Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 224586846
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
(731 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 1499 0.0
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 1360 0.0
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 1330 0.0
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 1278 0.0
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 1116 0.0
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 816 0.0
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 555 e-158
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 555 e-158
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 409 e-114
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 406 e-113
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 399 e-111
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 384 e-106
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 357 2e-98
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 280 4e-75
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 276 5e-74
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 256 7e-68
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 228 1e-59
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 117 3e-26
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 114 4e-25
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 113 7e-25
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 96 2e-19
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 91 4e-18
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 88 3e-17
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 87 5e-17
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 87 5e-17
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 84 5e-16
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 84 5e-16
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 84 5e-16
gi|11321634 CD2-associated protein [Homo sapiens] 83 8e-16
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 83 1e-15
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 1499 bits (3880), Expect = 0.0
Identities = 731/731 (100%), Positives = 731/731 (100%)
Query: 1 MSVTLTSVKRVQSSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVR 60
MSVTLTSVKRVQSSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVR
Sbjct: 1 MSVTLTSVKRVQSSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVR 60
Query: 61 PNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDST 120
PNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDST
Sbjct: 61 PNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDST 120
Query: 121 DTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRP 180
DTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRP
Sbjct: 121 DTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRP 180
Query: 181 KDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHS 240
KDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHS
Sbjct: 181 KDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHS 240
Query: 241 DNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFE 300
DNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFE
Sbjct: 241 DNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFE 300
Query: 301 YEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRA 360
YEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRA
Sbjct: 301 YEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRA 360
Query: 361 PALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPA 420
PALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPA
Sbjct: 361 PALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPA 420
Query: 421 VGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM 480
VGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM
Sbjct: 421 VGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM 480
Query: 481 GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRV 540
GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRV
Sbjct: 481 GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRV 540
Query: 541 GIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLK 600
GIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLK
Sbjct: 541 GIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLK 600
Query: 601 RVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKP 660
RVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKP
Sbjct: 601 RVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKP 660
Query: 661 QRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFF 720
QRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFF
Sbjct: 661 QRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFF 720
Query: 721 GTFPGNYVKRL 731
GTFPGNYVKRL
Sbjct: 721 GTFPGNYVKRL 731
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 1360 bits (3520), Expect = 0.0
Identities = 660/660 (100%), Positives = 660/660 (100%)
Query: 72 SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD 131
SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD
Sbjct: 165 SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD 224
Query: 132 GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 191
GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI
Sbjct: 225 GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 284
Query: 192 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 251
HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS
Sbjct: 285 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 344
Query: 252 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 311
SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH
Sbjct: 345 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 404
Query: 312 ERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKK 371
ERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKK
Sbjct: 405 ERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKK 464
Query: 372 PLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS 431
PLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS
Sbjct: 465 PLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS 524
Query: 432 ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT 491
ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT
Sbjct: 525 ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT 584
Query: 492 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 551
PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL
Sbjct: 585 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 644
Query: 552 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 611
TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI
Sbjct: 645 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 704
Query: 612 PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 671
PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ
Sbjct: 705 PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 764
Query: 672 GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 765 GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 1330 bits (3442), Expect = 0.0
Identities = 658/711 (92%), Positives = 658/711 (92%), Gaps = 53/711 (7%)
Query: 21 GRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNS 80
GRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNS
Sbjct: 4 GRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNS 63
Query: 81 GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL 140
GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL
Sbjct: 64 GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL 123
Query: 141 YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDD 200
YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDD
Sbjct: 124 YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDD 183
Query: 201 TDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP 260
TDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP
Sbjct: 184 TDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP 243
Query: 261 PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTT 320
PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPP
Sbjct: 244 PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPP---- 299
Query: 321 PTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYVQDHS 380
KKPLDYVQDHS
Sbjct: 300 -------------------------------------------------KKPLDYVQDHS 310
Query: 381 SGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV 440
SGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV
Sbjct: 311 SGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV 370
Query: 441 DLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK 500
DLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK
Sbjct: 371 DLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK 430
Query: 501 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 560
AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA
Sbjct: 431 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 490
Query: 561 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIF 620
RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIF
Sbjct: 491 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIF 550
Query: 621 PVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQAL 680
PVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQAL
Sbjct: 551 PVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQAL 610
Query: 681 YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 611 YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 1278 bits (3307), Expect = 0.0
Identities = 640/712 (89%), Positives = 642/712 (90%), Gaps = 50/712 (7%)
Query: 21 GRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNS 80
GRDSQSPDSA KGFRSVRPNLQDKRSPTQSQITVNGNS
Sbjct: 4 GRDSQSPDSA-----------------------KGFRSVRPNLQDKRSPTQSQITVNGNS 40
Query: 81 GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL 140
GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL
Sbjct: 41 GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL 100
Query: 141 YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDD 200
YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDD
Sbjct: 101 YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDD 160
Query: 201 TDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP 260
TDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP
Sbjct: 161 TDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP 220
Query: 261 PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPP-LPT 319
PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP +
Sbjct: 221 PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPTDRINP 280
Query: 320 TPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYVQDH 379
+ EP K S G PPKKPLDYVQDH
Sbjct: 281 DDIDLENEPWYKFFSELEFGR--------------------------PPPKKPLDYVQDH 314
Query: 380 SSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGR 439
SSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGR
Sbjct: 315 SSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGR 374
Query: 440 VDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA 499
VDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA
Sbjct: 375 VDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA 434
Query: 500 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 559
KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP
Sbjct: 435 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 494
Query: 560 ARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI 619
ARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI
Sbjct: 495 ARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI 554
Query: 620 FPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQA 679
FPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQA
Sbjct: 555 FPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQA 614
Query: 680 LYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
LYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 615 LYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 1116 bits (2887), Expect = 0.0
Identities = 579/731 (79%), Positives = 598/731 (81%), Gaps = 87/731 (11%)
Query: 1 MSVTLTSVKRVQSSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVR 60
MSVTLTSVKRVQSSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVR
Sbjct: 1 MSVTLTSVKRVQSSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVR 60
Query: 61 PNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDST 120
PNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDST
Sbjct: 61 PNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDST 120
Query: 121 DTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRP 180
DTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRP
Sbjct: 121 DTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRP 180
Query: 181 KDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHS 240
KDWYKTMFKQIHMVHKP GLYNPPYSAQSHPAAKTQTYRPLSKSHS
Sbjct: 181 KDWYKTMFKQIHMVHKP---------------GLYNPPYSAQSHPAAKTQTYRPLSKSHS 225
Query: 241 DNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFE 300
DNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFE
Sbjct: 226 DNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFE 285
Query: 301 YEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRA 360
YEPGKSSILQHERP L + E +P+SS+ + S
Sbjct: 286 YEPGKSSILQHERPASLYQSSIDRSLE---RPMSSASMA-----------SDFRKRRKSE 331
Query: 361 PALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPA 420
PA+ P R + S ++S R ++ P SS ++ F S P+
Sbjct: 332 PAVGPPRG---------------LGDQSASRTSPGR-VDLPGSSTTLTKSFTSSSPSSPS 375
Query: 421 VGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM 480
++ R SP +S++S TLTDM
Sbjct: 376 ---------RAKDRESP-------------RSYSS--------------------TLTDM 393
Query: 481 GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRV 540
GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRV
Sbjct: 394 GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRV 453
Query: 541 GIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLK 600
GIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLK
Sbjct: 454 GIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLK 513
Query: 601 RVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKP 660
RVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKP
Sbjct: 514 RVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKP 573
Query: 661 QRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFF 720
QRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFF
Sbjct: 574 QRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFF 633
Query: 721 GTFPGNYVKRL 731
GTFPGNYVKRL
Sbjct: 634 GTFPGNYVKRL 644
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 816 bits (2107), Expect = 0.0
Identities = 419/556 (75%), Positives = 438/556 (78%), Gaps = 72/556 (12%)
Query: 176 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 235
TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 9 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 68
Query: 236 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 295
SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 69 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 128
Query: 296 RSIFEYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPT 355
RSIFEYEPGKSSILQHERP L + E +P+SS+ + S
Sbjct: 129 RSIFEYEPGKSSILQHERPASLYQSSIDRSLE---RPMSSASMA-----------SDFRK 174
Query: 356 PSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR 415
PA+ P R + S ++S R ++ P SS ++ F
Sbjct: 175 RRKSEPAVGPPRG---------------LGDQSASRTSPGR-VDLPGSSTTLTKSFTSSS 218
Query: 416 KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSS 475
S P+ ++ R SP +S++S
Sbjct: 219 PSSPS---------RAKDRESP-------------RSYSS-------------------- 236
Query: 476 TLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE 535
TLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE
Sbjct: 237 TLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE 296
Query: 536 HHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR 595
HHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR
Sbjct: 297 HHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR 356
Query: 596 VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL 655
VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL
Sbjct: 357 VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL 416
Query: 656 SSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSR 715
SSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSR
Sbjct: 417 SSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSR 476
Query: 716 RTKFFGTFPGNYVKRL 731
RTKFFGTFPGNYVKRL
Sbjct: 477 RTKFFGTFPGNYVKRL 492
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 555 bits (1429), Expect = e-158
Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)
Query: 409 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 464
S R R+S P P L A P + D +P S++ +SS R
Sbjct: 677 SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 735
Query: 465 --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 522
+DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 736 ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 795
Query: 523 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 582
ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 796 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 855
Query: 583 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 642
DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 856 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 915
Query: 643 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 702
IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 916 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 975
Query: 703 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 976 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 263 bits (671), Expect = 6e-70
Identities = 132/179 (73%), Positives = 136/179 (75%), Gaps = 17/179 (9%)
Query: 176 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 235
TVDRPKDWYKTMFKQIHMVHKP GLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 9 TVDRPKDWYKTMFKQIHMVHKP---------------GLYNPPYSAQSHPAAKTQTYRPL 53
Query: 236 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 295
SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 54 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 113
Query: 296 RSIFEYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAP 354
RSIFEYEPGKSSILQHERP L + + R R S+S + P G P
Sbjct: 114 RSIFEYEPGKSSILQHERPASL--YQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPP 170
Score = 167 bits (424), Expect = 2e-41
Identities = 115/234 (49%), Positives = 129/234 (55%), Gaps = 37/234 (15%)
Query: 315 PPLPTTPTPVPREPGRKPLSSSRLGEV------TGSPSPPPRSGAPTPSSRAPALSPTR- 367
PP P + +PLS S SP PPP P P R S T
Sbjct: 35 PPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEK 94
Query: 368 ----PPKKPLD-------------YVQDHSSGVFNE--ASLYQSSIDRSLERPMSSASMA 408
PP + +D Y SS + +E ASLYQSSIDRSLERPMSSASMA
Sbjct: 95 HDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMA 154
Query: 409 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRE 468
SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK +
Sbjct: 155 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGD 214
Query: 469 SPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVY----DFKAQTSKELSFKKG 518
+ S + G + G P E L + Y D + + +SFK G
Sbjct: 215 DSKICPSLCSYSGLN------GNPSSE-LDYCSTYRQHLDVPRDSPRAISFKNG 261
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 555 bits (1429), Expect = e-158
Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)
Query: 409 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 464
S R R+S P P L A P + D +P S++ +SS R
Sbjct: 773 SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 831
Query: 465 --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 522
+DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 832 ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 891
Query: 523 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 582
ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 892 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 951
Query: 583 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 642
DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 952 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 1011
Query: 643 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 702
IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 1012 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 1071
Query: 703 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 1072 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 483 bits (1244), Expect = e-136
Identities = 236/268 (88%), Positives = 240/268 (89%), Gaps = 2/268 (0%)
Query: 87 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 146
MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE
Sbjct: 1 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 60
Query: 147 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 206
EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT
Sbjct: 61 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 120
Query: 207 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 266
PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL
Sbjct: 121 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 180
Query: 267 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTPTPVPR 326
RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP L + + R
Sbjct: 181 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASL--YQSSIDR 238
Query: 327 EPGRKPLSSSRLGEVTGSPSPPPRSGAP 354
R S+S + P G P
Sbjct: 239 SLERPMSSASMASDFRKRRKSEPAVGPP 266
Score = 167 bits (424), Expect = 2e-41
Identities = 115/234 (49%), Positives = 129/234 (55%), Gaps = 37/234 (15%)
Query: 315 PPLPTTPTPVPREPGRKPLSSSRLGEV------TGSPSPPPRSGAPTPSSRAPALSPTR- 367
PP P + +PLS S SP PPP P P R S T
Sbjct: 131 PPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEK 190
Query: 368 ----PPKKPLD-------------YVQDHSSGVFNE--ASLYQSSIDRSLERPMSSASMA 408
PP + +D Y SS + +E ASLYQSSIDRSLERPMSSASMA
Sbjct: 191 HDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMA 250
Query: 409 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRE 468
SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK +
Sbjct: 251 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGD 310
Query: 469 SPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVY----DFKAQTSKELSFKKG 518
+ S + G + G P E L + Y D + + +SFK G
Sbjct: 311 DSKICPSLCSYSGLN------GNPSSE-LDYCSTYRQHLDVPRDSPRAISFKNG 357
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 409 bits (1052), Expect = e-114
Identities = 285/765 (37%), Positives = 394/765 (51%), Gaps = 125/765 (16%)
Query: 13 SSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQS 72
SSP R +S WR + + NG+A SSLAAKG+RSV PNL +S S
Sbjct: 53 SSPASPQETRQHESKPDEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS 109
Query: 73 QITVNGNSGGAVSPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYP 124
+ +S + + PS AY +N +IV+ Q S S
Sbjct: 110 PLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSE 169
Query: 125 QHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDR 179
+ D + P EKR V+K+ +DE GIP +R T +R
Sbjct: 170 RRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ER 226
Query: 180 PKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSH 239
KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P S P +K++ S+
Sbjct: 227 SKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SY 275
Query: 240 SDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIF 299
D + A+ P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+
Sbjct: 276 IDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIY 326
Query: 300 EYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTP--- 356
EY+PGKSS+L +E+ ++ + SP P + TP
Sbjct: 327 EYQPGKSSVLTNEK---------------------------MSSAISPTPEISSETPGYI 359
Query: 357 -SSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSID---------RSLERPMSSAS 406
SS A+ K+ D + + NE +Y+S ++ L+RP SSAS
Sbjct: 360 YSSNFHAV------KRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSAS 413
Query: 407 M-----------------ASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTL 449
+F +RR + + L DQ + D+
Sbjct: 414 TKDSESPRHFIPADYLESTEEFIRRRHDDKE----KLLADQRRLKREQEEADIAA----- 464
Query: 450 TKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQT 509
+ T P+ + L ++ +A R+ E PA+A +DFKAQT
