27
Identities = 102/330 (30%), Positives = 150/330 (45%), Gaps = 28/330 (8%)
Query: 58 ETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRL 117
E + LDLS+N L+++ F+ P L+++ L N+IA V PGAF L LR L L NR+
Sbjct: 257 ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV 316
Query: 118 KLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLL 177
+ F GL L L +S N I L F+DLH L+ L++G N + ++ R+F GL
Sbjct: 317 AGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG 376
Query: 178 SLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPL 237
LE LTL+ L V A L ++ ++L + N+P F+ L L L ++ L
Sbjct: 377 QLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCL 436
Query: 238 LDMMP-----------------------ANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLV 273
+ P SL+GL L L +T+ L+ +P F+ L
Sbjct: 437 GRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLG 496
Query: 274 YLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLL 333
L +L LS N ++ + A L R L + +L + L LR L++ N L
Sbjct: 497 KLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 556
Query: 334 ETLEENVFSSPRALEVLSINNNPLACDCRL 363
T P LE L + NP C C L
Sbjct: 557 RTFT----PQPPGLERLWLEGNPWDCGCPL 582
Score = 82.8 bits (203), Expect = 8e-16
Identities = 71/249 (28%), Positives = 118/249 (47%), Gaps = 13/249 (5%)
Query: 122 LGVFTGLSNLTKLD-----------ISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISH 170
L VF NLT+L + N + + FQ+L +L L + L +
Sbjct: 94 LSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEP 153
Query: 171 RAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHL 230
+A GL +L L LE+ L ++ +H +L SL L + ++ + F+ L L L
Sbjct: 154 QALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDL 213
Query: 231 EIDYWPLLDMMPANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIE 289
+ W L ++P + GL +L L + L+ + F L L L+LS N + I+
Sbjct: 214 NLG-WNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272
Query: 290 AGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEV 349
A +F L RLQ+L++ + + P +F GL+ LR L++S N + L E+ F L V
Sbjct: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 332
Query: 350 LSINNNPLA 358
L +++N +A
Sbjct: 333 LRLSHNAIA 341
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 136 bits (342), Expect = 6e-32
Identities = 103/334 (30%), Positives = 160/334 (47%), Gaps = 4/334 (1%)
Query: 28 CPARCECS----AQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLL 83
CPA C CS A SV C R L +P+G+P T+ L L N L SV P F + L
Sbjct: 41 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100
Query: 84 EEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVI 143
++L + ++EP A L NL L L+ N+L+ + LG F L L +S N++
Sbjct: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 160
Query: 144 LLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSL 203
L D +F+ L +L L +G N L + AF GL SL +L L L + S L L
Sbjct: 161 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 220
Query: 204 ISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLST 263
L L + + F +L L+ L +D + + P L L L +++ ++
Sbjct: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
Query: 264 VPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFL 323
+ F L+ L L LS+N I+++ F DL L+EL + ++R + SF+GL L
Sbjct: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 340
Query: 324 RVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
VL + N L+ ++ F + V++++ N L
Sbjct: 341 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374
Score = 122 bits (305), Expect = 1e-27
Identities = 102/330 (30%), Positives = 150/330 (45%), Gaps = 28/330 (8%)
Query: 58 ETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRL 117
E + LDLS+N L+++ F+ P L+++ L N+IA V PGAF L LR L L NR+
Sbjct: 219 ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV 278
Query: 118 KLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLL 177
+ F GL L L +S N I L F+DLH L+ L++G N + ++ R+F GL
Sbjct: 279 AGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG 338
Query: 178 SLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPL 237
