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Search of human proteins with 222418793
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222418793 EF-hand calcium binding domain 4B isoform b [Homo
sapiens]
(462 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222418793 EF-hand calcium binding domain 4B isoform b [Homo s... 924 0.0
gi|222418791 EF-hand calcium binding domain 4B isoform a [Homo s... 843 0.0
gi|14249254 EF-hand calcium binding domain 4B isoform c [Homo sa... 743 0.0
gi|150170653 EF-hand calcium binding domain 4A [Homo sapiens] 142 5e-34
gi|40255119 RAS and EF-hand domain containing [Homo sapiens] 96 7e-20
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 73 6e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 73 6e-13
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 73 6e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 73 6e-13
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 72 1e-12
gi|42794779 myosin 18A isoform b [Homo sapiens] 69 7e-12
gi|28416946 myosin 18A isoform a [Homo sapiens] 69 7e-12
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 69 1e-11
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 69 1e-11
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 69 1e-11
gi|148746195 trichohyalin [Homo sapiens] 68 2e-11
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 67 3e-11
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 62 8e-10
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 62 8e-10
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 61 2e-09
gi|16262452 cingulin [Homo sapiens] 61 2e-09
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 61 2e-09
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 61 2e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 61 2e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 61 2e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 61 2e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 61 2e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 61 2e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 61 2e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 61 2e-09
>gi|222418793 EF-hand calcium binding domain 4B isoform b [Homo
sapiens]
Length = 462
Score = 924 bits (2389), Expect = 0.0
Identities = 462/462 (100%), Positives = 462/462 (100%)
Query: 1 MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ 60
MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ
Sbjct: 1 MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ 60
Query: 61 TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ 120
TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ
Sbjct: 61 TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ 120
Query: 121 NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK
Sbjct: 121 NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
Query: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM
Sbjct: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
Query: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE
Sbjct: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR
Sbjct: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
Query: 361 EKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKRSGSVIGKYVDSRG 420
EKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKRSGSVIGKYVDSRG
Sbjct: 361 EKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKRSGSVIGKYVDSRG 420
Query: 421 ILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKKICKAEVTLEM 462
ILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKKICKAEVTLEM
Sbjct: 421 ILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKKICKAEVTLEM 462
>gi|222418791 EF-hand calcium binding domain 4B isoform a [Homo
sapiens]
Length = 731
Score = 843 bits (2177), Expect = 0.0
Identities = 426/436 (97%), Positives = 428/436 (98%), Gaps = 3/436 (0%)
Query: 1 MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ 60
MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ
Sbjct: 1 MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ 60
Query: 61 TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ 120
TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ
Sbjct: 61 TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ 120
Query: 121 NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK
Sbjct: 121 NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
Query: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM
Sbjct: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
Query: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE
Sbjct: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR
Sbjct: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
Query: 361 EKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKRSGSVIGKYVDSRG 420
EKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKRSGSVIGKYVDSRG
Sbjct: 361 EKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKRSGSVIGKYVDSRG 420
Query: 421 ILRRWPQRDR---GIP 433
ILR + + GIP
Sbjct: 421 ILRSQSEEEEEVFGIP 436
>gi|14249254 EF-hand calcium binding domain 4B isoform c [Homo
sapiens]
Length = 395
Score = 743 bits (1917), Expect = 0.0
Identities = 373/373 (100%), Positives = 373/373 (100%)
Query: 1 MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ 60
MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ
Sbjct: 1 MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ 60
Query: 61 TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ 120
TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ
Sbjct: 61 TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ 120
Query: 121 NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK
Sbjct: 121 NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
Query: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM
Sbjct: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
Query: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE
Sbjct: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR
Sbjct: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
Query: 361 EKAGLLKQLDFLR 373
EKAGLLKQLDFLR
Sbjct: 361 EKAGLLKQLDFLR 373
>gi|150170653 EF-hand calcium binding domain 4A [Homo sapiens]
Length = 294
Score = 142 bits (359), Expect = 5e-34
Identities = 92/276 (33%), Positives = 153/276 (55%), Gaps = 14/276 (5%)
Query: 37 EQKETQEQTSG-QLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDA 95
E+ E + ++G + +L +A+E F CD E KGFI + D+Q L +LPL+ E+LE VF++
Sbjct: 15 EEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQLEAVFES 74
Query: 96 LDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMG-- 153
LD G+LT +EF G F + R E+ + S G + G G
Sbjct: 75 LDRAHTGFLTAREFCLGLGMFVGVASAQGANPC------RTPEETFESGGLDVQGTAGSL 128
Query: 154 ---EDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQE 210
E+EE +F ++++LG VL + V+ LW +L++E P LL +FED L R + L+E
Sbjct: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
Query: 211 AHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKL 270
A E++ LE AL+R+ + ++ E++ LYEE E Q++ + + ++ R + RS+ LE +L
Sbjct: 189 AARERDGLEQALRRRESEHEREVRALYEETE-QLREQSRRPPSQNFARGERRSR-LELEL 246
Query: 271 LCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENT 306
+EQ+LE+ +Q+ G+ H ++ A T
Sbjct: 247 QSREQDLERAGLRQRERRGRRLQEHAERESQPATAT 282
>gi|40255119 RAS and EF-hand domain containing [Homo sapiens]
Length = 740
Score = 95.9 bits (237), Expect = 7e-20
Identities = 82/353 (23%), Positives = 157/353 (44%), Gaps = 28/353 (7%)
Query: 52 LRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTT 111
L + + F CDA G + R++ + L EL + + E VF LDAD +G +T QEF
Sbjct: 10 LARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFAR 69
Query: 112 GFSHFFFSQNN---------PSQEDAGEQVAQRHEEKVYLSRGDEDLG-----DMGEDEE 157
GF P+ +AG + E++ GDED G
Sbjct: 70 GFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDE-----GDEDAAAALATSCGPASP 124
Query: 158 AQ-FRMLMDRLGAQ-KVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEK 215
+ ++ RLG + K + E V L+ + EP L+ +E + I +++ E
Sbjct: 125 GRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEM 184
Query: 216 NELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQ 275
L A+KR ++ L EEM+Q+I++ + + + + + +L ++ +
Sbjct: 185 ENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYETEVG 244
Query: 276 ELEQLTQKQKRLEGQC--TALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQL 333
+L+ +K ++LE Q + D K + L + NQ++ ++L + Q +L
Sbjct: 245 DLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSEL 304
Query: 334 ESLQQEAC--KLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERD 384
++L+ + L+ E+++E+ R + ++ L +Q++ L+ N+ L D D
Sbjct: 305 DALKSDYADQSLNTERDLEIIR---AYTEDRNSLERQIEILQTANRKLHDSND 354
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 72.8 bits (177), Expect = 6e-13
Identities = 90/391 (23%), Positives = 162/391 (41%), Gaps = 35/391 (8%)
Query: 33 LDSLEQKETQEQTSGQLVM--LRKAQEFFQTCDAEGKGFIARK-DMQRLHKELPLSLEEL 89
L LEQK +Q L+ L+ E + + A+K +++ + E+ LEE
Sbjct: 875 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 934
Query: 90 EDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDL 149
ED L A+ + +E+A Q Q EKV + L
Sbjct: 935 EDRGQQLQAERKKMA---------QQMLDLEEQLEEEEAARQKLQL--EKVTAEAKIKKL 983
Query: 150 GDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPH------LLSNFEDFLTR 203
EDE ++L ++ L +E + L L +EE L + E ++
Sbjct: 984 ----EDEILVMDDQNNKLSKERKLLEER-ISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1038
Query: 204 IISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARS 263
+ +L++ + + ELE LKRK+ + +++ QI K Q L K E QA
Sbjct: 1039 LEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQ-LAKKEEELQAAL 1096
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTS 323
L+ ++ K L+++ + LEG + L D +A K + ++L ELE
Sbjct: 1097 ARLDDEIAQKNNALKKI----RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1152
Query: 324 WELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDER 383
EL+D + Q+ L ++E EV + ++L E Q+ +R+++ +E
Sbjct: 1153 TELEDTLDSTATQQE----LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208
Query: 384 DICFQKNKAAKANTAASRASWKKRSGSVIGK 414
++ K AKAN ++ + +K + + G+
Sbjct: 1209 TEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Score = 55.5 bits (132), Expect = 1e-07
Identities = 86/401 (21%), Positives = 165/401 (41%), Gaps = 56/401 (13%)
Query: 34 DSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFI----ARKDMQRLHKELPLSLEEL 89
++LE KE E+T+ L + ++ + D GK +++ ++ +E+ LEEL
Sbjct: 1494 EALEAKEELERTNKMLKA--EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 90 EDVFDAL-DADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDED 148
ED A DA + Q F +++ ++E + Q HE + L
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL------ 1605
Query: 149 LGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQL------KKEEPHLLSNFEDFLT 202
EDE Q + A+K LE D+K L LQ ++E L + +
Sbjct: 1606 -----EDERKQRALAA---AAKKKLE--GDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 203 RIISQLQEAHEEKNELECALK---RKIAAYDEEIQHLYEEM------EQQIKSEKEQF-- 251
+L++A ++E+ K +K + + ++ L E++ +Q EKE+
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1715
Query: 252 -----------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
L + R +AR +LE++L ++ +E ++ + ++ Q L ++
Sbjct: 1716 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1775
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
++ K + Q+L R+ + +L + + ++S + + K ++ E R
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 361 EKAGLLKQL----DFLRERNKHLRDERDICFQ-KNKAAKAN 396
EK K L L+E + DER + Q K +A K N
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1876
Score = 50.1 bits (118), Expect = 4e-06
Identities = 52/273 (19%), Positives = 121/273 (44%), Gaps = 22/273 (8%)
Query: 131 QVAQRHEE-KVYLSRGDEDLGDMGE------DEEAQFRMLMDRLGAQKVLEDESDVKQLW 183
Q+A++ EE + L+R D+++ + E L + L +++ ++++ ++
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR- 1142
Query: 184 LQLKKEEPHLLSNFEDFLTRIISQLQ---EAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
L +E L + ED L +Q + + +E L+ AL + +++ ++Q + ++
Sbjct: 1143 -DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 241 EQQIKSEKEQF---------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQC 291
Q ++ EQ L K+ + + + +L +L Q +++ K+K+LE Q
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1261
Query: 292 TALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEV 351
L + + +L +L E+E + L +A+ + L ++ L + + +
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ-DT 1320
Query: 352 YRVTESLQREKAGLLKQLDFLRERNKHLRDERD 384
+ + R+K + +L L E L+D+ D
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1353
Score = 45.4 bits (106), Expect = 1e-04
Identities = 89/409 (21%), Positives = 164/409 (40%), Gaps = 53/409 (12%)
Query: 63 DAEGKGFIARKDMQRLHKELPLSLEEL-EDVFDALDADGNGYLTPQEFTTGFSHFFFSQN 121
+AEGK KD+ L +L + E L E+ L+ +E + Q+
Sbjct: 1298 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS-------LQD 1350
Query: 122 NPSQEDAGEQVAQRHEE--KVYLSRGDEDLGDMGEDEEA------QFRMLMDRLGAQKVL 173
+E +Q +RH + LS + L D EA +F+ ++ L Q
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY-- 1408
Query: 174 EDESDVKQLWLQLKKEEPHLLSNFEDFLT------RIISQLQEAHEEKNELECALKRKIA 227
+ + +L+K + L +D + +++S L++ + ++L K +
Sbjct: 1409 ---EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
Y +E E E + K K L + E +ELE+ + E+E L + +
Sbjct: 1466 KYADERDRA--EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK 347
L K + + ++K +EL EL+ T +DA+ +LE + +A K E+
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQAT----EDAKLRLE-VNMQALKGQFER 1578
Query: 348 EMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKR 407
+++ E + ++ L +Q L E L DER K +A A A+ KK
Sbjct: 1579 DLQAR--DEQNEEKRRQLQRQ---LHEYETELEDER-----KQRALAA------AAKKKL 1622
Query: 408 SGSVIGKYVDSRGILRRWPQRDRGIPTLQYQT---QRDLEDCKHEMKKI 453
G + + + ++ + + + LQ Q QR+LED + +I
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Score = 44.7 bits (104), Expect = 2e-04
Identities = 39/178 (21%), Positives = 85/178 (47%), Gaps = 6/178 (3%)
Query: 171 KVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHE---EKNELECALKRKIA 227
KV + +++V+ + L + E + +D + + SQLQ+ E E+ + + K+
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKD-VASLSSQLQDTQELLQEETRQKLNVSTKLR 1339
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
+EE L +++++++ E +Q L + + + ++KL +E L + +KR
Sbjct: 1340 QLEEERNSLQDQLDEEM--EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQ 345
+ + L E A KL+ T L +EL+ +L + +Q + +L+++ K Q
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Score = 43.1 bits (100), Expect = 5e-04
Identities = 42/158 (26%), Positives = 74/158 (46%), Gaps = 10/158 (6%)
Query: 243 QIKSEKEQFLLKDTE--RFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
Q+ ++E+ K+ E + + R Q+ E +L EQ+ QLT+++ L+ Q A E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
+ +L QEL L L++ + + + LQ E K+ Q ++ + E L+
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ----QMLDLEEQLEE 961
Query: 361 EKAGLLK-QLDFLRERNKHLRDERDICF---QKNKAAK 394
E+A K QL+ + K + E +I Q NK +K
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 999
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 72.8 bits (177), Expect = 6e-13
Identities = 90/391 (23%), Positives = 162/391 (41%), Gaps = 35/391 (8%)
Query: 33 LDSLEQKETQEQTSGQLVM--LRKAQEFFQTCDAEGKGFIARK-DMQRLHKELPLSLEEL 89
L LEQK +Q L+ L+ E + + A+K +++ + E+ LEE
Sbjct: 882 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 941
Query: 90 EDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDL 149
ED L A+ + +E+A Q Q EKV + L
Sbjct: 942 EDRGQQLQAERKKMA---------QQMLDLEEQLEEEEAARQKLQL--EKVTAEAKIKKL 990
Query: 150 GDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPH------LLSNFEDFLTR 203
EDE ++L ++ L +E + L L +EE L + E ++
Sbjct: 991 ----EDEILVMDDQNNKLSKERKLLEER-ISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1045
Query: 204 IISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARS 263
+ +L++ + + ELE LKRK+ + +++ QI K Q L K E QA
Sbjct: 1046 LEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQ-LAKKEEELQAAL 1103
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTS 323
L+ ++ K L+++ + LEG + L D +A K + ++L ELE
Sbjct: 1104 ARLDDEIAQKNNALKKI----RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1159
Query: 324 WELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDER 383
EL+D + Q+ L ++E EV + ++L E Q+ +R+++ +E
Sbjct: 1160 TELEDTLDSTATQQE----LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215
Query: 384 DICFQKNKAAKANTAASRASWKKRSGSVIGK 414
++ K AKAN ++ + +K + + G+
Sbjct: 1216 TEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Score = 55.5 bits (132), Expect = 1e-07
Identities = 86/401 (21%), Positives = 165/401 (41%), Gaps = 56/401 (13%)
Query: 34 DSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFI----ARKDMQRLHKELPLSLEEL 89
++LE KE E+T+ L + ++ + D GK +++ ++ +E+ LEEL
Sbjct: 1501 EALEAKEELERTNKMLKA--EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 90 EDVFDAL-DADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDED 148
ED A DA + Q F +++ ++E + Q HE + L
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL------ 1612
Query: 149 LGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQL------KKEEPHLLSNFEDFLT 202
EDE Q + A+K LE D+K L LQ ++E L + +
Sbjct: 1613 -----EDERKQRALAA---AAKKKLE--GDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 203 RIISQLQEAHEEKNELECALK---RKIAAYDEEIQHLYEEM------EQQIKSEKEQF-- 251
+L++A ++E+ K +K + + ++ L E++ +Q EKE+
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1722
Query: 252 -----------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
L + R +AR +LE++L ++ +E ++ + ++ Q L ++
Sbjct: 1723 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
++ K + Q+L R+ + +L + + ++S + + K ++ E R
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 361 EKAGLLKQL----DFLRERNKHLRDERDICFQ-KNKAAKAN 396
EK K L L+E + DER + Q K +A K N
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883
Score = 50.1 bits (118), Expect = 4e-06
Identities = 52/273 (19%), Positives = 121/273 (44%), Gaps = 22/273 (8%)
Query: 131 QVAQRHEE-KVYLSRGDEDLGDMGE------DEEAQFRMLMDRLGAQKVLEDESDVKQLW 183
Q+A++ EE + L+R D+++ + E L + L +++ ++++ ++
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR- 1149
Query: 184 LQLKKEEPHLLSNFEDFLTRIISQLQ---EAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
L +E L + ED L +Q + + +E L+ AL + +++ ++Q + ++
Sbjct: 1150 -DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 241 EQQIKSEKEQF---------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQC 291
Q ++ EQ L K+ + + + +L +L Q +++ K+K+LE Q
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1268
Query: 292 TALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEV 351
L + + +L +L E+E + L +A+ + L ++ L + + +
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ-DT 1327
Query: 352 YRVTESLQREKAGLLKQLDFLRERNKHLRDERD 384
+ + R+K + +L L E L+D+ D
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1360
Score = 45.4 bits (106), Expect = 1e-04
Identities = 89/409 (21%), Positives = 164/409 (40%), Gaps = 53/409 (12%)
Query: 63 DAEGKGFIARKDMQRLHKELPLSLEEL-EDVFDALDADGNGYLTPQEFTTGFSHFFFSQN 121
+AEGK KD+ L +L + E L E+ L+ +E + Q+
Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS-------LQD 1357
Query: 122 NPSQEDAGEQVAQRHEE--KVYLSRGDEDLGDMGEDEEA------QFRMLMDRLGAQKVL 173
+E +Q +RH + LS + L D EA +F+ ++ L Q
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY-- 1415
Query: 174 EDESDVKQLWLQLKKEEPHLLSNFEDFLT------RIISQLQEAHEEKNELECALKRKIA 227
+ + +L+K + L +D + +++S L++ + ++L K +
Sbjct: 1416 ---EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
Y +E E E + K K L + E +ELE+ + E+E L + +
Sbjct: 1473 KYADERDRA--EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK 347
L K + + ++K +EL EL+ T +DA+ +LE + +A K E+
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQAT----EDAKLRLE-VNMQALKGQFER 1585
Query: 348 EMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKR 407
+++ E + ++ L +Q L E L DER K +A A A+ KK
Sbjct: 1586 DLQAR--DEQNEEKRRQLQRQ---LHEYETELEDER-----KQRALAA------AAKKKL 1629
Query: 408 SGSVIGKYVDSRGILRRWPQRDRGIPTLQYQT---QRDLEDCKHEMKKI 453
G + + + ++ + + + LQ Q QR+LED + +I
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Score = 44.7 bits (104), Expect = 2e-04
Identities = 39/178 (21%), Positives = 85/178 (47%), Gaps = 6/178 (3%)
Query: 171 KVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHE---EKNELECALKRKIA 227
KV + +++V+ + L + E + +D + + SQLQ+ E E+ + + K+
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKD-VASLSSQLQDTQELLQEETRQKLNVSTKLR 1346
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
+EE L +++++++ E +Q L + + + ++KL +E L + +KR
Sbjct: 1347 QLEEERNSLQDQLDEEM--EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQ 345
+ + L E A KL+ T L +EL+ +L + +Q + +L+++ K Q
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Score = 43.1 bits (100), Expect = 5e-04
Identities = 42/158 (26%), Positives = 74/158 (46%), Gaps = 10/158 (6%)
Query: 243 QIKSEKEQFLLKDTE--RFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
Q+ ++E+ K+ E + + R Q+ E +L EQ+ QLT+++ L+ Q A E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
+ +L QEL L L++ + + + LQ E K+ Q ++ + E L+
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ----QMLDLEEQLEE 968
Query: 361 EKAGLLK-QLDFLRERNKHLRDERDICF---QKNKAAK 394
E+A K QL+ + K + E +I Q NK +K
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 1006
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 72.8 bits (177), Expect = 6e-13
Identities = 90/391 (23%), Positives = 162/391 (41%), Gaps = 35/391 (8%)
Query: 33 LDSLEQKETQEQTSGQLVM--LRKAQEFFQTCDAEGKGFIARK-DMQRLHKELPLSLEEL 89
L LEQK +Q L+ L+ E + + A+K +++ + E+ LEE
Sbjct: 882 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 941
Query: 90 EDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDL 149
ED L A+ + +E+A Q Q EKV + L
Sbjct: 942 EDRGQQLQAERKKMA---------QQMLDLEEQLEEEEAARQKLQL--EKVTAEAKIKKL 990
Query: 150 GDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPH------LLSNFEDFLTR 203
EDE ++L ++ L +E + L L +EE L + E ++
Sbjct: 991 ----EDEILVMDDQNNKLSKERKLLEER-ISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1045
Query: 204 IISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARS 263
+ +L++ + + ELE LKRK+ + +++ QI K Q L K E QA
Sbjct: 1046 LEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQ-LAKKEEELQAAL 1103
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTS 323
L+ ++ K L+++ + LEG + L D +A K + ++L ELE
Sbjct: 1104 ARLDDEIAQKNNALKKI----RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1159
Query: 324 WELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDER 383
EL+D + Q+ L ++E EV + ++L E Q+ +R+++ +E
Sbjct: 1160 TELEDTLDSTATQQE----LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215
Query: 384 DICFQKNKAAKANTAASRASWKKRSGSVIGK 414
++ K AKAN ++ + +K + + G+
Sbjct: 1216 TEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Score = 55.5 bits (132), Expect = 1e-07
Identities = 86/401 (21%), Positives = 165/401 (41%), Gaps = 56/401 (13%)
Query: 34 DSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFI----ARKDMQRLHKELPLSLEEL 89
