Search of human proteins with 226442878

Search of human proteins with 226442878

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|226442878 ADAMTS-like 5 [Homo sapiens]
         (471 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|226442878 ADAMTS-like 5 [Homo sapiens]                            1023   0.0  
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot...   210   2e-54
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s...   209   3e-54
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s...   209   3e-54
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo...   206   4e-53
gi|145309328 papilin [Homo sapiens]                                   198   1e-50
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot...   191   2e-48
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot...   185   7e-47
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa...   184   1e-46
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot...   182   7e-46
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot...   171   1e-42
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]                   171   2e-42
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]                    171   2e-42
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo...   169   5e-42
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo...   165   9e-41
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t...   159   5e-39
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo...   159   7e-39
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot...   157   3e-38
gi|124430557 a disintegrin-like and metalloprotease with thrombo...   155   1e-37
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo...   152   8e-37
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo...   143   3e-34
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot...   143   4e-34
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]         138   9e-33
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]         138   9e-33
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]                   137   3e-32
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo...   132   5e-31
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot...   125   6e-29
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot...   119   8e-27
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo...   119   8e-27
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot...   115   9e-26

>gi|226442878 ADAMTS-like 5 [Homo sapiens]
          Length = 471

 Score = 1023 bits (2645), Expect = 0.0
 Identities = 471/471 (100%), Positives = 471/471 (100%)

Query: 1   MDSAPLFPRPHLFQNLLLFLWALLNCGLGVSAQGPGEWTPWVSWTRCSSSCGRGVSVRSR 60
           MDSAPLFPRPHLFQNLLLFLWALLNCGLGVSAQGPGEWTPWVSWTRCSSSCGRGVSVRSR
Sbjct: 1   MDSAPLFPRPHLFQNLLLFLWALLNCGLGVSAQGPGEWTPWVSWTRCSSSCGRGVSVRSR 60

Query: 61  RCLRLPGEEPCWGDSHEYRLCQLPDCPPGAVPFRDLQCALYNGRPVLGTQKTYQWVPFHG 120
           RCLRLPGEEPCWGDSHEYRLCQLPDCPPGAVPFRDLQCALYNGRPVLGTQKTYQWVPFHG
Sbjct: 61  RCLRLPGEEPCWGDSHEYRLCQLPDCPPGAVPFRDLQCALYNGRPVLGTQKTYQWVPFHG 120

Query: 121 APNQCDLNCLAEGHAFYHSFGRVLDGTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRC 180
           APNQCDLNCLAEGHAFYHSFGRVLDGTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRC
Sbjct: 121 APNQCDLNCLAEGHAFYHSFGRVLDGTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRC 180

Query: 181 GRCGGANDSCLFVQRVFRDAGAFAGYWNVTLIPEGARHIRVEHRSRNHLALMGGDGRYVL 240
           GRCGGANDSCLFVQRVFRDAGAFAGYWNVTLIPEGARHIRVEHRSRNHLALMGGDGRYVL
Sbjct: 181 GRCGGANDSCLFVQRVFRDAGAFAGYWNVTLIPEGARHIRVEHRSRNHLALMGGDGRYVL 240

Query: 241 NGHWVVSPPGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWL 300
           NGHWVVSPPGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWL
Sbjct: 241 NGHWVVSPPGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWL 300

Query: 301 PRERYSPFQARVQALGWPLRQPQPRGVEPQPPAAPAVTPAQTPTLAPDPCPPCPDTRGRA 360
           PRERYSPFQARVQALGWPLRQPQPRGVEPQPPAAPAVTPAQTPTLAPDPCPPCPDTRGRA
Sbjct: 301 PRERYSPFQARVQALGWPLRQPQPRGVEPQPPAAPAVTPAQTPTLAPDPCPPCPDTRGRA 360

Query: 361 HRLLHYCGSDFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPLRAREYVWAPGHCPCPML 420
           HRLLHYCGSDFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPLRAREYVWAPGHCPCPML
Sbjct: 361 HRLLHYCGSDFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPLRAREYVWAPGHCPCPML 420

Query: 421 APHRDYLMAVQRLVSPDGTQDQLLLPHAGYARPWSPAEDSRIRLTARRCPG 471
           APHRDYLMAVQRLVSPDGTQDQLLLPHAGYARPWSPAEDSRIRLTARRCPG
Sbjct: 421 APHRDYLMAVQRLVSPDGTQDQLLLPHAGYARPWSPAEDSRIRLTARRCPG 471


>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif,
           6 preproprotein [Homo sapiens]
          Length = 1117

 Score =  210 bits (535), Expect = 2e-54
 Identities = 113/276 (40%), Positives = 148/276 (53%), Gaps = 9/276 (3%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRC---LRLPGEEPCWGDSHEYRLCQLPDCPPGAVP 92
           G W PW  W  CS +CG GVS   R C       G + C G+   YR C    CP G+  
Sbjct: 559 GGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRD 618

Query: 93  FRDLQCALYNGRPVLGTQKTYQWVPFHGAP-NQCDLNCLAEGHAFYHSFG-RVLDGTACS 150
           FR+ QCA ++  P  G  K Y W P+ G     C LNCLAEG+ FY      V+DGT C+
Sbjct: 619 FREKQCADFDNMPFRG--KYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCN 676

Query: 151 PGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYWNVT 210
             +  +C+ G C   GCD +LGS A EDRC  CGG   +C  ++  F D+    GY  V 
Sbjct: 677 ADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVV 736

Query: 211 LIPEGARHIRVEH--RSRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYTRDTGPQ 268
            IP G+ HI V     S+N++AL      Y +NG W +  P  ++ AGT   Y R T   
Sbjct: 737 QIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEP 796

Query: 269 ETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWLPRER 304
           E+L+A GPTS +L++ VLLQE N GI ++F +P  R
Sbjct: 797 ESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITR 832



 Score = 30.8 bits (68), Expect = 2.8
 Identities = 15/45 (33%), Positives = 22/45 (48%), Gaps = 3/45 (6%)

Query: 24   LNCGLGVSAQGPGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGE 68
            + C LG     P  W     W +CS+ CG G  +R+ +CL   G+
Sbjct: 1010 IRCSLGRCP--PPRWVTG-DWGQCSAQCGLGQQMRTVQCLSYTGQ 1051


>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
           sapiens]
          Length = 1074

 Score =  209 bits (533), Expect = 3e-54
 Identities = 129/341 (37%), Positives = 169/341 (49%), Gaps = 31/341 (9%)

Query: 33  QGPGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEE--PCWGDSHEYRLCQLPDCPPGA 90
           Q PG W P +S          G    S   L  P      C G+S + R C    CPP  
Sbjct: 333 QHPGAWLPLLS---------NGPHASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQ 383

Query: 91  VPFRDLQCALYNGRPVLGTQKTYQWVPFHGAPN--QCDLNCLAEGHAFY-HSFGRVLDGT 147
              R LQCA +N +  +G  + YQW PF       +C+LNC   G  FY     +V DGT
Sbjct: 384 PDPRALQCAAFNSQEFMG--QLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGT 441

Query: 148 ACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYW 207
            C PGA  +CVAGRCLS GCDG+LGSG   D CG CGG + +C  V     D G   GY 
Sbjct: 442 LCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQ 501

Query: 208 NVTLIPEGARHIRVE--HRSRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYT--- 262
            +  IP GA  +++     S N+LAL G  GR ++NG+W V PPG+Y A GT   Y    
Sbjct: 502 KILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPP 561

Query: 263 RDTGPQETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWLPRERYSPFQARVQALGWPLRQP 322
           R+ G  E+L A GPT+  + + ++ QE NPG+ +++ +      P          P+ Q 
Sbjct: 562 REEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISS---PPPILENPTPEPPVPQL 618

Query: 323 QPRGVEPQPPAAPAVTPAQTP-------TLAPDPCPPCPDT 356
           QP  +  +PP APA  PA+TP        +   P PP P T
Sbjct: 619 QPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRT 659



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 19/31 (61%), Positives = 19/31 (61%), Gaps = 1/31 (3%)

Query: 33 QGP-GEWTPWVSWTRCSSSCGRGVSVRSRRC 62
          QGP G W PWV W  CS  CG GV  RSR C
Sbjct: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71



 Score = 34.3 bits (77), Expect = 0.25
 Identities = 20/62 (32%), Positives = 27/62 (43%), Gaps = 14/62 (22%)

Query: 8   PRPHLFQNLLLFLWALLNCGLGVSAQGPGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPG 67
           PRP++ Q+  L L               G W     W++CS  CGRG   R  RC+   G
Sbjct: 770 PRPNITQSCQLRLC--------------GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG 815

Query: 68  EE 69
           +E
Sbjct: 816 DE 817



 Score = 30.0 bits (66), Expect = 4.7
 Identities = 27/96 (28%), Positives = 34/96 (35%), Gaps = 27/96 (28%)

Query: 34   GPGEWT-PWVS--WTRCSSSCGRGVSVRSRRCL-------------------RLPGEEPC 71
            GP E T  W +  W  CSS CG G   R   C+                   R P  +PC
Sbjct: 906  GPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPC 965

Query: 72   WGDSHEYRLCQLPDCP-----PGAVPFRDLQCALYN 102
             G + + R    P  P      G    R++QC   N
Sbjct: 966  QGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTN 1001


>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
           sapiens]
          Length = 877

 Score =  209 bits (533), Expect = 3e-54
 Identities = 129/341 (37%), Positives = 169/341 (49%), Gaps = 31/341 (9%)

Query: 33  QGPGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEE--PCWGDSHEYRLCQLPDCPPGA 90
           Q PG W P +S          G    S   L  P      C G+S + R C    CPP  
Sbjct: 333 QHPGAWLPLLS---------NGPHASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQ 383

Query: 91  VPFRDLQCALYNGRPVLGTQKTYQWVPFHGAPN--QCDLNCLAEGHAFY-HSFGRVLDGT 147
              R LQCA +N +  +G  + YQW PF       +C+LNC   G  FY     +V DGT
Sbjct: 384 PDPRALQCAAFNSQEFMG--QLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGT 441

Query: 148 ACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYW 207
            C PGA  +CVAGRCLS GCDG+LGSG   D CG CGG + +C  V     D G   GY 
Sbjct: 442 LCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQ 501

