Search of human proteins with 226342865

Search of human proteins with 226342865

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo
sapiens]
         (713 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]  1453   0.0  
gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]  1405   0.0  
gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]  1344   0.0  
gi|13375952 TBC1 domain family, member 17 [Homo sapiens]              586   e-167
gi|33563376 TBC1 domain family, member 16 [Homo sapiens]              202   7e-52
gi|54607014 TBC1 domain family, member 25 [Homo sapiens]              179   6e-45
gi|23503283 TBC1 domain family, member 21 [Homo sapiens]              136   6e-32
gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sa...   129   1e-29
gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sa...   129   1e-29
gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa...   125   1e-28
gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa...   125   1e-28
gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap...   125   1e-28
gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap...   125   1e-28
gi|40068063 TBC1 domain family, member 22B [Homo sapiens]              87   4e-17
gi|22507409 TBC1 domain family, member 22A [Homo sapiens]              87   4e-17
gi|190014603 TBC1 domain family, member 13 [Homo sapiens]              81   4e-15
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]               67   6e-11
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]             67   6e-11
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member...    67   6e-11
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]    65   3e-10
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]    65   3e-10
gi|114688046 TBC1 domain family, member 4 [Homo sapiens]               64   5e-10
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]     60   7e-09
gi|13994322 TBC1 domain family, member 10A [Homo sapiens]              59   2e-08
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo...    58   3e-08
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]            57   6e-08
gi|29648315 small G protein signaling modulator 3 [Homo sapiens]       57   8e-08
gi|229577000 ecotropic viral integration site 5-like isoform 1 [...    55   2e-07
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H...    55   2e-07
gi|167614488 TBC1 domain family, member 10B [Homo sapiens]             55   3e-07

>gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]
          Length = 713

 Score = 1453 bits (3762), Expect = 0.0
 Identities = 713/713 (100%), Positives = 713/713 (100%)

Query: 1   MLLYVRETREVLLRHYQARAGNMAAAGVVSGKIIYEQEGVYIHSSCGKTNDQDGLISGIL 60
           MLLYVRETREVLLRHYQARAGNMAAAGVVSGKIIYEQEGVYIHSSCGKTNDQDGLISGIL
Sbjct: 1   MLLYVRETREVLLRHYQARAGNMAAAGVVSGKIIYEQEGVYIHSSCGKTNDQDGLISGIL 60

Query: 61  RVLEKDAEVIVDWRPLDDALDSSSILYARKDSSSVVEWTQAPKERGHRGSEHLNSYEAEW 120
           RVLEKDAEVIVDWRPLDDALDSSSILYARKDSSSVVEWTQAPKERGHRGSEHLNSYEAEW
Sbjct: 61  RVLEKDAEVIVDWRPLDDALDSSSILYARKDSSSVVEWTQAPKERGHRGSEHLNSYEAEW 120

Query: 121 DMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLFSLTDLKSIKQNKEGMGWSYLVFCLKDDV 180
           DMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLFSLTDLKSIKQNKEGMGWSYLVFCLKDDV
Sbjct: 121 DMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLFSLTDLKSIKQNKEGMGWSYLVFCLKDDV 180

Query: 181 VLPALHFHQGDSKLLIESLEKYVVLCESPQDKRTLLVNCQNKSLSQSFENLLDEPAYGLI 240
           VLPALHFHQGDSKLLIESLEKYVVLCESPQDKRTLLVNCQNKSLSQSFENLLDEPAYGLI
Sbjct: 181 VLPALHFHQGDSKLLIESLEKYVVLCESPQDKRTLLVNCQNKSLSQSFENLLDEPAYGLI 240

Query: 241 QAGLLDRRKLLWAIHHWKKIKKDPYTATMIGFSKVTNYIFDSLRGSDPSTHQRPPSEMAD 300
           QAGLLDRRKLLWAIHHWKKIKKDPYTATMIGFSKVTNYIFDSLRGSDPSTHQRPPSEMAD
Sbjct: 241 QAGLLDRRKLLWAIHHWKKIKKDPYTATMIGFSKVTNYIFDSLRGSDPSTHQRPPSEMAD 300

Query: 301 FLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNM 360
           FLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNM
Sbjct: 301 FLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNM 360

Query: 361 KQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQE 420
           KQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQE
Sbjct: 361 KQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQE 420

Query: 421 KRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSD 480
           KRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSD
Sbjct: 421 KRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSD 480

Query: 481 LLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLE 540
           LLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLE
Sbjct: 481 LLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLE 540

Query: 541 SQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIM 600
           SQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIM
Sbjct: 541 SQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIM 600

Query: 601 EKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTP 660
           EKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTP
Sbjct: 601 EKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTP 660

Query: 661 DSDVGEDENVVMTPCPTSAFQSNALPTLSASGARNDSPTQIPVSSDVCRLTPA 713
           DSDVGEDENVVMTPCPTSAFQSNALPTLSASGARNDSPTQIPVSSDVCRLTPA
Sbjct: 661 DSDVGEDENVVMTPCPTSAFQSNALPTLSASGARNDSPTQIPVSSDVCRLTPA 713


>gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]
          Length = 696

 Score = 1405 bits (3636), Expect = 0.0
 Identities = 696/713 (97%), Positives = 696/713 (97%), Gaps = 17/713 (2%)

Query: 1   MLLYVRETREVLLRHYQARAGNMAAAGVVSGKIIYEQEGVYIHSSCGKTNDQDGLISGIL 60
           MLLYVRETREVLLRHYQARAGNMAAAGVVSGKIIYEQEGVYIHSSCGKTNDQDGLISGIL
Sbjct: 1   MLLYVRETREVLLRHYQARAGNMAAAGVVSGKIIYEQEGVYIHSSCGKTNDQDGLISGIL 60