++LE KE E+T+ L + ++ + D GK +++ ++ +E+ LEEL
Sbjct: 1501 EALEAKEELERTNKMLKA--EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 90 EDVFDAL-DADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDED 148
ED A DA + Q F +++ ++E + Q HE + L
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL------ 1612
Query: 149 LGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQL------KKEEPHLLSNFEDFLT 202
EDE Q + A+K LE D+K L LQ ++E L + +
Sbjct: 1613 -----EDERKQRALAA---AAKKKLE--GDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 203 RIISQLQEAHEEKNELECALK---RKIAAYDEEIQHLYEEM------EQQIKSEKEQF-- 251
+L++A ++E+ K +K + + ++ L E++ +Q EKE+
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1722
Query: 252 -----------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
L + R +AR +LE++L ++ +E ++ + ++ Q L ++
Sbjct: 1723 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
++ K + Q+L R+ + +L + + ++S + + K ++ E R
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 361 EKAGLLKQL----DFLRERNKHLRDERDICFQ-KNKAAKAN 396
EK K L L+E + DER + Q K +A K N
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883
Score = 50.1 bits (118), Expect = 4e-06
Identities = 52/273 (19%), Positives = 121/273 (44%), Gaps = 22/273 (8%)
Query: 131 QVAQRHEE-KVYLSRGDEDLGDMGE------DEEAQFRMLMDRLGAQKVLEDESDVKQLW 183
Q+A++ EE + L+R D+++ + E L + L +++ ++++ ++
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR- 1149
Query: 184 LQLKKEEPHLLSNFEDFLTRIISQLQ---EAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
L +E L + ED L +Q + + +E L+ AL + +++ ++Q + ++
Sbjct: 1150 -DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 241 EQQIKSEKEQF---------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQC 291
Q ++ EQ L K+ + + + +L +L Q +++ K+K+LE Q
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1268
Query: 292 TALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEV 351
L + + +L +L E+E + L +A+ + L ++ L + + +
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ-DT 1327
Query: 352 YRVTESLQREKAGLLKQLDFLRERNKHLRDERD 384
+ + R+K + +L L E L+D+ D
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1360
Score = 45.4 bits (106), Expect = 1e-04
Identities = 89/409 (21%), Positives = 164/409 (40%), Gaps = 53/409 (12%)
Query: 63 DAEGKGFIARKDMQRLHKELPLSLEEL-EDVFDALDADGNGYLTPQEFTTGFSHFFFSQN 121
+AEGK KD+ L +L + E L E+ L+ +E + Q+
Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS-------LQD 1357
Query: 122 NPSQEDAGEQVAQRHEE--KVYLSRGDEDLGDMGEDEEA------QFRMLMDRLGAQKVL 173
+E +Q +RH + LS + L D EA +F+ ++ L Q
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY-- 1415
Query: 174 EDESDVKQLWLQLKKEEPHLLSNFEDFLT------RIISQLQEAHEEKNELECALKRKIA 227
+ + +L+K + L +D + +++S L++ + ++L K +
Sbjct: 1416 ---EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
Y +E E E + K K L + E +ELE+ + E+E L + +
Sbjct: 1473 KYADERDRA--EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK 347
L K + + ++K +EL EL+ T +DA+ +LE + +A K E+
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQAT----EDAKLRLE-VNMQALKGQFER 1585
Query: 348 EMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKR 407
+++ E + ++ L +Q L E L DER K +A A A+ KK
Sbjct: 1586 DLQAR--DEQNEEKRRQLQRQ---LHEYETELEDER-----KQRALAA------AAKKKL 1629
Query: 408 SGSVIGKYVDSRGILRRWPQRDRGIPTLQYQT---QRDLEDCKHEMKKI 453
G + + + ++ + + + LQ Q QR+LED + +I
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Score = 44.7 bits (104), Expect = 2e-04
Identities = 39/178 (21%), Positives = 85/178 (47%), Gaps = 6/178 (3%)
Query: 171 KVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHE---EKNELECALKRKIA 227
KV + +++V+ + L + E + +D + + SQLQ+ E E+ + + K+
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKD-VASLSSQLQDTQELLQEETRQKLNVSTKLR 1346
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
+EE L +++++++ E +Q L + + + ++KL +E L + +KR
Sbjct: 1347 QLEEERNSLQDQLDEEM--EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQ 345
+ + L E A KL+ T L +EL+ +L + +Q + +L+++ K Q
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Score = 43.1 bits (100), Expect = 5e-04
Identities = 42/158 (26%), Positives = 74/158 (46%), Gaps = 10/158 (6%)
Query: 243 QIKSEKEQFLLKDTE--RFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
Q+ ++E+ K+ E + + R Q+ E +L EQ+ QLT+++ L+ Q A E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
+ +L QEL L L++ + + + LQ E K+ Q ++ + E L+
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ----QMLDLEEQLEE 968
Query: 361 EKAGLLK-QLDFLRERNKHLRDERDICF---QKNKAAK 394
E+A K QL+ + K + E +I Q NK +K
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 1006
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 72.8 bits (177), Expect = 6e-13
Identities = 90/391 (23%), Positives = 162/391 (41%), Gaps = 35/391 (8%)
Query: 33 LDSLEQKETQEQTSGQLVM--LRKAQEFFQTCDAEGKGFIARK-DMQRLHKELPLSLEEL 89
L LEQK +Q L+ L+ E + + A+K +++ + E+ LEE
Sbjct: 875 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 934
Query: 90 EDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDL 149
ED L A+ + +E+A Q Q EKV + L
Sbjct: 935 EDRGQQLQAERKKMA---------QQMLDLEEQLEEEEAARQKLQL--EKVTAEAKIKKL 983
Query: 150 GDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPH------LLSNFEDFLTR 203
EDE ++L ++ L +E + L L +EE L + E ++
Sbjct: 984 ----EDEILVMDDQNNKLSKERKLLEER-ISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1038
Query: 204 IISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARS 263
+ +L++ + + ELE LKRK+ + +++ QI K Q L K E QA
Sbjct: 1039 LEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQ-LAKKEEELQAAL 1096
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTS 323
L+ ++ K L+++ + LEG + L D +A K + ++L ELE
Sbjct: 1097 ARLDDEIAQKNNALKKI----RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1152
Query: 324 WELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDER 383
EL+D + Q+ L ++E EV + ++L E Q+ +R+++ +E
Sbjct: 1153 TELEDTLDSTATQQE----LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208
Query: 384 DICFQKNKAAKANTAASRASWKKRSGSVIGK 414
++ K AKAN ++ + +K + + G+
Sbjct: 1209 TEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Score = 55.5 bits (132), Expect = 1e-07
Identities = 86/401 (21%), Positives = 165/401 (41%), Gaps = 56/401 (13%)
Query: 34 DSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFI----ARKDMQRLHKELPLSLEEL 89
++LE KE E+T+ L + ++ + D GK +++ ++ +E+ LEEL
Sbjct: 1494 EALEAKEELERTNKMLKA--EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 90 EDVFDAL-DADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDED 148
ED A DA + Q F +++ ++E + Q HE + L
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL------ 1605
Query: 149 LGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQL------KKEEPHLLSNFEDFLT 202
EDE Q + A+K LE D+K L LQ ++E L + +
Sbjct: 1606 -----EDERKQRALAA---AAKKKLE--GDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 203 RIISQLQEAHEEKNELECALK---RKIAAYDEEIQHLYEEM------EQQIKSEKEQF-- 251
+L++A ++E+ K +K + + ++ L E++ +Q EKE+
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1715
Query: 252 -----------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
L + R +AR +LE++L ++ +E ++ + ++ Q L ++
Sbjct: 1716 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1775
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
++ K + Q+L R+ + +L + + ++S + + K ++ E R
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 361 EKAGLLKQL----DFLRERNKHLRDERDICFQ-KNKAAKAN 396
EK K L L+E + DER + Q K +A K N
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1876
Score = 50.1 bits (118), Expect = 4e-06
Identities = 52/273 (19%), Positives = 121/273 (44%), Gaps = 22/273 (8%)
Query: 131 QVAQRHEE-KVYLSRGDEDLGDMGE------DEEAQFRMLMDRLGAQKVLEDESDVKQLW 183
Q+A++ EE + L+R D+++ + E L + L +++ ++++ ++
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR- 1142
Query: 184 LQLKKEEPHLLSNFEDFLTRIISQLQ---EAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
L +E L + ED L +Q + + +E L+ AL + +++ ++Q + ++
Sbjct: 1143 -DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 241 EQQIKSEKEQF---------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQC 291
Q ++ EQ L K+ + + + +L +L Q +++ K+K+LE Q
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1261
Query: 292 TALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEV 351
L + + +L +L E+E + L +A+ + L ++ L + + +
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ-DT 1320
Query: 352 YRVTESLQREKAGLLKQLDFLRERNKHLRDERD 384
+ + R+K + +L L E L+D+ D
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1353
Score = 45.4 bits (106), Expect = 1e-04
Identities = 89/409 (21%), Positives = 164/409 (40%), Gaps = 53/409 (12%)
Query: 63 DAEGKGFIARKDMQRLHKELPLSLEEL-EDVFDALDADGNGYLTPQEFTTGFSHFFFSQN 121
+AEGK KD+ L +L + E L E+ L+ +E + Q+
Sbjct: 1298 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS-------LQD 1350
Query: 122 NPSQEDAGEQVAQRHEE--KVYLSRGDEDLGDMGEDEEA------QFRMLMDRLGAQKVL 173
+E +Q +RH + LS + L D EA +F+ ++ L Q
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY-- 1408
Query: 174 EDESDVKQLWLQLKKEEPHLLSNFEDFLT------RIISQLQEAHEEKNELECALKRKIA 227
+ + +L+K + L +D + +++S L++ + ++L K +
Sbjct: 1409 ---EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
Y +E E E + K K L + E +ELE+ + E+E L + +
Sbjct: 1466 KYADERDRA--EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK 347
L K + + ++K +EL EL+ T +DA+ +LE + +A K E+
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQAT----EDAKLRLE-VNMQALKGQFER 1578
Query: 348 EMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKR 407
+++ E + ++ L +Q L E L DER K +A A A+ KK
Sbjct: 1579 DLQAR--DEQNEEKRRQLQRQ---LHEYETELEDER-----KQRALAA------AAKKKL 1622
Query: 408 SGSVIGKYVDSRGILRRWPQRDRGIPTLQYQT---QRDLEDCKHEMKKI 453
G + + + ++ + + + LQ Q QR+LED + +I
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Score = 44.7 bits (104), Expect = 2e-04
Identities = 39/178 (21%), Positives = 85/178 (47%), Gaps = 6/178 (3%)
Query: 171 KVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHE---EKNELECALKRKIA 227
KV + +++V+ + L + E + +D + + SQLQ+ E E+ + + K+
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKD-VASLSSQLQDTQELLQEETRQKLNVSTKLR 1339
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
+EE L +++++++ E +Q L + + + ++KL +E L + +KR
Sbjct: 1340 QLEEERNSLQDQLDEEM--EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQ 345
+ + L E A KL+ T L +EL+ +L + +Q + +L+++ K Q
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Score = 43.1 bits (100), Expect = 5e-04
Identities = 42/158 (26%), Positives = 74/158 (46%), Gaps = 10/158 (6%)
Query: 243 QIKSEKEQFLLKDTE--RFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
Q+ ++E+ K+ E + + R Q+ E +L EQ+ QLT+++ L+ Q A E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
+ +L QEL L L++ + + + LQ E K+ Q ++ + E L+
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ----QMLDLEEQLEE 961
Query: 361 EKAGLLK-QLDFLRERNKHLRDERDICF---QKNKAAK 394
E+A K QL+ + K + E +I Q NK +K
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 999
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 71.6 bits (174), Expect = 1e-12
Identities = 83/379 (21%), Positives = 169/379 (44%), Gaps = 37/379 (9%)
Query: 36 LEQKETQEQTSGQLV-MLRKAQEFFQTCDAEGKGFIARKDM----QRLHKELPLSLEELE 90
L+ KE Q + G+L M RK Q+ + + + A ++ + + L +ELE
Sbjct: 862 LKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELE 921
Query: 91 DVFDALDA-----DGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHE--EKVYLS 143
++ L++ + + E +H + +E+ Q Q + + +
Sbjct: 922 EILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIK 981
Query: 144 RGDEDLGDMGEDEEAQF----RMLMDRLG--AQKVLEDESDVKQLWLQLKKEEPHLLSNF 197
+ +E++ + ED+ ++F +++ DR+ + ++ E+E K L +++ ++ ++S+
Sbjct: 982 KMEEEILLL-EDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL-AKIRNKQEVMISDL 1039
Query: 198 EDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTE 257
E+ +L++ + + ELE A KRK+ ++Q E++ QI K Q L K E
Sbjct: 1040 EE-------RLKKEEKTRQELEKA-KRKLDGETTDLQDQIAELQAQIDELKLQ-LAKKEE 1090
Query: 258 RFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELAR 317
Q + + L K L+ + + L+ Q L D KA K + ++L+
Sbjct: 1091 ELQGALARGDDETLHKNNALKVV----RELQAQIAELQEDFESEKASRNKAEKQKRDLSE 1146
Query: 318 ELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNK 377
ELE EL+D + Q+ L ++E EV + ++L+ E Q+ +R+R+
Sbjct: 1147 ELEALKTELEDTLDTTAAQQE----LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHA 1202
Query: 378 HLRDERDICFQKNKAAKAN 396
+E ++ K KAN
Sbjct: 1203 TALEELSEQLEQAKRFKAN 1221
Score = 53.9 bits (128), Expect = 3e-07
Identities = 77/338 (22%), Positives = 144/338 (42%), Gaps = 43/338 (12%)
Query: 63 DAEGKGFIARKDMQRLHKELPLSLEEL-EDVFDALDADGNGYLTPQEFTTGFSHFFFSQN 121
+AE KG KD L +L + E L E+ L+ +E +N
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE-----------KN 1346
Query: 122 NPSQEDAGEQVAQRHEEKVYLS----------RGDEDLGDMGEDEEAQFRMLMDRLGAQK 171
+ ++ E+ A+++ EK L+ + D+DLG + EEA+ ++L D +
Sbjct: 1347 SLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQ 1406
Query: 172 VLEDESDVKQLWLQLKKEEPHLLSNFEDFLT------RIISQLQEAHEEKNELECALKRK 225
LE+++ + +L+K + L +D ++ S L++ ++ ++L K
Sbjct: 1407 RLEEKA---LAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI 1463
Query: 226 IAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQK 285
A Y EE E E + K K L + E +E E++ ++E L +
Sbjct: 1464 SARYAEERDRA--EAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521
Query: 286 RLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQ 345
+ L K + + +++ +EL EL+ T +DA+ +LE + +A K
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT----EDAKLRLE-VNMQAMKAQF 1576
Query: 346 EKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDER 383
E++++ E + +K L+KQ +RE L DER
Sbjct: 1577 ERDLQTR--DEQNEEKKRLLIKQ---VRELEAELEDER 1609
Score = 47.8 bits (112), Expect = 2e-05
Identities = 84/388 (21%), Positives = 152/388 (39%), Gaps = 46/388 (11%)
Query: 37 EQKETQEQTSGQLVMLRKAQ----EFFQTCDAEGKGFIAR-KDMQRLH----KELPLSLE 87
E ++T + T+ Q + K + E + + E K A+ +DM++ H +EL LE
Sbjct: 1154 ELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLE 1213
Query: 88 ELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDE 147
+ + L+ + G T + S+ + AQ E +S GD
Sbjct: 1214 QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDR 1273
Query: 148 DLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQ 207
++ E L + L L +E++ K + + K+ L S +D
Sbjct: 1274 LRVELAEKASK----LQNELDNVSTLLEEAEKKGI--KFAKDAASLESQLQD-------- 1319
Query: 208 LQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELE 267
QE +E+ + L +I +EE L E+ E++ ++ K L K Q++ + +
Sbjct: 1320 TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN--LEKQVLALQSQLADTK 1377
Query: 268 QKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQ 327
+K+ +E L + +K+L AL E KL+ T L +EL+ + +L
Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLD 1437
Query: 328 DAQQQLESLQQEACK----LHQEKEMEVYRVTE----------------SLQREKAGLLK 367
+Q +L+++ K L +EK + E SL R L+
Sbjct: 1438 HQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALE 1497
Query: 368 QLDFLRERNKHLR-DERDICFQKNKAAK 394
+ +NK LR D D+ K+ K
Sbjct: 1498 AKEEFERQNKQLRADMEDLMSSKDDVGK 1525
Score = 47.0 bits (110), Expect = 4e-05
Identities = 87/405 (21%), Positives = 168/405 (41%), Gaps = 64/405 (15%)
Query: 34 DSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFI----ARKDMQRLHKELPLSLEEL 89
++LE KE E+ + QL ++ + D GK +++ +++ +E+ LEEL
Sbjct: 1494 EALEAKEEFERQNKQL--RADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551
Query: 90 EDVFDAL-DADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDED 148
ED A DA + Q F + D + Q E+K L + +
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQF-----------ERDLQTRDEQNEEKKRLLIKQVRE 1600
Query: 149 LGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLK----------KEEPHLLSNFE 198
L EDE Q + + ++K +E D+K L Q++ K+ L + +
Sbjct: 1601 LEAELEDERKQRALAV---ASKKKME--IDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 199 DFLTRIISQLQEAHEEKNELECALK---RKIAAYDEEIQHLYEEM------EQQIKSEKE 249
D+ +L+EA ++E+ K +K+ + + EI L EE+ + + E++
Sbjct: 1656 DYQR----ELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD 1711
Query: 250 QF-------------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHH 296
+ LL + R +AR +LE++L ++ +E L + ++ Q L+
Sbjct: 1712 ELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNA 1771
Query: 297 DKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTE 356
+ ++ K Q+L R+ + +LQ+ + ++S + + K ++ E
Sbjct: 1772 ELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE 1831
Query: 357 SLQREKAGLLKQL----DFLRERNKHLRDERDICFQ-KNKAAKAN 396
+E+A K + L+E + DER Q K + KAN
Sbjct: 1832 QEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKAN 1876
Score = 35.4 bits (80), Expect = 0.11
Identities = 34/137 (24%), Positives = 59/137 (43%), Gaps = 13/137 (9%)
Query: 267 EQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKL----TNQELARELERT 322
E++L K++EL ++ +KQ ++EG+ + KH+ E + EL E E
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMER-KHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 323 SWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDE 382
L +Q+LE + + +E+E + LQ EK + + L E+ DE
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEER----NQILQNEKKKMQAHIQDLEEQ----LDE 961
Query: 383 RDICFQKNKAAKANTAA 399
+ QK + K A
Sbjct: 962 EEGARQKLQLEKVTAEA 978
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 69.3 bits (168), Expect = 7e-12
Identities = 80/341 (23%), Positives = 147/341 (43%), Gaps = 46/341 (13%)
Query: 126 EDAGEQVAQRHEEKVY-----LSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
+DAG + ++E V R ++ D E E+ R L RLG + +ES +
Sbjct: 1365 DDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEES--Q 1422
Query: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
+ QLKK+ L + +D + Q HE L++K +D E+ +EE
Sbjct: 1423 RALQQLKKKCQRLTAELQDTKLHLEGQQVRNHE--------LEKKQRRFDSELSQAHEEA 1474
Query: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
+++ K ++E+ L ++ + A + L+Q+L K+ ++ TQK LE + + + +
Sbjct: 1475 QRE-KLQREK-LQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1532
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
+A K+K ++L +++ EL + ++ L+Q KL E EME R T S +
Sbjct: 1533 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQ--AKLRLEMEMERMRQTHSKEM 1590
Query: 361 EKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKRSGSVIGKYVDSRG 420
E R++ + + R C +K K + +Y D +
Sbjct: 1591 E------------SRDEEVEEARQSCQKKLKQMEVQLEE--------------EYEDKQK 1624
Query: 421 ILRRWPQRDRGIPTLQYQ-TQRDLEDCKHEMKKICKAEVTL 460
+LR + + + TL Q +RD E K K + + + L
Sbjct: 1625 VLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALL 1665
Score = 46.6 bits (109), Expect = 5e-05
Identities = 58/238 (24%), Positives = 106/238 (44%), Gaps = 35/238 (14%)
Query: 117 FFSQNNPSQEDAGEQVAQRHE---EKVYLSRGDEDLGDMGEDEEAQFRMLMDRLG-AQKV 172
F S+ + + E+A + QR + EK L L E+++ MD G QKV
Sbjct: 1463 FDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKD------MDIAGFTQKV 1516
Query: 173 LEDESDVKQLWLQLKKEEPHLLS---NFEDFLTRIISQLQEAHEEKNELECALKRKIAAY 229
+ E++++ + Q K+E L D ++ Q +E E+ ++ + K+
Sbjct: 1517 VSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKL--- 1573
Query: 230 DEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQ-------LTQ 282
L EME+ ++ ++ +D E +AR Q ++KL E +LE+ + +
Sbjct: 1574 -----RLEMEMERMRQTHSKEMESRDEEVEEAR-QSCQKKLKQMEVQLEEEYEDKQKVLR 1627
Query: 283 KQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEA 340
+++ LEG+ L + E+ K L ++L+RT L DAQ L+ L+ A
Sbjct: 1628 EKRELEGKLATLSDQVNRRDFESEK------RLRKDLKRTKALLADAQLMLDHLKNSA 1679
Score = 45.1 bits (105), Expect = 1e-04
Identities = 42/198 (21%), Positives = 89/198 (44%), Gaps = 21/198 (10%)
Query: 156 EEAQFRMLMDRLGAQKVLE-DESDVKQLWLQLKKEEPHLLSNFEDF--LTRIISQLQEAH 212
EE R+ ++ Q LE D+ D+ +L +KK + + D + + +QL+EA+
Sbjct: 1731 EEQLSRLQREKNEIQNRLEEDQEDMNEL---MKKHKAAVAQASRDLAQINDLQAQLEEAN 1787
Query: 213 EEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTE-----------RFQA 261
+EK EL+ K+ A +++ L + M + +++ +++ E R ++
Sbjct: 1788 KEKQELQ----EKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLES 1843
Query: 262 RSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELER 321
+ L++ + +E +Q + R + Q L +TK E +L E +R+
Sbjct: 1844 LASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHE 1903
Query: 322 TSWELQDAQQQLESLQQE 339
+L+ + +SLQ +
Sbjct: 1904 LEMDLESLEAANQSLQAD 1921
Score = 43.9 bits (102), Expect = 3e-04
Identities = 66/266 (24%), Positives = 117/266 (43%), Gaps = 34/266 (12%)
Query: 163 LMDRLGAQKVLEDESDVKQLWLQ---LKKE-EPHLLSNFEDFLTRIISQLQEAHEEKNEL 218
L+D A++ L E ++K+L Q LKK+ E + E L R E ++
Sbjct: 1311 LLDAETAER-LRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGG 1369
Query: 219 ECALK--RKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQE 276
E LK R + D + L +E E +++ E Q ++LE++L + +
Sbjct: 1370 EWRLKYERAVREVDFTKKRLQQEFEDKLEVE------------QQNKRQLERRLGDLQAD 1417
Query: 277 LEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQ--QLE 334
E+ + ++L+ +C L + +TK ++ N EL ++ R EL A + Q E
Sbjct: 1418 SEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQRE 1477
Query: 335 SLQQEACKLHQEKEM---EVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNK 391
LQ+E KL +EK+M E + + + L+ K +D K + E ++ Q
Sbjct: 1478 KLQRE--KLQREKDMLLAEAFSLKQQLEE------KDMDIAGFTQKVVSLEAEL--QDIS 1527
Query: 392 AAKANTAASRASWKKRSGSVIGKYVD 417
+ ++ AS A KK+ + K D
Sbjct: 1528 SQESKDEASLAKVKKQLRDLEAKVKD 1553
Score = 36.2 bits (82), Expect = 0.064
Identities = 76/379 (20%), Positives = 148/379 (39%), Gaps = 49/379 (12%)
Query: 37 EQKETQEQTSGQLVM---LRKAQEFFQTCDAEGKGFIARKDMQR--LHKELPLSLEE--- 88
E ++T+ GQ V L K Q F + ++ R+ +QR L +E + L E
Sbjct: 1438 ELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFS 1497
Query: 89 LEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDED 148
L+ + D D G+ SQ + + + Q + + + +E+
Sbjct: 1498 LKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEE 1557
Query: 149 LGD------MGEDEEAQFRMLMDRLGAQKVLEDESDVKQL-------WLQLKKEEPHLLS 195
L + M E + + M M+R+ E ES +++ +LK+ E L
Sbjct: 1558 LDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEE 1617
Query: 196 NFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKD 255
+ED Q+ EK ELE K+A +++ E E++++ + LK
Sbjct: 1618 EYED--------KQKVLREKRELE----GKLATLSDQVNRRDFESEKRLRKD-----LKR 1660
Query: 256 TERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL 315
T+ A +Q + L ++ Q + +LE + T A K + + +
Sbjct: 1661 TKALLADAQLMLDHLKNSAPSKREIAQLKNQLE--------ESEFTCAAAVKAR---KAM 1709
Query: 316 ARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRER 375
E+E ++ D + +L+++ +L +EK R+ E + + K + +
Sbjct: 1710 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQA 1769
Query: 376 NKHLRDERDICFQKNKAAK 394
++ L D+ Q +A K
Sbjct: 1770 SRDLAQINDLQAQLEEANK 1788
Score = 33.5 bits (75), Expect = 0.42
Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 12/151 (7%)
Query: 243 QIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHD-KHET 301
+++ +EQ KD E Q+L KL E+E +L RLE + + L + E
Sbjct: 1248 EVQLSEEQIRNKDEE-----IQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDER 1302
Query: 302 KAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQRE 361
