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Search of human proteins with 224177493
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224177493 nuclear receptor subfamily 1, group D, member 2
isoform 2 [Homo sapiens]
(504 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224177493 nuclear receptor subfamily 1, group D, member 2 iso... 1028 0.0
gi|224177491 nuclear receptor subfamily 1, group D, member 2 iso... 1028 0.0
gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Hom... 496 e-140
gi|19743905 RAR-related orphan receptor A isoform d [Homo sapiens] 143 4e-34
gi|4506577 RAR-related orphan receptor A isoform c [Homo sapiens] 143 4e-34
gi|19743901 RAR-related orphan receptor A isoform b [Homo sapiens] 143 4e-34
gi|19743903 RAR-related orphan receptor A isoform a [Homo sapiens] 143 4e-34
gi|19743907 RAR-related orphan receptor B [Homo sapiens] 138 1e-32
gi|29171750 peroxisome proliferative activated receptor, delta i... 134 1e-31
gi|5453940 peroxisome proliferative activated receptor, delta is... 134 1e-31
gi|116284373 peroxisome proliferative activated receptor gamma i... 132 7e-31
gi|20336229 peroxisome proliferative activated receptor gamma is... 132 7e-31
gi|116284368 peroxisome proliferative activated receptor gamma i... 132 7e-31
gi|116284370 peroxisome proliferative activated receptor gamma i... 132 7e-31
gi|48255918 RAR-related orphan receptor C isoform b [Homo sapiens] 130 4e-30
gi|19743909 RAR-related orphan receptor C isoform a [Homo sapiens] 130 4e-30
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 130 4e-30
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 130 4e-30
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 129 5e-30
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens] 129 5e-30
gi|50348666 peroxisome proliferative activated receptor, alpha [... 129 6e-30
gi|7549811 peroxisome proliferative activated receptor, alpha [H... 129 6e-30
gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens] 127 2e-29
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 127 2e-29
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 127 2e-29
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 127 2e-29
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 126 4e-29
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 126 4e-29
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 123 3e-28
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 111 2e-24
>gi|224177493 nuclear receptor subfamily 1, group D, member 2
isoform 2 [Homo sapiens]
Length = 504
Score = 1028 bits (2659), Expect = 0.0
Identities = 504/504 (100%), Positives = 504/504 (100%)
Query: 1 MKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNI 60
MKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNI
Sbjct: 1 MKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNI 60
Query: 61 QYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAM 120
QYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAM
Sbjct: 61 QYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAM 120
Query: 121 KTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIG 180
KTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIG
Sbjct: 121 KTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIG 180
Query: 181 MVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCSESQ 240
MVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCSESQ
Sbjct: 181 MVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCSESQ 240
Query: 241 QHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCN 300
QHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCN
Sbjct: 241 QHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCN 300
Query: 301 TGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQV 360
TGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQV
Sbjct: 301 TGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQV 360
Query: 361 NLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNA 420
NLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNA
Sbjct: 361 NLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNA 420
Query: 421 LQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLL 480
LQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLL
Sbjct: 421 LQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLL 480
Query: 481 LKLPDLRSLNNMHSEELLAFKVHP 504
LKLPDLRSLNNMHSEELLAFKVHP
Sbjct: 481 LKLPDLRSLNNMHSEELLAFKVHP 504
>gi|224177491 nuclear receptor subfamily 1, group D, member 2
isoform 1 [Homo sapiens]
Length = 579
Score = 1028 bits (2659), Expect = 0.0
Identities = 504/504 (100%), Positives = 504/504 (100%)
Query: 1 MKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNI 60
MKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNI
Sbjct: 76 MKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNI 135
Query: 61 QYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAM 120
QYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAM
Sbjct: 136 QYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAM 195
Query: 121 KTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIG 180
KTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIG
Sbjct: 196 KTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIG 255
Query: 181 MVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCSESQ 240
MVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCSESQ
Sbjct: 256 MVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCSESQ 315