Query: 61  RVLEKDAEVIVDWRPLDDALDSSSILYARKDSSSVVEWTQAPKERGHRGSEHLNSYEAEW 120
           RVLEKDAEVIVDWRPLDDALDSSSILYARKDSSSVVEWTQAPKERGHRGSEHLNSYEAEW
Sbjct: 61  RVLEKDAEVIVDWRPLDDALDSSSILYARKDSSSVVEWTQAPKERGHRGSEHLNSYEAEW 120

Query: 121 DMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLFSLTDLKSIKQNKEGMGWSYLVFCLKDDV 180
           DMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLFSLTDLKSIKQNKEGMGWSYLVFCLKDDV
Sbjct: 121 DMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLFSLTDLKSIKQNKEGMGWSYLVFCLKDDV 180

Query: 181 VLPALHFHQGDSKLLIESLEKYVVLCESPQDKRTLLVNCQNKSLSQSFENLLDEPAYGLI 240
           VLPALHFHQGDSKLLIESLEKYVVLCESPQDKRTLLVNCQNKSLSQSFENLLDEPAYGLI
Sbjct: 181 VLPALHFHQGDSKLLIESLEKYVVLCESPQDKRTLLVNCQNKSLSQSFENLLDEPAYGLI 240

Query: 241 QAGLLDRRKLLWAIHHWKKIKKDPYTATMIGFSKVTNYIFDSLRGSDPSTHQRPPSEMAD 300
           Q                 KIKKDPYTATMIGFSKVTNYIFDSLRGSDPSTHQRPPSEMAD
Sbjct: 241 Q-----------------KIKKDPYTATMIGFSKVTNYIFDSLRGSDPSTHQRPPSEMAD 283

Query: 301 FLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNM 360
           FLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNM
Sbjct: 284 FLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNM 343

Query: 361 KQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQE 420
           KQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQE
Sbjct: 344 KQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQE 403

Query: 421 KRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSD 480
           KRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSD
Sbjct: 404 KRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSD 463

Query: 481 LLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLE 540
           LLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLE
Sbjct: 464 LLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLE 523

Query: 541 SQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIM 600
           SQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIM
Sbjct: 524 SQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIM 583

Query: 601 EKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTP 660
           EKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTP
Sbjct: 584 EKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTP 643

Query: 661 DSDVGEDENVVMTPCPTSAFQSNALPTLSASGARNDSPTQIPVSSDVCRLTPA 713
           DSDVGEDENVVMTPCPTSAFQSNALPTLSASGARNDSPTQIPVSSDVCRLTPA
Sbjct: 644 DSDVGEDENVVMTPCPTSAFQSNALPTLSASGARNDSPTQIPVSSDVCRLTPA 696


>gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]
          Length = 682

 Score = 1344 bits (3479), Expect = 0.0
 Identities = 664/681 (97%), Positives = 664/681 (97%), Gaps = 17/681 (2%)

Query: 33  IIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKDS 92
           IIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKDS
Sbjct: 19  IIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKDS 78

Query: 93  SSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLF 152
           SSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLF
Sbjct: 79  SSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFKRKPHTNGDAPSHRNGKSKWSFLF 138

Query: 153 SLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESPQDK 212
           SLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESPQDK
Sbjct: 139 SLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESPQDK 198

Query: 213 RTLLVNCQNKSLSQSFENLLDEPAYGLIQAGLLDRRKLLWAIHHWKKIKKDPYTATMIGF 272
           RTLLVNCQNKSLSQSFENLLDEPAYGLIQ                 KIKKDPYTATMIGF
Sbjct: 199 RTLLVNCQNKSLSQSFENLLDEPAYGLIQ-----------------KIKKDPYTATMIGF 241

Query: 273 SKVTNYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPV 332
           SKVTNYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPV
Sbjct: 242 SKVTNYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPV 301

Query: 333 VQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKE 392
           VQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKE
Sbjct: 302 VQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKE 361

Query: 393 ERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDN 452
           ERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDN
Sbjct: 362 ERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDN 421

Query: 453 PGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEE 512
           PGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEE
Sbjct: 422 PGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEE 481

Query: 513 QMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWE 572
           QMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWE
Sbjct: 482 QMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWE 541

Query: 573 VMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAI 632
           VMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAI
Sbjct: 542 VMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAI 601

Query: 633 SLQMVKCKELPQAVCEILGLQGSEVTTPDSDVGEDENVVMTPCPTSAFQSNALPTLSASG 692
           SLQMVKCKELPQAVCEILGLQGSEVTTPDSDVGEDENVVMTPCPTSAFQSNALPTLSASG
Sbjct: 602 SLQMVKCKELPQAVCEILGLQGSEVTTPDSDVGEDENVVMTPCPTSAFQSNALPTLSASG 661

Query: 693 ARNDSPTQIPVSSDVCRLTPA 713
           ARNDSPTQIPVSSDVCRLTPA
Sbjct: 662 ARNDSPTQIPVSSDVCRLTPA 682


>gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
          Length = 648

 Score =  586 bits (1511), Expect = e-167
 Identities = 311/626 (49%), Positives = 415/626 (66%), Gaps = 43/626 (6%)

Query: 32  KIIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKD 91
           ++++E+ GVY+H+S  K  D+D LI+G++RV+EKD +V++ W P+++A DS+ IL+++KD
Sbjct: 7   RVVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQILFSKKD 66

Query: 92  SSSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFK--RKPHTNGDAPSHRNGKSKWS 149
           SS         +     G      YE +W +++TV  +      T G  PS   G   W+
Sbjct: 67  SSGGDSCASEEEPTFDPG------YEPDWAVISTVRPQPCHSEPTRGAEPSCPQGS--WA 118

Query: 150 FLFSLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESP 209
           F  SL +LKSI+++K G+ W+YLV   +    LPALHFH+G ++ L+  L +Y++L  SP
Sbjct: 119 FSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSP 178

Query: 210 QDKRTLLVNCQNKS-LSQSFENL--LDEPAYGLIQAGLLDRRKLLWAIHHWKKIKKDPYT 266
           QD R  LV   + S LS SF +L   D+ +  ++   L                 +DPY+
Sbjct: 179 QDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFL-----------------QDPYS 221

