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Search of human proteins with 224177491
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224177491 nuclear receptor subfamily 1, group D, member 2
isoform 1 [Homo sapiens]
(579 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224177491 nuclear receptor subfamily 1, group D, member 2 iso... 1174 0.0
gi|224177493 nuclear receptor subfamily 1, group D, member 2 iso... 1028 0.0
gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Hom... 519 e-147
gi|19743905 RAR-related orphan receptor A isoform d [Homo sapiens] 143 5e-34
gi|4506577 RAR-related orphan receptor A isoform c [Homo sapiens] 143 5e-34
gi|19743901 RAR-related orphan receptor A isoform b [Homo sapiens] 143 5e-34
gi|19743903 RAR-related orphan receptor A isoform a [Homo sapiens] 143 5e-34
gi|19743907 RAR-related orphan receptor B [Homo sapiens] 138 1e-32
gi|29171750 peroxisome proliferative activated receptor, delta i... 134 2e-31
gi|5453940 peroxisome proliferative activated receptor, delta is... 134 2e-31
gi|116284373 peroxisome proliferative activated receptor gamma i... 132 9e-31
gi|20336229 peroxisome proliferative activated receptor gamma is... 132 9e-31
gi|116284368 peroxisome proliferative activated receptor gamma i... 132 9e-31
gi|116284370 peroxisome proliferative activated receptor gamma i... 132 9e-31
gi|48255918 RAR-related orphan receptor C isoform b [Homo sapiens] 130 4e-30
gi|19743909 RAR-related orphan receptor C isoform a [Homo sapiens] 130 4e-30
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 130 4e-30
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 130 4e-30
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 129 6e-30
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens] 129 6e-30
gi|50348666 peroxisome proliferative activated receptor, alpha [... 129 7e-30
gi|7549811 peroxisome proliferative activated receptor, alpha [H... 129 7e-30
gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens] 127 3e-29
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 127 3e-29
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 127 3e-29
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 127 3e-29
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 126 5e-29
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 126 5e-29
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 123 4e-28
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 111 2e-24
>gi|224177491 nuclear receptor subfamily 1, group D, member 2
isoform 1 [Homo sapiens]
Length = 579
Score = 1174 bits (3038), Expect = 0.0
Identities = 579/579 (100%), Positives = 579/579 (100%)
Query: 1 MEVNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDTNGNPKNGDL 60
MEVNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDTNGNPKNGDL
Sbjct: 1 MEVNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDTNGNPKNGDL 60
Query: 61 ANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHAC 120
ANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHAC
Sbjct: 61 ANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHAC 120
Query: 121 EGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIP 180
EGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIP
Sbjct: 121 EGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIP 180
Query: 181 KREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKS 240
KREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKS
Sbjct: 181 KREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKS 240
Query: 241 SSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDH 300
SSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDH
Sbjct: 241 SSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDH 300
Query: 301 CGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPI 360
CGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPI
Sbjct: 301 CGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPI 360
Query: 361 DGFSQNENKNSYLCNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFA 420
DGFSQNENKNSYLCNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFA
Sbjct: 361 DGFSQNENKNSYLCNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFA 420
Query: 421 KRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAG 480
KRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAG
Sbjct: 421 KRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAG 480
Query: 481 DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLI 540
DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLI
Sbjct: 481 DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLI 540
Query: 541 MKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP 579
MKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP
Sbjct: 541 MKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP 579
>gi|224177493 nuclear receptor subfamily 1, group D, member 2
isoform 2 [Homo sapiens]
Length = 504
Score = 1028 bits (2659), Expect = 0.0
Identities = 504/504 (100%), Positives = 504/504 (100%)
Query: 76 MKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNI 135
MKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNI
Sbjct: 1 MKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNI 60
Query: 136 QYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAM 195
QYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAM
Sbjct: 61 QYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAM 120
Query: 196 KTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIG 255
KTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIG
Sbjct: 121 KTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIG 180
