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Search of human proteins with 224586849
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
(661 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 1361 0.0
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 1330 0.0
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 1285 0.0
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 1258 0.0
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 1226 0.0
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 993 0.0
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 622 e-178
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 555 e-158
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 424 e-118
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 408 e-114
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 406 e-113
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 399 e-111
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 392 e-109
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 282 6e-76
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 282 6e-76
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 258 9e-69
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 228 1e-59
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 107 3e-23
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 103 4e-22
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 103 4e-22
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 96 1e-19
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 91 3e-18
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 88 3e-17
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 87 5e-17
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 87 5e-17
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 84 4e-16
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 84 4e-16
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 84 4e-16
gi|11321634 CD2-associated protein [Homo sapiens] 83 7e-16
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 83 9e-16
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 1361 bits (3522), Expect = 0.0
Identities = 661/661 (100%), Positives = 661/661 (100%)
Query: 1 MNTGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVN 60
MNTGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVN
Sbjct: 1 MNTGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVN 60
Query: 61 GNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSS 120
GNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSS
Sbjct: 61 GNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSS 120
Query: 121 IPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP 180
IPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP
Sbjct: 121 IPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP 180
Query: 181 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 240
DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP
Sbjct: 181 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 240
Query: 241 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPK 300
HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPK
Sbjct: 241 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPK 300
Query: 301 KPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQ 360
KPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQ
Sbjct: 301 KPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQ 360
Query: 361 SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRG 420
SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRG
Sbjct: 361 SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRG 420
Query: 421 TPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK 480
TPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK
Sbjct: 421 TPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK 480
Query: 481 LTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGK 540
LTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGK
Sbjct: 481 LTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGK 540
Query: 541 IPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENI 600
IPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENI
Sbjct: 541 IPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENI 600
Query: 601 QGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKR 660
QGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKR
Sbjct: 601 QGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKR 660
Query: 661 L 661
L
Sbjct: 661 L 661
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 1330 bits (3442), Expect = 0.0
Identities = 658/711 (92%), Positives = 658/711 (92%), Gaps = 53/711 (7%)
Query: 4 GRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNS 63
GRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNS
Sbjct: 21 GRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNS 80
Query: 64 GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL 123
GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL
Sbjct: 81 GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL 140
Query: 124 YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDD 183
YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDD
Sbjct: 141 YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDD 200
Query: 184 TDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP 243
TDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP
Sbjct: 201 TDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP 260
Query: 244 PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP------ 297
PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP
Sbjct: 261 PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTT 320
Query: 298 -----------------------------------------------PPKKPLDYVQDHS 310
PPKKPLDYVQDHS
Sbjct: 321 PTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYVQDHS 380
Query: 311 SGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV 370
SGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV
Sbjct: 381 SGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV 440
Query: 371 DLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK 430
DLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK
Sbjct: 441 DLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK 500
Query: 431 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 490
AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA
Sbjct: 501 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 560
Query: 491 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIF 550
RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIF
Sbjct: 561 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIF 620
Query: 551 PVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQAL 610
PVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQAL
Sbjct: 621 PVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQAL 680
Query: 611 YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 681 YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 1285 bits (3325), Expect = 0.0
Identities = 638/689 (92%), Positives = 638/689 (92%), Gaps = 51/689 (7%)
Query: 1 MNTGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVN 60
MNTGRDSQSPDSA KGFRSVRPNLQDKRSPTQSQITVN
Sbjct: 1 MNTGRDSQSPDSA-----------------------KGFRSVRPNLQDKRSPTQSQITVN 37
Query: 61 GNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSS 120
GNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSS
Sbjct: 38 GNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSS 97
Query: 121 IPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP 180
IPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP
Sbjct: 98 IPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP 157
Query: 181 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 240
DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP
Sbjct: 158 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 217
Query: 241 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP--- 297
HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP
Sbjct: 218 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPTDR 277
Query: 298 -------------------------PPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPM 332
PPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPM
Sbjct: 278 INPDDIDLENEPWYKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPM 337
Query: 333 SSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPS 392
SSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPS
Sbjct: 338 SSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPS 397
Query: 393 RAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 452
RAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 398 RAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 457
Query: 453 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 512
ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 458 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 517
Query: 513 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 572
DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 518 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 577
Query: 573 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 632
IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 578 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 637
Query: 633 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 638 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 1258 bits (3256), Expect = 0.0
Identities = 624/658 (94%), Positives = 624/658 (94%), Gaps = 34/658 (5%)
Query: 4 GRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNS 63
GRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNS
Sbjct: 21 GRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNS 80
Query: 64 GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL 123
GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL
Sbjct: 81 GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL 140
Query: 124 YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDD 183
YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP
Sbjct: 141 YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP--- 197
Query: 184 TDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP 243
GLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP
Sbjct: 198 ------------GLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP 245
Query: 244 PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPKKPL 303
PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP
Sbjct: 246 PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP------ 299
Query: 304 DYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS 363
ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS
Sbjct: 300 -------------ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS 346
Query: 364 RTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPE 423
RTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPE
Sbjct: 347 RTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPE 406
Query: 424 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 483
KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP
Sbjct: 407 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 466
Query: 484 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 543
PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG
Sbjct: 467 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 526
Query: 544 TNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 603
TNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG
Sbjct: 527 TNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 586
Query: 604 GEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
GEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 587 GEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 1226 bits (3173), Expect = 0.0
Identities = 607/660 (91%), Positives = 607/660 (91%), Gaps = 53/660 (8%)
Query: 55 SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD 114
SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD
Sbjct: 165 SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD 224
Query: 115 GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 174
GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI
Sbjct: 225 GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 284
Query: 175 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 234
HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS
Sbjct: 285 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 344
Query: 235 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 294
SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH
Sbjct: 345 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 404
Query: 295 ERP-----------------------------------------------------PPKK 301
ERP PPKK
Sbjct: 405 ERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKK 464
Query: 302 PLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS 361
PLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS
Sbjct: 465 PLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS 524
Query: 362 ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT 421
ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT
Sbjct: 525 ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT 584
Query: 422 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 481
PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL
Sbjct: 585 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 644
Query: 482 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 541
TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI
Sbjct: 645 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 704
Query: 542 PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 601
PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ
Sbjct: 705 PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 764
Query: 602 GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 765 GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 993 bits (2567), Expect = 0.0
Identities = 484/503 (96%), Positives = 484/503 (96%), Gaps = 19/503 (3%)
Query: 159 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 218
TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 9 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 68
Query: 219 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 278
SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 69 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 128
Query: 279 RSIFEYEPGKSSILQHERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMA 338
RSIFEYEPGKSSILQHERP ASLYQSSIDRSLERPMSSASMA
Sbjct: 129 RSIFEYEPGKSSILQHERP-------------------ASLYQSSIDRSLERPMSSASMA 169
Query: 339 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRE 398
SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRE
Sbjct: 170 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRE 229
Query: 399 SPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKID 458
SPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKID
Sbjct: 230 SPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKID 289
Query: 459 QNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVEL 518
QNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVEL
Sbjct: 290 QNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVEL 349
Query: 519 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYS 578
SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYS
Sbjct: 350 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYS 409
Query: 579 SDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDG 638
SDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDG
Sbjct: 410 SDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDG 469
Query: 639 WFVGTSRRTKFFGTFPGNYVKRL 661
WFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 470 WFVGTSRRTKFFGTFPGNYVKRL 492
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 622 bits (1605), Expect = e-178
Identities = 319/383 (83%), Positives = 327/383 (85%), Gaps = 30/383 (7%)
Query: 70 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 129
MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE
Sbjct: 1 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 60
Query: 130 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 189
EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT
Sbjct: 61 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 120
Query: 190 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 249
PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL
Sbjct: 121 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 180
Query: 250 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPKKPLDYVQDH 309
RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP
Sbjct: 181 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP------------ 228
Query: 310 SSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGR 369
ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGR
Sbjct: 229 -------ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGR 281
Query: 370 VDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA 429
VDLPGSSTTLTKSFTSSSPSSPSRAK + + S + G + G P E L
Sbjct: 282 VDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLN------GNPSSE-LDY 334
Query: 430 KAVY----DFKAQTSKELSFKKG 448
+ Y D + + +SFK G
Sbjct: 335 CSTYRQHLDVPRDSPRAISFKNG 357
Score = 555 bits (1431), Expect = e-158
Identities = 295/398 (74%), Positives = 315/398 (79%), Gaps = 13/398 (3%)
Query: 272 RKFRSEPRSIFEYEPGKSSILQHERPPPKKPLDYVQ-DHSSGVFNEASLYQSSIDRSL-E 329
RK S P+ E K+S+ + K D ++ + G + S+ I L +
Sbjct: 708 RKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPD 767
Query: 330 RPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSS 386
P ++S+ R R+S P P L A P + D +P S++ +S
Sbjct: 768 VPERNSSL----RALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANS 822
Query: 387 SPSSPSRA---KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 443
S R +DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL
Sbjct: 823 SCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 882
Query: 444 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 503
SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE
Sbjct: 883 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 942
Query: 504 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 563
AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK
Sbjct: 943 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 1002
Query: 564 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 623
GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL
Sbjct: 1003 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 1062
Query: 624 RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 1063 RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 555 bits (1431), Expect = e-158
Identities = 295/398 (74%), Positives = 315/398 (79%), Gaps = 13/398 (3%)
Query: 272 RKFRSEPRSIFEYEPGKSSILQHERPPPKKPLDYVQ-DHSSGVFNEASLYQSSIDRSL-E 329
RK S P+ E K+S+ + K D ++ + G + S+ I L +
Sbjct: 612 RKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPD 671
Query: 330 RPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSS 386
P ++S+ R R+S P P L A P + D +P S++ +S
Sbjct: 672 VPERNSSL----RALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANS 726
Query: 387 SPSSPSRA---KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 443
S R +DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL
Sbjct: 727 SCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 786
Query: 444 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 503
SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE
Sbjct: 787 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 846
Query: 504 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 563
AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK
Sbjct: 847 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 906
Query: 564 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 623
GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL
Sbjct: 907 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 966
Query: 624 RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 967 RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 402 bits (1032), Expect = e-112
Identities = 215/294 (73%), Positives = 223/294 (75%), Gaps = 45/294 (15%)
Query: 159 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 218
TVDRPKDWYKTMFKQIHMVHKP GLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 9 TVDRPKDWYKTMFKQIHMVHKP---------------GLYNPPYSAQSHPAAKTQTYRPL 53
Query: 219 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 278
SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 54 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 113
Query: 279 RSIFEYEPGKSSILQHERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMA 338
RSIFEYEPGKSSILQHERP ASLYQSSIDRSLERPMSSASMA
Sbjct: 114 RSIFEYEPGKSSILQHERP-------------------ASLYQSSIDRSLERPMSSASMA 154
Query: 339 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRE 398
SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK +
Sbjct: 155 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGD 214
Query: 399 SPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVY----DFKAQTSKELSFKKG 448
+ S + G + G P E L + Y D + + +SFK G
Sbjct: 215 DSKICPSLCSYSGLN------GNPSSE-LDYCSTYRQHLDVPRDSPRAISFKNG 261
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 424 bits (1090), Expect = e-118
Identities = 274/675 (40%), Positives = 370/675 (54%), Gaps = 72/675 (10%)
Query: 5 RDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSG 64
R +S WR + + NG+A SSLAAKG+RSV PNL +S S + +S
Sbjct: 62 RQHESKPDEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSS 118
Query: 65 GAVSPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYPQHAQSLDGT 116
+ + PS AY +N +IV+ Q S S + D
Sbjct: 119 LIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSA 178
Query: 117 TSSSIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMF 171
+ P EKR V+K+ +DE GIP +R T +R KDWYKTMF
Sbjct: 179 PTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMF 235
Query: 172 KQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFK 231
KQIH +++ DDD+D+Y+ Y+++ +P S P +K++ S+ D +
Sbjct: 236 KQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKR 284
Query: 232 DASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSI 291
A+ P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+
Sbjct: 285 SATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSV 335
Query: 292 LQHERPPPK-KPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPA 350
L +E+ P + + G ++ + +R+S+ A
Sbjct: 336 LTNEKMSSAISPTPEISSETPGYIYSSNFHAV---------------------KRESDGA 374
Query: 351 VGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM 410
G L ++ S L G L PSS + KD ESPR + D
Sbjct: 375 PGDLTSLENERQIYKSV----LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA--DY 428
Query: 411 GRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGR 469
S RR +KE PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGR
Sbjct: 429 LESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 488
Query: 470 VGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILL 529
VGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL
Sbjct: 489 VGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLL 547
Query: 530 KRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSN 588
