Search of human proteins with 223941876

Search of human proteins with 223941876

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
         (913 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i...  1867   0.0  
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i...  1751   0.0  
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i...  1602   0.0  
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i...  1485   0.0  
gi|223941888 protein tyrosine phosphatase, non-receptor type 3 i...  1283   0.0  
gi|223941891 protein tyrosine phosphatase, non-receptor type 3 i...  1166   0.0  
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho...   940   0.0  
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor...   225   2e-58
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor...   225   2e-58
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ...   225   2e-58
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform...   225   2e-58
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform...   224   2e-58
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi...   224   4e-58
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s...   223   6e-58
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis...   222   1e-57
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [...   214   2e-55
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s...   207   5e-53
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]        196   6e-50
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi...   195   2e-49
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ...   194   2e-49
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform...   192   1e-48
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo...   191   3e-48
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo...   191   3e-48
gi|4506291 protein tyrosine phosphatase, non-receptor type 2 iso...   191   3e-48
gi|18104982 protein tyrosine phosphatase, non-receptor type 2 [H...   191   3e-48
gi|18104980 protein tyrosine phosphatase, non-receptor type 2 is...   191   3e-48
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...   190   6e-48
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...   190   6e-48
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...   190   6e-48
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...   190   6e-48

>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
           isoform 1 [Homo sapiens]
          Length = 913

 Score = 1867 bits (4836), Expect = 0.0
 Identities = 913/913 (100%), Positives = 913/913 (100%)

Query: 1   MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHN 60
           MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHN
Sbjct: 1   MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHN 60

Query: 61  HLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQE 120
           HLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQE
Sbjct: 61  HLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQE 120

Query: 121 QTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ 180
           QTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ
Sbjct: 121 QTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ 180

Query: 181 NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAG 240
           NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAG
Sbjct: 181 NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAG 240

Query: 241 VAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 300
           VAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS
Sbjct: 241 VAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 300

Query: 301 CVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSV 360
           CVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSV
Sbjct: 301 CVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSV 360

Query: 361 EHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 420
           EHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL
Sbjct: 361 EHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 420

Query: 421 APQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDD 480
           APQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDD
Sbjct: 421 APQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDD 480

Query: 481 FHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRI 540
           FHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRI
Sbjct: 481 FHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRI 540

Query: 541 NPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVR 600
           NPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVR
Sbjct: 541 NPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVR 600

Query: 601 SFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGL 660
           SFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGL
Sbjct: 601 SFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGL 660

Query: 661 AITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGP 720
           AITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGP
Sbjct: 661 AITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGP 720

Query: 721 LPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCT 780
           LPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCT
Sbjct: 721 LPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCT 780

Query: 781 IAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLV 840
           IAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLV
Sbjct: 781 IAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLV 840

Query: 841 HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 900
           HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
Sbjct: 841 HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 900

Query: 901 VYEEGLVQMLDPS 913
           VYEEGLVQMLDPS
Sbjct: 901 VYEEGLVQMLDPS 913


>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
           isoform 2 [Homo sapiens]
          Length = 868

 Score = 1751 bits (4534), Expect = 0.0
 Identities = 868/913 (95%), Positives = 868/913 (95%), Gaps = 45/913 (4%)

Query: 1   MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHN 60
           MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHN
Sbjct: 1   MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHN 60

Query: 61  HLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQE 120
           HLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQE
Sbjct: 61  HLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQE 120

Query: 121 QTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ 180
           QTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ
Sbjct: 121 QTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ 180

Query: 181 NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAG 240
           NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAG
Sbjct: 181 NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAG 240

Query: 241 VAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 300
           VAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS
Sbjct: 241 VAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 300

Query: 301 CVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSV 360
           CVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKK                          
Sbjct: 301 CVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKK-------------------------- 334

Query: 361 EHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 420
                              RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL
Sbjct: 335 -------------------RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 375

Query: 421 APQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDD 480
           APQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDD
Sbjct: 376 APQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDD 435

Query: 481 FHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRI 540
           FHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRI
Sbjct: 436 FHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRI 495

Query: 541 NPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVR 600
           NPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVR
Sbjct: 496 NPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVR 555

Query: 601 SFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGL 660
           SFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGL
Sbjct: 556 SFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGL 615

Query: 661 AITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGP 720
           AITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGP
Sbjct: 616 AITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGP 675

Query: 721 LPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCT 780
           LPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCT
Sbjct: 676 LPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCT 735

Query: 781 IAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLV 840
           IAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLV
Sbjct: 736 IAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLV 795

Query: 841 HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 900
           HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
Sbjct: 796 HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 855

Query: 901 VYEEGLVQMLDPS 913
           VYEEGLVQMLDPS
Sbjct: 856 VYEEGLVQMLDPS 868


>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
           isoform 3 [Homo sapiens]
          Length = 782

 Score = 1602 bits (4147), Expect = 0.0
 Identities = 782/782 (100%), Positives = 782/782 (100%)

Query: 132 MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 191
           MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL
Sbjct: 1   MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 60

Query: 192 HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 251
           HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS
Sbjct: 61  HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 120

Query: 252 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 311
           FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK
Sbjct: 121 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 180

Query: 312 KLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSR 371
           KLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSR
Sbjct: 181 KLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSR 240

Query: 372 SPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ 431
           SPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ
Sbjct: 241 SPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ 300

Query: 432 NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE 491
           NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE
Sbjct: 301 NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE 360

Query: 492 DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP 551
           DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP
Sbjct: 361 DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP 420

Query: 552 KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL 611
           KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL
Sbjct: 421 KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL 480

Query: 612 NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL 671
           NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL
Sbjct: 481 NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL 540

Query: 672 DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 731
           DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV
Sbjct: 541 DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 600

Query: 732 VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT 791
           VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT
Sbjct: 601 VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT 660

Query: 792 NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV 851
           NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV
Sbjct: 661 NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV 720

Query: 852 LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD 911
           LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD
Sbjct: 721 LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD 780

Query: 912 PS 913
           PS
Sbjct: 781 PS 782


>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
           isoform 4 [Homo sapiens]
          Length = 737

 Score = 1485 bits (3845), Expect = 0.0
 Identities = 737/782 (94%), Positives = 737/782 (94%), Gaps = 45/782 (5%)

Query: 132 MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 191
           MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL
Sbjct: 1   MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 60

Query: 192 HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 251
           HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS
Sbjct: 61  HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 120

Query: 252 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 311
           FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK
Sbjct: 121 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 180

Query: 312 KLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSR 371
           KLLPQEKNVLSQYWTMGSRNTKK                                     
Sbjct: 181 KLLPQEKNVLSQYWTMGSRNTKK------------------------------------- 203

Query: 372 SPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ 431
                   RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ
Sbjct: 204 --------RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ 255

Query: 432 NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE 491
           NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE
Sbjct: 256 NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE 315

Query: 492 DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP 551
           DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP
Sbjct: 316 DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP 375

Query: 552 KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL 611
           KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL
Sbjct: 376 KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL 435

Query: 612 NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL 671
           NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL
Sbjct: 436 NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL 495

Query: 672 DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 731
           DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV
Sbjct: 496 DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 555

Query: 732 VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT 791
           VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT
Sbjct: 556 VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT 615

Query: 792 NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV 851
           NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV
Sbjct: 616 NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV 675

Query: 852 LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD 911
           LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD
Sbjct: 676 LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD 735

Query: 912 PS 913
           PS
Sbjct: 736 PS 737


>gi|223941888 protein tyrosine phosphatase, non-receptor type 3
           isoform 5 [Homo sapiens]
          Length = 626

 Score = 1283 bits (3319), Expect = 0.0
 Identities = 626/626 (100%), Positives = 626/626 (100%)

Query: 288 MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGG 347
           MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGG
Sbjct: 1   MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGG 60

Query: 348 MVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYIT 407
           MVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYIT
Sbjct: 61  MVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYIT 120

Query: 408 ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGS 467
           ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGS
Sbjct: 121 ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGS 180

Query: 468 CSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKG 527
           CSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKG
Sbjct: 181 CSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKG 240

Query: 528 GVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHS 587
           GVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHS
Sbjct: 241 GVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHS 300

Query: 588 RELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVL 647
           RELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVL
Sbjct: 301 RELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVL 360

