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Search of human proteins with 221136858
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221136858 WD repeat domain 79 isoform 2 [Homo sapiens]
(548 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221136866 WD repeat domain 79 isoform 4 [Homo sapiens] 1149 0.0
gi|221136862 WD repeat domain 79 isoform 3 [Homo sapiens] 1149 0.0
gi|221136858 WD repeat domain 79 isoform 2 [Homo sapiens] 1149 0.0
gi|221136854 WD repeat domain 79 isoform 1 [Homo sapiens] 1149 0.0
gi|21071067 TBP-associated factor 5 [Homo sapiens] 74 4e-13
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 64 5e-10
gi|26665869 WD repeat domain 51B [Homo sapiens] 57 6e-08
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 55 2e-07
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 55 2e-07
gi|23199987 WD repeat domain 5B [Homo sapiens] 54 5e-07
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 53 8e-07
gi|113865883 WD repeat domain 38 [Homo sapiens] 52 1e-06
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 52 1e-06
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 51 2e-06
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 51 3e-06
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 50 4e-06
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 50 4e-06
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 50 4e-06
gi|16554629 WD repeat domain 5 [Homo sapiens] 50 5e-06
gi|16554627 WD repeat domain 5 [Homo sapiens] 50 5e-06
gi|32189425 WD repeat domain 69 [Homo sapiens] 50 5e-06
gi|189571685 WD repeat, sterile alpha motif and U-box domain con... 50 7e-06
gi|189571683 WD repeat, sterile alpha motif and U-box domain con... 50 7e-06
gi|189571681 WD repeat, sterile alpha motif and U-box domain con... 50 7e-06
gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens] 49 2e-05
gi|89886480 zinedin isoform 2 [Homo sapiens] 49 2e-05
gi|89886477 zinedin isoform 1 [Homo sapiens] 49 2e-05
gi|16445438 bromodomain and WD repeat domain containing 1 isofor... 48 3e-05
gi|16445436 bromodomain and WD repeat domain containing 1 isofor... 48 3e-05
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 48 3e-05
>gi|221136866 WD repeat domain 79 isoform 4 [Homo sapiens]
Length = 548
Score = 1149 bits (2972), Expect = 0.0
Identities = 548/548 (100%), Positives = 548/548 (100%)
Query: 1 MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60
MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG
Sbjct: 1 MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60
Query: 61 SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120
SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG
Sbjct: 61 SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120
Query: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180
PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD
Sbjct: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180
Query: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240
GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP
Sbjct: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240
Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300
DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV
Sbjct: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300
Query: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL
Sbjct: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD
Sbjct: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
Query: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS
Sbjct: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
Query: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540
GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT
Sbjct: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540
Query: 541 EGGVGELI 548
EGGVGELI
Sbjct: 541 EGGVGELI 548
>gi|221136862 WD repeat domain 79 isoform 3 [Homo sapiens]
Length = 548
Score = 1149 bits (2972), Expect = 0.0
Identities = 548/548 (100%), Positives = 548/548 (100%)
Query: 1 MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60
MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG
Sbjct: 1 MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60
Query: 61 SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120
SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG
Sbjct: 61 SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120
Query: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180
PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD
Sbjct: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180
Query: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240
GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP
Sbjct: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240
Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300
DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV
Sbjct: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300
Query: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL
Sbjct: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD
Sbjct: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
Query: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS
Sbjct: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
Query: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540
GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT
Sbjct: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540
Query: 541 EGGVGELI 548
EGGVGELI
Sbjct: 541 EGGVGELI 548
>gi|221136858 WD repeat domain 79 isoform 2 [Homo sapiens]
Length = 548
Score = 1149 bits (2972), Expect = 0.0
Identities = 548/548 (100%), Positives = 548/548 (100%)
Query: 1 MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60
MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG
Sbjct: 1 MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60