++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S S
Sbjct: 548 RQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQP 607
Query: 589 KPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRR 646
+ Q+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRR
Sbjct: 608 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 667
Query: 647 TKFFGTFPGNYVKRL 661
TK FGTFPGNYVK L
Sbjct: 668 TKQFGTFPGNYVKPL 682
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 408 bits (1049), Expect = e-114
Identities = 276/723 (38%), Positives = 380/723 (52%), Gaps = 112/723 (15%)
Query: 5 RDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSG 64
R +S WR + + NG+A SSLAAKG+RSV PNL +S S + +S
Sbjct: 62 RQHESKPDEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSS 118
Query: 65 GAVSPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYPQHAQSLDGT 116
+ + PS AY +N +IV+ Q S S + D
Sbjct: 119 LIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSA 178
Query: 117 TSSSIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMF 171
+ P EKR V+K+ +DE GIP +R T +R KDWYKTMF
Sbjct: 179 PTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMF 235
Query: 172 KQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFK 231
KQIH +++ DDD+D+Y+ Y+++ +P S P +K++ S+ D +
Sbjct: 236 KQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKR 284
Query: 232 DASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSI 291
A+ P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+
Sbjct: 285 SATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSV 335
Query: 292 LQHER------PPP------------------KKPLDYVQDHSSGVFNEASLYQSSID-- 325
L +E+ P P K+ D + + NE +Y+S ++
Sbjct: 336 LTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 395
Query: 326 -------RSLERPMSSASM-----------------ASDFRKRRKSEPAVGPPRGLGDQS 361
L+RP SSAS +F +RR + + L DQ
Sbjct: 396 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKE----KLLADQR 451
Query: 362 ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT 421
+ D+ + T P+ + L ++ +A R+
Sbjct: 452 RLKREQEEADIAA------RRHTGVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS- 499
Query: 422 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 481
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L
Sbjct: 500 ---EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 556
Query: 482 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 541
P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+I
Sbjct: 557 PPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRI 615
Query: 542 PGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENI 600
PGT+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T +
Sbjct: 616 PGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRS 675
Query: 601 QGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 658
Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYV
Sbjct: 676 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 735
Query: 659 KRL 661
K L
Sbjct: 736 KPL 738
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 406 bits (1044), Expect = e-113
Identities = 277/720 (38%), Positives = 380/720 (52%), Gaps = 114/720 (15%)
Query: 10 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 67
P SA WR + + NG+A SSLAAKG+RSV PNL +S S + +S
Sbjct: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIG 162
Query: 68 SPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYPQHAQSLDGTTSS 119
+ + PS AY +N +IV+ Q S S + D +
Sbjct: 163 TDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ 222
Query: 120 SIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 174
P EKR V+K+ +DE GIP +R T +R KDWYKTMFKQI
Sbjct: 223 EKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQI 279
Query: 175 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 234
H +++ DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+
Sbjct: 280 HKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSAT 328
Query: 235 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 294
P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +
Sbjct: 329 LPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTN 379
Query: 295 ER------PPP------------------KKPLDYVQDHSSGVFNEASLYQSSID----- 325
E+ P P K+ D + + NE +Y+S ++
Sbjct: 380 EKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIP 439
Query: 326 ----RSLERPMSSASM-----------------ASDFRKRRKSEPAVGPPRGLGDQSASR 364
L+RP SSAS +F +RR + + L DQ +
Sbjct: 440 LQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKE----KLLADQRRLK 495
Query: 365 TSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK 424
D+ + T P+ + L ++ +A R+
Sbjct: 496 REQEEADIAA------RRHTGVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS---- 540
Query: 425 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 484
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 541 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 600
Query: 485 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 544
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 601 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 659
Query: 545 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 603
+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q
Sbjct: 660 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTS 719
Query: 604 GEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
+ F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 720 QDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 399 bits (1024), Expect = e-111
Identities = 260/641 (40%), Positives = 349/641 (54%), Gaps = 70/641 (10%)
Query: 40 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 94
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 225 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 284
Query: 95 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 145
Q S S + D + P EKR V+K+
Sbjct: 285 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 344
Query: 146 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQ 205
+DE GIP +R T +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P
Sbjct: 345 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----L 396
Query: 206 SHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPP 265
S P +K++ S+ D + A+ P+P +SS+E++DW+PP
Sbjct: 397 SVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPP 441
Query: 266 DRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPK-KPLDYVQDHSSGVFNEASLYQSSI 324
D+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ P + + G ++ +
Sbjct: 442 DKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAV-- 499
Query: 325 DRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFT 384
+R+S+ A G L ++ S L G L
Sbjct: 500 -------------------KRESDGAPGDLTSLENERQIYKSV----LEGGDIPLQGLSG 536
Query: 385 SSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKEL 443
PSS + KD ESPR + D S RR +KE PA+A +DFKAQT KEL
Sbjct: 537 LKRPSSSASTKDSESPRHFIPA--DYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKEL 594
Query: 444 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 503
+KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GE
Sbjct: 595 PLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGE 653
Query: 504 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-T 562
AIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+
Sbjct: 654 AIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLV 713
Query: 563 KGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDE 620
K DY D P S S S + Q+ T + Q + F QALY+Y P+N+DE
Sbjct: 714 KNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDE 773
Query: 621 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
LELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 774 LELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
Score = 85.9 bits (211), Expect = 1e-16
Identities = 161/701 (22%), Positives = 261/701 (37%), Gaps = 121/701 (17%)
Query: 10 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 67
P SA WR + + NG+A SSLAAKG+RSV PNL +S + S A
Sbjct: 74 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQ-------DATSSSAA 123
Query: 68 SPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQH-AQSLDGTTSSSIPL-YR 125
P +P L ++ Q GT+ T P ++ T S++ PL +
Sbjct: 124 ----------QPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFP 173
Query: 126 SSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT---VDRPKDWYKTMFKQIHMVHKPD- 181
+ ++ + + PH+ P SG I T P + + V +PD
Sbjct: 174 TLDDFIPPHLQRWPHHS--QPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDL 231
Query: 182 -------DDTDMYNTPYTYNAGLYNPPYSAQSHPAA---KTQTYRP--LSKSHSDNSPNA 229
D + + N + G + + + S P++ T P + H+
Sbjct: 232 TGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKR 291
Query: 230 FKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKS 289
S PV V +D + T++ P K ++ + + R + + S
Sbjct: 292 LSSLSDPVSERRV-------GEQDSAPTQEKPTSP--GKAIEKRAKDDSRRVVKSTQDLS 342
Query: 290 SILQHERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEP 349
+ E P + + +D +F + D L P S S+ K S P
Sbjct: 343 DVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYS---FSEDTKSPLSVP 399
Query: 350 AVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKD----RESPRSY-- 403
D + LP S++L S + P + D R P+S
Sbjct: 400 RSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYE 459
Query: 404 -----SSTLTDMGRSAPRERRGTPEKEKLPAKAVY--DFKAQTSKELSFKKGDTVYI--L 454
SS LT+ S+ TPE +Y +F A +E GD +
Sbjct: 460 YQPGKSSVLTNEKMSSAIS--PTPEISSETPGYIYSSNFHA-VKRESDGAPGDLTSLENE 516
Query: 455 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPG--------------- 499
R+I ++ EG G + + +S +++ + + + P P
Sbjct: 517 RQIYKSVLEG---GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHD 573
Query: 500 --EIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 557
E+ A AK++F A T EL L+KGD V + K++DQNWYEG+ G R GIFP +Y+E+
Sbjct: 574 DKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIEL 631
Query: 558 VKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 617
+ PP + K Q T + GE A +N+
Sbjct: 632 L------------PP--------------AEKAQPKKLTPVQVLEYGEAI-AKFNFNGDT 664
Query: 618 EDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 658
+ E+ R+ + I ++ + D+ W+ G T G FP YV
Sbjct: 665 QVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 705
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 392 bits (1007), Expect = e-109
Identities = 292/827 (35%), Positives = 407/827 (49%), Gaps = 204/827 (24%)
Query: 10 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 67
P SA WR + + NG+A SSLAAKG+RSV PNL +S + + G+
Sbjct: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSF 162
Query: 68 SPMSYYQRPFSPSAYSLPAS------LNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSI 121
+P+S FSP +P + ++ + +S DS+ + + SL GT S +
Sbjct: 163 APISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAF 222
Query: 122 P---------------------LYRSSEEEKRVTVI------------------KAPHYP 142
P L + E++KR++ + + P P
Sbjct: 223 PSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSP 282
Query: 143 GIG----------------------PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP 180
G +DE GIP +R T +R KDWYKTMFKQIH +++
Sbjct: 283 GKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR- 338
Query: 181 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 240
DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 339 DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPAR 388
Query: 241 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER---- 296
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 389 SSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRD 439
Query: 297 ------------------------PPPKKPLDYVQDHSSGVFNE---ASLYQSSIDRSLE 329
PPPKK DY S + E +S + + S E