Query: 241 QHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCN 300
QHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCN
Sbjct: 316 QHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCN 375
Query: 301 TGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQV 360
TGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQV
Sbjct: 376 TGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQV 435
Query: 361 NLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNA 420
NLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNA
Sbjct: 436 NLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNA 495
Query: 421 LQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLL 480
LQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLL
Sbjct: 496 LQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLL 555
Query: 481 LKLPDLRSLNNMHSEELLAFKVHP 504
LKLPDLRSLNNMHSEELLAFKVHP
Sbjct: 556 LKLPDLRSLNNMHSEELLAFKVHP 579
>gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Homo
sapiens]
Length = 614
Score = 496 bits (1276), Expect = e-140
Identities = 286/514 (55%), Positives = 345/514 (67%), Gaps = 29/514 (5%)
Query: 6 SSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKC 65
SS +KS S +TK +GMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYK+C
Sbjct: 110 SSRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRC 169
Query: 66 LKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMN 125
LKNENCSI+R+NRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRML EMQSAM + N
Sbjct: 170 LKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMN-LAN 228
Query: 126 SQFSGHLQNDTLVEHHEQTALPAQEQLRPKP---------QLEQENIKSSSPPSSDFAKE 176
+Q S +T H T P P P Q Q+ SP S + E
Sbjct: 229 NQLSSQCPLETSPTQHP-TPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRSP-SPEPTVE 286
Query: 177 EVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPC 236
+VI V RAH++ F Y ++ +S + P + + C + +
Sbjct: 287 DVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTL 346
Query: 237 SESQQH---LNG--QFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQN 291
+ +Q+H LNG Q +P G A H + SN+ R+C P ++
Sbjct: 347 A-AQRHNEALNGLRQAPSSYPPTWPPGPA-----HHSCHQSNSNGHRLC---PTHVYAAP 397
Query: 292 ENK---NSYLCNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRI 348
E K NS + L CPM+ P+ ++ EIWE+FSMSFTPAV+EVVEFAK I
Sbjct: 398 EGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHI 457
Query: 349 PGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLL 408
PGFRDLSQHDQV LLKAGTFEVLMVRFASLF+ K++TV FLS YS+ +L +MG GDLL
Sbjct: 458 PGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLL 517
Query: 409 NSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKN 468
++MF+FSEKLN+L L++EE+ LFTAVVLVSADRSG+EN SVE LQETL+RALR L++KN
Sbjct: 518 SAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKN 577
Query: 469 HPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 502
P E S FTKLLLKLPDLR+LNNMHSE+LL+F+V
Sbjct: 578 RPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFRV 611
>gi|19743905 RAR-related orphan receptor A isoform d [Homo sapiens]
Length = 468
Score = 143 bits (360), Expect = 4e-34
Identities = 77/182 (42%), Positives = 120/182 (65%), Gaps = 2/182 (1%)
Query: 320 HKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLF 379
+K +W+ ++ T A++ VVEFAKRI GF +L Q+DQ+ LLKAG+ EV+ +R F
Sbjct: 258 NKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAF 317
Query: 380 DAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSA 439
D++ TV F GK S D S+G D ++ +FEF + L ++ L+++E++LF+A VL+SA
Sbjct: 318 DSQNNTVYF-DGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSA 376
Query: 440 DRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLA 499
DRS ++ +E LQ+ + AL+ ++ KNH E I TKL+ K+ LR+L H+E+L+A
Sbjct: 377 DRSWLQEKVKIEKLQQKIQLALQHVLQKNH-REDGILTKLICKVSTLRALCGRHTEKLMA 435
Query: 500 FK 501
FK
Sbjct: 436 FK 437
Score = 124 bits (312), Expect = 2e-28
Identities = 59/109 (54%), Positives = 75/109 (68%), Gaps = 4/109 (3%)
Query: 25 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQC 84
++ CK+CGD +SG HYGV CEGCKGFFRRS Q N Y C + +NC I R +RNRCQ C
Sbjct: 15 IIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYS-CPRQKNCLIDRTSRNRCQHC 73
Query: 85 RFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQ 133
R +KCL+VGMSRDAV+FGR+ K+++ + E+Q K M Q H Q
Sbjct: 74 RLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQ---KHRMQQQQRDHQQ 119
>gi|4506577 RAR-related orphan receptor A isoform c [Homo sapiens]
Length = 548
Score = 143 bits (360), Expect = 4e-34
Identities = 77/182 (42%), Positives = 120/182 (65%), Gaps = 2/182 (1%)
Query: 320 HKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLF 379
+K +W+ ++ T A++ VVEFAKRI GF +L Q+DQ+ LLKAG+ EV+ +R F
Sbjct: 338 NKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAF 397
Query: 380 DAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSA 439
D++ TV F GK S D S+G D ++ +FEF + L ++ L+++E++LF+A VL+SA
Sbjct: 398 DSQNNTVYF-DGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSA 456
Query: 440 DRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLA 499
DRS ++ +E LQ+ + AL+ ++ KNH E I TKL+ K+ LR+L H+E+L+A
Sbjct: 457 DRSWLQEKVKIEKLQQKIQLALQHVLQKNH-REDGILTKLICKVSTLRALCGRHTEKLMA 515
Query: 500 FK 501
FK
Sbjct: 516 FK 517
Score = 124 bits (312), Expect = 2e-28
Identities = 59/109 (54%), Positives = 75/109 (68%), Gaps = 4/109 (3%)
Query: 25 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQC 84