Query: 256 MVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCSESQ 315
MVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCSESQ
Sbjct: 181 MVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCSESQ 240
Query: 316 QHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCN 375
QHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCN
Sbjct: 241 QHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCN 300
Query: 376 TGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQV 435
TGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQV
Sbjct: 301 TGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQV 360
Query: 436 NLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNA 495
NLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNA
Sbjct: 361 NLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNA 420
Query: 496 LQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLL 555
LQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLL
Sbjct: 421 LQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLL 480
Query: 556 LKLPDLRSLNNMHSEELLAFKVHP 579
LKLPDLRSLNNMHSEELLAFKVHP
Sbjct: 481 LKLPDLRSLNNMHSEELLAFKVHP 504
>gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Homo
sapiens]
Length = 614
Score = 519 bits (1337), Expect = e-147
Identities = 313/615 (50%), Positives = 382/615 (62%), Gaps = 53/615 (8%)
Query: 4 NAGGVIAYISSSSSA---SSPASCHSEGSENSFQSSSSSVPS-SPNSSNSDTNGNPKNGD 59
N GGVI YI SS S+ +SP S +S+ S SFQS + P+ P S +P
Sbjct: 9 NTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQGCPTYFPPSPTGSLTQDPAR-S 67
Query: 60 LANIEGILKNDRIDCSMKTSKSSA--------PGM-------------TKSHSGVTKFSG 98
+I L +D S +S SS+ PG +KS S +TK +G
Sbjct: 68 FGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKSTSNITKLNG 127
Query: 99 MVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQ 158
MVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYK+CLKNENCSI+R+NRNRCQQ
Sbjct: 128 MVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQ 187
Query: 159 CRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQ 218
CRFKKCLSVGMSRDAVRFGRIPKREKQRML EMQSAM + N+Q S +T H
Sbjct: 188 CRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAM-NLANNQLSSQCPLETSPTQH-P 245
Query: 219 TALPAQEQLRPKP---------QLEQENIKSSSPPSSDFAKEEVIGMVTRAHKDTFMYNQ 269
T P P P Q Q+ + PS + E+VI V RAH++ F Y
Sbjct: 246 TPGPMGPSPPPAPVPSPLVGFSQFPQQ-LTPPRSPSPEPTVEDVISQVARAHREIFTYAH 304
Query: 270 EQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSH--FPCSESQQHLNG--QFKGR 325
++ +S + P + + C + + + LNG Q
Sbjct: 305 DKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQAPSS 364
Query: 326 NIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENK---NSYLCNTGGRMHL 382
+P G A H + SN+ R+C P ++ E K NS + L
Sbjct: 365 YPPTWPPGPA-----HHSCHQSNSNGHRLC---PTHVYAAPEGKAPANSPRQGNSKNVLL 416
Query: 383 VCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGT 442
CPM+ P+ ++ EIWE+FSMSFTPAV+EVVEFAK IPGFRDLSQHDQV LLKAGT
Sbjct: 417 ACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGT 476
Query: 443 FEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEE 502
FEVLMVRFASLF+ K++TV FLS YS+ +L +MG GDLL++MF+FSEKLN+L L++EE
Sbjct: 477 FEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNSLALTEEE 536
Query: 503 MSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLR 562
+ LFTAVVLVSADRSG+EN SVE LQETL+RALR L++KN P E S FTKLLLKLPDLR
Sbjct: 537 LGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLETSRFTKLLLKLPDLR 596
Query: 563 SLNNMHSEELLAFKV 577
+LNNMHSE+LL+F+V
Sbjct: 597 TLNNMHSEKLLSFRV 611
>gi|19743905 RAR-related orphan receptor A isoform d [Homo sapiens]
Length = 468
Score = 143 bits (360), Expect = 5e-34
Identities = 77/182 (42%), Positives = 120/182 (65%), Gaps = 2/182 (1%)
Query: 395 HKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLF 454
+K +W+ ++ T A++ VVEFAKRI GF +L Q+DQ+ LLKAG+ EV+ +R F
Sbjct: 258 NKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAF 317
Query: 455 DAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSA 514
D++ TV F GK S D S+G D ++ +FEF + L ++ L+++E++LF+A VL+SA
Sbjct: 318 DSQNNTVYF-DGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSA 376
Query: 515 DRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLA 574
DRS ++ +E LQ+ + AL+ ++ KNH E I TKL+ K+ LR+L H+E+L+A
Sbjct: 377 DRSWLQEKVKIEKLQQKIQLALQHVLQKNH-REDGILTKLICKVSTLRALCGRHTEKLMA 435
Query: 575 FK 576
FK
Sbjct: 436 FK 437
Score = 124 bits (312), Expect = 2e-28
Identities = 59/109 (54%), Positives = 75/109 (68%), Gaps = 4/109 (3%)
Query: 100 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQC 159
++ CK+CGD +SG HYGV CEGCKGFFRRS Q N Y C + +NC I R +RNRCQ C
Sbjct: 15 IIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYS-CPRQKNCLIDRTSRNRCQHC 73
Query: 160 RFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQ 208
R +KCL+VGMSRDAV+FGR+ K+++ + E+Q K M Q H Q
Sbjct: 74 RLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQ---KHRMQQQQRDHQQ 119
>gi|4506577 RAR-related orphan receptor A isoform c [Homo sapiens]
Length = 548
Score = 143 bits (360), Expect = 5e-34
Identities = 77/182 (42%), Positives = 120/182 (65%), Gaps = 2/182 (1%)
Query: 395 HKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLF 454
+K +W+ ++ T A++ VVEFAKRI GF +L Q+DQ+ LLKAG+ EV+ +R F
Sbjct: 338 NKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAF 397
Query: 455 DAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSA 514
D++ TV F GK S D S+G D ++ +FEF + L ++ L+++E++LF+A VL+SA
Sbjct: 398 DSQNNTVYF-DGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSA 456
Query: 515 DRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLA 574
DRS ++ +E LQ+ + AL+ ++ KNH E I TKL+ K+ LR+L H+E+L+A