Sbjct: 440 ISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKSSAISPTPEISSE 499
Query: 330 RPMSSASMASDFRK-RRKSEPAVGPPRGLGDQSA---SRTSPGRVDLPGSSTTLTKSFTS 385
P +S+F +R+S+ A G L ++ S G + L G S S ++
Sbjct: 500 TP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSA 557
Query: 386 SSPSSPS-------------------RAKDRE------------------SPRSYSSTLT 408
S+ S S R D+E + R ++ +
Sbjct: 558 STKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIP 617
Query: 409 DMGRSAPRERRGT-----------PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 457
+ ER G E PA+A +DFKAQT KEL +KGD VYI ++I
Sbjct: 618 THHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI 677
Query: 458 DQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVE 517
DQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE
Sbjct: 678 DQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVE 736
Query: 518 LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHS 576
+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S
Sbjct: 737 MSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSS 796
Query: 577 YSSDRI-------HSLSSN-------------KPQRPVFTHENIQGGGEPF--QALYNYT 614
S HSL + + Q+ T + Q + F QALY+Y
Sbjct: 797 PSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYI 856
Query: 615 PRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 857 PQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 903
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 282 bits (722), Expect = 6e-76
Identities = 203/612 (33%), Positives = 294/612 (48%), Gaps = 102/612 (16%)
Query: 108 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY 167
QH Q+ T + S +KR Y GIGPVDESG+P A R++VDRP+DWY
Sbjct: 98 QHTQNWSATWTKD-----SKRRDKRWV-----KYEGIGPVDESGMPIAPRSSVDRPRDWY 147
Query: 168 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPY-SAQSHPAAK---TQTYRPLSKSHS 223
+ MF+QIH PD D +T+ +P + AQ PA + + S HS
Sbjct: 148 RRMFQQIHR-KMPDLQLD-----WTFEEPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHS 201
Query: 224 DNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSST--EKHDWDPPDRKVDTRKFRSEPRSI 281
+ P + + + P LR R++ + W+ ++++T + P+
Sbjct: 202 EELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQ---RPKKP 258
Query: 282 FEYEPGKSSILQHERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDF 341
+PG+ P +P++ + + E S R++E + S +
Sbjct: 259 LVDDPGEK---------PSQPIEVLLERELA---ELSAELDKDLRAIETRLPSPKSSPAP 306
Query: 342 RKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR 401
R+ + P GP SA +S GS+ +L+ + S +D P
Sbjct: 307 RRAPEQRPPAGPA------SAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPS 360
Query: 402 SYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNW 461
S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+NW
Sbjct: 361 STRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 417
Query: 462 YEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLR 521
EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D VELS R
Sbjct: 418 LEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELSFR 476
Query: 522 KGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK-----------------KNTKG 564
KG+ + L+++V++NWYEG+I GT RQGIFP SYV+V + + T
Sbjct: 477 KGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAA 536
Query: 565 AEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG--------- 604
A P P + S D I P+R F+ +N+ G
Sbjct: 537 ARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGP 596
Query: 605 ------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRR 646
P++A+Y Y P+NEDELELRE D +DVM++CDDGWFVG SRR
Sbjct: 597 SHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRR 656
Query: 647 TKFFGTFPGNYV 658
T+ FGTFPGNYV
Sbjct: 657 TQKFGTFPGNYV 668
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 506 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 558
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 282 bits (722), Expect = 6e-76
Identities = 227/695 (32%), Positives = 315/695 (45%), Gaps = 160/695 (23%)
Query: 40 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 94
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 257 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 316
Query: 95 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 145
Q S S + D + P EKR V+K+
Sbjct: 317 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 376
Query: 146 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQ 205
+DE GIP +R T +R KDWYKTMFKQIH +++ + + Y Y + S +
Sbjct: 377 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEE 433
Query: 206 SHPAAKTQTY---RPLSKSHSDNSP------NAFKDASSPVPPPHVPP------------ 244
+P T + P KS D+S + +D SP+ P
Sbjct: 434 DNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVK 493
Query: 245 -----PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER--- 296
P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 494 RSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSR 553
Query: 297 -------------------------PPPKKPLDYV---------QDHSSGVFNEASLYQS 322
PPPKK DY +D + + + SL Q+
Sbjct: 554 DISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQT 613
Query: 323 SIDRSLER------------PMSSASM--------------ASDFRK-RRKSEPAVGPPR 355
++ LE+ P SSA +S+F +R+S+ A G
Sbjct: 614 ELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 673
Query: 356 GLGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS-------------------R 393
L ++ S G + L G S S ++S+ S S R
Sbjct: 674 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR 733
Query: 394 AKDRE------------------SPRSYSSTLTDMGRSAPRERRGT-----------PEK 424
D+E + R ++ + + ER G
Sbjct: 734 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS 793
Query: 425 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 484
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 794 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 853
Query: 485 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 544
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 854 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 912
Query: 545 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYS 578
+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 913 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPS 947
Score = 102 bits (254), Expect = 1e-21
Identities = 44/55 (80%), Positives = 51/55 (92%)
Query: 607 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
+QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 42.0 bits (97), Expect = 0.002
Identities = 53/212 (25%), Positives = 79/212 (37%), Gaps = 37/212 (17%)
Query: 306 VQDHSSGVFNEASLY-----QSSIDRSLERPMSSASMASDFRKR-----RKSEPAVGPPR 355
V SSG+ ++ L S+ L SS S +R+ RK+E G R
Sbjct: 1080 VHTPSSGIHQDSFLQLPLGSSDSVISQLSDAFSSQSKRQPWREESGQYERKAERGAGE-R 1138
Query: 356 GLGDQSASRTS---PGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLT---- 408
G G S+ S P V S+ + S P + P S +
Sbjct: 1139 GPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRG 1198
Query: 409 --DMGRSAPR----------ERRGTPEKEKLPA-----KAVYDFKAQTSKELSFKKGDTV 451
GR A R +RR TP++ + +A+Y + Q EL + GD V
Sbjct: 1199 GEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIV 1258
Query: 452 YILRKIDQNWYEG--EHHGRVGIFPISYVEKL 481
++ K D W+ G + G FP +YV+ L
Sbjct: 1259 DVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 38.1 bits (87), Expect = 0.026
Identities = 18/51 (35%), Positives = 29/51 (56%)
Query: 506 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 556
A Y++ + EL LR GD V ++++ D W+ G T + G FP +YV+
Sbjct: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
Score = 37.7 bits (86), Expect = 0.034
Identities = 103/497 (20%), Positives = 182/497 (36%), Gaps = 76/497 (15%)
Query: 10 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 67
P SA WR + + NG+A SSLAAKG+RSV PNL +S + S A
Sbjct: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQ-------DATSSSAA 155
Query: 68 SPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQH-AQSLDGTTSSSIPL-YR 125
P +P L ++ Q GT+ T P ++ T S++ PL +
Sbjct: 156 ----------QPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFP 205
Query: 126 SSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT---VDRPKDWYKTMFKQIHMVHKPD- 181
+ ++ + + PH+ P SG I T P + + V +PD
Sbjct: 206 TLDDFIPPHLQRWPHHS--QPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDL 263
Query: 182 -------DDTDMYNTPYTYNAGLYNPPYSAQSHPAA---KTQTYRP--LSKSHSDNSPNA 229
D + + N + G + + + S P++ T P + H+
Sbjct: 264 TGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKR 323
Query: 230 FKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKS 289
S PV V +D + T++ P K ++ + + R + + S
Sbjct: 324 LSSLSDPVSERRV-------GEQDSAPTQEKPTSP--GKAIEKRAKDDSRRVVKSTQDLS 374
Query: 290 SILQHERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEP 349
+ E P + + +D +F + +++ + D E P + + +++
Sbjct: 375 DVSMDEVGIPLRNTERSKDWYKTMFKQ--IHKLNRDTPEENPYFPTYKFPELPEIQQTSE 432
Query: 350 AVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFT--SSSPSSPSRAK------DRESPR 401
P AS SP D + SF+ + SP S R+K D E
Sbjct: 433 EDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVV 492
Query: 402 SYSSTLTDMGRSA------------PRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGD 449
S+TL RS+ P +++ K + K++Y+++ S L+ +K
Sbjct: 493 KRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMS 552
Query: 450 TVYILRKID---QNWYE 463
+ID + WY+
Sbjct: 553 RDISPEEIDLKNEPWYK 569
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 258 bits (660), Expect = 9e-69
Identities = 184/541 (34%), Positives = 264/541 (48%), Gaps = 136/541 (25%)
Query: 181 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 240
DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 476 DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPAR 525
Query: 241 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER---- 296
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 526 SSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRD 576
Query: 297 ------------------------PPPKKPLDYV---------QDHSSGVFNEASLYQSS 323
PPPKK DY +D + + + SL Q+
Sbjct: 577 ISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTE 636
Query: 324 IDRSLER------------PMSSASM--------------ASDFRK-RRKSEPAVGPPRG 356
++ LE+ P SSA +S+F +R+S+ A G
Sbjct: 637 LEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTS 696
Query: 357 LGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS-------------------RA 394
L ++ S G + L G S S ++S+ S S R
Sbjct: 697 LENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRH 756
Query: 395 KDRE------------------SPRSYSSTLTDMGRSAPRERRGT-----------PEKE 425
D+E + R ++ + + ER G E
Sbjct: 757 DDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSE 816
Query: 426 KLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPE 485
PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P E
Sbjct: 817 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 876
Query: 486 KAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 545
KAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+
Sbjct: 877 KAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 935
Query: 546 RQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 604
RQGIFP++YV+V+K+ K DY D P S S S + + + + +G G
Sbjct: 936 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAG 995
Query: 605 E 605
E
Sbjct: 996 E 996
Score = 158 bits (399), Expect = 2e-38
Identities = 192/745 (25%), Positives = 287/745 (38%), Gaps = 182/745 (24%)
Query: 40 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 94
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 257 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 316
Query: 95 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 145
Q S S + D + P EKR V+K+
Sbjct: 317 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 376
Query: 146 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPY-------------- 191
