Guide to the Human Genome
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Search of human proteins with 22748721

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22748721 FERM domain containing 6 [Homo sapiens]
         (614 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109715866 FERM domain containing 6 [Homo sapiens]                 1248   0.0  
gi|22748721 FERM domain containing 6 [Homo sapiens]                  1248   0.0  
gi|170932510 FERM domain containing 1 isoform 1 [Homo sapiens]        379   e-105
gi|170932512 FERM domain containing 1 isoform 2 [Homo sapiens]        365   e-101
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...   150   4e-36
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...   150   4e-36
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...   150   4e-36
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...   147   2e-35
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa...   125   1e-28
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa...   125   1e-28
gi|4505257 moesin [Homo sapiens]                                       91   2e-18
gi|161702986 ezrin [Homo sapiens]                                      91   3e-18
gi|21614499 ezrin [Homo sapiens]                                       91   3e-18
gi|4506467 radixin [Homo sapiens]                                      91   4e-18
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]                   83   6e-16
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]                   83   6e-16
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]                   83   6e-16
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]                    83   6e-16
gi|150010540 FERM domain containing 4B [Homo sapiens]                  80   4e-15
gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens]                   77   5e-14
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [...    77   6e-14
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]          77   6e-14
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho...    75   2e-13
gi|116063562 FERM domain containing 4A [Homo sapiens]                  75   2e-13
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]         75   2e-13
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i...    72   2e-12
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i...    72   2e-12
gi|117500790 FERM domain containing 3 [Homo sapiens]                   69   1e-11
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ...    68   2e-11
gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens]                   66   1e-10

>gi|109715866 FERM domain containing 6 [Homo sapiens]
          Length = 614

 Score = 1248 bits (3230), Expect = 0.0
 Identities = 614/614 (100%), Positives = 614/614 (100%)

Query: 1   MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS 60
           MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS
Sbjct: 1   MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS 60

Query: 61  VIQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAA 120
           VIQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAA
Sbjct: 61  VIQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAA 120

Query: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180
           RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV
Sbjct: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180

Query: 181 SKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLT 240
           SKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLT
Sbjct: 181 SKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLT 240

Query: 241 LGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPM 300
           LGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPM
Sbjct: 241 LGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPM 300

Query: 301 RSRHLLQLLSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRA 360
           RSRHLLQLLSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRA
Sbjct: 301 RSRHLLQLLSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRA 360

Query: 361 SGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMT 420
           SGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMT
Sbjct: 361 SGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMT 420

Query: 421 SHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDML 480
           SHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDML
Sbjct: 421 SHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDML 480

Query: 481 MSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDI 540
           MSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDI
Sbjct: 481 MSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDI 540

Query: 541 RLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYF 600
           RLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYF
Sbjct: 541 RLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYF 600

Query: 601 SLDLTHDEVPEFVV 614
           SLDLTHDEVPEFVV
Sbjct: 601 SLDLTHDEVPEFVV 614


>gi|22748721 FERM domain containing 6 [Homo sapiens]
          Length = 614

 Score = 1248 bits (3230), Expect = 0.0
 Identities = 614/614 (100%), Positives = 614/614 (100%)

Query: 1   MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS 60
           MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS
Sbjct: 1   MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS 60

Query: 61  VIQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAA 120
           VIQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAA
Sbjct: 61  VIQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAA 120

Query: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180
           RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV
Sbjct: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180

Query: 181 SKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLT 240
           SKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLT
Sbjct: 181 SKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLT 240

Query: 241 LGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPM 300
           LGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPM
Sbjct: 241 LGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPM 300

Query: 301 RSRHLLQLLSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRA 360
           RSRHLLQLLSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRA
Sbjct: 301 RSRHLLQLLSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRA 360

Query: 361 SGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMT 420
           SGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMT
Sbjct: 361 SGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMT 420

Query: 421 SHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDML 480
           SHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDML
Sbjct: 421 SHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDML 480

Query: 481 MSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDI 540
           MSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDI
Sbjct: 481 MSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDI 540

Query: 541 RLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYF 600
           RLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYF
Sbjct: 541 RLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYF 600

Query: 601 SLDLTHDEVPEFVV 614
           SLDLTHDEVPEFVV
Sbjct: 601 SLDLTHDEVPEFVV 614


>gi|170932510 FERM domain containing 1 isoform 1 [Homo sapiens]
          Length = 549

 Score =  379 bits (973), Expect = e-105
 Identities = 232/602 (38%), Positives = 331/602 (54%), Gaps = 105/602 (17%)

Query: 14  DRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELS 73
           + R V + LP+ E L + + VK    +L  QVC++  ++D   FGL V++NNE+++M+L 
Sbjct: 52  EHRDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLE 111

Query: 74  QKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVL 133
           QKL KY  K+WKKE ++G ++   P +   RVQ+YVENGR+ISD  AR+ YY HL+++VL
Sbjct: 112 QKLSKYFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVL 171

Query: 134 HSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIP 193
            SQC  REEAYFLLAA ALQADLG  + + H G+YFEP +YFP W+++KRG DYIL+H+P
Sbjct: 172 RSQCAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMP 231

Query: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
            +H+++  L+  EA L +I+EA RL+DV VH++RL+KDK+E   ++ LGL +RG+ I+Q 
Sbjct: 232 TLHRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ- 290

Query: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSH 313
                                 GKK EI  DGLP+A+KL+YYTGC  RSRHLL LL  SH
Sbjct: 291 ----------------------GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASH 328

Query: 314 RLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRASGSSAGSMKHKRL 373
           +L++ ++P L+ +R+ EE EEK+ YRESYISD L+LD+        AS S  GS    + 
Sbjct: 329 QLHLRVRPTLQQLRQREEAEEKQHYRESYISDELELDL--------ASRSFPGSGVSSQH 380

Query: 374 SRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMTSHGSSHTSGVESG 433
             H  + HS+                                     SHGSS+TSG+++ 
Sbjct: 381 CPHCLSRHSAD------------------------------------SHGSSYTSGIKAN 404

Query: 434 GKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDMLMSRKLNGHSGLIV 493
              R       +  EM VD P ++  ++E+    SP             R    H     
Sbjct: 405 SWLR-------ESREMSVDVPLEVHGLHEKEPSSSP-------------RTSRSHPS--T 442