Sbjct: 457 DRSWLQEKVKIEKLQQKIQLALQHVLQKNH-REDGILTKLICKVSTLRALCGRHTEKLMA 515
Query: 575 FK 576
FK
Sbjct: 516 FK 517
Score = 124 bits (312), Expect = 2e-28
Identities = 59/109 (54%), Positives = 75/109 (68%), Gaps = 4/109 (3%)
Query: 100 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQC 159
++ CK+CGD +SG HYGV CEGCKGFFRRS Q N Y C + +NC I R +RNRCQ C
Sbjct: 95 IIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYS-CPRQKNCLIDRTSRNRCQHC 153
Query: 160 RFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQ 208
R +KCL+VGMSRDAV+FGR+ K+++ + E+Q K M Q H Q
Sbjct: 154 RLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQ---KHRMQQQQRDHQQ 199
>gi|19743901 RAR-related orphan receptor A isoform b [Homo sapiens]
Length = 556
Score = 143 bits (360), Expect = 5e-34
Identities = 77/182 (42%), Positives = 120/182 (65%), Gaps = 2/182 (1%)
Query: 395 HKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLF 454
+K +W+ ++ T A++ VVEFAKRI GF +L Q+DQ+ LLKAG+ EV+ +R F
Sbjct: 346 NKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAF 405
Query: 455 DAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSA 514
D++ TV F GK S D S+G D ++ +FEF + L ++ L+++E++LF+A VL+SA
Sbjct: 406 DSQNNTVYF-DGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSA 464
Query: 515 DRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLA 574
DRS ++ +E LQ+ + AL+ ++ KNH E I TKL+ K+ LR+L H+E+L+A
Sbjct: 465 DRSWLQEKVKIEKLQQKIQLALQHVLQKNH-REDGILTKLICKVSTLRALCGRHTEKLMA 523
Query: 575 FK 576
FK
Sbjct: 524 FK 525
Score = 124 bits (312), Expect = 2e-28
Identities = 59/109 (54%), Positives = 75/109 (68%), Gaps = 4/109 (3%)
Query: 100 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQC 159
++ CK+CGD +SG HYGV CEGCKGFFRRS Q N Y C + +NC I R +RNRCQ C
Sbjct: 103 IIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYS-CPRQKNCLIDRTSRNRCQHC 161
Query: 160 RFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQ 208
R +KCL+VGMSRDAV+FGR+ K+++ + E+Q K M Q H Q
Sbjct: 162 RLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQ---KHRMQQQQRDHQQ 207
>gi|19743903 RAR-related orphan receptor A isoform a [Homo sapiens]
Length = 523
Score = 143 bits (360), Expect = 5e-34
Identities = 77/182 (42%), Positives = 120/182 (65%), Gaps = 2/182 (1%)
Query: 395 HKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLF 454
+K +W+ ++ T A++ VVEFAKRI GF +L Q+DQ+ LLKAG+ EV+ +R F
Sbjct: 313 NKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAF 372
Query: 455 DAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSA 514
D++ TV F GK S D S+G D ++ +FEF + L ++ L+++E++LF+A VL+SA
Sbjct: 373 DSQNNTVYF-DGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSA 431
Query: 515 DRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLA 574
DRS ++ +E LQ+ + AL+ ++ KNH E I TKL+ K+ LR+L H+E+L+A
Sbjct: 432 DRSWLQEKVKIEKLQQKIQLALQHVLQKNH-REDGILTKLICKVSTLRALCGRHTEKLMA 490
Query: 575 FK 576
FK
Sbjct: 491 FK 492
Score = 129 bits (323), Expect = 1e-29
Identities = 71/180 (39%), Positives = 103/180 (57%), Gaps = 18/180 (10%)
Query: 39 SVPSSPNSSNSDTNGNPKNGDLANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSG 98
S P++P+ + S+ + + + E L + S + S+ AP +S+S ++
Sbjct: 3 SAPAAPDPAASEPGSSGADAAAGSRETPLNQE----SARKSEPPAPVRRQSYSSTSRGIS 58
Query: 99 M----------VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSI 148
+ ++ CK+CGD +SG HYGV CEGCKGFFRRS Q N Y C + +NC I
Sbjct: 59 VTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYS-CPRQKNCLI 117
Query: 149 MRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQ 208
R +RNRCQ CR +KCL+VGMSRDAV+FGR+ K+++ + E+Q K M Q H Q
Sbjct: 118 DRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQ---KHRMQQQQRDHQQ 174
>gi|19743907 RAR-related orphan receptor B [Homo sapiens]
Length = 459
Score = 138 bits (348), Expect = 1e-32
Identities = 74/185 (40%), Positives = 121/185 (65%), Gaps = 3/185 (1%)
Query: 396 KSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFD 455
KS +W++ ++ T A++ VVEFAKRI GF +L Q+DQ+ LLK+G EV++VR F+
Sbjct: 253 KSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFN 312
Query: 456 AKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSAD 515
TV F GK + ++G+ DL+N F+F++ L +LQL++EE++LF++ VL+S D
Sbjct: 313 PLNNTVLF-EGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPD 371
Query: 516 RSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAF 575
R+ + V+ LQE + AL+ +I KNH ++ ++ KL+ K+P + ++ N+H E+L F
Sbjct: 372 RAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETL-AKLIAKIPTITAVCNLHGEKLQVF 430
Query: 576 K-VHP 579
K HP
Sbjct: 431 KQSHP 435
Score = 125 bits (313), Expect = 1e-28
Identities = 66/170 (38%), Positives = 94/170 (55%), Gaps = 14/170 (8%)
Query: 100 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQC 159
V+ CK+CGD +SG HYGV CEGCKGFFRRS Q N Y C + NC I R NRNRCQ C
Sbjct: 7 VIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYS-CPRQRNCLIDRTNRNRCQHC 65
Query: 160 RFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ-------------FSGH 206
R +KCL++GMSRDAV+FGR+ K+++ + E+Q + + + +S
Sbjct: 66 RLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSS 125
Query: 207 LQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIGM 256
+ N ++E + A + P+ E S PS D + ++ G+
Sbjct: 126 ISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGI 175
>gi|29171750 peroxisome proliferative activated receptor, delta
isoform 2 [Homo sapiens]
Length = 361
Score = 134 bits (338), Expect = 2e-31
Identities = 59/113 (52%), Positives = 83/113 (73%), Gaps = 8/113 (7%)
Query: 103 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 162
C+VCGD ASGFHYGVHACEGCKGFFRR+I+ ++Y+KC +C I + NRN+CQ CRF+
Sbjct: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKC--ERSCKIQKKNRNKCQYCRFQ 131
