Search of human proteins with 222446607

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
         (729 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]      1463   0.0  
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]        370   e-102
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]       361   1e-99
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s...   115   1e-25
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ...   111   3e-24
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s...   111   3e-24
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s...   105   1e-22
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]                91   5e-18
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                91   5e-18
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ...    82   1e-15
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ...    82   1e-15
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ...    82   1e-15
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ...    82   1e-15
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ...    82   1e-15
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ...    82   1e-15
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s...    82   1e-15
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ...    82   1e-15
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s...    80   5e-15
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]         80   7e-15
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]         80   7e-15
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]         80   7e-15
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa...    80   9e-15
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s...    80   9e-15
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    80   9e-15
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    80   9e-15
gi|194294525 intersectin 2 isoform 2 [Homo sapiens]                    80   9e-15
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s...    79   1e-14
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s...    79   1e-14
gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens]                       69   1e-11
gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens]                     66   1e-10

>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
          Length = 729

 Score = 1463 bits (3788), Expect = 0.0
 Identities = 729/729 (100%), Positives = 729/729 (100%)

Query: 1   MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRVFKAHKELRCPECRTPVFSNI 60
           MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRVFKAHKELRCPECRTPVFSNI
Sbjct: 1   MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRVFKAHKELRCPECRTPVFSNI 60

Query: 61  EALPANLLLVRLLDGVRSGQSSGRGGSFRRPGTMTLQDGRKSRTNPRRLQASPFRLVPNV 120
           EALPANLLLVRLLDGVRSGQSSGRGGSFRRPGTMTLQDGRKSRTNPRRLQASPFRLVPNV
Sbjct: 61  EALPANLLLVRLLDGVRSGQSSGRGGSFRRPGTMTLQDGRKSRTNPRRLQASPFRLVPNV 120

Query: 121 RIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVE 180
           RIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVE
Sbjct: 121 RIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVE 180

Query: 181 VIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVG 240
           VIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVG
Sbjct: 181 VIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVG 240

Query: 241 IFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPGQFS 300
           IFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPGQFS
Sbjct: 241 IFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPGQFS 300

Query: 301 ITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVGQVSTYHPA 360
           ITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVGQVSTYHPA
Sbjct: 301 ITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVGQVSTYHPA 360

Query: 361 PVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRG 420
           PVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRG
Sbjct: 361 PVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRG 420

Query: 421 VSLVTGRVGIFPNNYVIPIFRKTSSFPDSRSPGLYTTWTLSTSSVSSQGSISEGDPRQSR 480
           VSLVTGRVGIFPNNYVIPIFRKTSSFPDSRSPGLYTTWTLSTSSVSSQGSISEGDPRQSR
Sbjct: 421 VSLVTGRVGIFPNNYVIPIFRKTSSFPDSRSPGLYTTWTLSTSSVSSQGSISEGDPRQSR 480

Query: 481 PFKSVFVPTAIVNPVRSTAGPGTLGQGSLRKGRSSMRKNGSLQRPLQSGIPTLVVGSLRR 540
           PFKSVFVPTAIVNPVRSTAGPGTLGQGSLRKGRSSMRKNGSLQRPLQSGIPTLVVGSLRR
Sbjct: 481 PFKSVFVPTAIVNPVRSTAGPGTLGQGSLRKGRSSMRKNGSLQRPLQSGIPTLVVGSLRR 540

Query: 541 SPTMVLRPQQFQFYQPQGIPSSPSAVVVEMGSKPALTGEPALTCISRGSEARIHSAASSL 600
           SPTMVLRPQQFQFYQPQGIPSSPSAVVVEMGSKPALTGEPALTCISRGSEARIHSAASSL
Sbjct: 541 SPTMVLRPQQFQFYQPQGIPSSPSAVVVEMGSKPALTGEPALTCISRGSEARIHSAASSL 600

Query: 601 IMEDKEIPIKSEPLPKPPASAPPSILVKPENSRNGIEKQVKTVRFQNYSPPPTKHYTSHP 660
           IMEDKEIPIKSEPLPKPPASAPPSILVKPENSRNGIEKQVKTVRFQNYSPPPTKHYTSHP
Sbjct: 601 IMEDKEIPIKSEPLPKPPASAPPSILVKPENSRNGIEKQVKTVRFQNYSPPPTKHYTSHP 660

Query: 661 TSGKPEQPATLKASQPEAASLGPEMTVLFAHRSGCHSGQQTDLRRKSALGKATTLVSTAS 720
           TSGKPEQPATLKASQPEAASLGPEMTVLFAHRSGCHSGQQTDLRRKSALGKATTLVSTAS
Sbjct: 661 TSGKPEQPATLKASQPEAASLGPEMTVLFAHRSGCHSGQQTDLRRKSALGKATTLVSTAS 720

Query: 721 GTQTVFPSK 729
           GTQTVFPSK
Sbjct: 721 GTQTVFPSK 729


>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
          Length = 888

 Score =  370 bits (950), Expect = e-102
 Identities = 270/815 (33%), Positives = 386/815 (47%), Gaps = 103/815 (12%)

Query: 1   MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRVFKAHKELRCPECRTPVFSNI 60
           MD+  LLDLLECPVC E+LD +AKVLPCQHTFCK CL  +  +  ELRCPECRT V S +
Sbjct: 1   MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGV 60

Query: 61  EALPANLLLVRLLDGVRSGQ---SSGRGGSFRRPGTMTLQDGRKSRTNPRRLQASPFRLV 117
           E LP+N+LLVRLLDG++        G G        +  Q    +  + + LQ+S     
Sbjct: 61  EELPSNILLVRLLDGIKQRPWKPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQ 120

Query: 118 PNVRIH---MDGVPR---AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS 171
           P V+     + G+P+   AKAL NY G+ PGDL+F+KGDII+LRRQ+DENWY GE+NGI 
Sbjct: 121 PRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH 180

Query: 172 GNFPASSVEVIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWA 231
           G FP + V++IK LPQPPP C+ALY+F++  KDK  ++DCL F KDD++TVI RVDENWA
Sbjct: 181 GFFPTNFVQIIKPLPQPPPQCKALYDFEV--KDKEADKDCLPFAKDDVLTVIRRVDENWA 238

Query: 232 EGKLGDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGS 291
           EG L DK+GIFPI +VE N  A+ L+E +K              SS+   +ST  +   +
Sbjct: 239 EGMLADKIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAG---ECSSAAAQSSTAPKHSDT 295

Query: 292 RRKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPS---------------- 335
           ++    + S  T+L   N+   +   RH +EIS PVLISSSNP+                
Sbjct: 296 KKNTKKRHSF-TSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAP 354

Query: 336 ----------VITQPMEK-----------ADVP-SSCVGQVSTYHPAP----------VS 363
                     ++T P              +DVP  + +G ++   P P            
Sbjct: 355 SQVHISTTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTP 414

Query: 364 PGHSTAVVS-------LPGSQQHLS-------ANMFVALHSYSAHGPDELDLQKGEGVRV 409
           PG + A  +       + GS   ++        +++VA++ Y+    DEL+L+KGE   V
Sbjct: 415 PGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLV 474

Query: 410 LGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSSFPDSRSPGLYTTWTLSTSSVSSQG 469
             +CQDGW +G S+ T ++G+FP NYV P+ R  ++   ++ P   +T   ++  V+   
Sbjct: 475 FERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVP--MSTAGQTSRGVTMVS 532

Query: 470 SISEGDPRQSRPFKSV-----FVPTAIVNPVRSTAGPGT------LGQGSLRKGRSSMRK 518
             + G P Q      V      VP A+V+       P         GQ ++ + R+++R 
Sbjct: 533 PSTAGGPAQKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRT 592

Query: 519 NG--SLQRPLQSGIPTLVVGSLRRSPTMVLRPQQFQFYQPQGIPSSPSAVVVEMGSKPAL 576
               + +RP  +  P  V  +   SP  V          PQ  P  P +         + 
Sbjct: 593 VAAHNQERPTAAVTPIQVQNAAGLSPASV-GLSHHSLASPQPAPLMPGSATHTAAISISR 651

Query: 577 TGEPALTCISRGSEARIHSAASSLIMEDKEIPIKSEP-LPKPPASAPPSILVKPENSRNG 635
              P L C +          ++SL  E     +   P LP  P SA  +         + 
Sbjct: 652 ASAP-LACAAAAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDK 710

Query: 636 IEKQVKTVRFQNYSPPPTKHYTSHPTSGKPEQPATL-KASQPEAASLGPEMTVLFAHRSG 694
             K+ K    +  S   TK          P     L  A  P   ++GPE+     H   
Sbjct: 711 DSKKEKKGLLKLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPPGGGHGRA 770

Query: 695 CHSGQQTDLRRKSALGKATTLVSTASGTQTVFPSK 729
                  D       G  TT V+ A+  Q  F  K
Sbjct: 771 GSCPVDGD-------GPVTTAVAGAALAQDAFHRK 798



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 18/56 (32%), Positives = 34/56 (60%), Gaps = 2/56 (3%)

Query: 129 RAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEI--NGISGNFPASSVEVI 182
           R + + +Y  Q+  +L   +GDI+ + ++ ++ W++G +  NG +G FP S VE I
Sbjct: 833 RHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 18/47 (38%), Positives = 28/47 (59%)

Query: 390 SYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           SY      EL+L++G+ V V  K +DGW +G     G+ G+FP ++V
Sbjct: 839 SYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFV 885


>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
          Length = 882

 Score =  361 bits (927), Expect = 1e-99
 Identities = 258/755 (34%), Positives = 371/755 (49%), Gaps = 94/755 (12%)

Query: 1   MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRVFKAHKELRCPECRTPVFSNI 60
           MD+ +LLDLLEC VC E+LD TAKVLPCQHTFC+ CL+ +  +  ELRCPECR  V   +
Sbjct: 46  MDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGV 105

Query: 61  EALPANLLLVRLLDGVRS------------------GQSS-------GRGGSFRRPGTMT 95
           + LPAN+LLVRLLDG+R                   GQS+       G G +   PG+  
Sbjct: 106 DELPANILLVRLLDGIRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPV 165

Query: 96  LQDGRKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLR 155
                   T     + +  R  P  + +   +P  KAL +Y G+ PGDL+FNKGDII+LR
Sbjct: 166 FLSAAAGSTAGSLRELATSRTAPAAK-NPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLR 224

Query: 156 RQLDENWYQGEINGISGNFPASSVEVIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFL 215
           R++DE WY GE++G  G  PAS ++ I+ LP  PP  +ALY+F++  KDK +++DCLTF 
Sbjct: 225 RKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPPQGKALYDFEM--KDKDQDKDCLTFT 282

Query: 216 KDDIITVISRVDENWAEGKLGDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTK-NLSLV 274
           KD+I+TV+ RVDENWAEG LGDK+GIFP+L+VE N +A+ L+E +K   ++ +  N SL 
Sbjct: 283 KDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLP 342

Query: 275 SS-------------SSRGNTSTLRRGPGSRRKVPGQFSITTALNTLNRMVHSPSGRHMV 321
           S              SS G  S  +R    ++    + S  TAL+  +R   + S RH +
Sbjct: 343 SDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSF-TALSVTHRSSQAASHRHSM 401

Query: 322 EISTPVLISSSNPSVITQPMEKADV----PSSCVGQVSTYHPAPVSPGHSTAVVSLPGSQ 377
           EIS PVLISSS+P    +  + A +    P+  V   +   P  V    S +       +
Sbjct: 402 EISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPK 461

Query: 378 QHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVI 437
             L  N+++AL++Y     DEL+L KGE  RVL KCQDGW +G SL TG  G+FP NYV 
Sbjct: 462 VQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVT 521

Query: 438 PIFRKTSSFP----------DSRSPGLYTTWTLSTSSVSSQGSISEGDPRQSRPFKSVFV 487
           P+ R  +                + G+ TT    + S+SS  +        +RP   +  
Sbjct: 522 PVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLAT-------ATRPALPITT 574

