Guide to the Human Genome
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Search of human proteins with 224586853

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
         (1004 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ...  2081   0.0  
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s...  2056   0.0  
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ...   555   e-158
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ...   555   e-157
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ...   555   e-157
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ...   555   e-157
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ...   555   e-157
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ...   555   e-157
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa...   297   4e-80
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s...   297   4e-80
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s...   291   2e-78
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s...   291   2e-78
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s...   283   7e-76
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ...   230   4e-60
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s...   228   2e-59
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s...   201   4e-51
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s...   199   1e-50
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]        101   3e-21
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]        101   3e-21
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]        101   3e-21
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]         93   1e-18
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]        91   5e-18
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H...    88   5e-17
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]                87   1e-16
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                87   1e-16
gi|11321634 CD2-associated protein [Homo sapiens]                      83   1e-15
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ...    83   1e-15
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]        82   2e-15
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    81   4e-15
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    81   4e-15

>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
            sapiens]
          Length = 1004

 Score = 2081 bits (5392), Expect = 0.0
 Identities = 1004/1004 (100%), Positives = 1004/1004 (100%)

Query: 1    MKATTPLQTVDRPKDWYKTMFKQIHMVHKPGLYNPPYSAQSHPAAKTQTYRPLSKSHSDN 60
            MKATTPLQTVDRPKDWYKTMFKQIHMVHKPGLYNPPYSAQSHPAAKTQTYRPLSKSHSDN
Sbjct: 1    MKATTPLQTVDRPKDWYKTMFKQIHMVHKPGLYNPPYSAQSHPAAKTQTYRPLSKSHSDN 60

Query: 61   SPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYE 120
            SPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYE
Sbjct: 61   SPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYE 120

Query: 121  PGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASR 180
            PGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASR
Sbjct: 121  PGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASR 180

Query: 181  TSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCS 240
            TSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCS
Sbjct: 181  TSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCS 240

Query: 241  TYRQHLDVPRDSPRAISFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFP 300
            TYRQHLDVPRDSPRAISFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFP
Sbjct: 241  TYRQHLDVPRDSPRAISFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFP 300

Query: 301  DPKVKSESMGSLLCEEDSKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKM 360
            DPKVKSESMGSLLCEEDSKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKM
Sbjct: 301  DPKVKSESMGSLLCEEDSKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKM 360

Query: 361  HRINRKDLMNSEVICSVKSRILQYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKL 420
            HRINRKDLMNSEVICSVKSRILQYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKL
Sbjct: 361  HRINRKDLMNSEVICSVKSRILQYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKL 420

Query: 421  IQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNAL 480
            IQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNAL
Sbjct: 421  IQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNAL 480

Query: 481  VPIHIEVTSDEQPRAHVEFSDSDQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFY 540
            VPIHIEVTSDEQPRAHVEFSDSDQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFY
Sbjct: 481  VPIHIEVTSDEQPRAHVEFSDSDQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFY 540

Query: 541  GSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSK 600
            GSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSK
Sbjct: 541  GSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSK 600

Query: 601  LAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSI 660
            LAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSI
Sbjct: 601  LAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSI 660

Query: 661  LHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQD 720
            LHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQD
Sbjct: 661  LHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQD 720

Query: 721  VDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKA 780
            VDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKA
Sbjct: 721  VDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKA 780

Query: 781  QTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQ 840
            QTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQ
Sbjct: 781  QTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQ 840

Query: 841  PGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 900
            PGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV
Sbjct: 841  PGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 900

Query: 901  VKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 960
            VKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN
Sbjct: 901  VKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 960

Query: 961  EDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            EDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 961  EDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004


>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
            sapiens]
          Length = 1100

 Score = 2056 bits (5326), Expect = 0.0
 Identities = 996/1011 (98%), Positives = 996/1011 (98%), Gaps = 15/1011 (1%)

Query: 9    TVDRPKDWYKTMFKQIHMVHKP---------------GLYNPPYSAQSHPAAKTQTYRPL 53
            TVDRPKDWYKTMFKQIHMVHKP               GLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 90   TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 149

Query: 54   SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 113
            SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 150  SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 209

Query: 114  RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL 173
            RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL
Sbjct: 210  RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL 269

Query: 174  GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLNGNPS 233
            GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLNGNPS
Sbjct: 270  GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLNGNPS 329

Query: 234  SELDYCSTYRQHLDVPRDSPRAISFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLN 293
            SELDYCSTYRQHLDVPRDSPRAISFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLN
Sbjct: 330  SELDYCSTYRQHLDVPRDSPRAISFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLN 389

Query: 294  DDCDSFPDPKVKSESMGSLLCEEDSKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGF 353
            DDCDSFPDPKVKSESMGSLLCEEDSKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGF
Sbjct: 390  DDCDSFPDPKVKSESMGSLLCEEDSKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGF 449

Query: 354  LKMYKKMHRINRKDLMNSEVICSVKSRILQYESEQQHKDLLRAWSQCSTEEVPRDMVPTR 413
            LKMYKKMHRINRKDLMNSEVICSVKSRILQYESEQQHKDLLRAWSQCSTEEVPRDMVPTR
Sbjct: 450  LKMYKKMHRINRKDLMNSEVICSVKSRILQYESEQQHKDLLRAWSQCSTEEVPRDMVPTR 509

Query: 414  ISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRR 473
            ISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRR
Sbjct: 510  ISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRR 569

Query: 474  GCQSNALVPIHIEVTSDEQPRAHVEFSDSDQDGVVSDHSDYIHLEGSSFCSESDFDHFSF 533
            GCQSNALVPIHIEVTSDEQPRAHVEFSDSDQDGVVSDHSDYIHLEGSSFCSESDFDHFSF
Sbjct: 570  GCQSNALVPIHIEVTSDEQPRAHVEFSDSDQDGVVSDHSDYIHLEGSSFCSESDFDHFSF 629

Query: 534  TSSESFYGSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQE 593
            TSSESFYGSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQE
Sbjct: 630  TSSESFYGSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQE 689

Query: 594  MDPGLSKLAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRG 653
            MDPGLSKLAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRG
Sbjct: 690  MDPGLSKLAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRG 749

Query: 654  SLPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRMP 713
            SLPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRMP
Sbjct: 750  SLPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRMP 809

Query: 714  RSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK 773
            RSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK
Sbjct: 810  RSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK 869

Query: 774  AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 833
            AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA
Sbjct: 870  AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 929

Query: 834  RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIF 893
            RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIF
Sbjct: 930  RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIF 989

Query: 894  PVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQAL 953
            PVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQAL
Sbjct: 990  PVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQAL 1049

Query: 954  YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 1050 YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100


>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
            sapiens]
          Length = 661

 Score =  555 bits (1431), Expect = e-158
 Identities = 295/398 (74%), Positives = 315/398 (79%), Gaps = 13/398 (3%)

Query: 612  RKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPD 671
            RK  S P+   E    K+S+ +      K   D ++ +   G   + S+    I   L +
Sbjct: 272  RKFRSEPRSIFEYEPGKSSILQHERPPPKKPLDYVQ-DHSSGVFNEASLYQSSIDRSL-E 329

Query: 672  VPERNSSL----RALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANS 726
             P  ++S+    R  R+S P   P   L    A    P + D   +P S++       +S
Sbjct: 330  RPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSS 386

Query: 727  SCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 786
            S     R    +DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL
Sbjct: 387  SPSSPSRA---KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 443

Query: 787  SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 846
            SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE
Sbjct: 444  SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 503

Query: 847  AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 906
            AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK
Sbjct: 504  AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 563

Query: 907  GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 966
            GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL
Sbjct: 564  GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 623

Query: 967  RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 624  RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661



 Score =  402 bits (1032), Expect = e-111
 Identities = 215/294 (73%), Positives = 223/294 (75%), Gaps = 45/294 (15%)

Query: 9   TVDRPKDWYKTMFKQIHMVHKP---------------GLYNPPYSAQSHPAAKTQTYRPL 53
           TVDRPKDWYKTMFKQIHMVHKP               GLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 159 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 218

Query: 54  SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 113
           SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 219 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 278

Query: 114 RSIFEYEPGKSSILQHERP-------------------ASLYQSSIDRSLERPMSSASMA 154
           RSIFEYEPGKSSILQHERP                   ASLYQSSIDRSLERPMSSASMA
Sbjct: 279 RSIFEYEPGKSSILQHERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMA 338

Query: 155 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGD 214
           SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK  +
Sbjct: 339 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRE 398

Query: 215 DSKICPSLCSYSGLN------GNPSSE-LDYCSTYRQHLDVPRDSPRAISFKNG 261
             +   S  +  G +      G P  E L   + Y    D    + + +SFK G
Sbjct: 399 SPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVY----DFKAQTSKELSFKKG 448


>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
            sapiens]
          Length = 492

 Score =  555 bits (1429), Expect = e-157
 Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)

Query: 677  SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 735
            S  R  R+S P   P   L    A    P + D   +P S++       +SS     R  
Sbjct: 170  SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 225

Query: 736  ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 795
              +DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 226  --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 283

Query: 796  ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 855
            ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 284  ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 343

Query: 856  DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 915
            DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 344  DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 403

Query: 916  IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 975
            IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 404  IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 463

Query: 976  EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 464  EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492



 Score =  429 bits (1102), Expect = e-120
 Identities = 223/283 (78%), Positives = 231/283 (81%), Gaps = 26/283 (9%)

Query: 1   MKATTPLQTVDRPKDWYKTMFKQIHMVHKP---------------GLYNPPYSAQSHPAA 45
           MKATTPLQTVDRPKDWYKTMFKQIHMVHKP               GLYNPPYSAQSHPAA
Sbjct: 1   MKATTPLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAA 60

Query: 46  KTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVD 105
           KTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVD
Sbjct: 61  KTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVD 120

Query: 106 TRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEP 165
           TRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEP
Sbjct: 121 TRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEP 180

Query: 166 AVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSY 225
           AVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK  +  +   S  + 
Sbjct: 181 AVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTD 240

Query: 226 SGLN------GNPSSE-LDYCSTYRQHLDVPRDSPRAISFKNG 261
            G +      G P  E L   + Y    D    + + +SFK G
Sbjct: 241 MGRSAPRERRGTPEKEKLPAKAVY----DFKAQTSKELSFKKG 279


>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
            sapiens]
          Length = 824

 Score =  555 bits (1429), Expect = e-157
 Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)

Query: 677  SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 735
            S  R  R+S P   P   L    A    P + D   +P S++       +SS     R  
Sbjct: 502  SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 557

Query: 736  ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 795
              +DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 558  --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 615

Query: 796  ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 855
            ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 616  ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 675

Query: 856  DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 915
            DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 676  DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 735

Query: 916  IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 975
            IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 736  IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 795

Query: 976  EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 796  EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824



 Score =  282 bits (721), Expect = 1e-75
 Identities = 183/347 (52%), Positives = 196/347 (56%), Gaps = 98/347 (28%)