Query: 208 NVTLIPEGARHIRVE--HRSRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYT--- 262
            +  IP GA  +++     S N+LAL G  GR ++NG+W V PPG+Y A GT   Y    
Sbjct: 502 KILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPP 561

Query: 263 RDTGPQETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWLPRERYSPFQARVQALGWPLRQP 322
           R+ G  E+L A GPT+  + + ++ QE NPG+ +++ +      P          P+ Q 
Sbjct: 562 REEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISS---PPPILENPTPEPPVPQL 618

Query: 323 QPRGVEPQPPAAPAVTPAQTP-------TLAPDPCPPCPDT 356
           QP  +  +PP APA  PA+TP        +   P PP P T
Sbjct: 619 QPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRT 659



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 19/31 (61%), Positives = 19/31 (61%), Gaps = 1/31 (3%)

Query: 33 QGP-GEWTPWVSWTRCSSSCGRGVSVRSRRC 62
          QGP G W PWV W  CS  CG GV  RSR C
Sbjct: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71



 Score = 34.3 bits (77), Expect = 0.25
 Identities = 20/62 (32%), Positives = 27/62 (43%), Gaps = 14/62 (22%)

Query: 8   PRPHLFQNLLLFLWALLNCGLGVSAQGPGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPG 67
           PRP++ Q+  L L               G W     W++CS  CGRG   R  RC+   G
Sbjct: 770 PRPNITQSCQLRLC--------------GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG 815

Query: 68  EE 69
           +E
Sbjct: 816 DE 817


>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
           motif, 16 preproprotein [Homo sapiens]
          Length = 1224

 Score =  206 bits (524), Expect = 4e-53
 Identities = 116/311 (37%), Positives = 161/311 (51%), Gaps = 32/311 (10%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLP---GEEPCWGDSHEYRLCQLPDCPPGAVP 92
           G W+ W SW+ CS +CG GVS RSR C       G + C G +   +LC    CP  +V 
Sbjct: 587 GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVD 646

Query: 93  FRDLQCALYNGRPVLGTQKTYQWVPFHGAPNQ--CDLNCLAEGHAFYHSFG-RVLDGTAC 149
           FR  QCA +N R   G  + Y+W P+    +Q  C L C+AEG  F+ S   +V DGT C
Sbjct: 647 FRAAQCAEHNSRRFRG--RHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPC 704

Query: 150 SPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYWNV 209
           S  ++ VC+ G C   GCD +LGS A+ED CG C G N +C   + ++        Y+++
Sbjct: 705 SEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHM 764

Query: 210 TLIPEGARHIRVEHR--SRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYTRDTGP 267
             IP GAR IR+     S +++++     RY LNGHW V  PG Y+ +GT   Y R    
Sbjct: 765 VTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNE 824

Query: 268 QETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWLPRERYSPFQARVQALGWPLRQPQPRGV 327
            E L A GPT+  L++++L Q  NPG+ +E+ +PR                       G 
Sbjct: 825 PENLIATGPTNETLIVELLFQGRNPGVAWEYSMPR----------------------LGT 862

Query: 328 EPQPPAAPAVT 338
           E QPPA P+ T
Sbjct: 863 EKQPPAQPSYT 873



 Score = 33.9 bits (76), Expect = 0.33
 Identities = 15/34 (44%), Positives = 23/34 (67%), Gaps = 1/34 (2%)

Query: 31   SAQGPGEWTPWVS-WTRCSSSCGRGVSVRSRRCL 63
            +A GP   + + S W++C++SCG GV  RS +CL
Sbjct: 1121 AAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCL 1154


>gi|145309328 papilin [Homo sapiens]
          Length = 1251

 Score =  198 bits (503), Expect = 1e-50
 Identities = 115/303 (37%), Positives = 154/303 (50%), Gaps = 39/303 (12%)

Query: 16  LLLFLWALLNCGLGVSA----QGPGEWTPWVSWTRCSSSCGRGVSVRSRRCL--RLPGEE 69
           LLL +  LL    G SA    +    W PW  W+ CS +CG GVS R R C   R  G  
Sbjct: 3   LLLLVPLLLAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGS 62

Query: 70  PCWGDSHEYRLCQLPDCPPGAVPFRDLQCALYNGRPVLGTQKTYQWVPFHGAPNQCDLNC 129
            C G +  +R C+   CP GA  FR  QCA ++G    G  + Y+W+P++ APN+C+LNC
Sbjct: 63  SCVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQG--RRYRWLPYYSAPNKCELNC 120

Query: 130 LAEGHAFYHSFGR-VLDGTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGAND 188
           + +G  FY+     V+DGT C PG + VCV G C   GCD  L S   ED+C RCGG   
Sbjct: 121 IPKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGT 180

Query: 189 SCLFVQRVFRDAGAFAGYWNVTLIPEGARHIRVEHRSRNHLALMGGDGRYVLNGHWVVSP 248
           +C  V          AG ++   +    +++R               G Y LNGHW +  
Sbjct: 181 TCYPV----------AGTFDANDLSRAVKNVR---------------GEYYLNGHWTIEA 215

Query: 249 PGTYEAAGTHVVYTR----DTGPQETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWLPRER 304
                AA T + Y R    D  P E L A GPTS  L+++++ QEPNPG+ +E+ LP  R
Sbjct: 216 ARALPAASTILHYERGAEGDLAP-ERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRR 274

Query: 305 YSP 307
            SP
Sbjct: 275 PSP 277



 Score = 32.3 bits (72), Expect = 0.95
 Identities = 24/63 (38%), Positives = 25/63 (39%), Gaps = 7/63 (11%)

Query: 38  WTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLPDCPPGAVPFRDLQ 97
           W+P   W  CS SCG GV  RS  C    GE    G       C L D PP   P     
Sbjct: 400 WSP-EPWGECSVSCGVGVRKRSVTC---RGER---GSLLHTAACSLEDRPPLTEPCVHED 452

Query: 98  CAL 100
           C L
Sbjct: 453 CPL 455



 Score = 29.6 bits (65), Expect = 6.2
 Identities = 19/62 (30%), Positives = 24/62 (38%), Gaps = 1/62 (1%)

Query: 44  WTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLPDCPPGAVPFRDLQCALYNG 103
           W  CS+SCG G   RS  C+   G         E     LP  PP        +CA ++ 
Sbjct: 344 WAPCSASCGGGSQSRSVYCISSDG-AGIQEAVEEAECAGLPGKPPAIQACNLQRCAAWSP 402

Query: 104 RP 105
            P
Sbjct: 403 EP 404


>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
           18 preproprotein [Homo sapiens]
          Length = 1221

 Score =  191 bits (484), Expect = 2e-48
 Identities = 104/275 (37%), Positives = 144/275 (52%), Gaps = 10/275 (3%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLP---GEEPCWGDSHEYRLCQLPDCPPGAVP 92
           G+W+ W  W+ CS +CG GV  + R C       G   C G S  Y+LC +  C   ++ 
Sbjct: 590 GQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLD 649

Query: 93  FRDLQCALYNGRPVLGTQKTYQWVPFHGAPNQ--CDLNCLAEGHAFYHSF-GRVLDGTAC 149
           FR  QCA YN +P  G    YQW P+     +  C L C AE   F+ +  G+V DGT C
Sbjct: 650 FRAQQCAEYNSKPFRGW--FYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPC 707

Query: 150 SPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYWNV 209
           SP    VC+ G C   GCD  LGS A+ D CG C G N +C F + ++ +      Y+ V
Sbjct: 708 SPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPV 767

Query: 210 TLIPEGARHIRVEHR--SRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYTRDTGP 267
            LIP GAR I ++    S ++LA+     +Y L G W +  PG +  AGT   Y R    
Sbjct: 768 VLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNR 827

Query: 268 QETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWLPR 302
            E L A GPT+  L+ ++L+Q  NPGI +++ LP+
Sbjct: 828 PERLYAPGPTNETLVFEILMQGKNPGIAWKYALPK 862



 Score = 30.8 bits (68), Expect = 2.8
 Identities = 12/24 (50%), Positives = 16/24 (66%), Gaps = 2/24 (8%)

Query: 41   WV--SWTRCSSSCGRGVSVRSRRC 62
            WV  SW+ CS++CG GV  R  +C
Sbjct: 1056 WVASSWSECSATCGLGVRKREMKC 1079



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 28/95 (29%), Positives = 41/95 (43%), Gaps = 18/95 (18%)

Query: 35   PGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLPDCPPGAVPFR 94
            P +W+    W++CS +CGRG  VR R  L       C G + E     LP+    ++P  
Sbjct: 992  PPQWSLG-PWSQCSKTCGRG--VRKRELL-------CKGSAAE----TLPESQCTSLPRP 1037

Query: 95   DLQCALYNGRPVLGTQKTYQWVPFHGAPNQCDLNC 129
            +LQ     GR         QWV    + ++C   C
Sbjct: 1038 ELQEGCVLGR--CPKNSRLQWVA--SSWSECSATC 1068


>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
           10 preproprotein [Homo sapiens]
          Length = 1103

 Score =  185 bits (470), Expect = 7e-47
 Identities = 116/342 (33%), Positives = 163/342 (47%), Gaps = 28/342 (8%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRC---LRLPGEEPCWGDSHEYRLCQLPDCPPGAVP 92
           G W PW  W  CS +CG GVS  SR C       G + C G+   +R C   DCPPG+  
Sbjct: 548 GAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQD 607

Query: 93  FRDLQCALYNGRPVLGTQKTYQWVPFHGAP-NQCDLNCLAEGHAFY-HSFGRVLDGTACS 150
           FR++QC+ ++  P  G  K Y+W  + G     C L CLAEG  FY      V+DGT C 
Sbjct: 608 FREVQCSEFDSIPFRG--KFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCR 665

Query: 151 PGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYWNVT 210
           P    +CV+G C   GCD +LGS   ED+C  CGG   +C  ++ VF  A   AGY +V 
Sbjct: 666 PDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVV 725

Query: 211 LIPEGARHIRVE--HRSRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYTRDTGPQ 268
            IP+G+ HI ++  + S +HLAL G     +L G      P     AGT     +     
Sbjct: 726 WIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQGPDQV 785

