Search of human proteins with 221219050

Search of human proteins with 221219050

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo
sapiens]
         (621 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo ...  1265   0.0  
gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo s...  1176   0.0  
gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo ...  1052   0.0  
gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]         808   0.0  
gi|34915994 transducin-like enhancer protein 4 [Homo sapiens]         789   0.0  
gi|157384986 transducin-like enhancer protein 3 isoform b [Homo ...   783   0.0  
gi|157384982 transducin-like enhancer protein 3 isoform a [Homo ...   782   0.0  
gi|157384984 transducin-like enhancer protein 3 isoform c [Homo ...   779   0.0  
gi|221136834 transducin-like enhancer of split 6 isoform 1 [Homo...   218   2e-56
gi|13376099 transducin-like enhancer of split 6 isoform 2 [Homo ...   218   2e-56
gi|39812027 amino-terminal enhancer of split isoform c [Homo sap...   121   2e-27
gi|39812019 amino-terminal enhancer of split isoform a [Homo sap...   121   2e-27
gi|5706731 amino-terminal enhancer of split isoform b [Homo sapi...   121   2e-27
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             89   9e-18
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             89   9e-18
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             89   9e-18
gi|26665869 WD repeat domain 51B [Homo sapiens]                        83   7e-16
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    80   4e-15
gi|113865883 WD repeat domain 38 [Homo sapiens]                        80   7e-15
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is...    75   2e-13
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i...    75   2e-13
gi|5174447 guanine nucleotide binding protein (G protein), beta ...    72   2e-12
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     72   2e-12
gi|8923881 WD SOCS-box protein 2 [Homo sapiens]                        70   6e-12
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...    69   1e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     68   3e-11
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H...    66   1e-10
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ...    66   1e-10
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [...    64   3e-10
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     64   4e-10

>gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo
           sapiens]
          Length = 621

 Score = 1265 bits (3274), Expect = 0.0
 Identities = 621/621 (100%), Positives = 621/621 (100%)

Query: 1   MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60
           MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV
Sbjct: 1   MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60

Query: 61  GELNSLIGSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVDED 120
           GELNSLIGSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVDED
Sbjct: 61  GELNSLIGSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVDED 120

Query: 121 QPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILNDLPASTPASK 180
           QPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILNDLPASTPASK
Sbjct: 121 QPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILNDLPASTPASK 180

Query: 181 SCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHSTLN 240
           SCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHSTLN
Sbjct: 181 SCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHSTLN 240

Query: 241 GDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFH 300
           GDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFH
Sbjct: 241 GDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFH 300

Query: 301 VSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKV 360
           VSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKV
Sbjct: 301 VSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKV 360

Query: 361 WDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAE 420
           WDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAE
Sbjct: 361 WDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAE 420

Query: 421 LTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGT 480
           LTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGT
Sbjct: 421 LTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGT 480

Query: 481 RLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKP 540
           RLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKP
Sbjct: 481 RLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKP 540

Query: 541 EKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISR 600
           EKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISR
Sbjct: 541 EKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISR 600

Query: 601 NNKYIVTGSGDKKATVYEVVY 621
           NNKYIVTGSGDKKATVYEVVY
Sbjct: 601 NNKYIVTGSGDKKATVYEVVY 621


>gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo
           sapiens]
          Length = 743

 Score = 1176 bits (3042), Expect = 0.0
 Identities = 599/690 (86%), Positives = 605/690 (87%), Gaps = 71/690 (10%)

Query: 1   MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60
           MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV
Sbjct: 56  MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 115

Query: 61  GELNSLIGS-----ASPSPPESLVEEERPSGPGGGG------------------------ 91
           GELNSLIG      +  +PP  L    RP+G  GG                         
Sbjct: 116 GELNSLIGQQLQPLSHHAPPVPLT--PRPAGLVGGSATGLLALSGALAAQAQLAAAVKED 173

Query: 92  ------------------------KQRADEKEPSG----------------PYESDEDKS 111
                                   +   +E+ PSG                PYESDEDKS
Sbjct: 174 RAGVEAEGSRVERAPSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKS 233

Query: 112 DYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILND 171
           DYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILND
Sbjct: 234 DYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILND 293

Query: 172 LPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSF 231
           LPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSF
Sbjct: 294 LPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSF 353

Query: 232 SLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIP 291
           SLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIP
Sbjct: 354 SLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIP 413

Query: 292 GGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVY 351
           GGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVY
Sbjct: 414 GGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVY 473

Query: 352 TGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLA 411
           TGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLA
Sbjct: 474 TGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLA 533

Query: 412 APTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGAS 471
           APTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGAS
Sbjct: 534 APTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGAS 593

Query: 472 CIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSN 531
           CIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSN
Sbjct: 594 CIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSN 653

Query: 532 VEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESS 591
           VEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESS
Sbjct: 654 VEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESS 713

Query: 592 SVLSCDISRNNKYIVTGSGDKKATVYEVVY 621
           SVLSCDISRNNKYIVTGSGDKKATVYEVVY
Sbjct: 714 SVLSCDISRNNKYIVTGSGDKKATVYEVVY 743


>gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo
           sapiens]
          Length = 706

 Score = 1052 bits (2720), Expect = 0.0
 Identities = 538/630 (85%), Positives = 544/630 (86%), Gaps = 72/630 (11%)

Query: 1   MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60
           MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV
Sbjct: 69  MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 128

Query: 61  GELNSLIGS------ASPSPPESLVEEERPSGPGGGG----------------------- 91
           GELNSLIG       +  +PP  L    RP+G  GG                        
Sbjct: 129 GELNSLIGQQQLQPLSHHAPPVPLT--PRPAGLVGGSATGLLALSGALAAQAQLAAAVKE 186

Query: 92  -------------------------KQRADEKEPSG----------------PYESDEDK 110
                                    +   +E+ PSG                PYESDEDK
Sbjct: 187 DRAGVEAEGSRVERAPSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDK 246

Query: 111 SDYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILN 170
           SDYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILN
Sbjct: 247 SDYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILN 306

Query: 171 DLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTS 230
           DLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTS
Sbjct: 307 DLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTS 366

Query: 231 FSLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSI 290
           FSLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSI
Sbjct: 367 FSLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSI 426

Query: 291 PGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHV 350
           PGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHV
Sbjct: 427 PGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHV 486

Query: 351 YTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDL 410
           YTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDL
Sbjct: 487 YTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDL 546

Query: 411 AAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGA 470
           AAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGA
Sbjct: 547 AAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGA 606

Query: 471 SCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESS 530
           SCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESS
Sbjct: 607 SCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESS 666

Query: 531 NVEILHVRKPEKYQLHLHESCVLSLKFASC 560
           NVEILHVRKPEKYQLHLHESCVLSLKFASC
Sbjct: 667 NVEILHVRKPEKYQLHLHESCVLSLKFASC 696


>gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]
          Length = 770

 Score =  808 bits (2086), Expect = 0.0
 Identities = 435/716 (60%), Positives = 502/716 (70%), Gaps = 97/716 (13%)

Query: 1   MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60
           MQRHYVMYYEMSYGLNIEMHKQ EI KRL+ ICAQ+IPFL+QEHQQQV QAVERAKQVT+
Sbjct: 57  MQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTM 116

Query: 61  GELNSLIG---------SASPSPPESL--------------------------------- 78
            ELN++IG         S    PP  L                                 
Sbjct: 117 AELNAIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSH 176

Query: 79  -----------VEEERPSGPGGGG------KQRADEKEPSGPYESDEDK----------- 110
                       E  R   PG           R  +K  +GP  S++ K           
Sbjct: 177 LAIKDDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSH 236

Query: 111 -------SDYNLVVD---EDQPSEPPSPATTPC-GKVPICIPARRDLVDSPASLASSLGS 159
                  SD NLVVD   ED  S   SPA +P    +      ++D   SPAS ASS  S
Sbjct: 237 YDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASS 296

Query: 160 PLPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTD------ 213
              ++KE+ L++  ASTP  KS   +P  D  TPG S+   L     KP P+ D      
Sbjct: 297 TSLKSKEMSLHE-KASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKP-PAIDPLVNQA 354