Query: 267 ATMIGFSKVTNYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRID 326
            T   FS+VTN+   +L+         P  E A   SD  P    + + EPGFEVI+ ++
Sbjct: 222 TTFSSFSRVTNFFRGALQ---------PQPEGA--ASDLPP--PPDDEPEPGFEVISCVE 268

Query: 327 LGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFP 386
           LG RP V+R  PV+ EEW +++  EGR+  V  +K  IF GGLS +LR++AWKFLLGY  
Sbjct: 269 LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328

Query: 387 WDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKF 446
           W+ T EE     ++KTDEYFRMKLQWKS+S EQE+RNS L  YRSLIE+DV+RTDRTNKF
Sbjct: 329 WEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKF 388

Query: 447 YEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQM 506
           YEG +NPGL LL+DIL+TYCMY FDLGYVQGMSDLLSP+LYV++NEVDAFWCF  +M+ +
Sbjct: 389 YEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELV 448

Query: 507 HQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLD 566
             NFEE  + MK QL +L  LLR+LD   C +L+SQDSG L FCFRWLLI FKREF F D
Sbjct: 449 QGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPD 508

Query: 567 ILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDIL 626
           +LRLWEV+WT LP  N HLL+ CAIL+ E+  +M   +G NEILKHINEL+MK+ VED+L
Sbjct: 509 VLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVL 568

Query: 627 CKAEAISLQMVKCKELPQAVCEILGL 652
            +AEA+  Q+  C ELP  V EILGL
Sbjct: 569 TRAEALHRQLTACPELPHNVQEILGL 594


>gi|33563376 TBC1 domain family, member 16 [Homo sapiens]
          Length = 767

 Score =  202 bits (515), Expect = 7e-52
 Identities = 109/319 (34%), Positives = 178/319 (55%), Gaps = 4/319 (1%)

Query: 339 VSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQ 398
           + +  W  +++  G++     +++ IF GG+  ++R + W FLL Y+  +ST EER  L+
Sbjct: 396 LGVSAWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALR 455

Query: 399 KQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILL 458
            QK  EY   ++Q K +S   E+  +  R+ +  ++KDV RTDR N+F+ G+DNP +  +
Sbjct: 456 LQKRKEY--SEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESM 513

Query: 459 HDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMK 518
             IL+ Y +Y+  +GY QGMSDL++P+L  + +E D FWCF   M         + + M+
Sbjct: 514 RRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDME 573

Query: 519 TQLIQLSTLLRLLDSGFCSYLES--QDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWT 576
            QL+ L  LLRL    F  +L S  +D   + FC RWLL+ FKREF   + LR+WE  W 
Sbjct: 574 KQLLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWA 633

Query: 577 ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQM 636
                 FHL +C AI+      ++E+    +++L H   L+M ++ E +L KA ++  Q 
Sbjct: 634 HYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQF 693

Query: 637 VKCKELPQAVCEILGLQGS 655
                +P ++ ++  L GS
Sbjct: 694 RLLPRIPCSLHDLCKLCGS 712


>gi|54607014 TBC1 domain family, member 25 [Homo sapiens]
          Length = 688

 Score =  179 bits (455), Expect = 6e-45
 Identities = 95/245 (38%), Positives = 141/245 (57%), Gaps = 6/245 (2%)

Query: 336 REPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERT 395
           + P+S  E+   ++ EG++   + ++  I+ GG+  +LRK  W++LL  +P   T  ER 
Sbjct: 196 KPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERM 255

Query: 396 QLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEG-QDNPG 454
              K+K+ EY ++K +W   +  ++     L   RS + KDV RTDR + +Y G +D P 
Sbjct: 256 DYMKRKSREYEQLKSEWAQRANPED-----LEFIRSTVLKDVLRTDRAHPYYAGPEDGPH 310

Query: 455 LILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQM 514
           L  LHD+L TY +    + Y QGMSDL SP+L VM++E  AF CF   M ++  NF    
Sbjct: 311 LRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG 370

Query: 515 QGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVM 574
           + M T+   L  LLR  D  F  YL+   +  L+FC+RWLL+  KREF+F D LR+ EV 
Sbjct: 371 RAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVT 430

Query: 575 WTELP 579
           W+ LP
Sbjct: 431 WSSLP 435



 Score = 33.1 bits (74), Expect = 0.92
 Identities = 17/50 (34%), Positives = 25/50 (50%)

Query: 583 FHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAI 632
           F L LC AIL   +  IM     +NE+  H + L  K  +  +L +A A+
Sbjct: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666


>gi|23503283 TBC1 domain family, member 21 [Homo sapiens]
          Length = 336

 Score =  136 bits (343), Expect = 6e-32
 Identities = 87/322 (27%), Positives = 164/322 (50%), Gaps = 17/322 (5%)

Query: 332 VVQRREPVSLEEWTKNIDSEGRILNV-DNMKQMIFRGGLSHALRKQAWKFLLGYFPWDST 390
           +V+R+ P+   EW    D  G +    D +   I   GL   +R +AWKFL GYF W S+
Sbjct: 20  LVKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHPFVRTEAWKFLTGYFSWQSS 79

Query: 391 KEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQ 450
           ++ER  +   +   Y  +   ++ I    E  +    + R+ I +D+       K Y+ +
Sbjct: 80  QDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRNNIARDIQ------KIYD-K 132

Query: 451 DNPGLIL-----LHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQ 505
           D  G +L     L  IL+   + +    Y QG  +++     ++E++ + FW F  ++ +
Sbjct: 133 DPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQK 192

Query: 506 MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREF-SF 564
              +    + G+   L  LSTL+  LD  F  +L+ + +G +   F W    F+R F SF
Sbjct: 193 TEHSCVINI-GVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSF 251

