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Search of human proteins with 221307473
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH
domain 3 isoform b [Homo sapiens]
(894 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 1798 0.0
gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain... 1775 0.0
gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain ... 743 0.0
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 739 0.0
gi|46094081 development and differentiation enhancing factor 1 [... 710 0.0
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 179 1e-44
gi|187608516 centaurin, beta 2 [Homo sapiens] 177 3e-44
gi|7661880 centaurin beta1 [Homo sapiens] 171 4e-42
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 129 1e-29
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 129 1e-29
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 119 1e-26
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 118 3e-26
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 118 3e-26
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 118 3e-26
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 117 6e-26
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 115 1e-25
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 114 5e-25
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 111 3e-24
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 111 3e-24
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 111 3e-24
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 111 3e-24
gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 93 1e-18
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 91 6e-18
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 91 6e-18
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 81 5e-15
gi|6806913 centaurin, alpha 1 [Homo sapiens] 79 2e-14
gi|113204622 stromal membrane-associated GTPase-activating prote... 77 5e-14
gi|21264558 stromal membrane-associated GTPase-activating protei... 77 5e-14
gi|23943872 small ArfGAP2 [Homo sapiens] 73 1e-12
gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 73 1e-12
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 1798 bits (4656), Expect = 0.0
Identities = 894/894 (100%), Positives = 894/894 (100%)
Query: 1 MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVR 60
MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVR
Sbjct: 1 MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVR 60
Query: 61 AIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNL 120
AIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNL
Sbjct: 61 AIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNL 120
Query: 121 NNIVSFPLDSLMKGQLRDGRQASLSLGSRAKLEKERDRARVTGGIPGEVAQDMQRERRIF 180
NNIVSFPLDSLMKGQLRDGRQASLSLGSRAKLEKERDRARVTGGIPGEVAQDMQRERRIF
Sbjct: 121 NNIVSFPLDSLMKGQLRDGRQASLSLGSRAKLEKERDRARVTGGIPGEVAQDMQRERRIF 180
Query: 181 QLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLFPFIEKLAASVHA 240
QLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLFPFIEKLAASVHA
Sbjct: 181 QLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLFPFIEKLAASVHA 240
Query: 241 LHQAQEDELQKLTQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQHQGNKQFGTEKVGFL 300
LHQAQEDELQKLTQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQHQGNKQFGTEKVGFL
Sbjct: 241 LHQAQEDELQKLTQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQHQGNKQFGTEKVGFL 300
Query: 301 YKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVRPNPEEKKCFDLVTHN 360
YKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVRPNPEEKKCFDLVTHN
Sbjct: 301 YKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVRPNPEEKKCFDLVTHN 360
Query: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI
Sbjct: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
Query: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS
Sbjct: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
Query: 481 ELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCTPEPQ 540
ELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCTPEPQ
Sbjct: 481 ELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCTPEPQ 540
Query: 541 RLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPLVDFII 600
RLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPLVDFII
Sbjct: 541 RLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPLVDFII 600
Query: 601 QNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIARKKHHKE 660
QNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIARKKHHKE
Sbjct: 601 QNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIARKKHHKE 660
Query: 661 CEELLEQAQAGTFAFPLHVDYSWVISTEPGSDSEEDEEEKRCLLKLPAQAHWASGRLDIS 720
CEELLEQAQAGTFAFPLHVDYSWVISTEPGSDSEEDEEEKRCLLKLPAQAHWASGRLDIS
Sbjct: 661 CEELLEQAQAGTFAFPLHVDYSWVISTEPGSDSEEDEEEKRCLLKLPAQAHWASGRLDIS 720
Query: 721 NKTYETVASLGAATPQGESEDCPPPLPVKNSSRTLVQGCARHASGDRSEVSSLSSEAPET 780
NKTYETVASLGAATPQGESEDCPPPLPVKNSSRTLVQGCARHASGDRSEVSSLSSEAPET
Sbjct: 721 NKTYETVASLGAATPQGESEDCPPPLPVKNSSRTLVQGCARHASGDRSEVSSLSSEAPET 780
Query: 781 PESLGSPASSSSLMSPLEPGDPSQAPPNSEEGLREPPGTSRPSLTSGTTPSEMYLPVRFS 840
PESLGSPASSSSLMSPLEPGDPSQAPPNSEEGLREPPGTSRPSLTSGTTPSEMYLPVRFS
Sbjct: 781 PESLGSPASSSSLMSPLEPGDPSQAPPNSEEGLREPPGTSRPSLTSGTTPSEMYLPVRFS 840
Query: 841 SESTRSYRRGARSPEDGPSARQPLPRRNVPVGITEGDGSRTGSLPASSVQLLQD 894
SESTRSYRRGARSPEDGPSARQPLPRRNVPVGITEGDGSRTGSLPASSVQLLQD
Sbjct: 841 SESTRSYRRGARSPEDGPSARQPLPRRNVPVGITEGDGSRTGSLPASSVQLLQD 894
>gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform a [Homo sapiens]
Length = 903
Score = 1775 bits (4598), Expect = 0.0
Identities = 887/903 (98%), Positives = 887/903 (98%), Gaps = 9/903 (0%)
Query: 1 MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVR 60
MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVR
Sbjct: 1 MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVR 60
Query: 61 AIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNL 120
AIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNL
Sbjct: 61 AIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNL 120
Query: 121 NNIVSFPLDSLMKGQLRDGRQASLSL---------GSRAKLEKERDRARVTGGIPGEVAQ 171
NNIVSFPLDSLMKGQLRDGRQ S AKLEKERDRARVTGGIPGEVAQ
Sbjct: 121 NNIVSFPLDSLMKGQLRDGRQDSKKQLEKAWKDYEAKMAKLEKERDRARVTGGIPGEVAQ 180
Query: 172 DMQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLFPFI 231
DMQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLFPFI
Sbjct: 181 DMQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLFPFI 240
Query: 232 EKLAASVHALHQAQEDELQKLTQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQHQGNKQ 291
EKLAASVHALHQAQEDELQKLTQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQHQGNKQ
Sbjct: 241 EKLAASVHALHQAQEDELQKLTQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQHQGNKQ 300
Query: 292 FGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVRPNPEEK 351
FGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVRPNPEEK
Sbjct: 301 FGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVRPNPEEK 360
Query: 352 KCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGE 411
KCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGE
Sbjct: 361 KCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGE 420
Query: 412 PHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQS 471
PHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQS
Sbjct: 421 PHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQS 480
Query: 472 LTLDLLGPSELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRF 531
LTLDLLGPSELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRF
Sbjct: 481 LTLDLLGPSELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRF 540
Query: 532 ARRCTPEPQRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQA 591
ARRCTPEPQRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQA
Sbjct: 541 ARRCTPEPQRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQA 600
Query: 592 SLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALD 651
SLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALD
Sbjct: 601 SLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALD 660
Query: 652 IARKKHHKECEELLEQAQAGTFAFPLHVDYSWVISTEPGSDSEEDEEEKRCLLKLPAQAH 711
IARKKHHKECEELLEQAQAGTFAFPLHVDYSWVISTEPGSDSEEDEEEKRCLLKLPAQAH
Sbjct: 661 IARKKHHKECEELLEQAQAGTFAFPLHVDYSWVISTEPGSDSEEDEEEKRCLLKLPAQAH 720
Query: 712 WASGRLDISNKTYETVASLGAATPQGESEDCPPPLPVKNSSRTLVQGCARHASGDRSEVS 771
WASGRLDISNKTYETVASLGAATPQGESEDCPPPLPVKNSSRTLVQGCARHASGDRSEVS
Sbjct: 721 WASGRLDISNKTYETVASLGAATPQGESEDCPPPLPVKNSSRTLVQGCARHASGDRSEVS 780
Query: 772 SLSSEAPETPESLGSPASSSSLMSPLEPGDPSQAPPNSEEGLREPPGTSRPSLTSGTTPS 831
SLSSEAPETPESLGSPASSSSLMSPLEPGDPSQAPPNSEEGLREPPGTSRPSLTSGTTPS
Sbjct: 781 SLSSEAPETPESLGSPASSSSLMSPLEPGDPSQAPPNSEEGLREPPGTSRPSLTSGTTPS 840
Query: 832 EMYLPVRFSSESTRSYRRGARSPEDGPSARQPLPRRNVPVGITEGDGSRTGSLPASSVQL 891
EMYLPVRFSSESTRSYRRGARSPEDGPSARQPLPRRNVPVGITEGDGSRTGSLPASSVQL
Sbjct: 841 EMYLPVRFSSESTRSYRRGARSPEDGPSARQPLPRRNVPVGITEGDGSRTGSLPASSVQL 900
Query: 892 LQD 894
LQD
Sbjct: 901 LQD 903
>gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform a [Homo sapiens]
Length = 1006
Score = 743 bits (1919), Expect = 0.0
Identities = 425/954 (44%), Positives = 578/954 (60%), Gaps = 85/954 (8%)
Query: 1 MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVR 60
MP+Q SV+EF+A T ED +P A++F + + R A EE L+ D+ +L ++KK+V+
Sbjct: 1 MPDQISVSEFVAETHEDYKAPT-ASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVK 59
Query: 61 AIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNL 120
AI+SSGL HVENEEQY +A+E G + + ++ +L + FL +VFT+E+ ALFKNLIQN+
Sbjct: 60 AINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNM 119
Query: 121 NNIVSFPLDSLMKGQLRDGRQASLSLGSRA---------KLEKER-DRARVTGGIP---- 166
NNI+SFPLDSL+KG L+ + +A K+EKE+ + A++ G I
Sbjct: 120 NNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEIS 179
Query: 167 -GEVAQDMQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQ 225
E+A++M++ERR FQL MCEYLLK E ++K+G D LQ+LIK+FHAQ NFFQDG KA +
Sbjct: 180 GAEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVE 239
Query: 226 SLFPFIEKLAASVHALHQAQEDELQKLTQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQ 285
SL P IE L+ +H + QAQ++E ++L QLRD L+ LQ+E +E+ R+++ YS+HQ
Sbjct: 240 SLKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTA--YSLHQ 297
Query: 286 HQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVR 345
QGNK+ GTE+ G LYKKSDGIR+VWQKRKC VK G LTISH T NRPP KL LLTCQV+
Sbjct: 298 PQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVK 357
Query: 346 PNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGS 405
NPEEKKCFDL++H+RTYHFQAEDE EC+ W+SVLQNSK+EAL++AF G+ +
Sbjct: 358 TNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGD--------DN 409
Query: 406 AGHDGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVR 465
G + +LTK +I+EV+ GN CCDCGA DPTWLSTNLG+LTCI+CSG+HRELGV
Sbjct: 410 TGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVH 469
Query: 466 FSRMQSLTLDLLGPSELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAK 525
+SRMQSLTLD+LG SELLLA N+GN FNE+ME LP+ KP+ SDM R+DYI AK
Sbjct: 470 YSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAK 529
Query: 526 YVEHRFARR----CTPEPQRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVL 581
Y+E R+AR+ + L A+ RD+ +L+A+A+G D + +P + P+E L
Sbjct: 530 YIERRYARKKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETAL 589
Query: 582 HLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGT 641
HLAV+ ++ SL +VDF++QN G+LD + G+TALHY L + +CLKLLL+G+A +
Sbjct: 590 HLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEI 649
Query: 642 VNEAGETALDIARKKHHKECEELLEQAQAGTFAFPLHVDYSWVISTEPGSDSEEDEEEK- 700
NE+GET LDIA++ H+ CEELL QA +G F +HV+Y W + E +S++D +EK
Sbjct: 650 ANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKL 709
Query: 701 ------------------------------RCLLKLPAQAHWASGRLDISNKTYETV--A 728
R L + A + N+TY +
Sbjct: 710 QPSPNRREDRPISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSG 769
Query: 729 SLGAATPQGESEDCPPPLPVKNSSRTLVQGCA------RHASGDRSEVSSLSSEAPETPE 782
S A P S PPLP +N + A S D SS+ P
Sbjct: 770 SPPPAQPAAPSTTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHP 829
Query: 783 SLGSPASSSSLMSPLEPGDPSQA--PPNSEEGLREPPGTSRPSLTSGTTPSEMYLPVRFS 840
L P + +PL P P P+ E L +P + P ++ P LP +
Sbjct: 830 PL--PPLRVTSTNPLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPP---LPPQPP 884
Query: 841 SESTRSYRRGARSPEDGPSARQPLPRRNVPVGITEGDGSRTGSL-PASSVQLLQ 893
S R + P G PL + P G D S T +L P S+ +LQ
Sbjct: 885 S------RLPQKKPAPGADKSTPLTNKGQPRGPV--DLSATEALGPLSNAMVLQ 930
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 739 bits (1909), Expect = 0.0
Identities = 418/916 (45%), Positives = 575/916 (62%), Gaps = 54/916 (5%)