Query: 494 KEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGL 553
           +    +T     T V+ RGQS +++ Q        S ++HS  LDD++L+Q     +A  
Sbjct: 443 RGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQHSHGLDDMQLHQ-----LALH 497

Query: 554 CQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYFSLDLTHDEVP-EF 612
              T+ S+TF          L C   LA  C   +   P KR+S   +LDL  +  P EF
Sbjct: 498 PAPTSLSHTF-------HRALDCR--LAGPC-ETRATLPSKRSSNCLALDLFGEAPPQEF 547

Query: 613 VV 614
           VV
Sbjct: 548 VV 549


>gi|170932512 FERM domain containing 1 isoform 2 [Homo sapiens]
          Length = 481

 Score =  365 bits (938), Expect = e-101
 Identities = 226/583 (38%), Positives = 321/583 (55%), Gaps = 105/583 (18%)

Query: 33  NVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELSQKLYKYCPKEWKKEASKGI 92
           +VK    +L  QVC++  ++D   FGL V++NNE+++M+L QKL KY  K+WKKE ++G 
Sbjct: 3   DVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGN 62

Query: 93  DQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCVLREEAYFLLAAFAL 152
           ++   P +   RVQ+YVENGR+ISD  AR+ YY HL+++VL SQC  REEAYFLLAA AL
Sbjct: 63  EKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 122

Query: 153 QADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIPNMHKDQFALTASEAHLKYI 212
           QADLG  + + H G+YFEP +YFP W+++KRG DYIL+H+P +H+++  L+  EA L +I
Sbjct: 123 QADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFI 182

Query: 213 KEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKL 272
           +EA RL+DV VH++RL+KDK+E   ++ LGL +RG+ I+Q                    
Sbjct: 183 QEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ-------------------- 222

Query: 273 VFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYMNLQPVLRHIRKLEEN 332
              GKK EI  DGLP+A+KL+YYTGC  RSRHLL LL  SH+L++ ++P L+ +R+ EE 
Sbjct: 223 ---GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEA 279

Query: 333 EEKKQYRESYISDNLDLDMDQLEKRSRASGSSAGSMKHKRLSRHSTASHSSSHTSGIEAD 392
           EEK+ YRESYISD L+LD+        AS S  GS    +   H  + HS+         
Sbjct: 280 EEKQHYRESYISDELELDL--------ASRSFPGSGVSSQHCPHCLSRHSAD-------- 323

Query: 393 TKPRDTGPEDSYSSSAIHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDLQDDEIEMLVD 452
                                       SHGSS+TSG+++    R       +  EM VD
Sbjct: 324 ----------------------------SHGSSYTSGIKANSWLR-------ESREMSVD 348

Query: 453 DPRDLEQMNEESLEVSPDMCIYITEDMLMSRKLNGHSGLIVKEIGSSTSSSSETVVKLRG 512
            P ++  ++E+    SP             R    H     +    +T     T V+ RG
Sbjct: 349 VPLEVHGLHEKEPSSSP-------------RTSRSHPS--TRGDSQATRQEPCTQVRTRG 393

Query: 513 QSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHELDEE 572
           QS +++ Q        S ++HS  LDD++L+Q     +A     T+ S+TF         
Sbjct: 394 QSAEAVHQIQEMTAGVSEEQHSHGLDDMQLHQ-----LALHPAPTSLSHTF-------HR 441

Query: 573 GLYCNSCLAQQCINIQDAFPVKRTSKYFSLDLTHDEVP-EFVV 614
            L C   LA  C   +   P KR+S   +LDL  +  P EFVV
Sbjct: 442 ALDCR--LAGPC-ETRATLPSKRSSNCLALDLFGEAPPQEFVV 481


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
           isoform 4 [Homo sapiens]
          Length = 2490

 Score =  150 bits (378), Expect = 4e-36
 Identities = 100/363 (27%), Positives = 180/363 (49%), Gaps = 18/363 (4%)

Query: 14  DRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELS 73
           +RR V I L N + L +  + K +C  +   V   + L + HLF L+ +++NE+ +++  
Sbjct: 570 NRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPD 629

Query: 74  QKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVL 133
            KL K  P+ WK+E  K   +      + FR+++++++  LI      + YY  LRK +L
Sbjct: 630 LKLTKVAPEGWKEEPKKKT-KATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDIL 688

Query: 134 HSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIP 193
             +    +E   LLA+ ALQA+ G+++   H   YF  E Y P+ V+ K    YI + +P
Sbjct: 689 EERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELP 748

Query: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
            +H      +  E  L+++K   RL +  VH++R++ +K+  +  + LG+  +G+ +F+ 
Sbjct: 749 KLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKS-QTGILLGVCSKGVLVFEV 807

Query: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEI--LPDGLPSARKLIYYTGCPMRSRHLLQLLSN 311
            +  + L+  FPW    K+ F  KK  +    DG+    K  + T      ++LL L S 
Sbjct: 808 HNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGI----KHGFQTDNSKICQYLLHLCSY 863

Query: 312 SHRLYMNLQPVLRHIRKLEENEEKKQY-RESYISDNLDLDMDQLEKRSRA--SGSSAGSM 368
            H+  + +       R  + N++ +   R S+ S NL  +  +     RA  +GS A S 
Sbjct: 864 QHKFQLQM-------RARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASST 916

Query: 369 KHK 371
            +K
Sbjct: 917 LNK 919


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
           isoform 1 [Homo sapiens]
          Length = 2485

 Score =  150 bits (378), Expect = 4e-36
 Identities = 100/363 (27%), Positives = 180/363 (49%), Gaps = 18/363 (4%)

Query: 14  DRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELS 73
           +RR V I L N + L +  + K +C  +   V   + L + HLF L+ +++NE+ +++  
Sbjct: 570 NRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPD 629

Query: 74  QKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVL 133
            KL K  P+ WK+E  K   +      + FR+++++++  LI      + YY  LRK +L
Sbjct: 630 LKLTKVAPEGWKEEPKKKT-KATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDIL 688

Query: 134 HSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIP 193
             +    +E   LLA+ ALQA+ G+++   H   YF  E Y P+ V+ K    YI + +P
Sbjct: 689 EERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELP 748

Query: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
            +H      +  E  L+++K   RL +  VH++R++ +K+  +  + LG+  +G+ +F+ 
Sbjct: 749 KLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKS-QTGILLGVCSKGVLVFEV 807

