Search of human proteins with 226371733

Search of human proteins with 226371733

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|226371733 hydroxysteroid dehydrogenase like 1 isoform b
[Homo sapiens]
         (275 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|226371733 hydroxysteroid dehydrogenase like 1 isoform b [Homo...   557   e-159
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo...   496   e-140
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]   154   1e-37
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]            97   1e-20
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...    60   2e-09
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap...    57   1e-08
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...    55   9e-08
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ...    49   4e-06
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...    49   4e-06
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B...    48   1e-05
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    46   4e-05
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]     46   4e-05
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]      45   9e-05
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]       45   9e-05
gi|40254992 carbonic reductase 4 [Homo sapiens]                        44   1e-04
gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Hom...    44   2e-04
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]         40   0.002
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]              40   0.002
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          40   0.002
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    39   0.004
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    39   0.004
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    39   0.004
gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo...    39   0.004
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    39   0.004
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    39   0.005
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]     38   0.008
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]     38   0.008
gi|166795268 retinol dehydrogenase 11 [Homo sapiens]                   38   0.008
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]           38   0.011
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    37   0.024

>gi|226371733 hydroxysteroid dehydrogenase like 1 isoform b [Homo
           sapiens]
          Length = 275

 Score =  557 bits (1436), Expect = e-159
 Identities = 275/275 (100%), Positives = 275/275 (100%)

Query: 1   MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRA 60
           MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRA
Sbjct: 1   MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRA 60

Query: 61  DLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQYFTQLSEDKLWDIIN 120
           DLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQYFTQLSEDKLWDIIN
Sbjct: 61  DLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQYFTQLSEDKLWDIIN 120

Query: 121 VNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYE 180
           VNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYE
Sbjct: 121 VNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYE 180

Query: 181 YASKGIFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSH 240
           YASKGIFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSH
Sbjct: 181 YASKGIFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSH 240

Query: 241 SIQFLFAQYMPEWLWVWGANILNRSLRKEALSCTA 275
           SIQFLFAQYMPEWLWVWGANILNRSLRKEALSCTA
Sbjct: 241 SIQFLFAQYMPEWLWVWGANILNRSLRKEALSCTA 275


>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
           sapiens]
          Length = 330

 Score =  496 bits (1276), Expect = e-140
 Identities = 262/330 (79%), Positives = 265/330 (80%), Gaps = 55/330 (16%)

Query: 1   MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRA 60
           MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRA
Sbjct: 1   MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRA 60

Query: 61  DLIKQYGRWAVVSGATDGIGKAY------------------------AEELA-------- 88
           DLIKQYGRWAVVSGATDGIGKAY                        A+++A        
Sbjct: 61  DLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETD 120

Query: 89  ------SRGLNIILISRNEEK-----------------LQYFTQLSEDKLWDIINVNIAA 125
                 S G  I L  R   K                  QYFTQLSEDKLWDIINVNIAA
Sbjct: 121 IIVADFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAA 180

Query: 126 ASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKG 185
           ASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKG
Sbjct: 181 ASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKG 240

Query: 186 IFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFL 245
           IFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFL
Sbjct: 241 IFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFL 300

Query: 246 FAQYMPEWLWVWGANILNRSLRKEALSCTA 275
           FAQYMPEWLWVWGANILNRSLRKEALSCTA
Sbjct: 301 FAQYMPEWLWVWGANILNRSLRKEALSCTA 330


>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
          Length = 312

 Score =  154 bits (388), Expect = 1e-37
 Identities = 97/303 (32%), Positives = 153/303 (50%), Gaps = 63/303 (20%)

Query: 28  VGAWYTARKSITVICDFYSLIRLHFIPRLGSRADLIKQYGRWAVVSGATDGIGKAYAEEL 87
           VGA   A  ++ +    ++ +R+  +   G+ A +    G WAVV+G+TDGIGK+YAEEL
Sbjct: 14  VGAGTVAYLALRISYSLFTALRVWGV---GNEAGVGPGLGEWAVVTGSTDGIGKSYAEEL 70

Query: 88  ASRGLNIILISRNE-----------EKLQYFTQ-----LSEDKLWD-------------- 117
           A  G+ ++LISR++           EK +  T+      + + ++D              
Sbjct: 71  AKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKTGLAGLEIGIL 130

