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Search of human proteins with 221625547
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221625547 neutral sphingomyelinase (N-SMase) activation
associated factor isoform 2 [Homo sapiens]
(948 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221625547 neutral sphingomyelinase (N-SMase) activation assoc... 1944 0.0
gi|31543297 neutral sphingomyelinase (N-SMase) activation associ... 1839 0.0
gi|224451124 neurobeachin-like 1 isoform 3 [Homo sapiens] 336 5e-92
gi|149944613 neurobeachin-like 1 isoform 1 [Homo sapiens] 336 5e-92
gi|154240744 neurobeachin-like 1 isoform 2 [Homo sapiens] 320 3e-87
gi|62422577 neurobeachin [Homo sapiens] 313 6e-85
gi|148233596 LPS-responsive vesicle trafficking, beach and ancho... 312 8e-85
gi|149944548 neurobeachin-like 2 [Homo sapiens] 304 2e-82
gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Ho... 294 2e-79
gi|191252801 WDFY family member 4 [Homo sapiens] 273 6e-73
gi|54292123 lysosomal trafficking regulator [Homo sapiens] 252 1e-66
gi|239756689 PREDICTED: WD repeat domain 81 [Homo sapiens] 104 3e-22
gi|239751186 PREDICTED: WD repeat domain 81 [Homo sapiens] 104 3e-22
gi|239745674 PREDICTED: WD repeat domain 81 [Homo sapiens] 104 3e-22
gi|16554629 WD repeat domain 5 [Homo sapiens] 102 2e-21
gi|16554627 WD repeat domain 5 [Homo sapiens] 102 2e-21
gi|23199987 WD repeat domain 5B [Homo sapiens] 94 5e-19
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 94 6e-19
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 94 6e-19
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 94 6e-19
gi|32189425 WD repeat domain 69 [Homo sapiens] 94 6e-19
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 92 2e-18
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 92 2e-18
gi|26665869 WD repeat domain 51B [Homo sapiens] 90 9e-18
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 85 4e-16
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 79 2e-14
gi|157266266 WD repeat domain 86 [Homo sapiens] 79 2e-14
gi|113865883 WD repeat domain 38 [Homo sapiens] 79 3e-14
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 78 3e-14
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 75 4e-13
>gi|221625547 neutral sphingomyelinase (N-SMase) activation
associated factor isoform 2 [Homo sapiens]
Length = 948
Score = 1944 bits (5037), Expect = 0.0
Identities = 948/948 (100%), Positives = 948/948 (100%)
Query: 1 MTGQARFHRGAEACRAIRQCRSRRPRAAHPEGRAGSGRGSRHASPGVRRGGFSLLLLNLE 60
MTGQARFHRGAEACRAIRQCRSRRPRAAHPEGRAGSGRGSRHASPGVRRGGFSLLLLNLE
Sbjct: 1 MTGQARFHRGAEACRAIRQCRSRRPRAAHPEGRAGSGRGSRHASPGVRRGGFSLLLLNLE 60
Query: 61 EYYFEQHRANHILHKGSHHERKIRGSLKICSKSVIFEPDSISQPIIKIPLRDCIKIGKHG 120
EYYFEQHRANHILHKGSHHERKIRGSLKICSKSVIFEPDSISQPIIKIPLRDCIKIGKHG
Sbjct: 61 EYYFEQHRANHILHKGSHHERKIRGSLKICSKSVIFEPDSISQPIIKIPLRDCIKIGKHG 120
Query: 121 ENGANRHFTKAKSGGISLIFSQVYFIKEHNVVAPYKIERGKMEYVFELDVPGKVEDVVET 180
ENGANRHFTKAKSGGISLIFSQVYFIKEHNVVAPYKIERGKMEYVFELDVPGKVEDVVET
Sbjct: 121 ENGANRHFTKAKSGGISLIFSQVYFIKEHNVVAPYKIERGKMEYVFELDVPGKVEDVVET 180
Query: 181 LLQLHRASCLDKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKAEMVTPLVTN 240
LLQLHRASCLDKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKAEMVTPLVTN
Sbjct: 181 LLQLHRASCLDKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKAEMVTPLVTN 240
Query: 241 PGHVCITDTNLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCTEDDLCSDIY 300
PGHVCITDTNLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCTEDDLCSDIY
Sbjct: 241 PGHVCITDTNLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCTEDDLCSDIY 300
Query: 301 LKFYEPQDRDDLYFYIATYLEHHVAEHTAESYMLQWQRGHLSNYQYLLHLNNLADRSCND 360
LKFYEPQDRDDLYFYIATYLEHHVAEHTAESYMLQWQRGHLSNYQYLLHLNNLADRSCND
Sbjct: 301 LKFYEPQDRDDLYFYIATYLEHHVAEHTAESYMLQWQRGHLSNYQYLLHLNNLADRSCND 360
Query: 361 LSQYPVFPWIIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEPKFMYG 420
LSQYPVFPWIIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEPKFMYG
Sbjct: 361 LSQYPVFPWIIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEPKFMYG 420
Query: 421 SHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEF 480
SHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEF
Sbjct: 421 SHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEF 480
Query: 481 YGDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEW 540
YGDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEW
Sbjct: 481 YGDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEW 540
Query: 541 IDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFV 600
IDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFV
Sbjct: 541 IDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFV 600
Query: 601 TPHPRRITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYKIH 660
TPHPRRITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYKIH
Sbjct: 601 TPHPRRITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYKIH 660
Query: 661 KEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVIT 720
KEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVIT
Sbjct: 661 KEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVIT 720
Query: 721 SSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGT 780
SSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGT
Sbjct: 721 SSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGT 780
Query: 781 KRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVC 840
KRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVC
Sbjct: 781 KRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVC 840
Query: 841 DTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVWDGNSVLSGSQSGELL 900
DTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVWDGNSVLSGSQSGELL
Sbjct: 841 DTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVWDGNSVLSGSQSGELL 900
Query: 901 VWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQY 948
VWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQY
Sbjct: 901 VWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQY 948
>gi|31543297 neutral sphingomyelinase (N-SMase) activation
associated factor isoform 1 [Homo sapiens]
Length = 917
Score = 1839 bits (4763), Expect = 0.0
Identities = 897/897 (100%), Positives = 897/897 (100%)
Query: 52 FSLLLLNLEEYYFEQHRANHILHKGSHHERKIRGSLKICSKSVIFEPDSISQPIIKIPLR 111
FSLLLLNLEEYYFEQHRANHILHKGSHHERKIRGSLKICSKSVIFEPDSISQPIIKIPLR
Sbjct: 21 FSLLLLNLEEYYFEQHRANHILHKGSHHERKIRGSLKICSKSVIFEPDSISQPIIKIPLR 80
Query: 112 DCIKIGKHGENGANRHFTKAKSGGISLIFSQVYFIKEHNVVAPYKIERGKMEYVFELDVP 171
DCIKIGKHGENGANRHFTKAKSGGISLIFSQVYFIKEHNVVAPYKIERGKMEYVFELDVP
Sbjct: 81 DCIKIGKHGENGANRHFTKAKSGGISLIFSQVYFIKEHNVVAPYKIERGKMEYVFELDVP 140
Query: 172 GKVEDVVETLLQLHRASCLDKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKA 231
GKVEDVVETLLQLHRASCLDKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKA
Sbjct: 141 GKVEDVVETLLQLHRASCLDKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKA 200
Query: 232 EMVTPLVTNPGHVCITDTNLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCT 291
EMVTPLVTNPGHVCITDTNLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCT
Sbjct: 201 EMVTPLVTNPGHVCITDTNLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCT 260
Query: 292 EDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTAESYMLQWQRGHLSNYQYLLHLN 351
EDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTAESYMLQWQRGHLSNYQYLLHLN
Sbjct: 261 EDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTAESYMLQWQRGHLSNYQYLLHLN 320
Query: 352 NLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQE 411
NLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQE
Sbjct: 321 NLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQE 380
Query: 412 MPEPKFMYGSHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETWKNCLDGAT 471
MPEPKFMYGSHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETWKNCLDGAT
Sbjct: 381 MPEPKFMYGSHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETWKNCLDGAT 440
Query: 472 DFKELIPEFYGDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASSPEDFLQKSKDALESN 531
DFKELIPEFYGDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASSPEDFLQKSKDALESN
Sbjct: 441 DFKELIPEFYGDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASSPEDFLQKSKDALESN 500
Query: 532 YVSEHLHEWIDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEF 591
YVSEHLHEWIDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEF
Sbjct: 501 YVSEHLHEWIDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEF 560
Query: 592 GQTPKQLFVTPHPRRITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKL 651
GQTPKQLFVTPHPRRITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKL
Sbjct: 561 GQTPKQLFVTPHPRRITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKL 620
Query: 652 QLHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLL 711
QLHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLL
Sbjct: 621 QLHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLL 680
Query: 712 LPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWS 771
LPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWS
Sbjct: 681 LPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWS 740
Query: 772 GVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQ 831
GVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQ
Sbjct: 741 GVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQ 800
Query: 832 IPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVWDGNSVL 891
IPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVWDGNSVL
Sbjct: 801 IPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVWDGNSVL 860
Query: 892 SGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQY 948
SGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQY
Sbjct: 861 SGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQY 917
>gi|224451124 neurobeachin-like 1 isoform 3 [Homo sapiens]
Length = 2694
Score = 336 bits (862), Expect = 5e-92
Identities = 255/794 (32%), Positives = 396/794 (49%), Gaps = 73/794 (9%)
Query: 209 ARTSFDKNRFQNISEKLHMECKAEMVTPLVTNPGHVCITDTNLYFQPLNGYPKPVVQITL 268
AR + D+ Q+ EKL + E++T + PG + IT ++YF + + V
Sbjct: 1872 ARVNVDEKEEQDQKEKLVLMEDCELITIIDVIPGRLEITTQHIYFYDGSIEKEDGVGFDF 1931
Query: 269 Q----DVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIAT------ 318
+ +R I+ RR+ L LE+F + S+ +L F + + R+ +Y + +