+DE GIP +R T +R KDWYKTMFKQIH +++ + + Y Y
Sbjct: 377 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEE 433
Query: 192 TYNAGLYNPPYSA--------------QSHPAAKTQTYRPLSKSHSD-NSP--NAFKDAS 234
T + + +P S+P + SD SP + +D
Sbjct: 434 TKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSDLYSPRYSFSEDTK 493
Query: 235 SPVPPPH-----------------VPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSE 277
SP+ P P+P +SS+E++DW+PPD+KVDTRK+R+E
Sbjct: 494 SPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE 553
Query: 278 PRSIFEYEPGKSSILQHE----------------------------RPPPKKPLDYV--- 306
P+SI+EY+PGKSS+L +E +PPPKK DY
Sbjct: 554 PKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGD 613
Query: 307 ------QDHSSGVFNEASLYQSSIDRSLER------------PMSSA------------- 335
+D + + + SL Q+ ++ LE+ P SSA
Sbjct: 614 CSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPG 673
Query: 336 -SMASDFRK-RRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSR 393
+S+F +R+S+ A G L ++ S L G L PSS +
Sbjct: 674 YIYSSNFHAVKRESDGAPGDLTSLENERQIYKSV----LEGGDIPLQGLSGLKRPSSSAS 729
Query: 394 AKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYI 453
KD ESPR + + + RR +KEKL A + Q +++ ++ V
Sbjct: 730 TKDSESPRHFIPA-DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVI- 787
Query: 454 LRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNAD 513
+ E G + I K + +PAR AK++F A
Sbjct: 788 --PTHHQFITNERFG--DLLNIDDTAKRKSGSEMRPAR--------------AKFDFKAQ 829
Query: 514 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI 573
T EL L+KGD V + K++DQNWYEG+ G R GIFP +Y+E++ PP
Sbjct: 830 TLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELL------------PP- 874
Query: 574 PHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVME 633
+ K Q T + GE A +N+ + E+ R+ + I ++
Sbjct: 875 -------------AEKAQPKKLTPVQVLEYGEAI-AKFNFNGDTQVEMSFRKGERITLLR 920
Query: 634 KCDDGWFVGTSRRTKFFGTFPGNYV 658
+ D+ W+ G T G FP YV
Sbjct: 921 QVDENWYEGRIPGTSRQGIFPITYV 945
Score = 148 bits (373), Expect = 2e-35
Identities = 105/298 (35%), Positives = 146/298 (48%), Gaps = 49/298 (16%)
Query: 400 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 459
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 865 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 924
Query: 460 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPP------ 494
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 925 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
Query: 495 ---------PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 545
+ G G I+K + ++V L R+ D N E PG
Sbjct: 985 QYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLS-----DLNTPEESRPGKP 1039
Query: 546 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 605
FP S E +++ G + ++ R S QR V T + Q +
Sbjct: 1040 LGSAFPGSEAEQTERHRGGEQ-------AGRKAARRGGSQQPQAQQRRV-TPDRSQTSQD 1091
Query: 606 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1092 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
Score = 36.2 bits (82), Expect = 0.099
Identities = 22/44 (50%), Positives = 27/44 (61%), Gaps = 5/44 (11%)
Query: 10 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRS 51
P SA WR + + NG+A SSLAAKG+RSV PNL +S
Sbjct: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKS 146
Score = 31.6 bits (70), Expect = 2.4
Identities = 14/56 (25%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 606 PFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
P +A +++ + EL L++ D++ + ++ D W+ G G FP Y++ L
Sbjct: 819 PARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR--VGIFPRTYIELL 872
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 228 bits (582), Expect = 1e-59
Identities = 131/319 (41%), Positives = 175/319 (54%), Gaps = 59/319 (18%)
Query: 395 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 454
+D P S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI
Sbjct: 12 RDFVYPSSTRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIH 68
Query: 455 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADT 514
+++D+NW EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D
Sbjct: 69 KEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDL 127
Query: 515 NVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK--------------- 559
VELS RKG+ + L+++V++NWYEG+I GT RQGIFP SYV+V +
Sbjct: 128 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPT 187
Query: 560 --KNTKGAEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG-- 604
+ T A P P + S D I P+R F+ +N+ G
Sbjct: 188 SPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPA 247
Query: 605 -------------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGW 639
P++A+Y Y P+NEDELELRE D +DVM++CDDGW
Sbjct: 248 LSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGW 307
Query: 640 FVGTSRRTKFFGTFPGNYV 658
FVG SRRT+ FGTFPGNYV
Sbjct: 308 FVGVSRRTQKFGTFPGNYV 326
Score = 69.7 bits (169), Expect = 8e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 477 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 536
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 16 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 75
Query: 537 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 596
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 76 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 110
Query: 597 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 656
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 111 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 166
Query: 657 YVK 659
YV+
Sbjct: 167 YVQ 169
Score = 45.4 bits (106), Expect = 2e-04
Identities = 33/126 (26%), Positives = 60/126 (47%), Gaps = 12/126 (9%)
Query: 361 SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR---SYS---STLTDMGRSA 414
SA R+ +DL G ++ F+ + + ++ +P S+S S D+G S+
Sbjct: 205 SALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSS 264
Query: 415 PRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGI 472
P T + P +A+Y ++ Q EL ++GD V ++++ D W+ G + G
Sbjct: 265 PN----TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGT 320
Query: 473 FPISYV 478
FP +YV
Sbjct: 321 FPGNYV 326
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 506 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 558
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 107 bits (268), Expect = 3e-23
Identities = 97/396 (24%), Positives = 167/396 (42%), Gaps = 55/396 (13%)
Query: 295 ERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR--KSEPAVG 352
ERPPP K + + FN +SS D L++ S+ + K + K++ V
Sbjct: 345 ERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVL 399
Query: 353 PPR-----------------GLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK 395
PPR G+ ++ +PG + + T ++ + +
Sbjct: 400 PPRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGE 459
Query: 396 DRESPR-SYSSTLTDMGRSAPRERRGTPEKEKLP-------AKAVYDFKAQTSKELSFKK 447
D S +T + R R P + P A ++DF A+ +L+
Sbjct: 460 DTGRVHLSQMKIITPLDEHL-RSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTS 518
Query: 448 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIA 506
G+ VY+L KID +WY G ++GIFP +YV+ + PE R + + +A
Sbjct: 519 GEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVA 578
Query: 507 KYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAE 566
++ + + ELS +G+ +IL + V++ W G++ G R GIFP+++VE V E
Sbjct: 579 RFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPLNFVEPV-------E 629
Query: 567 DYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDELEL 623
DYP S + S + + N Q P +AL+++T D+L
Sbjct: 630 DYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSF 682
Query: 624 RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 659
+ D I ++E+ D W G + + G FP +V+
Sbjct: 683 KRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 716
Score = 84.3 bits (207), Expect = 3e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 427 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 483
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
Query: 484 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 543
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 721 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 774
Query: 544 TNRQGIFPVSYVEVVK 559
+ GIFP +Y++ ++
Sbjct: 775 --KSGIFPKNYIQFLQ 788
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 103 bits (258), Expect = 4e-22
Identities = 98/375 (26%), Positives = 163/375 (43%), Gaps = 36/375 (9%)
Query: 295 ERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR--KSEPAVG 352
ERPPP K + + FN +SS D L++ S+ + K + K++ V
Sbjct: 309 ERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVL 363
Query: 353 PPRGL-GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMG 411
PPR G S+ G V + T++ + S + L +
Sbjct: 364 PPRPKPGHPLYSKYMRGDVLV---MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL 420
Query: 412 RSAPRE--RRGTPEKEKLP-AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHG 468
RS P + P P A ++DF A+ +L+ G+ VY+L KID +WY G
Sbjct: 421 RSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRN 480
Query: 469 RVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVI 527
++GIFP +YV+ + PE R + + +A++ + + ELS +G+ +I
Sbjct: 481 QIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIII 540
Query: 528 LLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSS 587
L + V++ W G++ G R GIFP+++VE V EDYP S + S
Sbjct: 541 LKEYVNEEWARGEVRG--RTGIFPLNFVEPV-------EDYPT-------SGANVLSTKV 584
Query: 588 NKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTS 644
+ + N Q P +AL+++T D+L + D I ++E+ D W G
Sbjct: 585 PLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRL 644
Query: 645 RRTKFFGTFPGNYVK 659
+ + G FP +V+
Sbjct: 645 QDRE--GIFPAVFVR 657
Score = 84.3 bits (207), Expect = 3e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 427 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 483
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
Query: 484 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 543
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 662 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 715
Query: 544 TNRQGIFPVSYVEVVK 559
+ GIFP +Y++ ++
Sbjct: 716 --KSGIFPKNYIQFLQ 729
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 103 bits (258), Expect = 4e-22
Identities = 98/375 (26%), Positives = 163/375 (43%), Gaps = 36/375 (9%)
Query: 295 ERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR--KSEPAVG 352
ERPPP K + + FN +SS D L++ S+ + K + K++ V
Sbjct: 345 ERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVL 399
Query: 353 PPRGL-GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMG 411
PPR G S+ G V + T++ + S + L +
Sbjct: 400 PPRPKPGHPLYSKYMRGDVLV---MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL 456
Query: 412 RSAPRE--RRGTPEKEKLP-AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHG 468
RS P + P P A ++DF A+ +L+ G+ VY+L KID +WY G
Sbjct: 457 RSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRN 516
Query: 469 RVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVI 527
++GIFP +YV+ + PE R + + +A++ + + ELS +G+ +I
Sbjct: 517 QIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIII 576
Query: 528 LLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSS 587
L + V++ W G++ G R GIFP+++VE V EDYP S + S
Sbjct: 577 LKEYVNEEWARGEVRG--RTGIFPLNFVEPV-------EDYPT-------SGANVLSTKV 620
Query: 588 NKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTS 644
+ + N Q P +AL+++T D+L + D I ++E+ D W G
Sbjct: 621 PLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRL 680
Query: 645 RRTKFFGTFPGNYVK 659
+ + G FP +V+
Sbjct: 681 QDRE--GIFPAVFVR 693
Score = 84.3 bits (207), Expect = 3e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 427 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 483