Query: 269 ETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWLPRER---------YSPFQ---------A 310
           ++L+A GP +  L++ VL +   P + + F  P  R         Y+P+          +
Sbjct: 786 QSLEALGPINASLIVMVLARTELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQCAGGS 845

Query: 311 RVQALGWPLRQPQPRGVEPQPPAAPAVTPAQTPTLAPDPCPP 352
           +VQA+     Q     V P   +A +  P +      +PCPP
Sbjct: 846 QVQAVEC-RNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPP 886



 Score = 30.8 bits (68), Expect = 2.8
 Identities = 22/59 (37%), Positives = 24/59 (40%), Gaps = 11/59 (18%)

Query: 41  WV--SWTRCSSSCGRGVSVRSRRCLR--LPGEEPCWGDS-------HEYRLCQLPDCPP 88
           WV  +W+ CS SC  GV  RS  C R     EE    DS            C  P CPP
Sbjct: 888 WVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPP 946



 Score = 30.8 bits (68), Expect = 2.8
 Identities = 26/96 (27%), Positives = 36/96 (37%), Gaps = 22/96 (22%)

Query: 35   PGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLP-DCPPGAVPF 93
            P EW   + W+ C+ SCG G+  R   C            S ++R    P  C P A P 
Sbjct: 945  PPEWAA-LDWSECTPSCGPGLRHRVVLC-----------KSADHRATLPPAHCSPAAKPP 992

Query: 94   RDLQCALYNGRPVLGTQKTYQWVPFHGAPNQCDLNC 129
              ++C L    P        +WV   G   +C   C
Sbjct: 993  ATMRCNLRRCPPA-------RWVA--GEWGECSAQC 1019


>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
           sapiens]
          Length = 1018

 Score =  184 bits (468), Expect = 1e-46
 Identities = 94/237 (39%), Positives = 132/237 (55%), Gaps = 11/237 (4%)

Query: 71  CWGDSHEYRLCQLPDCPPGAVPFRDLQCALYNGRPVLGTQKTYQWVPFHGAPN--QCDLN 128
           C G   +Y+LC    CP  +   R++QCA YN +P +G  + Y+W PF       +C+LN
Sbjct: 291 CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMG--RFYEWEPFAEVKGNRKCELN 348

Query: 129 CLAEGHAFY-HSFGRVLDGTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGAN 187
           C A G+ FY     +V+DGT C      +CV+G+C S GCD  LGS  + D+CG CGG N
Sbjct: 349 CQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDN 408

Query: 188 DSCLFVQRVFRDAGAFAGYWNVTLIPEGARHIRVE--HRSRNHLALMGGDGRYVLNGHWV 245
             C  V  VF+ A    GY  V  IPEGA  I +   ++S N+LAL    GR ++NG+W 
Sbjct: 409 TGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWA 468

Query: 246 VSPPGTYEAAGTHVVYTR----DTGPQETLQAAGPTSHDLLLQVLLQEPNPGIEFEF 298
           +  PG YE  GT   Y R     +   E+  A GPT+  L + ++ Q+PNPG+ +E+
Sbjct: 469 IDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEY 525



 Score = 37.4 bits (85), Expect = 0.030
 Identities = 14/29 (48%), Positives = 17/29 (58%)

Query: 35 PGEWTPWVSWTRCSSSCGRGVSVRSRRCL 63
          PG W  W  W+ CS SC  GV  ++R CL
Sbjct: 53 PGVWGAWGPWSACSRSCSGGVMEQTRPCL 81



 Score = 29.3 bits (64), Expect = 8.1
 Identities = 12/32 (37%), Positives = 15/32 (46%)

Query: 37  EWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGE 68
           EW     WT CS  CG G   R  +C+   G+
Sbjct: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGD 769



 Score = 29.3 bits (64), Expect = 8.1
 Identities = 17/41 (41%), Positives = 21/41 (51%), Gaps = 7/41 (17%)

Query: 25  NCGLGVSAQGPGEW--TPWVSWTRCSSSCGRGVSVRSRRCL 63
           NC +G  A+    W  T W    RCS+ CG GV  RS  C+
Sbjct: 787 NCDMGPCAKS---WFLTEWSE--RCSAECGAGVRTRSVVCM 822


>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
           7 preproprotein [Homo sapiens]
          Length = 1686

 Score =  182 bits (461), Expect = 7e-46
 Identities = 105/277 (37%), Positives = 144/277 (51%), Gaps = 13/277 (4%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEP---CWGDSHEYRLCQLPDCPPGAVP 92
           G W+ W +W+ CS SCG GV    R+C +   +     C G+   +RLC L  CP G   
Sbjct: 539 GGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPS 598

Query: 93  FRDLQCALYNGRPVLGTQKTYQWVPFHGAPNQCDLNCLAEGHAFYHSF-GRVLDGTACSP 151
           FR +QC+ ++     G   T  WVP     N C+L+C      F       V+DGT C  
Sbjct: 599 FRHVQCSHFDAMLYKGQLHT--WVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQ 656

Query: 152 --GAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYWNV 209
              ++ +C+ G C + GCD  + SGA+EDRCG C G   +C  V   F +A    GY +V
Sbjct: 657 VRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGL-GYVDV 715

Query: 210 TLIPEGARHIRVEH--RSRNHLALMGGD-GRYVLNGHWVVSPPGTYEAAGTHVVYTRDTG 266
            LIP GAR IR++    + N LAL   D  +Y LNG W +   G Y+ AGT   Y R  G
Sbjct: 716 GLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYAR-RG 774

Query: 267 PQETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWLPRE 303
             E L + GPT   + +Q+L QE NPG+ +E+ + RE
Sbjct: 775 NWENLTSPGPTKEPVWIQLLFQESNPGVHYEYTIHRE 811



 Score = 32.7 bits (73), Expect = 0.73
 Identities = 34/110 (30%), Positives = 43/110 (39%), Gaps = 26/110 (23%)

Query: 39   TPWV--SWTRCSSSCGRGVSVRSRRCLR----LPGEE------PCWGDSHEYRLCQLPDC 86
            T WV   W +CS  CG GV  R  +C+     LP E+        W +S   R C   DC
Sbjct: 1571 TQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESS--RPCGTEDC 1628

Query: 87   PPGAVP--------FRDLQCALYNGRPVLGTQKTYQW----VPFHGAPNQ 124
             P   P        F   +     GR  L T +T        P HGAP++
Sbjct: 1629 EPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPPSHGAPSR 1678



 Score = 32.3 bits (72), Expect = 0.95
 Identities = 23/81 (28%), Positives = 34/81 (41%), Gaps = 29/81 (35%)

Query: 44  WTRCSSSCGRGVSVRSRRCL----------------------RLPGEEPC----WGDSHE 77
           WT+C+ +CGRGV  ++  CL                      R   E+PC    W  + E
Sbjct: 830 WTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWW--AGE 887

Query: 78  YRLCQLPDCPPGAVPFRDLQC 98
           ++LC    C PG +  R + C
Sbjct: 888 WQLCS-SSCGPGGLSRRAVLC 907



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 16/47 (34%), Positives = 24/47 (51%), Gaps = 10/47 (21%)

Query: 43   SWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLPDCPPG 89
            +W++CS SCG G SVR  +C+          D+ + R  +   C PG
Sbjct: 1470 NWSKCSRSCGGGSSVRDVQCV----------DTRDLRPLRPFHCQPG 1506


>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
           12 preproprotein [Homo sapiens]
          Length = 1594

 Score =  171 bits (434), Expect = 1e-42
 Identities = 101/278 (36%), Positives = 144/278 (51%), Gaps = 13/278 (4%)

Query: 35  PGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLP---GEEPCWGDSHEYRLCQLPDCPPGAV 91
           PG W  W  W+ CS +CG GV    R C       G + C G+   YRLC +  C   A 
Sbjct: 542 PGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAP 601

Query: 92  PFRDLQCALYNGRPVLGTQKTYQWVPFHGAPNQCDLNCLA-EGHAFYHSFGRVLDGTACS 150
            FR +QC+ ++  P     + Y W P     + C+L C   +G         V+DGT C 
Sbjct: 602 TFRQMQCSEFDTVPY--KNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCF 659

Query: 151 PG--AQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYWN 208
            G  ++ VC+ G C   GCD  + S A EDRCG C G   SC  V+++F+     +GY +
Sbjct: 660 EGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEG-SGYVD 718

Query: 209 VTLIPEGARHIRVE--HRSRNHLALMGGD-GRYVLNGHWVVSPPGTYEAAGTHVVYTRDT 265
           + LIP+GAR IRV     + N LA+   D  +Y LNG +++   G Y+ AGT   Y R  
Sbjct: 719 IGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDR-K 777

Query: 266 GPQETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWLPRE 303
           G  E L A GPT+  + +Q+L Q  NPGI++E+ + ++
Sbjct: 778 GDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKD 815



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 6/84 (7%)

Query: 23   LLNCGLGVSAQGPGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPC--WGDSHEYRL 80
            LL+C   +    P +WT   +W+ CS SCG GV +RS  C +   +EPC      +   L
Sbjct: 935  LLSCNRDILC--PSDWTVG-NWSECSVSCGGGVRIRSVTCAK-NHDEPCDVTRKPNSRAL 990

Query: 81   CQLPDCPPGAVPFRDLQCALYNGR 104
            C L  CP      +  +  + NG+
Sbjct: 991  CGLQQCPSSRRVLKPNKGTISNGK 1014



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 36/129 (27%), Positives = 47/129 (36%), Gaps = 10/129 (7%)

Query: 44   WTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRL-CQLPDCPPGAVPFRDLQCALYN 102
            W++CS SCG GV  R   C   PG    W       + C    C   A    DL      
Sbjct: 1432 WSQCSRSCGGGVQERGVFC---PGGLCDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCG 1488

Query: 103  GRPVLGTQK-TYQWVPFHGAPNQCDLNCLAEGHAFYHSFGRVLDGTACSPGAQGVCVAGR 161
            G    G QK T Q VP  G   +    CL +       F +  +  AC   A  +C   +
Sbjct: 1489 G----GFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEF-KKCNQQACKKSADLLCTKDK 1543

Query: 162  CLSAGCDGL 170
              ++ C  L
Sbjct: 1544 LSASFCQTL 1552



 Score = 29.6 bits (65), Expect = 6.2
 Identities = 24/87 (27%), Positives = 35/87 (40%), Gaps = 26/87 (29%)