Query: 1 MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVR 60
MP+Q SV+EF+A T ED +P A++F + + R A EE L+ D+ +L ++KK+V+
Sbjct: 1 MPDQISVSEFVAETHEDYKAPT-ASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVK 59
Query: 61 AIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNL 120
AI+SSGL HVENEEQY +A+E G + + ++ +L + FL +VFT+E+ ALFKNLIQN+
Sbjct: 60 AINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNM 119
Query: 121 NNIVSFPLDSLMKGQLRDGRQASLSLGSRA---------KLEKER-DRARVTGGIP---- 166
NNI+SFPLDSL+KG L+ + +A K+EKE+ + A++ G I
Sbjct: 120 NNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEIS 179
Query: 167 -GEVAQDMQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQ 225
E+A++M++ERR FQL MCEYLLK E ++K+G D LQ+LIK+FHAQ NFFQDG KA +
Sbjct: 180 GAEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVE 239
Query: 226 SLFPFIEKLAASVHALHQAQEDELQKLTQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQ 285
SL P IE L+ +H + QAQ++E ++L QLRD L+ LQ+E +E+ R+++ YS+HQ
Sbjct: 240 SLKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTA--YSLHQ 297
Query: 286 HQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVR 345
QGNK+ GTE+ G LYKKSDGIR+VWQKRKC VK G LTISH T NRPP KL LLTCQV+
Sbjct: 298 PQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVK 357
Query: 346 PNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGS 405
NPEEKKCFDL++H+RTYHFQAEDE EC+ W+SVLQNSK+EAL++AF G+ +
Sbjct: 358 TNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGD--------DN 409
Query: 406 AGHDGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVR 465
G + +LTK +I+EV+ GN CCDCGA DPTWLSTNLG+LTCI+CSG+HRELGV
Sbjct: 410 TGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVH 469
Query: 466 FSRMQSLTLDLLGPSELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAK 525
+SRMQSLTLD+LG SELLLA N+GN FNE+ME LP+ KP+ SDM R+DYI AK
Sbjct: 470 YSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAK 529
Query: 526 YVEHRFARR----CTPEPQRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVL 581
Y+E R+AR+ + L A+ RD+ +L+A+A+G D + +P + P+E L
Sbjct: 530 YIERRYARKKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETAL 589
Query: 582 HLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGT 641
HLAV+ ++ SL +VDF++QN G+LD + G+TALHY L + +CLKLLL+G+A +
Sbjct: 590 HLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEI 649
Query: 642 VNEAGETALDIARKKHHKECEELLEQAQAGTFAFPLHVDYSWVISTEPGSDSEEDEEEKR 701
NE+GET LDIA++ H+ CEELL QA +G F +HV+Y W + E +S++D +EK
Sbjct: 650 ANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKL 709
Query: 702 CLLKLPAQAHWASGRLDISNKTYETVASLG--AATPQGESEDCPPPLPVKNSS-RTLVQG 758
+ S SN+ SL AA E + P ++N + L+ G
Sbjct: 710 QPSPNRREDRPISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSG 769
Query: 759 CARHASGDRSEVSSLSSEAPETPESLGSPASSSSLMSPLEPGDPSQAPPNSEEGLREPPG 818
A + S +S P P ++G + + P P P+ E L +P
Sbjct: 770 SPPPA---QPAAPSTTSAPPLPPRNVGKDPLTPT------PPPPVAKTPSVMEALSQPSK 820
Query: 819 TSRPSLTSGTTPSEMYLPVRFSSESTRSYRRGARSPEDGPSARQPLPRRNVPVGITEGDG 878
+ P ++ P LP + S R + P G PL + P G D
Sbjct: 821 PAPPGISQIRPPP---LPPQPPS------RLPQKKPAPGADKSTPLTNKGQPRGPV--DL 869
Query: 879 SRTGSL-PASSVQLLQ 893
S T +L P S+ +LQ
Sbjct: 870 SATEALGPLSNAMVLQ 885
>gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
Length = 1129
Score = 710 bits (1833), Expect = 0.0
Identities = 399/879 (45%), Positives = 561/879 (63%), Gaps = 69/879 (7%)
Query: 1 MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVR 60
MP+Q SV+EF+A T ED +SP ++F ++ R EE L+ D+ LQ++KK+V+
Sbjct: 21 MPDQISVSEFIAETTEDYNSPT-TSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVK 79
Query: 61 AIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNL 120
AI++SG HV+NEE Y + ++ G++ LS+++ +L T F+ + T+E++ L KNL+Q L
Sbjct: 80 AIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGL 139
Query: 121 NNIVSFPLDSLMKGQLRDGRQASLSLGSRA---------KLEKE-RDRARVTGGIP---- 166
++ V F LDSL+KG L+ + +A K+EKE R+ A+ G I
Sbjct: 140 SHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEIT 199
Query: 167 -GEVAQDMQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQ 225
E+A++M++ERR+FQL MCEYL+K E + K+G D LQ+LIK++HAQ NFFQDG K A
Sbjct: 200 GAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTAD 259
Query: 226 SLFPFIEKLAASVHALHQAQEDELQKLTQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQ 285
L +IEKLAA ++ + Q Q++E ++LT LRD ++ +LQL+ +E+ SR+ GYS+HQ
Sbjct: 260 KLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQG---GYSMHQ 316
Query: 286 HQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVR 345
QGNK++G+EK G+L KKSDGIR+VWQ+RKC VK G LTISH+T NR P KL LLTCQV+
Sbjct: 317 LQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVK 376
Query: 346 PNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGS 405
PN E+KK FDL++HNRTYHFQAEDE + AW+SVL NSK+EAL+ AF GE SAG S
Sbjct: 377 PNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSL-- 434
Query: 406 AGHDGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVR 465
DLTK +I +V+ PGN CCDCG+++PTWLSTNLG+LTCI+CSG+HRE+GV
Sbjct: 435 -------EDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVH 487
Query: 466 FSRMQSLTLDLLGPSELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAK 525
SR+QSL LD LG SELLLA N+GN SFN++MEA LPS PKP+ SDM R++YI AK
Sbjct: 488 ISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPS-PSPKPTPSSDMTVRKEYITAK 546
Query: 526 YVEHRFARR-CTPEPQR---LWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVL 581
YV+HRF+R+ C+ + L AI +RDLL++++ +A G + +PL P Q E L
Sbjct: 547 YVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETAL 605
Query: 582 HLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGT 641
HLAV+ A+Q SL LVDF++QN G+LD + A GNT LHY ++Y++P+CLKLLL+ + V
Sbjct: 606 HLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDI 665
Query: 642 VNEAGETALDIARKKHHKECEELLEQAQAGTFAFPLHVDYSWVISTEPGSDSEEDEEEKR 701
VN+AGETALDIA++ +CE+LL QA++G F +HV+Y W + E +S++D ++K
Sbjct: 666 VNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKP 725
Query: 702 CLLKLPAQAHWASGRLDISNKTYETVASLGAATPQGE----------------SEDCP-- 743
+K S S + +A G +TP+ + S D P
Sbjct: 726 SPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTS 785
Query: 744 -----PPLPVKNSSR--TLVQGCARHASGDRSEVSSLSSEAPETPESLGSPASSSSLMSP 796
PPLP +N+ + T ++ S S+LS + P P G + S SP
Sbjct: 786 PTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPP-GHKRTLSDPPSP 844
