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Search of human proteins with 224586851
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
(824 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 1679 0.0
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 1360 0.0
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 1235 0.0
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 1226 0.0
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 978 0.0
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 816 0.0
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 555 e-158
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 555 e-158
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 385 e-106
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 382 e-106
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 379 e-105
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 357 3e-98
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 357 3e-98
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 279 7e-75
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 276 6e-74
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 256 8e-68
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 228 1e-59
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 117 3e-26
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 114 5e-25
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 113 8e-25
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 96 2e-19
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 91 4e-18
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 88 4e-17
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 87 6e-17
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 87 6e-17
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 84 5e-16
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 84 5e-16
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 84 5e-16
gi|11321634 CD2-associated protein [Homo sapiens] 83 9e-16
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 83 1e-15
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 1679 bits (4347), Expect = 0.0
Identities = 824/824 (100%), Positives = 824/824 (100%)
Query: 1 MYSNEDSRQTIVYSEESNTTMSYTQKITNPLPAASSTDPAPFANINTPVLQEDYRQDSQT 60
MYSNEDSRQTIVYSEESNTTMSYTQKITNPLPAASSTDPAPFANINTPVLQEDYRQDSQT
Sbjct: 1 MYSNEDSRQTIVYSEESNTTMSYTQKITNPLPAASSTDPAPFANINTPVLQEDYRQDSQT 60
Query: 61 RRISTLKLTHNQDLGSSSPISTPQFSKSVEVPSFLKRPRSLTPNPVPETHTASLSIQIAP 120
RRISTLKLTHNQDLGSSSPISTPQFSKSVEVPSFLKRPRSLTPNPVPETHTASLSIQIAP
Sbjct: 61 RRISTLKLTHNQDLGSSSPISTPQFSKSVEVPSFLKRPRSLTPNPVPETHTASLSIQIAP 120
Query: 121 LSGQDLESHKQLPELSPETAKIPLQQERQKSAVAAASQSSDCRVSQITVNGNSGGAVSPM 180
LSGQDLESHKQLPELSPETAKIPLQQERQKSAVAAASQSSDCRVSQITVNGNSGGAVSPM
Sbjct: 121 LSGQDLESHKQLPELSPETAKIPLQQERQKSAVAAASQSSDCRVSQITVNGNSGGAVSPM 180
Query: 181 SYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEE 240
SYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEE
Sbjct: 181 SYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEE 240
Query: 241 KRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTP 300
KRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTP
Sbjct: 241 KRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTP 300
Query: 301 YTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLR 360
YTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLR
Sbjct: 301 YTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLR 360
Query: 361 PRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTPTPVPRE 420
PRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTPTPVPRE
Sbjct: 361 PRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTPTPVPRE 420
Query: 421 PGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEA 480
PGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEA
Sbjct: 421 PGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEA 480
Query: 481 SLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSST 540
SLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSST
Sbjct: 481 SLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSST 540
Query: 541 TLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKA 600
TLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKA
Sbjct: 541 TLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKA 600
Query: 601 QTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQ 660
QTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQ
Sbjct: 601 QTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQ 660
Query: 661 PGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 720
PGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV
Sbjct: 661 PGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 720
Query: 721 VKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 780
VKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN
Sbjct: 721 VKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 780
Query: 781 EDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
EDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 781 EDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 1360 bits (3520), Expect = 0.0
Identities = 660/660 (100%), Positives = 660/660 (100%)
Query: 165 SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD 224
SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD
Sbjct: 72 SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD 131
Query: 225 GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 284
GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI
Sbjct: 132 GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 191
Query: 285 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 344
HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS
Sbjct: 192 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 251
Query: 345 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 404
SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH
Sbjct: 252 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 311
Query: 405 ERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKK 464
ERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKK
Sbjct: 312 ERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKK 371
Query: 465 PLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS 524
PLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS
Sbjct: 372 PLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS 431
Query: 525 ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT 584
ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT
Sbjct: 432 ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT 491
Query: 585 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 644
PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL
Sbjct: 492 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 551
Query: 645 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 704
TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI
Sbjct: 552 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 611
Query: 705 PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 764
PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ
Sbjct: 612 PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 671
Query: 765 GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 672 GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 1235 bits (3196), Expect = 0.0
Identities = 612/661 (92%), Positives = 614/661 (92%), Gaps = 27/661 (4%)
Query: 165 SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD 224
SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD
Sbjct: 32 SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD 91
Query: 225 GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 284
GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI
Sbjct: 92 GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 151
Query: 285 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 344
HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS
Sbjct: 152 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 211
Query: 345 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 404
SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH
Sbjct: 212 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 271
Query: 405 ERPPP-LPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPK 463
ERP + + EP K S G PPK
Sbjct: 272 ERPTDRINPDDIDLENEPWYKFFSELEFGR--------------------------PPPK 305
Query: 464 KPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQ 523
KPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQ
Sbjct: 306 KPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQ 365
Query: 524 SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRG 583
SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRG
Sbjct: 366 SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRG 425
Query: 584 TPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK 643
TPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK
Sbjct: 426 TPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK 485
Query: 644 LTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGK 703
LTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGK
Sbjct: 486 LTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGK 545
Query: 704 IPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENI 763
IPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENI
Sbjct: 546 IPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENI 605
Query: 764 QGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKR 823
QGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKR
Sbjct: 606 QGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKR 665
Query: 824 L 824
L
Sbjct: 666 L 666
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 1226 bits (3173), Expect = 0.0
Identities = 607/660 (91%), Positives = 607/660 (91%), Gaps = 53/660 (8%)
Query: 165 SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD 224
SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD
Sbjct: 55 SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD 114
Query: 225 GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 284
GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI
Sbjct: 115 GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 174
Query: 285 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 344
HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS
Sbjct: 175 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 234
Query: 345 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 404
SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH
Sbjct: 235 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 294
Query: 405 ERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKK 464
ERPPP KK
Sbjct: 295 ERPPP-----------------------------------------------------KK 301
Query: 465 PLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS 524
PLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS
Sbjct: 302 PLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS 361
Query: 525 ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT 584
ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT
Sbjct: 362 ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT 421
Query: 585 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 644
PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL
Sbjct: 422 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 481
Query: 645 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 704
TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI
Sbjct: 482 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 541
Query: 705 PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 764
PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ
Sbjct: 542 PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 601
Query: 765 GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 602 GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 978 bits (2527), Expect = 0.0
Identities = 508/660 (76%), Positives = 527/660 (79%), Gaps = 87/660 (13%)
Query: 165 SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD 224
SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD
Sbjct: 72 SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD 131
Query: 225 GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 284
GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI
Sbjct: 132 GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 191
Query: 285 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 344
HMVHKP GLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS
Sbjct: 192 HMVHKP---------------GLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 236
Query: 345 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 404
SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH
Sbjct: 237 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 296
Query: 405 ERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKK 464
ERP L + E +P+SS+ + S PA+ P R
Sbjct: 297 ERPASLYQSSIDRSLE---RPMSSASMA-----------SDFRKRRKSEPAVGPPRG--- 339
Query: 465 PLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS 524
+ S ++S R ++ P SS ++ F S P+ ++
Sbjct: 340 ------------LGDQSASRTSPGR-VDLPGSSTTLTKSFTSSSPSSPS---------RA 377
Query: 525 ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT 584
R SP +S++S TLTDMGRSAPRERRGT
Sbjct: 378 KDRESP-------------RSYSS--------------------TLTDMGRSAPRERRGT 404
Query: 585 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 644
PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL
Sbjct: 405 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 464
Query: 645 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 704
TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI
Sbjct: 465 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 524
Query: 705 PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 764
PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ
Sbjct: 525 PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 584
Query: 765 GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 585 GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 816 bits (2107), Expect = 0.0
Identities = 419/556 (75%), Positives = 438/556 (78%), Gaps = 72/556 (12%)
Query: 269 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 328
TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 9 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 68
Query: 329 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 388
SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 69 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 128
Query: 389 RSIFEYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPT 448
RSIFEYEPGKSSILQHERP L + E +P+SS+ + S
Sbjct: 129 RSIFEYEPGKSSILQHERPASLYQSSIDRSLE---RPMSSASMA-----------SDFRK 174
Query: 449 PSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR 508
PA+ P R + S ++S R ++ P SS ++ F
Sbjct: 175 RRKSEPAVGPPRG---------------LGDQSASRTSPGR-VDLPGSSTTLTKSFTSSS 218
Query: 509 KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSS 568
S P+ ++ R SP +S++S
Sbjct: 219 PSSPS---------RAKDRESP-------------RSYSS-------------------- 236
Query: 569 TLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE 628
TLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE
Sbjct: 237 TLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE 296
Query: 629 HHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR 688
HHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR
Sbjct: 297 HHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR 356
Query: 689 VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL 748
VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL
Sbjct: 357 VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL 416
Query: 749 SSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSR 808
SSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSR
Sbjct: 417 SSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSR 476
Query: 809 RTKFFGTFPGNYVKRL 824
RTKFFGTFPGNYVKRL
Sbjct: 477 RTKFFGTFPGNYVKRL 492
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 555 bits (1429), Expect = e-158
Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)
Query: 502 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 557
S R R+S P P L A P + D +P S++ +SS R
Sbjct: 677 SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 735
Query: 558 --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 615
+DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 736 ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 795
Query: 616 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 675
ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 796 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 855
Query: 676 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 735
DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 856 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 915
Query: 736 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 795
IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 916 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 975
Query: 796 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 976 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 263 bits (671), Expect = 6e-70
Identities = 132/179 (73%), Positives = 136/179 (75%), Gaps = 17/179 (9%)
Query: 269 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 328
TVDRPKDWYKTMFKQIHMVHKP GLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 9 TVDRPKDWYKTMFKQIHMVHKP---------------GLYNPPYSAQSHPAAKTQTYRPL 53
Query: 329 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 388
SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 54 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 113
Query: 389 RSIFEYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAP 447
RSIFEYEPGKSSILQHERP L + + R R S+S + P G P
Sbjct: 114 RSIFEYEPGKSSILQHERPASL--YQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPP 170
Score = 167 bits (424), Expect = 3e-41
Identities = 115/234 (49%), Positives = 129/234 (55%), Gaps = 37/234 (15%)
Query: 408 PPLPTTPTPVPREPGRKPLSSSRLGEV------TGSPSPPPRSGAPTPSSRAPALSPTR- 460
PP P + +PLS S SP PPP P P R S T
Sbjct: 35 PPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEK 94
Query: 461 ----PPKKPLD-------------YVQDHSSGVFNE--ASLYQSSIDRSLERPMSSASMA 501
PP + +D Y SS + +E ASLYQSSIDRSLERPMSSASMA
Sbjct: 95 HDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMA 154
Query: 502 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRE 561
SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK +
Sbjct: 155 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGD 214
Query: 562 SPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVY----DFKAQTSKELSFKKG 611
+ S + G + G P E L + Y D + + +SFK G
Sbjct: 215 DSKICPSLCSYSGLN------GNPSSE-LDYCSTYRQHLDVPRDSPRAISFKNG 261
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 555 bits (1429), Expect = e-158
Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)
Query: 502 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 557
S R R+S P P L A P + D +P S++ +SS R
Sbjct: 773 SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 831
Query: 558 --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 615
+DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 832 ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 891
Query: 616 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 675
ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 892 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 951
Query: 676 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 735
DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 952 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 1011
Query: 736 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 795
IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 1012 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 1071
Query: 796 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 1072 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 483 bits (1244), Expect = e-136
Identities = 236/268 (88%), Positives = 240/268 (89%), Gaps = 2/268 (0%)
Query: 180 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 239
MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE
Sbjct: 1 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 60
Query: 240 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 299
EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT
Sbjct: 61 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 120
Query: 300 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 359
PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL
Sbjct: 121 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 180
Query: 360 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTPTPVPR 419
RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP L + + R
Sbjct: 181 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASL--YQSSIDR 238
Query: 420 EPGRKPLSSSRLGEVTGSPSPPPRSGAP 447
R S+S + P G P
Sbjct: 239 SLERPMSSASMASDFRKRRKSEPAVGPP 266
Score = 167 bits (424), Expect = 3e-41
Identities = 115/234 (49%), Positives = 129/234 (55%), Gaps = 37/234 (15%)
Query: 408 PPLPTTPTPVPREPGRKPLSSSRLGEV------TGSPSPPPRSGAPTPSSRAPALSPTR- 460
PP P + +PLS S SP PPP P P R S T
Sbjct: 131 PPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEK 190
Query: 461 ----PPKKPLD-------------YVQDHSSGVFNE--ASLYQSSIDRSLERPMSSASMA 501
PP + +D Y SS + +E ASLYQSSIDRSLERPMSSASMA
Sbjct: 191 HDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMA 250
Query: 502 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRE 561
SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK +
Sbjct: 251 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGD 310
Query: 562 SPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVY----DFKAQTSKELSFKKG 611
+ S + G + G P E L + Y D + + +SFK G
Sbjct: 311 DSKICPSLCSYSGLN------GNPSSE-LDYCSTYRQHLDVPRDSPRAISFKNG 357
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 385 bits (988), Expect = e-106
Identities = 279/783 (35%), Positives = 401/783 (51%), Gaps = 121/783 (15%)
Query: 76 SSSPISTPQFSKSVEVPSFLKRPRSLTPNPVPETHTASLSIQIAPLSGQDLES-HKQLPE 134
SSSP S + + P P S + + A+ + Q + L+ + S H LP
Sbjct: 84 SSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPS 143
Query: 135 LSPETAKIPLQQERQKSAVAAASQSSDCRVSQITVNGNSGGAVSPMSYYQRPFSPSAYSL 194
+ + PL E S + SQ+ VS+ + S V+P + L
Sbjct: 144 DKSQDSS-PLLNEVSSSLIGTDSQAFPS-VSKPSSAYPSTTIVNPTIVLLQHNREQQKRL 201
Query: 195 PASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGI 254
+SL+ + + DS T + TS + + ++++ R V+K+
Sbjct: 202 -SSLSDPVSERRVGEQDSAPTQEK-------PTSPGKAIEKRAKDDSR-RVVKSTQDLSD 252
Query: 255 GPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSA 314
+DE GIP +R T +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P
Sbjct: 253 VSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP---- 304
Query: 315 QSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDP 374
S P +K++ S+ D + A+ P+P +SS+E++DW+P
Sbjct: 305 LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEP 349
Query: 375 PDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEV 434
PD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ +
Sbjct: 350 PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEK---------------------------M 382
Query: 435 TGSPSPPPRSGAPTP----SSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSID-- 488
+ + SP P + TP SS A+ K+ D + + NE +Y+S ++
Sbjct: 383 SSAISPTPEISSETPGYIYSSNFHAV------KRESDGAPGDLTSLENERQIYKSVLEGG 436
Query: 489 -------RSLERPMSSASM-----------------ASDFRKRRKSEPAVGPPRGLGDQS 524
L+RP SSAS +F +RR + + L DQ
Sbjct: 437 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKE----KLLADQR 492
Query: 525 ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT 584
+ D+ + T P+ + L ++ +A R+
Sbjct: 493 RLKREQEEADIAA------RRHTGVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS- 540
Query: 585 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 644
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L
Sbjct: 541 ---EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 597
Query: 645 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 704
