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Search of human proteins with 222352143
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
(917 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 1835 0.0
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 612 e-175
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 567 e-161
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 182 2e-45
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 139 9e-33
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 122 2e-27
gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 118 3e-26
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 117 5e-26
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 115 1e-25
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso... 114 3e-25
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso... 114 3e-25
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 110 5e-24
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 109 1e-23
gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 105 1e-22
gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 105 1e-22
gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 105 1e-22
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 100 6e-21
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 100 6e-21
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 93 1e-18
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 92 2e-18
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 89 1e-17
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 89 1e-17
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 86 1e-16
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 85 4e-16
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 84 6e-16
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 82 2e-15
gi|38570103 TBC1 domain family, member 8B (with GRAM domain) iso... 80 7e-15
gi|226693407 TBC1 domain family, member 3H [Homo sapiens] 78 3e-14
gi|157502205 TBC1 domain family, member 3G [Homo sapiens] 78 3e-14
gi|183583565 TBC1 domain family, member 3 [Homo sapiens] 77 7e-14
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 1835 bits (4752), Expect = 0.0
Identities = 917/917 (100%), Positives = 917/917 (100%)
Query: 1 MEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGP 60
MEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGP
Sbjct: 1 MEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGP 60
Query: 61 IRGWKSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVI 120
IRGWKSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVI
Sbjct: 61 IRGWKSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVI 120
Query: 121 TLKAATKQAMLYWLQQLQMKRWEFHNSPPAPPATPDAALAGNGPVLHLELGQEEAELEEF 180
TLKAATKQAMLYWLQQLQMKRWEFHNSPPAPPATPDAALAGNGPVLHLELGQEEAELEEF
Sbjct: 121 TLKAATKQAMLYWLQQLQMKRWEFHNSPPAPPATPDAALAGNGPVLHLELGQEEAELEEF 180
Query: 181 LCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDS 240
LCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDS
Sbjct: 181 LCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDS 240
Query: 241 PQSGEPQREEQPLASDASTPGREPEDSPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITR 300
PQSGEPQREEQPLASDASTPGREPEDSPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITR
Sbjct: 241 PQSGEPQREEQPLASDASTPGREPEDSPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITR 300
Query: 301 NRTAQEKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKRASSAYLAAAEDKDRLE 360
NRTAQEKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKRASSAYLAAAEDKDRLE
Sbjct: 301 NRTAQEKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKRASSAYLAAAEDKDRLE 360
Query: 361 LVRHKVRQIAELGRRVEALEQERESLAHTASLREQQVQELQQHVQLLMDKNHAKQQVICK 420
LVRHKVRQIAELGRRVEALEQERESLAHTASLREQQVQELQQHVQLLMDKNHAKQQVICK
Sbjct: 361 LVRHKVRQIAELGRRVEALEQERESLAHTASLREQQVQELQQHVQLLMDKNHAKQQVICK 420
Query: 421 LSEKVTQDFTHPPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLNSEIHQVTK 480
LSEKVTQDFTHPPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLNSEIHQVTK
Sbjct: 421 LSEKVTQDFTHPPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLNSEIHQVTK 480
Query: 481 IWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEALGDEASECSELLRQLVQEAL 540
IWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEALGDEASECSELLRQLVQEAL
Sbjct: 481 IWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEALGDEASECSELLRQLVQEAL 540
Query: 541 QWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDR 600
QWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDR
Sbjct: 541 QWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDR 600
Query: 601 PLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQ 660
PLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQ
Sbjct: 601 PLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQ 660
Query: 661 AREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAA 720
AREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAA
Sbjct: 661 AREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAA 720
Query: 721 IALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQ 780
IALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQ
Sbjct: 721 IALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQ 780
Query: 781 HHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKYNEKEILRLQNGLEIYQYLRF 840
HHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKYNEKEILRLQNGLEIYQYLRF
Sbjct: 781 HHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKYNEKEILRLQNGLEIYQYLRF 840
Query: 841 FTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKAEYLERRASRR 900
FTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKAEYLERRASRR
Sbjct: 841 FTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKAEYLERRASRR 900
Query: 901 RAVSEGCASEDEVEGEA 917
RAVSEGCASEDEVEGEA
Sbjct: 901 RAVSEGCASEDEVEGEA 917
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 612 bits (1577), Expect = e-175
Identities = 381/971 (39%), Positives = 559/971 (57%), Gaps = 100/971 (10%)
Query: 1 MEGAGENAPESSSSAPGSEE-SARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKG 59
M GAG A E G+ + +A +P P E P +LCGYL K GKG
Sbjct: 1 MPGAGARAEEGGGGGEGAAQGAAAEPGAGPARE------------PARLCGYLQKLSGKG 48
Query: 60 PIRGWKSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKAD---AEEGI-----F 111
P+RG++SRWF +D R+C LYY ++ QDA PL +D++ A F + AE G F
Sbjct: 49 PLRGYRSRWFVFDARRCYLYYFKSPQDALPLGHLDIADACFSYQGPDEAAEPGTEPPAHF 108
Query: 112 EIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNS----------PPAPPATPDAALAG 161
++ + V LKA +Q M YWLQ+LQ KRWE+ NS P P P +A
Sbjct: 109 QVHSAGAVTVLKAPNRQLMTYWLQELQQKRWEYCNSLDMVKWDSRTSPTPGDFPKGLVAR 168
Query: 162 NGPVLHLELGQEEAELEEFLCPVKTPPG-LVGVAAALQPFPALQN----ISLKHLGTEIQ 216
+ L AE + V+T PG LVG AA QP P N SLK G E++
Sbjct: 169 DNTDLIYPHPNASAEKARNVLAVETVPGELVGEQAANQPAPGHPNSINFYSLKQWGNELK 228
Query: 217 NTMHNIRGNKQAQGTGH-----------------EPPGEDSPQS--GEPQREEQPLASDA 257
N+M + R G GH +P +D +S E +++ P +
Sbjct: 229 NSMSSFR-----PGRGHNDSRRTVFYTNEEWELLDPTPKDLEESIVQEEKKKLTPEGNKG 283
Query: 258 STPGREPED---SPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTA---------Q 305
T P D +P +P I + K R ++ P SEG + + + Q
Sbjct: 284 VTGSGFPFDFGRNPYKGKRPLKDIIGSYK-NRHSSGDPS-SEGTSGSGSVSIRKPASEMQ 341
Query: 306 EKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKRASSAYLAAAEDKDRLELVRHK 365
+V + ++++ L K+L SQKELV++L + + ++Q +K +S+ L KD LEL+ K
Sbjct: 342 LQVQSQQEELEQLKKDLSSQKELVRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQK 401
Query: 366 VRQIAELGRRVEALEQERESLAHTASLREQQVQELQQHVQLLMDKNHAKQQVICKLSEKV 425
QI L ++E E+ESL + +V EL + + +LM+ AK +VI KLSE
Sbjct: 402 DDQILGLTSQLERFSLEKESLQQEVRTLKSKVGELNEQLGMLMETIQAKDEVIIKLSEG- 460
Query: 426 TQDFTHPPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLNSEIHQVTKIWRKV 485
+ PP +P P Q +++ LKD+++ Y+TQN FLN EI +++ + R
Sbjct: 461 -EGNGPPPTVAPSSPSVV--PVARDQLELDRLKDNLQGYKTQNKFLNKEILELSALRRNA 517
Query: 486 AEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEAL-GDEASECSELLRQLVQEALQWEA 544
+E+ L+ K + L+A+ CQ+ESKYL L+ ++ + ++ E++ QL+++ALQ E+
Sbjct: 518 ERRERDLMAKYSSLEAKLCQIESKYLILLQEMKTPVCSEDQGPTREVIAQLLEDALQVES 577
Query: 545 GEASSDS-IELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLR 603
E + ++ +S+YD YGF TVP+ + E+ KL+AK++AL+ ++ +L + V ++
Sbjct: 578 QEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEE-KLVAKVRALDLKTLYLTENQEVSTGVK 636
Query: 604 -ERWAALG---DLVPSAELKQLLRAGVPREHRPRVWRWLV--HLRVQHLHT-PGCYQELL 656
E + A +++ S ELK L+RAG+P EHR +VW+W V H R +T PG +Q LL
Sbjct: 637 WENYFASTVNREMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLL 696
Query: 657 SRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLN 716
+ +++PA++QIELDL RT PNNKH++CPTS KLR VLLAFSW+NP IGYCQGLN
Sbjct: 697 QKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLN 756
Query: 717 RLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMA 776
RL A+ALL LE+E+ AFWCLV IVE MP DYY TL SQVDQRV +DL+SEKLPRL
Sbjct: 757 RLVAVALLYLEQED-AFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHG 815
Query: 777 HLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGT-----------KYNEKEI 825
H Q+ VD +L+TFNWFLVVF DS++S+IL ++WD+FLYEG KY E+EI
Sbjct: 816 HFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEI 875
Query: 826 LRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELREL 885
L+LQ+ + I++YLR+FT+TI ++RKL++I+F D+NPF ++Q+R R H E++ EL EL
Sbjct: 876 LKLQDSMSIFKYLRYFTRTILDARKLISISFGDLNPFPLRQIRNRRAYHLEKVRLELTEL 935
Query: 886 EQLKAEYLERR 896
E ++ ++L R
Sbjct: 936 EAIREDFLRER 946
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 567 bits (1462), Expect = e-161
Identities = 361/924 (39%), Positives = 526/924 (56%), Gaps = 100/924 (10%)
Query: 1 MEGAGENAPESSSSAPGSEE-SARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKG 59
M GAG A E G+ + +A +P P E P +LCGYL K GKG
Sbjct: 1 MPGAGARAEEGGGGGEGAAQGAAAEPGAGPARE------------PARLCGYLQKLSGKG 48
Query: 60 PIRGWKSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKAD---AEEGI-----F 111
P+RG++SRWF +D R+C LYY ++ QDA PL +D++ A F + AE G F
Sbjct: 49 PLRGYRSRWFVFDARRCYLYYFKSPQDALPLGHLDIADACFSYQGPDEAAEPGTEPPAHF 108
Query: 112 EIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNS----------PPAPPATPDAALAG 161
++ + V LKA +Q M YWLQ+LQ KRWE+ NS P P P +A
Sbjct: 109 QVHSAGAVTVLKAPNRQLMTYWLQELQQKRWEYCNSLDMVKWDSRTSPTPGDFPKGLVAR 168
Query: 162 NGPVLHLELGQEEAELEEFLCPVKTPPG-LVGVAAALQPFPALQN----ISLKHLGTEIQ 216
+ L AE + V+T PG LVG AA QP P N SLK G E++
Sbjct: 169 DNTDLIYPHPNASAEKARNVLAVETVPGELVGEQAANQPAPGHPNSINFYSLKQWGNELK 228
Query: 217 NTMHNIRGNKQAQGTGH-----------------EPPGEDSPQS--GEPQREEQPLASDA 257
N+M + R G GH +P +D +S E +++ P +
Sbjct: 229 NSMSSFR-----PGRGHNDSRRTVFYTNEEWELLDPTPKDLEESIVQEEKKKLTPEGNKG 283
Query: 258 STPGREPED---SPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTA---------Q 305
T P D +P +P I + K R ++ P SEG + + + Q
Sbjct: 284 VTGSGFPFDFGRNPYKGKRPLKDIIGSYK-NRHSSGDPS-SEGTSGSGSVSIRKPASEMQ 341
Query: 306 EKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKRASSAYLAAAEDKDRLELVRHK 365
+V + ++++ L K+L SQKELV++L + + ++Q +K +S+ L KD LEL+ K
Sbjct: 342 LQVQSQQEELEQLKKDLSSQKELVRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQK 401
Query: 366 VRQIAELGRRVEALEQERESLAHTASLREQQVQELQQHVQLLMDKNHAKQQVICKLSEKV 425
QI L ++E E+ESL + +V EL + + +LM+ AK +VI KLSE
Sbjct: 402 DDQILGLTSQLERFSLEKESLQQEVRTLKSKVGELNEQLGMLMETIQAKDEVIIKLSEG- 460
Query: 426 TQDFTHPPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLNSEIHQVTKIWRKV 485
+ PP +P P Q +++ LKD+++ Y+TQN FLN EI +++ + R
Sbjct: 461 -EGNGPPPTVAPSSPSVV--PVARDQLELDRLKDNLQGYKTQNKFLNKEILELSALRRNA 517
Query: 486 AEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEAL-GDEASECSELLRQLVQEALQWEA 544
+E+ L+ K + L+A+ CQ+ESKYL L+ ++ + ++ E++ QL+++ALQ E+
Sbjct: 518 ERRERDLMAKYSSLEAKLCQIESKYLILLQEMKTPVCSEDQGPTREVIAQLLEDALQVES 577
Query: 545 GEASSDS-IELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLR 603
E + ++ +S+YD YGF TVP+ + E+ KL+AK++AL+ ++ +L + V ++
Sbjct: 578 QEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEE-KLVAKVRALDLKTLYLTENQEVSTGVK 636
Query: 604 -ERWAALG---DLVPSAELKQLLRAGVPREHRPRVWRWLV--HLRVQHLHT-PGCYQELL 656
E + A +++ S ELK L+RAG+P EHR +VW+W V H R +T PG +Q LL
Sbjct: 637 WENYFASTVNREMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLL 696
Query: 657 SRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLN 716
+ +++PA++QIELDL RT PNNKH++CPTS KLR VLLAFSW+NP IGYCQGLN
Sbjct: 697 QKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLN 756
Query: 717 RLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMA 776
RL A+ALL LE+E+ AFWCLV IVE MP DYY TL SQVDQRV +DL+SEKLPRL
Sbjct: 757 RLVAVALLYLEQED-AFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHG 815
Query: 777 HLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGT-----------KYNEKEI 825
H Q+ VD +L+TFNWFLVVF DS++S+IL ++WD+FLYEG KY E+EI
Sbjct: 816 HFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEI 875
Query: 826 LRLQNGLEIYQYLRFFTKTISNSR 849
L+LQ+ + I++YLR+FT+TI ++R
Sbjct: 876 LKLQDSMSIFKYLRYFTRTILDAR 899
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 182 bits (461), Expect = 2e-45
Identities = 131/394 (33%), Positives = 189/394 (47%), Gaps = 55/394 (13%)
Query: 560 YDEYGFLTVPDYEVED-LKLLAKIQALESRSHHLLGLEAVDRPLRERWAA---------L 609
YDE+GF + E LLA +E D P R RW A +
Sbjct: 42 YDEFGFRVYKEEGDEPGSSLLANSPLME------------DAPQRLRWQAHLEFTHNHDV 89
Query: 610 GDLV---------PSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQ 660
GDL S +L+ L+ AG+P RP++W L + ++ Y+E++
Sbjct: 90 GDLTWDKIAVSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSS 149
Query: 661 AREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAA 720
E AA+QIE DL RT P+N F S +LRRVL A +W P IGYCQG +AA
Sbjct: 150 NDETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAA 209
Query: 721 IALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQ 780
LL LEEE+ AFW + AI+E ++PA Y+ TL Q DQRVL+ L+ + LPRL L +
Sbjct: 210 CLLLFLEEED-AFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQE 268
Query: 781 HHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTK-----------YNEKEILRLQ 829
H ++LSL+T +WFL FA + +LLR+WD F YEG++ E+E+++ +
Sbjct: 269 HDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSE 328
Query: 830 NGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAE-------- 881
N I+ L + ++ L+ +A + R H L A+
Sbjct: 329 NSASIFNTLSDIPSQMEDAELLLGVAMRLAGSLTDVAVETQRRKHLAYLIADQGQLLGAG 388
Query: 882 -LRELEQLKAEYLERRASRRRAVSEGCASEDEVE 914
L L Q+ +RR S A+ G ED++E
Sbjct: 389 TLTNLSQVVRRRTQRRKSTITALLFG---EDDLE 419
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 139 bits (351), Expect = 9e-33
Identities = 98/295 (33%), Positives = 144/295 (48%), Gaps = 22/295 (7%)
Query: 605 RWAAL---GDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQA 661
+W+ L G + S +K+ +R GVP EHR RVW L + Q PG Y +LL Q
Sbjct: 45 KWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLL---QG 101
Query: 662 REHPAARQ-IELDLNRTFPNNKHFTCPTSSFPDK-LRRVLLAFSWQNPTIGYCQGLNRLA 719
+P I DLNRTFP+N F T + L VLLA+ N +GYCQG+N +A
Sbjct: 102 ERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIA 161
Query: 720 AIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLG 779
+L+ EE +FW L A+V I+P DYY + + DQ VL +L+ KLP + A +
Sbjct: 162 GYLILITNNEEESFWLLDALVGRILP-DYYSPAMLGLKTDQEVLGELVRAKLPAVGALME 220
Query: 780 QHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGT-----------KYNEKEILRL 828
+ V +L+ WF+ +F D L +LR+WD EG+ K +++ IL
Sbjct: 221 RLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEA 280
Query: 829 QNGLEIYQYLRFFTK--TISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAE 881
+ +I + TK + M F++ M + +LR R RL A+
Sbjct: 281 TSVPDICDKFKQITKGSFVMECHTFMQKIFSEPGSLSMATVAKLRESCRARLLAQ 335
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 122 bits (306), Expect = 2e-27
Identities = 104/313 (33%), Positives = 146/313 (46%), Gaps = 41/313 (13%)
Query: 517 LQEALGDEASECSELLRQLVQEALQWEAGEASSDSIELS---PISKYDEYGFL------T 567
+ +ALG++ + EL Q ++ SDS ELS P + D YGF+
Sbjct: 1 MAQALGEDLVQPPEL---------QDDSSSLGSDS-ELSGPGPYRQADRYGFIGGSSAEP 50
Query: 568 VPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLRERWAALGDLVPSAELKQLLRAGVP 627
P + DL +++ +E SH ++ + R+ ++K R G+P
Sbjct: 51 GPGHPPADLIRQREMKWVEMTSHW-------EKTMSRRYK---------KVKMQCRKGIP 94
Query: 628 REHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQ-IELDLNRTFPNNKHFTC 686
R R W L V ++PG YQEL +A P + I DL+R FP ++ F
Sbjct: 95 SALRARCWPLLCGAHVCQKNSPGTYQEL---AEAPGDPQWMETIGRDLHRQFPLHEMFVS 151
Query: 687 PTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPA 746
P L +VL A++ P GYCQ +AA+ L+ L EE AFWCLV I E +P
Sbjct: 152 PQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEE-AFWCLVQICEVYLPG 210
Query: 747 DYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNIL 806
YY + A ++D V LL LP + HL Q V L WFL +FA SL +
Sbjct: 211 -YYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTV 269
Query: 807 LRVWDAFLYEGTK 819
LRVWDAFL EG +
Sbjct: 270 LRVWDAFLSEGAR 282
>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
Length = 1140
Score = 118 bits (295), Expect = 3e-26
Identities = 70/203 (34%), Positives = 108/203 (53%), Gaps = 5/203 (2%)