++ CK+CGD +SG HYGV CEGCKGFFRRS Q N Y C + +NC I R +RNRCQ C
Sbjct: 95 IIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYS-CPRQKNCLIDRTSRNRCQHC 153
Query: 85 RFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQ 133
R +KCL+VGMSRDAV+FGR+ K+++ + E+Q K M Q H Q
Sbjct: 154 RLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQ---KHRMQQQQRDHQQ 199
>gi|19743901 RAR-related orphan receptor A isoform b [Homo sapiens]
Length = 556
Score = 143 bits (360), Expect = 4e-34
Identities = 77/182 (42%), Positives = 120/182 (65%), Gaps = 2/182 (1%)
Query: 320 HKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLF 379
+K +W+ ++ T A++ VVEFAKRI GF +L Q+DQ+ LLKAG+ EV+ +R F
Sbjct: 346 NKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAF 405
Query: 380 DAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSA 439
D++ TV F GK S D S+G D ++ +FEF + L ++ L+++E++LF+A VL+SA
Sbjct: 406 DSQNNTVYF-DGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSA 464
Query: 440 DRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLA 499
DRS ++ +E LQ+ + AL+ ++ KNH E I TKL+ K+ LR+L H+E+L+A
Sbjct: 465 DRSWLQEKVKIEKLQQKIQLALQHVLQKNH-REDGILTKLICKVSTLRALCGRHTEKLMA 523
Query: 500 FK 501
FK
Sbjct: 524 FK 525
Score = 124 bits (312), Expect = 2e-28
Identities = 59/109 (54%), Positives = 75/109 (68%), Gaps = 4/109 (3%)
Query: 25 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQC 84
++ CK+CGD +SG HYGV CEGCKGFFRRS Q N Y C + +NC I R +RNRCQ C
Sbjct: 103 IIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYS-CPRQKNCLIDRTSRNRCQHC 161
Query: 85 RFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQ 133
R +KCL+VGMSRDAV+FGR+ K+++ + E+Q K M Q H Q
Sbjct: 162 RLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQ---KHRMQQQQRDHQQ 207
>gi|19743903 RAR-related orphan receptor A isoform a [Homo sapiens]
Length = 523
Score = 143 bits (360), Expect = 4e-34
Identities = 77/182 (42%), Positives = 120/182 (65%), Gaps = 2/182 (1%)
Query: 320 HKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLF 379
+K +W+ ++ T A++ VVEFAKRI GF +L Q+DQ+ LLKAG+ EV+ +R F
Sbjct: 313 NKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAF 372
Query: 380 DAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSA 439
D++ TV F GK S D S+G D ++ +FEF + L ++ L+++E++LF+A VL+SA
Sbjct: 373 DSQNNTVYF-DGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSA 431
Query: 440 DRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLA 499
DRS ++ +E LQ+ + AL+ ++ KNH E I TKL+ K+ LR+L H+E+L+A
Sbjct: 432 DRSWLQEKVKIEKLQQKIQLALQHVLQKNH-REDGILTKLICKVSTLRALCGRHTEKLMA 490
Query: 500 FK 501
FK
Sbjct: 491 FK 492
Score = 124 bits (312), Expect = 2e-28
Identities = 59/109 (54%), Positives = 75/109 (68%), Gaps = 4/109 (3%)
Query: 25 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQC 84
++ CK+CGD +SG HYGV CEGCKGFFRRS Q N Y C + +NC I R +RNRCQ C
Sbjct: 70 IIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYS-CPRQKNCLIDRTSRNRCQHC 128
Query: 85 RFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQ 133
R +KCL+VGMSRDAV+FGR+ K+++ + E+Q K M Q H Q
Sbjct: 129 RLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQ---KHRMQQQQRDHQQ 174
>gi|19743907 RAR-related orphan receptor B [Homo sapiens]
Length = 459
Score = 138 bits (348), Expect = 1e-32
Identities = 74/185 (40%), Positives = 121/185 (65%), Gaps = 3/185 (1%)
Query: 321 KSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFD 380
KS +W++ ++ T A++ VVEFAKRI GF +L Q+DQ+ LLK+G EV++VR F+
Sbjct: 253 KSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFN 312
Query: 381 AKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSAD 440
TV F GK + ++G+ DL+N F+F++ L +LQL++EE++LF++ VL+S D
Sbjct: 313 PLNNTVLF-EGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPD 371
Query: 441 RSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAF 500
R+ + V+ LQE + AL+ +I KNH ++ ++ KL+ K+P + ++ N+H E+L F
Sbjct: 372 RAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETL-AKLIAKIPTITAVCNLHGEKLQVF 430
Query: 501 K-VHP 504
K HP
Sbjct: 431 KQSHP 435
Score = 125 bits (313), Expect = 1e-28
Identities = 66/170 (38%), Positives = 94/170 (55%), Gaps = 14/170 (8%)
Query: 25 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQC 84
V+ CK+CGD +SG HYGV CEGCKGFFRRS Q N Y C + NC I R NRNRCQ C
Sbjct: 7 VIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYS-CPRQRNCLIDRTNRNRCQHC 65
Query: 85 RFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ-------------FSGH 131
R +KCL++GMSRDAV+FGR+ K+++ + E+Q + + + +S
Sbjct: 66 RLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSS 125
Query: 132 LQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIGM 181
+ N ++E + A + P+ E S PS D + ++ G+
Sbjct: 126 ISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGI 175
>gi|29171750 peroxisome proliferative activated receptor, delta
isoform 2 [Homo sapiens]
Length = 361
Score = 134 bits (338), Expect = 1e-31
Identities = 59/113 (52%), Positives = 83/113 (73%), Gaps = 8/113 (7%)
Query: 28 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 87
C+VCGD ASGFHYGVHACEGCKGFFRR+I+ ++Y+KC +C I + NRN+CQ CRF+
Sbjct: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKC--ERSCKIQKKNRNKCQYCRFQ 131
Query: 88 KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ------FSGHLQN 134
KCL++GMS +A+RFGR+P+ EK++++ + + + N Q FS H+ N
Sbjct: 132 KCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYN 184
Score = 62.0 bits (149), Expect = 1e-09