Query: 214 SVALRSPLTLSSPFTTSFSLGSHSTLNGDLSVP-SSYVSLH-LSPQVSSS------VVYG 265
           +  LR+PL +  P+   F +  H+ +NG+L+ P ++Y SLH +SPQ+S++      V YG
Sbjct: 355 AAGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAYG 414

Query: 266 RSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRH 325
           RSP++ F+  PH+R  ++  +L  IPGGKPAYSFHV+ADGQMQPVPFP DAL+G GIPRH
Sbjct: 415 RSPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRH 474

Query: 326 ARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIR 385
           ARQ++TL HGEVVCAVTIS  T+HVYTGGKGCVKVWD+  PG K+PV+QLDCLNRDNYIR
Sbjct: 475 ARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIR 534

Query: 386 SCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCS 445
           SCKLLPDG +LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALA+SPD+KVCFSCCS
Sbjct: 535 SCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCS 594

Query: 446 DGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQH 505
           DGNI VWDL NQT+VRQFQGHTDGASCIDIS+ GT+LWTGGLDNTVR WDLREGRQLQQH
Sbjct: 595 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH 654

Query: 506 DFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRWFV 565
           DF+SQIFSLG+CP  +WLAVGMESSNVE+LHV KP+KYQLHLHESCVLSLKFA CG+WFV
Sbjct: 655 DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFV 714

Query: 566 STGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY 621
           STGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS ++KYIVTGSGDKKATVYEV+Y
Sbjct: 715 STGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 770


>gi|34915994 transducin-like enhancer protein 4 [Homo sapiens]
          Length = 773

 Score =  789 bits (2038), Expect = 0.0
 Identities = 425/712 (59%), Positives = 496/712 (69%), Gaps = 92/712 (12%)

Query: 1   MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60
           MQRHYVMYYEMSYGLNIEMHKQAEIVKRL+ ICAQ+IPFL+QEHQQQV+QAVERAKQVT+
Sbjct: 63  MQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTM 122

Query: 61  GELNSLIGS----------------ASPSPPESLVEEERPSGPGG---------GGKQRA 95
            ELN++IG                  +P P         P G            GG+   
Sbjct: 123 AELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHL 182

Query: 96  DEKEPSGPYESDEDKSDYNLVVDEDQPSEPPSPATTPCGKVPIC------------IPAR 143
             K+    +++D  +   ++      PS     A                      I AR
Sbjct: 183 PIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAAR 242

Query: 144 RD----------LVD-SPASLASSLGSPLPRAKE-------LILNDLP---------AST 176
            D          +VD S    +S  GSP    +E       L+  D P         +ST
Sbjct: 243 YDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLLKKDAPISPASIASSSST 302

Query: 177 PASKSCDSS----------------PPQDASTPGPSSASHLCQLAAKPAPSTDSVA--LR 218
           P+SKS + S                P  DA TPG +S   L  +  KP P  D +A  LR
Sbjct: 303 PSSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKP-PGVDPLASSLR 361

Query: 219 SPLTLSSPFTTSFSLGSHSTLNGDLSVP-SSYVSLH-LSPQVS-------SSVVYGRSPV 269
           +P+ +  P+ T F +  H+ +NG+L+ P ++Y  LH +SPQ+S       ++  YGRSPV
Sbjct: 362 TPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSPV 421

Query: 270 MAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQL 329
           + F+ H H+R  ++  +L  IPGGKPAYSFHVSADGQMQPVPFP DAL+G GIPRHARQ+
Sbjct: 422 VGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQI 481

Query: 330 HTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKL 389
           +TL HGEVVCAVTIS  T+HVYTGGKGCVKVWD+  PG K+PV+QLDCLNRDNYIRSC+L
Sbjct: 482 NTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRL 541

Query: 390 LPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNI 449
           LPDGR+LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALA+SPD+KVCFSCCSDGNI
Sbjct: 542 LPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNI 601

Query: 450 VVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSS 509
            VWDL NQT+VRQFQGHTDGASCIDIS+ GT+LWTGGLDNTVR WDLREGRQLQQHDF+S
Sbjct: 602 AVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTS 661

Query: 510 QIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVSTGK 569
           QIFSLG+CP  +WLAVGME+SNVE+LHV KP+KYQLHLHESCVLSLKFA CG+WFVSTGK
Sbjct: 662 QIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGK 721

Query: 570 DNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY 621
           DNLLNAWRTPYGASIFQSKESSSVLSCDIS ++KYIVTGSGDKKATVYEV+Y
Sbjct: 722 DNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 773


>gi|157384986 transducin-like enhancer protein 3 isoform b [Homo
           sapiens]
          Length = 769

 Score =  783 bits (2023), Expect = 0.0
 Identities = 426/718 (59%), Positives = 497/718 (69%), Gaps = 102/718 (14%)

Query: 1   MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60
           MQRHYVMYYEMSYGLNIEMHKQ EI KRL+ I AQI+PFL+QEHQQQV QAVERAKQVT+
Sbjct: 57  MQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTM 116

Query: 61  GELNSLIGS----------ASPSPPESLVEEERPSGPGG-----------------GGKQ 93
            ELN++IG           A+  PP  L        P G                 G + 
Sbjct: 117 TELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQA 176

Query: 94  RADEKEPSGPYESD--EDKSDYNLVVDEDQPSEPPSPATTPCGKVPICIPARR------- 144
               K+    +E D  E +S  N  V    PSE    +    G     + A++       
Sbjct: 177 HLTVKDEKNHHELDHRERESSANNSV---SPSESLRASEKHRGSADYSMEAKKRKAEEKD 233

Query: 145 -------------DLV------DSPASLASSLGSP----LPRAKELILNDLP-------- 173
                        DLV      D      S   SP    L +A+ L   D P        
Sbjct: 234 SLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSL-KKDAPTSPASVAS 292

Query: 174 -ASTPASKSCD----------------SSPPQDASTPGPSSASHLCQLAAKPAPSTDSV- 215
            +STP+SK+ D                 +P  DA TPG S+   L  +  KP P  D + 
Sbjct: 293 SSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKP-PGMDPIA 351

Query: 216 -ALRSPLTLSSPFTTSFSLGSHSTLNGDLSVPSSYVSLH-LSPQVS-----SSVVYGRSP 268
            ALR+P++++S +   F++ SH  +NG L+ P +Y  LH + PQ+S     ++  YGRSP
Sbjct: 352 SALRTPISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSP 411

Query: 269 VMA-----FESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIP 323
           +++     F+ HP +R + + SSL SIPGGKPAYSFHVSADGQMQPVPFP DAL G GIP
Sbjct: 412 MVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIP 471

Query: 324 RHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNY 383
           RHARQ++TL+HGEVVCAVTIS  T+HVYTGGKGCVK+WD+ QPG+K+P++QLDCLNRDNY
Sbjct: 472 RHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNY 531

Query: 384 IRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSC 443
           IRSCKLLPDGR+LIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALA+SPDAKVCFSC
Sbjct: 532 IRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSC 591

Query: 444 CSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQ 503
           CSDGNI VWDL NQT+VRQFQGHTDGASCIDIS  GT+LWTGGLDNTVR WDLREGRQLQ
Sbjct: 592 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQ 651

Query: 504 QHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRW 563
           QHDF+SQIFSLG+CP  +WLAVGMESSNVE+LH  KP+KYQLHLHESCVLSLKFA CG+W
Sbjct: 652 QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKW 711

Query: 564 FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY 621
           FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS ++KYIVTGSGDKKATVYEV+Y
Sbjct: 712 FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 769


>gi|157384982 transducin-like enhancer protein 3 isoform a [Homo
           sapiens]
          Length = 772

 Score =  782 bits (2020), Expect = 0.0
 Identities = 426/721 (59%), Positives = 497/721 (68%), Gaps = 105/721 (14%)

Query: 1   MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60
           MQRHYVMYYEMSYGLNIEMHKQ EI KRL+ I AQI+PFL+QEHQQQV QAVERAKQVT+
Sbjct: 57  MQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTM 116

Query: 61  GELNSLIGS----------ASPSPPESLVEEERPSGPGG-----------------GGKQ 93
            ELN++IG           A+  PP  L        P G                 G + 
Sbjct: 117 TELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQA 176