Query: 61 SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120
SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG
Sbjct: 61 SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120
Query: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180
PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD
Sbjct: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180
Query: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240
GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP
Sbjct: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240
Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300
DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV
Sbjct: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300
Query: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL
Sbjct: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD
Sbjct: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
Query: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS
Sbjct: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
Query: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540
GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT
Sbjct: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540
Query: 541 EGGVGELI 548
EGGVGELI
Sbjct: 541 EGGVGELI 548
>gi|221136854 WD repeat domain 79 isoform 1 [Homo sapiens]
Length = 548
Score = 1149 bits (2972), Expect = 0.0
Identities = 548/548 (100%), Positives = 548/548 (100%)
Query: 1 MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60
MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG
Sbjct: 1 MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60
Query: 61 SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120
SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG
Sbjct: 61 SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120
Query: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180
PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD
Sbjct: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180
Query: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240
GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP
Sbjct: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240
Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300
DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV
Sbjct: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300
Query: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL
Sbjct: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD
Sbjct: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
Query: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS
Sbjct: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
Query: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540
GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT
Sbjct: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540
Query: 541 EGGVGELI 548
EGGVGELI
Sbjct: 541 EGGVGELI 548
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 73.6 bits (179), Expect = 4e-13
Identities = 68/275 (24%), Positives = 117/275 (42%), Gaps = 29/275 (10%)
Query: 180 DGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVP------VLRMVEGDT------IY 227
D S I AD+ +R++++ P+ +Q ++ + R+++ T +Y
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILY 540
Query: 228 DYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSP 287
+ +S PD +Y+ SSS + + +W T ++ +N+ FSP
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNY-----PVWDTQFSP 595
Query: 288 DGSQLFCG-FNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYG 346
G G +R R+++T + FA G ++C F P A GS
Sbjct: 596 YGYYFVSGGHDRVARLWATDH----YQPLRIFA---GHLADVNCTRFHPNSNYVATGSAD 648
Query: 347 RSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWS 406
R++ L+ +G+ + + GH+G I L F P+G RF + D +L WD+ G +
Sbjct: 649 RTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNG-RFLATGATDGRVLLWDIGH-GLMVGE 706
Query: 407 LGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
L T + F D G+ L SGS V +WD
Sbjct: 707 LKGHTDTVCSLRFSRD--GEILASGSMDNTVRLWD 739
Score = 40.4 bits (93), Expect = 0.004
Identities = 34/135 (25%), Positives = 47/135 (34%), Gaps = 28/135 (20%)
Query: 358 SPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQ---------SGYPLWSLG 408
S L +L GH G + F PD N S + +D + W L+ YP+W
Sbjct: 534 SELKILYGHSGPVYGASFSPDRNYLLSSS-EDGTVRLWSLQTFTCLVGYKGHNYPVWDT- 591
Query: 409 REVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVS 468
P G + VSG +W TD +P+ F N
Sbjct: 592 -----------QFSPYGYYFVSGGHDRVARLWATD------HYQPLRIFAGHLADVNCTR 634
Query: 469 LHPSLPLLATASGQR 483
HP+ +AT S R
Sbjct: 635 FHPNSNYVATGSADR 649
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 63.5 bits (153), Expect = 5e-10
Identities = 68/292 (23%), Positives = 122/292 (41%), Gaps = 40/292 (13%)
Query: 169 ENFLKGCKWAPDGSCILTNSADNILRIYNL-PPELYHEGEQVEYAEMVPVLRMVEGDTIY 227
E L + +PD + ++ +++++L +L E QV+ + + ++E +
Sbjct: 268 EQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDE 327
Query: 228 D------------YCWYSLMSSAQPDTSYVASSSRENPIHIWD--AFTGELRASFRAYNH 273
D +C + D+S + S S + I WD +FT + AY
Sbjct: 328 DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV 387
Query: 274 LDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTARPGRDCEVRATFAKK--QGQSGIISCI 331
D + +SL F+ GS +RT R++S R T+ + G + C+
Sbjct: 388 WDLDISPYSLYFA-SGSH-----DRTARLWSFDR---------TYPLRIYAGHLADVDCV 432
Query: 332 AFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAE 391
F P A GS +++ L++ G+ + L GH+G + L F P+G ++ + A +D
Sbjct: 433 KFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG-KYLASAGEDQR 491
Query: 392 LLCWDLRQSGYPLWSLGREVT--TNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
L WDL +L +E+ T+ P + S S +V VWD
Sbjct: 492 LKLWDLASG-----TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 56.6 bits (135), Expect = 6e-08