Sbjct: 1932 KWPHSQIREIHLRRYNLRRSALEIFHVDQ---SNYFLNF-KKEVRNKIYSRLLSLHSPNS 1987
Query: 319 -YLEHHVAEHTAESYMLQ-WQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSS 376
Y E S + Q W +SN+ YL+ +N +A R+ NDL+QYPVFPWI+ DY+S
Sbjct: 1988 YYGSRSPQELFKASGLTQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTS 2047
Query: 377 SELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEP-----KFMYGSHYSSPGYVLF 431
ELDL+NP FRDLSKP+G +N++ + + +Y+ +P KF YG+HYS+ V+
Sbjct: 2048 EELDLNNPAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMH 2107
Query: 432 YLVRIAPEYMLC--LQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYGDDVSFLV 489
YL+R+ P L LQ+GRFD ADR F+SI TW+ +D D KELIPEF+ FL
Sbjct: 2108 YLIRVEPFTTLHIQLQSGRFDCADRQFHSIPATWQALMDNPYDVKELIPEFFYFP-EFLE 2166
Query: 490 NSLKLDLGKRQ-GGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYK 548
N + +LG+ Q ++V+DV LP WA S EDF+ K + ALES YVS HLHEWIDLIFGYK
Sbjct: 2167 NQNQFNLGRLQISKELVNDVILPKWAKSAEDFIYKHRKALESEYVSAHLHEWIDLIFGYK 2226
Query: 549 QKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRIT 608
Q+G AV A NVF+ +YEG VDL+++ D E+ A+ I FGQTP QL PHP R++
Sbjct: 2227 QRGPAAVEALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLLKEPHPPRLS 2286
Query: 609 P----KFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYK------ 658
+ + TS+ N + F + + L I K Q
Sbjct: 2287 AEEAVQKPTKIDTSTLNLFQHLPELKSFFIEGISDGIPLLKATIPKNQYRSFMSQGSPEL 2346
Query: 659 ---IHKEAVTG----ITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLL 711
I V G + RN S+ FT +D T+ K + + S + S +
Sbjct: 2347 LITISMNYVIGTHGWLPYDRNISNYFTFIKDQTVTN-PKTQRSINGSFAPGLEITSKLFV 2405
Query: 712 LPGDATVITSS--WDNNVYFYSIAFGRRQDTLMGHDDAVSKIC--WHDNRLYSASWDSTV 767
+ DA ++ S+ WDN++ S+ G+ ++ H D V+ + + L S S D+T
Sbjct: 2406 VSHDAKLLFSAGYWDNSIQVMSLTKGKIISHIIRHMDIVTCLATDYCGIHLISGSRDTTC 2465
Query: 768 KVW-----SGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWD 822
+W GVP G F +L H V ++ ++ + VSG+++GTV I
Sbjct: 2466 MIWQITQQGGVPV---GLASKPFQIL--YGHTNEVLSVGISTELDMAVSGSRDGTVIIHT 2520
Query: 823 LTTATLMHQI--PCHSGI---VCDTAFSPDSRHVLSTGTD--------GCLNVIDVQTGM 869
+ M + PC S + + + A S + V+ + T+ L++ +
Sbjct: 2521 IQKGQYMRTLRPPCESSLFLTIPNLAISWEGHIVVYSSTEEKTTLKDKNALHLFSINGKY 2580
Query: 870 LISSMTSDE-PQRCFVWDGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQ 928
L S + ++ C + G +++GS G L + DL +S + C+ + ++
Sbjct: 2581 LGSQILKEQVSDICII--GEHIVTGSIQGFLSIRDLHSLNLSINPLAMRLPIHCVCVTKE 2638
Query: 929 CSSIITGGEDRQII 942
S I+ G ED ++I
Sbjct: 2639 YSHILVGLEDGKLI 2652
>gi|149944613 neurobeachin-like 1 isoform 1 [Homo sapiens]
Length = 1404
Score = 336 bits (862), Expect = 5e-92
Identities = 255/794 (32%), Positives = 396/794 (49%), Gaps = 73/794 (9%)
Query: 209 ARTSFDKNRFQNISEKLHMECKAEMVTPLVTNPGHVCITDTNLYFQPLNGYPKPVVQITL 268
AR + D+ Q+ EKL + E++T + PG + IT ++YF + + V
Sbjct: 582 ARVNVDEKEEQDQKEKLVLMEDCELITIIDVIPGRLEITTQHIYFYDGSIEKEDGVGFDF 641
Query: 269 Q----DVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIAT------ 318
+ +R I+ RR+ L LE+F + S+ +L F + + R+ +Y + +
Sbjct: 642 KWPHSQIREIHLRRYNLRRSALEIFHVDQ---SNYFLNF-KKEVRNKIYSRLLSLHSPNS 697
Query: 319 -YLEHHVAEHTAESYMLQ-WQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSS 376
Y E S + Q W +SN+ YL+ +N +A R+ NDL+QYPVFPWI+ DY+S
Sbjct: 698 YYGSRSPQELFKASGLTQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTS 757
Query: 377 SELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEP-----KFMYGSHYSSPGYVLF 431
ELDL+NP FRDLSKP+G +N++ + + +Y+ +P KF YG+HYS+ V+
Sbjct: 758 EELDLNNPAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMH 817
Query: 432 YLVRIAPEYMLC--LQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYGDDVSFLV 489
YL+R+ P L LQ+GRFD ADR F+SI TW+ +D D KELIPEF+ FL
Sbjct: 818 YLIRVEPFTTLHIQLQSGRFDCADRQFHSIPATWQALMDNPYDVKELIPEFFYFP-EFLE 876
Query: 490 NSLKLDLGKRQ-GGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYK 548
N + +LG+ Q ++V+DV LP WA S EDF+ K + ALES YVS HLHEWIDLIFGYK
Sbjct: 877 NQNQFNLGRLQISKELVNDVILPKWAKSAEDFIYKHRKALESEYVSAHLHEWIDLIFGYK 936
Query: 549 QKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRIT 608
Q+G AV A NVF+ +YEG VDL+++ D E+ A+ I FGQTP QL PHP R++
Sbjct: 937 QRGPAAVEALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLLKEPHPPRLS 996
Query: 609 P----KFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYK------ 658
+ + TS+ N + F + + L I K Q
Sbjct: 997 AEEAVQKPTKIDTSTLNLFQHLPELKSFFIEGISDGIPLLKATIPKNQYRSFMSQGSPEL 1056
Query: 659 ---IHKEAVTG----ITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLL 711
I V G + RN S+ FT +D T+ K + + S + S +
Sbjct: 1057 LITISMNYVIGTHGWLPYDRNISNYFTFIKDQTVTN-PKTQRSINGSFAPGLEITSKLFV 1115
Query: 712 LPGDATVITSS--WDNNVYFYSIAFGRRQDTLMGHDDAVSKIC--WHDNRLYSASWDSTV 767
+ DA ++ S+ WDN++ S+ G+ ++ H D V+ + + L S S D+T
Sbjct: 1116 VSHDAKLLFSAGYWDNSIQVMSLTKGKIISHIIRHMDIVTCLATDYCGIHLISGSRDTTC 1175
Query: 768 KVW-----SGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWD 822
+W GVP G F +L H V ++ ++ + VSG+++GTV I
Sbjct: 1176 MIWQITQQGGVPV---GLASKPFQIL--YGHTNEVLSVGISTELDMAVSGSRDGTVIIHT 1230
Query: 823 LTTATLMHQI--PCHSGI---VCDTAFSPDSRHVLSTGTD--------GCLNVIDVQTGM 869
+ M + PC S + + + A S + V+ + T+ L++ +
Sbjct: 1231 IQKGQYMRTLRPPCESSLFLTIPNLAISWEGHIVVYSSTEEKTTLKDKNALHLFSINGKY 1290
Query: 870 LISSMTSDE-PQRCFVWDGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQ 928
L S + ++ C + G +++GS G L + DL +S + C+ + ++
Sbjct: 1291 LGSQILKEQVSDICII--GEHIVTGSIQGFLSIRDLHSLNLSINPLAMRLPIHCVCVTKE 1348
Query: 929 CSSIITGGEDRQII 942
S I+ G ED ++I
Sbjct: 1349 YSHILVGLEDGKLI 1362
>gi|154240744 neurobeachin-like 1 isoform 2 [Homo sapiens]
Length = 1335
Score = 320 bits (821), Expect = 3e-87
Identities = 246/777 (31%), Positives = 380/777 (48%), Gaps = 108/777 (13%)
Query: 209 ARTSFDKNRFQNISEKLHMECKAEMVTPLVTNPGHVCITDTNLYFQPLNGYPKPVVQITL 268
AR + D+ Q+ EKL + E++T + PG + IT ++YF + + V
Sbjct: 582 ARVNVDEKEEQDQKEKLVLMEDCELITIIDVIPGRLEITTQHIYFYDGSIEKEDGVGFDF 641
Query: 269 Q----DVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIAT------ 318
+ +R I+ RR+ L LE+F + S+ +L F + + R+ +Y + +
Sbjct: 642 KWPHSQIREIHLRRYNLRRSALEIFHVDQ---SNYFLNF-KKEVRNKIYSRLLSLHSPNS 697
Query: 319 -YLEHHVAEHTAESYMLQ-WQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSS 376
Y E S + Q W +SN+ YL+ +N +A R+ NDL+QYPVFPWI+ DY+S
Sbjct: 698 YYGSRSPQELFKASGLTQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTS 757
Query: 377 SELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEP-----KFMYGSHYSSPGYVLF 431
ELDL+NP FRDLSKP+G +N++ + + +Y+ +P KF YG+HYS+ V+
Sbjct: 758 EELDLNNPAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMH 817
Query: 432 YLVRIAPEYMLC--LQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYGDDVSFLV 489
YL+R+ P L LQ+GRFD ADR F+SI TW+ +D D KELIPEF+ FL
Sbjct: 818 YLIRVEPFTTLHIQLQSGRFDCADRQFHSIPATWQALMDNPYDVKELIPEFFYFP-EFLE 876
Query: 490 NSLKLDLGKRQ-GGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYK 548
N + +LG+ Q ++V+DV LP WA S EDF+ K + ALES YVS HLHEWIDLIFGYK
Sbjct: 877 NQNQFNLGRLQISKELVNDVILPKWAKSAEDFIYKHRKALESEYVSAHLHEWIDLIFGYK 936
Query: 549 QKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRIT 608
Q+G AV A NVF+ +YEG VDL+++ D E+ A+ I FGQTP QL
Sbjct: 937 QRGPAAVEALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQL---------- 986
Query: 609 PKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYKIHKEAVTGIT 668
L T S N + T W +
Sbjct: 987 -----LKITISMNYVIG----------------THGW---------------------LP 1004
Query: 669 VSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVITSS--WDNN 726
RN S+ FT +D T+ K + + S + S ++ DA ++ S+ WDN+
Sbjct: 1005 YDRNISNYFTFIKDQTVTN-PKTQRSINGSFAPGLEITSKLFVVSHDAKLLFSAGYWDNS 1063
Query: 727 VYFYSIAFGRRQDTLMGHDDAVSKIC--WHDNRLYSASWDSTVKVW-----SGVPAEMPG 779
+ S+ G+ ++ H D V+ + + L S S D+T +W GVP G
Sbjct: 1064 IQVMSLTKGKIISHIIRHMDIVTCLATDYCGIHLISGSRDTTCMIWQITQQGGVPV---G 1120
Query: 780 TKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQI--PCHSG 837
F +L H V ++ ++ + VSG+++GTV I + M + PC S
Sbjct: 1121 LASKPFQIL--YGHTNEVLSVGISTELDMAVSGSRDGTVIIHTIQKGQYMRTLRPPCESS 1178
Query: 838 I---VCDTAFSPDSRHVLSTGTD--------GCLNVIDVQTGMLISSMTSDE-PQRCFVW 885
+ + + A S + V+ + T+ L++ + L S + ++ C +
Sbjct: 1179 LFLTIPNLAISWEGHIVVYSSTEEKTTLKDKNALHLFSINGKYLGSQILKEQVSDICII- 1237
Query: 886 DGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQII 942
G +++GS G L + DL +S + C+ + ++ S I+ G ED ++I
Sbjct: 1238 -GEHIVTGSIQGFLSIRDLHSLNLSINPLAMRLPIHCVCVTKEYSHILVGLEDGKLI 1293
>gi|62422577 neurobeachin [Homo sapiens]
Length = 2946
Score = 313 bits (801), Expect = 6e-85
Identities = 245/849 (28%), Positives = 401/849 (47%), Gaps = 87/849 (10%)
Query: 172 GKVEDVVETLLQLHRASCLDKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKA 231
G EDVV++ + +++ + M+ A + + N++ + + A
Sbjct: 2102 GTEEDVVKSKKTFRSQAIVNQNAETELMLEG---DDDAVSLLQEKEIDNLAGPVVLSTPA 2158
Query: 232 EMVTPLVTNPGHVCITDTNLYFQ------PLNGYPKPVVQIT--------LQDVRRIYKR 277
+++ P+V G + IT T +YF+ V+ T ++R ++ R
Sbjct: 2159 QLIAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSR 2218
Query: 278 RHGLMPLGLEVFCTE--------DDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAE--- 326
R+ L LEVF D + + + P+ + + +A
Sbjct: 2219 RYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQ 2278
Query: 327 -HTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPG 385
+ + + +WQR +SN++YL+ LN +A R+ NDL+QYPVFPW++ +Y S ELDL+ PG
Sbjct: 2279 LYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPG 2338
Query: 386 TFRDLSKPVGALNKERLERLLTRYQEMPE---PKFMYGSHYSSPGYVLFYLVRIAP--EY 440
FRDLSKP+GALN +R RY+ + P + Y +HYS+ L +LVRI P +
Sbjct: 2339 NFRDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTF 2398
Query: 441 MLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYGDDVSFLVNSLKLDLGKRQ 500
L +G+FD+ DR F+S+A +W+ +D KELIPEFY F VNS +LG R+
Sbjct: 2399 FLNANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMF-VNSNGYNLGVRE 2457
Query: 501 GGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVGAHNV 560
+V+DV+LPPWA PEDF++ ++ ALES +VS LH+WIDLIFGYKQ+G +AV A NV
Sbjct: 2458 DEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNV 2517
Query: 561 FHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRITPKFKSLSQTSSY 620
FH LTYEG V+L+SI DP + AM QI FGQTP QL + PHP R ++ +
Sbjct: 2518 FHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPR---------SSAMH 2568
Query: 621 NASMADSP---GEESFEDLTEESKTLAWNNITKLQLHEHYKIHKEAVTGITVSR------ 671
+ SP ++ +D+ K + + +T + + + AV +T SR