Query: 488 PTAIVNPVRSTAGPGTLGQGSLRKGRSSMRKNGSL---------QRPLQSGIPTLVVGSL 538
           P A      ++   G+  + S +   S  R   S           RP  +  P     S 
Sbjct: 575 PQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSP 634

Query: 539 RRSPTMVLRPQQFQFYQPQGIPSSPSAVVVEMGSKPALTGEPALTCIS--RGSEARIHSA 596
            R P   LRP       PQ     P    V+M  +PA+    A + I+    S A ++  
Sbjct: 635 SRLPATSLRPH--SVVSPQHSHQPP----VQMCPRPAIPLTSAASAITPPNVSAANLNGE 688

Query: 597 ASSLIMEDKEIPIKSEPLPKPPASAPPSILVKPENSRNGIEKQVKTVRFQNYSPPPTKHY 656
           A               P+     S+P +   K +  ++  +K+ K+   +  +   TK  
Sbjct: 689 AG------------GGPIGVLSTSSPTNTGCKLDEKKSE-KKEKKSGLLKLLAGASTKKK 735

Query: 657 TSHPTSGKPEQPATLKASQPEAASLGPEMTVLFAH 691
           +  P S  P     +        ++GPE++ L  H
Sbjct: 736 SRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIH 770



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 26/96 (27%), Positives = 48/96 (50%), Gaps = 12/96 (12%)

Query: 89  RRPGTMTLQDGRKSRTNPRRLQASPFRLVPNVRIHMDGVPRAK--ALCNYRGQNPGDLRF 146
           R+ G++ L     SR  P  + A        +R     +PR +   + +Y  Q+  ++  
Sbjct: 793 RKAGSLDLNFTSPSRQAPLSMAA--------IRPEPKLLPRERYRVVVSYPPQSEAEIEL 844

Query: 147 NKGDIILLRRQLDENWYQGEI--NGISGNFPASSVE 180
            +GDI+ + ++ ++ WY+G +  NG +G FP S VE
Sbjct: 845 KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 18/47 (38%), Positives = 28/47 (59%)

Query: 390 SYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           SY      E++L++G+ V V  K +DGW +G     GR G+FP ++V
Sbjct: 833 SYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFV 879


>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
            sapiens]
          Length = 1151

 Score =  115 bits (288), Expect = 1e-25
 Identities = 92/342 (26%), Positives = 155/342 (45%), Gaps = 42/342 (12%)

Query: 130  AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIK--QLPQ 187
            A+A  +++ Q   +L   KGDI+ + +Q+D+NWY+GE +G  G FP + +E++   +  Q
Sbjct: 820  ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 879

Query: 188  PPPLC--------RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLG--D 237
            P  L          A+  F+  G  + E    ++F K + IT++ +VDENW EG++    
Sbjct: 880  PKKLTPVQVLEYGEAIAKFNFNGDTQVE----MSFRKGERITLLRQVDENWYEGRIPGTS 935

Query: 238  KVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTST------------- 284
            + GIFPI +V+       ++++   +      +L   SS SR  T++             
Sbjct: 936  RQGIFPITYVD-------VIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYER 988

Query: 285  -LRRGPGSRRKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEK 343
               RG G R     + S  + L   + +    + + + +++TP       P     P  +
Sbjct: 989  KAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSE 1048

Query: 344  ADVPS-----SCVGQVSTYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDE 398
            A+           G+ +        P      V+   SQ       + AL+SY     DE
Sbjct: 1049 AEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDE 1108

Query: 399  LDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIF 440
            L+L+ G+ V V+ KC DGW  G S  T + G FP NYV P++
Sbjct: 1109 LELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 1150



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 18/56 (32%), Positives = 28/56 (50%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFR 441
           +A  +++     E+  +KGE + +L +  + W  G    T R GIFP  YV  I R
Sbjct: 895 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 950


>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
           sapiens]
          Length = 671

 Score =  111 bits (277), Expect = 3e-24
 Identities = 93/325 (28%), Positives = 152/325 (46%), Gaps = 53/325 (16%)

Query: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
           A+   +++ Q+P +L   KGDI+ + +++D+NW +GE +G  G FPA+ VEV+   ++P+
Sbjct: 385 ARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK 444

Query: 188 P--PPLCRAL--------YNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL-- 235
           P  PP  + L        Y F      K + +  L+F K + I +I +V+ENW EG++  
Sbjct: 445 PIKPPTYQVLEYGEAVAQYTF------KGDLEVELSFRKGEHICLIRKVNENWYEGRITG 498

Query: 236 GDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTS-TLRRGPGSRRK 294
             + GIFP  +V+ +   R L   + G Q   +  L+  + S+R  +S +  R P     
Sbjct: 499 TGRQGIFPASYVQVSREPR-LRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPID 557

Query: 295 VPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVGQV 354
           + GQ S      +       P  +++     P L  S  PS                   
Sbjct: 558 LGGQTSPRRTGFSFPTQEPRPQTQNL-GTPGPALSHSRGPS------------------- 597

Query: 355 STYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQ 414
              HP  +         S P + Q +    + A++ Y     DEL+L++G+ V V+ +C 
Sbjct: 598 ---HPLDLG-------TSSPNTSQ-IHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCD 646

Query: 415 DGWLRGVSLVTGRVGIFPNNYVIPI 439
           DGW  GVS  T + G FP NYV P+
Sbjct: 647 DGWFVGVSRRTQKFGTFPGNYVAPV 671



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 28/97 (28%), Positives = 42/97 (43%), Gaps = 2/97 (2%)

Query: 340 PMEKADVPSSCVGQVSTYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDEL 399
           P + AD  S  +G+    +P+      ++     P  ++            + A  P EL
Sbjct: 340 PHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKEL 399

Query: 400 DLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
            LQKG+ V +  +    WL G     GR+GIFP NYV
Sbjct: 400 TLQKGDIVYIHKEVDKNWLEGEH--HGRLGIFPANYV 434



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 41/147 (27%), Positives = 61/147 (41%), Gaps = 26/147 (17%)

Query: 374 PGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPN 433
           P + Q L     VA +++      EL  +KGE + ++ K  + W  G    TGR GIFP 
Sbjct: 448 PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPA 507

Query: 434 NYVIPIFRKTSSFPDSRSPGLYTTWTLSTSSVSSQGSISEGDPRQSRPFKSVFVPTAIVN 493
           +YV            SR P L          +   G      PR +   +S   P++  +
Sbjct: 508 SYV----------QVSREPRL---------RLCDDGPQLPTSPRLTAAARSARHPSS-PS 547

Query: 494 PVRSTAGPGTLGQGSLRKGRSSMRKNG 520
            +RS A P  LG      G++S R+ G
Sbjct: 548 ALRSPADPIDLG------GQTSPRRTG 568


>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
           sapiens]
          Length = 329

 Score =  111 bits (277), Expect = 3e-24
 Identities = 93/325 (28%), Positives = 152/325 (46%), Gaps = 53/325 (16%)

Query: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
           A+   +++ Q+P +L   KGDI+ + +++D+NW +GE +G  G FPA+ VEV+   ++P+
Sbjct: 43  ARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK 102

Query: 188 P--PPLCRAL--------YNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL-- 235
           P  PP  + L        Y F      K + +  L+F K + I +I +V+ENW EG++  
Sbjct: 103 PIKPPTYQVLEYGEAVAQYTF------KGDLEVELSFRKGEHICLIRKVNENWYEGRITG 156

Query: 236 GDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTS-TLRRGPGSRRK 294
             + GIFP  +V+ +   R L   + G Q   +  L+  + S+R  +S +  R P     
Sbjct: 157 TGRQGIFPASYVQVSREPR-LRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPID 215

Query: 295 VPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVGQV 354
           + GQ S      +       P  +++     P L  S  PS                   
Sbjct: 216 LGGQTSPRRTGFSFPTQEPRPQTQNL-GTPGPALSHSRGPS------------------- 255

Query: 355 STYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQ 414
              HP  +         S P + Q +    + A++ Y     DEL+L++G+ V V+ +C 
Sbjct: 256 ---HPLDLG-------TSSPNTSQ-IHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCD 304

Query: 415 DGWLRGVSLVTGRVGIFPNNYVIPI 439
           DGW  GVS  T + G FP NYV P+
Sbjct: 305 DGWFVGVSRRTQKFGTFPGNYVAPV 329



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 41/147 (27%), Positives = 61/147 (41%), Gaps = 26/147 (17%)

Query: 374 PGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPN 433
           P + Q L     VA +++      EL  +KGE + ++ K  + W  G    TGR GIFP 
Sbjct: 106 PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPA 165

Query: 434 NYVIPIFRKTSSFPDSRSPGLYTTWTLSTSSVSSQGSISEGDPRQSRPFKSVFVPTAIVN 493
           +YV            SR P L          +   G      PR +   +S   P++  +
Sbjct: 166 SYV----------QVSREPRL---------RLCDDGPQLPTSPRLTAAARSARHPSS-PS 205

Query: 494 PVRSTAGPGTLGQGSLRKGRSSMRKNG 520
            +RS A P  LG      G++S R+ G
Sbjct: 206 ALRSPADPIDLG------GQTSPRRTG 226


>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
           sapiens]
          Length = 905

 Score =  105 bits (262), Expect = 1e-22
 Identities = 87/323 (26%), Positives = 137/323 (42%), Gaps = 79/323 (24%)

Query: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
           A+A  +++ Q   +L   KGDI+ + +Q+D+NWY+GE +G  G FP + +E++   +  Q
Sbjct: 649 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 708

Query: 188 PPPLC--------RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GD 237
           P  L          A+  F+  G  + E    ++F K + IT++ +VDENW EG++    
Sbjct: 709 PKKLTPVQVLEYGEAIAKFNFNGDTQVE----MSFRKGERITLLRQVDENWYEGRIPGTS 764

Query: 238 KVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPG 297
           + GIFPI +V+       ++++   +      +L   SS SR  T+              
Sbjct: 765 RQGIFPITYVD-------VIKRPLVKNPVDYMDLPFSSSPSRSATA-------------- 803

Query: 298 QFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVGQVSTY 357
                           SP   H    + P L  S    V  Q  ++   P          
Sbjct: 804 ----------------SPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDR-------- 839

Query: 358 HPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGW 417
                             SQ       + AL+SY     DEL+L+ G+ V V+ KC DGW
Sbjct: 840 ------------------SQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGW 881

Query: 418 LRGVSLVTGRVGIFPNNYVIPIF 440
             G S  T + G FP NYV P++
Sbjct: 882 FVGTSRRTKQFGTFPGNYVKPLY 904



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 28/105 (26%), Positives = 45/105 (42%), Gaps = 9/105 (8%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKT-- 443
           +A  +++     E+  +KGE + +L +  + W  G    T R GIFP  YV  I R    
Sbjct: 724 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 783

Query: 444 -----SSFPDSRSPGLYTTWT--LSTSSVSSQGSISEGDPRQSRP 481
                   P S SP    T +  LS  S+ +   ++E +    +P
Sbjct: 784 NPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQP 828



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 24/87 (27%), Positives = 38/87 (43%), Gaps = 5/87 (5%)

Query: 96  LQDGRKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLR 155
           L +  KS   P   QA   R+ P+       +   +AL +Y  QN  +L    GDI+ + 
Sbjct: 818 LTESEKSYVQP---QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 874

Query: 156 RQLDENWYQGEINGIS--GNFPASSVE 180
            + D+ W+ G        G FP + V+
Sbjct: 875 EKCDDGWFVGTSRRTKQFGTFPGNYVK 901


>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
          Length = 1220

 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 87/337 (25%), Positives = 134/337 (39%), Gaps = 73/337 (21%)

