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Search of human proteins with 22748721
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22748721 FERM domain containing 6 [Homo sapiens]
(614 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109715866 FERM domain containing 6 [Homo sapiens] 1248 0.0
gi|22748721 FERM domain containing 6 [Homo sapiens] 1248 0.0
gi|170932510 FERM domain containing 1 isoform 1 [Homo sapiens] 379 e-105
gi|170932512 FERM domain containing 1 isoform 2 [Homo sapiens] 365 e-101
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 150 4e-36
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 150 4e-36
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 150 4e-36
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 147 2e-35
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 125 1e-28
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 125 1e-28
gi|4505257 moesin [Homo sapiens] 91 2e-18
gi|161702986 ezrin [Homo sapiens] 91 3e-18
gi|21614499 ezrin [Homo sapiens] 91 3e-18
gi|4506467 radixin [Homo sapiens] 91 4e-18
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 83 6e-16
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 83 6e-16
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 83 6e-16
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 83 6e-16
gi|150010540 FERM domain containing 4B [Homo sapiens] 80 4e-15
gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens] 77 5e-14
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [... 77 6e-14
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 77 6e-14
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 75 2e-13
gi|116063562 FERM domain containing 4A [Homo sapiens] 75 2e-13
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 75 2e-13
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 72 2e-12
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 72 2e-12
gi|117500790 FERM domain containing 3 [Homo sapiens] 69 1e-11
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 68 2e-11
gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens] 66 1e-10
>gi|109715866 FERM domain containing 6 [Homo sapiens]
Length = 614
Score = 1248 bits (3230), Expect = 0.0
Identities = 614/614 (100%), Positives = 614/614 (100%)
Query: 1 MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS 60
MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS
Sbjct: 1 MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS 60
Query: 61 VIQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAA 120
VIQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAA
Sbjct: 61 VIQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAA 120
Query: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180
RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV
Sbjct: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180
Query: 181 SKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLT 240
SKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLT
Sbjct: 181 SKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLT 240
Query: 241 LGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPM 300
LGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPM
Sbjct: 241 LGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPM 300
Query: 301 RSRHLLQLLSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRA 360
RSRHLLQLLSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRA
Sbjct: 301 RSRHLLQLLSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRA 360
Query: 361 SGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMT 420
SGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMT
Sbjct: 361 SGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMT 420
Query: 421 SHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDML 480
SHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDML
Sbjct: 421 SHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDML 480
Query: 481 MSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDI 540
MSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDI
Sbjct: 481 MSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDI 540
Query: 541 RLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYF 600
RLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYF
Sbjct: 541 RLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYF 600
Query: 601 SLDLTHDEVPEFVV 614
SLDLTHDEVPEFVV
Sbjct: 601 SLDLTHDEVPEFVV 614
>gi|22748721 FERM domain containing 6 [Homo sapiens]
Length = 614
Score = 1248 bits (3230), Expect = 0.0
Identities = 614/614 (100%), Positives = 614/614 (100%)
Query: 1 MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS 60
MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS
Sbjct: 1 MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS 60
Query: 61 VIQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAA 120
VIQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAA
Sbjct: 61 VIQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAA 120
Query: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180
RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV
Sbjct: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180
Query: 181 SKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLT 240
SKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLT
Sbjct: 181 SKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLT 240
Query: 241 LGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPM 300
LGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPM
Sbjct: 241 LGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPM 300
