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Search of human proteins with 226342869
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo
sapiens]
(682 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens] 1394 0.0
gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens] 1355 0.0
gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens] 1344 0.0
gi|13375952 TBC1 domain family, member 17 [Homo sapiens] 596 e-170
gi|33563376 TBC1 domain family, member 16 [Homo sapiens] 202 6e-52
gi|54607014 TBC1 domain family, member 25 [Homo sapiens] 179 6e-45
gi|23503283 TBC1 domain family, member 21 [Homo sapiens] 136 6e-32
gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sa... 129 1e-29
gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sa... 129 1e-29
gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa... 125 1e-28
gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa... 125 1e-28
gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap... 125 1e-28
gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap... 125 1e-28
gi|40068063 TBC1 domain family, member 22B [Homo sapiens] 87 4e-17
gi|22507409 TBC1 domain family, member 22A [Homo sapiens] 87 4e-17
gi|190014603 TBC1 domain family, member 13 [Homo sapiens] 81 4e-15
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 67 5e-11
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 67 5e-11
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 67 5e-11
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 65 3e-10
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 65 3e-10
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 64 5e-10
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 60 7e-09
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 59 2e-08
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 58 3e-08
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 57 6e-08
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 57 7e-08
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 55 2e-07
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 55 2e-07
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 55 3e-07
>gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]
Length = 682
Score = 1394 bits (3607), Expect = 0.0
Identities = 682/682 (100%), Positives = 682/682 (100%)
Query: 1 MCPGLYPYSSLLEYGRSMIIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWR 60
MCPGLYPYSSLLEYGRSMIIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWR
Sbjct: 1 MCPGLYPYSSLLEYGRSMIIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWR 60
Query: 61 PLDDALDSSSILYARKDSSSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFKRKPHT 120
PLDDALDSSSILYARKDSSSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFKRKPHT
Sbjct: 61 PLDDALDSSSILYARKDSSSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFKRKPHT 120
Query: 121 NGDAPSHRNGKSKWSFLFSLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKL 180
NGDAPSHRNGKSKWSFLFSLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKL
Sbjct: 121 NGDAPSHRNGKSKWSFLFSLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKL 180
Query: 181 LIESLEKYVVLCESPQDKRTLLVNCQNKSLSQSFENLLDEPAYGLIQKIKKDPYTATMIG 240
LIESLEKYVVLCESPQDKRTLLVNCQNKSLSQSFENLLDEPAYGLIQKIKKDPYTATMIG
Sbjct: 181 LIESLEKYVVLCESPQDKRTLLVNCQNKSLSQSFENLLDEPAYGLIQKIKKDPYTATMIG 240
Query: 241 FSKVTNYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERP 300
FSKVTNYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERP
Sbjct: 241 FSKVTNYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERP 300
Query: 301 VVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTK 360
VVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTK
Sbjct: 301 VVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTK 360
Query: 361 EERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQD 420
EERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQD
Sbjct: 361 EERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQD 420
Query: 421 NPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFE 480
NPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFE
Sbjct: 421 NPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFE 480
Query: 481 EQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLW 540
EQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLW
Sbjct: 481 EQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLW 540
Query: 541 EVMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEA 600
EVMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEA
Sbjct: 541 EVMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEA 600
Query: 601 ISLQMVKCKELPQAVCEILGLQGSEVTTPDSDVGEDENVVMTPCPTSAFQSNALPTLSAS 660
ISLQMVKCKELPQAVCEILGLQGSEVTTPDSDVGEDENVVMTPCPTSAFQSNALPTLSAS
Sbjct: 601 ISLQMVKCKELPQAVCEILGLQGSEVTTPDSDVGEDENVVMTPCPTSAFQSNALPTLSAS 660
Query: 661 GARNDSPTQIPVSSDVCRLTPA 682
GARNDSPTQIPVSSDVCRLTPA
Sbjct: 661 GARNDSPTQIPVSSDVCRLTPA 682
>gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]
Length = 696
Score = 1355 bits (3507), Expect = 0.0
Identities = 664/664 (100%), Positives = 664/664 (100%)
Query: 19 IIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKDS 78
IIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKDS
Sbjct: 33 IIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKDS 92