Query: 129  RAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIK----- 183
            +A+AL  +R +    L FNK D+I +  Q D  W+ GE+ G  G FP S V++I      
Sbjct: 917  QAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRK 975

Query: 184  -------QLPQPPPLCR----------------ALYNFDLRGKDKSENQDCLTFLKDDII 220
                       P  L R                A+Y ++      S  Q  LTF + D+I
Sbjct: 976  STSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYE------SSEQGDLTFQQGDVI 1029

Query: 221  TVISRVDENWAEGKLGDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRG 280
             ++++ D +W  G +GDK G+FP  +V        L +      + +T +L      ++ 
Sbjct: 1030 -LVTKKDGDWWTGTVGDKAGVFPSNYVR-------LKDSEGSGTAGKTGSLGKKPEIAQV 1081

Query: 281  NTSTLRRGPGSRRKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQP 340
              S    GP      PGQ                            +LI   NP    + 
Sbjct: 1082 IASYTATGPEQLTLAPGQL---------------------------ILIRKKNPGGWWEG 1114

Query: 341  MEKADVPSSCVGQVSTYHPAPVSPGHSTAVVSLPGSQQHLSAN-MFVALHSYSAHGPDEL 399
              +A      +G     +   +SPG S    + P     L+A    + ++ Y+A   DEL
Sbjct: 1115 ELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDEL 1174

Query: 400  DLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
               KG+ + VL K    W +G   V G+VG+FP+NYV
Sbjct: 1175 AFNKGQIINVLNKEDPDWWKGE--VNGQVGLFPSNYV 1209



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 38/136 (27%), Positives = 69/136 (50%), Gaps = 21/136 (15%)

Query: 130  AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS-----GNFPASSVEVI-- 182
            A+ + +Y    P  L    G +IL+R++    W++GE+         G FPA+ V+++  
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138

Query: 183  ---KQLPQPPP-------LCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAE 232
               K  P  PP       +C+ +  +D      ++N D L F K  II V+++ D +W +
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYT----AQNDDELAFNKGQIINVLNKEDPDWWK 1194

Query: 233  GKLGDKVGIFPILFVE 248
            G++  +VG+FP  +V+
Sbjct: 1195 GEVNGQVGLFPSNYVK 1210



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 20/47 (42%), Positives = 32/47 (68%)

Query: 135  NYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEV 181
            +Y  QN  +L FNKG II +  + D +W++GE+NG  G FP++ V++
Sbjct: 1165 DYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKL 1211



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 19/68 (27%), Positives = 37/68 (54%), Gaps = 7/68 (10%)

Query: 131 KALCNYRGQNPGDLRFNKGDIILLRRQ-LDEN------WYQGEINGISGNFPASSVEVIK 183
           +AL  +  ++  ++    GDI++++ + +DE+      W  GE+ G +G FPA+  E I 
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805

Query: 184 QLPQPPPL 191
           +   P P+
Sbjct: 806 ENEVPAPV 813


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 87/337 (25%), Positives = 134/337 (39%), Gaps = 73/337 (21%)

Query: 129  RAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIK----- 183
            +A+AL  +R +    L FNK D+I +  Q D  W+ GE+ G  G FP S V++I      
Sbjct: 917  QAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRK 975

Query: 184  -------QLPQPPPLCR----------------ALYNFDLRGKDKSENQDCLTFLKDDII 220
                       P  L R                A+Y ++      S  Q  LTF + D+I
Sbjct: 976  STSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYE------SSEQGDLTFQQGDVI 1029

Query: 221  TVISRVDENWAEGKLGDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRG 280
             ++++ D +W  G +GDK G+FP  +V        L +      + +T +L      ++ 
Sbjct: 1030 -LVTKKDGDWWTGTVGDKAGVFPSNYVR-------LKDSEGSGTAGKTGSLGKKPEIAQV 1081

Query: 281  NTSTLRRGPGSRRKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQP 340
              S    GP      PGQ                            +LI   NP    + 
Sbjct: 1082 IASYTATGPEQLTLAPGQL---------------------------ILIRKKNPGGWWEG 1114

Query: 341  MEKADVPSSCVGQVSTYHPAPVSPGHSTAVVSLPGSQQHLSAN-MFVALHSYSAHGPDEL 399
              +A      +G     +   +SPG S    + P     L+A    + ++ Y+A   DEL
Sbjct: 1115 ELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDEL 1174

Query: 400  DLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
               KG+ + VL K    W +G   V G+VG+FP+NYV
Sbjct: 1175 AFNKGQIINVLNKEDPDWWKGE--VNGQVGLFPSNYV 1209



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 33/125 (26%), Positives = 63/125 (50%), Gaps = 13/125 (10%)

Query: 135  NYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQLPQPPPLCRA 194
            +Y  QN  +L FNKG II +  + D +W++GE+NG  G FP++ V++   +      C  
Sbjct: 1165 DYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWCSD 1224

Query: 195  LYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVGIFPILFVEPNLTAR 254
            L+  D+    + + Q    ++ + I+T     +EN+      + + +   +F +P + + 
Sbjct: 1225 LHLLDMLTPTERKRQG---YIHELIVT-----EENYV-----NDLQLVTEIFQKPLMESE 1271

Query: 255  HLLEK 259
             L EK
Sbjct: 1272 LLTEK 1276



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 19/68 (27%), Positives = 37/68 (54%), Gaps = 7/68 (10%)

Query: 131 KALCNYRGQNPGDLRFNKGDIILLRRQ-LDEN------WYQGEINGISGNFPASSVEVIK 183
           +AL  +  ++  ++    GDI++++ + +DE+      W  GE+ G +G FPA+  E I 
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805

Query: 184 QLPQPPPL 191
           +   P P+
Sbjct: 806 ENEVPAPV 813


>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
           sapiens]
          Length = 492

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 54/168 (32%), Positives = 87/168 (51%), Gaps = 26/168 (15%)

Query: 101 KSRTNPRRLQASPFRLVPNVRIHMDGVPR-----AKALCNYRGQNPGDLRFNKGDIILLR 155
           K R +PR   ++   +  +      G P      AKA+ +++ Q   +L F KGD + + 
Sbjct: 226 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 285

Query: 156 RQLDENWYQGEINGISGNFPASSVEVI-----KQLPQPPPLCR--------ALYNFDLRG 202
           R++D+NWY+GE +G  G FP S VE +      Q  +PPP  +        A YNF+   
Sbjct: 286 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFN--- 342

Query: 203 KDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GDKVGIFPILFVE 248
              ++    L+  K D + ++ RVD+NW EGK+   ++ GIFP+ +VE
Sbjct: 343 ---ADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 387



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 47/148 (31%)

Query: 127 VPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVEVIKQ 184
           +  A A  N+      +L   KGD ++L +++D+NWY+G+I G +  G FP S VEV+K+
Sbjct: 332 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 391

Query: 185 -------LPQPP--------------------PLC------------RALYNFDLRGKDK 205
                   P PP                    P+             +ALYN+  R    
Sbjct: 392 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPR---- 447

Query: 206 SENQDCLTFLKDDIITVISRVDENWAEG 233
             N+D L   + D+I V+ + D+ W  G
Sbjct: 448 --NEDELELRESDVIDVMEKCDDGWFVG 473



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 23/52 (44%), Positives = 32/52 (61%)

Query: 385 FVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           F AL++Y+    DEL+L++ + + V+ KC DGW  G S  T   G FP NYV
Sbjct: 438 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 489



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 3/75 (4%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKT-- 443
           +A ++++A    EL L+KG+ V +L +    W  G    T R GIFP +YV  + + T  
Sbjct: 336 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 395

Query: 444 -SSFPDSRSPGLYTT 457
              +PD   P  Y++
Sbjct: 396 AEDYPDPPIPHSYSS 410



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 2/50 (4%)

Query: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           A++ + A    EL  +KG+ V +L K    W  G     GRVGIFP +YV
Sbjct: 262 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH--HGRVGIFPISYV 309



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 15/52 (28%), Positives = 26/52 (50%), Gaps = 2/52 (3%)

Query: 131 KALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVE 180
           +AL NY  +N  +L   + D+I +  + D+ W+ G        G FP + V+
Sbjct: 439 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490


>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
           sapiens]
          Length = 1004

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 60/185 (32%), Positives = 97/185 (52%), Gaps = 38/185 (20%)

Query: 84  RGGSFR-----RPGTMTLQDGRKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRG 138
           RGG+ +     R  + TL D    R+ PR  + +P +         + +P AKA+ +++ 
Sbjct: 733 RGGALQDRESPRSYSSTLTD--MGRSAPRERRGTPEK---------EKLP-AKAVYDFKA 780

Query: 139 QNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI-----KQLPQPPPLCR 193
           Q   +L F KGD + + R++D+NWY+GE +G  G FP S VE +      Q  +PPP  +
Sbjct: 781 QTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQ 840

Query: 194 --------ALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GDKVGIFP 243
                   A YNF+      ++    L+  K D + ++ RVD+NW EGK+   ++ GIFP
Sbjct: 841 PGEIGEAIAKYNFN------ADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFP 894

Query: 244 ILFVE 248
           + +VE
Sbjct: 895 VSYVE 899



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 47/148 (31%)

Query: 127 VPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVEVIKQ 184
           +  A A  N+      +L   KGD ++L +++D+NWY+G+I G +  G FP S VEV+K+
Sbjct: 844 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 903

Query: 185 -------LPQPP--------------------PLC------------RALYNFDLRGKDK 205
                   P PP                    P+             +ALYN+  R    
Sbjct: 904 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPR---- 959

Query: 206 SENQDCLTFLKDDIITVISRVDENWAEG 233
             N+D L   + D+I V+ + D+ W  G
Sbjct: 960 --NEDELELRESDVIDVMEKCDDGWFVG 985



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 23/52 (44%), Positives = 32/52 (61%)

Query: 385  FVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
            F AL++Y+    DEL+L++ + + V+ KC DGW  G S  T   G FP NYV
Sbjct: 950  FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1001



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 3/75 (4%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKT-- 443
           +A ++++A    EL L+KG+ V +L +    W  G    T R GIFP +YV  + + T  
Sbjct: 848 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 907

Query: 444 -SSFPDSRSPGLYTT 457
              +PD   P  Y++
Sbjct: 908 AEDYPDPPIPHSYSS 922



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 2/50 (4%)

Query: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           A++ + A    EL  +KG+ V +L K    W  G     GRVGIFP +YV
Sbjct: 774 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH--HGRVGIFPISYV 821



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 15/52 (28%), Positives = 26/52 (50%), Gaps = 2/52 (3%)

Query: 131  KALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVE 180
            +AL NY  +N  +L   + D+I +  + D+ W+ G        G FP + V+
Sbjct: 951  QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002


>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
           sapiens]
          Length = 824

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 54/168 (32%), Positives = 87/168 (51%), Gaps = 26/168 (15%)

Query: 101 KSRTNPRRLQASPFRLVPNVRIHMDGVPR-----AKALCNYRGQNPGDLRFNKGDIILLR 155
           K R +PR   ++   +  +      G P      AKA+ +++ Q   +L F KGD + + 
Sbjct: 558 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 617

Query: 156 RQLDENWYQGEINGISGNFPASSVEVI-----KQLPQPPPLCR--------ALYNFDLRG 202
           R++D+NWY+GE +G  G FP S VE +      Q  +PPP  +        A YNF+   
Sbjct: 618 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFN--- 674

Query: 203 KDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GDKVGIFPILFVE 248
              ++    L+  K D + ++ RVD+NW EGK+   ++ GIFP+ +VE
Sbjct: 675 ---ADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 719



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 47/148 (31%)

Query: 127 VPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVEVIKQ 184
           +  A A  N+      +L   KGD ++L +++D+NWY+G+I G +  G FP S VEV+K+
Sbjct: 664 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 723