LE LTL+ L V A L ++ ++L + N+P F+ L L L ++ L
Sbjct: 339 QLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCL 398
Query: 238 LDMMP-----------------------ANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLV 273
+ P SL+GL L L +T+ L+ +P F+ L
Sbjct: 399 GRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLG 458
Query: 274 YLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLL 333
L +L LS N ++ + A L R L + +L + L LR L++ N L
Sbjct: 459 KLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 518
Query: 334 ETLEENVFSSPRALEVLSINNNPLACDCRL 363
T P LE L + NP C C L
Sbjct: 519 RTFT----PQPPGLERLWLEGNPWDCGCPL 544
Score = 82.8 bits (203), Expect = 8e-16
Identities = 71/249 (28%), Positives = 118/249 (47%), Gaps = 13/249 (5%)
Query: 122 LGVFTGLSNLTKLD-----------ISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISH 170
L VF NLT+L + N + + FQ+L +L L + L +
Sbjct: 56 LSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEP 115
Query: 171 RAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHL 230
+A GL +L L LE+ L ++ +H +L SL L + ++ + F+ L L L
Sbjct: 116 QALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDL 175
Query: 231 EIDYWPLLDMMPANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIE 289
+ W L ++P + GL +L L + L+ + F L L L+LS N + I+
Sbjct: 176 NLG-WNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
Query: 290 AGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEV 349
A +F L RLQ+L++ + + P +F GL+ LR L++S N + L E+ F L V
Sbjct: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294
Query: 350 LSINNNPLA 358
L +++N +A
Sbjct: 295 LRLSHNAIA 303
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 136 bits (342), Expect = 6e-32
Identities = 117/468 (25%), Positives = 195/468 (41%), Gaps = 87/468 (18%)
Query: 13 LGLAVVLIFMGS-TIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKS 71
L LA+ + G + CP +C CSA SV CH L A+P GIP + LDL +N +
Sbjct: 18 LALALASVLSGPPAVACPTKCTCSAA--SVDCHGLGLRAVPRGIPRNAERLDLDRNNITR 75
Query: 72 VNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNL 131
+ +F L + L DN ++ +E GAF +L L LRL N+L+++P +F L
Sbjct: 76 ITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKL 135
Query: 132 TKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTA 191
T+LD+SEN+I + F+ + ++K+L++ +N + I AF L LE LTL N++
Sbjct: 136 TRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISR 195
Query: 192 VPTEALSHLRSL--ISLHLKHLNIN------------NMPVYAFKRLFHLKHL------E 231
+ + +H+ + + LH HL + V F HL +
Sbjct: 196 ILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVAD 255
Query: 232 IDYWPLLDMMPANSLYGLNLTSLSVTN--TNLSTVPFLAFKHLVY--------LTHLNLS 281
+ + P + N S+S + T + + K L+ + + L
Sbjct: 256 VQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLE 315
Query: 282 YNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRF------------------- 322
N I I AG F+ +L+ + I Q+ I P +FQGL+
Sbjct: 316 QNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLF 375
Query: 323 -----------------------------LRVLNVSQNLLETLEENVFSSPRALEVLSIN 353
L +L++ N L+T+ + +F+ ++++ L +
Sbjct: 376 DGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLA 435
Query: 354 NNPLACDCRLLWI---LQRQPTLQFGGQQPMCAGPDTIRERSFKDFHS 398
NP CDC L W+ LQ P G + C+ P + + S
Sbjct: 436 QNPFVCDCHLKWLADYLQDNPIETSGAR---CSSPRRLANKRISQIKS 480
Score = 129 bits (324), Expect = 8e-30
Identities = 118/419 (28%), Positives = 193/419 (46%), Gaps = 51/419 (12%)
Query: 28 CPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEE-FISYPLLEEI 86
CP +C C + V C ++L+ IP +P L L+ N + + F P L +I
Sbjct: 505 CPEKCRC--EGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKI 562
Query: 87 DLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLD 146
+LS+N I V GAF+ +++ L L GN+L+ V VF GLS L L + N I + +
Sbjct: 563 NLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSN 622
Query: 147 YMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHL------ 200
F L +++ L + DN + I+ AF+ L+SL + NL + P HL