Query: 617 ELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNR 676
++++L+ G+P R R+W PG Y L+ + +IE DL+R
Sbjct: 497 KIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVTEEIERDLHR 556
Query: 677 TFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCL 736
+ P + F T LRRVL A++ +NP IGYCQ +N L ++ LL +EEE AFW L
Sbjct: 557 SLPEHPAFQNETGIAA--LRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEEE-AFWLL 613
Query: 737 VAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVV 796
VA+ E ++P DY+ + + +QVDQ V ++L+ LP L H+ L+ V+ +WFL +
Sbjct: 614 VAVCERMLP-DYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSA-LASVSLSWFLTL 671
Query: 797 FADSLISNILLRVWDAFLYEGTK 819
F + + V D F Y+G K
Sbjct: 672 FLSIMPLESAVNVVDCFFYDGIK 694
>gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1120
Score = 117 bits (293), Expect = 5e-26
Identities = 88/313 (28%), Positives = 146/313 (46%), Gaps = 23/313 (7%)
Query: 549 SDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLRERWAA 608
SD+ E+ ++ E E L + Q LE+ + +L + ++ + +A
Sbjct: 412 SDNFEVQSLTSQRECS----KTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAE 467
Query: 609 LG---DLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHP 665
G + + + + L+ G+P R +W P Y E++ + +
Sbjct: 468 CGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNL 527
Query: 666 AARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLV 725
A +IE DL R+ P + F T LRRVL A++++NP IGYCQ +N L ++ LL
Sbjct: 528 ATEEIERDLRRSLPEHPAFQSDTGI--SALRRVLTAYAYRNPKIGYCQAMNILTSVLLLY 585
Query: 726 LEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDL 785
+EEE AFW LVA+ E ++P DY+ + + VDQ V ++L+ + LP+L H+
Sbjct: 586 AKEEE-AFWLLVAVCERMLP-DYFNRRIIGALVDQAVFEELIRDHLPQLTEHM-TDMTFF 642
Query: 786 SLVTFNWFLVVFADSLISNILLRVWDAFLYEGTK-----------YNEKEILRLQNGLEI 834
S V+ +WFL +F L + V D F Y+G K YN ++L ++ E
Sbjct: 643 SSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAEA 702
Query: 835 YQYLRFFTKTISN 847
L F ++N
Sbjct: 703 VTALNRFFDNVTN 715
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 115 bits (289), Expect = 1e-25
Identities = 70/204 (34%), Positives = 112/204 (54%), Gaps = 11/204 (5%)
Query: 619 KQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTF 678
++L+ G+P R +W L + PG Y++L+ + + + A +IE DL+R+
Sbjct: 509 RELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDLHRSL 568
Query: 679 PNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVA 738
P + F LRRVL A++++NP IGYCQ +N + ++ LL +EEE AFW LVA
Sbjct: 569 PEHPAFQNEMGIAA--LRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEE-AFWLLVA 625
Query: 739 IVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRL---MAHLGQHHVDLSLVTFNWFLV 795
+ E ++P DYY + + VDQ V ++L + +P+L M LG +S ++ +WFL
Sbjct: 626 LCERMLP-DYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGV----ISTISLSWFLT 680
Query: 796 VFADSLISNILLRVWDAFLYEGTK 819
+F + + V D F YEG K
Sbjct: 681 LFLSVMPFESAVVVVDCFFYEGIK 704
>gi|45597177 TBC1 domain family, member 9B (with GRAM domain)
isoform b [Homo sapiens]
Length = 1233
Score = 114 bits (286), Expect = 3e-25
Identities = 69/205 (33%), Positives = 111/205 (54%), Gaps = 5/205 (2%)
Query: 615 SAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDL 674
+A+ + L+ G+P R +W + + PG Y EL+ + + A +IE DL
Sbjct: 498 TAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDL 557
Query: 675 NRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFW 734
+R+ P + F LRRVL A++++NPTIGYCQ +N + ++ LL EEE AFW
Sbjct: 558 HRSMPEHPAFQNELGIAA--LRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEE-AFW 614
Query: 735 CLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFL 794
LVA+ E ++P DYY + + VDQ + ++L + LP+L + V +S ++ +WFL
Sbjct: 615 LLVALCERMLP-DYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGV-ISSISLSWFL 672
Query: 795 VVFADSLISNILLRVWDAFLYEGTK 819
+F + + + D F YEG K
Sbjct: 673 TLFLSVMPFESAVVIVDCFFYEGIK 697
>gi|45597175 TBC1 domain family, member 9B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1250
Score = 114 bits (286), Expect = 3e-25
Identities = 69/205 (33%), Positives = 111/205 (54%), Gaps = 5/205 (2%)
Query: 615 SAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDL 674
+A+ + L+ G+P R +W + + PG Y EL+ + + A +IE DL
Sbjct: 498 TAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDL 557
Query: 675 NRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFW 734
+R+ P + F LRRVL A++++NPTIGYCQ +N + ++ LL EEE AFW
Sbjct: 558 HRSMPEHPAFQNELGIAA--LRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEE-AFW 614
Query: 735 CLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFL 794
LVA+ E ++P DYY + + VDQ + ++L + LP+L + V +S ++ +WFL
Sbjct: 615 LLVALCERMLP-DYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGV-ISSISLSWFL 672
Query: 795 VVFADSLISNILLRVWDAFLYEGTK 819
+F + + + D F YEG K
Sbjct: 673 TLFLSVMPFESAVVIVDCFFYEGIK 697
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 110 bits (276), Expect = 5e-24
Identities = 112/383 (29%), Positives = 173/383 (45%), Gaps = 34/383 (8%)
Query: 538 EALQWEAGEASSDS-IELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLE 596
E+L + SDS I + K D+YGFL Y L + I +R L L+
Sbjct: 281 ESLADDVSSMGSDSEINGLALRKTDKYGFLGGSQYSGS---LESSIPVDVARQRELKWLD 337
Query: 597 AV---DRPLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQ 653
D+ L R+ ++K R G+P R + W++L + + PG ++
Sbjct: 338 MFSNWDKWLSRRFQ---------KVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFE 388
Query: 654 ELLSRGQAREHPAARQ-IELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYC 712
EL +A P IE DL+R FP ++ F L R+L A++ P GYC
Sbjct: 389 EL---ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYC 445
Query: 713 QGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLP 772
Q +AA+ L+ + E+ AFWCLV I + +P YY L A Q+D + LL P