Query: 185 -------LPQPP--------------------PLC------------RALYNFDLRGKDK 205
                   P PP                    P+             +ALYN+  R    
Sbjct: 724 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPR---- 779

Query: 206 SENQDCLTFLKDDIITVISRVDENWAEG 233
             N+D L   + D+I V+ + D+ W  G
Sbjct: 780 --NEDELELRESDVIDVMEKCDDGWFVG 805



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 23/52 (44%), Positives = 32/52 (61%)

Query: 385 FVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           F AL++Y+    DEL+L++ + + V+ KC DGW  G S  T   G FP NYV
Sbjct: 770 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 821



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 3/75 (4%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKT-- 443
           +A ++++A    EL L+KG+ V +L +    W  G    T R GIFP +YV  + + T  
Sbjct: 668 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 727

Query: 444 -SSFPDSRSPGLYTT 457
              +PD   P  Y++
Sbjct: 728 AEDYPDPPIPHSYSS 742



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 2/50 (4%)

Query: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           A++ + A    EL  +KG+ V +L K    W  G     GRVGIFP +YV
Sbjct: 594 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH--HGRVGIFPISYV 641



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 15/52 (28%), Positives = 26/52 (50%), Gaps = 2/52 (3%)

Query: 131 KALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVE 180
           +AL NY  +N  +L   + D+I +  + D+ W+ G        G FP + V+
Sbjct: 771 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822


>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
           sapiens]
          Length = 661

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 54/168 (32%), Positives = 87/168 (51%), Gaps = 26/168 (15%)

Query: 101 KSRTNPRRLQASPFRLVPNVRIHMDGVPR-----AKALCNYRGQNPGDLRFNKGDIILLR 155
           K R +PR   ++   +  +      G P      AKA+ +++ Q   +L F KGD + + 
Sbjct: 395 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 454

Query: 156 RQLDENWYQGEINGISGNFPASSVEVI-----KQLPQPPPLCR--------ALYNFDLRG 202
           R++D+NWY+GE +G  G FP S VE +      Q  +PPP  +        A YNF+   
Sbjct: 455 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFN--- 511

Query: 203 KDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GDKVGIFPILFVE 248
              ++    L+  K D + ++ RVD+NW EGK+   ++ GIFP+ +VE
Sbjct: 512 ---ADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 556



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 47/148 (31%)

Query: 127 VPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVEVIKQ 184
           +  A A  N+      +L   KGD ++L +++D+NWY+G+I G +  G FP S VEV+K+
Sbjct: 501 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 560

Query: 185 -------LPQPP--------------------PLC------------RALYNFDLRGKDK 205
                   P PP                    P+             +ALYN+  R    
Sbjct: 561 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPR---- 616

Query: 206 SENQDCLTFLKDDIITVISRVDENWAEG 233
             N+D L   + D+I V+ + D+ W  G
Sbjct: 617 --NEDELELRESDVIDVMEKCDDGWFVG 642



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 23/52 (44%), Positives = 32/52 (61%)

Query: 385 FVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           F AL++Y+    DEL+L++ + + V+ KC DGW  G S  T   G FP NYV
Sbjct: 607 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 658



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 3/75 (4%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKT-- 443
           +A ++++A    EL L+KG+ V +L +    W  G    T R GIFP +YV  + + T  
Sbjct: 505 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 564

Query: 444 -SSFPDSRSPGLYTT 457
              +PD   P  Y++
Sbjct: 565 AEDYPDPPIPHSYSS 579



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 2/50 (4%)

Query: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           A++ + A    EL  +KG+ V +L K    W  G     GRVGIFP +YV
Sbjct: 431 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH--HGRVGIFPISYV 478



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 15/52 (28%), Positives = 26/52 (50%), Gaps = 2/52 (3%)

Query: 131 KALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVE 180
           +AL NY  +N  +L   + D+I +  + D+ W+ G        G FP + V+
Sbjct: 608 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 659


>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
           sapiens]
          Length = 731

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 54/168 (32%), Positives = 87/168 (51%), Gaps = 26/168 (15%)

Query: 101 KSRTNPRRLQASPFRLVPNVRIHMDGVPR-----AKALCNYRGQNPGDLRFNKGDIILLR 155
           K R +PR   ++   +  +      G P      AKA+ +++ Q   +L F KGD + + 
Sbjct: 465 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 524

Query: 156 RQLDENWYQGEINGISGNFPASSVEVI-----KQLPQPPPLCR--------ALYNFDLRG 202
           R++D+NWY+GE +G  G FP S VE +      Q  +PPP  +        A YNF+   
Sbjct: 525 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFN--- 581

Query: 203 KDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GDKVGIFPILFVE 248
              ++    L+  K D + ++ RVD+NW EGK+   ++ GIFP+ +VE
Sbjct: 582 ---ADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 626



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 47/148 (31%)

Query: 127 VPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVEVIKQ 184
           +  A A  N+      +L   KGD ++L +++D+NWY+G+I G +  G FP S VEV+K+
Sbjct: 571 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 630

Query: 185 -------LPQPP--------------------PLC------------RALYNFDLRGKDK 205
                   P PP                    P+             +ALYN+  R    
Sbjct: 631 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPR---- 686

Query: 206 SENQDCLTFLKDDIITVISRVDENWAEG 233
             N+D L   + D+I V+ + D+ W  G
Sbjct: 687 --NEDELELRESDVIDVMEKCDDGWFVG 712



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 23/52 (44%), Positives = 32/52 (61%)

Query: 385 FVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           F AL++Y+    DEL+L++ + + V+ KC DGW  G S  T   G FP NYV
Sbjct: 677 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 728



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 3/75 (4%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKT-- 443
           +A ++++A    EL L+KG+ V +L +    W  G    T R GIFP +YV  + + T  
Sbjct: 575 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 634

Query: 444 -SSFPDSRSPGLYTT 457
              +PD   P  Y++
Sbjct: 635 AEDYPDPPIPHSYSS 649



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 2/50 (4%)

Query: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           A++ + A    EL  +KG+ V +L K    W  G     GRVGIFP +YV
Sbjct: 501 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH--HGRVGIFPISYV 548



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 15/52 (28%), Positives = 26/52 (50%), Gaps = 2/52 (3%)

Query: 131 KALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVE 180
           +AL NY  +N  +L   + D+I +  + D+ W+ G        G FP + V+
Sbjct: 678 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729


>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
           sapiens]
          Length = 644

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 54/168 (32%), Positives = 87/168 (51%), Gaps = 26/168 (15%)

Query: 101 KSRTNPRRLQASPFRLVPNVRIHMDGVPR-----AKALCNYRGQNPGDLRFNKGDIILLR 155
           K R +PR   ++   +  +      G P      AKA+ +++ Q   +L F KGD + + 
Sbjct: 378 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 437

Query: 156 RQLDENWYQGEINGISGNFPASSVEVI-----KQLPQPPPLCR--------ALYNFDLRG 202
           R++D+NWY+GE +G  G FP S VE +      Q  +PPP  +        A YNF+   
Sbjct: 438 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFN--- 494

Query: 203 KDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GDKVGIFPILFVE 248
              ++    L+  K D + ++ RVD+NW EGK+   ++ GIFP+ +VE
Sbjct: 495 ---ADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 539



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 47/148 (31%)

Query: 127 VPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVEVIKQ 184
           +  A A  N+      +L   KGD ++L +++D+NWY+G+I G +  G FP S VEV+K+
Sbjct: 484 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 543

Query: 185 -------LPQPP--------------------PLC------------RALYNFDLRGKDK 205
                   P PP                    P+             +ALYN+  R    
Sbjct: 544 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPR---- 599

Query: 206 SENQDCLTFLKDDIITVISRVDENWAEG 233
             N+D L   + D+I V+ + D+ W  G
Sbjct: 600 --NEDELELRESDVIDVMEKCDDGWFVG 625



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 23/52 (44%), Positives = 32/52 (61%)

Query: 385 FVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           F AL++Y+    DEL+L++ + + V+ KC DGW  G S  T   G FP NYV
Sbjct: 590 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 641



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 3/75 (4%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKT-- 443
           +A ++++A    EL L+KG+ V +L +    W  G    T R GIFP +YV  + + T  
Sbjct: 488 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 547

Query: 444 -SSFPDSRSPGLYTT 457
              +PD   P  Y++
Sbjct: 548 AEDYPDPPIPHSYSS 562



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 2/50 (4%)

Query: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           A++ + A    EL  +KG+ V +L K    W  G     GRVGIFP +YV
Sbjct: 414 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH--HGRVGIFPISYV 461



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 15/52 (28%), Positives = 26/52 (50%), Gaps = 2/52 (3%)

Query: 131 KALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVE 180
           +AL NY  +N  +L   + D+I +  + D+ W+ G        G FP + V+
Sbjct: 591 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642


>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
           sapiens]
          Length = 1100

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 60/185 (32%), Positives = 97/185 (52%), Gaps = 38/185 (20%)

Query: 84  RGGSFR-----RPGTMTLQDGRKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRG 138
           RGG+ +     R  + TL D    R+ PR  + +P +         + +P AKA+ +++ 
Sbjct: 829 RGGALQDRESPRSYSSTLTD--MGRSAPRERRGTPEK---------EKLP-AKAVYDFKA 876

Query: 139 QNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI-----KQLPQPPPLCR 193
           Q   +L F KGD + + R++D+NWY+GE +G  G FP S VE +      Q  +PPP  +
Sbjct: 877 QTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQ 936

Query: 194 --------ALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GDKVGIFP 243
                   A YNF+      ++    L+  K D + ++ RVD+NW EGK+   ++ GIFP
Sbjct: 937 PGEIGEAIAKYNFN------ADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFP 990

Query: 244 ILFVE 248
           + +VE
Sbjct: 991 VSYVE 995



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 47/148 (31%)

Query: 127  VPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVEVIKQ 184
            +  A A  N+      +L   KGD ++L +++D+NWY+G+I G +  G FP S VEV+K+
Sbjct: 940  IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 999

Query: 185  -------LPQPP--------------------PLC------------RALYNFDLRGKDK 205
                    P PP                    P+             +ALYN+  R    
Sbjct: 1000 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPR---- 1055

Query: 206  SENQDCLTFLKDDIITVISRVDENWAEG 233
              N+D L   + D+I V+ + D+ W  G
Sbjct: 1056 --NEDELELRESDVIDVMEKCDDGWFVG 1081



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 23/52 (44%), Positives = 32/52 (61%)

Query: 385  FVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
            F AL++Y+    DEL+L++ + + V+ KC DGW  G S  T   G FP NYV
Sbjct: 1046 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1097



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 3/75 (4%)

Query: 386  VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKT-- 443
            +A ++++A    EL L+KG+ V +L +    W  G    T R GIFP +YV  + + T  
Sbjct: 944  IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 1003

Query: 444  -SSFPDSRSPGLYTT 457
               +PD   P  Y++
Sbjct: 1004 AEDYPDPPIPHSYSS 1018



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 2/50 (4%)

Query: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           A++ + A    EL  +KG+ V +L K    W  G     GRVGIFP +YV
Sbjct: 870 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH--HGRVGIFPISYV 917



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 15/52 (28%), Positives = 26/52 (50%), Gaps = 2/52 (3%)

Query: 131  KALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVE 180
            +AL NY  +N  +L   + D+I +  + D+ W+ G        G FP + V+
Sbjct: 1047 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098


>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
           sapiens]
          Length = 666

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 54/168 (32%), Positives = 87/168 (51%), Gaps = 26/168 (15%)

Query: 101 KSRTNPRRLQASPFRLVPNVRIHMDGVPR-----AKALCNYRGQNPGDLRFNKGDIILLR 155
           K R +PR   ++   +  +      G P      AKA+ +++ Q   +L F KGD + + 
Sbjct: 400 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 459