Query: 565 LDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVED 624
            D+ RLWEV+ T  PC NF +L+  ++L+  ++Q++++  G ++IL   N L + +D ++
Sbjct: 252 DDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLACNNL-IDLDADE 310

Query: 625 ILCKAEAISLQMVKCKELPQAV 646
           ++  A  +  ++++ K++PQ +
Sbjct: 311 LISAACVVYAELIQ-KDVPQTL 331


>gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo
           sapiens]
          Length = 1006

 Score =  129 bits (323), Expect = 1e-29
 Identities = 69/197 (35%), Positives = 113/197 (57%), Gaps = 7/197 (3%)

Query: 433 IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 492
           I+KDV R DR   ++     P L  L D++ +Y     D+GYVQGM DLL+PLL  ++N+
Sbjct: 797 IDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDND 853

Query: 493 VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 551
             A+ CF+  M +M QNF      M T    + +L+++LDS     + ++ D  + YFC+
Sbjct: 854 QLAYSCFSHLMKRMSQNFPNG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 912

Query: 552 RWLLIRFKREFSFLDILRLWEVMWT--ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEI 609
           RW L+ FKRE  + D+  +WEV+W    +   +F L +  A++E+ ++ I + +  F +I
Sbjct: 913 RWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDI 972

Query: 610 LKHINELSMKIDVEDIL 626
           +K  NE +   D ++IL
Sbjct: 973 IKFFNERAEHHDAQEIL 989



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 1/71 (1%)

Query: 344 WTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTD 403
           W+K    +     ++ ++Q ++ GG+ H +RK  W FLLG++ +  +K+E  Q+      
Sbjct: 543 WSKYQKDKKNYKELELLRQ-VYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAA 601

Query: 404 EYFRMKLQWKS 414
            Y ++  +WK+
Sbjct: 602 RYQQVLAEWKA 612


>gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 1051

 Score =  129 bits (323), Expect = 1e-29
 Identities = 69/197 (35%), Positives = 113/197 (57%), Gaps = 7/197 (3%)

Query: 433  IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 492
            I+KDV R DR   ++     P L  L D++ +Y     D+GYVQGM DLL+PLL  ++N+
Sbjct: 842  IDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDND 898

Query: 493  VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 551
              A+ CF+  M +M QNF      M T    + +L+++LDS     + ++ D  + YFC+
Sbjct: 899  QLAYSCFSHLMKRMSQNFPNG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 957

Query: 552  RWLLIRFKREFSFLDILRLWEVMWT--ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEI 609
            RW L+ FKRE  + D+  +WEV+W    +   +F L +  A++E+ ++ I + +  F +I
Sbjct: 958  RWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDI 1017

Query: 610  LKHINELSMKIDVEDIL 626
            +K  NE +   D ++IL
Sbjct: 1018 IKFFNERAEHHDAQEIL 1034



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 1/71 (1%)

Query: 344 WTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTD 403
           W+K    +     ++ ++Q ++ GG+ H +RK  W FLLG++ +  +K+E  Q+      
Sbjct: 588 WSKYQKDKKNYKELELLRQ-VYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAA 646

Query: 404 EYFRMKLQWKS 414
            Y ++  +WK+
Sbjct: 647 RYQQVLAEWKA 657


>gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo
            sapiens]
          Length = 1032

 Score =  125 bits (314), Expect = 1e-28
 Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%)

Query: 433  IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 492
            IEKDV R DR N +Y    N  L  L +I+ +Y     ++GYVQGM DLL+PLL ++++E
Sbjct: 823  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 879

Query: 493  VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 551
              AF CF   M +M+QNF      M T    + +L+++LDS     + ++ D  + YFC+
Sbjct: 880  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 938

Query: 552  RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 609
            RW L+ FKRE  + D+  +WE +W     ++ H  L +  A++E  +  I+E +  F +I
Sbjct: 939  RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 998

Query: 610  LKHINELSMKIDVEDIL 626
            +K  NE++ + + + +L
Sbjct: 999  IKFFNEMAERHNTKQVL 1015



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 17/58 (29%), Positives = 31/58 (53%)

Query: 362 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQ 419
           ++I+ GG+   +RK  W FLLG++ +  T+ ER +  +  +     ++L   S S  Q
Sbjct: 556 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQ 613


>gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo
            sapiens]
          Length = 1093

 Score =  125 bits (314), Expect = 1e-28
 Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%)

Query: 433  IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 492
            IEKDV R DR N +Y    N  L  L +I+ +Y     ++GYVQGM DLL+PLL ++++E
Sbjct: 884  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 940

Query: 493  VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 551
              AF CF   M +M+QNF      M T    + +L+++LDS     + ++ D  + YFC+
Sbjct: 941  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 999

Query: 552  RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 609
            RW L+ FKRE  + D+  +WE +W     ++ H  L +  A++E  +  I+E +  F +I
Sbjct: 1000 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1059

Query: 610  LKHINELSMKIDVEDIL 626
            +K  NE++ + + + +L
Sbjct: 1060 IKFFNEMAERHNTKQVL 1076



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 18/65 (27%), Positives = 39/65 (60%), Gaps = 3/65 (4%)

Query: 362 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQW---KSISQE 418
           ++I+ GG+   +RK  W FLLG++ +  T+ ER ++ +Q    Y +   +W   ++I ++
Sbjct: 556 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAEWLGCEAIVRQ 615

Query: 419 QEKRN 423
           +E+ +
Sbjct: 616 RERES 620


>gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens]
          Length = 1087

 Score =  125 bits (314), Expect = 1e-28
 Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%)

Query: 433  IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 492
            IEKDV R DR N +Y    N  L  L +I+ +Y     ++GYVQGM DLL+PLL ++++E
Sbjct: 878  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 934

Query: 493  VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 551
              AF CF   M +M+QNF      M T    + +L+++LDS     + ++ D  + YFC+
Sbjct: 935  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 993

Query: 552  RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 609
            RW L+ FKRE  + D+  +WE +W     ++ H  L +  A++E  +  I+E +  F +I
Sbjct: 994  RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1053