P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+I
Sbjct: 598 PPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRI 656
Query: 705 PGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENI 763
PGT+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T +
Sbjct: 657 PGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRS 716
Query: 764 QGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 821
Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYV
Sbjct: 717 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 776
Query: 822 KRL 824
K L
Sbjct: 777 KPL 779
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 382 bits (981), Expect = e-106
Identities = 246/623 (39%), Positives = 344/623 (55%), Gaps = 111/623 (17%)
Query: 235 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 294
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 194 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 247
Query: 295 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 354
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 248 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 297
Query: 355 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTP 414
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 298 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEK-------- 340
Query: 415 TPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTP----SSRAPALSPTRPPKKPLDYVQ 470
++ + SP P + TP SS A+ K+ D
Sbjct: 341 -------------------MSSAISPTPEISSETPGYIYSSNFHAV------KRESDGAP 375
Query: 471 DHSSGVFNEASLYQSSID---------RSLERPMSSASM-----------------ASDF 504
+ + NE +Y+S ++ L+RP SSAS +F
Sbjct: 376 GDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEF 435
Query: 505 RKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR 564
+RR + + L DQ + D+ + T P+ +
Sbjct: 436 IRRRHDDKE----KLLADQRRLKREQEEADIAA------RRHTGVIPTHHQFITNERF-- 483
Query: 565 SYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNW 624
L ++ +A R+ E PA+A +DFKAQT KEL +KGD VYI ++IDQNW
Sbjct: 484 ---GDLLNIDDTAKRKSGS----EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNW 536
Query: 625 YEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLR 684
YEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S R
Sbjct: 537 YEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFR 595
Query: 685 KGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSD 743
KG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 596 KGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRS 655
Query: 744 RIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDG 801
S + Q+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDG
Sbjct: 656 ATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDG 715
Query: 802 WFVGTSRRTKFFGTFPGNYVKRL 824
WFVGTSRRTK FGTFPGNYVK L
Sbjct: 716 WFVGTSRRTKQFGTFPGNYVKPL 738
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 379 bits (972), Expect = e-105
Identities = 254/666 (38%), Positives = 355/666 (53%), Gaps = 127/666 (19%)
Query: 235 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 294
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 289 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 342
Query: 295 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 354
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 343 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 392
Query: 355 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPP-PLPTT 413
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ +
Sbjct: 393 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPE 443
Query: 414 PTPVPREPGRKPLSSSRLGEVTGSPSPPPR----------SGAPTPSSRAPALSPT---- 459
+ EP K S G+ PPP+ S P ++ A+SPT
Sbjct: 444 EIDLKNEPWYKFFSELEFGK------PPPKKIWDYTPGDCSILPREDRKSSAISPTPEIS 497
Query: 460 ------------RPPKKPLDYVQDHSSGVFNEASLYQSSID---------RSLERPMSSA 498
K+ D + + NE +Y+S ++ L+RP SSA
Sbjct: 498 SETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSA 557
Query: 499 SM-----------------ASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTT 541
S +F +RR + + L DQ + D+
Sbjct: 558 STKDSESPRHFIPADYLESTEEFIRRRHDDKE----KLLADQRRLKREQEEADIAA---- 609
Query: 542 LTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQ 601
+ T P+ + L ++ +A R+ E PA+A +DFKAQ
Sbjct: 610 --RRHTGVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS----EMRPARAKFDFKAQ 658
Query: 602 TSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQP 661
T KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q
Sbjct: 659 TLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQV 717
Query: 662 GEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 721
E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+
Sbjct: 718 LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 777
Query: 722 KKN-TKGAEDYPDPPIPHSYSSDRI-------HSLSSN-------------KPQRPVFTH 760
K+ K DY D P S S HSL + + Q+ T
Sbjct: 778 KRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTP 837
Query: 761 ENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPG 818
+ Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPG
Sbjct: 838 DRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPG 897
Query: 819 NYVKRL 824
NYVK L
Sbjct: 898 NYVKPL 903
Score = 33.5 bits (75), Expect = 0.83
Identities = 108/582 (18%), Positives = 199/582 (34%), Gaps = 106/582 (18%)
Query: 316 SHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPP 375
S PA + ++ P+S++ SP PPP+ P P D + D
Sbjct: 153 SQPARASGSFAPISQTPPSFSP---------------PPPLVPPAPEDLRRVSEPDLTGA 197
Query: 376 DRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTT----PTPVPREPGRK------- 424
D+ +E S ++ + P+T PT V + R+
Sbjct: 198 VSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSS 257
Query: 425 ---PLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEAS 481
P+S R+GE +P+ PT +A ++ + QD S +E
Sbjct: 258 LSDPVSERRVGEQDSAPT----QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVG 313
Query: 482 LYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTT 541
+ + +RS + + R + + PR S S + + +P S +
Sbjct: 314 IPLRNTERS--KDWYKTMFKQIHKLNRDDDSDLYSPR----YSFSEDTKSPLSVPRSKSE 367
Query: 542 LT----KSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYD 597
++ + S + P A R S SS D P +++ K + K++Y+
Sbjct: 368 MSYIDGEKVVKRSATLPLPA--RSSSLKSSSERNDW---EPPDKKVDTRKYRAEPKSIYE 422
Query: 598 FKAQTSKELSFKKGDTVYILRKID---QNWYEGEHHGRVGIFPISYVEKLTP-------- 646
++ S L+ +K +ID + WY+ G P + TP
Sbjct: 423 YQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPR 482
Query: 647 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVIL--LKRVDQNWYE-GK 703
++ A P P E I NF+A E GD L +++ ++ E G
Sbjct: 483 EDRKSSAISPTPEISSETPGYIYSSNFHA-VKRESDGAPGDLTSLENERQIYKSVLEGGD 541
Query: 704 IPGTNRQGI------------------FPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRI 745
IP G+ P Y+E ++ + D + + R
Sbjct: 542 IPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKRE 601
Query: 746 H---SLSSNKPQRPVFTHENI------------------QGGGE--PFQALYNYTPRNED 782
+++ + + TH + G E P +A +++ +
Sbjct: 602 QEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLK 661
Query: 783 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
EL L++ D++ + ++ D W+ G G FP Y++ L
Sbjct: 662 ELPLQKGDIVYIYKQIDQNWYEGEHHGR--VGIFPRTYIELL 701
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 357 bits (915), Expect = 3e-98
Identities = 235/598 (39%), Positives = 324/598 (54%), Gaps = 117/598 (19%)
Query: 235 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 294
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 326 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 379
Query: 295 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 354
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 380 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 429
Query: 355 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTP 414
+SS+E++DW+PPD+KVDTR +Y SI +++
Sbjct: 430 ---------KSSSERNDWEPPDKKVDTR----------KYRAEPKSIYEYQ--------- 461
Query: 415 TPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTP----SSRAPALSPTRPPKKPLDYVQ 470
PG+ + ++ +++ + SP P + TP SS A+ K+ D
Sbjct: 462 ------PGKSSVLTNE--KMSSAISPTPEISSETPGYIYSSNFHAV------KRESDGAP 507
Query: 471 DHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSP 530
+ + NE +Y+S ++
Sbjct: 508 GDLTSLENERQIYKSVLEG----------------------------------------- 526
Query: 531 GRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEK 589
G + L G S PSS + KD ESPR + D S RR +KE
Sbjct: 527 GDIPLQGLSGL-------KRPSSSASTKDSESPRHFIPA--DYLESTEEFIRRRHDDKEM 577
Query: 590 LPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEK 649
PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EK
Sbjct: 578 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEK 637
Query: 650 AQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNR 709
AQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+R
Sbjct: 638 AQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSR 696
Query: 710 QGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 768
QGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q +
Sbjct: 697 QGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQD 756
Query: 769 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 757 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 357 bits (915), Expect = 3e-98
Identities = 235/598 (39%), Positives = 324/598 (54%), Gaps = 117/598 (19%)
Query: 235 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 294
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 194 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 247
Query: 295 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 354
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 248 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 297
Query: 355 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTP 414
+SS+E++DW+PPD+KVDTR +Y SI +++
Sbjct: 298 ---------KSSSERNDWEPPDKKVDTR----------KYRAEPKSIYEYQ--------- 329
Query: 415 TPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTP----SSRAPALSPTRPPKKPLDYVQ 470
PG+ + ++ +++ + SP P + TP SS A+ K+ D
Sbjct: 330 ------PGKSSVLTNE--KMSSAISPTPEISSETPGYIYSSNFHAV------KRESDGAP 375
Query: 471 DHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSP 530
+ + NE +Y+S ++
Sbjct: 376 GDLTSLENERQIYKSVLEG----------------------------------------- 394
Query: 531 GRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEK 589
G + L G S PSS + KD ESPR + D S RR +KE
Sbjct: 395 GDIPLQGLSGL-------KRPSSSASTKDSESPRHFIPA--DYLESTEEFIRRRHDDKEM 445
Query: 590 LPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEK 649
PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EK
Sbjct: 446 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEK 505
Query: 650 AQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNR 709
AQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+R
Sbjct: 506 AQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSR 564
Query: 710 QGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 768
QGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q +
Sbjct: 565 QGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQD 624
Query: 769 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 625 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 279 bits (714), Expect = 7e-75
Identities = 210/615 (34%), Positives = 298/615 (48%), Gaps = 133/615 (21%)
Query: 235 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 294
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ +
Sbjct: 358 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEE 412
Query: 295 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY---RPLSKSHSDNSP------NAFKDASS 345
+ Y Y + S + +P T + P KS D+S + +D S
Sbjct: 413 NPYFPTYKFPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKS 472
Query: 346 PVPPPHVPP-----------------PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 388
P+ P P+P +SS+E++DW+PPD+KVDTRK+R+EP
Sbjct: 473 PLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEP 532
Query: 389 RSIFEYEPGKSSILQHER----------------------------PPP------LPTTP 414
+SI+EY+PGKSS+L +E+ PPP P