Query: 25   NCGLGVSAQG---PG---EWTP---------------WVS--WTRCSSSCGRGVSVRSRR 61
            +CG GV  +G   PG   +WT                W +  W  CS+SCG G   R+ +
Sbjct: 1438 SCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQ 1497

Query: 62   CLRLPGEEPCWGDSHEYRLCQLPDCPP 88
            C+   G +    +  +  LC     PP
Sbjct: 1498 CVPSEGNKT---EDQDQCLCDHKPRPP 1521


>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
          Length = 951

 Score =  171 bits (432), Expect = 2e-42
 Identities = 112/300 (37%), Positives = 148/300 (49%), Gaps = 29/300 (9%)

Query: 38  WTPWVSWTRCSSSCGRGVSVRSRRCLRL-------PGEEPCWGDSHEYRLCQLPDCPPGA 90
           W  W  WT CS SCG GV+ + R CL+        PG   C G S  Y+LC++ +CPP  
Sbjct: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109

Query: 91  VPFRDLQCALYNGRPVLGTQKTYQWVPF------HGAPNQCDLNCLA-EGHAFYHSFGRV 143
             FR+ QC  +N     G  +T+QW P       H +   CDL+C   +G        R 
Sbjct: 110 RSFREEQCVSFNSHVYNG--RTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPAR- 166

Query: 144 LDGTACS-PGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGA 202
            DGT+C     +GVCV+G+C   GCDG+L S    D+CG C G   SC  V   +R   A
Sbjct: 167 -DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNA 225

Query: 203 FAGYWNVTLIPEGARHIRVEHR--SRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVV 260
             GY  VT IP GAR I++  R  S + LAL    G Y  NG++ V  P  +  AGT V 
Sbjct: 226 HLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVK 285

Query: 261 YTRDTGPQET----LQAAGPTSHDLLLQVLLQE-PNPGIEFEFWLPRERYSPFQARVQAL 315
           Y R     ET    + A GPT+  L + V  Q   +P I FE+ L +    P ++R Q +
Sbjct: 286 YRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQ---PPHESRPQPI 342



 Score = 34.3 bits (77), Expect = 0.25
 Identities = 17/50 (34%), Positives = 23/50 (46%), Gaps = 1/50 (2%)

Query: 35  PGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLP 84
           P  W     W RC+++CGRGV  R   C+ L   +P      E  L + P
Sbjct: 795 PAHWLAQ-DWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKP 843



 Score = 32.7 bits (73), Expect = 0.73
 Identities = 36/143 (25%), Positives = 52/143 (36%), Gaps = 42/143 (29%)

Query: 43  SWTRCSSSCGRGVSVRSRRCLRL--PG-EEPCWGD---------SHEYRLCQLPDCPP-- 88
           SW+ CS +CG G   R  RC ++  PG +   + D           E + C+ P C P  
Sbjct: 630 SWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQW 689

Query: 89  --------------GAVPFRDLQCAL------YNGRPV-----LGTQKTYQWVPFHGAPN 123
                          +V  RD++C+        N RPV      G     QW      P 
Sbjct: 690 EMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGP- 748

Query: 124 QCDLNCLAEGHAFYHSFGRVLDG 146
            C  +C  +G    H + +  DG
Sbjct: 749 -CSGSC-GQGRTIRHVYCKTSDG 769


>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
          Length = 951

 Score =  171 bits (432), Expect = 2e-42
 Identities = 112/300 (37%), Positives = 148/300 (49%), Gaps = 29/300 (9%)

Query: 38  WTPWVSWTRCSSSCGRGVSVRSRRCLRL-------PGEEPCWGDSHEYRLCQLPDCPPGA 90
           W  W  WT CS SCG GV+ + R CL+        PG   C G S  Y+LC++ +CPP  
Sbjct: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109

Query: 91  VPFRDLQCALYNGRPVLGTQKTYQWVPF------HGAPNQCDLNCLA-EGHAFYHSFGRV 143
             FR+ QC  +N     G  +T+QW P       H +   CDL+C   +G        R 
Sbjct: 110 RSFREEQCVSFNSHVYNG--RTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPAR- 166

Query: 144 LDGTACS-PGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGA 202
            DGT+C     +GVCV+G+C   GCDG+L S    D+CG C G   SC  V   +R   A
Sbjct: 167 -DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNA 225

Query: 203 FAGYWNVTLIPEGARHIRVEHR--SRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVV 260
             GY  VT IP GAR I++  R  S + LAL    G Y  NG++ V  P  +  AGT V 
Sbjct: 226 HLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVK 285

Query: 261 YTRDTGPQET----LQAAGPTSHDLLLQVLLQE-PNPGIEFEFWLPRERYSPFQARVQAL 315
           Y R     ET    + A GPT+  L + V  Q   +P I FE+ L +    P ++R Q +
Sbjct: 286 YRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQ---PPHESRPQPI 342



 Score = 34.3 bits (77), Expect = 0.25
 Identities = 17/50 (34%), Positives = 23/50 (46%), Gaps = 1/50 (2%)

Query: 35  PGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLP 84
           P  W     W RC+++CGRGV  R   C+ L   +P      E  L + P
Sbjct: 795 PAHWLAQ-DWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKP 843



 Score = 32.7 bits (73), Expect = 0.73
 Identities = 36/143 (25%), Positives = 52/143 (36%), Gaps = 42/143 (29%)

Query: 43  SWTRCSSSCGRGVSVRSRRCLRL--PG-EEPCWGD---------SHEYRLCQLPDCPP-- 88
           SW+ CS +CG G   R  RC ++  PG +   + D           E + C+ P C P  
Sbjct: 630 SWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQW 689

Query: 89  --------------GAVPFRDLQCAL------YNGRPV-----LGTQKTYQWVPFHGAPN 123
                          +V  RD++C+        N RPV      G     QW      P 
Sbjct: 690 EMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGP- 748

Query: 124 QCDLNCLAEGHAFYHSFGRVLDG 146
            C  +C  +G    H + +  DG
Sbjct: 749 -CSGSC-GQGRTIRHVYCKTSDG 769


>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
           motif, 4 preproprotein [Homo sapiens]
          Length = 837

 Score =  169 bits (428), Expect = 5e-42
 Identities = 119/312 (38%), Positives = 153/312 (49%), Gaps = 33/312 (10%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRCLR-LP--GEEPCWGDSHEYRLCQLPDCPPG-AV 91
           G W PW  W  CS +CG GV   SR C R +P  G + C G    +R C   DCP G A+
Sbjct: 521 GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSAL 580

Query: 92  PFRDLQCALYNGRPVL--GTQKTYQWVPFHG--AP-NQCDLNCLAEGHAFYHSFG-RVLD 145
            FR+ QCA YN R  L         WVP +   AP +QC L C A+   +Y+    RV+D
Sbjct: 581 TFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVD 640

Query: 146 GTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFA- 204
           GT CSP +  VCV GRC+ AGCD ++GS    D+C  CGG    C       + +G+F  
Sbjct: 641 GTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGC------SKQSGSFRK 694

Query: 205 ---GYWNVTLIPEGARHIRVE------HRSRNHLALMGGDGRYVLNGHWVV--SPPGTYE 253
              GY NV  IP GA HI V       HRS  +LAL   DG Y LNG + +  SP     
Sbjct: 695 FRYGYNNVVTIPAGATHILVRQQGNPGHRS-IYLALKLPDGSYALNGEYTLMPSPTDVVL 753

Query: 254 AAGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLL--QEPNPGIEFEFWLPRERYSPFQAR 311
                + Y+  T   ETL   GP +  L LQVL+     +  + + F++PR   +P   R
Sbjct: 754 PGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPRP--TPSTPR 811

Query: 312 VQALGWPLRQPQ 323
                W  R+ Q
Sbjct: 812 PTPQDWLHRRAQ 823


>gi|112789555 ADAM metallopeptidase with thrombospondin type 1
           motif, 19 preproprotein [Homo sapiens]
          Length = 1207

 Score =  165 bits (417), Expect = 9e-41
 Identities = 101/268 (37%), Positives = 134/268 (50%), Gaps = 9/268 (3%)

Query: 41  WVSWTRCSSSCGRGVSVRSRRCLRLPGE-EPCWGDSHEYRLCQLPDCPPGAVPFRDLQCA 99
           W  W+ CS +C  G+S R R+C  L  E   C G   +YR+C+ P CP G   FRD QC 
Sbjct: 639 WSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQ 698

Query: 100 LYNGRPVLGTQKTYQWVPFHGAPNQCDLNCLAEGHAFYHSFG-RVLDGTACSPGAQGVCV 158
            Y+ R     +   QW         C L C   G         +V+DGT+C      +C 
Sbjct: 699 AYSVR-TSSPKHILQWQAVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICA 757

Query: 159 AGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYWNVTLIPEGARH 218
            GRC   GCDGLLGS A ED CG C G   SC  ++  F      AGY  V +IP GAR 
Sbjct: 758 NGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRG-AGYVEVLVIPAGARR 816

Query: 219 IRV--EHRSRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYTRDTGPQETLQAAGP 276
           I+V  E  + ++LAL    G+  +N  W +   G +  AGT V Y R  G  E + A GP
Sbjct: 817 IKVVEEKPAHSYLALRDA-GKQSINSDWKIEHSGAFNLAGTTVHYVR-RGLWEKISAKGP 874

Query: 277 TSHDL-LLQVLLQEPNPGIEFEFWLPRE 303
           T+  L LL +L Q+ N G+ +E+ +P +
Sbjct: 875 TTAPLHLLVLLFQDQNYGLHYEYTIPSD 902



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 15/48 (31%), Positives = 25/48 (52%), Gaps = 5/48 (10%)

Query: 44   WTRCSSSCGRGVSVRSRRCL-RLPGE--EPCWGDSH--EYRLCQLPDC 86
            W++CS +CG+G+  R  +C+ ++ G     C+       YR C L  C
Sbjct: 1096 WSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPC 1143


>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
           type) with thrombospondin type 1 motif, 15 preproprotein
           [Homo sapiens]
          Length = 950

 Score =  159 bits (402), Expect = 5e-39
 Identities = 117/360 (32%), Positives = 162/360 (45%), Gaps = 45/360 (12%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRCLR---LPGEEPCWGDSHEYRLCQLPDCPPGAV- 91
           G W  W  +  CS +CG GV +  R+C       G + C G   +YR C L  CP  A  
Sbjct: 517 GSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASG 576