Query: 79 SSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLF 138
SSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLF
Sbjct: 93 SSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLF 152
Query: 139 SLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESPQDK 198
SLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESPQDK
Sbjct: 153 SLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESPQDK 212
Query: 199 RTLLVNCQNKSLSQSFENLLDEPAYGLIQKIKKDPYTATMIGFSKVTNYIFDSLRGSDPS 258
RTLLVNCQNKSLSQSFENLLDEPAYGLIQKIKKDPYTATMIGFSKVTNYIFDSLRGSDPS
Sbjct: 213 RTLLVNCQNKSLSQSFENLLDEPAYGLIQKIKKDPYTATMIGFSKVTNYIFDSLRGSDPS 272
Query: 259 THQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNID 318
THQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNID
Sbjct: 273 THQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNID 332
Query: 319 SEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMK 378
SEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMK
Sbjct: 333 SEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMK 392
Query: 379 LQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYD 438
LQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYD
Sbjct: 393 LQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYD 452
Query: 439 FDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLR 498
FDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLR
Sbjct: 453 FDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLR 512
Query: 499 LLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCC 558
LLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCC
Sbjct: 513 LLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCC 572
Query: 559 AILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEI 618
AILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEI
Sbjct: 573 AILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEI 632
Query: 619 LGLQGSEVTTPDSDVGEDENVVMTPCPTSAFQSNALPTLSASGARNDSPTQIPVSSDVCR 678
LGLQGSEVTTPDSDVGEDENVVMTPCPTSAFQSNALPTLSASGARNDSPTQIPVSSDVCR
Sbjct: 633 LGLQGSEVTTPDSDVGEDENVVMTPCPTSAFQSNALPTLSASGARNDSPTQIPVSSDVCR 692
Query: 679 LTPA 682
LTPA
Sbjct: 693 LTPA 696
>gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]
Length = 713
Score = 1344 bits (3479), Expect = 0.0
Identities = 664/681 (97%), Positives = 664/681 (97%), Gaps = 17/681 (2%)
Query: 19 IIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKDS 78
IIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKDS
Sbjct: 33 IIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKDS 92
Query: 79 SSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLF 138
SSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLF
Sbjct: 93 SSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLF 152
Query: 139 SLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESPQDK 198
SLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESPQDK
Sbjct: 153 SLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESPQDK 212
Query: 199 RTLLVNCQNKSLSQSFENLLDEPAYGLIQ-----------------KIKKDPYTATMIGF 241
RTLLVNCQNKSLSQSFENLLDEPAYGLIQ KIKKDPYTATMIGF
Sbjct: 213 RTLLVNCQNKSLSQSFENLLDEPAYGLIQAGLLDRRKLLWAIHHWKKIKKDPYTATMIGF 272
Query: 242 SKVTNYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPV 301
SKVTNYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPV
Sbjct: 273 SKVTNYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPV 332
Query: 302 VQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKE 361
VQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKE
Sbjct: 333 VQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKE 392
Query: 362 ERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDN 421
ERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDN
Sbjct: 393 ERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDN 452
Query: 422 PGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEE 481
PGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEE
Sbjct: 453 PGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEE 512
Query: 482 QMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWE 541
QMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWE
Sbjct: 513 QMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWE 572
Query: 542 VMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAI 601
VMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAI
Sbjct: 573 VMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAI 632
Query: 602 SLQMVKCKELPQAVCEILGLQGSEVTTPDSDVGEDENVVMTPCPTSAFQSNALPTLSASG 661
SLQMVKCKELPQAVCEILGLQGSEVTTPDSDVGEDENVVMTPCPTSAFQSNALPTLSASG
Sbjct: 633 SLQMVKCKELPQAVCEILGLQGSEVTTPDSDVGEDENVVMTPCPTSAFQSNALPTLSASG 692
Query: 662 ARNDSPTQIPVSSDVCRLTPA 682
ARNDSPTQIPVSSDVCRLTPA
Sbjct: 693 ARNDSPTQIPVSSDVCRLTPA 713
>gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
Length = 648
Score = 596 bits (1537), Expect = e-170
Identities = 310/608 (50%), Positives = 414/608 (68%), Gaps = 26/608 (4%)
Query: 19 IIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKDS 78
+++E+ GVY+H+S K D+D LI+G++RV+EKD +V++ W P+++A DS+ IL+++KDS
Sbjct: 8 VVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQILFSKKDS 67
Query: 79 SSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFK--RKPHTNGDAPSHRNGKSKWSF 136
S + G YE +W +++TV + T G PS G W+F
Sbjct: 68 SGGDSCASEEEPTFDPG------YEPDWAVISTVRPQPCHSEPTRGAEPSCPQGS--WAF 119