Sbjct: 533 KSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDC 592
Query: 415 TPVPREPGRKPLSSS-------------RLGEVTGSPSPP-PRSGA--PTP--SSRAPAL 456
+ +PRE + L ++ + +PS P+S A PTP SS P
Sbjct: 593 SILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGY 652
Query: 457 ---SPTRPPKKPLDYVQDHSSGVFNEASLYQSSID---------RSLERPMSSASM---- 500
S K+ D + + NE +Y+S ++ L+RP SSAS
Sbjct: 653 IYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSE 712
Query: 501 -------------ASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFT 547
+F +RR + + L DQ + D+ + T
Sbjct: 713 SPRHFIPADYLESTEEFIRRRHDDKE----KLLADQRRLKREQEEADIAA------RRHT 762
Query: 548 SSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELS 607
P+ + L ++ +A R+ E PA+A +DFKAQT KEL
Sbjct: 763 GVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS----EMRPARAKFDFKAQTLKELP 813
Query: 608 FKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEA 667
+KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEA
Sbjct: 814 LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEA 872
Query: 668 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TK 726
IAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K
Sbjct: 873 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 932
Query: 727 GAEDYPDPPIPHSYS 741
DY D P S S
Sbjct: 933 NPVDYMDLPFSSSPS 947
Score = 102 bits (254), Expect = 1e-21
Identities = 44/55 (80%), Positives = 51/55 (92%)
Query: 770 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
+QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 53.1 bits (126), Expect = 1e-06
Identities = 74/296 (25%), Positives = 111/296 (37%), Gaps = 48/296 (16%)
Query: 396 PGKSSILQHERPPPLPTTPT----PVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSS 451
PG+ S+ PPLP + P P S L ++ S P PRS A +
Sbjct: 996 PGRRSLALTPPLPPLPEASIYNTDHLALSPRASPSLSLSLPHLSWSDRPTPRSVASPLAL 1055
Query: 452 RAP----ALSPTRPPKKPLDY---VQDHSSGVFNEASLY-----QSSIDRSLERPMSSAS 499
+P +L+PT ++ V SSG+ ++ L S+ L SS S
Sbjct: 1056 PSPHKTYSLAPTSQASLHMNGDGGVHTPSSGIHQDSFLQLPLGSSDSVISQLSDAFSSQS 1115
Query: 500 MASDFRKR-----RKSEPAVGPPRGLGDQSASRTS---PGRVDLPGSSTTLTKSFTSSSP 551
+R+ RK+E G RG G S+ S P V S+ +
Sbjct: 1116 KRQPWREESGQYERKAERGAGE-RGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEE 1174
Query: 552 SSPSRAKDRESPRSYSSTLT------DMGRSAPR----------ERRGTPEKEKLPA--- 592
S P + P S + GR A R +RR TP++ +
Sbjct: 1175 SRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLF 1234
Query: 593 --KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 644
+A+Y + Q EL + GD V ++ K D W+ G + G FP +YV+ L
Sbjct: 1235 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 31.2 bits (69), Expect = 4.1
Identities = 105/545 (19%), Positives = 189/545 (34%), Gaps = 116/545 (21%)
Query: 69 THNQDLGSSSPISTPQFS-------KSVEVPSFLKRPRSLTPNPVPETHTASLSIQIAPL 121
++ QD ++ P+ S K+V+ S L P + P + T +++++ +
Sbjct: 20 SNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMDPTKIC-TGKGAVTLRAS-- 76
Query: 122 SGQDLESHKQLPELSPETAKIPLQQERQKSAVAAASQSSDCRVSQITVNGNSGGAVSPMS 181
S+++ P SP + + Q E + S + + R+S + ++ G P S
Sbjct: 77 -----SSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSS---SADANGNAQPSS 128
Query: 182 YYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSS-------IPLY 234
+ + +LP+ +S D T+SS+ +PLY
Sbjct: 129 LAAKGYRSVHPNLPSD-----------------------KSQDATSSSAAQPEVIVVPLY 165
Query: 235 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 294
+ + + + P +GP+ +PT T + T+
Sbjct: 166 LVNTDRGQEGTARPP--TPLGPL--GCVPTIPATASAASPLTFPTL-------------- 207
Query: 295 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 354
D + P+ L P+ +Q PA + ++ P+S++ SP PP
Sbjct: 208 DDFIPPH-----LQRWPHHSQ--PARASGSFAPISQTPPSFSP---------------PP 245
Query: 355 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTT- 413
P+ P P D + D D+ +E S ++ + P+T
Sbjct: 246 PLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTT 305
Query: 414 ---PTPVPREPGRK----------PLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTR 460
PT V + R+ P+S R+GE +P+ PT +A
Sbjct: 306 IVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPT----QEKPTSPGKAIEKRAKD 361
Query: 461 PPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGP--PR 518
++ + QD S +E + + +RS + +M K + P P P
Sbjct: 362 DSRRVVKSTQDLSDVSMDEVGIPLRNTERSKD---WYKTMFKQIHKLNRDTPEENPYFPT 418
Query: 519 GLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRE--SPRSYSSTLTDMGRS 576
+ D P T T F +S+PS S D + SPR S T S
Sbjct: 419 YKFPELPEIQQTSEEDNP---YTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLS 475
Query: 577 APRER 581
PR +
Sbjct: 476 VPRSK 480
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 276 bits (706), Expect = 6e-74
Identities = 211/661 (31%), Positives = 292/661 (44%), Gaps = 147/661 (22%)
Query: 218 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY 277
QH Q+ T + S +KR Y GIGPVDESG+P A R++VDRP+DWY
Sbjct: 98 QHTQNWSATWTKD-----SKRRDKRWV-----KYEGIGPVDESGMPIAPRSSVDRPRDWY 147
Query: 278 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPY-SAQSHPAAKTQTYRPLSKSHSDNS 336
+ MF+QIH PD D +T+ +P + AQ PA
Sbjct: 148 RRMFQQIHR-KMPDLQLD-----WTFEEPPRDPRHLGAQQRPAH---------------- 185
Query: 337 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEP 396
RP +S+ WD + PRS F Y P
Sbjct: 186 -----------------------RPGPATSSSGRSWDHSEEL---------PRSTFNYRP 213
Query: 397 GK-SSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPA 455
G S++LQ P+ RE + + R P
Sbjct: 214 GAFSTVLQ-------PSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDD---- 262
Query: 456 LSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVG 515
P P +P++ + + E S R++E + S + R+ + P G
Sbjct: 263 --PGEKPSQPIEVLLERELA---ELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAG 317
Query: 516 PPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGR 575
P SA +S GS+ +L+ + S +D P S G
Sbjct: 318 PA------SAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGG 371
Query: 576 SAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGI 635
+P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+NW EGEHHGR+GI
Sbjct: 372 GSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGI 428
Query: 636 FPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRV 695
FP +YVE L E +P + PP Q E GEA+A+Y F D VELS RKG+ + L+++V
Sbjct: 429 FPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKV 487
Query: 696 DQNWYEGKIPGTNRQGIFPVSYVEVVK-----------------KNTKGAEDYPDPPIPH 738
++NWYEG+I GT RQGIFP SYV+V + + T A P P
Sbjct: 488 NENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS 547
Query: 739 SYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG-------------------- 767
+ S D I P+R F+ +N+ G
Sbjct: 548 ALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSP 607
Query: 768 -------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNY 820
P++A+Y Y P+NEDELELRE D +DVM++CDDGWFVG SRRT+ FGTFPGNY
Sbjct: 608 NTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNY 667
Query: 821 V 821
V
Sbjct: 668 V 668
Score = 69.7 bits (169), Expect = 1e-11
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 640 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 699
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 358 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 417
Query: 700 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 759
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 418 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 452
Query: 760 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 819
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 453 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 508
Query: 820 YVK 822
YV+
Sbjct: 509 YVQ 511
Score = 42.4 bits (98), Expect = 0.002
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 669 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 721
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 256 bits (653), Expect = 8e-68
Identities = 189/560 (33%), Positives = 273/560 (48%), Gaps = 121/560 (21%)
Query: 291 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 350
DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 476 DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPAR 525
Query: 351 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER---- 406
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 526 SSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRD 576
Query: 407 ------------------------PPP------LPTTPTPVPREPGRKPLSSS------- 429
PPP P + +PRE + L
Sbjct: 577 ISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTE 636
Query: 430 ------RLGEVTGSPSPP-PRSGA--PTP--SSRAPAL---SPTRPPKKPLDYVQDHSSG 475
++ + +PS P+S A PTP SS P S K+ D +
Sbjct: 637 LEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTS 696
Query: 476 VFNEASLYQSSID---------RSLERPMSSASM-----------------ASDFRKRRK 509
+ NE +Y+S ++ L+RP SSAS +F +RR
Sbjct: 697 LENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRH 756
Query: 510 SEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSST 569
+ + L DQ + D+ + T P+ +
Sbjct: 757 DDKE----KLLADQRRLKREQEEADIAA------RRHTGVIPTHHQFITNERF-----GD 801
Query: 570 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 629
L ++ +A R+ E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEH
Sbjct: 802 LLNIDDTAKRKSGS----EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH 857
Query: 630 HGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRV 689
HGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+
Sbjct: 858 HGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERI 916
Query: 690 ILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSL 748
LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S S
Sbjct: 917 TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASP 976
Query: 749 SSNKPQRPVFTHENIQGGGE 768
+ + + + +G GE
Sbjct: 977 QPWREESGQYERKAERGAGE 996
Score = 154 bits (389), Expect = 3e-37
Identities = 174/666 (26%), Positives = 269/666 (40%), Gaps = 157/666 (23%)
Query: 235 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 294
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ +
Sbjct: 358 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEE 412
Query: 295 DMYNTPY--------------TYNAGLYNPPYSA--------------QSHPAAKTQTYR 326
+ Y Y T + + +P S+P
Sbjct: 413 NPYFPTYKFPELPEIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVA 472
Query: 327 PLSKSHSD-NSP--NAFKDASSPVPPPH-----------------VPPPVPPLRPRDRSS 366
+ SD SP + +D SP+ P P+P +SS
Sbjct: 473 GTADDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS 532
Query: 367 TEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER-PPPLPTTPTPVPREPGRKP 425
+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ + + EP K
Sbjct: 533 SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKF 592
Query: 426 LSSSRLGEVTGSPSPPPR---SGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASL 482
S G+ PPP+ P S P +D + + + SL
Sbjct: 593 FSELEFGK------PPPKKIWDYTPGDCSILPR--------------EDRKTNLDKDLSL 632
Query: 483 YQSSIDRSLER------------PMSSA--------------SMASDFRK-RRKSEPAVG 515
Q+ ++ LE+ P SSA +S+F +R+S+ A G
Sbjct: 633 CQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPG 692
Query: 516 PPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGR 575
L ++ S L G L PSS + KD ESPR + +
Sbjct: 693 DLTSLENERQIYKSV----LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA-DYLES 747
Query: 576 SAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGI 635
+ RR +KEKL A + Q +++ ++ V + E G +
Sbjct: 748 TEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVI---PTHHQFITNERFG--DL 802
Query: 636 FPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRV 695
I K + +PAR AK++F A T EL L+KGD V + K++
Sbjct: 803 LNIDDTAKRKSGSEMRPAR--------------AKFDFKAQTLKELPLQKGDIVYIYKQI 848
Query: 696 DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQR 755
DQNWYEG+ G R GIFP +Y+E++ PP + K Q
Sbjct: 849 DQNWYEGEHHG--RVGIFPRTYIELL------------PP--------------AEKAQP 880
Query: 756 PVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGT 815
T + GE A +N+ + E+ R+ + I ++ + D+ W+ G T G
Sbjct: 881 KKLTPVQVLEYGEAI-AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGI 939
Query: 816 FPGNYV 821
FP YV
Sbjct: 940 FPITYV 945
Score = 148 bits (373), Expect = 2e-35