Query: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEI--LPDGLPSARKLIYYTGCPMRSRHLLQLLSN 311
            +  + L+  FPW    K+ F  KK  +    DG+    K  + T      ++LL L S 
Sbjct: 808 HNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGI----KHGFQTDNSKICQYLLHLCSY 863

Query: 312 SHRLYMNLQPVLRHIRKLEENEEKKQY-RESYISDNLDLDMDQLEKRSRA--SGSSAGSM 368
            H+  + +       R  + N++ +   R S+ S NL  +  +     RA  +GS A S 
Sbjct: 864 QHKFQLQM-------RARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASST 916

Query: 369 KHK 371
            +K
Sbjct: 917 LNK 919


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13
           isoform 2 [Homo sapiens]
          Length = 2466

 Score =  150 bits (378), Expect = 4e-36
 Identities = 100/363 (27%), Positives = 180/363 (49%), Gaps = 18/363 (4%)

Query: 14  DRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELS 73
           +RR V I L N + L +  + K +C  +   V   + L + HLF L+ +++NE+ +++  
Sbjct: 570 NRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPD 629

Query: 74  QKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVL 133
            KL K  P+ WK+E  K   +      + FR+++++++  LI      + YY  LRK +L
Sbjct: 630 LKLTKVAPEGWKEEPKKKT-KATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDIL 688

Query: 134 HSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIP 193
             +    +E   LLA+ ALQA+ G+++   H   YF  E Y P+ V+ K    YI + +P
Sbjct: 689 EERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELP 748

Query: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
            +H      +  E  L+++K   RL +  VH++R++ +K+  +  + LG+  +G+ +F+ 
Sbjct: 749 KLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKS-QTGILLGVCSKGVLVFEV 807

Query: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEI--LPDGLPSARKLIYYTGCPMRSRHLLQLLSN 311
            +  + L+  FPW    K+ F  KK  +    DG+    K  + T      ++LL L S 
Sbjct: 808 HNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGI----KHGFQTDNSKICQYLLHLCSY 863

Query: 312 SHRLYMNLQPVLRHIRKLEENEEKKQY-RESYISDNLDLDMDQLEKRSRA--SGSSAGSM 368
            H+  + +       R  + N++ +   R S+ S NL  +  +     RA  +GS A S 
Sbjct: 864 QHKFQLQM-------RARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASST 916

Query: 369 KHK 371
            +K
Sbjct: 917 LNK 919


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
           isoform 3 [Homo sapiens]
          Length = 2294

 Score =  147 bits (372), Expect = 2e-35
 Identities = 86/309 (27%), Positives = 158/309 (51%), Gaps = 8/309 (2%)

Query: 14  DRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELS 73
           +RR V I L N + L +  + K +C  +   V   + L + HLF L+ +++NE+ +++  
Sbjct: 570 NRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPD 629

Query: 74  QKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVL 133
            KL K  P+ WK+E  K   +      + FR+++++++  LI      + YY  LRK +L
Sbjct: 630 LKLTKVAPEGWKEEPKKKT-KATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDIL 688

Query: 134 HSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIP 193
             +    +E   LLA+ ALQA+ G+++   H   YF  E Y P+ V+ K    YI + +P
Sbjct: 689 EERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELP 748

Query: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
            +H      +  E  L+++K   RL +  VH++R++ +K+  +  + LG+  +G+ +F+ 
Sbjct: 749 KLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKS-QTGILLGVCSKGVLVFEV 807

Query: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEI--LPDGLPSARKLIYYTGCPMRSRHLLQLLSN 311
            +  + L+  FPW    K+ F  KK  +    DG+    K  + T      ++LL L S 
Sbjct: 808 HNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGI----KHGFQTDNSKICQYLLHLCSY 863

Query: 312 SHRLYMNLQ 320
            H+  + ++
Sbjct: 864 QHKFQLQMR 872


>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
           sapiens]
          Length = 1287

 Score =  125 bits (313), Expect = 1e-28
 Identities = 73/300 (24%), Positives = 145/300 (48%), Gaps = 8/300 (2%)

Query: 16  RSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELSQK 75
           R +C+ L N + L +  +V+     +   V     L++   FGL+ +++ E  +++   +
Sbjct: 320 RDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETR 379

Query: 76  LYKYCPKEWKKEASK-GIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLH 134
           L K  P+ W+++  K  ++ F     +  R++++V +  L+     R+ +Y  LRK +L 
Sbjct: 380 LCKIAPEGWREQPQKTSMNTF----TLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILE 435

Query: 135 SQCVLREEAYFLLAAFALQADLGNFKRNKHYGK-YFEPEAYFPSWVVSKRGKDYILKHIP 193
            +    EE    L   ALQA+ GN+ + +   K YF  E Y P+ ++ +     +   + 
Sbjct: 436 ERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVS 495

Query: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
            MH+   AL   +A LK+++   +L +  V  ++++ +KR  E  + LG+  +G+ +++ 
Sbjct: 496 EMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEV 555

Query: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSH 313
            +  +  +  F W   GK+    KKF I      + +K  + T     S++LL L S  H
Sbjct: 556 KNNSRIAMLRFQWRETGKISTYQKKFTITSS--VTGKKHTFVTDSAKTSKYLLDLCSAQH 613


>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
           sapiens]
          Length = 1309

 Score =  125 bits (313), Expect = 1e-28
 Identities = 73/300 (24%), Positives = 145/300 (48%), Gaps = 8/300 (2%)

Query: 16  RSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELSQK 75
           R +C+ L N + L +  +V+     +   V     L++   FGL+ +++ E  +++   +
Sbjct: 342 RDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETR 401

Query: 76  LYKYCPKEWKKEASK-GIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLH 134
           L K  P+ W+++  K  ++ F     +  R++++V +  L+     R+ +Y  LRK +L 
Sbjct: 402 LCKIAPEGWREQPQKTSMNTF----TLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILE 457

Query: 135 SQCVLREEAYFLLAAFALQADLGNFKRNKHYGK-YFEPEAYFPSWVVSKRGKDYILKHIP 193
            +    EE    L   ALQA+ GN+ + +   K YF  E Y P+ ++ +     +   + 
Sbjct: 458 ERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVS 517

Query: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
            MH+   AL   +A LK+++   +L +  V  ++++ +KR  E  + LG+  +G+ +++ 
Sbjct: 518 EMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEV 577