Query: 137 LFSLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESPQ 196
SL +LKSI+++K G+ W+YLV + LPALHFH+G ++ L+ L +Y++L SPQ
Sbjct: 120 SVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQ 179
Query: 197 DKRTLLVNCQNKS-LSQSFENL--LDEPAYGLIQKIKKDPYTATMIGFSKVTNYIFDSLR 253
D R LV + S LS SF +L D+ + ++ + +DPY+ T FS+VTN+ +L+
Sbjct: 180 DSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQ 239
Query: 254 GSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEW 313
P E A SD P + + EPGFEVI+ ++LG RP V+R PV+ EEW
Sbjct: 240 ---------PQPEGA--ASDLPP--PPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEW 286
Query: 314 TKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDE 373
+++ EGR+ V +K IF GGLS +LR++AWKFLLGY W+ T EE ++KTDE
Sbjct: 287 ARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDE 346
Query: 374 YFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMT 433
YFRMKLQWKS+S EQE+RNS L YRSLIE+DV+RTDRTNKFYEG +NPGL LL+DIL+T
Sbjct: 347 YFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLT 406
Query: 434 YCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQL 493
YCMY FDLGYVQGMSDLLSP+LYV++NEVDAFWCF +M+ + NFEE + MK QL +L
Sbjct: 407 YCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRL 466
Query: 494 STLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFH 553
LLR+LD C +L+SQDSG L FCFRWLLI FKREF F D+LRLWEV+WT LP N H
Sbjct: 467 LLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLH 526
Query: 554 LLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQ 613
LL+ CAIL+ E+ +M +G NEILKHINEL+MK+ VED+L +AEA+ Q+ C ELP
Sbjct: 527 LLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPH 586
Query: 614 AVCEILGL 621
V EILGL
Sbjct: 587 NVQEILGL 594
>gi|33563376 TBC1 domain family, member 16 [Homo sapiens]
Length = 767
Score = 202 bits (515), Expect = 6e-52
Identities = 109/319 (34%), Positives = 178/319 (55%), Gaps = 4/319 (1%)
Query: 308 VSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQ 367
+ + W +++ G++ +++ IF GG+ ++R + W FLL Y+ +ST EER L+
Sbjct: 396 LGVSAWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALR 455
Query: 368 KQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILL 427
QK EY ++Q K +S E+ + R+ + ++KDV RTDR N+F+ G+DNP + +
Sbjct: 456 LQKRKEY--SEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESM 513
Query: 428 HDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMK 487
IL+ Y +Y+ +GY QGMSDL++P+L + +E D FWCF M + + M+
Sbjct: 514 RRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDME 573
Query: 488 TQLIQLSTLLRLLDSGFCSYLES--QDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWT 545
QL+ L LLRL F +L S +D + FC RWLL+ FKREF + LR+WE W
Sbjct: 574 KQLLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWA 633
Query: 546 ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQM 605
FHL +C AI+ ++E+ +++L H L+M ++ E +L KA ++ Q
Sbjct: 634 HYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQF 693
Query: 606 VKCKELPQAVCEILGLQGS 624
+P ++ ++ L GS
Sbjct: 694 RLLPRIPCSLHDLCKLCGS 712
>gi|54607014 TBC1 domain family, member 25 [Homo sapiens]
Length = 688
Score = 179 bits (455), Expect = 6e-45
Identities = 95/245 (38%), Positives = 141/245 (57%), Gaps = 6/245 (2%)
Query: 305 REPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERT 364
+ P+S E+ ++ EG++ + ++ I+ GG+ +LRK W++LL +P T ER
Sbjct: 196 KPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERM 255
Query: 365 QLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEG-QDNPG 423
K+K+ EY ++K +W + ++ L RS + KDV RTDR + +Y G +D P
Sbjct: 256 DYMKRKSREYEQLKSEWAQRANPED-----LEFIRSTVLKDVLRTDRAHPYYAGPEDGPH 310
Query: 424 LILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQM 483
L LHD+L TY + + Y QGMSDL SP+L VM++E AF CF M ++ NF
Sbjct: 311 LRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG 370
Query: 484 QGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVM 543
+ M T+ L LLR D F YL+ + L+FC+RWLL+ KREF+F D LR+ EV
Sbjct: 371 RAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVT 430
Query: 544 WTELP 548
W+ LP
Sbjct: 431 WSSLP 435
Score = 33.1 bits (74), Expect = 0.87
Identities = 17/50 (34%), Positives = 25/50 (50%)
Query: 552 FHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAI 601
F L LC AIL + IM +NE+ H + L K + +L +A A+
Sbjct: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666
>gi|23503283 TBC1 domain family, member 21 [Homo sapiens]
Length = 336
Score = 136 bits (343), Expect = 6e-32
Identities = 87/322 (27%), Positives = 164/322 (50%), Gaps = 17/322 (5%)
Query: 301 VVQRREPVSLEEWTKNIDSEGRILNV-DNMKQMIFRGGLSHALRKQAWKFLLGYFPWDST 359
+V+R+ P+ EW D G + D + I GL +R +AWKFL GYF W S+
Sbjct: 20 LVKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHPFVRTEAWKFLTGYFSWQSS 79
Query: 360 KEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQ 419
++ER + + Y + ++ I E + + R+ I +D+ K Y+ +
Sbjct: 80 QDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRNNIARDIQ------KIYD-K 132
Query: 420 DNPGLIL-----LHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQ 474
D G +L L IL+ + + Y QG +++ ++E++ + FW F ++ +
Sbjct: 133 DPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQK 192
Query: 475 MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREF-SF 533
+ + G+ L LSTL+ LD F +L+ + +G + F W F+R F SF
Sbjct: 193 TEHSCVINI-GVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSF 251