Sbjct: 2569 LCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNR 2628
Query: 672 -------NGSSVFTTSQDSTL-----KMFSKESKMLQRSIS----FSNMALSSCLLLPGD 715
G+ ++ Q L + + S + +R I+ S + C ++ D
Sbjct: 2629 WHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTAD 2688
Query: 716 --ATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKIC------WHDNRLYSASWDSTV 767
+I WD + YS G+ + GH D V+ + D + S S D+T+
Sbjct: 2689 NRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATL 2748
Query: 768 KV--WSG---VPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWD 822
+ WSG + + P + + HD V +S+ A L++SG KEG +
Sbjct: 2749 LLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHT 2808
Query: 823 LTTATLMHQIPCHSGIVCDTAFSPDSR-HVLSTGTDGCLNVIDVQTGMLISSMTSDEPQR 881
+ T L+ + + S S H + G + + G L++ M ++ R
Sbjct: 2809 I-TGDLLRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNFSI-NGKLLAQMEINDSTR 2866
Query: 882 CFVW--DGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDR 939
+ DG ++++G +G + VW K G + + ++ ++ITG
Sbjct: 2867 AILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASG 2926
Query: 940 QIIFWKLQY 948
I+ + + +
Sbjct: 2927 SIVAFNIDF 2935
>gi|148233596 LPS-responsive vesicle trafficking, beach and anchor
containing [Homo sapiens]
Length = 2863
Score = 312 bits (800), Expect = 8e-85
Identities = 246/806 (30%), Positives = 381/806 (47%), Gaps = 93/806 (11%)
Query: 211 TSFDKNRFQNISEKLHMECKAEMVTPLVTNPGHVCITDTNLYFQPLNGYPK------PVV 264
+S D+ +N++ + + A++V P V G + +T + LYF+ P ++
Sbjct: 2064 SSVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKIL 2123
Query: 265 QIT--------LQDVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYI 316
T ++R I+ RR+ L LE+F + F +P + Y+
Sbjct: 2124 AYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVA---VMFNFPDPATVKKVVNYL 2180
Query: 317 ATY---------------LEHHVAEHTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDL 361
L A + +WQ +SN++YL+ LN +A RS NDL
Sbjct: 2181 PRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDL 2240
Query: 362 SQYPVFPWIIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPE---PKFM 418
+QYPVFPW+I +Y S ELDL+ P FRDLSKP+GALN +R RY+ + PKF
Sbjct: 2241 NQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFH 2300
Query: 419 YGSHYSSPGYVLFYLVRIAP--EYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKEL 476
YG+HYS+ +VL +L+RI P Y L LQ G+FD+ADR F+SI+ W+N +D KEL
Sbjct: 2301 YGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKEL 2360
Query: 477 IPEFYGDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEH 536
IPEFY F VN +LG G +V DVELPPWA + E+F+ ++ ALES +VS
Sbjct: 2361 IPEFYYLPEMF-VNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQ 2419
Query: 537 LHEWIDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPK 596
LH+WIDLIFGYKQ+G +AV A NVF+ LTYEG V+LNSI DP + A+ QI FGQTP
Sbjct: 2420 LHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPS 2479
Query: 597 QLFVTPHPRRITPKFKSLSQTSSYNASMADSP---GEESFEDLTEESKTLAWNNITKLQL 653
QL + PHP R ++M SP +++ +D+ K + + +T +
Sbjct: 2480 QLLIEPHPPR--------------GSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHVAA 2525
Query: 654 HEHYKIHKEAVTGITVSR--------NGSSVFTTSQDSTLK-------MFSKESKMLQRS 698
+ + AV +T +R N + QD + + + + M +R
Sbjct: 2526 NTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQ 2585
Query: 699 IS----FSNMALSSCLLLPGD--ATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKIC 752
I+ S S C ++ D ++ WD + YS GR + GH D V+ +
Sbjct: 2586 ITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLA 2645
Query: 753 WHDN------RLYSASWDSTVKVW------SGVPAEMPGTKRHHFDLLAELEHDVSVDTI 800
++ + S S D+T+ +W SG+ + PG++ + HD V
Sbjct: 2646 RSESYIGGNCYILSGSRDATLLLWYWNGKCSGI-GDNPGSETAAPRAIL-TGHDYEVTCA 2703
Query: 801 SLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCL 860
++ A L++SG++EG I + L + + + H + +G
Sbjct: 2704 AVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLF 2763
Query: 861 NVIDVQTGMLISSMTSDEPQRCFVW--DGNSVLSGSQSGELLVWDLLGAKISERIQGHTG 918
V G L ++M +D+ R DG +L+G G ++V + K G
Sbjct: 2764 CTFSV-NGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDA 2822
Query: 919 AVTCIWMNEQCSSIITGGEDRQIIFW 944
+ + ++ II+G I+ +
Sbjct: 2823 GIRAMALSYDQRCIISGMASGSIVLF 2848
>gi|149944548 neurobeachin-like 2 [Homo sapiens]
Length = 2754
Score = 304 bits (779), Expect = 2e-82
Identities = 226/709 (31%), Positives = 345/709 (48%), Gaps = 102/709 (14%)
Query: 191 DKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKAEMVTPLVTNPGHVCITDTN 250
D+LG+ A L++ + D+ R EKL + + ++VT + PG + +T N
Sbjct: 1894 DQLGEDEL---AELETPMEAAELDEQR-----EKLVLSAECQLVTVVAVVPGLLEVTTQN 1945
Query: 251 LYFQPLN----------GYP--KPVVQITLQDVRRIYKRRHGLMPLGLEVFCTEDDLCSD 298
+YF + GY +P+ Q+ R ++ RR L LE+F + ++
Sbjct: 1946 VYFYDGSTERVETEEGIGYDFRRPLAQL-----REVHLRRFNLRRSALELFFIDQ---AN 1997
Query: 299 IYLKFY------------------------EPQDRDDLYFYIAT-------YLEHHVAEH 327
+L F Q R+ +Y ++ YL +
Sbjct: 1998 YFLNFPCKVGTTPVSSPSQTPRPQPGPIPPHTQVRNQVYSWLLRLRPPSQGYLSSRSPQE 2057
Query: 328 T--AESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPG 385
A +W + +SN++YL+ LN +A R+ NDLSQYPVFPW++ DY S LDLSNP
Sbjct: 2058 MLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSNPA 2117
Query: 386 TFRDLSKPVGALNKERLERLLTRYQEMPEP-----KFMYGSHYSSPGYVLFYLVRIAPEY 440
FRDLSKP+G +N + + + +Y+ +P KF YG+HYS+ V+ YL+R+ P
Sbjct: 2118 VFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHYSNAAGVMHYLIRVEPFT 2177
Query: 441 MLC--LQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYGDDVSFLVNSLKLDLGK 498
L LQ+GRFD +DR F+S+A W+ L+ D KELIPEF+ FL N DLG
Sbjct: 2178 SLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVKELIPEFFYFP-DFLENQNGFDLGC 2236
Query: 499 RQ-GGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVGA 557
Q + V DV LPPWASSPEDF+Q+ + ALES YVS HLHEWIDLIFGYKQ+G A A
Sbjct: 2237 LQLTNEKVGDVVLPPWASSPEDFIQQHRQALESEYVSAHLHEWIDLIFGYKQRGPAAEEA 2296
Query: 558 HNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRITPKFKSLSQT 617
NVF+ TYEG VDL+ + D E+ A+ I FGQTP QL PHP R++ ++
Sbjct: 2297 LNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQTPCQLLKEPHPTRLS------AEE 2350
Query: 618 SSYNASMADSPGEESFEDLTE----ESKTLAWNNITKLQLHEHYKIHKEAVTG-----IT 668
+++ + D+ F+ L E ++ ++ L L H + H G +T
Sbjct: 2351 AAHRLARLDTNSPSIFQHLDELKAFFAEVVSDGVPLVLALVPHRQPHSFITQGSPDLLVT 2410
Query: 669 VS--------------RNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPG 714
VS RN S+ F+ S+D T+ + + + S ++ + + P
Sbjct: 2411 VSASGLLGTHSWLPYDRNISNYFSFSKDPTMGSHKTQRLLSGPWVPGSGVSGQALAVAPD 2470
Query: 715 DATVITSS-WDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLY--SASWDSTVKVWS 771
+ + WD ++ ++ G+ L H D V+ + +Y S S D+T VW
Sbjct: 2471 GKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWR 2530
Query: 772 GVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNI 820
+ + H +V ++++ + VSG+++GTV I
Sbjct: 2531 LLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVII 2579
Score = 42.7 bits (99), Expect = 0.002
Identities = 32/113 (28%), Positives = 54/113 (47%), Gaps = 13/113 (11%)
Query: 843 AFSPDSRHVLSTGT-DGCLNVIDVQTGMLISSMTSD-EPQRCFVWD--GNSVLSGSQSGE 898
A +PD + + S G DG L V + G L+S ++ + C D G ++SGS+
Sbjct: 2466 AVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTT 2525
Query: 899 LLVWDLL---------GAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQII 942
+VW LL K + + GH AV+C+ ++ + ++G ED +I
Sbjct: 2526 CMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVI 2578
Score = 31.2 bits (69), Expect = 4.8
Identities = 18/62 (29%), Positives = 29/62 (46%), Gaps = 1/62 (1%)
Query: 886 DGNSVLSGSQ-SGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFW 944
DG + SG G L V L K+ ++ H VTC+ ++ +I+G D + W
Sbjct: 2470 DGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVW 2529
Query: 945 KL 946
+L
Sbjct: 2530 RL 2531
>gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 3526
Score = 294 bits (753), Expect = 2e-79
Identities = 231/717 (32%), Positives = 332/717 (46%), Gaps = 117/717 (16%)
Query: 269 QDVRRIYKRRHGLMPLGLEVF---------CTEDDLCSDIYLKFYE--PQDRDDLYFYIA 317
+D++ ++KRR+ L P+ +EVF + + + +Y +F P D
Sbjct: 2612 EDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAVVPSLTDSSESVSG 2671
Query: 318 TYLEHHVAEHTA--------ESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPW 369
V + + +S +W+RG +SN+QYL+HLN LA RS NDL QYPVFPW
Sbjct: 2672 QRPNTSVEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPW 2731
Query: 370 IIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEPK-----FMYGSHYS 424
I+ DY S E+DL+NP TFR+L+KP+GA ERL + RY++ +P + YG+HYS
Sbjct: 2732 ILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYS 2791
Query: 425 SPGYVLFYLVRIAP--EYMLCLQNGRFDNADRMFNSIAETWKNCLD-GATDFKELIPEFY 481
S V YLVR+ P + L LQ G FD ADRMF+S+ E W + D KELIPEF+
Sbjct: 2792 SAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIPEFF 2851
Query: 482 GDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASS-PEDFLQKSKDALESNYVSEHLHEW 540
FL NS DLG +Q G + DV LPPWA P +F++ ++ALE +YVS HLHEW
Sbjct: 2852 YLP-EFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEW 2910
Query: 541 IDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFV 600
IDLIFGYKQ+G AV A NVFH L YEG VD+ +I DP ++ A + I FGQ PKQLF
Sbjct: 2911 IDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFK 2970
Query: 601 TPHPRRITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYKIH 660
PHP PK + S+ + NA ++ PG S + L + +L E
Sbjct: 2971 KPHP----PK-RVRSRLNGDNAGISVLPGSTSDKIFFHHLDNLRPSLTPVKELKEPVGQI 3025
Query: 661 KEAVTGITVSRNGSSVFTTSQDSTLKM-FSKESKMLQRSISFSNMALSSCLLLPGDATVI 719
GI + + + T ++ S L S M + CL
Sbjct: 3026 VCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCRLGTYESDKAMTVYECL--------- 3076
Query: 720 TSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWS-GVPAEMP 778
S W + IC + + + + V VW G E
Sbjct: 3077 -SEWGQ---------------------ILCAICPNPKLVITGGTSTVVCVWEMGTSKEKA 3114
Query: 779 GTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGI 838
T LL H +V + + A ++VSG+++ T IWDL + + Q+ H
Sbjct: 3115 KTVTLKQALLG---HTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAP 3171
Query: 839 VCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVW--DGNSVLSGSQS 896
V C+N + TG ++S + VW +GN ++S
Sbjct: 3172 VSAL----------------CINEL---TGDIVSCAGT----YIHVWSINGNPIVS---- 3204
Query: 897 GELLVWDLLGAKISERIQGHTGAVTCIWMNEQ-----CSSIITGGEDRQIIFWKLQY 948
G + + C M+E + I+TG D + FW++++