Query: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSH 313
            +  +  +  F W   GK+    KKF I      + +K  + T     S++LL L S  H
Sbjct: 578 KNNSRIAMLRFQWRETGKISTYQKKFTITSS--VTGKKHTFVTDSAKTSKYLLDLCSAQH 635


>gi|4505257 moesin [Homo sapiens]
          Length = 577

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 86/340 (25%), Positives = 152/340 (44%), Gaps = 27/340 (7%)

Query: 25  DESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEH-VYMELSQKLYKYCPKE 83
           D  L   I       QL  QV   + L++   FGL          +++L++K+     ++
Sbjct: 13  DAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKV---TAQD 69

Query: 84  WKKEASKGIDQFGPPMIIHFRVQYYVEN--GRLISDRAARYYYYWHLRKQVLHSQCVLRE 141
            +KE+         P++  FR ++Y E+    LI D   R ++   +++ +L+       
Sbjct: 70  VRKES---------PLLFKFRAKFYPEDVSEELIQDITQRLFFL-QVKEGILNDDIYCPP 119

Query: 142 EAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVS--KRGKDYILKHIPNMHKDQ 199
           E   LLA++A+Q+  G+F +  H   Y   +   P  V+   K  KD   + I   H++ 
Sbjct: 120 ETAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEH 179

Query: 200 FALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQ 259
             +   +A L+Y+K A  L+   V+Y+ + K+K+  E  L LG+   G+ I++  D    
Sbjct: 180 RGMLREDAVLEYLKIAQDLEMYGVNYFSI-KNKKGSE--LWLGVDALGLNIYEQNDRLTP 236

Query: 260 LLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYMNL 319
            +  FPW+ +  + F  KKF I P     A   ++Y      ++ +L L   +H LYM  
Sbjct: 237 KI-GFPWSEIRNISFNDKKFVIKPID-KKAPDFVFYAPRLRINKRILALCMGNHELYMR- 293

Query: 320 QPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSR 359
               R    +E  + K Q RE      ++  M + EK+ R
Sbjct: 294 ---RRKPDTIEVQQMKAQAREEKHQKQMERAMLENEKKKR 330


>gi|161702986 ezrin [Homo sapiens]
          Length = 586

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 84/340 (24%), Positives = 145/340 (42%), Gaps = 27/340 (7%)

Query: 25  DESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEH-VYMELSQKLYKYCPKE 83
           D  L   I       QL  QV   + L++   FGL  + N     +++L +K+     +E
Sbjct: 13  DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKV---SAQE 69

Query: 84  WKKEASKGIDQFGPPMIIHFRVQYYVEN--GRLISDRAARYYYYWHLRKQVLHSQCVLRE 141
            +KE          P+   FR ++Y E+    LI D   + ++   +++ +L  +     
Sbjct: 70  VRKEN---------PLQFKFRAKFYPEDVAEELIQDITQKLFFL-QVKEGILSDEIYCPP 119

Query: 142 EAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVS--KRGKDYILKHIPNMHKDQ 199
           E   LL ++A+QA  G++ +  H   Y   E   P  V+   K  +D     I   H + 
Sbjct: 120 ETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEH 179

Query: 200 FALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQ 259
             +    A L+Y+K A  L+   ++Y+ +   K +    L LG+   G+ I++  D++  
Sbjct: 180 RGMLKDNAMLEYLKIAQDLEMYGINYFEI---KNKKGTDLWLGVDALGLNIYEK-DDKLT 235

Query: 260 LLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYMNL 319
               FPW+ +  + F  KKF I P     A   ++Y      ++ +LQL   +H LYM  
Sbjct: 236 PKIGFPWSEIRNISFNDKKFVIKPID-KKAPDFVFYAPRLRINKRILQLCMGNHELYMR- 293

Query: 320 QPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSR 359
               R    +E  + K Q RE      L+    + EK+ R
Sbjct: 294 ---RRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRR 330


>gi|21614499 ezrin [Homo sapiens]
          Length = 586

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 84/340 (24%), Positives = 145/340 (42%), Gaps = 27/340 (7%)

Query: 25  DESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEH-VYMELSQKLYKYCPKE 83
           D  L   I       QL  QV   + L++   FGL  + N     +++L +K+     +E
Sbjct: 13  DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKV---SAQE 69

Query: 84  WKKEASKGIDQFGPPMIIHFRVQYYVEN--GRLISDRAARYYYYWHLRKQVLHSQCVLRE 141
            +KE          P+   FR ++Y E+    LI D   + ++   +++ +L  +     
Sbjct: 70  VRKEN---------PLQFKFRAKFYPEDVAEELIQDITQKLFFL-QVKEGILSDEIYCPP 119

Query: 142 EAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVS--KRGKDYILKHIPNMHKDQ 199
           E   LL ++A+QA  G++ +  H   Y   E   P  V+   K  +D     I   H + 
Sbjct: 120 ETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEH 179

Query: 200 FALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQ 259
             +    A L+Y+K A  L+   ++Y+ +   K +    L LG+   G+ I++  D++  
Sbjct: 180 RGMLKDNAMLEYLKIAQDLEMYGINYFEI---KNKKGTDLWLGVDALGLNIYEK-DDKLT 235

Query: 260 LLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYMNL 319
               FPW+ +  + F  KKF I P     A   ++Y      ++ +LQL   +H LYM  
Sbjct: 236 PKIGFPWSEIRNISFNDKKFVIKPID-KKAPDFVFYAPRLRINKRILQLCMGNHELYMR- 293

Query: 320 QPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSR 359
               R    +E  + K Q RE      L+    + EK+ R
Sbjct: 294 ---RRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRR 330


>gi|4506467 radixin [Homo sapiens]
          Length = 583

 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 83/340 (24%), Positives = 157/340 (46%), Gaps = 27/340 (7%)

Query: 25  DESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEH-VYMELSQKLYKYCPKE 83
           D  L   I       QL  QV   + L++   FGL  + +  +  +++L++K+ +   ++
Sbjct: 13  DAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQ---QD 69

Query: 84  WKKEASKGIDQFGPPMIIHFRVQYYVEN--GRLISDRAARYYYYWHLRKQVLHSQCVLRE 141
            KKE          P+   FR +++ E+    LI +   R ++   +++ +L+ +     
Sbjct: 70  VKKEN---------PLQFKFRAKFFPEDVSEELIQEITQRLFFL-QVKEAILNDEIYCPP 119