Identities = 59/266 (22%), Positives = 108/266 (40%), Gaps = 36/266 (13%)
Query: 159 GSWSEFSTQPENFLKGCKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVL 218
G +SEF ++ ++ DG + T S D ++++++ + +
Sbjct: 93 GKFSEFKAHTAP-VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLY------------- 138
Query: 219 RMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELT 278
++Y + + + PD + S S + I IWD + +F D +
Sbjct: 139 ------SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS-----DSVG 187
Query: 279 AAHSLCFSPDGSQLF-CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQ 337
A+ + F+P G+ + G ++TV+V+ D V Q SG ++CI+F P+
Sbjct: 188 FANFVDFNPSGTCIASAGSDQTVKVW-------DVRVNKLLQHYQVHSGGVNCISFHPSG 240
Query: 338 PLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDL 397
S +L + +G + L GH G + + F G F SG D ++L W
Sbjct: 241 NYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGG-ADTQVLLW-- 297
Query: 398 RQSGYPLWSLGREVTTNQRIYFDLDP 423
R + L G +R++FD P
Sbjct: 298 RTNFDELHCKGLTKRNLKRLHFDSPP 323
Score = 45.1 bits (105), Expect = 2e-04
Identities = 58/255 (22%), Positives = 98/255 (38%), Gaps = 49/255 (19%)
Query: 240 PDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGF-NR 298
P+ +A++S + + +W+ + RAY ++ S+ FSP G+ L +R
Sbjct: 28 PNGKQLATASWDTFLMLWN-----FKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDR 82
Query: 299 TVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGS 358
TVR++ + G+ E +A A + + FS A S +S+ +++
Sbjct: 83 TVRLWIPDKRGKFSEFKAHTAP-------VRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
Query: 359 PLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRI- 417
L L H + F PDG R +D + WD TTN++
Sbjct: 136 FLYSLYRHTHWVRCAKFSPDG-RLIVSCSEDKTIKIWD---------------TTNKQCV 179
Query: 418 -----------YFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLS-FLPQKDCTN 465
+ D +P+G + S + V VWD + +L + N
Sbjct: 180 NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV-------RVNKLLQHYQVHSGGVN 232
Query: 466 GVSLHPSLPLLATAS 480
+S HPS L TAS
Sbjct: 233 CISFHPSGNYLITAS 247
Score = 32.7 bits (73), Expect = 0.88
Identities = 30/119 (25%), Positives = 49/119 (41%), Gaps = 4/119 (3%)
Query: 322 QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNR 381
+G I+ + SP A S+ L L+ + + GH+ +T + F P GN
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN- 73
Query: 382 FFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVW 440
+ A +D + W + G +S + T R D GQFL + S ++ VW
Sbjct: 74 LLASASRDRTVRLWIPDKRG--KFSEFKAHTAPVR-SVDFSADGQFLATASEDKSIKVW 129
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 54.7 bits (130), Expect = 2e-07
Identities = 49/192 (25%), Positives = 73/192 (38%), Gaps = 31/192 (16%)
Query: 306 ARPGRDCEVRATFAKKQ-------GQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGS 358
A G DC V K G + + + + + L GS S+ ++ +
Sbjct: 37 ATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAK 96
Query: 359 PLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIY 418
L L GH+ I L FHP G F + +D + WD+R+ G G
Sbjct: 97 ILRTLMGHKANICSLDFHPYGE-FVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR---C 152
Query: 419 FDLDPTGQFLVSGSTSGAVSVWD-------TDGPGNDGKPEPVLSFLPQKDCTNGVSLHP 471
P G++L S + V +WD ++ PG+ G PV N V HP
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG---PV----------NVVEFHP 199
Query: 472 SLPLLATASGQR 483
+ LLA+ S R
Sbjct: 200 NEYLLASGSSDR 211
Score = 54.7 bits (130), Expect = 2e-07
Identities = 50/206 (24%), Positives = 85/206 (41%), Gaps = 23/206 (11%)
Query: 197 NLPPELYHEGEQ-----VEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRE 251
N P EL G Q V E +LR + G + C P +VAS S++
Sbjct: 72 NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA-NICSLDF----HPYGEFVASGSQD 126
Query: 252 NPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFN-RTVRVFSTARPGR 310
I +WD +R + + A L FSPDG L + TV+++
Sbjct: 127 TNIKLWD-----IRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLW------- 174
Query: 311 DCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGI 370
D ++ G +G ++ + F P + L A GS R++ + + ++ + G G +
Sbjct: 175 DLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPV 234
Query: 371 THLCFHPDGNRFFSGARKDAELLCWD 396
+ F+PDG +SG + + W+
Sbjct: 235 RSVLFNPDGCCLYSGCQDSLRVYGWE 260
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 54.7 bits (130), Expect = 2e-07
Identities = 87/357 (24%), Positives = 132/357 (36%), Gaps = 87/357 (24%)
Query: 133 SGEPAAEDEGDTA---WNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPDGSCILTNSA 189
+G+ A GDT W+ S ++ P F +++ W+PDG + +
Sbjct: 125 TGKYLASGSGDTTVRFWDLS-TETPHFTCKGH-------RHWVLSISWSPDGRKLASGCK 176
Query: 190 DNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDT--IYDYCWYSLMSSAQPDTSYVAS 247
+ + +++ G+QV R + G + I W L A P+ YVAS
Sbjct: 177 NGQILLWDPST-----GKQVG--------RTLAGHSKWITGLSWEPL--HANPECRYVAS 221
Query: 248 SSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTAR 307
SS++ + IWD G R H +T L + DG +RT++V+ A
Sbjct: 222 SSKDGSVRIWDTTAG--RCERILTGHTQSVTC---LRWGGDGLLYSASQDRTIKVW-RAH 275
Query: 308 PGRDCEVRATFAKKQGQSGIISCI-----------AFSPAQPLY---------------A 341
G C QG ++ + AF PA+ A
Sbjct: 276 DGVLCRT------LQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERA 329
Query: 342 CGSYGRSLG--------------LYAW---DDGSPLALLGGHQGGITHLCFHPDGNRFFS 384
Y G L+ W +D PL + GHQ I + F PD +R +
Sbjct: 330 LSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD-SRIVA 388
Query: 385 GARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
A D + WD R Y L SL V +I + D + LVSGS+ + VWD
Sbjct: 389 SASFDKSIKLWDGRTGKY-LASLRGHVAAVYQIAWSAD--SRLLVSGSSDSTLKVWD 442
Score = 51.2 bits (121), Expect = 2e-06
Identities = 33/124 (26%), Positives = 57/124 (45%), Gaps = 4/124 (3%)
Query: 322 QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNR 381
+G S + +AFSP A GS ++ + +P GH+ + + + PDG +
Sbjct: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK 170