Query: 648 IQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPA 707
           IQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPA
Sbjct: 361 IQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPA 420

Query: 708 ANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNH 767
           ANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNH
Sbjct: 421 ANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNH 480

Query: 768 GGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNY 827
           GGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNY
Sbjct: 481 GGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNY 540

Query: 828 VRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQT 887
           VRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQT
Sbjct: 541 VRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQT 600

Query: 888 SSQYKFVCEAILRVYEEGLVQMLDPS 913
           SSQYKFVCEAILRVYEEGLVQMLDPS
Sbjct: 601 SSQYKFVCEAILRVYEEGLVQMLDPS 626


>gi|223941891 protein tyrosine phosphatase, non-receptor type 3
           isoform 6 [Homo sapiens]
          Length = 581

 Score = 1166 bits (3017), Expect = 0.0
 Identities = 581/626 (92%), Positives = 581/626 (92%), Gaps = 45/626 (7%)

Query: 288 MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGG 347
           MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKK             
Sbjct: 1   MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKK------------- 47

Query: 348 MVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYIT 407
                                           RSPRLRHEIRKPRHSSADNLANEMTYIT
Sbjct: 48  --------------------------------RSPRLRHEIRKPRHSSADNLANEMTYIT 75

Query: 408 ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGS 467
           ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGS
Sbjct: 76  ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGS 135

Query: 468 CSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKG 527
           CSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKG
Sbjct: 136 CSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKG 195

Query: 528 GVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHS 587
           GVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHS
Sbjct: 196 GVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHS 255

Query: 588 RELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVL 647
           RELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVL
Sbjct: 256 RELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVL 315

Query: 648 IQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPA 707
           IQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPA
Sbjct: 316 IQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPA 375

Query: 708 ANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNH 767
           ANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNH
Sbjct: 376 ANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNH 435

Query: 768 GGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNY 827
           GGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNY
Sbjct: 436 GGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNY 495

Query: 828 VRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQT 887
           VRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQT
Sbjct: 496 VRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQT 555

Query: 888 SSQYKFVCEAILRVYEEGLVQMLDPS 913
           SSQYKFVCEAILRVYEEGLVQMLDPS
Sbjct: 556 SSQYKFVCEAILRVYEEGLVQMLDPS 581


>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
           sapiens]
          Length = 926

 Score =  940 bits (2430), Expect = 0.0
 Identities = 489/951 (51%), Positives = 638/951 (67%), Gaps = 66/951 (6%)

Query: 1   MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHN 60
           MTSR R   GR  N+R SEL +++  +EV+C+I  LD  VQ FKV K D GQVLLD+V  
Sbjct: 1   MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFK 60

Query: 61  HLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQE 120
           HL +TE++YFGLQ  DDS D+PRWL+ +K IRKQLK G P +L+FRV+FF+ DPN LQ+E
Sbjct: 61  HLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEE 120

Query: 121 QTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ 180
            TR+ YFLQ+K DI  GRL CP N+A +LAS+AVQS  GDY+ S +  GYLSD  FIP+Q
Sbjct: 121 YTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQ 180

Query: 181 NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAG 240
            +DF  ++  LH+QH GL  +EAE  Y+N ARTL+ YGVE H  RD  N ++MIG+ S G
Sbjct: 181 PQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGG 240

Query: 241 VAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 300
           + +Y+  +  + +PW+ I+KISFK K+FFI  R++  ESRE ++ FNM+NYR+CKNLWK+
Sbjct: 241 ILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKA 300

Query: 301 CVEHHTFFQAKKLLPQEKNVLSQYWTMGS------RNTKKSVNNQYCKKVIGG------- 347
           CVEHHTFF+  + LP +KN  + Y+T+GS      R   +SV  QY K+           
Sbjct: 301 CVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSV--QYGKEKANKDRVFARS 358

Query: 348 ---------MVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADN 398
                    M W    R S+S + LET+SLPSRSPP TPN R+     E  + R SS  +
Sbjct: 359 PSKPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGH 418

Query: 399 LANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSV 458
           L + M + T   +VF                   RSP       +  A S + + S S  
Sbjct: 419 LVDHMVH-TSPSEVFV----------------NQRSP------SSTQANSIVLESSPSQE 455

Query: 459 SPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKND----------NG---D 505
           +P    P +  P    Q   + ++++    S +D   +  +  D          NG    
Sbjct: 456 TPGDGKPPALPP---KQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIPH 512

Query: 506 SYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGR 565
             LVLIR+ PDE+G+FGFN+KGG DQKMP++VSR+ P +PAD C+P+LNEGDQ+VLINGR
Sbjct: 513 DNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVVLINGR 572

Query: 566 DISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELN-QLFPE-AIFPMC 623
           DI+EHTHDQVV+FIKAS E HS EL L++R  AV    + K E+E + Q  PE A     
Sbjct: 573 DIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEEKLENEPDFQYIPEKAPLDSV 632

Query: 624 PEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYD 683
            +   +L  SM QL +GL +GTVL QF+QLYRKKPG+ ++ AKLPQN+ KNRY+D+ PYD
Sbjct: 633 HQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYD 692

Query: 684 TTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVML 743
            TRV+L+GNEDYINA+Y+NMEIP+++++N+YIA QGPLPHTC  FWQ+ W+Q  S++VML
Sbjct: 693 ATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVML 752

Query: 744 TTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTH 803
           TT  ERGR KCHQYWP+P    ++G + + C SE+   AY+ R+M + N +  E   +T 
Sbjct: 753 TTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQ 812

Query: 804 LQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-DSEPVLVHCSAGIGRTGVLVTMETAMCLT 862
           +QY+AWPDHGVPDDSSDFL+FV +VR+ R    EPV+VHCSAGIGRTGVL+TMETAMCL 
Sbjct: 813 IQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLI 872

Query: 863 ERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS 913
           E N P+YPLDIVR MRDQRAMM+QT SQY+FVCEAIL+VYEEG V+ L  S
Sbjct: 873 ECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVKPLTTS 923


>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score =  225 bits (573), Expect = 2e-58
 Identities = 117/323 (36%), Positives = 184/323 (56%), Gaps = 12/323 (3%)

Query: 15  IRTSELPKEKTRSEVI-------CSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEK 67
           ++T+EL  EK   +V        C +  LDG   +  + K   GQVL D V  HL + EK
Sbjct: 197 VQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEK 256

Query: 68  EYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYF 127
           +YFGL   + S +   WL+ +K I++QL+   P    F V+F+ PDP+ L ++ TR+   
Sbjct: 257 DYFGLLFQE-SPEQKNWLDPAKEIKRQLRN-LPWLFTFNVKFYPPDPSQLTEDITRYFLC 314

Query: 128 LQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTK 187
           LQL+ DI  GRL C   +  +L SY +Q+  GDY+   H    LS+  F P Q ++   K
Sbjct: 315 LQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEK 374

Query: 188 VESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKY 247
           V  LH+ H GL  ++A+S ++  A+ L  YGV+LH  +D   +D+ +G+ + G+ +Y+  
Sbjct: 375 VAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDR 434

Query: 248 ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTF 307
           +  + + W  ILKIS+KR  F+I  R  + E  E  + F + N+R+ K LWK CVEHHTF
Sbjct: 435 LRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTF 494

Query: 308 FQAKKLLPQEKNVLSQYWTMGSR 330
           +   +L+  E+   +++ T+GS+
Sbjct: 495 Y---RLVSPEQPPKAKFLTLGSK 514


>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score =  225 bits (573), Expect = 2e-58
 Identities = 117/323 (36%), Positives = 184/323 (56%), Gaps = 12/323 (3%)

Query: 15  IRTSELPKEKTRSEVI-------CSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEK 67
           ++T+EL  EK   +V        C +  LDG   +  + K   GQVL D V  HL + EK
Sbjct: 197 VQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEK 256

Query: 68  EYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYF 127
           +YFGL   + S +   WL+ +K I++QL+   P    F V+F+ PDP+ L ++ TR+   
Sbjct: 257 DYFGLLFQE-SPEQKNWLDPAKEIKRQLRN-LPWLFTFNVKFYPPDPSQLTEDITRYFLC 314