Query: 9   TVDRPKDWYKTMFKQIHMVHKP---------------GLYNPPYSAQSHPAAKTQTYRPL 53
           TVDRPKDWYKTMFKQIHMVHKP               GLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 269 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 328

Query: 54  SKSHSDNSPNAFKDASSPVPPPHVPPPV-----------------PPLRPRD-------- 88
           SKSHSDNSPNAFKDASSPVPPPHVPPPV                 PP R  D        
Sbjct: 329 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 388

Query: 89  ---------RSSTEKHDWDPPDRKVDT-------RKFRSE-------------PRSIFEY 119
                    +SS  +H+  PP     T       RK  S              PRS    
Sbjct: 389 RSIFEYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPT 448

Query: 120 EPGKSSILQHERP------------------ASLYQSSIDRSLERPMSSASMASDFRKRR 161
              ++  L   RP                  ASLYQSSIDRSLERPMSSASMASDFRKRR
Sbjct: 449 PSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR 508

Query: 162 KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPS 221
           KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK  +  +   S
Sbjct: 509 KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSS 568

Query: 222 LCSYSGLN------GNPSSE-LDYCSTYRQHLDVPRDSPRAISFKNG 261
             +  G +      G P  E L   + Y    D    + + +SFK G
Sbjct: 569 TLTDMGRSAPRERRGTPEKEKLPAKAVY----DFKAQTSKELSFKKG 611


>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
            sapiens]
          Length = 731

 Score =  555 bits (1429), Expect = e-157
 Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)

Query: 677  SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 735
            S  R  R+S P   P   L    A    P + D   +P S++       +SS     R  
Sbjct: 409  SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 464

Query: 736  ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 795
              +DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 465  --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 522

Query: 796  ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 855
            ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 523  ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 582

Query: 856  DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 915
            DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 583  DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 642

Query: 916  IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 975
            IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 643  IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 702

Query: 976  EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 703  EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731



 Score =  282 bits (721), Expect = 1e-75
 Identities = 183/347 (52%), Positives = 196/347 (56%), Gaps = 98/347 (28%)

Query: 9   TVDRPKDWYKTMFKQIHMVHKP---------------GLYNPPYSAQSHPAAKTQTYRPL 53
           TVDRPKDWYKTMFKQIHMVHKP               GLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 176 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 235

Query: 54  SKSHSDNSPNAFKDASSPVPPPHVPPPV-----------------PPLRPRD-------- 88
           SKSHSDNSPNAFKDASSPVPPPHVPPPV                 PP R  D        
Sbjct: 236 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 295

Query: 89  ---------RSSTEKHDWDPPDRKVDT-------RKFRSE-------------PRSIFEY 119
                    +SS  +H+  PP     T       RK  S              PRS    
Sbjct: 296 RSIFEYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPT 355

Query: 120 EPGKSSILQHERP------------------ASLYQSSIDRSLERPMSSASMASDFRKRR 161
              ++  L   RP                  ASLYQSSIDRSLERPMSSASMASDFRKRR
Sbjct: 356 PSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR 415

Query: 162 KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPS 221
           KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK  +  +   S
Sbjct: 416 KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSS 475

Query: 222 LCSYSGLN------GNPSSE-LDYCSTYRQHLDVPRDSPRAISFKNG 261
             +  G +      G P  E L   + Y    D    + + +SFK G
Sbjct: 476 TLTDMGRSAPRERRGTPEKEKLPAKAVY----DFKAQTSKELSFKKG 518


>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
            sapiens]
          Length = 644

 Score =  555 bits (1429), Expect = e-157
 Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)

Query: 677  SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 735
            S  R  R+S P   P   L    A    P + D   +P S++       +SS     R  
Sbjct: 322  SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 377

Query: 736  ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 795
              +DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 378  --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 435

Query: 796  ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 855
            ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 436  ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 495

Query: 856  DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 915
            DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 496  DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 555

Query: 916  IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 975
            IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 556  IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 615

Query: 976  EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 616  EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644



 Score =  423 bits (1088), Expect = e-118
 Identities = 215/260 (82%), Positives = 223/260 (85%), Gaps = 11/260 (4%)

Query: 9   TVDRPKDWYKTMFKQIHMVHKPGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDA 68
           TVDRPKDWYKTMFKQIHMVHKPGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDA
Sbjct: 176 TVDRPKDWYKTMFKQIHMVHKPGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDA 235

Query: 69  SSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQ 128
           SSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQ
Sbjct: 236 SSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQ 295

Query: 129 HERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDL 188
           HERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDL
Sbjct: 296 HERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDL 355

Query: 189 PGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLN------GNPSSE-LDYCST 241
           PGSSTTLTKSFTSSSPSSPSRAK  +  +   S  +  G +      G P  E L   + 
Sbjct: 356 PGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAV 415

Query: 242 YRQHLDVPRDSPRAISFKNG 261
           Y    D    + + +SFK G
Sbjct: 416 Y----DFKAQTSKELSFKKG 431


>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
            sapiens]
          Length = 666

 Score =  555 bits (1429), Expect = e-157
 Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)

Query: 677  SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 735
            S  R  R+S P   P   L    A    P + D   +P S++       +SS     R  
Sbjct: 344  SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 399

Query: 736  ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 795
              +DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 400  --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 457

Query: 796  ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 855
            ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 458  ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 517

Query: 856  DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 915
            DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 518  DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 577

Query: 916  IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 975
            IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 578  IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 637

Query: 976  EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 638  EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666



 Score =  391 bits (1004), Expect = e-108
 Identities = 215/322 (66%), Positives = 223/322 (69%), Gaps = 73/322 (22%)

Query: 9   TVDRPKDWYKTMFKQIHMVHKP---------------GLYNPPYSAQSHPAAKTQTYRPL 53
           TVDRPKDWYKTMFKQIHMVHKP               GLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 136 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 195

Query: 54  SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 113
           SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 196 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 255

Query: 114 RSIFEYEPGKSSILQHERP----------------------------------------- 132
           RSIFEYEPGKSSILQHERP                                         
Sbjct: 256 RSIFEYEPGKSSILQHERPTDRINPDDIDLENEPWYKFFSELEFGRPPPKKPLDYVQDHS 315

Query: 133 ------ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV 186
                 ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV
Sbjct: 316 SGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV 375

Query: 187 DLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLN------GNPSSE-LDYC 239
           DLPGSSTTLTKSFTSSSPSSPSRAK  +  +   S  +  G +      G P  E L   
Sbjct: 376 DLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK 435

Query: 240 STYRQHLDVPRDSPRAISFKNG 261
           + Y    D    + + +SFK G
Sbjct: 436 AVY----DFKAQTSKELSFKKG 453


>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
            sapiens]
          Length = 816

 Score =  297 bits (760), Expect = 4e-80
 Identities = 156/271 (57%), Positives = 191/271 (70%), Gaps = 7/271 (2%)

Query: 738  QDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYI 796
            +D ESPR +     D   S     RR   +KE  PA+A +DFKAQT KEL  +KGD VYI
Sbjct: 547  KDSESPRHFIPA--DYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYI 604

Query: 797  LRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNAD 856
             ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP +  P  Q  E GEAIAK+NFN D
Sbjct: 605  YKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGD 663

Query: 857  TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPP 915
            T VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+   K   DY D P
Sbjct: 664  TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLP 723

Query: 916  IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVID 973
               S S     S    + Q+   T +  Q   + F  QALY+Y P+N+DELELR+ D++D
Sbjct: 724  FSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVD 783

Query: 974  VMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            VMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 784  VMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814



 Score =  113 bits (283), Expect = 8e-25
 Identities = 78/210 (37%), Positives = 115/210 (54%), Gaps = 17/210 (8%)

Query: 6   PLQTVDRPKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP 62
           PL+  +R KDWYKTMFKQIH +++     LY+P YS          T  PLS   S  S 
Sbjct: 352 PLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSE 404

Query: 63  NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG 122
            ++ D    V       P+P      +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PG
Sbjct: 405 MSYIDGEKVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 463

Query: 123 KSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---A 178
           KSS+L +E+ +S    + + S E P      +S+F   +R+S+ A G    L ++     
Sbjct: 464 KSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYK 521

Query: 179 SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS 208
           S    G + L G S     S ++S+  S S
Sbjct: 522 SVLEGGDIPLQGLSGLKRPSSSASTKDSES 551


>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 684

 Score =  297 bits (760), Expect = 4e-80
 Identities = 156/271 (57%), Positives = 191/271 (70%), Gaps = 7/271 (2%)

Query: 738  QDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYI 796
            +D ESPR +     D   S     RR   +KE  PA+A +DFKAQT KEL  +KGD VYI
Sbjct: 415  KDSESPRHFIPA--DYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYI 472

Query: 797  LRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNAD 856
             ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP +  P  Q  E GEAIAK+NFN D
Sbjct: 473  YKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGD 531

Query: 857  TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPP 915
            T VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+   K   DY D P
Sbjct: 532  TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLP 591

Query: 916  IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVID 973
               S S     S    + Q+   T +  Q   + F  QALY+Y P+N+DELELR+ D++D
Sbjct: 592  FSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVD 651

Query: 974  VMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            VMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 652  VMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682



 Score =  113 bits (283), Expect = 8e-25
 Identities = 78/210 (37%), Positives = 115/210 (54%), Gaps = 17/210 (8%)

Query: 6   PLQTVDRPKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP 62
           PL+  +R KDWYKTMFKQIH +++     LY+P YS          T  PLS   S  S 
Sbjct: 220 PLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSE 272

Query: 63  NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG 122
            ++ D    V       P+P      +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PG
Sbjct: 273 MSYIDGEKVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 331

Query: 123 KSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---A 178
           KSS+L +E+ +S    + + S E P      +S+F   +R+S+ A G    L ++     
Sbjct: 332 KSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYK 389

Query: 179 SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS 208
           S    G + L G S     S ++S+  S S
Sbjct: 390 SVLEGGDIPLQGLSGLKRPSSSASTKDSES 419


>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
            sapiens]
          Length = 740

 Score =  291 bits (746), Expect = 2e-78
 Identities = 146/240 (60%), Positives = 178/240 (74%), Gaps = 4/240 (1%)

Query: 768  EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 827
            E  PA+A +DFKAQT KEL  +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P 
Sbjct: 500  EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 559

Query: 828  EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 887
            EKAQP +  P  Q  E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 560  EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 618

Query: 888  NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 946
            +RQGIFP++YV+V+K+   K   DY D P   S S     S    + Q+   T +  Q  
Sbjct: 619  SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTS 678

Query: 947  GEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
             + F  QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 679  QDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738



 Score =  113 bits (283), Expect = 8e-25
 Identities = 78/210 (37%), Positives = 115/210 (54%), Gaps = 17/210 (8%)

Query: 6   PLQTVDRPKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP 62
           PL+  +R KDWYKTMFKQIH +++     LY+P YS          T  PLS   S  S 
Sbjct: 220 PLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSE 272