Query: 610  LKHINELSMKIDVEDIL 626
            +K  NE++ + + + +L
Sbjct: 1054 IKFFNEMAERHNTKQVL 1070



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 17/58 (29%), Positives = 31/58 (53%)

Query: 362 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQ 419
           ++I+ GG+   +RK  W FLLG++ +  T+ ER +  +  +     ++L   S S  Q
Sbjct: 611 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQ 668


>gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens]
          Length = 1148

 Score =  125 bits (314), Expect = 1e-28
 Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%)

Query: 433  IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 492
            IEKDV R DR N +Y    N  L  L +I+ +Y     ++GYVQGM DLL+PLL ++++E
Sbjct: 939  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 995

Query: 493  VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 551
              AF CF   M +M+QNF      M T    + +L+++LDS     + ++ D  + YFC+
Sbjct: 996  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 1054

Query: 552  RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 609
            RW L+ FKRE  + D+  +WE +W     ++ H  L +  A++E  +  I+E +  F +I
Sbjct: 1055 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1114

Query: 610  LKHINELSMKIDVEDIL 626
            +K  NE++ + + + +L
Sbjct: 1115 IKFFNEMAERHNTKQVL 1131



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 18/65 (27%), Positives = 39/65 (60%), Gaps = 3/65 (4%)

Query: 362 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQW---KSISQE 418
           ++I+ GG+   +RK  W FLLG++ +  T+ ER ++ +Q    Y +   +W   ++I ++
Sbjct: 611 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAEWLGCEAIVRQ 670

Query: 419 QEKRN 423
           +E+ +
Sbjct: 671 RERES 675


>gi|40068063 TBC1 domain family, member 22B [Homo sapiens]
          Length = 505

 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 72/296 (24%), Positives = 134/296 (45%), Gaps = 36/296 (12%)

Query: 331 PVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDST 390
           P +  RE   LE++ + + S+    ++D +++  + G +   +R   W+ L GY P  + 
Sbjct: 176 PPMTVREKTRLEKFRQLLSSQNT--DLDELRKCSWPG-VPREVRPITWRLLSGYLP--AN 230

Query: 391 KEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQ 450
            E R    ++K +EYF    Q+     E+  +++    YR  I  D+ RT+     +  Q
Sbjct: 231 TERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDT----YRQ-IHIDIPRTNPLIPLF--Q 283

Query: 451 DNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYV---------MEN---------- 491
                 +   IL  + +     GYVQG++DL++P   V         +EN          
Sbjct: 284 QPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDM 343

Query: 492 ----EVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYL 547
               E D+FWC +  +D +  N+     G++ ++  L  L+  +D    ++    +  YL
Sbjct: 344 LRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYL 403

Query: 548 YFCFRWLLIRFKREFSFLDILRLWEVMWTELP-CTNFHLLLCCAILESEKQQIMEK 602
            F FRW+     RE      +RLW+   +E    ++FHL +C A L   +++I+++
Sbjct: 404 QFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDE 459


>gi|22507409 TBC1 domain family, member 22A [Homo sapiens]
          Length = 517

 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 77/296 (26%), Positives = 125/296 (42%), Gaps = 40/296 (13%)

Query: 368 GLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRL- 426
           G+   +R   WK L GY P +  +   T  +KQK  EYF        I    + RN  + 
Sbjct: 222 GIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQK--EYFAF------IEHYYDSRNDEVH 273

Query: 427 RDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLL 486
           +D    I  D+ R        + +      +   IL  + +     GYVQG++DL++P  
Sbjct: 274 QDTYRQIHIDIPRMSPEALILQPKVTE---IFERILFIWAIRHPASGYVQGINDLVTPFF 330

Query: 487 YVM------------------------ENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLI 522
            V                           E D +WC +  +D +  N+     G++ ++ 
Sbjct: 331 VVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVK 390

Query: 523 QLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELP-CT 581
            L  L+  +D     +L+  +  YL F FRW+     RE      +RLW+   +E    +
Sbjct: 391 MLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFS 450

Query: 582 NFHLLLCCAILESEKQQIMEKHYGFNEILKHINEL-SMKIDVEDI-LCKAEAISLQ 635
           +FHL +C A L   +++I+E+   F E+L  +  L +   D EDI L  AEA  L+
Sbjct: 451 HFHLYVCAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDISLLLAEAYRLK 505


>gi|190014603 TBC1 domain family, member 13 [Homo sapiens]
          Length = 400

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 51/186 (27%), Positives = 94/186 (50%), Gaps = 17/186 (9%)

Query: 461 ILMTYCMYDFDLGYVQGMSDLLSPLLYVMEN----------EVDAFWCFASYMDQMHQNF 510
           IL  Y   +  + YVQGM++++ PL Y              E D F+CF + M ++  NF
Sbjct: 214 ILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLMAEIRDNF 273

Query: 511 ----EEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLD 566
               ++   G+  ++ ++ + L+  D      L+ Q+    +F FRWL +   +EF   D
Sbjct: 274 IKSLDDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLSQEFLLPD 333

Query: 567 ILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDIL 626
           ++R+W+ ++ +    +F LL+CCA+L   ++Q++E  +  N  L     ++   DV  IL
Sbjct: 334 VIRIWDSLFADDNRFDFLLLVCCAMLMLIREQLLEGDFTVNMRLLQDYPIT---DVCQIL 390

Query: 627 CKAEAI 632
            KA+ +
Sbjct: 391 QKAKEL 396


>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
          Length = 828

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 59/248 (23%), Positives = 108/248 (43%), Gaps = 30/248 (12%)

Query: 333 VQRREPVSLE---EWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDS 389
           V+R++ + +E   +W K +    +  N +   + I++G +   LR + W  LL       
Sbjct: 63  VERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKG-IPLQLRGEVWALLL------- 114

Query: 390 TKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEG 449
              E  +++++  D Y ++K + +  S +  +           I+ DVNRT R +  +  
Sbjct: 115 ---EIPKMKEETRDLYSKLKHRARGCSPDIRQ-----------IDLDVNRTFRDHIMFRD 160