Sbjct: 465 -RRHTGVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS----EMRPARAKFDFKAQT 514
Query: 510 SKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPG 569
KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q
Sbjct: 515 LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVL 573
Query: 570 EIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 629
E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K
Sbjct: 574 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 633
Query: 630 KN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPR 686
+ K DY D P S S S + Q+ T + Q + F QALY+Y P+
Sbjct: 634 RPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQ 693
Query: 687 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 694 NDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 406 bits (1043), Expect = e-113
Identities = 283/753 (37%), Positives = 391/753 (51%), Gaps = 127/753 (16%)
Query: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 84
P SA WR + + NG+A SSLAAKG+RSV PNL +S S + +S
Sbjct: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIG 162
Query: 85 SPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYPQHAQSLDGTTSS 136
+ + PS AY +N +IV+ Q S S + D +
Sbjct: 163 TDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ 222
Query: 137 SIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 191
P EKR V+K+ +DE GIP +R T +R KDWYKTMFKQI
Sbjct: 223 EKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQI 279
Query: 192 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 251
H +++ DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+
Sbjct: 280 HKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSAT 328
Query: 252 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 311
P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +
Sbjct: 329 LPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTN 379
Query: 312 ERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTP----SSRAPALSPTR 367
E+ ++ + SP P + TP SS A+
Sbjct: 380 EK---------------------------MSSAISPTPEISSETPGYIYSSNFHAV---- 408
Query: 368 PPKKPLDYVQDHSSGVFNEASLYQSSID---------RSLERPMSSASM----------- 407
K+ D + + NE +Y+S ++ L+RP SSAS
Sbjct: 409 --KRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIP 466
Query: 408 ------ASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSP 461
+F +RR + + L DQ + D+ + T P+
Sbjct: 467 ADYLESTEEFIRRRHDDKE----KLLADQRRLKREQEEADIAA------RRHTGVIPTHH 516
Query: 462 SRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTV 521
+ L ++ +A R+ E PA+A +DFKAQT KEL +KGD V
Sbjct: 517 QFITNERF-----GDLLNIDDTAKRKSGS----EMRPARAKFDFKAQTLKELPLQKGDIV 567
Query: 522 YILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFN 581
YI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN
Sbjct: 568 YIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFN 626
Query: 582 ADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPD 640
DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D
Sbjct: 627 GDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMD 686
Query: 641 PPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDV 698
P S S S + Q+ T + Q + F QALY+Y P+N+DELELR+ D+
Sbjct: 687 LPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDI 746
Query: 699 IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
+DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 747 VDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 399 bits (1024), Expect = e-111
Identities = 295/850 (34%), Positives = 417/850 (49%), Gaps = 197/850 (23%)
Query: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 84
P SA WR + + NG+A SSLAAKG+RSV PNL +S + + G+
Sbjct: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSF 162
Query: 85 SPMSYYQRPFSPSAYSLPAS------LNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSI 138
+P+S FSP +P + ++ + +S DS+ + + SL GT S +
Sbjct: 163 APISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAF 222
Query: 139 P---------------------LYRSSEEEKRVTVI------------------KAPHYP 159
P L + E++KR++ + + P P
Sbjct: 223 PSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSP 282
Query: 160 GIG----------------------PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP 197
G +DE GIP +R T +R KDWYKTMFKQIH +++
Sbjct: 283 GKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR- 338
Query: 198 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 257
DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 339 DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPAR 388
Query: 258 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPP-P 316
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 389 SSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRD 439
Query: 317 LPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR----------SGAPTPSSRAPALSPT 366
+ + EP K S G+ PPP+ S P ++ A+SPT
Sbjct: 440 ISPEEIDLKNEPWYKFFSELEFGK------PPPKKIWDYTPGDCSILPREDRKSSAISPT 493
Query: 367 ----------------RPPKKPLDYVQDHSSGVFNEASLYQSSID---------RSLERP 401
K+ D + + NE +Y+S ++ L+RP
Sbjct: 494 PEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRP 553
Query: 402 MSSASM-----------------ASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPG 444
SSAS +F +RR + + L DQ + D+
Sbjct: 554 SSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKE----KLLADQRRLKREQEEADIAA 609
Query: 445 SSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYD 504
+ T P+ + L ++ +A R+ E PA+A +D
Sbjct: 610 ------RRHTGVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS----EMRPARAKFD 654
Query: 505 FKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPP 564
FKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P
Sbjct: 655 FKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP 714
Query: 565 PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSY 624
Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++Y
Sbjct: 715 -VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITY 773
Query: 625 VEVVKKN-TKGAEDYPDPPIPHSYSSDRI-------HSLSSN-------------KPQRP 663
V+V+K+ K DY D P S S HSL + + Q+
Sbjct: 774 VDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQR 833
Query: 664 VFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFG 721
T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FG
Sbjct: 834 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG 893
Query: 722 TFPGNYVKRL 731
TFPGNYVK L
Sbjct: 894 TFPGNYVKPL 903
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 384 bits (986), Expect = e-106
Identities = 274/740 (37%), Positives = 374/740 (50%), Gaps = 131/740 (17%)
Query: 13 SSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQS 72
SSP R +S WR + + NG+A SSLAAKG+RSV PNL +S S
Sbjct: 53 SSPASPQETRQHESKPDEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS 109
Query: 73 QITVNGNSGGAVSPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYP 124
+ +S + + PS AY +N +IV+ Q S S
Sbjct: 110 PLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSE 169
Query: 125 QHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDR 179
+ D + P EKR V+K+ +DE GIP +R T +R
Sbjct: 170 RRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ER 226
Query: 180 PKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSH 239
KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P S P +K++ S+
Sbjct: 227 SKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SY 275
Query: 240 SDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIF 299
D + A+ P+P +SS+E++DW+PPD+KVDTR
Sbjct: 276 IDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPPDKKVDTR---------- 316
Query: 300 EYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTP--- 356
+Y SI +++ PG+ + ++ +++ + SP P + TP
Sbjct: 317 KYRAEPKSIYEYQ---------------PGKSSVLTNE--KMSSAISPTPEISSETPGYI 359
Query: 357 -SSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR 415
SS A+ K+ D + + NE +Y+S ++
Sbjct: 360 YSSNFHAV------KRESDGAPGDLTSLENERQIYKSVLEG------------------- 394
Query: 416 KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSS 475
G + L G S PSS + KD ESPR +
Sbjct: 395 ----------------------GDIPLQGLSGL-------KRPSSSASTKDSESPRHFIP 425
Query: 476 TLTDMGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG 534
D S RR +KE PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEG
Sbjct: 426 A--DYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG 483
Query: 535 EHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGD 594
EHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+
Sbjct: 484 EHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGE 542
Query: 595 RVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIH 653
R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 543 RITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATA 602
Query: 654 SLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFV 711
S + Q+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFV
Sbjct: 603 SPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 662
Query: 712 GTSRRTKFFGTFPGNYVKRL 731
GTSRRTK FGTFPGNYVK L
Sbjct: 663 GTSRRTKQFGTFPGNYVKPL 682
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 357 bits (916), Expect = 2e-98
Identities = 257/697 (36%), Positives = 350/697 (50%), Gaps = 129/697 (18%)
Query: 57 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 111
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 225 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 284
Query: 112 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 162
Q S S + D + P EKR V+K+
Sbjct: 285 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 344
Query: 163 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQ 222
+DE GIP +R T +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P
Sbjct: 345 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----L 396
Query: 223 SHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPP 282
S P +K++ S+ D + A+ P+P +SS+E++DW+PP
Sbjct: 397 SVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPP 441
Query: 283 DRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVT 342
D+KVDTR +Y SI +++ PG+ + ++ +++
Sbjct: 442 DKKVDTR----------KYRAEPKSIYEYQ---------------PGKSSVLTNE--KMS 474
Query: 343 GSPSPPPRSGAPTP----SSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSL 398
+ SP P + TP SS A+ K+ D + + NE +Y+S ++
Sbjct: 475 SAISPTPEISSETPGYIYSSNFHAV------KRESDGAPGDLTSLENERQIYKSVLEG-- 526
Query: 399 ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 458
G + L G S P
Sbjct: 527 ---------------------------------------GDIPLQGLSGL-------KRP 540
Query: 459 SSPSRAKDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKK 517
SS + KD ESPR + D S RR +KE PA+A +DFKAQT KEL +K
Sbjct: 541 SSSASTKDSESPRHFIPA--DYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQK 598
Query: 518 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK 577
GD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK
Sbjct: 599 GDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAK 657
Query: 578 YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAE 636
+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K
Sbjct: 658 FNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPV 717
Query: 637 DYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELR 694
DY D P S S S + Q+ T + Q + F QALY+Y P+N+DELELR
Sbjct: 718 DYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELR 777
Query: 695 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 778 DGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 280 bits (715), Expect = 4e-75
Identities = 232/714 (32%), Positives = 324/714 (45%), Gaps = 145/714 (20%)
Query: 57 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 111
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 257 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 316
Query: 112 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 162
Q S S + D + P EKR V+K+
Sbjct: 317 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 376
Query: 163 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQ 222
+DE GIP +R T +R KDWYKTMFKQIH +++ + + Y Y + S +
Sbjct: 377 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEE 433
Query: 223 SHPAAKTQTY---RPLSKSHSDNSP------NAFKDASSPVPPPHVPP------------ 261
+P T + P KS D+S + +D SP+ P