Query: 382 FFSGARKDAELLCWDL---RQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVS 438
SG K+ ++L WD +Q G L + +T +P +++ S S G+V
Sbjct: 171 LASGC-KNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229
Query: 439 VWDT 442
+WDT
Sbjct: 230 IWDT 233
Score = 47.8 bits (112), Expect = 3e-05
Identities = 31/128 (24%), Positives = 54/128 (42%), Gaps = 4/128 (3%)
Query: 313 EVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITH 372
E + + G +I+ + FSP + A S+ +S+ L+ G LA L GH +
Sbjct: 360 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
Query: 373 LCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGS 432
+ + D SG+ D+ L WD++ + G ++ D P GQ + SG
Sbjct: 420 IAWSADSRLLVSGS-SDSTLKVWDVKAQKLAMDLPGH---ADEVYAVDWSPDGQRVASGG 475
Query: 433 TSGAVSVW 440
+ +W
Sbjct: 476 KDKCLRIW 483
Score = 35.8 bits (81), Expect = 0.10
Identities = 32/117 (27%), Positives = 50/117 (42%), Gaps = 19/117 (16%)
Query: 216 PVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLD 275
P+ RM + + +S PD+ VAS+S + I +WD TG+ AS R +
Sbjct: 364 PLTRMTGHQALINQVLFS------PDSRIVASASFDKSIKLWDGRTGKYLASLRGH---- 413
Query: 276 ELTAAHSLCFSPDGSQLFCG-FNRTVRVFSTAR-------PGRDCEVRATFAKKQGQ 324
+ A + + +S D L G + T++V+ PG EV A GQ
Sbjct: 414 -VAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ 469
Score = 35.0 bits (79), Expect = 0.18
Identities = 39/162 (24%), Positives = 63/162 (38%), Gaps = 19/162 (11%)
Query: 240 PDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGF-NR 298
P Y+AS S + + WD T + + + H S+ +SPDG +L G N
Sbjct: 124 PTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHW-----VLSISWSPDGRKLASGCKNG 178
Query: 299 TVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYAC---GSYGRSLGLYAWD 355
+ ++ P +V T A G S I+ +++ P C S + + WD
Sbjct: 179 QILLWD---PSTGKQVGRTLA---GHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232
Query: 356 D--GSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCW 395
G +L GH +T C G+ A +D + W
Sbjct: 233 TTAGRCERILTGHTQSVT--CLRWGGDGLLYSASQDRTIKVW 272
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 53.5 bits (127), Expect = 5e-07
Identities = 48/203 (23%), Positives = 88/203 (43%), Gaps = 16/203 (7%)
Query: 240 PDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRT 299
P+ ++ASSS + I IW A+ G+ + Y H E++ + +S D S+L +
Sbjct: 51 PNGEWLASSSADRLIIIWGAYDGKYEKTL--YGHNLEIS---DVAWSSDSSRLVSASDDK 105
Query: 300 VRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSP 359
R G+ + +G S + C F+P L GS+ ++ ++ G
Sbjct: 106 TLKLWDVRSGKCLKTL------KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159
Query: 360 LALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYF 419
L L H ++ + F+ G+ SG+ D WD SG L +L + N + F
Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGS-YDGLCRIWD-AASGQCLKTLVDD--DNPPVSF 215
Query: 420 -DLDPTGQFLVSGSTSGAVSVWD 441
P G+++++ + + +WD
Sbjct: 216 VKFSPNGKYILTATLDNTLKLWD 238
Score = 48.5 bits (114), Expect = 2e-05
Identities = 66/310 (21%), Positives = 126/310 (40%), Gaps = 46/310 (14%)
Query: 176 KWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLM 235
K++P+G + ++SAD ++ I+ Y E+ Y + I D W S
Sbjct: 48 KFSPNGEWLASSSADRLIIIWGAYDGKY---EKTLYGHNL---------EISDVAWSS-- 93
Query: 236 SSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLC--FSPDGSQLF 293
D+S + S+S + + +WD +G+ + + +++ + C F+P + +
Sbjct: 94 -----DSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSN-------YVFCCNFNPPSNLII 141
Query: 294 CG-FNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLY 352
G F+ TV+++ + + S +S + F+ + L GSY ++
Sbjct: 142 SGSFDETVKIW-------EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Query: 353 AWDDGSPL-ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREV 411
G L L+ ++ + F P+G ++ A D L WD + G L +
Sbjct: 195 DAASGQCLKTLVDDDNPPVSFVKFSPNG-KYILTATLDNTLKLWDYSR-GRCLKTYTGHK 252
Query: 412 TTNQRIYFDLDPT-GQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLH 470
I+ + T G+++VSGS V +W N E V D + H
Sbjct: 253 NEKYCIFANFSVTGGKWIVSGSEDNLVYIW------NLQTKEIVQKLQGHTDVVISAACH 306
Query: 471 PSLPLLATAS 480
P+ L+A+A+
Sbjct: 307 PTENLIASAA 316
Score = 42.7 bits (99), Expect = 9e-04
Identities = 38/141 (26%), Positives = 62/141 (43%), Gaps = 7/141 (4%)
Query: 304 STARPGRDCEVRATFAKK---QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
S+A ++ +A K G + +S + FSP A S R + ++ DG
Sbjct: 17 SSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE 76
Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
L GH I+ + + D +R S A D L WD+R SG L +L + +N +
Sbjct: 77 KTLYGHNLEISDVAWSSDSSRLVS-ASDDKTLKLWDVR-SGKCLKTL--KGHSNYVFCCN 132
Query: 421 LDPTGQFLVSGSTSGAVSVWD 441
+P ++SGS V +W+
Sbjct: 133 FNPPSNLIISGSFDETVKIWE 153
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 52.8 bits (125), Expect = 8e-07
Identities = 43/158 (27%), Positives = 67/158 (42%), Gaps = 14/158 (8%)
Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNR-- 298
D +A+ I IWD +TG+L N +D L F+PDGS + +R
Sbjct: 139 DQLLLATGLNNGRIKIWDVYTGKL-----LLNLVDHTEVVRDLTFAPDGSLILVSASRDK 193
Query: 299 TVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGS 358
T+RV+ G +V + Q+ + SC AFSP + +++ L+ D +
Sbjct: 194 TLRVWDLKDDGNMMKVL-----RGHQNWVYSC-AFSPDSSMLCSVGASKAVFLWNMDKYT 247
Query: 359 PLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWD 396
+ L GH + F PDG + A D + WD
Sbjct: 248 MIRKLEGHHHDVVACDFSPDG-ALLATASYDTRVYIWD 284
Score = 37.0 bits (84), Expect = 0.047
Identities = 30/113 (26%), Positives = 45/113 (39%), Gaps = 6/113 (5%)
Query: 333 FSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAEL 392
F Q L A G + ++ G L L H + L F PDG+ A +D L
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 393 LCWDLRQSGYPLWSLGREVTTNQRIYFD--LDPTGQFLVSGSTSGAVSVWDTD 443
WDL+ G ++ + + +Q + P L S S AV +W+ D
Sbjct: 196 RVWDLKDDG----NMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMD 244
Score = 32.0 bits (71), Expect = 1.5
Identities = 22/103 (21%), Positives = 48/103 (46%), Gaps = 25/103 (24%)