Query: 450 QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWC----FASYMDQ 505
           +       L  +L  Y +Y+ ++GY QGMS + + LL  M NE DAFW     F+     
Sbjct: 161 RYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYM-NEEDAFWALVKLFSGPKHA 219

Query: 506 MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFL 565
           MH  F +    +         +L    S    +L+SQ+    ++  +W    F     F 
Sbjct: 220 MHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFT 279

Query: 566 DILRLWEV 573
             LR+W++
Sbjct: 280 LNLRIWDI 287


>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
          Length = 845

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 59/248 (23%), Positives = 108/248 (43%), Gaps = 30/248 (12%)

Query: 333 VQRREPVSLE---EWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDS 389
           V+R++ + +E   +W K +    +  N +   + I++G +   LR + W  LL       
Sbjct: 80  VERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKG-IPLQLRGEVWALLL------- 131

Query: 390 TKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEG 449
              E  +++++  D Y ++K + +  S +  +           I+ DVNRT R +  +  
Sbjct: 132 ---EIPKMKEETRDLYSKLKHRARGCSPDIRQ-----------IDLDVNRTFRDHIMFRD 177

Query: 450 QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWC----FASYMDQ 505
           +       L  +L  Y +Y+ ++GY QGMS + + LL  M NE DAFW     F+     
Sbjct: 178 RYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYM-NEEDAFWALVKLFSGPKHA 236

Query: 506 MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFL 565
           MH  F +    +         +L    S    +L+SQ+    ++  +W    F     F 
Sbjct: 237 MHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFT 296

Query: 566 DILRLWEV 573
             LR+W++
Sbjct: 297 LNLRIWDI 304


>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
            [Homo sapiens]
          Length = 1168

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 63/262 (24%), Positives = 117/262 (44%), Gaps = 24/262 (9%)

Query: 344  WTKNIDSEGRI---LNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQ 400
            W K + + GR     +++ M   + +G   H  R + WKFL           E+  L+ Q
Sbjct: 774  WEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHH-RGEIWKFLA----------EQFHLKHQ 822

Query: 401  KTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHD 460
                 F  K Q K +  ++  +    + +  LI  D+ RT  T+ ++  Q   G + L++
Sbjct: 823  -----FPSKQQPKDVPYKELLKQLTSQQHAILI--DLGRTFPTHPYFSAQLGAGQLSLYN 875

Query: 461  ILMTYCMYDFDLGYVQGMSDLLS-PLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKT 519
            IL  Y + D ++GY QG+S +    LL++ E E      F  +   + + +   M  ++ 
Sbjct: 876  ILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQI 935

Query: 520  QLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELP 579
            Q+ QLS LL        ++LE  + G   +   W L  F  +F    + R++++++  L 
Sbjct: 936  QMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIF--LQ 993

Query: 580  CTNFHLLLCCAILESEKQQIME 601
             T     +  ++L S K  I++
Sbjct: 994  GTEVIFKVALSLLGSHKPLILQ 1015


>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
          Length = 963

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 76/346 (21%), Positives = 136/346 (39%), Gaps = 56/346 (16%)

Query: 289 STHQRPPSEM-ADFLSDAIPGLKINQQEEP----------------GFEVITRIDLGERP 331
           S  Q P  E+ A  L DA   L++  QE+P                GF  +   D  E+ 
Sbjct: 555 SEDQGPTREVIAQLLEDA---LQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEEKL 611

Query: 332 VVQRREP-------VSLEEWTKNIDSEGRILNVDNMKQM-------IFRGGLSHALRKQA 377
           V + R            +E +  +  E    +  N + M       + R G+ H  R + 
Sbjct: 612 VAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLIRAGIPHEHRSKV 671

Query: 378 WKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDV 437
           WK+ +         +  T+  K  T+      L  K++    EK+N   +     IE D+
Sbjct: 672 WKWCV---------DRHTRKFKDNTEPGHFQTLLQKAL----EKQNPASKQ----IELDL 714

Query: 438 NRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFW 497
            RT   NK Y    + G+  L ++L+ +   + D+GY QG++ L++  L  +E E DAFW
Sbjct: 715 LRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQE-DAFW 773

Query: 498 CFASYMD--QMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLL 555
           C  + ++       + + + G +        L+         + E     Y    F W L
Sbjct: 774 CLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFL 833

Query: 556 IRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIME 601
           + F        + ++W+    E P   F   L  A+ + ++++I++
Sbjct: 834 VVFVDSVVSDILFKIWDSFLYEGPKVIFRFAL--ALFKYKEEEILK 877


>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
          Length = 914

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 76/346 (21%), Positives = 136/346 (39%), Gaps = 56/346 (16%)

Query: 289 STHQRPPSEM-ADFLSDAIPGLKINQQEEP----------------GFEVITRIDLGERP 331
           S  Q P  E+ A  L DA   L++  QE+P                GF  +   D  E+ 
Sbjct: 555 SEDQGPTREVIAQLLEDA---LQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEEKL 611

Query: 332 VVQRREP-------VSLEEWTKNIDSEGRILNVDNMKQM-------IFRGGLSHALRKQA 377
           V + R            +E +  +  E    +  N + M       + R G+ H  R + 
Sbjct: 612 VAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLIRAGIPHEHRSKV 671

Query: 378 WKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDV 437
           WK+ +         +  T+  K  T+      L  K++    EK+N   +     IE D+
Sbjct: 672 WKWCV---------DRHTRKFKDNTEPGHFQTLLQKAL----EKQNPASKQ----IELDL 714

Query: 438 NRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFW 497
            RT   NK Y    + G+  L ++L+ +   + D+GY QG++ L++  L  +E E DAFW
Sbjct: 715 LRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQE-DAFW 773

Query: 498 CFASYMD--QMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLL 555
           C  + ++       + + + G +        L+         + E     Y    F W L
Sbjct: 774 CLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFL 833