Sbjct: 434 DNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVK 493
Query: 262 -----PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER--- 313
P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 494 RSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSR 553
Query: 314 -------------------------PPP------LPTTPTPVPREPGRKPLSSS------ 336
PPP P + +PRE + L
Sbjct: 554 DISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQT 613
Query: 337 -------RLGEVTGSPSPP-PRSGA--PTP--SSRAPAL---SPTRPPKKPLDYVQDHSS 381
++ + +PS P+S A PTP SS P S K+ D +
Sbjct: 614 ELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 673
Query: 382 GVFNEASLYQSSID---------RSLERPMSSASM-----------------ASDFRKRR 415
+ NE +Y+S ++ L+RP SSAS +F +RR
Sbjct: 674 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR 733
Query: 416 KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSS 475
+ + L DQ + D+ + T P+ +
Sbjct: 734 HDDKE----KLLADQRRLKREQEEADIAA------RRHTGVIPTHHQFITNERF-----G 778
Query: 476 TLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE 535
L ++ +A R+ E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGE
Sbjct: 779 DLLNIDDTAKRKSGS----EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE 834
Query: 536 HHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR 595
HHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R
Sbjct: 835 HHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGER 893
Query: 596 VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYS 648
+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 894 ITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPS 947
Score = 102 bits (254), Expect = 1e-21
Identities = 44/55 (80%), Positives = 51/55 (92%)
Query: 677 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
+QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 53.1 bits (126), Expect = 9e-07
Identities = 74/296 (25%), Positives = 111/296 (37%), Gaps = 48/296 (16%)
Query: 303 PGKSSILQHERPPPLPTTPT----PVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSS 358
PG+ S+ PPLP + P P S L ++ S P PRS A +
Sbjct: 996 PGRRSLALTPPLPPLPEASIYNTDHLALSPRASPSLSLSLPHLSWSDRPTPRSVASPLAL 1055
Query: 359 RAP----ALSPTRPPKKPLDY---VQDHSSGVFNEASLY-----QSSIDRSLERPMSSAS 406
+P +L+PT ++ V SSG+ ++ L S+ L SS S
Sbjct: 1056 PSPHKTYSLAPTSQASLHMNGDGGVHTPSSGIHQDSFLQLPLGSSDSVISQLSDAFSSQS 1115
Query: 407 MASDFRKR-----RKSEPAVGPPRGLGDQSASRTS---PGRVDLPGSSTTLTKSFTSSSP 458
+R+ RK+E G RG G S+ S P V S+ +
Sbjct: 1116 KRQPWREESGQYERKAERGAGE-RGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEE 1174
Query: 459 SSPSRAKDRESPRSYSSTLT------DMGRSAPR----------ERRGTPEKEKLPA--- 499
S P + P S + GR A R +RR TP++ +
Sbjct: 1175 SRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLF 1234
Query: 500 --KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 551
+A+Y + Q EL + GD V ++ K D W+ G + G FP +YV+ L
Sbjct: 1235 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 36.2 bits (82), Expect = 0.11
Identities = 22/44 (50%), Positives = 27/44 (61%), Gaps = 5/44 (11%)
Query: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRS 68
P SA WR + + NG+A SSLAAKG+RSV PNL +S
Sbjct: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKS 146
Score = 30.8 bits (68), Expect = 4.7
Identities = 61/284 (21%), Positives = 97/284 (34%), Gaps = 43/284 (15%)
Query: 223 SHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPP 282
S PA + ++ P+S++ SP PPP+ P P D + D
Sbjct: 222 SQPARASGSFAPISQTPPSFSP---------------PPPLVPPAPEDLRRVSEPDLTGA 266
Query: 283 DRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTT----PTPVPREPGRK------- 331
D+ +E S ++ + P+T PT V + R+
Sbjct: 267 VSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSS 326
Query: 332 ---PLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEAS 388
P+S R+GE +P+ PT +A ++ + QD S +E
Sbjct: 327 LSDPVSERRVGEQDSAPT----QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVG 382
Query: 389 LYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGP--PRGLGDQSASRTSPGRVDLPGSS 446
+ + +RS + +M K + P P P + D P
Sbjct: 383 IPLRNTERSKD---WYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEEDNP--- 436
Query: 447 TTLTKSFTSSSPSSPSRAKDRE--SPRSYSSTLTDMGRSAPRER 488
T T F +S+PS S D + SPR S T S PR +
Sbjct: 437 YTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSK 480
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 276 bits (706), Expect = 5e-74
Identities = 211/661 (31%), Positives = 292/661 (44%), Gaps = 147/661 (22%)
Query: 125 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY 184
QH Q+ T + S +KR Y GIGPVDESG+P A R++VDRP+DWY
Sbjct: 98 QHTQNWSATWTKD-----SKRRDKRWV-----KYEGIGPVDESGMPIAPRSSVDRPRDWY 147
Query: 185 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPY-SAQSHPAAKTQTYRPLSKSHSDNS 243
+ MF+QIH PD D +T+ +P + AQ PA
Sbjct: 148 RRMFQQIHR-KMPDLQLD-----WTFEEPPRDPRHLGAQQRPAH---------------- 185
Query: 244 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEP 303
RP +S+ WD + PRS F Y P
Sbjct: 186 -----------------------RPGPATSSSGRSWDHSEEL---------PRSTFNYRP 213
Query: 304 GK-SSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPA 362
G S++LQ P+ RE + + R P
Sbjct: 214 GAFSTVLQ-------PSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDD---- 262
Query: 363 LSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVG 422
P P +P++ + + E S R++E + S + R+ + P G
Sbjct: 263 --PGEKPSQPIEVLLERELA---ELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAG 317
Query: 423 PPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGR 482
P SA +S GS+ +L+ + S +D P S G
Sbjct: 318 PA------SAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGG 371
Query: 483 SAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGI 542
+P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+NW EGEHHGR+GI
Sbjct: 372 GSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGI 428
Query: 543 FPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRV 602
FP +YVE L E +P + PP Q E GEA+A+Y F D VELS RKG+ + L+++V
Sbjct: 429 FPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKV 487
Query: 603 DQNWYEGKIPGTNRQGIFPVSYVEVVK-----------------KNTKGAEDYPDPPIPH 645
++NWYEG+I GT RQGIFP SYV+V + + T A P P
Sbjct: 488 NENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS 547
Query: 646 SYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG-------------------- 674
+ S D I P+R F+ +N+ G
Sbjct: 548 ALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSP 607
Query: 675 -------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNY 727
P++A+Y Y P+NEDELELRE D +DVM++CDDGWFVG SRRT+ FGTFPGNY
Sbjct: 608 NTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNY 667
Query: 728 V 728
V
Sbjct: 668 V 668
Score = 69.7 bits (169), Expect = 9e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 547 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 606
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 358 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 417
Query: 607 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 666
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 418 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 452
Query: 667 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 726
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 453 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 508
Query: 727 YVK 729
YV+
Sbjct: 509 YVQ 511
Score = 42.4 bits (98), Expect = 0.002
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 576 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 628
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 256 bits (653), Expect = 7e-68
Identities = 189/560 (33%), Positives = 273/560 (48%), Gaps = 121/560 (21%)
Query: 198 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 257
DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 476 DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPAR 525
Query: 258 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER---- 313
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 526 SSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRD 576
Query: 314 ------------------------PPP------LPTTPTPVPREPGRKPLSSS------- 336
PPP P + +PRE + L
Sbjct: 577 ISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTE 636
Query: 337 ------RLGEVTGSPSPP-PRSGA--PTP--SSRAPAL---SPTRPPKKPLDYVQDHSSG 382
++ + +PS P+S A PTP SS P S K+ D +
Sbjct: 637 LEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTS 696
Query: 383 VFNEASLYQSSID---------RSLERPMSSASM-----------------ASDFRKRRK 416
+ NE +Y+S ++ L+RP SSAS +F +RR
Sbjct: 697 LENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRH 756
Query: 417 SEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSST 476
+ + L DQ + D+ + T P+ +
Sbjct: 757 DDKE----KLLADQRRLKREQEEADIAA------RRHTGVIPTHHQFITNERF-----GD 801
Query: 477 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 536
L ++ +A R+ E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEH
Sbjct: 802 LLNIDDTAKRKSGS----EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH 857
Query: 537 HGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRV 596
HGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+
Sbjct: 858 HGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERI 916
Query: 597 ILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSL 655
LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S S
Sbjct: 917 TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASP 976
Query: 656 SSNKPQRPVFTHENIQGGGE 675
+ + + + +G GE
Sbjct: 977 QPWREESGQYERKAERGAGE 996
Score = 154 bits (390), Expect = 2e-37
Identities = 196/765 (25%), Positives = 295/765 (38%), Gaps = 169/765 (22%)
Query: 57 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 111
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 257 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 316
Query: 112 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 162
Q S S + D + P EKR V+K+
Sbjct: 317 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 376
Query: 163 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPY-------------- 208
+DE GIP +R T +R KDWYKTMFKQIH +++ + + Y Y
Sbjct: 377 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEE 433
Query: 209 TYNAGLYNPPYSA--------------QSHPAAKTQTYRPLSKSHSD-NSP--NAFKDAS 251
T + + +P S+P + SD SP + +D
Sbjct: 434 TKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSDLYSPRYSFSEDTK 493
Query: 252 SPVPPPH-----------------VPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSE 294
SP+ P P+P +SS+E++DW+PPD+KVDTRK+R+E
Sbjct: 494 SPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE 553
Query: 295 PRSIFEYEPGKSSILQHER-PPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR--- 350
P+SI+EY+PGKSS+L +E+ + + EP K S G+ PPP+
Sbjct: 554 PKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGK------PPPKKIW 607
Query: 351 SGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLER---------- 400
P S P +D + + + SL Q+ ++ LE+
Sbjct: 608 DYTPGDCSILPR--------------EDRKTNLDKDLSLCQTELEADLEKMETLNKAPSA 653
Query: 401 --PMSSA--------------SMASDFRK-RRKSEPAVGPPRGLGDQSASRTSPGRVDLP 443
P SSA +S+F +R+S+ A G L ++ S L
Sbjct: 654 NVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSV----LE 709
Query: 444 GSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVY 503
G L PSS + KD ESPR + + + RR +KEKL A
Sbjct: 710 GGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA-DYLESTEEFIRRRHDDKEKLLADQRR 768
Query: 504 DFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPP 563
+ Q +++ ++ V + E G + I K + +PAR
Sbjct: 769 LKREQEEADIAARRHTGVI---PTHHQFITNERFG--DLLNIDDTAKRKSGSEMRPAR-- 821
Query: 564 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 623
AK++F A T EL L+KGD V + K++DQNWYEG+ G R GIFP +
Sbjct: 822 ------------AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRT 867
Query: 624 YVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNY 683
Y+E++ PP + K Q T + GE A +N+
Sbjct: 868 YIELL------------PP--------------AEKAQPKKLTPVQVLEYGEAI-AKFNF 900
Query: 684 TPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 728
+ E+ R+ + I ++ + D+ W+ G T G FP YV
Sbjct: 901 NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 945
Score = 148 bits (373), Expect = 2e-35
Identities = 105/298 (35%), Positives = 146/298 (48%), Gaps = 49/298 (16%)