Query: 63  NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG 122
            ++ D    V       P+P      +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PG
Sbjct: 273 MSYIDGEKVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 331

Query: 123 KSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---A 178
           KSS+L +E+ +S    + + S E P      +S+F   +R+S+ A G    L ++     
Sbjct: 332 KSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYK 389

Query: 179 SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS 208
           S    G + L G S     S ++S+  S S
Sbjct: 390 SVLEGGDIPLQGLSGLKRPSSSASTKDSES 419



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 31/188 (16%)

Query: 743 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 802
           PR+Y   L    ++ P++       E   A A ++F   T  E+SF+KG+ + +LR++D+
Sbjct: 549 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 608

Query: 803 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPPP----- 838
           NWYEG   G  R GIFPI+YV+ +                 + P ++  A P  P     
Sbjct: 609 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQR 668

Query: 839 -------AQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 891
                      ++    A Y++    + EL LR GD V ++++ D  W+ G    T + G
Sbjct: 669 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG 728

Query: 892 IFPVSYVE 899
            FP +YV+
Sbjct: 729 TFPGNYVK 736



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 7/73 (9%)

Query: 759 RERRGTPEKEKLPA-----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHG 811
           ++RR TP++ +        +A+Y +  Q   EL  + GD V ++ K D  W+ G      
Sbjct: 666 QQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTK 725

Query: 812 RVGIFPISYVEKL 824
           + G FP +YV+ L
Sbjct: 726 QFGTFPGNYVKPL 738


>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
            sapiens]
          Length = 781

 Score =  291 bits (746), Expect = 2e-78
 Identities = 146/240 (60%), Positives = 178/240 (74%), Gaps = 4/240 (1%)

Query: 768  EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 827
            E  PA+A +DFKAQT KEL  +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P 
Sbjct: 541  EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 600

Query: 828  EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 887
            EKAQP +  P  Q  E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 601  EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 659

Query: 888  NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 946
            +RQGIFP++YV+V+K+   K   DY D P   S S     S    + Q+   T +  Q  
Sbjct: 660  SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTS 719

Query: 947  GEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
             + F  QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 720  QDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779



 Score =  113 bits (283), Expect = 8e-25
 Identities = 78/210 (37%), Positives = 115/210 (54%), Gaps = 17/210 (8%)

Query: 6   PLQTVDRPKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP 62
           PL+  +R KDWYKTMFKQIH +++     LY+P YS          T  PLS   S  S 
Sbjct: 261 PLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSE 313

Query: 63  NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG 122
            ++ D    V       P+P      +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PG
Sbjct: 314 MSYIDGEKVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 372

Query: 123 KSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---A 178
           KSS+L +E+ +S    + + S E P      +S+F   +R+S+ A G    L ++     
Sbjct: 373 KSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYK 430

Query: 179 SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS 208
           S    G + L G S     S ++S+  S S
Sbjct: 431 SVLEGGDIPLQGLSGLKRPSSSASTKDSES 460



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 31/188 (16%)

Query: 743 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 802
           PR+Y   L    ++ P++       E   A A ++F   T  E+SF+KG+ + +LR++D+
Sbjct: 590 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 649

Query: 803 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPPP----- 838
           NWYEG   G  R GIFPI+YV+ +                 + P ++  A P  P     
Sbjct: 650 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQR 709

Query: 839 -------AQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 891
                      ++    A Y++    + EL LR GD V ++++ D  W+ G    T + G
Sbjct: 710 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG 769

Query: 892 IFPVSYVE 899
            FP +YV+
Sbjct: 770 TFPGNYVK 777



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 7/73 (9%)

Query: 759 RERRGTPEKEKLPA-----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHG 811
           ++RR TP++ +        +A+Y +  Q   EL  + GD V ++ K D  W+ G      
Sbjct: 707 QQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTK 766

Query: 812 RVGIFPISYVEKL 824
           + G FP +YV+ L
Sbjct: 767 QFGTFPGNYVKPL 779


>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
            sapiens]
          Length = 905

 Score =  283 bits (723), Expect = 7e-76
 Identities = 148/260 (56%), Positives = 181/260 (69%), Gaps = 24/260 (9%)

Query: 768  EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 827
            E  PA+A +DFKAQT KEL  +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P 
Sbjct: 645  EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 704

Query: 828  EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 887
            EKAQP +  P  Q  E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 705  EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 763

Query: 888  NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRI-------HSLSSN-------- 931
            +RQGIFP++YV+V+K+   K   DY D P   S S           HSL +         
Sbjct: 764  SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEK 823

Query: 932  -----KPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFV 984
                 + Q+   T +  Q   + F  QALY+Y P+N+DELELR+ D++DVMEKCDDGWFV
Sbjct: 824  SYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 883

Query: 985  GTSRRTKFFGTFPGNYVKRL 1004
            GTSRRTK FGTFPGNYVK L
Sbjct: 884  GTSRRTKQFGTFPGNYVKPL 903



 Score =  106 bits (265), Expect = 1e-22
 Identities = 58/129 (44%), Positives = 81/129 (62%), Gaps = 11/129 (8%)

Query: 6   PLQTVDRPKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP 62
           PL+  +R KDWYKTMFKQIH +++     LY+P YS          T  PLS   S  S 
Sbjct: 315 PLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSE 367

Query: 63  NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG 122
            ++ D    V       P+P      +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PG
Sbjct: 368 MSYIDGEKVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 426

Query: 123 KSSILQHER 131
           KSS+L +E+
Sbjct: 427 KSSVLTNEK 435



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 56/208 (26%), Positives = 90/208 (43%), Gaps = 51/208 (24%)

Query: 743 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 802
           PR+Y   L    ++ P++       E   A A ++F   T  E+SF+KG+ + +LR++D+
Sbjct: 694 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 753

Query: 803 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARP-------- 835
           NWYEG   G  R GIFPI+YV+ +                 + P ++  A P        
Sbjct: 754 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLR 813

Query: 836 -------------PPPAQ-----------PGEIGEAIAKYNFNADTNVELSLRKGDRVIL 871
                         P AQ             ++    A Y++    + EL LR GD V +
Sbjct: 814 AGPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 873

Query: 872 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 899
           +++ D  W+ G    T + G FP +YV+
Sbjct: 874 MEKCDDGWFVGTSRRTKQFGTFPGNYVK 901



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 37/140 (26%), Positives = 56/140 (40%), Gaps = 6/140 (4%)

Query: 689 QPLHPLPPDGAIHCPPYQN--DCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPRSY 746
           Q + P+     I  P  +N  D   +P S+S     TA+    H          ES +SY
Sbjct: 766 QGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSY 825

Query: 747 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 806
                   R  P   R    ++    +A+Y +  Q   EL  + GD V ++ K D  W+ 
Sbjct: 826 VQPQAQQRRVTPD--RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 883

Query: 807 G--EHHGRVGIFPISYVEKL 824
           G      + G FP +YV+ L
Sbjct: 884 GTSRRTKQFGTFPGNYVKPL 903


>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
            sapiens]
          Length = 671

 Score =  230 bits (587), Expect = 4e-60
 Identities = 147/410 (35%), Positives = 205/410 (50%), Gaps = 65/410 (15%)

Query: 651  KRGSLPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCG 710
            ++ S P   +L R ++EL  ++ +   ++     SP   P     P+      P      
Sbjct: 265  EKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSS 324

Query: 711  RMPRSASFQDVDTANSSCHHQDRGGA----LQDRESPRSYSSTLTDMGRSAPRERRGTPE 766
              P +       +   S H    GG+     +D   P S        G  +P  R    E
Sbjct: 325  SYPHAPYLGSARSL--SPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARRE---E 379

Query: 767  KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 826
            K++  A+  +DF+AQ+ KEL+ +KGD VYI +++D+NW EGEHHGR+GIFP +YVE L  
Sbjct: 380  KKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPA 439

Query: 827  PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 886
             E  +P + PP  Q  E GEA+A+Y F  D  VELS RKG+ + L+++V++NWYEG+I G
Sbjct: 440  DEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITG 498

Query: 887  TNRQGIFPVSYVEVVK-----------------KNTKGAEDYPDPPIPHSYSS--DRIHS 927
            T RQGIFP SYV+V +                 + T  A     P  P +  S  D I  
Sbjct: 499  TGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDL 558

Query: 928  LSSNKPQRPVFTH---------ENIQGGG---------------------------EPFQ 951
                 P+R  F+          +N+   G                            P++
Sbjct: 559  GGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYR 618

Query: 952  ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1001
            A+Y Y P+NEDELELRE D +DVM++CDDGWFVG SRRT+ FGTFPGNYV
Sbjct: 619  AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)

Query: 820  YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 879
            Y      P  +     P   +  +   A  K++F A +  EL+L+KGD V + K VD+NW
Sbjct: 358  YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 417

Query: 880  YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 939
             EG+  G  R GIFP +YVEV+      A++ P P  P +Y                   
Sbjct: 418  LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 452

Query: 940  HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 999
               +   GE   A Y +    E EL  R+ + I ++ K ++ W+ G    T   G FP +
Sbjct: 453  ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 508

Query: 1000 YVK 1002
            YV+
Sbjct: 509  YVQ 511



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 56/240 (23%), Positives = 93/240 (38%), Gaps = 36/240 (15%)

Query: 6   PLQTVDRPKDWYKTMFKQIHMVHKPGLY------NPPYSAQSHPAAKTQTYRP------- 52
           P  +VDRP+DWY+ MF+QIH    P L        PP   +   A +   +RP       
Sbjct: 136 PRSSVDRPRDWYRRMFQQIHR-KMPDLQLDWTFEEPPRDPRHLGAQQRPAHRPGPATSSS 194

Query: 53  -LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSST--EKHDWDPPDRKVDTRKF 109
             S  HS+  P +  +         + P    LR R++      +  W+   ++++T + 
Sbjct: 195 GRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQ- 253

Query: 110 RSEPRSIFEYEPGKSSI----LQHERPASLYQSSID---RSLERPMSSASMASDFRKRRK 162
              P+     +PG+       +  ER  +   + +D   R++E  + S   +   R+  +
Sbjct: 254 --RPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPE 311

Query: 163 SEPAVGPPRGLGDQ--------SASRTSPGRVDLPGSSTTLTKSFT-SSSPSSPSRAKGG 213
             P  GP               SA   SP ++   GS     + F   SS   PS + GG
Sbjct: 312 QRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGG 371



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 20/53 (37%), Positives = 29/53 (54%)

Query: 849 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 901
           A Y +      EL LR+GDRV ++++ D  W+ G    T + G FP +YV  V
Sbjct: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671


>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
            sapiens]
          Length = 329

 Score =  228 bits (581), Expect = 2e-59
 Identities = 130/314 (41%), Positives = 173/314 (55%), Gaps = 59/314 (18%)

Query: 743  PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 802
            P S        G  +P  R    EK++  A+  +DF+AQ+ KEL+ +KGD VYI +++D+
Sbjct: 17   PSSTRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDK 73