Sbjct: 623 DTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTI-----NLLSNPFNCNCHLAWLGKW 677
Query: 201 ---RSLIS--------LHLKHLNINNMPVYAF------KRLFHLKHLEIDYWPLLDMMPA 243
R ++S LK + I ++ + F + L + ++ +
Sbjct: 678 LRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVR 737
Query: 244 NSLYGL---------NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFS 294
S GL ++T L + +L+ VP L +LT ++LS N IS + FS
Sbjct: 738 CSNKGLRALPRGMPKDVTELYLEGNHLTAVP-RELSALRHLTLIDLSNNSISMLTNYTFS 796
Query: 295 DLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINN 354
++ L L + +LR I H+F GLR LRVL + N + ++ E F+ +L L++
Sbjct: 797 NMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGT 856
Query: 355 NPLACDCRLLWILQRQPTLQFGGQQP---MCAGPDTIRERSFKDFHSTALSFYFTCKKP 410
NPL CDC L W+ + ++ G ++P C+ P+ + +R T + F CK P
Sbjct: 857 NPLHCDCSLRWLSE---WVKAGYKEPGIARCSSPEPMADRLL----LTTPTHRFQCKGP 908
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 135 bits (340), Expect = 1e-31
Identities = 102/357 (28%), Positives = 161/357 (45%), Gaps = 29/357 (8%)
Query: 27 GCPARCECSAQNKS---VSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLL 83
GCP C C + V C L +P + + T LDLS N + + P S L
Sbjct: 33 GCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFL 92
Query: 84 EEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVI 143
EE+ L+ N + + GAF L++L+ L L+ N+L+ VP L +L L + N I
Sbjct: 93 EELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISY 152
Query: 144 LLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSL 203
+ F LH+L+ L + DN L I +AF L +L+ +TL + +P A +L SL
Sbjct: 153 VPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSL 212
Query: 204 ISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLST 263
+ LHL + I+++ F L L+ L+++Y LD P NL L + N+ +
Sbjct: 213 VVLHLHNNRIHSLGKKCFDGLHSLETLDLNY-NNLDEFPTAIRTLSNLKELGFHSNNIRS 271
Query: 264 VPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDL-----------------------IRLQ 300
+P AF L ++ NPI + F L L+
Sbjct: 272 IPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLE 331
Query: 301 ELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
L + GAQ+ ++ L L+VL++S NLLE L FS + L+ + + +N +
Sbjct: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEI 386
Score = 60.8 bits (146), Expect = 3e-09
Identities = 55/192 (28%), Positives = 78/192 (40%), Gaps = 25/192 (13%)
Query: 60 KILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNL--------------- 104
K L N ++S+ + F+ P L I DN I V AF +L
Sbjct: 260 KELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQIT 319
Query: 105 --------FNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLK 156
NL SL L G ++ +P V L NL LD+S N + L F L+
Sbjct: 320 EFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQ 377
Query: 157 SLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNM 216
+++ N++ I F LLSL L L + + A S L SLI L L +++
Sbjct: 378 KIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSF 437
Query: 217 PVYAFKRLFHLK 228
P+ L HLK
Sbjct: 438 PITGLHGLTHLK 449
Score = 54.3 bits (129), Expect = 3e-07
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 7/130 (5%)
Query: 60 KILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKL 119
++LDLS N L+ + F L++IDL N I ++ F L +LRSL L N++ +
Sbjct: 355 QVLDLSYNLLEDL--PSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAI 412
Query: 120 VPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLV--YISHRAFSGLL 177
+ F+ L +L KLD+S N +L + LH L L++ N + IS F L
Sbjct: 413 IHPNAFSTLPSLIKLDLSSN---LLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELK 469
Query: 178 SLEQLTLEKC 187
+E +C
Sbjct: 470 VIEMPYAYQC 479
Score = 48.9 bits (115), Expect = 1e-05
Identities = 49/152 (32%), Positives = 75/152 (49%), Gaps = 15/152 (9%)
Query: 83 LEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIV 142
LE + L+ I+++ N L NL+ L L N L+ +P F+ L K+D+ N+I
Sbjct: 330 LESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIY 387
Query: 143 ILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVP---TEALSH 199