Query: 94  RADEKEPSGPYESD--EDKSDYNLVVDEDQPSEPPSPATTPCGKVPICIPARR------- 144
               K+    +E D  E +S  N  V    PSE    +    G     + A++       
Sbjct: 177 HLTVKDEKNHHELDHRERESSANNSV---SPSESLRASEKHRGSADYSMEAKKRKAEEKD 233

Query: 145 -------------DLV------DSPASLASSLGSP----LPRAKELILNDLP-------- 173
                        DLV      D      S   SP    L +A+ L   D P        
Sbjct: 234 SLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSL-KKDAPTSPASVAS 292

Query: 174 -ASTPASKSCD----------------SSPPQDASTPGPSSASHLCQLAAKPAPSTDSV- 215
            +STP+SK+ D                 +P  DA TPG S+   L  +  KP P  D + 
Sbjct: 293 SSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKP-PGMDPIG 351

Query: 216 ----ALRSPLTLSSPFTTSFSLGSHSTLNGDLSVPSSYVSLH-LSPQVS-----SSVVYG 265
               ALR+P++++S +   F++ SH  +NG L+ P +Y  LH + PQ+S     ++  YG
Sbjct: 352 IMASALRTPISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYG 411

Query: 266 RSPVMA-----FESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGA 320
           RSP+++     F+ HP +R + + SSL SIPGGKPAYSFHVSADGQMQPVPFP DAL G 
Sbjct: 412 RSPMVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGP 471

Query: 321 GIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNR 380
           GIPRHARQ++TL+HGEVVCAVTIS  T+HVYTGGKGCVK+WD+ QPG+K+P++QLDCLNR
Sbjct: 472 GIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNR 531

Query: 381 DNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVC 440
           DNYIRSCKLLPDGR+LIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALA+SPDAKVC
Sbjct: 532 DNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVC 591

Query: 441 FSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGR 500
           FSCCSDGNI VWDL NQT+VRQFQGHTDGASCIDIS  GT+LWTGGLDNTVR WDLREGR
Sbjct: 592 FSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGR 651

Query: 501 QLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASC 560
           QLQQHDF+SQIFSLG+CP  +WLAVGMESSNVE+LH  KP+KYQLHLHESCVLSLKFA C
Sbjct: 652 QLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYC 711

Query: 561 GRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVV 620
           G+WFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS ++KYIVTGSGDKKATVYEV+
Sbjct: 712 GKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVI 771

Query: 621 Y 621
           Y
Sbjct: 772 Y 772


>gi|157384984 transducin-like enhancer protein 3 isoform c [Homo
           sapiens]
          Length = 760

 Score =  779 bits (2012), Expect = 0.0
 Identities = 423/709 (59%), Positives = 494/709 (69%), Gaps = 93/709 (13%)

Query: 1   MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60
           MQRHYVMYYEMSYGLNIEMHKQ EI KRL+ I AQI+PFL+QEHQQQV QAVERAKQVT+
Sbjct: 57  MQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTM 116

Query: 61  GELNSLIGS----------ASPSPPESLVEEERPSGPGG-----------------GGKQ 93
            ELN++IG           A+  PP  L        P G                 G + 
Sbjct: 117 TELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQA 176

Query: 94  RADEKEPSGPYESD--EDKSDYNLVVDEDQPSEPPSPATTPCGKVPICIPARR------- 144
               K+    +E D  E +S  N  V    PSE    +    G     + A++       
Sbjct: 177 HLTVKDEKNHHELDHRERESSANNSV---SPSESLRASEKHRGSADYSMEAKKRKAEEKD 233

Query: 145 -------------DLV------DSPASLASSLGSP----LPRAKELILNDLP-------- 173
                        DLV      D      S   SP    L +A+ L   D P        
Sbjct: 234 SLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSL-KKDAPTSPASVAS 292

Query: 174 -ASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSV---------ALRSPLTL 223
            +STP+SK+ D      +STPG  S +   +  A P P T +          ALR+P+++
Sbjct: 293 SSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDA-PTPGTSTTPGLRSMPASALRTPISI 351

Query: 224 SSPFTTSFSLGSHSTLNGDLSVPSSYVSLH-LSPQVS-----SSVVYGRSPVMA-----F 272
           +S +   F++ SH  +NG L+ P +Y  LH + PQ+S     ++  YGRSP+++     F
Sbjct: 352 TSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGAVGF 411

Query: 273 ESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTL 332
           + HP +R + + SSL SIPGGKPAYSFHVSADGQMQPVPFP DAL G GIPRHARQ++TL
Sbjct: 412 DPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTL 471

Query: 333 AHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 392
           +HGEVVCAVTIS  T+HVYTGGKGCVK+WD+ QPG+K+P++QLDCLNRDNYIRSCKLLPD
Sbjct: 472 SHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPD 531

Query: 393 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVW 452
           GR+LIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALA+SPDAKVCFSCCSDGNI VW
Sbjct: 532 GRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVW 591

Query: 453 DLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIF 512
           DL NQT+VRQFQGHTDGASCIDIS  GT+LWTGGLDNTVR WDLREGRQLQQHDF+SQIF
Sbjct: 592 DLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIF 651

Query: 513 SLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNL 572
           SLG+CP  +WLAVGMESSNVE+LH  KP+KYQLHLHESCVLSLKFA CG+WFVSTGKDNL
Sbjct: 652 SLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNL 711

Query: 573 LNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY 621
           LNAWRTPYGASIFQSKESSSVLSCDIS ++KYIVTGSGDKKATVYEV+Y
Sbjct: 712 LNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 760


>gi|221136834 transducin-like enhancer of split 6 isoform 1 [Homo
           sapiens]
          Length = 572

 Score =  218 bits (554), Expect = 2e-56
 Identities = 114/314 (36%), Positives = 182/314 (57%), Gaps = 10/314 (3%)

Query: 315 DALVGAG----IPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDV-GQPGA- 368
           DAL G      +P    ++  LAHGE+V A  IS  T+HV+T G+  +KVW + GQ    
Sbjct: 262 DALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAED 321

Query: 369 KTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGG-EASTLSIWDLAAPTPRIKAELTSSAPA 427
           + P + L       ++R+C L  + RSL+ GG   +++S+WDLAAP+  +K +L  +   
Sbjct: 322 RFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGLN 381

Query: 428 CYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGL 487
           C AL  + DA + F+  + G + +WDL++Q++VR  +G+ DG   I +  Y   +WTGG 
Sbjct: 382 CQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYN--IWTGGP 439

Query: 488 DNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHL 547
           D  +RCWD R   +  ++ F SQI SL H P +DW+ +GM +    +      +++ +  
Sbjct: 440 DACLRCWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVGQ 499

Query: 548 HESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVT 607
            +S +LS+KF+  G+W+ S G D+ L  +  P G  +F+  E S V  CD+S NN+ +VT
Sbjct: 500 KDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMSPVTCCDVSSNNRLVVT 559

Query: 608 GSGDKKATVYEVVY 621
           GSG+  A+VY++ Y
Sbjct: 560 GSGE-HASVYQITY 572


>gi|13376099 transducin-like enhancer of split 6 isoform 2 [Homo
           sapiens]
          Length = 449

 Score =  218 bits (554), Expect = 2e-56
 Identities = 114/314 (36%), Positives = 182/314 (57%), Gaps = 10/314 (3%)

Query: 315 DALVGAG----IPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDV-GQPGA- 368
           DAL G      +P    ++  LAHGE+V A  IS  T+HV+T G+  +KVW + GQ    
Sbjct: 139 DALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAED 198

Query: 369 KTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGG-EASTLSIWDLAAPTPRIKAELTSSAPA 427
           + P + L       ++R+C L  + RSL+ GG   +++S+WDLAAP+  +K +L  +   
Sbjct: 199 RFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGLN 258

Query: 428 CYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGL 487
           C AL  + DA + F+  + G + +WDL++Q++VR  +G+ DG   I +  Y   +WTGG 
Sbjct: 259 CQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYN--IWTGGP 316