Query: 803  NWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELS 862
            NW EGEHHGR+GIFP +YVE L   E  +P + PP  Q  E GEA+A+Y F  D  VELS
Sbjct: 74   NWLEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELS 132

Query: 863  LRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK-----------------KNT 905
             RKG+ + L+++V++NWYEG+I GT RQGIFP SYV+V +                 + T
Sbjct: 133  FRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLT 192

Query: 906  KGAEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG------- 947
              A     P  P +  S  D I       P+R  F+          +N+   G       
Sbjct: 193  AAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSR 252

Query: 948  --------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTS 987
                                 P++A+Y Y P+NEDELELRE D +DVM++CDDGWFVG S
Sbjct: 253  GPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVS 312

Query: 988  RRTKFFGTFPGNYV 1001
            RRT+ FGTFPGNYV
Sbjct: 313  RRTQKFGTFPGNYV 326



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)

Query: 820  YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 879
            Y      P  +     P   +  +   A  K++F A +  EL+L+KGD V + K VD+NW
Sbjct: 16   YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 75

Query: 880  YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 939
             EG+  G  R GIFP +YVEV+      A++ P P  P +Y                   
Sbjct: 76   LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 110

Query: 940  HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 999
               +   GE   A Y +    E EL  R+ + I ++ K ++ W+ G    T   G FP +
Sbjct: 111  ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 166

Query: 1000 YVK 1002
            YV+
Sbjct: 167  YVQ 169



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 43/159 (27%), Positives = 66/159 (41%), Gaps = 23/159 (14%)

Query: 669 LPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRM--PRSA--SFQDVDTA 724
           LP  P   ++ R+ R        HP  P  A+  P    D G    PR    SF   +  
Sbjct: 185 LPTSPRLTAAARSAR--------HPSSPS-ALRSPADPIDLGGQTSPRRTGFSFPTQEPR 235

Query: 725 NSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSK 784
             + +    G AL     P    S   D+G S+P     T +    P +A+Y ++ Q   
Sbjct: 236 PQTQNLGTPGPALSHSRGP----SHPLDLGTSSPN----TSQIHWTPYRAMYQYRPQNED 287

Query: 785 ELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYV 821
           EL  ++GD V ++++ D  W+ G      + G FP +YV
Sbjct: 288 ELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 20/53 (37%), Positives = 29/53 (54%)

Query: 849 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 901
           A Y +      EL LR+GDRV ++++ D  W+ G    T + G FP +YV  V
Sbjct: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329


>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
           sapiens]
          Length = 1151

 Score =  201 bits (510), Expect = 4e-51
 Identities = 101/182 (55%), Positives = 128/182 (70%), Gaps = 2/182 (1%)

Query: 768 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 827
           E  PA+A +DFKAQT KEL  +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P 
Sbjct: 816 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 875

Query: 828 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 887
           EKAQP +  P  Q  E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 876 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 934

Query: 888 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 946
           +RQGIFP++YV+V+K+   K   DY D P   S S     S    + +   +  +  +G 
Sbjct: 935 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGA 994

Query: 947 GE 948
           GE
Sbjct: 995 GE 996



 Score =  148 bits (373), Expect = 3e-35
 Identities = 105/298 (35%), Positives = 146/298 (48%), Gaps = 49/298 (16%)

Query: 743  PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 802
            PR+Y   L    ++ P++       E   A A ++F   T  E+SF+KG+ + +LR++D+
Sbjct: 865  PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 924

Query: 803  NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPP------ 837
            NWYEG   G  R GIFPI+YV+ +                 + P ++  A P P      
Sbjct: 925  NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984

Query: 838  ---------PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 888
                       + G  G  I+K +    ++V   L    R+      D N  E   PG  
Sbjct: 985  QYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLS-----DLNTPEESRPGKP 1039

Query: 889  RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 948
                FP S  E  +++  G +           ++ R  S      QR V T +  Q   +
Sbjct: 1040 LGSAFPGSEAEQTERHRGGEQ-------AGRKAARRGGSQQPQAQQRRV-TPDRSQTSQD 1091

Query: 949  PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
             F  QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1092 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 59/189 (31%), Positives = 83/189 (43%), Gaps = 63/189 (33%)

Query: 6   PLQTVDRPKDWYKTMFKQIHMVHK----PGLYNPPYSAQSHPAAKTQTYRPLSKS----- 56
           PL+  +R KDWYKTMFKQIH +++       Y P Y     P  +  +    S S     
Sbjct: 384 PLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEETKSCSVMSPR 443

Query: 57  ----------------HSDNSPNA---------------------FKDASSPVPPPHVPP 79
                            S N P +                      +D  SP+  P    
Sbjct: 444 LECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSDLYSPRYSFSEDTKSPLSVPRSKS 503

Query: 80  PVP--------------PLRPRDRS---STEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG 122
            +               PL  R  S   S+E++DW+PPD+KVDTRK+R+EP+SI+EY+PG
Sbjct: 504 EMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 563

Query: 123 KSSILQHER 131
           KSS+L +E+
Sbjct: 564 KSSVLTNEK 572



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 15/119 (12%)

Query: 713  PRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA 772
            P  ++F   +   +  H   RGG    R++ R   S      +   ++RR TP++ +   
Sbjct: 1039 PLGSAFPGSEAEQTERH---RGGEQAGRKAARRGGSQ-----QPQAQQRRVTPDRSQTSQ 1090

Query: 773  -----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 824
                 +A+Y +  Q   EL  + GD V ++ K D  W+ G      + G FP +YV+ L
Sbjct: 1091 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149



 Score = 31.6 bits (70), Expect = 3.9
 Identities = 14/56 (25%), Positives = 29/56 (51%), Gaps = 2/56 (3%)

Query: 949  PFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            P +A +++  +   EL L++ D++ + ++ D  W+ G        G FP  Y++ L
Sbjct: 819  PARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR--VGIFPRTYIELL 872


>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
           sapiens]
          Length = 1292

 Score =  199 bits (505), Expect = 1e-50
 Identities = 97/155 (62%), Positives = 119/155 (76%), Gaps = 2/155 (1%)

Query: 768 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 827
           E  PA+A +DFKAQT KEL  +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P 
Sbjct: 794 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 853

Query: 828 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 887
           EKAQP +  P  Q  E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 854 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 912

Query: 888 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYS 921
           +RQGIFP++YV+V+K+   K   DY D P   S S
Sbjct: 913 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPS 947



 Score =  102 bits (254), Expect = 2e-21
 Identities = 44/55 (80%), Positives = 51/55 (92%)

Query: 950  FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            +QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290



 Score =  100 bits (249), Expect = 7e-21
 Identities = 59/167 (35%), Positives = 86/167 (51%), Gaps = 41/167 (24%)

Query: 6   PLQTVDRPKDWYKTMFKQIHMVHKPGLYNPPY---------------SAQSHPAAKTQTY 50
           PL+  +R KDWYKTMFKQIH +++      PY               S + +P   T  +
Sbjct: 384 PLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEEDNPYTPTYQF 443

Query: 51  ---RPLSKSHSDNSP------NAFKDASSPVPPPHVPP-----------------PVPPL 84
               P  KS  D+S       +  +D  SP+  P                     P+P  
Sbjct: 444 PASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPAR 503

Query: 85  RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER 131
               +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 504 SSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEK 550



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 51/159 (32%), Positives = 76/159 (47%), Gaps = 29/159 (18%)

Query: 843  EIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 902
            E+  A AK++F A T  EL L+KGD V + K++DQNWYEG+  G  R GIFP +Y+E++ 
Sbjct: 794  EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELL- 850

Query: 903  KNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 962
                       PP              + K Q    T   +   GE   A +N+    + 
Sbjct: 851  -----------PP--------------AEKAQPKKLTPVQVLEYGEAI-AKFNFNGDTQV 884

Query: 963  ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1001
            E+  R+ + I ++ + D+ W+ G    T   G FP  YV
Sbjct: 885  EMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 923



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 2/92 (2%)

Query: 743 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 802
           PR+Y   L    ++ P++       E   A A ++F   T  E+SF+KG+ + +LR++D+
Sbjct: 843 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 902

Query: 803 NWYEGEHHG--RVGIFPISYVEKLTPPEKAQP 832
           NWYEG   G  R GIFPI+YV+ +  P    P
Sbjct: 903 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNP 934



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 15/119 (12%)

Query: 713  PRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA 772
            P  ++F   +   +  H   RGG    R++ R   S      +   ++RR TP++ +   
Sbjct: 1180 PLGSAFPGSEAEQTERH---RGGEQAGRKAARRGGSQ-----QPQAQQRRVTPDRSQTSQ 1231

Query: 773  -----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 824
                 +A+Y +  Q   EL  + GD V ++ K D  W+ G      + G FP +YV+ L
Sbjct: 1232 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290



 Score = 38.1 bits (87), Expect = 0.042
 Identities = 18/51 (35%), Positives = 29/51 (56%)

Query: 849  AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 899
            A Y++    + EL LR GD V ++++ D  W+ G    T + G FP +YV+
Sbjct: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288


>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
          Length = 731

 Score =  101 bits (252), Expect = 3e-21
 Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)

Query: 772  AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 830
            A  ++DF A+   +L+   G+ VY+L KID +WY G    ++GIFP +YV+ +   PE  
Sbjct: 441  AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 500

Query: 831  QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 890
               R    +   +    +A++ +  +   ELS  +G+ +IL + V++ W  G++ G  R 
Sbjct: 501  NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 558

Query: 891  GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 949
            GIFP+++VE V       EDYP        S   + S       +   +  N Q    P 
Sbjct: 559  GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 604

Query: 950  --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
               +AL+++T    D+L  +  D I ++E+ D  W  G  +  +  G FP  +V+
Sbjct: 605  EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 657



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)

Query: 770 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 826
           LPA+   A++ F A+TS +LSFK+GD + IL ++D +W  G    R GIFP  +V     
Sbjct: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661

Query: 827 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 886
             K+  A  P         +A A Y+F  +   ELS + GD +  L+ VD +W  G++ G
Sbjct: 662 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 715

Query: 887 TNRQGIFPVSYVEVVK 902
             + GIFP +Y++ ++
Sbjct: 716 --KSGIFPKNYIQFLQ 729



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 57/221 (25%), Positives = 99/221 (44%), Gaps = 36/221 (16%)

Query: 788  FKKGDTVYILRKIDQNWYE---GEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEI 844
            + +GD + +L++ + N+ E   GE  GRV +  +  +  L    +++P  P    +P + 
Sbjct: 377  YMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDS 436

Query: 845  G--EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 902
            G   A+  ++F A+   +L+L  G+ V LL+++D +WY G     N+ GIFP +YV+V+ 
Sbjct: 437  GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVII 494

Query: 903  KNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 962
               +G     +    H     R                           A + Y    +D
Sbjct: 495  DIPEGGNGKRECVSSHCVKGSRC-------------------------VARFEYIGEQKD 529