Query: 92  -PFRDLQCALYNGRPVLGTQKTYQ--WVPFHGAPN---QCDLNCLAEGHAFYHSFG-RVL 144
             FR+ QC  +NG      + T    WVP +   +   +C L C A G  +++    +V+
Sbjct: 577 KSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVV 636

Query: 145 DGTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFA 204
           DGT CSP +  VCV G+C+ AGCDG LGS    D+CG CGG N SC  V  +F       
Sbjct: 637 DGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLF--TKPMH 694

Query: 205 GYWNVTLIPEGARHIRVEHR-------SRNHLALMGGDGRYVLNGHWVVSP-PGTYEAAG 256
           GY  V  IP GA  I +  R         N+LAL    G+Y+LNGH+VVS         G
Sbjct: 695 GYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKG 754

Query: 257 THVVYTRDTGPQETLQAAGPTSHDLLLQVLL--QEPNPGIEFEFWLPRERYSPFQARVQA 314
           + + Y+      E+LQA+ P    L ++VL   +   P + + F+LP+E           
Sbjct: 755 SLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKE----------- 803

Query: 315 LGWPLRQPQPRGVEPQPPAAPAVTPAQTPTLA-----PDPCPPCPDTRGRAHRLLHYCGS 369
                   + +   P+ P  P+V      +L+     PD  PP     G        CGS
Sbjct: 804 ------PREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCGS 857



 Score = 32.7 bits (73), Expect = 0.73
 Identities = 20/49 (40%), Positives = 25/49 (51%), Gaps = 7/49 (14%)

Query: 30  VSAQGPGEWTP-WV--SWTRCSSSCGRGVSVRSRRCL----RLPGEEPC 71
           V  Q  GE  P W   +W+ CS SCGRG   RS +C+    RL   + C
Sbjct: 885 VETQACGEPCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQC 933



 Score = 29.3 bits (64), Expect = 8.1
 Identities = 20/58 (34%), Positives = 26/58 (44%), Gaps = 7/58 (12%)

Query: 35  PGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEE--PCWGDSH---EYRLCQLPDCP 87
           P  W    SW  CS+SCG G+  R+  C    G+   P    +H   E + C  P CP
Sbjct: 840 PARWVAG-SWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEP-CP 895


>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
           motif, 5 preproprotein [Homo sapiens]
          Length = 930

 Score =  159 bits (401), Expect = 7e-39
 Identities = 100/294 (34%), Positives = 140/294 (47%), Gaps = 23/294 (7%)

Query: 31  SAQGPGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEP---CWGDSHEYRLCQLPDCP 87
           S    G W  W SW +CS SCG GV    R C           C G    YR C L  CP
Sbjct: 563 STSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCP 622

Query: 88  PGAVPFRDLQCALYNG--RPVLGTQKTYQWVPFHGA---PNQCDLNCLAEGHAFYHSFG- 141
           P    FR  QC   NG      G +   +WVP +      + C L C A+G  +Y  F  
Sbjct: 623 PNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSP 682

Query: 142 RVLDGTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAG 201
           +V DGT C   +  VCV G+C+  GCDG++GS    D+CG CGG N SC  +   F    
Sbjct: 683 KVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKS 742

Query: 202 AFAGYWNVTLIPEGARHIRV-------EHRSRNHLALMGGDGRYVLNGHWVVSPPGT-YE 253
              GY +V  IPEGA HI+V       + R   +LAL   +G Y++NG +++S   T  +
Sbjct: 743 --KGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIID 800

Query: 254 AAGTHVVYTRDTGPQETLQAAG--PTSHDLLLQVLLQEPNP--GIEFEFWLPRE 303
             GT + Y+  +   + L   G   T   L++Q+L  +P     + + F++P++
Sbjct: 801 INGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKK 854


>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
           1 preproprotein [Homo sapiens]
          Length = 967

 Score =  157 bits (396), Expect = 3e-38
 Identities = 116/375 (30%), Positives = 171/375 (45%), Gaps = 53/375 (14%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRC---LRLPGEEPCWGDSHEYRLCQLPDCPPG-AV 91
           G W  W  W  CS +CG GV    R C   +   G + C G    YR C L DCP     
Sbjct: 560 GSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGK 619

Query: 92  PFRDLQCALYN--GRPVLGTQKTYQWVPFHGA---PNQCDLNCLAEGHAFYHSFG-RVLD 145
            FR+ QC  +N   +   G+    +W+P +      ++C L C A+G  ++     +V+D
Sbjct: 620 TFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVD 679

Query: 146 GTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAG 205
           GT CSP +  VCV G+C+ AGCD ++ S    D+CG CGG   +C  +        A  G
Sbjct: 680 GTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSV--TSAKPG 737

Query: 206 YWNVTLIPEGARHIRVEHR----SRNH---LALMGGDGRYVLNGHWVVSPPGTYEA---- 254
           Y ++  IP GA +I V+ R    SRN+   LA+   DG Y+LNG + +S   T E     
Sbjct: 738 YHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLS---TLEQDIMY 794

Query: 255 AGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLL--QEPNPGIEFEFWLPRERYS-----P 307
            G  + Y+  +   E +++  P    L +QVL       P I++ +++ +++ S      
Sbjct: 795 KGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPT 854

Query: 308 FQARV----------QALGWPLRQPQPRGVEPQPPA--APAVTPAQTPTLAPDPCP---- 351
           F A V            LGW  R  + R +  QP +  A  V PA T   A  PCP    
Sbjct: 855 FSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQL 914

Query: 352 ----PCPDTRGRAHR 362
                C  T G+ ++
Sbjct: 915 GEWSSCSKTCGKGYK 929



 Score = 32.3 bits (72), Expect = 0.95
 Identities = 15/50 (30%), Positives = 22/50 (44%), Gaps = 7/50 (14%)

Query: 44  WTRCSSSCGRGVSVRSRRCLRLPGE-------EPCWGDSHEYRLCQLPDC 86
           W+ CS +CG+G   RS +CL   G        +P     H    C + +C
Sbjct: 917 WSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966


>gi|124430557 a disintegrin-like and metalloprotease with
           thrombospondin type 1 motifs 20 [Homo sapiens]
          Length = 1910

 Score =  155 bits (391), Expect = 1e-37
 Identities = 94/291 (32%), Positives = 142/291 (48%), Gaps = 22/291 (7%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLP---GEEPCWGDSHEYRLCQLPDCPPGAVP 92
           GEW PW  ++ CS +CG G+   +RRC R     G   C G   ++R C    CP G   
Sbjct: 557 GEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQD 616

Query: 93  FRDLQCALYNGR--PVLGTQKTYQWVPFH---GAPNQCDLNCLAEG-HAFYHSFGRVLDG 146
           FR+ QC+ +NG+   + G     +W+P +   G  ++C L C   G + FY     V DG
Sbjct: 617 FREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDG 676

Query: 147 TACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGY 206
           T C      +CV G+C++AGCD +L S A  D+CG CGG N SC  +  VF    +  GY
Sbjct: 677 TPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFN--SSHYGY 734

Query: 207 WNVTLIPEGARHIRVEHRS------RNHLALMGGDGRYVLNGHWVVSPPG---TYEAAGT 257
             V  IP GA ++ +   S       ++LAL   +G ++ NG++++S        +   T
Sbjct: 735 NVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRT 794

Query: 258 HVVYTRDTGPQETLQAAGPTSHDLLLQVLL--QEPNPGIEFEFWLPRERYS 306
            + Y+      E + +      +L+LQVL      NP + + F +P E  S
Sbjct: 795 VIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERS 845



 Score = 32.3 bits (72), Expect = 0.95
 Identities = 19/48 (39%), Positives = 23/48 (47%), Gaps = 7/48 (14%)

Query: 43   SWTRCSSSCGRGVSVRSRRCL----RLPGEEPCWGDSHEYRLCQLPDC 86
            SWT CS SCGRG   R   C     R+  E  C   +H  R  ++ DC
Sbjct: 1160 SWTPCSVSCGRGTQARYVSCRDALDRIADESYC---AHLPRPAEIWDC 1204



 Score = 32.3 bits (72), Expect = 0.95
 Identities = 37/143 (25%), Positives = 52/143 (36%), Gaps = 33/143 (23%)

Query: 34   GPGEWTPWV--SWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLPDCPPGAV 91
            GPG    W   +W  CS +CG G+  R   C + P      G   E   C++ + PP  +
Sbjct: 1355 GPGPCPQWNYGNWGECSQTCGGGIKSRLVIC-QFPN-----GQILEDHNCEIVNKPPSVI 1408

Query: 92   PFRDLQCALYNGRPVLGTQKTYQWVPFHGAP-NQCDLNCLAEGHAF-----YHSFGRVLD 145
                 QC ++             W   H  P   C  +C  +G  +        F R L+
Sbjct: 1409 -----QCHMH------ACPADVSW---HQEPWTSCSASC-GKGRKYREVFCIDQFQRKLE 1453

Query: 146  GTACS----PGAQGVCVAGRCLS 164
             T CS    P     C + RC S
Sbjct: 1454 DTNCSQVQKPPTHKACRSVRCPS 1476



 Score = 30.8 bits (68), Expect = 2.8
 Identities = 19/58 (32%), Positives = 25/58 (43%), Gaps = 6/58 (10%)

Query: 36   GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLP---GEEPCWGDSHEY--RLCQLPDCPP 88
            GEW     W+ CS+SCG G + R   C+       E  C  +      + C L  CPP
Sbjct: 1209 GEWQAG-DWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPP 1265



 Score = 29.3 bits (64), Expect = 8.1
 Identities = 16/49 (32%), Positives = 23/49 (46%), Gaps = 1/49 (2%)

Query: 44   WTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLPDCPPGAVP 92
            W  CSSSC  G+  R+  C    G+   + D+   +  +L  C PG  P
Sbjct: 1313 WGSCSSSCSGGLQHRAVVCQDENGQSASYCDAAS-KPPELQQCGPGPCP 1360



 Score = 29.3 bits (64), Expect = 8.1
 Identities = 20/51 (39%), Positives = 22/51 (43%), Gaps = 8/51 (15%)