+ +L + E A L R E+++ Q Q ++L+++ + EMEV E
Sbjct: 1303 NTGESASQLLDAETAERL-RAEKEMKELQTQYDALKKQM----EVMEMEVMEARLIRAAE 1357
Query: 362 KAGLLKQLDFLRE-RNKHLRDERDICFQKNK 391
G + D E R K+ R R++ F K +
Sbjct: 1358 INGEVDDDDAGGEWRLKYERAVREVDFTKKR 1388
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 69.3 bits (168), Expect = 7e-12
Identities = 80/341 (23%), Positives = 147/341 (43%), Gaps = 46/341 (13%)
Query: 126 EDAGEQVAQRHEEKVY-----LSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
+DAG + ++E V R ++ D E E+ R L RLG + +ES +
Sbjct: 1365 DDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEES--Q 1422
Query: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
+ QLKK+ L + +D + Q HE L++K +D E+ +EE
Sbjct: 1423 RALQQLKKKCQRLTAELQDTKLHLEGQQVRNHE--------LEKKQRRFDSELSQAHEEA 1474
Query: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
+++ K ++E+ L ++ + A + L+Q+L K+ ++ TQK LE + + + +
Sbjct: 1475 QRE-KLQREK-LQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1532
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
+A K+K ++L +++ EL + ++ L+Q KL E EME R T S +
Sbjct: 1533 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQ--AKLRLEMEMERMRQTHSKEM 1590
Query: 361 EKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKRSGSVIGKYVDSRG 420
E R++ + + R C +K K + +Y D +
Sbjct: 1591 E------------SRDEEVEEARQSCQKKLKQMEVQLEE--------------EYEDKQK 1624
Query: 421 ILRRWPQRDRGIPTLQYQ-TQRDLEDCKHEMKKICKAEVTL 460
+LR + + + TL Q +RD E K K + + + L
Sbjct: 1625 VLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALL 1665
Score = 46.6 bits (109), Expect = 5e-05
Identities = 58/238 (24%), Positives = 106/238 (44%), Gaps = 35/238 (14%)
Query: 117 FFSQNNPSQEDAGEQVAQRHE---EKVYLSRGDEDLGDMGEDEEAQFRMLMDRLG-AQKV 172
F S+ + + E+A + QR + EK L L E+++ MD G QKV
Sbjct: 1463 FDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKD------MDIAGFTQKV 1516
Query: 173 LEDESDVKQLWLQLKKEEPHLLS---NFEDFLTRIISQLQEAHEEKNELECALKRKIAAY 229
+ E++++ + Q K+E L D ++ Q +E E+ ++ + K+
Sbjct: 1517 VSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKL--- 1573
Query: 230 DEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQ-------LTQ 282
L EME+ ++ ++ +D E +AR Q ++KL E +LE+ + +
Sbjct: 1574 -----RLEMEMERMRQTHSKEMESRDEEVEEAR-QSCQKKLKQMEVQLEEEYEDKQKVLR 1627
Query: 283 KQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEA 340
+++ LEG+ L + E+ K L ++L+RT L DAQ L+ L+ A
Sbjct: 1628 EKRELEGKLATLSDQVNRRDFESEK------RLRKDLKRTKALLADAQLMLDHLKNSA 1679
Score = 45.1 bits (105), Expect = 1e-04
Identities = 42/198 (21%), Positives = 89/198 (44%), Gaps = 21/198 (10%)
Query: 156 EEAQFRMLMDRLGAQKVLE-DESDVKQLWLQLKKEEPHLLSNFEDF--LTRIISQLQEAH 212
EE R+ ++ Q LE D+ D+ +L +KK + + D + + +QL+EA+
Sbjct: 1731 EEQLSRLQREKNEIQNRLEEDQEDMNEL---MKKHKAAVAQASRDLAQINDLQAQLEEAN 1787
Query: 213 EEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTE-----------RFQA 261
+EK EL+ K+ A +++ L + M + +++ +++ E R ++
Sbjct: 1788 KEKQELQ----EKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLES 1843
Query: 262 RSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELER 321
+ L++ + +E +Q + R + Q L +TK E +L E +R+
Sbjct: 1844 LASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHE 1903
Query: 322 TSWELQDAQQQLESLQQE 339
+L+ + +SLQ +
Sbjct: 1904 LEMDLESLEAANQSLQAD 1921
Score = 43.9 bits (102), Expect = 3e-04
Identities = 66/266 (24%), Positives = 117/266 (43%), Gaps = 34/266 (12%)
Query: 163 LMDRLGAQKVLEDESDVKQLWLQ---LKKE-EPHLLSNFEDFLTRIISQLQEAHEEKNEL 218
L+D A++ L E ++K+L Q LKK+ E + E L R E ++
Sbjct: 1311 LLDAETAER-LRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGG 1369
Query: 219 ECALK--RKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQE 276
E LK R + D + L +E E +++ E Q ++LE++L + +
Sbjct: 1370 EWRLKYERAVREVDFTKKRLQQEFEDKLEVE------------QQNKRQLERRLGDLQAD 1417
Query: 277 LEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQ--QLE 334
E+ + ++L+ +C L + +TK ++ N EL ++ R EL A + Q E
Sbjct: 1418 SEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQRE 1477
Query: 335 SLQQEACKLHQEKEM---EVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNK 391
LQ+E KL +EK+M E + + + L+ K +D K + E ++ Q
Sbjct: 1478 KLQRE--KLQREKDMLLAEAFSLKQQLEE------KDMDIAGFTQKVVSLEAEL--QDIS 1527
Query: 392 AAKANTAASRASWKKRSGSVIGKYVD 417
+ ++ AS A KK+ + K D
Sbjct: 1528 SQESKDEASLAKVKKQLRDLEAKVKD 1553
Score = 36.2 bits (82), Expect = 0.064
Identities = 76/379 (20%), Positives = 148/379 (39%), Gaps = 49/379 (12%)
Query: 37 EQKETQEQTSGQLVM---LRKAQEFFQTCDAEGKGFIARKDMQR--LHKELPLSLEE--- 88
E ++T+ GQ V L K Q F + ++ R+ +QR L +E + L E
Sbjct: 1438 ELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFS 1497
Query: 89 LEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDED 148
L+ + D D G+ SQ + + + Q + + + +E+
Sbjct: 1498 LKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEE 1557
Query: 149 LGD------MGEDEEAQFRMLMDRLGAQKVLEDESDVKQL-------WLQLKKEEPHLLS 195
L + M E + + M M+R+ E ES +++ +LK+ E L
Sbjct: 1558 LDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEE 1617
Query: 196 NFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKD 255
+ED Q+ EK ELE K+A +++ E E++++ + LK
Sbjct: 1618 EYED--------KQKVLREKRELE----GKLATLSDQVNRRDFESEKRLRKD-----LKR 1660
Query: 256 TERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL 315
T+ A +Q + L ++ Q + +LE + T A K + + +
Sbjct: 1661 TKALLADAQLMLDHLKNSAPSKREIAQLKNQLE--------ESEFTCAAAVKAR---KAM 1709
Query: 316 ARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRER 375
E+E ++ D + +L+++ +L +EK R+ E + + K + +
Sbjct: 1710 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQA 1769
Query: 376 NKHLRDERDICFQKNKAAK 394
++ L D+ Q +A K
Sbjct: 1770 SRDLAQINDLQAQLEEANK 1788
Score = 33.5 bits (75), Expect = 0.42
Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 12/151 (7%)
Query: 243 QIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHD-KHET 301
+++ +EQ KD E Q+L KL E+E +L RLE + + L + E
Sbjct: 1248 EVQLSEEQIRNKDEE-----IQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDER 1302
Query: 302 KAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQRE 361
+ +L + E A L R E+++ Q Q ++L+++ + EMEV E
Sbjct: 1303 NTGESASQLLDAETAERL-RAEKEMKELQTQYDALKKQM----EVMEMEVMEARLIRAAE 1357
Query: 362 KAGLLKQLDFLRE-RNKHLRDERDICFQKNK 391
G + D E R K+ R R++ F K +
Sbjct: 1358 INGEVDDDDAGGEWRLKYERAVREVDFTKKR 1388
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 68.6 bits (166), Expect = 1e-11
Identities = 76/386 (19%), Positives = 177/386 (45%), Gaps = 29/386 (7%)
Query: 34 DSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVF 93
+ L++K + Q +LV K++ D + K + R + ++L + + L
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRK--LERAQLLLPQQQLQVEADRLGKEL 271
Query: 94 DALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMG 153
++ A + E + + +E EQ + E+++ + +E +
Sbjct: 272 QSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQE 331
Query: 154 E---DEEAQFRMLMDRLGAQ--KVLEDESDVKQ----LWLQLKK--EEPHLLSNFEDFLT 202
E ++E + R D++ Q K+ E E +++ +W Q +K E+ + E+ +
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMW 391
Query: 203 RIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE-QFLLKDTERFQA 261
R +++E E++ E ++K+ DE+I+ EEM +Q + +E + +++D E
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEE--- 448
Query: 262 RSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELER 321
+ +E+E+K+ ++E E++ +++++++ Q E K + + K QE + E
Sbjct: 449 KLREVEEKM---QEEEEKMQEQEEKIQRQ---------EEKIQEQEEKTWRQEKLLKQEE 496
Query: 322 TSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRD 381
WE ++ + E E + QE+E ++ R E ++ ++ L +Q + ++E+ L++
Sbjct: 497 KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQE 556
Query: 382 ERDICFQKNKAAKANTAASRASWKKR 407
+ + + A+ A R S +R
Sbjct: 557 LEERLGKLGQKAELLGGAGRESGSQR 582
Score = 40.4 bits (93), Expect = 0.003
Identities = 44/211 (20%), Positives = 95/211 (45%), Gaps = 8/211 (3%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
QE+ ++ R E+K + DE + E EE +R +++++D+ + +
Sbjct: 400 QEEKRQEKMWRQEKK--MREQDEKIR---EQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454
Query: 185 QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQI 244
+ +EE + E+ + R ++QE E+ E LK++ +++E + +E +
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWE 514
Query: 245 KSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKH---ET 301
+ EK Q + +R + + +E E +L +E+++++ + + LE + L
Sbjct: 515 QEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGA 574
Query: 302 KAENTKLKLTNQELARELERTSWELQDAQQQ 332
E+ +L ++E S E Q QQQ
Sbjct: 575 GRESGSQRLPTLTPILQVELKSQEAQSLQQQ 605
Score = 36.2 bits (82), Expect = 0.064
Identities = 54/242 (22%), Positives = 99/242 (40%), Gaps = 35/242 (14%)
Query: 173 LEDESDVKQLWLQLKKE----------EPHLLSNFEDFLTRIISQLQEAHEEKNELECAL 222
LE+ D KQ LK+ E +S+ + + S ++ E+ NE
Sbjct: 90 LEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNEKNYTF 149
Query: 223 KRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQ------ARSQELEQKLLCKEQE 276
++++ ++ L E Q+ E LL++T F ++L ++ E
Sbjct: 150 RKRVVIKKPWLR-LGEVTAQK---RPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLE 205
Query: 277 LEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLES- 335
L + T + L+ + L ++E ++++L ++L R+LER L Q Q+E+
Sbjct: 206 LYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEAD 265
Query: 336 -----LQQEACKLH-QEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQK 389
LQ + KL Q +E E++ + Q EK R+ K E +C Q+
Sbjct: 266 RLGKELQSVSAKLQAQVEENELWNLLNQQQEEK--------MWRQEEKIQEQEEKMCEQE 317
Query: 390 NK 391
K
Sbjct: 318 LK 319
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 68.6 bits (166), Expect = 1e-11
Identities = 76/386 (19%), Positives = 177/386 (45%), Gaps = 29/386 (7%)
Query: 34 DSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVF 93
+ L++K + Q +LV K++ D + K + R + ++L + + L
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRK--LERAQLLLPQQQLQVEADRLGKEL 271
Query: 94 DALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMG 153
++ A + E + + +E EQ + E+++ + +E +
Sbjct: 272 QSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQE 331
Query: 154 E---DEEAQFRMLMDRLGAQ--KVLEDESDVKQ----LWLQLKK--EEPHLLSNFEDFLT 202
E ++E + R D++ Q K+ E E +++ +W Q +K E+ + E+ +
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMW 391
Query: 203 RIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE-QFLLKDTERFQA 261
R +++E E++ E ++K+ DE+I+ EEM +Q + +E + +++D E
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEE--- 448
Query: 262 RSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELER 321
+ +E+E+K+ ++E E++ +++++++ Q E K + + K QE + E
Sbjct: 449 KLREVEEKM---QEEEEKMQEQEEKIQRQ---------EEKIQEQEEKTWRQEKLLKQEE 496
Query: 322 TSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRD 381
WE ++ + E E + QE+E ++ R E ++ ++ L +Q + ++E+ L++
Sbjct: 497 KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQE 556
Query: 382 ERDICFQKNKAAKANTAASRASWKKR 407
+ + + A+ A R S +R
Sbjct: 557 LEERLGKLGQKAELLGGAGRESGSQR 582
Score = 40.4 bits (93), Expect = 0.003
Identities = 44/211 (20%), Positives = 95/211 (45%), Gaps = 8/211 (3%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
QE+ ++ R E+K + DE + E EE +R +++++D+ + +
Sbjct: 400 QEEKRQEKMWRQEKK--MREQDEKIR---EQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454
Query: 185 QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQI 244
+ +EE + E+ + R ++QE E+ E LK++ +++E + +E +
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWE 514
Query: 245 KSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKH---ET 301
+ EK Q + +R + + +E E +L +E+++++ + + LE + L
Sbjct: 515 QEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGA 574
Query: 302 KAENTKLKLTNQELARELERTSWELQDAQQQ 332
E+ +L ++E S E Q QQQ
Sbjct: 575 GRESGSQRLPTLTPILQVELKSQEAQSLQQQ 605
Score = 35.8 bits (81), Expect = 0.084
Identities = 37/148 (25%), Positives = 66/148 (44%), Gaps = 26/148 (17%)
Query: 251 FLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKL 310
++ K T+ A S EL + + E+ E+ + Q++L ++E ++++L
Sbjct: 191 YIEKLTKERDALSLELYRNTITDEELKEKNAELQEKLR-----------LVESEKSEIQL 239
Query: 311 TNQELARELERTSWELQDAQQQLES------LQQEACKLH-QEKEMEVYRVTESLQREKA 363
++L R+LER L Q Q+E+ LQ + KL Q +E E++ + Q EK
Sbjct: 240 NVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEK- 298
Query: 364 GLLKQLDFLRERNKHLRDERDICFQKNK 391
R+ K E +C Q+ K
Sbjct: 299 -------MWRQEEKIQEQEEKMCEQELK 319
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 68.6 bits (166), Expect = 1e-11
Identities = 83/359 (23%), Positives = 162/359 (45%), Gaps = 31/359 (8%)
Query: 33 LDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLH-KELPLSLEELED 91
+ ++E+ +E+ S Q + R QE + IA+ +Q+LH KEL +EL
Sbjct: 441 IKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAK--LQKLHEKELARKEQELTK 498
Query: 92 VFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGD 151
+ + + + + SQ QE + + ++K L+ + L D
Sbjct: 499 KLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL-QKKAILTESENKLRD 557
Query: 152 MGEDEEA-QFRMLMDRLGAQKVL-EDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQ 209
+ ++ E + R+L +K L E+++ K L + L+ E+ + ++ +
Sbjct: 558 LQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN---KHNKEITVMVEKHKT 614
Query: 210 EAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTER-FQARSQELEQ 268
E K++ + K+ ++ Q E++ ++ + EKE LLKD E FQA +E+ +
Sbjct: 615 ELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKET-LLKDKEIIFQAHIEEMNE 673
Query: 269 KLLCKEQELEQLTQKQKRLEGQCTALHH---DKHETKAENTKLKLTNQELARELERTSWE 325
K LE+L KQ LE + L +H+ + E + LK ++ +ELE
Sbjct: 674 K------TLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE----- 722
Query: 326 LQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLD-FLRERNKHLRDER 383
+Q QQ+ + +E E+ + R ++L+ + + QL+ L+ER+KHL++ +
Sbjct: 723 -AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ----INQLELLLKERDKHLKEHQ 776
Score = 58.2 bits (139), Expect = 2e-08
Identities = 75/381 (19%), Positives = 167/381 (43%), Gaps = 56/381 (14%)
Query: 30 LHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEEL 89
L L+ ++ E+T + LR A+ + + + KG + + +++H+ L + EE+
Sbjct: 327 LQELEKIKDLHMAEKTK-LITQLRDAKNLIEQLEQD-KGMVIAETKRQMHETLEMKEEEI 384
Query: 90 EDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHE--EKVYLSRGDE 147
+ + ++ TT GE++ ++ E E+ ++
Sbjct: 385 AQLRSRI----------KQMTT----------------QGEELREQKEKSERAAFEELEK 418
Query: 148 DLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQ--LKKEEPHLLSNFEDFLTRII 205
L + EEA+ ++ + K +E S+ +++ LQ L + + ++ + I
Sbjct: 419 ALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQI 478
Query: 206 SQLQEAHE-EKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQ 264
++LQ+ HE E E L +K+ + E Q E+M+ ++ + ++L E+ Q S
Sbjct: 479 AKLQKLHEKELARKEQELTKKLQTREREFQ---EQMKVALEKSQSEYLKISQEKEQQESL 535
Query: 265 ELEQKLLCKEQELEQLTQKQKRLEGQCT---------------ALHHDKHETKAENTKLK 309
LE+ L K+ L + K + L+ + +L +K+++K L+
Sbjct: 536 ALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLE 595
Query: 310 LT----NQELARELERTSWELQDAQQQLESLQQEACK-LHQEKEMEVYRVTESLQREKAG 364
N+E+ +E+ EL+ + Q ++L E + L Q+ + E+ ++ E ++EK
Sbjct: 596 AEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKET 655
Query: 365 LLKQLDFLRERNKHLRDERDI 385
LLK + + + + +E+ +
Sbjct: 656 LLKDKEIIFQAHIEEMNEKTL 676
Score = 56.6 bits (135), Expect = 5e-08
Identities = 57/231 (24%), Positives = 110/231 (47%), Gaps = 30/231 (12%)
Query: 187 KKEEPHLLSNFEDFLTRIISQLQEAHE----EKNELECALKRKIAAYDEEIQHLYEEMEQ 242
++E ++S +E L + +LQE HE EK + LK+KI + E EEM +
Sbjct: 1037 RRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCE----KEEMNK 1092
Query: 243 QIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETK 302
+I KE+ + +DT EL+++L K + L Q + +L+ L D +++
Sbjct: 1093 EITWLKEEGVKQDTTL-----NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147
Query: 303 AENT-------KLKLTNQELARELERTSWELQDAQQQLESLQ---QEACKLHQEKEMEVY 352
ENT +LK+ +E R++ + +L+ ++ +SL+ +++ K ++K +E
Sbjct: 1148 KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFK 1207
Query: 353 RVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRAS 403
+++E L QLD ++ + L + + ++K N SR S
Sbjct: 1208 KLSEE-------LAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRIS 1251
Score = 55.8 bits (133), Expect = 8e-08
Identities = 53/227 (23%), Positives = 112/227 (49%), Gaps = 20/227 (8%)
Query: 170 QKVLEDESD----VKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRK 225
QK+L+ E++ KQ+ +++ ++ + + + ++ +Q+ ++ +E+E +K
Sbjct: 826 QKLLDLETERILLTKQV-AEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSL 884
Query: 226 IAAYDEEIQHLYEEMEQ--QIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQK 283
Y+ +++ +E EQ QI EKE +L+ E + + L QKL KE + L ++
Sbjct: 885 TQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEE 944
Query: 284 -QKRLEGQCTALHHDKHETK--AENTKLKLTNQE--LARELERTSWELQDAQQQLESLQQ 338
+ + + Q + K + K E K KL +QE L +ELE T+ EL ++Q +
Sbjct: 945 YETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA--- 1001
Query: 339 EACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDI 385
K+ + + +++++ R + +Q++ L E H R+ D+
Sbjct: 1002 ---KMLEMAQANSAGISDAVSRLETNQKEQIESLTE--VHRRELNDV 1043
Score = 49.3 bits (116), Expect = 7e-06
Identities = 54/184 (29%), Positives = 83/184 (45%), Gaps = 27/184 (14%)
Query: 190 EPHLLSNFEDFLTRIISQLQEAHEEKNEL---------ECALKRKIAAYDEEI--QHLYE 238
+P LLSN E + +L A EK +L + + RK + EI + +
Sbjct: 1914 QPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQ 1973
Query: 239 EMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQK--QKRLEGQCTALHH 296
E E++IK E+E LK + +E +L KEQELE ++ K E + L
Sbjct: 1974 EREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLES 2033
Query: 297 DKHETKAENTKLKLTNQEL------------ARELERTSWELQDAQQQLESLQQE-ACKL 343
+ ET K+ + +L ARE E T+ +++D Q QLE LQ++ KL
Sbjct: 2034 HQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA-KVRDLQTQLEELQKKYQQKL 2092
Query: 344 HQEK 347
QE+
Sbjct: 2093 EQEE 2096
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/259 (22%), Positives = 118/259 (45%), Gaps = 30/259 (11%)
Query: 170 QKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAY 229
+K L+D+ + QL L LK+ + HL + +AH E LE +KR
Sbjct: 751 EKALKDQ--INQLELLLKERDKHLKEH-------------QAHVEN--LEADIKRS---- 789
Query: 230 DEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEG 289
+ E+Q +++ + + + T+ ++ + +L+QKLL E E LT++ +E
Sbjct: 790 EGELQQASAKLD--VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEA 847
Query: 290 Q----CTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQ 345
Q CT L K + + +L+ N E+ ++++ + + + Q++ ++
Sbjct: 848 QKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILV 907
Query: 346 EKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWK 405
EKE + ++ E Q+++ +L Q +E + H+ +E KN+ K +A K
Sbjct: 908 EKENMILQMREG-QKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA--K 964
Query: 406 KRSGSVIGKYVDSRGILRR 424
+ ++ K +D L++
Sbjct: 965 EMQETLKKKLLDQEAKLKK 983
Score = 47.4 bits (111), Expect = 3e-05
Identities = 78/393 (19%), Positives = 167/393 (42%), Gaps = 62/393 (15%)
Query: 17 QGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQ 76
+ G+ G + L++L+Q+ +++ +L++ +E Q+ + + K+
Sbjct: 265 ESDGEPVVEDGTSVKTLETLQQRVKRQEN-----LLKRCKETIQSHKEQCTLLTSEKEA- 318
Query: 77 RLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRH 136
L ++L L+ELE + D A+ +T ++D G +A+
Sbjct: 319 -LQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQL-------EQDKGMVIAETK 370
Query: 137 EEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSN 196
+ + +M E+E AQ R + ++ Q ++L Q +K E +
Sbjct: 371 RQM-------HETLEMKEEEIAQLRSRIKQMTTQG--------EELREQKEKSER---AA 412
Query: 197 FEDFLTRIISQLQEAHEEKNELECALKRKIAAYD-----------EEIQHLYEEMEQQIK 245
FE+ L + +S Q+ E + +L+ + +I + +E+ + +E+ +K
Sbjct: 413 FEE-LEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMK 471
Query: 246 SEKEQFLLK----DTERFQARSQELEQKLLCKEQEL-EQLTQKQKRLEGQCTALHHDKHE 300
E+ + K + + QEL +KL +E+E EQ+ ++ + + + +K +
Sbjct: 472 KSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQ 531
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
++ L L EL ++ L +++ +L LQQEA + ++ + +E+ E +
Sbjct: 532 QES----LALEELELQKKA-----ILTESENKLRDLQQEA-ETYRTRILELESSLEKSLQ 581
Query: 361 EKAGLLKQL--DFLRERNKHLRDERDICFQKNK 391
E K L E+NKH E + +K+K
Sbjct: 582 ENKNQSKDLAVHLEAEKNKH-NKEITVMVEKHK 613
Score = 47.4 bits (111), Expect = 3e-05
Identities = 74/322 (22%), Positives = 126/322 (39%), Gaps = 53/322 (16%)
Query: 155 DEEAQFRMLMDRLGAQKV--LEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQ--- 209
D+ +D L +K+ LE D + + KK+ + ++ + + QL+
Sbjct: 1412 DQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471
Query: 210 -EAHEEKNELECALKRKIAAYDEEIQHLYEEMEQ-QIKSEKEQFLLKDTERFQ-ARSQEL 266
EA+E+ ++ LK ++ ++ L EME + K EK++ L+ + Q AR EL
Sbjct: 1472 KEAYEKDEQINL-LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMEL 1530
Query: 267 EQKLLCKEQELEQLTQKQKRLEGQCTALH----------------HDKHETKAENTKLKL 310
E + K E+E L + K Q H D +AE L L
Sbjct: 1531 EDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTL 1590
Query: 311 TNQ--ELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQRE------- 361
NQ + ELE EL+ ++S ++E L E E L+R+
Sbjct: 1591 ENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAA 1650
Query: 362 -KAGLLKQLDFLRERNK-----HLRD--------ERDICFQKNKAAKANTAASRASWKKR 407
K LL Q++ E+ K HL + ER++ + K ++ S R
Sbjct: 1651 IKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPR 1710
Query: 408 SGSVIGKY-----VDSRGILRR 424
S + Y DS+G +++
Sbjct: 1711 SAKNVAAYTEQEEADSQGCVQK 1732
Score = 46.6 bits (109), Expect = 5e-05
Identities = 44/176 (25%), Positives = 82/176 (46%), Gaps = 16/176 (9%)
Query: 201 LTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE--QFLLKDTER 258
++ + +QL++ EE+N L + ++ H EE E QIKS K + L+ + E
Sbjct: 1271 VSELEAQLRQLTEEQNTLNISF--------QQATHQLEEKENQIKSMKADIESLVTEKEA 1322
Query: 259 FQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARE 318
Q +Q KE + QL ++ T + + E K E + L +L +
Sbjct: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
Query: 319 LERTSWELQDAQQQLESLQ----QEACKLHQEKEMEVYRVTESLQREKAGLLKQLD 370
L+ S L + + + SL+ +E C+L + + ++V ++L +EK L+Q+D
Sbjct: 1383 LQ-NSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKV-DTLSKEKISALEQVD 1436
Score = 42.4 bits (98), Expect = 9e-04
Identities = 63/273 (23%), Positives = 118/273 (43%), Gaps = 28/273 (10%)
Query: 122 NPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQ 181
N ++ +Q H+E V + ++LG+ ++ + +K+L E+ V
Sbjct: 1545 NEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKE--------AEEKILTLENQVYS 1596
Query: 182 LWLQL---KKEEPHL---LSNFEDFLTRIISQLQ-EAHEEKNELECALKRKIAAYDEEIQ 234
+ +L KKE H+ + + E+ L + +L+ E+ + EL+ ++KIAA +++
Sbjct: 1597 MKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLL 1656
Query: 235 HLYEEMEQQIKSEKEQFLLKDTERFQARSQE---LEQKLLCKEQELEQLTQKQKRLEGQC 291
EE E+Q K E L + + Q R +E LE+KL K E Q +
Sbjct: 1657 SQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKL--KSVESSQSETLIVPRSAKN 1714
Query: 292 TALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEV 351
A + ++ E ++ K T +E L+R E + Q++ ++E H E +
