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Search of human proteins with 224458288
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224458288 lipoxygenase homology domains 1 isoform 2 [Homo
sapiens]
(1114 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224458288 lipoxygenase homology domains 1 isoform 2 [Homo sap... 2296 0.0
gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo sap... 2073 0.0
gi|224458290 lipoxygenase homology domains 1 isoform 3 [Homo sap... 933 0.0
gi|239754889 PREDICTED: similar to hCG2036697 [Homo sapiens] 108 4e-23
gi|239749428 PREDICTED: hypothetical protein XP_002347033 [Homo ... 108 4e-23
gi|239743562 PREDICTED: hypothetical protein XP_002342894 [Homo ... 108 4e-23
gi|19923084 polycystin-1L1 [Homo sapiens] 79 2e-14
gi|239756622 PREDICTED: polycystic kidney disease 1-like 3 [Homo... 79 2e-14
gi|239751108 PREDICTED: polycystic kidney disease 1-like 3 [Homo... 79 2e-14
gi|239745596 PREDICTED: polycystin 1-like 3 [Homo sapiens] 79 2e-14
gi|31559825 polycystin 1-like 3 [Homo sapiens] 79 2e-14
gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens] 76 2e-13
gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens] 75 3e-13
gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens] 75 3e-13
gi|5174633 receptor for egg jelly-like protein precursor [Homo s... 70 1e-11
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 66 2e-10
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 62 4e-09
gi|4502057 arachidonate 5-lipoxygenase [Homo sapiens] 47 8e-05
gi|4502053 arachidonate 12-lipoxygenase, 12R type [Homo sapiens] 44 9e-04
gi|40316937 arachidonate 15-lipoxygenase [Homo sapiens] 42 0.003
gi|154426292 arachidonate 12-lipoxygenase [Homo sapiens] 42 0.003
gi|182765464 arachidonate lipoxygenase 3 [Homo sapiens] 37 0.10
gi|85067503 arachidonate 15-lipoxygenase, second type isoform b ... 31 5.7
gi|85067499 arachidonate 15-lipoxygenase, second type isoform a ... 31 5.7
gi|85067501 arachidonate 15-lipoxygenase, second type isoform d ... 31 5.7
gi|169218320 PREDICTED: similar to BCL2-associated transcription... 31 7.5
gi|117938254 BCL2-associated transcription factor 1 isoform 3 [H... 31 7.5
gi|117938251 BCL2-associated transcription factor 1 isoform 2 [H... 31 7.5
gi|7661958 BCL2-associated transcription factor 1 isoform 1 [Hom... 31 7.5
gi|118918395 fibronectin type III domain containing 3A isoform 1... 30 9.8
>gi|224458288 lipoxygenase homology domains 1 isoform 2 [Homo sapiens]
Length = 1114
Score = 2296 bits (5949), Expect = 0.0
Identities = 1114/1114 (100%), Positives = 1114/1114 (100%)
Query: 1 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQK 60
MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQK
Sbjct: 1 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQK 60
Query: 61 DKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTV 120
DKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTV
Sbjct: 61 DKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTV 120
Query: 121 ETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRD 180
ETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRD
Sbjct: 121 ETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRD 180
Query: 181 LFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQK 240
LFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQK
Sbjct: 181 LFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQK 240
Query: 241 QFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTF 300
QFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTF
Sbjct: 241 QFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTF 300
Query: 301 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 360
PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI
Sbjct: 301 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 360
Query: 361 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 420
PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH
Sbjct: 361 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 420
Query: 421 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCS 480
DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCS
Sbjct: 421 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCS 480
Query: 481 SPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFL 540
SPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFL
Sbjct: 481 SPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFL 540
Query: 541 IGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPESCWLVEE 600
IGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPESCWLVEE
Sbjct: 541 IGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPESCWLVEE 600
Query: 601 LCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVWTGDVVG 660
LCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVWTGDVVG
Sbjct: 601 LCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVWTGDVVG 660
Query: 661 GGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGS 720
GGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGS
Sbjct: 661 GGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGS 720
Query: 721 RPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAV 780
RPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAV
Sbjct: 721 RPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAV 780
Query: 781 KTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCK 840
KTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCK
Sbjct: 781 KTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCK 840
Query: 841 LRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKICD 900
LRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKICD
Sbjct: 841 LRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKICD 900
Query: 901 ELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDS 960
ELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDS
Sbjct: 901 ELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDS 960
Query: 961 IYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKY 1020
IYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKY
Sbjct: 961 IYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKY 1020
Query: 1021 FKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELK 1080
FKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELK
Sbjct: 1021 FKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELK 1080
Query: 1081 QKMRNLFERGSTDRFFLETLELVVTRLGLAAECG 1114
QKMRNLFERGSTDRFFLETLELVVTRLGLAAECG
Sbjct: 1081 QKMRNLFERGSTDRFFLETLELVVTRLGLAAECG 1114
>gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo sapiens]
Length = 2211
Score = 2073 bits (5372), Expect = 0.0
Identities = 1023/1102 (92%), Positives = 1026/1102 (93%), Gaps = 62/1102 (5%)
Query: 1 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQK 60
MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQK
Sbjct: 1112 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQK 1171
Query: 61 DKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTV 120
DKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTV
Sbjct: 1172 DKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTV 1231
Query: 121 ETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRD 180
ETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRD
Sbjct: 1232 ETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRD 1291
Query: 181 LFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQK 240
LFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQK
Sbjct: 1292 LFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQK 1351
Query: 241 QFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTF 300
QFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTF
Sbjct: 1352 QFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTF 1411
Query: 301 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 360
PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI
Sbjct: 1412 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 1471
Query: 361 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 420
PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH
Sbjct: 1472 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 1531
Query: 421 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCS 480
DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCS
Sbjct: 1532 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCS 1591
Query: 481 SPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFL 540
SPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFL
Sbjct: 1592 SPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFL 1651
Query: 541 IGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPESCWLVEE 600
IGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIE+
Sbjct: 1652 IGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIEV--------------- 1696
Query: 601 LCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVWTGDVVG 660
+ W G G S +F
Sbjct: 1697 ------------LYEMTVWTGDVVGGGTDSNIF--------------------------- 1717
Query: 661 GGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGS 720
MTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGS
Sbjct: 1718 --------MTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGS 1769
Query: 721 RPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAV 780
RPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAV
Sbjct: 1770 RPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAV 1829
Query: 781 KTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCK 840
KTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCK
Sbjct: 1830 KTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCK 1889
Query: 841 LRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKICD 900
LRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKICD
Sbjct: 1890 LRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKICD 1949
Query: 901 ELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDS 960
ELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDS
Sbjct: 1950 ELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDS 2009
Query: 961 IYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKY 1020
IYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKY
Sbjct: 2010 IYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKY 2069
Query: 1021 FKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELK 1080
FKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELK
Sbjct: 2070 FKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELK 2129
Query: 1081 QKMRNLFERGSTDRFFLETLEL 1102
QKMRNLFERGSTDRFFLETLEL
Sbjct: 2130 QKMRNLFERGSTDRFFLETLEL 2151
Score = 423 bits (1088), Expect = e-118
Identities = 336/1240 (27%), Positives = 556/1240 (44%), Gaps = 197/1240 (15%)
Query: 3 NEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDK 62
N+ Y F C RWL EDD ++ RE+ + EG + +
Sbjct: 514 NKDKYNFNCNRWLDANEDDNEIVREM-----------TAEGP-----------TVRRIMG 551
Query: 63 STTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVET 122
+ VT+ TG + AGTDANV++ LFG DTG LL + + N+D FE+ + + FT+E+
Sbjct: 552 MARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIES 611
Query: 123 LDLGDLWKVRLGHDNTGKAPGWFVDWVEV--DAPSLGKCMTFPCGRWLAKNEDDGSIIRD 180
+ + ++ +VR+ HD G GW++D V V + + FPC RWL K++DDG ++R+
Sbjct: 612 VTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRE 671
Query: 181 LFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQK 240
L ++ L Y I+L T DV A TD+ ++I +YG D T ++ L + K
Sbjct: 672 LLPSDSSATLKN--FRYHISLKTGDVSGASTDSRVYIKLYG-DKSDTIKQVLLVSDNNLK 728
Query: 241 QFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTF 300
+FER F +E ++G I ++ IGH++TGM+ W V IR +P + + TF
Sbjct: 729 DYFERGRVDEFTLETLNIGNI-NRLVIGHDSTGMHASWFLGSVQIR--VPRQ--GKQYTF 783
Query: 301 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 360
P +RWL ++ D + EL P EV E +V Y V+I+TG++
Sbjct: 784 PANRWLDKNQADGRLEVELYP------------------SEVVEIQKLVHYEVEIWTGDV 825
Query: 361 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 420
GAGT A+VY+ IYG+ G T +L +R+ FER + DTF +EAAD+G +YK++L H
Sbjct: 826 GGAGTSARVYMQIYGEKGKTEVLFLS---SRSKVFERASKDTFQLEAADVGEVYKLRLGH 882
Query: 421 DNSKWCADWYVEKV----------------EIWNDTNEDEFLFLCGRW-LSLKKEDGRLE 463
+ W+V+ V E +D+ L + L K + + +
Sbjct: 883 TGEGFGPSWFVDTVWLRHLVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKK 942
Query: 464 RLFYEKEYTGDRSSNCSSPADFWEIALSSKMADVDISTVTGP-MADYVQEGP-------- 514
R ++E G+ + SS E +M + + GP M + +++
Sbjct: 943 RKGSDEEDEGEEEESSSSEESSSE---EEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLA 999
Query: 515 -----------IIP----------YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWL 553
++P Y V V TG A TD+ ++ + GE+ + L
Sbjct: 1000 RGKEDNELVVELVPAGKPGPERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPL 1059
Query: 554 DYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYM 613
F +G + F + +D+G + KI + HD + W ++ + + Y
Sbjct: 1060 KKSDKSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYY 1119
Query: 614 LNCNCWLAKDRGDGITSRVFDLLDAMVV-----------------NIGVK-----VLYEM 651
C WLA + DG SR +D V N+ ++ + +
Sbjct: 1120 FPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKSTTFSV 1179
Query: 652 TVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKA---RFEREQNDTFIMEILDIAPF 708
T+ TG GTD+N+F+TL+G T L K +FER+ + F +E LD+
Sbjct: 1180 TIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDL 1239
Query: 709 TKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMC-AVIDE 767
K+R+ D G P WF++ + + + G F G WL++ + +++ ++ A +
Sbjct: 1240 WKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAELQT 1299
Query: 768 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENG---DSGTLALKQSANWNKFERNNT 824
+ Y + + TSD+ AGTDAN+FIII+G + L + FER +
Sbjct: 1300 RLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSA 1359
Query: 825 DTFNFPDMLSLGHLC-KLRVWHDNKGIFPGWHLSYVDVK----DNSRDETFHFQCDCWLS 879
F ++ +G + K+R+ H+N G+ PGWH S+VD++ D ET F CD WL+
Sbjct: 1360 SRF-IVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLA 1418
Query: 880 KSEGDGQTVRDFACAN------------NKICDELEE----TTYEIVIETGN--GGETRE 921
SE D +T+R+ + ++ E+EE Y + I TGN G T
Sbjct: 1419 TSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNIPGAGTDA 1478
Query: 922 NVWLILEGRKNRSKE-FLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRF 980
V++ + G + E +L ++ +R F +GT DTF ++ LG I + + H D
Sbjct: 1479 KVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH----DN- 1533
Query: 981 IPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKR-----KRKYFKV------------ 1023
K W+V+ + I + + F C + LK+ +R +++
Sbjct: 1534 -SKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCSS 1592
Query: 1024 ---------------FEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIF 1068
+++ T A VQ + Y V VTTG A TD+ F+ +
Sbjct: 1593 PADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFLI 1652
Query: 1069 GANGDTGKRELKQKMRNL--FERGSTDRFFLETLELVVTR 1106
G + + KR R F RGS + F++ L++ + +
Sbjct: 1653 GEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIK 1692
Score = 378 bits (971), Expect = e-104
Identities = 290/951 (30%), Positives = 451/951 (47%), Gaps = 104/951 (10%)
Query: 62 KSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVE 121
K+ + V TG + AGTDANVFITLFG ++ L +SK+ S FE+ ++++F V
Sbjct: 41 KARVYEVVTATGDVRGAGTDANVFITLFG-ENGLSPKLQLTSKSKS-AFEKGNVDVFRVR 98
Query: 122 TLDLGDLWKVRLGHDNTGKAPGWFVDWVEV-DAPSLGKCMTFPCGRWLAKNEDDGSIIRD 180
T ++G ++KVR+ HDNTG W++D V V D F C WL+K E D RD
Sbjct: 99 TNNVGLIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRD 158
Query: 181 LFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKR--- 237
L A YE+ +YT DV AGTDA++FI I+G +Y T +R
Sbjct: 159 LL-ASFNPMDMPRGNKYEVKVYTGDVIGAGTDADVFINIFG--------EYGDTGERRLE 209
Query: 238 EQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAET 297
+K FE+ + RFI++ D+G+++ KI +GHNN G + GW S + ++ D
Sbjct: 210 NEKDNFEKGAEDRFILDAPDLGQLM-KINVGHNNKGGSAGWFLSQI----VIEDIGNKRK 264
Query: 298 LTFPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFT 357
FP +RWLA EDD K R+++ T + Y V +FT
Sbjct: 265 YDFPLNRWLALDEDDGKIQRDILVGGAET--------------------TAITYIVTVFT 304
Query: 358 GNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIE-AADLGVIYKI 416
G++ GAGT +K+Y+ +YG G+ GK F+RG D F IE A L + ++
Sbjct: 305 GDVRGAGTKSKIYLVMYGARGNKNS---GKIFLEGGVFDRGRTDIFHIELAVLLSPLSRV 361
Query: 417 KLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRS 476
+ H N W+ EKV I + F C WL KK DG +ER YE
Sbjct: 362 SVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEM------- 414
Query: 477 SNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRA 536
++L K P+ + V T K A T+S
Sbjct: 415 -----------VSLRKKRLKK------------------FPWSLWVWTTDLKKAGTNSPI 445
Query: 537 FIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPESCW 596