Query: 797 LEPGDPSQ---------APPNSEEGLREPPGTSRPSLTS 826
L G P++ P +S + + G S+ S TS
Sbjct: 845 LPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTS 883
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 179 bits (453), Expect = 1e-44
Identities = 145/524 (27%), Positives = 229/524 (43%), Gaps = 27/524 (5%)
Query: 32 PRYRGAALAREEILEGDQAILQRIKKAVRAIHSSGLGHVENEEQYREAVESLGNSHLSQN 91
PR+R E + +A L ++ K + +G +V + V L S Q
Sbjct: 13 PRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDL--SQQCQG 70
Query: 92 SHELSTGFLNLAVFTREVAALFKNLIQNLNNIVSFPLDSLMKGQLRDGRQASLSLGS-RA 150
+S A +EV L V L S +K +R ++ R
Sbjct: 71 DTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKETKKQFDKVRE 130
Query: 151 KLEKERDR-ARVTGGIPGEVAQD---MQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSL 206
LE R A+ P EV + + R+ F+ +Y+L+ Q K+ + L S+
Sbjct: 131 DLELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQAKKKFEILDSM 190
Query: 207 IKFFHAQHNFFQDGWKAAQSLFPFIEKLAASVHALHQAQEDELQKLTQLRDSLRGTLQLE 266
+ F HAQ +FFQ G+ L P+++KLAA + L E +++ + +Q
Sbjct: 191 LSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREM----ERKHAAIQQR 246
Query: 267 SREEHLSRKNSGCGYSIHQHQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTIS 326
+ + S S + + + G G+L+K++ + W +R ++ L
Sbjct: 247 TLLQDFSYDESKVEFDV-----DAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQ 301
Query: 327 HSTINRPPVKLT-LLTCQVRP--NPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQ-- 381
+ V + L C V+P + E + CF++++ ++ QA+ E +AWV +Q
Sbjct: 302 KKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQAS 361
Query: 382 ------NSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLIAEVKSRPGNSQCCDC 435
S D S S S SA E + ++ V+S GNSQC DC
Sbjct: 362 IASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDC 421
Query: 436 GAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPSELLLALNMGNTSFNE 495
G DP W S NLGVL CI+CSG+HR LGV S+++SLTLD P L L +GN++ N+
Sbjct: 422 GQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQ 481
Query: 496 VMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCTPEP 539
+ EAQ G KP+A S + +I KYVE +F R+ P
Sbjct: 482 IYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAPMAP 525
Score = 34.7 bits (78), Expect = 0.41
Identities = 29/121 (23%), Positives = 54/121 (44%), Gaps = 7/121 (5%)
Query: 549 RDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPLVDFIIQNGGHLDA 608
RDL ++ A A+G + + + P V+ SL + +F++QNG ++
Sbjct: 679 RDLPALAAALAHGAEVNWADAEDEGKTP-------LVQAVLGGSLIVCEFLLQNGADVNQ 731
Query: 609 KAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIARKKHHKECEELLEQA 668
+ + G LH+A L + + L LK A +++ L IA + + + LL A
Sbjct: 732 RDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTLLRLA 791
Query: 669 Q 669
+
Sbjct: 792 R 792
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 177 bits (450), Expect = 3e-44
Identities = 143/559 (25%), Positives = 245/559 (43%), Gaps = 55/559 (9%)
Query: 32 PRYRGAALAREEILEGDQAILQ----RIKKAVRAIHSSGLGHVENEEQYREAVESLGNSH 87
PR+R A E +EGD A L+ ++ K A+ +G +Q+ + L +
Sbjct: 15 PRFRAAL----EEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDL--AQ 68
Query: 88 LSQNSHELSTGFLNLAVFTREVAALFKNLIQNLNNIVSFPLDSLMKGQLRDGRQASLSLG 147
S N + T + +E+ L + L + +K LR + A
Sbjct: 69 YSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDAKKQF- 127
Query: 148 SRAKLEKERDRARVTGGIPGEVAQDMQRE-----------RRIFQLHMCEYLLKAGESQM 196
K+ +E++ A V +V ++ Q E R+ F+ +Y+L+ Q
Sbjct: 128 --EKVSEEKENALVKNA---QVQRNKQHEVEEATNILTATRKCFRHIALDYVLQINVLQS 182
Query: 197 KQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLFPFIEKLAASVHALHQAQEDELQKLTQLR 256
K+ + L+S++ F +A FF G+ L P+++ L A + L +
Sbjct: 183 KRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRL-------------VV 229
Query: 257 DSLRGTLQLESREEHLSRKNSGCGYSIHQHQGNKQFGTEKVGFLYKKSDGIRRVWQKRKC 316
D+ + ++E + + +K+ S ++ + G G+L+K++ + W +R
Sbjct: 230 DAAKEKREMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWF 289
Query: 317 GVKYGCLTISHSTINRPPV---KLTLLTCQVRPNPEEKKCFDLVTHNRTYHFQAEDEHEC 373
++ L + P V L L T + + E + CF++V+ ++ QA+ E
Sbjct: 290 SIQNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLR 349
Query: 374 EAWVSVLQNS-----KDEALSSAFLGEPSA-GPGSWGSAGHDGEPHDLTKLLIAEVKSRP 427
+AW+ +Q S +++ S L + S+ GS S E + + V+ P
Sbjct: 350 QAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIP 409
Query: 428 GNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPSELLLALN 487
GN+ CCDCG ADP W S NLG+ CI+CSG+HR LGV FS+++SLTLD P L L
Sbjct: 410 GNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCE 469
Query: 488 MGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCT-----PEPQRL 542
+GN N V EA + G KP + YI AKYVE +F + + PE Q+
Sbjct: 470 LGNDVINRVYEANVEKMGIKKPQ-PGQRQEKEAYIRAKYVERKFVDKYSISLSPPEQQKK 528
Query: 543 WTAICNRDLLSVLEAFANG 561
+ + + + + F G
Sbjct: 529 FVSKSSEEKRLSISKFGPG 547
Score = 39.7 bits (91), Expect = 0.013
Identities = 31/129 (24%), Positives = 56/129 (43%), Gaps = 7/129 (5%)
Query: 541 RLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPLVDFII 600
+L+ A ++L + EA A+G D + P ++ SL +F++
Sbjct: 609 QLYRASYEKNLPKMAEALAHGADVNWANSEENKATP-------LIQAVLGGSLVTCEFLL 661
Query: 601 QNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIARKKHHKE 660
QNG +++ + G LH+A + + L LK A +E G+ L IA + + +
Sbjct: 662 QNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANAD 721
Query: 661 CEELLEQAQ 669
LL A+
Sbjct: 722 IVTLLRLAR 730
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 171 bits (432), Expect = 4e-42
Identities = 167/645 (25%), Positives = 265/645 (41%), Gaps = 109/645 (16%)
Query: 128 LDSLMKGQLRDGRQA---------SLSLGSRAKLEKERDRARVTGGIPGEVAQDMQRERR 178
+ +L+K LR R+A SL E R RA+ E ++ R
Sbjct: 109 IQTLVKEGLRGFREARRDFWRGAESLEAALTHNAEVPRRRAQEAE----EAGAALRTARA 164
Query: 179 IFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLFPFIEKLAASV 238
++ +Y L+ + K+ D ++ +++ AQ FQ G + L + ++L A +
Sbjct: 165 GYRGRALDYALQINVIEDKRKFDIMEFVLRLVEAQATHFQQGHEELSRLSQYRKELGAQL 224
Query: 239 HALHQAQEDELQKLTQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQHQGNKQFGTEKVG 298
H L + +S R +E R L +K G G G G
Sbjct: 225 HQL-------------VLNSAREKRDMEQRHVLLKQKELG-GEEPEPSLREGPGGLVMEG 270
Query: 299 FLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPV---KLTLLTCQVRPNPEEKKCFD 355
L+K++ + W +R ++ L + V L L T ++ P+ E + CF+
Sbjct: 271 HLFKRASNAFKTWSRRWFTIQSNQLVYQKKYKDPVTVVVDDLRLCTVKLCPDSERRFCFE 330