Query: 118 --------------------------IINVNIAAASLMVHVVLPGMVERKKGAIVTISSG 151
                                     +IN+NI +   M  +VLPGMVER KGAI+ ISSG
Sbjct: 131 VNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSG 190

Query: 152 SCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVATSMTAPSNFLHRCS 211
           S   P P L  +SA+K ++D FS+ L  EY SKG+FVQS++P++VAT +      + + +
Sbjct: 191 SGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAK----IRKPT 246

Query: 212 WLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFAQYMPEWLWVWGANILNRSLRKEAL 271
              PSP+ +   A+ T+G+  RT GY  H++       +P W+++     +N+S R   L
Sbjct: 247 LDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIISNLPSWIYLKIVMNMNKSTRAHYL 306

Query: 272 SCT 274
             T
Sbjct: 307 KKT 309


>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
          Length = 310

 Score = 97.4 bits (241), Expect = 1e-20
 Identities = 70/251 (27%), Positives = 113/251 (45%), Gaps = 58/251 (23%)

Query: 63  IKQYGRWAVVSGATDGIGKAYAEELASRGL-------------------------NIILI 97
           ++  G+WAV++GA DGIGKAY+ ELA RGL                         ++ +I
Sbjct: 44  LRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKII 103

Query: 98  SRNEEKLQYFTQLSE-----------------------------DKLWDIINVNIAAASL 128
             +  K   +  + E                             D++  +I+ NI +   
Sbjct: 104 QADFTKDDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVK 163

Query: 129 MVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFV 188
           M  ++L  M  R+KG I+ ISSG    P P  + +SASKA++  FS+ALQ EY +K + +
Sbjct: 164 MTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVII 223

Query: 189 QSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFAQ 248
           Q L P+ V+T+MT   N     + +  +   +   +++ + I   T G  +H I   F  
Sbjct: 224 QVLTPYAVSTAMTKYLN----TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLS 279

Query: 249 YMPEWLWVWGA 259
            +P W +  GA
Sbjct: 280 LIPAWAFYSGA 290


>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 57/208 (27%), Positives = 99/208 (47%), Gaps = 21/208 (10%)

Query: 62  LIKQYGRWAVVSGATDGIGKAY-AEELASR------GLNIILISRNEEKLQYFTQLSEDK 114
           + K  G    V+G    +GKA   E+L ++      G++ ++ S     L   T  + ++
Sbjct: 77  MAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQ 136

Query: 115 LWD-IINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHF 173
           +WD I++VN+ + +L++  +LP M E ++GA++ +SS +   P   L  ++ SK  L   
Sbjct: 137 IWDKILSVNVKSPALLLSQLLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGL 195

Query: 174 SRALQYEYASKGIFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKR 233
           +R L  E A K I V  ++P  + T     S   H    L  + K   HH +  +G S+ 
Sbjct: 196 TRTLALELAPKDIRVNCVVPGIIKTDF---SKVFHGNESLWKNFK--EHHQLQRIGESED 250

Query: 234 TTGYWSHSIQFLFAQYMPEWLWVWGANI 261
             G     + FL +   P+  +V G NI
Sbjct: 251 CAGI----VSFLCS---PDASYVNGENI 271


>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
           sapiens]
          Length = 300

 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 41/148 (27%), Positives = 76/148 (51%), Gaps = 9/148 (6%)

Query: 62  LIKQYGRWAVVSGATDGIGKAY-AEELASR------GLNIILISRNEEKLQYFTQLSEDK 114
           + K  G    V+G    +GKA   E+L ++      G++ ++ S     L   T  + ++
Sbjct: 77  MAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQ 136

Query: 115 LWD-IINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHF 173
           +WD I++VN+ + +L++  +LP M E ++GA++ +SS +   P   L  ++ SK  L   
Sbjct: 137 IWDKILSVNVKSPALLLSQLLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGL 195

Query: 174 SRALQYEYASKGIFVQSLIPFYVATSMT 201
           +R L  E A K I V  ++P  + T  +
Sbjct: 196 TRTLALELAPKDIRVNCVVPGIIKTDFS 223


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score = 54.7 bits (130), Expect = 9e-08
 Identities = 41/144 (28%), Positives = 73/144 (50%), Gaps = 10/144 (6%)