Sbjct: 1715 VAAYTEQEEADSQGCVQK-TYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY 1773
Query: 352 ------YRVTESLQREKAGLLKQL-DFLRERNK 377
E+ Q E ++ L + L E+NK
Sbjct: 1774 QERLIKLEHAEAKQHEDQSMIGHLQEELEEKNK 1806
Score = 41.6 bits (96), Expect = 0.002
Identities = 61/270 (22%), Positives = 115/270 (42%), Gaps = 42/270 (15%)
Query: 133 AQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLM----------DRLGAQKVLEDESDVKQL 182
A++HE++ + E+L E++ ++ +++ + + A++ LE+ D Q
Sbjct: 1785 AKQHEDQSMIGHLQEEL----EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQK 1840
Query: 183 WLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDE------EIQHL 236
LQ K+ +L L + + +E H + E + K+ A + + L
Sbjct: 1841 TLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELL 1900
Query: 237 YEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHH 296
E E++ KS Q L +A+ +LE KL E+E ++L ++ RL+ L
Sbjct: 1901 EENTEEKSKSHLVQPKL--LSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRK 1958
Query: 297 D----------------KHETKAENTKLKLTNQELARELERT-SWELQDAQQQLESLQQE 339
+ + + K E L+L + ++L R + +L +Q+LE +E
Sbjct: 1959 EHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKE 2018
Query: 340 ACKLHQEKEMEVYRVTESLQREKAGLLKQL 369
QE E E + ES Q E LLK++
Sbjct: 2019 TINKAQEVEAE---LLESHQEETNQLLKKI 2045
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 68.2 bits (165), Expect = 2e-11
Identities = 106/442 (23%), Positives = 198/442 (44%), Gaps = 55/442 (12%)
Query: 42 QEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGN 101
QEQ + +L++ +E Q + E + R++ +R ++E E+L+ + L +
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKR---RRQEQERQYREE----EQLQQEEEQLLREER 948
Query: 102 GYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFR 161
QE + Q Q E +R +E+ R +E+L + EE Q
Sbjct: 949 EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL----QQEEEQ-- 1002
Query: 162 MLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECA 221
+L + ++ E E ++ +L++EE LL E+ R + + + + E+ EL+
Sbjct: 1003 LLREEREKRRRQEWERQYRKKD-ELQQEEEQLLR--EEREKRRLQERERQYREEEELQQE 1059
Query: 222 LKRKIAAYDE-----EIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKE-- 274
++ + E E++ Y + E++++ E+EQ L ++ E+ R QE E++ C+E
Sbjct: 1060 EEQLLGEERETRRRQELERQYRK-EEELQQEEEQLLREEPEK--RRRQERERQ--CREEE 1114
Query: 275 ---QELEQLT--QKQKRLEGQCTALHHDKHETKAENTKLKLTNQELAR--ELERTSWELQ 327
QE EQL +++KR + + ++ E + E +L E R ELER E +
Sbjct: 1115 ELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE 1174
Query: 328 DAQQQLESL-QQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLR---------ERNK 377
+ QQ+ E L ++E K QE+E + YR E LQR+K + + R E+
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERERQ-YREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233
Query: 378 HLRDERDIC-------FQKNKAAKANTAASRASWKKRSGSVIGKYVDSRGILRRWPQRDR 430
+RD + C F++ + ++ S+ + G + D RRW QRDR
Sbjct: 1234 AVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER--DREQERRRWQQRDR 1291
Query: 431 GIPTLQYQTQRDLEDCKHEMKK 452
P + + + ++ K +K
Sbjct: 1292 HFPEEEQLEREEQKEAKRRDRK 1313
Score = 67.8 bits (164), Expect = 2e-11
Identities = 67/273 (24%), Positives = 126/273 (46%), Gaps = 26/273 (9%)
Query: 130 EQVAQRHEEK-------VYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQL 182
EQ +RHE+K L R E+ D + EE R +R Q + E + ++
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 183 WLQLKKEEPH-LLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEME 241
WL+L++EE E L R + +E ++ E E L++++ + + + E E
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547
Query: 242 QQIKSEKEQFLLKDT-------------ERFQARSQELEQKLLCKEQELEQLTQKQKRLE 288
Q +K E+E+ L ++ ++ R +E Q+ L +EQE E+L Q+ KR E
Sbjct: 548 QLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE-ERLEQRLKREE 606
Query: 289 GQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKE 348
+ ++ E + + K + +E ++L ++ + + QQQL QQE + ++E
Sbjct: 607 VE----RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662
Query: 349 MEVYRVTESLQREKAGLLKQLDFLRERNKHLRD 381
E R+ + L+RE ++ + E + R+
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARE 695
Score = 62.0 bits (149), Expect = 1e-09
Identities = 74/292 (25%), Positives = 137/292 (46%), Gaps = 42/292 (14%)
Query: 123 PSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQK--VLEDES--- 177
P +E+ ++ QR E +++L + E+E+ Q R +L ++ + ED+
Sbjct: 812 PEEEEKEQRRRQRRER-------EKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR 864
Query: 178 ------DVKQLWL--QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAY 229
D K W + +K H L ++ + Q EE+ EL+ + K
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924
Query: 230 DEEIQH-----LYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQ 284
++E Q+ L +E EQ ++ E+E+ ++ ER + ++L+QK +EQ L + +K+
Sbjct: 925 EQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK---EEQLLGEEPEKR 981
Query: 285 KRLEGQCTALHHDKHETKAENTKLKLTNQELARELE-----RTSWELQDAQQQLESLQQE 339
+R E + + ++ E + E +L +E R E R ELQ ++QL ++E
Sbjct: 982 RRQERE--KKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039
Query: 340 ACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNK 391
+L QE+E + YR E LQ+E+ LL + ER R E + ++K +
Sbjct: 1040 KRRL-QERERQ-YREEEELQQEEEQLLGE-----ERETRRRQELERQYRKEE 1084
Score = 58.9 bits (141), Expect = 9e-09
Identities = 79/304 (25%), Positives = 132/304 (43%), Gaps = 54/304 (17%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
QE+ EQ +R EE+ L + + ++E + L+ R +K LE E ++L
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR-EEEKRLEQERREQRLKR 569
Query: 185 QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEE--MEQ 242
+ ++ LL E+ R +L+ EE+ LE LKR EE++ L +E EQ
Sbjct: 570 EQEERRDQLLKREEE---RRQQRLKREQEER--LEQRLKR------EEVERLEQEERREQ 618
Query: 243 QIK-----SEKEQFLLKDTERFQARSQELE-------QKLLCKEQELEQLTQKQKRLEGQ 290
++K E+ Q LLK E+ + R Q+L ++ L +E+E E+L Q+ KR
Sbjct: 619 RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR---- 674
Query: 291 CTALHHDKHETKAENTKLKLTNQELARE-----LERTSWELQ---DAQQQ---LESLQQE 339
+HE + +L QE ARE + + W+L+ DA+Q +QE
Sbjct: 675 -------EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727
Query: 340 ACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAA 399
+ QE+E + R LQ ++ + + + RD +Q K+
Sbjct: 728 GQRRRQEQEEKRRRRESELQWQEE------ERAHRQQQEEEQRRDFTWQWQAEEKSERGR 781
Query: 400 SRAS 403
R S
Sbjct: 782 QRLS 785
Score = 57.0 bits (136), Expect = 4e-08
Identities = 63/286 (22%), Positives = 129/286 (45%), Gaps = 15/286 (5%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFR---MLMDRLGAQKVLEDESDVKQ 181
Q++A + + EEK L R + + ++ + +FR L+ Q + E D K
Sbjct: 1304 QKEAKRRDRKSQEEKQLL-REEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKF 1362
Query: 182 LWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEME 241
+L+ +E E+ R + ++ +E+ +L C + + D + + + E E
Sbjct: 1363 REEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK--FREEE 1420
Query: 242 QQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHET 301
QQ+ ++ ++ E+ Q R QE E+K L +EQ+L Q ++ R E Q ++
Sbjct: 1421 QQLSRQERDRKFREEEQ-QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479
Query: 302 KAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQRE 361
+ E + L ++ R ER + + +Q+L S + E L +E+++ + +E
Sbjct: 1480 RQERDRKFLEEEQQLRRQER---DRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQE 1536
Query: 362 KAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKR 407
+ L +Q ER + R +RD F++ + + + S ++R
Sbjct: 1537 EQQLRRQ-----ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER 1577
Score = 56.2 bits (134), Expect = 6e-08
Identities = 66/273 (24%), Positives = 125/273 (45%), Gaps = 18/273 (6%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDE--EAQFRMLMDRLGAQKVLEDES 177
+ QE+ EQ +R +E+ R ++ L E+E E Q R + ++ L E
Sbjct: 326 ERREQQEERREQQLRREQEE----RREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381
Query: 178 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLY 237
+++ QL++E+ ++ + Q E++ E L+R+ E +H
Sbjct: 382 QLRREQ-QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ 440
Query: 238 EEMEQQIKSEKEQFL--LKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALH 295
E EQ++K E+E+ LK E + QE ++ L ++QE E+ ++ +LE +
Sbjct: 441 ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE-EERRERWLKLEEEERREQ 499
Query: 296 HDKHETKAENTKLKLTNQELAR--ELERTSWELQDAQQ---QLESLQQEACKLHQEKEME 350
++ E + + + Q L R E ER L+ QQ + E +++ K +EK +E
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLE 559
Query: 351 VYRVTESLQREKAGLLKQLDFLRERNKHLRDER 383
R + L+RE+ ++ D L +R + R +R
Sbjct: 560 QERREQRLKREQE---ERRDQLLKREEERRQQR 589
Score = 55.8 bits (133), Expect = 8e-08
Identities = 73/335 (21%), Positives = 139/335 (41%), Gaps = 43/335 (12%)
Query: 63 DAEGKGFIARKDMQRL-HKELPLSLEELED------VFDALDADGNGYLTPQEFTTGFSH 115
D +G + +KD++ L +E L D + + LD D NG + EF
Sbjct: 22 DCDGAA-LTKKDLKNLLEREFGAVLRRPHDPKTVDLILELLDLDSNGRVDFNEFLL---- 76
Query: 116 FFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLED 175
F F G+ E++ + L D ++E+ + DR LE+
Sbjct: 77 FIFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQ-----LEE 131
Query: 176 ESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH 235
E ++ + ++E +L E E+ + E +R DEE+
Sbjct: 132 EPGQRRRQKRQEQER----------------ELAEGEEQSEKQERLEQRDRQRRDEELWR 175
Query: 236 LYEEMEQQIKSEKEQFLLK-----DTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQ 290
+E +++ + E+ L+ +TE F Q ++LL ++ + Q+Q+R
Sbjct: 176 QRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQD 235
Query: 291 CTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQ-QEACKLHQEKEM 349
++ E + T L+ ++L E + ELQ+ ++QL L+ QE + QE+E
Sbjct: 236 RVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQ 295
Query: 350 EVYRVTESLQREKAGLLKQLDFLRERNKHLRDERD 384
+ R L+RE+ KQ + RE+ + R++++
Sbjct: 296 QQQR----LRREQQLRRKQEEERREQQEERREQQE 326
Score = 53.9 bits (128), Expect = 3e-07
Identities = 60/270 (22%), Positives = 123/270 (45%), Gaps = 19/270 (7%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
+E ++ Q EE++ E + E+E+ Q R+ + Q++ + + ++
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRRE----QQLRRKQEEERREQQ 318
Query: 185 QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQI 244
+ ++E+ E+ R QL+ EE+ E + +++ +++++ EE ++
Sbjct: 319 EERREQQERREQQEE---RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 245 KSEKEQFLLKDTERFQARSQELEQKL-----LCKEQEL---EQLTQKQKRLEGQCTALHH 296
+ +EQ L ++ + + + EQ+L L +EQ+L +QL ++Q+ Q H
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHE 435
Query: 297 DKHETKAENTKLKLTNQE----LARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVY 352
KHE + +LK +E L RE E E + +QQL+ Q+E + K E
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE 495
Query: 353 RVTESLQREKAGLLKQLDFLRERNKHLRDE 382
R + +RE+ +Q + +R K +E
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEE 525
Score = 53.5 bits (127), Expect = 4e-07
Identities = 90/393 (22%), Positives = 170/393 (43%), Gaps = 61/393 (15%)
Query: 37 EQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDAL 96
E++ QE+ QL + ++F E + + R++ R +E L +E E F L
Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFL-----EEEQQLRRQERDRKFREQELRSQEPERKF--L 1518
Query: 97 DADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQ------RHEEKVYLSRGDEDLG 150
+ + + ++ F + +++ G+Q Q R EE++ R ++ L
Sbjct: 1519 EEEQQLHRQQRQ-----RKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573
Query: 151 DMGEDEEAQFRMLMDRLGAQ----KVLEDESDVKQL--WLQLKKEEPHLLSNFEDFLTRI 204
++ + +FR+ ++ Q K +EDE +++ QL++E E L
Sbjct: 1574 R--QERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER 1631
Query: 205 ISQL---QEAHEEKNELECALKR----------KIAAYDEEIQHLYEEMEQQIKSEKEQF 251
Q QE + E E L+R + + EE Q L E EQQ++ ++
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691
Query: 252 LLKDTERFQARSQELEQKLLCKEQEL--EQLTQK-----QKRLEGQCTALHH-------- 296
++ E+ Q R QE E+K L +EQ+L ++L +K Q R E + L
Sbjct: 1692 KFREEEQ-QLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKIL 1750
Query: 297 DKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTE 356
++ + + E + +L QE R+ Q+ ++Q Q+ K +E+++ R +
Sbjct: 1751 EEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQ 1810
Query: 357 SLQ-REKAGLLK----QLDFLRERNKHLRDERD 384
L+ +++ G + QL L E+ + LR ERD
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQ-LEEQEQRLRQERD 1842
Score = 51.2 bits (121), Expect = 2e-06
Identities = 69/314 (21%), Positives = 136/314 (43%), Gaps = 57/314 (18%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
+E+ E++ QR + + R +++L + E E+A+ R+ Q LE E+D +Q +
Sbjct: 661 REEEEERLEQRLKREHEEERREQELAEE-EQEQARERIKSRIPKWQWQLESEADARQSKV 719
Query: 185 QL---KKEEPHLLSNFEDFLTRIISQLQ-----EAHEEKNELECALKRKIAAYDEEIQHL 236
K+E E+ R S+LQ AH ++ E E +R+ + + +
Sbjct: 720 YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE---QRRDFTWQWQAEEK 776
Query: 237 YEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHH 296
E Q++ + ++ + Q+ EQ+ L +E+E EQ ++++ E + L
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 297 DKHETKAENTKL-------------KLTNQELARELERTSWELQD--------------- 328
++ + E + + +QE R+ ++ W+L++
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD-QKWRWQLEEERKRRRHTLYAKPAL 895
Query: 329 ----------AQQQLESLQQEACKLHQEKEME-VYRVTESLQREKAGLLKQLDFLRERNK 377
Q++ E LQ+E + + +E E YR E LQ+E+ LL++ ER K
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE-----EREK 950
Query: 378 HLRDERDICFQKNK 391
R ER+ ++K+K
Sbjct: 951 RRRQERERQYRKDK 964
Score = 47.8 bits (112), Expect = 2e-05
Identities = 73/351 (20%), Positives = 150/351 (42%), Gaps = 51/351 (14%)
Query: 117 FFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDE 176
F ++ +E+ G++ Q+ +E+ + +L + E E Q R+ ++ Q+ E+
Sbjct: 122 FEPRDRQLEEEPGQRRRQKRQEQ------ERELAEGEEQSEKQERL--EQRDRQRRDEEL 173
Query: 177 SDVKQLWL----------QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKI 226
+Q W QL+ + H F D +L E + E + +R
Sbjct: 174 WRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRR-- 231
Query: 227 AAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKR 286
E +++E E++ ++E L K+ E+ Q + +++L +E++L +L +++ R
Sbjct: 232 ----ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287
Query: 287 LEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDA---QQQLESLQQEACKL 343
E Q E + + +L+ Q+L R+ E E Q+ QQ+ Q+E +
Sbjct: 288 RERQ---------EEEQQQQRLR-REQQLRRKQEEERREQQEERREQQERREQQEERREQ 337
Query: 344 HQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDE---RDICFQKNKAAKANTAAS 400
+E E R + L+RE+ ++ RE+ + R++ R+ ++ + +
Sbjct: 338 QLRREQEERR-EQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR 396
Query: 401 RASWKKRSGSVIGKYVDSRGILRRWPQRDRGIPTLQYQTQRDLEDCKHEMK 451
R +R + + LRR Q R + Q +R+ E+ +HE K
Sbjct: 397 REQQLRRE-----QQLRREQQLRREQQLRR-----EQQLRREQEEERHEQK 437
Score = 47.8 bits (112), Expect = 2e-05
Identities = 65/296 (21%), Positives = 126/296 (42%), Gaps = 16/296 (5%)
Query: 154 EDEEAQFRMLMDRLGAQKV-LEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAH 212
E+EE ++R L ++ L++E +Q LQ ++E+ L E R Q +E
Sbjct: 240 EEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE---LRRERQEEEQQ 296
Query: 213 EEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLC 272
+++ E L+RK +EE + EE +Q + +EQ + ++ + +E ++ L
Sbjct: 297 QQRLRREQQLRRK---QEEERREQQEERREQ-QERREQQEERREQQLRREQEERREQQLR 352
Query: 273 KEQELE------QLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWEL 326
+EQE E + Q+++R E Q + E + + Q+L RE + +
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Query: 327 QDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDIC 386
+QQL QQ + +E+ + + QR K ++ D+L+ + R E++
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE-- 470
Query: 387 FQKNKAAKANTAASRASWKKRSGSVIGKYVDSRGILRRWPQRDRGIPTLQYQTQRD 442
+K + + R W K + + R R Q +R L+ Q + +
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEE 526
Score = 47.4 bits (111), Expect = 3e-05
Identities = 58/255 (22%), Positives = 113/255 (44%), Gaps = 33/255 (12%)
Query: 130 EQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKE 189
E+ Q ++ R +E L GE+++ + R DR K E+E ++ ++E
Sbjct: 1656 EREQQLRHDRDRKFREEEQLLQEGEEQQLR-RQERDR----KFREEEQQLR------RQE 1704
Query: 190 EPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE 249
E L R +L+ E+ +L +++ E + + EE +Q++ E+E
Sbjct: 1705 RERKFLQEEQQLRR--QELERKFREEEQLRQETEQEQLRRQERYRKILEE--EQLRPERE 1760
Query: 250 QFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLK 309
+ Q R QE ++K +E EQL +Q+R E Q + D+ + E + +
Sbjct: 1761 E--------QQLRRQERDRKF----REEEQL--RQEREEQQLRSQESDRKFREEEQLRQE 1806
Query: 310 LTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQL 369
Q+L + + ++ Q QLE +Q +L QE++ + YR E ++ ++
Sbjct: 1807 REEQQLRPQQRDGKYRWEEEQLQLEEQEQ---RLRQERDRQ-YRAEEQFATQEKSRREEQ 1862
Query: 370 DFLRERNKHLRDERD 384
+ +E + R ER+
Sbjct: 1863 ELWQEEEQKRRQERE 1877
Score = 46.6 bits (109), Expect = 5e-05
Identities = 66/248 (26%), Positives = 116/248 (46%), Gaps = 26/248 (10%)
Query: 130 EQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLK-K 188
EQ+ Q EE+ L R + D E+E+ R +R K L++E +++ L+ K +
Sbjct: 1673 EQLLQEGEEQ-QLRRQERDR-KFREEEQQLRRQERER----KFLQEEQQLRRQELERKFR 1726
Query: 189 EEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEK 248
EE L E QL+ + LE + ++ EE Q +E +++ + E+
Sbjct: 1727 EEEQLRQETEQ------EQLRRQERYRKILE---EEQLRPEREEQQLRRQERDRKFREEE 1777
Query: 249 EQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHD-KHETKAENTK 307
+ L ++ E Q RSQE ++K +E EQL +Q+R E Q D K+ + E +
Sbjct: 1778 Q--LRQEREEQQLRSQESDRKF----REEEQL--RQEREEQQLRPQQRDGKYRWEEEQLQ 1829
Query: 308 LKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLK 367
L+ Q L +E +R + ++ E ++E +L QE+E + + E RE+ +
Sbjct: 1830 LEEQEQRLRQERDR-QYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ 1888
Query: 368 QLDFLRER 375
Q + R R
Sbjct: 1889 QKEEQRHR 1896
Score = 39.7 bits (91), Expect = 0.006
Identities = 67/305 (21%), Positives = 126/305 (41%), Gaps = 48/305 (15%)
Query: 130 EQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKE 189
E +R +E+ R +E+L E + R R ++ +E +V+Q QL +E
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156
Query: 190 EPHLLSNFEDFLTRIISQLQEAHEEKNEL-----ECALKRKIAAYDEEIQHLYEEMEQQI 244
EP E L R + +E +E+ +L E + + Y EE + ++ +Q+
Sbjct: 1157 EPEKRRRQE--LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214
Query: 245 KSE-----------------------------KEQFL-LKDTERFQARSQELEQKLLCKE 274
+ E EQF L+D++ +SQ+ Q LL ++
Sbjct: 1215 RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274
Query: 275 QELEQLTQKQKRLEGQCTALHHDKHE----TKAENTKLKLTNQELARELERTSWELQDAQ 330
QE + ++Q+R Q H + E + + K + + ++L R E + +
Sbjct: 1275 QERD---REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331
Query: 331 QQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLD----FLRERNKHLRDERDIC 386
Q+ + +E +L QE+E + R E ++ + L+ + FL E + R ER+
Sbjct: 1332 QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERK 1391
Query: 387 FQKNK 391
F K +
Sbjct: 1392 FLKEE 1396
Score = 30.8 bits (68), Expect = 2.7
Identities = 34/144 (23%), Positives = 65/144 (45%), Gaps = 27/144 (18%)
Query: 135 RHEEKVYLSRGDEDLGDMGED----EEAQFRMLMDRLGAQKVLEDESDVKQLW----LQL 186
R EE++ R ++ L D EE Q R + Q++ + D K W LQL
Sbjct: 1774 REEEQLRQEREEQQLRSQESDRKFREEEQLRQEREE---QQLRPQQRDGKYRWEEEQLQL 1830
Query: 187 KKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKS 246
+++E L + + ++ Q A +EK+ E Q L++E EQ+ +
Sbjct: 1831 EEQEQRLRQERD---RQYRAEEQFATQEKSR-------------REEQELWQEEEQKRRQ 1874
Query: 247 EKEQFLLKDTERFQARSQELEQKL 270
E+E+ L ++ R Q + ++ +++
Sbjct: 1875 ERERKLREEHIRRQQKEEQRHRQV 1898
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 67.0 bits (162), Expect = 3e-11
Identities = 88/383 (22%), Positives = 169/383 (44%), Gaps = 56/383 (14%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLM----------DRLGAQKV-- 172
++ A E + EE V L++ E + D+ + R L+ D+L ++ V
Sbjct: 113 EQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKL 172
Query: 173 ---LEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKR----- 224
L ++ +Q + K+E H +S F+ + + ++ +K +LE LK+
Sbjct: 173 RESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADM 232
Query: 225 -----KIAAYDEEIQHLYEEM---EQQIKSEK--EQFLLKDTERFQARSQELEQKLLCKE 274
+I A + +Q EE+ EQQ+K +K + K+ E+FQ R+ +L+Q+
Sbjct: 233 DSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHS 292
Query: 275 QELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLE 334
EQL+Q+ ++ + A + H+ + + KL +++ ++L T + + +Q E
Sbjct: 293 LVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKE 352
Query: 335 SLQQEACKLHQEKEMEVYRVTESLQREKAG-LLKQLDFLRERNKHLRDERDICFQKNKAA 393
+L+ + L E+E+E + L R+ LL++ D L NK++ + ++
Sbjct: 353 TLKNQIVGL--EREVEASKKQAELDRKAMDELLRERDIL---NKNMLKAVNATQKQTDLV 407
Query: 394 KANTAASRASWKKRSGSVIGKYVDS-----RGILRRWPQRDRGIPTLQYQTQR---DLED 445
K + A K+ I Y D + I +RDR I TQ+ ++ED
Sbjct: 408 KLHEQA-----KRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMED 462
Query: 446 CK-------HEMKKICKAEVTLE 461
K KKI ++E+ L+
Sbjct: 463 IKVRETQIFDYRKKIAESEIKLK 485
Score = 43.1 bits (100), Expect = 5e-04
Identities = 66/315 (20%), Positives = 132/315 (41%), Gaps = 32/315 (10%)
Query: 137 EEKVYLSRGDEDLGDMGEDEEAQFRMLMDR--LGAQKVLEDESDVKQLWLQLKKEEPHLL 194
E +V S+ +L DE + R ++++ L A + ++D+ +L Q K+ +
Sbjct: 362 EREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEI 421
Query: 195 SNFEDFLTR---IISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM--------EQQ 243
N++D + II L++ + L +K+ E+I+ ++ E +
Sbjct: 422 QNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESE 481
Query: 244 IKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKA 303
IK +++Q L E ++ + L+ + E+ + +K K + Q L D ++
Sbjct: 482 IKLKQQQNLY---EAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKES 538
Query: 304 ENTKLKLTNQELARELERTSWELQDAQQQ-LESLQQEACKLHQEKEMEVYRVTESLQREK 362
KL L Q + +E E ELQ +QQ LE+ + + + +E ++ R+ E+
Sbjct: 539 ALVKLHLEQQRIEKEKETLKAELQKLRQQALET--KHFIEKQEAEERKLLRIIAEADGER 596
Query: 363 AGLLKQL-------DFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKRSGSV---- 411
K+L D L + DE + ++K K ++ + + +R +
Sbjct: 597 LRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILR 656
Query: 412 --IGKYVDSRGILRR 424
I K +GIL R
Sbjct: 657 LEIKKLRREKGILAR 671
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 62.4 bits (150), Expect = 8e-10
Identities = 97/373 (26%), Positives = 160/373 (42%), Gaps = 51/373 (13%)
Query: 54 KAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGF 113
K ++ F + D G + + + + L +L +++ D D +G LT +EF
Sbjct: 224 KYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAM 283
Query: 114 SHFFFSQNN-PSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKV 172
+ + P + +V G + D+ RL + V
Sbjct: 284 HLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQ---------RLPEEPV 334
Query: 173 LEDESDVKQLWLQL----KKEEPHLLSNFEDFLTR--IISQLQEAHEEKNELECA-LKRK 225
LEDE + L + KK E N E R ++ Q ++ E +LE A +RK
Sbjct: 335 LEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERK 394
Query: 226 IAAYDEEIQHLYEEMEQQIKSEKE------QFLLKDTERFQARSQELE------------ 267
E+ + E+E+Q++ ++E + K+ ER +A +ELE
Sbjct: 395 ERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRR 454
Query: 268 QKLLC---KEQE-LEQLTQKQKRLEGQCTALHHDKH--ETKAENTKLKLTNQELARELER 321