Query: 356 LVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSW------GSAGHD 409
+V+ +++ QA+ E + WVS +Q+S A S A L + GPG GSA
Sbjct: 331 VVSTSKSCLLQADSERLLQLWVSAVQSSIASAFSQARLDDSPRGPGQGSGHLAIGSAATL 390
Query: 410 G--------EPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRE 461
G EP + + +A+V+S GN+QCCDC P W S NLGV CIQCSG+HR
Sbjct: 391 GSGGMARGREPGGVGHV-VAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRS 449
Query: 462 LGVRFSRMQSLTLDLLGPSELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDY 521
LGV FS+++SLTLD P + L +GN N++ EA++ + KP + +
Sbjct: 450 LGVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAW 509
Query: 522 IMAKYVEHRF----------------------------------ARRCTPEPQR------ 541
I AKYVE +F + R PEP
Sbjct: 510 IHAKYVEKKFLTKLPEIRGRRGGRGRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDLGSL 569
Query: 542 -----LWTAICN-RDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPL 595
L+ A + L ++ +A A+G D G D P ++ SL
Sbjct: 570 HPGALLFRASGHPPSLPTMADALAHGADVNWVNGGQDNATP-------LIQATAANSLLA 622
Query: 596 VDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIARK 655
+F++QNG +++ + G LH+A + L LK A +G + G L IA +
Sbjct: 623 CEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGARDSEGRDPLTIAME 682
Query: 656 KHHKECEELLE----------QAQAGTFAF-PLHVDYSWVISTEP 689
+ + LL Q QAG + + D+S + S +P
Sbjct: 683 TANADIVTLLRLAKMREAEAAQGQAGDETYLDIFRDFSLMASDDP 727
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 129 bits (324), Expect = 1e-29
Identities = 95/296 (32%), Positives = 143/296 (48%), Gaps = 32/296 (10%)
Query: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
+T+HF+A E +AWV +++ +L + S A + I
Sbjct: 886 QTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEA-----------VAI 934
Query: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
+++ GNS C DCGA +PTW S NLG L CI+CSG+HR LG SR++SL LD P
Sbjct: 935 QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLD-DWPR 993
Query: 481 ELLLALN-MGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCT--- 536
EL L L +GN + N V E+ + G KPS +S R +I AKY + F +
Sbjct: 994 ELTLVLTAIGNDTANRVWESD--TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSE 1051
Query: 537 -PEPQRLWTAICNRDLLSVLEAFANGQ--DFGQPLPGPDAQAPEELVLHLAVKVANQASL 593
P ++LW A+ +D+ +VL A+ + + P ++P LHLA ++A+ +
Sbjct: 1052 EPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSP----LHLAAELAH---V 1104
Query: 594 PLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETA 649
+ ++ G + A+ A G TAL YA C +LL+ G E G A
Sbjct: 1105 VITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQH----GCPGEGGSAA 1156
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 129 bits (324), Expect = 1e-29
Identities = 95/296 (32%), Positives = 143/296 (48%), Gaps = 32/296 (10%)
Query: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
+T+HF+A E +AWV +++ +L + S A + I
Sbjct: 530 QTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEA-----------VAI 578
Query: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
+++ GNS C DCGA +PTW S NLG L CI+CSG+HR LG SR++SL LD P
Sbjct: 579 QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLD-DWPR 637
Query: 481 ELLLALN-MGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCT--- 536
EL L L +GN + N V E+ + G KPS +S R +I AKY + F +
Sbjct: 638 ELTLVLTAIGNDTANRVWESD--TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSE 695
Query: 537 -PEPQRLWTAICNRDLLSVLEAFANGQ--DFGQPLPGPDAQAPEELVLHLAVKVANQASL 593
P ++LW A+ +D+ +VL A+ + + P ++P LHLA ++A+ +
Sbjct: 696 EPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSP----LHLAAELAH---V 748
Query: 594 PLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETA 649
+ ++ G + A+ A G TAL YA C +LL+ G E G A
Sbjct: 749 VITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQH----GCPGEGGSAA 800
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 119 bits (299), Expect = 1e-26
Identities = 93/292 (31%), Positives = 138/292 (47%), Gaps = 26/292 (8%)
Query: 349 EEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGH 408
EE+K + +T HF+A E +AWV +Q+ +L S + + S A
Sbjct: 271 EEEKFMIVSVTGQTCHFKATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEA-- 328
Query: 409 DGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSR 468
+ + +++ GNS C DC +P W S NLGVL CI+CSG+HR LG R SR
Sbjct: 329 ---------MALQSIQNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSR 379
Query: 469 MQSLTLDLLGPSELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYV 527
++SL LD P EL + ++GN N + E S G KPS ES + +I +KY
Sbjct: 380 VRSLELD-DWPVELRKVMSSIGNDLANSIWEGS--SQGQTKPSIESTREEKERWIRSKY- 435
Query: 528 EHRFARRCTP-----EPQRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLH 582
EH+ P Q L A + DL + + A+G + + + LH
Sbjct: 436 EHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGS--REEVNETCGEGDGCTALH 493
Query: 583 LAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634
LA + N + L +I G + A+ A GNTAL YA + +C+ +LL+
Sbjct: 494 LACRKGN---VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 118 bits (295), Expect = 3e-26
Identities = 89/279 (31%), Positives = 135/279 (48%), Gaps = 24/279 (8%)
Query: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
+T+HF+A E +AWV +Q+ +L S + + S A + +
Sbjct: 396 QTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKA-----------MAL 444
Query: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
+++ GN+ C DC +P W S NLGVL CI+CSG+HR LG R SR++SL LD P
Sbjct: 445 QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELD-DWPV 503
Query: 481 ELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFAR--RCTP 537
EL + ++GN N + E S G KPS +S + +I +KY E F CT
Sbjct: 504 ELRKVMSSIGNDLANSIWEGS--SQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTE 561
Query: 538 EP--QRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPL 595
Q+L A + DL + + A+G + + + LHLA + N + L
Sbjct: 562 LSLGQQLLRATADEDLQTAILLLAHGS--REEVNETCGEGDGCTALHLACRKGN---VVL 616
Query: 596 VDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634
+I G + A+ A GNTAL YA + +C+ +LL+
Sbjct: 617 AQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 118 bits (295), Expect = 3e-26
Identities = 88/279 (31%), Positives = 132/279 (47%), Gaps = 24/279 (8%)
Query: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
+T+HF+A E +AWV +++ +L S + + S A + +
Sbjct: 511 QTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEA-----------MAL 559