Identities = 105/298 (35%), Positives = 146/298 (48%), Gaps = 49/298 (16%)
Query: 563 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 622
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 865 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 924
Query: 623 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPP------ 657
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 925 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
Query: 658 ---------PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 708
+ G G I+K + ++V L R+ D N E PG
Sbjct: 985 QYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLS-----DLNTPEESRPGKP 1039
Query: 709 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 768
FP S E +++ G + ++ R S QR V T + Q +
Sbjct: 1040 LGSAFPGSEAEQTERHRGGEQ-------AGRKAARRGGSQQPQAQQRRV-TPDRSQTSQD 1091
Query: 769 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1092 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 228 bits (582), Expect = 1e-59
Identities = 131/319 (41%), Positives = 175/319 (54%), Gaps = 59/319 (18%)
Query: 558 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 617
+D P S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI
Sbjct: 12 RDFVYPSSTRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIH 68
Query: 618 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADT 677
+++D+NW EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D
Sbjct: 69 KEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDL 127
Query: 678 NVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK--------------- 722
VELS RKG+ + L+++V++NWYEG+I GT RQGIFP SYV+V +
Sbjct: 128 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPT 187
Query: 723 --KNTKGAEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG-- 767
+ T A P P + S D I P+R F+ +N+ G
Sbjct: 188 SPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPA 247
Query: 768 -------------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGW 802
P++A+Y Y P+NEDELELRE D +DVM++CDDGW
Sbjct: 248 LSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGW 307
Query: 803 FVGTSRRTKFFGTFPGNYV 821
FVG SRRT+ FGTFPGNYV
Sbjct: 308 FVGVSRRTQKFGTFPGNYV 326
Score = 69.7 bits (169), Expect = 1e-11
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 640 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 699
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 16 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 75
Query: 700 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 759
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 76 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 110
Query: 760 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 819
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 111 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 166
Query: 820 YVK 822
YV+
Sbjct: 167 YVQ 169
Score = 45.4 bits (106), Expect = 2e-04
Identities = 33/126 (26%), Positives = 60/126 (47%), Gaps = 12/126 (9%)
Query: 524 SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR---SYS---STLTDMGRSA 577
SA R+ +DL G ++ F+ + + ++ +P S+S S D+G S+
Sbjct: 205 SALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSS 264
Query: 578 PRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGI 635
P T + P +A+Y ++ Q EL ++GD V ++++ D W+ G + G
Sbjct: 265 PN----TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGT 320
Query: 636 FPISYV 641
FP +YV
Sbjct: 321 FPGNYV 326
Score = 42.4 bits (98), Expect = 0.002
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 669 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 721
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 117 bits (294), Expect = 3e-26
Identities = 115/477 (24%), Positives = 196/477 (41%), Gaps = 73/477 (15%)
Query: 395 EPGKSSILQHERPPPLP----------TTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR- 443
+PGK + PPPLP T + + L S+ G+ G PPR
Sbjct: 264 KPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRL 323
Query: 444 -----SGAPTPSSRAPA-LSPTRPPKKPLDYVQDHSSGV-FNEASLYQSSIDRSLERPMS 496
+G P+ + P + P RPP L + + + FN +SS D L++ S
Sbjct: 324 PPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQS 378
Query: 497 SASMASDFRKRR--KSEPAVGPPR-----------------GLGDQSASRTSPGRVDLPG 537
+ + K + K++ V PPR G+ ++ +PG +
Sbjct: 379 NLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKR 438
Query: 538 SSTTLTKSFTSSSPSSPSRAKDRESPR-SYSSTLTDMGRSAPRERRGTPEKEKLP----- 591
+ T ++ + +D S +T + R R P + P
Sbjct: 439 GDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL-RSRPNDPSHAQKPVDSGA 497
Query: 592 --AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PE 648
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 498 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 557
Query: 649 KAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 708
R + + +A++ + + ELS +G+ +IL + V++ W G++ G
Sbjct: 558 GGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG-- 615
Query: 709 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 768
R GIFP+++VE V EDYP S + S + + N Q
Sbjct: 616 RTGIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSL 661
Query: 769 P---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822
P +AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 662 PAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 716
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 590 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 646
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
Query: 647 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 706
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 721 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 774
Query: 707 TNRQGIFPVSYVEVVK 722
+ GIFP +Y++ ++
Sbjct: 775 --KSGIFPKNYIQFLQ 788
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 114 bits (284), Expect = 5e-25
Identities = 116/456 (25%), Positives = 192/456 (42%), Gaps = 54/456 (11%)
Query: 395 EPGKSSILQHERPPPLP----------TTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR- 443
+PGK + PPPLP T + + L S+ G+ G PPR
Sbjct: 264 KPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRL 323
Query: 444 -----SGAPTPSSRAPA-LSPTRPPKKPLDYVQDHSSGV-FNEASLYQSSIDRSLERPMS 496
+G P+ + P + P RPP L + + + FN +SS D L++ S
Sbjct: 324 PPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQS 378
Query: 497 SASMASDFRKRR--KSEPAVGPPRGL-GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSS 553
+ + K + K++ V PPR G S+ G V + T++
Sbjct: 379 NLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLV---MLKQTENNYLECQKG 435
Query: 554 PSRAKDRESPRSYSSTLTDMGRSAPRE--RRGTPEKEKLP-AKAVYDFKAQTSKELSFKK 610
+ S + L + RS P + P P A ++DF A+ +L+
Sbjct: 436 EDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTS 495
Query: 611 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIA 669
G+ VY+L KID +WY G ++GIFP +YV+ + PE R + + +A
Sbjct: 496 GEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVA 555
Query: 670 KYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAE 729
++ + + ELS +G+ +IL + V++ W G++ G R GIFP+++VE V E
Sbjct: 556 RFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPLNFVEPV-------E 606
Query: 730 DYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDELEL 786
DYP S + S + + N Q P +AL+++T D+L
Sbjct: 607 DYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSF 659
Query: 787 RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822
+ D I ++E+ D W G + + G FP +V+
Sbjct: 660 KRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 693
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 590 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 646
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
Query: 647 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 706
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 698 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 751
Query: 707 TNRQGIFPVSYVEVVK 722
+ GIFP +Y++ ++
Sbjct: 752 --KSGIFPKNYIQFLQ 765
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 113 bits (282), Expect = 8e-25
Identities = 139/557 (24%), Positives = 222/557 (39%), Gaps = 74/557 (13%)
Query: 313 SAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPV---------------P 357
S+ S T RPL S +S N S+P+ P VPP + P
Sbjct: 128 SSDSGKKVPTPAPRPLLLKKSVSSENPTYP-SAPLKPVTVPPRLAGASQAKAYKSLGEGP 186
Query: 358 PLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQ-HE---RPPPLP-- 411
P P K D D + ++ E G +L HE PPPLP
Sbjct: 187 PANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLGLHEDPQSPPPLPAE 246
Query: 412 --------TTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR------SGAPTPSSRAPA-L 456
T + + L S+ G+ G PPR +G P+ + P +
Sbjct: 247 KPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKV 306
Query: 457 SPTRPPKKPLDYVQDHSSGV-FNEASLYQSSIDRSLERPMSSASMASDFRKRR--KSEPA 513
P RPP L + + + FN +SS D L++ S+ + K + K++
Sbjct: 307 PPERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQSNLATGLSKAKSQVFKNQDP 361
Query: 514 VGPPRGL-GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTD 572
V PPR G S+ G V + T++ + S + L +
Sbjct: 362 VLPPRPKPGHPLYSKYMRGDVLV---MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDE 418
Query: 573 MGRSAPRE--RRGTPEKEKLP-AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 629
RS P + P P A ++DF A+ +L+ G+ VY+L KID +WY G
Sbjct: 419 HLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC 478
Query: 630 HGRVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR 688
++GIFP +YV+ + PE R + + +A++ + + ELS +G+
Sbjct: 479 RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEI 538
Query: 689 VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL 748
+IL + V++ W G++ G R GIFP+++VE V EDYP S + S
Sbjct: 539 IILKEYVNEEWARGEVRG--RTGIFPLNFVEPV-------EDYPT-------SGANVLST 582
Query: 749 SSNKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVG 805
+ + N Q P +AL+++T D+L + D I ++E+ D W G
Sbjct: 583 KVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG 642
Query: 806 TSRRTKFFGTFPGNYVK 822
+ + G FP +V+
Sbjct: 643 RLQDRE--GIFPAVFVR 657
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 590 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 646
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
Query: 647 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 706
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 662 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 715
Query: 707 TNRQGIFPVSYVEVVK 722
+ GIFP +Y++ ++
Sbjct: 716 --KSGIFPKNYIQFLQ 729
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 95.5 bits (236), Expect = 2e-19
Identities = 66/206 (32%), Positives = 106/206 (51%), Gaps = 26/206 (12%)
Query: 537 GSSTTLTKSFTS-SSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLP---- 591
GS T T + S SS + +KD +S + G PR + +P +P
Sbjct: 88 GSGTNCTNALRSQSSTVANCSSKDLQSSQ---------GGQQPRVQSWSPPVRGIPQLPC 138
Query: 592 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 651
AKA+Y+++ + +L F KGD + + R++D+NWY GE +G G FP ++V+ + P
Sbjct: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKP----- 193
Query: 652 PARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 711
P PP Q + + K + AD + L K D + +++RVD+NW EG + ++ G
Sbjct: 194 --LPQPPPQCKALYDFEVK-DKEADKDC-LPFAKDDVLTVIRRVDENWAEGML--ADKIG 247
Query: 712 IFPVSYVEVVKKNTKGAEDYPDPPIP 737
IFP+SYVE K ++ PP+P
Sbjct: 248 IFPISYVE-FNSAAKQLIEWDKPPVP 272
Score = 72.0 bits (175), Expect = 2e-12
Identities = 31/52 (59%), Positives = 37/52 (71%)
Query: 770 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 821
+ A+Y YTPR EDELELR+ ++ V E+C DGWF GTS T G FPGNYV
Sbjct: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
Score = 55.8 bits (133), Expect = 2e-07
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 768 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
E + + +Y P++E ELEL+E D++ V +K +DGWF GT +R G FPG++V+ +
Sbjct: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Score = 49.7 bits (117), Expect = 1e-05
Identities = 70/276 (25%), Positives = 103/276 (37%), Gaps = 61/276 (22%)
Query: 413 TPTPVPREPGRK-------------PLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPT 459
+P P P PG PL+ + +T SPS S PS R + P