Sbjct: 3205 -------------VNTFTGRSQQIICCCMSEMNEWDTQNVIVTGHSDGVVRFWRMEF 3248
>gi|191252801 WDFY family member 4 [Homo sapiens]
Length = 3184
Score = 273 bits (698), Expect = 6e-73
Identities = 215/681 (31%), Positives = 328/681 (48%), Gaps = 80/681 (11%)
Query: 270 DVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTA 329
D+R + + R L + LE+F +L FY DR + ++ + T+
Sbjct: 2467 DMRELRQARFLLQDIALEIFFHNG---YSKFLVFYN-NDRSKAFKSFCSFQPSLKGKATS 2522
Query: 330 ES------------YMLQ-WQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSS 376
E MLQ WQ+ +SN++YL++LN A R+CND QYPVFPW++ DY+S
Sbjct: 2523 EDTLSLRRYPGSDRIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTS 2582
Query: 377 SELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEPK------FMYGSHYSSPGYVL 430
L+L+NP FRDLSKP+GA KER + + R++E+ + + Y +HYSS V
Sbjct: 2583 ETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVA 2642
Query: 431 FYLVRIAP--EYMLCLQNGRFDNADRMFNSIAETWKNCL-DGATDFKELIPEFYGDDVSF 487
YLVR+ P + LQ G FD ADRMF+S+ TW++ + +D +EL PEF+ F
Sbjct: 2643 SYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLP-EF 2701
Query: 488 LVNSLKLDLGKRQGGQMVDDVELPPWASS-PEDFLQKSKDALESNYVSEHLHEWIDLIFG 546
L N ++ G Q G ++ DV+LPPWA P F+ + ALES++VS +LH WIDLIFG
Sbjct: 2702 LTNCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIFG 2761
Query: 547 YKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRR 606
YKQ+G AV A N+FHP Y +DL+SI DP K +L + FGQ PKQLF PHP R
Sbjct: 2762 YKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPAR 2821
Query: 607 ITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYKIHKEAVTG 666
+ S S+ P + F L ++L + +T ++ + + E
Sbjct: 2822 TAAGKPLPGKDVSTPVSLPGHP-QPFFYSL----QSLRPSQVTVKDMY-LFSLGSE---- 2871
Query: 667 ITVSRNGSSVFTTSQDSTLKMFSKESKML----QRSISFSNMALSSCLLLPGDATVITSS 722
S G+ S + T+ + +L R+ S+ S CL G V+ +
Sbjct: 2872 ---SPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWGFDDFSCCLGSYGSDKVLMT- 2927
Query: 723 WDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKR 782
+ A+GR + +C + ++ + V VW E+ TK
Sbjct: 2928 -----FENLAAWGR----------CLCAVCPSPTTIVTSGTSTVVCVW-----ELSMTKG 2967
Query: 783 HHFDL---LAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIV 839
L A H +V ++ + +LLVSG+++ T +WDL T + ++P H +
Sbjct: 2968 RPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGI 3027
Query: 840 CDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCF---------VWDGNS- 889
S S ++S L++ +V L S T+ P+ WD +
Sbjct: 3028 SAITISDVSGTIVSC-AGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQI 3086
Query: 890 VLSGSQSGELLVWDLLGAKIS 910
+++GSQ G + VW K+S
Sbjct: 3087 IITGSQDGMVRVWKTEDVKMS 3107
Score = 37.7 bits (86), Expect = 0.051
Identities = 18/67 (26%), Positives = 35/67 (52%), Gaps = 7/67 (10%)
Query: 889 SVLSGSQSGELLVWDLL-------GAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQI 941
++++ S + VW+L G ++ + + GHT AVTC+ + S +++G +D
Sbjct: 2947 TIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTC 3006
Query: 942 IFWKLQY 948
I W L +
Sbjct: 3007 ILWDLDH 3013
>gi|54292123 lysosomal trafficking regulator [Homo sapiens]
Length = 3801
Score = 252 bits (644), Expect = 1e-66
Identities = 225/783 (28%), Positives = 347/783 (44%), Gaps = 117/783 (14%)
Query: 222 SEKLHMECKAEMVTPLVTNPGHVCITDTNLYF-----------QPLNGYPKPV-VQITLQ 269
SE + + + V P G + + +YF L G +P T +
Sbjct: 3011 SESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVESSSLQGELEPASFSWTYE 3070
Query: 270 DVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTA 329
+++ ++KR L +E+F T + L F + RDD+Y I T ++ E+
Sbjct: 3071 EIKEVHKRWWQLRDNAVEIFLTNG---RTLLLAFDNTKVRDDVYHNILTNNLPNLLEYGN 3127
Query: 330 ESYMLQ-WQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPGTFR 388
+ + W G ++N++YL HLN A RS NDL QYPVFP+I+ DY S LDL++ +R
Sbjct: 3128 ITALTNLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYR 3187
Query: 389 DLSKPVGALNKERLERLLTRYQEM---------------PEPKFMYGSHYSSPGYVLFYL 433
+LSKP+ KE+ +R + Y+ + P + YGSHYS+ G VL +L
Sbjct: 3188 NLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFL 3247
Query: 434 VRIAP--EYMLCLQNGRFDNADRMFNSIAETWK-NCLDGATDFKELIPEFYGDDVSFLVN 490
VR+ P + L Q+ FD DR F+S TW+ + + TD KELIPEF+ FLVN
Sbjct: 3248 VRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLP-EFLVN 3306
Query: 491 SLKLDLGKRQGGQMVDDVELPPWA-SSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQ 549
D G RQ G+ V+ V LPPWA + P F+ + ALES+YVS+++ +WIDL+FGYKQ
Sbjct: 3307 REGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQ 3366
Query: 550 KGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRITP 609
KG +V A NVFHP TY G+D+++++DP ++ A+ T I +GQTP+QLF H R
Sbjct: 3367 KGKASVQAINVFHPATY-FGMDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGA 3425
Query: 610 KFK---SLSQTSSYNASMADSPGEESFEDLTEES-----KTLAWNN-----------ITK 650
K L A E +++T S K L W +
Sbjct: 3426 KLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCF 3485
Query: 651 LQLHEH-----YKIHKEAVTGITVSRNGSSVFTTSQ-----------------------D 682
Q H + A+ G+ SRN + T S+ D
Sbjct: 3486 SQPHGERFGSLQALPTRAICGL--SRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYAD 3543
Query: 683 STLKMFSKESKMLQRSISFSNM-ALSSCLLLPGDATVITSSWDNNVYFYSIAFG------ 735
+ L++ SK+S+ I S ++SC +P + T S + Y+ F
Sbjct: 3544 NILRLKSKQSEPPVNFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSE 3603
Query: 736 ---RRQDTLMGHDDAVSK--ICWHDNRLYSASWDSTVKVWS-GVPAEMPGTKRHHFDLLA 789
Q L GH + ++ +C + L S S D T +W + H + A
Sbjct: 3604 IEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTA 3663
Query: 790 ELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSR 849
+ S D +T+ S + +W + L+ + C I+C AFS
Sbjct: 3664 VSASETSGD------IATVCDSAGGGSDLRLWTV-NGDLVGHVHCRE-IICSVAFSNQPE 3715
Query: 850 HV--------LSTGTDGCLNVIDVQTGMLISSMTSDEP--QRCFVWDGNSVLSGSQSGEL 899
V L G + D++ I+ S++P F DG+ + + + G +
Sbjct: 3716 GVSINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTV 3775
Query: 900 LVW 902
+ W
Sbjct: 3776 IAW 3778
>gi|239756689 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 1941
Score = 104 bits (260), Expect = 3e-22
Identities = 87/286 (30%), Positives = 127/286 (44%), Gaps = 49/286 (17%)
Query: 331 SYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNP-GTFRD 389
S +L W G +SN+ YL+ LN LA R D + +PV PW++ D + P G FRD
Sbjct: 347 SLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV--------DFTTPHGRFRD 398
Query: 390 LSKPVGALNKERLERLLTRYQEMPEPKFMYG-SHYSSPGYVLFYLVRIAPEYMLCLQNGR 448
L K LNK ++ L EM F+ G + P +V ++ + + + R
Sbjct: 399 LRKSKFRLNKG--DKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKAR 456
Query: 449 FDNADRMFNSIAETWKNCLDGATDFK-------ELIPEFYGDDVSFLVNSLKLDLGKRQG 501
+ + W+ A+ + E IPEFY D F S+ D+
Sbjct: 457 RTPRSVLCGHVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIF--RSIHPDM----- 509
Query: 502 GQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVGAHNVF 561
D+++P W SS ++F+ + LES VS LH WIDL FGYK +G +AV NV
Sbjct: 510 ----PDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVC 565
Query: 562 HPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRI 607
L VD + T + +G QLF PHP+R+
Sbjct: 566 LHL-----VDAH------------THLASYGVV--QLFDQPHPQRL 592
Score = 35.8 bits (81), Expect = 0.19
Identities = 34/154 (22%), Positives = 64/154 (41%), Gaps = 14/154 (9%)
Query: 762 SWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTIS-LNAASTLLVSGTKEGTVNI 820
S D V VW + T + L+ V + ++ + A T + + + T+
Sbjct: 1714 SCDGAVHVWDPFTGKTLRT-------VEPLDSRVPLTAVAVMPAPHTSITMASSDSTLRF 1766
Query: 821 WDLTTATLMHQIPC----HSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTS 876
D L H+ + G+V A SP R V++ + G + ++D +TG+++ +
Sbjct: 1767 VDCRKPGLQHEFRLGGGLNPGLVRALAISPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPA 1826
Query: 877 DEPQ--RCFVWDGNSVLSGSQSGELLVWDLLGAK 908
E + +G+ ++S S L VW L K
Sbjct: 1827 HEGDILQIKAVEGSVLVSSSSDHSLTVWKELEQK 1860
>gi|239751186 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 2240
Score = 104 bits (260), Expect = 3e-22
Identities = 87/286 (30%), Positives = 127/286 (44%), Gaps = 49/286 (17%)
Query: 331 SYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNP-GTFRD 389
S +L W G +SN+ YL+ LN LA R D + +PV PW++ D + P G FRD
Sbjct: 646 SLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV--------DFTTPHGRFRD 697
Query: 390 LSKPVGALNKERLERLLTRYQEMPEPKFMYG-SHYSSPGYVLFYLVRIAPEYMLCLQNGR 448
L K LNK ++ L EM F+ G + P +V ++ + + + R
Sbjct: 698 LRKSKFRLNKG--DKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKAR 755
Query: 449 FDNADRMFNSIAETWKNCLDGATDFK-------ELIPEFYGDDVSFLVNSLKLDLGKRQG 501
+ + W+ A+ + E IPEFY D F S+ D+
Sbjct: 756 RTPRSVLCGHVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIF--RSIHPDM----- 808
Query: 502 GQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVGAHNVF 561
D+++P W SS ++F+ + LES VS LH WIDL FGYK +G +AV NV
Sbjct: 809 ----PDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVC 864
Query: 562 HPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRI 607
L VD + T + +G QLF PHP+R+
Sbjct: 865 LHL-----VDAH------------THLASYGVV--QLFDQPHPQRL 891
Score = 35.8 bits (81), Expect = 0.19
Identities = 34/154 (22%), Positives = 64/154 (41%), Gaps = 14/154 (9%)
Query: 762 SWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTIS-LNAASTLLVSGTKEGTVNI 820
S D V VW + T + L+ V + ++ + A T + + + T+
Sbjct: 2013 SCDGAVHVWDPFTGKTLRT-------VEPLDSRVPLTAVAVMPAPHTSITMASSDSTLRF 2065
Query: 821 WDLTTATLMHQIPC----HSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTS 876
D L H+ + G+V A SP R V++ + G + ++D +TG+++ +
Sbjct: 2066 VDCRKPGLQHEFRLGGGLNPGLVRALAISPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPA 2125
Query: 877 DEPQ--RCFVWDGNSVLSGSQSGELLVWDLLGAK 908
E + +G+ ++S S L VW L K
Sbjct: 2126 HEGDILQIKAVEGSVLVSSSSDHSLTVWKELEQK 2159
>gi|239745674 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 1941
Score = 104 bits (260), Expect = 3e-22
Identities = 87/286 (30%), Positives = 127/286 (44%), Gaps = 49/286 (17%)
Query: 331 SYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNP-GTFRD 389
S +L W G +SN+ YL+ LN LA R D + +PV PW++ D + P G FRD
Sbjct: 347 SLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV--------DFTTPHGRFRD 398
Query: 390 LSKPVGALNKERLERLLTRYQEMPEPKFMYG-SHYSSPGYVLFYLVRIAPEYMLCLQNGR 448
L K LNK ++ L EM F+ G + P +V ++ + + + R
Sbjct: 399 LRKSKFRLNKG--DKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKAR 456
Query: 449 FDNADRMFNSIAETWKNCLDGATDFK-------ELIPEFYGDDVSFLVNSLKLDLGKRQG 501
