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Search of human proteins with 115511026
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115511026 acyl-CoA synthetase medium-chain family member 1
[Homo sapiens]
(577 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115511026 acyl-CoA synthetase medium-chain family member 1 [H... 1198 0.0
gi|38505220 acyl-CoA synthetase medium-chain family member 5 [Ho... 667 0.0
gi|58082049 acyl-CoA synthetase medium-chain family member 2A [H... 666 0.0
gi|157311624 acyl-CoA synthetase medium-chain family member 2B [... 664 0.0
gi|157311622 acyl-CoA synthetase medium-chain family member 2B [... 664 0.0
gi|122937307 acyl-CoA synthetase medium-chain family member 4 [H... 642 0.0
gi|42544132 SA hypertension-associated homolog isoform 1 [Homo s... 628 e-180
gi|239756507 PREDICTED: similar to Acyl-coenzyme A synthetase AC... 609 e-174
gi|239756505 PREDICTED: similar to Acyl-coenzyme A synthetase AC... 609 e-174
gi|42544134 SA hypertension-associated homolog isoform 2 [Homo s... 396 e-110
gi|195947378 acyl-coenzyme A synthetase ACSM6, mitochondrial [Ho... 379 e-105
gi|28416953 acyl-CoA synthetase short-chain family member 1 [Hom... 177 3e-44
gi|13375727 acyl-CoA synthetase short-chain family member 3 [Hom... 167 2e-41
gi|8923896 acyl-CoA synthetase short-chain family member 2 isofo... 164 2e-40
gi|253970489 acyl-CoA synthetase short-chain family member 2 iso... 163 4e-40
gi|156151445 acyl-CoA synthetase family member 2 [Homo sapiens] 117 3e-26
gi|187761345 acyl-CoA synthetase family member 3 [Homo sapiens] 110 3e-24
gi|187761343 acyl-CoA synthetase family member 3 [Homo sapiens] 110 3e-24
gi|38524616 solute carrier family 27, member 1 [Homo sapiens] 88 2e-17
gi|13236579 solute carrier family 27 member 3 [Homo sapiens] 81 2e-15
gi|227499619 solute carrier family 27 (fatty acid transporter), ... 72 1e-12
gi|40807357 solute carrier family 27 (fatty acid transporter), m... 71 3e-12
gi|209529739 hypothetical protein LOC100132247 [Homo sapiens] 65 2e-10
gi|239745501 PREDICTED: similar to acyl-CoA synthetase medium-ch... 65 2e-10
gi|157074225 nuclear pore complex interacting protein-like 3 [Ho... 65 2e-10
gi|239745482 PREDICTED: hypothetical protein [Homo sapiens] 64 3e-10
gi|239745430 PREDICTED: hypothetical protein XP_002343465 [Homo ... 63 6e-10
gi|239745418 PREDICTED: similar to GPS, PLAT and transmembrane d... 63 6e-10
gi|239745416 PREDICTED: similar to GPS, PLAT and transmembrane d... 63 6e-10
gi|13325057 solute carrier family 27 (fatty acid transporter), m... 62 1e-09
>gi|115511026 acyl-CoA synthetase medium-chain family member 1 [Homo
sapiens]
Length = 577
Score = 1198 bits (3100), Expect = 0.0
Identities = 577/577 (100%), Positives = 577/577 (100%)
Query: 1 MQWLMRFRTLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWA 60
MQWLMRFRTLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWA
Sbjct: 1 MQWLMRFRTLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWA 60
Query: 61 QKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPR 120
QKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPR
Sbjct: 61 QKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPR 120
Query: 121 VPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCP 180
VPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCP
Sbjct: 121 VPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCP 180
Query: 181 SLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSH 240
SLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSH
Sbjct: 181 SLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSH 240
Query: 241 GLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTK 300
GLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTK
Sbjct: 241 GLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTK 300
Query: 301 VIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTG 360
VIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTG
Sbjct: 301 VIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTG 360
Query: 361 LLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNIGIRI 420
LLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNIGIRI
Sbjct: 361 LLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNIGIRI 420
Query: 421 KPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIG 480
KPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIG
Sbjct: 421 KPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIG 480
Query: 481 PAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSV 540
PAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSV
Sbjct: 481 PAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSV 540
Query: 541 TAPYKYPRKVEFVSELPKTITGKIERKELRKKETGQM 577
TAPYKYPRKVEFVSELPKTITGKIERKELRKKETGQM
Sbjct: 541 TAPYKYPRKVEFVSELPKTITGKIERKELRKKETGQM 577
>gi|38505220 acyl-CoA synthetase medium-chain family member 5 [Homo
sapiens]
Length = 579
Score = 667 bits (1721), Expect = 0.0
Identities = 325/579 (56%), Positives = 415/579 (71%), Gaps = 12/579 (2%)
Query: 1 MQWLMRFRTLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWA 60
+Q L R G H PAP + + ++ + A VPE FNFA VLD W+
Sbjct: 10 LQALRNSRAFCGSHGK-----PAPLPVPQKIVATWEAISLGRQLVPEYFNFAHDVLDVWS 64
Query: 61 QKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPR 120
+ E+ G R PNPAFWWVNG G E+KWSF E+G +R+ ANV CGLQ GD + L+LPR
Sbjct: 65 RLEEAGHRPPNPAFWWVNGTGAEIKWSFEELGKQSRKAANVLGGACGLQPGDRMMLVLPR 124
Query: 121 VPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCP 180
+PEWWLV+V CMRTG + IP L KD+ YRLQ S+AK I+T D+LA VD+I+++CP
Sbjct: 125 LPEWWLVSVACMRTGTVMIPGVTQLTEKDLKYRLQASRAKSIITSDSLAPRVDAISAECP 184
Query: 181 SLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHS- 239
SL+TKLLVSD SR GWL+FR L++ AS EH C+++K+ DP+ I+FTSGTTG PKM +HS
Sbjct: 185 SLQTKLLVSDSSRPGWLNFRELLREASTEHNCMRTKSRDPLAIYFTSGTTGAPKMVEHSQ 244
Query: 240 --HGLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQF 297
+GL S R+ +L SD+ W +D+GW+ A WTL W G +F+H LP+
Sbjct: 245 SSYGLGFVAS---GRRWVALTESDIFWNTTDTGWVKAA-WTLFSAWPNGSCIFVHELPRV 300
Query: 298 DTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWKR 357
D KVI+ TL K+PI V +I+R+++Q+D T +F +L HC TGGE + P +E+WK
Sbjct: 301 DAKVILNTLSKFPITTLCCVPTIFRLLVQEDLTRYQFQSLRHCLTGGEALNPDVREKWKH 360
Query: 358 RTGLLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNIG 417
+TG+ LYE YGQSET +ICA GMKIK G MGKA+PPYDVQ++DD+G++LPP EGN+
Sbjct: 361 QTGVELYEGYGQSETVVICANPKGMKIKSGSMGKASPPYDVQIVDDEGNVLPPGEEGNVA 420
Query: 418 IRIKPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGY 477
+RI+P RP F CY +PEKTA E GDFY TGDR +MD++GY F+GR+DD+IN+S Y
Sbjct: 421 VRIRPTRPFCFFNCYLDNPEKTAASEQGDFYITGDRARMDKDGYFWFMGRNDDVINSSSY 480