Query: 301 RSRHLLQLLSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRA 360
RSRHLLQLLSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRA
Sbjct: 301 RSRHLLQLLSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRA 360
Query: 361 SGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMT 420
SGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMT
Sbjct: 361 SGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMT 420
Query: 421 SHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDML 480
SHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDML
Sbjct: 421 SHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDML 480
Query: 481 MSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDI 540
MSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDI
Sbjct: 481 MSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDI 540
Query: 541 RLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYF 600
RLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYF
Sbjct: 541 RLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYF 600
Query: 601 SLDLTHDEVPEFVV 614
SLDLTHDEVPEFVV
Sbjct: 601 SLDLTHDEVPEFVV 614
>gi|170932510 FERM domain containing 1 isoform 1 [Homo sapiens]
Length = 549
Score = 379 bits (973), Expect = e-105
Identities = 232/602 (38%), Positives = 331/602 (54%), Gaps = 105/602 (17%)
Query: 14 DRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELS 73
+ R V + LP+ E L + + VK +L QVC++ ++D FGL V++NNE+++M+L
Sbjct: 52 EHRDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLE 111
Query: 74 QKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVL 133
QKL KY K+WKKE ++G ++ P + RVQ+YVENGR+ISD AR+ YY HL+++VL
Sbjct: 112 QKLSKYFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVL 171
Query: 134 HSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIP 193
SQC REEAYFLLAA ALQADLG + + H G+YFEP +YFP W+++KRG DYIL+H+P
Sbjct: 172 RSQCAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMP 231
Query: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
+H+++ L+ EA L +I+EA RL+DV VH++RL+KDK+E ++ LGL +RG+ I+Q
Sbjct: 232 TLHRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ- 290
Query: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSH 313
GKK EI DGLP+A+KL+YYTGC RSRHLL LL SH
Sbjct: 291 ----------------------GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASH 328
Query: 314 RLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRASGSSAGSMKHKRL 373
+L++ ++P L+ +R+ EE EEK+ YRESYISD L+LD+ AS S GS +
Sbjct: 329 QLHLRVRPTLQQLRQREEAEEKQHYRESYISDELELDL--------ASRSFPGSGVSSQH 380
Query: 374 SRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMTSHGSSHTSGVESG 433
H + HS+ SHGSS+TSG+++
Sbjct: 381 CPHCLSRHSAD------------------------------------SHGSSYTSGIKAN 404
Query: 434 GKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDMLMSRKLNGHSGLIV 493
R + EM VD P ++ ++E+ SP R H
Sbjct: 405 SWLR-------ESREMSVDVPLEVHGLHEKEPSSSP-------------RTSRSHPS--T 442
Query: 494 KEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGL 553
+ +T T V+ RGQS +++ Q S ++HS LDD++L+Q +A
Sbjct: 443 RGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQHSHGLDDMQLHQ-----LALH 497
Query: 554 CQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFPVKRTSKYFSLDLTHDEVP-EF 612
T+ S+TF L C LA C + P KR+S +LDL + P EF
Sbjct: 498 PAPTSLSHTF-------HRALDCR--LAGPC-ETRATLPSKRSSNCLALDLFGEAPPQEF 547
Query: 613 VV 614
VV
Sbjct: 548 VV 549
>gi|170932512 FERM domain containing 1 isoform 2 [Homo sapiens]
Length = 481
Score = 365 bits (938), Expect = e-101
Identities = 226/583 (38%), Positives = 321/583 (55%), Gaps = 105/583 (18%)
Query: 33 NVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELSQKLYKYCPKEWKKEASKGI 92
+VK +L QVC++ ++D FGL V++NNE+++M+L QKL KY K+WKKE ++G
Sbjct: 3 DVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGN 62
Query: 93 DQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCVLREEAYFLLAAFAL 152
++ P + RVQ+YVENGR+ISD AR+ YY HL+++VL SQC REEAYFLLAA AL
Sbjct: 63 EKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREEAYFLLAACAL 122
Query: 153 QADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIPNMHKDQFALTASEAHLKYI 212
QADLG + + H G+YFEP +YFP W+++KRG DYIL+H+P +H+++ L+ EA L +I
Sbjct: 123 QADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGLSPKEAMLCFI 182
Query: 213 KEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKL 272
+EA RL+DV VH++RL+KDK+E ++ LGL +RG+ I+Q
Sbjct: 183 QEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQ-------------------- 222
Query: 273 VFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYMNLQPVLRHIRKLEEN 332
GKK EI DGLP+A+KL+YYTGC RSRHLL LL SH+L++ ++P L+ +R+ EE
Sbjct: 223 ---GKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEA 279
Query: 333 EEKKQYRESYISDNLDLDMDQLEKRSRASGSSAGSMKHKRLSRHSTASHSSSHTSGIEAD 392
EEK+ YRESYISD L+LD+ AS S GS + H + HS+
Sbjct: 280 EEKQHYRESYISDELELDL--------ASRSFPGSGVSSQHCPHCLSRHSAD-------- 323
Query: 393 TKPRDTGPEDSYSSSAIHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDLQDDEIEMLVD 452
SHGSS+TSG+++ R + EM VD
Sbjct: 324 ----------------------------SHGSSYTSGIKANSWLR-------ESREMSVD 348
Query: 453 DPRDLEQMNEESLEVSPDMCIYITEDMLMSRKLNGHSGLIVKEIGSSTSSSSETVVKLRG 512
P ++ ++E+ SP R H + +T T V+ RG
Sbjct: 349 VPLEVHGLHEKEPSSSP-------------RTSRSHPS--TRGDSQATRQEPCTQVRTRG 393
Query: 513 QSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHELDEE 572
QS +++ Q S ++HS LDD++L+Q +A T+ S+TF
Sbjct: 394 QSAEAVHQIQEMTAGVSEEQHSHGLDDMQLHQ-----LALHPAPTSLSHTF-------HR 441
Query: 573 GLYCNSCLAQQCINIQDAFPVKRTSKYFSLDLTHDEVP-EFVV 614
L C LA C + P KR+S +LDL + P EFVV