Query: 963  ELELRESDVIDVMEKCDDGWFVGTSR-RTKFFGTFPGNYVK 1002
            EL   E ++I + E  ++ W  G  R RT   G FP N+V+
Sbjct: 530  ELSFSEGEIIILKEYVNEEWARGEVRGRT---GIFPLNFVE 567



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 36/94 (38%), Positives = 50/94 (53%), Gaps = 11/94 (11%)

Query: 735 GALQDRESPRSYSSTLTDMGRSAPRERRG----TPEKEKLPAKAVYDFKAQTSKELSFKK 790
           G LQDRE    + +      R  P E +      P+  K  AKA+YDF+ +   ELSFK 
Sbjct: 642 GRLQDREG--IFPAVFV---RPCPAEAKSMLAIVPKGRK--AKALYDFRGENEDELSFKA 694

Query: 791 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 824
           GD +  L  +D +W  GE  G+ GIFP +Y++ L
Sbjct: 695 GDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728


>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
          Length = 767

 Score =  101 bits (252), Expect = 3e-21
 Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)

Query: 772  AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 830
            A  ++DF A+   +L+   G+ VY+L KID +WY G    ++GIFP +YV+ +   PE  
Sbjct: 477  AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 536

Query: 831  QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 890
               R    +   +    +A++ +  +   ELS  +G+ +IL + V++ W  G++ G  R 
Sbjct: 537  NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 594

Query: 891  GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 949
            GIFP+++VE V       EDYP        S   + S       +   +  N Q    P 
Sbjct: 595  GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 640

Query: 950  --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
               +AL+++T    D+L  +  D I ++E+ D  W  G  +  +  G FP  +V+
Sbjct: 641  EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 693



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)

Query: 770 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 826
           LPA+   A++ F A+TS +LSFK+GD + IL ++D +W  G    R GIFP  +V     
Sbjct: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697

Query: 827 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 886
             K+  A  P         +A A Y+F  +   ELS + GD +  L+ VD +W  G++ G
Sbjct: 698 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 751

Query: 887 TNRQGIFPVSYVEVVK 902
             + GIFP +Y++ ++
Sbjct: 752 --KSGIFPKNYIQFLQ 765



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 57/221 (25%), Positives = 99/221 (44%), Gaps = 36/221 (16%)

Query: 788  FKKGDTVYILRKIDQNWYE---GEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEI 844
            + +GD + +L++ + N+ E   GE  GRV +  +  +  L    +++P  P    +P + 
Sbjct: 413  YMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDS 472

Query: 845  G--EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 902
            G   A+  ++F A+   +L+L  G+ V LL+++D +WY G     N+ GIFP +YV+V+ 
Sbjct: 473  GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVII 530

Query: 903  KNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 962
               +G     +    H     R                           A + Y    +D
Sbjct: 531  DIPEGGNGKRECVSSHCVKGSRC-------------------------VARFEYIGEQKD 565

Query: 963  ELELRESDVIDVMEKCDDGWFVGTSR-RTKFFGTFPGNYVK 1002
            EL   E ++I + E  ++ W  G  R RT   G FP N+V+
Sbjct: 566  ELSFSEGEIIILKEYVNEEWARGEVRGRT---GIFPLNFVE 603



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 36/94 (38%), Positives = 50/94 (53%), Gaps = 11/94 (11%)

Query: 735 GALQDRESPRSYSSTLTDMGRSAPRERRG----TPEKEKLPAKAVYDFKAQTSKELSFKK 790
           G LQDRE    + +      R  P E +      P+  K  AKA+YDF+ +   ELSFK 
Sbjct: 678 GRLQDREG--IFPAVFV---RPCPAEAKSMLAIVPKGRK--AKALYDFRGENEDELSFKA 730

Query: 791 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 824
           GD +  L  +D +W  GE  G+ GIFP +Y++ L
Sbjct: 731 GDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764


>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
          Length = 790

 Score =  101 bits (252), Expect = 3e-21
 Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)

Query: 772  AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 830
            A  ++DF A+   +L+   G+ VY+L KID +WY G    ++GIFP +YV+ +   PE  
Sbjct: 500  AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 559

Query: 831  QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 890
               R    +   +    +A++ +  +   ELS  +G+ +IL + V++ W  G++ G  R 
Sbjct: 560  NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 617

Query: 891  GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 949
            GIFP+++VE V       EDYP        S   + S       +   +  N Q    P 
Sbjct: 618  GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 663

Query: 950  --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
               +AL+++T    D+L  +  D I ++E+ D  W  G  +  +  G FP  +V+
Sbjct: 664  EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 716



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)

Query: 770 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 826
           LPA+   A++ F A+TS +LSFK+GD + IL ++D +W  G    R GIFP  +V     
Sbjct: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720

Query: 827 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 886
             K+  A  P         +A A Y+F  +   ELS + GD +  L+ VD +W  G++ G
Sbjct: 721 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 774

Query: 887 TNRQGIFPVSYVEVVK 902
             + GIFP +Y++ ++
Sbjct: 775 --KSGIFPKNYIQFLQ 788



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 68/256 (26%), Positives = 112/256 (43%), Gaps = 41/256 (16%)

Query: 758  PRERRGTPEKEKLPAKAVY-----DFKAQTSKELSFKKGDTVYILRKIDQNWYE---GEH 809
            PR + G P   K      +     D  +Q   ELS K+GD + +L++ + N+ E   GE 
Sbjct: 401  PRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGED 460

Query: 810  HGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIG--EAIAKYNFNADTNVELSLRKGD 867
             GRV +  +  +  L    +++P  P    +P + G   A+  ++F A+   +L+L  G+
Sbjct: 461  TGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGE 520

Query: 868  RVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHS 927
             V LL+++D +WY G     N+ GIFP +YV+V+    +G     +    H     R   
Sbjct: 521  IVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRC-- 576

Query: 928  LSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTS 987
                                    A + Y    +DEL   E ++I + E  ++ W  G  
Sbjct: 577  -----------------------VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV 613

Query: 988  R-RTKFFGTFPGNYVK 1002
            R RT   G FP N+V+
Sbjct: 614  RGRT---GIFPLNFVE 626



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 50/250 (20%), Positives = 100/250 (40%), Gaps = 30/250 (12%)

Query: 754  GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRV 813
            G++ P ++  T    + P         +++K+L F +  +   L+K   N   G    + 
Sbjct: 330  GKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKS 389

Query: 814  GIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLK 873
             +F     + + PP + +P  P        +   IA  +  +    ELS ++GD +++LK
Sbjct: 390  QVFKNQ--DPVLPP-RPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKRGDVLVMLK 446

Query: 874  RVDQNWYE-GKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 932
            + + N+ E  K   T R  +  +  +  + ++ +                        ++
Sbjct: 447  QTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR------------------------SR 482

Query: 933  PQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKF 992
            P  P    + +  G      L+++     D+L L   +++ ++EK D  W+ G  R    
Sbjct: 483  PNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ-- 540

Query: 993  FGTFPGNYVK 1002
             G FP NYVK
Sbjct: 541  IGIFPANYVK 550



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 36/94 (38%), Positives = 50/94 (53%), Gaps = 11/94 (11%)

Query: 735 GALQDRESPRSYSSTLTDMGRSAPRERRG----TPEKEKLPAKAVYDFKAQTSKELSFKK 790
           G LQDRE    + +      R  P E +      P+  K  AKA+YDF+ +   ELSFK 
Sbjct: 701 GRLQDREG--IFPAVFV---RPCPAEAKSMLAIVPKGRK--AKALYDFRGENEDELSFKA 753

Query: 791 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 824
           GD +  L  +D +W  GE  G+ GIFP +Y++ L
Sbjct: 754 GDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787


>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
          Length = 888

 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 61/187 (32%), Positives = 98/187 (52%), Gaps = 25/187 (13%)

Query: 744 RSYSSTLTD---------MGRSAPRERRGTPEKEKLP----AKAVYDFKAQTSKELSFKK 790
           RS SST+ +          G   PR +  +P    +P    AKA+Y+++ +   +L F K
Sbjct: 98  RSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSK 157

Query: 791 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK 850
           GD + + R++D+NWY GE +G  G FP ++V+ + P        P PP Q   + +   K
Sbjct: 158 GDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKP-------LPQPPPQCKALYDFEVK 210

Query: 851 YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAED 910
            +  AD +  L   K D + +++RVD+NW EG +   ++ GIFP+SYVE      K   +
Sbjct: 211 -DKEADKDC-LPFAKDDVLTVIRRVDENWAEGML--ADKIGIFPISYVE-FNSAAKQLIE 265

Query: 911 YPDPPIP 917
           +  PP+P
Sbjct: 266 WDKPPVP 272



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 31/52 (59%), Positives = 37/52 (71%)

Query: 950  FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1001
            + A+Y YTPR EDELELR+ ++  V E+C DGWF GTS  T   G FPGNYV
Sbjct: 450  YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 24/57 (42%), Positives = 39/57 (68%)

Query: 948  EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            E  + + +Y P++E ELEL+E D++ V +K +DGWF GT +R    G FPG++V+ +
Sbjct: 832  ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)

Query: 848 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 907
           +A Y +      EL LRKG+  ++ +R    W++G    T++ G+FP +YV  V   T+ 
Sbjct: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV---TRA 507

Query: 908 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 947
             +     +P S +      ++   P       + +QG G
Sbjct: 508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 18/54 (33%), Positives = 34/54 (62%), Gaps = 2/54 (3%)

Query: 773 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 824
           + V  +  Q+  EL  K+GD V++ +K +  W++G  + +G+ G+FP S+VE +
Sbjct: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 28/123 (22%), Positives = 50/123 (40%), Gaps = 30/123 (24%)

Query: 807 GEHHGRVGIFPI------------------SYVEKLTPPEKAQPARPPPPAQPGEIGEAI 848
           G  HGR G  P+                  ++  K +  + A P  PPP      +G  +
Sbjct: 764 GGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVL 823

Query: 849 AK------------YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 896
            +             ++   +  EL L++GD V + K+ +  W++G +    + G+FP S
Sbjct: 824 NESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGS 883

Query: 897 YVE 899
           +VE
Sbjct: 884 FVE 886



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 2/54 (3%)

Query: 774 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLT 825
           A+Y +  +   EL  +KG+   +  +    W++G   H  ++G+FP +YV  +T
Sbjct: 452 AIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505



 Score = 34.7 bits (78), Expect = 0.46
 Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)

Query: 951  QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
            +ALYNY  +   +L+  + D+I +  + D+ W+ G        G FP N+V+
Sbjct: 140  KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHG--EVNGIHGFFPTNFVQ 189


>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
          Length = 882

 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%)

Query: 773  KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 822
            KA+YDF    K Q    L+F K + + +LR++D+NW EG    ++GIFP+ YVE      
Sbjct: 262  KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321