Query: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
+++ GNS C DC +P W S NLG L CI+CSG+HR LG SR++SL LD P
Sbjct: 560 QSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLD-DWPV 618
Query: 481 ELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFAR--RCTP 537
EL+ + ++GN N V E S G KPS +S + +I AKY + F CT
Sbjct: 619 ELIKVMSSIGNELANSVWEES--SQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTE 676
Query: 538 EP--QRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPL 595
Q L A + DL + + A+G + + LHLA + N + L
Sbjct: 677 LSLGQHLLRATADEDLRTAILLLAHGS--RDEVNETCGEGDGRTALHLACRKGN---VVL 731
Query: 596 VDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634
+I G + A+ A GNTAL YA + +C+ +LL+
Sbjct: 732 AQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 770
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 118 bits (295), Expect = 3e-26
Identities = 88/279 (31%), Positives = 132/279 (47%), Gaps = 24/279 (8%)
Query: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
+T+HF+A E +AWV +++ +L S + + S A + +
Sbjct: 564 QTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEA-----------MAL 612
Query: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
+++ GNS C DC +P W S NLG L CI+CSG+HR LG SR++SL LD P
Sbjct: 613 QSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLD-DWPV 671
Query: 481 ELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFAR--RCTP 537
EL+ + ++GN N V E S G KPS +S + +I AKY + F CT
Sbjct: 672 ELIKVMSSIGNELANSVWEES--SQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTE 729
Query: 538 EP--QRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPL 595
Q L A + DL + + A+G + + LHLA + N + L
Sbjct: 730 LSLGQHLLRATADEDLRTAILLLAHGS--RDEVNETCGEGDGRTALHLACRKGN---VVL 784
Query: 596 VDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634
+I G + A+ A GNTAL YA + +C+ +LL+
Sbjct: 785 AQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 117 bits (292), Expect = 6e-26
Identities = 88/279 (31%), Positives = 135/279 (48%), Gaps = 24/279 (8%)
Query: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
+T+HF+A E +AWV +Q+ +L S + + S A + +
Sbjct: 396 QTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEA-----------MAL 444
Query: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
+++ GN+ C DC +P W S NLGVL CI+CSG+HR LG R SR++SL LD P
Sbjct: 445 QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELD-DWPV 503
Query: 481 ELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFAR--RCTP 537
EL + ++GN N + E S G KP+ +S + +I +KY E F CT
Sbjct: 504 ELRKVMSSIGNDLANSIWEGS--SQGRTKPTEKSTREEKERWIRSKYEEKLFLAPLPCTE 561
Query: 538 EP--QRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPL 595
Q+L A + DL + + A+G + + + LHLA + N + L
Sbjct: 562 LSLGQQLLRATADEDLQTAILLLAHGS--REEVNETCGEGDGCTALHLACRKGN---VVL 616
Query: 596 VDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634
+I G + A+ A GNTAL YA + +C+ +LL+
Sbjct: 617 AQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 115 bits (289), Expect = 1e-25
Identities = 88/279 (31%), Positives = 134/279 (48%), Gaps = 24/279 (8%)
Query: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
+T+HF+A E +AWV +Q+ +L S + + S A + +
Sbjct: 396 QTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEA-----------MAL 444
Query: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
+++ GN+ C DC +P W S NLGVL CI+CSG+H LG R SR++SL LD P
Sbjct: 445 QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELD-DWPV 503
Query: 481 ELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFAR--RCTP 537
EL + ++GN N + E S G KPS +S + +I +KY E F CT
Sbjct: 504 ELRKVMSSIGNDLANSIWEGS--SQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTE 561
Query: 538 EP--QRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPL 595
Q+L A + DL + + A+G + + + LHLA + N + L
Sbjct: 562 LSLGQQLLWATADEDLQTAILLLAHGS--REEVNETCGEGDGCTALHLACRKGN---VVL 616
Query: 596 VDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634
+I G + A+ A GNTAL YA + +C+ +LL+
Sbjct: 617 AQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 114 bits (284), Expect = 5e-25
Identities = 88/279 (31%), Positives = 133/279 (47%), Gaps = 24/279 (8%)
Query: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
+T+HF+A E +AWV +Q+ +L S + + S A + +
Sbjct: 419 QTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEA-----------MAL 467
Query: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
+++ GN+ C D +P W S NLGVL CI+CSG+HR LG R SR++SL LD P
Sbjct: 468 QSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELD-DWPV 526
Query: 481 ELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFAR--RCTP 537
EL + ++GN N + E S G KPS +S + +I +KY E F CT
Sbjct: 527 ELRKVMSSIGNDLANSIWEGS--SQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTE 584
Query: 538 EP--QRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPL 595
Q L A + DL + + A+G + + + LHLA + N + L
Sbjct: 585 LSLGQHLLRATADEDLQTAILLLAHGS--REEVNETCGEGDGCTALHLACRKGN---VVL 639
Query: 596 VDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634
+I G + A+ A GNTAL YA + +C+ +LL+
Sbjct: 640 AQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 111 bits (278), Expect = 3e-24
Identities = 89/295 (30%), Positives = 133/295 (45%), Gaps = 29/295 (9%)
Query: 349 EEKKCFDLVTHN---RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGS 405
E ++ F+ V + +T+HF+A E E WV +Q +L + G+ +
Sbjct: 602 EAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNA 661
Query: 406 AGHDGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVR 465
A L + V++ GNS C DC A +P W S NLG L CI+CSG+HR LG
Sbjct: 662 A-----------LAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAH 710
Query: 466 FSRMQSLTLDLLGPSELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAK 525
SR++SL LD P L + MGN N V E L + P P A + R +I AK
Sbjct: 711 LSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKER--WIRAK 768
Query: 526 YVEHRFARRC----TPEPQRLWTAICNRD--LLSVLEAFANGQDFGQPLPGPDAQAPEEL 579
Y + F P Q+L A+ D LL +L A + ++ + D +
Sbjct: 769 YEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRT---- 824
Query: 580 VLHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634
LHL+ +AN + +I G + ++ A G T L YA +C +L++
Sbjct: 825 ALHLSSAMAN---VVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 111 bits (278), Expect = 3e-24
Identities = 87/279 (31%), Positives = 133/279 (47%), Gaps = 24/279 (8%)