Query: 128 LQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTK 187
           LQL+ DI  GRL C   +  +L SY +Q+  GDY+   H    LS+  F P Q ++   K
Sbjct: 315 LQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEK 374

Query: 188 VESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKY 247
           V  LH+ H GL  ++A+S ++  A+ L  YGV+LH  +D   +D+ +G+ + G+ +Y+  
Sbjct: 375 VAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDR 434

Query: 248 ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTF 307
           +  + + W  ILKIS+KR  F+I  R  + E  E  + F + N+R+ K LWK CVEHHTF
Sbjct: 435 LRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTF 494

Query: 308 FQAKKLLPQEKNVLSQYWTMGSR 330
           +   +L+  E+   +++ T+GS+
Sbjct: 495 Y---RLVSPEQPPKAKFLTLGSK 514


>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
           [Homo sapiens]
          Length = 1005

 Score =  225 bits (573), Expect = 2e-58
 Identities = 117/323 (36%), Positives = 184/323 (56%), Gaps = 12/323 (3%)

Query: 15  IRTSELPKEKTRSEVI-------CSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEK 67
           ++T+EL  EK   +V        C +  LDG   +  + K   GQVL D V  HL + EK
Sbjct: 197 VQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEK 256

Query: 68  EYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYF 127
           +YFGL   + S +   WL+ +K I++QL+   P    F V+F+ PDP+ L ++ TR+   
Sbjct: 257 DYFGLLFQE-SPEQKNWLDPAKEIKRQLRN-LPWLFTFNVKFYPPDPSQLTEDITRYFLC 314

Query: 128 LQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTK 187
           LQL+ DI  GRL C   +  +L SY +Q+  GDY+   H    LS+  F P Q ++   K
Sbjct: 315 LQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEK 374

Query: 188 VESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKY 247
           V  LH+ H GL  ++A+S ++  A+ L  YGV+LH  +D   +D+ +G+ + G+ +Y+  
Sbjct: 375 VAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDR 434

Query: 248 ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTF 307
           +  + + W  ILKIS+KR  F+I  R  + E  E  + F + N+R+ K LWK CVEHHTF
Sbjct: 435 LRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTF 494

Query: 308 FQAKKLLPQEKNVLSQYWTMGSR 330
           +   +L+  E+   +++ T+GS+
Sbjct: 495 Y---RLVSPEQPPKAKFLTLGSK 514


>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
           [Homo sapiens]
          Length = 779

 Score =  225 bits (573), Expect = 2e-58
 Identities = 141/422 (33%), Positives = 212/422 (50%), Gaps = 39/422 (9%)

Query: 24  KTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPR 83
           K     IC +  LD      +V K   GQVL D+V  HL + EK+YFGL   D   DS +
Sbjct: 30  KKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCD--ADSQK 87

Query: 84  -WLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCP 142
            WL+ SK I+KQ++   P    F V+F+ PDP  L ++ TR+   LQL+ DI  GRL C 
Sbjct: 88  NWLDPSKEIKKQIRSS-PWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCS 146

Query: 143 LNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSE 202
             +  +L SYAVQ+  GDY++  H   Y+S+  F P+Q  +   ++  LH+ + G+   E
Sbjct: 147 FVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGE 206

Query: 203 AESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKIS 262
           AE  ++  A+ L  YGV+LH  +D   +D+M+G+ + G+ +YR  +  + + W  ILKIS
Sbjct: 207 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKIS 266

Query: 263 FKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLS 322
           +KR  F+I  R  + E  E  + F + N+RS K LWK C+EHHTFF+     P  K  L 
Sbjct: 267 YKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFL- 325

Query: 323 QYWTMGSRNTKKSVNNQYCKKVIGGMVWNPA--MRRSLSVEHLETKSLP----SRSPPIT 376
               MGS+  + S   Q   +    ++  PA    RS S  +  ++SL     SR   ++
Sbjct: 326 ---VMGSK-FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVS 381

Query: 377 PN------------------WRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKG 418
            N                   RS     E+R P          E+ ++ + EDV   ++ 
Sbjct: 382 ENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTP------TKIKELKFLDKPEDVLLKHQA 435

Query: 419 SL 420
           S+
Sbjct: 436 SI 437


>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
           [Homo sapiens]
          Length = 881

 Score =  224 bits (572), Expect = 2e-58
 Identities = 128/348 (36%), Positives = 189/348 (54%), Gaps = 11/348 (3%)

Query: 24  KTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPR 83
           K     IC +  LD      +V K   GQVL D+V  HL + EK+YFGL   D   DS +
Sbjct: 92  KKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCD--ADSQK 149

Query: 84  -WLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCP 142
            WL+ SK I+KQ++   P    F V+F+ PDP  L ++ TR+   LQL+ DI  GRL C 
Sbjct: 150 NWLDPSKEIKKQIRSS-PWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCS 208

Query: 143 LNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSE 202
             +  +L SYAVQ+  GDY++  H   Y+S+  F P+Q  +   ++  LH+ + G+   E
Sbjct: 209 FVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGE 268

Query: 203 AESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKIS 262
           AE  ++  A+ L  YGV+LH  +D   +D+M+G+ + G+ +YR  +  + + W  ILKIS
Sbjct: 269 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKIS 328

Query: 263 FKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLS 322
           +KR  F+I  R  + E  E  + F + N+RS K LWK C+EHHTFF+     P  K  L 
Sbjct: 329 YKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFL- 387

Query: 323 QYWTMGSRNTKKSVNNQYCKKVIGGMVWNPA--MRRSLSVEHLETKSL 368
               MGS+  + S   Q   +    ++  PA    RS S  +  ++SL
Sbjct: 388 ---VMGSK-FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSL 431


>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
           1, RH-linked) isoform 2 [Homo sapiens]
          Length = 641

 Score =  224 bits (570), Expect = 4e-58
 Identities = 137/438 (31%), Positives = 229/438 (52%), Gaps = 25/438 (5%)

Query: 31  CSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKA 90
           C +  LD  V    V K   GQ LL  V  HL + E++YFGL   D++  S  WL+++K 
Sbjct: 3   CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNAT-SKTWLDSAKE 61

Query: 91  IRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLA 150
           I+KQ++G  P    F V+F+ PDP  L ++ TR+   LQL+ DI  GRL C   +  +L 
Sbjct: 62  IKKQVRG-VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120

Query: 151 SYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINI 210
           SY +QS  GDY+  +H   Y+SD    P+Q ++   KV  LH+ +  +  ++A+  ++  
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180

Query: 211 ARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFI 270
           A+ L  YGV+LH  +DL  +D+++G+ S+G+ VY+  +  + +PW  +LKIS+KR  FFI
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240

Query: 271 HQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSR 330
             R  + E  E  + F + +YR+ K LWK CVEHHTFF   +L   +    S++  +GS+
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFF---RLTSTDTIPKSKFLALGSK 297

Query: 331 NTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRK 390
             + S   Q   +    ++  PA     +     ++SL   +   + +          R 
Sbjct: 298 -FRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSAD----------RS 346

Query: 391 PRHSSADNLANEMTYITETEDVFYTYKGSLAP----QDSDSEVSQNRSPHQESLSENNPA 446
           PR +SA  +      + E   +  + K ++ P    +   +EV +   P ++  +E  P 
Sbjct: 347 PRPTSAPAITQGQ--VAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQ--AEPEPT 402

Query: 447 QSYLTQKSSSSVS-PSSN 463
           +++  +K+   V+ P+SN
Sbjct: 403 EAWKVEKTHIEVTVPTSN 420


>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
           sapiens]
          Length = 1087

 Score =  223 bits (568), Expect = 6e-58
 Identities = 127/358 (35%), Positives = 197/358 (55%), Gaps = 9/358 (2%)

Query: 13  NNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGL 72
           + +  S L   K    + C +  LDG   T  V K+  GQVL D V  HL + EK+YFGL
Sbjct: 94  SKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGL 153

Query: 73  QHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKM 132
            + D + +   WL+ +K I+KQ++ G      F V+F+ PDP  L ++ TR+   LQL+ 
Sbjct: 154 TYRD-AENQKNWLDPAKEIKKQVRSG-AWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRD 211

