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Search of human proteins with 226693398
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
(521 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 1058 0.0
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 1043 0.0
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 386 e-107
gi|188497642 ARHGAP15 [Homo sapiens] 356 2e-98
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap... 315 5e-86
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap... 315 5e-86
gi|122939151 Rho GTPase activating protein 9 isoform 2 [Homo sap... 235 8e-62
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 146 5e-35
gi|23510413 sorting nexin 26 [Homo sapiens] 141 1e-33
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 139 8e-33
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 139 8e-33
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 139 8e-33
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 138 1e-32
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 138 1e-32
gi|229094128 active breakpoint cluster region-related protein i... 137 2e-32
gi|38679957 active breakpoint cluster region-related protein is... 137 2e-32
gi|38679954 active breakpoint cluster region-related protein is... 137 2e-32
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 136 5e-32
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 132 1e-30
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 132 1e-30
gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens] 132 1e-30
gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens] 126 4e-29
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s... 125 7e-29
gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sap... 123 4e-28
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap... 123 4e-28
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi... 122 6e-28
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 122 8e-28
gi|208022687 GTPase regulator associated with the focal adhesion... 120 2e-27
gi|7662208 GTPase regulator associated with the focal adhesion k... 120 2e-27
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens] 119 9e-27
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 1058 bits (2735), Expect = 0.0
Identities = 521/521 (100%), Positives = 521/521 (100%)
Query: 1 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS 60
MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS
Sbjct: 1 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS 60
Query: 61 QDKQMLYTNHFTQEQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPA 120
QDKQMLYTNHFTQEQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPA
Sbjct: 61 QDKQMLYTNHFTQEQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPA 120
Query: 121 TAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQ 180
TAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQ
Sbjct: 121 TAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQ 180
Query: 181 PSKFSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIA 240
PSKFSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIA
Sbjct: 181 PSKFSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIA 240
Query: 241 QGIQELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVR 300
QGIQELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVR
Sbjct: 241 QGIQELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVR 300
Query: 301 HKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDI 360
HKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDI
Sbjct: 301 HKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDI 360
Query: 361 DGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHF 420
DGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHF
Sbjct: 361 DGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHF 420
Query: 421 RQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAI 480
RQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAI
Sbjct: 421 RQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAI 480
Query: 481 VFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH 521
VFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
Sbjct: 481 VFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH 521
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 1043 bits (2697), Expect = 0.0
Identities = 521/548 (95%), Positives = 521/548 (95%), Gaps = 27/548 (4%)
Query: 1 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS 60
MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS
Sbjct: 1 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS 60
Query: 61 QDKQMLYTNHFTQEQ---------------------------VPVPAPRSIHKSSQDGDT 93
QDKQMLYTNHFTQEQ VPVPAPRSIHKSSQDGDT
Sbjct: 61 QDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDT 120