Query: 169 ENFLKGCKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEG---DT 225
+N++ C ++PD S + + A + ++N+ + ++R +EG D
Sbjct: 214 QNWVYSCAFSPDSSMLCSVGASKAVFLWNM--------------DKYTMIRKLEGHHHDV 259
Query: 226 IYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASF 268
+ C +S PD + +A++S + ++IWD G++ F
Sbjct: 260 VA--CDFS------PDGALLATASYDTRVYIWDPHNGDILMEF 294
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 52.0 bits (123), Expect = 1e-06
Identities = 47/161 (29%), Positives = 66/161 (40%), Gaps = 10/161 (6%)
Query: 281 HSLCFSPDGSQLFCGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLY 340
+S FSPDG L G R G+ + G +G + FSP L+
Sbjct: 25 NSSAFSPDGQMLLTGSEDGCVYGWETRSGQ------LLWRLGGHTGPVKFCRFSPDGHLF 78
Query: 341 ACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQS 400
A S ++ L+ L +L GHQ + + F PD + SG D ++ WD+ QS
Sbjct: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGG-WDKRVMLWDV-QS 136
Query: 401 GYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
G L L + Q D PT L +GS V +WD
Sbjct: 137 GQMLRLLVGHRDSIQS--SDFSPTVNCLATGSWDSTVHIWD 175
Score = 50.8 bits (120), Expect = 3e-06
Identities = 78/339 (23%), Positives = 135/339 (39%), Gaps = 53/339 (15%)
Query: 101 NTSLPAEEANGSLSEEEANGPELGSGKAMEDTSGEPAAEDEGDT-AWNYSFSQLPRFLSG 159
N+ +PA A + +G E+ S D ++G W QL L G
Sbjct: 2 NSGVPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGG 61
Query: 160 SWSEFSTQPENFLKGCKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLR 219
T P F C+++PDG + S D +R++++ LR
Sbjct: 62 H-----TGPVKF---CRFSPDGHLFASASCDCTVRLWDV--------------ARAKCLR 99
Query: 220 MVEG-----DTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHL 274
+++G +T+ S PD+ +AS + + +WD +G++ H
Sbjct: 100 VLKGHQRSVETV----------SFSPDSRQLASGGWDKRVMLWDVQSGQMLRLL--VGHR 147
Query: 275 DELTAAHSLCFSPDGSQLFCG-FNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAF 333
D + ++ FSP + L G ++ TV ++ R + +G S ISC+ +
Sbjct: 148 DSIQSSD---FSPTVNCLATGSWDSTVHIWDL----RMVTPAVSHQALEGHSANISCLCY 200
Query: 334 SPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELL 393
S A L A GS+ +++ ++ S L L GH + + F PD + + A +
Sbjct: 201 S-ASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD-ELWLASAGYSRMVK 258
Query: 394 CWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGS 432
WD +G L +L + F P G+ LVSG+
Sbjct: 259 VWDC-NTGKCLETLKGVLDVAHTCAF--TPDGKILVSGA 294
Score = 42.0 bits (97), Expect = 0.001
Identities = 39/157 (24%), Positives = 61/157 (38%), Gaps = 14/157 (8%)
Query: 326 GIISCIAFSPAQPLYACGSYGRSLGLYAWD--DGSPLALLGGHQGGITHLCFHPDGNRFF 383
G ++ AFSP + GS + Y W+ G L LGGH G + F PDG+ F
Sbjct: 22 GEVNSSAFSPDGQMLLTGSEDGCV--YGWETRSGQLLWRLGGHTGPVKFCRFSPDGH-LF 78
Query: 384 SGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDTD 443
+ A D + WD+ ++ G + + P + L SG V +WD
Sbjct: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVET---VSFSPDSRQLASGGWDKRVMLWDVQ 135
Query: 444 GPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
+ + + +D P++ LAT S
Sbjct: 136 ------SGQMLRLLVGHRDSIQSSDFSPTVNCLATGS 166
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 52.0 bits (123), Expect = 1e-06
Identities = 42/160 (26%), Positives = 60/160 (37%), Gaps = 8/160 (5%)
Query: 322 QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWD-DGSPLALLGGHQGGITHLCFHPDGN 380
+ S I CIA P QP S + L+ WD S + GH + + +P N
Sbjct: 96 EAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDN 155
Query: 381 RFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVW 440
F+ A D + W L S G E N Y+ +L+SG+ V +W
Sbjct: 156 NQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYS-GGDKPYLISGADDRLVKIW 214
Query: 441 DTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
D N + + C S HP LP++ T S
Sbjct: 215 DYQ---NKTCVQTLEGHAQNVSC---ASFHPELPIIITGS 248
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 51.2 bits (121), Expect = 2e-06
Identities = 60/288 (20%), Positives = 100/288 (34%), Gaps = 78/288 (27%)
Query: 161 WSEFSTQP-------ENFLKGCKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAE 213
W ++T +++ C +AP G+ + DNI IYNL EG
Sbjct: 82 WDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT---REGN------ 132
Query: 214 MVPVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNH 273
V V R + G T Y C L D + + +SS + +WD TG+ +F +
Sbjct: 133 -VRVSRELAGHTGYLSCCRFL------DDNQIVTSSGDTTCALWDIETGQQTTTFTGH-- 183
Query: 274 LDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAF 333
+G + ++
Sbjct: 184 ---------------------------------------------------TGDVMSLSL 192
Query: 334 SPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELL 393
+P L+ G+ S L+ +G GH+ I +CF P+GN F +G+ DA
Sbjct: 193 APDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGS-DDATCR 251
Query: 394 CWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
+DLR + L + + +G+ L++G +VWD
Sbjct: 252 LFDLR-ADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 50.8 bits (120), Expect = 3e-06
Identities = 75/334 (22%), Positives = 117/334 (35%), Gaps = 80/334 (23%)
Query: 137 AAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENF------LKGCK-------WAPDG-S 182
A+ED W+Y R L G S Q +F L C W G
Sbjct: 126 ASEDATIKVWDYETGDFERTLKGHTD--SVQDISFDHSGKLLASCSADMTIKLWDFQGFE 183
Query: 183 CILTNSAD--NILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYC---------W 231
CI T N+ + +P G+ + A ++M E T YC W
Sbjct: 184 CIRTMHGHDHNVSSVAIMP-----NGDHIVSASRDKTIKMWEVQT--GYCVKTFTGHREW 236
Query: 232 YSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQ 291
++ Q D + +AS S + + +W T E +A R + H+ E + ++P+ S
Sbjct: 237 VRMVRPNQ-DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE-----CISWAPESS- 289
Query: 292 LFCGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGL 351
+S+ E + KK G+ G P GS +++ +
Sbjct: 290 -----------YSSI-----SEATGSETKKSGKPG-----------PFLLSGSRDKTIKM 322
Query: 352 YAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREV 411
+ G L L GH + + FH G +F D L WD +