Query: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
+T+HF+A E +AWV +Q+ +L S + + S A + +
Sbjct: 419 QTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEA-----------MAL 467
Query: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
+++ GN+ C DC +P W S NLGVL CI+CSG+HR LG SR++SL LD P
Sbjct: 468 QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELD-DWPV 526
Query: 481 ELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFAR--RCTP 537
EL + ++ N N + E S G KPS +S + +I +KY E F CT
Sbjct: 527 ELRKVMSSIVNDLANSIWEGS--SQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTE 584
Query: 538 EP--QRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPL 595
Q+L A + DL + + A+G + + + LHLA + N + L
Sbjct: 585 LSLGQQLLRATADEDLQTAILLLAHGS--CEEVNETCGEGDGCTALHLACRKGN---VVL 639
Query: 596 VDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634
+I G + A+ A GNTAL YA + +C+ +LL+
Sbjct: 640 AQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 111 bits (277), Expect = 3e-24
Identities = 87/279 (31%), Positives = 132/279 (47%), Gaps = 26/279 (9%)
Query: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
+T+HF+A E +AWV +Q+ +L S + + S A + +
Sbjct: 419 QTWHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEA-----------MAL 467
Query: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
+++ GN+ C DC +P W S NLGVL CI+CSG+HR G R SR++SL LD P
Sbjct: 468 QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELD-DWPV 526
Query: 481 ELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFAR--RCTP 537
EL + ++GN N + E S G KPS +S + +I +KY E F CT
Sbjct: 527 ELRKVMSSIGNELANSIWEGS--SQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTE 584
Query: 538 EP--QRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPL 595
Q+L A + DL + + A+G + + + LHLA + N L
Sbjct: 585 LSLGQQLLRATTDEDLQTAILLLAHGS--REEVNETCGEGDGCTALHLACRKGNVVLEQL 642
Query: 596 VDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634
+ G + A+ A GNTAL YA + +C+ +LL+
Sbjct: 643 L-----XGVDVMARDAHGNTALTYARQASSQECINVLLQ 676
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 111 bits (277), Expect = 3e-24
Identities = 87/279 (31%), Positives = 132/279 (47%), Gaps = 26/279 (9%)
Query: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
+T+HF+A E +AWV +Q+ +L S + + S A + +
Sbjct: 419 QTWHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEA-----------MAL 467
Query: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
+++ GN+ C DC +P W S NLGVL CI+CSG+HR G R SR++SL LD P
Sbjct: 468 QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELD-DWPV 526
Query: 481 ELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFAR--RCTP 537
EL + ++GN N + E S G KPS +S + +I +KY E F CT
Sbjct: 527 ELRKVMSSIGNELANSIWEGS--SQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTE 584
Query: 538 EP--QRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPL 595
Q+L A + DL + + A+G + + + LHLA + N L
Sbjct: 585 LSLGQQLLRATTDEDLQTAILLLAHGS--REEVNETCGEGDGCTALHLACRKGNVVLEQL 642
Query: 596 VDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634
+ G + A+ A GNTAL YA + +C+ +LL+
Sbjct: 643 L-----XGVDVMARDAHGNTALTYARQASSQECINVLLQ 676
>gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
3 [Homo sapiens]
Length = 1544
Score = 92.8 bits (229), Expect = 1e-18
Identities = 79/257 (30%), Positives = 113/257 (43%), Gaps = 52/257 (20%)
Query: 337 LTLLTCQVRPNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEP 396
+ L C VR + + FDL+T +R + F AE ++W + LQ + E LS + E
Sbjct: 437 IELQGCSVRET--KSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAE- 493
Query: 397 SAGPGSWGSAGHDGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCS 456
++ S N QC DCG++ P W + NLGV+ C QC+
Sbjct: 494 -------------------------KIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCA 528
Query: 457 GVHRELGVRFSRMQSLTLDL-LGPSELL-LALNMGNTSFNEVMEAQLPSHGGPKPSAESD 514
G HR LG S++QSL LD + +E++ L + +GN N LP G P A
Sbjct: 529 GQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGLHPDATP- 587
Query: 515 MGTRRDYIMAKYVEHRFARRCTPEPQ-----RLWTAIC----------NRDLLSVLEAFA 559
G R ++I KY F + P PQ +L A+C N L +EAF
Sbjct: 588 -GPRGEFISRKYRLGLFRK---PHPQYPDHSQLLQALCAAVARPNLLKNMTQLLCVEAF- 642
Query: 560 NGQDFGQPLPGPDAQAP 576
G++ P P PD P
Sbjct: 643 EGEEPWFP-PAPDGSCP 658
Score = 37.7 bits (86), Expect = 0.048
Identities = 29/83 (34%), Positives = 36/83 (43%), Gaps = 4/83 (4%)
Query: 740 EDCPPPLPVKNSSRTLVQGCARHASGDRSEVSSLSSEAPETPESLGSPASSSSLMSPLEP 799
E+ PP P S++ Q E+SSL ET LGSP+ SS SP
Sbjct: 1459 EERPPEPPPGPPSKSSPQARGSLEEQLLQELSSLILRKGETTAGLGSPSQPSSPQSPSPT 1518
Query: 800 GDPSQAPPNSEEGLREPPGTSRP 822
G P+Q P +PP TS P
Sbjct: 1519 GLPTQTPGFP----TQPPCTSSP 1537
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform a [Homo sapiens]
Length = 1205
Score = 90.5 bits (223), Expect = 6e-18
Identities = 62/186 (33%), Positives = 90/186 (48%), Gaps = 30/186 (16%)
Query: 350 EKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHD 409
+++ FDL T R + F A+ E E E W+ +Q + EALS++ + E W +A
Sbjct: 249 DRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERI-----WAAAP-- 301
Query: 410 GEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRM 469
N C DCGA P W S NL V+ C +C+G HR LG S++
Sbjct: 302 -------------------NRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKV 342
Query: 470 QSLTLDLLGPSELL--LALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYV 527
+SL +D +E L L L +GN + N A +P +PS S TRR ++ AKY
Sbjct: 343 RSLKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSEALQPS--SSPSTRRCHLEAKYR 400
Query: 528 EHRFAR 533
E ++ R
Sbjct: 401 EGKYRR 406
Score = 36.2 bits (82), Expect = 0.14
Identities = 18/45 (40%), Positives = 29/45 (64%), Gaps = 5/45 (11%)
Query: 354 FDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDE-----ALSSAFL 393
F+++T+NRT+ F+AE + E + W+ LQ + E LSSA+L
Sbjct: 143 FEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYL 187
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform c [Homo sapiens]
Length = 1450
Score = 90.5 bits (223), Expect = 6e-18
Identities = 62/186 (33%), Positives = 90/186 (48%), Gaps = 30/186 (16%)
Query: 350 EKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHD 409
+++ FDL T R + F A+ E E E W+ +Q + EALS++ + E W +A
Sbjct: 494 DRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERI-----WAAAP-- 546