Query: 478 RIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHV 537
RIGP EVESAL EHPAV ESAVV SPDPIRGEVVKAFIVLTP + SHD + LT+ELQ+HV
Sbjct: 481 RIGPVEVESALAEHPAVLESAVVSSPDPIRGEVVKAFIVLTPAYSSHDPEALTRELQEHV 540
Query: 538 KSVTAPYKYPRKVEFVSELPKTITGKIERKELRKKETGQ 576
K VTAPYKYPRKV FVSELPKT++GKI+R +LR +E G+
Sbjct: 541 KRVTAPYKYPRKVAFVSELPKTVSGKIQRSKLRSQEWGK 579
>gi|58082049 acyl-CoA synthetase medium-chain family member 2A [Homo
sapiens]
Length = 577
Score = 666 bits (1719), Expect = 0.0
Identities = 321/577 (55%), Positives = 422/577 (73%), Gaps = 14/577 (2%)
Query: 1 MQWLMRFR---TLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLD 57
M WL + + TLWG S ++ QL + +W EVP +FNFAS VLD
Sbjct: 1 MHWLRKVQGLCTLWGTQMSSRTLYINSRQLV--------SLQWGHQEVPAKFNFASDVLD 52
Query: 58 YWAQKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALM 117
+WA EK GKR P+PA WWVNG+G E+ W+FRE+ + +++ ANV + CGLQ+GD +A++
Sbjct: 53 HWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVV 112
Query: 118 LPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIAS 177
LPRVPEWWLV +GC+R G+IF+P TI +K+ DILYRLQ+SKAK IV D + EVD++AS
Sbjct: 113 LPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVAS 172
Query: 178 QCPSLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAK 237
+CPSL+ KLLVS+ S +GWL+F+ L+ AS H CV++ + + I+FTSGT+G PKMA+
Sbjct: 173 ECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAE 232
Query: 238 HSHG-LALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQ 296
HS+ L L+ L+ SD+ W +SD+GWI+ + +L+EPW G F+H LP+
Sbjct: 233 HSYSSLGLKAKMDAG--WTGLQASDIMWTISDTGWILNILCSLMEPWALGACTFVHLLPK 290
Query: 297 FDTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWK 356
FD VI++TL YPI G +YRM+LQQD +S +FP L++C T GE +LP+ E W+
Sbjct: 291 FDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCVTVGESLLPETLENWR 350
Query: 357 RRTGLLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNI 416
+TGL + E+YGQ+ETGL C MKIKPG+MG A YDVQ+IDDKG++LPP TEG+I
Sbjct: 351 AQTGLDIRESYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQIIDDKGNVLPPGTEGDI 410
Query: 417 GIRIKPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASG 476
GIR+KP+RP+ +F Y +P+KTA GDF+ GDRG DE+GY F+GR+DDIIN+SG
Sbjct: 411 GIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRADDIINSSG 470
Query: 477 YRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQH 536
YRIGP+EVE+AL+EHPAV E+AV+ SPDP+RGEVVKAF+VL QFLSHD +QLTKELQQH
Sbjct: 471 YRIGPSEVENALMEHPAVVETAVISSPDPVRGEVVKAFVVLASQFLSHDPEQLTKELQQH 530
Query: 537 VKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKKE 573
VKSVTAPYKYPRK+EFV LPKT+TGKI+R +LR KE
Sbjct: 531 VKSVTAPYKYPRKIEFVLNLPKTVTGKIQRAKLRDKE 567
>gi|157311624 acyl-CoA synthetase medium-chain family member 2B
[Homo sapiens]
Length = 577
Score = 664 bits (1714), Expect = 0.0
Identities = 320/577 (55%), Positives = 421/577 (72%), Gaps = 14/577 (2%)
Query: 1 MQWLMRFR---TLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLD 57
M WL + + TLWG S ++ QL + +W EVP +FNFAS VLD
Sbjct: 1 MHWLRKVQGLCTLWGTQMSSRTLYINSRQLV--------SLQWGHQEVPAKFNFASDVLD 52
Query: 58 YWAQKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALM 117
+WA EK GKR P+PA WWVNG+G E+ W+FRE+ + +++ AN+ + CGLQ+GD +A+M
Sbjct: 53 HWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANILSGACGLQRGDRVAVM 112
Query: 118 LPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIAS 177
LPRVPEWWLV +GC+R G+IF+P TI +K+ DILYRLQ+SKAK IV D + EVD++AS
Sbjct: 113 LPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVAS 172
Query: 178 QCPSLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAK 237
+CPSL+ KLLVS+ S +GWL+F+ L+ AS H CV++ + + I+FTSGT+G PKMA+
Sbjct: 173 ECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAE 232
Query: 238 HSHG-LALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQ 296
HS+ L L+ L+ SD+ W +SD+GWI+ + +L+E WT G F+H LP+
Sbjct: 233 HSYSSLGLKAKMDAG--WTGLQASDIMWTISDTGWILNILGSLLESWTLGACTFVHLLPK 290
Query: 297 FDTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWK 356
FD VI++TL YPI G +YRM+LQQD +S +FP L++C GGE +LP+ E W+
Sbjct: 291 FDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCLAGGESLLPETLENWR 350
Query: 357 RRTGLLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNI 416
+TGL + E YGQ+ETGL C MKIKPG+MG A YDVQVIDDKG++LPP TEG+I
Sbjct: 351 AQTGLDIREFYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQVIDDKGNVLPPGTEGDI 410
Query: 417 GIRIKPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASG 476
GIR+KP+RP+ +F Y +P+KTA GDF+ GDRG DE+GY F+GR+DDIIN+SG
Sbjct: 411 GIRVKPIRPIGIFSGYVENPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRADDIINSSG 470
Query: 477 YRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQH 536
YRIGP+EVE+AL++HPAV E+AV+ SPDP+RGEVVKAF++L QFLSHD +QLTKELQQH
Sbjct: 471 YRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQFLSHDPEQLTKELQQH 530
Query: 537 VKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKKE 573
VKSVTAPYKYPRK+EFV LPKT+TGKI+R +LR KE
Sbjct: 531 VKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLRDKE 567
>gi|157311622 acyl-CoA synthetase medium-chain family member 2B
[Homo sapiens]
Length = 577
Score = 664 bits (1714), Expect = 0.0
Identities = 320/577 (55%), Positives = 421/577 (72%), Gaps = 14/577 (2%)
Query: 1 MQWLMRFR---TLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLD 57
M WL + + TLWG S ++ QL + +W EVP +FNFAS VLD
Sbjct: 1 MHWLRKVQGLCTLWGTQMSSRTLYINSRQLV--------SLQWGHQEVPAKFNFASDVLD 52
Query: 58 YWAQKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALM 117
+WA EK GKR P+PA WWVNG+G E+ W+FRE+ + +++ AN+ + CGLQ+GD +A+M
Sbjct: 53 HWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANILSGACGLQRGDRVAVM 112
Query: 118 LPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIAS 177
LPRVPEWWLV +GC+R G+IF+P TI +K+ DILYRLQ+SKAK IV D + EVD++AS
Sbjct: 113 LPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVAS 172
Query: 178 QCPSLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAK 237
+CPSL+ KLLVS+ S +GWL+F+ L+ AS H CV++ + + I+FTSGT+G PKMA+
Sbjct: 173 ECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAE 232
Query: 238 HSHG-LALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQ 296
HS+ L L+ L+ SD+ W +SD+GWI+ + +L+E WT G F+H LP+
Sbjct: 233 HSYSSLGLKAKMDAG--WTGLQASDIMWTISDTGWILNILGSLLESWTLGACTFVHLLPK 290
Query: 297 FDTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWK 356
FD VI++TL YPI G +YRM+LQQD +S +FP L++C GGE +LP+ E W+
Sbjct: 291 FDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCLAGGESLLPETLENWR 350
Query: 357 RRTGLLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNI 416
+TGL + E YGQ+ETGL C MKIKPG+MG A YDVQVIDDKG++LPP TEG+I
