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Search of human proteins with 224586844
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
(644 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 1315 0.0
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 1258 0.0
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 1187 0.0
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 1174 0.0
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 1035 0.0
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 961 0.0
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 590 e-168
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 555 e-158
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 431 e-121
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 408 e-114
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 404 e-112
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 404 e-112
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 357 2e-98
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 281 1e-75
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 238 1e-62
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 228 1e-59
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 214 2e-55
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 108 1e-23
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 101 2e-21
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 101 2e-21
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 96 1e-19
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 91 3e-18
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 88 3e-17
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 87 5e-17
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 87 5e-17
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 84 4e-16
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 84 4e-16
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 84 4e-16
gi|11321634 CD2-associated protein [Homo sapiens] 83 7e-16
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 83 9e-16
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 1315 bits (3403), Expect = 0.0
Identities = 644/644 (100%), Positives = 644/644 (100%)
Query: 1 MSVTLTSVKRVQSSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVR 60
MSVTLTSVKRVQSSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVR
Sbjct: 1 MSVTLTSVKRVQSSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVR 60
Query: 61 PNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDST 120
PNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDST
Sbjct: 61 PNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDST 120
Query: 121 DTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRP 180
DTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRP
Sbjct: 121 DTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRP 180
Query: 181 KDWYKTMFKQIHMVHKPGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVP 240
KDWYKTMFKQIHMVHKPGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVP
Sbjct: 181 KDWYKTMFKQIHMVHKPGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVP 240
Query: 241 PPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPA 300
PPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPA
Sbjct: 241 PPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPA 300
Query: 301 SLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSST 360
SLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSST
Sbjct: 301 SLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSST 360
Query: 361 TLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKA 420
TLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKA
Sbjct: 361 TLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKA 420
Query: 421 QTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQ 480
QTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQ
Sbjct: 421 QTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQ 480
Query: 481 PGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 540
PGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV
Sbjct: 481 PGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 540
Query: 541 VKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 600
VKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN
Sbjct: 541 VKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 600
Query: 601 EDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
EDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 601 EDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 1258 bits (3256), Expect = 0.0
Identities = 624/658 (94%), Positives = 624/658 (94%), Gaps = 34/658 (5%)
Query: 21 GRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNS 80
GRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNS
Sbjct: 4 GRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNS 63
Query: 81 GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL 140
GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL
Sbjct: 64 GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL 123
Query: 141 YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP--- 197
YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP
Sbjct: 124 YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDD 183
Query: 198 ------------GLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP 245
GLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP
Sbjct: 184 TDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP 243
Query: 246 PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP------ 299
PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP
Sbjct: 244 PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPKKPL 303
Query: 300 -------------ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS 346
ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS
Sbjct: 304 DYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS 363
Query: 347 RTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPE 406
RTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPE
Sbjct: 364 RTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPE 423
Query: 407 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 466
KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP
Sbjct: 424 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 483
Query: 467 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 526
PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG
Sbjct: 484 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 543
Query: 527 TNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 586
TNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG
Sbjct: 544 TNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 603
Query: 587 GEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
GEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 604 GEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 1187 bits (3070), Expect = 0.0
Identities = 601/686 (87%), Positives = 601/686 (87%), Gaps = 85/686 (12%)
Query: 21 GRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNS 80
GRDSQSPDSA KGFRSVRPNLQDKRSPTQSQITVNGNS
Sbjct: 4 GRDSQSPDSA-----------------------KGFRSVRPNLQDKRSPTQSQITVNGNS 40
Query: 81 GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL 140
GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL
Sbjct: 41 GGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPL 100
Query: 141 YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP--- 197
YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP
Sbjct: 101 YRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDD 160
Query: 198 ------------GLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP 245
GLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP
Sbjct: 161 TDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVP 220
Query: 246 PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP------ 299
PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP
Sbjct: 221 PPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPTDRINP 280
Query: 300 -----------------------------------------ASLYQSSIDRSLERPMSSA 318
ASLYQSSIDRSLERPMSSA
Sbjct: 281 DDIDLENEPWYKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSA 340
Query: 319 SMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK 378
SMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK
Sbjct: 341 SMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK 400
Query: 379 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 438
DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR
Sbjct: 401 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 460
Query: 439 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 498
KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN
Sbjct: 461 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 520
Query: 499 VELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPH 558
VELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPH
Sbjct: 521 VELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPH 580
Query: 559 SYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC 618
SYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC
Sbjct: 581 SYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC 640
Query: 619 DDGWFVGTSRRTKFFGTFPGNYVKRL 644
DDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 641 DDGWFVGTSRRTKFFGTFPGNYVKRL 666
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 1174 bits (3036), Expect = 0.0
Identities = 612/731 (83%), Positives = 617/731 (84%), Gaps = 87/731 (11%)
Query: 1 MSVTLTSVKRVQSSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVR 60
MSVTLTSVKRVQSSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVR
Sbjct: 1 MSVTLTSVKRVQSSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVR 60
Query: 61 PNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDST 120
PNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDST
Sbjct: 61 PNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDST 120
Query: 121 DTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRP 180
DTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRP
Sbjct: 121 DTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRP 180
Query: 181 KDWYKTMFKQIHMVHKP---------------GLYNPPYSAQSHPAAKTQTYRPLSKSHS 225
KDWYKTMFKQIHMVHKP GLYNPPYSAQSHPAAKTQTYRPLSKSHS
Sbjct: 181 KDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHS 240
Query: 226 DNSPNAFKDASSPVPPPHVPPPV-----------------PPLRPRD------------- 255
DNSPNAFKDASSPVPPPHVPPPV PP R D
Sbjct: 241 DNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFE 300
Query: 256 ----RSSTEKHDWDPPDRKVDT-------RKFRSE-------------PRSIFEYEPGKS 291
+SS +H+ PP T RK S PRS ++
Sbjct: 301 YEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRA 360
Query: 292 SILQHERP------------------ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPA 333
L RP ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPA
Sbjct: 361 PALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPA 420
Query: 334 VGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM 393
VGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM
Sbjct: 421 VGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM 480
Query: 394 GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRV 453
GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRV
Sbjct: 481 GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRV 540
Query: 454 GIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLK 513
GIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLK
Sbjct: 541 GIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLK 600