Query: 470 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 529
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 865 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 924
Query: 530 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPP------ 564
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 925 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
Query: 565 ---------PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 615
+ G G I+K + ++V L R+ D N E PG
Sbjct: 985 QYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLS-----DLNTPEESRPGKP 1039
Query: 616 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 675
FP S E +++ G + ++ R S QR V T + Q +
Sbjct: 1040 LGSAFPGSEAEQTERHRGGEQ-------AGRKAARRGGSQQPQAQQRRV-TPDRSQTSQD 1091
Query: 676 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1092 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
Score = 36.2 bits (82), Expect = 0.11
Identities = 22/44 (50%), Positives = 27/44 (61%), Gaps = 5/44 (11%)
Query: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRS 68
P SA WR + + NG+A SSLAAKG+RSV PNL +S
Sbjct: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKS 146
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 228 bits (582), Expect = 1e-59
Identities = 131/319 (41%), Positives = 175/319 (54%), Gaps = 59/319 (18%)
Query: 465 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 524
+D P S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI
Sbjct: 12 RDFVYPSSTRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIH 68
Query: 525 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADT 584
+++D+NW EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D
Sbjct: 69 KEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDL 127
Query: 585 NVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK--------------- 629
VELS RKG+ + L+++V++NWYEG+I GT RQGIFP SYV+V +
Sbjct: 128 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPT 187
Query: 630 --KNTKGAEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG-- 674
+ T A P P + S D I P+R F+ +N+ G
Sbjct: 188 SPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPA 247
Query: 675 -------------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGW 709
P++A+Y Y P+NEDELELRE D +DVM++CDDGW
Sbjct: 248 LSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGW 307
Query: 710 FVGTSRRTKFFGTFPGNYV 728
FVG SRRT+ FGTFPGNYV
Sbjct: 308 FVGVSRRTQKFGTFPGNYV 326
Score = 69.7 bits (169), Expect = 9e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 547 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 606
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 16 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 75
Query: 607 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 666
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 76 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 110
Query: 667 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 726
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 111 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 166
Query: 727 YVK 729
YV+
Sbjct: 167 YVQ 169
Score = 45.4 bits (106), Expect = 2e-04
Identities = 33/126 (26%), Positives = 60/126 (47%), Gaps = 12/126 (9%)
Query: 431 SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR---SYS---STLTDMGRSA 484
SA R+ +DL G ++ F+ + + ++ +P S+S S D+G S+
Sbjct: 205 SALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSS 264
Query: 485 PRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGI 542
P T + P +A+Y ++ Q EL ++GD V ++++ D W+ G + G
Sbjct: 265 PN----TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGT 320
Query: 543 FPISYV 548
FP +YV
Sbjct: 321 FPGNYV 326
Score = 42.4 bits (98), Expect = 0.002
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 576 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 628
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 117 bits (294), Expect = 3e-26
Identities = 115/477 (24%), Positives = 196/477 (41%), Gaps = 73/477 (15%)
Query: 302 EPGKSSILQHERPPPLP----------TTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR- 350
+PGK + PPPLP T + + L S+ G+ G PPR
Sbjct: 264 KPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRL 323
Query: 351 -----SGAPTPSSRAPA-LSPTRPPKKPLDYVQDHSSGV-FNEASLYQSSIDRSLERPMS 403
+G P+ + P + P RPP L + + + FN +SS D L++ S
Sbjct: 324 PPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQS 378
Query: 404 SASMASDFRKRR--KSEPAVGPPR-----------------GLGDQSASRTSPGRVDLPG 444
+ + K + K++ V PPR G+ ++ +PG +
Sbjct: 379 NLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKR 438
Query: 445 SSTTLTKSFTSSSPSSPSRAKDRESPR-SYSSTLTDMGRSAPRERRGTPEKEKLP----- 498
+ T ++ + +D S +T + R R P + P
Sbjct: 439 GDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL-RSRPNDPSHAQKPVDSGA 497
Query: 499 --AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PE 555
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 498 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 557
Query: 556 KAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 615
R + + +A++ + + ELS +G+ +IL + V++ W G++ G
Sbjct: 558 GGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG-- 615
Query: 616 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 675
R GIFP+++VE V EDYP S + S + + N Q
Sbjct: 616 RTGIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSL 661
Query: 676 P---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729
P +AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 662 PAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 716
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 497 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 553
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
Query: 554 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 613
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 721 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 774
Query: 614 TNRQGIFPVSYVEVVK 629
+ GIFP +Y++ ++
Sbjct: 775 --KSGIFPKNYIQFLQ 788
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 114 bits (284), Expect = 4e-25
Identities = 116/456 (25%), Positives = 192/456 (42%), Gaps = 54/456 (11%)
Query: 302 EPGKSSILQHERPPPLP----------TTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR- 350
+PGK + PPPLP T + + L S+ G+ G PPR
Sbjct: 264 KPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRL 323
Query: 351 -----SGAPTPSSRAPA-LSPTRPPKKPLDYVQDHSSGV-FNEASLYQSSIDRSLERPMS 403
+G P+ + P + P RPP L + + + FN +SS D L++ S
Sbjct: 324 PPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQS 378
Query: 404 SASMASDFRKRR--KSEPAVGPPRGL-GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSS 460
+ + K + K++ V PPR G S+ G V + T++
Sbjct: 379 NLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLV---MLKQTENNYLECQKG 435
Query: 461 PSRAKDRESPRSYSSTLTDMGRSAPRE--RRGTPEKEKLP-AKAVYDFKAQTSKELSFKK 517
+ S + L + RS P + P P A ++DF A+ +L+
Sbjct: 436 EDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTS 495
Query: 518 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIA 576
G+ VY+L KID +WY G ++GIFP +YV+ + PE R + + +A
Sbjct: 496 GEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVA 555
Query: 577 KYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAE 636
++ + + ELS +G+ +IL + V++ W G++ G R GIFP+++VE V E
Sbjct: 556 RFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPLNFVEPV-------E 606
Query: 637 DYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDELEL 693
DYP S + S + + N Q P +AL+++T D+L
Sbjct: 607 DYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSF 659
Query: 694 RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729
+ D I ++E+ D W G + + G FP +V+
Sbjct: 660 KRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 693
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 497 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 553
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
Query: 554 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 613
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 698 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 751
Query: 614 TNRQGIFPVSYVEVVK 629
+ GIFP +Y++ ++
Sbjct: 752 --KSGIFPKNYIQFLQ 765
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 113 bits (282), Expect = 7e-25
Identities = 139/557 (24%), Positives = 222/557 (39%), Gaps = 74/557 (13%)
Query: 220 SAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPV---------------P 264
S+ S T RPL S +S N S+P+ P VPP + P
Sbjct: 128 SSDSGKKVPTPAPRPLLLKKSVSSENPTYP-SAPLKPVTVPPRLAGASQAKAYKSLGEGP 186
Query: 265 PLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQ-HE---RPPPLP-- 318
P P K D D + ++ E G +L HE PPPLP
Sbjct: 187 PANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLGLHEDPQSPPPLPAE 246
Query: 319 --------TTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR------SGAPTPSSRAPA-L 363
T + + L S+ G+ G PPR +G P+ + P +
Sbjct: 247 KPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKV 306
Query: 364 SPTRPPKKPLDYVQDHSSGV-FNEASLYQSSIDRSLERPMSSASMASDFRKRR--KSEPA 420
P RPP L + + + FN +SS D L++ S+ + K + K++
Sbjct: 307 PPERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQSNLATGLSKAKSQVFKNQDP 361
Query: 421 VGPPRGL-GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTD 479
V PPR G S+ G V + T++ + S + L +
Sbjct: 362 VLPPRPKPGHPLYSKYMRGDVLV---MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDE 418
Query: 480 MGRSAPRE--RRGTPEKEKLP-AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 536
RS P + P P A ++DF A+ +L+ G+ VY+L KID +WY G
Sbjct: 419 HLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC 478
Query: 537 HGRVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR 595
++GIFP +YV+ + PE R + + +A++ + + ELS +G+
Sbjct: 479 RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEI 538
Query: 596 VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL 655
+IL + V++ W G++ G R GIFP+++VE V EDYP S + S
Sbjct: 539 IILKEYVNEEWARGEVRG--RTGIFPLNFVEPV-------EDYPT-------SGANVLST 582
Query: 656 SSNKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVG 712
+ + N Q P +AL+++T D+L + D I ++E+ D W G
Sbjct: 583 KVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG 642
Query: 713 TSRRTKFFGTFPGNYVK 729
+ + G FP +V+
Sbjct: 643 RLQDRE--GIFPAVFVR 657
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 497 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 553
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
Query: 554 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 613
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 662 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 715
Query: 614 TNRQGIFPVSYVEVVK 629
+ GIFP +Y++ ++
Sbjct: 716 --KSGIFPKNYIQFLQ 729
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 95.5 bits (236), Expect = 2e-19
Identities = 66/206 (32%), Positives = 106/206 (51%), Gaps = 26/206 (12%)
Query: 444 GSSTTLTKSFTS-SSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLP---- 498
GS T T + S SS + +KD +S + G PR + +P +P
Sbjct: 88 GSGTNCTNALRSQSSTVANCSSKDLQSSQ---------GGQQPRVQSWSPPVRGIPQLPC 138
Query: 499 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 558
AKA+Y+++ + +L F KGD + + R++D+NWY GE +G G FP ++V+ + P
Sbjct: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKP----- 193
Query: 559 PARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 618
P PP Q + + K + AD + L K D + +++RVD+NW EG + ++ G
Sbjct: 194 --LPQPPPQCKALYDFEVK-DKEADKDC-LPFAKDDVLTVIRRVDENWAEGML--ADKIG 247
Query: 619 IFPVSYVEVVKKNTKGAEDYPDPPIP 644
IFP+SYVE K ++ PP+P
Sbjct: 248 IFPISYVE-FNSAAKQLIEWDKPPVP 272
Score = 72.0 bits (175), Expect = 2e-12
Identities = 31/52 (59%), Positives = 37/52 (71%)
Query: 677 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 728
+ A+Y YTPR EDELELR+ ++ V E+C DGWF GTS T G FPGNYV
Sbjct: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
Score = 55.8 bits (133), Expect = 1e-07
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 675 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
E + + +Y P++E ELEL+E D++ V +K +DGWF GT +R G FPG++V+ +
Sbjct: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Score = 49.7 bits (117), Expect = 1e-05