FI + G+ R+ I L+ P K F G +E+F + D+G KI + HD S S W
Sbjct: 446 FIQIYGQKG-RTDEILLN-PNNK-WFKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGW 502
Query: 597 LVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVWTG 656
+E + L KY NCN WL + D R V I Y +TV TG
Sbjct: 503 HLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAEGPTVRRIMGMARYHVTVCTG 562
Query: 657 DVVGGGTDSNIFMTLYGINGSTEEMQLDKKKAR---FEREQNDTFIMEILDIAPFTKMRI 713
++ G GTD+N+++ L+G G T E L + FE+ D F +E + + ++RI
Sbjct: 563 ELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRNVRRVRI 622
Query: 714 RIDGLGSRPEWFLERILLK--NMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMM 771
R DG GS W+L+R+L++ D F WL + K LV E+ D +
Sbjct: 623 RHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELLP-SDSSATL 681
Query: 772 EWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNK--FERNNTDTFNF 829
+ Y +++KT D+ GA TD+ V+I ++G+ D+ L S N K FER D F
Sbjct: 682 KNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLKDYFERGRVDEFTL 741
Query: 830 PDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVR 889
+ L++G++ +L + HD+ G+ W L V ++ + + + F + WL K++ DG+
Sbjct: 742 -ETLNIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRL-- 798
Query: 890 DFACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKNRSKEFLMENSSRQRA 947
+ +++ + + YE+ I TG+ G T V++ + G K +++ + SSR +
Sbjct: 799 EVELYPSEVVEIQKLVHYEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFL--SSRSKV 856
Query: 948 FRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEM 998
F + + DTF+ ++ +G++ L +GH + F P +W V T+ + +
Sbjct: 857 FERASKDTFQLEAADVGEVYKLRLGHTG--EGFGP----SWFVDTVWLRHL 901
Score = 366 bits (939), Expect = e-101
Identities = 277/958 (28%), Positives = 458/958 (47%), Gaps = 113/958 (11%)
Query: 169 AKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQ 228
A +D+G + + + A + YE+ T DV AGTDAN+FI ++G + +
Sbjct: 27 ASEDDEGELEHEYYKARV----------YEVVTATGDVRGAGTDANVFITLFGENGL--S 74
Query: 229 QKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRL 288
K T+K K FE+ + F V +VG +I K+RI H+NTG+N W+ HV + +
Sbjct: 75 PKLQLTSK--SKSAFEKGNVDVFRVRTNNVG-LIYKVRIEHDNTGLNASWYLDHVIVTDM 131
Query: 289 LPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDI 348
K F C+ WL+ E D++ R+L+ F M G+
Sbjct: 132 ---KRPHLRYYFNCNNWLSKVEGDRQWCRDLLAS--FNPMDMPRGNK------------- 173
Query: 349 VLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAA 408
Y V+++TG++ GAGTDA V+I I+G+ GDTGER L EN + FE+G D FI++A
Sbjct: 174 --YEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRL---ENEKDNFEKGAEDRFILDAP 228
Query: 409 DLGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYE 468
DLG + KI + H+N A W++ ++ I + N+ ++ F RWL+L ++DG+++R
Sbjct: 229 DLGQLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQR---- 284
Query: 469 KEYTGDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHK 528
D+ + E I Y V+V TG +
Sbjct: 285 ---------------------------DILVGGA---------ETTAITYIVTVFTGDVR 308
Query: 529 DAATDSRAFIFLIG-EDDERSKRIWLDYPRGKRGFSRGSVEEFYVA-GLDVGIIKKIELG 586
A T S+ ++ + G ++ S +I+L+ F RG + F++ + + + ++ +G
Sbjct: 309 GAGTKSKIYLVMYGARGNKNSGKIFLE----GGVFDRGRTDIFHIELAVLLSPLSRVSVG 364
Query: 587 HDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVK 646
H W E++ + P G + C+ WL + + DG+ R + ++ K
Sbjct: 365 HGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEMVSLRKKRLKK 424
Query: 647 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIA 706
+ + VWT D+ GT+S IF+ +YG G T+E+ L+ F+ + F +E+ D+
Sbjct: 425 FPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIELPDLG 484
Query: 707 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVID 766
F K+R+ D S W LER+ L N D F WL + +V EM A
Sbjct: 485 RFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAEGP 544
Query: 767 E-EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSAN-WNKFERNNT 824
+M Y V V T ++ GAGTDANV++ +FG+ GD+G L N + FE+ N
Sbjct: 545 TVRRIMGMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNA 604
Query: 825 DTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDET--FHFQCDCWLSKSE 882
D F + +++ ++ ++R+ HD KG GW+L V V++ + E+ F C WL K +
Sbjct: 605 DEFTI-ESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDK 663
Query: 883 GDGQTVRDFACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKNRS--KEFL 938
DGQ VR+ +++ L+ Y I ++TG+ G T V++ L G K+ + + L
Sbjct: 664 DDGQLVRELLPSDSSAT--LKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLL 721
Query: 939 MENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEM 998
+ +++ + F +G D F +++ +G+I L +GH + +W + ++ I
Sbjct: 722 VSDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTG------MHASWFLGSVQIRVP 775
Query: 999 EYGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVP-VKYEVIVTTGYEPGA 1057
G Y F + + + +V E + S+V + V YEV + TG GA
Sbjct: 776 RQGKQYTFPANRWLDKNQADGRLEV-------ELYPSEVVEIQKLVHYEVEIWTGDVGGA 828
Query: 1058 GTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETL---ELVVTRLGLAAE 1112
GT A V++ I+G G T L + + +FER S D F LE E+ RLG E
Sbjct: 829 GTSARVYMQIYGEKGKTEVLFLSSRSK-VFERASKDTFQLEAADVGEVYKLRLGHTGE 885
Score = 347 bits (891), Expect = 3e-95
Identities = 255/871 (29%), Positives = 401/871 (46%), Gaps = 126/871 (14%)
Query: 5 ITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKST 64
+ YYF C WL+ E D Q R+LL NP+D +
Sbjct: 136 LRYYFNCNNWLSKVEGDRQWCRDLL-----------------ASFNPMD------MPRGN 172
Query: 65 TFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLD 124
+ V + TG AGTDA+VFI +FG DTG L++ K D FE+ + + F ++ D
Sbjct: 173 KYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEK---DNFEKGAEDRFILDAPD 229
Query: 125 LGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHA 184
LG L K+ +GH+N G + GWF+ + ++ + FP RWLA +EDDG I RD+
Sbjct: 230 LGQLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVG 289
Query: 185 ELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQF-- 242
+T T Y +T++T DV AGT + I++++YG NK K F
Sbjct: 290 GAETTAIT----YIVTVFTGDVRGAGTKSKIYLVMYGARG----------NKNSGKIFLE 335
Query: 243 ---FERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLT 299
F+R F +EL + + ++ +GH N G+N GW C V I L G + T
Sbjct: 336 GGVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFCEKVVI---LCPFTGIQQ-T 391
Query: 300 FPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSL-RQVYKEV---EEPLDIVLYSVQI 355
FPC WL D+KK DG + RQ+Y+ V ++ L +S+ +
Sbjct: 392 FPCSNWL----DEKKA----------------DGLIERQLYEMVSLRKKRLKKFPWSLWV 431
Query: 356 FTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNK-FERGTADTFIIEAADLGVIY 414
+T ++ AGT++ ++I IYG G T E L N NK F+ G + F IE DLG Y
Sbjct: 432 WTTDLKKAGTNSPIFIQIYGQKGRTDEILL----NPNNKWFKPGIIEKFRIELPDLGRFY 487
Query: 415 KIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGD 474
KI++ HD + W++E++ + N N+D++ F C RWL ++D + R
Sbjct: 488 KIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREM-------- 539
Query: 475 RSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDS 534
T GP + + Y+V+V TG+ + A TD+
Sbjct: 540 --------------------------TAEGPTVRRIMG--MARYHVTVCTGELEGAGTDA 571
Query: 535 RAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPES 594
++ L G+ + +R+ + F +G+ +EF + + + ++++ + HDG S
Sbjct: 572 NVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGS 631
Query: 595 CWLVEELCLAVPTQGTKYMLNCNC--WLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMT 652
W ++ + + Q + C WL KD+ DG V +LL + Y ++
Sbjct: 632 GWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDG--QLVRELLPSDSSATLKNFRYHIS 689
Query: 653 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQL----DKKKARFEREQNDTFIMEILDIAPF 708
+ TGDV G TDS +++ LYG T + L + K FER + D F +E L+I
Sbjct: 690 LKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLKDYFERGRVDEFTLETLNIGNI 749
Query: 709 TKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEE 768
++ I D G WFL + ++ G F WL + + L E+ +
Sbjct: 750 NRLVIGHDSTGMHASWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYP-SEVV 808
Query: 769 EMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFN 828
E+ + Y V + T D+ GAGT A V++ I+GE G + L L S+ FER + DTF
Sbjct: 809 EIQKLVHYEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFL--SSRSKVFERASKDTFQ 866
Query: 829 FPDMLSLGHLCKLRVWHDNKGIFPGWHLSYV 859
+ +G + KLR+ H +G P W + V
Sbjct: 867 L-EAADVGEVYKLRLGHTGEGFGPSWFVDTV 896
Score = 347 bits (891), Expect = 3e-95
Identities = 224/740 (30%), Positives = 359/740 (48%), Gaps = 103/740 (13%)
Query: 1 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQK 60
+ N+ Y FP RWLA++EDDG++ R++L GG + +
Sbjct: 259 IGNKRKYDFPLNRWLALDEDDGKIQRDILV--------------GGAETTAI-------- 296
Query: 61 DKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDD--TGMTLLKSSKTNSDKFERDSIEIF 118
T+ VT+ TG + AGT + +++ ++G + + +G L+ F+R +IF
Sbjct: 297 ----TYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGGV-----FDRGRTDIF 347
Query: 119 TVE-TLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSI 177
+E + L L +V +GH N G GWF + V + P G TFPC WL + + DG I
Sbjct: 348 HIELAVLLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLI 407
Query: 178 IRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKR 237
R L+ + P+ + ++T+D+ AGT++ IFI IYG T + L N +
Sbjct: 408 ERQLYEMVSLRKKRLKKFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGR-TDEILLNPNNK 466
Query: 238 EQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAET 297
+F+ +F +EL D+G KIR+ H+ GWH + + L +
Sbjct: 467 ----WFKPGIIEKFRIELPDLGRFY-KIRVWHDKRSSGSGWHLERMTLMNTL----NKDK 517
Query: 298 LTFPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFT 357
F C+RWL +EDD + +RE+ + ++R++ + + Y V + T
Sbjct: 518 YNFNCNRWLDANEDDNEIVREMTA---------EGPTVRRI-------MGMARYHVTVCT 561
Query: 358 GNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIK 417
G + GAGTDA VY+ ++GD+GDTGER L N T+ FE+G AD F IE+ + + +++
Sbjct: 562 GELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRNVRRVR 621
Query: 418 LRHDNSKWCADWYVEKVEIWND--TNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDR 475
+RHD + WY+++V + + D F C RWL K+DG+L R
Sbjct: 622 IRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVR----------- 670
Query: 476 SSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSR 535
E+ S A + Y++S+ TG A+TDSR
Sbjct: 671 -----------ELLPSDSSATL----------------KNFRYHISLKTGDVSGASTDSR 703
Query: 536 AFIFLIGEDDERSKRIWLDYPRG-KRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPES 594
+I L G+ + K++ L K F RG V+EF + L++G I ++ +GHD +
Sbjct: 704 VYIKLYGDKSDTIKQVLLVSDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHA 763
Query: 595 CWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVW 654
W + + + VP QG +Y N WL K++ DG +L + VV I V YE+ +W
Sbjct: 764 SWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLE--VELYPSEVVEIQKLVHYEVEIW 821
Query: 655 TGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIR 714
TGDV G GT + ++M +YG G TE + L + FER DTF +E D+ K+R+
Sbjct: 822 TGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSKVFERASKDTFQLEAADVGEVYKLRLG 881
Query: 715 IDGLGSRPEWFLERILLKNM 734
G G P WF++ + L+++
Sbjct: 882 HTGEGFGPSWFVDTVWLRHL 901
Score = 300 bits (768), Expect = 5e-81
Identities = 226/746 (30%), Positives = 350/746 (46%), Gaps = 119/746 (15%)
Query: 300 FPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGN 359
F RWLA ++D + + ELVP K G R Y+ VQ+ TGN
Sbjct: 992 FEAHRWLARGKEDNELVVELVPAG-------KPGPERNTYE------------VQVVTGN 1032
Query: 360 IPGAGTDAKVYITIYGD-LGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKL 418
+P AGTDA VY+TIYG+ GDTGER L KS+ ++NKFE+G DTF I A DLG + KI++
Sbjct: 1033 VPKAGTDANVYLTIYGEEYGDTGERPLKKSD-KSNKFEQGQTDTFTIYAIDLGALTKIRI 1091
Query: 419 RHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLER--LFYEKEYT---- 472
RHDN+ A W++++++I + NE + F C RWL+++++DG+L R L ++ Y
Sbjct: 1092 RHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQS 1151
Query: 473 -GDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAA 531
R ++P D +AL K D ST + V++ TG K+A
Sbjct: 1152 EEGRGGGDNNPLD--NLALEQK----DKSTT---------------FSVTIKTGVKKNAG 1190
Query: 532 TDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGAS 591
TD+ FI L G D+ + F R S+E F V LD+G + K+ LGHD
Sbjct: 1191 TDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTG 1250
Query: 592 PESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEM 651
W V+ + + P+ G C WLAK+ DG R + V YE+
Sbjct: 1251 KAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEI 1310
Query: 652 TVWTGDVVGGGTDSNIFMTLYGING-STEEMQL----DKKKARFEREQNDTFIMEILDIA 706
T++T DV GTD+NIF+ +YG + T++ L ++K FER+ FI+E+ D+
Sbjct: 1311 TLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVG 1370
Query: 707 P-FTKMRIRIDGLGSRPEWFLERI----LLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEM 761
K+RI + G P W + LL + + + F WL+ + K + E+
Sbjct: 1371 EIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIREL 1430
Query: 762 C-----------------AVIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGD 804
+ EE ++ Y+V + T +I GAGTDA V+I I+G+ GD
Sbjct: 1431 VPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNIPGAGTDAKVYITIYGDLGD 1490
Query: 805 SGTLALKQSAN-WNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKD 863
+G L +S N NKFER DTF + LG + K+++ HDN W++ V++ +
Sbjct: 1491 TGERYLGKSENRTNKFERGTADTF-IIEAADLGVIYKIKLRHDNSKWCADWYVEKVEIWN 1549
Query: 864 NSRDETFHFQCDCWLSKSEGDGQTVR---------------------------------D 890
++ ++ F F C WLS + DG+ R D
Sbjct: 1550 DTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCSSPADFWEIALSSKMADVD 1609
Query: 891 FACANNKICDELEE---TTYEIVIETGN----GGETRENVWLILEGRKNRSKEFLMENSS 943
+ + D ++E Y + + TG ++R ++LI E RSK ++
Sbjct: 1610 ISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFLIGED-DERSKRIWLDYPR 1668
Query: 944 RQRAFRKGTTDTFEFDSIYLGDIASL 969
+R F +G+ + F + +G I +
Sbjct: 1669 GKRGFSRGSVEEFYVAGLDVGIIKKI 1694
Score = 211 bits (536), Expect = 4e-54
Identities = 174/605 (28%), Positives = 277/605 (45%), Gaps = 76/605 (12%)
Query: 310 EDDKKTIRELVPYDIFTEKYMKDGSLRQVY---------KEVEEPLDIVLYSVQIFTGNI 360
EDD+++ R + Y + + GS+ + Y K++E VLY + ++TG++
Sbjct: 1654 EDDERSKRIWLDYPRGKRGFSR-GSVEEFYVAGLDVGIIKKIE-----VLYEMTVWTGDV 1707
Query: 361 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 420
G GTD+ +++T+YG G T E L K + R FER DTFI+E D+ K+++R
Sbjct: 1708 VGGGTDSNIFMTLYGINGSTEEMQLDKKKAR---FEREQNDTFIMEILDIAPFTKMRIRI 1764
Query: 421 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCS 480
D +W++E++ + N D +F G WLS +K G ++ C
Sbjct: 1765 DGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRK---------------GKKTLVCE 1809
Query: 481 SPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFL 540
A + D + Y V+V T A TD+ FI +
Sbjct: 1810 MCA----------------------VIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIII 1847
Query: 541 IGEDDERSKRIWLDYPRGKRGFSRGSVEEF-YVAGLDVGIIKKIELGHDGASPESCWLVE 599
GE+ + S + L F R + + F + L +G + K+ + HD W +
Sbjct: 1848 FGENGD-SGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLS 1906
Query: 600 ELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVWTGDVV 659
+ + ++ + C+CWL+K GDG T R F + + + + YE+ + TG+
Sbjct: 1907 YVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETGN-- 1964
Query: 660 GGGTDSNIFMTLYGINGSTEE--MQLDKKKARFEREQNDTFIMEILDIAPFTKMRI---- 713
GG T N+++ L G ++E M+ ++ F + DTF + + + + +
Sbjct: 1965 GGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLA 2024
Query: 714 RIDGLGSRPE--WFLERILLKNMNTGDLTMFYYGDWLS--QRKGKKTLVCEMCAVID--- 766
R D + E W ++ I + M G++ F+ D L +RK K V E+ +
Sbjct: 2025 REDRFIPKRELAWHVKTITITEMEYGNV-YFFNCDCLIPLKRKRKYFKVFEVTKTTESFA 2083
Query: 767 -EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTD 825
+ + + Y V V T GAGTDANVF+ IFG NGD+G LKQ N FER +TD
Sbjct: 2084 SKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMR-NLFERGSTD 2142
Query: 826 TFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDG 885
F F + L LG L K+R+ HD+ G GW + V+V + S F C WL K GDG
Sbjct: 2143 RF-FLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 2201
Query: 886 QTVRD 890
T RD
Sbjct: 2202 LTWRD 2206
Score = 197 bits (501), Expect = 5e-50
Identities = 136/410 (33%), Positives = 203/410 (49%), Gaps = 32/410 (7%)
Query: 58 EQKDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEI 117
E+ + T+++V +KT AGTDANVFI +FG D+G LK S N +KFER++ +
Sbjct: 1817 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQS-ANWNKFERNNTDT 1875
Query: 118 FTV-ETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGS 176
F + L LG L K+R+ HDN G PGW + +V+V S + F C WL+K+E DG
Sbjct: 1876 FNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQ 1935
Query: 177 IIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNK 236
+RD A + YEI + T + T N+++I+ G +++L N
Sbjct: 1936 TVRDFACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKN--RSKEFLMENS 1991
Query: 237 REQKQFFERKSASRFIVELEDVGEIIEKIRIGH--NNTGMNP----GWHCSHVDIRRLLP 290
Q+ F + + F + +G+I + +GH P WH + I +