+ + W+ A+ + E IPEFY D F S+ D+
Sbjct: 457 RTPRSVLCGHVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIF--RSIHPDM----- 509
Query: 502 GQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVGAHNVF 561
D+++P W SS ++F+ + LES VS LH WIDL FGYK +G +AV NV
Sbjct: 510 ----PDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVC 565
Query: 562 HPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRI 607
L VD + T + +G QLF PHP+R+
Sbjct: 566 LHL-----VDAH------------THLASYGVV--QLFDQPHPQRL 592
Score = 35.8 bits (81), Expect = 0.19
Identities = 34/154 (22%), Positives = 64/154 (41%), Gaps = 14/154 (9%)
Query: 762 SWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTIS-LNAASTLLVSGTKEGTVNI 820
S D V VW + T + L+ V + ++ + A T + + + T+
Sbjct: 1714 SCDGAVHVWDPFTGKTLRT-------VEPLDSRVPLTAVAVMPAPHTSITMASSDSTLRF 1766
Query: 821 WDLTTATLMHQIPC----HSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTS 876
D L H+ + G+V A SP R V++ + G + ++D +TG+++ +
Sbjct: 1767 VDCRKPGLQHEFRLGGGLNPGLVRALAISPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPA 1826
Query: 877 DEPQ--RCFVWDGNSVLSGSQSGELLVWDLLGAK 908
E + +G+ ++S S L VW L K
Sbjct: 1827 HEGDILQIKAVEGSVLVSSSSDHSLTVWKELEQK 1860
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 102 bits (253), Expect = 2e-21
Identities = 71/267 (26%), Positives = 120/267 (44%), Gaps = 18/267 (6%)
Query: 690 KESKMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVS 749
K + L+ +++ A+SS P + +SS D + + G+ + T+ GH +S
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91
Query: 750 KICWHD--NRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAAST 807
+ W N L SAS D T+K+W + T + H + V + N S
Sbjct: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY---------VFCCNFNPQSN 142
Query: 808 LLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQT 867
L+VSG+ + +V IWD+ T + +P HS V F+ D ++S+ DG + D +
Sbjct: 143 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202
Query: 868 GMLISSMTSDE-PQRCFVW---DGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCI 923
G + ++ D+ P FV +G +L+ + L +WD K + GH CI
Sbjct: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262
Query: 924 WMNEQCSS---IITGGEDRQIIFWKLQ 947
+ N + I++G ED + W LQ
Sbjct: 263 FANFSVTGGKWIVSGSEDNLVYIWNLQ 289
Score = 92.0 bits (227), Expect = 2e-18
Identities = 67/297 (22%), Positives = 132/297 (44%), Gaps = 20/297 (6%)
Query: 660 HKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVI 719
H +AV+ + S NG + ++S D +K++ +++IS + +S ++
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 720 TSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWH--DNRLYSASWDSTVKVWSGVPAEM 777
++S D + + ++ G+ TL GH + V ++ N + S S+D +V++W +
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163
Query: 778 PGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQ-IPCHS 836
T H D V + N +L+VS + +G IWD + + I +
Sbjct: 164 LKTLPAHSD---------PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 837 GIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVW------DGNSV 890
V FSP+ +++L+ D L + D G + + T + ++ ++ G +
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
Query: 891 LSGSQSGELLVWDLLGAKISERIQGHTGAV--TCIWMNEQCSSIITGGEDRQIIFWK 945
+SGS+ + +W+L +I +++QGHT V T E + D+ I WK
Sbjct: 275 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 102 bits (253), Expect = 2e-21
Identities = 71/267 (26%), Positives = 120/267 (44%), Gaps = 18/267 (6%)
Query: 690 KESKMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVS 749
K + L+ +++ A+SS P + +SS D + + G+ + T+ GH +S
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91
Query: 750 KICWHD--NRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAAST 807
+ W N L SAS D T+K+W + T + H + V + N S
Sbjct: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY---------VFCCNFNPQSN 142
Query: 808 LLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQT 867
L+VSG+ + +V IWD+ T + +P HS V F+ D ++S+ DG + D +
Sbjct: 143 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202
Query: 868 GMLISSMTSDE-PQRCFVW---DGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCI 923
G + ++ D+ P FV +G +L+ + L +WD K + GH CI
Sbjct: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262
Query: 924 WMNEQCSS---IITGGEDRQIIFWKLQ 947
+ N + I++G ED + W LQ
Sbjct: 263 FANFSVTGGKWIVSGSEDNLVYIWNLQ 289
Score = 92.0 bits (227), Expect = 2e-18
Identities = 67/297 (22%), Positives = 132/297 (44%), Gaps = 20/297 (6%)
Query: 660 HKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVI 719
H +AV+ + S NG + ++S D +K++ +++IS + +S ++
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 720 TSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWH--DNRLYSASWDSTVKVWSGVPAEM 777
++S D + + ++ G+ TL GH + V ++ N + S S+D +V++W +
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163
Query: 778 PGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQ-IPCHS 836
T H D V + N +L+VS + +G IWD + + I +
Sbjct: 164 LKTLPAHSD---------PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 837 GIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVW------DGNSV 890
V FSP+ +++L+ D L + D G + + T + ++ ++ G +
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
Query: 891 LSGSQSGELLVWDLLGAKISERIQGHTGAV--TCIWMNEQCSSIITGGEDRQIIFWK 945
+SGS+ + +W+L +I +++QGHT V T E + D+ I WK
Sbjct: 275 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 94.4 bits (233), Expect = 5e-19
Identities = 66/252 (26%), Positives = 112/252 (44%), Gaps = 18/252 (7%)
Query: 705 ALSSCLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDN--RLYSAS 762
A+SS P + +SS D + + G+ + TL GH+ +S + W + RL SAS
Sbjct: 43 AVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSAS 102
Query: 763 WDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWD 822
D T+K+W + T + H + V + N S L++SG+ + TV IW+
Sbjct: 103 DDKTLKLWDVRSGKCLKTLKGHSNY---------VFCCNFNPPSNLIISGSFDETVKIWE 153
Query: 823 LTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDE-PQR 881
+ T + + HS V F+ ++S DG + D +G + ++ D+ P
Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213
Query: 882 CFVW---DGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSS---IITG 935
FV +G +L+ + L +WD + + GH CI+ N + I++G
Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 273
Query: 936 GEDRQIIFWKLQ 947
ED + W LQ
Sbjct: 274 SEDNLVYIWNLQ 285
Score = 93.6 bits (231), Expect = 8e-19
Identities = 66/272 (24%), Positives = 125/272 (45%), Gaps = 22/272 (8%)
Query: 660 HKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVI 719
H EAV+ + S NG + ++S D + ++ ++++ N+ +S + ++
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99
Query: 720 TSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWH----DNRLYSASWDSTVKVWSGVPA 775
++S D + + + G+ TL GH + V C + N + S S+D TVK+W
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYV--FCCNFNPPSNLIISGSFDETVKIWEVKTG 157
Query: 776 EMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTA-TLMHQIPC 834
+ T H D V + N + +L+VSG+ +G IWD + L +
Sbjct: 158 KCLKTLSAHSD---------PVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDD 208
Query: 835 HSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQR-CF-----VWDGN 888
+ V FSP+ +++L+ D L + D G + + T + ++ C V G
Sbjct: 209 DNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGK 268
Query: 889 SVLSGSQSGELLVWDLLGAKISERIQGHTGAV 920
++SGS+ + +W+L +I +++QGHT V
Sbjct: 269 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 300
Score = 52.4 bits (124), Expect = 2e-06
Identities = 44/237 (18%), Positives = 90/237 (37%), Gaps = 39/237 (16%)
Query: 660 HKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVI 719
H ++ + S + S + + S D TLK++ S +++ + + C P +I
Sbjct: 82 HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLII 141
Query: 720 TSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWH--DNRLYSASWDSTVKVWSGVPAEM 777
+ S+D V + + G+ TL H D VS + ++ + + S S+D ++W +
Sbjct: 142 SGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQC 201
Query: 778 PGT---------------KRHHFDLLAELEHDVSVDTISLN------------------- 803
T + L A L++ + + S
Sbjct: 202 LKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFAN 261
Query: 804 ---AASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTD 857
+VSG+++ V IW+L T ++ ++ H+ +V A P + S +
Sbjct: 262 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALE 318
Score = 43.9 bits (102), Expect = 7e-04
Identities = 32/150 (21%), Positives = 64/150 (42%), Gaps = 3/150 (2%)
Query: 801 SLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCL 860
S +A + L +S + + + + L + H+ V FSP+ + S+ D +
Sbjct: 6 SRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLI 65
Query: 861 NVIDVQTGMLISSMTSDEPQRCFV-W--DGNSVLSGSQSGELLVWDLLGAKISERIQGHT 917
+ G ++ + V W D + ++S S L +WD+ K + ++GH+
Sbjct: 66 IIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHS 125
Query: 918 GAVTCIWMNEQCSSIITGGEDRQIIFWKLQ 947
V C N + II+G D + W+++
Sbjct: 126 NYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 94.0 bits (232), Expect = 6e-19
Identities = 73/280 (26%), Positives = 129/280 (46%), Gaps = 23/280 (8%)
Query: 673 GSSVFTTSQDSTLKMFSKES-KMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYS 731
G+ + + S D+TLK++S + K L+ + + SS + D +I+ S D + ++
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR---DNIIISGSTDRTLKVWN 329
Query: 732 IAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAEL 791
G TL GH V + H+ R+ S S D+T++VW + H + +
Sbjct: 330 AETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 389
Query: 792 EHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHV 851
++D +VSG + V +WD T T +H + H+ V F D HV
Sbjct: 390 QYD-----------GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHV 436
Query: 852 LSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFV-WDGNSVLSGSQSGELLVWDLLGAKIS 910
+S D + V DV+TG I ++T + + N ++SG+ + +WD+ +
Sbjct: 437 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCL 496
Query: 911 ERIQG---HTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQ 947
+ +QG H AVTC+ N+ + +IT +D + W L+
Sbjct: 497 QTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLK 534
Score = 73.2 bits (178), Expect = 1e-12
Identities = 54/209 (25%), Positives = 92/209 (44%), Gaps = 17/209 (8%)
Query: 741 LMGHDD-AVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDT 799
L GHDD ++ + + NR+ S S D+T+KVWS V + T H +
Sbjct: 258 LKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGH-----------TGGV 306