Sbjct: 351 AQTGLDIREFYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQVIDDKGNVLPPGTEGDI 410
Query: 417 GIRIKPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASG 476
GIR+KP+RP+ +F Y +P+KTA GDF+ GDRG DE+GY F+GR+DDIIN+SG
Sbjct: 411 GIRVKPIRPIGIFSGYVENPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRADDIINSSG 470
Query: 477 YRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQH 536
YRIGP+EVE+AL++HPAV E+AV+ SPDP+RGEVVKAF++L QFLSHD +QLTKELQQH
Sbjct: 471 YRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQFLSHDPEQLTKELQQH 530
Query: 537 VKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKKE 573
VKSVTAPYKYPRK+EFV LPKT+TGKI+R +LR KE
Sbjct: 531 VKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLRDKE 567
>gi|122937307 acyl-CoA synthetase medium-chain family member 4 [Homo
sapiens]
Length = 580
Score = 642 bits (1657), Expect = 0.0
Identities = 317/568 (55%), Positives = 401/568 (70%), Gaps = 2/568 (0%)
Query: 7 FRTLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWAQKEKEG 66
FR +W +H +L++F A + +P+ FNFA+ VLD W+QKEK G
Sbjct: 10 FRFIWLTKPPGRRLHKDHQLWTPLTLADFEAINRCNRPLPKNFNFAADVLDQWSQKEKTG 69
Query: 67 KRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWWL 126
+R NPA WWVNG+GDEVKWSFRE+G L+R+ ANV T+ CGLQ+GD LA++LPR+PEWWL
Sbjct: 70 ERPANPALWWVNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEWWL 129
Query: 127 VAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCPSLKTKL 186
V V C+RTGIIF+P TI L AKDILYRL+ SKAK IV + +A V+SI +CP LKTKL
Sbjct: 130 VNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASEEVAPAVESIVLECPDLKTKL 189
Query: 187 LVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSHG-LALQ 245
LVS S GWL F+ L + AS EH+CV++ + +PM I+FTSGTTGFPKMA+HS L +
Sbjct: 190 LVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIG 249
Query: 246 PSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTKVIIQT 305
+ G R LK+SD+ W +SD+GW+ A I ++ W G VF+H + QFDT + T
Sbjct: 250 FTLCG-RYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQFDTDTFLDT 308
Query: 306 LLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTGLLLYE 365
L YPI ++YRM++Q+D +F +L HC TGGE + P+ E+W+ +TGL LYE
Sbjct: 309 LTTYPITTLCSPPTVYRMLVQKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTGLELYE 368
Query: 366 NYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNIGIRIKPVRP 425
YGQ+E G+ICA G +IKPG MGK PYDVQ+ID+ G++LPP EG I +R+KP RP
Sbjct: 369 GYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIALRLKPTRP 428
Query: 426 VSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVE 485
F Y +P+KTA GDFY TGDRG MD +GY F+GR+DD+I +SGYRIGP EVE
Sbjct: 429 FCFFSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGYFWFVGRADDVIISSGYRIGPFEVE 488
Query: 486 SALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYK 545
SAL+EHPAV ESAVV SPD IRGEVVKAF+VL F S++ ++LT ELQ HVK TAPYK
Sbjct: 489 SALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQDHVKKSTAPYK 548
Query: 546 YPRKVEFVSELPKTITGKIERKELRKKE 573
YPRKVEFV ELPKTITGKI+R LR +E
Sbjct: 549 YPRKVEFVQELPKTITGKIKRNVLRDQE 576
>gi|42544132 SA hypertension-associated homolog isoform 1 [Homo
sapiens]
Length = 586
Score = 628 bits (1620), Expect = e-180
Identities = 299/532 (56%), Positives = 385/532 (72%), Gaps = 6/532 (1%)
Query: 45 VPEEFNFASYVLDYWAQKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQ 104
+PE FNFA VLD W KEK GK+ NPAFWW+N G+E++WSF E+G L+R+ AN+ ++
Sbjct: 54 IPEYFNFAKDVLDQWTDKEKAGKKPSNPAFWWINRNGEEMRWSFEELGSLSRKFANILSE 113
Query: 105 TCGLQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVT 164
C LQ+GD + L+LPRVPEWWL V C+RTG + IP T L KDILYRLQ SKA I+T
Sbjct: 114 ACSLQRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKANCIIT 173
Query: 165 IDALASEVDSIASQCPSLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIF 224
D LA VD++AS+C +L +KL+VS++SREGW + + L+K AS HTCVK+K + M IF
Sbjct: 174 NDVLAPAVDAVASKCENLHSKLIVSENSREGWGNLKELMKHASDSHTCVKTKHNEIMAIF 233
Query: 225 FTSGTTGFPKMAKHSH---GLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVE 281
FTSGT+G+PKM H+H GL L + R L SDV W SD+GW + ++
Sbjct: 234 FTSGTSGYPKMTAHTHSSFGLGLSVN---GRFWLDLTPSDVMWNTSDTGWAKSAWSSVFS 290
Query: 282 PWTAGCTVFIHHLPQFDTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCY 341
PW G VF HHLP+F+ I+QTL KYPI F ++YRM++Q D TS +F +L+HC
Sbjct: 291 PWIQGACVFTHHLPRFEPTSILQTLSKYPITVFCSAPTVYRMLVQNDITSYKFKSLKHCV 350
Query: 342 TGGEVVLPKDQEEWKRRTGLLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVI 401
+ GE + P E+W+ +TGL +YE YGQ+ET LIC + GMKIKPG MGK +P +DV+++
Sbjct: 351 SAGEPITPDVTEKWRNKTGLDIYEGYGQTETVLICGNFKGMKIKPGSMGKPSPAFDVKIV 410
Query: 402 DDKGSILPPNTEGNIGIRIKPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGY 461
D G++LPP EG+IGI++ P RP LF Y +P KTA G+FY TGDRG MD++GY
Sbjct: 411 DVNGNVLPPGQEGDIGIQVLPNRPFGLFTHYVDNPSKTASTLRGNFYITGDRGYMDKDGY 470
Query: 462 ICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQF 521
F+ R+DD+I +SGYRIGP EVE+AL EHP+VAESAVV SPDPIRGEVVKAF+VL P +
Sbjct: 471 FWFVARADDVILSSGYRIGPFEVENALNEHPSVAESAVVSSPDPIRGEVVKAFVVLNPDY 530
Query: 522 LSHDKDQLTKELQQHVKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKKE 573
SHD++QL KE+Q+HVK TAPYKYPRKVEF+ ELPKTI+GK +R ELRKKE
Sbjct: 531 KSHDQEQLIKEIQEHVKKTTAPYKYPRKVEFIQELPKTISGKTKRNELRKKE 582
>gi|239756507 PREDICTED: similar to Acyl-coenzyme A synthetase
ACSM2B, mitochondrial isoform 2 [Homo sapiens]
Length = 571
Score = 609 bits (1571), Expect = e-174
Identities = 305/578 (52%), Positives = 405/578 (70%), Gaps = 22/578 (3%)
Query: 1 MQWLMRFR---TLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLD 57
M WL + + TLWG S ++ QL + +W EVP +FNFAS VLD
Sbjct: 1 MHWLRKVQGLCTLWGTQMSSRTLYINSRQLV--------SLQWGHQEVPAKFNFASDVLD 52
Query: 58 YWAQKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALM 117
+WA EK GKR P+PA WWVNG+G E+ W+FRE+ + +++ ANV + CGLQ+GD +A+M
Sbjct: 53 HWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVM 112
Query: 118 LPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIAS 177
LPRVPEWWLV +GC+R G+IF+P TI +K+ DILYRLQ+SKAK IV D + EVD++AS
Sbjct: 113 LPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVAS 172
Query: 178 QCPSLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAK 237
+CPSL+ KLLVS+ S +GWL+F+ L+ AS H CV++ + + I+FTSGT+G PKMA+
Sbjct: 173 ECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAE 232
Query: 238 HSH-GLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQ 296
HS+ L L+ L+ SD+ W +SD+GWI+ + +L+E WT G F+H LP+
Sbjct: 233 HSYSSLGLKAKMDAG--WTGLQASDIMWTISDTGWILNILGSLLESWTLGACTFVHLLPK 290
Query: 297 FDTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWK 356
FD VI++TL YPI G +YRM+LQQD +S +FP L++C GGE +LP+ E W+
Sbjct: 291 FDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCLAGGESLLPETLENWR 350
Query: 357 RRTGLLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNI 416
+TGL + E YGQ+ETGL C MKIKPG+MG A YDVQVI + G++
Sbjct: 351 AQTGLDIREFYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQVI---AFVHGSPRAGDL 407
Query: 417 GIRIKPVRPVSLFMC-YEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINAS 475
G ++L C ++ +P+KTA GDF+ GDRG DE+GY F+GR+DDIIN+S
Sbjct: 408 GF----AGTMTLSFCGHQENPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRADDIINSS 463
Query: 476 GYRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQ 535
GYRIGP+EVE+AL++HPAV E+AV+ SPDP+RGEVVKAF++L QFLSHD +QLTKELQQ
Sbjct: 464 GYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQFLSHDPEQLTKELQQ 523
Query: 536 HVKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKKE 573
HVKSVTAPYKYPRK+EFV LPKT+TGKI+R +LR KE
Sbjct: 524 HVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLRDKE 561
>gi|239756505 PREDICTED: similar to Acyl-coenzyme A synthetase
ACSM2B, mitochondrial isoform 1 [Homo sapiens]
Length = 571
Score = 609 bits (1571), Expect = e-174
Identities = 305/578 (52%), Positives = 405/578 (70%), Gaps = 22/578 (3%)
Query: 1 MQWLMRFR---TLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLD 57
M WL + + TLWG S ++ QL + +W EVP +FNFAS VLD
Sbjct: 1 MHWLRKVQGLCTLWGTQMSSRTLYINSRQLV--------SLQWGHQEVPAKFNFASDVLD 52
Query: 58 YWAQKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALM 117
+WA EK GKR P+PA WWVNG+G E+ W+FRE+ + +++ ANV + CGLQ+GD +A+M
Sbjct: 53 HWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVM 112
Query: 118 LPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIAS 177
LPRVPEWWLV +GC+R G+IF+P TI +K+ DILYRLQ+SKAK IV D + EVD++AS
Sbjct: 113 LPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVAS 172
Query: 178 QCPSLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAK 237
+CPSL+ KLLVS+ S +GWL+F+ L+ AS H CV++ + + I+FTSGT+G PKMA+
Sbjct: 173 ECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAE 232
Query: 238 HSH-GLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQ 296
HS+ L L+ L+ SD+ W +SD+GWI+ + +L+E WT G F+H LP+
Sbjct: 233 HSYSSLGLKAKMDAG--WTGLQASDIMWTISDTGWILNILGSLLESWTLGACTFVHLLPK 290
Query: 297 FDTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWK 356
FD VI++TL YPI G +YRM+LQQD +S +FP L++C GGE +LP+ E W+
Sbjct: 291 FDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCLAGGESLLPETLENWR 350
Query: 357 RRTGLLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNI 416
+TGL + E YGQ+ETGL C MKIKPG+MG A YDVQVI + G++
Sbjct: 351 AQTGLDIREFYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQVI---AFVHGSPRAGDL 407
Query: 417 GIRIKPVRPVSLFMC-YEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINAS 475
G ++L C ++ +P+KTA GDF+ GDRG DE+GY F+GR+DDIIN+S
Sbjct: 408 GF----AGTMTLSFCGHQENPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRADDIINSS 463
Query: 476 GYRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQ 535
GYRIGP+EVE+AL++HPAV E+AV+ SPDP+RGEVVKAF++L QFLSHD +QLTKELQQ
Sbjct: 464 GYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQFLSHDPEQLTKELQQ 523
Query: 536 HVKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKKE 573
HVKSVTAPYKYPRK+EFV LPKT+TGKI+R +LR KE
Sbjct: 524 HVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLRDKE 561
>gi|42544134 SA hypertension-associated homolog isoform 2 [Homo
sapiens]
Length = 438
Score = 396 bits (1017), Expect = e-110
Identities = 187/359 (52%), Positives = 247/359 (68%), Gaps = 6/359 (1%)
Query: 45 VPEEFNFASYVLDYWAQKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQ 104
+PE FNFA VLD W KEK GK+ NPAFWW+N G+E++WSF E+G L+R+ AN+ ++
Sbjct: 54 IPEYFNFAKDVLDQWTDKEKAGKKPSNPAFWWINRNGEEMRWSFEELGSLSRKFANILSE 113
Query: 105 TCGLQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVT 164
C LQ+GD + L+LPRVPEWWL V C+RTG + IP T L KDILYRLQ SKA I+T
Sbjct: 114 ACSLQRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKANCIIT 173
Query: 165 IDALASEVDSIASQCPSLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIF 224
D LA VD++AS+C +L +KL+VS++SREGW + + L+K AS HTCVK+K + M IF
Sbjct: 174 NDVLAPAVDAVASKCENLHSKLIVSENSREGWGNLKELMKHASDSHTCVKTKHNEIMAIF 233
Query: 225 FTSGTTGFPKMAKHSH---GLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVE 281
FTSGT+G+PKM H+H GL L + R L SDV W SD+GW + ++
Sbjct: 234 FTSGTSGYPKMTAHTHSSFGLGLSVN---GRFWLDLTPSDVMWNTSDTGWAKSAWSSVFS 290
Query: 282 PWTAGCTVFIHHLPQFDTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCY 341
PW G VF HHLP+F+ I+QTL KYPI F ++YRM++Q D TS +F +L+HC
Sbjct: 291 PWIQGACVFTHHLPRFEPTSILQTLSKYPITVFCSAPTVYRMLVQNDITSYKFKSLKHCV 350
Query: 342 TGGEVVLPKDQEEWKRRTGLLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQV 400
+ GE + P E+W+ +TGL +YE YGQ+ET LIC + GMKIKPG MGK +P +DV+V
Sbjct: 351 SAGEPITPDVTEKWRNKTGLDIYEGYGQTETVLICGNFKGMKIKPGSMGKPSPAFDVKV 409
>gi|195947378 acyl-coenzyme A synthetase ACSM6, mitochondrial [Homo
sapiens]
Length = 480
Score = 379 bits (972), Expect = e-105
Identities = 195/437 (44%), Positives = 277/437 (63%), Gaps = 3/437 (0%)
Query: 45 VPEEFNFASYVLDYWAQKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQ 104
V + FNFA VLD W+Q EK+G RGP PA W V+ +G+E KWSF M L+++ A++ +
Sbjct: 45 VSQNFNFAKDVLDQWSQLEKDGLRGPYPALWKVSAKGEEDKWSFERMTQLSKKAASILSD 104
Query: 105 TCGLQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVT 164
TC L GD L ++LP PE + + + C+R GI F+P + L AK I Y+L++SKA+ IV
Sbjct: 105 TCALSHGDRLMIILPPTPEAYWICLACVRLGITFVPGSPQLTAKKIRYQLRMSKAQCIVA 164
Query: 165 IDALASEVDSIASQCPSLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIF 224
+A+A V+S S CP+LKTKLLVSD S +GWLDF+ L++ A P+ T +++K+ DPM IF
Sbjct: 165 NEAMAPVVNSAVSDCPTLKTKLLVSDKSYDGWLDFKKLIQVAPPKQTYMRTKSQDPMAIF 224
Query: 225 FTSGTTGFPKMAKHS-HGLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPW 283
FT GTTG PKM ++S +GL + S SR+ L+ +DV W L D+ ++ ++ W
Sbjct: 225 FTKGTTGAPKMVEYSQYGLGMGFS-QASRRWMDLQPTDVLWSLGDAFGGSLSLSAVLGTW 283
Query: 284 TAGCTVFIHHLPQFDTKVIIQTLLKYPINHFWGVSSIYRMILQQD-FTSIRFPALEHCYT 342
G VF+ H+P F + ++ L ++PI +Y+ +LQ FTS RF +L+ C
Sbjct: 284 FQGACVFLCHMPTFCPETVLNVLSRFPITTLSANPEMYQELLQHKCFTSYRFKSLKQCVA 343
Query: 343 GGEVVLPKDQEEWKRRTGLLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVID 402
G + P E+WKR T L +YE YGQ+ETGL+CAT +K+KP +GK PPY VQ++D
Sbjct: 344 AGGPISPGVIEDWKRITKLDIYEGYGQTETGLLCATSKTIKLKPSSLGKPLPPYIVQIVD 403
Query: 403 DKGSILPPNTEGNIGIRIKPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYI 462
+ ++LPP EGNI IRIK +P SL+ + E+ A Y TGDRG MDE+GY
Sbjct: 404 ENSNLLPPGEEGNIAIRIKLNQPASLYCPHMVSWEEYASARGHMLYLTGDRGIMDEDGYF 463
Query: 463 CFLGRSDDIINASGYRI 479
+ GR DD+ NA G R+
Sbjct: 464 WWSGRVDDVANALGQRL 480
>gi|28416953 acyl-CoA synthetase short-chain family member 1 [Homo