Identities = 70/276 (25%), Positives = 103/276 (37%), Gaps = 61/276 (22%)
Query: 320 TPTPVPREPGRK-------------PLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPT 366
+P P P PG PL+ + +T SPS S PS R + P
Sbjct: 630 SPQPAPLMPGSATHTAAISISRASAPLACAAAAPLT-SPSITSASLEAEPSGRIVTVLPG 688
Query: 367 RPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERP--MSSASMASDFRKRRKSEPA---- 420
P D +S +S + D E+ + S AS RK R S PA
Sbjct: 689 LPTSP------DSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTL 742
Query: 421 --------------VGP--PRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRA 464
VGP P G G R VD G TT + + +A
Sbjct: 743 EVELGSAELPLQGAVGPELPPGGGH---GRAGSCPVDGDGPVTTAVAGAALAQDAFHRKA 799
Query: 465 KDRES-------PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 517
+S PR S+L G R E+ ++ V + Q+ EL K+
Sbjct: 800 SSLDSAVPIAPPPRQACSSL---GPVLNESRPVVCERHRV----VVSYPPQSEAELELKE 852
Query: 518 GDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 551
GD V++ +K + W++G + +G+ G+FP S+VE +
Sbjct: 853 GDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Score = 44.7 bits (104), Expect = 3e-04
Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 575 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 634
+A Y + EL LRKG+ ++ +R W++G T++ G+FP +YV V T+
Sbjct: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV---TRA 507
Query: 635 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 674
+ +P S + ++ P + +QG G
Sbjct: 508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
Score = 44.7 bits (104), Expect = 3e-04
Identities = 48/216 (22%), Positives = 85/216 (39%), Gaps = 46/216 (21%)
Query: 442 LPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM-GRSAPRERRGTPEKEKLPAK 500
LPG T+ S +S+ +S + D++S + L + G S R+ R +P PA
Sbjct: 686 LPGLPTS-PDSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSP-----PAS 739
Query: 501 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPI--------------- 545
+ + S EL + + G HGR G P+
Sbjct: 740 PTLEVELG-SAELPLQGA--------VGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAAL 790
Query: 546 ---SYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK------------YNFNADTNVELSL 590
++ K + + A P PPP +G + + ++ + EL L
Sbjct: 791 AQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELEL 850
Query: 591 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 626
++GD V + K+ + W++G + + G+FP S+VE
Sbjct: 851 KEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 40.0 bits (92), Expect = 0.008
Identities = 62/300 (20%), Positives = 106/300 (35%), Gaps = 71/300 (23%)
Query: 261 PPVPPLRPRDRSSTEKHDWDPP---DRKVDTRKFRSEPRSIFEYEPGKSSILQH--ERPP 315
PPVP + + SS P D K +T+K S + ++S +H E P
Sbjct: 269 PPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISP 328
Query: 316 PLPTTPTPVPREPGRKPLSSSRLGEVTG-SPSPPPRSGAPTPSSRAPALSPTRPPKKPLD 374
P+ + + P +++R+ E++G S S P + T L T PP P
Sbjct: 329 PVLISSS--------NPTAAARISELSGLSCSAPSQVHISTTG-----LIVTPPPSSP-- 373
Query: 375 YVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASR 434
V S F YQ+++ P + PP L +
Sbjct: 374 -VTTGPSFTFPSDVPYQAALGTL--------------------NPPLPPPPLLAATVLAS 412
Query: 435 TSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK 494
T PG ++ + A PR + + + P+ R
Sbjct: 413 TPPG--------------------ATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSV--- 449
Query: 495 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLT 552
A+Y + + EL +KG+ + + W++G H ++G+FP +YV +T
Sbjct: 450 ----YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
Score = 34.7 bits (78), Expect = 0.32
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 678 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729
+ALYNY + +L+ + D+I + + D+ W+ G G FP N+V+
Sbjct: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHG--EVNGIHGFFPTNFVQ 189
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 90.9 bits (224), Expect = 4e-18
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%)
Query: 500 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 549
KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE
Sbjct: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
Query: 550 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 604
+L +K PA P+ G + ++ V R+ D K+
Sbjct: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381
Query: 605 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 659
+ ++R + + V + + + A D + H + +SS+
Sbjct: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439
Query: 660 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 707
P GE + ALY Y P+ DELEL + ++ V+EKC D
Sbjct: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499
Query: 708 GWFVGTSRRTKFFGTFPGNYV 728
GWF G S RT G FPGNYV
Sbjct: 500 GWFKGASLRTGVSGVFPGNYV 520
Score = 89.7 bits (221), Expect = 8e-18
Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%)
Query: 412 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 465
R R + P PP R + QSA+ T G PGS L+ + S++ S A
Sbjct: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183
Query: 466 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 525
R +P + + L G KA+Y ++ + +L F KGD + + R
Sbjct: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225
Query: 526 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 585
K+D+ WY GE HG G P SY++ + P A P + A Y+F
Sbjct: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272
Query: 586 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 641
+ L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D
Sbjct: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328
Query: 642 PIPHSYSS 649
P P + SS
Sbjct: 329 PCPAAASS 336
Score = 54.7 bits (130), Expect = 3e-07
Identities = 22/55 (40%), Positives = 39/55 (70%)
Query: 675 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729
E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+
Sbjct: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 52.8 bits (125), Expect = 1e-06
Identities = 62/276 (22%), Positives = 101/276 (36%), Gaps = 41/276 (14%)
Query: 307 SILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTG---SPSPP----PRSGAPTPSSR 359
S Q + P +P P R P +S R V S PP PR P S+
Sbjct: 613 SAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAA 672
Query: 360 APALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSI---DRSLERPMSSASM-----ASDF 411
+ P GV + +S + ++ E+ + + +
Sbjct: 673 SAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGAST 732
Query: 412 RKRRKSEPAVGPPR------------GLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPS 459
+K+ +S P+V P +G + +S + GR S + +
Sbjct: 733 KKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRA----GSCPIESEMQGAMGM 788
Query: 460 SPSRAKDRESPRSYSSTLTDMGRSAPRERRGT-PEKEKLPA---KAVYDFKAQTSKELSF 515
P K S T R AP PE + LP + V + Q+ E+
Sbjct: 789 EPLHRK----AGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIEL 844
Query: 516 KKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVE 549
K+GD V++ +K + WY+G + +GR G+FP S+VE
Sbjct: 845 KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 51.2 bits (121), Expect = 3e-06
Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%)
Query: 454 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 500
+SS P + +R D ++ S ST T + R+A +GTP K +LP
Sbjct: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469
Query: 501 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 557
A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP +
Sbjct: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526
Query: 558 QPARPPPPAQPGEIGEAIAK 577
PP G +AK
Sbjct: 527 PAGGAGPPRNNVVGGSPLAK 546
Score = 48.5 bits (114), Expect = 2e-05
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 533 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 582
E E G +G+ P+ S T P + P RP P P E + Y +
Sbjct: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838
Query: 583 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 626
+ +EL ++GD V + K+ + WY+G + R G+FP S+VE
Sbjct: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 39.7 bits (91), Expect = 0.010
Identities = 21/76 (27%), Positives = 34/76 (44%)
Query: 564 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 623
PP + +A Y + + EL L KG+ +L++ W++G T G+FP +
Sbjct: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518
Query: 624 YVEVVKKNTKGAEDYP 639
YV V + G P
Sbjct: 519 YVTPVSRVPAGGAGPP 534
Score = 34.3 bits (77), Expect = 0.42
Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 678 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729
+ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 87.8 bits (216), Expect = 3e-17
Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 33/243 (13%)
Query: 505 FKAQTSKELSFKKGDTVYILRKID-QNWYEGEHHGRVGIFPISYVEKLTPP--------- 554
++AQ ELS GD V +R + + W GE GR G+FP V+++
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 555 -----EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEG 609
+ PA+ P P + ++ ++++ + EL L+ G+ V ++K ++ W+ G
Sbjct: 69 PRCARRRGHPAKHPRPQRWCKVN-----FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123
Query: 610 KIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI--PHSYSSDRIHSLSSNKPQRPVFTH 667
K G + G FP ++VE++ + PD P P ++ SL+ + P + T
Sbjct: 124 KKNG--QLGAFPSNFVELLDSGPPSLGN-PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
Query: 668 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPG 725
+ E ++ L++Y P DEL LR DV+ V+ K D GW+ G + + G FP
Sbjct: 181 SH----PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPD 234
Query: 726 NYV 728
N+V
Sbjct: 235 NFV 237
Score = 72.0 bits (175), Expect = 2e-12
Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 30/166 (18%)
Query: 488 RRGTPEKEKLP---AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 544
RRG P K P K + + + + EL + G+ V ++++I+ W+ G+ +G++G FP
Sbjct: 74 RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
Query: 545 ISYVEKLT--PPEKAQPARP---PPPAQPGEIGEAI------------------AKYNFN 581
++VE L PP P P P P +P ++ +++
Sbjct: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
Query: 582 ADTNVELSLRKGDRVILLKRV--DQNWYEGKIPGTNRQGIFPVSYV 625
+ EL+LR+GD V +L + D+ W+EG+ G R+G+FP ++V
Sbjct: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFV 237
Score = 59.7 bits (143), Expect = 9e-09
Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 22/160 (13%)
Query: 573 EAIAKYNFNADTNVELSLRKGDRVILLKRVD-QNWYEGKIPGTNRQGIFPVSYVEVVKKN 631
E + + A ELSL GD V ++ V + W G+ G R G+FP V+ + +
Sbjct: 2 EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
Query: 632 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDEL 691
+G+ + P R H +PQR + ++Y+P DEL
Sbjct: 60 LRGSGEARRPRCARR----RGHPAKHPRPQRWCKVN-------------FSYSPEQADEL 102
Query: 692 ELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
+L+ ++++++++ +DGW++G ++ G FP N+V+ L
Sbjct: 103 KLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
Score = 50.1 bits (118), Expect = 7e-06
Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 7/107 (6%)
Query: 457 SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFK 516
+P PS + + P SS D +P + T ++ + ++D++ + EL+ +
Sbjct: 149 NPDMPSVSPGPQRPPKLSSLAYD----SPPDYLQTVSHPEV-YRVLFDYQPEAPDELALR 203
Query: 517 KGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR 561
+GD V +L K D+ W+EGE GR G+FP ++V P +K P +
Sbjct: 204 RGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKLVPRK 250
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 87.0 bits (214), Expect = 5e-17
Identities = 83/290 (28%), Positives = 135/290 (46%), Gaps = 54/290 (18%)
Query: 461 PSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK-EKLPAKAVYDFKAQTSKELSFKKGD 519
PS + R+ +T T S+P G EK E L A+A+Y ++A+ L+F K D
Sbjct: 882 PSAGQLRQRSAFTPATATG---SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKND 938
Query: 520 TVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP----------EKAQPAR----PPPP 565
+ +L + D W+ GE G+ G FP SYV+ ++ P PA P
Sbjct: 939 VITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPA 997
Query: 566 AQPGEIGEA-IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSY 624
A+P GE IA Y + + +L+ ++GD VIL+ + D +W+ G + ++ G+FP +Y
Sbjct: 998 AKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKDGDWWTGTVG--DKAGVFPSNY 1054
Query: 625 VEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYT 684
V + K+++G S ++ + SL KP E Q + +YT