Query: 556 IRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIME 601
           + F        + ++W+    E P   F   L  A+ + ++++I++
Sbjct: 834 VVFVDSVVSDILFKIWDSFLYEGPKVIFRFAL--ALFKYKEEEILK 877


>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
          Length = 1298

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 43/167 (25%), Positives = 80/167 (47%), Gaps = 3/167 (1%)

Query: 436  DVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP-LLYVMENEVD 494
            D+ RT  T+ ++  Q  PG + L ++L  Y + D ++GY QG+S +    LL++ E +  
Sbjct: 969  DLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAF 1028

Query: 495  AFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWL 554
                F  Y     + +   M  ++ Q+ QLS LL        ++LE  +     +   W 
Sbjct: 1029 EMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWF 1088

Query: 555  LIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIME 601
            L  F  +FS   + R++++++  L  T     +  ++L S++  IME
Sbjct: 1089 LTLFASQFSLGFVARVFDIIF--LQGTEVIFKVALSLLSSQETLIME 1133


>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
          Length = 336

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 56/238 (23%), Positives = 100/238 (42%), Gaps = 26/238 (10%)

Query: 366 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR 425
           R G+    R + W  L G            Q Q  +   Y+   LQ +        RN R
Sbjct: 66  RKGVPLEHRARVWMVLSG-----------AQAQMDQNPGYYHQLLQGE--------RNPR 106

Query: 426 LRDYRSLIEKDVNRTDRTNKFYEGQDNPGLI-LLHDILMTYCMYDFDLGYVQGMSDLLSP 484
           L D    I  D+NRT   N  +    +P L   L+++L+ Y  ++  +GY QGM+ +   
Sbjct: 107 LED---AIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGY 163

Query: 485 LLYVMENEVDAFWCFASYMDQ-MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQD 543
           L+ +  NE ++FW   + + + +   +   M G+KT    L  L+R       + +E   
Sbjct: 164 LILITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLG 223

Query: 544 SGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIME 601
             +     RW +  F        +LR+W+ ++ E     F + L   +++  ++ I+E
Sbjct: 224 VLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVAL--TLIKQHQELILE 279


>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
          Length = 508

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 82/370 (22%), Positives = 154/370 (41%), Gaps = 40/370 (10%)

Query: 281 DSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVS 340
           +SL G+  S  Q P +   D LS      + N   E   +    I +G +      E V 
Sbjct: 17  ESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFI-VGSQGAEGALEEVP 75

Query: 341 LE-------EWTKNIDSEGRILNVDNMK-QMIFRGGLSHALRKQAWKFLLGYFPWDSTKE 392
           LE       +W   +++  + +   + K ++  + G+  +LR +AW++L G        +
Sbjct: 76  LEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSG-------GK 128

Query: 393 ERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDN 452
            + Q    K DE          +S    K       +  +IE+D++R    ++ +  +  
Sbjct: 129 VKLQQNPGKFDEL--------DMSPGDPK-------WLDVIERDLHRQFPFHEMFVSRGG 173

Query: 453 PGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQ-MHQNFE 511
            G   L  +L  Y +Y  + GY Q  + + + LL  M  E  AFWC     ++ +   + 
Sbjct: 174 HGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAE-QAFWCLVQICEKYLPGYYS 232

Query: 512 EQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLW 571
           E+++ ++     L +LL+ +      +L  Q    L +   W +  F R   +  +LR+W
Sbjct: 233 EKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVW 292

Query: 572 EVMWTELPCTNFH---LLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCK 628
           ++ + E     F    +LL  A+   EK +  +  Y   E ++ +  LS KI  E  L +
Sbjct: 293 DMFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQY---ETIERLRSLSPKIMQEAFLVQ 349

Query: 629 AEAISLQMVK 638
            E + L + +
Sbjct: 350 -EVVELPVTE 358


>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
           sapiens]
          Length = 815

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 60/270 (22%), Positives = 111/270 (41%), Gaps = 44/270 (16%)

Query: 341 LEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQ 400
           L +W  N+ +  + L+       + + G+  ALR + W+ L G        + +  L + 
Sbjct: 517 LGKWHSNLGARPKGLST------LVKSGVPEALRAEVWQLLAG------CHDNQAMLDRY 564

Query: 401 KTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHD 460
           +        L  K  +QE            S+I +D++RT   + +++     G   L+ 
Sbjct: 565 RI-------LITKDSAQE------------SVITRDIHRTFPAHDYFKDTGGDGQESLYK 605

Query: 461 ILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYM------DQMHQNFEEQM 514
           I   Y +YD D+GY QG S L + LL  M  E  AF      M      D    NFE+  
Sbjct: 606 ICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEE-QAFCVLVKIMYDYGLRDLYRNNFED-- 662

Query: 515 QGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVM 574
             +  +  QL  L++       S+    +     +  +W L  F  +F    +  + +++
Sbjct: 663 --LHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLL 720

Query: 575 WTELPCTNFHLLLCCAILESEKQQIMEKHY 604
             E     FH+ L  A+L++ K+ +++  +
Sbjct: 721 LCEGLNIIFHVAL--ALLKTSKEDLLQADF 748


>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
          Length = 1069

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 68/304 (22%), Positives = 123/304 (40%), Gaps = 40/304 (13%)

Query: 303 SDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQ 362
           S  IP    + +EE   E +     G   V +      LE W + +      LNV   KQ
Sbjct: 503 SSVIPSPPEDDEEEDNDEPLLS---GSGDVSKECAEKILETWGELLSKWHLNLNV-RPKQ 558

Query: 363 M--IFRGGLSHALRKQAWKFLLGYFPWDSTKEE-RTQLQKQKTDEYFRMKLQWKSISQEQ 419
           +  + R G+  ALR + W+ L G    D   E+ R  + K+   +               
Sbjct: 559 LSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQD--------------- 603