Query: 133 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 192
           DI  GRL C   +  +L SY VQS  GDY+       Y+S+  F P+  ++   KV  LH
Sbjct: 212 DIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELH 271

Query: 193 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 252
           + H G+  +EAE  ++  A+ L  YGV+LH  +D   +++M+G+ ++G+ +YR  +  + 
Sbjct: 272 KSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINR 331

Query: 253 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 312
           + W  +LKIS+KR  F+I  R  + E  E  + F + N+R+ K LWK CVEHHTFF  + 
Sbjct: 332 FAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFF--RL 389

Query: 313 LLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPA--MRRSLSVEHLETKSL 368
           LLP+      ++ T+GS+  + S   Q   +    ++  PA    RS S  +  ++SL
Sbjct: 390 LLPEAPP--KKFLTLGSK-FRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSL 444


>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
           RH-linked) isoform 3 [Homo sapiens]
          Length = 588

 Score =  222 bits (566), Expect = 1e-57
 Identities = 123/353 (34%), Positives = 195/353 (55%), Gaps = 7/353 (1%)

Query: 31  CSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKA 90
           C +  LD  V    V K   GQ LL  V  HL + E++YFGL   D++  S  WL+++K 
Sbjct: 3   CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNAT-SKTWLDSAKE 61

Query: 91  IRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLA 150
           I+KQ++G  P    F V+F+ PDP  L ++ TR+   LQL+ DI  GRL C   +  +L 
Sbjct: 62  IKKQVRG-VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120

Query: 151 SYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINI 210
           SY +QS  GDY+  +H   Y+SD    P+Q ++   KV  LH+ +  +  ++A+  ++  
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180

Query: 211 ARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFI 270
           A+ L  YGV+LH  +DL  +D+++G+ S+G+ VY+  +  + +PW  +LKIS+KR  FFI
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240

Query: 271 HQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSR 330
             R  + E  E  + F + +YR+ K LWK CVEHHTFF   +L   +    S++  +GS+
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFF---RLTSTDTIPKSKFLALGSK 297

Query: 331 NTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPR 383
             + S   Q   +    ++  PA     +     ++SL   +   + + RSPR
Sbjct: 298 -FRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSAD-RSPR 348


>gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [Homo
            sapiens]
          Length = 1187

 Score =  214 bits (546), Expect = 2e-55
 Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 20/282 (7%)

Query: 637  LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGN 692
            LKK LE G V  ++EQ+ +KK     + A LP+N +++R ++V+PY+  RV L    + N
Sbjct: 900  LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959

Query: 693  EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 752
              YINAS++ + +  A     YIATQGPLPHTC  FWQ+VW+Q +++I M+T   E GRT
Sbjct: 960  TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017

Query: 753  KCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW 809
            K H+YWP          +G F +  +    ++ Y +  + V +  +G+E TV HLQY  W
Sbjct: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077

Query: 810  PDHGVPDDSSDFLEFVNYVRSLRVDSE-----------PVLVHCSAGIGRTGVLVTMETA 858
            PDHG P+D   FL ++  ++S+R  +            P++VHCSAG+GRTGVL+  E  
Sbjct: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137

Query: 859  MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 900
            +   E N  +    ++R +R+QR  M+QT +QYKFV + +++
Sbjct: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179



 Score =  129 bits (323), Expect = 2e-29
 Identities = 90/299 (30%), Positives = 143/299 (47%), Gaps = 16/299 (5%)

Query: 30  ICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASK 89
           +  I  LD  V    ++ + TGQ  L+ V   L + E  YFGL     S  + RW+E  K
Sbjct: 22  VTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQA-RWVELEK 80

Query: 90  AIRKQL-KGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVV 148
            ++K L K      L F V F++P+ + LQQE TR+ Y+LQ+K D+ EGRL C L+  + 
Sbjct: 81  PLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIR 140

Query: 149 LASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ-------NEDFLTKVESLHEQHSGLKQS 201
           LA  AVQ+ FGDYN       +L +    P          E+   KV   H+ HSG+  +
Sbjct: 141 LAGLAVQADFGDYN-QFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPA 199

Query: 202 EAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS-FYPWVNILK 260
           EAE  YIN    LD +G E+   +D H   + +GI   G+ V  +    +  Y W ++  
Sbjct: 200 EAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGN 259

Query: 261 ISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKN 319
           I+  +    +     +  ++E    F+  +  + K + +     H F++  K+  ++ N
Sbjct: 260 ITHNKSTILV-----ELINKEETALFHTDDIENAKYISRLFATRHKFYKQNKICTEQSN 313


>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
           sapiens]
          Length = 733

 Score =  207 bits (526), Expect = 5e-53
 Identities = 107/308 (34%), Positives = 178/308 (57%), Gaps = 4/308 (1%)

Query: 25  TRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRW 84
           ++S + C +  LDG   +  + K+  GQ L D +  HL + E +YFGL+  D S     W
Sbjct: 39  SKSIITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMD-SAQVAHW 97

Query: 85  LEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLN 144
           L+ +K+I+KQ+K G P  LH RV+F+  +PN L++E TR+L+ LQLK DI  G+L CP +
Sbjct: 98  LDGTKSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFD 157

Query: 145 SAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAE 204
           +AV LA+Y +Q+  GDY+ + H P  +S+  F+P Q E+    +    +++ G   ++AE
Sbjct: 158 TAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAE 217

Query: 205 SCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFK 264
           + Y+N A+ L+ YGV++H  +     D  +G+   GV V+        + W  I ++ FK
Sbjct: 218 TNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFK 277

Query: 265 RKK--FFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLS 322
           + K    + +   Q + +EH   F + + ++CK+LWK  VEHH FF+ +  + Q+ +  S
Sbjct: 278 KNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPV-QKSSHRS 336

Query: 323 QYWTMGSR 330
            +  +GSR
Sbjct: 337 GFIRLGSR 344


>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
          Length = 686

 Score =  196 bits (499), Expect = 6e-50
 Identities = 143/484 (29%), Positives = 225/484 (46%), Gaps = 43/484 (8%)

Query: 28  EVICSIHFLDG-----VVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSP 82
           E  C +  LD        Q   + K   G V+LD V +H+ + E +YFGL++ D S  + 
Sbjct: 10  EFYCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQT- 68

Query: 83  RWLEASKAI---RKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRL 139
            WL+ +K +   ++ +  G P TL+F ++F+  DP  L++E TR+ +FLQ+K D+ +GRL
Sbjct: 69  YWLDPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRL 128

Query: 140 TCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLK 199
            CP+N+A  L +YA+QS  GDY+   H  GY+S+  F+PDQ E+    +E +H+   G  
Sbjct: 129 PCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQI 188

Query: 200 QSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNIL 259
            SEAE  Y+  A++L+ YGV+LH     +  +  +G+   GV VY+       Y W  I 
Sbjct: 189 PSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRIT 248

Query: 260 KISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKN 319
           K+ FK  +F +    K  +  E    F   +  +CK+LWK  VEHHTFF   ++   E N
Sbjct: 249 KVHFKETQFELRVLGK--DCNETSFFFEARSKTACKHLWKCSVEHHTFF---RMPENESN 303

Query: 320 VLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVE---------HLETKSLPS 370
            L       SR   K  + +Y  +  G       M R LS++            +K+ P 
Sbjct: 304 SL-------SRKLSKFGSIRYKHRYSGRTALQ--MSRDLSIQLPRPDQNVTRSRSKTYPK 354

Query: 371 RSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVS 430
           R     P   +   R        ++ +N  NE T          ++K +      D++ S
Sbjct: 355 RIAQTQPAESNSISRIT------ANMENGENEGTIKIIAPSPVKSFKKAKNENSPDTQRS 408

Query: 431 QNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPD-GVDQQLLDDFHRVTKGGS 489
           ++ +P +    EN P        S  + SP        +P  G D   +    R     S
Sbjct: 409 KSHAPWE----ENGPQSGLYNSPSDRTKSPKFPYTRRRNPSCGSDNDSVQPVRRRKAHNS 464

Query: 490 TEDA 493
            ED+
Sbjct: 465 GEDS 468


>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
           1, RH-linked) isoform 1 [Homo sapiens]
          Length = 775