+ FQ L +L+SL + N + I AFS L SL +L L L++ P L+H
Sbjct: 388 EIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTH 447
Query: 200 LR--------SLISL-HLKHLNINNMPVYAFK 222
L+ SLIS + L + MP YA++
Sbjct: 448 LKLTGNHALQSLISSENFPELKVIEMP-YAYQ 478
Score = 41.2 bits (95), Expect = 0.003
Identities = 26/86 (30%), Positives = 44/86 (51%)
Query: 273 VYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNL 332
V+ ++L+LS N IS + L L+EL + G L I +F GL L+VL + N
Sbjct: 66 VFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQ 125
Query: 333 LETLEENVFSSPRALEVLSINNNPLA 358
L + + R+L+ L ++ N ++
Sbjct: 126 LRHVPTEALQNLRSLQSLRLDANHIS 151
Score = 33.1 bits (74), Expect = 0.76
Identities = 17/59 (28%), Positives = 33/59 (55%), Gaps = 3/59 (5%)
Query: 57 IETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGN 115
+ + L+L+ N++ ++P F + P L ++DLS N++++ L L L+L GN
Sbjct: 398 LSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSF---PITGLHGLTHLKLTGN 453
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 134 bits (337), Expect = 2e-31
Identities = 130/469 (27%), Positives = 228/469 (48%), Gaps = 37/469 (7%)
Query: 57 IETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLF-NLRSLRLKGN 115
+ ++LDLS N + V F P ++E++L+ N I +E GAF+ L +L +LRL N
Sbjct: 139 LSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKN 198
Query: 116 RLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSG 175
R+ +P+ F L LT+LD++ N+I ++ FQ L++L+ L++ N++ ++ AF G
Sbjct: 199 RITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWG 257
Query: 176 LLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNM--PVYAFKRLFHLKHLEID 233
L + L LE +L V + +L L +L LHL + +I + ++F + H L +
Sbjct: 258 LSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFN 317
Query: 234 YWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPIS-TIE--A 290
LD L L++ LS + ++S + AFK L L L+L +N IS TIE +
Sbjct: 318 NLTRLDEESLAELSSLSVLRLS--HNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTS 375
Query: 291 GMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVL 350
G FS L L +L + G +++++ +F GL L LN+ N + +++ + F + L+ L
Sbjct: 376 GAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKEL 435
Query: 351 SINNNPLACDCRLLWILQRQPTLQFGGQ-----QPMCAGPDTIRERSFKDFHSTALSFYF 405
I+++ CDC+L W+ P G CA P++++ +S + F
Sbjct: 436 HISSDSFLCDCQLKWL----PPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPES----F 487
Query: 406 TCK---KPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATV 462
C KP+I + + + G+ ++ CSA +++ + + T ++ V
Sbjct: 488 VCDDFLKPQIITQP-ETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFV 546
Query: 463 ---LGDG-------TLEIRFAQDQDSGMYVCIASNAAGND-TFTASLTV 500
DG L +R G Y C+ +N G+ + A LTV
Sbjct: 547 HVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTV 595
Score = 102 bits (254), Expect = 1e-21
Identities = 78/255 (30%), Positives = 127/255 (49%), Gaps = 4/255 (1%)
Query: 53 EGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRL 112
+G+ L LSKNR+ + P P L ++DL+ N I +E F L +L L+L
Sbjct: 184 DGLSRSLLTLRLSKNRITQL-PVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKL 242
Query: 113 KGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRA 172
+ N + + G F GLS + L + N +V + L L L + +N + I +
Sbjct: 243 QRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKG 302
Query: 173 FSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEI 232
+S L +L L NLT + E+L+ L SL L L H +I+++ AFK L L+ L++
Sbjct: 303 WSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDL 362
Query: 233 DYWPLLDMM--PANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIE 289
D+ + + + + GL +L+ L++ + +V AF L L HLNL N I +++
Sbjct: 363 DHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQ 422
Query: 290 AGMFSDLIRLQELHI 304
F + L+ELHI
Sbjct: 423 FDAFVKMKNLKELHI 437
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/84 (29%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 417 LQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQ 476