Query: 142 EAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVS--KRGKDYILKHIPNMHKDQ 199
           E   LLA++A+QA  G++ +  H   Y   +   P  V+   K  K+   + I N H++ 
Sbjct: 120 ETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEH 179

Query: 200 FALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQ 259
             +   ++ ++Y+K A  L+   V+Y+ + K+K+  E  L LG+   G+ I+++ D++  
Sbjct: 180 RGMLREDSMMEYLKIAQDLEMYGVNYFEI-KNKKGTE--LWLGVDALGLNIYEH-DDKLT 235

Query: 260 LLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYMNL 319
               FPW+ +  + F  KKF I P     A   ++Y      ++ +L L   +H LYM  
Sbjct: 236 PKIGFPWSEIRNISFNDKKFVIKPID-KKAPDFVFYAPRLRINKRILALCMGNHELYMR- 293

Query: 320 QPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSR 359
               R    +E  + K Q RE      L+    + EK+ R
Sbjct: 294 ---RRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKR 330


>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 79/373 (21%), Positives = 164/373 (43%), Gaps = 37/373 (9%)

Query: 2   NKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSV 61
           ++++F + +  Q +      +  D  +     +K     L   VC  L L++   FGL  
Sbjct: 7   SRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY 66

Query: 62  IQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRL-ISDRAA 120
              +   ++++ +K+  +       + SK       P+  HF  ++Y EN    +     
Sbjct: 67  TIKDTVAWLKMDKKVLDH-------DVSKE-----EPVTFHFLAKFYPENAEEELVQEIT 114

Query: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180
           ++ ++  ++KQ+L  +     EA  LLA++A+QA  G++  + H   +   E   P  V+
Sbjct: 115 QHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVI 174

Query: 181 S--KRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEAS 238
           +  +   +   + I   + +       EA ++Y+K A  L+   V+Y+ + ++K+  E  
Sbjct: 175 NLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI-RNKKGTE-- 231

Query: 239 LTLGLTMRGIQIFQNLDEEKQLL--YDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYT 296
           L LG+   G+ I+   D E +L     FPW  +  + +  K+F I P  L     +  + 
Sbjct: 232 LLLGVDALGLHIY---DPENRLTPKISFPWNEIRNISYSDKEFTIKP--LDKKIDVFKFN 286

Query: 297 GCPMR-SRHLLQLLSNSHRLYM-----------NLQPVLRHIRKLEENEEKKQYRESYIS 344
              +R ++ +LQL   +H L+M            ++   R  +  ++ E ++  RE  + 
Sbjct: 287 SSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMR 346

Query: 345 DNLDLDMDQLEKR 357
           +  +   D+LE+R
Sbjct: 347 EEAERTRDELERR 359


>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 79/373 (21%), Positives = 164/373 (43%), Gaps = 37/373 (9%)

Query: 2   NKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSV 61
           ++++F + +  Q +      +  D  +     +K     L   VC  L L++   FGL  
Sbjct: 7   SRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY 66

Query: 62  IQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRL-ISDRAA 120
              +   ++++ +K+  +       + SK       P+  HF  ++Y EN    +     
Sbjct: 67  TIKDTVAWLKMDKKVLDH-------DVSKE-----EPVTFHFLAKFYPENAEEELVQEIT 114

Query: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180
           ++ ++  ++KQ+L  +     EA  LLA++A+QA  G++  + H   +   E   P  V+
Sbjct: 115 QHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVI 174

Query: 181 S--KRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEAS 238
           +  +   +   + I   + +       EA ++Y+K A  L+   V+Y+ + ++K+  E  
Sbjct: 175 NLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI-RNKKGTE-- 231

Query: 239 LTLGLTMRGIQIFQNLDEEKQLL--YDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYT 296
           L LG+   G+ I+   D E +L     FPW  +  + +  K+F I P  L     +  + 
Sbjct: 232 LLLGVDALGLHIY---DPENRLTPKISFPWNEIRNISYSDKEFTIKP--LDKKIDVFKFN 286

Query: 297 GCPMR-SRHLLQLLSNSHRLYM-----------NLQPVLRHIRKLEENEEKKQYRESYIS 344
              +R ++ +LQL   +H L+M            ++   R  +  ++ E ++  RE  + 
Sbjct: 287 SSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMR 346

Query: 345 DNLDLDMDQLEKR 357
           +  +   D+LE+R
Sbjct: 347 EEAERTRDELERR 359


>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 79/373 (21%), Positives = 164/373 (43%), Gaps = 37/373 (9%)

Query: 2   NKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSV 61
           ++++F + +  Q +      +  D  +     +K     L   VC  L L++   FGL  
Sbjct: 7   SRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY 66

Query: 62  IQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRL-ISDRAA 120
              +   ++++ +K+  +       + SK       P+  HF  ++Y EN    +     
Sbjct: 67  TIKDTVAWLKMDKKVLDH-------DVSKE-----EPVTFHFLAKFYPENAEEELVQEIT 114

Query: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180
           ++ ++  ++KQ+L  +     EA  LLA++A+QA  G++  + H   +   E   P  V+
Sbjct: 115 QHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVI 174

Query: 181 S--KRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEAS 238
           +  +   +   + I   + +       EA ++Y+K A  L+   V+Y+ + ++K+  E  
Sbjct: 175 NLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI-RNKKGTE-- 231

Query: 239 LTLGLTMRGIQIFQNLDEEKQLL--YDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYT 296
           L LG+   G+ I+   D E +L     FPW  +  + +  K+F I P  L     +  + 
Sbjct: 232 LLLGVDALGLHIY---DPENRLTPKISFPWNEIRNISYSDKEFTIKP--LDKKIDVFKFN 286

Query: 297 GCPMR-SRHLLQLLSNSHRLYM-----------NLQPVLRHIRKLEENEEKKQYRESYIS 344
              +R ++ +LQL   +H L+M            ++   R  +  ++ E ++  RE  + 
Sbjct: 287 SSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMR 346

Query: 345 DNLDLDMDQLEKR 357
           +  +   D+LE+R
Sbjct: 347 EEAERTRDELERR 359


>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
          Length = 595

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 79/373 (21%), Positives = 164/373 (43%), Gaps = 37/373 (9%)

Query: 2   NKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSV 61
           ++++F + +  Q +      +  D  +     +K     L   VC  L L++   FGL  
Sbjct: 7   SRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY 66