Query: 534 LDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVED 593
D+ RLWEV+ T PC NF +L+ ++L+ ++Q++++ G ++IL N L + +D ++
Sbjct: 252 DDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLACNNL-IDLDADE 310
Query: 594 ILCKAEAISLQMVKCKELPQAV 615
++ A + ++++ K++PQ +
Sbjct: 311 LISAACVVYAELIQ-KDVPQTL 331
>gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo
sapiens]
Length = 1006
Score = 129 bits (323), Expect = 1e-29
Identities = 69/197 (35%), Positives = 113/197 (57%), Gaps = 7/197 (3%)
Query: 402 IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 461
I+KDV R DR ++ P L L D++ +Y D+GYVQGM DLL+PLL ++N+
Sbjct: 797 IDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDND 853
Query: 462 VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 520
A+ CF+ M +M QNF M T + +L+++LDS + ++ D + YFC+
Sbjct: 854 QLAYSCFSHLMKRMSQNFPNG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 912
Query: 521 RWLLIRFKREFSFLDILRLWEVMWT--ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEI 578
RW L+ FKRE + D+ +WEV+W + +F L + A++E+ ++ I + + F +I
Sbjct: 913 RWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDI 972
Query: 579 LKHINELSMKIDVEDIL 595
+K NE + D ++IL
Sbjct: 973 IKFFNERAEHHDAQEIL 989
Score = 45.1 bits (105), Expect = 2e-04
Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 313 WTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTD 372
W+K + ++ ++Q ++ GG+ H +RK W FLLG++ + +K+E Q+
Sbjct: 543 WSKYQKDKKNYKELELLRQ-VYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAA 601
Query: 373 EYFRMKLQWKS 383
Y ++ +WK+
Sbjct: 602 RYQQVLAEWKA 612
>gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo
sapiens]
Length = 1051
Score = 129 bits (323), Expect = 1e-29
Identities = 69/197 (35%), Positives = 113/197 (57%), Gaps = 7/197 (3%)
Query: 402 IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 461
I+KDV R DR ++ P L L D++ +Y D+GYVQGM DLL+PLL ++N+
Sbjct: 842 IDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDND 898
Query: 462 VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 520
A+ CF+ M +M QNF M T + +L+++LDS + ++ D + YFC+
Sbjct: 899 QLAYSCFSHLMKRMSQNFPNG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 957
Query: 521 RWLLIRFKREFSFLDILRLWEVMWT--ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEI 578
RW L+ FKRE + D+ +WEV+W + +F L + A++E+ ++ I + + F +I
Sbjct: 958 RWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDI 1017
Query: 579 LKHINELSMKIDVEDIL 595
+K NE + D ++IL
Sbjct: 1018 IKFFNERAEHHDAQEIL 1034
Score = 45.1 bits (105), Expect = 2e-04
Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 313 WTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTD 372
W+K + ++ ++Q ++ GG+ H +RK W FLLG++ + +K+E Q+
Sbjct: 588 WSKYQKDKKNYKELELLRQ-VYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAA 646
Query: 373 EYFRMKLQWKS 383
Y ++ +WK+
Sbjct: 647 RYQQVLAEWKA 657
>gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo
sapiens]
Length = 1032
Score = 125 bits (314), Expect = 1e-28
Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%)
Query: 402 IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 461
IEKDV R DR N +Y N L L +I+ +Y ++GYVQGM DLL+PLL ++++E
Sbjct: 823 IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 879
Query: 462 VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 520
AF CF M +M+QNF M T + +L+++LDS + ++ D + YFC+
Sbjct: 880 ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 938
Query: 521 RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 578
RW L+ FKRE + D+ +WE +W ++ H L + A++E + I+E + F +I
Sbjct: 939 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 998
Query: 579 LKHINELSMKIDVEDIL 595
+K NE++ + + + +L
Sbjct: 999 IKFFNEMAERHNTKQVL 1015
Score = 36.2 bits (82), Expect = 0.10
Identities = 17/58 (29%), Positives = 31/58 (53%)
Query: 331 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQ 388
++I+ GG+ +RK W FLLG++ + T+ ER + + + ++L S S Q
Sbjct: 556 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQ 613
>gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo
sapiens]
Length = 1093
Score = 125 bits (314), Expect = 1e-28
Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%)
Query: 402 IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 461
IEKDV R DR N +Y N L L +I+ +Y ++GYVQGM DLL+PLL ++++E
Sbjct: 884 IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 940
Query: 462 VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 520
AF CF M +M+QNF M T + +L+++LDS + ++ D + YFC+
Sbjct: 941 ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 999
Query: 521 RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 578
RW L+ FKRE + D+ +WE +W ++ H L + A++E + I+E + F +I
Sbjct: 1000 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1059
Query: 579 LKHINELSMKIDVEDIL 595
+K NE++ + + + +L
Sbjct: 1060 IKFFNEMAERHNTKQVL 1076
Score = 40.4 bits (93), Expect = 0.005
Identities = 18/65 (27%), Positives = 39/65 (60%), Gaps = 3/65 (4%)
Query: 331 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQW---KSISQE 387
++I+ GG+ +RK W FLLG++ + T+ ER ++ +Q Y + +W ++I ++
Sbjct: 556 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAEWLGCEAIVRQ 615
Query: 388 QEKRN 392
+E+ +
Sbjct: 616 RERES 620
>gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens]
Length = 1087
Score = 125 bits (314), Expect = 1e-28
Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%)