Query: 488 DNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHL 547
           D  +RCWD R   +  ++ F SQI SL H P +DW+ +GM +    +      +++ +  
Sbjct: 317 DACLRCWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVGQ 376

Query: 548 HESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVT 607
            +S +LS+KF+  G+W+ S G D+ L  +  P G  +F+  E S V  CD+S NN+ +VT
Sbjct: 377 KDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMSPVTCCDVSSNNRLVVT 436

Query: 608 GSGDKKATVYEVVY 621
           GSG+  A+VY++ Y
Sbjct: 437 GSGE-HASVYQITY 449


>gi|39812027 amino-terminal enhancer of split isoform c [Homo
           sapiens]
          Length = 196

 Score =  121 bits (304), Expect = 2e-27
 Identities = 57/67 (85%), Positives = 64/67 (95%)

Query: 1   MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60
           MQRHYVMYYEMSYGLNIEMHKQAEIVKRL+GICAQ++P+L+QEHQQQVL A+ERAKQVT 
Sbjct: 57  MQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTA 116

Query: 61  GELNSLI 67
            ELNS+I
Sbjct: 117 PELNSII 123


>gi|39812019 amino-terminal enhancer of split isoform a [Homo
           sapiens]
          Length = 264

 Score =  121 bits (304), Expect = 2e-27
 Identities = 57/67 (85%), Positives = 64/67 (95%)

Query: 1   MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60
           MQRHYVMYYEMSYGLNIEMHKQAEIVKRL+GICAQ++P+L+QEHQQQVL A+ERAKQVT 
Sbjct: 124 MQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTA 183

Query: 61  GELNSLI 67
            ELNS+I
Sbjct: 184 PELNSII 190


>gi|5706731 amino-terminal enhancer of split isoform b [Homo
           sapiens]
          Length = 197

 Score =  121 bits (304), Expect = 2e-27
 Identities = 57/67 (85%), Positives = 64/67 (95%)

Query: 1   MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60
           MQRHYVMYYEMSYGLNIEMHKQAEIVKRL+GICAQ++P+L+QEHQQQVL A+ERAKQVT 
Sbjct: 57  MQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTA 116

Query: 61  GELNSLI 67
            ELNS+I
Sbjct: 117 PELNSII 123


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 89.4 bits (220), Expect = 9e-18
 Identities = 61/258 (23%), Positives = 108/258 (41%), Gaps = 10/258 (3%)

Query: 326 ARQLHTLAHGEVVCAVTISGSTQHVYTGGKG-CVKVWDVGQPGAKTPVAQLDCLNRDNYI 384
           +R      H + V  V  S S   + +G +   V++W     G  T             +
Sbjct: 14  SRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT-----V 68

Query: 385 RSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCC 444
           RS     DG+S +   +  T+ +W  A    +    L+           SPD ++  S  
Sbjct: 69  RSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 126

Query: 445 SDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 504
            D  + +WD  ++  V  +  H    + +D    GT +   G+DNTV+ WD+R  R LQ 
Sbjct: 127 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 186

Query: 505 HDF-SSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFASCGR 562
           +   S+ +  L   P+ ++L      S ++IL + +    Y LH H+    ++ F+  G 
Sbjct: 187 YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGE 246

Query: 563 WFVSTGKDNLLNAWRTPY 580
           +F S G D  +  W++ +
Sbjct: 247 YFASGGSDEQVMVWKSNF 264



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 34/133 (25%), Positives = 58/133 (43%), Gaps = 2/133 (1%)

Query: 446 DGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLR-EGRQLQQ 504
           D  ++VW ++ Q+   +F GH D  +C++ S  G  L +G  D TVR W    +G     
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 505 HDFSSQIFSLGHCPNQDWLAVGMESSNVEILHV-RKPEKYQLHLHESCVLSLKFASCGRW 563
              ++ + S+  C +        +   V++    R+   + L  H + V   KF+  GR 
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121

Query: 564 FVSTGKDNLLNAW 576
            VS   D  +  W
Sbjct: 122 IVSASDDKTVKLW 134


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 89.4 bits (220), Expect = 9e-18
 Identities = 61/258 (23%), Positives = 108/258 (41%), Gaps = 10/258 (3%)

Query: 326 ARQLHTLAHGEVVCAVTISGSTQHVYTGGKG-CVKVWDVGQPGAKTPVAQLDCLNRDNYI 384
           +R      H + V  V  S S   + +G +   V++W     G  T             +
Sbjct: 52  SRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT-----V 106

Query: 385 RSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCC 444
           RS     DG+S +   +  T+ +W  A    +    L+           SPD ++  S  
Sbjct: 107 RSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 164

Query: 445 SDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 504
            D  + +WD  ++  V  +  H    + +D    GT +   G+DNTV+ WD+R  R LQ 
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224

Query: 505 HDF-SSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFASCGR 562
           +   S+ +  L   P+ ++L      S ++IL + +    Y LH H+    ++ F+  G 
Sbjct: 225 YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGE 284

Query: 563 WFVSTGKDNLLNAWRTPY 580
           +F S G D  +  W++ +
Sbjct: 285 YFASGGSDEQVMVWKSNF 302



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 40/167 (23%), Positives = 74/167 (44%), Gaps = 3/167 (1%)

Query: 455 QNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLR-EGRQLQQHDFSSQIFS 513
           ++ ++ R F+GH D  +C+D S    +L +G +D+ +  W ++ + R  +       +  
Sbjct: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66

Query: 514 LGHCPNQDWLAVGMESSNVEILHVR-KPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNL 572
           +   P+   LA G     V I     K E      H + V S+ F S G+ FV+   D  
Sbjct: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126

Query: 573 LNAWRTPYGASIFQSKESSSVLSC-DISRNNKYIVTGSGDKKATVYE 618
           +  W T     +F   +  + + C   S + + IV+ S DK   +++
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 40/167 (23%), Positives = 68/167 (40%), Gaps = 2/167 (1%)

Query: 412 APTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGAS 471
           A  P ++        A   +  S + K   S   D  ++VW ++ Q+   +F GH D  +
Sbjct: 6   AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65

Query: 472 CIDISDYGTRLWTGGLDNTVRCWDLR-EGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESS 530
           C++ S  G  L +G  D TVR W    +G        ++ + S+  C +        +  
Sbjct: 66  CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125

Query: 531 NVEILHV-RKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAW 576
            V++    R+   + L  H + V   KF+  GR  VS   D  +  W
Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 89.4 bits (220), Expect = 9e-18
 Identities = 61/258 (23%), Positives = 108/258 (41%), Gaps = 10/258 (3%)

Query: 326 ARQLHTLAHGEVVCAVTISGSTQHVYTGGKG-CVKVWDVGQPGAKTPVAQLDCLNRDNYI 384
           +R      H + V  V  S S   + +G +   V++W     G  T             +
Sbjct: 52  SRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT-----V 106

Query: 385 RSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCC 444
           RS     DG+S +   +  T+ +W  A    +    L+           SPD ++  S  
Sbjct: 107 RSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 164

Query: 445 SDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 504
            D  + +WD  ++  V  +  H    + +D    GT +   G+DNTV+ WD+R  R LQ 
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224

Query: 505 HDF-SSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFASCGR 562
           +   S+ +  L   P+ ++L      S ++IL + +    Y LH H+    ++ F+  G 
Sbjct: 225 YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGE 284

Query: 563 WFVSTGKDNLLNAWRTPY 580
           +F S G D  +  W++ +
Sbjct: 285 YFASGGSDEQVMVWKSNF 302



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 40/167 (23%), Positives = 74/167 (44%), Gaps = 3/167 (1%)

Query: 455 QNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLR-EGRQLQQHDFSSQIFS 513
           ++ ++ R F+GH D  +C+D S    +L +G +D+ +  W ++ + R  +       +  
Sbjct: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66

Query: 514 LGHCPNQDWLAVGMESSNVEILHVR-KPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNL 572
           +   P+   LA G     V I     K E      H + V S+ F S G+ FV+   D  
Sbjct: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126

Query: 573 LNAWRTPYGASIFQSKESSSVLSC-DISRNNKYIVTGSGDKKATVYE 618
           +  W T     +F   +  + + C   S + + IV+ S DK   +++
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 40/167 (23%), Positives = 68/167 (40%), Gaps = 2/167 (1%)