Sbjct: 1055 VRL--KDSEG-----------SGTAGKTGSLGK-KP--------------EIAQVIASYT 1086
Query: 685 PRNEDELELRESDVIDVMEKCDDGWFVGTSR---RTKFFGTFPGNYVKRL 731
++L L +I + +K GW+ G + + + G FP NYVK L
Sbjct: 1087 ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 84.7 bits (208), Expect = 3e-16
Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 33/232 (14%)
Query: 501 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 560
A+Y +++ +L+F++GD + + +K D +W+ G + G+FP +YV
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 561 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP--GTNRQ- 617
+ + EI + IA Y A +L+L G +++ K+ W+EG++ G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYT--ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 618 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF 677
G FP +YV+++ T ++ +P + Q G
Sbjct: 1126 GWFPANYVKLLSPGTS--------------------KITPTEPPKSTALAAVCQVIG--- 1162
Query: 678 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729
+Y+YT +N+DEL + +I+V+ K D W+ G G FP NYVK
Sbjct: 1163 --MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ--VGLFPSNYVK 1210
Score = 75.5 bits (184), Expect = 2e-13
Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 477 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 536
L D S + G+ K+ A+ + + A ++L+ G + I +K W+EGE
Sbjct: 1057 LKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGEL 1116
Query: 537 HGR-----VGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL 590
R +G FP +YV+ L+P K P PP + + I Y++ A + EL+
Sbjct: 1117 QARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF 1176
Query: 591 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 627
KG + +L + D +W++G++ G + G+FP +YV++
Sbjct: 1177 NKGQIINVLNKEDPDWWKGEVNG--QVGLFPSNYVKL 1211
Score = 57.8 bits (138), Expect = 4e-08
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 502 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 558
+YD+ AQ EL+F KG + +L K D +W++GE +G+VG+FP +YV+ T + +Q
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 55.5 bits (132), Expect = 2e-07
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 34/243 (13%)
Query: 500 KAVYDFKAQTSKELSFKKGDTVYILRK-IDQN------WYEGEHHGRVGIFPISYVEKLT 552
+A+Y F++++ E++ + GD V + + +D++ W GE G+ G FP +Y EK+
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 553 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 612
E P +P + + + +T L++ + NW
Sbjct: 806 ENEVPAPVKPVTDSTSAPAPKLALR-----ETPAPLAVTSSEP----STTPNNW------ 850
Query: 613 GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHEN-IQ 671
+ +P S E K T + + P S+ ++ S+ P + + +
Sbjct: 851 -ADFSSTWPTSTNE--KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL 907
Query: 672 GGGEPF-----QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 726
G GE QALY + + ++ L ++DVI V+E+ D WF G + K G FP +
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQK--GWFPKS 964
Query: 727 YVK 729
YVK
Sbjct: 965 YVK 967
Score = 32.0 bits (71), Expect = 2.1
Identities = 16/62 (25%), Positives = 31/62 (50%), Gaps = 9/62 (14%)
Query: 677 FQALYNYTPRNEDELELRESDV-------IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729
++ALY + R+ DE+ ++ D+ +D + + GW G + G FP NY +
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT--GWFPANYAE 802
Query: 730 RL 731
++
Sbjct: 803 KI 804
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 87.0 bits (214), Expect = 5e-17
Identities = 83/290 (28%), Positives = 135/290 (46%), Gaps = 54/290 (18%)
Query: 461 PSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK-EKLPAKAVYDFKAQTSKELSFKKGD 519
PS + R+ +T T S+P G EK E L A+A+Y ++A+ L+F K D
Sbjct: 882 PSAGQLRQRSAFTPATATG---SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKND 938
Query: 520 TVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP----------EKAQPAR----PPPP 565
+ +L + D W+ GE G+ G FP SYV+ ++ P PA P
Sbjct: 939 VITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPA 997
Query: 566 AQPGEIGEA-IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSY 624
A+P GE IA Y + + +L+ ++GD VIL+ + D +W+ G + ++ G+FP +Y
Sbjct: 998 AKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKDGDWWTGTVG--DKAGVFPSNY 1054
Query: 625 VEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYT 684
V + K+++G S ++ + SL KP E Q + +YT
Sbjct: 1055 VRL--KDSEG-----------SGTAGKTGSLGK-KP--------------EIAQVIASYT 1086
Query: 685 PRNEDELELRESDVIDVMEKCDDGWFVGTSR---RTKFFGTFPGNYVKRL 731
++L L +I + +K GW+ G + + + G FP NYVK L
Sbjct: 1087 ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 84.7 bits (208), Expect = 3e-16
Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 33/232 (14%)
Query: 501 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 560
A+Y +++ +L+F++GD + + +K D +W+ G + G+FP +YV
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 561 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP--GTNRQ- 617
+ + EI + IA Y A +L+L G +++ K+ W+EG++ G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYT--ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 618 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF 677
G FP +YV+++ T ++ +P + Q G
Sbjct: 1126 GWFPANYVKLLSPGTS--------------------KITPTEPPKSTALAAVCQVIG--- 1162
Query: 678 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729
+Y+YT +N+DEL + +I+V+ K D W+ G G FP NYVK
Sbjct: 1163 --MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ--VGLFPSNYVK 1210
Score = 75.5 bits (184), Expect = 2e-13
Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 477 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 536
L D S + G+ K+ A+ + + A ++L+ G + I +K W+EGE
Sbjct: 1057 LKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGEL 1116
Query: 537 HGR-----VGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL 590
R +G FP +YV+ L+P K P PP + + I Y++ A + EL+
Sbjct: 1117 QARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF 1176
Query: 591 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 627
KG + +L + D +W++G++ G + G+FP +YV++
Sbjct: 1177 NKGQIINVLNKEDPDWWKGEVNG--QVGLFPSNYVKL 1211
Score = 57.8 bits (138), Expect = 4e-08
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 502 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 558
+YD+ AQ EL+F KG + +L K D +W++GE +G+VG+FP +YV+ T + +Q
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 55.5 bits (132), Expect = 2e-07
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 34/243 (13%)
Query: 500 KAVYDFKAQTSKELSFKKGDTVYILRK-IDQN------WYEGEHHGRVGIFPISYVEKLT 552
+A+Y F++++ E++ + GD V + + +D++ W GE G+ G FP +Y EK+
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 553 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 612
E P +P + + + +T L++ + NW
Sbjct: 806 ENEVPAPVKPVTDSTSAPAPKLALR-----ETPAPLAVTSSEP----STTPNNW------ 850
Query: 613 GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHEN-IQ 671
+ +P S E K T + + P S+ ++ S+ P + + +
Sbjct: 851 -ADFSSTWPTSTNE--KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL 907
Query: 672 GGGEPF-----QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 726
G GE QALY + + ++ L ++DVI V+E+ D WF G + K G FP +
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQK--GWFPKS 964
Query: 727 YVK 729
YVK
Sbjct: 965 YVK 967
Score = 32.0 bits (71), Expect = 2.1
Identities = 16/62 (25%), Positives = 31/62 (50%), Gaps = 9/62 (14%)
Query: 677 FQALYNYTPRNEDELELRESDV-------IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729
++ALY + R+ DE+ ++ D+ +D + + GW G + G FP NY +
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT--GWFPANYAE 802
Query: 730 RL 731
++
Sbjct: 803 KI 804
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 84.0 bits (206), Expect = 5e-16
Identities = 94/372 (25%), Positives = 153/372 (41%), Gaps = 67/372 (18%)
Query: 416 KSEPAVGPPRGL--GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSY 473
++E AV P + L S S TS L + + + S S+ + + ++
Sbjct: 793 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 852
Query: 474 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 533
+ T++ G +P +G E L A+A+ + A+ L+F K D + +L + +NW+
Sbjct: 853 TRTVSP-GSVSPIHGQGQVV-ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWF 909
Query: 534 GEHHGRVGIFPISYVEKLTPPEKAQPARPP---------PPAQPGEIGEA-IAKYNFNAD 583
GE HG G FP SYV K+ P + + P P + +GE IA Y +++
Sbjct: 910 GEVHGGRGWFPKSYV-KIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSV 968
Query: 584 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDY 638
+L+ +G+ +++ ++ D W+ G I +R GIFP +YV E +K
Sbjct: 969 EPGDLTFTEGEEILVTQK-DGEWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASN 1025
Query: 639 PDPPIPH---SYSSDRIHSLSSNKPQRPVFTHEN--------IQGGGEPFQ--------- 678
P I +Y + LS Q + +N +Q G+ Q
Sbjct: 1026 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1085
Query: 679 ---------------------ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRT 717
A+Y+Y NEDEL + +I+VM K D W+ G
Sbjct: 1086 KLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV 1145
Query: 718 KFFGTFPGNYVK 729
G FP NYVK
Sbjct: 1146 T--GLFPSNYVK 1155
Score = 74.3 bits (181), Expect = 4e-13
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 36/220 (16%)
Query: 458 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 517
PS+ + KD+ES S S + G K+ A+ + A S++LS
Sbjct: 1003 PSNYVKPKDQESFGSASKS-------------GASNKKPEIAQVTSAYVASGSEQLSLAP 1049
Query: 518 GDTVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEI 571
G + IL+K W++GE R G FP S+V+ L P E+A PA P +
Sbjct: 1050 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------V 1102
Query: 572 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 631
+ IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1103 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS 1160
Query: 632 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 671
DP + ++ + +R + HE IQ
Sbjct: 1161 --------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1192
Score = 58.2 bits (139), Expect = 3e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 443 PGSSTTLTKSFTSS--SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PA 499
PG + K TS +R K R+ +S + +G P R TP +
Sbjct: 1049 PGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG---PSSERATPAFHPVCQV 1105
Query: 500 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 558
A+YD+ A ELSF KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1106 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1164
Score = 46.6 bits (109), Expect = 8e-05
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 500 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 557
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
Query: 558 QPARPPPPAQP 568
+ P P
Sbjct: 796 KAVSPKKALLP 806
Score = 43.9 bits (102), Expect = 5e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 677 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 731
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 735 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 789
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 84.0 bits (206), Expect = 5e-16
Identities = 94/372 (25%), Positives = 153/372 (41%), Gaps = 67/372 (18%)
Query: 416 KSEPAVGPPRGL--GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSY 473
++E AV P + L S S TS L + + + S S+ + + ++
Sbjct: 820 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 879
Query: 474 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 533
+ T++ G +P +G E L A+A+ + A+ L+F K D + +L + +NW+
Sbjct: 880 TRTVSP-GSVSPIHGQGQVV-ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWF 936
Query: 534 GEHHGRVGIFPISYVEKLTPPEKAQPARPP---------PPAQPGEIGEA-IAKYNFNAD 583
GE HG G FP SYV K+ P + + P P + +GE IA Y +++
Sbjct: 937 GEVHGGRGWFPKSYV-KIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSV 995
Query: 584 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDY 638
+L+ +G+ +++ ++ D W+ G I +R GIFP +YV E +K
Sbjct: 996 EPGDLTFTEGEEILVTQK-DGEWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASN 1052
Query: 639 PDPPIPH---SYSSDRIHSLSSNKPQRPVFTHEN--------IQGGGEPFQ--------- 678
P I +Y + LS Q + +N +Q G+ Q
Sbjct: 1053 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1112
Query: 679 ---------------------ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRT 717
A+Y+Y NEDEL + +I+VM K D W+ G
Sbjct: 1113 KLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV 1172