Sbjct: 1992 SRQRAF-RKGTTDTFEFDSIYLGDIAS-LCVGHLAREDRFIPKRELAWHVKTITITEM-- 2047
Query: 291 DKDGAETLTFPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVL 350
+ F CD + K + +F + +V V V
Sbjct: 2048 --EYGNVYFFNCDCLIPLKRKRKY-------FKVFEVTKTTESFASKVQSLVP-----VK 2093
Query: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 410
Y V + TG PGAGTDA V++TI+G GDTG+R L + N FERG+ D F +E +L
Sbjct: 2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL--KQKMRNLFERGSTDRFFLETLEL 2151
Query: 411 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDG 460
G + K++L HD+S +C+ W VEKVE+ N + +F CGRWL K+ DG
Sbjct: 2152 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 2201
Score = 149 bits (375), Expect = 2e-35
Identities = 143/601 (23%), Positives = 256/601 (42%), Gaps = 69/601 (11%)
Query: 440 TNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCSSPADFWEIALSSKMADVDI 499
T+ F+FL G ++D R +R++ + G R + S +F+ +A +D+
Sbjct: 1643 TDSRAFIFLIG------EDDERSKRIWLDYP-RGKRGFSRGSVEEFY-------VAGLDV 1688
Query: 500 STVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGK 559
+ + + Y ++V TG TDS F+ L G + + + + K
Sbjct: 1689 GII---------KKIEVLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEE---MQLDKKK 1736
Query: 560 RGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCW 619
F R + F + LD+ K+ + DG W +E + L G M W
Sbjct: 1737 ARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDW 1796
Query: 620 LAKDRG-DGITSRVFDLLDAMVVNIGVKVLYEMTVWTGDVVGGGTDSNIFMTLYGINGST 678
L++ +G + + ++D + Y + V T D++G GTD+N+F+ ++G NG +
Sbjct: 1797 LSQRKGKKTLVCEMCAVIDEEEMMEWTS--YTVAVKTSDILGAGTDANVFIIIFGENGDS 1854
Query: 679 EEMQLDKKK--ARFEREQNDTF-IMEILDIAPFTKMRIRIDGLGSRPEWFLERILLKNMN 735
+ L + +FER DTF ++L + K+R+ D G P W L + +K+ +
Sbjct: 1855 GTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNS 1914
Query: 736 TGDLTMFYYGDWLSQRKGK----KTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTD 791
+ F WLS+ +G + C + DE +E T+Y + ++T + G T
Sbjct: 1915 RDETFHFQCDCWLSKSEGDGQTVRDFACANNKICDE---LEETTYEIVIETGN--GGETR 1969
Query: 792 ANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWH--DNKG 849
NV++I+ G S ++ S+ F + TDTF F D + LG + L V H
Sbjct: 1970 ENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEF-DSIYLGDIASLCVGHLAREDR 2028
Query: 850 IFP----GWHLSYVDVKDNSRDETFHFQCDCWLS--------KSEGDGQTVRDFACANNK 897
P WH+ + + + + F CDC + K +T FA +K
Sbjct: 2029 FIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFA---SK 2085
Query: 898 ICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDT 955
+ L YE+++ TG G T NV++ + G + + ++ R F +G+TD
Sbjct: 2086 V-QSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMR-NLFERGSTDR 2143
Query: 956 FEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLK 1015
F +++ LG++ + + H + W V+ + +T G FNC + K
Sbjct: 2144 FFLETLELGELRKVRLEHDS------SGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKK 2197
Query: 1016 R 1016
R
Sbjct: 2198 R 2198
Score = 111 bits (278), Expect = 3e-24
Identities = 59/117 (50%), Positives = 71/117 (60%), Gaps = 2/117 (1%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
+ V + TG + AGTDANVF+T+FG DTG LK N FER S + F +ETL+L
Sbjct: 2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNL--FERGSTDRFFLETLEL 2151
Query: 126 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLF 182
G+L KVRL HD++G GW V+ VEV S G F CGRWL K DG RDLF
Sbjct: 2152 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLF 2208
Score = 95.1 bits (235), Expect = 3e-19
Identities = 89/334 (26%), Positives = 147/334 (44%), Gaps = 60/334 (17%)
Query: 6 TYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKSTT 65
T++F C WL+ E DGQ R+ +N D L + TT
Sbjct: 1918 TFHFQCDCWLSKSEGDGQTVRDF----------------ACANNKICDEL------EETT 1955
Query: 66 FSVTIKTGVKKNAG-TDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLD 124
+ + I+TG N G T NV++ L G ++ + L+++S + F + + + F +++
Sbjct: 1956 YEIVIETG---NGGETRENVWLILEGRKNRSKEFLMENS-SRQRAFRKGTTDTFEFDSIY 2011
Query: 125 LGDLWKVRLGH----DN--TGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNED----- 173
LGD+ + +GH D + W V + + G F C +
Sbjct: 2012 LGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKYFK 2071
Query: 174 --DGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKY 231
+ + + F +++Q+ + V YE+ + T AGTDAN+F+ I+G +
Sbjct: 2072 VFEVTKTTESFASKVQSLVP---VKYEVIVTTGYEPGAGTDANVFVTIFGANG------- 2121
Query: 232 LCTNKREQKQ----FFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRR 287
T KRE KQ FER S RF +E ++GE + K+R+ H+++G GW V++
Sbjct: 2122 -DTGKRELKQKMRNLFERGSTDRFFLETLELGE-LRKVRLEHDSSGYCSGWLVEKVEVTN 2179
Query: 288 LLPDKDGAETLTFPCDRWLATSEDDKKTIRELVP 321
G T+ F C RWL D T R+L P
Sbjct: 2180 ---TSTGVATI-FNCGRWLDKKRGDGLTWRDLFP 2209
>gi|224458290 lipoxygenase homology domains 1 isoform 3 [Homo sapiens]
Length = 512
Score = 933 bits (2412), Expect = 0.0
Identities = 452/452 (100%), Positives = 452/452 (100%)
Query: 651 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTK 710
MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTK
Sbjct: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTK 60
Query: 711 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEM 770
MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEM
Sbjct: 61 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEM 120
Query: 771 MEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFP 830
MEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFP
Sbjct: 121 MEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFP 180
Query: 831 DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD 890
DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD
Sbjct: 181 DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD 240
Query: 891 FACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK 950
FACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK
Sbjct: 241 FACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK 300
Query: 951 GTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDC 1010
GTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDC
Sbjct: 301 GTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDC 360
Query: 1011 LIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGA 1070
LIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGA
Sbjct: 361 LIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGA 420
Query: 1071 NGDTGKRELKQKMRNLFERGSTDRFFLETLEL 1102
NGDTGKRELKQKMRNLFERGSTDRFFLETLEL
Sbjct: 421 NGDTGKRELKQKMRNLFERGSTDRFFLETLEL 452
Score = 216 bits (550), Expect = 1e-55
Identities = 161/571 (28%), Positives = 265/571 (46%), Gaps = 72/571 (12%)
Query: 68 VTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGD 127
+T+ TG GTD+N+F+TL+G T L K +FER+ + F +E LD+
Sbjct: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKA---RFEREQNDTFIMEILDIAP 57
Query: 128 LWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAELQ 187
K+R+ D G P WF++ + + + G F G WL++ + +++ ++ A +
Sbjct: 58 FTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMC-AVID 116
Query: 188 TRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKS 247
+ Y + + TSD+ AGTDAN+FIII+G + L + FER +
Sbjct: 117 EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENG---DSGTLALKQSANWNKFERNN 173
Query: 248 ASRF-IVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWL 306
F ++ +G + K+R+ H+N G+ PGWH S+VD++ D ET F CD WL
Sbjct: 174 TDTFNFPDMLSLGHLC-KLRVWHDNKGIFPGWHLSYVDVK----DNSRDETFHFQCDCWL 228
Query: 307 ATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNIPGAGTD 366
+ SE D +T+R+ + ++ E+EE Y + I TGN G T
Sbjct: 229 SKSEGDGQTVRDFACAN------------NKICDELEE----TTYEIVIETGN--GGETR 270
Query: 367 AKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH----DN 422
V++ + G + E +L ++ +R F +GT DTF ++ LG I + + H D
Sbjct: 271 ENVWLILEGRKNRSKE-FLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDR 329
Query: 423 --SKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCS 480
K W+V+ + I + + F C + LK+ +R +++
Sbjct: 330 FIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKR-----KRKYFKV----------- 373
Query: 481 SPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFL 540
+++ T A VQ + Y V VTTG A TD+ F+ +
Sbjct: 374 ----------------FEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTI 417
Query: 541 IGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPESCWLVEE 600
G + + KR R F RGS + F++ L++G ++K+ L HD + S WLVE+
Sbjct: 418 FGANGDTGKRELKQKMRNL--FERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEK 475
Query: 601 LCLAVPTQGTKYMLNCNCWLAKDRGDGITSR 631
+ + + G + NC WL K RGDG+T R
Sbjct: 476 VEVTNTSTGVATIFNCGRWLDKKRGDGLTWR 506
Score = 203 bits (517), Expect = 6e-52
Identities = 161/551 (29%), Positives = 253/551 (45%), Gaps = 61/551 (11%)
Query: 355 IFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIY 414
++TG++ G GTD+ +++T+YG G T E L K + R FER DTFI+E D+
Sbjct: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKAR---FEREQNDTFIMEILDIAPFT 59
Query: 415 KIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGD 474
K+++R D +W++E++ + N D +F G WLS +K G
Sbjct: 60 KMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRK---------------GK 104
Query: 475 RSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDS 534
++ C A + D + Y V+V T A TD+
Sbjct: 105 KTLVCEMCA----------------------VIDEEEMMEWTSYTVAVKTSDILGAGTDA 142
Query: 535 RAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEF-YVAGLDVGIIKKIELGHDGASPE 593
FI + GE+ + S + L F R + + F + L +G + K+ + HD
Sbjct: 143 NVFIIIFGENGD-SGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIF 201
Query: 594 SCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTV 653
W + + + ++ + C+CWL+K GDG T R F + + + + YE+ +
Sbjct: 202 PGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVI 261
Query: 654 WTGDVVGGGTDSNIFMTLYGINGSTEE--MQLDKKKARFEREQNDTFIMEILDIAPFTKM 711
TG+ GG T N+++ L G ++E M+ ++ F + DTF + + + +
Sbjct: 262 ETGN--GGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASL 319
Query: 712 RI----RIDGLGSRPE--WFLERILLKNMNTGDLTMFYYGDWLS--QRKGKKTLVCEMCA 763
+ R D + E W ++ I + M G++ F+ D L +RK K V E+
Sbjct: 320 CVGHLAREDRFIPKRELAWHVKTITITEMEYGNV-YFFNCDCLIPLKRKRKYFKVFEVTK 378
Query: 764 VID----EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKF 819
+ + + + Y V V T GAGTDANVF+ IFG NGD+G LKQ N F
Sbjct: 379 TTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMR-NLF 437
Query: 820 ERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLS 879
ER +TD F F + L LG L K+R+ HD+ G GW + V+V + S F C WL
Sbjct: 438 ERGSTDRF-FLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLD 496
Query: 880 KSEGDGQTVRD 890
K GDG T RD
Sbjct: 497 KKRGDGLTWRD 507
Score = 197 bits (501), Expect = 5e-50
Identities = 136/410 (33%), Positives = 203/410 (49%), Gaps = 32/410 (7%)
Query: 58 EQKDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEI 117
E+ + T+++V +KT AGTDANVFI +FG D+G LK S N +KFER++ +
Sbjct: 118 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQS-ANWNKFERNNTDT 176
Query: 118 FTV-ETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGS 176
F + L LG L K+R+ HDN G PGW + +V+V S + F C WL+K+E DG
Sbjct: 177 FNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQ 236
Query: 177 IIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNK 236
+RD A + YEI + T + T N+++I+ G +++L N
Sbjct: 237 TVRDFACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKN--RSKEFLMENS 292
Query: 237 REQKQFFERKSASRFIVELEDVGEIIEKIRIGH--NNTGMNP----GWHCSHVDIRRLLP 290
Q+ F + + F + +G+I + +GH P WH + I +
Sbjct: 293 SRQRAF-RKGTTDTFEFDSIYLGDIAS-LCVGHLAREDRFIPKRELAWHVKTITITEM-- 348
Query: 291 DKDGAETLTFPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVL 350
+ F CD + K + +F + +V V V
Sbjct: 349 --EYGNVYFFNCDCLIPLKRKRKY-------FKVFEVTKTTESFASKVQSLVP-----VK 394
Query: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 410
Y V + TG PGAGTDA V++TI+G GDTG+R L + N FERG+ D F +E +L
Sbjct: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL--KQKMRNLFERGSTDRFFLETLEL 452
Query: 411 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDG 460
G + K++L HD+S +C+ W VEKVE+ N + +F CGRWL K+ DG
Sbjct: 453 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 502
Score = 146 bits (369), Expect = 9e-35
Identities = 128/521 (24%), Positives = 224/521 (42%), Gaps = 46/521 (8%)
Query: 520 VSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGI 579
++V TG TDS F+ L G + + + + K F R + F + LD+
Sbjct: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEE---MQLDKKKARFEREQNDTFIMEILDIAP 57
Query: 580 IKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRG-DGITSRVFDLLDA 638
K+ + DG W +E + L G M WL++ +G + + ++D
Sbjct: 58 FTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDE 117
Query: 639 MVVNIGVKVLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKK--ARFEREQND 696
+ Y + V T D++G GTD+N+F+ ++G NG + + L + +FER D
Sbjct: 118 EEMMEWTS--YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTD 175
Query: 697 TF-IMEILDIAPFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGK- 754
TF ++L + K+R+ D G P W L + +K+ + + F WLS+ +G
Sbjct: 176 TFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDG 235
Query: 755 ---KTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALK 811
+ C + DE +E T+Y + ++T + G T NV++I+ G S ++
Sbjct: 236 QTVRDFACANNKICDE---LEETTYEIVIETGN--GGETRENVWLILEGRKNRSKEFLME 290
Query: 812 QSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWH--DNKGIFP----GWHLSYVDVKDNS 865
S+ F + TDTF F D + LG + L V H P WH+ + + +
Sbjct: 291 NSSRQRAFRKGTTDTFEF-DSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEME 349
Query: 866 RDETFHFQCDCWLS--------KSEGDGQTVRDFACANNKICDELEETTYEIVIETG--N 915
+ F CDC + K +T FA +K+ L YE+++ TG
Sbjct: 350 YGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFA---SKV-QSLVPVKYEVIVTTGYEP 405
Query: 916 GGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLA 975
G T NV++ + G + + ++ R F +G+TD F +++ LG++ + + H +
Sbjct: 406 GAGTDANVFVTIFGANGDTGKRELKQKMR-NLFERGSTDRFFLETLELGELRKVRLEHDS 464
Query: 976 REDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKR 1016
W V+ + +T G FNC + KR
Sbjct: 465 ------SGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKR 499
Score = 111 bits (278), Expect = 3e-24
Identities = 59/117 (50%), Positives = 71/117 (60%), Gaps = 2/117 (1%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
+ V + TG + AGTDANVF+T+FG DTG LK N FER S + F +ETL+L
Sbjct: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNL--FERGSTDRFFLETLEL 452
Query: 126 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLF 182
G+L KVRL HD++G GW V+ VEV S G F CGRWL K DG RDLF
Sbjct: 453 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLF 509
Score = 95.1 bits (235), Expect = 3e-19
Identities = 89/334 (26%), Positives = 147/334 (44%), Gaps = 60/334 (17%)
Query: 6 TYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKSTT 65
T++F C WL+ E DGQ R+ +N D L + TT
Sbjct: 219 TFHFQCDCWLSKSEGDGQTVRDF----------------ACANNKICDEL------EETT 256
Query: 66 FSVTIKTGVKKNAG-TDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLD 124
+ + I+TG N G T NV++ L G ++ + L+++S + F + + + F +++
Sbjct: 257 YEIVIETG---NGGETRENVWLILEGRKNRSKEFLMENS-SRQRAFRKGTTDTFEFDSIY 312
Query: 125 LGDLWKVRLGH----DN--TGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNED----- 173
LGD+ + +GH D + W V + + G F C +
Sbjct: 313 LGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKYFK 372
Query: 174 --DGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKY 231
+ + + F +++Q+ + V YE+ + T AGTDAN+F+ I+G +
Sbjct: 373 VFEVTKTTESFASKVQSLVP---VKYEVIVTTGYEPGAGTDANVFVTIFGANG------- 422
Query: 232 LCTNKREQKQ----FFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRR 287
T KRE KQ FER S RF +E ++GE + K+R+ H+++G GW V++
Sbjct: 423 -DTGKRELKQKMRNLFERGSTDRFFLETLELGE-LRKVRLEHDSSGYCSGWLVEKVEVTN 480
Query: 288 LLPDKDGAETLTFPCDRWLATSEDDKKTIRELVP 321
G T+ F C RWL D T R+L P
Sbjct: 481 ---TSTGVATI-FNCGRWLDKKRGDGLTWRDLFP 510
>gi|239754889 PREDICTED: similar to hCG2036697 [Homo sapiens]
Length = 1029
Score = 108 bits (269), Expect = 4e-23
Identities = 66/183 (36%), Positives = 94/183 (51%), Gaps = 26/183 (14%)
Query: 1 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESY-VLPQSEEGRGGGDNNPLDNLALEQ 59
MN+ +Y P QRWLA +++DG++ RE + + VLP
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLP--------------------- 39
Query: 60 KDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFT 119
T + V + TG NAGT ANV+I++ G + DTG L SK +S F R + F
Sbjct: 40 ---VTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSK-SSFNFLRGQTDTFF 95
Query: 120 VETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIR 179
+E + LGDL K+ +GHD G GWF+D V + P+ F C RWL + EDD I+R
Sbjct: 96 LEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVR 155
Query: 180 DLF 182
+L+
Sbjct: 156 ELY 158