L+ +V G+TV L+C A G+P P I+W R T+ + + L ++ +
Sbjct: 699 LEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTP--DNQLLVVQNVVAE 756
Query: 477 DSGMYVCIASNAAGNDTFTASLTV 500
D+G Y C SN G + + L+V
Sbjct: 757 DAGRYTCEMSNTLGTERAHSQLSV 780
Score = 42.4 bits (98), Expect = 0.001
Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 5/75 (6%)
Query: 429 QLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQD---QDSGMYVCIA 485
+LEC+A G P P I+W R V+ D ++ F D D+G+Y C A
Sbjct: 617 RLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDD--DVFFITDVKIDDAGVYSCTA 674
Query: 486 SNAAGNDTFTASLTV 500
N+AG+ + A+LTV
Sbjct: 675 QNSAGSISANATLTV 689
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 132 bits (331), Expect = 1e-30
Identities = 96/332 (28%), Positives = 160/332 (48%), Gaps = 4/332 (1%)
Query: 28 CPARCECSAQN--KSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEE 85
CPA C C S C L A+P + T LDLS N L + P F LEE
Sbjct: 35 CPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEE 94
Query: 86 IDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILL 145
+ LS N ++++ AF+ L++L+ L L+ N+L +P L +L L + N I ++
Sbjct: 95 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVP 154
Query: 146 DYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLIS 205
+ F+ L +L+ L + DN L I RA + L +L+ +TL ++ +P A +L SL+
Sbjct: 155 ERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVV 214
Query: 206 LHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVP 265
LHL + I ++ ++F+ L +L+ L+++Y L + A G L L N N+ +P
Sbjct: 215 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLG-RLQELGFHNNNIKAIP 273
Query: 266 FLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRV 325
AF L ++ NPI + F L +L L + GA + E +G L +
Sbjct: 274 EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGA-MDIQEFPDLKGTTSLEI 332
Query: 326 LNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
L +++ + L + L VL +++N +
Sbjct: 333 LTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 364
Score = 59.3 bits (142), Expect = 1e-08
Identities = 55/193 (28%), Positives = 80/193 (41%), Gaps = 31/193 (16%)
Query: 62 LDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNR----- 116
L N +K++ + F+ PLL+ I DN I V AF L L +L L G
Sbjct: 262 LGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEF 321
Query: 117 ------------------LKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSL 158
++L+P G+ L L L++S N+I L LH + L
Sbjct: 322 PDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL-----PSLHRCQKL 376
Query: 159 E---VGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINN 215
E + N + I FS L SL+ L L + ++ EA S L SL+ L L +
Sbjct: 377 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTT 436
Query: 216 MPVYAFKRLFHLK 228
+P+ L HLK
Sbjct: 437 LPLAGLGGLMHLK 449
Score = 44.3 bits (103), Expect = 3e-04
Identities = 33/121 (27%), Positives = 58/121 (47%), Gaps = 2/121 (1%)
Query: 60 KILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKL 119
+IL L++ ++ + P L ++LS N I + + + L + L+ NR+
Sbjct: 331 EILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWE 388
Query: 120 VPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSL 179
+ F+ LS+L LD+S N I + F LH+L L++ DN L + GL+ L
Sbjct: 389 IGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHL 448
Query: 180 E 180
+
Sbjct: 449 K 449
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,126,419
Number of Sequences: 37866
Number of extensions: 975101
Number of successful extensions: 7254
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 375
Number of HSP's successfully gapped in prelim test: 170
Number of HSP's that attempted gapping in prelim test: 2372
Number of HSP's gapped (non-prelim): 2519
length of query: 606
length of database: 18,247,518
effective HSP length: 108
effective length of query: 498
effective length of database: 14,157,990
effective search space: 7050679020
effective search space used: 7050679020
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.