Query: 62  IQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRL-ISDRAA 120
              +   ++++ +K+  +       + SK       P+  HF  ++Y EN    +     
Sbjct: 67  TIKDTVAWLKMDKKVLDH-------DVSKE-----EPVTFHFLAKFYPENAEEELVQEIT 114

Query: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180
           ++ ++  ++KQ+L  +     EA  LLA++A+QA  G++  + H   +   E   P  V+
Sbjct: 115 QHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVI 174

Query: 181 S--KRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEAS 238
           +  +   +   + I   + +       EA ++Y+K A  L+   V+Y+ + ++K+  E  
Sbjct: 175 NLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI-RNKKGTE-- 231

Query: 239 LTLGLTMRGIQIFQNLDEEKQLL--YDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYT 296
           L LG+   G+ I+   D E +L     FPW  +  + +  K+F I P  L     +  + 
Sbjct: 232 LLLGVDALGLHIY---DPENRLTPKISFPWNEIRNISYSDKEFTIKP--LDKKIDVFKFN 286

Query: 297 GCPMR-SRHLLQLLSNSHRLYM-----------NLQPVLRHIRKLEENEEKKQYRESYIS 344
              +R ++ +LQL   +H L+M            ++   R  +  ++ E ++  RE  + 
Sbjct: 287 SSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMR 346

Query: 345 DNLDLDMDQLEKR 357
           +  +   D+LE+R
Sbjct: 347 EEAERTRDELERR 359


>gi|150010540 FERM domain containing 4B [Homo sapiens]
          Length = 1034

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 68/277 (24%), Positives = 128/277 (46%), Gaps = 27/277 (9%)

Query: 12  MQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNN-EHVYM 70
           M + R   + L +D  L +++  K+L  +LL  V     LK+   FG++ I +  +  ++
Sbjct: 55  MTEGRHCQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWL 114

Query: 71  ELSQKLYKY-CPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLR 129
           +L  ++  +  PK+              P I+HF V++Y+E+   + D+     ++ + +
Sbjct: 115 QLDHRVLDHDLPKK------------PGPTILHFAVRFYIESISFLKDKTTVELFFLNAK 162

Query: 130 KQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRG----- 184
             V   Q  +  E  F LAAF LQ   G++  +++  K  +    FP+  + +       
Sbjct: 163 ACVHKGQIEVESETIFKLAAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYC 222

Query: 185 KDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLT 244
           +D +++H   +      LT  +A ++Y+K    L    VHYY + KDK+ +     LG++
Sbjct: 223 EDRVIEHYLKIK----GLTRGQAVVQYMKIVEALPTYGVHYYAV-KDKQGL--PWWLGIS 275

Query: 245 MRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEI 281
            +GI  +   D+ K     F W  +  L F  KKF +
Sbjct: 276 YKGIGQYDIQDKVKPRKL-FQWKQLENLYFREKKFAV 311


>gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens]
          Length = 548

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 64/277 (23%), Positives = 128/277 (46%), Gaps = 25/277 (9%)

Query: 98  PMIIHFRVQYYVENGRL-ISDRAARYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADL 156
           P+  HF  ++Y EN    +     ++ ++  ++KQ+L  +     EA  LLA++A+QA  
Sbjct: 49  PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKY 108

Query: 157 GNFKRNKHYGKYFEPEAYFPSWVVS--KRGKDYILKHIPNMHKDQFALTASEAHLKYIKE 214
           G++  + H   +   E   P  V++  +   +   + I   + +       EA ++Y+K 
Sbjct: 109 GDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKI 168

Query: 215 AVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQLL--YDFPWTNVGKL 272
           A  L+   V+Y+ + ++K+  E  L LG+   G+ I+   D E +L     FPW  +  +
Sbjct: 169 AQDLEMYGVNYFAI-RNKKGTE--LLLGVDALGLHIY---DPENRLTPKISFPWNEIRNI 222

Query: 273 VFVGKKFEILPDGLPSARKLIYYTGCPMR-SRHLLQLLSNSHRLYM-----------NLQ 320
            +  K+F I P  L     +  +    +R ++ +LQL   +H L+M            ++
Sbjct: 223 SYSDKEFTIKP--LDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMK 280

Query: 321 PVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKR 357
              R  +  ++ E ++  RE  + +  +   D+LE+R
Sbjct: 281 AQAREEKARKQMERQRLAREKQMREEAERTRDELERR 317


>gi|34328899 protein tyrosine phosphatase, non-receptor type 14
           [Homo sapiens]
          Length = 1187

 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 63/298 (21%), Positives = 125/298 (41%), Gaps = 21/298 (7%)

Query: 20  IFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHV-YMELSQKLYK 78
           I L +   +   ++V+    + L  V   L L++ H FGL  +  ++   ++EL + L K
Sbjct: 25  IRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKK 84

Query: 79  YCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCV 138
           +            +D+F    ++ F V +YV N   +   A RY YY  ++K VL  +  
Sbjct: 85  H------------LDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLR 132

Query: 139 LREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIPNMHKD 198
              +    LA  A+QAD G++ +        E   +     + +   + + + +   HK 
Sbjct: 133 CTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKA 192

Query: 199 QFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEK 258
              +  +EA L YI E  RLD        ++  K      + LG+   GI +   +  + 
Sbjct: 193 HSGILPAEAELMYINEVERLDGFG---QEIFPVKDNHGNCVHLGIFFMGIFVRNRIGRQA 249

Query: 259 QLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLY 316
            +   + W ++G +     K  IL + +      +++T     ++++ +L +  H+ Y
Sbjct: 250 VI---YRWNDMGNITH--NKSTILVELINKEETALFHTDDIENAKYISRLFATRHKFY 302


>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
          Length = 570

 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 104/536 (19%), Positives = 207/536 (38%), Gaps = 69/536 (12%)

Query: 1   MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS 60
           +++L   ++R ++   S  + L +D      I        L   +C  L L +   FG+ 
Sbjct: 2   LSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIR 61

Query: 61  VIQ-NNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRA 119
            +  + +  ++E ++ + K    +             PP  + FRV++Y  +   + +  
Sbjct: 62  FVDPDKQRHWLEFTKSVVKQLRSQ-------------PPFTMCFRVKFYPADPAALKEEI 108