sapiens]
Length = 689
Score = 177 bits (448), Expect = 3e-44
Identities = 154/557 (27%), Positives = 255/557 (45%), Gaps = 36/557 (6%)
Query: 48 EFNFASYVLDYWAQKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCG 107
+ N + LD +K E W + G EV+ ++RE+ + T R+AN + G
Sbjct: 107 QLNVSVNCLDQHVRKSPESVA----LIWERDEPGTEVRITYRELLETTCRLANTLKRH-G 161
Query: 108 LQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDA 167
+ +GD +A+ +P P + C R G + A+ + R+ +K K ++T +
Sbjct: 162 VHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQ 221
Query: 168 ---------LASEVDSIASQCPSLKTKLLVSDHSRE---GWLDFRSLVKSASPEHTCVKS 215
L VD CP+++ L+ + G LD + A + C
Sbjct: 222 GLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPE 281
Query: 216 K--TLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIV 273
+ D + + +TSG+TG PK H+ L + + + + D+ C++D GWI
Sbjct: 282 SMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWIT 341
Query: 274 ATIWTLVEPWTAGCT-VFIHHLPQF-DTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTS 331
+ + P G T V P + + +T+ + IN F+G + R++L+
Sbjct: 342 GHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAW 401
Query: 332 IRFPALEHCYTGGEVVLPKDQEEWK---RRTG---LLLYENYGQSETGLICA----TYWG 381
++ T G V P + E W+ R G L + + Q+ETG IC + G
Sbjct: 402 VKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEG 461
Query: 382 MKIKPGFMGKATPPYDVQVIDDKGSILP-PNTEGNIGI-RIKPVRPVSLFMCYEGDPEKT 439
+I P + ++D+KGS++ N G + I + P +++ ++ +
Sbjct: 462 AEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAY 521
Query: 440 AKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAV 499
K G +Y TGD E GY GR DD+IN SG+R+G AE+E A+ +HPAV ESAV
Sbjct: 522 FKAYPG-YYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAV 580
Query: 500 VGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKVEFVSELPKT 559
+G P I+GE AFIV+ + D D + +EL+ V + A Y P ++ V LPKT
Sbjct: 581 IGYPHDIKGEAAFAFIVVKDS--AGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKT 638
Query: 560 ITGKIERKELRKKETGQ 576
+GK+ R+ LRK T +
Sbjct: 639 RSGKVMRRLLRKIITSE 655
>gi|13375727 acyl-CoA synthetase short-chain family member 3 [Homo
sapiens]
Length = 686
Score = 167 bits (424), Expect = 2e-41
Identities = 142/541 (26%), Positives = 246/541 (45%), Gaps = 57/541 (10%)
Query: 78 NGQGDEVK-------------WSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEW 124
NG+GD++ ++++E+ + ++A V + G+++GD + + +P +P+
Sbjct: 123 NGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKH-GIKKGDTVVIYMPMIPQA 181
Query: 125 WLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCPSLKT 184
+ C R G I +K++ R+ K K +VT + E P ++
Sbjct: 182 MYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTA-SFGIEPGRRVEYVPLVEE 240
Query: 185 KLLVSDHSREGWLDFRSLVKSASP-----------------EHTCVKSKTLDPMVIFFTS 227
L + H + L + A P H CV + P+ I +TS
Sbjct: 241 ALKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTS 300
Query: 228 GTTGFPK-MAKHSHGLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAG 286
GTTG PK + + + G A+ + S + L+ +V W SD GW+V + P G
Sbjct: 301 GTTGLPKGVIRPTGGYAVMLHWSMS-SIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHG 359
Query: 287 CTVFIHH---LPQFDTKVIIQTLLKYPINHFWGVSSIYRMILQQD--------FTSIRFP 335
T ++ + D + L ++ + + + R I QQD ++ RF
Sbjct: 360 NTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFK 419
Query: 336 ALEHCYTGGEVVLPKDQEEWKRRTGLLLYENYGQSETGL-ICATYWGMKIK----PGFMG 390
L + GE + E K + + +++ Q+ETG I A+ G+ PG G
Sbjct: 420 TL---FVAGERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAG 476
Query: 391 KATPPYDVQVIDDKGSILPPNTEGNIGIRIKPVRPVSLFMCYEGDP--EKTAKVECGDFY 448
K+ P Y+V ++DD L GNI +++ P+ P + ++ + + +Y
Sbjct: 477 KSVPGYNVMILDDNMQKLKARCLGNIVVKL-PLPPGAFSGLWKNQEAFKHLYFEKFPGYY 535
Query: 449 NTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAVVGSPDPIRG 508
+T D G MDEEGY+ + R DD+IN +G+RI +E +++ H VA+ AVVG DP++G
Sbjct: 536 DTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKG 595
Query: 509 EVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKVEFVSELPKTITGKIERKE 568
V A VL ++ ++Q+ +E+ +HV+ P R FV +LPKT +GKI R
Sbjct: 596 HVPLALCVLRKD-INATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSA 654
Query: 569 L 569
L
Sbjct: 655 L 655
>gi|8923896 acyl-CoA synthetase short-chain family member 2 isoform
1 [Homo sapiens]
Length = 701
Score = 164 bits (416), Expect = 2e-40
Identities = 163/622 (26%), Positives = 263/622 (42%), Gaps = 69/622 (11%)
Query: 8 RTLWG-IHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWAQKEKEG 66
R WG I K F+ P P + + ++ N VLD + E
Sbjct: 59 REFWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLD---RNVHEK 115
Query: 67 KRGPNPAFWWV-NGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWW 125
K G AF+W N G+ + ++ ++ + +NV + G+Q+GD +A+ +P +PE
Sbjct: 116 KLGDKVAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQ-GIQKGDRVAIYMPMIPELV 174
Query: 126 LVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDA------------LASE-- 171
+ + C R G + ++ + R+ S ++T DA LA E
Sbjct: 175 VAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEAL 234
Query: 172 -------------------------VDSIASQCPSLKTKLLVSDHSREGWLD--FRSLVK 204
+ SQ P +K S +D + L++
Sbjct: 235 QKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQ 294
Query: 205 SASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSDVSW 264
A E DP+ I +TSG+TG PK H+ G + + + DV W
Sbjct: 295 EAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFW 354
Query: 265 CLSDSGWIVATIWTLVEPWTAGCT-VFIHHLPQF-DTKVIIQTLLKYPINHFWGVSSIYR 322
C +D GWI + P G T V +P + D + + KY + F+ + R
Sbjct: 355 CTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIR 414
Query: 323 MILQ---QDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTGLL---LYENYGQSETG--L 374
++++ + T +L+ T GE + P+ + R G + + + Q+ETG +
Sbjct: 415 LLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHM 474
Query: 375 ICATYWGMKIKPGFMGKATPPY---DVQVIDDKGSILPPNTEGNIGIRIKPVRPVSLFMC 431
+ +KPG AT P+ ++++ G L EG + K P +
Sbjct: 475 LTPLPGATPMKPG---SATFPFFGVAPAILNESGEELEGEAEGYLVF--KQPWPGIMRTV 529
Query: 432 YEGDP--EKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALV 489
Y E T + +Y TGD + D++GY GR DD++N SG+ + AEVESALV
Sbjct: 530 YGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALV 589
Query: 490 EHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRK 549
EH AVAE+AVVG P P++GE + F+ L K LT+EL++ ++ P P
Sbjct: 590 EHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPK--LTEELKKQIREKIGPIATPDY 647
Query: 550 VEFVSELPKTITGKIERKELRK 571
++ LPKT +GKI R+ LRK
Sbjct: 648 IQNAPGLPKTRSGKIMRRVLRK 669
>gi|253970489 acyl-CoA synthetase short-chain family member 2
isoform 2 [Homo sapiens]
Length = 714
Score = 163 bits (413), Expect = 4e-40