Query: 43   SWTRCSSSCGRGVSVRSRRCLRLPG-----EEPCWGDSH--EYRLCQLPDC 86
            SW  CS +CG GV  R   C RL G     EE C   +     R C   DC
Sbjct: 1481 SWNECSVTCGSGVQQRDVYC-RLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530


>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
           motif, 8 preproprotein [Homo sapiens]
          Length = 889

 Score =  152 bits (383), Expect = 8e-37
 Identities = 97/288 (33%), Positives = 135/288 (46%), Gaps = 23/288 (7%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLP---GEEPCWGDSHEYRLCQLPDCPPGAVP 92
           G W PW  W  CS +CG GV    R C       G   C G   +Y+ C   +CPP    
Sbjct: 527 GGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKS 586

Query: 93  FRDLQCALYNGRPVLGTQ-KTYQWVPFHGAPN---QCDLNCLAEGHAFYHSF-GRVLDGT 147
           FR+ QC  YN            QWVP +   +   +C L C A G + +  F  +V+DGT
Sbjct: 587 FREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGT 646

Query: 148 ACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYW 207
            C P    +CV G+C+ AGCD ++ S    D+CG CGG  +SC  V           GY 
Sbjct: 647 LCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTN--YGYN 704

Query: 208 NVTLIPEGARHIRVEHRSR-------NHLALMGGDGRYVLNGHWVVSP-PGTYEAAGTHV 259
           ++  IP GA +I V+ RS        N+LAL   DG+Y+LNG+  +S         GT +
Sbjct: 705 DIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTIL 764

Query: 260 VYTRDTGPQETLQAAGPTSHDLLLQVLLQEPN----PGIEFEFWLPRE 303
            Y+      E LQ+  P    L +Q LL  P     P +++ F++P +
Sbjct: 765 KYSGSIATLERLQSFRPLPEPLTVQ-LLTVPGEVFPPKVKYTFFVPND 811


>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
           motif, 17 preproprotein [Homo sapiens]
          Length = 1095

 Score =  143 bits (361), Expect = 3e-34
 Identities = 110/354 (31%), Positives = 150/354 (42%), Gaps = 48/354 (13%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLP---GEEPCWGDSHEYRLCQLPDCPPGAVP 92
           G+W+PW +W+ CS +CG G   R R+C   P   G   C G S E+ +C+   CP G   
Sbjct: 544 GDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPS 603

Query: 93  FRDLQCALYNGRPVLGTQKTYQWVPFHGAPNQCDLNCLAEG-HAFYHSFGRVLDGTACSP 151
           FRD QC  ++    L  +K             C+L C   G  +      RVLDGT C P
Sbjct: 604 FRDQQCQAHDR---LSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGP 660

Query: 152 GAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYWNVTL 211
               +CV G+C   GCDG++GS A EDRCG C G   +C  V+  F  A   A       
Sbjct: 661 YETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTA------- 713

Query: 212 IPEGARHIRVEHRSRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYTRDTGPQETL 271
                               +   G+  +N  W +  PG ++ AGT V Y R  G  E +
Sbjct: 714 --------------------LKDSGKGSINSDWKIELPGEFQIAGTTVRYVR-RGLWEKI 752

Query: 272 QAAGPTSHDLLLQVLL-QEPNPGIEFEFWLPRERYSPFQARVQA----------LGWPLR 320
            A GPT   L L VLL  + + GI +E+ +P  R +  Q+  +            GW   
Sbjct: 753 SAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGC 812

Query: 321 QPQPRGVEPQPPAAPAVTPAQTPTLAPD-PCPPCPDTRGRAHRL-LHYCGSDFV 372
             Q  G E +   +      +T TL  D  CP       +  R  LH C S +V
Sbjct: 813 SVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWV 866



 Score = 31.2 bits (69), Expect = 2.1
 Identities = 16/48 (33%), Positives = 22/48 (45%), Gaps = 5/48 (10%)

Query: 44   WTRCSSSCGRGVSVRSRRCL-----RLPGEEPCWGDSHEYRLCQLPDC 86
            W+ CSS+CG+G+  R  +C+     R   E P       YR C    C
Sbjct: 981  WSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 11/25 (44%), Positives = 17/25 (68%)

Query: 44  WTRCSSSCGRGVSVRSRRCLRLPGE 68
           W++CS+SCG+GV  R+  C    G+
Sbjct: 930 WSQCSASCGKGVWKRTVACTNSQGK 954


>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif,
           9 preproprotein [Homo sapiens]
          Length = 1935

 Score =  143 bits (360), Expect = 4e-34
 Identities = 97/287 (33%), Positives = 133/287 (46%), Gaps = 21/287 (7%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLP---GEEPCWGDSHEYRLCQLPDCPPGAVP 92
           G W  W  +  CS +CG G+    R C R     G + C G   +++ C    C      
Sbjct: 589 GSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRD 648

Query: 93  FRDLQCALYNGRP--VLGTQKTYQWVPFHGA---PNQCDLNCLAEGH-AFYHSFGRVLDG 146
           FRD QCA ++G+   + G     +WVP +      ++C L C   G+ A+Y    RV+DG
Sbjct: 649 FRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDG 708

Query: 147 TACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGY 206
           T C      +CV G C  AGCD +L S A  D+CG CGG N SC  V   F       GY
Sbjct: 709 TPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNT--VHYGY 766

Query: 207 WNVTLIPEGARHIRVEHRS-------RNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHV 259
             V  IP GA +I V   S        N+LAL    G ++LNG++VV+        G  V
Sbjct: 767 NTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAV 826

Query: 260 V-YTRDTGPQETLQAAGPTSHDLLLQVLL--QEPNPGIEFEFWLPRE 303
           V Y+      E + +      +LLLQVL   +  NP + + F +P E
Sbjct: 827 VEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNIPIE 873



 Score = 33.5 bits (75), Expect = 0.43
 Identities = 19/51 (37%), Positives = 25/51 (49%), Gaps = 6/51 (11%)

Query: 43   SWTRCSSSCGRGVSVRSRRCL----RLPGEEPC--WGDSHEYRLCQLPDCP 87
            +W++CS SCGRGV  R   C     ++  E  C  +      R CQ P CP
Sbjct: 1505 AWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCP 1555



 Score = 32.3 bits (72), Expect = 0.95
 Identities = 17/57 (29%), Positives = 30/57 (52%), Gaps = 8/57 (14%)

Query: 44   WTRCSSSCGRGVSVRSRRC-----LRLPGEEPCWGDSH--EYRLCQLPDC-PPGAVP 92
            W +CS +CG+G  +R+ +C     + +  +  C   +   + + C+LP C PP A P
Sbjct: 1116 WGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAP 1172



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 22/69 (31%), Positives = 30/69 (43%), Gaps = 7/69 (10%)

Query: 44   WTRCSSSCGRGVSVRSRRCLRLPG----EEPC--WGDSHEYRLCQLPDCPPGAVPFRDLQ 97
            W+ CS SCGRG   R+  C+   G     + C      H +R C+   CP         Q
Sbjct: 1450 WSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAGAWS-Q 1508

Query: 98   CALYNGRPV 106
            C++  GR V
Sbjct: 1509 CSVSCGRGV 1517



 Score = 29.6 bits (65), Expect = 6.2
 Identities = 25/92 (27%), Positives = 38/92 (41%), Gaps = 17/92 (18%)

Query: 41   WVS--WTRCSSSCGRGVSVRSRRCLRL-PGEEPCWGDSHEYRLCQLPDCPPGAVPFRDLQ 97
            W++  W+ CS +CG+G   R   C  +  G+E     ++EY      +C PG  P     
Sbjct: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKE-----NYEYSYQTTINC-PGTQPPSVHP 1669

Query: 98   CALYNGRPVLGTQKTYQWVPFHGAPNQCDLNC 129
            C L    PV  T +   W         C ++C
Sbjct: 1670 CYL-RDCPVSATWRVGNW-------GSCSVSC 1693



 Score = 29.3 bits (64), Expect = 8.1
 Identities = 10/20 (50%), Positives = 14/20 (70%)

Query: 43   SWTRCSSSCGRGVSVRSRRC 62
            SWT CS++CG+G  +R   C
Sbjct: 1190 SWTPCSATCGKGTRMRYVSC 1209


>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
          Length = 1762

 Score =  138 bits (348), Expect = 9e-33
 Identities = 98/297 (32%), Positives = 138/297 (46%), Gaps = 23/297 (7%)

Query: 16  LLLFLWALLNCGLGVSAQGP--GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWG 73
           LLLFL  LL       ++    G W  W  W+ CS +CG G S   RRCL     + C G
Sbjct: 12  LLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCL---SSKSCEG 68

Query: 74  DSHEYRLCQLPDCPPGAVPFRDLQCALYNGRPVLGTQKTYQWVPFHGAP-NQCDLNCLAE 132
            +  YR C   DCPP A  FR  QC+ +N     G  + Y+W+P    P N C L C A+
Sbjct: 69  RNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHG--QFYEWLPVSNDPDNPCSLKCQAK 126

Query: 133 GHAFYHSFG-RVLDGTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCL 191
           G         +VLDGT C   +  +C++G C   GCD  LGS   ED CG C G   +C 
Sbjct: 127 GTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCR 186

Query: 192 FVQRVFR-DAGAFAGYWNVTLIPEGARHIRVEHRSRNHL-----ALMGGDGRYVLNGHWV 245
            V+  ++    A      V  IP G+RHIR+  +  +HL      L G  G   L     
Sbjct: 187 LVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSL----- 241

Query: 246 VSPPGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLLQ-EPNPGIEFEFWLP 301
            S  GT+    + V + +    +E L+ AGP + D ++++      +  ++F F+ P
Sbjct: 242 -SSTGTFLVDNSSVDFQK-FPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQP 296



 Score = 34.3 bits (77), Expect = 0.25
 Identities = 14/31 (45%), Positives = 17/31 (54%), Gaps = 1/31 (3%)

Query: 35  PGEWTPWVSWTRCSSSCGRGVSVRSRRCLRL 65
           P EW     WT CS+SCG G   RS  C ++
Sbjct: 789 PSEWL-LSDWTECSTSCGEGTQTRSAICRKM 818



 Score = 30.8 bits (68), Expect = 2.8
 Identities = 11/20 (55%), Positives = 14/20 (70%)