Identities = 38/102 (37%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 338 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 397
V+E+ EFAK IP F L +DQV LLK G E + AS+ + V SG + +
Sbjct: 257 VRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSG-FVTRE 315
Query: 398 DLHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLV 437
L S+ D++ FEF+ K NAL+L D +++LF A +++
Sbjct: 316 FLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIIL 357
>gi|5453940 peroxisome proliferative activated receptor, delta
isoform 1 [Homo sapiens]
Length = 441
Score = 134 bits (338), Expect = 1e-31
Identities = 59/113 (52%), Positives = 83/113 (73%), Gaps = 8/113 (7%)
Query: 28 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 87
C+VCGD ASGFHYGVHACEGCKGFFRR+I+ ++Y+KC +C I + NRN+CQ CRF+
Sbjct: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKC--ERSCKIQKKNRNKCQYCRFQ 131
Query: 88 KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ------FSGHLQN 134
KCL++GMS +A+RFGR+P+ EK++++ + + + N Q FS H+ N
Sbjct: 132 KCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYN 184
Score = 112 bits (280), Expect = 8e-25
Identities = 65/166 (39%), Positives = 96/166 (57%), Gaps = 3/166 (1%)
Query: 338 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 397
V+E+ EFAK IP F L +DQV LLK G E + AS+ + V SG + +
Sbjct: 257 VRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGF-VTRE 315
Query: 398 DLHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQE 455
L S+ D++ FEF+ K NAL+L D +++LF A +++ DR G+ NV VEA+Q+
Sbjct: 316 FLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQD 375
Query: 456 TLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFK 501
T++RAL + NHP+ +F KLL K+ DLR L H++ + K
Sbjct: 376 TILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIK 421
>gi|116284373 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 132 bits (332), Expect = 7e-31
Identities = 57/95 (60%), Positives = 77/95 (81%), Gaps = 2/95 (2%)
Query: 24 MVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQ 83
M + C+VCGD ASGFHYGVHACEGCKGFFRR+I+ + Y +C + NC I + +RN+CQ
Sbjct: 107 MAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC--DLNCRIHKKSRNKCQY 164
Query: 84 CRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQS 118
CRF+KCL+VGMS +A+RFGR+P+ EK+++L E+ S
Sbjct: 165 CRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISS 199
Score = 117 bits (292), Expect = 3e-26
Identities = 65/168 (38%), Positives = 100/168 (59%), Gaps = 5/168 (2%)
Query: 337 AVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSV 396
AV+E+ E+AK IPGF +L +DQV LLK G E++ ASL + + V G+ +
Sbjct: 292 AVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN--KDGVLISEGQGFMT 349
Query: 397 DD-LHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEAL 453
+ L S+ GD + FEF+ K NAL+L D ++++F AV+++S DR G+ NV +E +
Sbjct: 350 REFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDI 409
Query: 454 QETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFK 501
Q+ L++AL + NHP + +F KLL K+ DLR + H + L K
Sbjct: 410 QDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK 457
>gi|20336229 peroxisome proliferative activated receptor gamma
isoform 2 [Homo sapiens]
Length = 505
Score = 132 bits (332), Expect = 7e-31
Identities = 57/95 (60%), Positives = 77/95 (81%), Gaps = 2/95 (2%)
Query: 24 MVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQ 83
M + C+VCGD ASGFHYGVHACEGCKGFFRR+I+ + Y +C + NC I + +RN+CQ
Sbjct: 135 MAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC--DLNCRIHKKSRNKCQY 192
Query: 84 CRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQS 118
CRF+KCL+VGMS +A+RFGR+P+ EK+++L E+ S
Sbjct: 193 CRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISS 227
Score = 117 bits (292), Expect = 3e-26
Identities = 65/168 (38%), Positives = 100/168 (59%), Gaps = 5/168 (2%)
Query: 337 AVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSV 396
AV+E+ E+AK IPGF +L +DQV LLK G E++ ASL + + V G+ +
Sbjct: 320 AVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN--KDGVLISEGQGFMT 377
Query: 397 DD-LHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEAL 453
+ L S+ GD + FEF+ K NAL+L D ++++F AV+++S DR G+ NV +E +
Sbjct: 378 REFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDI 437
Query: 454 QETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFK 501
Q+ L++AL + NHP + +F KLL K+ DLR + H + L K
Sbjct: 438 QDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK 485
>gi|116284368 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 132 bits (332), Expect = 7e-31
Identities = 57/95 (60%), Positives = 77/95 (81%), Gaps = 2/95 (2%)
Query: 24 MVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQ 83
M + C+VCGD ASGFHYGVHACEGCKGFFRR+I+ + Y +C + NC I + +RN+CQ
Sbjct: 107 MAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC--DLNCRIHKKSRNKCQY 164
Query: 84 CRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQS 118
CRF+KCL+VGMS +A+RFGR+P+ EK+++L E+ S
Sbjct: 165 CRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISS 199
Score = 117 bits (292), Expect = 3e-26
Identities = 65/168 (38%), Positives = 100/168 (59%), Gaps = 5/168 (2%)
Query: 337 AVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSV 396
AV+E+ E+AK IPGF +L +DQV LLK G E++ ASL + + V G+ +
Sbjct: 292 AVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN--KDGVLISEGQGFMT 349
Query: 397 DD-LHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEAL 453
+ L S+ GD + FEF+ K NAL+L D ++++F AV+++S DR G+ NV +E +