Sbjct: 630 SPQPAPLMPGSATHTAAISISRASAPLACAAAAPLT-SPSITSASLEAEPSGRIVTVLPG 688
Query: 460 RPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERP--MSSASMASDFRKRRKSEPA---- 513
P D +S +S + D E+ + S AS RK R S PA
Sbjct: 689 LPTSP------DSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTL 742
Query: 514 --------------VGP--PRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRA 557
VGP P G G R VD G TT + + +A
Sbjct: 743 EVELGSAELPLQGAVGPELPPGGGH---GRAGSCPVDGDGPVTTAVAGAALAQDAFHRKA 799
Query: 558 KDRES-------PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 610
+S PR S+L G R E+ ++ V + Q+ EL K+
Sbjct: 800 SSLDSAVPIAPPPRQACSSL---GPVLNESRPVVCERHRV----VVSYPPQSEAELELKE 852
Query: 611 GDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 644
GD V++ +K + W++G + +G+ G+FP S+VE +
Sbjct: 853 GDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 668 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 727
+A Y + EL LRKG+ ++ +R W++G T++ G+FP +YV V T+
Sbjct: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV---TRA 507
Query: 728 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 767
+ +P S + ++ P + +QG G
Sbjct: 508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
Score = 44.7 bits (104), Expect = 4e-04
Identities = 48/216 (22%), Positives = 85/216 (39%), Gaps = 46/216 (21%)
Query: 535 LPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM-GRSAPRERRGTPEKEKLPAK 593
LPG T+ S +S+ +S + D++S + L + G S R+ R +P PA
Sbjct: 686 LPGLPTS-PDSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSP-----PAS 739
Query: 594 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPI--------------- 638
+ + S EL + + G HGR G P+
Sbjct: 740 PTLEVELG-SAELPLQGA--------VGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAAL 790
Query: 639 ---SYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK------------YNFNADTNVELSL 683
++ K + + A P PPP +G + + ++ + EL L
Sbjct: 791 AQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELEL 850
Query: 684 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 719
++GD V + K+ + W++G + + G+FP S+VE
Sbjct: 851 KEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 40.0 bits (92), Expect = 0.009
Identities = 62/300 (20%), Positives = 106/300 (35%), Gaps = 71/300 (23%)
Query: 354 PPVPPLRPRDRSSTEKHDWDPP---DRKVDTRKFRSEPRSIFEYEPGKSSILQH--ERPP 408
PPVP + + SS P D K +T+K S + ++S +H E P
Sbjct: 269 PPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISP 328
Query: 409 PLPTTPTPVPREPGRKPLSSSRLGEVTG-SPSPPPRSGAPTPSSRAPALSPTRPPKKPLD 467
P+ + + P +++R+ E++G S S P + T L T PP P
Sbjct: 329 PVLISSS--------NPTAAARISELSGLSCSAPSQVHISTTG-----LIVTPPPSSP-- 373
Query: 468 YVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASR 527
V S F YQ+++ P + PP L +
Sbjct: 374 -VTTGPSFTFPSDVPYQAALGTL--------------------NPPLPPPPLLAATVLAS 412
Query: 528 TSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK 587
T PG ++ + A PR + + + P+ R
Sbjct: 413 TPPG--------------------ATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSV--- 449
Query: 588 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLT 645
A+Y + + EL +KG+ + + W++G H ++G+FP +YV +T
Sbjct: 450 ----YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
Score = 34.7 bits (78), Expect = 0.37
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 771 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822
+ALYNY + +L+ + D+I + + D+ W+ G G FP N+V+
Sbjct: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHG--EVNGIHGFFPTNFVQ 189
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 90.9 bits (224), Expect = 4e-18
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%)
Query: 593 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 642
KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE
Sbjct: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
Query: 643 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 697
+L +K PA P+ G + ++ V R+ D K+
Sbjct: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381
Query: 698 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 752
+ ++R + + V + + + A D + H + +SS+
Sbjct: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439
Query: 753 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 800
P GE + ALY Y P+ DELEL + ++ V+EKC D
Sbjct: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499
Query: 801 GWFVGTSRRTKFFGTFPGNYV 821
GWF G S RT G FPGNYV
Sbjct: 500 GWFKGASLRTGVSGVFPGNYV 520
Score = 89.7 bits (221), Expect = 1e-17
Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%)
Query: 505 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 558
R R + P PP R + QSA+ T G PGS L+ + S++ S A
Sbjct: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183
Query: 559 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 618
R +P + + L G KA+Y ++ + +L F KGD + + R
Sbjct: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225
Query: 619 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 678
K+D+ WY GE HG G P SY++ + P A P + A Y+F
Sbjct: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272
Query: 679 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 734
+ L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D
Sbjct: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328
Query: 735 PIPHSYSS 742
P P + SS
Sbjct: 329 PCPAAASS 336
Score = 54.7 bits (130), Expect = 3e-07
Identities = 22/55 (40%), Positives = 39/55 (70%)
Query: 768 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822
E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+
Sbjct: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 52.8 bits (125), Expect = 1e-06
Identities = 62/276 (22%), Positives = 101/276 (36%), Gaps = 41/276 (14%)
Query: 400 SILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTG---SPSPP----PRSGAPTPSSR 452
S Q + P +P P R P +S R V S PP PR P S+
Sbjct: 613 SAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAA 672
Query: 453 APALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSI---DRSLERPMSSASM-----ASDF 504
+ P GV + +S + ++ E+ + + +
Sbjct: 673 SAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGAST 732
Query: 505 RKRRKSEPAVGPPR------------GLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPS 552
+K+ +S P+V P +G + +S + GR S + +
Sbjct: 733 KKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRA----GSCPIESEMQGAMGM 788
Query: 553 SPSRAKDRESPRSYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSF 608
P K S T R AP PE + LP + V + Q+ E+
Sbjct: 789 EPLHRK----AGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIEL 844
Query: 609 KKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVE 642
K+GD V++ +K + WY+G + +GR G+FP S+VE
Sbjct: 845 KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 51.2 bits (121), Expect = 4e-06
Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%)
Query: 547 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 593
+SS P + +R D ++ S ST T + R+A +GTP K +LP
Sbjct: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469
Query: 594 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 650
A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP +
Sbjct: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526
Query: 651 QPARPPPPAQPGEIGEAIAK 670
PP G +AK
Sbjct: 527 PAGGAGPPRNNVVGGSPLAK 546
Score = 48.5 bits (114), Expect = 2e-05
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 626 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 675
E E G +G+ P+ S T P + P RP P P E + Y +
Sbjct: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838
Query: 676 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 719
+ +EL ++GD V + K+ + WY+G + R G+FP S+VE
Sbjct: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 39.7 bits (91), Expect = 0.012
Identities = 21/76 (27%), Positives = 34/76 (44%)
Query: 657 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 716
PP + +A Y + + EL L KG+ +L++ W++G T G+FP +
Sbjct: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518
Query: 717 YVEVVKKNTKGAEDYP 732
YV V + G P
Sbjct: 519 YVTPVSRVPAGGAGPP 534
Score = 34.3 bits (77), Expect = 0.48
Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 771 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822
+ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 87.8 bits (216), Expect = 4e-17
Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 33/243 (13%)
Query: 598 FKAQTSKELSFKKGDTVYILRKID-QNWYEGEHHGRVGIFPISYVEKLTPP--------- 647
++AQ ELS GD V +R + + W GE GR G+FP V+++
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 648 -----EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEG 702
+ PA+ P P + ++ ++++ + EL L+ G+ V ++K ++ W+ G
Sbjct: 69 PRCARRRGHPAKHPRPQRWCKVN-----FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123
Query: 703 KIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI--PHSYSSDRIHSLSSNKPQRPVFTH 760
K G + G FP ++VE++ + PD P P ++ SL+ + P + T
Sbjct: 124 KKNG--QLGAFPSNFVELLDSGPPSLGN-PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
Query: 761 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPG 818
+ E ++ L++Y P DEL LR DV+ V+ K D GW+ G + + G FP
Sbjct: 181 SH----PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPD 234
Query: 819 NYV 821
N+V
Sbjct: 235 NFV 237
Score = 72.0 bits (175), Expect = 2e-12
Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 30/166 (18%)
Query: 581 RRGTPEKEKLP---AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 637
RRG P K P K + + + + EL + G+ V ++++I+ W+ G+ +G++G FP
Sbjct: 74 RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
Query: 638 ISYVEKLT--PPEKAQPARP---PPPAQPGEIGEAI------------------AKYNFN 674
++VE L PP P P P P +P ++ +++
Sbjct: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
Query: 675 ADTNVELSLRKGDRVILLKRV--DQNWYEGKIPGTNRQGIFPVSYV 718
+ EL+LR+GD V +L + D+ W+EG+ G R+G+FP ++V
Sbjct: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFV 237
Score = 59.7 bits (143), Expect = 1e-08
Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 22/160 (13%)
Query: 666 EAIAKYNFNADTNVELSLRKGDRVILLKRVD-QNWYEGKIPGTNRQGIFPVSYVEVVKKN 724
E + + A ELSL GD V ++ V + W G+ G R G+FP V+ + +
Sbjct: 2 EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
Query: 725 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDEL 784
+G+ + P R H +PQR + ++Y+P DEL
Sbjct: 60 LRGSGEARRPRCARR----RGHPAKHPRPQRWCKVN-------------FSYSPEQADEL 102
Query: 785 ELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
+L+ ++++++++ +DGW++G ++ G FP N+V+ L
Sbjct: 103 KLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
Score = 50.1 bits (118), Expect = 9e-06
Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 7/107 (6%)
Query: 550 SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFK 609
+P PS + + P SS D +P + T ++ + ++D++ + EL+ +
Sbjct: 149 NPDMPSVSPGPQRPPKLSSLAYD----SPPDYLQTVSHPEV-YRVLFDYQPEAPDELALR 203
Query: 610 KGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR 654
+GD V +L K D+ W+EGE GR G+FP ++V P +K P +
Sbjct: 204 RGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKLVPRK 250
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 87.0 bits (214), Expect = 6e-17
Identities = 83/290 (28%), Positives = 135/290 (46%), Gaps = 54/290 (18%)
Query: 554 PSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK-EKLPAKAVYDFKAQTSKELSFKKGD 612
PS + R+ +T T S+P G EK E L A+A+Y ++A+ L+F K D
Sbjct: 882 PSAGQLRQRSAFTPATATG---SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKND 938
Query: 613 TVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP----------EKAQPAR----PPPP 658
+ +L + D W+ GE G+ G FP SYV+ ++ P PA P
Sbjct: 939 VITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPA 997
Query: 659 AQPGEIGEA-IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSY 717
A+P GE IA Y + + +L+ ++GD VIL+ + D +W+ G + ++ G+FP +Y
Sbjct: 998 AKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKDGDWWTGTVG--DKAGVFPSNY 1054
Query: 718 VEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYT 777
V + K+++G S ++ + SL KP E Q + +YT
Sbjct: 1055 VRL--KDSEG-----------SGTAGKTGSLGK-KP--------------EIAQVIASYT 1086
Query: 778 PRNEDELELRESDVIDVMEKCDDGWFVGTSR---RTKFFGTFPGNYVKRL 824
++L L +I + +K GW+ G + + + G FP NYVK L