Identities = 169/635 (26%), Positives = 268/635 (42%), Gaps = 82/635 (12%)
Query: 8 RTLWG-IHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWAQKEKEG 66
R WG I K F+ P P + + ++ N VLD + E
Sbjct: 59 REFWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLD---RNVHEK 115
Query: 67 KRGPNPAFWWV-NGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWW 125
K G AF+W N G+ + ++ ++ + +NV + G+Q+GD +A+ +P +PE
Sbjct: 116 KLGDKVAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQ-GIQKGDRVAIYMPMIPELV 174
Query: 126 LVAVGCMRTG----IIFI-------------PATILLKAKDILYR--------------L 154
+ + C R G I+F + LL D YR L
Sbjct: 175 VAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEAL 234
Query: 155 QLSKAKGI-----VTIDALA----------SEVDSIASQCPSLKTKLLVSDHSRE---GW 196
Q + KG + + L S+ I CP ++ KL + W
Sbjct: 235 QKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQGKLKEKSKRVQPQISW 294
Query: 197 -----LDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFPGS 251
L + L++ A E DP+ I +TSG+TG PK H+ G +
Sbjct: 295 NQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTF 354
Query: 252 RKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCT-VFIHHLPQF-DTKVIIQTLLKY 309
+ + DV WC +D GWI + P G T V +P + D + + KY
Sbjct: 355 KYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKY 414
Query: 310 PINHFWGVSSIYRMILQ---QDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTGLL---L 363
+ F+ + R++++ + T +L+ T GE + P+ + R G +
Sbjct: 415 KVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPI 474
Query: 364 YENYGQSETG--LICATYWGMKIKPGFMGKATPPY---DVQVIDDKGSILPPNTEGNIGI 418
+ + Q+ETG ++ +KPG AT P+ ++++ G L EG +
Sbjct: 475 VDTFWQTETGGHMLTPLPGATPMKPG---SATFPFFGVAPAILNESGEELEGEAEGYLVF 531
Query: 419 RIKPVRPVSLFMCYEGDP--EKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASG 476
K P + Y E T + +Y TGD + D++GY GR DD++N SG
Sbjct: 532 --KQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSG 589
Query: 477 YRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQH 536
+ + AEVESALVEH AVAE+AVVG P P++GE + F+ L K LT+EL++
Sbjct: 590 HLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPK--LTEELKKQ 647
Query: 537 VKSVTAPYKYPRKVEFVSELPKTITGKIERKELRK 571
++ P P ++ LPKT +GKI R+ LRK
Sbjct: 648 IREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRK 682
>gi|156151445 acyl-CoA synthetase family member 2 [Homo sapiens]
Length = 615
Score = 117 bits (293), Expect = 3e-26
Identities = 132/533 (24%), Positives = 236/533 (44%), Gaps = 62/533 (11%)
Query: 82 DEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPA 141
++V+ +F ++ + + A+ + GL +GD L + P W L+ + + GII +
Sbjct: 96 EDVRLTFAQLKEEVDKAASGLL-SIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSV 154
Query: 142 TILLKAKDILYRLQLSKAKGIV------------TIDALASEVDSI------ASQCPSLK 183
+A ++ Y L+ K +V + + EV++ + + P L
Sbjct: 155 NPAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVENAQPGALKSQRLPDLT 214
Query: 184 TKLLVSDHSREGWLDFRSLVKSASPEHTCVKSK-------TLDPMVIFFTSGTTGFPKMA 236
T + V D G L +V + S + + DP+ I FTSGTTG PK A
Sbjct: 215 TVISV-DAPLPGTLLLDEVVAAGSTRQHLDQLQYNQQFLSCHDPINIQFTSGTTGSPKGA 273
Query: 237 KHSH----------GLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAG 286
SH G L+ +LR + + + CL G + T+ L+ G
Sbjct: 274 TLSHYNIVNNSNILGERLKLHEKTPEQLRMILPNPLYHCL---GSVAGTMMCLMY----G 326
Query: 287 CTVFIHHLPQFDTKVIIQTLLKYPINHFWGVSSIYRMILQQ-DFTSIRFPALEHCYTGGE 345
T+ + P F+ K ++ + + +G +++ IL Q DF+S + G
Sbjct: 327 ATLILAS-PIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGS 385
Query: 346 VVLPKDQEEWKRRTGLL-LYENYGQSETGLICATYWG---MKIKPGFMGKATPPYDVQVI 401
P+ + + L YG +E + ++ ++ K +G+ P + +++
Sbjct: 386 PAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIM 445
Query: 402 D-DKGSILPPNTEGNIGIRIKPVRPVSLFMCYEGDPEKTAK-VECGDFYNTGDRGKMDEE 459
+ + G++ NT G + IR + + Y G+P+KT + V+ +Y TGD M+E+
Sbjct: 446 NMEAGTLAKLNTPGELCIR-----GYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQ 500
Query: 460 GYICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTP 519
G+ +GRS D+I G I PAE+E HP V E VVG D GE + A I
Sbjct: 501 GFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACI---- 556
Query: 520 QFLSHDKDQLTKELQQHVKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKK 572
L ++ +E++ K + +K P+ + FV+ P TI+GKI++ +LR++
Sbjct: 557 -RLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 608
>gi|187761345 acyl-CoA synthetase family member 3 [Homo sapiens]
Length = 576
Score = 110 bits (276), Expect = 3e-24
Identities = 106/384 (27%), Positives = 169/384 (44%), Gaps = 48/384 (12%)
Query: 222 VIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVE 281
+I +TSGTTG PK +H ++ G + DV + + + L+
Sbjct: 198 MIIYTSGTTGRPKGVLSTHQ-NIRAVVTGLVHKWAWTKDDVILHVLPLHHVHGVVNALLC 256
Query: 282 PWTAGCTVFIHHLPQFDTKVIIQTLLKYP---INHFWGVSSIYRMILQ-----------Q 327
P G T + +P+F + + + L IN F V +IY +++ Q
Sbjct: 257 PLWVGATCVM--MPEFSPQQVWEKFLSSETPRINVFMAVPTIYTKLMEYYDRHFTQPHAQ 314
Query: 328 DFTSIRFPALEHCYTGGEVVLPKDQ-EEWKRRTGLLLYENYGQSETGLICATYWGMKIK- 385
DF G LP E+WK TG L E YG +E G+ + ++
Sbjct: 315 DFLRAVCEEKIRLMVSGSAALPLPVLEKWKNITGHTLLERYGMTEIGMALSGPLTTAVRL 374
Query: 386 PGFMGKATPPYDVQVI-----------------DDKGSILPPNTEGNIGIRIKPVRPVSL 428
PG +G P V+++ D++G+ + P E G + VR S+
Sbjct: 375 PGSVGTPLPGVQVRIVSENPQREACSYTIHAEGDERGTKVTPGFEEKEGELL--VRGPSV 432
Query: 429 FMCYEGDPEKTAKVECGD-FYNTGDRGKMDEEGYICFLGRSD-DIINASGYRIGPAEVES 486
F Y PE+T D ++ TGD + ++G GR+ DII GY++ EVE
Sbjct: 433 FREYWNKPEETKSAFTLDGWFKTGDT-VVFKDGQYWIRGRTSVDIIKTGGYKVSALEVEW 491
Query: 487 ALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTP-QFLSHDKDQLTKELQQHVKSVTAPYK 545
L+ HP++ + AV+G PD G+ V A + L LSH +EL++ ++V APY
Sbjct: 492 HLLAHPSITDVAVIGVPDMTWGQRVTAVVTLREGHSLSH------RELKEWARNVLAPYA 545
Query: 546 YPRKVEFVSELPKTITGKIERKEL 569
P ++ V E+P+ GKI++K L
Sbjct: 546 VPSELVLVEEIPRNQMGKIDKKAL 569
>gi|187761343 acyl-CoA synthetase family member 3 [Homo sapiens]
Length = 576
Score = 110 bits (276), Expect = 3e-24
Identities = 106/384 (27%), Positives = 169/384 (44%), Gaps = 48/384 (12%)
Query: 222 VIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVE 281
+I +TSGTTG PK +H ++ G + DV + + + L+
Sbjct: 198 MIIYTSGTTGRPKGVLSTHQ-NIRAVVTGLVHKWAWTKDDVILHVLPLHHVHGVVNALLC 256
Query: 282 PWTAGCTVFIHHLPQFDTKVIIQTLLKYP---INHFWGVSSIYRMILQ-----------Q 327
P G T + +P+F + + + L IN F V +IY +++ Q
Sbjct: 257 PLWVGATCVM--MPEFSPQQVWEKFLSSETPRINVFMAVPTIYTKLMEYYDRHFTQPHAQ 314
Query: 328 DFTSIRFPALEHCYTGGEVVLPKDQ-EEWKRRTGLLLYENYGQSETGLICATYWGMKIK- 385
DF G LP E+WK TG L E YG +E G+ + ++
Sbjct: 315 DFLRAVCEEKIRLMVSGSAALPLPVLEKWKNITGHTLLERYGMTEIGMALSGPLTTAVRL 374
Query: 386 PGFMGKATPPYDVQVI-----------------DDKGSILPPNTEGNIGIRIKPVRPVSL 428
PG +G P V+++ D++G+ + P E G + VR S+