Sbjct: 446 QAQAPVAAVLLMHMPAEQ-AFWCLVQICDKYLPG-YYSAGLEAIQLDGEIFFALLRRASP 503
Query: 773 RLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKYNEK-EILRLQNG 831
HL + +D L WF+ +FA +L +LRVWD F EG K + ++ L++
Sbjct: 504 LAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHT 563
Query: 832 LEIYQYLRFFTKTISNSRKLMNIAFNDM-NPFRMKQLRQL----RMVHRERLEAELRELE 886
L + LR +L N+ M F + ++ L ++ RE A+L++
Sbjct: 564 LGSVEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIEREN-AAQLKKWR 622
Query: 887 QLKAEYLERRASRR----RAVSE 905
+ + E L+ R SRR RA+ E
Sbjct: 623 ETRGE-LQYRPSRRLHGSRAIHE 644
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 109 bits (273), Expect = 1e-23
Identities = 93/303 (30%), Positives = 138/303 (45%), Gaps = 18/303 (5%)
Query: 520 ALGDEASECSELLRQLVQEALQWEAGEASSDSIELSPIS--KYDEYGFLTVPDYEVEDLK 577
A G+ S E L Q A E SDS E + + + D++GF+ V E
Sbjct: 14 AAGESLSGTRESLAQGPDAATTDELSSLGSDS-EANGFAERRIDKFGFI-VGSQGAEGAL 71
Query: 578 LLAKIQALESRSHHLLGLEAVDRPLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRW 637
++ L R L + ++W A +++ + G+P R R W++
Sbjct: 72 EEVPLEVLRQRESKWLDM----LNNWDKWMAK----KHKKIRLRCQKGIPPSLRGRAWQY 123
Query: 638 LVHLRVQHLHTPGCYQEL-LSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLR 696
L +V+ PG + EL +S G + IE DL+R FP ++ F L
Sbjct: 124 LSGGKVKLQQNPGKFDELDMSPGDPKWLDV---IERDLHRQFPFHEMFVSRGGHGQQDLF 180
Query: 697 RVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTAS 756
RVL A++ P GYCQ +AA+ L+ + E+ AFWCLV I E +P YY L A
Sbjct: 181 RVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQ-AFWCLVQICEKYLPG-YYSEKLEAI 238
Query: 757 QVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYE 816
Q+D +L LL + P HL + +D L WF+ F+ +L + +LRVWD F E
Sbjct: 239 QLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCE 298
Query: 817 GTK 819
G K
Sbjct: 299 GVK 301
>gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 105 bits (263), Expect = 1e-22
Identities = 88/288 (30%), Positives = 135/288 (46%), Gaps = 45/288 (15%)
Query: 622 LRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHP------AARQIELDLN 675
L G+P+E R +VW L +LH+ + R E QI DL+
Sbjct: 83 LSTGIPKEWRRKVWLTLAD---HYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQIVKDLH 139
Query: 676 RTFPNNKHFTCPTSSFPDK--LRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLE-EEESA 732
RT ++ C + D+ L+RVLLA++ N T+GYCQG N LAA+ L V+E E A
Sbjct: 140 RTGCSSY---CGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDA 196
Query: 733 FWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHL------------GQ 780
++ +++ ++P Y+ N L A VD V +DLL KLP L HL G
Sbjct: 197 LKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGG 256
Query: 781 HHVDLSLV-TFNWFLVVFADSLISNILLRVWDAFLYEGTKYNEKEILRL----------- 828
+ L+ V T WFL +FA L + +L++WD+ +EG++ + L +
Sbjct: 257 YEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECC 316
Query: 829 QNGLEIYQYLRFFTK-----TISNSRKLMNIAFNDMNPFRMKQLRQLR 871
+ E Y + T+ + S +LM ++ M PF QL +LR
Sbjct: 317 ETADEFYSTMGRLTQEMLENDLLQSHELMQTVYS-MAPFPFPQLAELR 363
>gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 105 bits (263), Expect = 1e-22
Identities = 88/288 (30%), Positives = 135/288 (46%), Gaps = 45/288 (15%)
Query: 622 LRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHP------AARQIELDLN 675
L G+P+E R +VW L +LH+ + R E QI DL+
Sbjct: 83 LSTGIPKEWRRKVWLTLAD---HYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQIVKDLH 139
Query: 676 RTFPNNKHFTCPTSSFPDK--LRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLE-EEESA 732
RT ++ C + D+ L+RVLLA++ N T+GYCQG N LAA+ L V+E E A
Sbjct: 140 RTGCSSY---CGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDA 196
Query: 733 FWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHL------------GQ 780
++ +++ ++P Y+ N L A VD V +DLL KLP L HL G
Sbjct: 197 LKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGG 256
Query: 781 HHVDLSLV-TFNWFLVVFADSLISNILLRVWDAFLYEGTKYNEKEILRL----------- 828
+ L+ V T WFL +FA L + +L++WD+ +EG++ + L +
Sbjct: 257 YEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECC 316
Query: 829 QNGLEIYQYLRFFTK-----TISNSRKLMNIAFNDMNPFRMKQLRQLR 871
+ E Y + T+ + S +LM ++ M PF QL +LR
Sbjct: 317 ETADEFYSTMGRLTQEMLENDLLQSHELMQTVYS-MAPFPFPQLAELR 363
>gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 105 bits (263), Expect = 1e-22
Identities = 88/288 (30%), Positives = 135/288 (46%), Gaps = 45/288 (15%)
Query: 622 LRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHP------AARQIELDLN 675
L G+P+E R +VW L +LH+ + R E QI DL+
Sbjct: 83 LSTGIPKEWRRKVWLTLAD---HYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQIVKDLH 139
Query: 676 RTFPNNKHFTCPTSSFPDK--LRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLE-EEESA 732
RT ++ C + D+ L+RVLLA++ N T+GYCQG N LAA+ L V+E E A
Sbjct: 140 RTGCSSY---CGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDA 196
Query: 733 FWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHL------------GQ 780
++ +++ ++P Y+ N L A VD V +DLL KLP L HL G
Sbjct: 197 LKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGG 256
Query: 781 HHVDLSLV-TFNWFLVVFADSLISNILLRVWDAFLYEGTKYNEKEILRL----------- 828
+ L+ V T WFL +FA L + +L++WD+ +EG++ + L +
Sbjct: 257 YEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECC 316
Query: 829 QNGLEIYQYLRFFTK-----TISNSRKLMNIAFNDMNPFRMKQLRQLR 871
+ E Y + T+ + S +LM ++ M PF QL +LR
Sbjct: 317 ETADEFYSTMGRLTQEMLENDLLQSHELMQTVYS-MAPFPFPQLAELR 363
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 100 bits (249), Expect = 6e-21
Identities = 90/342 (26%), Positives = 156/342 (45%), Gaps = 47/342 (13%)
Query: 561 DEYGFL---TVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLR--ERWAALGDLVPS 615
D +GFL +PD+ V A+E + H L +E + L+ + W + +