Query: 120 ARYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWV 179
            RY  +  +++ + H + + +     LLAA+ LQA++G++   KH      PE Y   + 
Sbjct: 109 TRYLVFLQIKRDLYHGRLLCKTSDAALLAAYILQAEIGDYDSGKH------PEGYSSKFQ 162

Query: 180 VSKRGKDYILKHIPNMHKDQFA-LTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEAS 238
              +  + + + I  +HK + +  T + + L ++++A  L+   V  +      +++  +
Sbjct: 163 FFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRKAQTLETYGVDPHPC----KDVSGN 218

Query: 239 LT-LGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLI-YYT 296
              L  T  G  + Q      + ++   W  V KL F GK F +        + ++ Y+ 
Sbjct: 219 AAFLAFTPFGFVVLQG----NKRVHFIKWNEVTKLKFEGKTFYLYVSQKEEKKIILTYFA 274

Query: 297 GCPMRSRHLLQL-----------LSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYISD 345
             P   +HL +             S+  R   +     +  R        K+  ES  S 
Sbjct: 275 PTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFRYSGRVAKEVMES--SA 332

Query: 346 NLDLDMDQLEKRSRASGSSAGSMKH-KRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSY 404
            +  +  ++ +       S  S+ H  RLS        + H S +E     RD+      
Sbjct: 333 KIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAVHISIMEGLESLRDSAHSTPV 392

Query: 405 SSSAIHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEES 464
            S             TSHG +    V S   D       ++ + ++ D     E  +   
Sbjct: 393 RS-------------TSHGDTFLPHVRSSRTD------SNERVAVIAD-----EAYSPAD 428

Query: 465 LEVSPDMCIYITEDMLMSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQ 520
             +   +  +  E ML+SR++NG +  I +E  S  S+ + T V+  G    +L Q
Sbjct: 429 SVLPTPVAEHSLELMLLSRQINGATCSIEEEKESEASTPTATEVEALGGELRALCQ 484


>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
           sapiens]
          Length = 926

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 49/188 (26%), Positives = 96/188 (51%), Gaps = 17/188 (9%)

Query: 96  GPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQAD 155
           G P  ++FRV+++V +   + +   RY Y+  +++ +L  +         LLA+FA+Q++
Sbjct: 98  GSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSE 157

Query: 156 LGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEA 215
           LG++ ++++   Y    ++ P+     + +D+  K I  +H+    L+ +EA   Y+  A
Sbjct: 158 LGDYDQSENLSGYLSDYSFIPN-----QPQDF-EKEIAKLHQQHIGLSPAEAEFNYLNTA 211

Query: 216 --VRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLV 273
             + L  V  HY R   D+   E  + +G+   GI I++N    +  +  FPW  + K+ 
Sbjct: 212 RTLELYGVEFHYAR---DQSNNE--IMIGVMSGGILIYKN----RVRMNTFPWLKIVKIS 262

Query: 274 FVGKKFEI 281
           F  K+F I
Sbjct: 263 FKCKQFFI 270


>gi|116063562 FERM domain containing 4A [Homo sapiens]
          Length = 1039

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 70/325 (21%), Positives = 144/325 (44%), Gaps = 36/325 (11%)

Query: 11  VMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHV-Y 69
           +M + R   + L +D  L +++  K+L  +LL  V     LK+   FG++      H+ +
Sbjct: 15  MMTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNW 74

Query: 70  MELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLR 129
           ++L +++ ++   ++ K++         P++++F V++Y+E+   + D A    ++ + +
Sbjct: 75  LQLDRRVLEH---DFPKKSG--------PVVLYFCVRFYIESISYLKDNATIELFFLNAK 123

Query: 130 KQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRG----- 184
             +      +  E  F LA++ LQ   G+F  N+      +     P+  + +       
Sbjct: 124 SCIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYC 183

Query: 185 KDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLT 244
           +D +++H    +K     T  +A + Y+     L    VHYY + KDK+ I     LGL+
Sbjct: 184 EDRVIEH----YKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAV-KDKQGI--PWWLGLS 236

Query: 245 MRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEIL---PDGLPSARKLIYYTG---- 297
            +GI  +   D+ K     F W  +  L F  KKF +    P      R+   ++G    
Sbjct: 237 YKGIFQYDYHDKVKPRKI-FQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVH 295

Query: 298 ----CPMRSRHLLQLLSNSHRLYMN 318
               CP   + +  +  + H+ Y++
Sbjct: 296 TWYACPALIKSIWAMAISQHQFYLD 320



 Score = 30.8 bits (68), Expect = 3.8
 Identities = 22/58 (37%), Positives = 27/58 (46%), Gaps = 8/58 (13%)

Query: 376 HSTASHSSSHTSGIEADTK----PRDTGPEDSYS----SSAIHRKLKTCSSMTSHGSS 425
           HS A H    +S +E+  K      DTG  D Y+    SS     +  CSS TSH SS
Sbjct: 699 HSLALHFRHRSSSLESQGKLLGSENDTGSPDFYTPRTRSSNGSDPMDDCSSCTSHSSS 756


>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
          Length = 686

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 51/213 (23%), Positives = 100/213 (46%), Gaps = 14/213 (6%)

Query: 69  YMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHL 128
           Y + S + Y   P +   E  + I+  GPP  ++F +++Y E+   + +   RY ++  +
Sbjct: 61  YCDRSHQTYWLDPAKTLAEHKELINT-GPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQV 119

Query: 129 RKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYI 188
           ++ VL  +          L A+A+Q++LG++   KH   Y     + P        K+ +
Sbjct: 120 KQDVLQGRLPCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPD------QKEEL 173

Query: 189 LKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGI 248
            + I  +HK       SEA L Y++ A  L+   V  + +Y + +   +   LGLT  G+
Sbjct: 174 EEAIERIHKTLMGQIPSEAELNYLRTAKSLEMYGVDLHPVYGENK---SEYFLGLTPVGV 230

Query: 249 QIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEI 281
            +++N    K+ +  + W  + K+ F   +FE+
Sbjct: 231 VVYKN----KKQVGKYFWPRITKVHFKETQFEL 259


>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
           isoform 2 [Homo sapiens]
          Length = 868

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 50/199 (25%), Positives = 93/199 (46%), Gaps = 18/199 (9%)

Query: 87  EASKGIDQF---GPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCVLREEA 143
           EASK I +    G P  +HFRV++++ +   +     R+ Y+  L+  +   +      +
Sbjct: 86  EASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNS 145