Query: 156 RQLDENWYQGEINGISGNFPASSVEVI-----KQLPQPPPLCR--------ALYNFDLRG 202
           R++D+NWY+GE +G  G FP S VE +      Q  +PPP  +        A YNF+   
Sbjct: 460 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFN--- 516

Query: 203 KDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GDKVGIFPILFVE 248
              ++    L+  K D + ++ RVD+NW EGK+   ++ GIFP+ +VE
Sbjct: 517 ---ADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 561



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 47/148 (31%)

Query: 127 VPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVEVIKQ 184
           +  A A  N+      +L   KGD ++L +++D+NWY+G+I G +  G FP S VEV+K+
Sbjct: 506 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 565

Query: 185 -------LPQPP--------------------PLC------------RALYNFDLRGKDK 205
                   P PP                    P+             +ALYN+  R    
Sbjct: 566 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPR---- 621

Query: 206 SENQDCLTFLKDDIITVISRVDENWAEG 233
             N+D L   + D+I V+ + D+ W  G
Sbjct: 622 --NEDELELRESDVIDVMEKCDDGWFVG 647



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 23/52 (44%), Positives = 32/52 (61%)

Query: 385 FVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           F AL++Y+    DEL+L++ + + V+ KC DGW  G S  T   G FP NYV
Sbjct: 612 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 663



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 3/75 (4%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKT-- 443
           +A ++++A    EL L+KG+ V +L +    W  G    T R GIFP +YV  + + T  
Sbjct: 510 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 569

Query: 444 -SSFPDSRSPGLYTT 457
              +PD   P  Y++
Sbjct: 570 AEDYPDPPIPHSYSS 584



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 2/50 (4%)

Query: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           A++ + A    EL  +KG+ V +L K    W  G     GRVGIFP +YV
Sbjct: 436 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH--HGRVGIFPISYV 483



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 15/52 (28%), Positives = 26/52 (50%), Gaps = 2/52 (3%)

Query: 131 KALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS--GNFPASSVE 180
           +AL NY  +N  +L   + D+I +  + D+ W+ G        G FP + V+
Sbjct: 613 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 664


>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
            sapiens]
          Length = 1292

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 60/224 (26%), Positives = 110/224 (49%), Gaps = 26/224 (11%)

Query: 130  AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
            A+A  +++ Q   +L   KGDI+ + +Q+D+NWY+GE +G  G FP + +E++   +  Q
Sbjct: 798  ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 857

Query: 188  PPPLC--------RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GD 237
            P  L          A+  F+  G  + E    ++F K + IT++ +VDENW EG++    
Sbjct: 858  PKKLTPVQVLEYGEAIAKFNFNGDTQVE----MSFRKGERITLLRQVDENWYEGRIPGTS 913

Query: 238  KVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPG 297
            + GIFPI +V+       ++++   +      +L   SS SR  T++ +    S+   P 
Sbjct: 914  RQGIFPITYVD-------VIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLITPA 966

Query: 298  QFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPM 341
              S+  +   L+  +H+ +      IS  V +       +T P+
Sbjct: 967  PSSLPHSRRALSPEMHAVTSEW---ISLTVGVPGRRSLALTPPL 1007



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 26/56 (46%), Positives = 35/56 (62%)

Query: 385  FVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIF 440
            + AL+SY     DEL+L+ G+ V V+ KC DGW  G S  T + G FP NYV P++
Sbjct: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 1291



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 25/88 (28%), Positives = 41/88 (46%), Gaps = 4/88 (4%)

Query: 97   QDGRKS--RTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILL 154
            Q GRK+  R   ++ QA   R+ P+       +   +AL +Y  QN  +L    GDI+ +
Sbjct: 1201 QAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 1260

Query: 155  RRQLDENWYQGEINGIS--GNFPASSVE 180
              + D+ W+ G        G FP + V+
Sbjct: 1261 MEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 2/50 (4%)

Query: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           A   + A    EL LQKG+ V +  +    W  G     GRVGIFP  Y+
Sbjct: 800 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH--HGRVGIFPRTYI 847



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 18/56 (32%), Positives = 28/56 (50%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFR 441
           +A  +++     E+  +KGE + +L +  + W  G    T R GIFP  YV  I R
Sbjct: 873 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 928


>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
          Length = 731

 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 45/149 (30%), Positives = 72/149 (48%), Gaps = 34/149 (22%)

Query: 129 RAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQLPQ- 187
           R  A   Y G+   +L F++G+II+L+  ++E W +GE+ G +G FP + VE ++  P  
Sbjct: 516 RCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS 575

Query: 188 ---------------------------PPPLCRALYNFDLRGKDKSENQDCLTFLKDDII 220
                                      P   C AL++F       +E  D L+F + D I
Sbjct: 576 GANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFT------AETSDDLSFKRGDRI 629

Query: 221 TVISRVDENWAEGKLGDKVGIFPILFVEP 249
            ++ R+D +W  G+L D+ GIFP +FV P
Sbjct: 630 QILERLDSDWCRGRLQDREGIFPAVFVRP 658



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 44/136 (32%), Positives = 69/136 (50%), Gaps = 16/136 (11%)

Query: 126 GVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQL 185
           G P A  L ++  +   DL    G+I+ L  ++D +WY+G      G FPA+ V+VI  +
Sbjct: 437 GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDI 496

Query: 186 PQ--------PPPLC----RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEG 233
           P+            C    R +  F+  G+ K E    L+F + +II +   V+E WA G
Sbjct: 497 PEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDE----LSFSEGEIIILKEYVNEEWARG 552

Query: 234 KLGDKVGIFPILFVEP 249
           ++  + GIFP+ FVEP
Sbjct: 553 EVRGRTGIFPLNFVEP 568



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 43/123 (34%), Positives = 64/123 (52%), Gaps = 9/123 (7%)

Query: 131 KALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSV-----EVIKQL 185
           +AL ++  +   DL F +GD I +  +LD +W +G +    G FPA  V     E    L
Sbjct: 608 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSML 667

Query: 186 PQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVGIFPIL 245
              P   +A   +D RG    EN+D L+F   DIIT +  VD++W  G+L  K GIFP  
Sbjct: 668 AIVPKGRKAKALYDFRG----ENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKN 723

Query: 246 FVE 248
           +++
Sbjct: 724 YIQ 726



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 72/315 (22%), Positives = 132/315 (41%), Gaps = 53/315 (16%)

Query: 145 RFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQL-------PQPP-------- 189
           ++ +GD++++ +Q + N+ + +    +G    S +++I  L       P  P        
Sbjct: 376 KYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVD 435

Query: 190 ---PLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVGIFPILF 246
              P    L++F       +E  D L     +I+ ++ ++D +W  G   +++GIFP  +
Sbjct: 436 SGAPHAVVLHDFP------AEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANY 489

Query: 247 VEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPGQFSITTALN 306
           V+       +++  +G    R     + S   +G+    R      +K    FS    + 
Sbjct: 490 VKV------IIDIPEGGNGKRE---CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEII- 539

Query: 307 TLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVGQVSTYHPAPVSP-- 364
            L   V+    R  V   T +      P    +P+E  D P+S    +ST  P       
Sbjct: 540 ILKEYVNEEWARGEVRGRTGIF-----PLNFVEPVE--DYPTSGANVLSTKVPLKTKKED 592

Query: 365 -GHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSL 423
            G ++ V SLP       A    ALHS++A   D+L  ++G+ +++L +    W RG   
Sbjct: 593 SGSNSQVNSLP-------AEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--R 643

Query: 424 VTGRVGIFPNNYVIP 438
           +  R GIFP  +V P
Sbjct: 644 LQDREGIFPAVFVRP 658



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 22/55 (40%), Positives = 36/55 (65%)

Query: 129 RAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIK 183
           +AKAL ++RG+N  +L F  GDII     +D++W  GE+ G SG FP + ++ ++
Sbjct: 675 KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQ 729



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 31/88 (35%), Positives = 40/88 (45%), Gaps = 7/88 (7%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSS 445
           VA   Y     DEL   +GE + +     + W RG   V GR GIFP N+V P+      
Sbjct: 518 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGE--VRGRTGIFPLNFVEPV----ED 571

Query: 446 FPDSRSPGLYTTWTLSTSSVSSQGSISE 473
           +P S +  L T   L T    S GS S+
Sbjct: 572 YPTSGANVLSTKVPLKTKKEDS-GSNSQ 598



 Score = 37.0 bits (84), Expect = 0.065
 Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 2/50 (4%)

Query: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           AL+ +     DEL  + G+ +  L    D W+ G   + G+ GIFP NY+
Sbjct: 678 ALYDFRGENEDELSFKAGDIITELESVDDDWMSGE--LMGKSGIFPKNYI 725



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 30/120 (25%), Positives = 50/120 (41%), Gaps = 26/120 (21%)

Query: 589 SEARIHSAASSLIMEDKEIPIKSEPLPKPPASAP-------------PSILVKPENSR-- 633
           +E   +S  S + + + +  I++  LPK P   P             PS+  KP  +R  
Sbjct: 6   TEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPAANRAS 65

Query: 634 ----NGIEKQVKTVRFQNYSP-PPTKHYTSHPTSGKPE-----QPATLKASQPEAASLGP 683
               +G E ++K    +  +P PP +   S P + KPE      P  +++  PE    GP
Sbjct: 66  GEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVT-KPELPKKPNPGLIRSVNPEIPGRGP 124


>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
          Length = 767

 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 45/149 (30%), Positives = 72/149 (48%), Gaps = 34/149 (22%)

Query: 129 RAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQLPQ- 187
           R  A   Y G+   +L F++G+II+L+  ++E W +GE+ G +G FP + VE ++  P  
Sbjct: 552 RCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS 611

Query: 188 ---------------------------PPPLCRALYNFDLRGKDKSENQDCLTFLKDDII 220
                                      P   C AL++F       +E  D L+F + D I
Sbjct: 612 GANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFT------AETSDDLSFKRGDRI 665

Query: 221 TVISRVDENWAEGKLGDKVGIFPILFVEP 249
            ++ R+D +W  G+L D+ GIFP +FV P
Sbjct: 666 QILERLDSDWCRGRLQDREGIFPAVFVRP 694



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 44/136 (32%), Positives = 69/136 (50%), Gaps = 16/136 (11%)

Query: 126 GVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQL 185
           G P A  L ++  +   DL    G+I+ L  ++D +WY+G      G FPA+ V+VI  +
Sbjct: 473 GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDI 532

Query: 186 PQ--------PPPLC----RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEG 233
           P+            C    R +  F+  G+ K E    L+F + +II +   V+E WA G
Sbjct: 533 PEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDE----LSFSEGEIIILKEYVNEEWARG 588

Query: 234 KLGDKVGIFPILFVEP 249
           ++  + GIFP+ FVEP
Sbjct: 589 EVRGRTGIFPLNFVEP 604



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 43/123 (34%), Positives = 64/123 (52%), Gaps = 9/123 (7%)

Query: 131 KALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSV-----EVIKQL 185
           +AL ++  +   DL F +GD I +  +LD +W +G +    G FPA  V     E    L
Sbjct: 644 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSML 703

Query: 186 PQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVGIFPIL 245
              P   +A   +D RG    EN+D L+F   DIIT +  VD++W  G+L  K GIFP  
Sbjct: 704 AIVPKGRKAKALYDFRG----ENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKN 759

Query: 246 FVE 248
           +++
Sbjct: 760 YIQ 762



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 72/315 (22%), Positives = 132/315 (41%), Gaps = 53/315 (16%)

Query: 145 RFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQL-------PQPP-------- 189
           ++ +GD++++ +Q + N+ + +    +G    S +++I  L       P  P        
Sbjct: 412 KYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVD 471

Query: 190 ---PLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVGIFPILF 246
              P    L++F       +E  D L     +I+ ++ ++D +W  G   +++GIFP  +
Sbjct: 472 SGAPHAVVLHDFP------AEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANY 525