Sbjct: 350 REFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDI 409
Query: 454 QETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFK 501
Q+ L++AL + NHP + +F KLL K+ DLR + H + L K
Sbjct: 410 QDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK 457
>gi|116284370 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 132 bits (332), Expect = 7e-31
Identities = 57/95 (60%), Positives = 77/95 (81%), Gaps = 2/95 (2%)
Query: 24 MVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQ 83
M + C+VCGD ASGFHYGVHACEGCKGFFRR+I+ + Y +C + NC I + +RN+CQ
Sbjct: 107 MAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC--DLNCRIHKKSRNKCQY 164
Query: 84 CRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQS 118
CRF+KCL+VGMS +A+RFGR+P+ EK+++L E+ S
Sbjct: 165 CRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISS 199
Score = 117 bits (292), Expect = 3e-26
Identities = 65/168 (38%), Positives = 100/168 (59%), Gaps = 5/168 (2%)
Query: 337 AVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSV 396
AV+E+ E+AK IPGF +L +DQV LLK G E++ ASL + + V G+ +
Sbjct: 292 AVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN--KDGVLISEGQGFMT 349
Query: 397 DD-LHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEAL 453
+ L S+ GD + FEF+ K NAL+L D ++++F AV+++S DR G+ NV +E +
Sbjct: 350 REFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDI 409
Query: 454 QETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFK 501
Q+ L++AL + NHP + +F KLL K+ DLR + H + L K
Sbjct: 410 QDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK 457
>gi|48255918 RAR-related orphan receptor C isoform b [Homo sapiens]
Length = 497
Score = 130 bits (326), Expect = 4e-30
Identities = 78/185 (42%), Positives = 114/185 (61%), Gaps = 5/185 (2%)
Query: 321 KSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFD 380
KS E+WE + T A++ VVEFAKR+ GF +L Q+DQ+ LLKAG EV++VR ++
Sbjct: 290 KSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYN 349
Query: 381 AKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSAD 440
A RTV F GK ++ ++G +L++S+F+FS L+AL S++E++L+TA+VL++A
Sbjct: 350 ADNRTV-FFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAH 408
Query: 441 RSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAF 500
R G++ VE LQ L A + K H SI KL K LRSL + H E L F
Sbjct: 409 RPGLQEKRKVEQLQYNLELAFHHHLCKTH--RQSILAKLPPK-GKLRSLCSQHVERLQIF 465
Query: 501 K-VHP 504
+ +HP
Sbjct: 466 QHLHP 470
Score = 122 bits (306), Expect = 8e-28
Identities = 54/103 (52%), Positives = 73/103 (70%), Gaps = 1/103 (0%)
Query: 25 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQC 84
V+ CK+CGD +SG HYGV CEGCKGFFRRS + N Y C + +NC I R +RNRCQ C
Sbjct: 7 VIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYS-CTRQQNCPIDRTSRNRCQHC 65
Query: 85 RFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ 127
R +KCL++GMSRDAV+FGR+ K+++ + E+Q ++ Q
Sbjct: 66 RLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQ 108
>gi|19743909 RAR-related orphan receptor C isoform a [Homo sapiens]
Length = 518
Score = 130 bits (326), Expect = 4e-30
Identities = 78/185 (42%), Positives = 114/185 (61%), Gaps = 5/185 (2%)
Query: 321 KSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFD 380
KS E+WE + T A++ VVEFAKR+ GF +L Q+DQ+ LLKAG EV++VR ++
Sbjct: 311 KSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYN 370
Query: 381 AKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSAD 440
A RTV F GK ++ ++G +L++S+F+FS L+AL S++E++L+TA+VL++A
Sbjct: 371 ADNRTV-FFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAH 429
Query: 441 RSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAF 500
R G++ VE LQ L A + K H SI KL K LRSL + H E L F
Sbjct: 430 RPGLQEKRKVEQLQYNLELAFHHHLCKTH--RQSILAKLPPK-GKLRSLCSQHVERLQIF 486
Query: 501 K-VHP 504
+ +HP
Sbjct: 487 QHLHP 491
Score = 122 bits (306), Expect = 8e-28
Identities = 54/103 (52%), Positives = 73/103 (70%), Gaps = 1/103 (0%)
Query: 25 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQC 84
V+ CK+CGD +SG HYGV CEGCKGFFRRS + N Y C + +NC I R +RNRCQ C
Sbjct: 28 VIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYS-CTRQQNCPIDRTSRNRCQHC 86
Query: 85 RFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ 127
R +KCL++GMSRDAV+FGR+ K+++ + E+Q ++ Q
Sbjct: 87 RLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQ 129
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 130 bits (326), Expect = 4e-30
Identities = 68/198 (34%), Positives = 120/198 (60%), Gaps = 5/198 (2%)
Query: 308 VCPMSKSPYVDPH--KSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKA 365
V P +P DPH ++ + + F+ +V+E+V+FAK++PGF LS+ DQ+ LLK
Sbjct: 190 VTPWPMAP--DPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKT 247
Query: 366 GTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAG-DLLNSMFEFSEKLNALQLS 424
EV+++ + ++ ++TFL Y+ +D G + +N +FEFS +N LQL+
Sbjct: 248 SAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLN 307
Query: 425 DEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLP 484
D E +L A+ + SADR +++ VE LQ T + AL + +HP++ +F ++L+KL
Sbjct: 308 DAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLV 367
Query: 485 DLRSLNNMHSEELLAFKV 502
LR+L+++HSE++ A ++
Sbjct: 368 SLRTLSSVHSEQVFALRL 385
Score = 85.1 bits (209), Expect = 1e-16
Identities = 39/91 (42%), Positives = 56/91 (61%), Gaps = 7/91 (7%)
Query: 27 LCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRF 86
LC VCGD ASGFHY V +CEGCKGFFRRS+ + Y C +C + R +CQ+CR