Query: 67  GRWAVVSGATDGIGKAY-AEELASRGLNI-----ILISRNEEKLQYFTQLSE--DKLWD- 117
           G    V+G    +GKA   E L +  + +     IL+S N     +F  + +  +++WD 
Sbjct: 78  GEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVS-NAAVNPFFGSIMDVTEEVWDK 136

Query: 118 IINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRAL 177
            +++N+ A +LM   V+P M +R  G++V +SS +   P+P  + ++ SK  L   ++ L
Sbjct: 137 TLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTL 196

Query: 178 QYEYASKGIFVQSLIPFYVATSMT 201
             E A + I V  L P  + TS +
Sbjct: 197 AIELAPRNIRVNCLAPGLIKTSFS 220


>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
           [Homo sapiens]
          Length = 281

 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 31/107 (28%), Positives = 59/107 (55%), Gaps = 2/107 (1%)

Query: 97  ISRNEEKLQYFTQL-SEDKLWDI-INVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCC 154
           I+ ++  L +FT L + ++ WD  +++N  A +LM+  V+P M +R  G++  ++S +  
Sbjct: 117 ITNSKRGLFWFTLLQTAEEAWDRNLDINGKALALMIKAVVPEMEKRGGGSVGFLASVAAF 176

Query: 155 KPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVATSMT 201
           +P P  + ++ SK  L   ++ L  E A + I V  L P  + TS +
Sbjct: 177 RPLPGFSPYNVSKTALLGLNKTLAIELAPRNIRVNCLAPGLIKTSFS 223


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 39/134 (29%), Positives = 67/134 (50%), Gaps = 10/134 (7%)

Query: 67  GRWAVVSGATDGIGKAY-AEELASRGLNI-----ILISRNEEKLQYFTQLSE--DKLWD- 117
           G    V+G    +GKA   E L +  + +     IL+S N     +F  L +  +++WD 
Sbjct: 78  GEGLSVTGTVCHVGKAEDRERLVAMAVKLHGGIDILVS-NAAVNPFFGSLMDVTEEVWDK 136

Query: 118 IINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRAL 177
            +++N+ A +LM   V+P M +R  G++V +SS +   P+P  + ++ SK  L   +  L
Sbjct: 137 TLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTL 196

Query: 178 QYEYASKGIFVQSL 191
             E A + I V  L
Sbjct: 197 AIELAPRNIRVNCL 210


>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
           [Homo sapiens]
          Length = 264

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 46/184 (25%), Positives = 71/184 (38%), Gaps = 25/184 (13%)

Query: 38  ITVICDFYSLIRLHFIPRLGSRADLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILI 97
           IT+I  +   +   FIP+           G   +++GA  GIG+    E A R   ++L 
Sbjct: 12  ITIIYSYLESLVKFFIPQRRKSVA-----GEIVLITGAGHGIGRQTTYEFAKRQSILVLW 66

Query: 98  SRNEEKLQY-----------------FTQLSEDKLWDIINVNIAAASLMVHVVLPGMVER 140
             N+ K +                       ++++     VNI     +   +LP M+ER
Sbjct: 67  DINKVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMER 126

Query: 141 KKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYE---YASKGIFVQSLIPFYVA 197
             G IVT++S    +  P L  + +SK     F R L  E       GI    L P +V 
Sbjct: 127 NHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVN 186

Query: 198 TSMT 201
           T  T
Sbjct: 187 TGFT 190


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 47/204 (23%), Positives = 85/204 (41%), Gaps = 16/204 (7%)

Query: 73  SGATDGIGKAYAEELASRGLNIILISRNEEKLQYFTQLSEDKLWDIINVNIAAASLMVHV 132
           +G+ +   KA  +E     ++I++ +    +       S D    +I +N      +   
Sbjct: 115 TGSHEAATKAVLQEFGR--IDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKC 172

Query: 133 VLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYAS-KGIFVQSL 191
           VLP M+ERK+G IVT++S       P    + ASK  L  F   L+ E A+  GI V ++
Sbjct: 173 VLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNI 232

Query: 192 IPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVST-------LGISKRTTGYWSHSIQF 244
            P  V +++   ++     +  + +    +H   ++       + ++      W     F
Sbjct: 233 CPGPVQSNI-VENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPF 291