Query: 247 VEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPGQFSITTALN 306
           V+       +++  +G    R     + S   +G+    R      +K    FS    + 
Sbjct: 526 VKV------IIDIPEGGNGKRE---CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEII- 575

Query: 307 TLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVGQVSTYHPAPVSP-- 364
            L   V+    R  V   T +      P    +P+E  D P+S    +ST  P       
Sbjct: 576 ILKEYVNEEWARGEVRGRTGIF-----PLNFVEPVE--DYPTSGANVLSTKVPLKTKKED 628

Query: 365 -GHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSL 423
            G ++ V SLP       A    ALHS++A   D+L  ++G+ +++L +    W RG   
Sbjct: 629 SGSNSQVNSLP-------AEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--R 679

Query: 424 VTGRVGIFPNNYVIP 438
           +  R GIFP  +V P
Sbjct: 680 LQDREGIFPAVFVRP 694



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 22/55 (40%), Positives = 36/55 (65%)

Query: 129 RAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIK 183
           +AKAL ++RG+N  +L F  GDII     +D++W  GE+ G SG FP + ++ ++
Sbjct: 711 KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQ 765



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 31/88 (35%), Positives = 40/88 (45%), Gaps = 7/88 (7%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSS 445
           VA   Y     DEL   +GE + +     + W RG   V GR GIFP N+V P+      
Sbjct: 554 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGE--VRGRTGIFPLNFVEPV----ED 607

Query: 446 FPDSRSPGLYTTWTLSTSSVSSQGSISE 473
           +P S +  L T   L T    S GS S+
Sbjct: 608 YPTSGANVLSTKVPLKTKKEDS-GSNSQ 634



 Score = 37.0 bits (84), Expect = 0.065
 Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 2/50 (4%)

Query: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           AL+ +     DEL  + G+ +  L    D W+ G   + G+ GIFP NY+
Sbjct: 714 ALYDFRGENEDELSFKAGDIITELESVDDDWMSGE--LMGKSGIFPKNYI 761



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 30/120 (25%), Positives = 50/120 (41%), Gaps = 26/120 (21%)

Query: 589 SEARIHSAASSLIMEDKEIPIKSEPLPKPPASAP-------------PSILVKPENSR-- 633
           +E   +S  S + + + +  I++  LPK P   P             PS+  KP  +R  
Sbjct: 6   TEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPAANRAS 65

Query: 634 ----NGIEKQVKTVRFQNYSP-PPTKHYTSHPTSGKPE-----QPATLKASQPEAASLGP 683
               +G E ++K    +  +P PP +   S P + KPE      P  +++  PE    GP
Sbjct: 66  GEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVT-KPELPKKPNPGLIRSVNPEIPGRGP 124


>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
          Length = 790

 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 45/149 (30%), Positives = 72/149 (48%), Gaps = 34/149 (22%)

Query: 129 RAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQLPQ- 187
           R  A   Y G+   +L F++G+II+L+  ++E W +GE+ G +G FP + VE ++  P  
Sbjct: 575 RCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS 634

Query: 188 ---------------------------PPPLCRALYNFDLRGKDKSENQDCLTFLKDDII 220
                                      P   C AL++F       +E  D L+F + D I
Sbjct: 635 GANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFT------AETSDDLSFKRGDRI 688

Query: 221 TVISRVDENWAEGKLGDKVGIFPILFVEP 249
            ++ R+D +W  G+L D+ GIFP +FV P
Sbjct: 689 QILERLDSDWCRGRLQDREGIFPAVFVRP 717



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 81/337 (24%), Positives = 142/337 (42%), Gaps = 53/337 (15%)

Query: 123 HMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI 182
           +M  VP   A  +   QNPG+L   +GD++++ +Q + N+ + +    +G    S +++I
Sbjct: 413 YMLSVPHGIANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKII 472

Query: 183 KQL-------PQPP-----------PLCRALYNFDLRGKDKSENQDCLTFLKDDIITVIS 224
             L       P  P           P    L++F       +E  D L     +I+ ++ 
Sbjct: 473 TPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDF------PAEQVDDLNLTSGEIVYLLE 526

Query: 225 RVDENWAEGKLGDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTST 284
           ++D +W  G   +++GIFP  +V      + +++  +G    R     + S   +G+   
Sbjct: 527 KIDTDWYRGNCRNQIGIFPANYV------KVIIDIPEGGNGKRE---CVSSHCVKGSRCV 577

Query: 285 LRRGPGSRRKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKA 344
            R      +K    FS    +  L   V+    R  V   T +      P    +P+E  
Sbjct: 578 ARFEYIGEQKDELSFS-EGEIIILKEYVNEEWARGEVRGRTGIF-----PLNFVEPVE-- 629

Query: 345 DVPSSCVGQVSTYHPAPV---SPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDL 401
           D P+S    +ST  P        G ++ V SLP       A    ALHS++A   D+L  
Sbjct: 630 DYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLP-------AEWCEALHSFTAETSDDLSF 682

Query: 402 QKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIP 438
           ++G+ +++L +    W RG   +  R GIFP  +V P
Sbjct: 683 KRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 717



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 43/123 (34%), Positives = 64/123 (52%), Gaps = 9/123 (7%)

Query: 131 KALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSV-----EVIKQL 185
           +AL ++  +   DL F +GD I +  +LD +W +G +    G FPA  V     E    L
Sbjct: 667 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSML 726

Query: 186 PQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVGIFPIL 245
              P   +A   +D RG    EN+D L+F   DIIT +  VD++W  G+L  K GIFP  
Sbjct: 727 AIVPKGRKAKALYDFRG----ENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKN 782

Query: 246 FVE 248
           +++
Sbjct: 783 YIQ 785



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 22/55 (40%), Positives = 36/55 (65%)

Query: 129 RAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIK 183
           +AKAL ++RG+N  +L F  GDII     +D++W  GE+ G SG FP + ++ ++
Sbjct: 734 KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQ 788



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 59/256 (23%), Positives = 101/256 (39%), Gaps = 38/256 (14%)

Query: 244 ILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPGQFSITT 303
           +L V   +    ++ +N G  S +  ++ ++   +  N    ++G  + R    Q  I T
Sbjct: 414 MLSVPHGIANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIIT 473

Query: 304 ALNT-LNRMVHSPS-GRHMVEISTPVLIS------------SSNPSVITQPMEKADVP-- 347
            L+  L    + PS  +  V+   P  +             +     I   +EK D    
Sbjct: 474 PLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWY 533

Query: 348 -SSCVGQVSTYHPAPVSPGHSTAVVSLP----GSQQHLSANMF-----VALHSYSAHGPD 397
             +C  Q+  + PA     +   ++ +P    G ++ +S++       VA   Y     D
Sbjct: 534 RGNCRNQIGIF-PA----NYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKD 588

Query: 398 ELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSSFPDSRSPGLYTT 457
           EL   +GE + +     + W RG   V GR GIFP N+V P+      +P S +  L T 
Sbjct: 589 ELSFSEGEIIILKEYVNEEWARGE--VRGRTGIFPLNFVEPV----EDYPTSGANVLSTK 642

Query: 458 WTLSTSSVSSQGSISE 473
             L T    S GS S+
Sbjct: 643 VPLKTKKEDS-GSNSQ 657



 Score = 37.0 bits (84), Expect = 0.065
 Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 2/50 (4%)

Query: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           AL+ +     DEL  + G+ +  L    D W+ G   + G+ GIFP NY+
Sbjct: 737 ALYDFRGENEDELSFKAGDIITELESVDDDWMSGE--LMGKSGIFPKNYI 784



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 30/120 (25%), Positives = 50/120 (41%), Gaps = 26/120 (21%)

Query: 589 SEARIHSAASSLIMEDKEIPIKSEPLPKPPASAP-------------PSILVKPENSR-- 633
           +E   +S  S + + + +  I++  LPK P   P             PS+  KP  +R  
Sbjct: 6   TEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPAANRAS 65

Query: 634 ----NGIEKQVKTVRFQNYSP-PPTKHYTSHPTSGKPE-----QPATLKASQPEAASLGP 683
               +G E ++K    +  +P PP +   S P + KPE      P  +++  PE    GP
Sbjct: 66  GEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVT-KPELPKKPNPGLIRSVNPEIPGRGP 124


>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
           sapiens]
          Length = 816

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 80/293 (27%), Positives = 122/293 (41%), Gaps = 55/293 (18%)

Query: 170 ISGNFPASSVEVIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDEN 229
           I  ++  S+ E I++      +  A   FD + +   E    L   K DI+ +  ++D+N
Sbjct: 556 IPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKE----LPLQKGDIVYIYKQIDQN 611

Query: 230 WAEGKLGDKVGIFPILFVE----------PNLTARHLLEKNKGRQSSRTKNLSLVSSSSR 279
           W EG+   +VGIFP  ++E            LT   +LE  +          + V  S R
Sbjct: 612 WYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFR 671

Query: 280 -GNTSTLRRG----------PGSRRKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVL 328
            G   TL R           PG+ R+  G F IT                ++  I  P+ 
Sbjct: 672 KGERITLLRQVDENWYEGRIPGTSRQ--GIFPIT----------------YVDVIKRPL- 712

Query: 329 ISSSNPSVITQPMEKADVP-SSCVGQVSTYHPAPVSPGHSTAVVSLPGSQQHLSANMFVA 387
                   +  P++  D+P SS   + +T   +P  P      V+   SQ       + A
Sbjct: 713 --------VKNPVDYMDLPFSSSPSRSAT--ASPQQPQAQQRRVTPDRSQTSQDLFSYQA 762

Query: 388 LHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIF 440
           L+SY     DEL+L+ G+ V V+ KC DGW  G S  T + G FP NYV P++
Sbjct: 763 LYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 815



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 54/186 (29%), Positives = 98/186 (52%), Gaps = 23/186 (12%)

Query: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
           A+A  +++ Q   +L   KGDI+ + +Q+D+NWY+GE +G  G FP + +E++   +  Q
Sbjct: 580 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 639

Query: 188 PPPLC--------RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GD 237
           P  L          A+  F+  G  + E    ++F K + IT++ +VDENW EG++    
Sbjct: 640 PKKLTPVQVLEYGEAIAKFNFNGDTQVE----MSFRKGERITLLRQVDENWYEGRIPGTS 695

Query: 238 KVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPG 297
           + GIFPI +V+       ++++   +      +L   SS SR  T++ ++    +R+V  
Sbjct: 696 RQGIFPITYVD-------VIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTP 748

Query: 298 QFSITT 303
             S T+
Sbjct: 749 DRSQTS 754



 Score = 36.6 bits (83), Expect = 0.085
 Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 2/83 (2%)

Query: 100 RKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLD 159
           R +  +P++ QA   R+ P+       +   +AL +Y  QN  +L    GDI+ +  + D
Sbjct: 730 RSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 789

Query: 160 ENWYQGEINGIS--GNFPASSVE 180
           + W+ G        G FP + V+
Sbjct: 790 DGWFVGTSRRTKQFGTFPGNYVK 812



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 6/96 (6%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSS 445
           +A  +++     E+  +KGE + +L +  + W  G    T R GIFP  YV  I R    
Sbjct: 655 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR---- 710

Query: 446 FPDSRSPGLYTTWTLSTS-SVSSQGSISEGDPRQSR 480
            P  ++P  Y     S+S S S+  S  +   +Q R
Sbjct: 711 -PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 745


>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
           sapiens]
          Length = 684

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 80/293 (27%), Positives = 122/293 (41%), Gaps = 55/293 (18%)

Query: 170 ISGNFPASSVEVIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDEN 229
           I  ++  S+ E I++      +  A   FD + +   E    L   K DI+ +  ++D+N
Sbjct: 424 IPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKE----LPLQKGDIVYIYKQIDQN 479