Sbjct: 46 DRFGFLHEEELPDHNV----------AVERQKH--LEIERTTKWLKMLKGWEKYKN---T 90
Query: 616 AELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLN 675
+ + + G+P + R VW L+ + T Y +L R + P RQI+LD+N
Sbjct: 91 EKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCS-PDIRQIDLDVN 149
Query: 676 RTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWC 735
RTF ++ F L VL A+S N +GYCQG++++ A+ L+ + EE+ AFW
Sbjct: 150 RTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEED-AFWA 208
Query: 736 LVAIVETIMPA--DYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWF 793
LV + A ++ Q + +L++ L +L HL + S T WF
Sbjct: 209 LVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWF 268
Query: 794 LVVFADSLISNILLRVWDAFLYEG-----------TKYNEKEILRLQNGLEIYQYLRFFT 842
F D + LR+WD +++EG K ++K +++ L + + + FF
Sbjct: 269 FQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMK----LSMEELVEFFQ 324
Query: 843 KTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRE 884
+T++ + F D F ++QL Q+ M +R + +L E
Sbjct: 325 ETLAK-----DFFFED--DFVIEQL-QISMTELKRAKLDLPE 358
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 100 bits (249), Expect = 6e-21
Identities = 90/342 (26%), Positives = 156/342 (45%), Gaps = 47/342 (13%)
Query: 561 DEYGFL---TVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLR--ERWAALGDLVPS 615
D +GFL +PD+ V A+E + H L +E + L+ + W + +
Sbjct: 63 DRFGFLHEEELPDHNV----------AVERQKH--LEIERTTKWLKMLKGWEKYKN---T 107
Query: 616 AELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLN 675
+ + + G+P + R VW L+ + T Y +L R + P RQI+LD+N
Sbjct: 108 EKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCS-PDIRQIDLDVN 166
Query: 676 RTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWC 735
RTF ++ F L VL A+S N +GYCQG++++ A+ L+ + EE+ AFW
Sbjct: 167 RTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEED-AFWA 225
Query: 736 LVAIVETIMPA--DYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWF 793
LV + A ++ Q + +L++ L +L HL + S T WF
Sbjct: 226 LVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWF 285
Query: 794 LVVFADSLISNILLRVWDAFLYEG-----------TKYNEKEILRLQNGLEIYQYLRFFT 842
F D + LR+WD +++EG K ++K +++ L + + + FF
Sbjct: 286 FQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMK----LSMEELVEFFQ 341
Query: 843 KTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRE 884
+T++ + F D F ++QL Q+ M +R + +L E
Sbjct: 342 ETLAK-----DFFFED--DFVIEQL-QISMTELKRAKLDLPE 375
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 92.8 bits (229), Expect = 1e-18
Identities = 68/211 (32%), Positives = 102/211 (48%), Gaps = 12/211 (5%)
Query: 625 GVPREHRPRVWRWLV---HLRVQHLHTPGC----YQELLSRGQAREHPAARQIELDLNRT 677
GVPR HR +W++L HL+ Q Y+ELL + +++H I +DL RT
Sbjct: 800 GVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHA----ILIDLGRT 855
Query: 678 FPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLV 737
FP + +F+ + L +L A+S + +GYCQGL+ +A I LL + EEE AF L
Sbjct: 856 FPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEE-AFKMLK 914
Query: 738 AIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVF 797
++ + Y + Q+ L LL + L HL +H + SL WFL +F
Sbjct: 915 FLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMF 974
Query: 798 ADSLISNILLRVWDAFLYEGTKYNEKEILRL 828
A + RV+D +GT+ K L L
Sbjct: 975 ASQFPLGFVARVFDMIFLQGTEVIFKVALSL 1005
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 92.0 bits (227), Expect = 2e-18
Identities = 72/259 (27%), Positives = 123/259 (47%), Gaps = 17/259 (6%)
Query: 617 ELKQLLRAGVPREHRPRVWRWL-VHLRVQHLHTPG-------CYQELLSRGQAREHPAAR 668
++ LL+ GVP+ R +W++L + R++H P Y+ELL + A++H
Sbjct: 910 DIHTLLKEGVPKSRRGEIWQFLALQYRLRH-RLPNKQQPPDISYKELLKQLTAQQHA--- 965
Query: 669 QIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEE 728
I +DL RTFP + +F+ L +L A+S + +GYCQG++ +A + LL + E
Sbjct: 966 -ILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSE 1024
Query: 729 EESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLV 788
E+ AF L ++ + Y + + Q+ L LL + L HL ++ + SL
Sbjct: 1025 EQ-AFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLY 1083
Query: 789 TFNWFLVVFADSLISNILLRVWDAFLYEGTKYNEKEILRLQNGLEIYQYLRFFTKTISNS 848
WFL +FA + RV+D +GT+ K L L L + L ++ N
Sbjct: 1084 AAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSL---LSSQETLIMECESFENI 1140
Query: 849 RKLMNIAFNDMNPFRMKQL 867
+ + DMN M+++
Sbjct: 1141 VEFLKNTLPDMNTSEMEKI 1159
>gi|229577000 ecotropic viral integration site 5-like isoform 1
[Homo sapiens]
Length = 805
Score = 89.4 bits (220), Expect = 1e-17
Identities = 96/390 (24%), Positives = 165/390 (42%), Gaps = 50/390 (12%)
Query: 537 QEALQWEAGEASSDSIELSP-----ISKYDEYGFLTVPDYEVEDLKLL--------AKIQ 583
QEAL +SDS LSP ++K +E L D + ++ + + +
Sbjct: 13 QEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSK--SMRSMNGSRRNSGSSLV 70
Query: 584 ALESRSHHLLGLEAVDRPLRERWAALGDLVPSAE---------LKQLLRAGVPREHRPRV 634
+ S S +L LE + W G + E LK+L+R G+P R V
Sbjct: 71 SSSSASSNLSHLE------EDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIV 124
Query: 635 WRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDK 694
W+ L + Y ELL P + I D+ RT+P ++ F S +
Sbjct: 125 WQLLCS--ATDMPVKNQYSELLKMSS----PCEKLIRRDIARTYPEHEFFKGQDSLGQEV 178
Query: 695 LRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLT 754
L V+ A+S + +GYCQG + + L+ + EEE AF V +++ + + ++
Sbjct: 179 LFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEE-AFCVFVRLMQEYRLRELFKPSMA 237
Query: 755 ASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFL 814
+ + +L E+LP L H S+ +WFL +F + + RV+D F+
Sbjct: 238 ELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFM 297
Query: 815 YEG-----------TKYNEKEILRL-QNGLEIYQYLRFFTKTISNSRKLMNIAFN-DMNP 861
YEG + N+ E+++L G+ Y + S KL+ A+ NP
Sbjct: 298 YEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNP 357