Query: 245 LFA----QYMPEWLWVWGANILNR 264
           L      QYMP W W W  N + +
Sbjct: 292 LLVTYLWQYMPTWAW-WITNKMGK 314



 Score = 29.3 bits (64), Expect = 3.9
 Identities = 12/34 (35%), Positives = 24/34 (70%)

Query: 72  VSGATDGIGKAYAEELASRGLNIILISRNEEKLQ 105
           V+GA+ GIG+  A +L+  G++++L +R   +L+
Sbjct: 55  VTGASSGIGEELAYQLSKLGVSLVLSARRVHELE 88


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 41/177 (23%), Positives = 69/177 (38%), Gaps = 45/177 (25%)

Query: 67  GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQYFTQLS--------------- 111
           G+  +++ A  GIG+A A   A  G  +I    NE KLQ   +                 
Sbjct: 6   GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVTKKKQI 65

Query: 112 ----------------------------EDKLWDI-INVNIAAASLMVHVVLPGMVERKK 142
                                       E+K WD  +N+N+ +  LM+   LP M+ +K 
Sbjct: 66  DQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKMLAQKS 125

Query: 143 GAIVTISS-GSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVAT 198
           G I+ +SS  S  K       +S +KA +   ++++  ++  +GI    + P  V T
Sbjct: 126 GNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTVDT 182


>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 48/200 (24%), Positives = 81/200 (40%), Gaps = 59/200 (29%)

Query: 67  GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQ---------------YFTQLS 111
           G+  +V+GA+ GIG+  A  LA  G ++++ +R++E LQ               Y     
Sbjct: 34  GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTM 93

Query: 112 EDKLW---------------------------------DI------INVNIAAASLMVHV 132
           ED  +                                 DI      + VN  +  ++   
Sbjct: 94  EDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA 153

Query: 133 VLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLI 192
            LP M+++  G+IV +SS +     P +AA+SASK  LD F  +++ EY+   + V   +
Sbjct: 154 ALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITL 212

Query: 193 PFY----VATSMTAPSNFLH 208
                    T+M A S  +H
Sbjct: 213 CVLGLIDTETAMKAVSGIVH 232


>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 48/200 (24%), Positives = 81/200 (40%), Gaps = 59/200 (29%)

Query: 67  GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQ---------------YFTQLS 111
           G+  +V+GA+ GIG+  A  LA  G ++++ +R++E LQ               Y     
Sbjct: 34  GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTM 93

Query: 112 EDKLW---------------------------------DI------INVNIAAASLMVHV 132
           ED  +                                 DI      + VN  +  ++   
Sbjct: 94  EDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA 153

Query: 133 VLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLI 192
            LP M+++  G+IV +SS +     P +AA+SASK  LD F  +++ EY+   + V   +
Sbjct: 154 ALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITL 212

Query: 193 PFY----VATSMTAPSNFLH 208
                    T+M A S  +H
Sbjct: 213 CVLGLIDTETAMKAVSGIVH 232


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 28/83 (33%), Positives = 43/83 (51%)

Query: 119 INVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQ 178
           ++ N+  + L     +  M++++ G+IV + S    K     + +SASK  L  FSRAL 
Sbjct: 104 LHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALA 163

Query: 179 YEYASKGIFVQSLIPFYVATSMT 201
            E A K I V  + P +V T MT
Sbjct: 164 KEVARKKIRVNVVAPGFVHTDMT 186


>gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Homo
           sapiens]
          Length = 377

 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 33/82 (40%), Positives = 46/82 (56%), Gaps = 10/82 (12%)

Query: 22  MEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRADLIKQYGRWAVVSGATDGIGK 81
           MEAL L+GA       + V   +Y+L++    P  G   +L    GR AVV+GA  GIGK
Sbjct: 1   MEAL-LLGAGLLLGAYVLV---YYNLVKA---PPCGGMGNL---RGRTAVVTGANSGIGK 50

Query: 82  AYAEELASRGLNIILISRNEEK 103
             A ELA RG  ++L  R++E+
Sbjct: 51  MTALELARRGARVVLACRSQER 72


>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
          Length = 331

 Score = 40.0 bits (92), Expect = 0.002
 Identities = 21/39 (53%), Positives = 26/39 (66%)