 Score =  195 bits (495), Expect = 2e-49
 Identities = 103/300 (34%), Positives = 169/300 (56%), Gaps = 6/300 (2%)

Query: 84  WLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPL 143
           WL+++K I+KQ++G  P    F V+F+ PDP  L ++ TR+   LQL+ DI  GRL C  
Sbjct: 229 WLDSAKEIKKQVRG-VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSF 287

Query: 144 NSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEA 203
            +  +L SY +QS  GDY+  +H   Y+SD    P+Q ++   KV  LH+ +  +  ++A
Sbjct: 288 ATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQA 347

Query: 204 ESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISF 263
           +  ++  A+ L  YGV+LH  +DL  +D+++G+ S+G+ VY+  +  + +PW  +LKIS+
Sbjct: 348 DLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISY 407

Query: 264 KRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQ 323
           KR  FFI  R  + E  E  + F + +YR+ K LWK CVEHHTFF   +L   +    S+
Sbjct: 408 KRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFF---RLTSTDTIPKSK 464

Query: 324 YWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPR 383
           +  +GS+  + S   Q   +    ++  PA     +     ++SL   +   + + RSPR
Sbjct: 465 FLALGSK-FRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSAD-RSPR 522


>gi|150418005 protein tyrosine phosphatase, non-receptor type 21 [Homo
            sapiens]
          Length = 1174

 Score =  194 bits (494), Expect = 2e-49
 Identities = 106/283 (37%), Positives = 166/283 (58%), Gaps = 22/283 (7%)

Query: 637  LKKGLESGTVLIQFEQLYRKK--PGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----Q 690
            L++ LE G V  ++E++ +K+   G   T A+LP+N ++NR++DVLPYD  RV L    +
Sbjct: 887  LEQRLEQGMVFTEYERILKKRLVDGECST-ARLPENAERNRFQDVLPYDDVRVELVPTKE 945

Query: 691  GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERG 750
             N  YINAS++ + +  + +   YIATQGPL +TC  FWQ+VW+Q +++I M+T   E G
Sbjct: 946  NNTGYINASHIKVSV--SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGG 1003

Query: 751  RTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYV 807
            R K  +YWP      + + +G F I  +    +  Y +  + + +  TG+E TV HLQY 
Sbjct: 1004 REKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYT 1063

Query: 808  AWPDHGVPDDSSDFLEFVNYVRSLR----------VDSEPVLVHCSAGIGRTGVLVTMET 857
             WP+HG P+D   FL ++  ++S+R            + P+LVHCSAG+GRTGV++  E 
Sbjct: 1064 DWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEI 1123

Query: 858  AMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 900
             +   E N  +    ++  +R QR M+VQT  QY FV   +++
Sbjct: 1124 MIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ 1166



 Score =  142 bits (359), Expect = 1e-33
 Identities = 126/461 (27%), Positives = 201/461 (43%), Gaps = 63/461 (13%)

Query: 25  TRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRW 84
           ++S ++  I  L+     F ++ + TGQ  L+ V   L + E  YF L + +   +  RW
Sbjct: 19  SKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQ-NQRRW 77

Query: 85  LEASKAIRKQL-KGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPL 143
           ++  K ++KQL K     T++F V F++P  + LQQE TR+ Y+LQLK DI EG + C L
Sbjct: 78  VDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTL 137

Query: 144 NSAVVLASYAVQSHFGDYNS----------SIHHPGYLSDSHFIPDQNEDFLTKVESLHE 193
             A+ LA  AVQ+ FGD++           ++   G+L D   +    E+   KV  LH+
Sbjct: 138 EQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVL----EEATQKVALLHQ 193

Query: 194 QHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAV-YRKYICTSF 252
           ++ GL   +AE  Y+     +D YG E +  +D    D+ IG    G+ V ++       
Sbjct: 194 KYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVV 253

Query: 253 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 312
           + W +I  +S  +  F +     +  ++E  + F   +  + K +W+ CV  H F++  +
Sbjct: 254 FRWHDIANMSHNKSFFAL-----ELANKEETIQFQTEDMETAKYIWRLCVARHKFYRLNQ 308

Query: 313 LLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRS 372
                 N+ +Q  T+                       NP  RRS S       SLP   
Sbjct: 309 C-----NLQTQTVTV-----------------------NPIRRRSSS-----RMSLPKPQ 335

Query: 373 PPITPNWRSPRLRHEIRKPRHSSADNL--ANEMTYITETEDVFYTYKGSLAPQDSDSEVS 430
           P + P            +P  SS DNL   N+  Y   ++      +  L  +  +  V 
Sbjct: 336 PYVMPPPPQLHYNGHYTEPYASSQDNLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVY 395

Query: 431 QNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPD 471
              S +    S NNP Q YL Q S  S +PS        PD
Sbjct: 396 SAHSTN----SLNNP-QPYL-QPSPMSSNPSITGSDVMRPD 430


>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
           [Homo sapiens]
          Length = 1045

 Score =  192 bits (488), Expect = 1e-48
 Identities = 109/309 (35%), Positives = 172/309 (55%), Gaps = 8/309 (2%)

Query: 16  RTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHD 75
           R  + P   +   V   I  LD   + F+V ++  G+VLLD V NHL + E +YFGL+  
Sbjct: 27  RGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFP 86

Query: 76  DDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDIC 135
           D    +  WL+  K I KQ++      + F V+FF PD   LQ+E TR+L+ LQ+K D+ 
Sbjct: 87  DHKKITV-WLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLA 145

Query: 136 EGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQN--EDFLTKVESLHE 193
           +GRLTC   SA +L S+ VQS  GD++ ++    +L+ + +IP Q+  ED   K+   H 
Sbjct: 146 QGRLTCNDTSAALLISHIVQSEIGDFDEALDRE-HLAKNKYIPQQDALED---KIVEFHH 201

Query: 194 QHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFY 253
            H G   +E++   + IAR L+ YG+ LH  +D     + + +A+ G+ V++ +   + +
Sbjct: 202 NHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAF 261

Query: 254 PWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQA-KK 312
            W  + K+SFKRK+F I  R     + +  + F M +   CK+ WK CVEHH FF+  ++
Sbjct: 262 NWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEE 321

Query: 313 LLPQEKNVL 321
             P+ K VL
Sbjct: 322 PKPKPKPVL 330


>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
           1 [Homo sapiens]
          Length = 518

 Score =  191 bits (485), Expect = 3e-48
 Identities = 112/348 (32%), Positives = 180/348 (51%), Gaps = 11/348 (3%)

Query: 26  RSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWL 85
           ++ + C +  LDG   +  + K   GQ L D +  HL + E +YFGLQ  D S     WL
Sbjct: 82  KATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLD-SAQVAHWL 140

Query: 86  EASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNS 145
           + +K I+KQ+K G    LHFRV+++  +PN L++E TR+L+ LQL+ DI  G+L CP  +
Sbjct: 141 DHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYET 200

Query: 146 AVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAES 205
           AV LA+  +Q+  G+     H P  +S+  FIP+Q E     +    ++  G   ++AE 
Sbjct: 201 AVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAEL 260

Query: 206 CYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKR 265
            Y+N A+ L+ YGV++H  R     +  +G+   G+ ++        + W  I K+ FK+
Sbjct: 261 SYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKK 320

Query: 266 KK--FFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQ 323
            K    + +   Q   +EH   F + + R+CK+LWK  VEHH FF+  +     K+  S 
Sbjct: 321 SKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL-RTPGNSKSNRSD 379

Query: 324 YWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSR 371
           +  +GSR  + S   +Y             +RR+ + E   +K  PSR
Sbjct: 380 FIRLGSR-FRFSGRTEY------QATHGSRLRRTSTFERKPSKRYPSR 420


>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
           2 [Homo sapiens]
          Length = 900

 Score =  191 bits (485), Expect = 3e-48
 Identities = 112/348 (32%), Positives = 180/348 (51%), Gaps = 11/348 (3%)

Query: 26  RSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWL 85
           ++ + C +  LDG   +  + K   GQ L D +  HL + E +YFGLQ  D S     WL
Sbjct: 82  KATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLD-SAQVAHWL 140