Query: 163 KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ------FSGHLQN 209
KCL++GMS +A+RFGR+P+ EK++++ + + + N Q FS H+ N
Sbjct: 132 KCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYN 184
Score = 62.0 bits (149), Expect = 1e-09
Identities = 38/102 (37%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 413 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 472
V+E+ EFAK IP F L +DQV LLK G E + AS+ + V SG + +
Sbjct: 257 VRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSG-FVTRE 315
Query: 473 DLHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLV 512
L S+ D++ FEF+ K NAL+L D +++LF A +++
Sbjct: 316 FLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIIL 357
>gi|5453940 peroxisome proliferative activated receptor, delta
isoform 1 [Homo sapiens]
Length = 441
Score = 134 bits (338), Expect = 2e-31
Identities = 59/113 (52%), Positives = 83/113 (73%), Gaps = 8/113 (7%)
Query: 103 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 162
C+VCGD ASGFHYGVHACEGCKGFFRR+I+ ++Y+KC +C I + NRN+CQ CRF+
Sbjct: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKC--ERSCKIQKKNRNKCQYCRFQ 131
Query: 163 KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ------FSGHLQN 209
KCL++GMS +A+RFGR+P+ EK++++ + + + N Q FS H+ N
Sbjct: 132 KCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYN 184
Score = 112 bits (280), Expect = 9e-25
Identities = 65/166 (39%), Positives = 96/166 (57%), Gaps = 3/166 (1%)
Query: 413 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 472
V+E+ EFAK IP F L +DQV LLK G E + AS+ + V SG + +
Sbjct: 257 VRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGF-VTRE 315
Query: 473 DLHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQE 530
L S+ D++ FEF+ K NAL+L D +++LF A +++ DR G+ NV VEA+Q+
Sbjct: 316 FLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQD 375
Query: 531 TLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFK 576
T++RAL + NHP+ +F KLL K+ DLR L H++ + K
Sbjct: 376 TILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIK 421
>gi|116284373 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 132 bits (332), Expect = 9e-31
Identities = 57/95 (60%), Positives = 77/95 (81%), Gaps = 2/95 (2%)
Query: 99 MVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQ 158
M + C+VCGD ASGFHYGVHACEGCKGFFRR+I+ + Y +C + NC I + +RN+CQ
Sbjct: 107 MAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC--DLNCRIHKKSRNKCQY 164
Query: 159 CRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQS 193
CRF+KCL+VGMS +A+RFGR+P+ EK+++L E+ S
Sbjct: 165 CRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISS 199
Score = 117 bits (292), Expect = 4e-26
Identities = 65/168 (38%), Positives = 100/168 (59%), Gaps = 5/168 (2%)
Query: 412 AVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSV 471
AV+E+ E+AK IPGF +L +DQV LLK G E++ ASL + + V G+ +
Sbjct: 292 AVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN--KDGVLISEGQGFMT 349
Query: 472 DD-LHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEAL 528
+ L S+ GD + FEF+ K NAL+L D ++++F AV+++S DR G+ NV +E +
Sbjct: 350 REFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDI 409
Query: 529 QETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFK 576
Q+ L++AL + NHP + +F KLL K+ DLR + H + L K
Sbjct: 410 QDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK 457
>gi|20336229 peroxisome proliferative activated receptor gamma
isoform 2 [Homo sapiens]
Length = 505
Score = 132 bits (332), Expect = 9e-31
Identities = 57/95 (60%), Positives = 77/95 (81%), Gaps = 2/95 (2%)
Query: 99 MVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQ 158
M + C+VCGD ASGFHYGVHACEGCKGFFRR+I+ + Y +C + NC I + +RN+CQ
Sbjct: 135 MAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC--DLNCRIHKKSRNKCQY 192
Query: 159 CRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQS 193
CRF+KCL+VGMS +A+RFGR+P+ EK+++L E+ S
Sbjct: 193 CRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISS 227
Score = 117 bits (292), Expect = 4e-26
Identities = 65/168 (38%), Positives = 100/168 (59%), Gaps = 5/168 (2%)
Query: 412 AVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSV 471
AV+E+ E+AK IPGF +L +DQV LLK G E++ ASL + + V G+ +
Sbjct: 320 AVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN--KDGVLISEGQGFMT 377
Query: 472 DD-LHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEAL 528
+ L S+ GD + FEF+ K NAL+L D ++++F AV+++S DR G+ NV +E +
Sbjct: 378 REFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDI 437
Query: 529 QETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFK 576
Q+ L++AL + NHP + +F KLL K+ DLR + H + L K
Sbjct: 438 QDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK 485
>gi|116284368 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 132 bits (332), Expect = 9e-31
Identities = 57/95 (60%), Positives = 77/95 (81%), Gaps = 2/95 (2%)
Query: 99 MVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQ 158
M + C+VCGD ASGFHYGVHACEGCKGFFRR+I+ + Y +C + NC I + +RN+CQ
Sbjct: 107 MAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC--DLNCRIHKKSRNKCQY 164
Query: 159 CRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQS 193
CRF+KCL+VGMS +A+RFGR+P+ EK+++L E+ S
Sbjct: 165 CRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISS 199
Score = 117 bits (292), Expect = 4e-26
Identities = 65/168 (38%), Positives = 100/168 (59%), Gaps = 5/168 (2%)
Query: 412 AVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSV 471
AV+E+ E+AK IPGF +L +DQV LLK G E++ ASL + + V G+ +
Sbjct: 292 AVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN--KDGVLISEGQGFMT 349