Query: 718 KFFGTFPGNYVK 729
G FP NYVK
Sbjct: 1173 T--GLFPSNYVK 1182
Score = 74.3 bits (181), Expect = 4e-13
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 36/220 (16%)
Query: 458 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 517
PS+ + KD+ES S S + G K+ A+ + A S++LS
Sbjct: 1030 PSNYVKPKDQESFGSASKS-------------GASNKKPEIAQVTSAYVASGSEQLSLAP 1076
Query: 518 GDTVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEI 571
G + IL+K W++GE R G FP S+V+ L P E+A PA P +
Sbjct: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------V 1129
Query: 572 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 631
+ IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1130 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS 1187
Query: 632 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 671
DP + ++ + +R + HE IQ
Sbjct: 1188 --------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1219
Score = 58.2 bits (139), Expect = 3e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 443 PGSSTTLTKSFTSS--SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PA 499
PG + K TS +R K R+ +S + +G P R TP +
Sbjct: 1076 PGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG---PSSERATPAFHPVCQV 1132
Query: 500 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 558
A+YD+ A ELSF KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Score = 46.6 bits (109), Expect = 8e-05
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 500 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 557
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 558 QPARPPPPAQP 568
+ P P
Sbjct: 823 KAVSPKKALLP 833
Score = 43.9 bits (102), Expect = 5e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 677 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 731
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 816
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 84.0 bits (206), Expect = 5e-16
Identities = 94/372 (25%), Positives = 153/372 (41%), Gaps = 67/372 (18%)
Query: 416 KSEPAVGPPRGL--GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSY 473
++E AV P + L S S TS L + + + S S+ + + ++
Sbjct: 820 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 879
Query: 474 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 533
+ T++ G +P +G E L A+A+ + A+ L+F K D + +L + +NW+
Sbjct: 880 TRTVSP-GSVSPIHGQGQVV-ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWF 936
Query: 534 GEHHGRVGIFPISYVEKLTPPEKAQPARPP---------PPAQPGEIGEA-IAKYNFNAD 583
GE HG G FP SYV K+ P + + P P + +GE IA Y +++
Sbjct: 937 GEVHGGRGWFPKSYV-KIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSV 995
Query: 584 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDY 638
+L+ +G+ +++ ++ D W+ G I +R GIFP +YV E +K
Sbjct: 996 EPGDLTFTEGEEILVTQK-DGEWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASN 1052
Query: 639 PDPPIPH---SYSSDRIHSLSSNKPQRPVFTHEN--------IQGGGEPFQ--------- 678
P I +Y + LS Q + +N +Q G+ Q
Sbjct: 1053 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1112
Query: 679 ---------------------ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRT 717
A+Y+Y NEDEL + +I+VM K D W+ G
Sbjct: 1113 KLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV 1172
Query: 718 KFFGTFPGNYVK 729
G FP NYVK
Sbjct: 1173 T--GLFPSNYVK 1182
Score = 74.3 bits (181), Expect = 4e-13
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 36/220 (16%)
Query: 458 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 517
PS+ + KD+ES S S + G K+ A+ + A S++LS
Sbjct: 1030 PSNYVKPKDQESFGSASKS-------------GASNKKPEIAQVTSAYVASGSEQLSLAP 1076
Query: 518 GDTVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEI 571
G + IL+K W++GE R G FP S+V+ L P E+A PA P +
Sbjct: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------V 1129
Query: 572 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 631
+ IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1130 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS 1187
Query: 632 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 671
DP + ++ + +R + HE IQ
Sbjct: 1188 --------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1219
Score = 58.2 bits (139), Expect = 3e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 443 PGSSTTLTKSFTSS--SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PA 499
PG + K TS +R K R+ +S + +G P R TP +
Sbjct: 1076 PGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG---PSSERATPAFHPVCQV 1132
Query: 500 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 558
A+YD+ A ELSF KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Score = 46.6 bits (109), Expect = 8e-05
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 500 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 557
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 558 QPARPPPPAQP 568
+ P P
Sbjct: 823 KAVSPKKALLP 833
Score = 43.9 bits (102), Expect = 5e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 677 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 731
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 816
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 83.2 bits (204), Expect = 8e-16
Identities = 53/165 (32%), Positives = 96/165 (58%), Gaps = 12/165 (7%)
Query: 575 IAKYNFNADTNVELSLRKGDRVILLKRV-DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 633
I +Y+++A + EL++R G+ + +K++ ++ W EG++ G R+G+FP ++V+ +K+ T+
Sbjct: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRETE 62
Query: 634 GAED-YPDPPIPHSYSSDRIHSLSS-NKPQRPVFTH---ENIQGGGEPFQA--LYNYTPR 686
+D P H + + +S+ P + H +NI+ + Q L+ Y P+
Sbjct: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQ 122
Query: 687 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
NEDELEL+ D+ID+ E+ ++GW+ GT G FP N+VK L
Sbjct: 123 NEDELELKVGDIIDINEEVEEGWWSGTLNNK--LGLFPSNFVKEL 165
Score = 55.8 bits (133), Expect = 1e-07
Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 100/325 (30%)
Query: 503 YDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHHGRVGIFPISYVEKL-TPPEKAQPA 560
YD+ A EL+ + G+ + ++K+ ++ W EGE +GR G+FP ++V+++ E +
Sbjct: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
Query: 561 RPPPPAQPGEIGEAIAK--------------------------------YNFNADTNVEL 588
P + G + + + + + EL
Sbjct: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
Query: 589 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG----AED------- 637
L+ GD + + + V++ W+ G + N+ G+FP ++V+ ++ G A+D
Sbjct: 128 ELKVGDIIDINEEVEEGWWSGTL--NNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLA 185
Query: 638 YPDPPIP---------------------------HSYSSDRIHSLSSN------KPQRPV 664
P PIP S ++ + +S+ KP++P+
Sbjct: 186 GPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPL 245
Query: 665 -------------FTHENIQG---GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CD 706
T + +G E + L+ Y NEDEL +E ++I ++ K +
Sbjct: 246 ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
Query: 707 DGWFVGTSRRTKFFGTFPGNYVKRL 731
GW+ G + G FP N+ ++
Sbjct: 306 AGWWRGELNGKE--GVFPDNFAVQI 328
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 5/88 (5%)
Query: 494 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKL 551
K K + ++ ++ EL+FK+G+ ++++ K + W+ GE +G+ G+FP ++ ++
Sbjct: 269 KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
Query: 552 TPPEK--AQPARPPPPAQ-PGEIGEAIA 576
+K +P +PPPPA+ P E IA
Sbjct: 329 NELDKDFPKPKKPPPPAKAPAPKPELIA 356
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 82.8 bits (203), Expect = 1e-15
Identities = 50/162 (30%), Positives = 90/162 (55%), Gaps = 12/162 (7%)
Query: 573 EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNT 632
EAI ++++ A + EL++ G+ + +++ D W+EG+I G R+G+FP ++V +KK
Sbjct: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
Query: 633 KG---AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 689
K P+ P+ S + + LSS R T++ + Q ++Y P+N+D
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSL--LSSETILR---TNKRGERRRRRCQVAFSYLPQNDD 115
Query: 690 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
ELEL+ D+I+V+ + ++GW+ G G FP N++K L
Sbjct: 116 ELELKVGDIIEVVGEVEEGWWEGVLNGKT--GMFPSNFIKEL 155
Score = 66.2 bits (160), Expect = 1e-10
Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)
Query: 494 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 551
K K K ++ ++AQ EL+ K+GD V ++ K ID W+EGE +GR G+FP ++V KL
Sbjct: 267 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 325
Query: 552 TPP----EKAQPARPPPPAQP 568
PP E +P +PPPP+ P
Sbjct: 326 LPPDFEKEGNRPKKPPPPSAP 346
Score = 63.5 bits (153), Expect = 7e-10
Identities = 37/148 (25%), Positives = 73/148 (49%), Gaps = 26/148 (17%)
Query: 503 YDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARP 562
+D++AQ EL+ G+ + +RK D W+EG+ +GR G+FP ++V ++ K P
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67
Query: 563 PPPAQP-------------------GEIGEAIAK-----YNFNADTNVELSLRKGDRVIL 598
P +P + GE + +++ + EL L+ GD + +
Sbjct: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127
Query: 599 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 626
+ V++ W+EG + G + G+FP ++++
Sbjct: 128 VGEVEEGWWEGVLNG--KTGMFPSNFIK 153
Score = 62.4 bits (150), Expect = 1e-09
Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)
Query: 454 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 513
T+ +P P + S T+ + R RR + + + Q EL
Sbjct: 66 TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 117
Query: 514 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 573
K GD + ++ ++++ W+EG +G+ G+FP +++++L+ + E
Sbjct: 118 ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 177
Query: 574 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 633
+ D++ S +G + Q K+ G IF +++ ++ +
Sbjct: 178 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 232
Query: 634 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 693
D+ +P + + ++ P ++ + + ++ Y +N+DEL +
Sbjct: 233 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 288
Query: 694 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 731
+E D++ ++ K D GW+ G + G FP N+VK L
Sbjct: 289 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
Score = 47.8 bits (112), Expect = 4e-05
Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)
Query: 578 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 635
+ + A + EL++++GD V L+ + +D W+EG++ G R+G+FP ++V+++ + +
Sbjct: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 333
Query: 636 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 687
+ P P P S +++R H + P+RP P + P
Sbjct: 334 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 384
Query: 688 EDELELRESDV 698
E +L+L++ V
Sbjct: 385 EPKLDLQKPSV 395
Score = 40.8 bits (94), Expect = 0.005
Identities = 57/225 (25%), Positives = 80/225 (35%), Gaps = 50/225 (22%)
Query: 244 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEP 303
P+ K+ + P PP PP P+ + +TE RK + +K
Sbjct: 328 PDFEKEGNRPKKPP---PPSAPVIKQGAGTTE--------RKHEIKK------------- 363
Query: 304 GKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPAL 363
+ ERP LP T P R+P + V P PR SR AL
Sbjct: 364 -----IPPERPEMLPNR-TEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGAL 417
Query: 364 SPTRP--PKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFR--------K 413
P RP P PL H+ G + L SS+ L++ +S S D
Sbjct: 418 PPRRPERPVGPL----THTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSST 473
Query: 414 RRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 458
+ S P P+ G + S++ L SS + F S SP
Sbjct: 474 EKLSHPTTSRPKATGRRPPSQS------LTSSSLSSPDIFDSPSP 512
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.129 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,526,756
Number of Sequences: 37866
Number of extensions: 2245338
Number of successful extensions: 26038
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 411
Number of HSP's successfully gapped in prelim test: 1273
Number of HSP's that attempted gapping in prelim test: 14028
Number of HSP's gapped (non-prelim): 9259
length of query: 731
length of database: 18,247,518
effective HSP length: 110
effective length of query: 621
effective length of database: 14,082,258
effective search space: 8745082218
effective search space used: 8745082218
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.