Query: 402 IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 461
IEKDV R DR N +Y N L L +I+ +Y ++GYVQGM DLL+PLL ++++E
Sbjct: 878 IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 934
Query: 462 VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 520
AF CF M +M+QNF M T + +L+++LDS + ++ D + YFC+
Sbjct: 935 ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 993
Query: 521 RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 578
RW L+ FKRE + D+ +WE +W ++ H L + A++E + I+E + F +I
Sbjct: 994 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1053
Query: 579 LKHINELSMKIDVEDIL 595
+K NE++ + + + +L
Sbjct: 1054 IKFFNEMAERHNTKQVL 1070
Score = 36.2 bits (82), Expect = 0.10
Identities = 17/58 (29%), Positives = 31/58 (53%)
Query: 331 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQ 388
++I+ GG+ +RK W FLLG++ + T+ ER + + + ++L S S Q
Sbjct: 611 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQ 668
>gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens]
Length = 1148
Score = 125 bits (314), Expect = 1e-28
Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%)
Query: 402 IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 461
IEKDV R DR N +Y N L L +I+ +Y ++GYVQGM DLL+PLL ++++E
Sbjct: 939 IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 995
Query: 462 VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 520
AF CF M +M+QNF M T + +L+++LDS + ++ D + YFC+
Sbjct: 996 ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 1054
Query: 521 RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 578
RW L+ FKRE + D+ +WE +W ++ H L + A++E + I+E + F +I
Sbjct: 1055 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1114
Query: 579 LKHINELSMKIDVEDIL 595
+K NE++ + + + +L
Sbjct: 1115 IKFFNEMAERHNTKQVL 1131
Score = 40.4 bits (93), Expect = 0.005
Identities = 18/65 (27%), Positives = 39/65 (60%), Gaps = 3/65 (4%)
Query: 331 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQW---KSISQE 387
++I+ GG+ +RK W FLLG++ + T+ ER ++ +Q Y + +W ++I ++
Sbjct: 611 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAEWLGCEAIVRQ 670
Query: 388 QEKRN 392
+E+ +
Sbjct: 671 RERES 675
>gi|40068063 TBC1 domain family, member 22B [Homo sapiens]
Length = 505
Score = 87.4 bits (215), Expect = 4e-17
Identities = 72/296 (24%), Positives = 134/296 (45%), Gaps = 36/296 (12%)
Query: 300 PVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDST 359
P + RE LE++ + + S+ ++D +++ + G + +R W+ L GY P +
Sbjct: 176 PPMTVREKTRLEKFRQLLSSQNT--DLDELRKCSWPG-VPREVRPITWRLLSGYLP--AN 230
Query: 360 KEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQ 419
E R ++K +EYF Q+ E+ +++ YR I D+ RT+ + Q
Sbjct: 231 TERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDT----YRQ-IHIDIPRTNPLIPLF--Q 283
Query: 420 DNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYV---------MEN---------- 460
+ IL + + GYVQG++DL++P V +EN
Sbjct: 284 QPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDM 343
Query: 461 ----EVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYL 516
E D+FWC + +D + N+ G++ ++ L L+ +D ++ + YL
Sbjct: 344 LRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYL 403
Query: 517 YFCFRWLLIRFKREFSFLDILRLWEVMWTELP-CTNFHLLLCCAILESEKQQIMEK 571
F FRW+ RE +RLW+ +E ++FHL +C A L +++I+++
Sbjct: 404 QFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDE 459
>gi|22507409 TBC1 domain family, member 22A [Homo sapiens]
Length = 517
Score = 87.4 bits (215), Expect = 4e-17
Identities = 77/296 (26%), Positives = 125/296 (42%), Gaps = 40/296 (13%)
Query: 337 GLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRL- 395
G+ +R WK L GY P + + T +KQK EYF I + RN +
Sbjct: 222 GIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQK--EYFAF------IEHYYDSRNDEVH 273
Query: 396 RDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLL 455
+D I D+ R + + + IL + + GYVQG++DL++P
Sbjct: 274 QDTYRQIHIDIPRMSPEALILQPKVTE---IFERILFIWAIRHPASGYVQGINDLVTPFF 330
Query: 456 YVM------------------------ENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLI 491
V E D +WC + +D + N+ G++ ++
Sbjct: 331 VVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVK 390
Query: 492 QLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELP-CT 550
L L+ +D +L+ + YL F FRW+ RE +RLW+ +E +
Sbjct: 391 MLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFS 450
Query: 551 NFHLLLCCAILESEKQQIMEKHYGFNEILKHINEL-SMKIDVEDI-LCKAEAISLQ 604
+FHL +C A L +++I+E+ F E+L + L + D EDI L AEA L+
Sbjct: 451 HFHLYVCAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDISLLLAEAYRLK 505
>gi|190014603 TBC1 domain family, member 13 [Homo sapiens]
Length = 400
Score = 80.9 bits (198), Expect = 4e-15
Identities = 51/186 (27%), Positives = 94/186 (50%), Gaps = 17/186 (9%)
Query: 430 ILMTYCMYDFDLGYVQGMSDLLSPLLYVMEN----------EVDAFWCFASYMDQMHQNF 479
IL Y + + YVQGM++++ PL Y E D F+CF + M ++ NF
Sbjct: 214 ILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLMAEIRDNF 273
Query: 480 ----EEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLD 535
++ G+ ++ ++ + L+ D L+ Q+ +F FRWL + +EF D
Sbjct: 274 IKSLDDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLSQEFLLPD 333
Query: 536 ILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDIL 595
++R+W+ ++ + +F LL+CCA+L ++Q++E + N L ++ DV IL
Sbjct: 334 VIRIWDSLFADDNRFDFLLLVCCAMLMLIREQLLEGDFTVNMRLLQDYPIT---DVCQIL 390
Query: 596 CKAEAI 601