Query: 514 RVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKP 573
RVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKP
Sbjct: 601 RVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKP 660
Query: 574 QRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFF 633
QRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFF
Sbjct: 661 QRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFF 720
Query: 634 GTFPGNYVKRL 644
GTFPGNYVKRL
Sbjct: 721 GTFPGNYVKRL 731
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 1035 bits (2676), Expect = 0.0
Identities = 541/660 (81%), Positives = 546/660 (82%), Gaps = 87/660 (13%)
Query: 72 SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD 131
SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD
Sbjct: 165 SQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLD 224
Query: 132 GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 191
GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI
Sbjct: 225 GTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 284
Query: 192 HMVHKP---------------GLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 236
HMVHKP GLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS
Sbjct: 285 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 344
Query: 237 SPVPPPHVPPPV-----------------PPLRPRD-----------------RSSTEKH 262
SPVPPPHVPPPV PP R D +SS +H
Sbjct: 345 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 404
Query: 263 DWDPPDRKVDT-------RKFRSE-------------PRSIFEYEPGKSSILQHERP--- 299
+ PP T RK S PRS ++ L RP
Sbjct: 405 ERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKK 464
Query: 300 ---------------ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS 344
ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS
Sbjct: 465 PLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS 524
Query: 345 ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT 404
ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT
Sbjct: 525 ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT 584
Query: 405 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 464
PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL
Sbjct: 585 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 644
Query: 465 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 524
TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI
Sbjct: 645 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 704
Query: 525 PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 584
PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ
Sbjct: 705 PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 764
Query: 585 GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 765 GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 961 bits (2483), Expect = 0.0
Identities = 469/484 (96%), Positives = 469/484 (96%), Gaps = 15/484 (3%)
Query: 176 TVDRPKDWYKTMFKQIHMVHKP---------------GLYNPPYSAQSHPAAKTQTYRPL 220
TVDRPKDWYKTMFKQIHMVHKP GLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 9 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 68
Query: 221 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 280
SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 69 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 128
Query: 281 RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL 340
RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL
Sbjct: 129 RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL 188
Query: 341 GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE 400
GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE
Sbjct: 189 GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE 248
Query: 401 RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISY 460
RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISY
Sbjct: 249 RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISY 308
Query: 461 VEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWY 520
VEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWY
Sbjct: 309 VEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWY 368
Query: 521 EGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTH 580
EGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTH
Sbjct: 369 EGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTH 428
Query: 581 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNY 640
ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNY
Sbjct: 429 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNY 488
Query: 641 VKRL 644
VKRL
Sbjct: 489 VKRL 492
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 590 bits (1521), Expect = e-168
Identities = 304/364 (83%), Positives = 312/364 (85%), Gaps = 26/364 (7%)
Query: 87 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 146
MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE
Sbjct: 1 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE 60
Query: 147 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP--------- 197
EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP
Sbjct: 61 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT 120
Query: 198 ------GLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 251
GLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL
Sbjct: 121 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL 180
Query: 252 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSL 311
RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSL
Sbjct: 181 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSL 240
Query: 312 ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 371
ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP
Sbjct: 241 ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 300
Query: 372 SSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVY----DFKAQTSKELS 427
SSPSRAK + + S + G + G P E L + Y D + + +S
Sbjct: 301 SSPSRAKGGDDSKICPSLCSYSGLN------GNPSSE-LDYCSTYRQHLDVPRDSPRAIS 353
Query: 428 FKKG 431
FK G
Sbjct: 354 FKNG 357
Score = 555 bits (1429), Expect = e-158
Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)
Query: 322 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 377
S R R+S P P L A P + D +P S++ +SS R
Sbjct: 773 SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 831
Query: 378 --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 435
+DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 832 ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 891
Query: 436 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 495
ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 892 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 951
Query: 496 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 555
DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 952 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 1011
Query: 556 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 615
IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 1012 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 1071
Query: 616 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 1072 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 555 bits (1429), Expect = e-158
Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)
Query: 322 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 377
S R R+S P P L A P + D +P S++ +SS R
Sbjct: 677 SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 735
Query: 378 --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 435
+DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 736 ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 795
Query: 436 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 495
ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 796 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 855
Query: 496 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 555
DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 856 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 915
Query: 556 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 615
IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 916 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 975
Query: 616 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 976 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 423 bits (1088), Expect = e-118
Identities = 215/260 (82%), Positives = 223/260 (85%), Gaps = 11/260 (4%)
Query: 176 TVDRPKDWYKTMFKQIHMVHKPGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDA 235
TVDRPKDWYKTMFKQIHMVHKPGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDA
Sbjct: 9 TVDRPKDWYKTMFKQIHMVHKPGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDA 68
Query: 236 SSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQ 295
SSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQ
Sbjct: 69 SSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQ 128
Query: 296 HERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDL 355
HERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDL
Sbjct: 129 HERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDL 188
Query: 356 PGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAV 415
PGSSTTLTKSFTSSSPSSPSRAK + + S + G + G P E L +
Sbjct: 189 PGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLN------GNPSSE-LDYCST 241
Query: 416 Y----DFKAQTSKELSFKKG 431
Y D + + +SFK G
Sbjct: 242 YRQHLDVPRDSPRAISFKNG 261
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 431 bits (1109), Expect = e-121
Identities = 281/653 (43%), Positives = 367/653 (56%), Gaps = 44/653 (6%)
Query: 13 SSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQS 72
SSP R +S WR + + NG+A SSLAAKG+RSV PNL +S S
Sbjct: 53 SSPASPQETRQHESKPDEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS 109
Query: 73 QITVNGNSGGAVSPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYP 124
+ +S + + PS AY +N +IV+ Q S S
Sbjct: 110 PLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSE 169
Query: 125 QHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDR 179
+ D + P EKR V+K+ +DE GIP +R T +R
Sbjct: 170 RRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ER 226
Query: 180 PKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 236
KDWYKTMFKQIH +++ LY+P YS T PLS S S ++ D
Sbjct: 227 SKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSEMSYIDGE 279
Query: 237 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 296
V P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +
Sbjct: 280 KVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTN 338
Query: 297 ERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQSASRTSPGRVDL 355
E+ +S + + S E P +S+F +R+S+ A G L ++ S L
Sbjct: 339 EKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSV----L 392
Query: 356 PGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAKA 414
G L PSS + KD ESPR + D S RR +KE PA+A
Sbjct: 393 EGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA--DYLESTEEFIRRRHDDKEMRPARA 450
Query: 415 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR 474
+DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP +
Sbjct: 451 KFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKK 510
Query: 475 PPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFP 534
P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP
Sbjct: 511 LTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFP 569
Query: 535 VSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--Q 591
++YV+V+K+ K DY D P S S S + Q+ T + Q + F Q
Sbjct: 570 ITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQ 629