Query: 94 PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS 153
PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS
Sbjct: 121 PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS 180
Query: 154 ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE 213
ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE
Sbjct: 181 ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE 240
Query: 214 LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQE 273
LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQE
Sbjct: 241 LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQE 300
Query: 274 KEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA 333
KEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA
Sbjct: 301 KEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA 360
Query: 334 LCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW 393
LCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW
Sbjct: 361 LCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW 420
Query: 394 EDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDT 453
EDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDT
Sbjct: 421 EDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDT 480
Query: 454 LRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQ 513
LRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQ
Sbjct: 481 LRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQ 540
Query: 514 CADIFPPH 521
CADIFPPH
Sbjct: 541 CADIFPPH 548
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 386 bits (992), Expect = e-107
Identities = 241/550 (43%), Positives = 327/550 (59%), Gaps = 56/550 (10%)
Query: 9 SPGDPRPPTPETDYPESLTSYPEEDYSPVGS--------FGEPGPTSPLT--TPPGWSCH 58
+PGD + E +Y TSY + D S GS E G T + T W H
Sbjct: 311 NPGDQELLSSEENYYS--TSYSQSD-SQCGSPPRGWSEELDERGHTLYTSDYTNEKWLKH 367
Query: 59 VS-QDKQMLYT-------------NHFTQEQVPVPAPRSIHKSSQDG------------- 91
V Q +Q Y+ N +Q+Q + RS+ + Q+
Sbjct: 368 VDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVL 427
Query: 92 DTPAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKH 151
DT + SP K P + S A K +K G+L+ TK A+ GK++RK +
Sbjct: 428 DTNDKESPTASK-PCFPENESSPSSPKHQDTASSPKDQEKYGLLNVTKIAENGKKVRK-N 485
Query: 152 WSASWTVLEGGVLTFFKD--SKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRK 209
W +SW VL+G L F K S TS G S S PE+TV+L+GAT+ A KDKSS+K
Sbjct: 486 WLSSWAVLQGSSLLFTKTQGSSTSWFG-----SNQSKPEFTVDLKGATIEMASKDKSSKK 540
Query: 210 NVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLG 269
NV EL++R G+E LIQ D++ +I+ W K ++ I + E E E D E+
Sbjct: 541 NVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETD-EGIEEEIPDSPGIEK-- 597
Query: 270 SWQEKEEDARPNAAAPALGPVGLES-DLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFG 328
+KE++ + + ++S + K + L+KFL RRPTLQ++REKGYIKDQVFG
Sbjct: 598 --HDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFG 655
Query: 329 CALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDL 388
LA LC+RE VP+FV+ CI VE GLDIDG+YR+SGNLA IQKLR+ V+HDE+LDL
Sbjct: 656 SNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDL 715
Query: 389 DDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPA 448
+D +WED+HVITGALK+FFRELPEPLF F+HF F+ AIK Q+ +R V+DL+R LP
Sbjct: 716 NDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIK-QEPRQRVAAVKDLIRQLPK 774
Query: 449 PNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVE 508
PN DT+++LF+HL RVIE+GE+NRM+ QS+AIVFGPTLL+PE E ++ + V+QNQ+VE
Sbjct: 775 PNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVE 834
Query: 509 LILQQCADIF 518
LIL + + IF
Sbjct: 835 LILLELSSIF 844
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 356 bits (914), Expect = 2e-98
Identities = 191/397 (48%), Positives = 264/397 (66%), Gaps = 13/397 (3%)
Query: 129 LDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPE 188
++K G L + K AD GK+LRK +WS SW VL + F+K+SK A ++ K PE
Sbjct: 80 VEKEGYLQKAKIADGGKKLRK-NWSTSWIVLSSRRIEFYKESKQQALSNMKTGHK---PE 135
Query: 189 YTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQEL-- 246
+V+L GA + WA K+KSSRKNV ++ + G+E+L+Q D + II W AI I L
Sbjct: 136 -SVDLCGAHIEWA-KEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPK 193
Query: 247 SAELPPEESESSRVDFGSSERLGSW-----QEKEEDARPNAAAPALGPVGLESDLSKVRH 301
+ P E ++ SS L S +E++ + R + SD ++V+
Sbjct: 194 DSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKS 253
Query: 302 KLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDID 361
+L+KF+ RRP+L++L+EKG IKDQ+FG L +CERE S VP FV+QCI AVE RGLD+D
Sbjct: 254 RLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVD 313
Query: 362 GLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFR 421
G+YR+SGNLATIQKLR+ V+ +E+L+LDD +WED+HV+TGALK+FFRELPEPLFP+S F