Sbjct: 375 PGSVGTPLPGVQVRIVSENPQREACSYTIHAEGDERGTKVTPGFEEKEGELL--VRGPSV 432
Query: 429 FMCYEGDPEKTAKVECGD-FYNTGDRGKMDEEGYICFLGRSD-DIINASGYRIGPAEVES 486
F Y PE+T D ++ TGD + ++G GR+ DII GY++ EVE
Sbjct: 433 FREYWNKPEETKSAFTLDGWFKTGDT-VVFKDGQYWIRGRTSVDIIKTGGYKVSALEVEW 491
Query: 487 ALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTP-QFLSHDKDQLTKELQQHVKSVTAPYK 545
L+ HP++ + AV+G PD G+ V A + L LSH +EL++ ++V APY
Sbjct: 492 HLLAHPSITDVAVIGVPDMTWGQRVTAVVTLREGHSLSH------RELKEWARNVLAPYA 545
Query: 546 YPRKVEFVSELPKTITGKIERKEL 569
P ++ V E+P+ GKI++K L
Sbjct: 546 VPSELVLVEEIPRNQMGKIDKKAL 569
>gi|38524616 solute carrier family 27, member 1 [Homo sapiens]
Length = 646
Score = 88.2 bits (217), Expect = 2e-17
Identities = 127/521 (24%), Positives = 210/521 (40%), Gaps = 51/521 (9%)
Query: 86 WSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPATILL 145
W+F ++ + VAN+F Q G GD +A+ L PE+ + +G + G+ + L
Sbjct: 104 WTFAQLDAYSNAVANLFRQL-GFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNL 162
Query: 146 KAKDILYRLQLSKAKGIVTIDALASEVDSIASQCPSLKTKLLVSDHSREGWLD----FRS 201
+ + + + L S AK ++ + + V ++ K D EG L
Sbjct: 163 RREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDP 222
Query: 202 LVKSASPEHTC-VKSKTLDPMVIF-FTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKT 259
L+K AS + SK +D + + +TSGTTG PK A H + + G R ++
Sbjct: 223 LLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYR-MQA 281
Query: 260 SDVSW-CLS---DSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTKVIIQTLLKYPINHFW 315
+DV + CL +G I+ L+ G TV + +F +KY
Sbjct: 282 ADVLYDCLPLYHSAGNIIGVGQCLIY----GLTVVLRK--KFSASRFWDDCIKYNCTVVQ 335
Query: 316 GVSSIYRMILQQDFTSIRFPALEHCY--TGGEVVLPKDQEEWKRRTGLL-LYENYGQSET 372
+ I R +L+Q +R H G + P EE+ R G+ + E YG +E
Sbjct: 336 YIGEICRYLLKQP---VREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATEC 392
Query: 373 GLICATYWGMKIKPGFMGKATPPY-----------DVQVIDDKGSILPPNTEGNIGIRIK 421
A G GF + P ++++ D + P G G+ +
Sbjct: 393 NCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVG 452
Query: 422 PVR---PVSLFMCYEGDPEKTAKVECGDF------YNTGDRGKMDEEGYICFLGRSDDII 472
+ P+ F Y + + K+ F Y +GD MDE GY+ F RS D
Sbjct: 453 QINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTF 512
Query: 473 NASGYRIGPAEVESALVEHPAVAESAVVGSPDP-IRGEVVKAFIVLTPQFLSHDKDQLTK 531
G + EVE L + AV G P + G+ A + L D + + +
Sbjct: 513 RWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLL--DPNAIYQ 570
Query: 532 ELQQHVKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKK 572
ELQ+ V APY P + + ++ T T KI++ L+++
Sbjct: 571 ELQK----VLAPYARPIFLRLLPQVDTTGTFKIQKTRLQRE 607
>gi|13236579 solute carrier family 27 member 3 [Homo sapiens]
Length = 730
Score = 81.3 bits (199), Expect = 2e-15
Identities = 126/498 (25%), Positives = 195/498 (39%), Gaps = 62/498 (12%)
Query: 108 LQQGDHLALMLPRVPEWWLVAVGCMRTGI--IFIPATILLKAKDILYRLQLSKAKGIVTI 165
L G +AL+LP PE+ + G + G+ F+P L+ +L+ L+ A+ +V
Sbjct: 211 LSPGATVALLLPAGPEFLWLWFGLAKAGLRTAFVPTA--LRRGPLLHCLRSCGARALV-- 266
Query: 166 DALASE-VDSIASQCPSLKTKLL-------------VSDHSREGWLDFRSLVKSASPEHT 211
LA E ++S+ P+L+ L +SD E + V P +
Sbjct: 267 --LAPEFLESLEPDLPALRAMGLHLWAAGPGTHPAGISDLLAE----VSAEVDGPVPGYL 320
Query: 212 CVKSKTLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSDVSWCLSDSGW 271
D + FTSGTTG PK A+ SH LQ G +L + DV +
Sbjct: 321 SSPQSITDTCLYIFTSGTTGLPKAARISHLKILQ--CQGFYQLCGVHQEDVIYLALPLYH 378
Query: 272 IVATIWTLVEPWTAGCTVFIHHLPQFDTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTS 331
+ ++ +V G TV + +F + ++ + F + + R ++ Q +
Sbjct: 379 MSGSLLGIVGCMGIGATVVLK--SKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPSK 436
Query: 332 IRFPALEHCYTGGEVVLPKDQEEWKRRTG-LLLYENYGQSETGLICATYWGMKIKPGFMG 390
G + P E + RR G L + E YG +E + Y G + G +G
Sbjct: 437 AERGHKVRLAVGSG-LRPDTWERFVRRFGPLQVLETYGLTEGNVATINYTGQR---GAVG 492
Query: 391 KAT-----------PPYDV---QVIDDKGSILPPNTEGNIGIRIKPVRPVSLFMCYEGDP 436
+A+ YDV + I D + G G+ + PV S F+ Y G P
Sbjct: 493 RASWLYKHIFPFSLIRYDVTTGEPIRDPQGHCMATSPGEPGLLVAPVSQQSPFLGYAGGP 552
Query: 437 E----KTAK--VECGD-FYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALV 489
E K K GD F+NTGD D++G++ F R+ D G + EV
Sbjct: 553 ELAQGKLLKDVFRPGDVFFNTGDLLVCDDQGFLRFHDRTGDTFRWKGENVATTEVAEVFE 612
Query: 490 EHPAVAESAVVGSPDP-IRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPR 548
+ E V G P G A +VL P H D + +L HV PY PR
Sbjct: 613 ALDFLQEVNVYGVTVPGHEGRAGMAALVLRP---PHALDLM--QLYTHVSENLPPYARPR 667
Query: 549 KVEFVSELPKTITGKIER 566
+ L T T K ++
Sbjct: 668 FLRLQESLATTETFKQQK 685
>gi|227499619 solute carrier family 27 (fatty acid transporter),
member 2 isoform 1 [Homo sapiens]
Length = 620
Score = 72.0 bits (175), Expect = 1e-12
Identities = 120/535 (22%), Positives = 203/535 (37%), Gaps = 78/535 (14%)
Query: 87 SFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPATILLK 146
++ ++ + +VA GL+QGD +AL++ P + + +G ++ G ++
Sbjct: 80 TYAQVDRRSNQVARALHDHLGLRQGDCVALLMGNEPAYVWLWLGLVKLGCAMACLNYNIR 139
Query: 147 AKDILYRLQLSKAKGIVTIDALASEVDSIASQCPSLK----TKLLVSDHSREGWLD-FRS 201
AK +L+ Q AK ++ L + V+ I PSLK + VS S +D F
Sbjct: 140 AKSLLHCFQCCGAKVLLVSPELQAAVEEI---LPSLKKDDVSIYYVSRTSNTDGIDSFLD 196
Query: 202 LVKSAS----PEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSL 257
V S PE + P + +TSGTTG PK A +H + G + L
Sbjct: 197 KVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAMITHQRIWYGT--GLTFVSGL 254
Query: 258 KTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTKVIIQTLLKYPINHFWGV 317
K DV + TL +A + IH + ++T K+ + FW
Sbjct: 255 KADDVIYI------------TLPFYHSAALLIGIHGCIVAGATLALRT--KFSASQFWDD 300
Query: 318 SSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEE--------------W----KRRT 359
Y + T I++ Y P D++ W KR
Sbjct: 301 CRKYNV------TVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRGDVWRQFVKRFG 354
Query: 360 GLLLYENYGQSETGLICATY---WGMKIKPGFMGKATPPYDV--------QVIDDKGSIL 408
+ +YE Y +E + Y G + ++ K YD+ + + D+
Sbjct: 355 DICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYC 414
Query: 409 PPNTEGNIGIRIKPVRPVSLFMCYEGDPEKTAKVECGD-------FYNTGDRGKMDEEGY 461
+G +G+ + + ++ F Y G +T K + D ++N+GD +D E +
Sbjct: 415 VRVPKGEVGLLVCKITQLTPFNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENF 474
Query: 462 ICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAVVGSPDP-IRGEVVKAFIVLTPQ 520
I F R D G + EV + V E V G P G + A I +
Sbjct: 475 IYFHDRVGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGRIGMASIKMKE- 533
Query: 521 FLSHDKDQLTKELQQHVKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKKETG 575
+H+ D K+L QH+ Y PR + + ITG + +++ E G
Sbjct: 534 --NHEFD--GKKLFQHIADYLPSYARPRFLRIQDTI--EITGTFKHRKMTLVEEG 582
>gi|40807357 solute carrier family 27 (fatty acid transporter),
member 4 [Homo sapiens]
Length = 643