Query: 800 ISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGC 859
S +++SG+ + T+ +W+ T +H + H+ V + V+S D
Sbjct: 307 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTV--RCMHLHEKRVVSGSRDAT 364
Query: 860 LNVIDVQTGMLISSMTSD-EPQRCFVWDGNSVLSGSQSGELLVWDLLGAKISERIQGHTG 918
L V D++TG + + RC +DG V+SG+ + VWD +QGHT
Sbjct: 365 LRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN 424
Query: 919 AVTCIWMNEQCSSIITGGEDRQIIFWKLQ 947
V + + +++G D I W ++
Sbjct: 425 RVYSLQFDG--IHVVSGSLDTSIRVWDVE 451
Score = 56.2 bits (134), Expect = 1e-07
Identities = 54/235 (22%), Positives = 99/235 (42%), Gaps = 36/235 (15%)
Query: 676 VFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYSIAFG 735
+ + S D TLK+++ E+ ++ + + + C+ L + V++ S D + + I G
Sbjct: 316 IISGSTDRTLKVWNAETGECIHTL-YGHTSTVRCMHLH-EKRVVSGSRDATLRVWDIETG 373
Query: 736 RRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDV 795
+ LMGH AV + + R+ S ++D VKVW T + H + + L+ D
Sbjct: 374 QCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDG 433
Query: 796 ------SVDTI-----------------------SLNAASTLLVSGTKEGTVNIWDLTTA 826
S+DT + +LVSG + TV IWD+ T
Sbjct: 434 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG 493
Query: 827 TLMHQIP---CHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDE 878
+ + H V T + V+++ DG + + D++TG I ++ + E
Sbjct: 494 QCLQTLQGPNKHQSAV--TCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLE 546
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 94.0 bits (232), Expect = 6e-19
Identities = 73/280 (26%), Positives = 129/280 (46%), Gaps = 23/280 (8%)
Query: 673 GSSVFTTSQDSTLKMFSKES-KMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYS 731
G+ + + S D+TLK++S + K L+ + + SS + D +I+ S D + ++
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR---DNIIISGSTDRTLKVWN 447
Query: 732 IAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAEL 791
G TL GH V + H+ R+ S S D+T++VW + H + +
Sbjct: 448 AETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507
Query: 792 EHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHV 851
++D +VSG + V +WD T T +H + H+ V F D HV
Sbjct: 508 QYD-----------GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHV 554
Query: 852 LSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFV-WDGNSVLSGSQSGELLVWDLLGAKIS 910
+S D + V DV+TG I ++T + + N ++SG+ + +WD+ +
Sbjct: 555 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCL 614
Query: 911 ERIQG---HTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQ 947
+ +QG H AVTC+ N+ + +IT +D + W L+
Sbjct: 615 QTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLK 652
Score = 73.2 bits (178), Expect = 1e-12
Identities = 54/209 (25%), Positives = 92/209 (44%), Gaps = 17/209 (8%)
Query: 741 LMGHDD-AVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDT 799
L GHDD ++ + + NR+ S S D+T+KVWS V + T H +
Sbjct: 376 LKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGH-----------TGGV 424
Query: 800 ISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGC 859
S +++SG+ + T+ +W+ T +H + H+ V + V+S D
Sbjct: 425 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTV--RCMHLHEKRVVSGSRDAT 482
Query: 860 LNVIDVQTGMLISSMTSD-EPQRCFVWDGNSVLSGSQSGELLVWDLLGAKISERIQGHTG 918
L V D++TG + + RC +DG V+SG+ + VWD +QGHT
Sbjct: 483 LRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN 542
Query: 919 AVTCIWMNEQCSSIITGGEDRQIIFWKLQ 947
V + + +++G D I W ++
Sbjct: 543 RVYSLQFDG--IHVVSGSLDTSIRVWDVE 569
Score = 56.2 bits (134), Expect = 1e-07
Identities = 54/235 (22%), Positives = 99/235 (42%), Gaps = 36/235 (15%)
Query: 676 VFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYSIAFG 735
+ + S D TLK+++ E+ ++ + + + C+ L + V++ S D + + I G
Sbjct: 434 IISGSTDRTLKVWNAETGECIHTL-YGHTSTVRCMHLH-EKRVVSGSRDATLRVWDIETG 491
Query: 736 RRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDV 795
+ LMGH AV + + R+ S ++D VKVW T + H + + L+ D
Sbjct: 492 QCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDG 551
Query: 796 ------SVDTI-----------------------SLNAASTLLVSGTKEGTVNIWDLTTA 826
S+DT + +LVSG + TV IWD+ T
Sbjct: 552 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG 611
Query: 827 TLMHQIP---CHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDE 878
+ + H V T + V+++ DG + + D++TG I ++ + E
Sbjct: 612 QCLQTLQGPNKHQSAV--TCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLE 664
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 94.0 bits (232), Expect = 6e-19
Identities = 73/280 (26%), Positives = 129/280 (46%), Gaps = 23/280 (8%)
Query: 673 GSSVFTTSQDSTLKMFSKES-KMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYS 731
G+ + + S D+TLK++S + K L+ + + SS + D +I+ S D + ++
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR---DNIIISGSTDRTLKVWN 367
Query: 732 IAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAEL 791
G TL GH V + H+ R+ S S D+T++VW + H + +
Sbjct: 368 AETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 427
Query: 792 EHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHV 851
++D +VSG + V +WD T T +H + H+ V F D HV
Sbjct: 428 QYD-----------GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHV 474
Query: 852 LSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFV-WDGNSVLSGSQSGELLVWDLLGAKIS 910
+S D + V DV+TG I ++T + + N ++SG+ + +WD+ +
Sbjct: 475 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCL 534
Query: 911 ERIQG---HTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQ 947
+ +QG H AVTC+ N+ + +IT +D + W L+
Sbjct: 535 QTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLK 572
Score = 73.2 bits (178), Expect = 1e-12
Identities = 54/209 (25%), Positives = 92/209 (44%), Gaps = 17/209 (8%)
Query: 741 LMGHDD-AVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDT 799
L GHDD ++ + + NR+ S S D+T+KVWS V + T H +
Sbjct: 296 LKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGH-----------TGGV 344
Query: 800 ISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGC 859
S +++SG+ + T+ +W+ T +H + H+ V + V+S D
Sbjct: 345 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTV--RCMHLHEKRVVSGSRDAT 402
Query: 860 LNVIDVQTGMLISSMTSD-EPQRCFVWDGNSVLSGSQSGELLVWDLLGAKISERIQGHTG 918
L V D++TG + + RC +DG V+SG+ + VWD +QGHT
Sbjct: 403 LRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN 462
Query: 919 AVTCIWMNEQCSSIITGGEDRQIIFWKLQ 947
V + + +++G D I W ++
Sbjct: 463 RVYSLQFDG--IHVVSGSLDTSIRVWDVE 489
Score = 56.2 bits (134), Expect = 1e-07
Identities = 54/235 (22%), Positives = 99/235 (42%), Gaps = 36/235 (15%)
Query: 676 VFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYSIAFG 735
+ + S D TLK+++ E+ ++ + + + C+ L + V++ S D + + I G
Sbjct: 354 IISGSTDRTLKVWNAETGECIHTL-YGHTSTVRCMHLH-EKRVVSGSRDATLRVWDIETG 411
Query: 736 RRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDV 795
+ LMGH AV + + R+ S ++D VKVW T + H + + L+ D
Sbjct: 412 QCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDG 471
Query: 796 ------SVDTI-----------------------SLNAASTLLVSGTKEGTVNIWDLTTA 826
S+DT + +LVSG + TV IWD+ T
Sbjct: 472 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG 531
Query: 827 TLMHQIP---CHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDE 878
+ + H V T + V+++ DG + + D++TG I ++ + E
Sbjct: 532 QCLQTLQGPNKHQSAV--TCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLE 584
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 94.0 bits (232), Expect = 6e-19
Identities = 68/311 (21%), Positives = 131/311 (42%), Gaps = 15/311 (4%)
Query: 643 LAWNNITKLQLHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKES-KMLQRSISF 701
L N+ L + K H +T + ++++GS T S D T K++ S + L
Sbjct: 74 LGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGH 133
Query: 702 SNMALSSCLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSA 761
N+ + P + T S+D +S+ G+ T GH + + ++ A
Sbjct: 134 RNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVA 193
Query: 762 --SWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVN 819
S D+T K+W E T R H + ++S N + +++G+ + TV
Sbjct: 194 TGSMDTTAKLWDIQNGEEVYTLRGH---------SAEIISLSFNTSGDRIITGSFDHTVV 244
Query: 820 IWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEP 879
+WD T ++ + H + +F+ D +L+ D + D G ++++T +
Sbjct: 245 VWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDD 304
Query: 880 Q---RCFVWDGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGG 936
+ CF + G + + S G ++ K +++GH G ++ I N Q + ++TG
Sbjct: 305 EILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGS 364
Query: 937 EDRQIIFWKLQ 947
D+ W Q
Sbjct: 365 SDKTARIWDAQ 375
Score = 88.2 bits (217), Expect = 3e-17
Identities = 66/292 (22%), Positives = 117/292 (40%), Gaps = 15/292 (5%)
Query: 660 HKEAVTGITVSRN-GSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATV 718
H+ V I + G + T S D T K++S E+ + + P V
Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLV 192
Query: 719 ITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDN--RLYSASWDSTVKVWSGVPAE 776
T S D + I G TL GH + + ++ + R+ + S+D TV VW
Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDA---- 248
Query: 777 MPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHS 836
T R L+ H + + S N +L+++G+ + T +WD T + + H
Sbjct: 249 --DTGRKVNILIG---HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHD 303
Query: 837 GIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRC---FVWDGNSVLSG 893
+ D+ F + + + DG + T I+ + E + F GN +L+G
Sbjct: 304 DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTG 363
Query: 894 SQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWK 945
S +WD + + ++GHT + N + + +ITG +D W+
Sbjct: 364 SSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 79.3 bits (194), Expect = 2e-14
Identities = 61/289 (21%), Positives = 123/289 (42%), Gaps = 20/289 (6%)
Query: 619 SYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYKIHKEAVTGITVSRNGSSVFT 678
++N D SF+ KT ++ + + ++ H + ++ + + V T
Sbjct: 141 AFNNPYGDKIATGSFD------KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVAT 194
Query: 679 TSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYSIAFGRRQ 738
S D+T K++ ++ ++ + + S +IT S+D+ V + GR+
Sbjct: 195 GSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV 254
Query: 739 DTLMGHDDAVSKIC--WHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVS 796
+ L+GH +S W + + + S D T K+W + T H D + + D +
Sbjct: 255 NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314
Query: 797 VDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGT 856