Sbjct: 314 GIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFE 373
Query: 422 QFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIV 481
QF+ AIK QD R V+ LV+ LP PN DT+++LF HL +++ +N MS QS+ IV
Sbjct: 374 QFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIV 433
Query: 482 FGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 518
FGPTLLR E E +M + MV+QNQ+ EL+L + + IF
Sbjct: 434 FGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIF 470
>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
sapiens]
Length = 731
Score = 315 bits (808), Expect = 5e-86
Identities = 177/419 (42%), Positives = 252/419 (60%), Gaps = 38/419 (9%)
Query: 129 LDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPE 188
++K+G+L+ TK A G++LRK +W SW VL G L F+++ +A P+ S PE
Sbjct: 323 VEKSGLLNMTKIAQGGRKLRK-NWGPSWVVLTGNSLVFYREPPPTAPSSGWGPAG-SRPE 380
Query: 189 YTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSA 248
+V+LRGA L+ + SSR+NVL +R+ G E+L+Q D E + WH+A+ I+ L
Sbjct: 381 SSVDLRGAALAHG-RHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLDR 439
Query: 249 ELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPAL----------GPVGLESDLSK 298
E P E S GS S E EE+ + P L GP G E + +
Sbjct: 440 ENPLELRLS-----GSGPAELSAGEDEEEESELVSKPLLRLSSRRSSIRGPEGTEQN--R 492
Query: 299 VRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGL 358
VR+KL++ + +RP LQSL+E+G ++DQVFGC L +LC+RE VP F++ CI AV+ RGL
Sbjct: 493 VRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGL 552
Query: 359 DIDGLYRISGNLATIQKLRYKVDHDE------------------RLDLDDGRWEDVHVIT 400
D+DG+YR+SGNLA +QKLR+ VD + RLDLD W+D+HV+T
Sbjct: 553 DVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVT 612
Query: 401 GALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQH 460
GALKLF RELP+PL P F AA+ L + + +++L+ S+P PNHDTLR L +H
Sbjct: 613 GALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEH 672
Query: 461 LCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFP 519
LCRVI H ++NRM+ ++ IVFGPTL RPE E + ++ Q+V+L+L +FP
Sbjct: 673 LCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQLVQLMLTNFTSLFP 731
>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
sapiens]
Length = 547
Score = 315 bits (808), Expect = 5e-86
Identities = 177/419 (42%), Positives = 252/419 (60%), Gaps = 38/419 (9%)
Query: 129 LDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPE 188
++K+G+L+ TK A G++LRK +W SW VL G L F+++ +A P+ S PE
Sbjct: 139 VEKSGLLNMTKIAQGGRKLRK-NWGPSWVVLTGNSLVFYREPPPTAPSSGWGPAG-SRPE 196
Query: 189 YTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSA 248
+V+LRGA L+ + SSR+NVL +R+ G E+L+Q D E + WH+A+ I+ L
Sbjct: 197 SSVDLRGAALAHG-RHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLDR 255
Query: 249 ELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPAL----------GPVGLESDLSK 298
E P E S GS S E EE+ + P L GP G E + +
Sbjct: 256 ENPLELRLS-----GSGPAELSAGEDEEEESELVSKPLLRLSSRRSSIRGPEGTEQN--R 308
Query: 299 VRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGL 358
VR+KL++ + +RP LQSL+E+G ++DQVFGC L +LC+RE VP F++ CI AV+ RGL
Sbjct: 309 VRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGL 368
Query: 359 DIDGLYRISGNLATIQKLRYKVDHDE------------------RLDLDDGRWEDVHVIT 400
D+DG+YR+SGNLA +QKLR+ VD + RLDLD W+D+HV+T
Sbjct: 369 DVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVT 428
Query: 401 GALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQH 460
GALKLF RELP+PL P F AA+ L + + +++L+ S+P PNHDTLR L +H
Sbjct: 429 GALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEH 488
Query: 461 LCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFP 519
LCRVI H ++NRM+ ++ IVFGPTL RPE E + ++ Q+V+L+L +FP
Sbjct: 489 LCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQLVQLMLTNFTSLFP 547
>gi|122939151 Rho GTPase activating protein 9 isoform 2 [Homo
sapiens]
Length = 640
Score = 235 bits (599), Expect = 8e-62
Identities = 138/324 (42%), Positives = 192/324 (59%), Gaps = 41/324 (12%)
Query: 129 LDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPE 188
++K+G+L+ TK A G++LRK +W SW VL G L F+++ +A P+ S PE
Sbjct: 323 VEKSGLLNMTKIAQGGRKLRK-NWGPSWVVLTGNSLVFYREPPPTAPSSGWGPAG-SRPE 380
Query: 189 YTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSA 248
+V+LRGA L+ + SSR+NVL +R+ G E+L+Q D E + WH+A+ I+ L
Sbjct: 381 SSVDLRGAALAHG-RHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLDR 439
Query: 249 ELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPAL----------GPVGLESDLSK 298
E P E S GS S E EE+ + P L GP G E + +
Sbjct: 440 ENPLELRLS-----GSGPAELSAGEDEEEESELVSKPLLRLSSRRSSIRGPEGTEQN--R 492
Query: 299 VRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGL 358
VR+KL++ + +RP LQSL+E+G ++DQVFGC L +LC+RE VP F++ CI AV+ RGL
Sbjct: 493 VRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGL 552