Query: 230 WAEGKLGDKVGIFPILFVE----------PNLTARHLLEKNKGRQSSRTKNLSLVSSSSR 279
           W EG+   +VGIFP  ++E            LT   +LE  +          + V  S R
Sbjct: 480 WYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFR 539

Query: 280 -GNTSTLRRG----------PGSRRKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVL 328
            G   TL R           PG+ R+  G F IT                ++  I  P+ 
Sbjct: 540 KGERITLLRQVDENWYEGRIPGTSRQ--GIFPIT----------------YVDVIKRPL- 580

Query: 329 ISSSNPSVITQPMEKADVP-SSCVGQVSTYHPAPVSPGHSTAVVSLPGSQQHLSANMFVA 387
                   +  P++  D+P SS   + +T   +P  P      V+   SQ       + A
Sbjct: 581 --------VKNPVDYMDLPFSSSPSRSAT--ASPQQPQAQQRRVTPDRSQTSQDLFSYQA 630

Query: 388 LHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIF 440
           L+SY     DEL+L+ G+ V V+ KC DGW  G S  T + G FP NYV P++
Sbjct: 631 LYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 683



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 54/186 (29%), Positives = 98/186 (52%), Gaps = 23/186 (12%)

Query: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
           A+A  +++ Q   +L   KGDI+ + +Q+D+NWY+GE +G  G FP + +E++   +  Q
Sbjct: 448 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 507

Query: 188 PPPLC--------RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GD 237
           P  L          A+  F+  G  + E    ++F K + IT++ +VDENW EG++    
Sbjct: 508 PKKLTPVQVLEYGEAIAKFNFNGDTQVE----MSFRKGERITLLRQVDENWYEGRIPGTS 563

Query: 238 KVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPG 297
           + GIFPI +V+       ++++   +      +L   SS SR  T++ ++    +R+V  
Sbjct: 564 RQGIFPITYVD-------VIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTP 616

Query: 298 QFSITT 303
             S T+
Sbjct: 617 DRSQTS 622



 Score = 36.6 bits (83), Expect = 0.085
 Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 2/83 (2%)

Query: 100 RKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLD 159
           R +  +P++ QA   R+ P+       +   +AL +Y  QN  +L    GDI+ +  + D
Sbjct: 598 RSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 657

Query: 160 ENWYQGEINGIS--GNFPASSVE 180
           + W+ G        G FP + V+
Sbjct: 658 DGWFVGTSRRTKQFGTFPGNYVK 680



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 6/96 (6%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSS 445
           +A  +++     E+  +KGE + +L +  + W  G    T R GIFP  YV  I R    
Sbjct: 523 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR---- 578

Query: 446 FPDSRSPGLYTTWTLSTS-SVSSQGSISEGDPRQSR 480
            P  ++P  Y     S+S S S+  S  +   +Q R
Sbjct: 579 -PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 613


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 84/324 (25%), Positives = 135/324 (41%), Gaps = 60/324 (18%)

Query: 129  RAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIK----Q 184
            +A+ALC++  +    L F+K DII +  Q  ENW+ GE++G  G FP S V++I     +
Sbjct: 875  KAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVK 933

Query: 185  LPQPPPLCRALYNFDLR-----GKD-------KSENQDCLTFLKDDIITVISRVDENWAE 232
              +P  L  A+           G++        S     LTF + + I ++++ D  W  
Sbjct: 934  REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWT 992

Query: 233  GKLGDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSR 292
            G +GD+ GIFP  +V+P                   K+     S+S+          G+ 
Sbjct: 993  GSIGDRSGIFPSNYVKP-------------------KDQESFGSASKS---------GAS 1024

Query: 293  RKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVG 352
             K P    +T+A       V S S +  +     +LI   N S   Q   +A       G
Sbjct: 1025 NKKPEIAQVTSA------YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1078

Query: 353  QVSTYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGK 412
                 H   + P    A  +     Q       +A++ Y+A+  DEL   KG+ + V+ K
Sbjct: 1079 WFPASHVKLLGPSSERATPAFHPVCQ------VIAMYDYAANNEDELSFSKGQLINVMNK 1132

Query: 413  CQDGWLRGVSLVTGRVGIFPNNYV 436
                W +G   + G  G+FP+NYV
Sbjct: 1133 DDPDWWQGE--INGVTGLFPSNYV 1154



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 34/129 (26%), Positives = 63/129 (48%), Gaps = 14/129 (10%)

Query: 130  AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS-----GNFPASSVEVI-- 182
            A+    Y       L    G +IL+ ++    W+QGE+         G FPAS V+++  
Sbjct: 1031 AQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGP 1090

Query: 183  ---KQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKV 239
               +  P   P+C+ +  +D      + N+D L+F K  +I V+++ D +W +G++    
Sbjct: 1091 SSERATPAFHPVCQVIAMYDYA----ANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT 1146

Query: 240  GIFPILFVE 248
            G+FP  +V+
Sbjct: 1147 GLFPSNYVK 1155



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 23/68 (33%), Positives = 38/68 (55%)

Query: 132  ALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQLPQPPPL 191
            A+ +Y   N  +L F+KG +I +  + D +W+QGEING++G FP++ V++          
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQW 1166

Query: 192  CRALYNFD 199
            C  L   D
Sbjct: 1167 CADLQTLD 1174



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 75/327 (22%), Positives = 118/327 (36%), Gaps = 57/327 (17%)

Query: 193  RALYNFDLRGKDKSENQDCLTFLKDDIITVISRV--DENWAEGKLGDKVGIFPILFVEP- 249
            RALY F+ R      N D ++F   DII V  +   +  W  G      G FP  +VE  
Sbjct: 736  RALYPFEAR------NHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKM 789

Query: 250  ------------------------NLTARHLLEKNKGR-----QSSRTKNLSLVSSSSRG 280
                                      T+   L  N+       Q+    NL++ +S  + 
Sbjct: 790  PSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKK 849

Query: 281  NTSTLRRGPGSRRKVPGQFSITTALN-------TLNRMVHSPSGRHMVEISTPVLISSSN 333
            +  T    PGS   + GQ  +   L        T  +  H    +H +     VL    N
Sbjct: 850  SAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDI---ITVLEQQEN 906

Query: 334  PSVITQPMEKADVPSSCVGQVSTYHPAPVSPGHSTAVVSL-PGSQQHLSANMFVALHSYS 392
                     +   P S V  +         P    A V+  P S  +     ++AL+ YS
Sbjct: 907  WWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYS 966

Query: 393  AHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRK-----TSSFP 447
            +  P +L   +GE + V  K  + W   +     R GIFP+NYV P  ++     + S  
Sbjct: 967  SVEPGDLTFTEGEEILVTQKDGEWWTGSIG---DRSGIFPSNYVKPKDQESFGSASKSGA 1023

Query: 448  DSRSPGLYTTWTLSTSSVSSQGSISEG 474
             ++ P +    +   +S S Q S++ G
Sbjct: 1024 SNKKPEIAQVTSAYVASGSEQLSLAPG 1050


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 84/324 (25%), Positives = 135/324 (41%), Gaps = 60/324 (18%)

Query: 129  RAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIK----Q 184
            +A+ALC++  +    L F+K DII +  Q  ENW+ GE++G  G FP S V++I     +
Sbjct: 902  KAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960

Query: 185  LPQPPPLCRALYNFDLR-----GKD-------KSENQDCLTFLKDDIITVISRVDENWAE 232
              +P  L  A+           G++        S     LTF + + I ++++ D  W  
Sbjct: 961  REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWT 1019

Query: 233  GKLGDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSR 292
            G +GD+ GIFP  +V+P                   K+     S+S+          G+ 
Sbjct: 1020 GSIGDRSGIFPSNYVKP-------------------KDQESFGSASKS---------GAS 1051

Query: 293  RKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVG 352
             K P    +T+A       V S S +  +     +LI   N S   Q   +A       G
Sbjct: 1052 NKKPEIAQVTSA------YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1105

Query: 353  QVSTYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGK 412
                 H   + P    A  +     Q       +A++ Y+A+  DEL   KG+ + V+ K
Sbjct: 1106 WFPASHVKLLGPSSERATPAFHPVCQ------VIAMYDYAANNEDELSFSKGQLINVMNK 1159

Query: 413  CQDGWLRGVSLVTGRVGIFPNNYV 436
                W +G   + G  G+FP+NYV
Sbjct: 1160 DDPDWWQGE--INGVTGLFPSNYV 1181



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 34/129 (26%), Positives = 63/129 (48%), Gaps = 14/129 (10%)

Query: 130  AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS-----GNFPASSVEVI-- 182
            A+    Y       L    G +IL+ ++    W+QGE+         G FPAS V+++  
Sbjct: 1058 AQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGP 1117

Query: 183  ---KQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKV 239
               +  P   P+C+ +  +D      + N+D L+F K  +I V+++ D +W +G++    
Sbjct: 1118 SSERATPAFHPVCQVIAMYDYA----ANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT 1173

Query: 240  GIFPILFVE 248
            G+FP  +V+
Sbjct: 1174 GLFPSNYVK 1182



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 23/68 (33%), Positives = 38/68 (55%)

Query: 132  ALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQLPQPPPL 191
            A+ +Y   N  +L F+KG +I +  + D +W+QGEING++G FP++ V++          
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQW 1193

Query: 192  CRALYNFD 199
            C  L   D
Sbjct: 1194 CADLQTLD 1201



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 75/327 (22%), Positives = 118/327 (36%), Gaps = 57/327 (17%)

Query: 193  RALYNFDLRGKDKSENQDCLTFLKDDIITVISRV--DENWAEGKLGDKVGIFPILFVEP- 249
            RALY F+ R      N D ++F   DII V  +   +  W  G      G FP  +VE  
Sbjct: 763  RALYPFEAR------NHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKM 816

Query: 250  ------------------------NLTARHLLEKNKGR-----QSSRTKNLSLVSSSSRG 280
                                      T+   L  N+       Q+    NL++ +S  + 
Sbjct: 817  PSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKK 876

Query: 281  NTSTLRRGPGSRRKVPGQFSITTALN-------TLNRMVHSPSGRHMVEISTPVLISSSN 333
            +  T    PGS   + GQ  +   L        T  +  H    +H +     VL    N
Sbjct: 877  SAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDI---ITVLEQQEN 933

Query: 334  PSVITQPMEKADVPSSCVGQVSTYHPAPVSPGHSTAVVSL-PGSQQHLSANMFVALHSYS 392
                     +   P S V  +         P    A V+  P S  +     ++AL+ YS
Sbjct: 934  WWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYS 993

Query: 393  AHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRK-----TSSFP 447
            +  P +L   +GE + V  K  + W   +     R GIFP+NYV P  ++     + S  
Sbjct: 994  SVEPGDLTFTEGEEILVTQKDGEWWTGSIG---DRSGIFPSNYVKPKDQESFGSASKSGA 1050

Query: 448  DSRSPGLYTTWTLSTSSVSSQGSISEG 474
             ++ P +    +   +S S Q S++ G
Sbjct: 1051 SNKKPEIAQVTSAYVASGSEQLSLAPG 1077


>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
          Length = 1249

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 84/324 (25%), Positives = 135/324 (41%), Gaps = 60/324 (18%)

Query: 129  RAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIK----Q 184
            +A+ALC++  +    L F+K DII +  Q  ENW+ GE++G  G FP S V++I     +
Sbjct: 902  KAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960

Query: 185  LPQPPPLCRALYNFDLR-----GKD-------KSENQDCLTFLKDDIITVISRVDENWAE 232
              +P  L  A+           G++        S     LTF + + I ++++ D  W  
Sbjct: 961  REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWT 1019

Query: 233  GKLGDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSR 292
            G +GD+ GIFP  +V+P                   K+     S+S+          G+ 
Sbjct: 1020 GSIGDRSGIFPSNYVKP-------------------KDQESFGSASKS---------GAS 1051