Query: 86  EASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNS 145
           + +K I+KQ+K G    LHFRV+++  +PN L++E TR+L+ LQL+ DI  G+L CP  +
Sbjct: 141 DHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYET 200

Query: 146 AVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAES 205
           AV LA+  +Q+  G+     H P  +S+  FIP+Q E     +    ++  G   ++AE 
Sbjct: 201 AVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAEL 260

Query: 206 CYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKR 265
            Y+N A+ L+ YGV++H  R     +  +G+   G+ ++        + W  I K+ FK+
Sbjct: 261 SYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKK 320

Query: 266 KK--FFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQ 323
            K    + +   Q   +EH   F + + R+CK+LWK  VEHH FF+  +     K+  S 
Sbjct: 321 SKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRL-RTPGNSKSNRSD 379

Query: 324 YWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSR 371
           +  +GSR  + S   +Y             +RR+ + E   +K  PSR
Sbjct: 380 FIRLGSR-FRFSGRTEY------QATHGSRLRRTSTFERKPSKRYPSR 420


>gi|4506291 protein tyrosine phosphatase, non-receptor type 2
           isoform 1 [Homo sapiens]
          Length = 415

 Score =  191 bits (484), Expect = 3e-48
 Identities = 101/241 (41%), Positives = 137/241 (56%), Gaps = 10/241 (4%)

Query: 665 AKLPQNLDKNRYKDVLPYDTTRVLLQGNE-DYINASYVNMEIPAANLVNKYIATQGPLPH 723
           AK P+N ++NRY+DV PYD +RV LQ  E DYINAS V++E         YI TQGPLP+
Sbjct: 37  AKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIE----EAQRSYILTQGPLPN 92

Query: 724 TCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP--DPPDVMNHGGFHIQCQSEDCTI 781
           TC  FW +VW QK   +VML  + E+   KC QYWP  D   +    GF ++  SED   
Sbjct: 93  TCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKS 152

Query: 782 AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPV 838
            Y    + + N  +GE  T++H  Y  WPD GVP+  + FL F+  VR   SL  D  P 
Sbjct: 153 YYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPA 212

Query: 839 LVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAI 898
           ++HCSAGIGR+G    ++T + L E+   I    ++  MR  R  ++QT  Q +F   AI
Sbjct: 213 VIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAI 272

Query: 899 L 899
           +
Sbjct: 273 I 273


>gi|18104982 protein tyrosine phosphatase, non-receptor type 2 [Homo
           sapiens]
          Length = 353

 Score =  191 bits (484), Expect = 3e-48
 Identities = 101/241 (41%), Positives = 137/241 (56%), Gaps = 10/241 (4%)

Query: 665 AKLPQNLDKNRYKDVLPYDTTRVLLQGNE-DYINASYVNMEIPAANLVNKYIATQGPLPH 723
           AK P+N ++NRY+DV PYD +RV LQ  E DYINAS V++E         YI TQGPLP+
Sbjct: 37  AKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIE----EAQRSYILTQGPLPN 92

Query: 724 TCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP--DPPDVMNHGGFHIQCQSEDCTI 781
           TC  FW +VW QK   +VML  + E+   KC QYWP  D   +    GF ++  SED   
Sbjct: 93  TCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKS 152

Query: 782 AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPV 838
            Y    + + N  +GE  T++H  Y  WPD GVP+  + FL F+  VR   SL  D  P 
Sbjct: 153 YYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPA 212

Query: 839 LVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAI 898
           ++HCSAGIGR+G    ++T + L E+   I    ++  MR  R  ++QT  Q +F   AI
Sbjct: 213 VIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAI 272

Query: 899 L 899
           +
Sbjct: 273 I 273


>gi|18104980 protein tyrosine phosphatase, non-receptor type 2
           isoform 2 [Homo sapiens]
          Length = 387

 Score =  191 bits (484), Expect = 3e-48
 Identities = 101/241 (41%), Positives = 137/241 (56%), Gaps = 10/241 (4%)

Query: 665 AKLPQNLDKNRYKDVLPYDTTRVLLQGNE-DYINASYVNMEIPAANLVNKYIATQGPLPH 723
           AK P+N ++NRY+DV PYD +RV LQ  E DYINAS V++E         YI TQGPLP+
Sbjct: 37  AKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIE----EAQRSYILTQGPLPN 92

Query: 724 TCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP--DPPDVMNHGGFHIQCQSEDCTI 781
           TC  FW +VW QK   +VML  + E+   KC QYWP  D   +    GF ++  SED   
Sbjct: 93  TCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKS 152

Query: 782 AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPV 838
            Y    + + N  +GE  T++H  Y  WPD GVP+  + FL F+  VR   SL  D  P 
Sbjct: 153 YYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPA 212

Query: 839 LVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAI 898
           ++HCSAGIGR+G    ++T + L E+   I    ++  MR  R  ++QT  Q +F   AI
Sbjct: 213 VIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAI 272

Query: 899 L 899
           +
Sbjct: 273 I 273


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
            isoform 4 [Homo sapiens]
          Length = 2490

 Score =  190 bits (482), Expect = 6e-48
 Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)

Query: 605  FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 664
            F + DEL  L    + P     G  L+  +  L+  L+ G    + E L   KP      
Sbjct: 2177 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2236

Query: 665  AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 724
             +  +N  KNRYK++LPYD TRV L     YINAS++ + +     V  YIA QGPLP T
Sbjct: 2237 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2294

Query: 725  CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 782
               FWQ++W+QK ++I M+T   E  + KC +YWP+      M      +          
Sbjct: 2295 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2354

Query: 783  YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 842
            +V R M + + QT E   ++HL + AWPDH  P    D L F++Y+R +   S P++ HC
Sbjct: 2355 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2413

Query: 843  SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 901
            SAGIGR+G L+ ++  + L  ++L     D+VR MR QR  MVQT  QY F  + IL V
Sbjct: 2414 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2472



 Score =  119 bits (298), Expect = 1e-26
 Identities = 132/593 (22%), Positives = 238/593 (40%), Gaps = 82/593 (13%)

Query: 54   LLDMVHNHLGVTEKEYFGLQHDDDS-------------VDSPRWLEASKAIRKQLKGGFP 100
            + DMV  H+G+ E   F L    D+             V    W E  K   K+ K    
Sbjct: 597  VFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPK---KKTKATVN 653

Query: 101  CTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGD 160
             TL FR++FF+ D + +Q   T H Y+LQL+ DI E R+ C   ++++LAS A+Q+ +GD
Sbjct: 654  FTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGD 713

Query: 161  YNSSIHHPGYLSDSHFIPDQNEDFL------TKVESLHEQHSGLKQSEAESCYINIARTL 214
            Y   +H   Y    H++P +  + L       ++  LH  + G  + E E  ++ + + L
Sbjct: 714  YQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRL 773

Query: 215  DFYGVELH--SGRDLHNLDLMIGIASAGVAVYRKY----ICTSFYPWVNILKISFKRKKF 268
              YGV  H           +++G+ S GV V+  +         +PW    KISF +KK 
Sbjct: 774  TEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKI 833

Query: 269  FIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTF---FQAKKLLPQEKNVLSQYW 325
             +   Q  ++  +H   F   N + C+ L   C   H F    +A++     +++     
Sbjct: 834  TL---QNTSDGIKH--GFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDI----- 883

Query: 326  TMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLR 385
                R + +S+N Q  + V G  +       SL+   L   ++   S       R     
Sbjct: 884  ---ERASFRSLNLQ-AESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQAEILKRLSCSE 939

Query: 386  HEIRKPRHSSADNLANEMTYITETEDVFYTY----KGSLAPQDSDSEVSQNRSP------ 435
              + +P  +S+    ++ ++  +  ++  +Y    + SL P   +  V+    P      
Sbjct: 940  LSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAEL 999

Query: 436  -----HQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHR----VTK 486
                 HQ S S+           +S SV+  + +P     +     + D        +T 
Sbjct: 1000 VGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTM 1059

Query: 487  GGSTEDASQYYCDKND----------NGDSYLVLIRITPDEDGKFGFNLKGGVDQ---KM 533
              S   +SQ    +ND          + +  + L+ +  D     GF + GG       +
Sbjct: 1060 HSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDL 1119