Q+LL KEQE + L K+K LE + AL+ KH E K ++ + +LT Q E
Sbjct: 455 QELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTN 514
Query: 322 TSWELQDA-----QQQLESLQQEACKLHQEKEM---EVYRVTE-SLQREKAGLLKQ-LDF 371
S EL+ A QQQL+ QQ +L EK++ ++ +V + SL R+ LK+ L+
Sbjct: 515 KSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEA 574
Query: 372 LRERNKHLRDERD 384
+HLRD+ D
Sbjct: 575 KELARQHLRDQLD 587
Score = 35.0 bits (79), Expect = 0.14
Identities = 63/266 (23%), Positives = 111/266 (41%), Gaps = 48/266 (18%)
Query: 119 SQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESD 178
+Q N QED A++ + L E L D E + + + RL Q+ E ES
Sbjct: 459 NQRNKEQEDIVVLKAKKKTLEFEL----EALNDKKHQLEGKLQDIRCRLTTQRQ-EIEST 513
Query: 179 VKQLWLQLKKEEPHL---LSNFEDFLTRIISQLQEAHEEKNELE---------CALKRKI 226
K L++ E HL L + L R+I + Q +++ +++ LKR +
Sbjct: 514 NKSRELRIA-EITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRAL 572
Query: 227 AAYDEEIQHL---YEEMEQQIKSEKEQF-----LLKDTERFQARSQELEQK------LLC 272
A + QHL +E+E++ +S+ ++ LK+ + Q +QK L
Sbjct: 573 EAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQ 632
Query: 273 KEQELEQLTQKQKRLEGQCTALHHDK------------HETKAENTKLKLTNQELARELE 320
KEQE + + ++++ E Q A DK + + + KL +E ++ +
Sbjct: 633 KEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKD 692
Query: 321 RTSWELQDAQQQLESLQQEACKLHQE 346
Q+AQ +L L + HQE
Sbjct: 693 GEEKGKQEAQDKLGRLFHQ----HQE 714
Score = 33.9 bits (76), Expect = 0.32
Identities = 35/128 (27%), Positives = 58/128 (45%), Gaps = 12/128 (9%)
Query: 280 LTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQE 339
L +Q++LE + DK E L+L + A LE+ E Q+ QLE +QE
Sbjct: 335 LEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQAL-LEQQRKE-QERLAQLERAEQE 392
Query: 340 ACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAA 399
+E+E + E ++ + L KQL+ RE + +ER ++ +AAK
Sbjct: 393 ----RKERERQ-----EQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELER 443
Query: 400 SR-ASWKK 406
R W++
Sbjct: 444 QRQLEWER 451
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 62.4 bits (150), Expect = 8e-10
Identities = 97/373 (26%), Positives = 160/373 (42%), Gaps = 51/373 (13%)
Query: 54 KAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGF 113
K ++ F + D G + + + + L +L +++ D D +G LT +EF
Sbjct: 224 KYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAM 283
Query: 114 SHFFFSQNN-PSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKV 172
+ + P + +V G + D+ RL + V
Sbjct: 284 HLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQ---------RLPEEPV 334
Query: 173 LEDESDVKQLWLQL----KKEEPHLLSNFEDFLTR--IISQLQEAHEEKNELECA-LKRK 225
LEDE + L + KK E N E R ++ Q ++ E +LE A +RK
Sbjct: 335 LEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERK 394
Query: 226 IAAYDEEIQHLYEEMEQQIKSEKE------QFLLKDTERFQARSQELE------------ 267
E+ + E+E+Q++ ++E + K+ ER +A +ELE
Sbjct: 395 ERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRR 454
Query: 268 QKLLC---KEQE-LEQLTQKQKRLEGQCTALHHDKH--ETKAENTKLKLTNQELARELER 321
Q+LL KEQE + L K+K LE + AL+ KH E K ++ + +LT Q E
Sbjct: 455 QELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTN 514
Query: 322 TSWELQDA-----QQQLESLQQEACKLHQEKEM---EVYRVTE-SLQREKAGLLKQ-LDF 371
S EL+ A QQQL+ QQ +L EK++ ++ +V + SL R+ LK+ L+
Sbjct: 515 KSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEA 574
Query: 372 LRERNKHLRDERD 384
+HLRD+ D
Sbjct: 575 KELARQHLRDQLD 587
Score = 35.0 bits (79), Expect = 0.14
Identities = 63/266 (23%), Positives = 111/266 (41%), Gaps = 48/266 (18%)
Query: 119 SQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESD 178
+Q N QED A++ + L E L D E + + + RL Q+ E ES
Sbjct: 459 NQRNKEQEDIVVLKAKKKTLEFEL----EALNDKKHQLEGKLQDIRCRLTTQRQ-EIEST 513
Query: 179 VKQLWLQLKKEEPHL---LSNFEDFLTRIISQLQEAHEEKNELE---------CALKRKI 226
K L++ E HL L + L R+I + Q +++ +++ LKR +
Sbjct: 514 NKSRELRIA-EITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRAL 572
Query: 227 AAYDEEIQHL---YEEMEQQIKSEKEQF-----LLKDTERFQARSQELEQK------LLC 272
A + QHL +E+E++ +S+ ++ LK+ + Q +QK L
Sbjct: 573 EAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQ 632
Query: 273 KEQELEQLTQKQKRLEGQCTALHHDK------------HETKAENTKLKLTNQELARELE 320
KEQE + + ++++ E Q A DK + + + KL +E ++ +
Sbjct: 633 KEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKD 692
Query: 321 RTSWELQDAQQQLESLQQEACKLHQE 346
Q+AQ +L L + HQE
Sbjct: 693 GEEKGKQEAQDKLGRLFHQ----HQE 714
Score = 33.9 bits (76), Expect = 0.32
Identities = 35/128 (27%), Positives = 58/128 (45%), Gaps = 12/128 (9%)
Query: 280 LTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQE 339
L +Q++LE + DK E L+L + A LE+ E Q+ QLE +QE
Sbjct: 335 LEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQAL-LEQQRKE-QERLAQLERAEQE 392
Query: 340 ACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAA 399
+E+E + E ++ + L KQL+ RE + +ER ++ +AAK
Sbjct: 393 ----RKERERQ-----EQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELER 443
Query: 400 SR-ASWKK 406
R W++
Sbjct: 444 QRQLEWER 451
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 61.2 bits (147), Expect = 2e-09
Identities = 48/267 (17%), Positives = 136/267 (50%), Gaps = 25/267 (9%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQK--VLEDES 177
Q + GEQ Q E++ + + +E +G+ +E Q R +++G Q+ V + E
Sbjct: 193 QMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGE----QEEQMRKQEEQMGEQEEQVQKQEE 248
Query: 178 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLY 237
V++ Q++K+E Q++E E+ E E + ++ ++E Q
Sbjct: 249 QVQKQEEQMRKQE---------------EQMREQEEQMREQEEQMLKQKEQTEQEEQT-- 291
Query: 238 EEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHD 297
E E+Q++ ++EQ ++ + + Q EQ+ +QE EQ+ ++++++ Q +
Sbjct: 292 GEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQE-EQMWEQKEQMWEQKEQMWKQ 350
Query: 298 KHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTES 357
+ + + +++ +++ ++ E+ + + ++Q E ++++ ++ ++KE ++ E
Sbjct: 351 EEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKE-QMGEQKEQ 409
Query: 358 LQREKAGLLKQLDFLRERNKHLRDERD 384
++ ++ + +Q + +R++ +H+ ++++
Sbjct: 410 MREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 56.2 bits (134), Expect = 6e-08
Identities = 54/269 (20%), Positives = 129/269 (47%), Gaps = 19/269 (7%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQK--VLEDES 177
Q +E G+ Q + + + E G + E +E Q R ++G Q+ + E E
Sbjct: 148 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE-QEGQVREQEGQMGEQEGQMGEQEE 206
Query: 178 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLY 237
+ + Q++K+E + E+ + + Q+ E E+ + E ++ +E+++
Sbjct: 207 QMGEQEEQMQKQEEQM-GEQEEQMRKQEEQMGEQEEQVQKQE----EQVQKQEEQMRKQE 261
Query: 238 EEMEQQIKS--EKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALH 295
E+M +Q + E+E+ +LK E+ + Q EQ+ +EQE EQ+ ++++++
Sbjct: 262 EQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQE-EQMREQEEQM-------- 312
Query: 296 HDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVT 355
++ E E + +E E + WE ++ + E E + Q++E +V +
Sbjct: 313 REQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQE 372
Query: 356 ESLQREKAGLLKQLDFLRERNKHLRDERD 384
E +++++ + KQ + +R++ + + ++++
Sbjct: 373 EQMRKQEEQMRKQEEQMRKQEEQMGEQKE 401
Score = 46.2 bits (108), Expect = 6e-05
Identities = 49/274 (17%), Positives = 126/274 (45%), Gaps = 22/274 (8%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQK--VLEDES 177
Q +E G+ Q + + + E G + E +E Q R ++ Q+ V E E
Sbjct: 85 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE-QEGQVREQEGQVREQEGQVREQEG 143
Query: 178 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLY 237
V++ Q++++E + E + Q++E + E E ++ + E+ +
Sbjct: 144 QVREQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMG 202
Query: 238 EEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHD 297
E+ E+Q+ ++EQ ++ + + Q +Q+ EQE EQ+ +++++++ Q +
Sbjct: 203 EQ-EEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQE-EQVQKQEEQVQKQEEQMRKQ 260
Query: 298 KHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTES 357
+ + + + +++ +++ ++ E+T E Q +Q+ + +QE QE++M
Sbjct: 261 EEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMR------- 313
Query: 358 LQREKAGLLKQLDFLRERNKHLRDERDICFQKNK 391
+Q + +RE+ + + + + +++ +
Sbjct: 314 ---------EQEEQMREQEEQMGKQEEQMWEQKE 338
Score = 38.1 bits (87), Expect = 0.017
Identities = 43/248 (17%), Positives = 113/248 (45%), Gaps = 22/248 (8%)
Query: 157 EAQFRMLMDRLGAQKV-LEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEK 215
+ + L +L K+ L E V++ Q++++E + E + Q++E +
Sbjct: 31 QLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQV 89
Query: 216 NELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQ 275
E E ++ + E+ + E E Q++ ++ Q ++ + + Q EQ+ +EQ
Sbjct: 90 REQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 148
Query: 276 ELE-------------QLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERT 322
E + Q+ +++ ++ Q + + + + + ++ ++ + E+
Sbjct: 149 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQM 208
Query: 323 SWELQDAQQQLESL-QQEACKLHQEKEM-----EVYRVTESLQREKAGLLKQLDFLRERN 376
+ + Q+Q E + +QE QE++M +V + E +Q+++ + KQ + +RE+
Sbjct: 209 GEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQE 268
Query: 377 KHLRDERD 384
+ +R++ +
Sbjct: 269 EQMREQEE 276
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 61.2 bits (147), Expect = 2e-09
Identities = 64/261 (24%), Positives = 125/261 (47%), Gaps = 26/261 (9%)
Query: 151 DMGEDE----EAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIIS 206
D GED E Q L ++L K ++ K++ L+ E LL + R+
Sbjct: 432 DQGEDLRHGLETQVMELQNKL---KHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEE 488
Query: 207 QLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE--QFLLKDTERFQARSQ 264
QL+ E L+ ALK ++A+ D+E++H+ ++ ++ + + Q +D +A Q
Sbjct: 489 QLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQ 548
Query: 265 ELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELAREL----E 320
++ + ++ELE+ +++ + D TK E +L++ +E+ EL E
Sbjct: 549 KMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIE 608
Query: 321 RTSWELQDAQ------QQLESLQQEACKLHQE-KEMEVYRVTESL--QREKAGLLKQLDF 371
EL+ A+ +Q+E L++E + +E KE++ R ++ + + L KQL
Sbjct: 609 VLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAV 668
Query: 372 LR---ERNKHLRDERDICFQK 389
LR +R + L +E+++ QK
Sbjct: 669 LRVEADRGREL-EEQNLQLQK 688
Score = 50.4 bits (119), Expect = 3e-06
Identities = 81/375 (21%), Positives = 147/375 (39%), Gaps = 31/375 (8%)
Query: 37 EQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDAL 96
E +ET E+T M +K +E + E R + + + +EL +E L+ +
Sbjct: 560 ELEETSEETGHWQSMFQKNKEDLRATKQELLQL--RMEKEEMEEELGEKIEVLQRELEQA 617
Query: 97 DADGNG-----YLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGD 151
A L + T SQE AG + E+++ + R + D G
Sbjct: 618 RASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGR 677
Query: 152 MGEDEEAQFRMLMDRLG--------AQKVLEDESDVK-QLWLQLKKEEPHLLSNFEDFLT 202
E++ Q + + +L A+ V E E+ V Q ++ ++F
Sbjct: 678 ELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRR 737
Query: 203 RIISQLQEAHEEKN------ELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDT 256
RI+ Q+ E + +E L+ K+ + E Q L E + E+E L
Sbjct: 738 RILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNAS--QEEEGSLAAAK 795
Query: 257 ERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELA 316
+AR +E ++ L QE + L + + Q L K E + + L T L
Sbjct: 796 RALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLN 855
Query: 317 RELER----TSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLK---QL 369
+ELE+ + LQ Q QLE +++A + + + + ++ GL + ++
Sbjct: 856 KELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 915
Query: 370 DFLRERNKHLRDERD 384
LR+ + + ERD
Sbjct: 916 QRLRQALQASQAERD 930
Score = 39.3 bits (90), Expect = 0.008
Identities = 39/139 (28%), Positives = 71/139 (51%), Gaps = 21/139 (15%)
Query: 157 EAQFRMLMDRLGAQK----VLED-----ESDVKQLWLQLKKEEPHLLSNFEDFLTRIIS- 206
E+Q ++L +RL A++ VL+ E VK+L +Q++ E H+ + R+ +
Sbjct: 1051 ESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKAL 1110
Query: 207 --QLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARS- 263
Q+ EA EE L+ L++K EE + E+++ +IKS L KD+ R +RS
Sbjct: 1111 KRQVDEAEEEIERLD-GLRKKAQREVEEQHEVNEQLQARIKS-----LEKDSWRKASRSA 1164
Query: 264 --QELEQKLLCKEQELEQL 280
L+ + L ++E + +
Sbjct: 1165 AESALKNEGLSSDEEFDSV 1183
Score = 37.0 bits (84), Expect = 0.038
Identities = 50/255 (19%), Positives = 104/255 (40%), Gaps = 40/255 (15%)
Query: 213 EEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLC 272
E +E E +++RK++ E++Q L K+ Q EL +K+
Sbjct: 324 EGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQ-------------GELTRKVEE 370
Query: 273 KEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQ 332
+++L++ +K+++LE L E E ++L+ + E ++++ ELQ+ ++
Sbjct: 371 LQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRL 430
Query: 333 LESLQQEACKLHQEKEMEVYRVTESLQR------EKAGLLKQLDFLRERNKHLRDERDIC 386
L+ + L E +V + L+ K LLK L RE + + + +
Sbjct: 431 LDQGED----LRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRV 486
Query: 387 FQKNKAAKANTAASRASWKKRSGSVIGKYVDSRGILRRWPQRDRGIPTLQYQTQRDLEDC 446
++ + + A + + K+ S RD+ + ++ Q QRD E
Sbjct: 487 EEQLRLRERELTALKGALKEEVAS-----------------RDQEVEHVRQQYQRDTEQL 529
Query: 447 KHEMKKICKAEVTLE 461
+ M+ + LE
Sbjct: 530 RRSMQDATQDHAVLE 544
Score = 36.2 bits (82), Expect = 0.064
Identities = 43/222 (19%), Positives = 102/222 (45%), Gaps = 18/222 (8%)
Query: 149 LGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNF----EDFLTRI 204
L + ++ E + R DR K LE++ + L +K LL++ D + ++
Sbjct: 943 LQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQL 1002
Query: 205 ISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQI-KSEKEQFLLKDTERFQARS 263
++L + + +LEC KI+ ++ ++++ ++ SE Q + ++++
Sbjct: 1003 RTELMQERSARQDLECD---KIS-----LERQNKDLKTRLASSEGFQKPSASLSQLESQN 1054
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTAL----HHDKHETKAENTKLKLTNQELAREL 319
Q L+++L +E+E L ++LE + L ++ + +L L + L R++
Sbjct: 1055 QLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQV 1114
Query: 320 ERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQRE 361
+ E++ + Q+E + H+ E R+ +SL+++
Sbjct: 1115 DEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARI-KSLEKD 1155
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 60.8 bits (146), Expect = 2e-09
Identities = 72/334 (21%), Positives = 145/334 (43%), Gaps = 33/334 (9%)
Query: 81 ELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKV 140
E+ L+++EL+ + +L PQ T + Q +E E+ ++ EEK+
Sbjct: 205 EIQLNVKELKRKLERAK-----FLLPQVQTNTLQEEMWRQEEELREQ--EKKIRKQEEKM 257
Query: 141 YLS--RGDEDLGDMGEDEEA-------------QFRMLMDRLGAQKVLEDESDVKQLWLQ 185
+ R E G M E EE + R L QK L ++ + Q +
Sbjct: 258 WRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEE 317
Query: 186 LKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALK---RKIAAYDEEIQHLYEEMEQ 242
E+ + E+ + R +L E ++ E E ++ ++ DE ++ E M +
Sbjct: 318 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMRE 377
Query: 243 QIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETK 302
Q K +++ +++ ER + R +++ ++ +E EQ + QK+ E + + +
Sbjct: 378 QEKMWEQEEKMQEEERIREREKKMREE---EETMREQEEKMQKQEENMWEQEEKEWQQQR 434
Query: 303 AENTKLKLTNQELARELERTSWELQD-AQQQLESLQQEACKLHQEK----EMEVYRVTES 357
K KL QE +E E WE ++ + Q E QE QEK E +++ E
Sbjct: 435 LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 494
Query: 358 LQREKAGLLKQLDFLRERNKHLRDERDICFQKNK 391
++ ++ + Q + + E+++ LR++ + ++ K
Sbjct: 495 MRDQEQKMWDQEERMWEQDERLREKEERMREQKK 528
Score = 53.1 bits (126), Expect = 5e-07
Identities = 54/279 (19%), Positives = 136/279 (48%), Gaps = 30/279 (10%)
Query: 120 QNNPSQEDA--GEQVAQRHEEKVYLSRGD-EDLGDMGEDEEAQFRMLMDRLGAQKVLEDE 176
Q P Q++ ++ Q EEK++ D +M E+ +R +K+ E E
Sbjct: 433 QRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ-------EKMREQE 485
Query: 177 SDVKQLWLQLKK--EEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQ 234
Q+W Q +K ++ + + E+ + +L+E E E ++K+ +E+++
Sbjct: 486 D---QMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMRE-----QKKMWQQEEKMR 537
Query: 235 HLYEEMEQQIKSEKEQFLLKDTERFQARSQEL-EQKLLCKEQELEQLTQKQKRLEGQCTA 293
+ EQ+ K+ ++ +++ ER + R +++ E++ + +EQE E++ ++++++ Q
Sbjct: 538 EEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE-EKMQEQEEKMREQEEK 596
Query: 294 LHHDKHETKAENTKL-----KLTNQE---LARELERTSWELQDAQQQLESLQQEACKLHQ 345
+ + + + + K+ K+ QE +E E WE ++ Q+ E E + +
Sbjct: 597 MWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMR 656
Query: 346 EKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERD 384
E+E ++ E +Q ++ + +Q + ++ + + +R++ +
Sbjct: 657 EQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEE 695
Score = 52.4 bits (124), Expect = 9e-07
Identities = 53/198 (26%), Positives = 102/198 (51%), Gaps = 18/198 (9%)
Query: 207 QLQEAHEEKNELEC---ALKRKIAAY-----DEEIQHLYEEMEQQIKS--EKEQFLLKDT 256
+L+ A EK+E++ LKRK+ + L EEM +Q + E+E+ + K
Sbjct: 195 KLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQE 254
Query: 257 ERFQARSQEL-EQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL 315
E+ + + L EQ+ +EQE E++ +++KRL Q L + E + E KL+ +E
Sbjct: 255 EKMWRQEERLREQEGKMREQE-EKMRRQEKRLREQEKELREQEKELR-EQKKLR-EQEEQ 311
Query: 316 ARELERTSWELQD--AQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLR 373
+E E WE ++ +Q+ + +QE QEK+M + ++ ++ + +Q + LR
Sbjct: 312 MQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR--EQEQKMRDQEERMWEQDERLR 369
Query: 374 ERNKHLRDERDICFQKNK 391
E+ + +R++ + Q+ K
Sbjct: 370 EKEERMREQEKMWEQEEK 387
Score = 52.4 bits (124), Expect = 9e-07
Identities = 54/305 (17%), Positives = 143/305 (46%), Gaps = 35/305 (11%)
Query: 130 EQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRM--LMDRLGAQKVLEDES---------- 177
E+ + EEK + + +E++ + E E Q R+ ++L Q+ ++++
Sbjct: 405 EETMREQEEK--MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 462
Query: 178 -DVKQLWLQLKKE-EPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH 235
D +++W Q KK + ED Q+ E E+ + E + + E+ +
Sbjct: 463 RDQEEMWGQEKKMWRQEKMREQED-------QMWEQEEKMRDQEQKMWDQEERMWEQDER 515
Query: 236 LYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQEL---EQLTQKQKRLEGQCT 292
L E+ E++++ +K+ + ++ R + ++QE E+K +E+++ E++ +++K++ +
Sbjct: 516 LREK-EERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 574
Query: 293 ALHHDKHETKAENTKLK------LTNQELARELERTSWELQDA--QQQLESLQQEACKLH 344
+ + + + + K++ +E +E E WE ++ +Q+ E QE ++
Sbjct: 575 MMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMM 634
Query: 345 QEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASW 404
E+E ++ E + ++ + +Q + +RE+ + ++ + + ++ + + R
Sbjct: 635 WEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQE 694
Query: 405 KKRSG 409
+K G
Sbjct: 695 EKMRG 699
Score = 49.7 bits (117), Expect = 6e-06
Identities = 42/199 (21%), Positives = 103/199 (51%), Gaps = 11/199 (5%)
Query: 214 EKNELECALKRKIAAYDE-EIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLC 272
+K E K ++A ++ EIQ +E+++++ E+ +FLL + + + Q+
Sbjct: 186 KKKNAELQEKLRLAESEKSEIQLNVKELKRKL--ERAKFLLPQVQTNTLQEEMWRQEEEL 243
Query: 273 KEQEL------EQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWEL 326
+EQE E++ ++++RL Q + + + + + +L+ +EL RE E+ E
Sbjct: 244 REQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKEL-REQEKELREQ 302
Query: 327 QDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDIC 386
+ ++Q E +Q++ K+ +++E ++ E + R++ L +Q +RE+ + +RD+ +
Sbjct: 303 KKLREQEEQMQEQEEKMWEQEE-KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERM 361
Query: 387 FQKNKAAKANTAASRASWK 405
+++++ + R K
Sbjct: 362 WEQDERLREKEERMREQEK 380
Score = 49.3 bits (116), Expect = 7e-06
Identities = 46/253 (18%), Positives = 117/253 (46%), Gaps = 25/253 (9%)
Query: 130 EQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKK- 188
EQ EE+++ DE L + E Q +M ++ + + K+ W Q +K
Sbjct: 499 EQKMWDQEERMW--EQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKM 556
Query: 189 -------EEPHLLSNFEDFLTRIISQLQEAHEEKNELECAL---KRKIAAYDEEI----Q 234
E + E+ + ++QE E+ E E + + K+ +E++ +
Sbjct: 557 REEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEE 616
Query: 235 HLYEEMEQQIKSEKEQFLLKDTERFQARSQEL-EQKLLCKEQELEQLTQKQKRLEGQCTA 293
++E+ E+ E+E+ + + E+ Q + +++ EQ+ +EQE E++ +++++++GQ
Sbjct: 617 KMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQE-EKMREQEEKMQGQEEK 675
Query: 294 LHHDKHETKAENTKLKLTNQELARELER------TSWELQDAQQQLESLQQEACKLHQEK 347
+ + + + + K++ +++ + E+ W ++ E ++++ ++ +K
Sbjct: 676 MREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQK 735
Query: 348 EMEVYRVTESLQR 360
E R+ E +R
Sbjct: 736 EKMQERLPEHEER 748
Score = 45.1 bits (105), Expect = 1e-04
Identities = 51/273 (18%), Positives = 127/273 (46%), Gaps = 27/273 (9%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGE---DEEAQFRMLMDRLGAQKVLEDESDVKQ 181
QE EQ Q E++ + ++ + D E +++ + R +R+ QK +
Sbjct: 478 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQK---------K 528
Query: 182 LWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEME 241
+W Q +K + ++ T + E E E +K+ +E ++ E+M+
Sbjct: 529 MWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRERE----KKMREEEEMMREQEEKMQ 584
Query: 242 QQIKS--EKEQFLLKDTERFQARSQEL-EQKLLCKEQELEQLTQKQKRLEGQCTALHHDK 298
+Q + E+E+ + + E+ Q + +++ EQ+ EQE E Q+Q+ + + ++
Sbjct: 585 EQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQ 644
Query: 299 HETKAE-NTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEM------EV 351
E E K++ +++ + E+ + + ++Q E +Q + K+ +++E ++
Sbjct: 645 EEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKM 704
Query: 352 YRVTESLQREKAGLLKQLDFLRERNKHLRDERD 384
+ E + ++ + Q + +RE+ + +RD+++
Sbjct: 705 WGQEEKMWGQEEKMWGQ-EEMREKEERIRDQKE 736
Score = 39.7 bits (91), Expect = 0.006
Identities = 34/147 (23%), Positives = 70/147 (47%), Gaps = 5/147 (3%)
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTS 323
+EL ++ EL + T + L+ + L ++E ++++L +EL R+LER
Sbjct: 162 EELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAK 221
Query: 324 WELQDAQQQLESLQQEACKLHQE---KEMEVYRVTESLQREKAGLLKQLDFLRERNKHLR 380
+ L Q Q +LQ+E + +E +E ++ + E + R++ L +Q +RE+ + +R
Sbjct: 222 FLLP--QVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMR 279
Query: 381 DERDICFQKNKAAKANTAASRASWKKR 407
+ ++ K + R K R
Sbjct: 280 RQEKRLREQEKELREQEKELREQKKLR 306
Score = 38.9 bits (89), Expect = 0.010
Identities = 40/197 (20%), Positives = 91/197 (46%), Gaps = 23/197 (11%)
Query: 204 IISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDT---ERFQ 260
+ +L + EL+ AL ++ + ++ EE+ ++ + L ++T E +
Sbjct: 129 LAGRLHHSWHFAGELQRALSA-VSTWHKKADRYIEELTKE-RDALSLELYRNTITNEELK 186
Query: 261 ARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQE---LAR 317
++ EL++KL E E ++ K L + K E K L + L
Sbjct: 187 KKNAELQEKLRLAESEKSEIQLNVKEL------------KRKLERAKFLLPQVQTNTLQE 234
Query: 318 ELERTSWELQDAQQQLESLQQEACKLHQ---EKEMEVYRVTESLQREKAGLLKQLDFLRE 374
E+ R EL++ ++++ +++ + + E+E ++ E ++R++ L +Q LRE
Sbjct: 235 EMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELRE 294
Query: 375 RNKHLRDERDICFQKNK 391
+ K LR+++ + Q+ +
Sbjct: 295 QEKELREQKKLREQEEQ 311
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 60.8 bits (146), Expect = 2e-09
Identities = 54/255 (21%), Positives = 131/255 (51%), Gaps = 15/255 (5%)