L+ + + +GT I+ T + ++ H G + +F+P H+L+ +
Sbjct: 315 ---------GKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSS 365
Query: 857 DGCLNVIDVQTGMLISSMT--SDEPQRC-FVWDGNSVLSGSQSGELLVW 902
D + D QTG + + +DE C F + GN V++GS+ +W
Sbjct: 366 DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 92.4 bits (228), Expect = 2e-18
Identities = 76/306 (24%), Positives = 123/306 (40%), Gaps = 24/306 (7%)
Query: 653 LHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKML-------QRSISFSNMA 705
L H+K H++AVT + S N + + S DS L ++ + + + +++ N +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 706 LSSCLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDS 765
S LL G W NV S F T+ C +AS D
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRS-----VHFCSDGQSFVTASDDK 125
Query: 766 TVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTT 825
TVKVW+ T R F L + +H V + L+VS + + TV +WD ++
Sbjct: 126 TVKVWA--------THRQKF-LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 176
Query: 826 ATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQ---RC 882
+H H G V F P + + G D + V DV+T L+
Sbjct: 177 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLS 236
Query: 883 FVWDGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQII 942
F GN +++ S L + DL+ ++ + GH G T + + +GG D Q++
Sbjct: 237 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVM 296
Query: 943 FWKLQY 948
WK +
Sbjct: 297 VWKSNF 302
Score = 36.6 bits (83), Expect = 0.11
Identities = 15/36 (41%), Positives = 25/36 (69%)
Query: 652 QLHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKM 687
+L +HY++H AV G++ +G+ + T S DSTLK+
Sbjct: 220 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 255
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 92.4 bits (228), Expect = 2e-18
Identities = 76/306 (24%), Positives = 123/306 (40%), Gaps = 24/306 (7%)
Query: 653 LHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKML-------QRSISFSNMA 705
L H+K H++AVT + S N + + S DS L ++ + + + +++ N +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 706 LSSCLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDS 765
S LL G W NV S F T+ C +AS D
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRS-----VHFCSDGQSFVTASDDK 125
Query: 766 TVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTT 825
TVKVW+ T R F L + +H V + L+VS + + TV +WD ++
Sbjct: 126 TVKVWA--------THRQKF-LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 176
Query: 826 ATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQ---RC 882
+H H G V F P + + G D + V DV+T L+
Sbjct: 177 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLS 236
Query: 883 FVWDGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQII 942
F GN +++ S L + DL+ ++ + GH G T + + +GG D Q++
Sbjct: 237 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVM 296
Query: 943 FWKLQY 948
WK +
Sbjct: 297 VWKSNF 302
Score = 36.6 bits (83), Expect = 0.11
Identities = 15/36 (41%), Positives = 25/36 (69%)
Query: 652 QLHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKM 687
+L +HY++H AV G++ +G+ + T S DSTLK+
Sbjct: 220 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 255
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 90.1 bits (222), Expect = 9e-18
Identities = 72/307 (23%), Positives = 127/307 (41%), Gaps = 60/307 (19%)
Query: 691 ESKMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSK 750
E +L+R A++S L P + T+SWD + ++ R +GH D V+
Sbjct: 6 EDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTS 65
Query: 751 ICW--HDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTL 808
+ + H N L SAS D TV++W +P + + A H V ++ +A
Sbjct: 66 VQFSPHGNLLASASRDRTVRLW------IPDKRGKFSEFKA---HTAPVRSVDFSADGQF 116
Query: 809 LVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTD----------- 857
L + +++ ++ +W + ++ + H+ V FSPD R ++S D
Sbjct: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 176
Query: 858 ----------GCLNVIDVQ-TGMLISSMTSDEPQRCFVWD-------------------- 886
G N +D +G I+S SD+ + VWD
Sbjct: 177 QCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVK--VWDVRVNKLLQHYQVHSGGVNCI 234
Query: 887 -----GNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQI 941
GN +++ S G L + DLL ++ +QGHTG V + ++ +GG D Q+
Sbjct: 235 SFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
Query: 942 IFWKLQY 948
+ W+ +
Sbjct: 295 LLWRTNF 301
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 84.7 bits (208), Expect = 4e-16
Identities = 95/403 (23%), Positives = 167/403 (41%), Gaps = 48/403 (11%)
Query: 587 QILEFGQTPKQLFVTPHPRRITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWN 646
++L+ P+ +F R +T SL S S+A SP + + ++ W+
Sbjct: 86 KVLDIIYQPQAIF---RVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
Query: 647 NITKLQLHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKES-KMLQRSISFSNMA 705
T+ H K H+ V I+ S +G + + ++ + ++ + K + R+++ +
Sbjct: 143 LSTETP-HFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKW 201
Query: 706 LSSCLLLPGDAT-----VITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWH-DNRLY 759
++ P A V +SS D +V + GR + L GH +V+ + W D LY
Sbjct: 202 ITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY 261
Query: 760 SASWDSTVKVW---SGV-----------------------------PAEMPGTKRHHFDL 787
SAS D T+KVW GV PAE +
Sbjct: 262 SASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGS 321
Query: 788 LAEL-EHDVSVDTISLNAASTLLVSGTKEGTVNIWD-LTTATLMHQIPCHSGIVCDTAFS 845
L EL E +S + LVSG+ + T+ +W + ++ H ++ FS
Sbjct: 322 LQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFS 381
Query: 846 PDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEP---QRCFVWDGNSVLSGSQSGELLVW 902
PDSR V S D + + D +TG ++S+ Q + D ++SGS L VW
Sbjct: 382 PDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
Query: 903 DLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWK 945
D+ K++ + GH V + + + +GG+D+ + W+
Sbjct: 442 DVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 79.3 bits (194), Expect = 2e-14
Identities = 43/158 (27%), Positives = 73/158 (46%), Gaps = 3/158 (1%)
Query: 793 HDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVL 852
H V+++ LN L+V+G++ G++ +WDL A ++ + H +C F P V
Sbjct: 62 HTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVA 121
Query: 853 STGTDGCLNVIDV-QTGMLISSMTSDEPQRC--FVWDGNSVLSGSQSGELLVWDLLGAKI 909
S D + + D+ + G + + RC F DG + S + + +WDL K+
Sbjct: 122 SGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKM 181
Query: 910 SERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQ 947
GHTG V + + + +G DR I FW L+
Sbjct: 182 MSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLE 219
Score = 56.2 bits (134), Expect = 1e-07
Identities = 52/255 (20%), Positives = 102/255 (40%), Gaps = 14/255 (5%)
Query: 689 SKESKMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAV 748
+K + LQ ++ ++ S L + T D V +SI +L GH V
Sbjct: 7 TKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPV 66
Query: 749 SKICWH--DNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAAS 806
+ + + + + S +++VW A++ L + H ++ ++ +
Sbjct: 67 ESVRLNTPEELIVAGSQSGSIRVWDLEAAKI---------LRTLMGHKANICSLDFHPYG 117
Query: 807 TLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQ 866
+ SG+++ + +WD+ + + HS V FSPD + + S D + + D+
Sbjct: 118 EFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLT 177
Query: 867 TGMLISSMTSDE-PQRCFVWDGNSVL--SGSQSGELLVWDLLGAKISERIQGHTGAVTCI 923
G ++S P + N L SGS + WDL ++ I+G G V +
Sbjct: 178 AGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSV 237
Query: 924 WMNEQCSSIITGGED 938
N + +G +D
Sbjct: 238 LFNPDGCCLYSGCQD 252
Score = 55.8 bits (133), Expect = 2e-07
Identities = 50/242 (20%), Positives = 99/242 (40%), Gaps = 15/242 (6%)
Query: 660 HKEAVTGITVSR-NGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATV 718
H V+ + + + +G + T D + ++S S++ + S L + +
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
Query: 719 ITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLY--SASWDSTVKVWSGVPAE 776
+ S ++ + + + TLMGH + + +H + S S D+ +K+W
Sbjct: 79 VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWD----- 133
Query: 777 MPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHS 836
R + H +V + + L S + TV +WDLT +M + P H+
Sbjct: 134 ----IRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189
Query: 837 GIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDE-PQRCFVW--DGNSVLSG 893
G V F P+ + S +D + D++ ++S + + P R ++ DG + SG
Sbjct: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249
Query: 894 SQ 895
Q
Sbjct: 250 CQ 251
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 79.0 bits (193), Expect = 2e-14
Identities = 67/334 (20%), Positives = 129/334 (38%), Gaps = 50/334 (14%)
Query: 660 HKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVI 719
H+ + +++S +G + T S+D T +++S + ++ C L D
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAF 71
Query: 720 TSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPG 779
T S D + + + G+ GH V++I +N+L+S+S+D T +VWS +M
Sbjct: 72 TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSR 131
Query: 780 TKRHHFDLLAELEHDVSVDTISL-----NAASTLLVSGTKEGTVNIWDLTTATLMHQIPC 834
R H + + L + D S AA LLV+G+ +GT +W + + +
Sbjct: 132 EFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRG 191
Query: 835 HSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTG--------------------MLISSM 874
H+G V + TD + D+ +G L+ S
Sbjct: 192 HTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSG 251
Query: 875 TSDEPQRCFVWD---------------------GNSVLSGSQSGELLVWDLLGAKISERI 913
++D +C++ D ++ +GS +D ++
Sbjct: 252 SADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVF 311
Query: 914 QGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQ 947
+GHT + CI ++ Q + T D + W ++
Sbjct: 312 RGHTFIINCIQVHGQV--LYTASHDGALRLWDVR 343
Score = 38.9 bits (89), Expect = 0.023
Identities = 39/210 (18%), Positives = 70/210 (33%), Gaps = 55/210 (26%)
Query: 792 EHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHV 851
+H ++ +SL+ L++G+++GT +W + H V ++
Sbjct: 13 DHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFT 72
Query: 852 LSTG---------TDGCLNVIDVQTGML---------ISSMTSDEPQRCF---------- 883
S T CL V T ++ + S + D R +
Sbjct: 73 CSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSRE 132
Query: 884 ---------------VWD------------GNSVLSGSQSGELLVWDLLGAKISERIQGH 916
WD G +++GS G VW + + ++GH
Sbjct: 133 FRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGH 192