Query: 420 EKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMS 479
                      S I +D+NRT   + +++     G   L+ I   Y +YD ++GY QG S
Sbjct: 604 -----------SAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQS 652

Query: 480 DLLSPLLYVMENEVDAFWCFASYMDQ--MHQNFEEQMQGMKTQLIQLSTLLR-LLDSGFC 536
            L + LL  M  E  AF      M    + + F++  + +  +  QL  L++  +   + 
Sbjct: 653 FLAAVLLLHMPEE-QAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYN 711

Query: 537 SYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEK 596
            +L+     ++Y   +W L  F  +F    +  + +++  E     F++ L   +L++ K
Sbjct: 712 HFLDISLEAHMY-ASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVAL--GLLKTSK 768

Query: 597 QQIM 600
             ++
Sbjct: 769 DDLL 772


>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
          Length = 749

 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 71/319 (22%), Positives = 123/319 (38%), Gaps = 36/319 (11%)

Query: 290 THQRPPSEMADFLSDAIPGLKINQQE--EPGFEVITRIDLGERPVVQRREPVSLEEWTKN 347
           T +   +E  +F  D   G ++ ++E  EPG  ++    L E    + R    LE +T N
Sbjct: 29  TQKEESAEQPEFYYDEF-GFRVYKEEGDEPGSSLLANSPLMEDAPQRLRWQAHLE-FTHN 86

Query: 348 IDSEG--------RILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQK 399
            D            +   + ++ ++   G+ H +R Q W  L G             LQK
Sbjct: 87  HDVGDLTWDKIAVSLPRSEKLRSLVL-AGIPHGMRPQLWMRLSG------------ALQK 133

Query: 400 QKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLH 459
           ++  E    ++   S + E              IEKD+ RT  +N  +    + G+  L 
Sbjct: 134 KRNSELSYREIVKNSSNDETIAAKQ--------IEKDLLRTMPSNACFASMGSIGVPRLR 185

Query: 460 DILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQM--HQNFEEQMQGM 517
            +L        ++GY QG   + + LL  +E E DAFW  ++ ++ +     F   + G+
Sbjct: 186 RVLRALAWLYPEIGYCQGTGMVAACLLLFLEEE-DAFWMMSAIIEDLLPASYFSTTLLGV 244

Query: 518 KTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTE 577
           +T    L  L+          L+  D         W L  F        +LR+W++ + E
Sbjct: 245 QTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYE 304

Query: 578 LPCTNFHLLLCCAILESEK 596
                F L L    L+ E+
Sbjct: 305 GSRVLFQLTLGMLHLKEEE 323


>gi|229577000 ecotropic viral integration site 5-like isoform 1
           [Homo sapiens]
          Length = 805

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 48/214 (22%), Positives = 96/214 (44%), Gaps = 6/214 (2%)

Query: 432 LIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMEN 491
           LI +D+ RT   ++F++GQD+ G  +L +++  Y + D ++GY QG + ++  LL  M  
Sbjct: 153 LIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPE 212

Query: 492 EVDAFWCFASYMDQ--MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYF 549
           E +AF  F   M +  + + F+  M  +   + Q   +L+       ++  SQ      +
Sbjct: 213 E-EAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMY 271

Query: 550 CFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY-GFNE 608
              W L  F   F      R++++   E     F + L  A+L+  + ++M+    G ++
Sbjct: 272 ASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGL--ALLQVNQAELMQLDMEGMSQ 329

Query: 609 ILKHINELSMKIDVEDILCKAEAISLQMVKCKEL 642
             + +         + ++ KA  +     K K L
Sbjct: 330 YFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRL 363


>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
           sapiens]
          Length = 794

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 48/214 (22%), Positives = 96/214 (44%), Gaps = 6/214 (2%)

Query: 432 LIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMEN 491
           LI +D+ RT   ++F++GQD+ G  +L +++  Y + D ++GY QG + ++  LL  M  
Sbjct: 153 LIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPE 212

Query: 492 EVDAFWCFASYMDQ--MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYF 549
           E +AF  F   M +  + + F+  M  +   + Q   +L+       ++  SQ      +
Sbjct: 213 E-EAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMY 271

Query: 550 CFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY-GFNE 608
              W L  F   F      R++++   E     F + L  A+L+  + ++M+    G ++
Sbjct: 272 ASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGL--ALLQVNQAELMQLDMEGMSQ 329

Query: 609 ILKHINELSMKIDVEDILCKAEAISLQMVKCKEL 642
             + +         + ++ KA  +     K K L
Sbjct: 330 YFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRL 363


>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
          Length = 808

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 57/262 (21%), Positives = 102/262 (38%), Gaps = 24/262 (9%)

Query: 366 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR 425
           R G+  +LR +AW++L       S  +E  +    K +E  R     K            
Sbjct: 358 RKGIPSSLRAKAWQYL-------SNSKELLEQNPGKFEELERAPGDPK------------ 398

Query: 426 LRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPL 485
              +  +IEKD++R    ++ +  +   G   L+ IL  Y +Y  D GY Q  + + + L
Sbjct: 399 ---WLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVL 455

Query: 486 LYVMENEVDAFWCFASYMDQ-MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS 544
           L  M  E  AFWC     D+ +   +   ++ ++        LLR        +L  Q  
Sbjct: 456 LMHMPAE-QAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRI 514

Query: 545 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY 604
             + +   W +  F R   +  +LR+W++ + E     F + L          + +    
Sbjct: 515 DPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQ 574

Query: 605 GFNEILKHINELSMKIDVEDIL 626
           G  E ++ +  L  +   ED L
Sbjct: 575 GMYETMEQLRNLPQQCMQEDFL 596


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,786,717
Number of Sequences: 37866
Number of extensions: 1286297
Number of successful extensions: 3947
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 3813
Number of HSP's gapped (non-prelim): 113
length of query: 713
length of database: 18,247,518
effective HSP length: 109
effective length of query: 604
effective length of database: 14,120,124
effective search space: 8528554896
effective search space used: 8528554896
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.