Query: 130 EQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKE 189
E++ EEK+ R E++ M E EE + R L +++ Q+ + ++ + +Q +++++
Sbjct: 416 EEMMWEKEEKM---RRQEEM--MWEKEE-KIRELEEKMHEQEKIREQEEKRQEEEKIREQ 469
Query: 190 EPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE 249
E E + R +++E E+ E E + R+ EE H E++ ++ K +++
Sbjct: 470 EKR--QEQEAKMWRQEEKIREQEEKIREQEEKMWRQ-----EEKIHEQEKIREEEKRQEQ 522
Query: 250 QFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLK 309
+ + + E+ + + + QK EQE E++ ++++++ Q +H + + + + K+
Sbjct: 523 EEMWRQEEKIREQEEIWRQKEKIHEQE-EKIRKQEEKMWRQEEKMHDQEEKIREQEEKV- 580
Query: 310 LTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQL 369
+E RE E E ++ ++ E + QE + E+E ++ E +Q ++ + +Q
Sbjct: 581 WRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQE 640
Query: 370 DFLRERNKHLRDERD 384
+ +RE+ K +R++ +
Sbjct: 641 EKIREQEKKIREQEE 655
Score = 58.9 bits (141), Expect = 9e-09
Identities = 53/257 (20%), Positives = 126/257 (49%), Gaps = 21/257 (8%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
+E EQ + E++ + R +E + + + E + R + + Q+ E + +++W
Sbjct: 483 EEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE--EKIREQEEIWR 540
Query: 185 QLKK--EEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQ 242
Q +K E+ + E+ + R ++ + E+ E E K+ +E+I+ E++ +
Sbjct: 541 QKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQE----EKVWRQEEKIREQEEKIRE 596
Query: 243 QIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETK 302
Q + +EQ + T+ + + E E+K+ +E+++++ +K +R E + + + + +
Sbjct: 597 QEEKIREQEEM--TQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEK---IREQEKKIR 651
Query: 303 AENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREK 362
+ K++ +E+ +E E WE ++ + E QE QE++M R E + ++
Sbjct: 652 EQEEKIR-EQEEMMQEQEEKMWEQEEKMCEQEEKMQE-----QEEKMR--RQEEKMWEQE 703
Query: 363 AGLLKQLDFLRERNKHL 379
L +Q + ++E +HL
Sbjct: 704 VRLRQQEEKMQEHQEHL 720
Score = 55.1 bits (131), Expect = 1e-07
Identities = 54/286 (18%), Positives = 128/286 (44%), Gaps = 19/286 (6%)
Query: 112 GFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQK 171
G + S+ + S + AGE + D + ++ ++ +A L +
Sbjct: 219 GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE 278
Query: 172 VLEDESDVKQLWLQL-KKEEPHLLSNFEDFL-----TRIISQLQEAHEEKNELECALKRK 225
L++++ Q LQL + E+ + N ++ +++ Q+ E + L L+
Sbjct: 279 ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 338
Query: 226 IAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQA---RSQELEQKLLCKEQELEQLTQ 282
A +++ E+ ++ ++E+ + + E+ Q + QE E+K+ +E+++ + +
Sbjct: 339 SAKLQAQVEE--NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEE 396
Query: 283 KQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACK 342
K +R E + +K E ++ +E R E WE ++ ++LE E K
Sbjct: 397 KMRRQE----EMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 452
Query: 343 LHQEKEM----EVYRVTESLQREKAGLLKQLDFLRERNKHLRDERD 384
+ +++E E R E Q ++A + +Q + +RE+ + +R++ +
Sbjct: 453 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEE 498
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 60.8 bits (146), Expect = 2e-09
Identities = 70/294 (23%), Positives = 141/294 (47%), Gaps = 26/294 (8%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
+E A EQ + E+K E + +E F+ ++ Q+ LE ++ ++L L
Sbjct: 2336 KELAQEQARRLQEDK-------EQMAQQLAEETQGFQRTLEA-ERQRQLEMSAEAERLKL 2387
Query: 185 QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDE-EIQ-----HLYE 238
++ E + E+ R Q +E E+ + E A + K+ EIQ H E
Sbjct: 2388 RVA-EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2446
Query: 239 EMEQ---QIKSEKEQFLLKDTERFQARSQELE----QKLLCKEQELEQ--LTQKQKRLEG 289
+ + +++ EKE+ L ++ + Q +S+E++ ++LL + Q L+Q L++K L+
Sbjct: 2447 RLREAIAELEREKEK-LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 290 QCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEM 349
+ + +K + + Q+L E +R +++ +Q+L + +EA + E E
Sbjct: 2506 E-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Query: 350 EVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRAS 403
V R E LQ+ + +Q + L E N+ LR++ + ++++AA A++ AS
Sbjct: 2565 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2618
Score = 60.1 bits (144), Expect = 4e-09
Identities = 71/342 (20%), Positives = 150/342 (43%), Gaps = 22/342 (6%)
Query: 124 SQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQ-- 181
+Q A + ++ E+ R + + + + A M + A++ L ++ V+Q
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188
Query: 182 --LWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEE 239
L LQL+ E H + ++ L R+ ++ EA +++++E L + EE+ L
Sbjct: 2189 TTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF-SVRVQMEELSKL--- 2243
Query: 240 MEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKH 299
+ +I++E +L+D + Q QE +K+ +E +L+ + D
Sbjct: 2244 -KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302
Query: 300 ETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQ 359
+ +A K+ + +E R E + QQQ E Q++A +L ++KE ++ + L
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE----QMAQQLA 2358
Query: 360 REKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWK----KRSGSVIGKY 415
E G + L+ R+R + E + K + A+ + A +RA ++ IG+
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416
Query: 416 VDSRGILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKKICKAE 457
+ + + ++ + TL+ Q Q+ D + + I + E
Sbjct: 2417 LHRTELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Score = 50.1 bits (118), Expect = 4e-06
Identities = 94/421 (22%), Positives = 164/421 (38%), Gaps = 89/421 (21%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGD----EDLGDMGEDEEAQFRMLMDRLGAQKVLED 175
Q +E A + A E L + E + ED Q R + + + A K +
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 176 ESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH 235
++ + L+L E + SN ED L +E+ ELE A +R++AA +E +
Sbjct: 1936 KAAAGKAELEL--ELGRIRSNAEDTLRS---------KEQAELEAARQRQLAAEEERRRR 1984
Query: 236 LYEEMEQQIKSEKEQFL------LKDTERFQAR---------------------SQELEQ 268
EE Q+ + +E+ L++ ER +A+ +QE Q
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044
Query: 269 KLLC------------KEQELEQLTQKQK----RLEGQCTALHHDKHETKAENTKLKLTN 312
K L KEQEL+Q Q+++ +L G+ A E + + +
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 313 QELARELERTSWELQDAQQQLES---LQQEACKLHQEKEMEVYRVTESLQ---------- 359
+ R++E Q A++Q ++ Q A KL +E E E R ++ Q
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Query: 360 --------------REKAGLLKQLDFLR---ERNKHLRDERDICFQKNKAAKANTAASRA 402
R+KA + ++L LR E H ++ D Q+ KA A R+
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 403 SWKKRSGSVIGKYVDSRGILRRWPQRDRG-IPTLQYQTQRDLEDCKHEMKKICKAEVTLE 461
++ SV + + + R +R I + TQR L++ +MK++ + L
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284
Query: 462 M 462
+
Sbjct: 2285 V 2285
Score = 49.7 bits (117), Expect = 6e-06
Identities = 56/296 (18%), Positives = 131/296 (44%), Gaps = 18/296 (6%)
Query: 165 DRLGAQKVLEDESDVKQLWLQLKKE----EPHLLSNF--EDFLTRIISQLQEAHEEKNEL 218
+RL Q+ E+ + ++ L+K+ E H + E + ++QE + E
Sbjct: 1348 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1407
Query: 219 ECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELE 278
+++ + EE+Q L + E +I+++ Q + R + +E+++ +LE
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR-----IEEEIRVVRLQLE 1462
Query: 279 QLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQ 338
+++ EG+ AL E +A+ + + + L R+++ S + A+ +L S +
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522
Query: 339 EACKLHQEKEMEVYRVTE-SLQREKA-GLLKQLDFLRERNKHLRDERDICFQKNKAAKAN 396
+ +EK+ + + E LQ E+A L+Q + R R + E ++A+A
Sbjct: 1523 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-----TAQRSAEAE 1577
Query: 397 TAASRASWKKRSGSVIGKYVDSRGILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKK 452
+ RAS+ +++ + + + + + Q + +R E+ + E+++
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/180 (24%), Positives = 75/180 (41%), Gaps = 11/180 (6%)
Query: 180 KQLWLQLKKEEPHL-LSNFEDFLTRIISQLQEAHEEKNELECALKR---------KIAAY 229
K L+ +E H+ ++ + R Q EA + E E L+R ++
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 230 DEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEG 289
EE+ + + + +KE+ + R +A Q + Q+ L EQELE+ Q +
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA-EQELEKQRQLAEGTAQ 1706
Query: 290 QCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEM 349
Q A + +AE + + Q L EL R E A Q+ + L+ E K+ E E+
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1766
Score = 43.9 bits (102), Expect = 3e-04
Identities = 65/297 (21%), Positives = 127/297 (42%), Gaps = 24/297 (8%)
Query: 126 EDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQ 185
E+A A E K +ED + E + +G L+ E+++ +
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860
Query: 186 LKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH----LYEEME 241
+ E L+ E F R + ++A + K ++E L + A D E++ + + +
Sbjct: 1861 AENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1918
Query: 242 QQIKSEKEQFLLKDT-ERFQARSQEL-----------EQKLLCKEQ-ELEQLTQKQKRLE 288
Q+ + E+E LK + E+ A EL E L KEQ ELE Q+Q E
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978
Query: 289 GQCTALHHDKHETKAENTKLKLTNQELA--RELERTSWELQDAQQQLESLQQEACKLHQE 346
+ ++ K+ + + Q A E+ER ++++A++ E +QE+ + Q
Sbjct: 1979 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2038
Query: 347 KEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQ-KNKAAKANTAASRA 402
+ + ++ ++ A ++Q + +E + L+ E+ + Q + +A A AA A
Sbjct: 2039 AQEAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093
Score = 42.7 bits (99), Expect = 7e-04
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 14/163 (8%)
Query: 221 ALKRKIAAYDEEIQHLYEEMEQQ------IKSEKEQFLLKDTERFQARSQELEQKLLCKE 274
A K K+ + E + Y ++ + S+ +F+ + R + + EQ+ +
Sbjct: 1300 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ---RA 1356
Query: 275 QELEQLTQKQKRLEGQCT-ALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQL 333
+E E+L + + LE Q A H + + +AE +L Q + E+ R DAQQQ
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL-QQRMQEEVVRREEAAVDAQQQK 1415
Query: 334 ESLQQEACKLHQEKEMEVY---RVTESLQREKAGLLKQLDFLR 373
S+Q+E +L Q E E+ R E+ +R + + +++ +R
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Score = 40.4 bits (93), Expect = 0.003
Identities = 59/262 (22%), Positives = 117/262 (44%), Gaps = 33/262 (12%)
Query: 156 EEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEK 215
EEA+ R + A++ E+ + W E L E+ + EA ++K
Sbjct: 1608 EEAE-RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 216 NELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE-------QFLLKDTERFQARSQELEQ 268
E E +R+ A ++ ++ E EQ+++ +++ Q L + E + R+ E EQ
Sbjct: 1667 EEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-ETEQ 1724
Query: 269 KLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL----ARELERTSW 324
EQ+ + L ++ RL+ + A + E +AE K++ + L AR E +
Sbjct: 1725 G----EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 325 ELQDAQQQLES-------LQQEACKLH---QEKEMEVYRVTESLQREKAG----LLKQLD 370
+ ++Q+LE+ L +EA +L +E + + E R++A L ++L
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 371 FLRERNKHLRDERDICFQKNKA 392
+ E + L+ E +I ++ +A
Sbjct: 1841 AIGEATR-LKTEAEIALKEKEA 1861
Score = 36.2 bits (82), Expect = 0.064
Identities = 61/259 (23%), Positives = 115/259 (44%), Gaps = 38/259 (14%)
Query: 125 QEDAGEQVAQRHEEKVYLSRG----DEDLGDMGEDEEAQFRMLMDRLGA--QKVLEDESD 178
Q+ E+V +R E V + E+L + + EA+ + + A + L E +
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 179 VKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYE 238
++ + LQL+ E E L + ++ +EA +K + + +R +E Q +
Sbjct: 1454 IRVVRLQLEATERQR-GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512
Query: 239 ---EMEQQIKSEKE-----QFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEG- 289
E+ ++K+E E Q L+ E + +++E E++L ++ E+E+ Q Q LE
Sbjct: 1513 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL--RQAEVERARQVQVALETA 1570
Query: 290 --QCTALHHDKHETKAENT-KLKLTNQE-------LARELERTSWEL-------QDAQQQ 332
A K + AE T +L+ + QE L E ER + + ++A+++
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1630
Query: 333 LESLQ---QEACKLHQEKE 348
LE Q EA +L + E
Sbjct: 1631 LERWQLKANEALRLRLQAE 1649
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 60.8 bits (146), Expect = 2e-09
Identities = 70/294 (23%), Positives = 141/294 (47%), Gaps = 26/294 (8%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
+E A EQ + E+K E + +E F+ ++ Q+ LE ++ ++L L
Sbjct: 2340 KELAQEQARRLQEDK-------EQMAQQLAEETQGFQRTLEA-ERQRQLEMSAEAERLKL 2391
Query: 185 QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDE-EIQ-----HLYE 238
++ E + E+ R Q +E E+ + E A + K+ EIQ H E
Sbjct: 2392 RVA-EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2450
Query: 239 EMEQ---QIKSEKEQFLLKDTERFQARSQELE----QKLLCKEQELEQ--LTQKQKRLEG 289
+ + +++ EKE+ L ++ + Q +S+E++ ++LL + Q L+Q L++K L+
Sbjct: 2451 RLREAIAELEREKEK-LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2509
Query: 290 QCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEM 349
+ + +K + + Q+L E +R +++ +Q+L + +EA + E E
Sbjct: 2510 E-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2568
Query: 350 EVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRAS 403
V R E LQ+ + +Q + L E N+ LR++ + ++++AA A++ AS
Sbjct: 2569 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2622
Score = 60.1 bits (144), Expect = 4e-09
Identities = 71/342 (20%), Positives = 150/342 (43%), Gaps = 22/342 (6%)
Query: 124 SQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQ-- 181
+Q A + ++ E+ R + + + + A M + A++ L ++ V+Q
Sbjct: 2133 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2192
Query: 182 --LWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEE 239
L LQL+ E H + ++ L R+ ++ EA +++++E L + EE+ L
Sbjct: 2193 TTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF-SVRVQMEELSKL--- 2247
Query: 240 MEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKH 299
+ +I++E +L+D + Q QE +K+ +E +L+ + D
Sbjct: 2248 -KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2306
Query: 300 ETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQ 359
+ +A K+ + +E R E + QQQ E Q++A +L ++KE ++ + L
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE----QMAQQLA 2362
Query: 360 REKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWK----KRSGSVIGKY 415
E G + L+ R+R + E + K + A+ + A +RA ++ IG+
Sbjct: 2363 EETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2420
Query: 416 VDSRGILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKKICKAE 457
+ + + ++ + TL+ Q Q+ D + + I + E
Sbjct: 2421 LHRTELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460
Score = 50.1 bits (118), Expect = 4e-06
Identities = 94/421 (22%), Positives = 164/421 (38%), Gaps = 89/421 (21%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGD----EDLGDMGEDEEAQFRMLMDRLGAQKVLED 175
Q +E A + A E L + E + ED Q R + + + A K +
Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1939
Query: 176 ESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH 235
++ + L+L E + SN ED L +E+ ELE A +R++AA +E +
Sbjct: 1940 KAAAGKAELEL--ELGRIRSNAEDTLRS---------KEQAELEAARQRQLAAEEERRRR 1988
Query: 236 LYEEMEQQIKSEKEQFL------LKDTERFQAR---------------------SQELEQ 268
EE Q+ + +E+ L++ ER +A+ +QE Q
Sbjct: 1989 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2048
Query: 269 KLLC------------KEQELEQLTQKQK----RLEGQCTALHHDKHETKAENTKLKLTN 312
K L KEQEL+Q Q+++ +L G+ A E + + +
Sbjct: 2049 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2108
Query: 313 QELARELERTSWELQDAQQQLES---LQQEACKLHQEKEMEVYRVTESLQ---------- 359
+ R++E Q A++Q ++ Q A KL +E E E R ++ Q
Sbjct: 2109 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2168
Query: 360 --------------REKAGLLKQLDFLR---ERNKHLRDERDICFQKNKAAKANTAASRA 402
R+KA + ++L LR E H ++ D Q+ KA A R+
Sbjct: 2169 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2228
Query: 403 SWKKRSGSVIGKYVDSRGILRRWPQRDRG-IPTLQYQTQRDLEDCKHEMKKICKAEVTLE 461
++ SV + + + R +R I + TQR L++ +MK++ + L
Sbjct: 2229 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2288
Query: 462 M 462
+
Sbjct: 2289 V 2289
Score = 49.7 bits (117), Expect = 6e-06
Identities = 56/296 (18%), Positives = 131/296 (44%), Gaps = 18/296 (6%)
Query: 165 DRLGAQKVLEDESDVKQLWLQLKKE----EPHLLSNF--EDFLTRIISQLQEAHEEKNEL 218
+RL Q+ E+ + ++ L+K+ E H + E + ++QE + E
Sbjct: 1352 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1411
Query: 219 ECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELE 278
+++ + EE+Q L + E +I+++ Q + R + +E+++ +LE
Sbjct: 1412 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR-----IEEEIRVVRLQLE 1466
Query: 279 QLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQ 338
+++ EG+ AL E +A+ + + + L R+++ S + A+ +L S +
Sbjct: 1467 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1526
Query: 339 EACKLHQEKEMEVYRVTE-SLQREKA-GLLKQLDFLRERNKHLRDERDICFQKNKAAKAN 396
+ +EK+ + + E LQ E+A L+Q + R R + E ++A+A
Sbjct: 1527 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-----TAQRSAEAE 1581
Query: 397 TAASRASWKKRSGSVIGKYVDSRGILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKK 452
+ RAS+ +++ + + + + + Q + +R E+ + E+++
Sbjct: 1582 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/180 (24%), Positives = 75/180 (41%), Gaps = 11/180 (6%)
Query: 180 KQLWLQLKKEEPHL-LSNFEDFLTRIISQLQEAHEEKNELECALKR---------KIAAY 229
K L+ +E H+ ++ + R Q EA + E E L+R ++
Sbjct: 1592 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1651
Query: 230 DEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEG 289
EE+ + + + +KE+ + R +A Q + Q+ L EQELE+ Q +
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA-EQELEKQRQLAEGTAQ 1710
Query: 290 QCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEM 349
Q A + +AE + + Q L EL R E A Q+ + L+ E K+ E E+
Sbjct: 1711 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1770
Score = 43.9 bits (102), Expect = 3e-04
Identities = 65/297 (21%), Positives = 127/297 (42%), Gaps = 24/297 (8%)
Query: 126 EDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQ 185
E+A A E K +ED + E + +G L+ E+++ +
Sbjct: 1805 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1864
Query: 186 LKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH----LYEEME 241
+ E L+ E F R + ++A + K ++E L + A D E++ + + +
Sbjct: 1865 AENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1922
Query: 242 QQIKSEKEQFLLKDT-ERFQARSQEL-----------EQKLLCKEQ-ELEQLTQKQKRLE 288
Q+ + E+E LK + E+ A EL E L KEQ ELE Q+Q E
Sbjct: 1923 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1982
Query: 289 GQCTALHHDKHETKAENTKLKLTNQELA--RELERTSWELQDAQQQLESLQQEACKLHQE 346
+ ++ K+ + + Q A E+ER ++++A++ E +QE+ + Q
Sbjct: 1983 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2042
Query: 347 KEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQ-KNKAAKANTAASRA 402
+ + ++ ++ A ++Q + +E + L+ E+ + Q + +A A AA A
Sbjct: 2043 AQEAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2097
Score = 42.7 bits (99), Expect = 7e-04
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 14/163 (8%)
Query: 221 ALKRKIAAYDEEIQHLYEEMEQQ------IKSEKEQFLLKDTERFQARSQELEQKLLCKE 274
A K K+ + E + Y ++ + S+ +F+ + R + + EQ+ +
Sbjct: 1304 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ---RA 1360
Query: 275 QELEQLTQKQKRLEGQCT-ALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQL 333
+E E+L + + LE Q A H + + +AE +L Q + E+ R DAQQQ
Sbjct: 1361 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL-QQRMQEEVVRREEAAVDAQQQK 1419
Query: 334 ESLQQEACKLHQEKEMEVY---RVTESLQREKAGLLKQLDFLR 373
S+Q+E +L Q E E+ R E+ +R + + +++ +R
Sbjct: 1420 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462
Score = 40.4 bits (93), Expect = 0.003
Identities = 59/262 (22%), Positives = 117/262 (44%), Gaps = 33/262 (12%)
Query: 156 EEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEK 215
EEA+ R + A++ E+ + W E L E+ + EA ++K
Sbjct: 1612 EEAE-RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1670
Query: 216 NELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE-------QFLLKDTERFQARSQELEQ 268
E E +R+ A ++ ++ E EQ+++ +++ Q L + E + R+ E EQ
Sbjct: 1671 EEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-ETEQ 1728
Query: 269 KLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL----ARELERTSW 324
EQ+ + L ++ RL+ + A + E +AE K++ + L AR E +
Sbjct: 1729 G----EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784
Query: 325 ELQDAQQQLES-------LQQEACKLH---QEKEMEVYRVTESLQREKAG----LLKQLD 370
+ ++Q+LE+ L +EA +L +E + + E R++A L ++L
Sbjct: 1785 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1844
Query: 371 FLRERNKHLRDERDICFQKNKA 392
+ E + L+ E +I ++ +A
Sbjct: 1845 AIGEATR-LKTEAEIALKEKEA 1865
Score = 36.2 bits (82), Expect = 0.064
Identities = 61/259 (23%), Positives = 115/259 (44%), Gaps = 38/259 (14%)
Query: 125 QEDAGEQVAQRHEEKVYLSRG----DEDLGDMGEDEEAQFRMLMDRLGA--QKVLEDESD 178
Q+ E+V +R E V + E+L + + EA+ + + A + L E +
Sbjct: 1398 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1457
Query: 179 VKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYE 238
++ + LQL+ E E L + ++ +EA +K + + +R +E Q +
Sbjct: 1458 IRVVRLQLEATERQR-GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1516
Query: 239 ---EMEQQIKSEKE-----QFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEG- 289
E+ ++K+E E Q L+ E + +++E E++L ++ E+E+ Q Q LE
Sbjct: 1517 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL--RQAEVERARQVQVALETA 1574
Query: 290 --QCTALHHDKHETKAENT-KLKLTNQE-------LARELERTSWEL-------QDAQQQ 332
A K + AE T +L+ + QE L E ER + + ++A+++
Sbjct: 1575 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1634
Query: 333 LESLQ---QEACKLHQEKE 348
LE Q EA +L + E
Sbjct: 1635 LERWQLKANEALRLRLQAE 1653
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 60.8 bits (146), Expect = 2e-09
Identities = 70/294 (23%), Positives = 141/294 (47%), Gaps = 26/294 (8%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
+E A EQ + E+K E + +E F+ ++ Q+ LE ++ ++L L
Sbjct: 2336 KELAQEQARRLQEDK-------EQMAQQLAEETQGFQRTLEA-ERQRQLEMSAEAERLKL 2387
Query: 185 QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDE-EIQ-----HLYE 238
++ E + E+ R Q +E E+ + E A + K+ EIQ H E
Sbjct: 2388 RVA-EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2446
Query: 239 EMEQ---QIKSEKEQFLLKDTERFQARSQELE----QKLLCKEQELEQ--LTQKQKRLEG 289
+ + +++ EKE+ L ++ + Q +S+E++ ++LL + Q L+Q L++K L+
Sbjct: 2447 RLREAIAELEREKEK-LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 290 QCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEM 349
+ + +K + + Q+L E +R +++ +Q+L + +EA + E E
Sbjct: 2506 E-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Query: 350 EVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRAS 403
V R E LQ+ + +Q + L E N+ LR++ + ++++AA A++ AS
Sbjct: 2565 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2618
Score = 60.1 bits (144), Expect = 4e-09
Identities = 71/342 (20%), Positives = 150/342 (43%), Gaps = 22/342 (6%)
Query: 124 SQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQ-- 181
+Q A + ++ E+ R + + + + A M + A++ L ++ V+Q
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188
Query: 182 --LWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEE 239
L LQL+ E H + ++ L R+ ++ EA +++++E L + EE+ L