Query: 412 APTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGAS 471
           A  P ++        A   +  S + K   S   D  ++VW ++ Q+   +F GH D  +
Sbjct: 6   AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65

Query: 472 CIDISDYGTRLWTGGLDNTVRCWDLR-EGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESS 530
           C++ S  G  L +G  D TVR W    +G        ++ + S+  C +        +  
Sbjct: 66  CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125

Query: 531 NVEILHV-RKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAW 576
            V++    R+   + L  H + V   KF+  GR  VS   D  +  W
Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 63/259 (24%), Positives = 106/259 (40%), Gaps = 10/259 (3%)

Query: 325 HARQLHTLAHGEVVCAVTISGSTQHVYTGGKG-CVKVWDVGQPGAKTPVAQLDCLNRDNY 383
           HAR    + H +VV +V  S     + +  +   V++W   + G  +             
Sbjct: 50  HARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKA-----HTAP 104

Query: 384 IRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSC 443
           +RS     DG+ L    E  ++ +W +     R    L            SPD ++  SC
Sbjct: 105 VRSVDFSADGQFLATASEDKSIKVWSMYRQ--RFLYSLYRHTHWVRCAKFSPDGRLIVSC 162

Query: 444 CSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQ 503
             D  I +WD  N+  V  F      A+ +D +  GT + + G D TV+ WD+R  + LQ
Sbjct: 163 SEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQ 222

Query: 504 QHD-FSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEK-YQLHLHESCVLSLKFASCG 561
            +   S  +  +   P+ ++L        ++IL + +    Y L  H   V ++ F+  G
Sbjct: 223 HYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGG 282

Query: 562 RWFVSTGKDNLLNAWRTPY 580
             F S G D  +  WRT +
Sbjct: 283 ELFASGGADTQVLLWRTNF 301



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 45/212 (21%), Positives = 90/212 (42%), Gaps = 3/212 (1%)

Query: 411 AAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGA 470
           A   P ++        A  +L +SP+ K   +   D  +++W+ +      ++ GH D  
Sbjct: 4   ATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVV 63

Query: 471 SCIDISDYGTRLWTGGLDNTVRCW-DLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMES 529
           + +  S +G  L +   D TVR W   + G+  +    ++ + S+    +  +LA   E 
Sbjct: 64  TSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASED 123

Query: 530 SNVEILHV-RKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSK 588
            ++++  + R+   Y L+ H   V   KF+  GR  VS  +D  +  W T     +    
Sbjct: 124 KSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS 183

Query: 589 ESSSVLS-CDISRNNKYIVTGSGDKKATVYEV 619
           +S    +  D + +   I +   D+   V++V
Sbjct: 184 DSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 73/304 (24%), Positives = 126/304 (41%), Gaps = 21/304 (6%)

Query: 327 RQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLN-RDNYIR 385
           RQ H L  G    A +  G+ Q   T G     +   G P   +  A +  L+  +  + 
Sbjct: 19  RQRHELLLG----AGSGPGAGQQQATPGA----LLQAGPPRCSSLQAPIMLLSGHEGEVY 70

Query: 386 SCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCS 445
            CK  P+G +L   G    + +W++        A L   + A   L  + D  + FS  +
Sbjct: 71  CCKFHPNGSTLASAGFDRLILLWNVYGDCDNY-ATLKGHSGAVMELHYNTDGSMLFSAST 129

Query: 446 DGNIVVWDLQNQTMVRQFQGHTDGA-SCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 504
           D  + VWD +    V++ +GHT    SC         + TG  D TV+ WD+R+   +Q 
Sbjct: 130 DKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT 189

Query: 505 HDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFASCGRW 563
              + Q+ ++      D +  G   +++++  +R+ +  Y +  H   V  L  +S G +
Sbjct: 190 FQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSY 249

Query: 564 FVSTGKDNLLNAWRT-PYG-----ASIFQSKE---SSSVLSCDISRNNKYIVTGSGDKKA 614
            +S   DN +  W   P+        IFQ        ++L C  S +   I  GS D+  
Sbjct: 250 LLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFV 309

Query: 615 TVYE 618
            V++
Sbjct: 310 YVWD 313



 Score = 35.4 bits (80), Expect = 0.16
 Identities = 29/150 (19%), Positives = 60/150 (40%), Gaps = 12/150 (8%)

Query: 324 RHARQLHTLAHGEVVCAVTISGSTQHVYTGG-KGCVKVWDVGQPGAKTPVAQLDCLNRDN 382
           R    + T  +   V AVT + ++  + +GG    +KVWD+ Q      +         +
Sbjct: 182 RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR-----GHAD 236

Query: 383 YIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPR------IKAELTSSAPACYALAVSPD 436
            +    L  +G  L+     +T+ +WD+    P+       +  + +        + SPD
Sbjct: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296

Query: 437 AKVCFSCCSDGNIVVWDLQNQTMVRQFQGH 466
                +  +D  + VWD  ++ ++ +  GH
Sbjct: 297 GSKIAAGSADRFVYVWDTTSRRILYKLPGH 326


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 74/290 (25%), Positives = 116/290 (40%), Gaps = 23/290 (7%)

Query: 334 HGEVVCAVTISGSTQHVYTGGK-GCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 392
           HG  V +   S   Q + TG + GCV  W+         +           ++ C+  PD
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG-----GHTGPVKFCRFSPD 74

Query: 393 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVW 452
           G          T+ +WD+A    +    L     +   ++ SPD++   S   D  +++W
Sbjct: 75  GHLFASASCDCTVRLWDVARA--KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLW 132

Query: 453 DLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIF 512
           D+Q+  M+R   GH D     D S     L TG  D+TV  WDLR       H       
Sbjct: 133 DVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE--- 189

Query: 513 SLGHCPNQDWL---AVGMESSNV--EILHVRKPEK----YQLHLHESCVLSLKFASCGRW 563
             GH  N   L   A G+ +S    + +H+ KP       QL  H + V S+ F+    W
Sbjct: 190 --GHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELW 247

Query: 564 FVSTGKDNLLNAWRTPYGASIFQSKESSSVL-SCDISRNNKYIVTGSGDK 612
             S G   ++  W    G  +   K    V  +C  + + K +V+G+ D+
Sbjct: 248 LASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297



 Score = 31.2 bits (69), Expect = 3.0
 Identities = 36/163 (22%), Positives = 60/163 (36%), Gaps = 3/163 (1%)

Query: 460 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQL-QQHDFSSQIFSLGHCP 518
           V+ F  H    +    S  G  L TG  D  V  W+ R G+ L +    +  +      P
Sbjct: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73

Query: 519 NQDWLAVGMESSNVEILHVRKPEKYQ-LHLHESCVLSLKFASCGRWFVSTGKDNLLNAWR 577
           +    A       V +  V + +  + L  H+  V ++ F+   R   S G D  +  W 
Sbjct: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133

Query: 578 TPYGASI-FQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEV 619
              G  +        S+ S D S     + TGS D    ++++
Sbjct: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 48/202 (23%), Positives = 69/202 (34%), Gaps = 48/202 (23%)

Query: 334 HGEVVCAVTISGSTQHVYTGG-KGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 392
           H   V  V+ S  ++ + +GG    V +WDV Q G    + +L   +RD+ I+S    P 
Sbjct: 104 HQRSVETVSFSPDSRQLASGGWDKRVMLWDV-QSGQ---MLRLLVGHRDS-IQSSDFSPT 158

Query: 393 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPA-----CYA----------------- 430
              L  G   ST+ IWDL   TP +  +      A     CY+                 
Sbjct: 159 VNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIW 218

Query: 431 --------------------LAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGA 470
                               +A SPD     S      + VWD      +   +G  D A
Sbjct: 219 KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVA 278

Query: 471 SCIDISDYGTRLWTGGLDNTVR 492
                +  G  L +G  D T R
Sbjct: 279 HTCAFTPDGKILVSGAADQTRR 300


>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
           isoform a [Homo sapiens]
          Length = 353

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 68/299 (22%), Positives = 126/299 (42%), Gaps = 23/299 (7%)