Query: 534  PLVVSRINPESPADT--CIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRE 584
             + +S + P  PAD   C   L  GD+++ +N   +   +H   +  ++ + E
Sbjct: 1120 GIFISSVAPGGPADLDGC---LKPGDRLISVNSVSLEGVSHHAAIEILQNAPE 1169



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 58/269 (21%), Positives = 108/269 (40%), Gaps = 30/269 (11%)

Query: 351  NPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKP--RHSSADNLAN-EMTYIT 407
            +PA     S +     S   +S     N  S + + + + P  R S +D+  + E   +T
Sbjct: 1611 SPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVT 1670

Query: 408  ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSS 456
               ++  +   S   Q   + VSQ +S H+   S+ +      Y  QK         S+ 
Sbjct: 1671 APANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNP 1730

Query: 457  SVSPSSNAPGSC---SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV-- 509
            S  P   APG       +      +D +H   +++    E+ +    D  ++ + + +  
Sbjct: 1731 SPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEV 1790

Query: 510  --LIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDI 567
              LI +   E G  GF +  G  +    V   I   + +D    +L  GD+++ +N  D+
Sbjct: 1791 ELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDV 1847

Query: 568  SEHTHDQVVMFIKASRESHSRELALVIRR 596
            +  TH   V  ++A+    S+ + LVI R
Sbjct: 1848 TNMTHTDAVNLLRAA----SKTVRLVIGR 1872


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
            isoform 3 [Homo sapiens]
          Length = 2294

 Score =  190 bits (482), Expect = 6e-48
 Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)

Query: 605  FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 664
            F + DEL  L    + P     G  L+  +  L+  L+ G    + E L   KP      
Sbjct: 1981 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2040

Query: 665  AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 724
             +  +N  KNRYK++LPYD TRV L     YINAS++ + +     V  YIA QGPLP T
Sbjct: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2098

Query: 725  CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 782
               FWQ++W+QK ++I M+T   E  + KC +YWP+      M      +          
Sbjct: 2099 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2158

Query: 783  YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 842
            +V R M + + QT E   ++HL + AWPDH  P    D L F++Y+R +   S P++ HC
Sbjct: 2159 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2217

Query: 843  SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 901
            SAGIGR+G L+ ++  + L  ++L     D+VR MR QR  MVQT  QY F  + IL V
Sbjct: 2218 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2276



 Score =  114 bits (285), Expect = 4e-25
 Identities = 90/332 (27%), Positives = 145/332 (43%), Gaps = 46/332 (13%)

Query: 54  LLDMVHNHLGVTEKEYFGLQHDDDS-------------VDSPRWLEASKAIRKQLKGGFP 100
           + DMV  H+G+ E   F L    D+             V    W E  K   K+ K    
Sbjct: 597 VFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPK---KKTKATVN 653

Query: 101 CTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGD 160
            TL FR++FF+ D + +Q   T H Y+LQL+ DI E R+ C   ++++LAS A+Q+ +GD
Sbjct: 654 FTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGD 713

Query: 161 YNSSIHHPGYLSDSHFIPDQNEDFL------TKVESLHEQHSGLKQSEAESCYINIARTL 214
           Y   +H   Y    H++P +  + L       ++  LH  + G  + E E  ++ + + L
Sbjct: 714 YQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRL 773

Query: 215 DFYGVELH--SGRDLHNLDLMIGIASAGVAVYRKY----ICTSFYPWVNILKISFKRKKF 268
             YGV  H           +++G+ S GV V+  +         +PW    KISF +KK 
Sbjct: 774 TEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKI 833

Query: 269 FIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTF-----FQAKKLLPQEKNVLSQ 323
            +   Q  ++  +H   F   N + C+ L   C   H F      +      Q+ +VL +
Sbjct: 834 TL---QNTSDGIKH--GFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIDVLHK 888

Query: 324 YWTMGSR--------NTKKSVNNQYCKKVIGG 347
            W++ S         N KK        ++IGG
Sbjct: 889 RWSIVSSPEREITLVNLKKDAKYGLGFQIIGG 920



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 58/269 (21%), Positives = 108/269 (40%), Gaps = 30/269 (11%)

Query: 351  NPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKP--RHSSADNLAN-EMTYIT 407
            +PA     S +     S   +S     N  S + + + + P  R S +D+  + E   +T
Sbjct: 1415 SPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVT 1474

Query: 408  ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSS 456
               ++  +   S   Q   + VSQ +S H+   S+ +      Y  QK         S+ 
Sbjct: 1475 APANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNP 1534

Query: 457  SVSPSSNAPGSC---SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV-- 509
            S  P   APG       +      +D +H   +++    E+ +    D  ++ + + +  
Sbjct: 1535 SPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEV 1594

Query: 510  --LIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDI 567
              LI +   E G  GF +  G  +    V   I   + +D    +L  GD+++ +N  D+
Sbjct: 1595 ELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDV 1651

Query: 568  SEHTHDQVVMFIKASRESHSRELALVIRR 596
            +  TH   V  ++A+    S+ + LVI R
Sbjct: 1652 TNMTHTDAVNLLRAA----SKTVRLVIGR 1676



 Score = 31.2 bits (69), Expect = 4.6
 Identities = 16/62 (25%), Positives = 34/62 (54%), Gaps = 4/62 (6%)

Query: 518  DGKFGFNLKGGVDQKMP---LVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQ 574
            D   G ++ GGV+  +    + V  + P+  A++   ++++GD+++ +NG  +   TH Q
Sbjct: 1184 DNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESD-GRIHKGDRVLAVNGVSLEGATHKQ 1242

Query: 575  VV 576
             V
Sbjct: 1243 AV 1244


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
            isoform 1 [Homo sapiens]
          Length = 2485

 Score =  190 bits (482), Expect = 6e-48
 Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)

Query: 605  FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 664
            F + DEL  L    + P     G  L+  +  L+  L+ G    + E L   KP      
Sbjct: 2172 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2231

Query: 665  AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 724
             +  +N  KNRYK++LPYD TRV L     YINAS++ + +     V  YIA QGPLP T
Sbjct: 2232 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2289

Query: 725  CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 782
               FWQ++W+QK ++I M+T   E  + KC +YWP+      M      +          
Sbjct: 2290 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2349

Query: 783  YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 842
            +V R M + + QT E   ++HL + AWPDH  P    D L F++Y+R +   S P++ HC
Sbjct: 2350 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2408

Query: 843  SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 901
            SAGIGR+G L+ ++  + L  ++L     D+VR MR QR  MVQT  QY F  + IL V
Sbjct: 2409 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2467



 Score =  119 bits (298), Expect = 1e-26
 Identities = 132/593 (22%), Positives = 238/593 (40%), Gaps = 82/593 (13%)

Query: 54   LLDMVHNHLGVTEKEYFGLQHDDDS-------------VDSPRWLEASKAIRKQLKGGFP 100
            + DMV  H+G+ E   F L    D+             V    W E  K   K+ K    
Sbjct: 597  VFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPK---KKTKATVN 653

Query: 101  CTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGD 160
             TL FR++FF+ D + +Q   T H Y+LQL+ DI E R+ C   ++++LAS A+Q+ +GD
Sbjct: 654  FTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGD 713

Query: 161  YNSSIHHPGYLSDSHFIPDQNEDFL------TKVESLHEQHSGLKQSEAESCYINIARTL 214
            Y   +H   Y    H++P +  + L       ++  LH  + G  + E E  ++ + + L
Sbjct: 714  YQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRL 773

Query: 215  DFYGVELH--SGRDLHNLDLMIGIASAGVAVYRKY----ICTSFYPWVNILKISFKRKKF 268
              YGV  H           +++G+ S GV V+  +         +PW    KISF +KK 
Sbjct: 774  TEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKI 833

Query: 269  FIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTF---FQAKKLLPQEKNVLSQYW 325
             +   Q  ++  +H   F   N + C+ L   C   H F    +A++     +++     
Sbjct: 834  TL---QNTSDGIKH--GFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDI----- 883

Query: 326  TMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLR 385
                R + +S+N Q  + V G  +       SL+   L   ++   S       R     
Sbjct: 884  ---ERASFRSLNLQ-AESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQAEILKRLSCSE 939