KA+ +
Sbjct: 391 QKAKEL 396
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 67.0 bits (162), Expect = 5e-11
Identities = 59/248 (23%), Positives = 108/248 (43%), Gaps = 30/248 (12%)
Query: 302 VQRREPVSLE---EWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDS 358
V+R++ + +E +W K + + N + + I++G + LR + W LL
Sbjct: 63 VERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKG-IPLQLRGEVWALLL------- 114
Query: 359 TKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEG 418
E +++++ D Y ++K + + S + + I+ DVNRT R + +
Sbjct: 115 ---EIPKMKEETRDLYSKLKHRARGCSPDIRQ-----------IDLDVNRTFRDHIMFRD 160
Query: 419 QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWC----FASYMDQ 474
+ L +L Y +Y+ ++GY QGMS + + LL M NE DAFW F+
Sbjct: 161 RYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYM-NEEDAFWALVKLFSGPKHA 219
Query: 475 MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFL 534
MH F + + +L S +L+SQ+ ++ +W F F
Sbjct: 220 MHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFT 279
Query: 535 DILRLWEV 542
LR+W++
Sbjct: 280 LNLRIWDI 287
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 67.0 bits (162), Expect = 5e-11
Identities = 59/248 (23%), Positives = 108/248 (43%), Gaps = 30/248 (12%)
Query: 302 VQRREPVSLE---EWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDS 358
V+R++ + +E +W K + + N + + I++G + LR + W LL
Sbjct: 80 VERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKG-IPLQLRGEVWALLL------- 131
Query: 359 TKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEG 418
E +++++ D Y ++K + + S + + I+ DVNRT R + +
Sbjct: 132 ---EIPKMKEETRDLYSKLKHRARGCSPDIRQ-----------IDLDVNRTFRDHIMFRD 177
Query: 419 QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWC----FASYMDQ 474
+ L +L Y +Y+ ++GY QGMS + + LL M NE DAFW F+
Sbjct: 178 RYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYM-NEEDAFWALVKLFSGPKHA 236
Query: 475 MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFL 534
MH F + + +L S +L+SQ+ ++ +W F F
Sbjct: 237 MHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFT 296
Query: 535 DILRLWEV 542
LR+W++
Sbjct: 297 LNLRIWDI 304
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 67.0 bits (162), Expect = 5e-11
Identities = 63/262 (24%), Positives = 117/262 (44%), Gaps = 24/262 (9%)
Query: 313 WTKNIDSEGRI---LNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQ 369
W K + + GR +++ M + +G H R + WKFL E+ L+ Q
Sbjct: 774 WEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHH-RGEIWKFLA----------EQFHLKHQ 822
Query: 370 KTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHD 429
F K Q K + ++ + + + LI D+ RT T+ ++ Q G + L++
Sbjct: 823 -----FPSKQQPKDVPYKELLKQLTSQQHAILI--DLGRTFPTHPYFSAQLGAGQLSLYN 875
Query: 430 ILMTYCMYDFDLGYVQGMSDLLS-PLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKT 488
IL Y + D ++GY QG+S + LL++ E E F + + + + M ++
Sbjct: 876 ILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQI 935
Query: 489 QLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELP 548
Q+ QLS LL ++LE + G + W L F +F + R++++++ L
Sbjct: 936 QMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIF--LQ 993
Query: 549 CTNFHLLLCCAILESEKQQIME 570
T + ++L S K I++
Sbjct: 994 GTEVIFKVALSLLGSHKPLILQ 1015
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 64.7 bits (156), Expect = 3e-10
Identities = 76/346 (21%), Positives = 136/346 (39%), Gaps = 56/346 (16%)
Query: 258 STHQRPPSEM-ADFLSDAIPGLKINQQEEP----------------GFEVITRIDLGERP 300
S Q P E+ A L DA L++ QE+P GF + D E+
Sbjct: 555 SEDQGPTREVIAQLLEDA---LQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEEKL 611
Query: 301 VVQRREP-------VSLEEWTKNIDSEGRILNVDNMKQM-------IFRGGLSHALRKQA 346
V + R +E + + E + N + M + R G+ H R +
Sbjct: 612 VAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLIRAGIPHEHRSKV 671
Query: 347 WKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDV 406
WK+ + + T+ K T+ L K++ EK+N + IE D+
Sbjct: 672 WKWCV---------DRHTRKFKDNTEPGHFQTLLQKAL----EKQNPASKQ----IELDL 714
Query: 407 NRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFW 466
RT NK Y + G+ L ++L+ + + D+GY QG++ L++ L +E E DAFW
Sbjct: 715 LRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQE-DAFW 773
Query: 467 CFASYMD--QMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLL 524
C + ++ + + + G + L+ + E Y F W L
Sbjct: 774 CLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFL 833
Query: 525 IRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIME 570
+ F + ++W+ E P F L A+ + ++++I++
Sbjct: 834 VVFVDSVVSDILFKIWDSFLYEGPKVIFRFAL--ALFKYKEEEILK 877
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 64.7 bits (156), Expect = 3e-10
Identities = 76/346 (21%), Positives = 136/346 (39%), Gaps = 56/346 (16%)
Query: 258 STHQRPPSEM-ADFLSDAIPGLKINQQEEP----------------GFEVITRIDLGERP 300
S Q P E+ A L DA L++ QE+P GF + D E+
Sbjct: 555 SEDQGPTREVIAQLLEDA---LQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEEKL 611
Query: 301 VVQRREP-------VSLEEWTKNIDSEGRILNVDNMKQM-------IFRGGLSHALRKQA 346
V + R +E + + E + N + M + R G+ H R +
Sbjct: 612 VAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLIRAGIPHEHRSKV 671
Query: 347 WKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDV 406
WK+ + + T+ K T+ L K++ EK+N + IE D+
Sbjct: 672 WKWCV---------DRHTRKFKDNTEPGHFQTLLQKAL----EKQNPASKQ----IELDL 714