Sbjct: 442 ALDCR--LAGPC-ETRATLPSKRSSNCLALDLFGEAPPQEFVV 481
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 150 bits (378), Expect = 4e-36
Identities = 100/363 (27%), Positives = 180/363 (49%), Gaps = 18/363 (4%)
Query: 14 DRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELS 73
+RR V I L N + L + + K +C + V + L + HLF L+ +++NE+ +++
Sbjct: 570 NRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPD 629
Query: 74 QKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVL 133
KL K P+ WK+E K + + FR+++++++ LI + YY LRK +L
Sbjct: 630 LKLTKVAPEGWKEEPKKKT-KATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDIL 688
Query: 134 HSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIP 193
+ +E LLA+ ALQA+ G+++ H YF E Y P+ V+ K YI + +P
Sbjct: 689 EERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELP 748
Query: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
+H + E L+++K RL + VH++R++ +K+ + + LG+ +G+ +F+
Sbjct: 749 KLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKS-QTGILLGVCSKGVLVFEV 807
Query: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEI--LPDGLPSARKLIYYTGCPMRSRHLLQLLSN 311
+ + L+ FPW K+ F KK + DG+ K + T ++LL L S
Sbjct: 808 HNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGI----KHGFQTDNSKICQYLLHLCSY 863
Query: 312 SHRLYMNLQPVLRHIRKLEENEEKKQY-RESYISDNLDLDMDQLEKRSRA--SGSSAGSM 368
H+ + + R + N++ + R S+ S NL + + RA +GS A S
Sbjct: 864 QHKFQLQM-------RARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASST 916
Query: 369 KHK 371
+K
Sbjct: 917 LNK 919
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 150 bits (378), Expect = 4e-36
Identities = 100/363 (27%), Positives = 180/363 (49%), Gaps = 18/363 (4%)
Query: 14 DRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELS 73
+RR V I L N + L + + K +C + V + L + HLF L+ +++NE+ +++
Sbjct: 570 NRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPD 629
Query: 74 QKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVL 133
KL K P+ WK+E K + + FR+++++++ LI + YY LRK +L
Sbjct: 630 LKLTKVAPEGWKEEPKKKT-KATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDIL 688
Query: 134 HSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIP 193
+ +E LLA+ ALQA+ G+++ H YF E Y P+ V+ K YI + +P
Sbjct: 689 EERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELP 748
Query: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
+H + E L+++K RL + VH++R++ +K+ + + LG+ +G+ +F+
Sbjct: 749 KLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKS-QTGILLGVCSKGVLVFEV 807
Query: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEI--LPDGLPSARKLIYYTGCPMRSRHLLQLLSN 311
+ + L+ FPW K+ F KK + DG+ K + T ++LL L S
Sbjct: 808 HNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGI----KHGFQTDNSKICQYLLHLCSY 863
Query: 312 SHRLYMNLQPVLRHIRKLEENEEKKQY-RESYISDNLDLDMDQLEKRSRA--SGSSAGSM 368
H+ + + R + N++ + R S+ S NL + + RA +GS A S
Sbjct: 864 QHKFQLQM-------RARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASST 916
Query: 369 KHK 371
+K
Sbjct: 917 LNK 919
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13
isoform 2 [Homo sapiens]
Length = 2466
Score = 150 bits (378), Expect = 4e-36
Identities = 100/363 (27%), Positives = 180/363 (49%), Gaps = 18/363 (4%)
Query: 14 DRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELS 73
+RR V I L N + L + + K +C + V + L + HLF L+ +++NE+ +++
Sbjct: 570 NRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPD 629
Query: 74 QKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVL 133
KL K P+ WK+E K + + FR+++++++ LI + YY LRK +L
Sbjct: 630 LKLTKVAPEGWKEEPKKKT-KATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDIL 688
Query: 134 HSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIP 193
+ +E LLA+ ALQA+ G+++ H YF E Y P+ V+ K YI + +P
Sbjct: 689 EERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELP 748
Query: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
+H + E L+++K RL + VH++R++ +K+ + + LG+ +G+ +F+
Sbjct: 749 KLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKS-QTGILLGVCSKGVLVFEV 807
Query: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEI--LPDGLPSARKLIYYTGCPMRSRHLLQLLSN 311
+ + L+ FPW K+ F KK + DG+ K + T ++LL L S
Sbjct: 808 HNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGI----KHGFQTDNSKICQYLLHLCSY 863
Query: 312 SHRLYMNLQPVLRHIRKLEENEEKKQY-RESYISDNLDLDMDQLEKRSRA--SGSSAGSM 368
H+ + + R + N++ + R S+ S NL + + RA +GS A S
Sbjct: 864 QHKFQLQM-------RARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASST 916
Query: 369 KHK 371
+K
Sbjct: 917 LNK 919
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 147 bits (372), Expect = 2e-35
Identities = 86/309 (27%), Positives = 158/309 (51%), Gaps = 8/309 (2%)
Query: 14 DRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELS 73
+RR V I L N + L + + K +C + V + L + HLF L+ +++NE+ +++
Sbjct: 570 NRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPD 629
Query: 74 QKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVL 133
KL K P+ WK+E K + + FR+++++++ LI + YY LRK +L
Sbjct: 630 LKLTKVAPEGWKEEPKKKT-KATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDIL 688
Query: 134 HSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIP 193
+ +E LLA+ ALQA+ G+++ H YF E Y P+ V+ K YI + +P
Sbjct: 689 EERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELP 748
Query: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
+H + E L+++K RL + VH++R++ +K+ + + LG+ +G+ +F+
Sbjct: 749 KLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKS-QTGILLGVCSKGVLVFEV 807
Query: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEI--LPDGLPSARKLIYYTGCPMRSRHLLQLLSN 311
+ + L+ FPW K+ F KK + DG+ K + T ++LL L S