Query: 359 DIDGLYRISGNLATIQKLRYKVDHDE------------------RLDLDDGRWEDVHVIT 400
D+DG+YR+SGNLA +QKLR+ VD + RLDLD W+D+HV+T
Sbjct: 553 DVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVT 612
Query: 401 GALKLFFRELPEPLFP---FSHFR 421
GALKLF RELP+PL P HFR
Sbjct: 613 GALKLFLRELPQPLVPPLLLPHFR 636
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 146 bits (368), Expect = 5e-35
Identities = 122/462 (26%), Positives = 214/462 (46%), Gaps = 42/462 (9%)
Query: 78 VPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHR 137
+P+ R + DG + + + P++ S ++S AT + + + + ++
Sbjct: 551 IPSLRMLRSFFTDGSLDSWGTSEDADAPSKRH---STSDLSDATFSDIRR---EGWLYYK 604
Query: 138 TKTADKGKRLRK--KHWSASWTVLEGGVLTFFKDSKT---SAAGGLRQPSKFSTPEYTVE 192
KGK+ + W + L L+ K+ + +AAG + E
Sbjct: 605 QILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGA--GEDEAAPV 662
Query: 193 LRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPP 252
G+ L ++ R++V L + D EYL Q + + W +AI + + + P
Sbjct: 663 CIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGED--P 720
Query: 253 EESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGL---ESDLSKVRHKLRKFLQR 309
+ + + S++L +++ + P A + G GL +S+ K Q
Sbjct: 721 GCANQALI----SKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQD 776
Query: 310 RPT---------------LQSLREKGYIKDQVFGCALAALCE--RERSRVPRFVQQCIRA 352
P + +++ + FG L C+ E RVP V C R
Sbjct: 777 LPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEE-CQPATENQRVPLIVAACCRI 835
Query: 353 VEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGRWEDVHVITGALKLFFRELP 411
VEARGL+ G+YR+ GN A + L+ +++ ++L D RW+D++VI+ LK FFR+LP
Sbjct: 836 VEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLP 895
Query: 412 EPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQN 471
EPLF + FI A +++D R R +R L+R LP ++TL+ L HL + +H E+N
Sbjct: 896 EPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKN 955
Query: 472 RMSVQSVAIVFGPTLLR-PEVEETSMPMTMVFQNQVVELILQ 512
+M +++A+VFGPTL+R E T M M + ++VE ++Q
Sbjct: 956 KMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQ 997
>gi|23510413 sorting nexin 26 [Homo sapiens]
Length = 1126
Score = 141 bits (356), Expect = 1e-33
Identities = 107/358 (29%), Positives = 168/358 (46%), Gaps = 41/358 (11%)
Query: 195 GATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAE----- 249
G L+W D R+ +L E + + A + AQ ELS E
Sbjct: 160 GPVLTWMELDNHGRRLLLS------EEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIV 213
Query: 250 ----LPPEESES-------SRVDFGSSE-------RLGSWQEKEEDARPNAAAPALGPVG 291
+PP E S +V F SE R G + + D P G
Sbjct: 214 SVIDMPPTEDRSWWRGKRGFQVGFFPSECVELFTERPGPGLKADADGPPCGIPAPQGISS 273
Query: 292 LESDLSKVRHKL----RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQ 347
L S + + R KL R F++ RP+ Q LR++G ++ +VFGC L VP+ ++
Sbjct: 274 LTSAVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLR 333
Query: 348 QCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW-EDVHVITGALKLF 406
C +EA G+ +DG+YR+SG + IQ+LR++ D + +L + +D+H ++ KL+
Sbjct: 334 CCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLY 392
Query: 407 FRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIE 466
FRELP PL + + +F A+ + + R V D+++ LP P++ TL L +HL R+
Sbjct: 393 FRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMAR 452
Query: 467 HGEQNRMSVQSVAIVFGPTLLRP-EVEETSMPMTMVF-----QNQVVELILQQCADIF 518
H M +++AIV+ P LLR E+E M F Q+ VVE +L +F
Sbjct: 453 HSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLF 510
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 139 bits (349), Expect = 8e-33
Identities = 71/190 (37%), Positives = 119/190 (62%), Gaps = 2/190 (1%)
Query: 325 QVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHD- 383
+V+ C L L + ++ P V CIR +E+RGL+ +GLYR+SG I+ ++ D D
Sbjct: 264 KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDG 323
Query: 384 ERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLV 443
E+ D+ +ED+++ITGALKL+FR+LP PL + + +FI + K+ D + + + +
Sbjct: 324 EKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 383
Query: 444 RSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEVEETSMPMTMVF 502
+ LP + +TLR L HL RV H ++N M+ +++ IVFGPTL+R PE++ + + +
Sbjct: 384 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRY 443
Query: 503 QNQVVELILQ 512
Q VVEL+++
Sbjct: 444 QRLVVELLIK 453
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 139 bits (349), Expect = 8e-33
Identities = 71/190 (37%), Positives = 119/190 (62%), Gaps = 2/190 (1%)
Query: 325 QVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHD- 383
+V+ C L L + ++ P V CIR +E+RGL+ +GLYR+SG I+ ++ D D
Sbjct: 238 KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDG 297
Query: 384 ERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLV 443
E+ D+ +ED+++ITGALKL+FR+LP PL + + +FI + K+ D + + + +