Query: 334 HG-EVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 392
           HG +V+C        + V +   G V VWD      +  V  + C     ++ +C   P 
Sbjct: 62  HGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVT-MPC----TWVMACAYAPS 116

Query: 393 GRSLIVGGEASTLSIWDLA-------APTPRIKAELTSSAPACYALAVSPDAKVCFSCCS 445
           G ++  GG  +  S++ L        A   +  A  T+   AC     + D ++  +   
Sbjct: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF--TNSDMQI-LTASG 173

Query: 446 DGNIVVWDLQNQTMVRQFQGHTDGASCIDI--SDYGTRLWTGGLDNTVRCWDLREGRQLQ 503
           DG   +WD+++  +++ F GH     C+D+  S+ G    +GG D     WD+R G+ +Q
Sbjct: 174 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 233

Query: 504 QHD-FSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVL---SLKFAS 559
             +   S I S+ + P+ D  A G + +   +  +R   +  ++  ES +    S+ F+ 
Sbjct: 234 AFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSL 293

Query: 560 CGRWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISRNNKYIVTGSGDKKATVY 617
            GR   +   D  +N W    G+ +       + V +  +S +     +GS D    V+
Sbjct: 294 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352


>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
           isoform b [Homo sapiens]
          Length = 395

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 68/299 (22%), Positives = 126/299 (42%), Gaps = 23/299 (7%)

Query: 334 HG-EVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 392
           HG +V+C        + V +   G V VWD      +  V  + C     ++ +C   P 
Sbjct: 104 HGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVT-MPC----TWVMACAYAPS 158

Query: 393 GRSLIVGGEASTLSIWDLA-------APTPRIKAELTSSAPACYALAVSPDAKVCFSCCS 445
           G ++  GG  +  S++ L        A   +  A  T+   AC     + D ++  +   
Sbjct: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF--TNSDMQI-LTASG 215

Query: 446 DGNIVVWDLQNQTMVRQFQGHTDGASCIDI--SDYGTRLWTGGLDNTVRCWDLREGRQLQ 503
           DG   +WD+++  +++ F GH     C+D+  S+ G    +GG D     WD+R G+ +Q
Sbjct: 216 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 275

Query: 504 QHD-FSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVL---SLKFAS 559
             +   S I S+ + P+ D  A G + +   +  +R   +  ++  ES +    S+ F+ 
Sbjct: 276 AFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSL 335

Query: 560 CGRWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISRNNKYIVTGSGDKKATVY 617
            GR   +   D  +N W    G+ +       + V +  +S +     +GS D    V+
Sbjct: 336 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394


>gi|5174447 guanine nucleotide binding protein (G protein), beta
           polypeptide 2-like 1 [Homo sapiens]
          Length = 317

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 65/272 (23%), Positives = 108/272 (39%), Gaps = 20/272 (7%)

Query: 321 GIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGG-KGCVKVWDVGQPGAKTPVAQLDCLN 379
           GIP+ A +     H   V  V IS   Q   +G   G +++WD+      T       + 
Sbjct: 53  GIPQRALR----GHSHFVSDVVISSDGQFALSGSWDGTLRLWDL-----TTGTTTRRFVG 103

Query: 380 RDNYIRSCKLLPDGRSLIVGGEASTLSIWD-LAAPTPRIKAELTSSAPACYALAVSPDAK 438
               + S     D R ++ G    T+ +W+ L      ++ E  S   +C   + +    
Sbjct: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNP 163

Query: 439 VCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLRE 498
           +  SC  D  + VW+L N  +     GHT   + + +S  G+   +GG D     WDL E
Sbjct: 164 IIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE 223

Query: 499 GRQLQQHDFSSQIFSLGHCPNQDWLAVGMESS----NVEILHVRKPEKYQLHLHESCV-- 552
           G+ L   D    I +L   PN+ WL      S    ++E   +    K ++    S    
Sbjct: 224 GKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283

Query: 553 ---LSLKFASCGRWFVSTGKDNLLNAWRTPYG 581
               SL +++ G+   +   DNL+  W+   G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315



 Score = 29.6 bits (65), Expect = 8.6
 Identities = 20/74 (27%), Positives = 34/74 (45%), Gaps = 1/74 (1%)

Query: 548 HESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSK-ESSSVLSCDISRNNKYIV 606
           H   V  +  +S G++ +S   D  L  W    G +  +    +  VLS   S +N+ IV
Sbjct: 62  HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121

Query: 607 TGSGDKKATVYEVV 620
           +GS DK   ++  +
Sbjct: 122 SGSRDKTIKLWNTL 135


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 62/289 (21%), Positives = 110/289 (38%), Gaps = 37/289 (12%)

Query: 366 PGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAE----- 420
           P + T +      N +  + + ++ PD + L  G + S + +W L +   ++K+E     
Sbjct: 253 PPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSK--KLKSEPHQVD 310

Query: 421 ---------------------------LTSSAPACYALAVSPDAKVCFSCCSDGNIVVWD 453
                                      L       Y+     D+    SC  D +I  WD
Sbjct: 311 VSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWD 370

Query: 454 LQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQH-DFSSQIF 512
           L + T    +QGH      +DIS Y     +G  D T R W       L+ +    + + 
Sbjct: 371 LGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVD 430

Query: 513 SLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHL-HESCVLSLKFASCGRWFVSTGKDN 571
            +   PN ++LA G     V +   ++    +L   H   VLSL F+  G++  S G+D 
Sbjct: 431 CVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ 490

Query: 572 LLNAWRTPYGASIFQSK-ESSSVLSCDISRNNKYIVTGSGDKKATVYEV 619
            L  W    G    + +  + ++ S   S ++  I + S D    V+++
Sbjct: 491 RLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 34/126 (26%), Positives = 57/126 (45%), Gaps = 11/126 (8%)

Query: 372 VAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYAL 431
           +A +DC+         K  P+   L  G    T+ +W  +A         T       +L
Sbjct: 426 LADVDCV---------KFHPNSNYLATGSTDKTVRLW--SAQQGNSVRLFTGHRGPVLSL 474

Query: 432 AVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTV 491
           A SP+ K   S   D  + +WDL + T+ ++ +GHTD  + +  S     + +  +DN+V
Sbjct: 475 AFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSV 534

Query: 492 RCWDLR 497
           R WD+R
Sbjct: 535 RVWDIR 540



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 24/73 (32%), Positives = 37/73 (50%), Gaps = 2/73 (2%)

Query: 384 IRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSC 443
           + S    P+G+ L   GE   L +WDLA+ T  +  EL        +L  SPD+ +  S 
Sbjct: 471 VLSLAFSPNGKYLASAGEDQRLKLWDLASGT--LYKELRGHTDNITSLTFSPDSGLIASA 528

Query: 444 CSDGNIVVWDLQN 456
             D ++ VWD++N
Sbjct: 529 SMDNSVRVWDIRN 541


>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
          Length = 404

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 64/277 (23%), Positives = 108/277 (38%), Gaps = 43/277 (15%)

Query: 336 EVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRS 395
           +V C V  +G          G +K+W+V     +T +  L+     + +R     P G  
Sbjct: 120 DVSCLVLATGLND-------GQIKIWEV-----QTGLLLLNLSGHQDVVRDLSFTPSGSL 167

Query: 396 LIVGGEAS-TLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDL 454
           ++V      TL IWDL     +I+  L+      Y  ++SPD  +  S   + ++ +W +
Sbjct: 168 ILVSASRDKTLRIWDLNKHGKQIQV-LSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSM 226

Query: 455 QNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSL 514
           ++ T++R+ +GH       D S     L T   D  V  WD   G +L+         SL
Sbjct: 227 RSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLR---------SL 277

Query: 515 GHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLN 574
            H      +   M+ S+V               H S + S+ F+  G +  +   D LL 
Sbjct: 278 HHTQ----VDPAMDDSDV---------------HISSLRSVCFSPEGLYLATVADDRLLR 318

Query: 575 AWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGD 611
            W       I  +  ++  L C    +   I TG+ D
Sbjct: 319 IWALELKTPIAFAPMTNG-LCCTFFPHGGVIATGTRD 354


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 54/213 (25%), Positives = 92/213 (43%), Gaps = 6/213 (2%)