Sbjct: 52 LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHY-ICHSGGHCPMDTYMRRKCQECRL 110
Query: 87 KKCLSVGM------SRDAVRFGRIPKREKQR 111
+KC GM S + +R ++ ++E+++
Sbjct: 111 RKCRQAGMREECVLSEEQIRLKKLKRQEEEQ 141
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 130 bits (326), Expect = 4e-30
Identities = 68/198 (34%), Positives = 120/198 (60%), Gaps = 5/198 (2%)
Query: 308 VCPMSKSPYVDPH--KSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKA 365
V P +P DPH ++ + + F+ +V+E+V+FAK++PGF LS+ DQ+ LLK
Sbjct: 235 VTPWPMAP--DPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKT 292
Query: 366 GTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAG-DLLNSMFEFSEKLNALQLS 424
EV+++ + ++ ++TFL Y+ +D G + +N +FEFS +N LQL+
Sbjct: 293 SAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLN 352
Query: 425 DEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLP 484
D E +L A+ + SADR +++ VE LQ T + AL + +HP++ +F ++L+KL
Sbjct: 353 DAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLV 412
Query: 485 DLRSLNNMHSEELLAFKV 502
LR+L+++HSE++ A ++
Sbjct: 413 SLRTLSSVHSEQVFALRL 430
Score = 85.1 bits (209), Expect = 1e-16
Identities = 39/91 (42%), Positives = 56/91 (61%), Gaps = 7/91 (7%)
Query: 27 LCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRF 86
LC VCGD ASGFHY V +CEGCKGFFRRS+ + Y C +C + R +CQ+CR
Sbjct: 97 LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHY-ICHSGGHCPMDTYMRRKCQECRL 155
Query: 87 KKCLSVGM------SRDAVRFGRIPKREKQR 111
+KC GM S + +R ++ ++E+++
Sbjct: 156 RKCRQAGMREECVLSEEQIRLKKLKRQEEEQ 186
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 129 bits (325), Expect = 5e-30
Identities = 62/177 (35%), Positives = 108/177 (61%)
Query: 326 IWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERT 385
+W++FS T + ++VEFAKR+PGF L+ DQ+ LLKA ++L++R + + ++ T
Sbjct: 217 LWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDT 276
Query: 386 VTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIE 445
+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +E
Sbjct: 277 MTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLE 336
Query: 446 NVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 502
V+ LQE L+ AL+ I K P++ +F K+L+K+ DLRS++ +E ++ K+
Sbjct: 337 EPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKM 393
Score = 105 bits (262), Expect = 1e-22
Identities = 47/82 (57%), Positives = 63/82 (76%), Gaps = 1/82 (1%)
Query: 28 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 87
C VC D +SG+HYGV ACEGCKGFFRRSIQ+N+ Y C +++NC I ++ RNRCQ CR +
Sbjct: 81 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIY-TCHRDKNCVINKVTRNRCQYCRLQ 139
Query: 88 KCLSVGMSRDAVRFGRIPKREK 109
KC VGMS+++VR R K+++
Sbjct: 140 KCFEVGMSKESVRNDRNKKKKE 161
>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
Length = 336
Score = 129 bits (325), Expect = 5e-30
Identities = 62/177 (35%), Positives = 108/177 (61%)
Query: 326 IWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERT 385
+W++FS T + ++VEFAKR+PGF L+ DQ+ LLKA ++L++R + + ++ T
Sbjct: 105 LWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDT 164
Query: 386 VTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIE 445
+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +E
Sbjct: 165 MTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLE 224
Query: 446 NVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 502
V+ LQE L+ AL+ I K P++ +F K+L+K+ DLRS++ +E ++ K+
Sbjct: 225 EPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKM 281
Score = 52.8 bits (125), Expect = 7e-07
Identities = 21/45 (46%), Positives = 33/45 (73%)
Query: 65 CLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREK 109
C +++NC I ++ RNRCQ CR +KC VGMS+++VR R K+++
Sbjct: 5 CHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKE 49
>gi|50348666 peroxisome proliferative activated receptor, alpha
[Homo sapiens]
Length = 468
Score = 129 bits (324), Expect = 6e-30
Identities = 55/100 (55%), Positives = 76/100 (76%), Gaps = 2/100 (2%)
Query: 28 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 87
C++CGD ASG+HYGVHACEGCKGFFRR+I+ + Y KC + +C I + NRN+CQ CRF
Sbjct: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKC--DRSCKIQKKNRNKCQYCRFH 159
Query: 88 KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ 127
KCLSVGMS +A+RFGR+P+ EK ++ E+ + + +S+
Sbjct: 160 KCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSE 199
Score = 111 bits (277), Expect = 2e-24
Identities = 60/160 (37%), Positives = 94/160 (58%), Gaps = 3/160 (1%)
Query: 338 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 397
V E+ EFAK IPGF +L +DQV LLK G +E + +S+ + V + +G + +
Sbjct: 284 VTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF-ITRE 342
Query: 398 DLHSMGAG--DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQE 455
L S+ D++ F+F+ K NAL+L D ++SLF A ++ DR G+ NV +E +QE
Sbjct: 343 FLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQE 402
Query: 456 TLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSE 495
++ LR + NHP++ +F KLL K+ DLR L H++
Sbjct: 403 GIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQ 442
>gi|7549811 peroxisome proliferative activated receptor, alpha [Homo
sapiens]
Length = 468
Score = 129 bits (324), Expect = 6e-30
Identities = 55/100 (55%), Positives = 76/100 (76%), Gaps = 2/100 (2%)
Query: 28 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 87
C++CGD ASG+HYGVHACEGCKGFFRR+I+ + Y KC + +C I + NRN+CQ CRF
Sbjct: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKC--DRSCKIQKKNRNKCQYCRFH 159