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
Query: 484 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 543
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 698 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 751
Query: 544 TNRQGIFPVSYVEVVK 559
+ GIFP +Y++ ++
Sbjct: 752 --KSGIFPKNYIQFLQ 765
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 95.5 bits (236), Expect = 1e-19
Identities = 66/206 (32%), Positives = 106/206 (51%), Gaps = 26/206 (12%)
Query: 374 GSSTTLTKSFTS-SSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLP---- 428
GS T T + S SS + +KD +S + G PR + +P +P
Sbjct: 88 GSGTNCTNALRSQSSTVANCSSKDLQSSQ---------GGQQPRVQSWSPPVRGIPQLPC 138
Query: 429 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 488
AKA+Y+++ + +L F KGD + + R++D+NWY GE +G G FP ++V+ + P
Sbjct: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKP----- 193
Query: 489 PARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 548
P PP Q + + K + AD + L K D + +++RVD+NW EG + ++ G
Sbjct: 194 --LPQPPPQCKALYDFEVK-DKEADKDC-LPFAKDDVLTVIRRVDENWAEGML--ADKIG 247
Query: 549 IFPVSYVEVVKKNTKGAEDYPDPPIP 574
IFP+SYVE K ++ PP+P
Sbjct: 248 IFPISYVE-FNSAAKQLIEWDKPPVP 272
Score = 72.0 bits (175), Expect = 2e-12
Identities = 31/52 (59%), Positives = 37/52 (71%)
Query: 607 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 658
+ A+Y YTPR EDELELR+ ++ V E+C DGWF GTS T G FPGNYV
Sbjct: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
Score = 55.8 bits (133), Expect = 1e-07
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 605 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
E + + +Y P++E ELEL+E D++ V +K +DGWF GT +R G FPG++V+ +
Sbjct: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Score = 44.7 bits (104), Expect = 3e-04
Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 505 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 564
+A Y + EL LRKG+ ++ +R W++G T++ G+FP +YV V T+
Sbjct: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV---TRA 507
Query: 565 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 604
+ +P S + ++ P + +QG G
Sbjct: 508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
Score = 44.7 bits (104), Expect = 3e-04
Identities = 48/216 (22%), Positives = 85/216 (39%), Gaps = 46/216 (21%)
Query: 372 LPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM-GRSAPRERRGTPEKEKLPAK 430
LPG T+ S +S+ +S + D++S + L + G S R+ R +P PA
Sbjct: 686 LPGLPTS-PDSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSP-----PAS 739
Query: 431 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPI--------------- 475
+ + S EL + + G HGR G P+
Sbjct: 740 PTLEVELG-SAELPLQGA--------VGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAAL 790
Query: 476 ---SYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK------------YNFNADTNVELSL 520
++ K + + A P PPP +G + + ++ + EL L
Sbjct: 791 AQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELEL 850
Query: 521 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 556
++GD V + K+ + W++G + + G+FP S+VE
Sbjct: 851 KEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 44.7 bits (104), Expect = 3e-04
Identities = 18/54 (33%), Positives = 34/54 (62%), Gaps = 2/54 (3%)
Query: 430 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 481
+ V + Q+ EL K+GD V++ +K + W++G + +G+ G+FP S+VE +
Sbjct: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Score = 39.3 bits (90), Expect = 0.012
Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 2/54 (3%)
Query: 431 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLT 482
A+Y + + EL +KG+ + + W++G H ++G+FP +YV +T
Sbjct: 452 AIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
Score = 34.7 bits (78), Expect = 0.29
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 608 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 659
+ALYNY + +L+ + D+I + + D+ W+ G G FP N+V+
Sbjct: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHG--EVNGIHGFFPTNFVQ 189
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 90.9 bits (224), Expect = 3e-18
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%)
Query: 430 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 479
KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE
Sbjct: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
Query: 480 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 534
+L +K PA P+ G + ++ V R+ D K+
Sbjct: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381
Query: 535 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 589
+ ++R + + V + + + A D + H + +SS+
Sbjct: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439
Query: 590 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 637
P GE + ALY Y P+ DELEL + ++ V+EKC D
Sbjct: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499
Query: 638 GWFVGTSRRTKFFGTFPGNYV 658
GWF G S RT G FPGNYV
Sbjct: 500 GWFKGASLRTGVSGVFPGNYV 520
Score = 89.7 bits (221), Expect = 8e-18
Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%)
Query: 342 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 395
R R + P PP R + QSA+ T G PGS L+ + S++ S A
Sbjct: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183
Query: 396 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 455
R +P + + L G KA+Y ++ + +L F KGD + + R
Sbjct: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225
Query: 456 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 515
K+D+ WY GE HG G P SY++ + P A P + A Y+F
Sbjct: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272
Query: 516 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 571
+ L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D
Sbjct: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328
Query: 572 PIPHSYSS 579
P P + SS
Sbjct: 329 PCPAAASS 336
Score = 54.7 bits (130), Expect = 3e-07
Identities = 22/55 (40%), Positives = 39/55 (70%)
Query: 605 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 659
E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+
Sbjct: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 51.2 bits (121), Expect = 3e-06
Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%)
Query: 384 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 430
+SS P + +R D ++ S ST T + R+A +GTP K +LP
Sbjct: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469
Query: 431 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 487
A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP +
Sbjct: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526
Query: 488 QPARPPPPAQPGEIGEAIAK 507
PP G +AK
Sbjct: 527 PAGGAGPPRNNVVGGSPLAK 546
Score = 49.3 bits (116), Expect = 1e-05
Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 6/84 (7%)
Query: 402 SYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSFKKGDTVYILRKI 457
S T R AP PE + LP + V + Q+ E+ K+GD V++ +K
Sbjct: 797 SLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR 856
Query: 458 DQNWYEG--EHHGRVGIFPISYVE 479
+ WY+G + +GR G+FP S+VE
Sbjct: 857 EDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 48.5 bits (114), Expect = 2e-05
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 463 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 512
E E G +G+ P+ S T P + P RP P P E + Y +
Sbjct: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838
Query: 513 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 556
+ +EL ++GD V + K+ + WY+G + R G+FP S+VE
Sbjct: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 39.7 bits (91), Expect = 0.009
Identities = 21/76 (27%), Positives = 34/76 (44%)
Query: 494 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 553
PP + +A Y + + EL L KG+ +L++ W++G T G+FP +
Sbjct: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518
Query: 554 YVEVVKKNTKGAEDYP 569
YV V + G P
Sbjct: 519 YVTPVSRVPAGGAGPP 534
Score = 34.3 bits (77), Expect = 0.38
Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 608 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 659
+ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 87.8 bits (216), Expect = 3e-17
Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 33/243 (13%)
Query: 435 FKAQTSKELSFKKGDTVYILRKID-QNWYEGEHHGRVGIFPISYVEKLTPP--------- 484
++AQ ELS GD V +R + + W GE GR G+FP V+++
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 485 -----EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEG 539
+ PA+ P P + ++ ++++ + EL L+ G+ V ++K ++ W+ G
Sbjct: 69 PRCARRRGHPAKHPRPQRWCKVN-----FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123
Query: 540 KIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI--PHSYSSDRIHSLSSNKPQRPVFTH 597
K G + G FP ++VE++ + PD P P ++ SL+ + P + T
Sbjct: 124 KKNG--QLGAFPSNFVELLDSGPPSLGN-PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
Query: 598 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPG 655
+ E ++ L++Y P DEL LR DV+ V+ K D GW+ G + + G FP
Sbjct: 181 SH----PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPD 234
Query: 656 NYV 658
N+V
Sbjct: 235 NFV 237
Score = 72.0 bits (175), Expect = 2e-12
Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 30/166 (18%)
Query: 418 RRGTPEKEKLP---AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 474
RRG P K P K + + + + EL + G+ V ++++I+ W+ G+ +G++G FP
Sbjct: 74 RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
Query: 475 ISYVEKLT--PPEKAQPARP---PPPAQPGEIGEAI------------------AKYNFN 511
++VE L PP P P P P +P ++ +++
Sbjct: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
Query: 512 ADTNVELSLRKGDRVILLKRV--DQNWYEGKIPGTNRQGIFPVSYV 555
+ EL+LR+GD V +L + D+ W+EG+ G R+G+FP ++V
Sbjct: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFV 237
Score = 59.7 bits (143), Expect = 8e-09
Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 22/160 (13%)
Query: 503 EAIAKYNFNADTNVELSLRKGDRVILLKRVD-QNWYEGKIPGTNRQGIFPVSYVEVVKKN 561
E + + A ELSL GD V ++ V + W G+ G R G+FP V+ + +
Sbjct: 2 EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
Query: 562 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDEL 621
+G+ + P R H +PQR + ++Y+P DEL
Sbjct: 60 LRGSGEARRPRCARR----RGHPAKHPRPQRWCKVN-------------FSYSPEQADEL 102
Query: 622 ELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
+L+ ++++++++ +DGW++G ++ G FP N+V+ L
Sbjct: 103 KLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
Score = 50.1 bits (118), Expect = 7e-06
Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 7/107 (6%)
Query: 387 SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFK 446
+P PS + + P SS D +P + T ++ + ++D++ + EL+ +
Sbjct: 149 NPDMPSVSPGPQRPPKLSSLAYD----SPPDYLQTVSHPEV-YRVLFDYQPEAPDELALR 203
Query: 447 KGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR 491
+GD V +L K D+ W+EGE GR G+FP ++V P +K P +
Sbjct: 204 RGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKLVPRK 250
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 87.0 bits (214), Expect = 5e-17
Identities = 83/290 (28%), Positives = 135/290 (46%), Gaps = 54/290 (18%)
Query: 391 PSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK-EKLPAKAVYDFKAQTSKELSFKKGD 449
PS + R+ +T T S+P G EK E L A+A+Y ++A+ L+F K D
Sbjct: 882 PSAGQLRQRSAFTPATATG---SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKND 938
Query: 450 TVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP----------EKAQPAR----PPPP 495
+ +L + D W+ GE G+ G FP SYV+ ++ P PA P
Sbjct: 939 VITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPA 997
Query: 496 AQPGEIGEA-IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSY 554
A+P GE IA Y + + +L+ ++GD VIL+ + D +W+ G + ++ G+FP +Y
Sbjct: 998 AKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKDGDWWTGTVG--DKAGVFPSNY 1054