Sbjct: 1087 ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 84.7 bits (208), Expect = 3e-16
Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 33/232 (14%)
Query: 594 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 653
A+Y +++ +L+F++GD + + +K D +W+ G + G+FP +YV
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 654 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP--GTNRQ- 710
+ + EI + IA Y A +L+L G +++ K+ W+EG++ G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYT--ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 711 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF 770
G FP +YV+++ T ++ +P + Q G
Sbjct: 1126 GWFPANYVKLLSPGTS--------------------KITPTEPPKSTALAAVCQVIG--- 1162
Query: 771 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822
+Y+YT +N+DEL + +I+V+ K D W+ G G FP NYVK
Sbjct: 1163 --MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ--VGLFPSNYVK 1210
Score = 75.5 bits (184), Expect = 2e-13
Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 570 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 629
L D S + G+ K+ A+ + + A ++L+ G + I +K W+EGE
Sbjct: 1057 LKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGEL 1116
Query: 630 HGR-----VGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL 683
R +G FP +YV+ L+P K P PP + + I Y++ A + EL+
Sbjct: 1117 QARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF 1176
Query: 684 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 720
KG + +L + D +W++G++ G + G+FP +YV++
Sbjct: 1177 NKGQIINVLNKEDPDWWKGEVNG--QVGLFPSNYVKL 1211
Score = 57.8 bits (138), Expect = 4e-08
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 595 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 651
+YD+ AQ EL+F KG + +L K D +W++GE +G+VG+FP +YV+ T + +Q
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 55.5 bits (132), Expect = 2e-07
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 34/243 (13%)
Query: 593 KAVYDFKAQTSKELSFKKGDTVYILRK-IDQN------WYEGEHHGRVGIFPISYVEKLT 645
+A+Y F++++ E++ + GD V + + +D++ W GE G+ G FP +Y EK+
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 646 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 705
E P +P + + + +T L++ + NW
Sbjct: 806 ENEVPAPVKPVTDSTSAPAPKLALR-----ETPAPLAVTSSEP----STTPNNW------ 850
Query: 706 GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHEN-IQ 764
+ +P S E K T + + P S+ ++ S+ P + + +
Sbjct: 851 -ADFSSTWPTSTNE--KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL 907
Query: 765 GGGEPF-----QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 819
G GE QALY + + ++ L ++DVI V+E+ D WF G + K G FP +
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQK--GWFPKS 964
Query: 820 YVK 822
YVK
Sbjct: 965 YVK 967
Score = 32.0 bits (71), Expect = 2.4
Identities = 16/62 (25%), Positives = 31/62 (50%), Gaps = 9/62 (14%)
Query: 770 FQALYNYTPRNEDELELRESDV-------IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822
++ALY + R+ DE+ ++ D+ +D + + GW G + G FP NY +
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT--GWFPANYAE 802
Query: 823 RL 824
++
Sbjct: 803 KI 804
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 87.0 bits (214), Expect = 6e-17
Identities = 83/290 (28%), Positives = 135/290 (46%), Gaps = 54/290 (18%)
Query: 554 PSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK-EKLPAKAVYDFKAQTSKELSFKKGD 612
PS + R+ +T T S+P G EK E L A+A+Y ++A+ L+F K D
Sbjct: 882 PSAGQLRQRSAFTPATATG---SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKND 938
Query: 613 TVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP----------EKAQPAR----PPPP 658
+ +L + D W+ GE G+ G FP SYV+ ++ P PA P
Sbjct: 939 VITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPA 997
Query: 659 AQPGEIGEA-IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSY 717
A+P GE IA Y + + +L+ ++GD VIL+ + D +W+ G + ++ G+FP +Y
Sbjct: 998 AKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKDGDWWTGTVG--DKAGVFPSNY 1054
Query: 718 VEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYT 777
V + K+++G S ++ + SL KP E Q + +YT
Sbjct: 1055 VRL--KDSEG-----------SGTAGKTGSLGK-KP--------------EIAQVIASYT 1086
Query: 778 PRNEDELELRESDVIDVMEKCDDGWFVGTSR---RTKFFGTFPGNYVKRL 824
++L L +I + +K GW+ G + + + G FP NYVK L
Sbjct: 1087 ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 84.7 bits (208), Expect = 3e-16
Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 33/232 (14%)
Query: 594 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 653
A+Y +++ +L+F++GD + + +K D +W+ G + G+FP +YV
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 654 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP--GTNRQ- 710
+ + EI + IA Y A +L+L G +++ K+ W+EG++ G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYT--ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 711 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF 770
G FP +YV+++ T ++ +P + Q G
Sbjct: 1126 GWFPANYVKLLSPGTS--------------------KITPTEPPKSTALAAVCQVIG--- 1162
Query: 771 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822
+Y+YT +N+DEL + +I+V+ K D W+ G G FP NYVK
Sbjct: 1163 --MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ--VGLFPSNYVK 1210
Score = 75.5 bits (184), Expect = 2e-13
Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 570 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 629
L D S + G+ K+ A+ + + A ++L+ G + I +K W+EGE
Sbjct: 1057 LKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGEL 1116
Query: 630 HGR-----VGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL 683
R +G FP +YV+ L+P K P PP + + I Y++ A + EL+
Sbjct: 1117 QARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF 1176
Query: 684 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 720
KG + +L + D +W++G++ G + G+FP +YV++
Sbjct: 1177 NKGQIINVLNKEDPDWWKGEVNG--QVGLFPSNYVKL 1211
Score = 57.8 bits (138), Expect = 4e-08
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 595 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 651
+YD+ AQ EL+F KG + +L K D +W++GE +G+VG+FP +YV+ T + +Q
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 55.5 bits (132), Expect = 2e-07
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 34/243 (13%)
Query: 593 KAVYDFKAQTSKELSFKKGDTVYILRK-IDQN------WYEGEHHGRVGIFPISYVEKLT 645
+A+Y F++++ E++ + GD V + + +D++ W GE G+ G FP +Y EK+
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 646 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 705
E P +P + + + +T L++ + NW
Sbjct: 806 ENEVPAPVKPVTDSTSAPAPKLALR-----ETPAPLAVTSSEP----STTPNNW------ 850
Query: 706 GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHEN-IQ 764
+ +P S E K T + + P S+ ++ S+ P + + +
Sbjct: 851 -ADFSSTWPTSTNE--KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL 907
Query: 765 GGGEPF-----QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 819
G GE QALY + + ++ L ++DVI V+E+ D WF G + K G FP +
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQK--GWFPKS 964
Query: 820 YVK 822
YVK
Sbjct: 965 YVK 967
Score = 32.0 bits (71), Expect = 2.4
Identities = 16/62 (25%), Positives = 31/62 (50%), Gaps = 9/62 (14%)
Query: 770 FQALYNYTPRNEDELELRESDV-------IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822
++ALY + R+ DE+ ++ D+ +D + + GW G + G FP NY +
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT--GWFPANYAE 802
Query: 823 RL 824
++
Sbjct: 803 KI 804
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 84.0 bits (206), Expect = 5e-16
Identities = 94/372 (25%), Positives = 153/372 (41%), Gaps = 67/372 (18%)
Query: 509 KSEPAVGPPRGL--GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSY 566
++E AV P + L S S TS L + + + S S+ + + ++
Sbjct: 793 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 852
Query: 567 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 626
+ T++ G +P +G E L A+A+ + A+ L+F K D + +L + +NW+
Sbjct: 853 TRTVSP-GSVSPIHGQGQVV-ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWF 909
Query: 627 GEHHGRVGIFPISYVEKLTPPEKAQPARPP---------PPAQPGEIGEA-IAKYNFNAD 676
GE HG G FP SYV K+ P + + P P + +GE IA Y +++
Sbjct: 910 GEVHGGRGWFPKSYV-KIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSV 968
Query: 677 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDY 731
+L+ +G+ +++ ++ D W+ G I +R GIFP +YV E +K
Sbjct: 969 EPGDLTFTEGEEILVTQK-DGEWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASN 1025
Query: 732 PDPPIPH---SYSSDRIHSLSSNKPQRPVFTHEN--------IQGGGEPFQ--------- 771
P I +Y + LS Q + +N +Q G+ Q
Sbjct: 1026 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1085
Query: 772 ---------------------ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRT 810
A+Y+Y NEDEL + +I+VM K D W+ G
Sbjct: 1086 KLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV 1145
Query: 811 KFFGTFPGNYVK 822
G FP NYVK
Sbjct: 1146 T--GLFPSNYVK 1155
Score = 74.3 bits (181), Expect = 4e-13
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 36/220 (16%)
Query: 551 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 610
PS+ + KD+ES S S + G K+ A+ + A S++LS
Sbjct: 1003 PSNYVKPKDQESFGSASKS-------------GASNKKPEIAQVTSAYVASGSEQLSLAP 1049
Query: 611 GDTVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEI 664
G + IL+K W++GE R G FP S+V+ L P E+A PA P +
Sbjct: 1050 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------V 1102
Query: 665 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 724
+ IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1103 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS 1160
Query: 725 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 764
DP + ++ + +R + HE IQ
Sbjct: 1161 --------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1192
Score = 58.2 bits (139), Expect = 3e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 536 PGSSTTLTKSFTSS--SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PA 592
PG + K TS +R K R+ +S + +G P R TP +
Sbjct: 1049 PGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG---PSSERATPAFHPVCQV 1105
Query: 593 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 651
A+YD+ A ELSF KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1106 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1164
Score = 46.6 bits (109), Expect = 9e-05
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 593 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 650
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
Query: 651 QPARPPPPAQP 661
+ P P
Sbjct: 796 KAVSPKKALLP 806
Score = 43.9 bits (102), Expect = 6e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 770 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 824
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 735 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 789
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 84.0 bits (206), Expect = 5e-16
Identities = 94/372 (25%), Positives = 153/372 (41%), Gaps = 67/372 (18%)
Query: 509 KSEPAVGPPRGL--GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSY 566
++E AV P + L S S TS L + + + S S+ + + ++
Sbjct: 820 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 879
Query: 567 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 626
+ T++ G +P +G E L A+A+ + A+ L+F K D + +L + +NW+
Sbjct: 880 TRTVSP-GSVSPIHGQGQVV-ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWF 936
Query: 627 GEHHGRVGIFPISYVEKLTPPEKAQPARPP---------PPAQPGEIGEA-IAKYNFNAD 676
GE HG G FP SYV K+ P + + P P + +GE IA Y +++
Sbjct: 937 GEVHGGRGWFPKSYV-KIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSV 995
Query: 677 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDY 731
+L+ +G+ +++ ++ D W+ G I +R GIFP +YV E +K
Sbjct: 996 EPGDLTFTEGEEILVTQK-DGEWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASN 1052
Query: 732 PDPPIPH---SYSSDRIHSLSSNKPQRPVFTHEN--------IQGGGEPFQ--------- 771
P I +Y + LS Q + +N +Q G+ Q
Sbjct: 1053 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1112
Query: 772 ---------------------ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRT 810
A+Y+Y NEDEL + +I+VM K D W+ G
Sbjct: 1113 KLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV 1172
Query: 811 KFFGTFPGNYVK 822
G FP NYVK