Query: 917 TGAVTCIWMNEQCSSIITGGEDRQIIFWKL 946
TGAV C+ ++ + TG D I W +
Sbjct: 193 TGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
Score = 35.8 bits (81), Expect = 0.19
Identities = 35/170 (20%), Positives = 67/170 (39%), Gaps = 13/170 (7%)
Query: 654 HEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLP 713
H+ + H AV + + G + FT S D+T++ + S Q + + CL L
Sbjct: 186 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGE-QLRVFREHRGSVICLELV 244
Query: 714 GDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGV 773
+ V + S D V + G T H VS + +H L++ S D+ + +
Sbjct: 245 -NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQ 303
Query: 774 PAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDL 823
E+ R H ++ + +L + + +G + +WD+
Sbjct: 304 SGELRRVFRGHTFIIN-----------CIQVHGQVLYTASHDGALRLWDV 342
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 78.6 bits (192), Expect = 3e-14
Identities = 61/240 (25%), Positives = 104/240 (43%), Gaps = 12/240 (5%)
Query: 660 HKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVI 719
H V S +G + S D T++++ R + ++ + P +
Sbjct: 62 HTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLA 121
Query: 720 TSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHD--NRLYSASWDSTVKVWSGVPAEM 777
+ WD V + + G+ L+GH D++ + N L + SWDSTV +W +
Sbjct: 122 SGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD-LRMVT 180
Query: 778 PGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSG 837
P + H ++ + +A S LL SG+ + T++IW TT++L+ Q+ H
Sbjct: 181 PAVSHQALE-----GHSANISCLCYSA-SGLLASGSWDKTIHIWKPTTSSLLIQLKGHVT 234
Query: 838 IVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTS--DEPQRC-FVWDGNSVLSGS 894
V AFSPD + S G + V D TG + ++ D C F DG ++SG+
Sbjct: 235 WVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGA 294
Score = 57.0 bits (136), Expect = 8e-08
Identities = 50/236 (21%), Positives = 96/236 (40%), Gaps = 16/236 (6%)
Query: 627 SPGEESFEDLTEESKTLAWNNITKLQLHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLK 686
SP F + + W+ + + + K H+ +V ++ S + + + D +
Sbjct: 72 SPDGHLFASASCDCTVRLWD-VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVM 130
Query: 687 MFSKESKMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYSIAF---GRRQDTLMG 743
++ +S + R + ++ S P + T SWD+ V+ + + L G
Sbjct: 131 LWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEG 190
Query: 744 HDDAVSKICWHDNRLY-SASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVS-VDTIS 801
H +S +C+ + L S SWD T+ +W P T LL +L+ V+ V +I+
Sbjct: 191 HSANISCLCYSASGLLASGSWDKTIHIWK------PTTS----SLLIQLKGHVTWVKSIA 240
Query: 802 LNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTD 857
+ L S V +WD T + + + AF+PD + ++S D
Sbjct: 241 FSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
Score = 56.2 bits (134), Expect = 1e-07
Identities = 58/247 (23%), Positives = 102/247 (41%), Gaps = 18/247 (7%)
Query: 706 LSSCLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWH--DNRLY-SAS 762
++S P ++T S D VY + G+ L GH V K C D L+ SAS
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPV-KFCRFSPDGHLFASAS 82
Query: 763 WDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWD 822
D TV++W A+ L H SV+T+S + S L SG + V +WD
Sbjct: 83 CDCTVRLWDVARAKC---------LRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Query: 823 LTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQR- 881
+ + ++ + H + + FSP + + D +++ D++ S + E
Sbjct: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193
Query: 882 ---CFVWDGNSVL-SGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGE 937
C + + +L SGS + +W + + +++GH V I + + + G
Sbjct: 194 NISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGY 253
Query: 938 DRQIIFW 944
R + W
Sbjct: 254 SRMVKVW 260
Score = 55.1 bits (131), Expect = 3e-07
Identities = 32/116 (27%), Positives = 58/116 (50%), Gaps = 3/116 (2%)
Query: 835 HSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSM---TSDEPQRCFVWDGNSVL 891
H G V +AFSPD + +L+ DGC+ + ++G L+ + T F DG+
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 892 SGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQ 947
S S + +WD+ AK ++GH +V + + + +GG D++++ W +Q
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ 135
Score = 54.7 bits (130), Expect = 4e-07
Identities = 38/180 (21%), Positives = 77/180 (42%), Gaps = 8/180 (4%)
Query: 771 SGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMH 830
SGVPA + + F +H V++ + + +L++G+++G V W+ + L+
Sbjct: 3 SGVPATLAVRRVKFFG-----QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLW 57
Query: 831 QIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDE---PQRCFVWDG 887
++ H+G V FSPD S D + + DV + + + F D
Sbjct: 58 RLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDS 117
Query: 888 NSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQ 947
+ SG +++WD+ ++ + GH ++ + + + TG D + W L+
Sbjct: 118 RQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR 177
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 78.2 bits (191), Expect = 3e-14
Identities = 63/254 (24%), Positives = 99/254 (38%), Gaps = 17/254 (6%)
Query: 698 SISFSNMALSSCLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNR 757
+++ N + S LL G W NV S F T+ C
Sbjct: 25 AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRS-----VHFCSDGQS 79
Query: 758 LYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGT 817
+AS D TVKVW+ T R F L + +H V + L+VS + + T
Sbjct: 80 FVTASDDKTVKVWA--------THRQKF-LFSLSQHINWVRCAKFSPDGRLIVSASDDKT 130
Query: 818 VNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSD 877
V +WD ++ +H H G V F P + + G D + V DV+T L+
Sbjct: 131 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH 190
Query: 878 EPQ---RCFVWDGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIIT 934
F GN +++ S L + DL+ ++ + GH G T + + +
Sbjct: 191 SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFAS 250
Query: 935 GGEDRQIIFWKLQY 948
GG D Q++ WK +
Sbjct: 251 GGSDEQVMVWKSNF 264
Score = 70.5 bits (171), Expect = 7e-12
Identities = 56/248 (22%), Positives = 104/248 (41%), Gaps = 14/248 (5%)
Query: 660 HKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVI 719
HK+AVT + S +G + + S+D T++++ K + S + +
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81
Query: 720 TSSWDNNVYFYSIAFGRRQDTLMGHDDAV--SKICWHDNRLYSASWDSTVKVWSGVPAEM 777
T+S D V ++ + +L H + V +K + SAS D TVK+W E
Sbjct: 82 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 141
Query: 778 PGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSG 837
H + EH V + + + T + + + TV +WD+ T L+ HS
Sbjct: 142 V----HSY-----CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA 192
Query: 838 IVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQR---CFVWDGNSVLSGS 894
V +F P ++++ +D L ++D+ G L+ ++ + F G SG
Sbjct: 193 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 252
Query: 895 QSGELLVW 902
+++VW
Sbjct: 253 SDEQVMVW 260
Score = 36.6 bits (83), Expect = 0.11
Identities = 15/36 (41%), Positives = 25/36 (69%)
Query: 652 QLHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKM 687
+L +HY++H AV G++ +G+ + T S DSTLK+
Sbjct: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217
Score = 31.6 bits (70), Expect = 3.7
Identities = 13/46 (28%), Positives = 22/46 (47%)
Query: 899 LLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFW 944
L+VW + + R GH AVTC+ + + +G D+ + W
Sbjct: 5 LMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW 50
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 74.7 bits (182), Expect = 4e-13
Identities = 59/249 (23%), Positives = 110/249 (44%), Gaps = 5/249 (2%)
Query: 660 HKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVI 719
HK + + ++ G+ + + D T ++ + ++ F + A + + + T
Sbjct: 265 HKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHS-APALDVDWQSNNTFA 323
Query: 720 TSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHD--NRLYSASWDSTVKVWSGVPAEM 777
+ S D ++ + R T GH + V+ I W N L S S D T+K+WS
Sbjct: 324 SCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNC 383
Query: 778 PGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSG 837
+ H + ++ + + A+ +L S + + TV +WD+ +H + H
Sbjct: 384 VHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQE 443
Query: 838 IVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSM--TSDEPQRCFVWDGNSVLSGSQ 895
V AFSPD R++ S D C+++ + QTG L+ S T + C+ G+ V + +
Sbjct: 444 PVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASAS 503
Query: 896 SGELLVWDL 904
G + V DL
Sbjct: 504 DGSVCVLDL 512
Score = 38.9 bits (89), Expect = 0.023
Identities = 39/183 (21%), Positives = 66/183 (36%), Gaps = 20/183 (10%)
Query: 748 VSKICWHDNR--LYSASWDSTVKVWS--GVPAEMPGTKRHHFDLLAELEHDVSVDTISLN 803
V+ + W+ L + S+D ++W+ G A G +H + + N
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLG------------QHKGPIFALKWN 275
Query: 804 AASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVI 863
++S + T IWD T Q P HS D + ++ S TD C++V
Sbjct: 276 KKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFA-SCSTDMCIHVC 334
Query: 864 DVQTGMLISSMTSDEPQ-RCFVWD--GNSVLSGSQSGELLVWDLLGAKISERIQGHTGAV 920
+ I + + WD GN + S S L +W + +Q H +
Sbjct: 335 KLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEI 394
Query: 921 TCI 923
I
Sbjct: 395 YTI 397
Score = 35.4 bits (80), Expect = 0.25
Identities = 34/152 (22%), Positives = 63/152 (41%), Gaps = 26/152 (17%)
Query: 793 HDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVL 852
H+ V + N S LL SG+ + T IW+L+ + SG + RH +
Sbjct: 168 HESEVFICAWNPVSDLLASGSGDSTARIWNLSENST-------SG-----STQLVLRHCI 215
Query: 853 STGTDGCLNVIDVQTGMLISSMTSDEPQRCFVWDGNSVLSGSQSGELLVWDLLGAKISER 912
G DV + ++S+ + +G + +GS G +W G ++
Sbjct: 216 REGGQ------DVPSNKDVTSLDWNS-------EGTLLATGSYDGFARIWTKDG-NLAST 261
Query: 913 IQGHTGAVTCIWMNEQCSSIITGGEDRQIIFW 944
+ H G + + N++ + I++ G D+ I W
Sbjct: 262 LGQHKGPIFALKWNKKGNFILSAGVDKTTIIW 293
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,006,014
Number of Sequences: 37866
Number of extensions: 1754996
Number of successful extensions: 6671
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 4584
Number of HSP's gapped (non-prelim): 1188
length of query: 948
length of database: 18,247,518
effective HSP length: 112
effective length of query: 836
effective length of database: 14,006,526
effective search space: 11709455736
effective search space used: 11709455736
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.