Query: 592 ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
ALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 630 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 408 bits (1048), Expect = e-114
Identities = 279/703 (39%), Positives = 372/703 (52%), Gaps = 88/703 (12%)
Query: 13 SSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQS 72
SSP R +S WR + + NG+A SSLAAKG+RSV PNL +S S
Sbjct: 53 SSPASPQETRQHESKPDEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS 109
Query: 73 QITVNGNSGGAVSPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYP 124
+ +S + + PS AY +N +IV+ Q S S
Sbjct: 110 PLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSE 169
Query: 125 QHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDR 179
+ D + P EKR V+K+ +DE GIP +R T +R
Sbjct: 170 RRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ER 226
Query: 180 PKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 236
KDWYKTMFKQIH +++ LY+P YS T PLS S S ++ D
Sbjct: 227 SKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSEMSYIDGE 279
Query: 237 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 296
V P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +
Sbjct: 280 KVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTN 338
Query: 297 ERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQSA---SRTSPGR 352
E+ +S + + S E P +S+F +R+S+ A G L ++ S G
Sbjct: 339 EKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGD 396
Query: 353 VDLPGSSTTLTKSFTSSSPSSPS-------------------RAKDRE------------ 381
+ L G S S ++S+ S S R D+E
Sbjct: 397 IPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKRE 456
Query: 382 ------SPRSYSSTLTDMGRSAPRERRGT-----------PEKEKLPAKAVYDFKAQTSK 424
+ R ++ + + ER G E PA+A +DFKAQT K
Sbjct: 457 QEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLK 516
Query: 425 ELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEI 484
EL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E
Sbjct: 517 ELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEY 575
Query: 485 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 544
GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+
Sbjct: 576 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 635
Query: 545 -TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNE 601
K DY D P S S S + Q+ T + Q + F QALY+Y P+N+
Sbjct: 636 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 695
Query: 602 DELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 696 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 404 bits (1039), Expect = e-112
Identities = 277/691 (40%), Positives = 369/691 (53%), Gaps = 90/691 (13%)
Query: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 84
P SA WR + + NG+A SSLAAKG+RSV PNL +S S + +S
Sbjct: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIG 162
Query: 85 SPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYPQHAQSLDGTTSS 136
+ + PS AY +N +IV+ Q S S + D +
Sbjct: 163 TDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ 222
Query: 137 SIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 191
P EKR V+K+ +DE GIP +R T +R KDWYKTMFKQI
Sbjct: 223 EKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQI 279
Query: 192 HMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPV 248
H +++ LY+P YS T PLS S S ++ D V P+
Sbjct: 280 HKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSEMSYIDGEKVVKRS-ATLPL 331
Query: 249 PPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSID 308
P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ +S + +
Sbjct: 332 PARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPE 391
Query: 309 RSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQSA---SRTSPGRVDLPGSSTTLTK 364
S E P +S+F +R+S+ A G L ++ S G + L G S
Sbjct: 392 ISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRP 449
Query: 365 SFTSSSPSSPS-------------------RAKDRE------------------SPRSYS 387
S ++S+ S S R D+E + R ++
Sbjct: 450 SSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHT 509
Query: 388 STLTDMGRSAPRERRGT-----------PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYI 436
+ + ER G E PA+A +DFKAQT KEL +KGD VYI
Sbjct: 510 GVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYI 569
Query: 437 LRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNAD 496
++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN D
Sbjct: 570 YKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGD 628
Query: 497 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPP 555
T VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P
Sbjct: 629 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLP 688
Query: 556 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVID 613
S S S + Q+ T + Q + F QALY+Y P+N+DELELR+ D++D
Sbjct: 689 FSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVD 748
Query: 614 VMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
VMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 749 VMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 404 bits (1039), Expect = e-112
Identities = 264/610 (43%), Positives = 343/610 (56%), Gaps = 42/610 (6%)
Query: 57 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 111
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 225 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 284
Query: 112 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 162
Q S S + D + P EKR V+K+
Sbjct: 285 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 344
Query: 163 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRP 219
+DE GIP +R T +R KDWYKTMFKQIH +++ LY+P YS T P
Sbjct: 345 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSP 395
Query: 220 LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSE 279
LS S S ++ D V P+P +SS+E++DW+PPD+KVDTRK+R+E
Sbjct: 396 LSVPRS-KSEMSYIDGEKVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE 453
Query: 280 PRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPR 338
P+SI+EY+PGKSS+L +E+ +S + + S E P +S+F +R+S+ A G
Sbjct: 454 PKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLT 511
Query: 339 GLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAP 398
L ++ S L G L PSS + KD ESPR + D S
Sbjct: 512 SLENERQIYKSV----LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA--DYLESTE 565
Query: 399 RE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 457
RR +KE PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP
Sbjct: 566 EFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFP 625
Query: 458 ISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 517
+Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+
Sbjct: 626 RTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 684
Query: 518 NWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRP 576
NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S S + Q+
Sbjct: 685 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQR 744
Query: 577 VFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFG 634
T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FG
Sbjct: 745 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG 804
Query: 635 TFPGNYVKRL 644
TFPGNYVK L
Sbjct: 805 TFPGNYVKPL 814
Score = 46.2 bits (108), Expect = 9e-05
Identities = 138/660 (20%), Positives = 225/660 (34%), Gaps = 143/660 (21%)
Query: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 84
P SA WR + + NG+A SSLAAKG+RSV PNL + SQ + ++
Sbjct: 74 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDK----SQDATSSSAA--- 123
Query: 85 SPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHA-QSLDGTTSSSIPLYRS 143
P +P L ++ Q GT+ T P ++ T S++ PL
Sbjct: 124 ----------QPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPL--- 170
Query: 144 SEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPGLYNPP 203
P + IP P L P
Sbjct: 171 -----------------TFPTLDDFIP--------------------------PHLQRWP 187
Query: 204 YSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHD 263
+ +Q PA + ++ P+S++ SP PPP+ P P D + D
Sbjct: 188 HHSQ--PARASGSFAPISQTPPSFSP---------------PPPLVPPAPEDLRRVSEPD 230
Query: 264 WDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSS---------IDRSLERP 314
D+ +E S + +P+S Y S+ + + E+
Sbjct: 231 LTGAVSSTDSSPLLNEVSSSL-IGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQ 289
Query: 315 MSSASMASDFRKRRKSE----PAVGPPRGLG-----------------DQSASRTSPGRV 353
+S++ +RR E P P G Q S S V
Sbjct: 290 KRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEV 349
Query: 354 DLPGSSTTLTKS-----FTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTP--E 406
+P +T +K F + D SPR S T S PR + +
Sbjct: 350 GIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYID 409
Query: 407 KEKLPAK-AVYDFKAQTSK-ELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 464
EK+ + A A++S + S ++ D +K+D Y E P +
Sbjct: 410 GEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGK--SSV 467
Query: 465 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 524
EK A P P E I NF+A E GD L ++ Y+ +
Sbjct: 468 LTNEKMSSAISPTPEISSETPGYIYSSNFHA-VKRESDGAPGDLTSL--ENERQIYKSVL 524
Query: 525 PGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 584
G G P+ + +K+ + A H +D + S +R H++ +
Sbjct: 525 EG----GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR----HDDKE 576
Query: 585 GGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
P +A +++ + EL L++ D++ + ++ D W+ G G FP Y++ L
Sbjct: 577 --MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR--VGIFPRTYIELL 632
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 357 bits (915), Expect = 2e-98
Identities = 281/815 (34%), Positives = 382/815 (46%), Gaps = 214/815 (26%)
Query: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 84
P SA WR + + NG+A SSLAAKG+RSV PNL +S + + G+
Sbjct: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSF 162
Query: 85 SPMSYYQRPFSPSAYSLPAS------LNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSI 138
+P+S FSP +P + ++ + +S DS+ + + SL GT S +
Sbjct: 163 APISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAF 222
Query: 139 P---------------------LYRSSEEEKRVTVI------------------KAPHYP 159
P L + E++KR++ + + P P
Sbjct: 223 PSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSP 282
Query: 160 GIG----------------------PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP 197
G +DE GIP +R T +R KDWYKTMFKQIH +++
Sbjct: 283 GKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRD 339
Query: 198 G---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPR 254
LY+P YS T PLS S S ++ D V P+P
Sbjct: 340 DDSDLYSPRYSFSE------DTKSPLSVPRS-KSEMSYIDGEKVVKRS-ATLPLPARSSS 391
Query: 255 DRSSTEKHDWDPPDRKVDTRKFRSEP---------------------------------- 280
+SS+E++DW+PPD+KVDTRK+R+EP
Sbjct: 392 LKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEP 451
Query: 281 ---------------RSIFEYEPGKSSILQHE-RPASLYQSSIDRSLERPMSSASMASDF 324
+ I++Y PG SIL E R +S + + S E P +S+F
Sbjct: 452 WYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKSSAISPTPEISSETP--GYIYSSNF 509
Query: 325 RK-RRKSEPAVGPPRGLGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS----- 375
+R+S+ A G L ++ S G + L G S S ++S+ S S
Sbjct: 510 HAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFI 569
Query: 376 --------------RAKDRE------------------SPRSYSSTLTDMGRSAPRERRG 403
R D+E + R ++ + + ER G
Sbjct: 570 PADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFG 629
Query: 404 T-----------PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGR 452
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGR
Sbjct: 630 DLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 689