Sbjct: 2189 TTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF-SVRVQMEELSKL--- 2243
Query: 240 MEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKH 299
+ +I++E +L+D + Q QE +K+ +E +L+ + D
Sbjct: 2244 -KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302
Query: 300 ETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQ 359
+ +A K+ + +E R E + QQQ E Q++A +L ++KE ++ + L
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE----QMAQQLA 2358
Query: 360 REKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWK----KRSGSVIGKY 415
E G + L+ R+R + E + K + A+ + A +RA ++ IG+
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416
Query: 416 VDSRGILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKKICKAE 457
+ + + ++ + TL+ Q Q+ D + + I + E
Sbjct: 2417 LHRTELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Score = 50.1 bits (118), Expect = 4e-06
Identities = 94/421 (22%), Positives = 164/421 (38%), Gaps = 89/421 (21%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGD----EDLGDMGEDEEAQFRMLMDRLGAQKVLED 175
Q +E A + A E L + E + ED Q R + + + A K +
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 176 ESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH 235
++ + L+L E + SN ED L +E+ ELE A +R++AA +E +
Sbjct: 1936 KAAAGKAELEL--ELGRIRSNAEDTLRS---------KEQAELEAARQRQLAAEEERRRR 1984
Query: 236 LYEEMEQQIKSEKEQFL------LKDTERFQAR---------------------SQELEQ 268
EE Q+ + +E+ L++ ER +A+ +QE Q
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044
Query: 269 KLLC------------KEQELEQLTQKQK----RLEGQCTALHHDKHETKAENTKLKLTN 312
K L KEQEL+Q Q+++ +L G+ A E + + +
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 313 QELARELERTSWELQDAQQQLES---LQQEACKLHQEKEMEVYRVTESLQ---------- 359
+ R++E Q A++Q ++ Q A KL +E E E R ++ Q
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Query: 360 --------------REKAGLLKQLDFLR---ERNKHLRDERDICFQKNKAAKANTAASRA 402
R+KA + ++L LR E H ++ D Q+ KA A R+
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 403 SWKKRSGSVIGKYVDSRGILRRWPQRDRG-IPTLQYQTQRDLEDCKHEMKKICKAEVTLE 461
++ SV + + + R +R I + TQR L++ +MK++ + L
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284
Query: 462 M 462
+
Sbjct: 2285 V 2285
Score = 49.7 bits (117), Expect = 6e-06
Identities = 56/296 (18%), Positives = 131/296 (44%), Gaps = 18/296 (6%)
Query: 165 DRLGAQKVLEDESDVKQLWLQLKKE----EPHLLSNF--EDFLTRIISQLQEAHEEKNEL 218
+RL Q+ E+ + ++ L+K+ E H + E + ++QE + E
Sbjct: 1348 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1407
Query: 219 ECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELE 278
+++ + EE+Q L + E +I+++ Q + R + +E+++ +LE
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR-----IEEEIRVVRLQLE 1462
Query: 279 QLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQ 338
+++ EG+ AL E +A+ + + + L R+++ S + A+ +L S +
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522
Query: 339 EACKLHQEKEMEVYRVTE-SLQREKA-GLLKQLDFLRERNKHLRDERDICFQKNKAAKAN 396
+ +EK+ + + E LQ E+A L+Q + R R + E ++A+A
Sbjct: 1523 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-----TAQRSAEAE 1577
Query: 397 TAASRASWKKRSGSVIGKYVDSRGILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKK 452
+ RAS+ +++ + + + + + Q + +R E+ + E+++
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/180 (24%), Positives = 75/180 (41%), Gaps = 11/180 (6%)
Query: 180 KQLWLQLKKEEPHL-LSNFEDFLTRIISQLQEAHEEKNELECALKR---------KIAAY 229
K L+ +E H+ ++ + R Q EA + E E L+R ++
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 230 DEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEG 289
EE+ + + + +KE+ + R +A Q + Q+ L EQELE+ Q +
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA-EQELEKQRQLAEGTAQ 1706
Query: 290 QCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEM 349
Q A + +AE + + Q L EL R E A Q+ + L+ E K+ E E+
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1766
Score = 43.9 bits (102), Expect = 3e-04
Identities = 65/297 (21%), Positives = 127/297 (42%), Gaps = 24/297 (8%)
Query: 126 EDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQ 185
E+A A E K +ED + E + +G L+ E+++ +
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860
Query: 186 LKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH----LYEEME 241
+ E L+ E F R + ++A + K ++E L + A D E++ + + +
Sbjct: 1861 AENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1918
Query: 242 QQIKSEKEQFLLKDT-ERFQARSQEL-----------EQKLLCKEQ-ELEQLTQKQKRLE 288
Q+ + E+E LK + E+ A EL E L KEQ ELE Q+Q E
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978
Query: 289 GQCTALHHDKHETKAENTKLKLTNQELA--RELERTSWELQDAQQQLESLQQEACKLHQE 346
+ ++ K+ + + Q A E+ER ++++A++ E +QE+ + Q
Sbjct: 1979 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2038
Query: 347 KEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQ-KNKAAKANTAASRA 402
+ + ++ ++ A ++Q + +E + L+ E+ + Q + +A A AA A
Sbjct: 2039 AQEAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093
Score = 42.7 bits (99), Expect = 7e-04
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 14/163 (8%)
Query: 221 ALKRKIAAYDEEIQHLYEEMEQQ------IKSEKEQFLLKDTERFQARSQELEQKLLCKE 274
A K K+ + E + Y ++ + S+ +F+ + R + + EQ+ +
Sbjct: 1300 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ---RA 1356
Query: 275 QELEQLTQKQKRLEGQCT-ALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQL 333
+E E+L + + LE Q A H + + +AE +L Q + E+ R DAQQQ
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL-QQRMQEEVVRREEAAVDAQQQK 1415
Query: 334 ESLQQEACKLHQEKEMEVY---RVTESLQREKAGLLKQLDFLR 373
S+Q+E +L Q E E+ R E+ +R + + +++ +R
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Score = 40.4 bits (93), Expect = 0.003
Identities = 59/262 (22%), Positives = 117/262 (44%), Gaps = 33/262 (12%)
Query: 156 EEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEK 215
EEA+ R + A++ E+ + W E L E+ + EA ++K
Sbjct: 1608 EEAE-RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 216 NELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE-------QFLLKDTERFQARSQELEQ 268
E E +R+ A ++ ++ E EQ+++ +++ Q L + E + R+ E EQ
Sbjct: 1667 EEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-ETEQ 1724
Query: 269 KLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL----ARELERTSW 324
EQ+ + L ++ RL+ + A + E +AE K++ + L AR E +
Sbjct: 1725 G----EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 325 ELQDAQQQLES-------LQQEACKLH---QEKEMEVYRVTESLQREKAG----LLKQLD 370
+ ++Q+LE+ L +EA +L +E + + E R++A L ++L
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 371 FLRERNKHLRDERDICFQKNKA 392
+ E + L+ E +I ++ +A
Sbjct: 1841 AIGEATR-LKTEAEIALKEKEA 1861
Score = 36.2 bits (82), Expect = 0.064
Identities = 61/259 (23%), Positives = 115/259 (44%), Gaps = 38/259 (14%)
Query: 125 QEDAGEQVAQRHEEKVYLSRG----DEDLGDMGEDEEAQFRMLMDRLGA--QKVLEDESD 178
Q+ E+V +R E V + E+L + + EA+ + + A + L E +
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 179 VKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYE 238
++ + LQL+ E E L + ++ +EA +K + + +R +E Q +
Sbjct: 1454 IRVVRLQLEATERQR-GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512
Query: 239 ---EMEQQIKSEKE-----QFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEG- 289
E+ ++K+E E Q L+ E + +++E E++L ++ E+E+ Q Q LE
Sbjct: 1513 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL--RQAEVERARQVQVALETA 1570
Query: 290 --QCTALHHDKHETKAENT-KLKLTNQE-------LARELERTSWEL-------QDAQQQ 332
A K + AE T +L+ + QE L E ER + + ++A+++
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1630
Query: 333 LESLQ---QEACKLHQEKE 348
LE Q EA +L + E
Sbjct: 1631 LERWQLKANEALRLRLQAE 1649
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 60.8 bits (146), Expect = 2e-09
Identities = 70/294 (23%), Positives = 141/294 (47%), Gaps = 26/294 (8%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
+E A EQ + E+K E + +E F+ ++ Q+ LE ++ ++L L
Sbjct: 2304 KELAQEQARRLQEDK-------EQMAQQLAEETQGFQRTLEA-ERQRQLEMSAEAERLKL 2355
Query: 185 QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDE-EIQ-----HLYE 238
++ E + E+ R Q +E E+ + E A + K+ EIQ H E
Sbjct: 2356 RVA-EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2414
Query: 239 EMEQ---QIKSEKEQFLLKDTERFQARSQELE----QKLLCKEQELEQ--LTQKQKRLEG 289
+ + +++ EKE+ L ++ + Q +S+E++ ++LL + Q L+Q L++K L+
Sbjct: 2415 RLREAIAELEREKEK-LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2473
Query: 290 QCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEM 349
+ + +K + + Q+L E +R +++ +Q+L + +EA + E E
Sbjct: 2474 E-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2532
Query: 350 EVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRAS 403
V R E LQ+ + +Q + L E N+ LR++ + ++++AA A++ AS
Sbjct: 2533 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2586
Score = 60.1 bits (144), Expect = 4e-09
Identities = 71/342 (20%), Positives = 150/342 (43%), Gaps = 22/342 (6%)
Query: 124 SQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQ-- 181
+Q A + ++ E+ R + + + + A M + A++ L ++ V+Q
Sbjct: 2097 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2156
Query: 182 --LWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEE 239
L LQL+ E H + ++ L R+ ++ EA +++++E L + EE+ L
Sbjct: 2157 TTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF-SVRVQMEELSKL--- 2211
Query: 240 MEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKH 299
+ +I++E +L+D + Q QE +K+ +E +L+ + D
Sbjct: 2212 -KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2270
Query: 300 ETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQ 359
+ +A K+ + +E R E + QQQ E Q++A +L ++KE ++ + L
Sbjct: 2271 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE----QMAQQLA 2326
Query: 360 REKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWK----KRSGSVIGKY 415
E G + L+ R+R + E + K + A+ + A +RA ++ IG+
Sbjct: 2327 EETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2384
Query: 416 VDSRGILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKKICKAE 457
+ + + ++ + TL+ Q Q+ D + + I + E
Sbjct: 2385 LHRTELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424
Score = 50.1 bits (118), Expect = 4e-06
Identities = 94/421 (22%), Positives = 164/421 (38%), Gaps = 89/421 (21%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGD----EDLGDMGEDEEAQFRMLMDRLGAQKVLED 175
Q +E A + A E L + E + ED Q R + + + A K +
Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1903
Query: 176 ESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH 235
++ + L+L E + SN ED L +E+ ELE A +R++AA +E +
Sbjct: 1904 KAAAGKAELEL--ELGRIRSNAEDTLRS---------KEQAELEAARQRQLAAEEERRRR 1952
Query: 236 LYEEMEQQIKSEKEQFL------LKDTERFQAR---------------------SQELEQ 268
EE Q+ + +E+ L++ ER +A+ +QE Q
Sbjct: 1953 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2012
Query: 269 KLLC------------KEQELEQLTQKQK----RLEGQCTALHHDKHETKAENTKLKLTN 312
K L KEQEL+Q Q+++ +L G+ A E + + +
Sbjct: 2013 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2072
Query: 313 QELARELERTSWELQDAQQQLES---LQQEACKLHQEKEMEVYRVTESLQ---------- 359
+ R++E Q A++Q ++ Q A KL +E E E R ++ Q
Sbjct: 2073 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2132
Query: 360 --------------REKAGLLKQLDFLR---ERNKHLRDERDICFQKNKAAKANTAASRA 402
R+KA + ++L LR E H ++ D Q+ KA A R+
Sbjct: 2133 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2192
Query: 403 SWKKRSGSVIGKYVDSRGILRRWPQRDRG-IPTLQYQTQRDLEDCKHEMKKICKAEVTLE 461
++ SV + + + R +R I + TQR L++ +MK++ + L
Sbjct: 2193 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2252
Query: 462 M 462
+
Sbjct: 2253 V 2253
Score = 49.7 bits (117), Expect = 6e-06
Identities = 56/296 (18%), Positives = 131/296 (44%), Gaps = 18/296 (6%)
Query: 165 DRLGAQKVLEDESDVKQLWLQLKKE----EPHLLSNF--EDFLTRIISQLQEAHEEKNEL 218
+RL Q+ E+ + ++ L+K+ E H + E + ++QE + E
Sbjct: 1316 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1375
Query: 219 ECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELE 278
+++ + EE+Q L + E +I+++ Q + R + +E+++ +LE
Sbjct: 1376 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR-----IEEEIRVVRLQLE 1430
Query: 279 QLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQ 338
+++ EG+ AL E +A+ + + + L R+++ S + A+ +L S +
Sbjct: 1431 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1490
Query: 339 EACKLHQEKEMEVYRVTE-SLQREKA-GLLKQLDFLRERNKHLRDERDICFQKNKAAKAN 396
+ +EK+ + + E LQ E+A L+Q + R R + E ++A+A
Sbjct: 1491 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-----TAQRSAEAE 1545
Query: 397 TAASRASWKKRSGSVIGKYVDSRGILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKK 452
+ RAS+ +++ + + + + + Q + +R E+ + E+++
Sbjct: 1546 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/180 (24%), Positives = 75/180 (41%), Gaps = 11/180 (6%)
Query: 180 KQLWLQLKKEEPHL-LSNFEDFLTRIISQLQEAHEEKNELECALKR---------KIAAY 229
K L+ +E H+ ++ + R Q EA + E E L+R ++
Sbjct: 1556 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1615
Query: 230 DEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEG 289
EE+ + + + +KE+ + R +A Q + Q+ L EQELE+ Q +
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA-EQELEKQRQLAEGTAQ 1674
Query: 290 QCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEM 349
Q A + +AE + + Q L EL R E A Q+ + L+ E K+ E E+
Sbjct: 1675 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1734
Score = 43.9 bits (102), Expect = 3e-04
Identities = 65/297 (21%), Positives = 127/297 (42%), Gaps = 24/297 (8%)
Query: 126 EDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQ 185
E+A A E K +ED + E + +G L+ E+++ +
Sbjct: 1769 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1828
Query: 186 LKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH----LYEEME 241
+ E L+ E F R + ++A + K ++E L + A D E++ + + +
Sbjct: 1829 AENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1886
Query: 242 QQIKSEKEQFLLKDT-ERFQARSQEL-----------EQKLLCKEQ-ELEQLTQKQKRLE 288
Q+ + E+E LK + E+ A EL E L KEQ ELE Q+Q E
Sbjct: 1887 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1946
Query: 289 GQCTALHHDKHETKAENTKLKLTNQELA--RELERTSWELQDAQQQLESLQQEACKLHQE 346
+ ++ K+ + + Q A E+ER ++++A++ E +QE+ + Q
Sbjct: 1947 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2006
Query: 347 KEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQ-KNKAAKANTAASRA 402
+ + ++ ++ A ++Q + +E + L+ E+ + Q + +A A AA A
Sbjct: 2007 AQEAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2061
Score = 42.7 bits (99), Expect = 7e-04
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 14/163 (8%)
Query: 221 ALKRKIAAYDEEIQHLYEEMEQQ------IKSEKEQFLLKDTERFQARSQELEQKLLCKE 274
A K K+ + E + Y ++ + S+ +F+ + R + + EQ+ +
Sbjct: 1268 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ---RA 1324
Query: 275 QELEQLTQKQKRLEGQCT-ALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQL 333
+E E+L + + LE Q A H + + +AE +L Q + E+ R DAQQQ
Sbjct: 1325 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL-QQRMQEEVVRREEAAVDAQQQK 1383
Query: 334 ESLQQEACKLHQEKEMEVY---RVTESLQREKAGLLKQLDFLR 373
S+Q+E +L Q E E+ R E+ +R + + +++ +R
Sbjct: 1384 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426
Score = 40.4 bits (93), Expect = 0.003
Identities = 59/262 (22%), Positives = 117/262 (44%), Gaps = 33/262 (12%)
Query: 156 EEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEK 215
EEA+ R + A++ E+ + W E L E+ + EA ++K
Sbjct: 1576 EEAE-RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1634
Query: 216 NELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE-------QFLLKDTERFQARSQELEQ 268
E E +R+ A ++ ++ E EQ+++ +++ Q L + E + R+ E EQ
Sbjct: 1635 EEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-ETEQ 1692
Query: 269 KLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL----ARELERTSW 324
EQ+ + L ++ RL+ + A + E +AE K++ + L AR E +
Sbjct: 1693 G----EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1748
Query: 325 ELQDAQQQLES-------LQQEACKLH---QEKEMEVYRVTESLQREKAG----LLKQLD 370
+ ++Q+LE+ L +EA +L +E + + E R++A L ++L
Sbjct: 1749 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1808
Query: 371 FLRERNKHLRDERDICFQKNKA 392
+ E + L+ E +I ++ +A
Sbjct: 1809 AIGEATR-LKTEAEIALKEKEA 1829
Score = 36.2 bits (82), Expect = 0.064
Identities = 61/259 (23%), Positives = 115/259 (44%), Gaps = 38/259 (14%)
Query: 125 QEDAGEQVAQRHEEKVYLSRG----DEDLGDMGEDEEAQFRMLMDRLGA--QKVLEDESD 178
Q+ E+V +R E V + E+L + + EA+ + + A + L E +
Sbjct: 1362 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1421
Query: 179 VKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYE 238
++ + LQL+ E E L + ++ +EA +K + + +R +E Q +
Sbjct: 1422 IRVVRLQLEATERQR-GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1480
Query: 239 ---EMEQQIKSEKE-----QFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEG- 289
E+ ++K+E E Q L+ E + +++E E++L ++ E+E+ Q Q LE
Sbjct: 1481 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL--RQAEVERARQVQVALETA 1538
Query: 290 --QCTALHHDKHETKAENT-KLKLTNQE-------LARELERTSWEL-------QDAQQQ 332
A K + AE T +L+ + QE L E ER + + ++A+++
Sbjct: 1539 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1598
Query: 333 LESLQ---QEACKLHQEKE 348
LE Q EA +L + E
Sbjct: 1599 LERWQLKANEALRLRLQAE 1617
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 60.8 bits (146), Expect = 2e-09
Identities = 70/294 (23%), Positives = 141/294 (47%), Gaps = 26/294 (8%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
+E A EQ + E+K E + +E F+ ++ Q+ LE ++ ++L L
Sbjct: 2473 KELAQEQARRLQEDK-------EQMAQQLAEETQGFQRTLEA-ERQRQLEMSAEAERLKL 2524
Query: 185 QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDE-EIQ-----HLYE 238
++ E + E+ R Q +E E+ + E A + K+ EIQ H E
Sbjct: 2525 RVA-EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2583
Query: 239 EMEQ---QIKSEKEQFLLKDTERFQARSQELE----QKLLCKEQELEQ--LTQKQKRLEG 289
+ + +++ EKE+ L ++ + Q +S+E++ ++LL + Q L+Q L++K L+
Sbjct: 2584 RLREAIAELEREKEK-LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2642
Query: 290 QCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEM 349
+ + +K + + Q+L E +R +++ +Q+L + +EA + E E
Sbjct: 2643 E-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2701
Query: 350 EVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRAS 403
V R E LQ+ + +Q + L E N+ LR++ + ++++AA A++ AS
Sbjct: 2702 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2755
Score = 60.1 bits (144), Expect = 4e-09
Identities = 71/342 (20%), Positives = 150/342 (43%), Gaps = 22/342 (6%)
Query: 124 SQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQ-- 181
+Q A + ++ E+ R + + + + A M + A++ L ++ V+Q
Sbjct: 2266 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2325
Query: 182 --LWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEE 239
L LQL+ E H + ++ L R+ ++ EA +++++E L + EE+ L
Sbjct: 2326 TTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF-SVRVQMEELSKL--- 2380
Query: 240 MEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKH 299
+ +I++E +L+D + Q QE +K+ +E +L+ + D
Sbjct: 2381 -KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2439
Query: 300 ETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQ 359
+ +A K+ + +E R E + QQQ E Q++A +L ++KE ++ + L
Sbjct: 2440 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE----QMAQQLA 2495
Query: 360 REKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWK----KRSGSVIGKY 415
E G + L+ R+R + E + K + A+ + A +RA ++ IG+
Sbjct: 2496 EETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2553
Query: 416 VDSRGILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKKICKAE 457
+ + + ++ + TL+ Q Q+ D + + I + E
Sbjct: 2554 LHRTELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593
Score = 50.1 bits (118), Expect = 4e-06
Identities = 94/421 (22%), Positives = 164/421 (38%), Gaps = 89/421 (21%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGD----EDLGDMGEDEEAQFRMLMDRLGAQKVLED 175
Q +E A + A E L + E + ED Q R + + + A K +
Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 2072
Query: 176 ESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH 235
++ + L+L E + SN ED L +E+ ELE A +R++AA +E +
Sbjct: 2073 KAAAGKAELEL--ELGRIRSNAEDTLRS---------KEQAELEAARQRQLAAEEERRRR 2121
Query: 236 LYEEMEQQIKSEKEQFL------LKDTERFQAR---------------------SQELEQ 268
EE Q+ + +E+ L++ ER +A+ +QE Q
Sbjct: 2122 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2181
Query: 269 KLLC------------KEQELEQLTQKQK----RLEGQCTALHHDKHETKAENTKLKLTN 312
K L KEQEL+Q Q+++ +L G+ A E + + +
Sbjct: 2182 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2241
Query: 313 QELARELERTSWELQDAQQQLES---LQQEACKLHQEKEMEVYRVTESLQ---------- 359
+ R++E Q A++Q ++ Q A KL +E E E R ++ Q
Sbjct: 2242 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2301
Query: 360 --------------REKAGLLKQLDFLR---ERNKHLRDERDICFQKNKAAKANTAASRA 402
R+KA + ++L LR E H ++ D Q+ KA A R+
Sbjct: 2302 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2361
Query: 403 SWKKRSGSVIGKYVDSRGILRRWPQRDRG-IPTLQYQTQRDLEDCKHEMKKICKAEVTLE 461
++ SV + + + R +R I + TQR L++ +MK++ + L
Sbjct: 2362 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2421
Query: 462 M 462
+
Sbjct: 2422 V 2422
Score = 49.7 bits (117), Expect = 6e-06
Identities = 56/296 (18%), Positives = 131/296 (44%), Gaps = 18/296 (6%)
Query: 165 DRLGAQKVLEDESDVKQLWLQLKKE----EPHLLSNF--EDFLTRIISQLQEAHEEKNEL 218
+RL Q+ E+ + ++ L+K+ E H + E + ++QE + E
Sbjct: 1485 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1544
Query: 219 ECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELE 278
+++ + EE+Q L + E +I+++ Q + R + +E+++ +LE
Sbjct: 1545 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR-----IEEEIRVVRLQLE 1599
Query: 279 QLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQ 338
+++ EG+ AL E +A+ + + + L R+++ S + A+ +L S +
Sbjct: 1600 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1659
Query: 339 EACKLHQEKEMEVYRVTE-SLQREKA-GLLKQLDFLRERNKHLRDERDICFQKNKAAKAN 396
+ +EK+ + + E LQ E+A L+Q + R R + E ++A+A
Sbjct: 1660 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-----TAQRSAEAE 1714
Query: 397 TAASRASWKKRSGSVIGKYVDSRGILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKK 452
+ RAS+ +++ + + + + + Q + +R E+ + E+++
Sbjct: 1715 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/180 (24%), Positives = 75/180 (41%), Gaps = 11/180 (6%)
Query: 180 KQLWLQLKKEEPHL-LSNFEDFLTRIISQLQEAHEEKNELECALKR---------KIAAY 229
K L+ +E H+ ++ + R Q EA + E E L+R ++
Sbjct: 1725 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784
Query: 230 DEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEG 289
EE+ + + + +KE+ + R +A Q + Q+ L EQELE+ Q +
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA-EQELEKQRQLAEGTAQ 1843
Query: 290 QCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEM 349
Q A + +AE + + Q L EL R E A Q+ + L+ E K+ E E+
Sbjct: 1844 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1903
Score = 43.9 bits (102), Expect = 3e-04
Identities = 65/297 (21%), Positives = 127/297 (42%), Gaps = 24/297 (8%)
Query: 126 EDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQ 185
E+A A E K +ED + E + +G L+ E+++ +
Sbjct: 1938 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1997
Query: 186 LKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH----LYEEME 241