Query: 404 TLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQF 463
           ++ +W L +  P   A++         +   P  +   + C D +  +WDL+ Q  +   
Sbjct: 304 SVKLWSLDSDEP--VADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQ 361

Query: 464 QGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQ-QHDFSSQIFSLGHCPNQDW 522
           +GH+ G   I     G+   TGGLD   R WDLR GR +        +I+ +   PN   
Sbjct: 362 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYH 421

Query: 523 LAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFASCGRWFVSTGK-DNLLNAWRTPY 580
           +A G   +  ++  +R+    Y +  H++ V  +KF      F+ TG  DN    W  P 
Sbjct: 422 IATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPG 481

Query: 581 GASI-FQSKESSSVLSCDISRNNKYIVTGSGDK 612
            + +   +     V+  DIS + + I T S D+
Sbjct: 482 WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDR 514



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 52/248 (20%), Positives = 78/248 (31%), Gaps = 51/248 (20%)

Query: 381 DNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVC 440
           D  I  C   P+ + L     +    +W +  P   +   L        A+   P + V 
Sbjct: 231 DRPISYCHFSPNSKMLATACWSGLCKLWSV--PDCNLLHTLRGHNTNVGAIVFHPKSTVS 288

Query: 441 F--------SCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVR 492
                    SC +DG++ +W L +   V   +GHT   + +     G  L T   D + R
Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348

Query: 493 CWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCV 552
            WDL                                 +  EILH           H   V
Sbjct: 349 LWDLE--------------------------------AQEEILHQEG--------HSMGV 368

Query: 553 LSLKFASCGRWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISRNNKYIVTGSGD 611
             + F   G    + G D     W    G  I F       +   + S N  +I TGSGD
Sbjct: 369 YDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGD 428

Query: 612 KKATVYEV 619
               V+++
Sbjct: 429 NTCKVWDL 436


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 48/211 (22%), Positives = 92/211 (43%), Gaps = 10/211 (4%)

Query: 332 LAHGEVVCAVTIS-GSTQHVYTGGKGC-VKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKL 389
           +AH   V ++ +   S + + TGG  C V +W + +P        +      + + S +L
Sbjct: 17  VAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCI-----MSLTGHTSPVESVRL 71

Query: 390 LPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNI 449
                 ++ G ++ ++ +WDL A   +I   L        +L   P  +   S   D NI
Sbjct: 72  NTPEELIVAGSQSGSIRVWDLEAA--KILRTLMGHKANICSLDFHPYGEFVASGSQDTNI 129

Query: 450 VVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQH-DFS 508
            +WD++ +  V +++GH+    C+  S  G  L +   D+TV+ WDL  G+ + +    +
Sbjct: 130 KLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189

Query: 509 SQIFSLGHCPNQDWLAVGMESSNVEILHVRK 539
             +  +   PN+  LA G     +    + K
Sbjct: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 34/177 (19%), Positives = 77/177 (43%), Gaps = 3/177 (1%)

Query: 446 DGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ- 504
           D  + +W +     +    GHT     + ++     +  G    ++R WDL   + L+  
Sbjct: 42  DCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTL 101

Query: 505 HDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFASCGRW 563
               + I SL   P  +++A G + +N+++  +R+    ++   H   V  L+F+  G+W
Sbjct: 102 MGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKW 161

Query: 564 FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIV-TGSGDKKATVYEV 619
             S   D+ +  W    G  + +    +  ++      N+Y++ +GS D+    +++
Sbjct: 162 LASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218


>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
           sapiens]
          Length = 340

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 57/249 (22%), Positives = 99/249 (39%), Gaps = 28/249 (11%)

Query: 380 RDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKV 439
           R +++ +C   P G  +  GG  +  SI++L +    +K     SA   Y          
Sbjct: 96  RSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGY---------- 145

Query: 440 CFSCC---SDGNIV---------VWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGL 487
             SCC    D NIV         +WD++       F GHT     + +S       +G  
Sbjct: 146 -LSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGAC 204

Query: 488 DNTVRCWDLREGRQLQQH-DFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLH 546
           D + + WD+REG   Q      S I ++   PN + +  G + ++  +  +R  ++    
Sbjct: 205 DASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICF 264

Query: 547 LHESC---VLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSC-DISRNN 602
            HES    + S+ F+  GR   +   D   N W +     +       + +SC  ++ + 
Sbjct: 265 SHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADG 324

Query: 603 KYIVTGSGD 611
             + TGS D
Sbjct: 325 MAVATGSWD 333



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 50/198 (25%), Positives = 82/198 (41%), Gaps = 7/198 (3%)

Query: 383 YIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFS 442
           Y+  C+ L D   +   G+ +T ++WD+   T + K         C +LAVSPD  +  S
Sbjct: 145 YLSCCRFLDDNNIVTSSGD-TTCALWDIE--TGQQKTVFVGHTGDCMSLAVSPDFNLFIS 201

Query: 443 CCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQL 502
              D +  +WD++  T  + F GH    + I     G  + TG  D + R +DLR  ++L
Sbjct: 202 GACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQEL 261

Query: 503 ---QQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQ-LHLHESCVLSLKFA 558
                      I S+    +   L  G +  N  +    K E+   L  H++ V  L   
Sbjct: 262 ICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVT 321

Query: 559 SCGRWFVSTGKDNLLNAW 576
           + G    +   D+ L  W
Sbjct: 322 ADGMAVATGSWDSFLKIW 339



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 31/137 (22%), Positives = 59/137 (43%), Gaps = 5/137 (3%)

Query: 359 KVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIK 418
           K+WDV +   +           ++ I +    P+G ++  G + ++  ++DL A    I 
Sbjct: 209 KLWDVREGTCRQTFT-----GHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELIC 263

Query: 419 AELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDY 478
               S      ++A S   ++ F+   D N  VWD      V    GH +  SC+ ++  
Sbjct: 264 FSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTAD 323

Query: 479 GTRLWTGGLDNTVRCWD 495
           G  + TG  D+ ++ W+
Sbjct: 324 GMAVATGSWDSFLKIWN 340



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 44/211 (20%), Positives = 76/211 (36%), Gaps = 8/211 (3%)

Query: 416 RIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDI 475
           R +  L       YA+  + D+K+  S   DG ++VWD      V      +        
Sbjct: 46  RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY 105

Query: 476 SDYGTRLWTGGLDNTVRCWDL--REGRQLQQHDFSSQIFSLGHCP--NQDWLAVGMESSN 531
           +  G  +  GGLDN    ++L  REG      + S+    L  C   + + +      + 
Sbjct: 106 APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTT 165

Query: 532 VEILHVRKPEKYQLHL-HESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGA--SIFQSK 588
             +  +   ++  + + H    +SL  +     F+S   D     W    G     F   
Sbjct: 166 CALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGH 225

Query: 589 ESSSVLSCDISRNNKYIVTGSGDKKATVYEV 619
           ES     C    N + I TGS D    ++++
Sbjct: 226 ESDINAIC-FFPNGEAICTGSDDASCRLFDL 255


>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
           sapiens]
          Length = 421

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 64/261 (24%), Positives = 97/261 (37%), Gaps = 43/261 (16%)

Query: 356 GCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEAS-TLSIWDLAAPT 414
           G +K+WDV      T    L+ ++    +R     PDG  ++V      TL +WDL    
Sbjct: 150 GRIKIWDV-----YTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDG 204

Query: 415 PRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCID 474
             +K  L       Y+ A SPD+ +  S  +   + +W++   TM+R+ +GH       D
Sbjct: 205 NMMKV-LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACD 263

Query: 475 ISDYGTRLWTGGLDNTVRCWDLREGRQLQQ--HDF--SSQIFSLGHCPNQDWLAVGMESS 530
            S  G  L T   D  V  WD   G  L +  H F   + IF+ G   N  W        
Sbjct: 264 FSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGG--ANDRW-------- 313

Query: 531 NVEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKES 590
                                V S+ F+  G    S   D ++  WR      + Q    
Sbjct: 314 ---------------------VRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPL 351