Query: 862 FRMKQLRQLRMVHRERLEAELRELEQLKAE 891
+MK+L + + + E E+++L+ E
Sbjct: 358 KKMKRLEKEYAAMKSKEMEEQIEIKRLRTE 387
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 89.4 bits (220), Expect = 1e-17
Identities = 96/390 (24%), Positives = 165/390 (42%), Gaps = 50/390 (12%)
Query: 537 QEALQWEAGEASSDSIELSP-----ISKYDEYGFLTVPDYEVEDLKLL--------AKIQ 583
QEAL +SDS LSP ++K +E L D + ++ + + +
Sbjct: 13 QEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSK--SMRSMNGSRRNSGSSLV 70
Query: 584 ALESRSHHLLGLEAVDRPLRERWAALGDLVPSAE---------LKQLLRAGVPREHRPRV 634
+ S S +L LE + W G + E LK+L+R G+P R V
Sbjct: 71 SSSSASSNLSHLE------EDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIV 124
Query: 635 WRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDK 694
W+ L + Y ELL P + I D+ RT+P ++ F S +
Sbjct: 125 WQLLCS--ATDMPVKNQYSELLKMSS----PCEKLIRRDIARTYPEHEFFKGQDSLGQEV 178
Query: 695 LRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLT 754
L V+ A+S + +GYCQG + + L+ + EEE AF V +++ + + ++
Sbjct: 179 LFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEE-AFCVFVRLMQEYRLRELFKPSMA 237
Query: 755 ASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFL 814
+ + +L E+LP L H S+ +WFL +F + + RV+D F+
Sbjct: 238 ELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFM 297
Query: 815 YEG-----------TKYNEKEILRL-QNGLEIYQYLRFFTKTISNSRKLMNIAFN-DMNP 861
YEG + N+ E+++L G+ Y + S KL+ A+ NP
Sbjct: 298 YEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNP 357
Query: 862 FRMKQLRQLRMVHRERLEAELRELEQLKAE 891
+MK+L + + + E E+++L+ E
Sbjct: 358 KKMKRLEKEYAAMKSKEMEEQIEIKRLRTE 387
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 86.3 bits (212), Expect = 1e-16
Identities = 77/293 (26%), Positives = 137/293 (46%), Gaps = 25/293 (8%)
Query: 618 LKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRT 677
L L+++GVP R VW+ L Y+ L+++ A+E R D++RT
Sbjct: 531 LSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDR-YRILITKDSAQESVITR----DIHRT 585
Query: 678 FPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLV 737
FP + +F + L ++ A+S + IGYCQG + LAA+ LL + EE+ AF LV
Sbjct: 586 FPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQ-AFCVLV 644
Query: 738 AIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVF 797
I+ D Y N L+ L+ E+LP L +H +++ + WFL +F
Sbjct: 645 KIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLF 704
Query: 798 ADSLISNILLRVWDAFLYEG-----------TKYNEKEILR--LQNGLEIYQ-YLRFFTK 843
++ + D L EG K +++++L+ + L+ ++ L +
Sbjct: 705 TAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYR 764
Query: 844 TISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRE---LEQLKAEYL 893
N+R+LM A N P K+L++ ++ E++L++ +++ K YL
Sbjct: 765 AEENARRLMEQACNIKVP--TKKLKKYEKEYQTMRESQLQQEDPMDRYKFVYL 815
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 84.7 bits (208), Expect = 4e-16
Identities = 71/301 (23%), Positives = 131/301 (43%), Gaps = 29/301 (9%)
Query: 617 ELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNR 676
++K+L+ G+P R VW+ L Q + Y ELL P + I D+ R
Sbjct: 155 QVKELVHKGIPHHFRAIVWQLLCS--AQSMPIKDQYSELLKMTS----PCEKLIRRDIAR 208
Query: 677 TFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCL 736
T+P + F S + L V+ A+S + +GYCQG + + L+ + EEE AF
Sbjct: 209 TYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEE-AFCVF 267
Query: 737 VAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVV 796
V +++ + + ++ + + ++ E LP L H S+ +WFL +
Sbjct: 268 VKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTI 327
Query: 797 FADSLISNILLRVWDAFLYEG-----------TKYNEKEILRLQNGLEIYQYLRFFTKTI 845
F + I R++D F+ EG + N+ E+++ L++ L+ F K I
Sbjct: 328 FLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQ----LDMEGMLQHFQKVI 383
Query: 846 SNS-----RKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKAEYLERRASRR 900
+ KL+ A+ + K++++L + E+ E ++K E R ++
Sbjct: 384 PHQFDGVPDKLIQAAY--QVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQ 441
Query: 901 R 901
R
Sbjct: 442 R 442
Score = 34.3 bits (77), Expect = 0.55
Identities = 43/191 (22%), Positives = 80/191 (41%), Gaps = 21/191 (10%)
Query: 285 KRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQ-KELVKILHKALEAAQQEK 343
+++NN+ P I R + V E + +M KEL+ Q K+L + + L
Sbjct: 492 EKRNNSLPD-ENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQRHLARTTGRW 550
Query: 344 RASSAYLAAAEDKDRLELVRHKVRQ----IAELGRRVEALEQERESLAHTASLREQQVQE 399
+ A E +D L +R + + I E+ +R+ +E + + ++ EQ+V
Sbjct: 551 KDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRRAEQEVIS 610
Query: 400 LQQHVQLLMDKN-----------HAKQQVICKLSEKVTQDFTHPPDQ----SPLRPDAAN 444
LQ+ VQ L +N + ++ CK E+V D + LR A
Sbjct: 611 LQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAAVAELRQHIAE 670
Query: 445 RDFLSQQGKIE 455
+ ++GK++
Sbjct: 671 LEIQKEEGKLQ 681
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 84.0 bits (206), Expect = 6e-16
Identities = 60/206 (29%), Positives = 101/206 (49%), Gaps = 6/206 (2%)
Query: 615 SAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDL 674
S++L + G+P R VW L++++ L PG YQ + RG+ R I+LD+
Sbjct: 90 SSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMKERGK-RSSEHIHHIDLDV 148
Query: 675 NRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFW 734
T N+ F + +L +LLA+S NP +GYC+ L+ + A+ LL L EE+ AFW
Sbjct: 149 RTTLRNHVFFRDRYGAKQRELFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEED-AFW 207
Query: 735 CLVAIVET---IMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFN 791
LV ++ + +P + N T + Q + ++ + P+ M H + + +
Sbjct: 208 ALVQLLASERHSLPGFHSPNGGTVQGL-QDQQEHVVPKSQPKTMWHQDKEGLCGQCASLG 266
Query: 792 WFLVVFADSLISNILLRVWDAFLYEG 817
L D + + LR+WD +L EG
Sbjct: 267 CLLRNLIDGISLGLTLRLWDVYLVEG 292
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 82.4 bits (202), Expect = 2e-15