Score = 99.0 bits (245), Expect = 2e-20
Identities = 57/170 (33%), Positives = 87/170 (51%), Gaps = 18/170 (10%)
Query: 301 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 360
P RWLA ++D + RE + + + L + +Y V + TG +
Sbjct: 10 PVQRWLARDQEDGEICREF-----------------PLLSKGQPVLPVTIYEVNVATGEL 52
Query: 361 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 420
AGT A VYI+I+G+ GDTG R L +S++ N F RG DTF +EA LG + KI + H
Sbjct: 53 WNAGTVANVYISIHGEKGDTGSRQLFRSKSSFN-FLRGQTDTFFLEAVHLGDLCKIVIGH 111
Query: 421 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 470
D W+++ V I + T E+ F C RWL ++D ++ R Y ++
Sbjct: 112 DGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
Score = 92.8 bits (229), Expect = 2e-18
Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 1/165 (0%)
Query: 734 MNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDAN 793
MN+G WL++ + + E + + ++ T Y V V T ++ AGT AN
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
Query: 794 VFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPG 853
V+I I GE GD+G+ L +S + F R TDTF F + + LG LCK+ + HD G G
Sbjct: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTF-FLEAVHLGDLCKIVIGHDGLGPGNG 119
Query: 854 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKI 898
W L V +KD + + + F C WL + E D + VR+ +N I
Sbjct: 120 WFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSI 164
Score = 84.3 bits (207), Expect = 6e-16
Identities = 51/157 (32%), Positives = 83/157 (52%), Gaps = 3/157 (1%)
Query: 609 GTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVWTGDVVGGGTDSNIF 668
G ++ + WLA+D+ DG R F LL + V + YE+ V TG++ GT +N++
Sbjct: 4 GKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTI-YEVNVATGELWNAGTVANVY 62
Query: 669 MTLYGINGSTEEMQLDKKKARFE--REQNDTFIMEILDIAPFTKMRIRIDGLGSRPEWFL 726
++++G G T QL + K+ F R Q DTF +E + + K+ I DGLG WFL
Sbjct: 63 ISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFL 122
Query: 727 ERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCA 763
+ +++K+ T F+ WL Q + +V E+ A
Sbjct: 123 DDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYA 159
Score = 77.4 bits (189), Expect = 7e-14
Identities = 56/167 (33%), Positives = 81/167 (48%), Gaps = 9/167 (5%)
Query: 157 GKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIF 216
GK P RWLA++++DG I R+ F + + P YE+ + T +++ AGT AN++
Sbjct: 4 GKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVY 62
Query: 217 IIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNP 276
I I+G + T + L +K F R F +E +G++ KI IGH+ G
Sbjct: 63 ISIHG-EKGDTGSRQLFRSKSSFN--FLRGQTDTFFLEAVHLGDLC-KIVIGHDGLGPGN 118
Query: 277 GWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYD 323
GW V I+ D F C RWL EDD K +REL D
Sbjct: 119 GWFLDDVVIK----DPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
Score = 68.9 bits (167), Expect = 2e-11
Identities = 36/99 (36%), Positives = 56/99 (56%), Gaps = 1/99 (1%)
Query: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 410
Y V ++TG + A T+++V++ ++G+ GD+G R L KS N KF+RG D F + A L
Sbjct: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKS-NMQVKFQRGQIDKFQVAAVSL 694
Query: 411 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLC 449
G + K+ LR + S WY E+V + E +F C
Sbjct: 695 GKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 63.5 bits (153), Expect = 1e-09
Identities = 33/113 (29%), Positives = 58/113 (51%), Gaps = 1/113 (0%)
Query: 514 PIIPYYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVA 573
P+ Y V+V TG+ +A T + +I + GE + R L + F RG + F++
Sbjct: 39 PVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSR-QLFRSKSSFNFLRGQTDTFFLE 97
Query: 574 GLDVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGD 626
+ +G + KI +GHDG P + W ++++ + PT +Y C+ WL + D
Sbjct: 98 AVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDD 150
Score = 59.3 bits (142), Expect = 2e-08
Identities = 106/478 (22%), Positives = 173/478 (36%), Gaps = 126/478 (26%)
Query: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 410
+ V + TGN GT A V + +YGD G TG L K + F G D F
Sbjct: 540 WKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSE-QLFLPGHEDEF------- 588
Query: 411 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 470
++ ++H SK D F WLS + DG +
Sbjct: 589 ----QVTMQHMKSKKILD------------------FAANVWLSRIQADGDVV------- 619
Query: 471 YTGDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDA 530
C P V G A + + Y V V TG+ K A
Sbjct: 620 --------CELPV------------------VKGGQAIFP-----LRYQVDVYTGQLKHA 648
Query: 531 ATDSRAFIFLIGE-DDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDG 589
T+S F+ L GE D ++++ + K F RG +++F VA + +G ++K+ L +
Sbjct: 649 ETESEVFLCLFGERGDSGLRQLYKSNMQVK--FQRGQIDKFQVAAVSLGKLQKVLLRCEA 706
Query: 590 ASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLY 649
+ W E++ + P ++ + C + + F +M+
Sbjct: 707 SDKSQYWYCEQVIVREPGTTSESIFTC---------QSLPAHNFQASPSMLYR------- 750
Query: 650 EMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFT 709
+ TV T ++ G + +G GS L +KKA + I+ + + F
Sbjct: 751 DETVPTSLILKGAEEYGTRNRTWGTAGSF----LLQKKAILK-----PLIVTSVSQSLFC 801
Query: 710 KMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEE 769
+++ G+ W + +LK + T +W V+ E
Sbjct: 802 AYEVKVSVHGA---W---KAVLKRKESHGFTQEL--EW---------------TVLAGEL 838
Query: 770 MMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTF 827
+W V + T D+ AGT A VF+ ++GE SG + L S F N D F
Sbjct: 839 DGDW---KVTIVTGDLENAGTTATVFLYVYGETKCSGPIIL-GSGKHQLFNPNTADIF 892
Score = 58.9 bits (141), Expect = 3e-08
Identities = 36/70 (51%), Positives = 44/70 (62%), Gaps = 2/70 (2%)
Query: 1035 SKVQSLVPVK-YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGST 1092
SK Q ++PV YEV V TG AGT ANV+++I G GDTG R+L + K F RG T
Sbjct: 32 SKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQT 91
Query: 1093 DRFFLETLEL 1102
D FFLE + L
Sbjct: 92 DTFFLEAVHL 101
Score = 58.2 bits (139), Expect = 4e-08
Identities = 56/228 (24%), Positives = 93/228 (40%), Gaps = 36/228 (15%)
Query: 649 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL--DKKKARFEREQNDTFIMEILDIA 706
+++ V TG+ GT +N+ + +YG G T + L D + F D F
Sbjct: 540 WKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF-------- 588
Query: 707 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVID 766
++ +++M + + F WLS+ + +VCE+ V
Sbjct: 589 ---------------------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVKG 627
Query: 767 EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDT 826
+ + Y V V T + A T++ VF+ +FGE GDSG L +S KF+R D
Sbjct: 628 GQAIFP-LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDK 686
Query: 827 FNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQC 874
F +SLG L K+ + + W+ V V++ F C
Sbjct: 687 FQVA-AVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 56.6 bits (135), Expect = 1e-07
Identities = 36/106 (33%), Positives = 53/106 (50%), Gaps = 1/106 (0%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
+ V + TG K+A T++ VF+ LFG + D+G+ L S KF+R I+ F V + L
Sbjct: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQV-KFQRGQIDKFQVAAVSL 694
Query: 126 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKN 171
G L KV L + + K+ W+ + V V P F C A N
Sbjct: 695 GKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTCQSLPAHN 740
Score = 55.8 bits (133), Expect = 2e-07
Identities = 40/142 (28%), Positives = 65/142 (45%), Gaps = 11/142 (7%)
Query: 870 FHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETG---NGGETRENVWLI 926
F+ WL++ + DG+ R+F + K L T YE+ + TG N G T NV++
Sbjct: 7 FYVPVQRWLARDQEDGEICREFPLLS-KGQPVLPVTIYEVNVATGELWNAG-TVANVYIS 64
Query: 927 LEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKREL 986
+ G K + + S F +G TDTF ++++LGD+ + +GH D P
Sbjct: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGH----DGLGPGN-- 118
Query: 987 AWHVKTITITEMEYGNVYFFNC 1008
W + + I + Y F C
Sbjct: 119 GWFLDDVVIKDPTTNYEYAFFC 140
Score = 51.6 bits (122), Expect = 4e-06
Identities = 26/66 (39%), Positives = 42/66 (63%), Gaps = 1/66 (1%)
Query: 1038 QSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGSTDRFF 1096
Q++ P++Y+V V TG A T++ VF+ +FG GD+G R+L K M+ F+RG D+F
Sbjct: 629 QAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQ 688
Query: 1097 LETLEL 1102
+ + L
Sbjct: 689 VAAVSL 694
Score = 49.3 bits (116), Expect = 2e-05
Identities = 49/246 (19%), Positives = 98/246 (39%), Gaps = 43/246 (17%)
Query: 768 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTF 827
E ++ + V V T + GT ANV + ++G+ G +G ++L++ ++ F + D F
Sbjct: 532 ETLLSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF 588
Query: 828 NFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQT 887
+++ H+ ++ F + WLS+ + DG
Sbjct: 589 Q----VTMQHMKSKKI--------------------------LDFAANVWLSRIQADGDV 618
Query: 888 VRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQ 945
V + K + Y++ + TG ET V+L L G + S + S+ Q
Sbjct: 619 VCELPVV--KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQ 676
Query: 946 RAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYF 1005
F++G D F+ ++ LG + + + A + + W+ + + + E +
Sbjct: 677 VKFQRGQIDKFQVAAVSLGKLQKVLLRCEASD------KSQYWYCEQVIVREPGTTSESI 730
Query: 1006 FNCDCL 1011
F C L
Sbjct: 731 FTCQSL 736
Score = 40.8 bits (94), Expect = 0.007
Identities = 44/221 (19%), Positives = 95/221 (42%), Gaps = 39/221 (17%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
+ V + TG N GT ANV + ++G + TG L+ +DS E +
Sbjct: 540 WKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLR----------KDSSEQLFLP---- 582
Query: 126 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAE 185
GH++ + V + K + F WL++ + DG ++ +L +
Sbjct: 583 --------GHEDEFQ--------VTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVK 626
Query: 186 LQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFER 245
++ + Y++ +YT + A T++ +F+ ++G ++ +N + + F+R
Sbjct: 627 GGQAIFP--LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVK---FQR 681
Query: 246 KSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIR 286
+F V +G+ ++K+ + + + W+C V +R
Sbjct: 682 GQIDKFQVAAVSLGK-LQKVLLRCEASDKSQYWYCEQVIVR 721
Score = 33.5 bits (75), Expect = 1.2
Identities = 20/53 (37%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIF 118
+ VTI TG +NAGT A VF+ ++G +G +L S K F ++ +IF
Sbjct: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGK--HQLFNPNTADIF 892
Score = 32.7 bits (73), Expect = 2.0
Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 4/69 (5%)
Query: 1028 KTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNL 1086
K F S L +++V+V TG GT ANV + ++G G TG L K L
Sbjct: 523 KEIRHFQSSETLLSEDEWKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLRKDSSEQL 579
Query: 1087 FERGSTDRF 1095
F G D F
Sbjct: 580 FLPGHEDEF 588
>gi|239749428 PREDICTED: hypothetical protein XP_002347033 [Homo
sapiens]
Length = 1029
Score = 108 bits (269), Expect = 4e-23
Identities = 66/183 (36%), Positives = 94/183 (51%), Gaps = 26/183 (14%)
Query: 1 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESY-VLPQSEEGRGGGDNNPLDNLALEQ 59
MN+ +Y P QRWLA +++DG++ RE + + VLP
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLP--------------------- 39
Query: 60 KDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFT 119
T + V + TG NAGT ANV+I++ G + DTG L SK +S F R + F
Sbjct: 40 ---VTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSK-SSFNFLRGQTDTFF 95
Query: 120 VETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIR 179
+E + LGDL K+ +GHD G GWF+D V + P+ F C RWL + EDD I+R
Sbjct: 96 LEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVR 155
Query: 180 DLF 182
+L+
Sbjct: 156 ELY 158
Score = 99.0 bits (245), Expect = 2e-20
Identities = 57/170 (33%), Positives = 87/170 (51%), Gaps = 18/170 (10%)
Query: 301 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 360
P RWLA ++D + RE + + + L + +Y V + TG +
Sbjct: 10 PVQRWLARDQEDGEICREF-----------------PLLSKGQPVLPVTIYEVNVATGEL 52
Query: 361 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 420
AGT A VYI+I+G+ GDTG R L +S++ N F RG DTF +EA LG + KI + H
Sbjct: 53 WNAGTVANVYISIHGEKGDTGSRQLFRSKSSFN-FLRGQTDTFFLEAVHLGDLCKIVIGH 111
Query: 421 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 470
D W+++ V I + T E+ F C RWL ++D ++ R Y ++
Sbjct: 112 DGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
Score = 92.8 bits (229), Expect = 2e-18
Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 1/165 (0%)
Query: 734 MNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDAN 793
MN+G WL++ + + E + + ++ T Y V V T ++ AGT AN
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
Query: 794 VFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPG 853
V+I I GE GD+G+ L +S + F R TDTF F + + LG LCK+ + HD G G
Sbjct: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTF-FLEAVHLGDLCKIVIGHDGLGPGNG 119
Query: 854 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKI 898
W L V +KD + + + F C WL + E D + VR+ +N I
Sbjct: 120 WFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSI 164
Score = 84.3 bits (207), Expect = 6e-16
Identities = 51/157 (32%), Positives = 83/157 (52%), Gaps = 3/157 (1%)
Query: 609 GTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVWTGDVVGGGTDSNIF 668
G ++ + WLA+D+ DG R F LL + V + YE+ V TG++ GT +N++
Sbjct: 4 GKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTI-YEVNVATGELWNAGTVANVY 62
Query: 669 MTLYGINGSTEEMQLDKKKARFE--REQNDTFIMEILDIAPFTKMRIRIDGLGSRPEWFL 726
++++G G T QL + K+ F R Q DTF +E + + K+ I DGLG WFL
Sbjct: 63 ISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFL 122
Query: 727 ERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCA 763
+ +++K+ T F+ WL Q + +V E+ A
Sbjct: 123 DDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYA 159
Score = 77.4 bits (189), Expect = 7e-14
Identities = 56/167 (33%), Positives = 81/167 (48%), Gaps = 9/167 (5%)
Query: 157 GKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIF 216
GK P RWLA++++DG I R+ F + + P YE+ + T +++ AGT AN++
Sbjct: 4 GKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVY 62
Query: 217 IIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNP 276
I I+G + T + L +K F R F +E +G++ KI IGH+ G
Sbjct: 63 ISIHG-EKGDTGSRQLFRSKSSFN--FLRGQTDTFFLEAVHLGDLC-KIVIGHDGLGPGN 118
Query: 277 GWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYD 323
GW V I+ D F C RWL EDD K +REL D
Sbjct: 119 GWFLDDVVIK----DPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
Score = 68.9 bits (167), Expect = 2e-11
Identities = 36/99 (36%), Positives = 56/99 (56%), Gaps = 1/99 (1%)
Query: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 410
Y V ++TG + A T+++V++ ++G+ GD+G R L KS N KF+RG D F + A L
Sbjct: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKS-NMQVKFQRGQIDKFQVAAVSL 694
Query: 411 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLC 449
G + K+ LR + S WY E+V + E +F C
Sbjct: 695 GKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 63.5 bits (153), Expect = 1e-09
Identities = 33/113 (29%), Positives = 58/113 (51%), Gaps = 1/113 (0%)
Query: 514 PIIPYYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVA 573
P+ Y V+V TG+ +A T + +I + GE + R L + F RG + F++
Sbjct: 39 PVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSR-QLFRSKSSFNFLRGQTDTFFLE 97
Query: 574 GLDVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGD 626
+ +G + KI +GHDG P + W ++++ + PT +Y C+ WL + D
Sbjct: 98 AVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDD 150
Score = 62.8 bits (151), Expect = 2e-09
Identities = 105/486 (21%), Positives = 172/486 (35%), Gaps = 142/486 (29%)
Query: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 410
+ V + TGN GT A V + +YGD G TG L K + F G D F
Sbjct: 540 WKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSE-QLFLPGHEDEF------- 588
Query: 411 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 470
++ ++H SK D F WLS + DG +
Sbjct: 589 ----QVTMQHMKSKKILD------------------FAANVWLSRIQADGDVV------- 619
Query: 471 YTGDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDA 530
C P V G A + + Y V V TG+ K A
Sbjct: 620 --------CELPV------------------VKGGQAIFP-----LRYQVDVYTGQLKHA 648
Query: 531 ATDSRAFIFLIGE-DDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDG 589
T+S F+ L GE D ++++ + K F RG +++F VA + +G ++K+ L +
Sbjct: 649 ETESEVFLCLFGERGDSGLRQLYKSNMQVK--FQRGQIDKFQVAAVSLGKLQKVLLRCEA 706
Query: 590 ASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLY 649
+ W E++ + P ++ + C + + F +M+
Sbjct: 707 SDKSQYWYCEQVIVREPGTTSESIFTC---------QSLPAHNFQASPSMLYR------- 750
Query: 650 EMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFT 709
+ TV T ++ G + +G GS L +KKA + I+ + + F
Sbjct: 751 DETVPTSLILKGAEEYGTRNRTWGTAGSF----LLQKKAILK-----PLIVTSVSQSLFC 801
Query: 710 KMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEE 769
+++ +G W + K K++ C +