Query: 88 KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ 127
KCLSVGMS +A+RFGR+P+ EK ++ E+ + + +S+
Sbjct: 160 KCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSE 199
Score = 111 bits (277), Expect = 2e-24
Identities = 60/160 (37%), Positives = 94/160 (58%), Gaps = 3/160 (1%)
Query: 338 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 397
V E+ EFAK IPGF +L +DQV LLK G +E + +S+ + V + +G + +
Sbjct: 284 VTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF-ITRE 342
Query: 398 DLHSMGAG--DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQE 455
L S+ D++ F+F+ K NAL+L D ++SLF A ++ DR G+ NV +E +QE
Sbjct: 343 FLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQE 402
Query: 456 TLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSE 495
++ LR + NHP++ +F KLL K+ DLR L H++
Sbjct: 403 GIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQ 442
>gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens]
Length = 365
Score = 127 bits (319), Expect = 2e-29
Identities = 60/178 (33%), Positives = 108/178 (60%)
Query: 325 EIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKER 384
++W++FS T + + VEFAK++PGF L+ DQ+ LLKA ++L++R + + ++
Sbjct: 126 DLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQD 185
Query: 385 TVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGI 444
T+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +
Sbjct: 186 TMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDL 245
Query: 445 ENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 502
E + V+ LQE L+ AL+ + K P+ +F K+L+K+ DLRS++ +E ++ K+
Sbjct: 246 EQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKM 303
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 127 bits (319), Expect = 2e-29
Identities = 60/178 (33%), Positives = 108/178 (60%)
Query: 325 EIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKER 384
++W++FS T + + VEFAK++PGF L+ DQ+ LLKA ++L++R + + ++
Sbjct: 223 DLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQD 282
Query: 385 TVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGI 444
T+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +
Sbjct: 283 TMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDL 342
Query: 445 ENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 502
E + V+ LQE L+ AL+ + K P+ +F K+L+K+ DLRS++ +E ++ K+
Sbjct: 343 EQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKM 400
Score = 106 bits (265), Expect = 4e-23
Identities = 51/109 (46%), Positives = 72/109 (66%), Gaps = 1/109 (0%)
Query: 1 MKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNI 60
++T SS+ + S + C VC D +SG+HYGV ACEGCKGFFRRSIQ+N+
Sbjct: 61 IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 120
Query: 61 QYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREK 109
Y C +++NC I ++ RNRCQ CR +KC VGMS+++VR R K+++
Sbjct: 121 VY-TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKE 168
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 127 bits (319), Expect = 2e-29
Identities = 60/178 (33%), Positives = 108/178 (60%)
Query: 325 EIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKER 384
++W++FS T + + VEFAK++PGF L+ DQ+ LLKA ++L++R + + ++
Sbjct: 218 DLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQD 277
Query: 385 TVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGI 444
T+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +
Sbjct: 278 TMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDL 337
Query: 445 ENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 502
E + V+ LQE L+ AL+ + K P+ +F K+L+K+ DLRS++ +E ++ K+
Sbjct: 338 EQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKM 395
Score = 106 bits (265), Expect = 4e-23
Identities = 51/109 (46%), Positives = 72/109 (66%), Gaps = 1/109 (0%)
Query: 1 MKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNI 60
++T SS+ + S + C VC D +SG+HYGV ACEGCKGFFRRSIQ+N+
Sbjct: 56 IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 115
Query: 61 QYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREK 109
Y C +++NC I ++ RNRCQ CR +KC VGMS+++VR R K+++
Sbjct: 116 VY-TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKE 163
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 127 bits (319), Expect = 2e-29
Identities = 60/178 (33%), Positives = 108/178 (60%)
Query: 325 EIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKER 384
++W++FS T + + VEFAK++PGF L+ DQ+ LLKA ++L++R + + ++
Sbjct: 223 DLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQD 282
Query: 385 TVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGI 444
T+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +
Sbjct: 283 TMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDL 342
Query: 445 ENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 502
E + V+ LQE L+ AL+ + K P+ +F K+L+K+ DLRS++ +E ++ K+
Sbjct: 343 EQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKM 400
Score = 106 bits (265), Expect = 4e-23
Identities = 51/109 (46%), Positives = 72/109 (66%), Gaps = 1/109 (0%)
Query: 1 MKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNI 60
++T SS+ + S + C VC D +SG+HYGV ACEGCKGFFRRSIQ+N+
Sbjct: 61 IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 120
Query: 61 QYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREK 109
Y C +++NC I ++ RNRCQ CR +KC VGMS+++VR R K+++
Sbjct: 121 VY-TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKE 168
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 126 bits (317), Expect = 4e-29