Sbjct: 808 HNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGI----KHGFQTDNSKICQYLLHLCSY 863
Query: 312 SHRLYMNLQ 320
H+ + ++
Sbjct: 864 QHKFQLQMR 872
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 125 bits (313), Expect = 1e-28
Identities = 73/300 (24%), Positives = 145/300 (48%), Gaps = 8/300 (2%)
Query: 16 RSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELSQK 75
R +C+ L N + L + +V+ + V L++ FGL+ +++ E +++ +
Sbjct: 320 RDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETR 379
Query: 76 LYKYCPKEWKKEASK-GIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLH 134
L K P+ W+++ K ++ F + R++++V + L+ R+ +Y LRK +L
Sbjct: 380 LCKIAPEGWREQPQKTSMNTF----TLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILE 435
Query: 135 SQCVLREEAYFLLAAFALQADLGNFKRNKHYGK-YFEPEAYFPSWVVSKRGKDYILKHIP 193
+ EE L ALQA+ GN+ + + K YF E Y P+ ++ + + +
Sbjct: 436 ERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVS 495
Query: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
MH+ AL +A LK+++ +L + V ++++ +KR E + LG+ +G+ +++
Sbjct: 496 EMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEV 555
Query: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSH 313
+ + + F W GK+ KKF I + +K + T S++LL L S H
Sbjct: 556 KNNSRIAMLRFQWRETGKISTYQKKFTITSS--VTGKKHTFVTDSAKTSKYLLDLCSAQH 613
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 125 bits (313), Expect = 1e-28
Identities = 73/300 (24%), Positives = 145/300 (48%), Gaps = 8/300 (2%)
Query: 16 RSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELSQK 75
R +C+ L N + L + +V+ + V L++ FGL+ +++ E +++ +
Sbjct: 342 RDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETR 401
Query: 76 LYKYCPKEWKKEASK-GIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLH 134
L K P+ W+++ K ++ F + R++++V + L+ R+ +Y LRK +L
Sbjct: 402 LCKIAPEGWREQPQKTSMNTF----TLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILE 457
Query: 135 SQCVLREEAYFLLAAFALQADLGNFKRNKHYGK-YFEPEAYFPSWVVSKRGKDYILKHIP 193
+ EE L ALQA+ GN+ + + K YF E Y P+ ++ + + +
Sbjct: 458 ERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVS 517
Query: 194 NMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQN 253
MH+ AL +A LK+++ +L + V ++++ +KR E + LG+ +G+ +++
Sbjct: 518 EMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEV 577
Query: 254 LDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSH 313
+ + + F W GK+ KKF I + +K + T S++LL L S H
Sbjct: 578 KNNSRIAMLRFQWRETGKISTYQKKFTITSS--VTGKKHTFVTDSAKTSKYLLDLCSAQH 635
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 91.3 bits (225), Expect = 2e-18
Identities = 86/340 (25%), Positives = 152/340 (44%), Gaps = 27/340 (7%)
Query: 25 DESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEH-VYMELSQKLYKYCPKE 83
D L I QL QV + L++ FGL +++L++K+ ++
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKV---TAQD 69
Query: 84 WKKEASKGIDQFGPPMIIHFRVQYYVEN--GRLISDRAARYYYYWHLRKQVLHSQCVLRE 141
+KE+ P++ FR ++Y E+ LI D R ++ +++ +L+
Sbjct: 70 VRKES---------PLLFKFRAKFYPEDVSEELIQDITQRLFFL-QVKEGILNDDIYCPP 119
Query: 142 EAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVS--KRGKDYILKHIPNMHKDQ 199
E LLA++A+Q+ G+F + H Y + P V+ K KD + I H++
Sbjct: 120 ETAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEH 179
Query: 200 FALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQ 259
+ +A L+Y+K A L+ V+Y+ + K+K+ E L LG+ G+ I++ D
Sbjct: 180 RGMLREDAVLEYLKIAQDLEMYGVNYFSI-KNKKGSE--LWLGVDALGLNIYEQNDRLTP 236
Query: 260 LLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYMNL 319
+ FPW+ + + F KKF I P A ++Y ++ +L L +H LYM
Sbjct: 237 KI-GFPWSEIRNISFNDKKFVIKPID-KKAPDFVFYAPRLRINKRILALCMGNHELYMR- 293
Query: 320 QPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSR 359
R +E + K Q RE ++ M + EK+ R
Sbjct: 294 ---RRKPDTIEVQQMKAQAREEKHQKQMERAMLENEKKKR 330
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 90.9 bits (224), Expect = 3e-18
Identities = 84/340 (24%), Positives = 145/340 (42%), Gaps = 27/340 (7%)
Query: 25 DESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEH-VYMELSQKLYKYCPKE 83
D L I QL QV + L++ FGL + N +++L +K+ +E
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKV---SAQE 69
Query: 84 WKKEASKGIDQFGPPMIIHFRVQYYVEN--GRLISDRAARYYYYWHLRKQVLHSQCVLRE 141
+KE P+ FR ++Y E+ LI D + ++ +++ +L +
Sbjct: 70 VRKEN---------PLQFKFRAKFYPEDVAEELIQDITQKLFFL-QVKEGILSDEIYCPP 119
Query: 142 EAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVS--KRGKDYILKHIPNMHKDQ 199
E LL ++A+QA G++ + H Y E P V+ K +D I H +
Sbjct: 120 ETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEH 179
Query: 200 FALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQ 259
+ A L+Y+K A L+ ++Y+ + K + L LG+ G+ I++ D++
Sbjct: 180 RGMLKDNAMLEYLKIAQDLEMYGINYFEI---KNKKGTDLWLGVDALGLNIYEK-DDKLT 235
Query: 260 LLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYMNL 319
FPW+ + + F KKF I P A ++Y ++ +LQL +H LYM
Sbjct: 236 PKIGFPWSEIRNISFNDKKFVIKPID-KKAPDFVFYAPRLRINKRILQLCMGNHELYMR- 293
Query: 320 QPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSR 359
R +E + K Q RE L+ + EK+ R
Sbjct: 294 ---RRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRR 330
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 90.9 bits (224), Expect = 3e-18
Identities = 84/340 (24%), Positives = 145/340 (42%), Gaps = 27/340 (7%)
Query: 25 DESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEH-VYMELSQKLYKYCPKE 83
D L I QL QV + L++ FGL + N +++L +K+ +E
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKV---SAQE 69
Query: 84 WKKEASKGIDQFGPPMIIHFRVQYYVEN--GRLISDRAARYYYYWHLRKQVLHSQCVLRE 141
+KE P+ FR ++Y E+ LI D + ++ +++ +L +