Query: 472 DD-LHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEAL 528
+ L S+ GD + FEF+ K NAL+L D ++++F AV+++S DR G+ NV +E +
Sbjct: 350 REFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDI 409
Query: 529 QETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFK 576
Q+ L++AL + NHP + +F KLL K+ DLR + H + L K
Sbjct: 410 QDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK 457
>gi|116284370 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 132 bits (332), Expect = 9e-31
Identities = 57/95 (60%), Positives = 77/95 (81%), Gaps = 2/95 (2%)
Query: 99 MVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQ 158
M + C+VCGD ASGFHYGVHACEGCKGFFRR+I+ + Y +C + NC I + +RN+CQ
Sbjct: 107 MAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC--DLNCRIHKKSRNKCQY 164
Query: 159 CRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQS 193
CRF+KCL+VGMS +A+RFGR+P+ EK+++L E+ S
Sbjct: 165 CRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISS 199
Score = 117 bits (292), Expect = 4e-26
Identities = 65/168 (38%), Positives = 100/168 (59%), Gaps = 5/168 (2%)
Query: 412 AVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSV 471
AV+E+ E+AK IPGF +L +DQV LLK G E++ ASL + + V G+ +
Sbjct: 292 AVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN--KDGVLISEGQGFMT 349
Query: 472 DD-LHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEAL 528
+ L S+ GD + FEF+ K NAL+L D ++++F AV+++S DR G+ NV +E +
Sbjct: 350 REFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDI 409
Query: 529 QETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFK 576
Q+ L++AL + NHP + +F KLL K+ DLR + H + L K
Sbjct: 410 QDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK 457
>gi|48255918 RAR-related orphan receptor C isoform b [Homo sapiens]
Length = 497
Score = 130 bits (326), Expect = 4e-30
Identities = 78/185 (42%), Positives = 114/185 (61%), Gaps = 5/185 (2%)
Query: 396 KSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFD 455
KS E+WE + T A++ VVEFAKR+ GF +L Q+DQ+ LLKAG EV++VR ++
Sbjct: 290 KSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYN 349
Query: 456 AKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSAD 515
A RTV F GK ++ ++G +L++S+F+FS L+AL S++E++L+TA+VL++A
Sbjct: 350 ADNRTV-FFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAH 408
Query: 516 RSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAF 575
R G++ VE LQ L A + K H SI KL K LRSL + H E L F
Sbjct: 409 RPGLQEKRKVEQLQYNLELAFHHHLCKTH--RQSILAKLPPK-GKLRSLCSQHVERLQIF 465
Query: 576 K-VHP 579
+ +HP
Sbjct: 466 QHLHP 470
Score = 122 bits (306), Expect = 9e-28
Identities = 54/103 (52%), Positives = 73/103 (70%), Gaps = 1/103 (0%)
Query: 100 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQC 159
V+ CK+CGD +SG HYGV CEGCKGFFRRS + N Y C + +NC I R +RNRCQ C
Sbjct: 7 VIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYS-CTRQQNCPIDRTSRNRCQHC 65
Query: 160 RFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ 202
R +KCL++GMSRDAV+FGR+ K+++ + E+Q ++ Q
Sbjct: 66 RLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQ 108
>gi|19743909 RAR-related orphan receptor C isoform a [Homo sapiens]
Length = 518
Score = 130 bits (326), Expect = 4e-30
Identities = 78/185 (42%), Positives = 114/185 (61%), Gaps = 5/185 (2%)
Query: 396 KSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFD 455
KS E+WE + T A++ VVEFAKR+ GF +L Q+DQ+ LLKAG EV++VR ++
Sbjct: 311 KSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYN 370
Query: 456 AKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSAD 515
A RTV F GK ++ ++G +L++S+F+FS L+AL S++E++L+TA+VL++A
Sbjct: 371 ADNRTV-FFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAH 429
Query: 516 RSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAF 575
R G++ VE LQ L A + K H SI KL K LRSL + H E L F
Sbjct: 430 RPGLQEKRKVEQLQYNLELAFHHHLCKTH--RQSILAKLPPK-GKLRSLCSQHVERLQIF 486
Query: 576 K-VHP 579
+ +HP
Sbjct: 487 QHLHP 491
Score = 122 bits (306), Expect = 9e-28
Identities = 54/103 (52%), Positives = 73/103 (70%), Gaps = 1/103 (0%)
Query: 100 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQC 159
V+ CK+CGD +SG HYGV CEGCKGFFRRS + N Y C + +NC I R +RNRCQ C
Sbjct: 28 VIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYS-CTRQQNCPIDRTSRNRCQHC 86
Query: 160 RFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ 202
R +KCL++GMSRDAV+FGR+ K+++ + E+Q ++ Q
Sbjct: 87 RLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQ 129
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 130 bits (326), Expect = 4e-30
Identities = 68/198 (34%), Positives = 120/198 (60%), Gaps = 5/198 (2%)
Query: 383 VCPMSKSPYVDPH--KSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKA 440
V P +P DPH ++ + + F+ +V+E+V+FAK++PGF LS+ DQ+ LLK
Sbjct: 190 VTPWPMAP--DPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKT 247
Query: 441 GTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAG-DLLNSMFEFSEKLNALQLS 499
EV+++ + ++ ++TFL Y+ +D G + +N +FEFS +N LQL+
Sbjct: 248 SAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLN 307
Query: 500 DEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLP 559
D E +L A+ + SADR +++ VE LQ T + AL + +HP++ +F ++L+KL
Sbjct: 308 DAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLV 367
Query: 560 DLRSLNNMHSEELLAFKV 577
LR+L+++HSE++ A ++
Sbjct: 368 SLRTLSSVHSEQVFALRL 385
Score = 85.1 bits (209), Expect = 2e-16
Identities = 39/91 (42%), Positives = 56/91 (61%), Gaps = 7/91 (7%)
Query: 102 LCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRF 161
LC VCGD ASGFHY V +CEGCKGFFRRS+ + Y C +C + R +CQ+CR
Sbjct: 52 LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHY-ICHSGGHCPMDTYMRRKCQECRL 110