Query: 591 SSVLSCDISRNNKYIVTGSGD 611
           S+ L C  S +   +  G+ D
Sbjct: 352 SNGLCCAFSTDGSVLAAGTHD 372



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 36/140 (25%), Positives = 58/140 (41%), Gaps = 9/140 (6%)

Query: 329 LHTLAHGEVVCAVTIS--GSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRS 386
           L+ + H EVV  +T +  GS   V       ++VWD+   G    V +       N++ S
Sbjct: 164 LNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLR----GHQNWVYS 219

Query: 387 CKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSD 446
           C   PD   L   G +  + +W++   T   K E         A   SPD  +  +   D
Sbjct: 220 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE--GHHHDVVACDFSPDGALLATASYD 277

Query: 447 GNIVVWDLQNQTMVRQFQGH 466
             + +WD  N  ++ +F GH
Sbjct: 278 TRVYIWDPHNGDILMEF-GH 296


>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
           [Homo sapiens]
          Length = 340

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 52/239 (21%), Positives = 97/239 (40%), Gaps = 8/239 (3%)

Query: 380 RDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAA--PTPRIKAELTSSAPACYALAVSPDA 437
           R +++ +C   P G  +  GG  +  SI++L       R+  EL              D+
Sbjct: 96  RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDS 155

Query: 438 KVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLR 497
           ++  S   D    +WD++       F GH+     + +S       +G  D + + WD+R
Sbjct: 156 QIVTS-SGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIR 214

Query: 498 EGRQLQQH-DFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESC---VL 553
           +G   Q      S I ++   PN    A G + +   +  +R  ++  L+ H++    + 
Sbjct: 215 DGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGIT 274

Query: 554 SLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSC-DISRNNKYIVTGSGD 611
           S+ F+  GR  ++   D   N W T  G          + +SC  ++ +   + TGS D
Sbjct: 275 SVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 47/198 (23%), Positives = 83/198 (41%), Gaps = 7/198 (3%)

Query: 383 YIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFS 442
           Y+  C+ L D + +   G+ +T ++WD+   T +     T  +    +L++SPD +   S
Sbjct: 145 YLSCCRFLDDSQIVTSSGD-TTCALWDIE--TAQQTTTFTGHSGDVMSLSLSPDMRTFVS 201

Query: 443 CCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQ- 501
              D +  +WD+++    + F GH    + +     G    TG  D T R +DLR  ++ 
Sbjct: 202 GACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQEL 261

Query: 502 -LQQHD-FSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKY-QLHLHESCVLSLKFA 558
            L  HD     I S+    +   L  G +  N  +    K ++   L  H++ V  L   
Sbjct: 262 LLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVT 321

Query: 559 SCGRWFVSTGKDNLLNAW 576
             G    +   D+ L  W
Sbjct: 322 DDGMAVATGSWDSFLRIW 339



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 29/137 (21%), Positives = 57/137 (41%), Gaps = 5/137 (3%)

Query: 359 KVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIK 418
           K+WD+     +  + +       + I +    P+G +   G + +T  ++DL A    + 
Sbjct: 209 KLWDI-----RDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLL 263

Query: 419 AELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDY 478
               +      ++A S   ++  +   D N  VWD           GH +  SC+ ++D 
Sbjct: 264 YSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDD 323

Query: 479 GTRLWTGGLDNTVRCWD 495
           G  + TG  D+ +R W+
Sbjct: 324 GMAVATGSWDSFLRIWN 340



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 39/210 (18%), Positives = 70/210 (33%), Gaps = 6/210 (2%)

Query: 416 RIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDI 475
           R +  L       YA+    D+++  S   DG +++WD      +      +        
Sbjct: 46  RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAY 105

Query: 476 SDYGTRLWTGGLDNTVRCWDL--REGRQLQQHDFSSQIFSLGHCP--NQDWLAVGMESSN 531
           +  G  +  GGLDN    ++L  REG      +       L  C   +   +      + 
Sbjct: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTT 165

Query: 532 VEILHVRKPEKYQLHL-HESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQ-SKE 589
             +  +   ++      H   V+SL  +   R FVS   D     W    G      +  
Sbjct: 166 CALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGH 225

Query: 590 SSSVLSCDISRNNKYIVTGSGDKKATVYEV 619
            S + +     N     TGS D    ++++
Sbjct: 226 VSDINAVSFFPNGYAFATGSDDATCRLFDL 255


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 64/270 (23%), Positives = 103/270 (38%), Gaps = 49/270 (18%)

Query: 392 DGRSLIVGGEA-STLSIWDLAAPT---------------------PRIKAELTSS----- 424
           D  SLI GG A ST+ +W +                          RI  E T+S     
Sbjct: 480 DDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKIL 539

Query: 425 ---APACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTR 481
              +   Y  + SPD     S   DG + +W LQ  T +  ++GH         S YG  
Sbjct: 540 YGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYY 599

Query: 482 LWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHC---------PNQDWLAVGMESSNV 532
             +GG D   R W          H    +IF+ GH          PN +++A G     V
Sbjct: 600 FVSGGHDRVARLW-------ATDHYQPLRIFA-GHLADVNCTRFHPNSNYVATGSADRTV 651

Query: 533 EILHVRKPEKYQLHL-HESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSK-ES 590
            +  V      ++   H+  + SL F+  GR+  +   D  +  W   +G  + + K  +
Sbjct: 652 RLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHT 711

Query: 591 SSVLSCDISRNNKYIVTGSGDKKATVYEVV 620
            +V S   SR+ + + +GS D    +++ +
Sbjct: 712 DTVCSLRFSRDGEILASGSMDNTVRLWDAI 741



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 39/138 (28%), Positives = 66/138 (47%), Gaps = 5/138 (3%)

Query: 391 PDGRSLIVGGEASTLSIWD-LAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNI 449
           P+   +  G    T+ +WD L     RI    T      ++L  SP+ +   +  +DG +
Sbjct: 637 PNSNYVATGSADRTVRLWDVLNGNCVRI---FTGHKGPIHSLTFSPNGRFLATGATDGRV 693

Query: 450 VVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD-LREGRQLQQHDFS 508
           ++WD+ +  MV + +GHTD    +  S  G  L +G +DNTVR WD ++    L+  DF+
Sbjct: 694 LLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFT 753

Query: 509 SQIFSLGHCPNQDWLAVG 526
           +    +    N   L +G
Sbjct: 754 TATGHINLPENSQELLLG 771



 Score = 37.7 bits (86), Expect = 0.032
 Identities = 35/186 (18%), Positives = 74/186 (39%), Gaps = 34/186 (18%)

Query: 469 GASCIDISDYGTRLWTGGLDNTVRCWDL--REGRQLQQ---------------------- 504
           G + +D++D  + +  G  D+TVR W +  ++ R ++Q                      
Sbjct: 472 GLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEK 531

Query: 505 --------HDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHL-HESCVLSL 555
                   +  S  ++     P++++L    E   V +  ++       +  H   V   
Sbjct: 532 TASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDT 591

Query: 556 KFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCD-ISRNNKYIVTGSGDKKA 614
           +F+  G +FVS G D +   W T +   +       + ++C     N+ Y+ TGS D+  
Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTV 651

Query: 615 TVYEVV 620
            +++V+
Sbjct: 652 RLWDVL 657



 Score = 29.6 bits (65), Expect = 8.6
 Identities = 18/70 (25%), Positives = 28/70 (40%), Gaps = 2/70 (2%)

Query: 384 IRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSC 443
           I S    P+GR L  G     + +WD+      +  EL        +L  S D ++  S 
Sbjct: 672 IHSLTFSPNGRFLATGATDGRVLLWDIGHGL--MVGELKGHTDTVCSLRFSRDGEILASG 729

Query: 444 CSDGNIVVWD 453
             D  + +WD
Sbjct: 730 SMDNTVRLWD 739


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,635,826
Number of Sequences: 37866
Number of extensions: 1627155
Number of successful extensions: 8753
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 201
Number of HSP's successfully gapped in prelim test: 525
Number of HSP's that attempted gapping in prelim test: 6487
Number of HSP's gapped (non-prelim): 2074
length of query: 621
length of database: 18,247,518
effective HSP length: 108
effective length of query: 513
effective length of database: 14,157,990
effective search space: 7263048870
effective search space used: 7263048870
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.