Identities = 79/303 (26%), Positives = 132/303 (43%), Gaps = 27/303 (8%)
Query: 617 ELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNR 676
+L L+R GVP R VW+ L + H Y+ L+++ E P I D+NR
Sbjct: 558 QLSSLVRNGVPEALRGEVWQLLAGCH-NNDHLVEKYRILITK----ESPQDSAITRDINR 612
Query: 677 TFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCL 736
TFP + +F D L ++ A+S + IGYCQG + LAA+ LL + EE+ AF L
Sbjct: 613 TFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQ-AFSVL 671
Query: 737 VAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVV 796
V I+ + + L+ L+ E +P L H ++ + WFL +
Sbjct: 672 VKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTL 731
Query: 797 FADSLISNILLRVWDAFLYEGTKYNEKEILRL----QNGLEIYQY---LRFFT------- 842
F ++ + D L EG L L ++ L + + L+FF
Sbjct: 732 FTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRY 791
Query: 843 KTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKAEYLERRASRRRA 902
++ N++KLM +A N ++ Q ++ E+ +RE + + + +ER R
Sbjct: 792 RSEENAKKLMELACN-------MKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRR 844
Query: 903 VSE 905
+ E
Sbjct: 845 LQE 847
>gi|38570103 TBC1 domain family, member 8B (with GRAM domain)
isoform b [Homo sapiens]
Length = 632
Score = 80.5 bits (197), Expect = 7e-15
Identities = 60/211 (28%), Positives = 100/211 (47%), Gaps = 11/211 (5%)
Query: 549 SDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLRERWAA 608
SD+ E+ ++ E E L + Q LE+ + +L + ++ + +A
Sbjct: 412 SDNFEVQSLTSQRECS----KTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAE 467
Query: 609 LG---DLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHP 665
G + + + + L+ G+P R +W P Y E++ + +
Sbjct: 468 CGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNL 527
Query: 666 AARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLV 725
A +IE DL R+ P + F T LRRVL A++++NP IGYCQ +N L ++ LL
Sbjct: 528 ATEEIERDLRRSLPEHPAFQSDTGI--SALRRVLTAYAYRNPKIGYCQAMNILTSVLLLY 585
Query: 726 LEEEESAFWCLVAIVETIMPADYYCNTLTAS 756
+EEE AFW LVA+ E ++P DY+ + S
Sbjct: 586 AKEEE-AFWLLVAVCERMLP-DYFNRRIIGS 614
>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
Length = 549
Score = 78.2 bits (191), Expect = 3e-14
Identities = 59/221 (26%), Positives = 105/221 (47%), Gaps = 8/221 (3%)
Query: 603 RERWA-ALGDLVPSAELKQLL-RA--GVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSR 658
+ +W LGD ++L+ RA G+P R +W L+++ L PG YQ + +
Sbjct: 75 KSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEK 134
Query: 659 GQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRL 718
G+ R ++I+ D++ T + F + +L +LLA+ NP +GYC+ L+ +
Sbjct: 135 GK-RSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHI 193
Query: 719 AAIALLVLEEEESAFWCLVAIV--ETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMA 776
AA+ LL L EE+ AFW LV ++ E ++ Q Q + +++ P+ M
Sbjct: 194 AALFLLYLPEED-AFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMG 252
Query: 777 HLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEG 817
H + + + + D + + LR+WD +L EG
Sbjct: 253 HQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEG 293
>gi|157502205 TBC1 domain family, member 3G [Homo sapiens]
Length = 549
Score = 78.2 bits (191), Expect = 3e-14
Identities = 59/221 (26%), Positives = 105/221 (47%), Gaps = 8/221 (3%)
Query: 603 RERWA-ALGDLVPSAELKQLL-RA--GVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSR 658
+ +W LGD ++L+ RA G+P R +W L+++ L PG YQ + +
Sbjct: 75 KSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEK 134
Query: 659 GQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRL 718
G+ R ++I+ D++ T + F + +L +LLA+ NP +GYC+ L+ +
Sbjct: 135 GK-RSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHI 193
Query: 719 AAIALLVLEEEESAFWCLVAIV--ETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMA 776
AA+ LL L EE+ AFW LV ++ E ++ Q Q + +++ P+ M
Sbjct: 194 AALFLLYLPEED-AFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMG 252
Query: 777 HLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEG 817
H + + + + D + + LR+WD +L EG
Sbjct: 253 HQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEG 293
>gi|183583565 TBC1 domain family, member 3 [Homo sapiens]
Length = 549
Score = 77.0 bits (188), Expect = 7e-14
Identities = 59/221 (26%), Positives = 105/221 (47%), Gaps = 8/221 (3%)
Query: 603 RERWA-ALGDLVPSAELKQLL-RA--GVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSR 658
+ +W LGD ++L+ RA G+P R +W L+++ L PG YQ + +
Sbjct: 75 KSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEK 134
Query: 659 GQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRL 718
G+ R ++I+ D++ T + F + +L +LLA+ NP +GYC+ L+ +
Sbjct: 135 GK-RSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHI 193
Query: 719 AAIALLVLEEEESAFWCLVAIV--ETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMA 776
AA+ LL L EE+ AFW LV ++ E ++ Q Q + +++ P+ M
Sbjct: 194 AALFLLYLPEED-AFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMG 252
Query: 777 HLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEG 817
H + + + + D + + LR+WD +L EG
Sbjct: 253 HQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEG 293
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,999,714
Number of Sequences: 37866
Number of extensions: 1848189
Number of successful extensions: 14571
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 663
Number of HSP's that attempted gapping in prelim test: 11981
Number of HSP's gapped (non-prelim): 2741
length of query: 917
length of database: 18,247,518
effective HSP length: 111
effective length of query: 806
effective length of database: 14,044,392
effective search space: 11319779952
effective search space used: 11319779952
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.