Query: 293  RKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVG 352
             K P    +T+A       V S S +  +     +LI   N S   Q   +A       G
Sbjct: 1052 NKKPEIAQVTSA------YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1105

Query: 353  QVSTYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGK 412
                 H   + P    A  +     Q       +A++ Y+A+  DEL   KG+ + V+ K
Sbjct: 1106 WFPASHVKLLGPSSERATPAFHPVCQ------VIAMYDYAANNEDELSFSKGQLINVMNK 1159

Query: 413  CQDGWLRGVSLVTGRVGIFPNNYV 436
                W +G   + G  G+FP+NYV
Sbjct: 1160 DDPDWWQGE--INGVTGLFPSNYV 1181



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 34/129 (26%), Positives = 63/129 (48%), Gaps = 14/129 (10%)

Query: 130  AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS-----GNFPASSVEVI-- 182
            A+    Y       L    G +IL+ ++    W+QGE+         G FPAS V+++  
Sbjct: 1058 AQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGP 1117

Query: 183  ---KQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKV 239
               +  P   P+C+ +  +D      + N+D L+F K  +I V+++ D +W +G++    
Sbjct: 1118 SSERATPAFHPVCQVIAMYDYA----ANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT 1173

Query: 240  GIFPILFVE 248
            G+FP  +V+
Sbjct: 1174 GLFPSNYVK 1182



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 23/68 (33%), Positives = 38/68 (55%)

Query: 132  ALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQLPQPPPL 191
            A+ +Y   N  +L F+KG +I +  + D +W+QGEING++G FP++ V++          
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQW 1193

Query: 192  CRALYNFD 199
            C  L   D
Sbjct: 1194 CADLQTLD 1201



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 75/327 (22%), Positives = 118/327 (36%), Gaps = 57/327 (17%)

Query: 193  RALYNFDLRGKDKSENQDCLTFLKDDIITVISRV--DENWAEGKLGDKVGIFPILFVEP- 249
            RALY F+ R      N D ++F   DII V  +   +  W  G      G FP  +VE  
Sbjct: 763  RALYPFEAR------NHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKM 816

Query: 250  ------------------------NLTARHLLEKNKGR-----QSSRTKNLSLVSSSSRG 280
                                      T+   L  N+       Q+    NL++ +S  + 
Sbjct: 817  PSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKK 876

Query: 281  NTSTLRRGPGSRRKVPGQFSITTALN-------TLNRMVHSPSGRHMVEISTPVLISSSN 333
            +  T    PGS   + GQ  +   L        T  +  H    +H +     VL    N
Sbjct: 877  SAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDI---ITVLEQQEN 933

Query: 334  PSVITQPMEKADVPSSCVGQVSTYHPAPVSPGHSTAVVSL-PGSQQHLSANMFVALHSYS 392
                     +   P S V  +         P    A V+  P S  +     ++AL+ YS
Sbjct: 934  WWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYS 993

Query: 393  AHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRK-----TSSFP 447
            +  P +L   +GE + V  K  + W   +     R GIFP+NYV P  ++     + S  
Sbjct: 994  SVEPGDLTFTEGEEILVTQKDGEWWTGSIG---DRSGIFPSNYVKPKDQESFGSASKSGA 1050

Query: 448  DSRSPGLYTTWTLSTSSVSSQGSISEG 474
             ++ P +    +   +S S Q S++ G
Sbjct: 1051 SNKKPEIAQVTSAYVASGSEQLSLAPG 1077


>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
           sapiens]
          Length = 740

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 54/186 (29%), Positives = 98/186 (52%), Gaps = 23/186 (12%)

Query: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
           A+A  +++ Q   +L   KGDI+ + +Q+D+NWY+GE +G  G FP + +E++   +  Q
Sbjct: 504 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 563

Query: 188 PPPLC--------RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GD 237
           P  L          A+  F+  G  + E    ++F K + IT++ +VDENW EG++    
Sbjct: 564 PKKLTPVQVLEYGEAIAKFNFNGDTQVE----MSFRKGERITLLRQVDENWYEGRIPGTS 619

Query: 238 KVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPG 297
           + GIFPI +V+       ++++   +      +L   SS SR  T++ ++    +R+V  
Sbjct: 620 RQGIFPITYVD-------VIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTP 672

Query: 298 QFSITT 303
             S T+
Sbjct: 673 DRSQTS 678



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 75/265 (28%), Positives = 111/265 (41%), Gaps = 55/265 (20%)

Query: 198 FDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVGIFPILFVE--------- 248
           FD + +   E    L   K DI+ +  ++D+NW EG+   +VGIFP  ++E         
Sbjct: 508 FDFKAQTLKE----LPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 563

Query: 249 -PNLTARHLLEKNKGRQSSRTKNLSLVSSSSR-GNTSTLRRG----------PGSRRKVP 296
              LT   +LE  +          + V  S R G   TL R           PG+ R+  
Sbjct: 564 PKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ-- 621

Query: 297 GQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVP-SSCVGQVS 355
           G F IT                ++  I  P+         +  P++  D+P SS   + +
Sbjct: 622 GIFPIT----------------YVDVIKRPL---------VKNPVDYMDLPFSSSPSRSA 656

Query: 356 TYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQD 415
           T   +P  P      V+   SQ       + AL+SY     DEL+L+ G+ V V+ KC D
Sbjct: 657 T--ASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDD 714

Query: 416 GWLRGVSLVTGRVGIFPNNYVIPIF 440
           GW  G S  T + G FP NYV P++
Sbjct: 715 GWFVGTSRRTKQFGTFPGNYVKPLY 739



 Score = 36.6 bits (83), Expect = 0.085
 Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 2/83 (2%)

Query: 100 RKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLD 159
           R +  +P++ QA   R+ P+       +   +AL +Y  QN  +L    GDI+ +  + D
Sbjct: 654 RSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 713

Query: 160 ENWYQGEINGIS--GNFPASSVE 180
           + W+ G        G FP + V+
Sbjct: 714 DGWFVGTSRRTKQFGTFPGNYVK 736



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 6/96 (6%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSS 445
           +A  +++     E+  +KGE + +L +  + W  G    T R GIFP  YV  I R    
Sbjct: 579 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR---- 634

Query: 446 FPDSRSPGLYTTWTLSTS-SVSSQGSISEGDPRQSR 480
            P  ++P  Y     S+S S S+  S  +   +Q R
Sbjct: 635 -PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 669



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 2/50 (4%)

Query: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           A   + A    EL LQKG+ V +  +    W  G     GRVGIFP  Y+
Sbjct: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH--HGRVGIFPRTYI 553


>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
           sapiens]
          Length = 781

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 54/186 (29%), Positives = 98/186 (52%), Gaps = 23/186 (12%)

Query: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
           A+A  +++ Q   +L   KGDI+ + +Q+D+NWY+GE +G  G FP + +E++   +  Q
Sbjct: 545 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 604

Query: 188 PPPLC--------RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GD 237
           P  L          A+  F+  G  + E    ++F K + IT++ +VDENW EG++    
Sbjct: 605 PKKLTPVQVLEYGEAIAKFNFNGDTQVE----MSFRKGERITLLRQVDENWYEGRIPGTS 660

Query: 238 KVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPG 297
           + GIFPI +V+       ++++   +      +L   SS SR  T++ ++    +R+V  
Sbjct: 661 RQGIFPITYVD-------VIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTP 713

Query: 298 QFSITT 303
             S T+
Sbjct: 714 DRSQTS 719



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 75/265 (28%), Positives = 111/265 (41%), Gaps = 55/265 (20%)

Query: 198 FDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVGIFPILFVE--------- 248
           FD + +   E    L   K DI+ +  ++D+NW EG+   +VGIFP  ++E         
Sbjct: 549 FDFKAQTLKE----LPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 604

Query: 249 -PNLTARHLLEKNKGRQSSRTKNLSLVSSSSR-GNTSTLRRG----------PGSRRKVP 296
              LT   +LE  +          + V  S R G   TL R           PG+ R+  
Sbjct: 605 PKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ-- 662

Query: 297 GQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVP-SSCVGQVS 355
           G F IT                ++  I  P+         +  P++  D+P SS   + +
Sbjct: 663 GIFPIT----------------YVDVIKRPL---------VKNPVDYMDLPFSSSPSRSA 697

Query: 356 TYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQD 415
           T   +P  P      V+   SQ       + AL+SY     DEL+L+ G+ V V+ KC D
Sbjct: 698 T--ASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDD 755

Query: 416 GWLRGVSLVTGRVGIFPNNYVIPIF 440
           GW  G S  T + G FP NYV P++
Sbjct: 756 GWFVGTSRRTKQFGTFPGNYVKPLY 780



 Score = 36.6 bits (83), Expect = 0.085
 Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 2/83 (2%)

Query: 100 RKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLD 159
           R +  +P++ QA   R+ P+       +   +AL +Y  QN  +L    GDI+ +  + D
Sbjct: 695 RSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 754

Query: 160 ENWYQGEINGIS--GNFPASSVE 180
           + W+ G        G FP + V+
Sbjct: 755 DGWFVGTSRRTKQFGTFPGNYVK 777



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 6/96 (6%)

Query: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSS 445
           +A  +++     E+  +KGE + +L +  + W  G    T R GIFP  YV  I R    
Sbjct: 620 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR---- 675

Query: 446 FPDSRSPGLYTTWTLSTS-SVSSQGSISEGDPRQSR 480
            P  ++P  Y     S+S S S+  S  +   +Q R
Sbjct: 676 -PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 710



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 2/50 (4%)

Query: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
           A   + A    EL LQKG+ V +  +    W  G     GRVGIFP  Y+
Sbjct: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH--HGRVGIFPRTYI 594


>gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens]
          Length = 368

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 31/60 (51%), Positives = 43/60 (71%)

Query: 128 PRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQLPQ 187
           P  KAL ++  +N G+L F++GD+I L  Q+DENWY+G ++G SG FP S VEV+  LPQ
Sbjct: 309 PSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVLVPLPQ 368



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 26/63 (41%), Positives = 38/63 (60%), Gaps = 6/63 (9%)

Query: 186 PQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVGIFPIL 245
           P   P C+ALY+F+       EN   L F + D+IT+ +++DENW EG L  + G FP+ 
Sbjct: 305 PLDQPSCKALYDFE------PENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLS 358

Query: 246 FVE 248
           +VE
Sbjct: 359 YVE 361


>gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens]
          Length = 347

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 31/60 (51%), Positives = 41/60 (68%)

Query: 128 PRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQLPQ 187
           P  + L ++  +N G+L F +GDII L  Q+DENWY+G I+G SG FP + VEVI  LPQ
Sbjct: 288 PCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLPQ 347



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 34/87 (39%), Positives = 49/87 (56%), Gaps = 16/87 (18%)

Query: 166 EINGISGNFPASSVEVIK----QLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIIT 221
           E+NG+S      +  V+K     +P   P CR LY+F+       ENQ  L F + DIIT
Sbjct: 266 ELNGVS------TTSVVKTTGSNIPMDQPCCRGLYDFE------PENQGELGFKEGDIIT 313

Query: 222 VISRVDENWAEGKLGDKVGIFPILFVE 248
           + +++DENW EG +  + G FPI +VE
Sbjct: 314 LTNQIDENWYEGMIHGESGFFPINYVE 340


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,019,322
Number of Sequences: 37866
Number of extensions: 1691399
Number of successful extensions: 8499
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 223
Number of HSP's successfully gapped in prelim test: 442
Number of HSP's that attempted gapping in prelim test: 6994
Number of HSP's gapped (non-prelim): 1739
length of query: 729
length of database: 18,247,518
effective HSP length: 110
effective length of query: 619
effective length of database: 14,082,258
effective search space: 8716917702
effective search space used: 8716917702
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.