Query: 453 VGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILL 512
VGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL
Sbjct: 690 VGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLL 748
Query: 513 KRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRI------ 565
++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 749 RQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLS 808
Query: 566 -HSLSSN-------------KPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRES 609
HSL + + Q+ T + Q + F QALY+Y P+N+DELELR+
Sbjct: 809 HHSLRAGPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 868
Query: 610 DVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 869 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 903
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 281 bits (719), Expect = 1e-75
Identities = 200/595 (33%), Positives = 287/595 (48%), Gaps = 102/595 (17%)
Query: 125 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY 184
QH Q+ T + S +KR Y GIGPVDESG+P A R++VDRP+DWY
Sbjct: 98 QHTQNWSATWTKD-----SKRRDKRWV-----KYEGIGPVDESGMPIAPRSSVDRPRDWY 147
Query: 185 KTMFKQIHMVHKPGLY------NPPYSAQSHPAAKTQTYRP--------LSKSHSDNSPN 230
+ MF+QIH P L PP + A + +RP S HS+ P
Sbjct: 148 RRMFQQIHR-KMPDLQLDWTFEEPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPR 206
Query: 231 AFKDASSPVPPPHVPPPVPPLRPRDRSST--EKHDWDPPDRKVDTRKFRSEPRSIFEYEP 288
+ + + P LR R++ + W+ ++++T + P+ +P
Sbjct: 207 STFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQ---RPKKPLVDDP 263
Query: 289 GKSSI----LQHERPASLYQSSID---RSLERPMSSASMASDFRKRRKSEPAVGPPRGLG 341
G+ + ER + + +D R++E + S + R+ + P GP
Sbjct: 264 GEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPA---- 319
Query: 342 DQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRER 401
SA +S GS+ +L+ + S +D P S G +P R
Sbjct: 320 --SAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARR 377
Query: 402 RGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYV 461
EK++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+NW EGEHHGR+GIFP +YV
Sbjct: 378 E---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYV 434
Query: 462 EKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYE 521
E L E +P + PP Q E GEA+A+Y F D VELS RKG+ + L+++V++NWYE
Sbjct: 435 EVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYE 493
Query: 522 GKIPGTNRQGIFPVSYVEVVK-----------------KNTKGAEDYPDPPIPHSYSS-- 562
G+I GT RQGIFP SYV+V + + T A P P + S
Sbjct: 494 GRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPA 553
Query: 563 DRIHSLSSNKPQRPVFTH---------ENIQGGG-------------------------- 587
D I P+R F+ +N+ G
Sbjct: 554 DPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIH 613
Query: 588 -EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 641
P++A+Y Y P+NEDELELRE D +DVM++CDDGWFVG SRRT+ FGTFPGNYV
Sbjct: 614 WTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 489 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 541
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 238 bits (607), Expect = 1e-62
Identities = 217/695 (31%), Positives = 294/695 (42%), Gaps = 194/695 (27%)
Query: 57 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 111
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 257 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 316
Query: 112 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 162
Q S S + D + P EKR V+K+
Sbjct: 317 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 376
Query: 163 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPGLYNPPY---------------SAQ 207
+DE GIP +R T +R KDWYKTMFKQIH +++ PY S +
Sbjct: 377 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEE 433
Query: 208 SHPAAKTQTY---RPLSKSHSDNSP------NAFKDASSPVPPPHVPP------------ 246
+P T + P KS D+S + +D SP+ P
Sbjct: 434 DNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVK 493
Query: 247 -----PVPPLRPRDRSSTEKHDWDPPDRKVDTR--------------------------- 274
P+P +SS+E++DW+PPD+KVDTR
Sbjct: 494 RSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSR 553
Query: 275 ---------------KFRSE-------PRSIFEYEPGKSSILQHE-------RPASLYQS 305
KF SE P+ I++Y PG SIL E + SL Q+
Sbjct: 554 DISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQT 613
Query: 306 SIDRSLER------------PMSSASM--------------ASDFRK-RRKSEPAVGPPR 338
++ LE+ P SSA +S+F +R+S+ A G
Sbjct: 614 ELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 673
Query: 339 GLGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS-------------------R 376
L ++ S G + L G S S ++S+ S S R
Sbjct: 674 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR 733
Query: 377 AKDRE------------------SPRSYSSTLTDMGRSAPRERRGT-----------PEK 407
D+E + R ++ + + ER G
Sbjct: 734 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS 793
Query: 408 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 467
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 794 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 853
Query: 468 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 527
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 854 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 912
Query: 528 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYS 561
+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 913 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPS 947
Score = 102 bits (254), Expect = 1e-21
Identities = 44/55 (80%), Positives = 51/55 (92%)
Query: 590 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
+QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 40.8 bits (94), Expect = 0.004
Identities = 27/110 (24%), Positives = 47/110 (42%), Gaps = 7/110 (6%)
Query: 362 LTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA-----KAVY 416
L +F S R + E ++ + ++RR TP++ + +A+Y
Sbjct: 1181 LGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALY 1240
Query: 417 DFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 464
+ Q EL + GD V ++ K D W+ G + G FP +YV+ L
Sbjct: 1241 SYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 38.1 bits (87), Expect = 0.025
Identities = 18/51 (35%), Positives = 29/51 (56%)
Query: 489 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 539
A Y++ + EL LR GD V ++++ D W+ G T + G FP +YV+
Sbjct: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
Score = 36.2 bits (82), Expect = 0.096
Identities = 22/44 (50%), Positives = 27/44 (61%), Gaps = 5/44 (11%)
Query: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRS 68
P SA WR + + NG+A SSLAAKG+RSV PNL +S
Sbjct: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKS 146
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 228 bits (582), Expect = 1e-59
Identities = 131/319 (41%), Positives = 175/319 (54%), Gaps = 59/319 (18%)
Query: 378 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 437
+D P S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI
Sbjct: 12 RDFVYPSSTRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIH 68
Query: 438 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADT 497
+++D+NW EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D
Sbjct: 69 KEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDL 127
Query: 498 NVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK--------------- 542
VELS RKG+ + L+++V++NWYEG+I GT RQGIFP SYV+V +
Sbjct: 128 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPT 187
Query: 543 --KNTKGAEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG-- 587
+ T A P P + S D I P+R F+ +N+ G
Sbjct: 188 SPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPA 247
Query: 588 -------------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGW 622
P++A+Y Y P+NEDELELRE D +DVM++CDDGW
Sbjct: 248 LSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGW 307
Query: 623 FVGTSRRTKFFGTFPGNYV 641
FVG SRRT+ FGTFPGNYV
Sbjct: 308 FVGVSRRTQKFGTFPGNYV 326
Score = 69.7 bits (169), Expect = 8e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 460 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 519
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 16 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 75
Query: 520 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 579
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 76 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 110
Query: 580 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 639
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 111 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 166
Query: 640 YVK 642
YV+
Sbjct: 167 YVQ 169
Score = 45.4 bits (106), Expect = 2e-04
Identities = 33/126 (26%), Positives = 60/126 (47%), Gaps = 12/126 (9%)
Query: 344 SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR---SYS---STLTDMGRSA 397
SA R+ +DL G ++ F+ + + ++ +P S+S S D+G S+
Sbjct: 205 SALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSS 264
Query: 398 PRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGI 455
P T + P +A+Y ++ Q EL ++GD V ++++ D W+ G + G
Sbjct: 265 PN----TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGT 320
Query: 456 FPISYV 461
FP +YV
Sbjct: 321 FPGNYV 326
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 489 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 541
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 214 bits (545), Expect = 2e-55
Identities = 174/525 (33%), Positives = 236/525 (44%), Gaps = 144/525 (27%)
Query: 199 LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSS 258
LY+P YS T PLS S S ++ D V P+P +SS
Sbjct: 481 LYSPRYSFSE------DTKSPLSVPRS-KSEMSYIDGEKVVKRS-ATLPLPARSSSLKSS 532
Query: 259 TEKHDWDPPDRKVDTR------------------------------------------KF 276
+E++DW+PPD+KVDTR KF
Sbjct: 533 SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKF 592
Query: 277 RSE-------PRSIFEYEPGKSSILQHE-------RPASLYQSSIDRSLER--------- 313
SE P+ I++Y PG SIL E + SL Q+ ++ LE+
Sbjct: 593 FSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPS 652
Query: 314 ---PMSSASM--------------ASDFRK-RRKSEPAVGPPRGLGDQSA---SRTSPGR 352
P SSA +S+F +R+S+ A G L ++ S G
Sbjct: 653 ANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGD 712
Query: 353 VDLPGSSTTLTKSFTSSSPSSPS-------------------RAKDRE------------ 381
+ L G S S ++S+ S S R D+E
Sbjct: 713 IPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKRE 772
Query: 382 ------SPRSYSSTLTDMGRSAPRERRGT-----------PEKEKLPAKAVYDFKAQTSK 424
+ R ++ + + ER G E PA+A +DFKAQT K
Sbjct: 773 QEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLK 832
Query: 425 ELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEI 484
EL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E
Sbjct: 833 ELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEY 891
Query: 485 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 544
GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+
Sbjct: 892 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 951
Query: 545 -TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 588
K DY D P S S S + + + + +G GE
Sbjct: 952 LVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGE 996
Score = 148 bits (373), Expect = 2e-35
Identities = 105/298 (35%), Positives = 146/298 (48%), Gaps = 49/298 (16%)
Query: 383 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 442
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 865 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 924
Query: 443 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPP------ 477
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 925 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
Query: 478 ---------PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 528