Sbjct: 298 EKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 357
Query: 444 RSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEVEETSMPMTMVF 502
+ LP + +TLR L HL RV H ++N M+ +++ IVFGPTL+R PE++ + + +
Sbjct: 358 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRY 417
Query: 503 QNQVVELILQ 512
Q VVEL+++
Sbjct: 418 QRLVVELLIK 427
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 139 bits (349), Expect = 8e-33
Identities = 121/411 (29%), Positives = 185/411 (45%), Gaps = 40/411 (9%)
Query: 131 KAGVLH-RTKTADKGKRLRK--KHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTP 187
K G LH R DKGKR+ + W + VL G L +KD + PS+ P
Sbjct: 934 KEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTT-----PSEEEQP 988
Query: 188 EYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQG--IQE 245
A L ++ RKNV L + D E L Q + + W K I + + E
Sbjct: 989 ISV----NACLIDISYSETKRKNVFRLTTSD-CECLFQAEDRDDMLAWIKTIQESSNLNE 1043
Query: 246 LSAELPPEESESSRVD-----FGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVR 300
+ + S R+ +E+L + R P +S S
Sbjct: 1044 EDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLSIRQTLLGAKSEPK-TQSPHSPKE 1102
Query: 301 HKLRKFLQRRPT------------LQSLREKGYIKDQV----FGCALAALCERERSR-VP 343
RK L + T + S+ K + K FG L +R +P
Sbjct: 1103 ESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDCPPAHTNRYIP 1162
Query: 344 RFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGRWEDVHVITGA 402
V C + VE RGL+ G+YR+ GN A I ++ +++ +D+ D +W D++VI+
Sbjct: 1163 LIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSL 1222
Query: 403 LKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLC 462
LK FFR+LPEPLF + FI A + +D R + ++ L+ LP +++TL+ L HL
Sbjct: 1223 LKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLK 1282
Query: 463 RVIEHGEQNRMSVQSVAIVFGPTLLR-PEVEETSMPMTMVFQNQVVELILQ 512
V E+ E+N+M +++AIVFGPTL+R E T M M Q ++VE ++Q
Sbjct: 1283 TVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQ 1333
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 138 bits (347), Expect = 1e-32
Identities = 85/208 (40%), Positives = 121/208 (58%), Gaps = 10/208 (4%)
Query: 291 GLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCI 350
G+E LS V+ R+F +R + S ++ G VFG +A + +RERS+VP V+QC+
Sbjct: 980 GIEVKLS-VKFNSREFSLKR--MPSRKQTG-----VFGVKIAVVTKRERSKVPYIVRQCV 1031
Query: 351 RAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWE-DVHVITGALKLFFRE 409
+E RG++ G+YR+SG IQ L+ D + + D+ E DV+ I G LKL+FRE
Sbjct: 1032 EEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK-DVSVMMSEMDVNAIAGTLKLYFRE 1090
Query: 410 LPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGE 469
LPEPLF + F I L D + C+ +L+ SLP N T L HL RV E
Sbjct: 1091 LPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEA 1150
Query: 470 QNRMSVQSVAIVFGPTLLRPEVEETSMP 497
N+MS+ ++A VFGPTLLRP +E+ +P
Sbjct: 1151 VNKMSLHNLATVFGPTLLRPSEKESKLP 1178
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 138 bits (347), Expect = 1e-32
Identities = 85/208 (40%), Positives = 121/208 (58%), Gaps = 10/208 (4%)
Query: 291 GLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCI 350
G+E LS V+ R+F +R + S ++ G VFG +A + +RERS+VP V+QC+
Sbjct: 1024 GIEVKLS-VKFNSREFSLKR--MPSRKQTG-----VFGVKIAVVTKRERSKVPYIVRQCV 1075
Query: 351 RAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWE-DVHVITGALKLFFRE 409
+E RG++ G+YR+SG IQ L+ D + + D+ E DV+ I G LKL+FRE
Sbjct: 1076 EEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK-DVSVMMSEMDVNAIAGTLKLYFRE 1134
Query: 410 LPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGE 469
LPEPLF + F I L D + C+ +L+ SLP N T L HL RV E
Sbjct: 1135 LPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEA 1194
Query: 470 QNRMSVQSVAIVFGPTLLRPEVEETSMP 497
N+MS+ ++A VFGPTLLRP +E+ +P
Sbjct: 1195 VNKMSLHNLATVFGPTLLRPSEKESKLP 1222
>gi|229094128 active breakpoint cluster region-related protein
isoform c [Homo sapiens]
Length = 813
Score = 137 bits (346), Expect = 2e-32
Identities = 83/198 (41%), Positives = 114/198 (57%), Gaps = 8/198 (4%)
Query: 305 KFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLY 364
KF R +L+ K + VFG ++ + +RERS+VP V+QC+ VE RG++ G+Y
Sbjct: 579 KFTSRDMSLKRTPSKK--QTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIY 636
Query: 365 RISGNLATIQKLRYKVDHDER---LDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFR 421
RISG IQ L+ D + + L L D D++ I G LKL+FRELPEPL +
Sbjct: 637 RISGVATDIQALKAVFDANNKDILLMLSD---MDINAIAGTLKLYFRELPEPLLTDRLYP 693
Query: 422 QFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIV 481
F+ I L D A + C+ L+RSLP PN T L +HL RV E N+MS+ ++A V
Sbjct: 694 AFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATV 753
Query: 482 FGPTLLRPEVEETSMPMT 499
FGPTLLRP E+ +T
Sbjct: 754 FGPTLLRPSEVESKAHLT 771
>gi|38679957 active breakpoint cluster region-related protein