Query: 823  KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 877
            +L   +K  PA         P+  G +         ++   V    R+ D     K+   
Sbjct: 322  QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381

Query: 878  NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 932
                   +      ++R  +   + V +   + + A    D  + H   +     +SS+ 
Sbjct: 382  FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439

Query: 933  PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 980
               P          GE             + ALY Y P+  DELEL + ++  V+EKC D
Sbjct: 440  GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499

Query: 981  GWFVGTSRRTKFFGTFPGNYV 1001
            GWF G S RT   G FPGNYV
Sbjct: 500  GWFKGASLRTGVSGVFPGNYV 520



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 21/154 (13%)

Query: 773 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 832
           KA+Y ++ +   +L F KGD + + RK+D+ WY GE HG  G  P SY++ + P   A P
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259

Query: 833 ARPPPPAQPGEIGEAIAKYNFNADTNVE----LSLRKGDRVILLKRVDQNWYEGKIPGTN 888
                        +  A Y+F      +    L+  K + + +L+RVD+NW EG +   +
Sbjct: 260 -------------QGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GD 304

Query: 889 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSS 922
           + GIFP+ YVE+     +  E   D P P + SS
Sbjct: 305 KIGIFPLLYVELNDSAKQLIE--MDKPCPAAASS 336



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 22/55 (40%), Positives = 39/55 (70%)

Query: 948  EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
            E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R    G FPG++V+
Sbjct: 826  ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 42/179 (23%), Positives = 74/179 (41%), Gaps = 47/179 (26%)

Query: 828  EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 887
            E A     P    P  +    A Y++      +L   KGD ++L ++VD+ WY G++ GT
Sbjct: 180  ELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGT 239

Query: 888  NRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 947
              QG  P SY++ ++            P+PH+             PQ             
Sbjct: 240  --QGFLPASYIQCIQ------------PLPHA------------PPQG------------ 261

Query: 948  EPFQALYNYTPRNEDE----LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
               +ALY++  +++D+    L   + +++ V+ + D+ W  G        G FP  YV+
Sbjct: 262  ---KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDK--IGIFPLLYVE 315



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 46/144 (31%), Positives = 66/144 (45%), Gaps = 17/144 (11%)

Query: 713 PRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLP 771
           PR+A+ +  D A+ SC       A   ++   S  ST T + R+A     +GTP K +LP
Sbjct: 414 PRAAA-RIGDLAHLSC-------AAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLP 465

Query: 772 AK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTP 826
                A+Y +K Q S EL   KG+   +L K    W++G     G  G+FP +YV   TP
Sbjct: 466 LNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TP 522

Query: 827 PEKAQPARPPPPAQPGEIGEAIAK 850
             +       PP      G  +AK
Sbjct: 523 VSRVPAGGAGPPRNNVVGGSPLAK 546



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 6/84 (7%)

Query: 745 SYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSFKKGDTVYILRKI 800
           S     T   R AP       PE + LP    + V  +  Q+  E+  K+GD V++ +K 
Sbjct: 797 SLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR 856

Query: 801 DQNWYEG--EHHGRVGIFPISYVE 822
           +  WY+G  + +GR G+FP S+VE
Sbjct: 857 EDGWYKGTLQRNGRTGLFPGSFVE 880



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%)

Query: 806 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 855
           E E  G +G+ P+     S     T P +  P      RP P   P E    +  Y   +
Sbjct: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838

Query: 856 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 899
           +  +EL  ++GD V + K+ +  WY+G +    R G+FP S+VE
Sbjct: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 21/76 (27%), Positives = 34/76 (44%)

Query: 837 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 896
           PP     +   +A Y +    + EL L KG+   +L++    W++G    T   G+FP +
Sbjct: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518

Query: 897 YVEVVKKNTKGAEDYP 912
           YV  V +   G    P
Sbjct: 519 YVTPVSRVPAGGAGPP 534


>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
            sapiens]
          Length = 756

 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 33/243 (13%)

Query: 778  FKAQTSKELSFKKGDTVYILRKID-QNWYEGEHHGRVGIFPISYVEKLTPP--------- 827
            ++AQ   ELS   GD V  +R +  + W  GE  GR G+FP   V+++            
Sbjct: 9    YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68

Query: 828  -----EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEG 882
                  +  PA+ P P +  ++      ++++ +   EL L+ G+ V ++K ++  W+ G
Sbjct: 69   PRCARRRGHPAKHPRPQRWCKVN-----FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123

Query: 883  KIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI--PHSYSSDRIHSLSSNKPQRPVFTH 940
            K  G  + G FP ++VE++        + PD P   P      ++ SL+ + P   + T 
Sbjct: 124  KKNG--QLGAFPSNFVELLDSGPPSLGN-PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180

Query: 941  ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPG 998
             +     E ++ L++Y P   DEL LR  DV+ V+ K   D GW+ G  +  +  G FP 
Sbjct: 181  SH----PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPD 234

Query: 999  NYV 1001
            N+V
Sbjct: 235  NFV 237



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 30/166 (18%)

Query: 761 RRGTPEKEKLP---AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 817
           RRG P K   P    K  + +  + + EL  + G+ V ++++I+  W+ G+ +G++G FP
Sbjct: 74  RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133

Query: 818 ISYVEKLT--PPEKAQPARP---PPPAQPGEIGEAI------------------AKYNFN 854
            ++VE L   PP    P  P   P P +P ++                        +++ 
Sbjct: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193

Query: 855 ADTNVELSLRKGDRVILLKRV--DQNWYEGKIPGTNRQGIFPVSYV 898
            +   EL+LR+GD V +L +   D+ W+EG+  G  R+G+FP ++V
Sbjct: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFV 237



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 22/160 (13%)

Query: 846  EAIAKYNFNADTNVELSLRKGDRVILLKRVD-QNWYEGKIPGTNRQGIFPVSYVEVVKKN 904
            E +    + A    ELSL  GD V  ++ V  + W  G+  G  R G+FP   V+ + + 
Sbjct: 2    EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59

Query: 905  TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDEL 964
             +G+ +   P         R H     +PQR    +             ++Y+P   DEL
Sbjct: 60   LRGSGEARRPRCARR----RGHPAKHPRPQRWCKVN-------------FSYSPEQADEL 102

Query: 965  ELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            +L+  ++++++++ +DGW++G  ++    G FP N+V+ L
Sbjct: 103  KLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 22/64 (34%), Positives = 39/64 (60%), Gaps = 2/64 (3%)

Query: 773 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 830
           + ++D++ +   EL+ ++GD V +L K   D+ W+EGE  GR G+FP ++V    P +K 
Sbjct: 187 RVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKL 246

Query: 831 QPAR 834
            P +
Sbjct: 247 VPRK 250


>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
          Length = 1220

 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 78/268 (29%), Positives = 127/268 (47%), Gaps = 51/268 (19%)

Query: 756  SAPRERRGTPEK-EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVG 814
            S+P    G  EK E L A+A+Y ++A+    L+F K D + +L + D  W+ GE  G+ G
Sbjct: 901  SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKG 959

Query: 815  IFPISYVEKLTPP----------EKAQPAR----PPPPAQPGEIGEA-IAKYNFNADTNV 859
             FP SYV+ ++ P              PA       P A+P   GE  IA Y + +    
Sbjct: 960  WFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQG 1019

Query: 860  ELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHS 919
            +L+ ++GD VIL+ + D +W+ G +   ++ G+FP +YV +  K+++G           S
Sbjct: 1020 DLTFQQGD-VILVTKKDGDWWTGTVG--DKAGVFPSNYVRL--KDSEG-----------S 1063

Query: 920  YSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCD 979
             ++ +  SL   KP              E  Q + +YT    ++L L    +I + +K  
Sbjct: 1064 GTAGKTGSLGK-KP--------------EIAQVIASYTATGPEQLTLAPGQLILIRKKNP 1108

Query: 980  DGWFVGTSR---RTKFFGTFPGNYVKRL 1004
             GW+ G  +   + +  G FP NYVK L
Sbjct: 1109 GGWWEGELQARGKKRQIGWFPANYVKLL 1136



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 33/232 (14%)

Query: 774  AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 833
            A+Y +++    +L+F++GD + + +K D +W+ G    + G+FP +YV            
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067

Query: 834  RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP--GTNRQ- 890
            +     +  EI + IA Y   A    +L+L  G  +++ K+    W+EG++   G  RQ 
Sbjct: 1068 KTGSLGKKPEIAQVIASYT--ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125

Query: 891  GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF 950
            G FP +YV+++   T                      ++  +P +        Q  G   
Sbjct: 1126 GWFPANYVKLLSPGTS--------------------KITPTEPPKSTALAAVCQVIG--- 1162

Query: 951  QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
              +Y+YT +N+DEL   +  +I+V+ K D  W+ G        G FP NYVK
Sbjct: 1163 --MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ--VGLFPSNYVK 1210



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)

Query: 750  LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 809
            L D   S    + G+  K+   A+ +  + A   ++L+   G  + I +K    W+EGE 
Sbjct: 1057 LKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGEL 1116

Query: 810  HGR-----VGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL 863
              R     +G FP +YV+ L+P   K  P  PP       + + I  Y++ A  + EL+ 
Sbjct: 1117 QARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF 1176

Query: 864  RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 900
             KG  + +L + D +W++G++ G  + G+FP +YV++
Sbjct: 1177 NKGQIINVLNKEDPDWWKGEVNG--QVGLFPSNYVKL 1211



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 54/179 (30%), Positives = 80/179 (44%), Gaps = 20/179 (11%)

Query: 827  PEKAQPARPPPPAQPGEIGEAI---AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGK 883
            P  A  + P P    GE  E +   A Y + A  +  L+  K D + +L++ D  W+ G+
Sbjct: 895  PATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GE 953

Query: 884  IPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENI 943
            + G  ++G FP SYV+++             PI  S S D   S S    +R        
Sbjct: 954  VQG--QKGWFPKSYVKLISG-----------PIRKSTSMDSGSSESPASLKRVASPAAKP 1000

Query: 944  QGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
               GE F A+Y Y    + +L  ++ DVI V +K D  W+ GT       G FP NYV+
Sbjct: 1001 VVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKA--GVFPSNYVR 1056



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 24/57 (42%), Positives = 39/57 (68%)

Query: 775  VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 831
            +YD+ AQ   EL+F KG  + +L K D +W++GE +G+VG+FP +YV+  T  + +Q
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 34/243 (13%)

Query: 773  KAVYDFKAQTSKELSFKKGDTVYILRK-IDQN------WYEGEHHGRVGIFPISYVEKLT 825
            +A+Y F++++  E++ + GD V +  + +D++      W  GE  G+ G FP +Y EK+ 
Sbjct: 746  RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805

Query: 826  PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 885
              E   P +P   +      +   +     +T   L++   +          NW      
Sbjct: 806  ENEVPAPVKPVTDSTSAPAPKLALR-----ETPAPLAVTSSEP----STTPNNW------ 850