+ G G I+K + ++V L R+ D N E PG
Sbjct: 985 QYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLS-----DLNTPEESRPGKP 1039
Query: 529 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 588
FP S E +++ G + ++ R S QR V T + Q +
Sbjct: 1040 LGSAFPGSEAEQTERHRGGEQ-------AGRKAARRGGSQQPQAQQRRV-TPDRSQTSQD 1091
Query: 589 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1092 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
Score = 86.7 bits (213), Expect = 6e-17
Identities = 90/319 (28%), Positives = 125/319 (39%), Gaps = 80/319 (25%)
Query: 57 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 111
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 257 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 316
Query: 112 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 162
Q S S + D + P EKR V+K+
Sbjct: 317 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 376
Query: 163 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHK----PGLYNPPYSAQSHPAAKTQTYR 218
+DE GIP +R T +R KDWYKTMFKQIH +++ Y P Y P + +
Sbjct: 377 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEE 433
Query: 219 PLSKS---------------------HSDNSPNA---------------------FKDAS 236
S S S N P + +D
Sbjct: 434 TKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSDLYSPRYSFSEDTK 493
Query: 237 SPVPPPHVPPPVP--------------PLRPRDRS---STEKHDWDPPDRKVDTRKFRSE 279
SP+ P + PL R S S+E++DW+PPD+KVDTRK+R+E
Sbjct: 494 SPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE 553
Query: 280 PRSIFEYEPGKSSILQHER 298
P+SI+EY+PGKSS+L +E+
Sbjct: 554 PKSIYEYQPGKSSVLTNEK 572
Score = 36.2 bits (82), Expect = 0.096
Identities = 22/44 (50%), Positives = 27/44 (61%), Gaps = 5/44 (11%)
Query: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRS 68
P SA WR + + NG+A SSLAAKG+RSV PNL +S
Sbjct: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKS 146
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 108 bits (271), Expect = 1e-23
Identities = 99/417 (23%), Positives = 173/417 (41%), Gaps = 52/417 (12%)
Query: 240 PPPHVPP--PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHE 297
PP VPP P PP R S +K ++ +D +K +S + KS + +++
Sbjct: 338 PPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLAT--GLSKAKSQVFKNQ 395
Query: 298 RPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPG 357
P RP + S + + P G+ ++ +PG +
Sbjct: 396 DPVLP---------PRPKPGHPLYSKYM--------LSVPHGIANEDIVSQNPGELSCKR 438
Query: 358 SSTTLTKSFTSSSPSSPSRAKDRESPR-SYSSTLTDMGRSAPRERRGTPEKEKLP----- 411
+ T ++ + +D S +T + R R P + P
Sbjct: 439 GDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL-RSRPNDPSHAQKPVDSGA 497
Query: 412 --AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PE 468
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 498 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 557
Query: 469 KAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 528
R + + +A++ + + ELS +G+ +IL + V++ W G++ G
Sbjct: 558 GGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG-- 615
Query: 529 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 588
R GIFP+++VE V EDYP S + S + + N Q
Sbjct: 616 RTGIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSL 661
Query: 589 P---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
P +AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 662 PAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 716
Score = 84.3 bits (207), Expect = 3e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 410 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 466
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
Query: 467 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 526
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 721 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 774
Query: 527 TNRQGIFPVSYVEVVK 542
+ GIFP +Y++ ++
Sbjct: 775 --KSGIFPKNYIQFLQ 788
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 101 bits (252), Expect = 2e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 412 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 470
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 500
Query: 471 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 530
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 501 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 558
Query: 531 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 589
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 559 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 604
Query: 590 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 605 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 657
Score = 84.3 bits (207), Expect = 3e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 410 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 466
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
Query: 467 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 526
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 662 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 715
Query: 527 TNRQGIFPVSYVEVVK 542
+ GIFP +Y++ ++
Sbjct: 716 --KSGIFPKNYIQFLQ 729
Score = 75.9 bits (185), Expect = 1e-13
Identities = 113/510 (22%), Positives = 193/510 (37%), Gaps = 82/510 (16%)
Query: 156 PHYPGIGPVDESGIP-TAIRTTVDRPKDWYKTMFKQIHMVHKPGLYNPPYSAQSHPAAKT 214
P PG GP+ ES + T RP K++ + NP Y P+A
Sbjct: 117 PEIPGRGPLAESSDSGKKVPTPAPRPLLLKKSVSSE----------NPTY-----PSAPL 161
Query: 215 QTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPV---PPLRPRDRSSTEKHDWDPPDRKV 271
+ + + A+K PP + P PV PL D S + P +
Sbjct: 162 KPVTVPPRLAGASQAKAYKSLGEG-PPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNL 220
Query: 272 DTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKS- 330
SE +P L E+P S++ L + ++ S+ +
Sbjct: 221 AEESVGSEMVLGLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGF 280
Query: 331 --EPAVGPPRGLG------DQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRES 382
P PPR + Q ++ P R P S T + P + S + D +
Sbjct: 281 VRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSAT--RRSNKKLPFNRS-SSDMDL 337
Query: 383 PRSYSSTLTDMGRSAPRERRGT----PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 438
+ S+ T + ++ + + P + K P +Y + +GD + +L+
Sbjct: 338 QKKQSNLATGLSKAKSQVFKNQDPVLPPRPK-PGHPLYS---------KYMRGDVLVMLK 387
Query: 439 KIDQNWYE---GEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIG--EAIAKYNF 493
+ + N+ E GE GRV + + + L +++P P +P + G A+ ++F
Sbjct: 388 QTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDF 447
Query: 494 NADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPD 553
A+ +L+L G+ V LL+++D +WY G N+ GIFP +YV+V+ +G +
Sbjct: 448 PAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVIIDIPEGGNGKRE 505
Query: 554 PPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVID 613
H R A + Y +DEL E ++I
Sbjct: 506 CVSSHCVKGSRC-------------------------VARFEYIGEQKDELSFSEGEIII 540
Query: 614 VMEKCDDGWFVGTSR-RTKFFGTFPGNYVK 642
+ E ++ W G R RT G FP N+V+
Sbjct: 541 LKEYVNEEWARGEVRGRT---GIFPLNFVE 567
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 101 bits (252), Expect = 2e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 412 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 470
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 536
Query: 471 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 530
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 537 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 594
Query: 531 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 589
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 595 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 640
Query: 590 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 641 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 693
Score = 84.3 bits (207), Expect = 3e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 410 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 466
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
Query: 467 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 526
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 698 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 751
Query: 527 TNRQGIFPVSYVEVVK 542
+ GIFP +Y++ ++
Sbjct: 752 --KSGIFPKNYIQFLQ 765
Score = 74.7 bits (182), Expect = 2e-13
Identities = 114/542 (21%), Positives = 199/542 (36%), Gaps = 110/542 (20%)
Query: 156 PHYPGIGPVDESGIP-TAIRTTVDRPKDWYKTMFKQIHMVHKPGLYNPPYSAQSHP---- 210
P PG GP+ ES + T RP + K+ P + P + P
Sbjct: 117 PEIPGRGPLAESSDSGKKVPTPAPRP-----LLLKKSVSSENPTYPSAPLKPVTVPPRLA 171
Query: 211 -AAKTQTYRPLSKSHSDNSPN--------------AFKDASSPVP--------------- 240
A++ + Y+ L + N P +F D P P
Sbjct: 172 GASQAKAYKSLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVL 231
Query: 241 -PPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP 299
P +P P++ R P RK + ++P +P L E+P
Sbjct: 232 DPFQLPAKTEPIKERAVQPA-------PTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKP 284
Query: 300 ASLYQSSIDRSLERPMSSASMASDFRKRRKS---EPAVGPPRGLG------DQSASRTSP 350
S++ L + ++ S+ + P PPR + Q ++ P
Sbjct: 285 IGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPP 344
Query: 351 GRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT----PE 406
R P S T + P + S + D + + S+ T + ++ + + P
Sbjct: 345 ERPPPPKLSAT--RRSNKKLPFNRS-SSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPP 401
Query: 407 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE---GEHHGRVGIFPISYVEK 463
+ K P +Y + +GD + +L++ + N+ E GE GRV + + +
Sbjct: 402 RPK-PGHPLYS---------KYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITP 451
Query: 464 LTPPEKAQPARPPPPAQPGEIG--EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYE 521
L +++P P +P + G A+ ++F A+ +L+L G+ V LL+++D +WY
Sbjct: 452 LDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYR 511
Query: 522 GKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHE 581
G N+ GIFP +YV+V+ +G + H R
Sbjct: 512 GNC--RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRC---------------- 553
Query: 582 NIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSR-RTKFFGTFPGNY 640
A + Y +DEL E ++I + E ++ W G R RT G FP N+
Sbjct: 554 ---------VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRT---GIFPLNF 601
Query: 641 VK 642
V+
Sbjct: 602 VE 603
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 95.5 bits (236), Expect = 1e-19
Identities = 66/206 (32%), Positives = 106/206 (51%), Gaps = 26/206 (12%)
Query: 357 GSSTTLTKSFTS-SSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLP---- 411
GS T T + S SS + +KD +S + G PR + +P +P
Sbjct: 88 GSGTNCTNALRSQSSTVANCSSKDLQSSQ---------GGQQPRVQSWSPPVRGIPQLPC 138
Query: 412 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 471
AKA+Y+++ + +L F KGD + + R++D+NWY GE +G G FP ++V+ + P
Sbjct: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKP----- 193
Query: 472 PARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 531
P PP Q + + K + AD + L K D + +++RVD+NW EG + ++ G
Sbjct: 194 --LPQPPPQCKALYDFEVK-DKEADKDC-LPFAKDDVLTVIRRVDENWAEGML--ADKIG 247
Query: 532 IFPVSYVEVVKKNTKGAEDYPDPPIP 557
IFP+SYVE K ++ PP+P
Sbjct: 248 IFPISYVE-FNSAAKQLIEWDKPPVP 272
Score = 72.0 bits (175), Expect = 2e-12
Identities = 31/52 (59%), Positives = 37/52 (71%)
Query: 590 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 641
+ A+Y YTPR EDELELR+ ++ V E+C DGWF GTS T G FPGNYV
Sbjct: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
Score = 55.8 bits (133), Expect = 1e-07
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 588 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