Identities = 61/177 (34%), Positives = 105/177 (59%)
Query: 326 IWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERT 385
+W++FS T + ++VEFAKR+PGF LS DQ+ LLKA ++LM+R + + ++ T
Sbjct: 215 LWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDT 274
Query: 386 VTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIE 445
+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +E
Sbjct: 275 MTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLE 334
Query: 446 NVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 502
V+ LQE L+ ALR + P++ +F ++L+K+ DLR ++ +E + K+
Sbjct: 335 EPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKM 391
Score = 106 bits (265), Expect = 4e-23
Identities = 47/82 (57%), Positives = 63/82 (76%), Gaps = 1/82 (1%)
Query: 28 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 87
C VC D +SG+HYGV +CEGCKGFFRRSIQ+N+ Y C +++NC I ++ RNRCQ CR +
Sbjct: 79 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVY-TCHRDKNCIINKVTRNRCQYCRLQ 137
Query: 88 KCLSVGMSRDAVRFGRIPKREK 109
KC VGMS++AVR R K+++
Sbjct: 138 KCFEVGMSKEAVRNDRNKKKKE 159
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 126 bits (317), Expect = 4e-29
Identities = 61/177 (34%), Positives = 105/177 (59%)
Query: 326 IWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERT 385
+W++FS T + ++VEFAKR+PGF LS DQ+ LLKA ++LM+R + + ++ T
Sbjct: 226 LWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDT 285
Query: 386 VTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIE 445
+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +E
Sbjct: 286 MTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLE 345
Query: 446 NVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 502
V+ LQE L+ ALR + P++ +F ++L+K+ DLR ++ +E + K+
Sbjct: 346 EPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKM 402
Score = 106 bits (265), Expect = 4e-23
Identities = 47/82 (57%), Positives = 63/82 (76%), Gaps = 1/82 (1%)
Query: 28 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 87
C VC D +SG+HYGV +CEGCKGFFRRSIQ+N+ Y C +++NC I ++ RNRCQ CR +
Sbjct: 90 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVY-TCHRDKNCIINKVTRNRCQYCRLQ 148
Query: 88 KCLSVGMSRDAVRFGRIPKREK 109
KC VGMS++AVR R K+++
Sbjct: 149 KCFEVGMSKEAVRNDRNKKKKE 170
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 123 bits (309), Expect = 3e-28
Identities = 62/167 (37%), Positives = 102/167 (61%), Gaps = 1/167 (0%)
Query: 337 AVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSV 396
+V+E+V+FAK++PGF L + DQ+ LLKA T E++++ A ++ + +TFL YS
Sbjct: 278 SVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSK 337
Query: 397 DDLHSMGAG-DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQE 455
DD H G + +N +FEFS + L L D E +L A+ + SADR ++ VEALQ+
Sbjct: 338 DDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQ 397
Query: 456 TLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 502
+ AL + P + F ++L+KL LR+L+++HSE++ A ++
Sbjct: 398 PYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRL 444
Score = 86.3 bits (212), Expect = 6e-17
Identities = 43/99 (43%), Positives = 58/99 (58%), Gaps = 7/99 (7%)
Query: 27 LCKVCGDVASGFHYGVHACEGCKGFFRRS-IQQNIQYKKCLKNENCSIMRMNRNRCQQCR 85
LC+VCGD ASGFHY V +CEGCKGFFRRS ++ + C C + R +CQQCR
Sbjct: 86 LCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCR 145
Query: 86 FKKCLSVGM------SRDAVRFGRIPKREKQRMLIEMQS 118
+KC GM S + +R +I K+++Q + QS
Sbjct: 146 LRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQS 184
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 111 bits (277), Expect = 2e-24
Identities = 68/202 (33%), Positives = 106/202 (52%), Gaps = 3/202 (1%)
Query: 304 RMHLVCPMSKSPYV---DPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQV 360
R L + +SP V D K E + EF+ TPA+ VV+FAK++P F +L DQ+
Sbjct: 189 RKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQI 248
Query: 361 NLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNA 420
LLK E++ +R A +D + T+T + L + G G + +++FE + L+A
Sbjct: 249 ILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSA 308
Query: 421 LQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLL 480
L D E++L AV+L+S DRSG+ V+ +E QE + A + N + KLL
Sbjct: 309 FNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLL 368
Query: 481 LKLPDLRSLNNMHSEELLAFKV 502
+K+ DLR + H+ L KV
Sbjct: 369 MKVTDLRMIGACHASRFLHMKV 390
Score = 93.2 bits (230), Expect = 5e-19
Identities = 45/89 (50%), Positives = 61/89 (68%), Gaps = 3/89 (3%)
Query: 28 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIM-RMNRNRCQQCRF 86
C VCGD A+G+HY CEGCKGFFRR+IQ+N+ K ++C ++ ++ RN+CQ CRF
Sbjct: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
Query: 87 KKCLSVGMSRDAVRFGRIPKREKQRMLIE 115
KKC++VGM+ D V KR +R LIE
Sbjct: 113 KKCIAVGMAMDLVLDD--SKRVAKRKLIE 139
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.131 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,770,780
Number of Sequences: 37866
Number of extensions: 844419
Number of successful extensions: 2893
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 127
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 2452
Number of HSP's gapped (non-prelim): 279
length of query: 504
length of database: 18,247,518
effective HSP length: 107
effective length of query: 397
effective length of database: 14,195,856
effective search space: 5635754832
effective search space used: 5635754832
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.