Query: 886  GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHEN-IQ 944
              +    +P S  E  K  T   + +   P     S+ ++   S+  P     +  + + 
Sbjct: 851  -ADFSSTWPTSTNE--KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL 907

Query: 945  GGGEPF-----QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 999
            G GE       QALY +  + ++ L   ++DVI V+E+ D  WF G  +  K  G FP +
Sbjct: 908  GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQK--GWFPKS 964

Query: 1000 YVK 1002
            YVK
Sbjct: 965  YVK 967



 Score = 32.0 bits (71), Expect = 3.0
 Identities = 16/62 (25%), Positives = 31/62 (50%), Gaps = 9/62 (14%)

Query: 950  FQALYNYTPRNEDELELRESDV-------IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
            ++ALY +  R+ DE+ ++  D+       +D  +  + GW  G  +     G FP NY +
Sbjct: 745  YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT--GWFPANYAE 802

Query: 1003 RL 1004
            ++
Sbjct: 803  KI 804


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 78/268 (29%), Positives = 127/268 (47%), Gaps = 51/268 (19%)

Query: 756  SAPRERRGTPEK-EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVG 814
            S+P    G  EK E L A+A+Y ++A+    L+F K D + +L + D  W+ GE  G+ G
Sbjct: 901  SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKG 959

Query: 815  IFPISYVEKLTPP----------EKAQPAR----PPPPAQPGEIGEA-IAKYNFNADTNV 859
             FP SYV+ ++ P              PA       P A+P   GE  IA Y + +    
Sbjct: 960  WFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQG 1019

Query: 860  ELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHS 919
            +L+ ++GD VIL+ + D +W+ G +   ++ G+FP +YV +  K+++G           S
Sbjct: 1020 DLTFQQGD-VILVTKKDGDWWTGTVG--DKAGVFPSNYVRL--KDSEG-----------S 1063

Query: 920  YSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCD 979
             ++ +  SL   KP              E  Q + +YT    ++L L    +I + +K  
Sbjct: 1064 GTAGKTGSLGK-KP--------------EIAQVIASYTATGPEQLTLAPGQLILIRKKNP 1108

Query: 980  DGWFVGTSR---RTKFFGTFPGNYVKRL 1004
             GW+ G  +   + +  G FP NYVK L
Sbjct: 1109 GGWWEGELQARGKKRQIGWFPANYVKLL 1136



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 33/232 (14%)

Query: 774  AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 833
            A+Y +++    +L+F++GD + + +K D +W+ G    + G+FP +YV            
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067

Query: 834  RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP--GTNRQ- 890
            +     +  EI + IA Y   A    +L+L  G  +++ K+    W+EG++   G  RQ 
Sbjct: 1068 KTGSLGKKPEIAQVIASYT--ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125

Query: 891  GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF 950
            G FP +YV+++   T                      ++  +P +        Q  G   
Sbjct: 1126 GWFPANYVKLLSPGTS--------------------KITPTEPPKSTALAAVCQVIG--- 1162

Query: 951  QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
              +Y+YT +N+DEL   +  +I+V+ K D  W+ G        G FP NYVK
Sbjct: 1163 --MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ--VGLFPSNYVK 1210



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)

Query: 750  LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 809
            L D   S    + G+  K+   A+ +  + A   ++L+   G  + I +K    W+EGE 
Sbjct: 1057 LKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGEL 1116

Query: 810  HGR-----VGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL 863
              R     +G FP +YV+ L+P   K  P  PP       + + I  Y++ A  + EL+ 
Sbjct: 1117 QARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF 1176

Query: 864  RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 900
             KG  + +L + D +W++G++ G  + G+FP +YV++
Sbjct: 1177 NKGQIINVLNKEDPDWWKGEVNG--QVGLFPSNYVKL 1211



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 54/179 (30%), Positives = 80/179 (44%), Gaps = 20/179 (11%)

Query: 827  PEKAQPARPPPPAQPGEIGEAI---AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGK 883
            P  A  + P P    GE  E +   A Y + A  +  L+  K D + +L++ D  W+ G+
Sbjct: 895  PATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GE 953

Query: 884  IPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENI 943
            + G  ++G FP SYV+++             PI  S S D   S S    +R        
Sbjct: 954  VQG--QKGWFPKSYVKLISG-----------PIRKSTSMDSGSSESPASLKRVASPAAKP 1000

Query: 944  QGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
               GE F A+Y Y    + +L  ++ DVI V +K D  W+ GT       G FP NYV+
Sbjct: 1001 VVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKA--GVFPSNYVR 1056



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 24/57 (42%), Positives = 39/57 (68%)

Query: 775  VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 831
            +YD+ AQ   EL+F KG  + +L K D +W++GE +G+VG+FP +YV+  T  + +Q
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 34/243 (13%)

Query: 773  KAVYDFKAQTSKELSFKKGDTVYILRK-IDQN------WYEGEHHGRVGIFPISYVEKLT 825
            +A+Y F++++  E++ + GD V +  + +D++      W  GE  G+ G FP +Y EK+ 
Sbjct: 746  RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805

Query: 826  PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 885
              E   P +P   +      +   +     +T   L++   +          NW      
Sbjct: 806  ENEVPAPVKPVTDSTSAPAPKLALR-----ETPAPLAVTSSEP----STTPNNW------ 850

Query: 886  GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHEN-IQ 944
              +    +P S  E  K  T   + +   P     S+ ++   S+  P     +  + + 
Sbjct: 851  -ADFSSTWPTSTNE--KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL 907

Query: 945  GGGEPF-----QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 999
            G GE       QALY +  + ++ L   ++DVI V+E+ D  WF G  +  K  G FP +
Sbjct: 908  GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQK--GWFPKS 964

Query: 1000 YVK 1002
            YVK
Sbjct: 965  YVK 967



 Score = 32.0 bits (71), Expect = 3.0
 Identities = 16/62 (25%), Positives = 31/62 (50%), Gaps = 9/62 (14%)

Query: 950  FQALYNYTPRNEDELELRESDV-------IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
            ++ALY +  R+ DE+ ++  D+       +D  +  + GW  G  +     G FP NY +
Sbjct: 745  YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT--GWFPANYAE 802

Query: 1003 RL 1004
            ++
Sbjct: 803  KI 804


>gi|11321634 CD2-associated protein [Homo sapiens]
          Length = 639

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 53/165 (32%), Positives = 96/165 (58%), Gaps = 12/165 (7%)

Query: 848  IAKYNFNADTNVELSLRKGDRVILLKRV-DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 906
            I +Y+++A  + EL++R G+ +  +K++ ++ W EG++ G  R+G+FP ++V+ +K+ T+
Sbjct: 5    IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRETE 62

Query: 907  GAED-YPDPPIPHSYSSDRIHSLSS-NKPQRPVFTH---ENIQGGGEPFQA--LYNYTPR 959
              +D  P     H   +  +  +S+   P   +  H   +NI+   +  Q   L+ Y P+
Sbjct: 63   FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQ 122

Query: 960  NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            NEDELEL+  D+ID+ E+ ++GW+ GT       G FP N+VK L
Sbjct: 123  NEDELELKVGDIIDINEEVEEGWWSGTLNNK--LGLFPSNFVKEL 165



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 100/325 (30%)

Query: 776  YDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHHGRVGIFPISYVEKL-TPPEKAQPA 833
            YD+ A    EL+ + G+ +  ++K+ ++ W EGE +GR G+FP ++V+++    E    +
Sbjct: 8    YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67

Query: 834  RPPPPAQPGEIGEAIAK--------------------------------YNFNADTNVEL 861
             P    + G +   + +                                + +      EL
Sbjct: 68   LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127

Query: 862  SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG----AED------- 910
             L+ GD + + + V++ W+ G +   N+ G+FP ++V+ ++    G    A+D       
Sbjct: 128  ELKVGDIIDINEEVEEGWWSGTL--NNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLA 185

Query: 911  YPDPPIP---------------------------HSYSSDRIHSLSSN------KPQRPV 937
             P  PIP                               S ++ + +S+      KP++P+
Sbjct: 186  GPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPL 245

Query: 938  -------------FTHENIQG---GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CD 979
                          T  + +G     E  + L+ Y   NEDEL  +E ++I ++ K   +
Sbjct: 246  ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305

Query: 980  DGWFVGTSRRTKFFGTFPGNYVKRL 1004
             GW+ G     +  G FP N+  ++
Sbjct: 306  AGWWRGELNGKE--GVFPDNFAVQI 328



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 5/88 (5%)

Query: 767 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKL 824
           K K   + ++ ++     EL+FK+G+ ++++ K   +  W+ GE +G+ G+FP ++  ++
Sbjct: 269 KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328

Query: 825 TPPEK--AQPARPPPPAQ-PGEIGEAIA 849
              +K   +P +PPPPA+ P    E IA
Sbjct: 329 NELDKDFPKPKKPPPPAKAPAPKPELIA 356


>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
            sapiens]
          Length = 665

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 50/162 (30%), Positives = 90/162 (55%), Gaps = 12/162 (7%)

Query: 846  EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNT 905
            EAI ++++ A  + EL++  G+ +  +++ D  W+EG+I G  R+G+FP ++V  +KK  
Sbjct: 3    EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60

Query: 906  KG---AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 962
            K        P+ P+    S + +  LSS    R   T++  +      Q  ++Y P+N+D
Sbjct: 61   KKDPLTNKAPEKPLHEVPSGNSL--LSSETILR---TNKRGERRRRRCQVAFSYLPQNDD 115

Query: 963  ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            ELEL+  D+I+V+ + ++GW+ G        G FP N++K L
Sbjct: 116  ELELKVGDIIEVVGEVEEGWWEGVLNGKT--GMFPSNFIKEL 155



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)

Query: 767 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 824
           K K   K ++ ++AQ   EL+ K+GD V ++ K  ID  W+EGE +GR G+FP ++V KL
Sbjct: 267 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 325

Query: 825 TPP----EKAQPARPPPPAQP 841
            PP    E  +P +PPPP+ P
Sbjct: 326 LPPDFEKEGNRPKKPPPPSAP 346



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 37/148 (25%), Positives = 73/148 (49%), Gaps = 26/148 (17%)

Query: 776 YDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARP 835
           +D++AQ   EL+   G+ +  +RK D  W+EG+ +GR G+FP ++V ++    K  P   
Sbjct: 8   FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67

Query: 836 PPPAQP-------------------GEIGEAIAK-----YNFNADTNVELSLRKGDRVIL 871
             P +P                    + GE   +     +++    + EL L+ GD + +
Sbjct: 68  KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127

Query: 872 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 899
           +  V++ W+EG + G  + G+FP ++++
Sbjct: 128 VGEVEEGWWEGVLNG--KTGMFPSNFIK 153



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 46/241 (19%), Positives = 104/241 (43%), Gaps = 13/241 (5%)

Query: 766  EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLT 825
            E+ +   +  + +  Q   EL  K GD + ++ ++++ W+EG  +G+ G+FP +++++L+
Sbjct: 97   ERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELS 156