Query: 162 KKCLSVGM------SRDAVRFGRIPKREKQR 186
+KC GM S + +R ++ ++E+++
Sbjct: 111 RKCRQAGMREECVLSEEQIRLKKLKRQEEEQ 141
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 130 bits (326), Expect = 4e-30
Identities = 68/198 (34%), Positives = 120/198 (60%), Gaps = 5/198 (2%)
Query: 383 VCPMSKSPYVDPH--KSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKA 440
V P +P DPH ++ + + F+ +V+E+V+FAK++PGF LS+ DQ+ LLK
Sbjct: 235 VTPWPMAP--DPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKT 292
Query: 441 GTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAG-DLLNSMFEFSEKLNALQLS 499
EV+++ + ++ ++TFL Y+ +D G + +N +FEFS +N LQL+
Sbjct: 293 SAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLN 352
Query: 500 DEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLP 559
D E +L A+ + SADR +++ VE LQ T + AL + +HP++ +F ++L+KL
Sbjct: 353 DAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLV 412
Query: 560 DLRSLNNMHSEELLAFKV 577
LR+L+++HSE++ A ++
Sbjct: 413 SLRTLSSVHSEQVFALRL 430
Score = 85.1 bits (209), Expect = 2e-16
Identities = 39/91 (42%), Positives = 56/91 (61%), Gaps = 7/91 (7%)
Query: 102 LCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRF 161
LC VCGD ASGFHY V +CEGCKGFFRRS+ + Y C +C + R +CQ+CR
Sbjct: 97 LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHY-ICHSGGHCPMDTYMRRKCQECRL 155
Query: 162 KKCLSVGM------SRDAVRFGRIPKREKQR 186
+KC GM S + +R ++ ++E+++
Sbjct: 156 RKCRQAGMREECVLSEEQIRLKKLKRQEEEQ 186
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 129 bits (325), Expect = 6e-30
Identities = 62/177 (35%), Positives = 108/177 (61%)
Query: 401 IWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERT 460
+W++FS T + ++VEFAKR+PGF L+ DQ+ LLKA ++L++R + + ++ T
Sbjct: 217 LWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDT 276
Query: 461 VTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIE 520
+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +E
Sbjct: 277 MTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLE 336
Query: 521 NVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 577
V+ LQE L+ AL+ I K P++ +F K+L+K+ DLRS++ +E ++ K+
Sbjct: 337 EPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKM 393
Score = 105 bits (262), Expect = 1e-22
Identities = 47/82 (57%), Positives = 63/82 (76%), Gaps = 1/82 (1%)
Query: 103 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 162
C VC D +SG+HYGV ACEGCKGFFRRSIQ+N+ Y C +++NC I ++ RNRCQ CR +
Sbjct: 81 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIY-TCHRDKNCVINKVTRNRCQYCRLQ 139
Query: 163 KCLSVGMSRDAVRFGRIPKREK 184
KC VGMS+++VR R K+++
Sbjct: 140 KCFEVGMSKESVRNDRNKKKKE 161
>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
Length = 336
Score = 129 bits (325), Expect = 6e-30
Identities = 62/177 (35%), Positives = 108/177 (61%)
Query: 401 IWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERT 460
+W++FS T + ++VEFAKR+PGF L+ DQ+ LLKA ++L++R + + ++ T
Sbjct: 105 LWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDT 164
Query: 461 VTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIE 520
+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +E
Sbjct: 165 MTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLE 224
Query: 521 NVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 577
V+ LQE L+ AL+ I K P++ +F K+L+K+ DLRS++ +E ++ K+
Sbjct: 225 EPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKM 281
Score = 52.8 bits (125), Expect = 9e-07
Identities = 21/45 (46%), Positives = 33/45 (73%)
Query: 140 CLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREK 184
C +++NC I ++ RNRCQ CR +KC VGMS+++VR R K+++
Sbjct: 5 CHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKE 49
>gi|50348666 peroxisome proliferative activated receptor, alpha
[Homo sapiens]
Length = 468
Score = 129 bits (324), Expect = 7e-30
Identities = 55/100 (55%), Positives = 76/100 (76%), Gaps = 2/100 (2%)
Query: 103 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 162
C++CGD ASG+HYGVHACEGCKGFFRR+I+ + Y KC + +C I + NRN+CQ CRF
Sbjct: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKC--DRSCKIQKKNRNKCQYCRFH 159
Query: 163 KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ 202
KCLSVGMS +A+RFGR+P+ EK ++ E+ + + +S+
Sbjct: 160 KCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSE 199
Score = 111 bits (277), Expect = 2e-24
Identities = 60/160 (37%), Positives = 94/160 (58%), Gaps = 3/160 (1%)
Query: 413 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 472
V E+ EFAK IPGF +L +DQV LLK G +E + +S+ + V + +G + +
Sbjct: 284 VTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF-ITRE 342
Query: 473 DLHSMGAG--DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQE 530
L S+ D++ F+F+ K NAL+L D ++SLF A ++ DR G+ NV +E +QE
Sbjct: 343 FLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQE 402
Query: 531 TLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSE 570
++ LR + NHP++ +F KLL K+ DLR L H++
Sbjct: 403 GIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQ 442
>gi|7549811 peroxisome proliferative activated receptor, alpha [Homo
sapiens]
Length = 468
Score = 129 bits (324), Expect = 7e-30
Identities = 55/100 (55%), Positives = 76/100 (76%), Gaps = 2/100 (2%)
Query: 103 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 162
C++CGD ASG+HYGVHACEGCKGFFRR+I+ + Y KC + +C I + NRN+CQ CRF
Sbjct: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKC--DRSCKIQKKNRNKCQYCRFH 159
Query: 163 KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ 202
KCLSVGMS +A+RFGR+P+ EK ++ E+ + + +S+
Sbjct: 160 KCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSE 199
Score = 111 bits (277), Expect = 2e-24