Query: 407 NRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFW 466
RT NK Y + G+ L ++L+ + + D+GY QG++ L++ L +E E DAFW
Sbjct: 715 LRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQE-DAFW 773
Query: 467 CFASYMD--QMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLL 524
C + ++ + + + G + L+ + E Y F W L
Sbjct: 774 CLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFL 833
Query: 525 IRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIME 570
+ F + ++W+ E P F L A+ + ++++I++
Sbjct: 834 VVFVDSVVSDILFKIWDSFLYEGPKVIFRFAL--ALFKYKEEEILK 877
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 63.9 bits (154), Expect = 5e-10
Identities = 43/167 (25%), Positives = 80/167 (47%), Gaps = 3/167 (1%)
Query: 405 DVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP-LLYVMENEVD 463
D+ RT T+ ++ Q PG + L ++L Y + D ++GY QG+S + LL++ E +
Sbjct: 969 DLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAF 1028
Query: 464 AFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWL 523
F Y + + M ++ Q+ QLS LL ++LE + + W
Sbjct: 1029 EMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWF 1088
Query: 524 LIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIME 570
L F +FS + R++++++ L T + ++L S++ IME
Sbjct: 1089 LTLFASQFSLGFVARVFDIIF--LQGTEVIFKVALSLLSSQETLIME 1133
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 60.1 bits (144), Expect = 7e-09
Identities = 56/238 (23%), Positives = 100/238 (42%), Gaps = 26/238 (10%)
Query: 335 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR 394
R G+ R + W L G Q Q + Y+ LQ + RN R
Sbjct: 66 RKGVPLEHRARVWMVLSG-----------AQAQMDQNPGYYHQLLQGE--------RNPR 106
Query: 395 LRDYRSLIEKDVNRTDRTNKFYEGQDNPGLI-LLHDILMTYCMYDFDLGYVQGMSDLLSP 453
L D I D+NRT N + +P L L+++L+ Y ++ +GY QGM+ +
Sbjct: 107 LED---AIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGY 163
Query: 454 LLYVMENEVDAFWCFASYMDQ-MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQD 512
L+ + NE ++FW + + + + + M G+KT L L+R + +E
Sbjct: 164 LILITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLG 223
Query: 513 SGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIME 570
+ RW + F +LR+W+ ++ E F + L +++ ++ I+E
Sbjct: 224 VLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVAL--TLIKQHQELILE 279
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 58.5 bits (140), Expect = 2e-08
Identities = 82/370 (22%), Positives = 154/370 (41%), Gaps = 40/370 (10%)
Query: 250 DSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVS 309
+SL G+ S Q P + D LS + N E + I +G + E V
Sbjct: 17 ESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFI-VGSQGAEGALEEVP 75
Query: 310 LE-------EWTKNIDSEGRILNVDNMK-QMIFRGGLSHALRKQAWKFLLGYFPWDSTKE 361
LE +W +++ + + + K ++ + G+ +LR +AW++L G +
Sbjct: 76 LEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSG-------GK 128
Query: 362 ERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDN 421
+ Q K DE +S K + +IE+D++R ++ + +
Sbjct: 129 VKLQQNPGKFDEL--------DMSPGDPK-------WLDVIERDLHRQFPFHEMFVSRGG 173
Query: 422 PGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQ-MHQNFE 480
G L +L Y +Y + GY Q + + + LL M E AFWC ++ + +
Sbjct: 174 HGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAE-QAFWCLVQICEKYLPGYYS 232
Query: 481 EQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLW 540
E+++ ++ L +LL+ + +L Q L + W + F R + +LR+W
Sbjct: 233 EKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVW 292
Query: 541 EVMWTELPCTNFH---LLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCK 597
++ + E F +LL A+ EK + + Y E ++ + LS KI E L +
Sbjct: 293 DMFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQY---ETIERLRSLSPKIMQEAFLVQ 349
Query: 598 AEAISLQMVK 607
E + L + +
Sbjct: 350 -EVVELPVTE 358
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 58.2 bits (139), Expect = 3e-08
Identities = 60/270 (22%), Positives = 111/270 (41%), Gaps = 44/270 (16%)
Query: 310 LEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQ 369
L +W N+ + + L+ + + G+ ALR + W+ L G + + L +
Sbjct: 517 LGKWHSNLGARPKGLST------LVKSGVPEALRAEVWQLLAG------CHDNQAMLDRY 564
Query: 370 KTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHD 429
+ L K +QE S+I +D++RT + +++ G L+
Sbjct: 565 RI-------LITKDSAQE------------SVITRDIHRTFPAHDYFKDTGGDGQESLYK 605
Query: 430 ILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYM------DQMHQNFEEQM 483
I Y +YD D+GY QG S L + LL M E AF M D NFE+
Sbjct: 606 ICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEE-QAFCVLVKIMYDYGLRDLYRNNFED-- 662
Query: 484 QGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVM 543
+ + QL L++ S+ + + +W L F +F + + +++
Sbjct: 663 --LHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLL 720
Query: 544 WTELPCTNFHLLLCCAILESEKQQIMEKHY 573
E FH+ L A+L++ K+ +++ +
Sbjct: 721 LCEGLNIIFHVAL--ALLKTSKEDLLQADF 748
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 57.0 bits (136), Expect = 6e-08
Identities = 68/304 (22%), Positives = 123/304 (40%), Gaps = 40/304 (13%)
Query: 272 SDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQ 331
S IP + +EE E + G V + LE W + + LNV KQ
Sbjct: 503 SSVIPSPPEDDEEEDNDEPLLS---GSGDVSKECAEKILETWGELLSKWHLNLNV-RPKQ 558
Query: 332 M--IFRGGLSHALRKQAWKFLLGYFPWDSTKEE-RTQLQKQKTDEYFRMKLQWKSISQEQ 388
+ + R G+ ALR + W+ L G D E+ R + K+ +
Sbjct: 559 LSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQD--------------- 603