Sbjct: 802 AYEVKVS--------------------------VHGAWKAVLKRKESHGC--------TQ 827
Query: 770 MMEWT--------SYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFER 821
+EWT + V + T D+ AGT A VF+ ++GE SG + L S F
Sbjct: 828 ELEWTVLAGELDGDWKVTIVTGDLENAGTTATVFLYVYGETKCSGPIIL-GSGKHQLFNP 886
Query: 822 NNTDTF 827
N D F
Sbjct: 887 NTADIF 892
Score = 58.9 bits (141), Expect = 3e-08
Identities = 36/70 (51%), Positives = 44/70 (62%), Gaps = 2/70 (2%)
Query: 1035 SKVQSLVPVK-YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGST 1092
SK Q ++PV YEV V TG AGT ANV+++I G GDTG R+L + K F RG T
Sbjct: 32 SKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQT 91
Query: 1093 DRFFLETLEL 1102
D FFLE + L
Sbjct: 92 DTFFLEAVHL 101
Score = 58.2 bits (139), Expect = 4e-08
Identities = 56/228 (24%), Positives = 93/228 (40%), Gaps = 36/228 (15%)
Query: 649 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL--DKKKARFEREQNDTFIMEILDIA 706
+++ V TG+ GT +N+ + +YG G T + L D + F D F
Sbjct: 540 WKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF-------- 588
Query: 707 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVID 766
++ +++M + + F WLS+ + +VCE+ V
Sbjct: 589 ---------------------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVKG 627
Query: 767 EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDT 826
+ + Y V V T + A T++ VF+ +FGE GDSG L +S KF+R D
Sbjct: 628 GQAIFP-LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDK 686
Query: 827 FNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQC 874
F +SLG L K+ + + W+ V V++ F C
Sbjct: 687 FQVA-AVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 56.6 bits (135), Expect = 1e-07
Identities = 36/106 (33%), Positives = 53/106 (50%), Gaps = 1/106 (0%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
+ V + TG K+A T++ VF+ LFG + D+G+ L S KF+R I+ F V + L
Sbjct: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQV-KFQRGQIDKFQVAAVSL 694
Query: 126 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKN 171
G L KV L + + K+ W+ + V V P F C A N
Sbjct: 695 GKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTCQSLPAHN 740
Score = 55.8 bits (133), Expect = 2e-07
Identities = 40/142 (28%), Positives = 65/142 (45%), Gaps = 11/142 (7%)
Query: 870 FHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETG---NGGETRENVWLI 926
F+ WL++ + DG+ R+F + K L T YE+ + TG N G T NV++
Sbjct: 7 FYVPVQRWLARDQEDGEICREFPLLS-KGQPVLPVTIYEVNVATGELWNAG-TVANVYIS 64
Query: 927 LEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKREL 986
+ G K + + S F +G TDTF ++++LGD+ + +GH D P
Sbjct: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGH----DGLGPGN-- 118
Query: 987 AWHVKTITITEMEYGNVYFFNC 1008
W + + I + Y F C
Sbjct: 119 GWFLDDVVIKDPTTNYEYAFFC 140
Score = 51.6 bits (122), Expect = 4e-06
Identities = 26/66 (39%), Positives = 42/66 (63%), Gaps = 1/66 (1%)
Query: 1038 QSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGSTDRFF 1096
Q++ P++Y+V V TG A T++ VF+ +FG GD+G R+L K M+ F+RG D+F
Sbjct: 629 QAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQ 688
Query: 1097 LETLEL 1102
+ + L
Sbjct: 689 VAAVSL 694
Score = 49.3 bits (116), Expect = 2e-05
Identities = 49/246 (19%), Positives = 98/246 (39%), Gaps = 43/246 (17%)
Query: 768 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTF 827
E ++ + V V T + GT ANV + ++G+ G +G ++L++ ++ F + D F
Sbjct: 532 ETLLSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF 588
Query: 828 NFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQT 887
+++ H+ ++ F + WLS+ + DG
Sbjct: 589 Q----VTMQHMKSKKI--------------------------LDFAANVWLSRIQADGDV 618
Query: 888 VRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQ 945
V + K + Y++ + TG ET V+L L G + S + S+ Q
Sbjct: 619 VCELPVV--KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQ 676
Query: 946 RAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYF 1005
F++G D F+ ++ LG + + + A + + W+ + + + E +
Sbjct: 677 VKFQRGQIDKFQVAAVSLGKLQKVLLRCEASD------KSQYWYCEQVIVREPGTTSESI 730
Query: 1006 FNCDCL 1011
F C L
Sbjct: 731 FTCQSL 736
Score = 40.8 bits (94), Expect = 0.007
Identities = 44/221 (19%), Positives = 95/221 (42%), Gaps = 39/221 (17%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
+ V + TG N GT ANV + ++G + TG L+ +DS E +
Sbjct: 540 WKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLR----------KDSSEQLFLP---- 582
Query: 126 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAE 185
GH++ + V + K + F WL++ + DG ++ +L +
Sbjct: 583 --------GHEDEFQ--------VTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVK 626
Query: 186 LQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFER 245
++ + Y++ +YT + A T++ +F+ ++G ++ +N + + F+R
Sbjct: 627 GGQAIFP--LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVK---FQR 681
Query: 246 KSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIR 286
+F V +G+ ++K+ + + + W+C V +R
Sbjct: 682 GQIDKFQVAAVSLGK-LQKVLLRCEASDKSQYWYCEQVIVR 721
Score = 33.5 bits (75), Expect = 1.2
Identities = 20/53 (37%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIF 118
+ VTI TG +NAGT A VF+ ++G +G +L S K F ++ +IF
Sbjct: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGK--HQLFNPNTADIF 892
Score = 32.7 bits (73), Expect = 2.0
Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 4/69 (5%)
Query: 1028 KTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNL 1086
K F S L +++V+V TG GT ANV + ++G G TG L K L
Sbjct: 523 KEIRHFQSSETLLSEDEWKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLRKDSSEQL 579
Query: 1087 FERGSTDRF 1095
F G D F
Sbjct: 580 FLPGHEDEF 588
>gi|239743562 PREDICTED: hypothetical protein XP_002342894 [Homo
sapiens]
Length = 1029
Score = 108 bits (269), Expect = 4e-23
Identities = 66/183 (36%), Positives = 94/183 (51%), Gaps = 26/183 (14%)
Query: 1 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESY-VLPQSEEGRGGGDNNPLDNLALEQ 59
MN+ +Y P QRWLA +++DG++ RE + + VLP
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLP--------------------- 39
Query: 60 KDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFT 119
T + V + TG NAGT ANV+I++ G + DTG L SK +S F R + F
Sbjct: 40 ---VTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSK-SSFNFLRGQTDTFF 95
Query: 120 VETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIR 179
+E + LGDL K+ +GHD G GWF+D V + P+ F C RWL + EDD I+R
Sbjct: 96 LEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVR 155
Query: 180 DLF 182
+L+
Sbjct: 156 ELY 158
Score = 99.0 bits (245), Expect = 2e-20
Identities = 57/170 (33%), Positives = 87/170 (51%), Gaps = 18/170 (10%)
Query: 301 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 360
P RWLA ++D + RE + + + L + +Y V + TG +
Sbjct: 10 PVQRWLARDQEDGEICREF-----------------PLLSKGQPVLPVTIYEVNVATGEL 52
Query: 361 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 420
AGT A VYI+I+G+ GDTG R L +S++ N F RG DTF +EA LG + KI + H
Sbjct: 53 WNAGTVANVYISIHGEKGDTGSRQLFRSKSSFN-FLRGQTDTFFLEAVHLGDLCKIVIGH 111
Query: 421 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 470
D W+++ V I + T E+ F C RWL ++D ++ R Y ++
Sbjct: 112 DGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
Score = 92.8 bits (229), Expect = 2e-18
Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 1/165 (0%)
Query: 734 MNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDAN 793
MN+G WL++ + + E + + ++ T Y V V T ++ AGT AN
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
Query: 794 VFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPG 853
V+I I GE GD+G+ L +S + F R TDTF F + + LG LCK+ + HD G G
Sbjct: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTF-FLEAVHLGDLCKIVIGHDGLGPGNG 119
Query: 854 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKI 898
W L V +KD + + + F C WL + E D + VR+ +N I
Sbjct: 120 WFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSI 164
Score = 84.3 bits (207), Expect = 6e-16
Identities = 51/157 (32%), Positives = 83/157 (52%), Gaps = 3/157 (1%)
Query: 609 GTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVWTGDVVGGGTDSNIF 668
G ++ + WLA+D+ DG R F LL + V + YE+ V TG++ GT +N++
Sbjct: 4 GKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTI-YEVNVATGELWNAGTVANVY 62
Query: 669 MTLYGINGSTEEMQLDKKKARFE--REQNDTFIMEILDIAPFTKMRIRIDGLGSRPEWFL 726
++++G G T QL + K+ F R Q DTF +E + + K+ I DGLG WFL
Sbjct: 63 ISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFL 122
Query: 727 ERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCA 763
+ +++K+ T F+ WL Q + +V E+ A
Sbjct: 123 DDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYA 159
Score = 77.4 bits (189), Expect = 7e-14
Identities = 56/167 (33%), Positives = 81/167 (48%), Gaps = 9/167 (5%)
Query: 157 GKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIF 216
GK P RWLA++++DG I R+ F + + P YE+ + T +++ AGT AN++
Sbjct: 4 GKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVY 62
Query: 217 IIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNP 276
I I+G + T + L +K F R F +E +G++ KI IGH+ G
Sbjct: 63 ISIHG-EKGDTGSRQLFRSKSSFN--FLRGQTDTFFLEAVHLGDLC-KIVIGHDGLGPGN 118
Query: 277 GWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYD 323
GW V I+ D F C RWL EDD K +REL D
Sbjct: 119 GWFLDDVVIK----DPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
Score = 68.9 bits (167), Expect = 2e-11
Identities = 36/99 (36%), Positives = 56/99 (56%), Gaps = 1/99 (1%)
Query: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 410
Y V ++TG + A T+++V++ ++G+ GD+G R L KS N KF+RG D F + A L
Sbjct: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKS-NMQVKFQRGQIDKFQVAAVSL 694
Query: 411 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLC 449
G + K+ LR + S WY E+V + E +F C
Sbjct: 695 GKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 63.5 bits (153), Expect = 1e-09
Identities = 33/113 (29%), Positives = 58/113 (51%), Gaps = 1/113 (0%)
Query: 514 PIIPYYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVA 573
P+ Y V+V TG+ +A T + +I + GE + R L + F RG + F++
Sbjct: 39 PVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSR-QLFRSKSSFNFLRGQTDTFFLE 97
Query: 574 GLDVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGD 626
+ +G + KI +GHDG P + W ++++ + PT +Y C+ WL + D
Sbjct: 98 AVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDD 150
Score = 62.8 bits (151), Expect = 2e-09
Identities = 105/486 (21%), Positives = 172/486 (35%), Gaps = 142/486 (29%)
Query: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 410
+ V + TGN GT A V + +YGD G TG L K + F G D F
Sbjct: 540 WKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSE-QLFLPGHEDEF------- 588
Query: 411 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 470
++ ++H SK D F WLS + DG +
Sbjct: 589 ----QVTMQHMKSKKILD------------------FAANVWLSRIQADGDVV------- 619
Query: 471 YTGDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDA 530
C P V G A + + Y V V TG+ K A
Sbjct: 620 --------CELPV------------------VKGGQAIFP-----LRYQVDVYTGQLKHA 648
Query: 531 ATDSRAFIFLIGE-DDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDG 589
T+S F+ L GE D ++++ + K F RG +++F VA + +G ++K+ L +
Sbjct: 649 ETESEVFLCLFGERGDSGLRQLYKSNMQVK--FQRGQIDKFQVAAVSLGKLQKVLLRCEA 706
Query: 590 ASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLY 649
+ W E++ + P ++ + C + + F +M+
Sbjct: 707 SDKSQYWYCEQVIVREPGTTSESIFTC---------QSLPAHNFQASPSMLYR------- 750
Query: 650 EMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFT 709
+ TV T ++ G + +G GS L +KKA + I+ + + F
Sbjct: 751 DETVPTSLILKGAEEYGTRNRTWGTAGSF----LLQKKAILK-----PLIVTSVSQSLFC 801
Query: 710 KMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEE 769
+++ +G W + K K++ C +
Sbjct: 802 AYEVKVS--------------------------VHGAWKAVLKRKESHGC--------TQ 827
Query: 770 MMEWT--------SYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFER 821
+EWT + V + T D+ AGT A VF+ ++GE SG + L S F
Sbjct: 828 ELEWTVLAGELDGDWKVTIVTGDLENAGTTATVFLYVYGETKCSGPIIL-GSGKHQLFNP 886
Query: 822 NNTDTF 827
N D F
Sbjct: 887 NTADIF 892
Score = 58.9 bits (141), Expect = 3e-08
Identities = 36/70 (51%), Positives = 44/70 (62%), Gaps = 2/70 (2%)
Query: 1035 SKVQSLVPVK-YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGST 1092
SK Q ++PV YEV V TG AGT ANV+++I G GDTG R+L + K F RG T
Sbjct: 32 SKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQT 91
Query: 1093 DRFFLETLEL 1102
D FFLE + L
Sbjct: 92 DTFFLEAVHL 101
Score = 58.2 bits (139), Expect = 4e-08
Identities = 56/228 (24%), Positives = 93/228 (40%), Gaps = 36/228 (15%)
Query: 649 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL--DKKKARFEREQNDTFIMEILDIA 706
+++ V TG+ GT +N+ + +YG G T + L D + F D F
Sbjct: 540 WKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF-------- 588
Query: 707 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVID 766
++ +++M + + F WLS+ + +VCE+ V
Sbjct: 589 ---------------------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVKG 627
Query: 767 EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDT 826
+ + Y V V T + A T++ VF+ +FGE GDSG L +S KF+R D
Sbjct: 628 GQAIFP-LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDK 686
Query: 827 FNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQC 874
F +SLG L K+ + + W+ V V++ F C
Sbjct: 687 FQVA-AVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 56.6 bits (135), Expect = 1e-07
Identities = 36/106 (33%), Positives = 53/106 (50%), Gaps = 1/106 (0%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
+ V + TG K+A T++ VF+ LFG + D+G+ L S KF+R I+ F V + L
Sbjct: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQV-KFQRGQIDKFQVAAVSL 694
Query: 126 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKN 171
G L KV L + + K+ W+ + V V P F C A N
Sbjct: 695 GKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTCQSLPAHN 740
Score = 55.8 bits (133), Expect = 2e-07
Identities = 40/142 (28%), Positives = 65/142 (45%), Gaps = 11/142 (7%)
Query: 870 FHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETG---NGGETRENVWLI 926
F+ WL++ + DG+ R+F + K L T YE+ + TG N G T NV++
Sbjct: 7 FYVPVQRWLARDQEDGEICREFPLLS-KGQPVLPVTIYEVNVATGELWNAG-TVANVYIS 64
Query: 927 LEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKREL 986
+ G K + + S F +G TDTF ++++LGD+ + +GH D P
Sbjct: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGH----DGLGPGN-- 118
Query: 987 AWHVKTITITEMEYGNVYFFNC 1008
W + + I + Y F C
Sbjct: 119 GWFLDDVVIKDPTTNYEYAFFC 140
Score = 51.6 bits (122), Expect = 4e-06
Identities = 26/66 (39%), Positives = 42/66 (63%), Gaps = 1/66 (1%)
Query: 1038 QSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGSTDRFF 1096
Q++ P++Y+V V TG A T++ VF+ +FG GD+G R+L K M+ F+RG D+F
Sbjct: 629 QAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQ 688
Query: 1097 LETLEL 1102
+ + L
Sbjct: 689 VAAVSL 694
Score = 49.3 bits (116), Expect = 2e-05
Identities = 49/246 (19%), Positives = 98/246 (39%), Gaps = 43/246 (17%)
Query: 768 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTF 827
E ++ + V V T + GT ANV + ++G+ G +G ++L++ ++ F + D F
Sbjct: 532 ETLLSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF 588
Query: 828 NFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQT 887
+++ H+ ++ F + WLS+ + DG
Sbjct: 589 Q----VTMQHMKSKKI--------------------------LDFAANVWLSRIQADGDV 618
Query: 888 VRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQ 945
V + K + Y++ + TG ET V+L L G + S + S+ Q
Sbjct: 619 VCELPVV--KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQ 676
Query: 946 RAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYF 1005
F++G D F+ ++ LG + + + A + + W+ + + + E +
Sbjct: 677 VKFQRGQIDKFQVAAVSLGKLQKVLLRCEASD------KSQYWYCEQVIVREPGTTSESI 730
Query: 1006 FNCDCL 1011
F C L
Sbjct: 731 FTCQSL 736
Score = 40.8 bits (94), Expect = 0.007
Identities = 44/221 (19%), Positives = 95/221 (42%), Gaps = 39/221 (17%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
+ V + TG N GT ANV + ++G + TG L+ +DS E +
Sbjct: 540 WKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLR----------KDSSEQLFLP---- 582
Query: 126 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAE 185
GH++ + V + K + F WL++ + DG ++ +L +
Sbjct: 583 --------GHEDEFQ--------VTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVK 626
Query: 186 LQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFER 245
++ + Y++ +YT + A T++ +F+ ++G ++ +N + + F+R
Sbjct: 627 GGQAIFP--LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVK---FQR 681
Query: 246 KSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIR 286
+F V +G+ ++K+ + + + W+C V +R
Sbjct: 682 GQIDKFQVAAVSLGK-LQKVLLRCEASDKSQYWYCEQVIVR 721
Score = 33.5 bits (75), Expect = 1.2
Identities = 20/53 (37%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIF 118
+ VTI TG +NAGT A VF+ ++G +G +L S K F ++ +IF
Sbjct: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGK--HQLFNPNTADIF 892