Sbjct: 70 VRKEN---------PLQFKFRAKFYPEDVAEELIQDITQKLFFL-QVKEGILSDEIYCPP 119
Query: 142 EAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVS--KRGKDYILKHIPNMHKDQ 199
E LL ++A+QA G++ + H Y E P V+ K +D I H +
Sbjct: 120 ETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEH 179
Query: 200 FALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQ 259
+ A L+Y+K A L+ ++Y+ + K + L LG+ G+ I++ D++
Sbjct: 180 RGMLKDNAMLEYLKIAQDLEMYGINYFEI---KNKKGTDLWLGVDALGLNIYEK-DDKLT 235
Query: 260 LLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYMNL 319
FPW+ + + F KKF I P A ++Y ++ +LQL +H LYM
Sbjct: 236 PKIGFPWSEIRNISFNDKKFVIKPID-KKAPDFVFYAPRLRINKRILQLCMGNHELYMR- 293
Query: 320 QPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSR 359
R +E + K Q RE L+ + EK+ R
Sbjct: 294 ---RRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRR 330
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 90.5 bits (223), Expect = 4e-18
Identities = 83/340 (24%), Positives = 157/340 (46%), Gaps = 27/340 (7%)
Query: 25 DESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEH-VYMELSQKLYKYCPKE 83
D L I QL QV + L++ FGL + + + +++L++K+ + ++
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQ---QD 69
Query: 84 WKKEASKGIDQFGPPMIIHFRVQYYVEN--GRLISDRAARYYYYWHLRKQVLHSQCVLRE 141
KKE P+ FR +++ E+ LI + R ++ +++ +L+ +
Sbjct: 70 VKKEN---------PLQFKFRAKFFPEDVSEELIQEITQRLFFL-QVKEAILNDEIYCPP 119
Query: 142 EAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVS--KRGKDYILKHIPNMHKDQ 199
E LLA++A+QA G++ + H Y + P V+ K K+ + I N H++
Sbjct: 120 ETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEH 179
Query: 200 FALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQ 259
+ ++ ++Y+K A L+ V+Y+ + K+K+ E L LG+ G+ I+++ D++
Sbjct: 180 RGMLREDSMMEYLKIAQDLEMYGVNYFEI-KNKKGTE--LWLGVDALGLNIYEH-DDKLT 235
Query: 260 LLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYMNL 319
FPW+ + + F KKF I P A ++Y ++ +L L +H LYM
Sbjct: 236 PKIGFPWSEIRNISFNDKKFVIKPID-KKAPDFVFYAPRLRINKRILALCMGNHELYMR- 293
Query: 320 QPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSR 359
R +E + K Q RE L+ + EK+ R
Sbjct: 294 ---RRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKR 330
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 83.2 bits (204), Expect = 6e-16
Identities = 79/373 (21%), Positives = 164/373 (43%), Gaps = 37/373 (9%)
Query: 2 NKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSV 61
++++F + + Q + + D + +K L VC L L++ FGL
Sbjct: 7 SRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY 66
Query: 62 IQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRL-ISDRAA 120
+ ++++ +K+ + + SK P+ HF ++Y EN +
Sbjct: 67 TIKDTVAWLKMDKKVLDH-------DVSKE-----EPVTFHFLAKFYPENAEEELVQEIT 114
Query: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180
++ ++ ++KQ+L + EA LLA++A+QA G++ + H + E P V+
Sbjct: 115 QHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVI 174
Query: 181 S--KRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEAS 238
+ + + + I + + EA ++Y+K A L+ V+Y+ + ++K+ E
Sbjct: 175 NLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI-RNKKGTE-- 231
Query: 239 LTLGLTMRGIQIFQNLDEEKQLL--YDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYT 296
L LG+ G+ I+ D E +L FPW + + + K+F I P L + +
Sbjct: 232 LLLGVDALGLHIY---DPENRLTPKISFPWNEIRNISYSDKEFTIKP--LDKKIDVFKFN 286
Query: 297 GCPMR-SRHLLQLLSNSHRLYM-----------NLQPVLRHIRKLEENEEKKQYRESYIS 344
+R ++ +LQL +H L+M ++ R + ++ E ++ RE +
Sbjct: 287 SSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMR 346
Query: 345 DNLDLDMDQLEKR 357
+ + D+LE+R
Sbjct: 347 EEAERTRDELERR 359
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 83.2 bits (204), Expect = 6e-16
Identities = 79/373 (21%), Positives = 164/373 (43%), Gaps = 37/373 (9%)
Query: 2 NKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSV 61
++++F + + Q + + D + +K L VC L L++ FGL
Sbjct: 7 SRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY 66
Query: 62 IQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRL-ISDRAA 120
+ ++++ +K+ + + SK P+ HF ++Y EN +
Sbjct: 67 TIKDTVAWLKMDKKVLDH-------DVSKE-----EPVTFHFLAKFYPENAEEELVQEIT 114
Query: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180
++ ++ ++KQ+L + EA LLA++A+QA G++ + H + E P V+
Sbjct: 115 QHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVI 174
Query: 181 S--KRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEAS 238
+ + + + I + + EA ++Y+K A L+ V+Y+ + ++K+ E
Sbjct: 175 NLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI-RNKKGTE-- 231
Query: 239 LTLGLTMRGIQIFQNLDEEKQLL--YDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYT 296
L LG+ G+ I+ D E +L FPW + + + K+F I P L + +
Sbjct: 232 LLLGVDALGLHIY---DPENRLTPKISFPWNEIRNISYSDKEFTIKP--LDKKIDVFKFN 286
Query: 297 GCPMR-SRHLLQLLSNSHRLYM-----------NLQPVLRHIRKLEENEEKKQYRESYIS 344
+R ++ +LQL +H L+M ++ R + ++ E ++ RE +
Sbjct: 287 SSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMR 346
Query: 345 DNLDLDMDQLEKR 357
+ + D+LE+R
Sbjct: 347 EEAERTRDELERR 359
>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 83.2 bits (204), Expect = 6e-16
Identities = 79/373 (21%), Positives = 164/373 (43%), Gaps = 37/373 (9%)
Query: 2 NKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSV 61
++++F + + Q + + D + +K L VC L L++ FGL
Sbjct: 7 SRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY 66
Query: 62 IQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRL-ISDRAA 120
+ ++++ +K+ + + SK P+ HF ++Y EN +
Sbjct: 67 TIKDTVAWLKMDKKVLDH-------DVSKE-----EPVTFHFLAKFYPENAEEELVQEIT 114
Query: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180