E + + +Y P++E ELEL+E D++ V +K +DGWF GT +R G FPG++V+ +
Sbjct: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Score = 44.7 bits (104), Expect = 3e-04
Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 488 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 547
+A Y + EL LRKG+ ++ +R W++G T++ G+FP +YV V T+
Sbjct: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV---TRA 507
Query: 548 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 587
+ +P S + ++ P + +QG G
Sbjct: 508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
Score = 44.7 bits (104), Expect = 3e-04
Identities = 48/216 (22%), Positives = 85/216 (39%), Gaps = 46/216 (21%)
Query: 355 LPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM-GRSAPRERRGTPEKEKLPAK 413
LPG T+ S +S+ +S + D++S + L + G S R+ R +P PA
Sbjct: 686 LPGLPTS-PDSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSP-----PAS 739
Query: 414 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPI--------------- 458
+ + S EL + + G HGR G P+
Sbjct: 740 PTLEVELG-SAELPLQGA--------VGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAAL 790
Query: 459 ---SYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK------------YNFNADTNVELSL 503
++ K + + A P PPP +G + + ++ + EL L
Sbjct: 791 AQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELEL 850
Query: 504 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 539
++GD V + K+ + W++G + + G+FP S+VE
Sbjct: 851 KEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 44.7 bits (104), Expect = 3e-04
Identities = 18/54 (33%), Positives = 34/54 (62%), Gaps = 2/54 (3%)
Query: 413 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 464
+ V + Q+ EL K+GD V++ +K + W++G + +G+ G+FP S+VE +
Sbjct: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Score = 39.3 bits (90), Expect = 0.011
Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 2/54 (3%)
Query: 414 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLT 465
A+Y + + EL +KG+ + + W++G H ++G+FP +YV +T
Sbjct: 452 AIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
Score = 34.7 bits (78), Expect = 0.28
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 591 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
+ALYNY + +L+ + D+I + + D+ W+ G G FP N+V+
Sbjct: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHG--EVNGIHGFFPTNFVQ 189
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 90.9 bits (224), Expect = 3e-18
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%)
Query: 413 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 462
KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE
Sbjct: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
Query: 463 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 517
+L +K PA P+ G + ++ V R+ D K+
Sbjct: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381
Query: 518 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 572
+ ++R + + V + + + A D + H + +SS+
Sbjct: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439
Query: 573 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 620
P GE + ALY Y P+ DELEL + ++ V+EKC D
Sbjct: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499
Query: 621 GWFVGTSRRTKFFGTFPGNYV 641
GWF G S RT G FPGNYV
Sbjct: 500 GWFKGASLRTGVSGVFPGNYV 520
Score = 89.7 bits (221), Expect = 7e-18
Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%)
Query: 325 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 378
R R + P PP R + QSA+ T G PGS L+ + S++ S A
Sbjct: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183
Query: 379 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 438
R +P + + L G KA+Y ++ + +L F KGD + + R
Sbjct: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225
Query: 439 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 498
K+D+ WY GE HG G P SY++ + P A P + A Y+F
Sbjct: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272
Query: 499 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 554
+ L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D
Sbjct: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328
Query: 555 PIPHSYSS 562
P P + SS
Sbjct: 329 PCPAAASS 336
Score = 54.7 bits (130), Expect = 3e-07
Identities = 22/55 (40%), Positives = 39/55 (70%)
Query: 588 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+
Sbjct: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 51.2 bits (121), Expect = 3e-06
Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%)
Query: 367 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 413
+SS P + +R D ++ S ST T + R+A +GTP K +LP
Sbjct: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469
Query: 414 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 470
A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP +
Sbjct: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526
Query: 471 QPARPPPPAQPGEIGEAIAK 490
PP G +AK
Sbjct: 527 PAGGAGPPRNNVVGGSPLAK 546
Score = 50.8 bits (120), Expect = 4e-06
Identities = 67/290 (23%), Positives = 109/290 (37%), Gaps = 49/290 (16%)
Query: 205 SAQSHPAAKTQTYRP---LSKSHSDNSPNAFKDAS----SPVPPPHVPPPVPPLRPRDRS 257
S +H AA+ Q RP +S + NSP+ S S V P H P + PR
Sbjct: 608 STAAHSAAQAQD-RPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAI 666
Query: 258 --STEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPM 315
++ PP+ V E G +L P + ++ E+
Sbjct: 667 PLTSAASAITPPN--VSAANLNGEAGG------GPIGVLSTSSPTNTGCKLDEKKSEKKE 718
Query: 316 SSASM-----ASDFRKRRKSEPAVGPPR------------GLGDQSASRTSPGRVDLPGS 358
+ + + +K+ +S P+V P +G + +S + GR
Sbjct: 719 KKSGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRA----G 774
Query: 359 STTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT-PEKEKLPA---KA 414
S + + P K S T R AP PE + LP +
Sbjct: 775 SCPIESEMQGAMGMEPLHRK----AGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRV 830
Query: 415 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVE 462
V + Q+ E+ K+GD V++ +K + WY+G + +GR G+FP S+VE
Sbjct: 831 VVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 48.5 bits (114), Expect = 2e-05
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 446 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 495
E E G +G+ P+ S T P + P RP P P E + Y +
Sbjct: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838
Query: 496 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 539
+ +EL ++GD V + K+ + WY+G + R G+FP S+VE
Sbjct: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 39.7 bits (91), Expect = 0.009
Identities = 21/76 (27%), Positives = 34/76 (44%)
Query: 477 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 536
PP + +A Y + + EL L KG+ +L++ W++G T G+FP +
Sbjct: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518
Query: 537 YVEVVKKNTKGAEDYP 552
YV V + G P
Sbjct: 519 YVTPVSRVPAGGAGPP 534
Score = 34.3 bits (77), Expect = 0.37
Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 591 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
+ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 87.8 bits (216), Expect = 3e-17
Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 33/243 (13%)
Query: 418 FKAQTSKELSFKKGDTVYILRKID-QNWYEGEHHGRVGIFPISYVEKLTPP--------- 467
++AQ ELS GD V +R + + W GE GR G+FP V+++
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 468 -----EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEG 522
+ PA+ P P + ++ ++++ + EL L+ G+ V ++K ++ W+ G
Sbjct: 69 PRCARRRGHPAKHPRPQRWCKVN-----FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123
Query: 523 KIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI--PHSYSSDRIHSLSSNKPQRPVFTH 580
K G + G FP ++VE++ + PD P P ++ SL+ + P + T
Sbjct: 124 KKNG--QLGAFPSNFVELLDSGPPSLGN-PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
Query: 581 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPG 638
+ E ++ L++Y P DEL LR DV+ V+ K D GW+ G + + G FP
Sbjct: 181 SH----PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPD 234
Query: 639 NYV 641
N+V
Sbjct: 235 NFV 237
Score = 72.0 bits (175), Expect = 2e-12
Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 30/166 (18%)
Query: 401 RRGTPEKEKLP---AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 457
RRG P K P K + + + + EL + G+ V ++++I+ W+ G+ +G++G FP
Sbjct: 74 RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
Query: 458 ISYVEKLT--PPEKAQPARP---PPPAQPGEIGEAI------------------AKYNFN 494
++VE L PP P P P P +P ++ +++
Sbjct: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
Query: 495 ADTNVELSLRKGDRVILLKRV--DQNWYEGKIPGTNRQGIFPVSYV 538
+ EL+LR+GD V +L + D+ W+EG+ G R+G+FP ++V
Sbjct: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFV 237
Score = 59.7 bits (143), Expect = 8e-09
Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 22/160 (13%)
Query: 486 EAIAKYNFNADTNVELSLRKGDRVILLKRVD-QNWYEGKIPGTNRQGIFPVSYVEVVKKN 544
E + + A ELSL GD V ++ V + W G+ G R G+FP V+ + +
Sbjct: 2 EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
Query: 545 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDEL 604
+G+ + P R H +PQR + ++Y+P DEL
Sbjct: 60 LRGSGEARRPRCARR----RGHPAKHPRPQRWCKVN-------------FSYSPEQADEL 102
Query: 605 ELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
+L+ ++++++++ +DGW++G ++ G FP N+V+ L
Sbjct: 103 KLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
Score = 50.1 bits (118), Expect = 6e-06
Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 7/107 (6%)
Query: 370 SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFK 429
+P PS + + P SS D +P + T ++ + ++D++ + EL+ +
Sbjct: 149 NPDMPSVSPGPQRPPKLSSLAYD----SPPDYLQTVSHPEV-YRVLFDYQPEAPDELALR 203
Query: 430 KGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR 474
+GD V +L K D+ W+EGE GR G+FP ++V P +K P +
Sbjct: 204 RGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKLVPRK 250
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 87.0 bits (214), Expect = 5e-17
Identities = 83/290 (28%), Positives = 135/290 (46%), Gaps = 54/290 (18%)
Query: 374 PSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK-EKLPAKAVYDFKAQTSKELSFKKGD 432
PS + R+ +T T S+P G EK E L A+A+Y ++A+ L+F K D
Sbjct: 882 PSAGQLRQRSAFTPATATG---SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKND 938
Query: 433 TVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP----------EKAQPAR----PPPP 478
+ +L + D W+ GE G+ G FP SYV+ ++ P PA P
Sbjct: 939 VITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPA 997
Query: 479 AQPGEIGEA-IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSY 537
A+P GE IA Y + + +L+ ++GD VIL+ + D +W+ G + ++ G+FP +Y
Sbjct: 998 AKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKDGDWWTGTVG--DKAGVFPSNY 1054
Query: 538 VEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYT 597
V + K+++G S ++ + SL KP E Q + +YT
Sbjct: 1055 VRL--KDSEG-----------SGTAGKTGSLGK-KP--------------EIAQVIASYT 1086
Query: 598 PRNEDELELRESDVIDVMEKCDDGWFVGTSR---RTKFFGTFPGNYVKRL 644
++L L +I + +K GW+ G + + + G FP NYVK L
Sbjct: 1087 ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 84.7 bits (208), Expect = 2e-16
Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 33/232 (14%)
Query: 414 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 473
A+Y +++ +L+F++GD + + +K D +W+ G + G+FP +YV
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 474 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP--GTNRQ- 530
+ + EI + IA Y A +L+L G +++ K+ W+EG++ G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYT--ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 531 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF 590
G FP +YV+++ T ++ +P + Q G
Sbjct: 1126 GWFPANYVKLLSPGTS--------------------KITPTEPPKSTALAAVCQVIG--- 1162