Score = 32.7 bits (73), Expect = 2.0
Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 4/69 (5%)
Query: 1028 KTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNL 1086
K F S L +++V+V TG GT ANV + ++G G TG L K L
Sbjct: 523 KEIRHFQSSETLLSEDEWKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLRKDSSEQL 579
Query: 1087 FERGSTDRF 1095
F G D F
Sbjct: 580 FLPGHEDEF 588
>gi|19923084 polycystin-1L1 [Homo sapiens]
Length = 2849
Score = 79.3 bits (194), Expect = 2e-14
Identities = 43/118 (36%), Positives = 61/118 (51%), Gaps = 1/118 (0%)
Query: 776 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 835
Y V + T A + V+I++ G+NG S T L FERN+ TF L
Sbjct: 1798 YAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEK-PLFERNSRHTFILSAPAQL 1856
Query: 836 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFAC 893
G L K+R+WHD++G PGW +S+V VK+ + + F CWLS DG+ R+ C
Sbjct: 1857 GLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVERELTC 1914
Score = 63.9 bits (154), Expect = 8e-10
Identities = 42/118 (35%), Positives = 59/118 (50%), Gaps = 5/118 (4%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKS-SKTNSDKFERDSIEIFTVET-L 123
++V I TG + A + V+I L G D G++ K S FER+S F +
Sbjct: 1798 YAVVIDTGFRAPARLTSKVYIVLCG---DNGLSETKELSCPEKPLFERNSRHTFILSAPA 1854
Query: 124 DLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDL 181
LG L K+RL HD+ G +PGWF+ V V G+ FP WL+ DG + R+L
Sbjct: 1855 QLGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVEREL 1912
Score = 60.5 bits (145), Expect = 9e-09
Identities = 42/116 (36%), Positives = 59/116 (50%), Gaps = 3/116 (2%)
Query: 350 LYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEA-A 408
LY+V I TG A +KVYI + GD G + + L E FER + TFI+ A A
Sbjct: 1797 LYAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPL--FERNSRHTFILSAPA 1854
Query: 409 DLGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLER 464
LG++ KI+L HD+ W++ V + + F WLS + DGR+ER
Sbjct: 1855 QLGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVER 1910
Score = 54.7 bits (130), Expect = 5e-07
Identities = 33/123 (26%), Positives = 57/123 (46%), Gaps = 8/123 (6%)
Query: 197 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELE 256
Y + + T A + ++I++ G + + ++ C +K FER S FI+
Sbjct: 1798 YAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCP----EKPLFERNSRHTFILSAP 1853
Query: 257 DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTI 316
++ KIR+ H++ G +PGW SHV ++ L + FP WL+ D +
Sbjct: 1854 AQLGLLRKIRLWHDSRGPSPGWFISHVMVKEL----HTGQGWFFPAQCWLSAGRHDGRVE 1909
Query: 317 REL 319
REL
Sbjct: 1910 REL 1912
Score = 52.4 bits (124), Expect = 2e-06
Identities = 32/104 (30%), Positives = 50/104 (48%), Gaps = 2/104 (1%)
Query: 648 LYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLD-KKKARFEREQNDTFIMEI-LDI 705
LY + + TG S +++ L G NG +E +L +K FER TFI+ +
Sbjct: 1797 LYAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPLFERNSRHTFILSAPAQL 1856
Query: 706 APFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 749
K+R+ D G P WF+ +++K ++TG F WLS
Sbjct: 1857 GLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLS 1900
Score = 49.7 bits (117), Expect = 2e-05
Identities = 35/115 (30%), Positives = 50/115 (43%), Gaps = 3/115 (2%)
Query: 518 YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYV-AGLD 576
Y V + TG A S+ +I L G D+ S+ L P K F R S F + A
Sbjct: 1798 YAVVIDTGFRAPARLTSKVYIVLCG-DNGLSETKELSCPE-KPLFERNSRHTFILSAPAQ 1855
Query: 577 VGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSR 631
+G+++KI L HD P W + + + G + CWL+ R DG R
Sbjct: 1856 LGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVER 1910
Score = 36.6 bits (83), Expect = 0.14
Identities = 18/53 (33%), Positives = 28/53 (52%)
Query: 1045 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFL 1097
Y V++ TG+ A + V++ + G NG + +EL + LFER S F L
Sbjct: 1798 YAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPLFERNSRHTFIL 1850
>gi|239756622 PREDICTED: polycystic kidney disease 1-like 3 [Homo
sapiens]
Length = 1732
Score = 79.0 bits (193), Expect = 2e-14
Identities = 49/155 (31%), Positives = 71/155 (45%), Gaps = 5/155 (3%)
Query: 776 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 835
Y + V T A T A V I ++G G S L FER D F SL
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK-TVFERGGLDVFLLTTWTSL 803
Query: 836 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACAN 895
G+L LR+WHDN G+ P W++S V V D + +HF C+CWL+ GD + R F +
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPVS 863
Query: 896 NKICDELEETTYEIVIETGNGGETRENVWLILEGR 930
+ +++E T++ +WL + R
Sbjct: 864 KRELFSFRHLFSSMIVEK----FTQDYLWLSIATR 894
Score = 73.2 bits (178), Expect = 1e-12
Identities = 41/117 (35%), Positives = 65/117 (55%), Gaps = 3/117 (2%)
Query: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEA-AD 409
Y +Q++TG A T AKV IT+YG G + +L + + FERG D F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL--CDPQKTVFERGGLDVFLLTTWTS 802
Query: 410 LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLF 466
LG ++ ++L HDNS WYV +V + + + ++ FLC WL++ D L+R+F
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVF 859
Score = 62.0 bits (149), Expect = 3e-09
Identities = 44/127 (34%), Positives = 66/127 (51%), Gaps = 7/127 (5%)
Query: 57 LEQKDKSTTFSVTIK--TGVKKNAGTDANVFITLFGTQDDTGMT-LLKSSKTNSDKFERD 113
L D S F I+ TG +++A T A V ITL+G++ + L KT FER
Sbjct: 734 LADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKT---VFERG 790
Query: 114 SIEIFTVET-LDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNE 172
+++F + T LG+L +RL HDN+G +P W+V V V ++ + F C WLA +
Sbjct: 791 GLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDL 850
Query: 173 DDGSIIR 179
D + R
Sbjct: 851 GDCELDR 857
Score = 57.4 bits (137), Expect = 7e-08
Identities = 38/117 (32%), Positives = 56/117 (47%), Gaps = 3/117 (2%)
Query: 518 YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAG-LD 576
Y + V TG + AAT ++ I L G + RS+ L P+ K F RG ++ F +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEG-RSEPHHLCDPQ-KTVFERGGLDVFLLTTWTS 802
Query: 577 VGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVF 633
+G + + L HD + W V ++ + K+ CNCWLA D GD RVF
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVF 859
Score = 49.7 bits (117), Expect = 2e-05
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 197 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELE 256
Y I +YT +A T A + I +YG + ++ +LC QK FER F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGR-SEPHHLCD---PQKTVFERGGLDVFLLTTW 800
Query: 257 DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTI 316
+ +R+ H+N+G++P W+ S V ++ D F C+ WLA D +
Sbjct: 801 TSLGNLHSLRLWHDNSGVSPSWYVSQV----IVCDMAVKRKWHFLCNCWLAVDLGDCELD 856
Query: 317 RELVP 321
R +P
Sbjct: 857 RVFIP 861
Score = 43.9 bits (102), Expect = 9e-04
Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 2/103 (1%)
Query: 649 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEI-LDIA 706
Y + V+TG T + + +TLYG G +E L D +K FER D F++ +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 707 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 749
+R+ D G P W++ ++++ +M F WL+
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLA 847
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/55 (38%), Positives = 29/55 (52%)
Query: 1045 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET 1099
Y + V TGY A T A V +T++G+ G + L + +FERG D F L T
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTT 799
>gi|239751108 PREDICTED: polycystic kidney disease 1-like 3 [Homo
sapiens]
Length = 1731
Score = 79.0 bits (193), Expect = 2e-14
Identities = 49/155 (31%), Positives = 71/155 (45%), Gaps = 5/155 (3%)
Query: 776 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 835
Y + V T A T A V I ++G G S L FER D F SL
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK-TVFERGGLDVFLLTTWTSL 803
Query: 836 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACAN 895
G+L LR+WHDN G+ P W++S V V D + +HF C+CWL+ GD + R F +
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPVS 863
Query: 896 NKICDELEETTYEIVIETGNGGETRENVWLILEGR 930
+ +++E T++ +WL + R
Sbjct: 864 KRELFSFRHLFSSMIVEK----FTQDYLWLSIATR 894
Score = 73.2 bits (178), Expect = 1e-12
Identities = 41/117 (35%), Positives = 65/117 (55%), Gaps = 3/117 (2%)
Query: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEA-AD 409
Y +Q++TG A T AKV IT+YG G + +L + + FERG D F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL--CDPQKTVFERGGLDVFLLTTWTS 802
Query: 410 LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLF 466
LG ++ ++L HDNS WYV +V + + + ++ FLC WL++ D L+R+F
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVF 859
Score = 62.0 bits (149), Expect = 3e-09
Identities = 44/127 (34%), Positives = 66/127 (51%), Gaps = 7/127 (5%)
Query: 57 LEQKDKSTTFSVTIK--TGVKKNAGTDANVFITLFGTQDDTGMT-LLKSSKTNSDKFERD 113
L D S F I+ TG +++A T A V ITL+G++ + L KT FER
Sbjct: 734 LADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKT---VFERG 790
Query: 114 SIEIFTVET-LDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNE 172
+++F + T LG+L +RL HDN+G +P W+V V V ++ + F C WLA +
Sbjct: 791 GLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDL 850
Query: 173 DDGSIIR 179
D + R
Sbjct: 851 GDCELDR 857
Score = 57.4 bits (137), Expect = 7e-08
Identities = 38/117 (32%), Positives = 56/117 (47%), Gaps = 3/117 (2%)
Query: 518 YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAG-LD 576
Y + V TG + AAT ++ I L G + RS+ L P+ K F RG ++ F +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEG-RSEPHHLCDPQ-KTVFERGGLDVFLLTTWTS 802
Query: 577 VGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVF 633
+G + + L HD + W V ++ + K+ CNCWLA D GD RVF
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVF 859
Score = 49.7 bits (117), Expect = 2e-05
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 197 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELE 256
Y I +YT +A T A + I +YG + ++ +LC QK FER F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGR-SEPHHLCD---PQKTVFERGGLDVFLLTTW 800
Query: 257 DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTI 316
+ +R+ H+N+G++P W+ S V ++ D F C+ WLA D +
Sbjct: 801 TSLGNLHSLRLWHDNSGVSPSWYVSQV----IVCDMAVKRKWHFLCNCWLAVDLGDCELD 856
Query: 317 RELVP 321
R +P
Sbjct: 857 RVFIP 861
Score = 43.9 bits (102), Expect = 9e-04
Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 2/103 (1%)
Query: 649 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEI-LDIA 706
Y + V+TG T + + +TLYG G +E L D +K FER D F++ +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 707 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 749
+R+ D G P W++ ++++ +M F WL+
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLA 847
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/55 (38%), Positives = 29/55 (52%)
Query: 1045 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET 1099
Y + V TGY A T A V +T++G+ G + L + +FERG D F L T
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTT 799
>gi|239745596 PREDICTED: polycystin 1-like 3 [Homo sapiens]
Length = 1731
Score = 79.0 bits (193), Expect = 2e-14
Identities = 49/155 (31%), Positives = 71/155 (45%), Gaps = 5/155 (3%)
Query: 776 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 835
Y + V T A T A V I ++G G S L FER D F SL
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK-TVFERGGLDVFLLTTWTSL 803
Query: 836 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACAN 895
G+L LR+WHDN G+ P W++S V V D + +HF C+CWL+ GD + R F +
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPVS 863
Query: 896 NKICDELEETTYEIVIETGNGGETRENVWLILEGR 930
+ +++E T++ +WL + R
Sbjct: 864 KRELFSFRHLFSSMIVEK----FTQDYLWLSIATR 894
Score = 73.2 bits (178), Expect = 1e-12
Identities = 41/117 (35%), Positives = 65/117 (55%), Gaps = 3/117 (2%)
Query: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEA-AD 409
Y +Q++TG A T AKV IT+YG G + +L + + FERG D F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL--CDPQKTVFERGGLDVFLLTTWTS 802
Query: 410 LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLF 466
LG ++ ++L HDNS WYV +V + + + ++ FLC WL++ D L+R+F
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVF 859
Score = 62.0 bits (149), Expect = 3e-09
Identities = 44/127 (34%), Positives = 66/127 (51%), Gaps = 7/127 (5%)
Query: 57 LEQKDKSTTFSVTIK--TGVKKNAGTDANVFITLFGTQDDTGMT-LLKSSKTNSDKFERD 113
L D S F I+ TG +++A T A V ITL+G++ + L KT FER
Sbjct: 734 LADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKT---VFERG 790
Query: 114 SIEIFTVET-LDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNE 172
+++F + T LG+L +RL HDN+G +P W+V V V ++ + F C WLA +
Sbjct: 791 GLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDL 850
Query: 173 DDGSIIR 179
D + R
Sbjct: 851 GDCELDR 857
Score = 57.4 bits (137), Expect = 7e-08
Identities = 38/117 (32%), Positives = 56/117 (47%), Gaps = 3/117 (2%)
Query: 518 YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAG-LD 576
Y + V TG + AAT ++ I L G + RS+ L P+ K F RG ++ F +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEG-RSEPHHLCDPQ-KTVFERGGLDVFLLTTWTS 802
Query: 577 VGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVF 633
+G + + L HD + W V ++ + K+ CNCWLA D GD RVF
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVF 859
Score = 49.7 bits (117), Expect = 2e-05
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 197 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELE 256
Y I +YT +A T A + I +YG + ++ +LC QK FER F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGR-SEPHHLCD---PQKTVFERGGLDVFLLTTW 800
Query: 257 DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTI 316
+ +R+ H+N+G++P W+ S V ++ D F C+ WLA D +
Sbjct: 801 TSLGNLHSLRLWHDNSGVSPSWYVSQV----IVCDMAVKRKWHFLCNCWLAVDLGDCELD 856
Query: 317 RELVP 321
R +P
Sbjct: 857 RVFIP 861
Score = 43.9 bits (102), Expect = 9e-04
Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 2/103 (1%)
Query: 649 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEI-LDIA 706
Y + V+TG T + + +TLYG G +E L D +K FER D F++ +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 707 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 749
+R+ D G P W++ ++++ +M F WL+
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLA 847
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/55 (38%), Positives = 29/55 (52%)
Query: 1045 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET 1099
Y + V TGY A T A V +T++G+ G + L + +FERG D F L T
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTT 799
>gi|31559825 polycystin 1-like 3 [Homo sapiens]
Length = 1732
Score = 79.0 bits (193), Expect = 2e-14
Identities = 49/155 (31%), Positives = 71/155 (45%), Gaps = 5/155 (3%)
Query: 776 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 835
Y + V T A T A V I ++G G S L FER D F SL
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK-TVFERGGLDVFLLTTWTSL 803
Query: 836 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACAN 895
G+L LR+WHDN G+ P W++S V V D + +HF C+CWL+ GD + R F +
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPVS 863
Query: 896 NKICDELEETTYEIVIETGNGGETRENVWLILEGR 930
+ +++E T++ +WL + R
Sbjct: 864 KRELFSFRHLFSSMIVEK----FTQDYLWLSIATR 894
Score = 73.2 bits (178), Expect = 1e-12
Identities = 41/117 (35%), Positives = 65/117 (55%), Gaps = 3/117 (2%)
Query: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEA-AD 409
Y +Q++TG A T AKV IT+YG G + +L + + FERG D F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL--CDPQKTVFERGGLDVFLLTTWTS 802
Query: 410 LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLF 466
LG ++ ++L HDNS WYV +V + + + ++ FLC WL++ D L+R+F
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVF 859
Score = 62.0 bits (149), Expect = 3e-09
Identities = 44/127 (34%), Positives = 66/127 (51%), Gaps = 7/127 (5%)
Query: 57 LEQKDKSTTFSVTIK--TGVKKNAGTDANVFITLFGTQDDTGMT-LLKSSKTNSDKFERD 113
L D S F I+ TG +++A T A V ITL+G++ + L KT FER
Sbjct: 734 LADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKT---VFERG 790
Query: 114 SIEIFTVET-LDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNE 172
+++F + T LG+L +RL HDN+G +P W+V V V ++ + F C WLA +
Sbjct: 791 GLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDL 850
Query: 173 DDGSIIR 179
D + R
Sbjct: 851 GDCELDR 857
Score = 57.4 bits (137), Expect = 7e-08
Identities = 38/117 (32%), Positives = 56/117 (47%), Gaps = 3/117 (2%)
Query: 518 YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAG-LD 576
Y + V TG + AAT ++ I L G + RS+ L P+ K F RG ++ F +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEG-RSEPHHLCDPQ-KTVFERGGLDVFLLTTWTS 802
Query: 577 VGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVF 633