Identities = 60/160 (37%), Positives = 94/160 (58%), Gaps = 3/160 (1%)
Query: 413 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 472
V E+ EFAK IPGF +L +DQV LLK G +E + +S+ + V + +G + +
Sbjct: 284 VTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF-ITRE 342
Query: 473 DLHSMGAG--DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQE 530
L S+ D++ F+F+ K NAL+L D ++SLF A ++ DR G+ NV +E +QE
Sbjct: 343 FLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQE 402
Query: 531 TLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSE 570
++ LR + NHP++ +F KLL K+ DLR L H++
Sbjct: 403 GIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQ 442
>gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens]
Length = 365
Score = 127 bits (319), Expect = 3e-29
Identities = 60/178 (33%), Positives = 108/178 (60%)
Query: 400 EIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKER 459
++W++FS T + + VEFAK++PGF L+ DQ+ LLKA ++L++R + + ++
Sbjct: 126 DLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQD 185
Query: 460 TVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGI 519
T+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +
Sbjct: 186 TMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDL 245
Query: 520 ENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 577
E + V+ LQE L+ AL+ + K P+ +F K+L+K+ DLRS++ +E ++ K+
Sbjct: 246 EQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKM 303
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 127 bits (319), Expect = 3e-29
Identities = 60/178 (33%), Positives = 108/178 (60%)
Query: 400 EIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKER 459
++W++FS T + + VEFAK++PGF L+ DQ+ LLKA ++L++R + + ++
Sbjct: 223 DLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQD 282
Query: 460 TVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGI 519
T+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +
Sbjct: 283 TMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDL 342
Query: 520 ENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 577
E + V+ LQE L+ AL+ + K P+ +F K+L+K+ DLRS++ +E ++ K+
Sbjct: 343 EQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKM 400
Score = 107 bits (266), Expect = 4e-23
Identities = 51/110 (46%), Positives = 73/110 (66%), Gaps = 1/110 (0%)
Query: 75 SMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQN 134
+++T SS+ + S + C VC D +SG+HYGV ACEGCKGFFRRSIQ+N
Sbjct: 60 TIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKN 119
Query: 135 IQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREK 184
+ Y C +++NC I ++ RNRCQ CR +KC VGMS+++VR R K+++
Sbjct: 120 MVY-TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKE 168
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 127 bits (319), Expect = 3e-29
Identities = 60/178 (33%), Positives = 108/178 (60%)
Query: 400 EIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKER 459
++W++FS T + + VEFAK++PGF L+ DQ+ LLKA ++L++R + + ++
Sbjct: 218 DLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQD 277
Query: 460 TVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGI 519
T+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +
Sbjct: 278 TMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDL 337
Query: 520 ENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 577
E + V+ LQE L+ AL+ + K P+ +F K+L+K+ DLRS++ +E ++ K+
Sbjct: 338 EQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKM 395
Score = 108 bits (269), Expect = 2e-23
Identities = 52/110 (47%), Positives = 73/110 (66%), Gaps = 1/110 (0%)
Query: 75 SMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQN 134
S++T SS+ + S + C VC D +SG+HYGV ACEGCKGFFRRSIQ+N
Sbjct: 55 SIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKN 114
Query: 135 IQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREK 184
+ Y C +++NC I ++ RNRCQ CR +KC VGMS+++VR R K+++
Sbjct: 115 MVY-TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKE 163
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 127 bits (319), Expect = 3e-29
Identities = 60/178 (33%), Positives = 108/178 (60%)
Query: 400 EIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKER 459
++W++FS T + + VEFAK++PGF L+ DQ+ LLKA ++L++R + + ++
Sbjct: 223 DLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQD 282
Query: 460 TVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGI 519
T+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +
Sbjct: 283 TMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDL 342
Query: 520 ENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 577
E + V+ LQE L+ AL+ + K P+ +F K+L+K+ DLRS++ +E ++ K+
Sbjct: 343 EQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKM 400
Score = 107 bits (266), Expect = 4e-23
Identities = 51/110 (46%), Positives = 73/110 (66%), Gaps = 1/110 (0%)
Query: 75 SMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQN 134
+++T SS+ + S + C VC D +SG+HYGV ACEGCKGFFRRSIQ+N
Sbjct: 60 TIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKN 119
Query: 135 IQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREK 184
+ Y C +++NC I ++ RNRCQ CR +KC VGMS+++VR R K+++
Sbjct: 120 MVY-TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKE 168
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 126 bits (317), Expect = 5e-29
Identities = 61/177 (34%), Positives = 105/177 (59%)
Query: 401 IWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERT 460
+W++FS T + ++VEFAKR+PGF LS DQ+ LLKA ++LM+R + + ++ T
Sbjct: 215 LWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDT 274
Query: 461 VTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIE 520
+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +E