Score = 70.9 bits (172), Expect = 3e-12
Identities = 130/528 (24%), Positives = 198/528 (37%), Gaps = 54/528 (10%)
Query: 80 QGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWWLVAVGCMRTGIIFI 139
+G + W+FR++ + + VAN F Q GL GD A+ + E+ + +G + G+
Sbjct: 96 EGTDTHWTFRQLDEYSSSVAN-FLQARGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAA 154
Query: 140 PATILLKAKDILYRLQLSKAKGIVTIDALASEVDSI-ASQCPSLKTKLLVSDHSREGWLD 198
L+ +L+ L S+A+ +V +AS + + AS PSL L S G +
Sbjct: 155 LINTNLRRDALLHCLTTSRARALVFGSEMASAICEVHASLDPSLS--LFCSGSWEPGAVP 212
Query: 199 -----FRSLVKSASPEH--TCVKSKTLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFPGS 251
L+K A P+H +C D + +TSGTTG PK A H + +
Sbjct: 213 PSTEHLDPLLKDA-PKHLPSCPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVY 271
Query: 252 RKLRSLKTSDVSWCL---SDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTKVIIQTLLK 308
R V CL +G IV L+ G TV I +F +K
Sbjct: 272 YGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLH----GMTVVIR--KKFSASRFWDDCIK 325
Query: 309 YPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTGLL----LY 364
Y + + R +L Q G + Q W + +
Sbjct: 326 YNCTIVQYIGELCRYLLNQPPREAENQHQVRMALGNGL----RQSIWTNFSSRFHIPQVA 381
Query: 365 ENYGQSETGLICATYWGMKIKPGFMGK----ATPPYDVQVIDD--------KGSILP--P 410
E YG +E + GF + P V+V +D G +P P
Sbjct: 382 EFYGATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQP 441
Query: 411 NTEGNIGIRIKPVRPVSLFMCYEGDPEKTAKVECGDF------YNTGDRGKMDEEGYICF 464
G + RI P+ F Y K+ F Y TGD MDE GY+ F
Sbjct: 442 GEPGQLVGRIIQKDPLRRFDGYLNQGANNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYF 501
Query: 465 LGRSDDIINASGYRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSH 524
R+ D G + EVE L +A+ AV G P V +P +
Sbjct: 502 RDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVASPTG-NC 560
Query: 525 DKDQLTKELQQHVKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKK 572
D ++ + L++ + Y P + + EL KT T K ++ ELRK+
Sbjct: 561 DLERFAQVLEKELPL----YARPIFLRLLPELHKTGTYKFQKTELRKE 604
>gi|209529739 hypothetical protein LOC100132247 [Homo sapiens]
Length = 1133
Score = 64.7 bits (156), Expect = 2e-10
Identities = 32/41 (78%), Positives = 35/41 (85%)
Query: 510 VVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKV 550
+VK IVLTPQFLSHD+ QLTKELQQHVKSVT P +Y RKV
Sbjct: 1 MVKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRKV 41
>gi|239745501 PREDICTED: similar to acyl-CoA synthetase medium-chain
family member 2 [Homo sapiens]
Length = 1122
Score = 64.7 bits (156), Expect = 2e-10
Identities = 32/41 (78%), Positives = 35/41 (85%)
Query: 510 VVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKV 550
+VK IVLTPQFLSHD+ QLTKELQQHVKSVT P +Y RKV
Sbjct: 1 MVKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRKV 41
>gi|157074225 nuclear pore complex interacting protein-like 3 [Homo
sapiens]
Length = 678
Score = 64.7 bits (156), Expect = 2e-10
Identities = 32/41 (78%), Positives = 35/41 (85%)
Query: 510 VVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKV 550
+VK IVLTPQFLSHD+ QLTKELQQHVKSVT P +Y RKV
Sbjct: 1 MVKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRKV 41
>gi|239745482 PREDICTED: hypothetical protein [Homo sapiens]
Length = 449
Score = 64.3 bits (155), Expect = 3e-10
Identities = 31/42 (73%), Positives = 35/42 (83%)
Query: 509 EVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKV 550
++VK IVLTPQFLSHD+ Q TKELQQHVKSVT P +Y RKV
Sbjct: 17 QMVKLSIVLTPQFLSHDQSQFTKELQQHVKSVTCPCEYLRKV 58
>gi|239745430 PREDICTED: hypothetical protein XP_002343465 [Homo
sapiens]
Length = 317
Score = 63.2 bits (152), Expect = 6e-10
Identities = 31/41 (75%), Positives = 35/41 (85%)
Query: 510 VVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKV 550
+VK IVLTP+FLSHD+ QLTKELQQHVKSVT P +Y RKV
Sbjct: 1 MVKLSIVLTPRFLSHDQGQLTKELQQHVKSVTCPCEYLRKV 41
>gi|239745418 PREDICTED: similar to GPS, PLAT and transmembrane
domain-containing protein FLJ00285 [Homo sapiens]
Length = 317
Score = 63.2 bits (152), Expect = 6e-10
Identities = 31/41 (75%), Positives = 35/41 (85%)
Query: 510 VVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKV 550
+VK IVLTP+FLSHD+ QLTKELQQHVKSVT P +Y RKV
Sbjct: 1 MVKLSIVLTPRFLSHDQGQLTKELQQHVKSVTCPCEYLRKV 41
>gi|239745416 PREDICTED: similar to GPS, PLAT and transmembrane
domain-containing protein FLJ00285 [Homo sapiens]
Length = 317
Score = 63.2 bits (152), Expect = 6e-10
Identities = 31/41 (75%), Positives = 35/41 (85%)
Query: 510 VVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKV 550
+VK IVLTP+FLSHD+ QLTKELQQHVKSVT P +Y RKV
Sbjct: 1 MVKLSIVLTPRFLSHDQGQLTKELQQHVKSVTCPCEYLRKV 41
>gi|13325057 solute carrier family 27 (fatty acid transporter),
member 5 [Homo sapiens]
Length = 690
Score = 62.4 bits (150), Expect = 1e-09
Identities = 92/380 (24%), Positives = 151/380 (39%), Gaps = 50/380 (13%)
Query: 220 PMVIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTL 279
P + +TSGTTG PK A +H LQ S S L DV + + ++ + +
Sbjct: 289 PALFIYTSGTTGLPKPAILTHERVLQMSKMLS--LSGATADDVVYTVLPLYHVMGLVVGI 346
Query: 280 VEPWTAGCTVFIHHLPQFDTKVIIQTLLKYPINHFWGVSSIYRMILQ-----QDFTSIRF 334
+ G T + P+F T ++ + V + R + +D T
Sbjct: 347 LGCLDLGATCVL--APKFSTSCFWDDCRQHGVTVILYVGELLRYLCNIPQQPEDRTHTVR 404
Query: 335 PALEHCYTGGEVVLPKDQEEWKRRTG-LLLYENYGQSETGLICATYWGMKIKPGFMGKAT 393
A+ G + E +++R G + ++E YG +E + Y G + G +GK +
Sbjct: 405 LAM------GNGLRADVWETFQQRFGPIRIWEVYGSTEGNMGLVNYVG---RCGALGKMS 455
Query: 394 ------PPYDV---------QVIDDKGSILPPNTEGNIGIRIKPVRPVSLFMCYEGDPEK 438
P+++ V D++G +P G G+ + V F+ Y G E
Sbjct: 456 CLLRMLSPFELVQFDMEAAEPVRDNQGFCIPVGL-GEPGLLLTKVVSQQPFVGYRGPREL 514
Query: 439 TAKV------ECGD-FYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALVEH 491
+ + + GD +YNTGD MD EG++ F R D G + EVE L +
Sbjct: 515 SERKLVRNVRQSGDVYYNTGDVLAMDREGFLYFRDRLGDTFRWKGENVSTHEVEGVLSQV 574
Query: 492 PAVAESAVVGSPDP-IRGEVVKAFIVLTP-QFLSHDKDQLTKELQQHVKSVTAPYKYPRK 549
+ + V G P G+V A + L P Q +K L QHV++ Y P
Sbjct: 575 DFLQQVNVYGVCVPGCEGKVGMAAVQLAPGQTFDGEK------LYQHVRAWLPAYATPHF 628
Query: 550 VEFVSELPKTITGKIERKEL 569
+ + T T K+ + L
Sbjct: 629 IRIQDAMEVTSTFKLMKTRL 648
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.435
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,743,098
Number of Sequences: 37866
Number of extensions: 1109367
Number of successful extensions: 2349
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 2239
Number of HSP's gapped (non-prelim): 69
length of query: 577
length of database: 18,247,518
effective HSP length: 108
effective length of query: 469
effective length of database: 14,157,990
effective search space: 6640097310
effective search space used: 6640097310
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.