+G + + L HD + W V ++ + K+ CNCWLA D GD RVF
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVF 859
Score = 49.7 bits (117), Expect = 2e-05
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 197 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELE 256
Y I +YT +A T A + I +YG + ++ +LC QK FER F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGR-SEPHHLCD---PQKTVFERGGLDVFLLTTW 800
Query: 257 DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTI 316
+ +R+ H+N+G++P W+ S V ++ D F C+ WLA D +
Sbjct: 801 TSLGNLHSLRLWHDNSGVSPSWYVSQV----IVCDMAVKRKWHFLCNCWLAVDLGDCELD 856
Query: 317 RELVP 321
R +P
Sbjct: 857 RVFIP 861
Score = 43.9 bits (102), Expect = 9e-04
Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 2/103 (1%)
Query: 649 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEI-LDIA 706
Y + V+TG T + + +TLYG G +E L D +K FER D F++ +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 707 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 749
+R+ D G P W++ ++++ +M F WL+
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLA 847
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/55 (38%), Positives = 29/55 (52%)
Query: 1045 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET 1099
Y + V TGY A T A V +T++G+ G + L + +FERG D F L T
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTT 799
>gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens]
Length = 2459
Score = 76.3 bits (186), Expect = 2e-13
Identities = 43/127 (33%), Positives = 69/127 (54%), Gaps = 3/127 (2%)
Query: 341 EVEEPLDIVLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTA 400
E +P Y V ++TG+ GA T +KV +T+YG G+ +L + T FERG
Sbjct: 1382 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPD--TPVFERGAV 1439
Query: 401 DTFIIEAA-DLGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKED 459
D F++ LG + ++L HDNS WYV +V +++ + ++ FLC WLS+ D
Sbjct: 1440 DAFLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGD 1499
Query: 460 GRLERLF 466
L+++F
Sbjct: 1500 CVLDKVF 1506
Score = 72.4 bits (176), Expect = 2e-12
Identities = 43/136 (31%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Query: 749 SQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTL 808
++RK + V+++ + Y V V T GA T + V + ++G +G+
Sbjct: 1365 ARRKDAQDQAKVKVTVLEDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPH 1424
Query: 809 ALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDE 868
L + FER D F + LG L LR+WHDN G P W++S V V D D
Sbjct: 1425 HLADP-DTPVFERGAVDAFLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDR 1483
Query: 869 TFHFQCDCWLSKSEGD 884
++F C+ WLS + GD
Sbjct: 1484 KWYFLCNSWLSINVGD 1499
Score = 62.8 bits (151), Expect = 2e-09
Identities = 38/110 (34%), Positives = 57/110 (51%), Gaps = 3/110 (2%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETL-D 124
+ VT+ TG ++ A T + V +TL+G + L T FER +++ F + TL
Sbjct: 1392 YLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDT--PVFERGAVDAFLLSTLFP 1449
Query: 125 LGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDD 174
LG+L +RL HDN+G P W+V V V + + F C WL+ N D
Sbjct: 1450 LGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGD 1499
Score = 59.3 bits (142), Expect = 2e-08
Identities = 41/137 (29%), Positives = 64/137 (46%), Gaps = 4/137 (2%)
Query: 649 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEIL-DIA 706
Y +TV+TG G T S + +TLYG++G E L D FER D F++ L +
Sbjct: 1392 YLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDAFLLSTLFPLG 1451
Query: 707 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVID 766
+R+ D G RP W++ R+L+ ++ F WLS G V + +
Sbjct: 1452 ELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVG--DCVLDKVFPVA 1509
Query: 767 EEEMMEWTSYTVAVKTS 783
E+ + S+ +KTS
Sbjct: 1510 TEQDRKQFSHLFFMKTS 1526
Score = 58.2 bits (139), Expect = 4e-08
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 3/117 (2%)
Query: 518 YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGL-D 576
Y V+V TG + AAT S+ + L G D ER D F RG+V+ F ++ L
Sbjct: 1392 YLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPV--FERGAVDAFLLSTLFP 1449
Query: 577 VGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVF 633
+G ++ + L HD + W V + + K+ CN WL+ + GD + +VF
Sbjct: 1450 LGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCVLDKVF 1506
Score = 46.2 bits (108), Expect = 2e-04
Identities = 34/123 (27%), Positives = 58/123 (47%), Gaps = 12/123 (9%)
Query: 193 PFVPYE--ITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASR 250
PF Y +T+YT A T + + + +YG D + +L FER +
Sbjct: 1386 PFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGE-REPHHLAD---PDTPVFERGAVDA 1441
Query: 251 FIVE-LEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATS 309
F++ L +GE+ +R+ H+N+G P W+ S V + L+ D+ F C+ WL+ +
Sbjct: 1442 FLLSTLFPLGEL-RSLRLWHDNSGDRPSWYVSRVLVYDLVMDR----KWYFLCNSWLSIN 1496
Query: 310 EDD 312
D
Sbjct: 1497 VGD 1499
Score = 45.4 bits (106), Expect = 3e-04
Identities = 23/56 (41%), Positives = 31/56 (55%)
Query: 1045 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETL 1100
Y V V TG+ GA T + V VT++G +G+ L +FERG+ D F L TL
Sbjct: 1392 YLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDAFLLSTL 1447
>gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens]
Length = 4302
Score = 75.1 bits (183), Expect = 3e-13
Identities = 52/161 (32%), Positives = 79/161 (49%), Gaps = 7/161 (4%)
Query: 776 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 835
Y + VKT G+GT A+V I+++G + SG L F RN+ D F SL
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGD---RAFHRNSLDIFRIATPHSL 3176
Query: 836 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLS-KSEGDGQTVRDFACA 894
G + K+RVWHDNKG+ P W L +V V+D + F + WLS ++E +G V A
Sbjct: 3177 GSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLA 3236
Query: 895 NNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSK 935
+ D +++ G +++WL + R RS+
Sbjct: 3237 AS---DAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSR 3274
Score = 66.2 bits (160), Expect = 2e-10
Identities = 37/115 (32%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETL-D 124
+ + +KTG + +GT A+V I L+G +G L + F R+S++IF + T
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA----FHRNSLDIFRIATPHS 3175
Query: 125 LGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLA-KNEDDGSII 178
LG +WK+R+ HDN G +P WF+ V V + F WL+ + E +G ++
Sbjct: 3176 LGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLV 3230
Score = 57.4 bits (137), Expect = 7e-08
Identities = 33/102 (32%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 649 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTF-IMEILDIAP 707
YE+ V TG G GT +++ + LYG++ + LD +A F R D F I +
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA-FHRNSLDIFRIATPHSLGS 3178
Query: 708 FTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 749
K+R+ D G P WFL+ ++++++ T F DWLS
Sbjct: 3179 VWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLS 3220
Score = 51.6 bits (122), Expect = 4e-06
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 5/109 (4%)
Query: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAA-D 409
Y + + TG G+GT A V I +YG +G R+L + F R + D F I
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHL----DGDRAFHRNSLDIFRIATPHS 3175
Query: 410 LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKE 458
LG ++KI++ HDN W+++ V + + FL WLS++ E
Sbjct: 3176 LGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETE 3224
Score = 45.4 bits (106), Expect = 3e-04
Identities = 31/115 (26%), Positives = 52/115 (45%), Gaps = 10/115 (8%)
Query: 197 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELE 256
YEI + T +GT A++ I++YG D+ + + + F R S F +
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHL------DGDRAFHRNSLDIFRIATP 3173
Query: 257 DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSED 311
+ KIR+ H+N G++P W HV +R D A + F + WL+ +
Sbjct: 3174 HSLGSVWKIRVWHDNKGLSPAWFLQHVIVR----DLQTARSAFFLVNDWLSVETE 3224
Score = 40.0 bits (92), Expect = 0.012
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Query: 1044 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET 1099
KYE++V TG+ G+GT A+V + ++G + +G R L F R S D F + T
Sbjct: 3119 KYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGD--RAFHRNSLDIFRIAT 3172
>gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens]
Length = 4303
Score = 75.1 bits (183), Expect = 3e-13
Identities = 52/161 (32%), Positives = 79/161 (49%), Gaps = 7/161 (4%)
Query: 776 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 835
Y + VKT G+GT A+V I+++G + SG L F RN+ D F SL
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGD---RAFHRNSLDIFRIATPHSL 3176
Query: 836 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLS-KSEGDGQTVRDFACA 894
G + K+RVWHDNKG+ P W L +V V+D + F + WLS ++E +G V A
Sbjct: 3177 GSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLA 3236
Query: 895 NNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSK 935
+ D +++ G +++WL + R RS+
Sbjct: 3237 AS---DAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSR 3274
Score = 66.2 bits (160), Expect = 2e-10
Identities = 37/115 (32%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETL-D 124
+ + +KTG + +GT A+V I L+G +G L + F R+S++IF + T
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA----FHRNSLDIFRIATPHS 3175
Query: 125 LGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLA-KNEDDGSII 178
LG +WK+R+ HDN G +P WF+ V V + F WL+ + E +G ++
Sbjct: 3176 LGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLV 3230
Score = 57.4 bits (137), Expect = 7e-08
Identities = 33/102 (32%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 649 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTF-IMEILDIAP 707
YE+ V TG G GT +++ + LYG++ + LD +A F R D F I +
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA-FHRNSLDIFRIATPHSLGS 3178
Query: 708 FTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 749
K+R+ D G P WFL+ ++++++ T F DWLS
Sbjct: 3179 VWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLS 3220
Score = 51.6 bits (122), Expect = 4e-06
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 5/109 (4%)
Query: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAA-D 409
Y + + TG G+GT A V I +YG +G R+L + F R + D F I
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHL----DGDRAFHRNSLDIFRIATPHS 3175
Query: 410 LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKE 458
LG ++KI++ HDN W+++ V + + FL WLS++ E
Sbjct: 3176 LGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETE 3224
Score = 45.4 bits (106), Expect = 3e-04
Identities = 31/115 (26%), Positives = 52/115 (45%), Gaps = 10/115 (8%)
Query: 197 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELE 256
YEI + T +GT A++ I++YG D+ + + + F R S F +
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHL------DGDRAFHRNSLDIFRIATP 3173
Query: 257 DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSED 311
+ KIR+ H+N G++P W HV +R D A + F + WL+ +
Sbjct: 3174 HSLGSVWKIRVWHDNKGLSPAWFLQHVIVR----DLQTARSAFFLVNDWLSVETE 3224
Score = 40.0 bits (92), Expect = 0.012
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Query: 1044 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET 1099
KYE++V TG+ G+GT A+V + ++G + +G R L F R S D F + T
Sbjct: 3119 KYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGD--RAFHRNSLDIFRIAT 3172
>gi|5174633 receptor for egg jelly-like protein precursor [Homo
sapiens]
Length = 2253
Score = 69.7 bits (169), Expect = 1e-11
Identities = 40/125 (32%), Positives = 70/125 (56%), Gaps = 6/125 (4%)
Query: 344 EPLDIVLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTF 403
+P D + Y V IFTG+ G+GT A V++ + G + + L T RG+ +TF
Sbjct: 1225 DPYDNLCYLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTT--LYRGSINTF 1282
Query: 404 IIEA-ADLGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRL 462
++ +DLG I+ I++ H+N WY+ ++++ N + +LF+C +WLS+ D L
Sbjct: 1283 LLTTKSDLGDIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWLSV---DTTL 1339
Query: 463 ERLFY 467
+R F+
Sbjct: 1340 DRTFH 1344
Score = 67.0 bits (162), Expect = 9e-11
Identities = 42/123 (34%), Positives = 64/123 (52%), Gaps = 12/123 (9%)
Query: 48 DNNPLDNLALEQKDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNS 107
DN+P DNL + VTI TG + +GT ANVF+ L GT + + L S +
Sbjct: 1223 DNDPYDNLC---------YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCL--SHPHF 1271
Query: 108 DKFERDSIEIFTVETL-DLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGR 166
R SI F + T DLGD+ +R+ H+N G++P W++ ++V+ F C +
Sbjct: 1272 TTLYRGSINTFLLTTKSDLGDIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQK 1331
Query: 167 WLA 169
WL+
Sbjct: 1332 WLS 1334
Score = 60.5 bits (145), Expect = 9e-09
Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 1/116 (0%)
Query: 764 VIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNN 823
V+ + + + Y V + T G+GT ANVF+ + G S L ++ R +
Sbjct: 1220 VLPDNDPYDNLCYLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHP-HFTTLYRGS 1278
Query: 824 TDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLS 879
+TF LG + +RVWH+N+G P W+LS + V++ + F C WLS
Sbjct: 1279 INTFLLTTKSDLGDIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWLS 1334
Score = 53.5 bits (127), Expect = 1e-06
Identities = 36/137 (26%), Positives = 60/137 (43%), Gaps = 18/137 (13%)
Query: 197 YEITLYTSDVFAAGTDANIFIIIYGC----DAVCTQQKYLCTNKREQKQFFERKSASRFI 252
Y +T++T + +GT AN+F+ + G D C + T R S + F+
Sbjct: 1232 YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTT--------LYRGSINTFL 1283
Query: 253 VELE-DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSED 311
+ + D+G+I IR+ HNN G +P W+ S + + L F C +WL+
Sbjct: 1284 LTTKSDLGDI-HSIRVWHNNEGRSPSWYLSRIKVENLF----SRHIWLFICQKWLSVDTT 1338
Query: 312 DKKTIRELVPYDIFTEK 328
+T P + T K
Sbjct: 1339 LDRTFHVTHPDERLTRK 1355
Score = 45.1 bits (105), Expect = 4e-04
Identities = 28/103 (27%), Positives = 51/103 (49%), Gaps = 2/103 (1%)
Query: 649 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKK-ARFEREQNDTFIMEIL-DIA 706
Y +T++TG G GT +N+F+ L G +++ L R +TF++ D+
Sbjct: 1232 YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFLLTTKSDLG 1291
Query: 707 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 749
+R+ + G P W+L RI ++N+ + + +F WLS
Sbjct: 1292 DIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWLS 1334
Score = 31.6 bits (70), Expect = 4.4
Identities = 20/55 (36%), Positives = 25/55 (45%)
Query: 1045 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET 1099
Y V + TG G+GT ANVFV + G + L RGS + F L T
Sbjct: 1232 YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFLLTT 1286
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 65.9 bits (159), Expect = 2e-10
Identities = 46/122 (37%), Positives = 60/122 (49%), Gaps = 12/122 (9%)
Query: 67 SVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLG 126
SV I NA +N +I + G DTG+ + ++ +E+ T E +LG
Sbjct: 940 SVIIPIKKLSNAIITSNPWICVSGELGDTGVM----------QIPKNLLEM-TFECQNLG 988
Query: 127 DLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAEL 186
L V++GHDN+G W VD V V G FPCGRWL K DDGS+ R L EL
Sbjct: 989 KLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERILI-GEL 1047
Query: 187 QT 188
T
Sbjct: 1048 MT 1049
Score = 60.5 bits (145), Expect = 9e-09
Identities = 47/152 (30%), Positives = 72/152 (47%), Gaps = 22/152 (14%)
Query: 370 YITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRHDNSKWCADW 429
+I + G+LGDTG + K N E TF E +LG + +++ HDNS A W
Sbjct: 958 WICVSGELGDTGVMQIPK-----NLLEM----TF--ECQNLGKLTTVQIGHDNSGLLAKW 1006
Query: 430 YVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTG----DRSSNCSSPADF 485
V+ V + N+ + F CGRWL +DG LER+ + T D C +P
Sbjct: 1007 LVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERILIGELMTSASDEDLVKQCRTPPQQ 1066
Query: 486 WEIALSSKMADVDISTVTG----PMADYVQEG 513
+ +++ I+++TG P A +QEG
Sbjct: 1067 KSPTTARRLS---ITSLTGKNNKPNAGQIQEG 1095
Score = 52.0 bits (123), Expect = 3e-06
Identities = 31/113 (27%), Positives = 50/113 (44%), Gaps = 11/113 (9%)
Query: 777 TVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLG 836
+V + + A +N +I + GE GD+G + + ++ FE N LG
Sbjct: 940 SVIIPIKKLSNAIITSNPWICVSGELGDTGVMQIPKNLLEMTFECQN-----------LG 988
Query: 837 HLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVR 889
L +++ HDN G+ W + V V++ T+ F C WL K DG R
Sbjct: 989 KLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLER 1041
Score = 38.1 bits (87), Expect = 0.047
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 5/75 (6%)
Query: 246 KSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRW 305
K+ E +++G++ ++IGH+N+G+ W V +R + T FPC RW
Sbjct: 975 KNLLEMTFECQNLGKLTT-VQIGHDNSGLLAKWLVDCVMVRNEIT----GHTYRFPCGRW 1029
Query: 306 LATSEDDKKTIRELV 320
L DD R L+
Sbjct: 1030 LGKGIDDGSLERILI 1044