Query: 410 GEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRM 469
N C DCGA P W S NL V+ C +C+G HR LG S++
Sbjct: 547 -------------------NRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKV 587
Query: 470 QSLTLDLLGPSELL--LALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYV 527
+SL +D +E L L L +GN + N A +P +PS S TRR ++ AKY
Sbjct: 588 RSLKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSEALQPS--SSPSTRRCHLEAKYR 645
Query: 528 EHRFAR 533
E ++ R
Sbjct: 646 EGKYRR 651
Score = 36.2 bits (82), Expect = 0.14
Identities = 18/45 (40%), Positives = 29/45 (64%), Gaps = 5/45 (11%)
Query: 354 FDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDE-----ALSSAFL 393
F+++T+NRT+ F+AE + E + W+ LQ + E LSSA+L
Sbjct: 388 FEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYL 432
>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
2 [Homo sapiens]
Length = 1704
Score = 80.9 bits (198), Expect = 5e-15
Identities = 61/221 (27%), Positives = 100/221 (45%), Gaps = 36/221 (16%)
Query: 351 KKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDG 410
K+ F+++T R++ F AE E E + W+ +Q S E LS + E
Sbjct: 645 KQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAE--------------- 689
Query: 411 EPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQ 470
++ N C DC A DP W S NL V+ C +C+G HR LG + S+++
Sbjct: 690 -----------KIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVR 738
Query: 471 SLTLDL-LGPSELL-LALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVE 528
SL +D + +EL+ L + +GN N+ L + +S + R+++I KY E
Sbjct: 739 SLKMDASIWSNELIELFIVIGNKRANDFWAGNLQK--DEELHMDSPVEKRKNFITQKYKE 796
Query: 529 HRFAR----RCTPEP--QRLWTAICNRDLLSVLEAFANGQD 563
+F + T E + L A+ D+L + +G D
Sbjct: 797 GKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGAD 837
Score = 41.2 bits (95), Expect = 0.004
Identities = 33/100 (33%), Positives = 54/100 (54%), Gaps = 9/100 (9%)
Query: 296 KVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQ----VRPNPEEK 351
K G+L K S +R++QKR VK+ L+IS+ + ++ VR + K
Sbjct: 485 KSGWLDKLSPQGKRMFQKR--WVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNK 542
Query: 352 KCFDLVTHNRTYHFQAEDEHECEAWVSVLQNS-KDEALSS 390
F++VT RT+ F+ E E E W+S+L N+ K ++L+S
Sbjct: 543 --FEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTS 580
>gi|6806913 centaurin, alpha 1 [Homo sapiens]
Length = 374
Score = 78.6 bits (192), Expect = 2e-14
Identities = 48/147 (32%), Positives = 75/147 (51%), Gaps = 10/147 (6%)
Query: 420 IAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGP 479
+ E+ RPGN++C DCGA DP W S LGV C+ CSG+HR + + S+++S+ LD
Sbjct: 9 VLELLQRPGNARCADCGAPDPDWASYTLGVFICLSCSGIHRNI-PQVSKVKSVRLDAWEE 67
Query: 480 SELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCTPEP 539
+++ + GN + E+++PS +P+ R +I AKY F PE
Sbjct: 68 AQVEFMASHGNDAARARFESKVPSF-YYRPTPSDCQLLREQWIRAKYERQEF---IYPEK 123
Query: 540 QRLWTAICNRDLLSVLEAFANGQDFGQ 566
Q ++A L + G+D GQ
Sbjct: 124 QEPYSAGYREGFL-----WKRGRDNGQ 145
>gi|113204622 stromal membrane-associated GTPase-activating protein
1 isoform A [Homo sapiens]
Length = 467
Score = 77.4 bits (189), Expect = 5e-14
Identities = 39/113 (34%), Positives = 60/113 (53%), Gaps = 1/113 (0%)
Query: 417 KLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDL 476
+L+++++ N C DC A P W S N+GV CI+C+G+HR LGV SR++S+ LD
Sbjct: 18 QLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQ 77
Query: 477 LGPSELLLALNMGNTSFNEVMEAQLPSH-GGPKPSAESDMGTRRDYIMAKYVE 528
++ +MGNT + EA LP + P+ + R Y KY +
Sbjct: 78 WTAEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKKYYD 130
>gi|21264558 stromal membrane-associated GTPase-activating protein 1
isoform B [Homo sapiens]
Length = 440
Score = 77.4 bits (189), Expect = 5e-14
Identities = 39/113 (34%), Positives = 60/113 (53%), Gaps = 1/113 (0%)
Query: 417 KLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDL 476
+L+++++ N C DC A P W S N+GV CI+C+G+HR LGV SR++S+ LD
Sbjct: 18 QLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQ 77
Query: 477 LGPSELLLALNMGNTSFNEVMEAQLPSH-GGPKPSAESDMGTRRDYIMAKYVE 528
++ +MGNT + EA LP + P+ + R Y KY +
Sbjct: 78 WTAEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKKYYD 130
>gi|23943872 small ArfGAP2 [Homo sapiens]
Length = 429
Score = 73.2 bits (178), Expect = 1e-12
Identities = 34/89 (38%), Positives = 49/89 (55%)
Query: 414 DLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLT 473
D + ++A + N C DC + P W S N+GV CI+C+G+HR LGV SR++S+
Sbjct: 10 DRYQAVLANLLLEEDNKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVN 69
Query: 474 LDLLGPSELLLALNMGNTSFNEVMEAQLP 502
LD ++ MGN N + EA LP
Sbjct: 70 LDQWTQEQIQCMQEMGNGKANRLYEAYLP 98
>gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform d [Homo sapiens]
Length = 1133
Score = 72.8 bits (177), Expect = 1e-12
Identities = 46/151 (30%), Positives = 70/151 (46%), Gaps = 26/151 (17%)
Query: 350 EKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHD 409
+++ FDL T R + F A+ E E E W+ +Q + EALS++ + E W +A
Sbjct: 249 DRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERI-----WAAAP-- 301
Query: 410 GEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRM 469
N C DCGA P W S NL V+ C +C+G HR LG S++
Sbjct: 302 -------------------NRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKV 342
Query: 470 QSLTLDLLGPSELLLALNMGNTSFNEVMEAQ 500
+SL +D +E L+ + ++ E Q
Sbjct: 343 RSLKMDRKVWTETLIEALCAAVTTTDLAETQ 373
Score = 36.2 bits (82), Expect = 0.14
Identities = 18/45 (40%), Positives = 29/45 (64%), Gaps = 5/45 (11%)
Query: 354 FDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDE-----ALSSAFL 393
F+++T+NRT+ F+AE + E + W+ LQ + E LSSA+L
Sbjct: 143 FEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYL 187
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,487,341
Number of Sequences: 37866
Number of extensions: 1997233
Number of successful extensions: 10473
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 294
Number of HSP's successfully gapped in prelim test: 416
Number of HSP's that attempted gapping in prelim test: 8320
Number of HSP's gapped (non-prelim): 2334
length of query: 894
length of database: 18,247,518
effective HSP length: 111
effective length of query: 783
effective length of database: 14,044,392
effective search space: 10996758936
effective search space used: 10996758936
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.