Query: 144 YFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIPNMHKDQFALT 203
             +LA++A+Q+  G++  + H+  Y     + P      + +D++ K + ++H+    L 
Sbjct: 146 AVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPD-----QNEDFLTK-VESLHEQHSGLK 199

Query: 204 ASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQLLYD 263
            SEA   YI  A  LD   V    L+  +      L +G+   G+ +++     K +   
Sbjct: 200 QSEAESCYINIARTLDFYGVE---LHSGRDLHNLDLMIGIASAGVAVYR-----KYICTS 251

Query: 264 F-PWTNVGKLVFVGKKFEI 281
           F PW N+ K+ F  KKF I
Sbjct: 252 FYPWVNILKISFKRKKFFI 270


>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
           isoform 1 [Homo sapiens]
          Length = 913

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 50/199 (25%), Positives = 93/199 (46%), Gaps = 18/199 (9%)

Query: 87  EASKGIDQF---GPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCVLREEA 143
           EASK I +    G P  +HFRV++++ +   +     R+ Y+  L+  +   +      +
Sbjct: 86  EASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNS 145

Query: 144 YFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIPNMHKDQFALT 203
             +LA++A+Q+  G++  + H+  Y     + P      + +D++ K + ++H+    L 
Sbjct: 146 AVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPD-----QNEDFLTK-VESLHEQHSGLK 199

Query: 204 ASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQLLYD 263
            SEA   YI  A  LD   V    L+  +      L +G+   G+ +++     K +   
Sbjct: 200 QSEAESCYINIARTLDFYGVE---LHSGRDLHNLDLMIGIASAGVAVYR-----KYICTS 251

Query: 264 F-PWTNVGKLVFVGKKFEI 281
           F PW N+ K+ F  KKF I
Sbjct: 252 FYPWVNILKISFKRKKFFI 270


>gi|117500790 FERM domain containing 3 [Homo sapiens]
          Length = 597

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 65/311 (20%), Positives = 127/311 (40%), Gaps = 34/311 (10%)

Query: 1   MNKLNFHNNRV--MQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFG 58
           M  ++F ++ V  +       I L +D  ++  I  +     L+  +C+   L +   FG
Sbjct: 15  MKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFG 74

Query: 59  LSVIQ-NNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISD 117
           +  +    +  ++E ++ ++K                  PP  + FRV++Y      I +
Sbjct: 75  IRYVDPEKQRHWLEPNKSIFKQMKTH-------------PPYTMCFRVKFYPHEPLKIKE 121

Query: 118 RAARYYYYWHLRKQVLHSQ--CVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYF 175
              RY  Y  +++ + H +  C   + AY  L A  +QA+LG++  ++H      PE Y 
Sbjct: 122 ELTRYLLYLQIKRDIFHGRLLCSFSDAAY--LGACIVQAELGDYDPDEH------PENYI 173

Query: 176 PSWVVSKRGKDYILKHIPNMHKDQF-ALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKRE 234
             + +  +    + + I  +HK++    +   A    + +A  L+   V  +     K  
Sbjct: 174 SEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAHTLETYGVDPHPC---KDS 230

Query: 235 IEASLTLGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIY 294
              +  LG T  G  +FQ      + ++   W +V KL F GK F ++         L +
Sbjct: 231 TGTTTFLGFTAAGFVVFQG----NKRIHLIKWPDVCKLKFEGKTFYVIGTQKEKKAMLAF 286

Query: 295 YTGCPMRSRHL 305
           +T  P   +HL
Sbjct: 287 HTSTPAACKHL 297


>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
           [Homo sapiens]
          Length = 1174

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 56/230 (24%), Positives = 104/230 (45%), Gaps = 16/230 (6%)

Query: 20  IFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELSQKLYKY 79
           I L N+E +   ++V+    + L  V   L L++   F L         Y + +Q+ +  
Sbjct: 27  IQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSL-------WYYNKQNQRRWVD 79

Query: 80  CPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCVL 139
             K  KK+    +D++     ++F V +YV +   +     RY YY  L+K +L      
Sbjct: 80  LEKPLKKQ----LDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPC 135

Query: 140 REEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFP-SWVVSKRGKDYILKHIPNMHKD 198
             E    LA  A+QAD G+F + +    + +  A FP  W+  ++  +   + +  +H+ 
Sbjct: 136 TLEQAIQLAGLAVQADFGDFDQYESQ-DFLQKFALFPVGWLQDEKVLEEATQKVALLHQK 194

Query: 199 QFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGI 248
              LTA +A + Y++E  R+D      Y   KD +   + +++G  + GI
Sbjct: 195 YRGLTAPDAEMLYMQEVERMDGYGEESYPA-KDSQ--GSDISIGACLEGI 241


>gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens]
          Length = 507

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 58/246 (23%), Positives = 114/246 (46%), Gaps = 24/246 (9%)

Query: 128 LRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVS--KRGK 185
           ++KQ+L  +     EA  LLA++A+QA  G++  + H   +   E   P  V++  +   
Sbjct: 39  VKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTP 98

Query: 186 DYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTM 245
           +   + I   + +       EA ++Y+K A  L+   V+Y+ + ++K+  E  L LG+  
Sbjct: 99  EMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI-RNKKGTE--LLLGVDA 155

Query: 246 RGIQIFQNLDEEKQLL--YDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMR-S 302
            G+ I+   D E +L     FPW  +  + +  K+F I P  L     +  +    +R +
Sbjct: 156 LGLHIY---DPENRLTPKISFPWNEIRNISYSDKEFTIKP--LDKKIDVFKFNSSKLRVN 210

Query: 303 RHLLQLLSNSHRLYM-----------NLQPVLRHIRKLEENEEKKQYRESYISDNLDLDM 351
           + +LQL   +H L+M            ++   R  +  ++ E ++  RE  + +  +   
Sbjct: 211 KLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTR 270

Query: 352 DQLEKR 357
           D+LE+R
Sbjct: 271 DELERR 276


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,432,397
Number of Sequences: 37866
Number of extensions: 1061331
Number of successful extensions: 4558
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 115
Number of HSP's that attempted gapping in prelim test: 4169
Number of HSP's gapped (non-prelim): 339
length of query: 614
length of database: 18,247,518
effective HSP length: 108
effective length of query: 506
effective length of database: 14,157,990
effective search space: 7163942940
effective search space used: 7163942940
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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