Sbjct: 275 MTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLE 334
Query: 521 NVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 577
V+ LQE L+ ALR + P++ +F ++L+K+ DLR ++ +E + K+
Sbjct: 335 EPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKM 391
Score = 108 bits (269), Expect = 2e-23
Identities = 52/110 (47%), Positives = 73/110 (66%), Gaps = 1/110 (0%)
Query: 75 SMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQN 134
S++T +S+ M S + C VC D +SG+HYGV +CEGCKGFFRRSIQ+N
Sbjct: 51 SVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKN 110
Query: 135 IQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREK 184
+ Y C +++NC I ++ RNRCQ CR +KC VGMS++AVR R K+++
Sbjct: 111 MVY-TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKE 159
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 126 bits (317), Expect = 5e-29
Identities = 61/177 (34%), Positives = 105/177 (59%)
Query: 401 IWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERT 460
+W++FS T + ++VEFAKR+PGF LS DQ+ LLKA ++LM+R + + ++ T
Sbjct: 226 LWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDT 285
Query: 461 VTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIE 520
+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +E
Sbjct: 286 MTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLE 345
Query: 521 NVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 577
V+ LQE L+ ALR + P++ +F ++L+K+ DLR ++ +E + K+
Sbjct: 346 EPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKM 402
Score = 108 bits (271), Expect = 1e-23
Identities = 53/118 (44%), Positives = 75/118 (63%), Gaps = 1/118 (0%)
Query: 67 LKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGF 126
L + S++T +S+ M S + C VC D +SG+HYGV +CEGCKGF
Sbjct: 54 LPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGF 113
Query: 127 FRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREK 184
FRRSIQ+N+ Y C +++NC I ++ RNRCQ CR +KC VGMS++AVR R K+++
Sbjct: 114 FRRSIQKNMVY-TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKE 170
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 123 bits (309), Expect = 4e-28
Identities = 62/167 (37%), Positives = 102/167 (61%), Gaps = 1/167 (0%)
Query: 412 AVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSV 471
+V+E+V+FAK++PGF L + DQ+ LLKA T E++++ A ++ + +TFL YS
Sbjct: 278 SVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSK 337
Query: 472 DDLHSMGAG-DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQE 530
DD H G + +N +FEFS + L L D E +L A+ + SADR ++ VEALQ+
Sbjct: 338 DDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQ 397
Query: 531 TLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 577
+ AL + P + F ++L+KL LR+L+++HSE++ A ++
Sbjct: 398 PYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRL 444
Score = 89.4 bits (220), Expect = 8e-18
Identities = 51/157 (32%), Positives = 74/157 (47%), Gaps = 18/157 (11%)
Query: 44 PNSSNSDTNGNPKNGDLANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLC 103
P + D G + + + ++ + + K K AP M LC
Sbjct: 39 PGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHE-----------LC 87
Query: 104 KVCGDVASGFHYGVHACEGCKGFFRRS-IQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 162
+VCGD ASGFHY V +CEGCKGFFRRS ++ + C C + R +CQQCR +
Sbjct: 88 RVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLR 147
Query: 163 KCLSVGM------SRDAVRFGRIPKREKQRMLIEMQS 193
KC GM S + +R +I K+++Q + QS
Sbjct: 148 KCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQS 184
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 111 bits (277), Expect = 2e-24
Identities = 68/202 (33%), Positives = 106/202 (52%), Gaps = 3/202 (1%)
Query: 379 RMHLVCPMSKSPYV---DPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQV 435
R L + +SP V D K E + EF+ TPA+ VV+FAK++P F +L DQ+
Sbjct: 189 RKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQI 248
Query: 436 NLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNA 495
LLK E++ +R A +D + T+T + L + G G + +++FE + L+A
Sbjct: 249 ILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSA 308
Query: 496 LQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLL 555
L D E++L AV+L+S DRSG+ V+ +E QE + A + N + KLL
Sbjct: 309 FNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLL 368
Query: 556 LKLPDLRSLNNMHSEELLAFKV 577
+K+ DLR + H+ L KV
Sbjct: 369 MKVTDLRMIGACHASRFLHMKV 390
Score = 98.6 bits (244), Expect = 1e-20
Identities = 55/145 (37%), Positives = 79/145 (54%), Gaps = 12/145 (8%)
Query: 47 SNSDTNGNPKNGDLANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVC 106
S + +P+ + +G K CS+KTS S + + C VC
Sbjct: 6 SKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGY---------IPSYLDKDEQCVVC 56
Query: 107 GDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIM-RMNRNRCQQCRFKKCL 165
GD A+G+HY CEGCKGFFRR+IQ+N+ K ++C ++ ++ RN+CQ CRFKKC+
Sbjct: 57 GDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCI 116
Query: 166 SVGMSRDAVRFGRIPKREKQRMLIE 190
+VGM+ D V KR +R LIE
Sbjct: 117 AVGMAMDLVLDD--SKRVAKRKLIE 139
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.129 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,980,296
Number of Sequences: 37866
Number of extensions: 1009592
Number of successful extensions: 6228
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 156
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 5288
Number of HSP's gapped (non-prelim): 580
length of query: 579
length of database: 18,247,518
effective HSP length: 108
effective length of query: 471
effective length of database: 14,157,990
effective search space: 6668413290
effective search space used: 6668413290
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.