Query: 555 VEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYT 614
V + K+++G S ++ + SL KP E Q + +YT
Sbjct: 1055 VRL--KDSEG-----------SGTAGKTGSLGK-KP--------------EIAQVIASYT 1086
Query: 615 PRNEDELELRESDVIDVMEKCDDGWFVGTSR---RTKFFGTFPGNYVKRL 661
++L L +I + +K GW+ G + + + G FP NYVK L
Sbjct: 1087 ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 84.7 bits (208), Expect = 2e-16
Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 33/232 (14%)
Query: 431 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 490
A+Y +++ +L+F++GD + + +K D +W+ G + G+FP +YV
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 491 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP--GTNRQ- 547
+ + EI + IA Y A +L+L G +++ K+ W+EG++ G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYT--ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 548 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF 607
G FP +YV+++ T ++ +P + Q G
Sbjct: 1126 GWFPANYVKLLSPGTS--------------------KITPTEPPKSTALAAVCQVIG--- 1162
Query: 608 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 659
+Y+YT +N+DEL + +I+V+ K D W+ G G FP NYVK
Sbjct: 1163 --MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ--VGLFPSNYVK 1210
Score = 75.5 bits (184), Expect = 1e-13
Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 407 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 466
L D S + G+ K+ A+ + + A ++L+ G + I +K W+EGE
Sbjct: 1057 LKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGEL 1116
Query: 467 HGR-----VGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL 520
R +G FP +YV+ L+P K P PP + + I Y++ A + EL+
Sbjct: 1117 QARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF 1176
Query: 521 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 557
KG + +L + D +W++G++ G + G+FP +YV++
Sbjct: 1177 NKGQIINVLNKEDPDWWKGEVNG--QVGLFPSNYVKL 1211
Score = 57.8 bits (138), Expect = 3e-08
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 432 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 488
+YD+ AQ EL+F KG + +L K D +W++GE +G+VG+FP +YV+ T + +Q
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 55.5 bits (132), Expect = 2e-07
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 34/243 (13%)
Query: 430 KAVYDFKAQTSKELSFKKGDTVYILRK-IDQN------WYEGEHHGRVGIFPISYVEKLT 482
+A+Y F++++ E++ + GD V + + +D++ W GE G+ G FP +Y EK+
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 483 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 542
E P +P + + + +T L++ + NW
Sbjct: 806 ENEVPAPVKPVTDSTSAPAPKLALR-----ETPAPLAVTSSEP----STTPNNW------ 850
Query: 543 GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHEN-IQ 601
+ +P S E K T + + P S+ ++ S+ P + + +
Sbjct: 851 -ADFSSTWPTSTNE--KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL 907
Query: 602 GGGEPF-----QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 656
G GE QALY + + ++ L ++DVI V+E+ D WF G + K G FP +
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQK--GWFPKS 964
Query: 657 YVK 659
YVK
Sbjct: 965 YVK 967
Score = 32.0 bits (71), Expect = 1.9
Identities = 16/62 (25%), Positives = 31/62 (50%), Gaps = 9/62 (14%)
Query: 607 FQALYNYTPRNEDELELRESDV-------IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 659
++ALY + R+ DE+ ++ D+ +D + + GW G + G FP NY +
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT--GWFPANYAE 802
Query: 660 RL 661
++
Sbjct: 803 KI 804
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 87.0 bits (214), Expect = 5e-17
Identities = 83/290 (28%), Positives = 135/290 (46%), Gaps = 54/290 (18%)
Query: 391 PSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK-EKLPAKAVYDFKAQTSKELSFKKGD 449
PS + R+ +T T S+P G EK E L A+A+Y ++A+ L+F K D
Sbjct: 882 PSAGQLRQRSAFTPATATG---SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKND 938
Query: 450 TVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP----------EKAQPAR----PPPP 495
+ +L + D W+ GE G+ G FP SYV+ ++ P PA P
Sbjct: 939 VITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPA 997
Query: 496 AQPGEIGEA-IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSY 554
A+P GE IA Y + + +L+ ++GD VIL+ + D +W+ G + ++ G+FP +Y
Sbjct: 998 AKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKDGDWWTGTVG--DKAGVFPSNY 1054
Query: 555 VEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYT 614
V + K+++G S ++ + SL KP E Q + +YT
Sbjct: 1055 VRL--KDSEG-----------SGTAGKTGSLGK-KP--------------EIAQVIASYT 1086
Query: 615 PRNEDELELRESDVIDVMEKCDDGWFVGTSR---RTKFFGTFPGNYVKRL 661
++L L +I + +K GW+ G + + + G FP NYVK L
Sbjct: 1087 ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 84.7 bits (208), Expect = 2e-16
Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 33/232 (14%)
Query: 431 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 490
A+Y +++ +L+F++GD + + +K D +W+ G + G+FP +YV
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 491 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP--GTNRQ- 547
+ + EI + IA Y A +L+L G +++ K+ W+EG++ G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYT--ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 548 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF 607
G FP +YV+++ T ++ +P + Q G
Sbjct: 1126 GWFPANYVKLLSPGTS--------------------KITPTEPPKSTALAAVCQVIG--- 1162
Query: 608 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 659
+Y+YT +N+DEL + +I+V+ K D W+ G G FP NYVK
Sbjct: 1163 --MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ--VGLFPSNYVK 1210
Score = 75.5 bits (184), Expect = 1e-13
Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 407 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 466
L D S + G+ K+ A+ + + A ++L+ G + I +K W+EGE
Sbjct: 1057 LKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGEL 1116
Query: 467 HGR-----VGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL 520
R +G FP +YV+ L+P K P PP + + I Y++ A + EL+
Sbjct: 1117 QARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF 1176
Query: 521 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 557
KG + +L + D +W++G++ G + G+FP +YV++
Sbjct: 1177 NKGQIINVLNKEDPDWWKGEVNG--QVGLFPSNYVKL 1211
Score = 57.8 bits (138), Expect = 3e-08
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 432 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 488
+YD+ AQ EL+F KG + +L K D +W++GE +G+VG+FP +YV+ T + +Q
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 55.5 bits (132), Expect = 2e-07
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 34/243 (13%)
Query: 430 KAVYDFKAQTSKELSFKKGDTVYILRK-IDQN------WYEGEHHGRVGIFPISYVEKLT 482
+A+Y F++++ E++ + GD V + + +D++ W GE G+ G FP +Y EK+
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 483 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 542
E P +P + + + +T L++ + NW
Sbjct: 806 ENEVPAPVKPVTDSTSAPAPKLALR-----ETPAPLAVTSSEP----STTPNNW------ 850
Query: 543 GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHEN-IQ 601
+ +P S E K T + + P S+ ++ S+ P + + +
Sbjct: 851 -ADFSSTWPTSTNE--KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL 907
Query: 602 GGGEPF-----QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 656
G GE QALY + + ++ L ++DVI V+E+ D WF G + K G FP +
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQK--GWFPKS 964
Query: 657 YVK 659
YVK
Sbjct: 965 YVK 967
Score = 32.0 bits (71), Expect = 1.9
Identities = 16/62 (25%), Positives = 31/62 (50%), Gaps = 9/62 (14%)
Query: 607 FQALYNYTPRNEDELELRESDV-------IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 659
++ALY + R+ DE+ ++ D+ +D + + GW G + G FP NY +
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT--GWFPANYAE 802
Query: 660 RL 661
++
Sbjct: 803 KI 804
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 84.0 bits (206), Expect = 4e-16
Identities = 94/372 (25%), Positives = 153/372 (41%), Gaps = 67/372 (18%)
Query: 346 KSEPAVGPPRGL--GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSY 403
++E AV P + L S S TS L + + + S S+ + + ++
Sbjct: 793 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 852
Query: 404 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 463
+ T++ G +P +G E L A+A+ + A+ L+F K D + +L + +NW+
Sbjct: 853 TRTVSP-GSVSPIHGQGQVV-ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWF 909
Query: 464 GEHHGRVGIFPISYVEKLTPPEKAQPARPP---------PPAQPGEIGEA-IAKYNFNAD 513
GE HG G FP SYV K+ P + + P P + +GE IA Y +++
Sbjct: 910 GEVHGGRGWFPKSYV-KIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSV 968
Query: 514 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDY 568
+L+ +G+ +++ ++ D W+ G I +R GIFP +YV E +K
Sbjct: 969 EPGDLTFTEGEEILVTQK-DGEWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASN 1025
Query: 569 PDPPIPH---SYSSDRIHSLSSNKPQRPVFTHEN--------IQGGGEPFQ--------- 608
P I +Y + LS Q + +N +Q G+ Q
Sbjct: 1026 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1085
Query: 609 ---------------------ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRT 647
A+Y+Y NEDEL + +I+VM K D W+ G
Sbjct: 1086 KLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV 1145
Query: 648 KFFGTFPGNYVK 659
G FP NYVK
Sbjct: 1146 T--GLFPSNYVK 1155
Score = 74.3 bits (181), Expect = 3e-13
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 36/220 (16%)
Query: 388 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 447
PS+ + KD+ES S S + G K+ A+ + A S++LS
Sbjct: 1003 PSNYVKPKDQESFGSASKS-------------GASNKKPEIAQVTSAYVASGSEQLSLAP 1049
Query: 448 GDTVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEI 501
G + IL+K W++GE R G FP S+V+ L P E+A PA P +
Sbjct: 1050 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------V 1102
Query: 502 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 561
+ IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1103 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS 1160
Query: 562 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 601
DP + ++ + +R + HE IQ
Sbjct: 1161 --------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1192
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 373 PGSSTTLTKSFTSS--SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PA 429
PG + K TS +R K R+ +S + +G P R TP +
Sbjct: 1049 PGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG---PSSERATPAFHPVCQV 1105
Query: 430 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 488
A+YD+ A ELSF KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1106 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1164
Score = 46.6 bits (109), Expect = 7e-05
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 430 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 487
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
Query: 488 QPARPPPPAQP 498
+ P P
Sbjct: 796 KAVSPKKALLP 806
Score = 43.9 bits (102), Expect = 5e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 607 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 661
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 735 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 789
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 84.0 bits (206), Expect = 4e-16
Identities = 94/372 (25%), Positives = 153/372 (41%), Gaps = 67/372 (18%)
Query: 346 KSEPAVGPPRGL--GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSY 403
++E AV P + L S S TS L + + + S S+ + + ++
Sbjct: 820 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 879
Query: 404 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 463
+ T++ G +P +G E L A+A+ + A+ L+F K D + +L + +NW+
Sbjct: 880 TRTVSP-GSVSPIHGQGQVV-ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWF 936
Query: 464 GEHHGRVGIFPISYVEKLTPPEKAQPARPP---------PPAQPGEIGEA-IAKYNFNAD 513
GE HG G FP SYV K+ P + + P P + +GE IA Y +++
Sbjct: 937 GEVHGGRGWFPKSYV-KIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSV 995