++ ++ ++KQ+L + EA LLA++A+QA G++ + H + E P V+
Sbjct: 115 QHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVI 174
Query: 181 S--KRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEAS 238
+ + + + I + + EA ++Y+K A L+ V+Y+ + ++K+ E
Sbjct: 175 NLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI-RNKKGTE-- 231
Query: 239 LTLGLTMRGIQIFQNLDEEKQLL--YDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYT 296
L LG+ G+ I+ D E +L FPW + + + K+F I P L + +
Sbjct: 232 LLLGVDALGLHIY---DPENRLTPKISFPWNEIRNISYSDKEFTIKP--LDKKIDVFKFN 286
Query: 297 GCPMR-SRHLLQLLSNSHRLYM-----------NLQPVLRHIRKLEENEEKKQYRESYIS 344
+R ++ +LQL +H L+M ++ R + ++ E ++ RE +
Sbjct: 287 SSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMR 346
Query: 345 DNLDLDMDQLEKR 357
+ + D+LE+R
Sbjct: 347 EEAERTRDELERR 359
>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
Length = 595
Score = 83.2 bits (204), Expect = 6e-16
Identities = 79/373 (21%), Positives = 164/373 (43%), Gaps = 37/373 (9%)
Query: 2 NKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSV 61
++++F + + Q + + D + +K L VC L L++ FGL
Sbjct: 7 SRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY 66
Query: 62 IQNNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRL-ISDRAA 120
+ ++++ +K+ + + SK P+ HF ++Y EN +
Sbjct: 67 TIKDTVAWLKMDKKVLDH-------DVSKE-----EPVTFHFLAKFYPENAEEELVQEIT 114
Query: 121 RYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVV 180
++ ++ ++KQ+L + EA LLA++A+QA G++ + H + E P V+
Sbjct: 115 QHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVI 174
Query: 181 S--KRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEAS 238
+ + + + I + + EA ++Y+K A L+ V+Y+ + ++K+ E
Sbjct: 175 NLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI-RNKKGTE-- 231
Query: 239 LTLGLTMRGIQIFQNLDEEKQLL--YDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYT 296
L LG+ G+ I+ D E +L FPW + + + K+F I P L + +
Sbjct: 232 LLLGVDALGLHIY---DPENRLTPKISFPWNEIRNISYSDKEFTIKP--LDKKIDVFKFN 286
Query: 297 GCPMR-SRHLLQLLSNSHRLYM-----------NLQPVLRHIRKLEENEEKKQYRESYIS 344
+R ++ +LQL +H L+M ++ R + ++ E ++ RE +
Sbjct: 287 SSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMR 346
Query: 345 DNLDLDMDQLEKR 357
+ + D+LE+R
Sbjct: 347 EEAERTRDELERR 359
>gi|150010540 FERM domain containing 4B [Homo sapiens]
Length = 1034
Score = 80.5 bits (197), Expect = 4e-15
Identities = 68/277 (24%), Positives = 128/277 (46%), Gaps = 27/277 (9%)
Query: 12 MQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNN-EHVYM 70
M + R + L +D L +++ K+L +LL V LK+ FG++ I + + ++
Sbjct: 55 MTEGRHCQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWL 114
Query: 71 ELSQKLYKY-CPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLR 129
+L ++ + PK+ P I+HF V++Y+E+ + D+ ++ + +
Sbjct: 115 QLDHRVLDHDLPKK------------PGPTILHFAVRFYIESISFLKDKTTVELFFLNAK 162
Query: 130 KQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRG----- 184
V Q + E F LAAF LQ G++ +++ K + FP+ + +
Sbjct: 163 ACVHKGQIEVESETIFKLAAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYC 222
Query: 185 KDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLT 244
+D +++H + LT +A ++Y+K L VHYY + KDK+ + LG++
Sbjct: 223 EDRVIEHYLKIK----GLTRGQAVVQYMKIVEALPTYGVHYYAV-KDKQGL--PWWLGIS 275
Query: 245 MRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEI 281
+GI + D+ K F W + L F KKF +
Sbjct: 276 YKGIGQYDIQDKVKPRKL-FQWKQLENLYFREKKFAV 311
>gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens]
Length = 548
Score = 77.0 bits (188), Expect = 5e-14
Identities = 64/277 (23%), Positives = 128/277 (46%), Gaps = 25/277 (9%)
Query: 98 PMIIHFRVQYYVENGRL-ISDRAARYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADL 156
P+ HF ++Y EN + ++ ++ ++KQ+L + EA LLA++A+QA
Sbjct: 49 PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKY 108
Query: 157 GNFKRNKHYGKYFEPEAYFPSWVVS--KRGKDYILKHIPNMHKDQFALTASEAHLKYIKE 214
G++ + H + E P V++ + + + I + + EA ++Y+K
Sbjct: 109 GDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKI 168
Query: 215 AVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQLL--YDFPWTNVGKL 272
A L+ V+Y+ + ++K+ E L LG+ G+ I+ D E +L FPW + +
Sbjct: 169 AQDLEMYGVNYFAI-RNKKGTE--LLLGVDALGLHIY---DPENRLTPKISFPWNEIRNI 222
Query: 273 VFVGKKFEILPDGLPSARKLIYYTGCPMR-SRHLLQLLSNSHRLYM-----------NLQ 320
+ K+F I P L + + +R ++ +LQL +H L+M ++
Sbjct: 223 SYSDKEFTIKP--LDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMK 280
Query: 321 PVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKR 357
R + ++ E ++ RE + + + D+LE+R
Sbjct: 281 AQAREEKARKQMERQRLAREKQMREEAERTRDELERR 317
>gi|34328899 protein tyrosine phosphatase, non-receptor type 14
[Homo sapiens]
Length = 1187
Score = 76.6 bits (187), Expect = 6e-14
Identities = 63/298 (21%), Positives = 125/298 (41%), Gaps = 21/298 (7%)
Query: 20 IFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHV-YMELSQKLYK 78
I L + + ++V+ + L V L L++ H FGL + ++ ++EL + L K
Sbjct: 25 IRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKK 84
Query: 79 YCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCV 138
+ +D+F ++ F V +YV N + A RY YY ++K VL +
Sbjct: 85 H------------LDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLR 132
Query: 139 LREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIPNMHKD 198
+ LA A+QAD G++ + E + + + + + + + HK
Sbjct: 133 CTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKA 192
Query: 199 QFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEK 258
+ +EA L YI E RLD ++ K + LG+ GI + + +
Sbjct: 193 HSGILPAEAELMYINEVERLDGFG---QEIFPVKDNHGNCVHLGIFFMGIFVRNRIGRQA 249
Query: 259 QLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLY 316