Sbjct: 323 WDVSTGMCLMTLVGHDNWVRGVLFH-SGGKFILSCADDKTLRVWDYKNKRC-------MK 374
Query: 412 TTNQRIYF----DLDPTGQFLVSGSTSGAVSVWD 441
T N +F D T ++V+GS V VW+
Sbjct: 375 TLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 36.2 bits (82), Expect = 0.080
Identities = 25/82 (30%), Positives = 38/82 (46%), Gaps = 4/82 (4%)
Query: 363 LGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLD 422
L GH+ +T + FHP + S A +DA + WD + +L + Q I F D
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVS-ASEDATIKVWDYETGDFER-TLKGHTDSVQDISF--D 159
Query: 423 PTGQFLVSGSTSGAVSVWDTDG 444
+G+ L S S + +WD G
Sbjct: 160 HSGKLLASCSADMTIKLWDFQG 181
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 50.4 bits (119), Expect = 4e-06
Identities = 59/244 (24%), Positives = 92/244 (37%), Gaps = 29/244 (11%)
Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGF-NRT 299
+T +AS S ++ + +W ++ RAY A + FSP G L G ++T
Sbjct: 30 NTKQLASGSMDSCLMVW-----HMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKT 84
Query: 300 VRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSP 359
VR++ G RA + + + F + S +++ ++A
Sbjct: 85 VRIWVPNVKGESTVFRA-------HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137
Query: 360 LALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDL--RQSGYPLWSLGREVTTNQRI 417
L L H + F PDG R A D + WD R+ + G VT
Sbjct: 138 LFSLSQHINWVRCAKFSPDG-RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT----- 191
Query: 418 YFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLS-FLPQKDCTNGVSLHPSLPLL 476
Y D P+G + + V VWD + +L + NG+S HPS L
Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDV-------RTHRLLQHYQLHSAAVNGLSFHPSGNYL 244
Query: 477 ATAS 480
TAS
Sbjct: 245 ITAS 248
Score = 41.6 bits (96), Expect = 0.002
Identities = 37/157 (23%), Positives = 62/157 (39%), Gaps = 14/157 (8%)
Query: 240 PDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFC-GFNR 298
PD + S+S + + +WD + E S+ + H P G+ + G +
Sbjct: 155 PDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH-----PSGTCIAAAGMDN 209
Query: 299 TVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGS 358
TV+V+ D Q S ++ ++F P+ S +L + +G
Sbjct: 210 TVKVW-------DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGR 262
Query: 359 PLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCW 395
L L GHQG T + F G F SG D +++ W
Sbjct: 263 LLYTLHGHQGPATTVAFSRTGEYFASGG-SDEQVMVW 298
Score = 39.7 bits (91), Expect = 0.007
Identities = 56/268 (20%), Positives = 107/268 (39%), Gaps = 36/268 (13%)
Query: 177 WAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMS 236
++P G + + S D +RI+ P + +GE + +R V +C
Sbjct: 69 FSPSGHLLASGSRDKTVRIW--VPNV--KGESTVFRAHTATVRSVH------FC------ 112
Query: 237 SAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGF 296
D ++S + + +W T + F H++ + A FSPDG +
Sbjct: 113 ---SDGQSFVTASDDKTVKVWA--THRQKFLFSLSQHINWVRCAK---FSPDGRLIVSAS 164
Query: 297 N-RTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWD 355
+ +TV+++ + R+C ++ + G ++ + F P+ A ++ ++
Sbjct: 165 DDKTVKLWD--KSSRECV--HSYCE---HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 356 DGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQ 415
L H + L FHP GN + A D+ L DL + G L++L
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLIT-ASSDSTLKILDLME-GRLLYTLHGHQGPAT 275
Query: 416 RIYFDLDPTGQFLVSGSTSGAVSVWDTD 443
+ F TG++ SG + V VW ++
Sbjct: 276 TVAFSR--TGEYFASGGSDEQVMVWKSN 301
Score = 36.6 bits (83), Expect = 0.061
Identities = 32/121 (26%), Positives = 48/121 (39%), Gaps = 4/121 (3%)
Query: 322 QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNR 381
+G ++C+ FS A GS L ++ S GH+ +T + F P G+
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 382 FFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
SG+R D + W G T + ++F D GQ V+ S V VW
Sbjct: 76 LASGSR-DKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSD--GQSFVTASDDKTVKVWA 131
Query: 442 T 442
T
Sbjct: 132 T 132
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 50.4 bits (119), Expect = 4e-06
Identities = 59/244 (24%), Positives = 92/244 (37%), Gaps = 29/244 (11%)
Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGF-NRT 299
+T +AS S ++ + +W ++ RAY A + FSP G L G ++T
Sbjct: 30 NTKQLASGSMDSCLMVW-----HMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKT 84
Query: 300 VRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSP 359
VR++ G RA + + + F + S +++ ++A
Sbjct: 85 VRIWVPNVKGESTVFRA-------HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137
Query: 360 LALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDL--RQSGYPLWSLGREVTTNQRI 417
L L H + F PDG R A D + WD R+ + G VT
Sbjct: 138 LFSLSQHINWVRCAKFSPDG-RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT----- 191
Query: 418 YFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLS-FLPQKDCTNGVSLHPSLPLL 476
Y D P+G + + V VWD + +L + NG+S HPS L
Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDV-------RTHRLLQHYQLHSAAVNGLSFHPSGNYL 244
Query: 477 ATAS 480
TAS
Sbjct: 245 ITAS 248
Score = 41.6 bits (96), Expect = 0.002
Identities = 37/157 (23%), Positives = 62/157 (39%), Gaps = 14/157 (8%)
Query: 240 PDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFC-GFNR 298
PD + S+S + + +WD + E S+ + H P G+ + G +
Sbjct: 155 PDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH-----PSGTCIAAAGMDN 209
Query: 299 TVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGS 358
TV+V+ D Q S ++ ++F P+ S +L + +G
Sbjct: 210 TVKVW-------DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGR 262
Query: 359 PLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCW 395
L L GHQG T + F G F SG D +++ W
Sbjct: 263 LLYTLHGHQGPATTVAFSRTGEYFASGG-SDEQVMVW 298
Score = 39.7 bits (91), Expect = 0.007
Identities = 56/268 (20%), Positives = 107/268 (39%), Gaps = 36/268 (13%)
Query: 177 WAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMS 236
++P G + + S D +RI+ P + +GE + +R V +C