Score = 35.8 bits (81), Expect = 0.23
Identities = 16/57 (28%), Positives = 28/57 (49%)
Query: 576 DVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRV 632
++G + +++GHD + + WLV+ + + G Y C WL K DG R+
Sbjct: 986 NLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERI 1042
Score = 33.5 bits (75), Expect = 1.2
Identities = 17/32 (53%), Positives = 19/32 (59%), Gaps = 3/32 (9%)
Query: 1 MNNEIT---YYFPCQRWLAVEEDDGQLSRELL 29
+ NEIT Y FPC RWL DDG L R L+
Sbjct: 1013 VRNEITGHTYRFPCGRWLGKGIDDGSLERILI 1044
Score = 32.3 bits (72), Expect = 2.6
Identities = 28/114 (24%), Positives = 52/114 (45%), Gaps = 16/114 (14%)
Query: 665 SNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEW 724
SN ++ + G G T MQ+ K TF E ++ T ++I D G +W
Sbjct: 955 SNPWICVSGELGDTGVMQIPKNLLEM------TF--ECQNLGKLTTVQIGHDNSGLLAKW 1006
Query: 725 FLERILLKNMNTGDLTMFYYGDWLSQRKG------KKTLVCEMCAVIDEEEMME 772
++ ++++N TG F G WL KG ++ L+ E+ +E++++
Sbjct: 1007 LVDCVMVRNEITGHTYRFPCGRWLG--KGIDDGSLERILIGELMTSASDEDLVK 1058
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 61.6 bits (148), Expect = 4e-09
Identities = 33/78 (42%), Positives = 45/78 (57%), Gaps = 1/78 (1%)
Query: 104 KTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFP 163
+T + R+ +E+ T E +LG L V++GHDN+G W V++V V G FP
Sbjct: 985 ETQIMQIPRNVLEM-TFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFP 1043
Query: 164 CGRWLAKNEDDGSIIRDL 181
CGRWL K DDGS+ R L
Sbjct: 1044 CGRWLGKGMDDGSLERIL 1061
Score = 53.9 bits (128), Expect = 8e-07
Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 11/114 (9%)
Query: 776 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 835
+ + V + + G+ AN +I I GE G++ + + ++ FE N L
Sbjct: 957 HILIVPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTFECQN-----------L 1005
Query: 836 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVR 889
G L +++ HDN G++ W + YV V++ T+ F C WL K DG R
Sbjct: 1006 GKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLER 1059
Score = 53.5 bits (127), Expect = 1e-06
Identities = 36/104 (34%), Positives = 52/104 (50%), Gaps = 11/104 (10%)
Query: 362 GAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRHD 421
G+ A +I I G+LG+T + + N E TF E +LG + +++ HD
Sbjct: 968 GSMFTANPWICISGELGETQIMQIPR-----NVLEM----TF--ECQNLGKLTTVQIGHD 1016
Query: 422 NSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERL 465
NS A W VE V + N+ + F CGRWL +DG LER+
Sbjct: 1017 NSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERI 1060
Score = 40.8 bits (94), Expect = 0.007
Identities = 22/67 (32%), Positives = 35/67 (52%), Gaps = 5/67 (7%)
Query: 254 ELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDK 313
E +++G++ ++IGH+N+G+ W +V +R + T FPC RWL DD
Sbjct: 1001 ECQNLGKLTT-VQIGHDNSGLYAKWLVEYVMVRNEIT----GHTYKFPCGRWLGKGMDDG 1055
Query: 314 KTIRELV 320
R LV
Sbjct: 1056 SLERILV 1062
Score = 39.3 bits (90), Expect = 0.021
Identities = 29/119 (24%), Positives = 50/119 (42%), Gaps = 12/119 (10%)
Query: 515 IIPYYVSVTTGKHKDAAT-DSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVA 573
+IPY++ + K + + +I + GE E + PR +V E
Sbjct: 953 LIPYHILIVPSKKLGGSMFTANPWICISGELGETQI---MQIPR--------NVLEMTFE 1001
Query: 574 GLDVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRV 632
++G + +++GHD + + WLVE + + G Y C WL K DG R+
Sbjct: 1002 CQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERI 1060
Score = 33.5 bits (75), Expect = 1.2
Identities = 25/107 (23%), Positives = 48/107 (44%), Gaps = 9/107 (8%)
Query: 645 VKVLYEMTVWTGDVVGGGT-DSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEIL 703
+ + Y + + +GG +N ++ + G G T+ MQ+ + TF E
Sbjct: 952 ILIPYHILIVPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEM------TF--ECQ 1003
Query: 704 DIAPFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQ 750
++ T ++I D G +W +E ++++N TG F G WL +
Sbjct: 1004 NLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGK 1050
Score = 33.5 bits (75), Expect = 1.2
Identities = 17/32 (53%), Positives = 19/32 (59%), Gaps = 3/32 (9%)
Query: 1 MNNEIT---YYFPCQRWLAVEEDDGQLSRELL 29
+ NEIT Y FPC RWL DDG L R L+
Sbjct: 1031 VRNEITGHTYKFPCGRWLGKGMDDGSLERILV 1062
>gi|4502057 arachidonate 5-lipoxygenase [Homo sapiens]
Length = 674
Score = 47.4 bits (111), Expect = 8e-05
Identities = 31/106 (29%), Positives = 58/106 (54%), Gaps = 6/106 (5%)
Query: 65 TFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLD 124
+++VT+ TG + AGTD ++++L G+ + LL K + FER +++ + V T+D
Sbjct: 3 SYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLL--DKPFYNDFERGAVDSYDV-TVD 59
Query: 125 --LGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWL 168
LG++ VR+ W++ ++ + P G + FPC RW+
Sbjct: 60 EELGEIQLVRIEKRKYWLNDDWYLKYITLKTPH-GDYIEFPCYRWI 104
Score = 46.6 bits (109), Expect = 1e-04
Identities = 30/105 (28%), Positives = 53/105 (50%), Gaps = 4/105 (3%)
Query: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEA-AD 409
Y+V + TG+ AGTD +Y+++ G G + + L K N FERG D++ + +
Sbjct: 4 YTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKP--FYNDFERGAVDSYDVTVDEE 61
Query: 410 LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLS 454
LG I +++ DWY++ + + + D F C RW++
Sbjct: 62 LGEIQLVRIEKRKYWLNDDWYLKYITL-KTPHGDYIEFPCYRWIT 105
Score = 43.9 bits (102), Expect = 9e-04
Identities = 32/114 (28%), Positives = 52/114 (45%), Gaps = 5/114 (4%)
Query: 775 SYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLS 834
SYTV V T AGTD +++ + G G S L + +N FER D+++
Sbjct: 3 SYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPF-YNDFERGAVDSYDVTVDEE 61
Query: 835 LGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTV 888
LG + +R+ + W+L Y+ +K + F C W++ GD + V
Sbjct: 62 LGEIQLVRIEKRKYWLNDDWYLKYITLK-TPHGDYIEFPCYRWIT---GDVEVV 111
Score = 42.0 bits (97), Expect = 0.003
Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 17/114 (14%)
Query: 197 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQF---FERKSASRFIV 253
Y +T+ T + AGTD I++ + G A C+++ L K F FER + + V
Sbjct: 4 YTVTVATGSQWFAGTDDYIYLSLVG-SAGCSEKHLL------DKPFYNDFERGAVDSYDV 56
Query: 254 EL-EDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWL 306
+ E++GEI + +RI +N W+ ++ ++ P D E FPC RW+
Sbjct: 57 TVDEELGEI-QLVRIEKRKYWLNDDWYLKYITLK--TPHGDYIE---FPCYRWI 104
Score = 38.9 bits (89), Expect = 0.027
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 3/103 (2%)
Query: 649 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKAR-FEREQNDTFIMEI-LDIA 706
Y +TV TG GTD I+++L G G +E+ LDK FER D++ + + ++
Sbjct: 4 YTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELG 63
Query: 707 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 749
+RI +W+L+ I LK + GD F W++
Sbjct: 64 EIQLVRIEKRKYWLNDDWYLKYITLKTPH-GDYIEFPCYRWIT 105
Score = 37.7 bits (86), Expect = 0.061
Identities = 19/51 (37%), Positives = 30/51 (58%)
Query: 1045 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRF 1095
Y V V TG + AGTD +++++ G+ G + K L + N FERG+ D +
Sbjct: 4 YTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSY 54
Score = 30.4 bits (67), Expect = 9.8
Identities = 28/107 (26%), Positives = 45/107 (42%), Gaps = 4/107 (3%)
Query: 518 YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYV-AGLD 576
Y V+V TG A TD ++ L+G K + LD P F RG+V+ + V +
Sbjct: 4 YTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHL-LDKP-FYNDFERGAVDSYDVTVDEE 61
Query: 577 VGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKD 623
+G I+ + + W ++ + L P G C W+ D
Sbjct: 62 LGEIQLVRIEKRKYWLNDDWYLKYITLKTP-HGDYIEFPCYRWITGD 107
>gi|4502053 arachidonate 12-lipoxygenase, 12R type [Homo sapiens]
Length = 701
Score = 43.9 bits (102), Expect = 9e-04
Identities = 30/107 (28%), Positives = 56/107 (52%), Gaps = 7/107 (6%)
Query: 65 TFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVE-TL 123
T+ V + TG +GT ++ +T+ GTQ ++ LL + F ++ +TV+
Sbjct: 3 TYKVRVATGTDLLSGTRDSISLTIVGTQGESHKQLLNHFGRD---FATGAVGQYTVQCPQ 59
Query: 124 DLGDLWKVRLGHDNTGKAP--GWFVDWVEVDAPSLGKCMTFPCGRWL 168
DLG+L +RL + P W+ ++V++ AP+ G+ FP +W+
Sbjct: 60 DLGELIIIRLHKERYAFFPKDPWYCNYVQICAPN-GRIYHFPAYQWM 105
Score = 32.0 bits (71), Expect = 3.4
Identities = 32/125 (25%), Positives = 48/125 (38%), Gaps = 13/125 (10%)
Query: 775 SYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLS 834
+Y V V T L +GT ++ + I G G+S L F +
Sbjct: 3 TYKVRVATGTDLLSGTRDSISLTIVGTQGESHKQLLNHFG--RDFATGAVGQYTVQCPQD 60
Query: 835 LGHLCKLRVWHDNKGIFP--GWHLSYVDV-KDNSRDETFHFQCDCW------LSKSEGDG 885
LG L +R+ + FP W+ +YV + N R +HF W L+ E G
Sbjct: 61 LGELIIIRLHKERYAFFPKDPWYCNYVQICAPNGR--IYHFPAYQWMDGYETLALREATG 118
Query: 886 QTVRD 890
+T D
Sbjct: 119 KTTAD 123
>gi|40316937 arachidonate 15-lipoxygenase [Homo sapiens]
Length = 662
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/106 (24%), Positives = 46/106 (43%), Gaps = 6/106 (5%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
+ + + TG AG++ V + L G + + + + + +++ E L
Sbjct: 4 YRIRVSTGASLYAGSNNQVQLWLVGQHGEAAL----GKRLWPARGKETELKVEVPEYL-- 57
Query: 126 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKN 171
G L V+L + K WF +W+ V P G + FPC RW+ N
Sbjct: 58 GPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGN 103
Score = 32.3 bits (72), Expect = 2.6
Identities = 33/119 (27%), Positives = 51/119 (42%), Gaps = 14/119 (11%)
Query: 350 LYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAAD 409
LY +++ TG AG++ +V + + +G GE LGK RG +E +
Sbjct: 3 LYRIRVSTGASLYAGSNNQVQLWL---VGQHGEAALGKRLWPA----RGKETELKVEVPE 55
Query: 410 -LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRW------LSLKKEDGR 461
LG + +KLR + W+ + + DE F C RW LSL + GR
Sbjct: 56 YLGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGR 114
Score = 31.6 bits (70), Expect = 4.4
Identities = 29/115 (25%), Positives = 51/115 (44%), Gaps = 13/115 (11%)
Query: 518 YYVSVTTGKHKDAATDSRAFIFLIGEDDERS--KRIWLDYPRGKRGFSRGSVEEFYVAGL 575
Y + V+TG A ++++ ++L+G+ E + KR+W RGK + V E+ L
Sbjct: 4 YRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLW--PARGKETELKVEVPEYLGPLL 61
Query: 576 DVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITS 630
V + K+ L D W + + P G + C W+ G+G+ S
Sbjct: 62 FVKLRKRHLLKDD------AWFCNWISVQGPGAGDEVRFPCYRWV---EGNGVLS 107
>gi|154426292 arachidonate 12-lipoxygenase [Homo sapiens]
Length = 663
Score = 42.0 bits (97), Expect = 0.003
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 8/104 (7%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTL-LKSSKTNSDKFERDSIEIFTVETLD 124
+ + + TG +G+ V + L GT+ + + L L+ ++ ++F+ D E D
Sbjct: 4 YRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAE-------D 56
Query: 125 LGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWL 168
LG L VRL + WF D + V P + FPC RW+
Sbjct: 57 LGLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWV 100
>gi|182765464 arachidonate lipoxygenase 3 [Homo sapiens]
Length = 711
Score = 37.0 bits (84), Expect = 0.10
Identities = 30/110 (27%), Positives = 50/110 (45%), Gaps = 15/110 (13%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERD----SIEIFTVE 121
+ + + TG AGT N+ +TL GT + S K D+ RD S++ + V
Sbjct: 4 YRLCVTTGPYLRAGTLDNISVTLVGTCGE-------SPKQRLDRMGRDFAPGSVQKYKVR 56
Query: 122 -TLDLGDLWKVRLGHDNTG--KAPGWFVDWVEVDAPSLGKCMTFPCGRWL 168
T +LG+L +R+ + + W+ + V P G FPC +W+
Sbjct: 57 CTAELGELLLLRVHKERYAFFRKDSWYCSRICVTEPD-GSVSHFPCYQWI 105
Score = 32.7 bits (73), Expect = 2.0
Identities = 27/105 (25%), Positives = 40/105 (38%), Gaps = 5/105 (4%)
Query: 776 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 835
Y + V T L AGT N+ + + G G+S L + F + + L
Sbjct: 4 YRLCVTTGPYLRAGTLDNISVTLVGTCGESPKQRLDRMG--RDFAPGSVQKYKVRCTAEL 61
Query: 836 GHLCKLRVWHDNKGIF--PGWHLSYVDVKDNSRDETFHFQCDCWL 878
G L LRV + F W+ S + V + HF C W+
Sbjct: 62 GELLLLRVHKERYAFFRKDSWYCSRICVTEPD-GSVSHFPCYQWI 105
Score = 32.0 bits (71), Expect = 3.4
Identities = 19/51 (37%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 1045 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRF 1095
Y + VTTG AGT N+ VT+ G G++ K+ L + R+ F GS ++
Sbjct: 4 YRLCVTTGPYLRAGTLDNISVTLVGTCGESPKQRLDRMGRD-FAPGSVQKY 53
>gi|85067503 arachidonate 15-lipoxygenase, second type isoform b
[Homo sapiens]
Length = 602
Score = 31.2 bits (69), Expect = 5.7
Identities = 28/115 (24%), Positives = 47/115 (40%), Gaps = 20/115 (17%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
F V + TG AGT V +++ GT+ ++ L + + ++ E D+
Sbjct: 4 FRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPE--DV 61
Query: 126 GDLWKVRLGHDNTGKAP------------GWFVDWVEVDAPSLGKCMTFPCGRWL 168
G + +R+ KAP WF W ++ P G + FPC +WL
Sbjct: 62 GRVLLLRV-----HKAPPVLPLLGPLAPDAWFCRWFQL-TPPRGGHLLFPCYQWL 110
>gi|85067499 arachidonate 15-lipoxygenase, second type isoform a
[Homo sapiens]
Length = 647
Score = 31.2 bits (69), Expect = 5.7
Identities = 28/115 (24%), Positives = 47/115 (40%), Gaps = 20/115 (17%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
F V + TG AGT V +++ GT+ ++ L + + ++ E D+
Sbjct: 4 FRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPE--DV 61
Query: 126 GDLWKVRLGHDNTGKAP------------GWFVDWVEVDAPSLGKCMTFPCGRWL 168
G + +R+ KAP WF W ++ P G + FPC +WL
Sbjct: 62 GRVLLLRV-----HKAPPVLPLLGPLAPDAWFCRWFQL-TPPRGGHLLFPCYQWL 110
>gi|85067501 arachidonate 15-lipoxygenase, second type isoform d
[Homo sapiens]
Length = 676
Score = 31.2 bits (69), Expect = 5.7
Identities = 28/115 (24%), Positives = 47/115 (40%), Gaps = 20/115 (17%)
Query: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
F V + TG AGT V +++ GT+ ++ L + + ++ E D+
Sbjct: 4 FRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPE--DV 61
Query: 126 GDLWKVRLGHDNTGKAP------------GWFVDWVEVDAPSLGKCMTFPCGRWL 168
G + +R+ KAP WF W ++ P G + FPC +WL
Sbjct: 62 GRVLLLRV-----HKAPPVLPLLGPLAPDAWFCRWFQL-TPPRGGHLLFPCYQWL 110
>gi|169218320 PREDICTED: similar to BCL2-associated transcription
factor 1 isoform 2 [Homo sapiens]
Length = 869
Score = 30.8 bits (68), Expect = 7.5
Identities = 22/87 (25%), Positives = 35/87 (40%), Gaps = 3/87 (3%)
Query: 59 QKDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERD---SI 115
+ S + S K+ V K G+ G + KS + D FE D SI
Sbjct: 138 RSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESI 197
Query: 116 EIFTVETLDLGDLWKVRLGHDNTGKAP 142
+ F + GD+W +DN+ ++P
Sbjct: 198 DEFNKSSATSGDIWPGLSAYDNSPRSP 224
>gi|117938254 BCL2-associated transcription factor 1 isoform 3 [Homo
sapiens]
Length = 747
Score = 30.8 bits (68), Expect = 7.5
Identities = 22/87 (25%), Positives = 35/87 (40%), Gaps = 3/87 (3%)
Query: 59 QKDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERD---SI 115
+ S + S K+ V K G+ G + KS + D FE D SI
Sbjct: 140 RSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESI 199
Query: 116 EIFTVETLDLGDLWKVRLGHDNTGKAP 142
+ F + GD+W +DN+ ++P
Sbjct: 200 DEFNKSSATSGDIWPGLSAYDNSPRSP 226
>gi|117938251 BCL2-associated transcription factor 1 isoform 2 [Homo
sapiens]
Length = 869
Score = 30.8 bits (68), Expect = 7.5
Identities = 22/87 (25%), Positives = 35/87 (40%), Gaps = 3/87 (3%)
Query: 59 QKDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERD---SI 115
+ S + S K+ V K G+ G + KS + D FE D SI
Sbjct: 138 RSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESI 197
Query: 116 EIFTVETLDLGDLWKVRLGHDNTGKAP 142
+ F + GD+W +DN+ ++P
Sbjct: 198 DEFNKSSATSGDIWPGLSAYDNSPRSP 224
>gi|7661958 BCL2-associated transcription factor 1 isoform 1 [Homo
sapiens]
Length = 920
Score = 30.8 bits (68), Expect = 7.5
Identities = 22/87 (25%), Positives = 35/87 (40%), Gaps = 3/87 (3%)
Query: 59 QKDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERD---SI 115
+ S + S K+ V K G+ G + KS + D FE D SI
Sbjct: 140 RSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESI 199
Query: 116 EIFTVETLDLGDLWKVRLGHDNTGKAP 142
+ F + GD+W +DN+ ++P
Sbjct: 200 DEFNKSSATSGDIWPGLSAYDNSPRSP 226
>gi|118918395 fibronectin type III domain containing 3A isoform 1
[Homo sapiens]
Length = 1198
Score = 30.4 bits (67), Expect = 9.8
Identities = 23/86 (26%), Positives = 38/86 (44%), Gaps = 12/86 (13%)
Query: 298 LTFPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVL------- 350
LT+ L E D+ ++ EL Y++ KDG + VY V E +I L
Sbjct: 284 LTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVY--VGEETNITLNDLKPAM 341
Query: 351 ---YSVQIFTGNIPGAGTDAKVYITI 373
VQ +I G ++A+++ T+
Sbjct: 342 DYHAKVQAEYNSIKGTPSEAEIFTTL 367
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,690,675
Number of Sequences: 37866
Number of extensions: 1956879
Number of successful extensions: 4089
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 3393
Number of HSP's gapped (non-prelim): 274
length of query: 1114
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1001
effective length of database: 13,968,660
effective search space: 13982628660
effective search space used: 13982628660
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.