Query: 67  GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQ 105
           G+  +V+GA  GIGK  A ELA RG NIIL  R+ EK +
Sbjct: 38  GKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCE 76


>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
          Length = 244

 Score = 40.0 bits (92), Expect = 0.002
 Identities = 38/180 (21%), Positives = 68/180 (37%), Gaps = 46/180 (25%)

Query: 67  GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKL---------------------- 104
           GR  +V+GA  GIG+   + L + G  ++ +SR +  L                      
Sbjct: 7   GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEA 66

Query: 105 -----------------------QYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERK 141
                                  Q F +++++       VN+ A   +  +V  G++ R 
Sbjct: 67  TERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARG 126

Query: 142 -KGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVATSM 200
             GAIV +SS    +     + + ++K  LD  ++ +  E     I V ++ P  V TSM
Sbjct: 127 VPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSM 186


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 40.0 bits (92), Expect = 0.002
 Identities = 28/89 (31%), Positives = 43/89 (48%)

Query: 110 LSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAY 169
           LS   + ++ + N   A  +V  VLPGM  R++G IV ISS    +       ++ASK  
Sbjct: 102 LSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFA 161

Query: 170 LDHFSRALQYEYASKGIFVQSLIPFYVAT 198
           L+ F  +L  +     IF+  + P  V T
Sbjct: 162 LEGFFESLAIQLLQFNIFISLVEPGPVVT 190


>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 39.3 bits (90), Expect = 0.004
 Identities = 30/104 (28%), Positives = 49/104 (47%), Gaps = 11/104 (10%)

Query: 104 LQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAF 163
           L+ + Q++E  LW  +         M    LP ++ R KG +V ISS       P  + +
Sbjct: 158 LETYKQVAEVNLWGTVR--------MTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPY 208

Query: 164 SASKAYLDHFSRALQYEYASKGIFVQSLIP--FYVATSMTAPSN 205
             +K  ++ FS  L+YE    G+ V  + P  F  ATS+ +P +
Sbjct: 209 CITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPES 252


>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 39.3 bits (90), Expect = 0.004
 Identities = 30/104 (28%), Positives = 49/104 (47%), Gaps = 11/104 (10%)

Query: 104 LQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAF 163
           L+ + Q++E  LW  +         M    LP ++ R KG +V ISS       P  + +
Sbjct: 158 LETYKQVAEVNLWGTVR--------MTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPY 208

Query: 164 SASKAYLDHFSRALQYEYASKGIFVQSLIP--FYVATSMTAPSN 205
             +K  ++ FS  L+YE    G+ V  + P  F  ATS+ +P +
Sbjct: 209 CITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPES 252


>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 39.3 bits (90), Expect = 0.004
 Identities = 30/104 (28%), Positives = 49/104 (47%), Gaps = 11/104 (10%)

Query: 104 LQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAF 163
           L+ + Q++E  LW  +         M    LP ++ R KG +V ISS       P  + +
Sbjct: 158 LETYKQVAEVNLWGTVR--------MTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPY 208

Query: 164 SASKAYLDHFSRALQYEYASKGIFVQSLIP--FYVATSMTAPSN 205
             +K  ++ FS  L+YE    G+ V  + P  F  ATS+ +P +
Sbjct: 209 CITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPES 252


>gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo
           sapiens]
          Length = 330

 Score = 39.3 bits (90), Expect = 0.004
 Identities = 20/51 (39%), Positives = 33/51 (64%), Gaps = 1/51 (1%)

Query: 68  RWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKL-QYFTQLSEDKLWD 117
           R A+V+G TDGIG + A+ LA  G+++I+   N+ K  Q  +++ E+ L D
Sbjct: 44  RVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLND 94


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 39.3 bits (90), Expect = 0.004
 Identities = 28/93 (30%), Positives = 41/93 (44%), Gaps = 3/93 (3%)

Query: 112 EDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLD 171
           ++++     VNI     +   +LP M+ER  G IVT++S    +  P L  + +SK    
Sbjct: 134 DEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAV 193

Query: 172 HFSRALQYE---YASKGIFVQSLIPFYVATSMT 201
            F R L  E       GI    L P +V T  T
Sbjct: 194 GFHRGLTSELQALGKTGIKTSCLCPVFVNTGFT 226