Sbjct: 69 FSPSGHLLASGSRDKTVRIW--VPNV--KGESTVFRAHTATVRSVH------FC------ 112
Query: 237 SAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGF 296
D ++S + + +W T + F H++ + A FSPDG +
Sbjct: 113 ---SDGQSFVTASDDKTVKVWA--THRQKFLFSLSQHINWVRCAK---FSPDGRLIVSAS 164
Query: 297 N-RTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWD 355
+ +TV+++ + R+C ++ + G ++ + F P+ A ++ ++
Sbjct: 165 DDKTVKLWD--KSSRECV--HSYCE---HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 356 DGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQ 415
L H + L FHP GN + A D+ L DL + G L++L
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLIT-ASSDSTLKILDLME-GRLLYTLHGHQGPAT 275
Query: 416 RIYFDLDPTGQFLVSGSTSGAVSVWDTD 443
+ F TG++ SG + V VW ++
Sbjct: 276 TVAFSR--TGEYFASGGSDEQVMVWKSN 301
Score = 36.6 bits (83), Expect = 0.061
Identities = 32/121 (26%), Positives = 48/121 (39%), Gaps = 4/121 (3%)
Query: 322 QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNR 381
+G ++C+ FS A GS L ++ S GH+ +T + F P G+
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 382 FFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
SG+R D + W G T + ++F D GQ V+ S V VW
Sbjct: 76 LASGSR-DKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSD--GQSFVTASDDKTVKVWA 131
Query: 442 T 442
T
Sbjct: 132 T 132
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 50.4 bits (119), Expect = 4e-06
Identities = 67/292 (22%), Positives = 109/292 (37%), Gaps = 44/292 (15%)
Query: 161 WSEFSTQP-------ENFLKGCKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAE 213
W ++T +++ C +AP G+ + DNI IY+L EG
Sbjct: 82 WDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKT---REGN------ 132
Query: 214 MVPVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNH 273
V V R + G T Y C L D + + +SS + +WD TG+ F ++
Sbjct: 133 -VRVSRELPGHTGYLSCCRFL------DDNQIITSSGDTTCALWDIETGQQTVGFAGHS- 184
Query: 274 LDELTAAHSLCFSPDGSQLFCG-FNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIA 332
SL +PDG G + +++++ RD R TF G I+ +A
Sbjct: 185 ----GDVMSLSLAPDGRTFVSGACDASIKLWDV----RDSMCRQTFI---GHESDINAVA 233
Query: 333 FSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQG---GITHLCFHPDGNRFFSGARKD 389
F P + GS + L+ L L+ H GIT + F G +G D
Sbjct: 234 FFPNGYAFTTGSDDATCRLFDLRADQEL-LMYSHDNIICGITSVAFSRSGRLLLAG-YDD 291
Query: 390 AELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
WD + G + N+ + G + +GS + +W+
Sbjct: 292 FNCNIWDAMKGDRAGVLAGHD---NRVSCLGVTDDGMAVATGSWDSFLKIWN 340
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 50.1 bits (118), Expect = 5e-06
Identities = 45/204 (22%), Positives = 86/204 (42%), Gaps = 18/204 (8%)
Query: 240 PDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFN-R 298
P+ ++ASSS + I IW A+ G+ + + + +S D + L + +
Sbjct: 55 PNGEWLASSSADKLIKIWGAYDGKFEKTISGHK-----LGISDVAWSSDSNLLVSASDDK 109
Query: 299 TVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGS 358
T++++ D +G S + C F+P L GS+ S+ ++ G
Sbjct: 110 TLKIW-------DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162
Query: 359 PLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIY 418
L L H ++ + F+ DG+ S + D WD SG L +L + N +
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSS-YDGLCRIWD-TASGQCLKTLIDD--DNPPVS 218
Query: 419 F-DLDPTGQFLVSGSTSGAVSVWD 441
F P G+++++ + + +WD
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWD 242
Score = 47.0 bits (110), Expect = 5e-05
Identities = 39/141 (27%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 304 STARPGRDCEVRATFAKK---QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
S+A + V+ +A K G + +S + FSP A S + + ++ DG
Sbjct: 21 SSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE 80
Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
+ GH+ GI+ + + D N S A D L WD+ SG L +L + +N +
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVS-ASDDKTLKIWDV-SSGKCLKTL--KGHSNYVFCCN 136
Query: 421 LDPTGQFLVSGSTSGAVSVWD 441
+P +VSGS +V +WD
Sbjct: 137 FNPQSNLIVSGSFDESVRIWD 157
Score = 46.6 bits (109), Expect = 6e-05
Identities = 63/310 (20%), Positives = 128/310 (41%), Gaps = 46/310 (14%)
Query: 176 KWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLM 235
K++P+G + ++SAD +++I+ ++G ++ + + ++ I D W S
Sbjct: 52 KFSPNGEWLASSSADKLIKIWGA-----YDG---KFEKTISGHKL----GISDVAWSS-- 97
Query: 236 SSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLC--FSPDGSQLF 293
D++ + S+S + + IWD +G+ + + +++ + C F+P + +
Sbjct: 98 -----DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN-------YVFCCNFNPQSNLIV 145
Query: 294 CG-FNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLY 352
G F+ +VR++ D + S +S + F+ L SY ++
Sbjct: 146 SGSFDESVRIW-------DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 353 AWDDGSPL-ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREV 411
G L L+ ++ + F P+G ++ A D L WD G L +
Sbjct: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNG-KYILAATLDNTLKLWDY-SKGKCLKTYTGHK 256
Query: 412 TTNQRIYFDLDPT-GQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLH 470
I+ + T G+++VSGS V +W N E V D + H
Sbjct: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIW------NLQTKEIVQKLQGHTDVVISTACH 310
Query: 471 PSLPLLATAS 480
P+ ++A+A+
Sbjct: 311 PTENIIASAA 320
Score = 44.3 bits (103), Expect = 3e-04
Identities = 49/248 (19%), Positives = 97/248 (39%), Gaps = 40/248 (16%)
Query: 161 WSEFSTQPENFLKGCK-------WAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAE 213
W + + E + G K W+ D + +++ S D L+I+++
Sbjct: 72 WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG------------ 119
Query: 214 MVPVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNH 273
L+ ++G + Y +C + P ++ + S S + + IWD TG+ + A H
Sbjct: 120 --KCLKTLKGHSNYVFC-----CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA--H 170
Query: 274 LDELTAAHSLCFSPDGSQLF-CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIA 332
D ++A H F+ DGS + ++ R++ TA + + +S +