Query: 591 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
+Y+YT +N+DEL + +I+V+ K D W+ G G FP NYVK
Sbjct: 1163 --MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ--VGLFPSNYVK 1210
Score = 75.5 bits (184), Expect = 1e-13
Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 390 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 449
L D S + G+ K+ A+ + + A ++L+ G + I +K W+EGE
Sbjct: 1057 LKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGEL 1116
Query: 450 HGR-----VGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL 503
R +G FP +YV+ L+P K P PP + + I Y++ A + EL+
Sbjct: 1117 QARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF 1176
Query: 504 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 540
KG + +L + D +W++G++ G + G+FP +YV++
Sbjct: 1177 NKGQIINVLNKEDPDWWKGEVNG--QVGLFPSNYVKL 1211
Score = 57.8 bits (138), Expect = 3e-08
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 415 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 471
+YD+ AQ EL+F KG + +L K D +W++GE +G+VG+FP +YV+ T + +Q
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 55.5 bits (132), Expect = 2e-07
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 34/243 (13%)
Query: 413 KAVYDFKAQTSKELSFKKGDTVYILRK-IDQN------WYEGEHHGRVGIFPISYVEKLT 465
+A+Y F++++ E++ + GD V + + +D++ W GE G+ G FP +Y EK+
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 466 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 525
E P +P + + + +T L++ + NW
Sbjct: 806 ENEVPAPVKPVTDSTSAPAPKLALR-----ETPAPLAVTSSEP----STTPNNW------ 850
Query: 526 GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHEN-IQ 584
+ +P S E K T + + P S+ ++ S+ P + + +
Sbjct: 851 -ADFSSTWPTSTNE--KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL 907
Query: 585 GGGEPF-----QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 639
G GE QALY + + ++ L ++DVI V+E+ D WF G + K G FP +
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQK--GWFPKS 964
Query: 640 YVK 642
YVK
Sbjct: 965 YVK 967
Score = 32.0 bits (71), Expect = 1.8
Identities = 16/62 (25%), Positives = 31/62 (50%), Gaps = 9/62 (14%)
Query: 590 FQALYNYTPRNEDELELRESDV-------IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
++ALY + R+ DE+ ++ D+ +D + + GW G + G FP NY +
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT--GWFPANYAE 802
Query: 643 RL 644
++
Sbjct: 803 KI 804
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 87.0 bits (214), Expect = 5e-17
Identities = 83/290 (28%), Positives = 135/290 (46%), Gaps = 54/290 (18%)
Query: 374 PSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK-EKLPAKAVYDFKAQTSKELSFKKGD 432
PS + R+ +T T S+P G EK E L A+A+Y ++A+ L+F K D
Sbjct: 882 PSAGQLRQRSAFTPATATG---SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKND 938
Query: 433 TVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP----------EKAQPAR----PPPP 478
+ +L + D W+ GE G+ G FP SYV+ ++ P PA P
Sbjct: 939 VITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPA 997
Query: 479 AQPGEIGEA-IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSY 537
A+P GE IA Y + + +L+ ++GD VIL+ + D +W+ G + ++ G+FP +Y
Sbjct: 998 AKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKDGDWWTGTVG--DKAGVFPSNY 1054
Query: 538 VEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYT 597
V + K+++G S ++ + SL KP E Q + +YT
Sbjct: 1055 VRL--KDSEG-----------SGTAGKTGSLGK-KP--------------EIAQVIASYT 1086
Query: 598 PRNEDELELRESDVIDVMEKCDDGWFVGTSR---RTKFFGTFPGNYVKRL 644
++L L +I + +K GW+ G + + + G FP NYVK L
Sbjct: 1087 ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 84.7 bits (208), Expect = 2e-16
Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 33/232 (14%)
Query: 414 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 473
A+Y +++ +L+F++GD + + +K D +W+ G + G+FP +YV
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 474 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP--GTNRQ- 530
+ + EI + IA Y A +L+L G +++ K+ W+EG++ G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYT--ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 531 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF 590
G FP +YV+++ T ++ +P + Q G
Sbjct: 1126 GWFPANYVKLLSPGTS--------------------KITPTEPPKSTALAAVCQVIG--- 1162
Query: 591 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
+Y+YT +N+DEL + +I+V+ K D W+ G G FP NYVK
Sbjct: 1163 --MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ--VGLFPSNYVK 1210
Score = 75.5 bits (184), Expect = 1e-13
Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 390 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 449
L D S + G+ K+ A+ + + A ++L+ G + I +K W+EGE
Sbjct: 1057 LKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGEL 1116
Query: 450 HGR-----VGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL 503
R +G FP +YV+ L+P K P PP + + I Y++ A + EL+
Sbjct: 1117 QARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF 1176
Query: 504 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 540
KG + +L + D +W++G++ G + G+FP +YV++
Sbjct: 1177 NKGQIINVLNKEDPDWWKGEVNG--QVGLFPSNYVKL 1211
Score = 57.8 bits (138), Expect = 3e-08
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 415 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 471
+YD+ AQ EL+F KG + +L K D +W++GE +G+VG+FP +YV+ T + +Q
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 55.5 bits (132), Expect = 2e-07
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 34/243 (13%)
Query: 413 KAVYDFKAQTSKELSFKKGDTVYILRK-IDQN------WYEGEHHGRVGIFPISYVEKLT 465
+A+Y F++++ E++ + GD V + + +D++ W GE G+ G FP +Y EK+
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 466 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 525
E P +P + + + +T L++ + NW
Sbjct: 806 ENEVPAPVKPVTDSTSAPAPKLALR-----ETPAPLAVTSSEP----STTPNNW------ 850
Query: 526 GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHEN-IQ 584
+ +P S E K T + + P S+ ++ S+ P + + +
Sbjct: 851 -ADFSSTWPTSTNE--KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL 907
Query: 585 GGGEPF-----QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 639
G GE QALY + + ++ L ++DVI V+E+ D WF G + K G FP +
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQK--GWFPKS 964
Query: 640 YVK 642
YVK
Sbjct: 965 YVK 967
Score = 32.0 bits (71), Expect = 1.8
Identities = 16/62 (25%), Positives = 31/62 (50%), Gaps = 9/62 (14%)
Query: 590 FQALYNYTPRNEDELELRESDV-------IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
++ALY + R+ DE+ ++ D+ +D + + GW G + G FP NY +
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT--GWFPANYAE 802
Query: 643 RL 644
++
Sbjct: 803 KI 804
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 84.0 bits (206), Expect = 4e-16
Identities = 94/372 (25%), Positives = 153/372 (41%), Gaps = 67/372 (18%)
Query: 329 KSEPAVGPPRGL--GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSY 386
++E AV P + L S S TS L + + + S S+ + + ++
Sbjct: 793 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 852
Query: 387 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 446
+ T++ G +P +G E L A+A+ + A+ L+F K D + +L + +NW+
Sbjct: 853 TRTVSP-GSVSPIHGQGQVV-ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWF 909
Query: 447 GEHHGRVGIFPISYVEKLTPPEKAQPARPP---------PPAQPGEIGEA-IAKYNFNAD 496
GE HG G FP SYV K+ P + + P P + +GE IA Y +++
Sbjct: 910 GEVHGGRGWFPKSYV-KIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSV 968
Query: 497 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDY 551
+L+ +G+ +++ ++ D W+ G I +R GIFP +YV E +K
Sbjct: 969 EPGDLTFTEGEEILVTQK-DGEWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASN 1025
Query: 552 PDPPIPH---SYSSDRIHSLSSNKPQRPVFTHEN--------IQGGGEPFQ--------- 591
P I +Y + LS Q + +N +Q G+ Q
Sbjct: 1026 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1085
Query: 592 ---------------------ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRT 630
A+Y+Y NEDEL + +I+VM K D W+ G
Sbjct: 1086 KLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV 1145
Query: 631 KFFGTFPGNYVK 642
G FP NYVK
Sbjct: 1146 T--GLFPSNYVK 1155
Score = 74.3 bits (181), Expect = 3e-13
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 36/220 (16%)
Query: 371 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 430
PS+ + KD+ES S S + G K+ A+ + A S++LS
Sbjct: 1003 PSNYVKPKDQESFGSASKS-------------GASNKKPEIAQVTSAYVASGSEQLSLAP 1049
Query: 431 GDTVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEI 484
G + IL+K W++GE R G FP S+V+ L P E+A PA P +
Sbjct: 1050 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------V 1102
Query: 485 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 544
+ IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1103 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS 1160
Query: 545 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 584
DP + ++ + +R + HE IQ
Sbjct: 1161 --------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1192
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 356 PGSSTTLTKSFTSS--SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PA 412
PG + K TS +R K R+ +S + +G P R TP +
Sbjct: 1049 PGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG---PSSERATPAFHPVCQV 1105
Query: 413 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 471
A+YD+ A ELSF KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1106 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1164
Score = 46.6 bits (109), Expect = 7e-05
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 413 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 470
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
Query: 471 QPARPPPPAQP 481
+ P P
Sbjct: 796 KAVSPKKALLP 806
Score = 43.9 bits (102), Expect = 5e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 590 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 644
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 735 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 789
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 84.0 bits (206), Expect = 4e-16
Identities = 94/372 (25%), Positives = 153/372 (41%), Gaps = 67/372 (18%)
Query: 329 KSEPAVGPPRGL--GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSY 386
++E AV P + L S S TS L + + + S S+ + + ++
Sbjct: 820 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 879
Query: 387 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 446
+ T++ G +P +G E L A+A+ + A+ L+F K D + +L + +NW+
Sbjct: 880 TRTVSP-GSVSPIHGQGQVV-ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWF 936
Query: 447 GEHHGRVGIFPISYVEKLTPPEKAQPARPP---------PPAQPGEIGEA-IAKYNFNAD 496
GE HG G FP SYV K+ P + + P P + +GE IA Y +++
Sbjct: 937 GEVHGGRGWFPKSYV-KIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSV 995
Query: 497 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDY 551
+L+ +G+ +++ ++ D W+ G I +R GIFP +YV E +K
Sbjct: 996 EPGDLTFTEGEEILVTQK-DGEWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASN 1052
Query: 552 PDPPIPH---SYSSDRIHSLSSNKPQRPVFTHEN--------IQGGGEPFQ--------- 591
P I +Y + LS Q + +N +Q G+ Q
Sbjct: 1053 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1112
Query: 592 ---------------------ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRT 630
A+Y+Y NEDEL + +I+VM K D W+ G
Sbjct: 1113 KLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV 1172
Query: 631 KFFGTFPGNYVK 642
G FP NYVK
Sbjct: 1173 T--GLFPSNYVK 1182
Score = 74.3 bits (181), Expect = 3e-13
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 36/220 (16%)
Query: 371 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 430
PS+ + KD+ES S S + G K+ A+ + A S++LS