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 38.9 bits (89), Expect = 0.005
 Identities = 42/151 (27%), Positives = 66/151 (43%), Gaps = 11/151 (7%)

Query: 58  SRADLIKQYGRWAVVSGATDG--IGKAYAEELASRGLNIILISRNEEKLQYF-----TQL 110
           S A  ++ +  + V    TD   I  A AE L   G   IL+  N   + Y      T +
Sbjct: 99  SHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILV--NNAGISYRGTIMDTTV 156

Query: 111 SEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYL 170
             DK   ++  N      +   +LP M++R++G IV ISS       P  +A++ASK   
Sbjct: 157 DVDKR--VMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHAT 214

Query: 171 DHFSRALQYEYASKGIFVQSLIPFYVATSMT 201
             F   L+ E     I V  + P Y+ T+++
Sbjct: 215 QAFFDCLRAEMEQYEIEVTVISPGYIHTNLS 245



 Score = 29.6 bits (65), Expect = 3.0
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 71  VVSGATDGIGKAYAEELASRGLNIILISRNEEKLQ 105
           V++GAT G+GK  A+   + G  ++L  RN   L+
Sbjct: 56  VITGATSGLGKECAKVFYAAGAKLVLCGRNGGALE 90


>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
          Length = 387

 Score = 38.1 bits (87), Expect = 0.008
 Identities = 25/85 (29%), Positives = 43/85 (50%), Gaps = 1/85 (1%)

Query: 121 VNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYE 180
           VN      +    LP ++ + KG +V +SS     P  +LA++ +SKA +  FS  ++ E
Sbjct: 191 VNFFGTVEVTKTFLP-LLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLE 249

Query: 181 YASKGIFVQSLIPFYVATSMTAPSN 205
            +  GI V S+ P    T++   S+
Sbjct: 250 LSKWGIKVASIQPGGFLTNIAGTSD 274


>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
          Length = 303

 Score = 38.1 bits (87), Expect = 0.008
 Identities = 17/39 (43%), Positives = 26/39 (66%)

Query: 67  GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQ 105
           G+ A+V+G   GIGKA  +EL   G N+++ SR  E+L+
Sbjct: 18  GQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLK 56


>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
          Length = 318

 Score = 38.1 bits (87), Expect = 0.008
 Identities = 19/37 (51%), Positives = 24/37 (64%)

Query: 67  GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEK 103
           G+  VV+GA  GIGK  A+ELA RG  + L  R+ EK
Sbjct: 41  GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEK 77


>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score = 37.7 bits (86), Expect = 0.011
 Identities = 30/130 (23%), Positives = 59/130 (45%), Gaps = 3/130 (2%)

Query: 89  SRGLNIILISRNEEKLQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERK-KGAIVT 147
           SR  ++++      + ++   +SED    +I VN+    L+       +V    +G+I+ 
Sbjct: 94  SRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIIN 153

Query: 148 ISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVATSMT--APSN 205
           ISS            ++ASKA +   ++    E    GI   S++P ++AT MT   P  
Sbjct: 154 ISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQK 213

Query: 206 FLHRCSWLVP 215
            + + + ++P
Sbjct: 214 VVDKITEMIP 223


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 36.6 bits (83), Expect = 0.024
 Identities = 18/38 (47%), Positives = 24/38 (63%)

Query: 67  GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKL 104
           G   VV+G + GIGK  A E   +G  I L++RNE+KL
Sbjct: 32  GAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKL 69



 Score = 30.8 bits (68), Expect = 1.3
 Identities = 22/87 (25%), Positives = 37/87 (42%)

Query: 107 FTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSAS 166
           F  L       ++++N   +      V+  M ER+ G IV +SS +         A+SAS
Sbjct: 130 FEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSAS 189

Query: 167 KAYLDHFSRALQYEYASKGIFVQSLIP 193
           K  +   + ALQ E     +++    P
Sbjct: 190 KFAIRGLAEALQMEVKPYNVYITVAYP 216


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.134    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,468,811
Number of Sequences: 37866
Number of extensions: 372284
Number of successful extensions: 1009
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 929
Number of HSP's gapped (non-prelim): 86
length of query: 275
length of database: 18,247,518
effective HSP length: 101
effective length of query: 174
effective length of database: 14,423,052
effective search space: 2509611048
effective search space used: 2509611048
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.