isoform a [Homo sapiens]
Length = 859
Score = 137 bits (346), Expect = 2e-32
Identities = 83/198 (41%), Positives = 114/198 (57%), Gaps = 8/198 (4%)
Query: 305 KFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLY 364
KF R +L+ K + VFG ++ + +RERS+VP V+QC+ VE RG++ G+Y
Sbjct: 625 KFTSRDMSLKRTPSKK--QTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIY 682
Query: 365 RISGNLATIQKLRYKVDHDER---LDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFR 421
RISG IQ L+ D + + L L D D++ I G LKL+FRELPEPL +
Sbjct: 683 RISGVATDIQALKAVFDANNKDILLMLSD---MDINAIAGTLKLYFRELPEPLLTDRLYP 739
Query: 422 QFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIV 481
F+ I L D A + C+ L+RSLP PN T L +HL RV E N+MS+ ++A V
Sbjct: 740 AFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATV 799
Query: 482 FGPTLLRPEVEETSMPMT 499
FGPTLLRP E+ +T
Sbjct: 800 FGPTLLRPSEVESKAHLT 817
>gi|38679954 active breakpoint cluster region-related protein
isoform b [Homo sapiens]
Length = 822
Score = 137 bits (346), Expect = 2e-32
Identities = 83/198 (41%), Positives = 114/198 (57%), Gaps = 8/198 (4%)
Query: 305 KFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLY 364
KF R +L+ K + VFG ++ + +RERS+VP V+QC+ VE RG++ G+Y
Sbjct: 588 KFTSRDMSLKRTPSKK--QTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIY 645
Query: 365 RISGNLATIQKLRYKVDHDER---LDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFR 421
RISG IQ L+ D + + L L D D++ I G LKL+FRELPEPL +
Sbjct: 646 RISGVATDIQALKAVFDANNKDILLMLSD---MDINAIAGTLKLYFRELPEPLLTDRLYP 702
Query: 422 QFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIV 481
F+ I L D A + C+ L+RSLP PN T L +HL RV E N+MS+ ++A V
Sbjct: 703 AFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATV 762
Query: 482 FGPTLLRPEVEETSMPMT 499
FGPTLLRP E+ +T
Sbjct: 763 FGPTLLRPSEVESKAHLT 780
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 136 bits (342), Expect = 5e-32
Identities = 77/262 (29%), Positives = 141/262 (53%), Gaps = 9/262 (3%)
Query: 263 GSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQR-----RPTLQSLR 317
GS + LG ++KEED + E+D R + + L+R +P +
Sbjct: 1178 GSDDELGPIRKKEEDQASQGYKGDNAVIPYETDEDPRRRNILRSLRRNTKKPKPKPRPSI 1237
Query: 318 EKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLR 377
K + FG L + E+ +P F+++CI +EA GL +G+YR+SGN + ++ L+
Sbjct: 1238 TKATWESNYFGVPLTTVVTPEKP-IPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQ 1296
Query: 378 YKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSR 437
+ D D LDL + + V+ + GA+K FF ELP+PL P++ + A K+ D+ ++
Sbjct: 1297 RQFDQDHNLDLAEKDFT-VNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLH 1355
Query: 438 CVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEE-TSM 496
++++++ P NH+ + + HL +V + + N M+ ++++I F PTL+RP+ ++
Sbjct: 1356 ALKEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRPDFSTMDAL 1415
Query: 497 PMTMVFQNQVVELILQQCADIF 518
T +Q ++EL +QQC F
Sbjct: 1416 TATRTYQT-IIELFIQQCPFFF 1436
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 132 bits (331), Expect = 1e-30
Identities = 68/190 (35%), Positives = 116/190 (61%), Gaps = 2/190 (1%)
Query: 325 QVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHD- 383
+V+ C L L + ++ P V CIR +EARGL +GLYR+SG I+ ++ D D
Sbjct: 273 KVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDG 332
Query: 384 ERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLV 443
E+ D+ + D+++ITGALKL+FR+LP P+ + + +FI A K+ + R V +++
Sbjct: 333 EKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVL 392
Query: 444 RSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPM-TMVF 502
LP +++TLR L HL +V + + N M+ +++ IVFGPTL+RP + T + M +
Sbjct: 393 MLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRY 452
Query: 503 QNQVVELILQ 512
Q +V+++++
Sbjct: 453 QKLIVQILIE 462
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 132 bits (331), Expect = 1e-30
Identities = 68/190 (35%), Positives = 116/190 (61%), Gaps = 2/190 (1%)
Query: 325 QVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHD- 383
+V+ C L L + ++ P V CIR +EARGL +GLYR+SG I+ ++ D D
Sbjct: 137 KVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDG 196
Query: 384 ERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLV 443
E+ D+ + D+++ITGALKL+FR+LP P+ + + +FI A K+ + R V +++
Sbjct: 197 EKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVL 256
Query: 444 RSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPM-TMVF 502
LP +++TLR L HL +V + + N M+ +++ IVFGPTL+RP + T + M +
Sbjct: 257 MLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRY 316
Query: 503 QNQVVELILQ 512
Q +V+++++
Sbjct: 317 QKLIVQILIE 326
>gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]
Length = 2087
Score = 132 bits (331), Expect = 1e-30