Query: 389 EKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMS 448
S I +D+NRT + +++ G L+ I Y +YD ++GY QG S
Sbjct: 604 -----------SAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQS 652
Query: 449 DLLSPLLYVMENEVDAFWCFASYMDQ--MHQNFEEQMQGMKTQLIQLSTLLR-LLDSGFC 505
L + LL M E AF M + + F++ + + + QL L++ + +
Sbjct: 653 FLAAVLLLHMPEE-QAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYN 711
Query: 506 SYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEK 565
+L+ ++Y +W L F +F + + +++ E F++ L +L++ K
Sbjct: 712 HFLDISLEAHMY-ASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVAL--GLLKTSK 768
Query: 566 QQIM 569
++
Sbjct: 769 DDLL 772
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 56.6 bits (135), Expect = 7e-08
Identities = 71/319 (22%), Positives = 123/319 (38%), Gaps = 36/319 (11%)
Query: 259 THQRPPSEMADFLSDAIPGLKINQQE--EPGFEVITRIDLGERPVVQRREPVSLEEWTKN 316
T + +E +F D G ++ ++E EPG ++ L E + R LE +T N
Sbjct: 29 TQKEESAEQPEFYYDEF-GFRVYKEEGDEPGSSLLANSPLMEDAPQRLRWQAHLE-FTHN 86
Query: 317 IDSEG--------RILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQK 368
D + + ++ ++ G+ H +R Q W L G LQK
Sbjct: 87 HDVGDLTWDKIAVSLPRSEKLRSLVL-AGIPHGMRPQLWMRLSG------------ALQK 133
Query: 369 QKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLH 428
++ E ++ S + E IEKD+ RT +N + + G+ L
Sbjct: 134 KRNSELSYREIVKNSSNDETIAAKQ--------IEKDLLRTMPSNACFASMGSIGVPRLR 185
Query: 429 DILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQM--HQNFEEQMQGM 486
+L ++GY QG + + LL +E E DAFW ++ ++ + F + G+
Sbjct: 186 RVLRALAWLYPEIGYCQGTGMVAACLLLFLEEE-DAFWMMSAIIEDLLPASYFSTTLLGV 244
Query: 487 KTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTE 546
+T L L+ L+ D W L F +LR+W++ + E
Sbjct: 245 QTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYE 304
Query: 547 LPCTNFHLLLCCAILESEK 565
F L L L+ E+
Sbjct: 305 GSRVLFQLTLGMLHLKEEE 323
>gi|229577000 ecotropic viral integration site 5-like isoform 1
[Homo sapiens]
Length = 805
Score = 55.1 bits (131), Expect = 2e-07
Identities = 48/214 (22%), Positives = 96/214 (44%), Gaps = 6/214 (2%)
Query: 401 LIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMEN 460
LI +D+ RT ++F++GQD+ G +L +++ Y + D ++GY QG + ++ LL M
Sbjct: 153 LIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPE 212
Query: 461 EVDAFWCFASYMDQ--MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYF 518
E +AF F M + + + F+ M + + Q +L+ ++ SQ +
Sbjct: 213 E-EAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMY 271
Query: 519 CFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY-GFNE 577
W L F F R++++ E F + L A+L+ + ++M+ G ++
Sbjct: 272 ASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGL--ALLQVNQAELMQLDMEGMSQ 329
Query: 578 ILKHINELSMKIDVEDILCKAEAISLQMVKCKEL 611
+ + + ++ KA + K K L
Sbjct: 330 YFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRL 363
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 55.1 bits (131), Expect = 2e-07
Identities = 48/214 (22%), Positives = 96/214 (44%), Gaps = 6/214 (2%)
Query: 401 LIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMEN 460
LI +D+ RT ++F++GQD+ G +L +++ Y + D ++GY QG + ++ LL M
Sbjct: 153 LIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPE 212
Query: 461 EVDAFWCFASYMDQ--MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYF 518
E +AF F M + + + F+ M + + Q +L+ ++ SQ +
Sbjct: 213 E-EAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMY 271
Query: 519 CFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY-GFNE 577
W L F F R++++ E F + L A+L+ + ++M+ G ++
Sbjct: 272 ASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGL--ALLQVNQAELMQLDMEGMSQ 329
Query: 578 ILKHINELSMKIDVEDILCKAEAISLQMVKCKEL 611
+ + + ++ KA + K K L
Sbjct: 330 YFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRL 363
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 54.7 bits (130), Expect = 3e-07
Identities = 57/262 (21%), Positives = 102/262 (38%), Gaps = 24/262 (9%)
Query: 335 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR 394
R G+ +LR +AW++L S +E + K +E R K
Sbjct: 358 RKGIPSSLRAKAWQYL-------SNSKELLEQNPGKFEELERAPGDPK------------ 398
Query: 395 LRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPL 454
+ +IEKD++R ++ + + G L+ IL Y +Y D GY Q + + + L
Sbjct: 399 ---WLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVL 455
Query: 455 LYVMENEVDAFWCFASYMDQ-MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS 513
L M E AFWC D+ + + ++ ++ LLR +L Q
Sbjct: 456 LMHMPAE-QAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRI 514
Query: 514 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY 573
+ + W + F R + +LR+W++ + E F + L + +
Sbjct: 515 DPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQ 574
Query: 574 GFNEILKHINELSMKIDVEDIL 595
G E ++ + L + ED L
Sbjct: 575 GMYETMEQLRNLPQQCMQEDFL 596
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,810,276
Number of Sequences: 37866
Number of extensions: 1237003
Number of successful extensions: 3806
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 3673
Number of HSP's gapped (non-prelim): 112
length of query: 682
length of database: 18,247,518
effective HSP length: 109
effective length of query: 573
effective length of database: 14,120,124
effective search space: 8090831052
effective search space used: 8090831052
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.