Query: 44  WTRCSSSCGRGVSVRSRRCL 63
           WT CSSSCG G+  R+  C+
Sbjct: 385 WTACSSSCGGGIQSRAVSCV 404



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 13/31 (41%), Positives = 16/31 (51%), Gaps = 1/31 (3%)

Query: 35   PGEWTPWVSWTRCSSSCGRGVSVRSRRCLRL 65
            P  W    SW+ C+ SCG GV  R   C +L
Sbjct: 1546 PSRWMV-TSWSACTRSCGGGVQTRRVTCQKL 1575



 Score = 29.3 bits (64), Expect = 8.1
 Identities = 17/45 (37%), Positives = 19/45 (42%), Gaps = 5/45 (11%)

Query: 44  WTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLPDCPP 88
           +T+CS SCG GV      CL     EP      E  LC     PP
Sbjct: 616 FTKCSESCGGGVQEAVVSCLNKQTREPA-----EENLCVTSRRPP 655


>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
          Length = 525

 Score =  138 bits (348), Expect = 9e-33
 Identities = 98/297 (32%), Positives = 138/297 (46%), Gaps = 23/297 (7%)

Query: 16  LLLFLWALLNCGLGVSAQGP--GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWG 73
           LLLFL  LL       ++    G W  W  W+ CS +CG G S   RRCL     + C G
Sbjct: 12  LLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCL---SSKSCEG 68

Query: 74  DSHEYRLCQLPDCPPGAVPFRDLQCALYNGRPVLGTQKTYQWVPFHGAP-NQCDLNCLAE 132
            +  YR C   DCPP A  FR  QC+ +N     G  + Y+W+P    P N C L C A+
Sbjct: 69  RNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHG--QFYEWLPVSNDPDNPCSLKCQAK 126

Query: 133 GHAFYHSFG-RVLDGTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCL 191
           G         +VLDGT C   +  +C++G C   GCD  LGS   ED CG C G   +C 
Sbjct: 127 GTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCR 186

Query: 192 FVQRVFR-DAGAFAGYWNVTLIPEGARHIRVEHRSRNHL-----ALMGGDGRYVLNGHWV 245
            V+  ++    A      V  IP G+RHIR+  +  +HL      L G  G   L     
Sbjct: 187 LVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSL----- 241

Query: 246 VSPPGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLLQ-EPNPGIEFEFWLP 301
            S  GT+    + V + +    +E L+ AGP + D ++++      +  ++F F+ P
Sbjct: 242 -SSTGTFLVDNSSVDFQK-FPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQP 296



 Score = 30.8 bits (68), Expect = 2.8
 Identities = 11/20 (55%), Positives = 14/20 (70%)

Query: 44  WTRCSSSCGRGVSVRSRRCL 63
           WT CSSSCG G+  R+  C+
Sbjct: 385 WTACSSSCGGGIQSRAVSCV 404


>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
          Length = 1691

 Score =  137 bits (344), Expect = 3e-32
 Identities = 87/275 (31%), Positives = 123/275 (44%), Gaps = 21/275 (7%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLPDCPPGAVPFRD 95
           G W  W  W+ CS +CG G S   RRCL       C G +  Y+ C   DCPP A  FR 
Sbjct: 76  GNWDAWGDWSDCSRTCGGGASYSLRRCLT---GRNCEGQNIRYKTCSNHDCPPDAEDFRA 132

Query: 96  LQCALYNGRPVLGTQKTYQWVPFHGAPNQ-CDLNCLAEGHAFYHSFG-RVLDGTACSPGA 153
            QC+ YN     G    Y+W+P +  P   C L C A+G         +VLDGT C+  +
Sbjct: 133 QQCSAYNDVQYQGHY--YEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDS 190

Query: 154 QGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRD-AGAFAGYWNVTLI 212
             +C++G C + GCD  LGS A ED CG C G   +C  V+   +          NV  +
Sbjct: 191 LDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREENVIAV 250

Query: 213 PEGARHIRVEHRSRNHL-----ALMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYTRDTGP 267
           P G+R +R+  +   HL      L G  G +  N       PG +    T V + R +  
Sbjct: 251 PLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNS------PGVFLVENTTVEFQRGS-E 303

Query: 268 QETLQAAGPTSHDLLLQVLLQEPNPG-IEFEFWLP 301
           ++T +  GP   D + +          ++F F+ P
Sbjct: 304 RQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQP 338



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 21/53 (39%), Positives = 26/53 (49%), Gaps = 7/53 (13%)

Query: 43  SWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDS------HEYRLCQLPDCPPG 89
           SW  CS++CG G+  R   CL  PGE P   +       H  + C   DCPPG
Sbjct: 711 SWGPCSATCGVGIQTRDVYCLH-PGETPAPPEECRDEKPHALQACNQFDCPPG 762



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 10/53 (18%)

Query: 44  WTRCSSSCGRGVSVRSRRCLRL-------PGEEPCWGDSHE---YRLCQLPDC 86
           W++CS SCG G+  R + C RL       P  E    D       R CQ+P+C
Sbjct: 828 WSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPEC 880



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 17/54 (31%), Positives = 24/54 (44%), Gaps = 9/54 (16%)

Query: 44  WTRCSSSCGRGVSVRSRRCLRL--------PGEEPCWG-DSHEYRLCQLPDCPP 88
           W +CS +CG G   R   C +L          +E C G  +  ++ C   DCPP
Sbjct: 768 WQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPP 821



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 26/91 (28%), Positives = 30/91 (32%), Gaps = 17/91 (18%)

Query: 35   PGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLPDCPPGAVPFR 94
            P  W   V W++CS SCG G   R   C R          S   R C   D P G  P  
Sbjct: 1484 PARWFTSV-WSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSP--RACAPKDRPLGRKPCF 1540

Query: 95   DLQCALYNGRPVLGTQKTYQWVPFHGAPNQC 125
               C               QW P +  P +C
Sbjct: 1541 GHPCV--------------QWEPGNRCPGRC 1557



 Score = 30.8 bits (68), Expect = 2.8
 Identities = 30/102 (29%), Positives = 39/102 (38%), Gaps = 21/102 (20%)

Query: 44  WTRCSSSCGRGVSVRSRRC----------LRLPGEEPCWGDS-HEYRLCQLPDCPPGAVP 92
           W+ CS++CG GV VR  +C            LP EE C G      R C L  C      
Sbjct: 573 WSACSTTCGPGVQVREVKCRVLLTFTQTETELP-EEECEGPKLPTERPCLLEACDESPAS 631

Query: 93  FRDLQCALYNGRPVLGTQKTYQWVPFHGAPNQCDLNCLAEGH 134
            R+L   L        ++ TY W   +     C   C+  GH
Sbjct: 632 -RELDIPLPE-----DSETTYDWE--YAGFTPCTATCVG-GH 664



 Score = 29.6 bits (65), Expect = 6.2
 Identities = 23/75 (30%), Positives = 30/75 (40%), Gaps = 19/75 (25%)

Query: 44  WTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHE--------------YRLCQLPDCPPG 89
           WT CS SCG G+  RS  C+    EE   G+  +               + C L DCP  
Sbjct: 427 WTACSVSCGGGIQRRSFVCV----EESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKW 482

Query: 90  AVPFRDLQCALYNGR 104
            +     QC +  GR
Sbjct: 483 -IAMEWSQCTVTCGR 496



 Score = 29.3 bits (64), Expect = 8.1
 Identities = 11/30 (36%), Positives = 19/30 (63%), Gaps = 2/30 (6%)

Query: 41  WVS--WTRCSSSCGRGVSVRSRRCLRLPGE 68
           W++  W++C+ +CGRG+  R   C+   GE
Sbjct: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGE 511


>gi|110825974 ADAM metallopeptidase with thrombospondin type 1
           motif, 2 isoform 1 preproprotein [Homo sapiens]
          Length = 1211

 Score =  132 bits (333), Expect = 5e-31
 Identities = 88/262 (33%), Positives = 131/262 (50%), Gaps = 13/262 (4%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRCLR---LPGEEPCWGDSHEYRLCQLPDCPPGAVP 92
           G W  W  +  CS +CG GV  R+R+C       G   C G +++++LC   DCP     
Sbjct: 562 GSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLAD 621

Query: 93  FRDLQCALYNGRPVLGTQKTYQWVPFH--GAPNQCDLNCLAEGHAFYHSFGRVL-DGTAC 149
           FR+ QC  ++     G  + + W+P     A  +C L C +       S  R++ DGT C
Sbjct: 622 FREEQCRQWDLYFEHGDAQ-HHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRC 680

Query: 150 S-PGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYWN 208
           S   A  +CV G C   GCDG++GS   ED+CG CGG N  C  V+  F  +    GY  
Sbjct: 681 SYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIK 740

Query: 209 VTLIPEGARHIRVEH--RSRNHLALMGGD-GRYVLN-GHWVVSPPGTYEAAGTHVVYTRD 264
           +  IP GARH+ ++    + +HLA+   + G+++LN  + V +   T+ A G    Y RD
Sbjct: 741 MFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEY-RD 799

Query: 265 TGPQETLQAAGPTSHDLLLQVL 286
              +ETLQ  GP    + + V+
Sbjct: 800 EDGRETLQTMGPLHGTITVLVI 821



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 14/27 (51%), Positives = 19/27 (70%), Gaps = 3/27 (11%)

Query: 41  WVS--WTRCSSSCGR-GVSVRSRRCLR 64
           WV+  W  CS +CGR G+ VRS RC++
Sbjct: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQ 944


>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif,
           3 proprotein [Homo sapiens]
          Length = 1205

 Score =  125 bits (315), Expect = 6e-29
 Identities = 86/265 (32%), Positives = 124/265 (46%), Gaps = 14/265 (5%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRC---LRLPGEEPCWGDSHEYRLCQLPDCPPGAVP 92
           G W  W  +  CS +CG GV  R+R+C   + + G + C G + EY+LC   +C      
Sbjct: 552 GNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFED 611

Query: 93  FRDLQCALYNGRPVLGTQKTYQWVPF-HGAPNQ-CDLNCLAE--GHAFYHSFGRVLDGTA 148
           FR  QC   N        K + W+P+ H  P + C L C ++  G   Y     V DGT 
Sbjct: 612 FRAQQCQQRNSHFEYQNTK-HHWLPYEHPDPKKRCHLYCQSKETGDVAYMK-QLVHDGTH 669