+ E L+ E F R + ++A + K ++E L + A D E++ + + +
Sbjct: 1998 AENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 2055
Query: 242 QQIKSEKEQFLLKDT-ERFQARSQEL-----------EQKLLCKEQ-ELEQLTQKQKRLE 288
Q+ + E+E LK + E+ A EL E L KEQ ELE Q+Q E
Sbjct: 2056 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2115
Query: 289 GQCTALHHDKHETKAENTKLKLTNQELA--RELERTSWELQDAQQQLESLQQEACKLHQE 346
+ ++ K+ + + Q A E+ER ++++A++ E +QE+ + Q
Sbjct: 2116 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2175
Query: 347 KEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQ-KNKAAKANTAASRA 402
+ + ++ ++ A ++Q + +E + L+ E+ + Q + +A A AA A
Sbjct: 2176 AQEAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2230
Score = 42.7 bits (99), Expect = 7e-04
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 14/163 (8%)
Query: 221 ALKRKIAAYDEEIQHLYEEMEQQ------IKSEKEQFLLKDTERFQARSQELEQKLLCKE 274
A K K+ + E + Y ++ + S+ +F+ + R + + EQ+ +
Sbjct: 1437 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ---RA 1493
Query: 275 QELEQLTQKQKRLEGQCT-ALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQL 333
+E E+L + + LE Q A H + + +AE +L Q + E+ R DAQQQ
Sbjct: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL-QQRMQEEVVRREEAAVDAQQQK 1552
Query: 334 ESLQQEACKLHQEKEMEVY---RVTESLQREKAGLLKQLDFLR 373
S+Q+E +L Q E E+ R E+ +R + + +++ +R
Sbjct: 1553 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595
Score = 40.4 bits (93), Expect = 0.003
Identities = 59/262 (22%), Positives = 117/262 (44%), Gaps = 33/262 (12%)
Query: 156 EEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEK 215
EEA+ R + A++ E+ + W E L E+ + EA ++K
Sbjct: 1745 EEAE-RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803
Query: 216 NELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE-------QFLLKDTERFQARSQELEQ 268
E E +R+ A ++ ++ E EQ+++ +++ Q L + E + R+ E EQ
Sbjct: 1804 EEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-ETEQ 1861
Query: 269 KLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL----ARELERTSW 324
EQ+ + L ++ RL+ + A + E +AE K++ + L AR E +
Sbjct: 1862 G----EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917
Query: 325 ELQDAQQQLES-------LQQEACKLH---QEKEMEVYRVTESLQREKAG----LLKQLD 370
+ ++Q+LE+ L +EA +L +E + + E R++A L ++L
Sbjct: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977
Query: 371 FLRERNKHLRDERDICFQKNKA 392
+ E + L+ E +I ++ +A
Sbjct: 1978 AIGEATR-LKTEAEIALKEKEA 1998
Score = 36.2 bits (82), Expect = 0.064
Identities = 61/259 (23%), Positives = 115/259 (44%), Gaps = 38/259 (14%)
Query: 125 QEDAGEQVAQRHEEKVYLSRG----DEDLGDMGEDEEAQFRMLMDRLGA--QKVLEDESD 178
Q+ E+V +R E V + E+L + + EA+ + + A + L E +
Sbjct: 1531 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1590
Query: 179 VKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYE 238
++ + LQL+ E E L + ++ +EA +K + + +R +E Q +
Sbjct: 1591 IRVVRLQLEATERQR-GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1649
Query: 239 ---EMEQQIKSEKE-----QFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEG- 289
E+ ++K+E E Q L+ E + +++E E++L ++ E+E+ Q Q LE
Sbjct: 1650 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL--RQAEVERARQVQVALETA 1707
Query: 290 --QCTALHHDKHETKAENT-KLKLTNQE-------LARELERTSWEL-------QDAQQQ 332
A K + AE T +L+ + QE L E ER + + ++A+++
Sbjct: 1708 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1767
Query: 333 LESLQ---QEACKLHQEKE 348
LE Q EA +L + E
Sbjct: 1768 LERWQLKANEALRLRLQAE 1786
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 60.8 bits (146), Expect = 2e-09
Identities = 70/294 (23%), Positives = 141/294 (47%), Gaps = 26/294 (8%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
+E A EQ + E+K E + +E F+ ++ Q+ LE ++ ++L L
Sbjct: 2314 KELAQEQARRLQEDK-------EQMAQQLAEETQGFQRTLEA-ERQRQLEMSAEAERLKL 2365
Query: 185 QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDE-EIQ-----HLYE 238
++ E + E+ R Q +E E+ + E A + K+ EIQ H E
Sbjct: 2366 RVA-EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2424
Query: 239 EMEQ---QIKSEKEQFLLKDTERFQARSQELE----QKLLCKEQELEQ--LTQKQKRLEG 289
+ + +++ EKE+ L ++ + Q +S+E++ ++LL + Q L+Q L++K L+
Sbjct: 2425 RLREAIAELEREKEK-LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2483
Query: 290 QCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEM 349
+ + +K + + Q+L E +R +++ +Q+L + +EA + E E
Sbjct: 2484 E-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2542
Query: 350 EVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRAS 403
V R E LQ+ + +Q + L E N+ LR++ + ++++AA A++ AS
Sbjct: 2543 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2596
Score = 60.1 bits (144), Expect = 4e-09
Identities = 71/342 (20%), Positives = 150/342 (43%), Gaps = 22/342 (6%)
Query: 124 SQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQ-- 181
+Q A + ++ E+ R + + + + A M + A++ L ++ V+Q
Sbjct: 2107 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2166
Query: 182 --LWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEE 239
L LQL+ E H + ++ L R+ ++ EA +++++E L + EE+ L
Sbjct: 2167 TTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF-SVRVQMEELSKL--- 2221
Query: 240 MEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKH 299
+ +I++E +L+D + Q QE +K+ +E +L+ + D
Sbjct: 2222 -KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2280
Query: 300 ETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQ 359
+ +A K+ + +E R E + QQQ E Q++A +L ++KE ++ + L
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE----QMAQQLA 2336
Query: 360 REKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWK----KRSGSVIGKY 415
E G + L+ R+R + E + K + A+ + A +RA ++ IG+
Sbjct: 2337 EETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2394
Query: 416 VDSRGILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKKICKAE 457
+ + + ++ + TL+ Q Q+ D + + I + E
Sbjct: 2395 LHRTELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELE 2434
Score = 50.1 bits (118), Expect = 4e-06
Identities = 94/421 (22%), Positives = 164/421 (38%), Gaps = 89/421 (21%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGD----EDLGDMGEDEEAQFRMLMDRLGAQKVLED 175
Q +E A + A E L + E + ED Q R + + + A K +
Sbjct: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1913
Query: 176 ESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH 235
++ + L+L E + SN ED L +E+ ELE A +R++AA +E +
Sbjct: 1914 KAAAGKAELEL--ELGRIRSNAEDTLRS---------KEQAELEAARQRQLAAEEERRRR 1962
Query: 236 LYEEMEQQIKSEKEQFL------LKDTERFQAR---------------------SQELEQ 268
EE Q+ + +E+ L++ ER +A+ +QE Q
Sbjct: 1963 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2022
Query: 269 KLLC------------KEQELEQLTQKQK----RLEGQCTALHHDKHETKAENTKLKLTN 312
K L KEQEL+Q Q+++ +L G+ A E + + +
Sbjct: 2023 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2082
Query: 313 QELARELERTSWELQDAQQQLES---LQQEACKLHQEKEMEVYRVTESLQ---------- 359
+ R++E Q A++Q ++ Q A KL +E E E R ++ Q
Sbjct: 2083 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2142
Query: 360 --------------REKAGLLKQLDFLR---ERNKHLRDERDICFQKNKAAKANTAASRA 402
R+KA + ++L LR E H ++ D Q+ KA A R+
Sbjct: 2143 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2202
Query: 403 SWKKRSGSVIGKYVDSRGILRRWPQRDRG-IPTLQYQTQRDLEDCKHEMKKICKAEVTLE 461
++ SV + + + R +R I + TQR L++ +MK++ + L
Sbjct: 2203 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2262
Query: 462 M 462
+
Sbjct: 2263 V 2263
Score = 49.7 bits (117), Expect = 6e-06
Identities = 56/296 (18%), Positives = 131/296 (44%), Gaps = 18/296 (6%)
Query: 165 DRLGAQKVLEDESDVKQLWLQLKKE----EPHLLSNF--EDFLTRIISQLQEAHEEKNEL 218
+RL Q+ E+ + ++ L+K+ E H + E + ++QE + E
Sbjct: 1326 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1385
Query: 219 ECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELE 278
+++ + EE+Q L + E +I+++ Q + R + +E+++ +LE
Sbjct: 1386 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR-----IEEEIRVVRLQLE 1440
Query: 279 QLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQ 338
+++ EG+ AL E +A+ + + + L R+++ S + A+ +L S +
Sbjct: 1441 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1500
Query: 339 EACKLHQEKEMEVYRVTE-SLQREKA-GLLKQLDFLRERNKHLRDERDICFQKNKAAKAN 396
+ +EK+ + + E LQ E+A L+Q + R R + E ++A+A
Sbjct: 1501 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-----TAQRSAEAE 1555
Query: 397 TAASRASWKKRSGSVIGKYVDSRGILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKK 452
+ RAS+ +++ + + + + + Q + +R E+ + E+++
Sbjct: 1556 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/180 (24%), Positives = 75/180 (41%), Gaps = 11/180 (6%)
Query: 180 KQLWLQLKKEEPHL-LSNFEDFLTRIISQLQEAHEEKNELECALKR---------KIAAY 229
K L+ +E H+ ++ + R Q EA + E E L+R ++
Sbjct: 1566 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1625
Query: 230 DEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEG 289
EE+ + + + +KE+ + R +A Q + Q+ L EQELE+ Q +
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA-EQELEKQRQLAEGTAQ 1684
Query: 290 QCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEM 349
Q A + +AE + + Q L EL R E A Q+ + L+ E K+ E E+
Sbjct: 1685 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1744
Score = 43.9 bits (102), Expect = 3e-04
Identities = 65/297 (21%), Positives = 127/297 (42%), Gaps = 24/297 (8%)
Query: 126 EDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQ 185
E+A A E K +ED + E + +G L+ E+++ +
Sbjct: 1779 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1838
Query: 186 LKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH----LYEEME 241
+ E L+ E F R + ++A + K ++E L + A D E++ + + +
Sbjct: 1839 AENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1896
Query: 242 QQIKSEKEQFLLKDT-ERFQARSQEL-----------EQKLLCKEQ-ELEQLTQKQKRLE 288
Q+ + E+E LK + E+ A EL E L KEQ ELE Q+Q E
Sbjct: 1897 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1956
Query: 289 GQCTALHHDKHETKAENTKLKLTNQELA--RELERTSWELQDAQQQLESLQQEACKLHQE 346
+ ++ K+ + + Q A E+ER ++++A++ E +QE+ + Q
Sbjct: 1957 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2016
Query: 347 KEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQ-KNKAAKANTAASRA 402
+ + ++ ++ A ++Q + +E + L+ E+ + Q + +A A AA A
Sbjct: 2017 AQEAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2071
Score = 42.7 bits (99), Expect = 7e-04
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 14/163 (8%)
Query: 221 ALKRKIAAYDEEIQHLYEEMEQQ------IKSEKEQFLLKDTERFQARSQELEQKLLCKE 274
A K K+ + E + Y ++ + S+ +F+ + R + + EQ+ +
Sbjct: 1278 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ---RA 1334
Query: 275 QELEQLTQKQKRLEGQCT-ALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQL 333
+E E+L + + LE Q A H + + +AE +L Q + E+ R DAQQQ
Sbjct: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL-QQRMQEEVVRREEAAVDAQQQK 1393
Query: 334 ESLQQEACKLHQEKEMEVY---RVTESLQREKAGLLKQLDFLR 373
S+Q+E +L Q E E+ R E+ +R + + +++ +R
Sbjct: 1394 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436
Score = 40.4 bits (93), Expect = 0.003
Identities = 59/262 (22%), Positives = 117/262 (44%), Gaps = 33/262 (12%)
Query: 156 EEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEK 215
EEA+ R + A++ E+ + W E L E+ + EA ++K
Sbjct: 1586 EEAE-RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1644
Query: 216 NELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE-------QFLLKDTERFQARSQELEQ 268
E E +R+ A ++ ++ E EQ+++ +++ Q L + E + R+ E EQ
Sbjct: 1645 EEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-ETEQ 1702
Query: 269 KLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL----ARELERTSW 324
EQ+ + L ++ RL+ + A + E +AE K++ + L AR E +
Sbjct: 1703 G----EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1758
Query: 325 ELQDAQQQLES-------LQQEACKLH---QEKEMEVYRVTESLQREKAG----LLKQLD 370
+ ++Q+LE+ L +EA +L +E + + E R++A L ++L
Sbjct: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818
Query: 371 FLRERNKHLRDERDICFQKNKA 392
+ E + L+ E +I ++ +A
Sbjct: 1819 AIGEATR-LKTEAEIALKEKEA 1839
Score = 36.2 bits (82), Expect = 0.064
Identities = 61/259 (23%), Positives = 115/259 (44%), Gaps = 38/259 (14%)
Query: 125 QEDAGEQVAQRHEEKVYLSRG----DEDLGDMGEDEEAQFRMLMDRLGA--QKVLEDESD 178
Q+ E+V +R E V + E+L + + EA+ + + A + L E +
Sbjct: 1372 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1431
Query: 179 VKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYE 238
++ + LQL+ E E L + ++ +EA +K + + +R +E Q +
Sbjct: 1432 IRVVRLQLEATERQR-GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1490
Query: 239 ---EMEQQIKSEKE-----QFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEG- 289
E+ ++K+E E Q L+ E + +++E E++L ++ E+E+ Q Q LE
Sbjct: 1491 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL--RQAEVERARQVQVALETA 1548
Query: 290 --QCTALHHDKHETKAENT-KLKLTNQE-------LARELERTSWEL-------QDAQQQ 332
A K + AE T +L+ + QE L E ER + + ++A+++
Sbjct: 1549 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1608
Query: 333 LESLQ---QEACKLHQEKE 348
LE Q EA +L + E
Sbjct: 1609 LERWQLKANEALRLRLQAE 1627
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 60.8 bits (146), Expect = 2e-09
Identities = 70/294 (23%), Positives = 141/294 (47%), Gaps = 26/294 (8%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
+E A EQ + E+K E + +E F+ ++ Q+ LE ++ ++L L
Sbjct: 2322 KELAQEQARRLQEDK-------EQMAQQLAEETQGFQRTLEA-ERQRQLEMSAEAERLKL 2373
Query: 185 QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDE-EIQ-----HLYE 238
++ E + E+ R Q +E E+ + E A + K+ EIQ H E
Sbjct: 2374 RVA-EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2432
Query: 239 EMEQ---QIKSEKEQFLLKDTERFQARSQELE----QKLLCKEQELEQ--LTQKQKRLEG 289
+ + +++ EKE+ L ++ + Q +S+E++ ++LL + Q L+Q L++K L+
Sbjct: 2433 RLREAIAELEREKEK-LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2491
Query: 290 QCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEM 349
+ + +K + + Q+L E +R +++ +Q+L + +EA + E E
Sbjct: 2492 E-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2550
Query: 350 EVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRAS 403
V R E LQ+ + +Q + L E N+ LR++ + ++++AA A++ AS
Sbjct: 2551 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2604
Score = 60.1 bits (144), Expect = 4e-09
Identities = 71/342 (20%), Positives = 150/342 (43%), Gaps = 22/342 (6%)
Query: 124 SQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQ-- 181
+Q A + ++ E+ R + + + + A M + A++ L ++ V+Q
Sbjct: 2115 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2174
Query: 182 --LWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEE 239
L LQL+ E H + ++ L R+ ++ EA +++++E L + EE+ L
Sbjct: 2175 TTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF-SVRVQMEELSKL--- 2229
Query: 240 MEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKH 299
+ +I++E +L+D + Q QE +K+ +E +L+ + D
Sbjct: 2230 -KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2288
Query: 300 ETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQ 359
+ +A K+ + +E R E + QQQ E Q++A +L ++KE ++ + L
Sbjct: 2289 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE----QMAQQLA 2344
Query: 360 REKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWK----KRSGSVIGKY 415
E G + L+ R+R + E + K + A+ + A +RA ++ IG+
Sbjct: 2345 EETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2402
Query: 416 VDSRGILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKKICKAE 457
+ + + ++ + TL+ Q Q+ D + + I + E
Sbjct: 2403 LHRTELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELE 2442
Score = 50.1 bits (118), Expect = 4e-06
Identities = 94/421 (22%), Positives = 164/421 (38%), Gaps = 89/421 (21%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGD----EDLGDMGEDEEAQFRMLMDRLGAQKVLED 175
Q +E A + A E L + E + ED Q R + + + A K +
Sbjct: 1862 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1921
Query: 176 ESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH 235
++ + L+L E + SN ED L +E+ ELE A +R++AA +E +
Sbjct: 1922 KAAAGKAELEL--ELGRIRSNAEDTLRS---------KEQAELEAARQRQLAAEEERRRR 1970
Query: 236 LYEEMEQQIKSEKEQFL------LKDTERFQAR---------------------SQELEQ 268
EE Q+ + +E+ L++ ER +A+ +QE Q
Sbjct: 1971 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2030
Query: 269 KLLC------------KEQELEQLTQKQK----RLEGQCTALHHDKHETKAENTKLKLTN 312
K L KEQEL+Q Q+++ +L G+ A E + + +
Sbjct: 2031 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2090
Query: 313 QELARELERTSWELQDAQQQLES---LQQEACKLHQEKEMEVYRVTESLQ---------- 359
+ R++E Q A++Q ++ Q A KL +E E E R ++ Q
Sbjct: 2091 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2150
Query: 360 --------------REKAGLLKQLDFLR---ERNKHLRDERDICFQKNKAAKANTAASRA 402
R+KA + ++L LR E H ++ D Q+ KA A R+
Sbjct: 2151 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2210
Query: 403 SWKKRSGSVIGKYVDSRGILRRWPQRDRG-IPTLQYQTQRDLEDCKHEMKKICKAEVTLE 461
++ SV + + + R +R I + TQR L++ +MK++ + L
Sbjct: 2211 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2270
Query: 462 M 462
+
Sbjct: 2271 V 2271
Score = 49.7 bits (117), Expect = 6e-06
Identities = 56/296 (18%), Positives = 131/296 (44%), Gaps = 18/296 (6%)
Query: 165 DRLGAQKVLEDESDVKQLWLQLKKE----EPHLLSNF--EDFLTRIISQLQEAHEEKNEL 218
+RL Q+ E+ + ++ L+K+ E H + E + ++QE + E
Sbjct: 1334 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1393
Query: 219 ECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELE 278
+++ + EE+Q L + E +I+++ Q + R + +E+++ +LE
Sbjct: 1394 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR-----IEEEIRVVRLQLE 1448
Query: 279 QLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQ 338
+++ EG+ AL E +A+ + + + L R+++ S + A+ +L S +
Sbjct: 1449 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1508
Query: 339 EACKLHQEKEMEVYRVTE-SLQREKA-GLLKQLDFLRERNKHLRDERDICFQKNKAAKAN 396
+ +EK+ + + E LQ E+A L+Q + R R + E ++A+A
Sbjct: 1509 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-----TAQRSAEAE 1563
Query: 397 TAASRASWKKRSGSVIGKYVDSRGILRRWPQRDRGIPTLQYQTQRDLEDCKHEMKK 452
+ RAS+ +++ + + + + + Q + +R E+ + E+++
Sbjct: 1564 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/180 (24%), Positives = 75/180 (41%), Gaps = 11/180 (6%)
Query: 180 KQLWLQLKKEEPHL-LSNFEDFLTRIISQLQEAHEEKNELECALKR---------KIAAY 229
K L+ +E H+ ++ + R Q EA + E E L+R ++
Sbjct: 1574 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1633
Query: 230 DEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEG 289
EE+ + + + +KE+ + R +A Q + Q+ L EQELE+ Q +
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA-EQELEKQRQLAEGTAQ 1692
Query: 290 QCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEM 349
Q A + +AE + + Q L EL R E A Q+ + L+ E K+ E E+
Sbjct: 1693 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1752
Score = 43.9 bits (102), Expect = 3e-04
Identities = 65/297 (21%), Positives = 127/297 (42%), Gaps = 24/297 (8%)
Query: 126 EDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQ 185
E+A A E K +ED + E + +G L+ E+++ +
Sbjct: 1787 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1846
Query: 186 LKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH----LYEEME 241
+ E L+ E F R + ++A + K ++E L + A D E++ + + +
Sbjct: 1847 AENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1904
Query: 242 QQIKSEKEQFLLKDT-ERFQARSQEL-----------EQKLLCKEQ-ELEQLTQKQKRLE 288
Q+ + E+E LK + E+ A EL E L KEQ ELE Q+Q E
Sbjct: 1905 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1964
Query: 289 GQCTALHHDKHETKAENTKLKLTNQELA--RELERTSWELQDAQQQLESLQQEACKLHQE 346
+ ++ K+ + + Q A E+ER ++++A++ E +QE+ + Q
Sbjct: 1965 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2024
Query: 347 KEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQ-KNKAAKANTAASRA 402
+ + ++ ++ A ++Q + +E + L+ E+ + Q + +A A AA A
Sbjct: 2025 AQEAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2079
Score = 42.7 bits (99), Expect = 7e-04
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 14/163 (8%)
Query: 221 ALKRKIAAYDEEIQHLYEEMEQQ------IKSEKEQFLLKDTERFQARSQELEQKLLCKE 274
A K K+ + E + Y ++ + S+ +F+ + R + + EQ+ +
Sbjct: 1286 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ---RA 1342
Query: 275 QELEQLTQKQKRLEGQCT-ALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQL 333
+E E+L + + LE Q A H + + +AE +L Q + E+ R DAQQQ
Sbjct: 1343 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL-QQRMQEEVVRREEAAVDAQQQK 1401
Query: 334 ESLQQEACKLHQEKEMEVY---RVTESLQREKAGLLKQLDFLR 373
S+Q+E +L Q E E+ R E+ +R + + +++ +R
Sbjct: 1402 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1444
Score = 40.4 bits (93), Expect = 0.003
Identities = 59/262 (22%), Positives = 117/262 (44%), Gaps = 33/262 (12%)
Query: 156 EEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEK 215
EEA+ R + A++ E+ + W E L E+ + EA ++K
Sbjct: 1594 EEAE-RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1652
Query: 216 NELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE-------QFLLKDTERFQARSQELEQ 268
E E +R+ A ++ ++ E EQ+++ +++ Q L + E + R+ E EQ
Sbjct: 1653 EEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-ETEQ 1710
Query: 269 KLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL----ARELERTSW 324
EQ+ + L ++ RL+ + A + E +AE K++ + L AR E +
Sbjct: 1711 G----EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1766
Query: 325 ELQDAQQQLES-------LQQEACKLH---QEKEMEVYRVTESLQREKAG----LLKQLD 370
+ ++Q+LE+ L +EA +L +E + + E R++A L ++L
Sbjct: 1767 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1826
Query: 371 FLRERNKHLRDERDICFQKNKA 392
+ E + L+ E +I ++ +A
Sbjct: 1827 AIGEATR-LKTEAEIALKEKEA 1847
Score = 36.2 bits (82), Expect = 0.064
Identities = 61/259 (23%), Positives = 115/259 (44%), Gaps = 38/259 (14%)
Query: 125 QEDAGEQVAQRHEEKVYLSRG----DEDLGDMGEDEEAQFRMLMDRLGA--QKVLEDESD 178
Q+ E+V +R E V + E+L + + EA+ + + A + L E +
Sbjct: 1380 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1439
Query: 179 VKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYE 238
++ + LQL+ E E L + ++ +EA +K + + +R +E Q +
Sbjct: 1440 IRVVRLQLEATERQR-GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1498
Query: 239 ---EMEQQIKSEKE-----QFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEG- 289
E+ ++K+E E Q L+ E + +++E E++L ++ E+E+ Q Q LE
Sbjct: 1499 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL--RQAEVERARQVQVALETA 1556
Query: 290 --QCTALHHDKHETKAENT-KLKLTNQE-------LARELERTSWEL-------QDAQQQ 332
A K + AE T +L+ + QE L E ER + + ++A+++
Sbjct: 1557 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1616
Query: 333 LESLQ---QEACKLHQEKE 348
LE Q EA +L + E
Sbjct: 1617 LERWQLKANEALRLRLQAE 1635
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,839,759
Number of Sequences: 37866
Number of extensions: 876270
Number of successful extensions: 11414
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 389
Number of HSP's successfully gapped in prelim test: 1030
Number of HSP's that attempted gapping in prelim test: 4700
Number of HSP's gapped (non-prelim): 4161
length of query: 462
length of database: 18,247,518
effective HSP length: 106
effective length of query: 356
effective length of database: 14,233,722
effective search space: 5067205032
effective search space used: 5067205032
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.