Query: 826  PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 885
                              + E     +   D++   S  +G    +     Q     K+ 
Sbjct: 157  GESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVK 211

Query: 886  GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQG 945
            G     IF    +++  ++ +   D+    +P   +  +    ++  P       ++   
Sbjct: 212  GVGFGDIFKDKPIKLRPRSIEVENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTK 267

Query: 946  GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKR 1003
              +  + ++ Y  +N+DEL ++E D++ ++ K   D GW+ G     +  G FP N+VK 
Sbjct: 268  SKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKL 325

Query: 1004 L 1004
            L
Sbjct: 326  L 326



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)

Query: 851 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 908
           + + A  + EL++++GD V L+ +  +D  W+EG++ G  R+G+FP ++V+++  + +  
Sbjct: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 333

Query: 909 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 960
            + P  P P S         +++R H +    P+RP            P +      P  
Sbjct: 334 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 384

Query: 961 EDELELRESDV 971
           E +L+L++  V
Sbjct: 385 EPKLDLQKPSV 395



 Score = 32.3 bits (72), Expect = 2.3
 Identities = 36/133 (27%), Positives = 59/133 (44%), Gaps = 17/133 (12%)

Query: 62  PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWD--PPDRKVDTRKFRSEPRSIFEY 119
           P+  K+ + P  PP  PP  P ++    ++  KH+    PP+R  +    R+E +   E 
Sbjct: 328 PDFEKEGNRPKKPP--PPSAPVIKQGAGTTERKHEIKKIPPERP-EMLPNRTEEKERPER 384

Query: 120 EPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS 179
           EP K  + +   PA      I     RP  + S++     R  + P   P R +G  + +
Sbjct: 385 EP-KLDLQKPSVPA------IPPKKPRPPKTNSLS-----RPGALPPRRPERPVGPLTHT 432

Query: 180 RTSPGRVDLPGSS 192
           R    ++DL GSS
Sbjct: 433 RGDSPKIDLAGSS 445


>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
          Length = 729

 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 60/185 (32%), Positives = 97/185 (52%), Gaps = 38/185 (20%)

Query: 733 RGGALQDRESPRSYSSTLTD--MGRSAPRERRGTPEK---------EKLP-AKAVYDFKA 780
           RGG+ +     R  + TL D    R+ PR  + +P +         + +P AKA+ +++ 
Sbjct: 84  RGGSFR-----RPGTMTLQDGRKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRG 138

Query: 781 QTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQ 840
           Q   +L F KGD + + R++D+NWY+GE +G  G FP S VE +      Q  +PPP  +
Sbjct: 139 QNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI-----KQLPQPPPLCR 193

Query: 841 PGEIGEAIAKYNFN------ADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFP 894
                   A YNF+      ++    L+  K D + ++ RVD+NW EGK+   ++ GIFP
Sbjct: 194 --------ALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GDKVGIFP 243

Query: 895 VSYVE 899
           + +VE
Sbjct: 244 ILFVE 248



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 47/148 (31%)

Query: 844 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 903
           +  A A  N+      +L   KGD ++L +++D+NWY+G+I G +  G FP S VEV+K+
Sbjct: 127 VPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVEVIKQ 184

Query: 904 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPR---- 959
                   P PP                    P+             +ALYN+  R    
Sbjct: 185 -------LPQPP--------------------PLC------------RALYNFDLRGKDK 205

Query: 960 --NEDELELRESDVIDVMEKCDDGWFVG 985
             N+D L   + D+I V+ + D+ W  G
Sbjct: 206 SENQDCLTFLKDDIITVISRVDENWAEG 233



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 23/52 (44%), Positives = 32/52 (61%)

Query: 950  FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1001
            F AL++Y+    DEL+L++ + + V+ KC DGW  G S  T   G FP NYV
Sbjct: 385  FVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 3/75 (4%)

Query: 848 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 907
           +A ++++A    EL L+KG+ V +L +    W  G    T R GIFP +YV  + + T  
Sbjct: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKT-- 443

Query: 908 AEDYPDPPIPHSYSS 922
              +PD   P  Y++
Sbjct: 444 -SSFPDSRSPGLYTT 457



 Score = 38.1 bits (87), Expect = 0.042
 Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 2/50 (4%)

Query: 774 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH--HGRVGIFPISYV 821
           A++ + A    EL  +KG+ V +L K    W  G     GRVGIFP +YV
Sbjct: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436



 Score = 30.8 bits (68), Expect = 6.7
 Identities = 15/52 (28%), Positives = 26/52 (50%), Gaps = 2/52 (3%)

Query: 951  QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
            +AL NY  +N  +L   + D+I +  + D+ W+ G        G FP + V+
Sbjct: 131  KALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVE 180


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 78/291 (26%), Positives = 121/291 (41%), Gaps = 63/291 (21%)

Query: 768  EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 827
            E L A+A+  + A+    L+F K D + +L +  +NW+ GE HG  G FP SYV K+ P 
Sbjct: 872  ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYV-KIIPG 929

Query: 828  EKAQPARPP---------PPAQPGEIGEA-IAKYNFNADTNVELSLRKGDRVILLKRVDQ 877
             + +   P          P +    +GE  IA Y +++    +L+  +G+ +++ ++ D 
Sbjct: 930  SEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DG 988

Query: 878  NWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDYPDPPIPH---SYSSDRIHSLS 929
             W+ G I   +R GIFP +YV     E     +K       P I     +Y +     LS
Sbjct: 989  EWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLS 1046

Query: 930  SNKPQRPVFTHEN--------IQGGGEPFQ------------------------------ 951
                Q  +   +N        +Q  G+  Q                              
Sbjct: 1047 LAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVI 1106

Query: 952  ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
            A+Y+Y   NEDEL   +  +I+VM K D  W+ G        G FP NYVK
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVK 1155



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 59/218 (27%), Positives = 99/218 (45%), Gaps = 26/218 (11%)

Query: 735  GALQDRES--PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGD 792
            G++ DR    P +Y     D        + G   K+   A+    + A  S++LS   G 
Sbjct: 993  GSIGDRSGIFPSNYVKP-KDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQ 1051

Query: 793  TVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEIGE 846
             + IL+K    W++GE   R      G FP S+V+ L P  E+A PA  P       + +
Sbjct: 1052 LILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------VCQ 1104

Query: 847  AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 906
             IA Y++ A+   ELS  KG  + ++ + D +W++G+I G    G+FP +YV++   +  
Sbjct: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS-- 1160

Query: 907  GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 944
                  DP          + ++   + +R  + HE IQ
Sbjct: 1161 ------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1192



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 34/102 (33%), Positives = 50/102 (49%), Gaps = 7/102 (6%)

Query: 731  QDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PAKAVYDFKAQTSKELSFK 789
            Q RG   Q    P S+   L       P   R TP    +    A+YD+ A    ELSF 
Sbjct: 1069 QARGKKRQKGWFPASHVKLL------GPSSERATPAFHPVCQVIAMYDYAANNEDELSFS 1122

Query: 790  KGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 831
            KG  + ++ K D +W++GE +G  G+FP +YV+  T  + +Q
Sbjct: 1123 KGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1164



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)

Query: 773 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 830
           +A+Y F+A+   E+SF  GD + +  K   +  W  G   G  G FP +YVEK+   E  
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795

Query: 831 QPARPPPPAQP 841
           +   P     P
Sbjct: 796 KAVSPKKALLP 806



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)

Query: 950  FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            ++ALY +  RN DE+     D+I V EK   + GW  G+ +    FG FP NYV+++
Sbjct: 735  YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 789


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 78/291 (26%), Positives = 121/291 (41%), Gaps = 63/291 (21%)

Query: 768  EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 827
            E L A+A+  + A+    L+F K D + +L +  +NW+ GE HG  G FP SYV K+ P 
Sbjct: 899  ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYV-KIIPG 956

Query: 828  EKAQPARPP---------PPAQPGEIGEA-IAKYNFNADTNVELSLRKGDRVILLKRVDQ 877
             + +   P          P +    +GE  IA Y +++    +L+  +G+ +++ ++ D 
Sbjct: 957  SEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DG 1015

Query: 878  NWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDYPDPPIPH---SYSSDRIHSLS 929
             W+ G I   +R GIFP +YV     E     +K       P I     +Y +     LS
Sbjct: 1016 EWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLS 1073

Query: 930  SNKPQRPVFTHEN--------IQGGGEPFQ------------------------------ 951
                Q  +   +N        +Q  G+  Q                              
Sbjct: 1074 LAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVI 1133

Query: 952  ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
            A+Y+Y   NEDEL   +  +I+VM K D  W+ G        G FP NYVK
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVK 1182



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 59/218 (27%), Positives = 99/218 (45%), Gaps = 26/218 (11%)

Query: 735  GALQDRES--PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGD 792
            G++ DR    P +Y     D        + G   K+   A+    + A  S++LS   G 
Sbjct: 1020 GSIGDRSGIFPSNYVKP-KDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQ 1078

Query: 793  TVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEIGE 846
             + IL+K    W++GE   R      G FP S+V+ L P  E+A PA  P       + +
Sbjct: 1079 LILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------VCQ 1131

Query: 847  AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 906
             IA Y++ A+   ELS  KG  + ++ + D +W++G+I G    G+FP +YV++   +  
Sbjct: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS-- 1187

Query: 907  GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 944
                  DP          + ++   + +R  + HE IQ
Sbjct: 1188 ------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1219



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 34/102 (33%), Positives = 50/102 (49%), Gaps = 7/102 (6%)

Query: 731  QDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PAKAVYDFKAQTSKELSFK 789
            Q RG   Q    P S+   L       P   R TP    +    A+YD+ A    ELSF 
Sbjct: 1096 QARGKKRQKGWFPASHVKLL------GPSSERATPAFHPVCQVIAMYDYAANNEDELSFS 1149

Query: 790  KGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 831
            KG  + ++ K D +W++GE +G  G+FP +YV+  T  + +Q
Sbjct: 1150 KGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)

Query: 773 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 830
           +A+Y F+A+   E+SF  GD + +  K   +  W  G   G  G FP +YVEK+   E  
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822

Query: 831 QPARPPPPAQP 841
           +   P     P
Sbjct: 823 KAVSPKKALLP 833



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)

Query: 950  FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 1004
            ++ALY +  RN DE+     D+I V EK   + GW  G+ +    FG FP NYV+++
Sbjct: 762  YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 816


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,610,943
Number of Sequences: 37866
Number of extensions: 2608134
Number of successful extensions: 19069
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 327
Number of HSP's successfully gapped in prelim test: 384
Number of HSP's that attempted gapping in prelim test: 14321
Number of HSP's gapped (non-prelim): 3639
length of query: 1004
length of database: 18,247,518
effective HSP length: 112
effective length of query: 892
effective length of database: 14,006,526
effective search space: 12493821192
effective search space used: 12493821192
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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