+ + W ++G + K IL + + +++T ++++ +L + H+ Y
Sbjct: 250 VI---YRWNDMGNITH--NKSTILVELINKEETALFHTDDIENAKYISRLFATRHKFY 302
>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
Length = 570
Score = 76.6 bits (187), Expect = 6e-14
Identities = 104/536 (19%), Positives = 207/536 (38%), Gaps = 69/536 (12%)
Query: 1 MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS 60
+++L ++R ++ S + L +D I L +C L L + FG+
Sbjct: 2 LSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIR 61
Query: 61 VIQ-NNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRA 119
+ + + ++E ++ + K + PP + FRV++Y + + +
Sbjct: 62 FVDPDKQRHWLEFTKSVVKQLRSQ-------------PPFTMCFRVKFYPADPAALKEEI 108
Query: 120 ARYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWV 179
RY + +++ + H + + + LLAA+ LQA++G++ KH PE Y +
Sbjct: 109 TRYLVFLQIKRDLYHGRLLCKTSDAALLAAYILQAEIGDYDSGKH------PEGYSSKFQ 162
Query: 180 VSKRGKDYILKHIPNMHKDQFA-LTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEAS 238
+ + + + I +HK + + T + + L ++++A L+ V + +++ +
Sbjct: 163 FFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRKAQTLETYGVDPHPC----KDVSGN 218
Query: 239 LT-LGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLI-YYT 296
L T G + Q + ++ W V KL F GK F + + ++ Y+
Sbjct: 219 AAFLAFTPFGFVVLQG----NKRVHFIKWNEVTKLKFEGKTFYLYVSQKEEKKIILTYFA 274
Query: 297 GCPMRSRHLLQL-----------LSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYISD 345
P +HL + S+ R + + R K+ ES S
Sbjct: 275 PTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFRYSGRVAKEVMES--SA 332
Query: 346 NLDLDMDQLEKRSRASGSSAGSMKH-KRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSY 404
+ + ++ + S S+ H RLS + H S +E RD+
Sbjct: 333 KIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAVHISIMEGLESLRDSAHSTPV 392
Query: 405 SSSAIHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEES 464
S TSHG + V S D ++ + ++ D E +
Sbjct: 393 RS-------------TSHGDTFLPHVRSSRTD------SNERVAVIAD-----EAYSPAD 428
Query: 465 LEVSPDMCIYITEDMLMSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQ 520
+ + + E ML+SR++NG + I +E S S+ + T V+ G +L Q
Sbjct: 429 SVLPTPVAEHSLELMLLSRQINGATCSIEEEKESEASTPTATEVEALGGELRALCQ 484
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 75.1 bits (183), Expect = 2e-13
Identities = 49/188 (26%), Positives = 96/188 (51%), Gaps = 17/188 (9%)
Query: 96 GPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQAD 155
G P ++FRV+++V + + + RY Y+ +++ +L + LLA+FA+Q++
Sbjct: 98 GSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSE 157
Query: 156 LGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEA 215
LG++ ++++ Y ++ P+ + +D+ K I +H+ L+ +EA Y+ A
Sbjct: 158 LGDYDQSENLSGYLSDYSFIPN-----QPQDF-EKEIAKLHQQHIGLSPAEAEFNYLNTA 211
Query: 216 --VRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLV 273
+ L V HY R D+ E + +G+ GI I++N + + FPW + K+
Sbjct: 212 RTLELYGVEFHYAR---DQSNNE--IMIGVMSGGILIYKN----RVRMNTFPWLKIVKIS 262
Query: 274 FVGKKFEI 281
F K+F I
Sbjct: 263 FKCKQFFI 270
>gi|116063562 FERM domain containing 4A [Homo sapiens]
Length = 1039
Score = 75.1 bits (183), Expect = 2e-13
Identities = 70/325 (21%), Positives = 144/325 (44%), Gaps = 36/325 (11%)
Query: 11 VMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHV-Y 69
+M + R + L +D L +++ K+L +LL V LK+ FG++ H+ +
Sbjct: 15 MMTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNW 74
Query: 70 MELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLR 129
++L +++ ++ ++ K++ P++++F V++Y+E+ + D A ++ + +
Sbjct: 75 LQLDRRVLEH---DFPKKSG--------PVVLYFCVRFYIESISYLKDNATIELFFLNAK 123
Query: 130 KQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRG----- 184
+ + E F LA++ LQ G+F N+ + P+ + +
Sbjct: 124 SCIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYC 183
Query: 185 KDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLT 244
+D +++H +K T +A + Y+ L VHYY + KDK+ I LGL+
Sbjct: 184 EDRVIEH----YKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAV-KDKQGI--PWWLGLS 236
Query: 245 MRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEIL---PDGLPSARKLIYYTG---- 297
+GI + D+ K F W + L F KKF + P R+ ++G
Sbjct: 237 YKGIFQYDYHDKVKPRKI-FQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVH 295
Query: 298 ----CPMRSRHLLQLLSNSHRLYMN 318
CP + + + + H+ Y++
Sbjct: 296 TWYACPALIKSIWAMAISQHQFYLD 320
Score = 30.8 bits (68), Expect = 3.8
Identities = 22/58 (37%), Positives = 27/58 (46%), Gaps = 8/58 (13%)
Query: 376 HSTASHSSSHTSGIEADTK----PRDTGPEDSYS----SSAIHRKLKTCSSMTSHGSS 425
HS A H +S +E+ K DTG D Y+ SS + CSS TSH SS
Sbjct: 699 HSLALHFRHRSSSLESQGKLLGSENDTGSPDFYTPRTRSSNGSDPMDDCSSCTSHSSS 756
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 74.7 bits (182), Expect = 2e-13
Identities = 51/213 (23%), Positives = 100/213 (46%), Gaps = 14/213 (6%)
Query: 69 YMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHL 128
Y + S + Y P + E + I+ GPP ++F +++Y E+ + + RY ++ +
Sbjct: 61 YCDRSHQTYWLDPAKTLAEHKELINT-GPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQV 119
Query: 129 RKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYI 188
++ VL + L A+A+Q++LG++ KH Y + P K+ +
Sbjct: 120 KQDVLQGRLPCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPD------QKEEL 173
Query: 189 LKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGI 248
+ I +HK SEA L Y++ A L+ V + +Y + + + LGLT G+
Sbjct: 174 EEAIERIHKTLMGQIPSEAELNYLRTAKSLEMYGVDLHPVYGENK---SEYFLGLTPVGV 230
Query: 249 QIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEI 281
+++N K+ + + W + K+ F +FE+
Sbjct: 231 VVYKN----KKQVGKYFWPRITKVHFKETQFEL 259
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 71.6 bits (174), Expect = 2e-12