Identities = 75/223 (33%), Positives = 123/223 (55%), Gaps = 8/223 (3%)
Query: 303 LRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDG 362
LR F++ RPT Q L+++G +K++VFGC L VP+ +Q C +E G+ +DG
Sbjct: 346 LRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDG 404
Query: 363 LYRISGNLATIQKLRYKVDHDERLDLDDGRW-EDVHVITGALKLFFRELPEPLFPFSHFR 421
+YR+SG + IQ+LR++ D + DL + +D+H + KL+FRELP PL + +
Sbjct: 405 IYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYE 464
Query: 422 QFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIV 481
+F A+ R + D+++ LP P++ TL L +HL + ++ M +++AIV
Sbjct: 465 KFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIV 524
Query: 482 FGPTLLRPEVEE------TSMPMTMVFQNQVVELILQQCADIF 518
+ P LLR + E T+ M + Q+ VVE IL +F
Sbjct: 525 WAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLF 567
>gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens]
Length = 1738
Score = 126 bits (317), Expect = 4e-29
Identities = 72/219 (32%), Positives = 120/219 (54%), Gaps = 8/219 (3%)
Query: 307 LQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRI 366
++ RPT Q L+++G +K++VFGC L VP+ +Q C +E G+ +DG+YR+
Sbjct: 1 MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDGIYRL 59
Query: 367 SGNLATIQKLRYKVDHDERLDLDDGRW-EDVHVITGALKLFFRELPEPLFPFSHFRQFIA 425
SG + IQ+LR++ D + DL + +D+H + KL+FRELP PL + + +F
Sbjct: 60 SGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSD 119
Query: 426 AIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPT 485
A+ R + D+++ LP P++ TL L +HL + ++ M +++AIV+ P
Sbjct: 120 AVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPN 179
Query: 486 LLRPEVEE------TSMPMTMVFQNQVVELILQQCADIF 518
LLR + E T+ M + Q+ VVE IL +F
Sbjct: 180 LLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLF 218
>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
sapiens]
Length = 874
Score = 125 bits (315), Expect = 7e-29
Identities = 70/177 (39%), Positives = 103/177 (58%), Gaps = 4/177 (2%)
Query: 345 FVQQCIRAVEARGLDIDGLYRISGNLATIQKLR---YKVDHDERLDLDDGRWEDVHVITG 401
FV++CI+AVE RG+ I GLYRI G + +QKL + +D+D W++ IT
Sbjct: 397 FVRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDN-KTITS 455
Query: 402 ALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHL 461
LK + R L EPL + + FI A+K DQ R V LV LP N + L +L +HL
Sbjct: 456 GLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHL 515
Query: 462 CRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 518
+V H +QN M+V ++ ++FGPTL+R + E + M + FQN VVE++++ IF
Sbjct: 516 VKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMMNIKFQNIVVEILIEHYEKIF 572
>gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo
sapiens]
Length = 890
Score = 123 bits (309), Expect = 4e-28
Identities = 72/212 (33%), Positives = 117/212 (55%), Gaps = 8/212 (3%)
Query: 314 QSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATI 373
Q ++KG K++VFGC L + VP+ ++ C VE G+ +DG+YR+SG + I
Sbjct: 5 QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNI 63
Query: 374 QKLRYKVDHDERLDLD-DGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQ 432
QKLR + + + + DL D +D+H ++ K +FRELP+PL + + +F A+ +Q +
Sbjct: 64 QKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLE 123
Query: 433 ARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEV 491
R + +++R LP PN+ TL L +HL + Q M +++AIV+ P LLR ++
Sbjct: 124 PERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDI 183
Query: 492 EETSMPMTMVF-----QNQVVELILQQCADIF 518
E + T F Q+ VVE IL +F
Sbjct: 184 EASGFNGTAAFMEVRVQSIVVEFILTHVDQLF 215
>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
sapiens]
Length = 1101
Score = 123 bits (309), Expect = 4e-28
Identities = 72/212 (33%), Positives = 117/212 (55%), Gaps = 8/212 (3%)
Query: 314 QSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATI 373
Q ++KG K++VFGC L + VP+ ++ C VE G+ +DG+YR+SG + I
Sbjct: 5 QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNI 63
Query: 374 QKLRYKVDHDERLDLD-DGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQ 432
QKLR + + + + DL D +D+H ++ K +FRELP+PL + + +F A+ +Q +
Sbjct: 64 QKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLE 123
Query: 433 ARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEV 491
R + +++R LP PN+ TL L +HL + Q M +++AIV+ P LLR ++
Sbjct: 124 PERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDI 183
Query: 492 EETSMPMTMVF-----QNQVVELILQQCADIF 518
E + T F Q+ VVE IL +F
Sbjct: 184 EASGFNGTAAFMEVRVQSIVVEFILTHVDQLF 215
>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
Length = 1501
Score = 122 bits (307), Expect = 6e-28
Identities = 69/227 (30%), Positives = 118/227 (51%), Gaps = 3/227 (1%)
Query: 293 ESDLSKVRHKLRKFLQRRPTLQ-SLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIR 351
+ + K HK+++ +++ T + + + FG L L E+ +P FV++C+