Sbjct: 1030 PSNYVKPKDQESFGSASKS-------------GASNKKPEIAQVTSAYVASGSEQLSLAP 1076
Query: 431 GDTVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEI 484
G + IL+K W++GE R G FP S+V+ L P E+A PA P +
Sbjct: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------V 1129
Query: 485 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 544
+ IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1130 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS 1187
Query: 545 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 584
DP + ++ + +R + HE IQ
Sbjct: 1188 --------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1219
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 356 PGSSTTLTKSFTSS--SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PA 412
PG + K TS +R K R+ +S + +G P R TP +
Sbjct: 1076 PGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG---PSSERATPAFHPVCQV 1132
Query: 413 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 471
A+YD+ A ELSF KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Score = 46.6 bits (109), Expect = 7e-05
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 413 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 470
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 471 QPARPPPPAQP 481
+ P P
Sbjct: 823 KAVSPKKALLP 833
Score = 43.9 bits (102), Expect = 5e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 590 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 644
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 816
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 84.0 bits (206), Expect = 4e-16
Identities = 94/372 (25%), Positives = 153/372 (41%), Gaps = 67/372 (18%)
Query: 329 KSEPAVGPPRGL--GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSY 386
++E AV P + L S S TS L + + + S S+ + + ++
Sbjct: 820 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 879
Query: 387 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 446
+ T++ G +P +G E L A+A+ + A+ L+F K D + +L + +NW+
Sbjct: 880 TRTVSP-GSVSPIHGQGQVV-ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWF 936
Query: 447 GEHHGRVGIFPISYVEKLTPPEKAQPARPP---------PPAQPGEIGEA-IAKYNFNAD 496
GE HG G FP SYV K+ P + + P P + +GE IA Y +++
Sbjct: 937 GEVHGGRGWFPKSYV-KIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSV 995
Query: 497 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDY 551
+L+ +G+ +++ ++ D W+ G I +R GIFP +YV E +K
Sbjct: 996 EPGDLTFTEGEEILVTQK-DGEWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASN 1052
Query: 552 PDPPIPH---SYSSDRIHSLSSNKPQRPVFTHEN--------IQGGGEPFQ--------- 591
P I +Y + LS Q + +N +Q G+ Q
Sbjct: 1053 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1112
Query: 592 ---------------------ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRT 630
A+Y+Y NEDEL + +I+VM K D W+ G
Sbjct: 1113 KLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV 1172
Query: 631 KFFGTFPGNYVK 642
G FP NYVK
Sbjct: 1173 T--GLFPSNYVK 1182
Score = 74.3 bits (181), Expect = 3e-13
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 36/220 (16%)
Query: 371 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 430
PS+ + KD+ES S S + G K+ A+ + A S++LS
Sbjct: 1030 PSNYVKPKDQESFGSASKS-------------GASNKKPEIAQVTSAYVASGSEQLSLAP 1076
Query: 431 GDTVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEI 484
G + IL+K W++GE R G FP S+V+ L P E+A PA P +
Sbjct: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------V 1129
Query: 485 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 544
+ IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1130 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS 1187
Query: 545 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 584
DP + ++ + +R + HE IQ
Sbjct: 1188 --------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1219
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 356 PGSSTTLTKSFTSS--SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PA 412
PG + K TS +R K R+ +S + +G P R TP +
Sbjct: 1076 PGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG---PSSERATPAFHPVCQV 1132
Query: 413 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 471
A+YD+ A ELSF KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Score = 46.6 bits (109), Expect = 7e-05
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 413 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 470
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 471 QPARPPPPAQP 481
+ P P
Sbjct: 823 KAVSPKKALLP 833
Score = 43.9 bits (102), Expect = 5e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 590 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 644
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 816
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 83.2 bits (204), Expect = 7e-16
Identities = 53/165 (32%), Positives = 96/165 (58%), Gaps = 12/165 (7%)
Query: 488 IAKYNFNADTNVELSLRKGDRVILLKRV-DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 546
I +Y+++A + EL++R G+ + +K++ ++ W EG++ G R+G+FP ++V+ +K+ T+
Sbjct: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRETE 62
Query: 547 GAED-YPDPPIPHSYSSDRIHSLSS-NKPQRPVFTH---ENIQGGGEPFQA--LYNYTPR 599
+D P H + + +S+ P + H +NI+ + Q L+ Y P+
Sbjct: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQ 122
Query: 600 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
NEDELEL+ D+ID+ E+ ++GW+ GT G FP N+VK L
Sbjct: 123 NEDELELKVGDIIDINEEVEEGWWSGTLNNK--LGLFPSNFVKEL 165
Score = 55.8 bits (133), Expect = 1e-07
Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 100/325 (30%)
Query: 416 YDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHHGRVGIFPISYVEKL-TPPEKAQPA 473
YD+ A EL+ + G+ + ++K+ ++ W EGE +GR G+FP ++V+++ E +
Sbjct: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
Query: 474 RPPPPAQPGEIGEAIAK--------------------------------YNFNADTNVEL 501
P + G + + + + + EL
Sbjct: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
Query: 502 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG----AED------- 550
L+ GD + + + V++ W+ G + N+ G+FP ++V+ ++ G A+D
Sbjct: 128 ELKVGDIIDINEEVEEGWWSGTL--NNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLA 185
Query: 551 YPDPPIP---------------------------HSYSSDRIHSLSSN------KPQRPV 577
P PIP S ++ + +S+ KP++P+
Sbjct: 186 GPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPL 245
Query: 578 -------------FTHENIQG---GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CD 619
T + +G E + L+ Y NEDEL +E ++I ++ K +
Sbjct: 246 ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
Query: 620 DGWFVGTSRRTKFFGTFPGNYVKRL 644
GW+ G + G FP N+ ++
Sbjct: 306 AGWWRGELNGKE--GVFPDNFAVQI 328
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 5/88 (5%)
Query: 407 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKL 464
K K + ++ ++ EL+FK+G+ ++++ K + W+ GE +G+ G+FP ++ ++
Sbjct: 269 KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
Query: 465 TPPEK--AQPARPPPPAQ-PGEIGEAIA 489
+K +P +PPPPA+ P E IA
Sbjct: 329 NELDKDFPKPKKPPPPAKAPAPKPELIA 356
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 82.8 bits (203), Expect = 9e-16
Identities = 50/162 (30%), Positives = 90/162 (55%), Gaps = 12/162 (7%)
Query: 486 EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNT 545
EAI ++++ A + EL++ G+ + +++ D W+EG+I G R+G+FP ++V +KK
Sbjct: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
Query: 546 KG---AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 602
K P+ P+ S + + LSS R T++ + Q ++Y P+N+D
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSL--LSSETILR---TNKRGERRRRRCQVAFSYLPQNDD 115
Query: 603 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
ELEL+ D+I+V+ + ++GW+ G G FP N++K L
Sbjct: 116 ELELKVGDIIEVVGEVEEGWWEGVLNGKT--GMFPSNFIKEL 155
Score = 66.2 bits (160), Expect = 9e-11
Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)
Query: 407 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 464
K K K ++ ++AQ EL+ K+GD V ++ K ID W+EGE +GR G+FP ++V KL
Sbjct: 267 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 325
Query: 465 TPP----EKAQPARPPPPAQP 481
PP E +P +PPPP+ P
Sbjct: 326 LPPDFEKEGNRPKKPPPPSAP 346
Score = 63.5 bits (153), Expect = 6e-10
Identities = 37/148 (25%), Positives = 73/148 (49%), Gaps = 26/148 (17%)
Query: 416 YDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARP 475
+D++AQ EL+ G+ + +RK D W+EG+ +GR G+FP ++V ++ K P
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67
Query: 476 PPPAQP-------------------GEIGEAIAK-----YNFNADTNVELSLRKGDRVIL 511
P +P + GE + +++ + EL L+ GD + +
Sbjct: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127
Query: 512 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 539
+ V++ W+EG + G + G+FP ++++
Sbjct: 128 VGEVEEGWWEGVLNG--KTGMFPSNFIK 153
Score = 62.4 bits (150), Expect = 1e-09
Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)
Query: 367 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 426
T+ +P P + S T+ + R RR + + + Q EL
Sbjct: 66 TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 117
Query: 427 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 486
K GD + ++ ++++ W+EG +G+ G+FP +++++L+ + E
Sbjct: 118 ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 177
Query: 487 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 546
+ D++ S +G + Q K+ G IF +++ ++ +
Sbjct: 178 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 232
Query: 547 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 606
D+ +P + + ++ P ++ + + ++ Y +N+DEL +
Sbjct: 233 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 288
Query: 607 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 644
+E D++ ++ K D GW+ G + G FP N+VK L
Sbjct: 289 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)
Query: 491 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 548
+ + A + EL++++GD V L+ + +D W+EG++ G R+G+FP ++V+++ + +
Sbjct: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 333
Query: 549 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 600
+ P P P S +++R H + P+RP P + P
Sbjct: 334 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 384
Query: 601 EDELELRESDV 611
E +L+L++ V
Sbjct: 385 EPKLDLQKPSV 395
Score = 34.7 bits (78), Expect = 0.28
Identities = 45/189 (23%), Positives = 79/189 (41%), Gaps = 17/189 (8%)
Query: 229 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWD--PPDRKVDTRKFRSEPRSIFEY 286
P+ K+ + P PP PP P ++ ++ KH+ PP+R + R+E + E
Sbjct: 328 PDFEKEGNRPKKPP--PPSAPVIKQGAGTTERKHEIKKIPPERP-EMLPNRTEEKERPER 384
Query: 287 EPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS 346
EP K + + PA I RP + S++ R + P P R +G + +
Sbjct: 385 EP-KLDLQKPSVPA------IPPKKPRPPKTNSLS-----RPGALPPRRPERPVGPLTHT 432
Query: 347 RTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPE 406
R ++DL GSS + S S+ + +S S + L+ S P+ P
Sbjct: 433 RGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPP 492
Query: 407 KEKLPAKAV 415
+ L + ++
Sbjct: 493 SQSLTSSSL 501
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,356,117
Number of Sequences: 37866
Number of extensions: 1690469
Number of successful extensions: 14867
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 279
Number of HSP's successfully gapped in prelim test: 524
Number of HSP's that attempted gapping in prelim test: 10842
Number of HSP's gapped (non-prelim): 3738
length of query: 644
length of database: 18,247,518
effective HSP length: 109
effective length of query: 535
effective length of database: 14,120,124
effective search space: 7554266340
effective search space used: 7554266340
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.