Identities = 50/199 (25%), Positives = 93/199 (46%), Gaps = 18/199 (9%)
Query: 87 EASKGIDQF---GPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCVLREEA 143
EASK I + G P +HFRV++++ + + R+ Y+ L+ + + +
Sbjct: 86 EASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNS 145
Query: 144 YFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIPNMHKDQFALT 203
+LA++A+Q+ G++ + H+ Y + P + +D++ K + ++H+ L
Sbjct: 146 AVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPD-----QNEDFLTK-VESLHEQHSGLK 199
Query: 204 ASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQLLYD 263
SEA YI A LD V L+ + L +G+ G+ +++ K +
Sbjct: 200 QSEAESCYINIARTLDFYGVE---LHSGRDLHNLDLMIGIASAGVAVYR-----KYICTS 251
Query: 264 F-PWTNVGKLVFVGKKFEI 281
F PW N+ K+ F KKF I
Sbjct: 252 FYPWVNILKISFKRKKFFI 270
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 71.6 bits (174), Expect = 2e-12
Identities = 50/199 (25%), Positives = 93/199 (46%), Gaps = 18/199 (9%)
Query: 87 EASKGIDQF---GPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCVLREEA 143
EASK I + G P +HFRV++++ + + R+ Y+ L+ + + +
Sbjct: 86 EASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNS 145
Query: 144 YFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIPNMHKDQFALT 203
+LA++A+Q+ G++ + H+ Y + P + +D++ K + ++H+ L
Sbjct: 146 AVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPD-----QNEDFLTK-VESLHEQHSGLK 199
Query: 204 ASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQLLYD 263
SEA YI A LD V L+ + L +G+ G+ +++ K +
Sbjct: 200 QSEAESCYINIARTLDFYGVE---LHSGRDLHNLDLMIGIASAGVAVYR-----KYICTS 251
Query: 264 F-PWTNVGKLVFVGKKFEI 281
F PW N+ K+ F KKF I
Sbjct: 252 FYPWVNILKISFKRKKFFI 270
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 69.3 bits (168), Expect = 1e-11
Identities = 65/311 (20%), Positives = 127/311 (40%), Gaps = 34/311 (10%)
Query: 1 MNKLNFHNNRV--MQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFG 58
M ++F ++ V + I L +D ++ I + L+ +C+ L + FG
Sbjct: 15 MKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFG 74
Query: 59 LSVIQ-NNEHVYMELSQKLYKYCPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISD 117
+ + + ++E ++ ++K PP + FRV++Y I +
Sbjct: 75 IRYVDPEKQRHWLEPNKSIFKQMKTH-------------PPYTMCFRVKFYPHEPLKIKE 121
Query: 118 RAARYYYYWHLRKQVLHSQ--CVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYF 175
RY Y +++ + H + C + AY L A +QA+LG++ ++H PE Y
Sbjct: 122 ELTRYLLYLQIKRDIFHGRLLCSFSDAAY--LGACIVQAELGDYDPDEH------PENYI 173
Query: 176 PSWVVSKRGKDYILKHIPNMHKDQF-ALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKRE 234
+ + + + + I +HK++ + A + +A L+ V + K
Sbjct: 174 SEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAHTLETYGVDPHPC---KDS 230
Query: 235 IEASLTLGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIY 294
+ LG T G +FQ + ++ W +V KL F GK F ++ L +
Sbjct: 231 TGTTTFLGFTAAGFVVFQG----NKRIHLIKWPDVCKLKFEGKTFYVIGTQKEKKAMLAF 286
Query: 295 YTGCPMRSRHL 305
+T P +HL
Sbjct: 287 HTSTPAACKHL 297
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 68.2 bits (165), Expect = 2e-11
Identities = 56/230 (24%), Positives = 104/230 (45%), Gaps = 16/230 (6%)
Query: 20 IFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELSQKLYKY 79
I L N+E + ++V+ + L V L L++ F L Y + +Q+ +
Sbjct: 27 IQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSL-------WYYNKQNQRRWVD 79
Query: 80 CPKEWKKEASKGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCVL 139
K KK+ +D++ ++F V +YV + + RY YY L+K +L
Sbjct: 80 LEKPLKKQ----LDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPC 135
Query: 140 REEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFP-SWVVSKRGKDYILKHIPNMHKD 198
E LA A+QAD G+F + + + + A FP W+ ++ + + + +H+
Sbjct: 136 TLEQAIQLAGLAVQADFGDFDQYESQ-DFLQKFALFPVGWLQDEKVLEEATQKVALLHQK 194
Query: 199 QFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGI 248
LTA +A + Y++E R+D Y KD + + +++G + GI
Sbjct: 195 YRGLTAPDAEMLYMQEVERMDGYGEESYPA-KDSQ--GSDISIGACLEGI 241
>gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens]
Length = 507
Score = 65.9 bits (159), Expect = 1e-10
Identities = 58/246 (23%), Positives = 114/246 (46%), Gaps = 24/246 (9%)
Query: 128 LRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVS--KRGK 185
++KQ+L + EA LLA++A+QA G++ + H + E P V++ +
Sbjct: 39 VKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTP 98
Query: 186 DYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTM 245
+ + I + + EA ++Y+K A L+ V+Y+ + ++K+ E L LG+
Sbjct: 99 EMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI-RNKKGTE--LLLGVDA 155
Query: 246 RGIQIFQNLDEEKQLL--YDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMR-S 302
G+ I+ D E +L FPW + + + K+F I P L + + +R +
Sbjct: 156 LGLHIY---DPENRLTPKISFPWNEIRNISYSDKEFTIKP--LDKKIDVFKFNSSKLRVN 210
Query: 303 RHLLQLLSNSHRLYM-----------NLQPVLRHIRKLEENEEKKQYRESYISDNLDLDM 351
+ +LQL +H L+M ++ R + ++ E ++ RE + + +
Sbjct: 211 KLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTR 270
Query: 352 DQLEKR 357
D+LE+R
Sbjct: 271 DELERR 276
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,432,397
Number of Sequences: 37866
Number of extensions: 1061331
Number of successful extensions: 4558
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 115
Number of HSP's that attempted gapping in prelim test: 4169
Number of HSP's gapped (non-prelim): 339
length of query: 614
length of database: 18,247,518
effective HSP length: 108
effective length of query: 506
effective length of database: 14,157,990
effective search space: 7163942940
effective search space used: 7163942940
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.