Sbjct: 1224 DKKMKKKTHKVKEDKKKKKTKNFNPPTRRNWESNYFGMPLQDLVTAEKP-IPLFVEKCVE 1282
Query: 352 AVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELP 411
+E GL +GLYR+SGN ++ + D D ++L V+ + GALK FF +LP
Sbjct: 1283 FIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSME-VTVNAVAGALKAFFADLP 1341
Query: 412 EPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQN 471
+PL P+S + + A K+ D+ R ++++V+ N+D R + HL RV + + N
Sbjct: 1342 DPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHKIN 1401
Query: 472 RMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 518
M+ +++I F PTL+RP+ E T VVE +QQC F
Sbjct: 1402 LMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFFF 1448
>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
Length = 1502
Score = 122 bits (306), Expect = 8e-28
Identities = 68/228 (29%), Positives = 118/228 (51%), Gaps = 4/228 (1%)
Query: 293 ESDLSKVRHKLRKFLQRRPTLQSLRE--KGYIKDQVFGCALAALCERERSRVPRFVQQCI 350
+ + K HK+++ +++ ++ + + FG L L E+ +P FV++C+
Sbjct: 1224 DKKMKKKTHKVKEDKKQKKKTKNFNPPTRRNWESNYFGMPLQDLVTAEKP-IPLFVEKCV 1282
Query: 351 RAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFREL 410
+E GL +GLYR+SGN ++ + D D ++L V+ + GALK FF +L
Sbjct: 1283 EFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSME-VTVNAVAGALKAFFADL 1341
Query: 411 PEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQ 470
P+PL P+S + + A K+ D+ R ++++V+ N+D R + HL RV + +
Sbjct: 1342 PDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHKI 1401
Query: 471 NRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 518
N M+ +++I F PTL+RP+ E T VVE +QQC F
Sbjct: 1402 NLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFFF 1449
>gi|208022687 GTPase regulator associated with the focal adhesion
kinase pp125 isoform b [Homo sapiens]
Length = 759
Score = 120 bits (302), Expect = 2e-27
Identities = 70/178 (39%), Positives = 101/178 (56%), Gaps = 7/178 (3%)
Query: 346 VQQCIRAVEARGLDIDGLYRISGNLATIQKLRY-----KVDHDERLDLDDGRWEDVHVIT 400
+++CI AVE RG++ GLYRI G + +QKL K + D+ WE + IT
Sbjct: 393 IRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDIC-AEWE-IKTIT 450
Query: 401 GALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQH 460
ALK + R LP PL + R FI A KL++Q R + LV LP N L++L H
Sbjct: 451 SALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNH 510
Query: 461 LCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 518
L V + +QN M+V ++ +VFGPTLLRP+ E + M + FQN V+E++++ IF
Sbjct: 511 LANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIF 568
>gi|7662208 GTPase regulator associated with the focal adhesion
kinase pp125 isoform a [Homo sapiens]
Length = 814
Score = 120 bits (302), Expect = 2e-27
Identities = 70/178 (39%), Positives = 101/178 (56%), Gaps = 7/178 (3%)
Query: 346 VQQCIRAVEARGLDIDGLYRISGNLATIQKLRY-----KVDHDERLDLDDGRWEDVHVIT 400
+++CI AVE RG++ GLYRI G + +QKL K + D+ WE + IT
Sbjct: 393 IRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDIC-AEWE-IKTIT 450
Query: 401 GALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQH 460
ALK + R LP PL + R FI A KL++Q R + LV LP N L++L H
Sbjct: 451 SALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNH 510
Query: 461 LCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 518
L V + +QN M+V ++ +VFGPTLLRP+ E + M + FQN V+E++++ IF
Sbjct: 511 LANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIF 568
>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
Length = 786
Score = 119 bits (297), Expect = 9e-27
Identities = 68/180 (37%), Positives = 100/180 (55%), Gaps = 5/180 (2%)
Query: 346 VQQCIRAVEARGLDIDGLYRISGNLATIQKLR---YKVDHDERLDLDDGRWEDVHVITGA 402
+++CI AVE RG++ GLYR+ G + +Q+L V +DL++ +V IT A
Sbjct: 399 IRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSA 458
Query: 403 LKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLC 462
LK + R LPEPL + FI K R + LV LP N + L +L +HL
Sbjct: 459 LKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLT 518
Query: 463 RVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF--PP 520
V H +QN M+V ++ +VFGPTL+RP+ E + M + FQN VVE++++ IF PP
Sbjct: 519 NVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPP 578
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,597,997
Number of Sequences: 37866
Number of extensions: 1280056
Number of successful extensions: 7651
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 132
Number of HSP's successfully gapped in prelim test: 249
Number of HSP's that attempted gapping in prelim test: 6319
Number of HSP's gapped (non-prelim): 1365
length of query: 521
length of database: 18,247,518
effective HSP length: 107
effective length of query: 414
effective length of database: 14,195,856
effective search space: 5877084384
effective search space used: 5877084384
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.