Query: 514 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDY 568
+L+ +G+ +++ ++ D W+ G I +R GIFP +YV E +K
Sbjct: 996 EPGDLTFTEGEEILVTQK-DGEWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASN 1052
Query: 569 PDPPIPH---SYSSDRIHSLSSNKPQRPVFTHEN--------IQGGGEPFQ--------- 608
P I +Y + LS Q + +N +Q G+ Q
Sbjct: 1053 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1112
Query: 609 ---------------------ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRT 647
A+Y+Y NEDEL + +I+VM K D W+ G
Sbjct: 1113 KLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV 1172
Query: 648 KFFGTFPGNYVK 659
G FP NYVK
Sbjct: 1173 T--GLFPSNYVK 1182
Score = 74.3 bits (181), Expect = 3e-13
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 36/220 (16%)
Query: 388 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 447
PS+ + KD+ES S S + G K+ A+ + A S++LS
Sbjct: 1030 PSNYVKPKDQESFGSASKS-------------GASNKKPEIAQVTSAYVASGSEQLSLAP 1076
Query: 448 GDTVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEI 501
G + IL+K W++GE R G FP S+V+ L P E+A PA P +
Sbjct: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------V 1129
Query: 502 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 561
+ IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1130 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS 1187
Query: 562 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 601
DP + ++ + +R + HE IQ
Sbjct: 1188 --------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1219
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 373 PGSSTTLTKSFTSS--SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PA 429
PG + K TS +R K R+ +S + +G P R TP +
Sbjct: 1076 PGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG---PSSERATPAFHPVCQV 1132
Query: 430 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 488
A+YD+ A ELSF KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Score = 46.6 bits (109), Expect = 7e-05
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 430 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 487
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 488 QPARPPPPAQP 498
+ P P
Sbjct: 823 KAVSPKKALLP 833
Score = 43.9 bits (102), Expect = 5e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 607 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 661
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 816
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 84.0 bits (206), Expect = 4e-16
Identities = 94/372 (25%), Positives = 153/372 (41%), Gaps = 67/372 (18%)
Query: 346 KSEPAVGPPRGL--GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSY 403
++E AV P + L S S TS L + + + S S+ + + ++
Sbjct: 820 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 879
Query: 404 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 463
+ T++ G +P +G E L A+A+ + A+ L+F K D + +L + +NW+
Sbjct: 880 TRTVSP-GSVSPIHGQGQVV-ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWF 936
Query: 464 GEHHGRVGIFPISYVEKLTPPEKAQPARPP---------PPAQPGEIGEA-IAKYNFNAD 513
GE HG G FP SYV K+ P + + P P + +GE IA Y +++
Sbjct: 937 GEVHGGRGWFPKSYV-KIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSV 995
Query: 514 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDY 568
+L+ +G+ +++ ++ D W+ G I +R GIFP +YV E +K
Sbjct: 996 EPGDLTFTEGEEILVTQK-DGEWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASN 1052
Query: 569 PDPPIPH---SYSSDRIHSLSSNKPQRPVFTHEN--------IQGGGEPFQ--------- 608
P I +Y + LS Q + +N +Q G+ Q
Sbjct: 1053 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1112
Query: 609 ---------------------ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRT 647
A+Y+Y NEDEL + +I+VM K D W+ G
Sbjct: 1113 KLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV 1172
Query: 648 KFFGTFPGNYVK 659
G FP NYVK
Sbjct: 1173 T--GLFPSNYVK 1182
Score = 74.3 bits (181), Expect = 3e-13
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 36/220 (16%)
Query: 388 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 447
PS+ + KD+ES S S + G K+ A+ + A S++LS
Sbjct: 1030 PSNYVKPKDQESFGSASKS-------------GASNKKPEIAQVTSAYVASGSEQLSLAP 1076
Query: 448 GDTVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEI 501
G + IL+K W++GE R G FP S+V+ L P E+A PA P +
Sbjct: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------V 1129
Query: 502 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 561
+ IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1130 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS 1187
Query: 562 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 601
DP + ++ + +R + HE IQ
Sbjct: 1188 --------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1219
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 373 PGSSTTLTKSFTSS--SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PA 429
PG + K TS +R K R+ +S + +G P R TP +
Sbjct: 1076 PGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG---PSSERATPAFHPVCQV 1132
Query: 430 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 488
A+YD+ A ELSF KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Score = 46.6 bits (109), Expect = 7e-05
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 430 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 487
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 488 QPARPPPPAQP 498
+ P P
Sbjct: 823 KAVSPKKALLP 833
Score = 43.9 bits (102), Expect = 5e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 607 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 661
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 816
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 83.2 bits (204), Expect = 7e-16
Identities = 53/165 (32%), Positives = 96/165 (58%), Gaps = 12/165 (7%)
Query: 505 IAKYNFNADTNVELSLRKGDRVILLKRV-DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 563
I +Y+++A + EL++R G+ + +K++ ++ W EG++ G R+G+FP ++V+ +K+ T+
Sbjct: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRETE 62
Query: 564 GAED-YPDPPIPHSYSSDRIHSLSS-NKPQRPVFTH---ENIQGGGEPFQA--LYNYTPR 616
+D P H + + +S+ P + H +NI+ + Q L+ Y P+
Sbjct: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQ 122
Query: 617 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
NEDELEL+ D+ID+ E+ ++GW+ GT G FP N+VK L
Sbjct: 123 NEDELELKVGDIIDINEEVEEGWWSGTLNNK--LGLFPSNFVKEL 165
Score = 55.8 bits (133), Expect = 1e-07
Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 100/325 (30%)
Query: 433 YDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHHGRVGIFPISYVEKL-TPPEKAQPA 490
YD+ A EL+ + G+ + ++K+ ++ W EGE +GR G+FP ++V+++ E +
Sbjct: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
Query: 491 RPPPPAQPGEIGEAIAK--------------------------------YNFNADTNVEL 518
P + G + + + + + EL
Sbjct: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
Query: 519 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG----AED------- 567
L+ GD + + + V++ W+ G + N+ G+FP ++V+ ++ G A+D
Sbjct: 128 ELKVGDIIDINEEVEEGWWSGTL--NNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLA 185
Query: 568 YPDPPIP---------------------------HSYSSDRIHSLSSN------KPQRPV 594
P PIP S ++ + +S+ KP++P+
Sbjct: 186 GPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPL 245
Query: 595 -------------FTHENIQG---GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CD 636
T + +G E + L+ Y NEDEL +E ++I ++ K +
Sbjct: 246 ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
Query: 637 DGWFVGTSRRTKFFGTFPGNYVKRL 661
GW+ G + G FP N+ ++
Sbjct: 306 AGWWRGELNGKE--GVFPDNFAVQI 328
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 5/88 (5%)
Query: 424 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKL 481
K K + ++ ++ EL+FK+G+ ++++ K + W+ GE +G+ G+FP ++ ++
Sbjct: 269 KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
Query: 482 TPPEK--AQPARPPPPAQ-PGEIGEAIA 506
+K +P +PPPPA+ P E IA
Sbjct: 329 NELDKDFPKPKKPPPPAKAPAPKPELIA 356
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 82.8 bits (203), Expect = 9e-16
Identities = 50/162 (30%), Positives = 90/162 (55%), Gaps = 12/162 (7%)
Query: 503 EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNT 562
EAI ++++ A + EL++ G+ + +++ D W+EG+I G R+G+FP ++V +KK
Sbjct: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
Query: 563 KG---AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 619
K P+ P+ S + + LSS R T++ + Q ++Y P+N+D
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSL--LSSETILR---TNKRGERRRRRCQVAFSYLPQNDD 115
Query: 620 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
ELEL+ D+I+V+ + ++GW+ G G FP N++K L
Sbjct: 116 ELELKVGDIIEVVGEVEEGWWEGVLNGKT--GMFPSNFIKEL 155
Score = 66.2 bits (160), Expect = 9e-11
Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)
Query: 424 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 481
K K K ++ ++AQ EL+ K+GD V ++ K ID W+EGE +GR G+FP ++V KL
Sbjct: 267 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 325
Query: 482 TPP----EKAQPARPPPPAQP 498
PP E +P +PPPP+ P
Sbjct: 326 LPPDFEKEGNRPKKPPPPSAP 346
Score = 63.5 bits (153), Expect = 6e-10
Identities = 37/148 (25%), Positives = 73/148 (49%), Gaps = 26/148 (17%)
Query: 433 YDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARP 492
+D++AQ EL+ G+ + +RK D W+EG+ +GR G+FP ++V ++ K P
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67
Query: 493 PPPAQP-------------------GEIGEAIAK-----YNFNADTNVELSLRKGDRVIL 528
P +P + GE + +++ + EL L+ GD + +
Sbjct: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127
Query: 529 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 556
+ V++ W+EG + G + G+FP ++++
Sbjct: 128 VGEVEEGWWEGVLNG--KTGMFPSNFIK 153
Score = 62.4 bits (150), Expect = 1e-09
Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)
Query: 384 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 443
T+ +P P + S T+ + R RR + + + Q EL
Sbjct: 66 TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 117
Query: 444 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 503
K GD + ++ ++++ W+EG +G+ G+FP +++++L+ + E
Sbjct: 118 ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 177
Query: 504 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 563
+ D++ S +G + Q K+ G IF +++ ++ +
Sbjct: 178 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 232
Query: 564 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 623
D+ +P + + ++ P ++ + + ++ Y +N+DEL +
Sbjct: 233 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 288
Query: 624 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 661
+E D++ ++ K D GW+ G + G FP N+VK L
Sbjct: 289 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)
Query: 508 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 565
+ + A + EL++++GD V L+ + +D W+EG++ G R+G+FP ++V+++ + +
Sbjct: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 333
Query: 566 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 617
+ P P P S +++R H + P+RP P + P
Sbjct: 334 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 384
Query: 618 EDELELRESDV 628
E +L+L++ V
Sbjct: 385 EPKLDLQKPSV 395
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,839,022
Number of Sequences: 37866
Number of extensions: 1773835
Number of successful extensions: 15016
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 277
Number of HSP's successfully gapped in prelim test: 474
Number of HSP's that attempted gapping in prelim test: 11135
Number of HSP's gapped (non-prelim): 3631
length of query: 661
length of database: 18,247,518
effective HSP length: 109
effective length of query: 552
effective length of database: 14,120,124
effective search space: 7794308448
effective search space used: 7794308448
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.