Query: 149 CS-PGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYW 207
           CS      +CV G C+  GCD  +GS  +ED+CG CGG N  C  V+  F       GY 
Sbjct: 670 CSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYL 729

Query: 208 NVTLIPEGARHIRV--EHRSRNHLALMG-GDGRYVLNGHWVVSPPGTYEAAGTHVVYTRD 264
            +  IP GARH+ +  +  S + LA+     G Y+LNG    +   T+   G    Y  +
Sbjct: 730 KMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIE 789

Query: 265 TGPQETLQAAGPTSHDLLLQVLLQE 289
               E+L   GP    +++ ++ QE
Sbjct: 790 -DDIESLHTDGPLHDPVIVLIIPQE 813



 Score = 36.6 bits (83), Expect = 0.051
 Identities = 20/53 (37%), Positives = 25/53 (47%), Gaps = 5/53 (9%)

Query: 35   PGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHE-YRLCQLPDC 86
            P +W     W+ CS +CG G  VR   C      + C G+  E  R CQLP C
Sbjct: 967  PAQWKTG-PWSECSVTCGEGTEVRQVLC---RAGDHCDGEKPESVRACQLPPC 1015


>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
           14 isoform 2 preproprotein [Homo sapiens]
          Length = 1223

 Score =  119 bits (297), Expect = 8e-27
 Identities = 83/261 (31%), Positives = 119/261 (45%), Gaps = 12/261 (4%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLP---GEEPCWGDSHEYRLCQLPDCPPGAVP 92
           G W+ W  +  CS SCG GV  RSR C       G   C G   EY++C   +CP     
Sbjct: 553 GGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYED 612

Query: 93  FRDLQCALYNGRPVLGTQKTYQWVPFHGAPN--QCDLNCLAEGHAFYHSFGRVL-DGTAC 149
           FR  QCA  N   V    K + WVP+    +  +C+L C +          +V+ DGT C
Sbjct: 613 FRAQQCAKRNSYYVHQNAK-HSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRC 671

Query: 150 S-PGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYWN 208
           S      VC  G C+  GCD  +GS   +D+CG CGG N  C  V+     A   AG   
Sbjct: 672 SYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALK 731

Query: 209 VTLIPEGARHIRVE--HRSRNHLALMGG-DGRYVLNGHWVVSPPGTYEAAGTHVVYTRDT 265
           +  IP GARHI++E   +S + + +     G ++LN     +   T+ A G       + 
Sbjct: 732 LVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVED 791

Query: 266 GPQETLQAAGPTSHDLLLQVL 286
             +E+L+ +GP    + +  L
Sbjct: 792 A-KESLKTSGPLPEAIAILAL 811



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 17/54 (31%), Positives = 27/54 (50%), Gaps = 3/54 (5%)

Query: 35   PGEWTPWVSWTRCSSSCGRGVSVRSRRC-LRLPGEEPCWGDSHE-YRLCQLPDC 86
            P +W    +W++CS++CG G+  R   C         C GD  +  ++C LP C
Sbjct: 969  PAQWRLG-AWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPAC 1021



 Score = 30.0 bits (66), Expect = 4.7
 Identities = 23/67 (34%), Positives = 29/67 (43%), Gaps = 12/67 (17%)

Query: 33  QGPGEWTPWVS--WTRCSSSCGR-GVSVRSRRCL--------RLPGEEPCWGDSHEYRL- 80
           Q P     WV+  W  CS SCG+ GV  R  +CL        ++   + C GD  E R  
Sbjct: 903 QHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRP 962

Query: 81  CQLPDCP 87
           C    CP
Sbjct: 963 CLRVPCP 969


>gi|110611167 ADAM metallopeptidase with thrombospondin type 1
           motif, 14 isoform 1 preproprotein [Homo sapiens]
          Length = 1226

 Score =  119 bits (297), Expect = 8e-27
 Identities = 83/261 (31%), Positives = 119/261 (45%), Gaps = 12/261 (4%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLP---GEEPCWGDSHEYRLCQLPDCPPGAVP 92
           G W+ W  +  CS SCG GV  RSR C       G   C G   EY++C   +CP     
Sbjct: 556 GGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYED 615

Query: 93  FRDLQCALYNGRPVLGTQKTYQWVPFHGAPN--QCDLNCLAEGHAFYHSFGRVL-DGTAC 149
           FR  QCA  N   V    K + WVP+    +  +C+L C +          +V+ DGT C
Sbjct: 616 FRAQQCAKRNSYYVHQNAK-HSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRC 674

Query: 150 S-PGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYWN 208
           S      VC  G C+  GCD  +GS   +D+CG CGG N  C  V+     A   AG   
Sbjct: 675 SYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALK 734

Query: 209 VTLIPEGARHIRVE--HRSRNHLALMGG-DGRYVLNGHWVVSPPGTYEAAGTHVVYTRDT 265
           +  IP GARHI++E   +S + + +     G ++LN     +   T+ A G       + 
Sbjct: 735 LVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVED 794

Query: 266 GPQETLQAAGPTSHDLLLQVL 286
             +E+L+ +GP    + +  L
Sbjct: 795 A-KESLKTSGPLPEAIAILAL 814



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 17/54 (31%), Positives = 27/54 (50%), Gaps = 3/54 (5%)

Query: 35   PGEWTPWVSWTRCSSSCGRGVSVRSRRC-LRLPGEEPCWGDSHE-YRLCQLPDC 86
            P +W    +W++CS++CG G+  R   C         C GD  +  ++C LP C
Sbjct: 972  PAQWRLG-AWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPAC 1024



 Score = 30.0 bits (66), Expect = 4.7
 Identities = 23/67 (34%), Positives = 29/67 (43%), Gaps = 12/67 (17%)

Query: 33  QGPGEWTPWVS--WTRCSSSCGR-GVSVRSRRCL--------RLPGEEPCWGDSHEYRL- 80
           Q P     WV+  W  CS SCG+ GV  R  +CL        ++   + C GD  E R  
Sbjct: 906 QHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRP 965

Query: 81  CQLPDCP 87
           C    CP
Sbjct: 966 CLRVPCP 972


>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
           13 isoform 3 preproprotein [Homo sapiens]
          Length = 1340

 Score =  115 bits (288), Expect = 9e-26
 Identities = 107/361 (29%), Positives = 142/361 (39%), Gaps = 45/361 (12%)

Query: 36  GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLP---GEEPCWGDSHEYRLCQLPDCPPGAVP 92
           G W+ W   + CS SCG GV  R R+C       G   C G   +  +C    C    + 
Sbjct: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLE 413

Query: 93  FRDLQCALYNGRPVL---GTQKTYQW---VPFHGAPNQCDLNCLAEGHAFYHSFG-RVLD 145
           F   QCA  +G+P+    G    Y W   VP       C   C A G +F    G   LD
Sbjct: 414 FMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLD 473

Query: 146 GTACSP------GAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRD 199
           GT C P      G   +CV+G C + GCDG + S  + DRC  CGG N +C   +  F  
Sbjct: 474 GTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTA 533

Query: 200 AGAFAGYWNVTLIPEGARHIRVEHRSR-NHLALMGGDGRYVLNGHWVVSPPGTYEA---- 254
             A      +T+ P         HR    HLA+  G GRYV+ G   +SP  TY +    
Sbjct: 534 GRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG-GRYVVAGKMSISPNTTYPSLLED 592

Query: 255 --AGTHVVYTRDTGPQ-ETLQAAGPTSHDLLLQVLLQE-------PNPGIEFEFWLPRER 304
                 V  T D  P+ E ++  GP   D  +QV  +          P I F ++ P+ R
Sbjct: 593 GRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPR 652

Query: 305 YSPFQARVQ---------ALGWP----LRQPQPRGVEPQPPAAPAVTPAQTPTLAPDPCP 351
            +   A V+          L W     L Q +   VE          PA       +PCP
Sbjct: 653 QAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCP 712

Query: 352 P 352
           P
Sbjct: 713 P 713



 Score = 31.2 bits (69), Expect = 2.1
 Identities = 28/95 (29%), Positives = 38/95 (40%), Gaps = 15/95 (15%)

Query: 21  WALLNCGLGVSAQGPGEWTPWVSWTRCSSSCGRGVSVRSRRC----LRLPGEEPCWG--- 73
           W  +  G    AQ    WTP      CS SCGRG+      C    LR+P +E   G   
Sbjct: 853 WGSIRTG----AQAAHVWTPAAG--SCSVSCGRGLMELRFLCMDSALRVPVQEELCGLAS 906

Query: 74  -DSHEYRLCQLPDCPPGAVPFRDLQCALYNGRPVL 107
                  +CQ   C P    ++   C++  GR V+
Sbjct: 907 KPGSRREVCQAVPC-PARWQYKLAACSVSCGRGVV 940



 Score = 31.2 bits (69), Expect = 2.1
 Identities = 20/53 (37%), Positives = 21/53 (39%), Gaps = 11/53 (20%)

Query: 47  CSSSCGRGVSVRSRRCLRLPGEE---------PCWG--DSHEYRLCQLPDCPP 88
           CS SCGRGV  R   C R  GE+          C G         C L  CPP
Sbjct: 931 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPP 983



 Score = 29.6 bits (65), Expect = 6.2
 Identities = 23/86 (26%), Positives = 31/86 (36%), Gaps = 22/86 (25%)

Query: 43   SWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEY-------RLCQLPDC--------- 86
            +W  CS SCG G+  R   CL    + P   D  ++       R C    C         
Sbjct: 1049 TWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQ 1108

Query: 87   ---PPGAVPFR---DLQCALYNGRPV 106
               P G +  R      CA+  GRP+
Sbjct: 1109 HLEPTGTIDMRGPGQADCAVAIGRPL 1134


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.140    0.484 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,232,198
Number of Sequences: 37866
Number of extensions: 1396095
Number of successful extensions: 9579
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 114
Number of HSP's successfully gapped in prelim test: 180
Number of HSP's that attempted gapping in prelim test: 7990
Number of HSP's gapped (non-prelim): 1468
length of query: 471
length of database: 18,247,518
effective HSP length: 106
effective length of query: 365
effective length of database: 14,233,722
effective search space: 5195308530
effective search space used: 5195308530
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.