Query: 386  HEIRKPRHSSADNLANEMTYITETEDVFYTY----KGSLAPQDSDSEVSQNRSP------ 435
              + +P  +S+    ++ ++  +  ++  +Y    + SL P   +  V+    P      
Sbjct: 940  LSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAEL 999

Query: 436  -----HQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHR----VTK 486
                 HQ S S+           +S SV+  + +P     +     + D        +T 
Sbjct: 1000 VGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTM 1059

Query: 487  GGSTEDASQYYCDKND----------NGDSYLVLIRITPDEDGKFGFNLKGGVDQ---KM 533
              S   +SQ    +ND          + +  + L+ +  D     GF + GG       +
Sbjct: 1060 HSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDL 1119

Query: 534  PLVVSRINPESPADT--CIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRE 584
             + +S + P  PAD   C   L  GD+++ +N   +   +H   +  ++ + E
Sbjct: 1120 GIFISSVAPGGPADLDGC---LKPGDRLISVNSVSLEGVSHHAAIEILQNAPE 1169



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 58/269 (21%), Positives = 108/269 (40%), Gaps = 30/269 (11%)

Query: 351  NPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKP--RHSSADNLAN-EMTYIT 407
            +PA     S +     S   +S     N  S + + + + P  R S +D+  + E   +T
Sbjct: 1606 SPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVT 1665

Query: 408  ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSS 456
               ++  +   S   Q   + VSQ +S H+   S+ +      Y  QK         S+ 
Sbjct: 1666 APANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNP 1725

Query: 457  SVSPSSNAPGSC---SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV-- 509
            S  P   APG       +      +D +H   +++    E+ +    D  ++ + + +  
Sbjct: 1726 SPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEV 1785

Query: 510  --LIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDI 567
              LI +   E G  GF +  G  +    V   I   + +D    +L  GD+++ +N  D+
Sbjct: 1786 ELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDV 1842

Query: 568  SEHTHDQVVMFIKASRESHSRELALVIRR 596
            +  TH   V  ++A+    S+ + LVI R
Sbjct: 1843 TNMTHTDAVNLLRAA----SKTVRLVIGR 1867



 Score = 31.2 bits (69), Expect = 4.6
 Identities = 16/62 (25%), Positives = 34/62 (54%), Gaps = 4/62 (6%)

Query: 518  DGKFGFNLKGGVDQKMP---LVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQ 574
            D   G ++ GGV+  +    + V  + P+  A++   ++++GD+++ +NG  +   TH Q
Sbjct: 1375 DNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESD-GRIHKGDRVLAVNGVSLEGATHKQ 1433

Query: 575  VV 576
             V
Sbjct: 1434 AV 1435


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
            2 [Homo sapiens]
          Length = 2466

 Score =  190 bits (482), Expect = 6e-48
 Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)

Query: 605  FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 664
            F + DEL  L    + P     G  L+  +  L+  L+ G    + E L   KP      
Sbjct: 2153 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2212

Query: 665  AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 724
             +  +N  KNRYK++LPYD TRV L     YINAS++ + +     V  YIA QGPLP T
Sbjct: 2213 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2270

Query: 725  CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 782
               FWQ++W+QK ++I M+T   E  + KC +YWP+      M      +          
Sbjct: 2271 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2330

Query: 783  YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 842
            +V R M + + QT E   ++HL + AWPDH  P    D L F++Y+R +   S P++ HC
Sbjct: 2331 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2389

Query: 843  SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 901
            SAGIGR+G L+ ++  + L  ++L     D+VR MR QR  MVQT  QY F  + IL V
Sbjct: 2390 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2448



 Score =  116 bits (290), Expect = 1e-25
 Identities = 127/576 (22%), Positives = 236/576 (40%), Gaps = 67/576 (11%)

Query: 54   LLDMVHNHLGVTEKEYFGLQHDDDS-------------VDSPRWLEASKAIRKQLKGGFP 100
            + DMV  H+G+ E   F L    D+             V    W E  K   K+ K    
Sbjct: 597  VFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPK---KKTKATVN 653

Query: 101  CTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGD 160
             TL FR++FF+ D + +Q   T H Y+LQL+ DI E R+ C   ++++LAS A+Q+ +GD
Sbjct: 654  FTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGD 713

Query: 161  YNSSIHHPGYLSDSHFIPDQNEDFL------TKVESLHEQHSGLKQSEAESCYINIARTL 214
            Y   +H   Y    H++P +  + L       ++  LH  + G  + E E  ++ + + L
Sbjct: 714  YQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRL 773

Query: 215  DFYGVELH--SGRDLHNLDLMIGIASAGVAVYRKY----ICTSFYPWVNILKISFKRKKF 268
              YGV  H           +++G+ S GV V+  +         +PW    KISF +KK 
Sbjct: 774  TEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKI 833

Query: 269  FIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTF---FQAKKLLPQEKNVLSQYW 325
             +   Q  ++  +H   F   N + C+ L   C   H F    +A++     +++     
Sbjct: 834  TL---QNTSDGIKH--GFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDI----- 883

Query: 326  TMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLR 385
                R + +S+N Q  + V G  +       SL+   L   ++   S       R     
Sbjct: 884  ---ERASFRSLNLQ-AESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQAEILKRLSCSE 939

Query: 386  HEIRKPRHSSADNLANEMTYITETEDVFYTY----KGSLAPQDSDSEVSQNRSPHQESLS 441
              + +P  +S+    ++ ++  +  ++  +Y    + SL P   +  V+    P   +  
Sbjct: 940  LSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAEL 999

Query: 442  ENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYC--- 498
               P+   +++  + S++  +    S S   +++      H  +   S ED  Q Y    
Sbjct: 1000 VGKPSHQ-MSRSDAESLAGVTKLNNSKSVASLNRSPERRKHE-SDSSSIEDPGQAYVLDV 1057

Query: 499  -----DKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQ---KMPLVVSRINPESPADT-- 548
                     + +  + L+ +  D     GF + GG       + + +S + P  PAD   
Sbjct: 1058 LHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDG 1117

Query: 549  CIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRE 584
            C   L  GD+++ +N   +   +H   +  ++ + E
Sbjct: 1118 C---LKPGDRLISVNSVSLEGVSHHAAIEILQNAPE 1150



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 58/269 (21%), Positives = 108/269 (40%), Gaps = 30/269 (11%)

Query: 351  NPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKP--RHSSADNLAN-EMTYIT 407
            +PA     S +     S   +S     N  S + + + + P  R S +D+  + E   +T
Sbjct: 1587 SPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVT 1646

Query: 408  ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSS 456
               ++  +   S   Q   + VSQ +S H+   S+ +      Y  QK         S+ 
Sbjct: 1647 APANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNP 1706

Query: 457  SVSPSSNAPGSC---SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV-- 509
            S  P   APG       +      +D +H   +++    E+ +    D  ++ + + +  
Sbjct: 1707 SPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEV 1766

Query: 510  --LIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDI 567
              LI +   E G  GF +  G  +    V   I   + +D    +L  GD+++ +N  D+
Sbjct: 1767 ELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDV 1823

Query: 568  SEHTHDQVVMFIKASRESHSRELALVIRR 596
            +  TH   V  ++A+    S+ + LVI R
Sbjct: 1824 TNMTHTDAVNLLRAA----SKTVRLVIGR 1848



 Score = 31.2 bits (69), Expect = 4.6
 Identities = 16/62 (25%), Positives = 34/62 (54%), Gaps = 4/62 (6%)

Query: 518  DGKFGFNLKGGVDQKMP---LVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQ 574
            D   G ++ GGV+  +    + V  + P+  A++   ++++GD+++ +NG  +   TH Q
Sbjct: 1356 DNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESD-GRIHKGDRVLAVNGVSLEGATHKQ 1414

Query: 575  VV 576
             V
Sbjct: 1415 AV 1416


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,482,359
Number of Sequences: 37866
Number of extensions: 1626702
Number of successful extensions: 5589
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 4596
Number of HSP's gapped (non-prelim): 524
length of query: 913
length of database: 18,247,518
effective HSP length: 111
effective length of query: 802
effective length of database: 14,044,392
effective search space: 11263602384
effective search space used: 11263602384
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.