Sbjct: 1173 T--GLFPSNYVK 1182
Score = 74.3 bits (181), Expect = 4e-13
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 36/220 (16%)
Query: 551 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 610
PS+ + KD+ES S S + G K+ A+ + A S++LS
Sbjct: 1030 PSNYVKPKDQESFGSASKS-------------GASNKKPEIAQVTSAYVASGSEQLSLAP 1076
Query: 611 GDTVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEI 664
G + IL+K W++GE R G FP S+V+ L P E+A PA P +
Sbjct: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------V 1129
Query: 665 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 724
+ IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1130 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS 1187
Query: 725 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 764
DP + ++ + +R + HE IQ
Sbjct: 1188 --------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1219
Score = 58.2 bits (139), Expect = 3e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 536 PGSSTTLTKSFTSS--SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PA 592
PG + K TS +R K R+ +S + +G P R TP +
Sbjct: 1076 PGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG---PSSERATPAFHPVCQV 1132
Query: 593 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 651
A+YD+ A ELSF KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Score = 46.6 bits (109), Expect = 9e-05
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 593 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 650
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 651 QPARPPPPAQP 661
+ P P
Sbjct: 823 KAVSPKKALLP 833
Score = 43.9 bits (102), Expect = 6e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 770 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 824
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 816
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 84.0 bits (206), Expect = 5e-16
Identities = 94/372 (25%), Positives = 153/372 (41%), Gaps = 67/372 (18%)
Query: 509 KSEPAVGPPRGL--GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSY 566
++E AV P + L S S TS L + + + S S+ + + ++
Sbjct: 820 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 879
Query: 567 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 626
+ T++ G +P +G E L A+A+ + A+ L+F K D + +L + +NW+
Sbjct: 880 TRTVSP-GSVSPIHGQGQVV-ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWF 936
Query: 627 GEHHGRVGIFPISYVEKLTPPEKAQPARPP---------PPAQPGEIGEA-IAKYNFNAD 676
GE HG G FP SYV K+ P + + P P + +GE IA Y +++
Sbjct: 937 GEVHGGRGWFPKSYV-KIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSV 995
Query: 677 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDY 731
+L+ +G+ +++ ++ D W+ G I +R GIFP +YV E +K
Sbjct: 996 EPGDLTFTEGEEILVTQK-DGEWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASN 1052
Query: 732 PDPPIPH---SYSSDRIHSLSSNKPQRPVFTHEN--------IQGGGEPFQ--------- 771
P I +Y + LS Q + +N +Q G+ Q
Sbjct: 1053 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1112
Query: 772 ---------------------ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRT 810
A+Y+Y NEDEL + +I+VM K D W+ G
Sbjct: 1113 KLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV 1172
Query: 811 KFFGTFPGNYVK 822
G FP NYVK
Sbjct: 1173 T--GLFPSNYVK 1182
Score = 74.3 bits (181), Expect = 4e-13
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 36/220 (16%)
Query: 551 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 610
PS+ + KD+ES S S + G K+ A+ + A S++LS
Sbjct: 1030 PSNYVKPKDQESFGSASKS-------------GASNKKPEIAQVTSAYVASGSEQLSLAP 1076
Query: 611 GDTVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEI 664
G + IL+K W++GE R G FP S+V+ L P E+A PA P +
Sbjct: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------V 1129
Query: 665 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 724
+ IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1130 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS 1187
Query: 725 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 764
DP + ++ + +R + HE IQ
Sbjct: 1188 --------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1219
Score = 58.2 bits (139), Expect = 3e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 536 PGSSTTLTKSFTSS--SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PA 592
PG + K TS +R K R+ +S + +G P R TP +
Sbjct: 1076 PGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG---PSSERATPAFHPVCQV 1132
Query: 593 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 651
A+YD+ A ELSF KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Score = 46.6 bits (109), Expect = 9e-05
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 593 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 650
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 651 QPARPPPPAQP 661
+ P P
Sbjct: 823 KAVSPKKALLP 833
Score = 43.9 bits (102), Expect = 6e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 770 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 824
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 816
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 83.2 bits (204), Expect = 9e-16
Identities = 53/165 (32%), Positives = 96/165 (58%), Gaps = 12/165 (7%)
Query: 668 IAKYNFNADTNVELSLRKGDRVILLKRV-DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 726
I +Y+++A + EL++R G+ + +K++ ++ W EG++ G R+G+FP ++V+ +K+ T+
Sbjct: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRETE 62
Query: 727 GAED-YPDPPIPHSYSSDRIHSLSS-NKPQRPVFTH---ENIQGGGEPFQA--LYNYTPR 779
+D P H + + +S+ P + H +NI+ + Q L+ Y P+
Sbjct: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQ 122
Query: 780 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
NEDELEL+ D+ID+ E+ ++GW+ GT G FP N+VK L
Sbjct: 123 NEDELELKVGDIIDINEEVEEGWWSGTLNNK--LGLFPSNFVKEL 165
Score = 55.8 bits (133), Expect = 2e-07
Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 100/325 (30%)
Query: 596 YDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHHGRVGIFPISYVEKL-TPPEKAQPA 653
YD+ A EL+ + G+ + ++K+ ++ W EGE +GR G+FP ++V+++ E +
Sbjct: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
Query: 654 RPPPPAQPGEIGEAIAK--------------------------------YNFNADTNVEL 681
P + G + + + + + EL
Sbjct: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
Query: 682 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG----AED------- 730
L+ GD + + + V++ W+ G + N+ G+FP ++V+ ++ G A+D
Sbjct: 128 ELKVGDIIDINEEVEEGWWSGTL--NNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLA 185
Query: 731 YPDPPIP---------------------------HSYSSDRIHSLSSN------KPQRPV 757
P PIP S ++ + +S+ KP++P+
Sbjct: 186 GPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPL 245
Query: 758 -------------FTHENIQG---GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CD 799
T + +G E + L+ Y NEDEL +E ++I ++ K +
Sbjct: 246 ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
Query: 800 DGWFVGTSRRTKFFGTFPGNYVKRL 824
GW+ G + G FP N+ ++
Sbjct: 306 AGWWRGELNGKE--GVFPDNFAVQI 328
Score = 50.8 bits (120), Expect = 5e-06
Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 5/88 (5%)
Query: 587 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKL 644
K K + ++ ++ EL+FK+G+ ++++ K + W+ GE +G+ G+FP ++ ++
Sbjct: 269 KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
Query: 645 TPPEK--AQPARPPPPAQ-PGEIGEAIA 669
+K +P +PPPPA+ P E IA
Sbjct: 329 NELDKDFPKPKKPPPPAKAPAPKPELIA 356
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 82.8 bits (203), Expect = 1e-15
Identities = 50/162 (30%), Positives = 90/162 (55%), Gaps = 12/162 (7%)
Query: 666 EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNT 725
EAI ++++ A + EL++ G+ + +++ D W+EG+I G R+G+FP ++V +KK
Sbjct: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
Query: 726 KG---AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 782
K P+ P+ S + + LSS R T++ + Q ++Y P+N+D
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSL--LSSETILR---TNKRGERRRRRCQVAFSYLPQNDD 115
Query: 783 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
ELEL+ D+I+V+ + ++GW+ G G FP N++K L
Sbjct: 116 ELELKVGDIIEVVGEVEEGWWEGVLNGKT--GMFPSNFIKEL 155
Score = 66.2 bits (160), Expect = 1e-10
Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)
Query: 587 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 644
K K K ++ ++AQ EL+ K+GD V ++ K ID W+EGE +GR G+FP ++V KL
Sbjct: 267 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 325
Query: 645 TPP----EKAQPARPPPPAQP 661
PP E +P +PPPP+ P
Sbjct: 326 LPPDFEKEGNRPKKPPPPSAP 346
Score = 63.5 bits (153), Expect = 7e-10
Identities = 37/148 (25%), Positives = 73/148 (49%), Gaps = 26/148 (17%)
Query: 596 YDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARP 655
+D++AQ EL+ G+ + +RK D W+EG+ +GR G+FP ++V ++ K P
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67
Query: 656 PPPAQP-------------------GEIGEAIAK-----YNFNADTNVELSLRKGDRVIL 691
P +P + GE + +++ + EL L+ GD + +
Sbjct: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127
Query: 692 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 719
+ V++ W+EG + G + G+FP ++++
Sbjct: 128 VGEVEEGWWEGVLNG--KTGMFPSNFIK 153
Score = 62.4 bits (150), Expect = 2e-09
Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)
Query: 547 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 606
T+ +P P + S T+ + R RR + + + Q EL
Sbjct: 66 TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 117
Query: 607 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 666
K GD + ++ ++++ W+EG +G+ G+FP +++++L+ + E
Sbjct: 118 ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 177
Query: 667 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 726
+ D++ S +G + Q K+ G IF +++ ++ +
Sbjct: 178 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 232
Query: 727 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 786
D+ +P + + ++ P ++ + + ++ Y +N+DEL +
Sbjct: 233 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 288
Query: 787 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 824
+E D++ ++ K D GW+ G + G FP N+VK L
Sbjct: 289 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
Score = 47.8 bits (112), Expect = 4e-05
Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)
Query: 671 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 728
+ + A + EL++++GD V L+ + +D W+EG++ G R+G+FP ++V+++ + +
Sbjct: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 333
Query: 729 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 780
+ P P P S +++R H + P+RP P + P
Sbjct: 334 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 384
Query: 781 EDELELRESDV 791
E +L+L++ V
Sbjct: 385 EPKLDLQKPSV 395
Score = 40.8 bits (94), Expect = 0.005
Identities = 57/225 (25%), Positives = 80/225 (35%), Gaps = 50/225 (22%)
Query: 337 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEP 396
P+ K+ + P PP PP P+ + +TE RK + +K
Sbjct: 328 PDFEKEGNRPKKPP---PPSAPVIKQGAGTTE--------RKHEIKK------------- 363
Query: 397 GKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPAL 456
+ ERP LP T P R+P + V P PR SR AL
Sbjct: 364 -----IPPERPEMLPNR-TEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGAL 417
Query: 457 SPTRP--PKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFR--------K 506
P RP P PL H+ G + L SS+ L++ +S S D
Sbjct: 418 PPRRPERPVGPL----THTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSST 473
Query: 507 RRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 551
+ S P P+ G + S++ L SS + F S SP
Sbjct: 474 EKLSHPTTSRPKATGRRPPSQS------LTSSSLSSPDIFDSPSP 512
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,427,190
Number of Sequences: 37866
Number of extensions: 2462659
Number of successful extensions: 27218
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 408
Number of HSP's successfully gapped in prelim test: 1309
Number of HSP's that attempted gapping in prelim test: 14817
Number of HSP's gapped (non-prelim): 9608
length of query: 824
length of database: 18,247,518
effective HSP length: 111
effective length of query: 713
effective length of database: 14,044,392
effective search space: 10013651496
effective search space used: 10013651496
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.