Sbjct: 171 SDPVSAVH---FNRDGSLIVSSSYDGLCRIWDTA------SGQCLKTLIDDDNPPVSFVK 221
Query: 333 FSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGG--ITHLCFHPDGNRFFSGARKDA 390
FSP + +L L+ + G L GH+ F G ++ +D
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281
Query: 391 ELLCWDLR 398
+ W+L+
Sbjct: 282 LVYIWNLQ 289
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 50.1 bits (118), Expect = 5e-06
Identities = 45/204 (22%), Positives = 86/204 (42%), Gaps = 18/204 (8%)
Query: 240 PDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFN-R 298
P+ ++ASSS + I IW A+ G+ + + + +S D + L + +
Sbjct: 55 PNGEWLASSSADKLIKIWGAYDGKFEKTISGHK-----LGISDVAWSSDSNLLVSASDDK 109
Query: 299 TVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGS 358
T++++ D +G S + C F+P L GS+ S+ ++ G
Sbjct: 110 TLKIW-------DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162
Query: 359 PLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIY 418
L L H ++ + F+ DG+ S + D WD SG L +L + N +
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSS-YDGLCRIWD-TASGQCLKTLIDD--DNPPVS 218
Query: 419 F-DLDPTGQFLVSGSTSGAVSVWD 441
F P G+++++ + + +WD
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWD 242
Score = 47.0 bits (110), Expect = 5e-05
Identities = 39/141 (27%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 304 STARPGRDCEVRATFAKK---QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
S+A + V+ +A K G + +S + FSP A S + + ++ DG
Sbjct: 21 SSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE 80
Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
+ GH+ GI+ + + D N S A D L WD+ SG L +L + +N +
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVS-ASDDKTLKIWDV-SSGKCLKTL--KGHSNYVFCCN 136
Query: 421 LDPTGQFLVSGSTSGAVSVWD 441
+P +VSGS +V +WD
Sbjct: 137 FNPQSNLIVSGSFDESVRIWD 157
Score = 46.6 bits (109), Expect = 6e-05
Identities = 63/310 (20%), Positives = 128/310 (41%), Gaps = 46/310 (14%)
Query: 176 KWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLM 235
K++P+G + ++SAD +++I+ ++G ++ + + ++ I D W S
Sbjct: 52 KFSPNGEWLASSSADKLIKIWGA-----YDG---KFEKTISGHKL----GISDVAWSS-- 97
Query: 236 SSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLC--FSPDGSQLF 293
D++ + S+S + + IWD +G+ + + +++ + C F+P + +
Sbjct: 98 -----DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN-------YVFCCNFNPQSNLIV 145
Query: 294 CG-FNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLY 352
G F+ +VR++ D + S +S + F+ L SY ++
Sbjct: 146 SGSFDESVRIW-------DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 353 AWDDGSPL-ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREV 411
G L L+ ++ + F P+G ++ A D L WD G L +
Sbjct: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNG-KYILAATLDNTLKLWDY-SKGKCLKTYTGHK 256
Query: 412 TTNQRIYFDLDPT-GQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLH 470
I+ + T G+++VSGS V +W N E V D + H
Sbjct: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIW------NLQTKEIVQKLQGHTDVVISTACH 310
Query: 471 PSLPLLATAS 480
P+ ++A+A+
Sbjct: 311 PTENIIASAA 320
Score = 44.3 bits (103), Expect = 3e-04
Identities = 49/248 (19%), Positives = 97/248 (39%), Gaps = 40/248 (16%)
Query: 161 WSEFSTQPENFLKGCK-------WAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAE 213
W + + E + G K W+ D + +++ S D L+I+++
Sbjct: 72 WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG------------ 119
Query: 214 MVPVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNH 273
L+ ++G + Y +C + P ++ + S S + + IWD TG+ + A H
Sbjct: 120 --KCLKTLKGHSNYVFC-----CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA--H 170
Query: 274 LDELTAAHSLCFSPDGSQLF-CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIA 332
D ++A H F+ DGS + ++ R++ TA + + +S +
Sbjct: 171 SDPVSAVH---FNRDGSLIVSSSYDGLCRIWDTA------SGQCLKTLIDDDNPPVSFVK 221
Query: 333 FSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGG--ITHLCFHPDGNRFFSGARKDA 390
FSP + +L L+ + G L GH+ F G ++ +D
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281
Query: 391 ELLCWDLR 398
+ W+L+
Sbjct: 282 LVYIWNLQ 289
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 50.1 bits (118), Expect = 5e-06
Identities = 44/156 (28%), Positives = 66/156 (42%), Gaps = 14/156 (8%)
Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLF-CGFNRT 299
D S + + S + +WDA G+ A+ H DE+ + CF G + + T
Sbjct: 272 DCSLILTGSMDKTCKLWDATNGKCVATLTG--HDDEILDS---CFDYTGKLIATASADGT 326
Query: 300 VRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSP 359
R+FS A R AK +G G IS I+F+P GS ++ ++ G
Sbjct: 327 ARIFSAA-------TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQC 379
Query: 360 LALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCW 395
L +L GH I F+ GN +G+ KD W
Sbjct: 380 LQVLEGHTDEIFSCAFNYKGNIVITGS-KDNTCRIW 414
Score = 49.3 bits (116), Expect = 9e-06
Identities = 36/152 (23%), Positives = 71/152 (46%), Gaps = 15/152 (9%)
Query: 247 SSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFS-PDGSQLFCG-FNRTVRVFS 304
+ S + +WD +GE + + ++ +++ F+ P G ++ G F++T +++S
Sbjct: 109 TGSYDRTCKLWDTASGEELNTLEGHRNV-----VYAIAFNNPYGDKIATGSFDKTCKLWS 163
Query: 305 TARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLG 364
E + +G + I C++F+P L A GS + L+ +G + L
Sbjct: 164 V-------ETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
Query: 365 GHQGGITHLCFHPDGNRFFSGARKDAELLCWD 396
GH I L F+ G+R +G+ D ++ WD
Sbjct: 217 GHSAEIISLSFNTSGDRIITGS-FDHTVVVWD 247
Score = 45.8 bits (107), Expect = 1e-04
Identities = 38/153 (24%), Positives = 69/153 (45%), Gaps = 10/153 (6%)
Query: 297 NRTVRVFSTARPGRDCEVRATFAKKQ-----GQSGIISCIAFS-PAQPLYACGSYGRSLG 350
N++ F T R C++ T + ++ G ++ IAF+ P A GS+ ++
Sbjct: 101 NKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCK 160
Query: 351 LYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGRE 410
L++ + G GH I L F+P +G+ D WD+ Q+G +++L
Sbjct: 161 LWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM-DTTAKLWDI-QNGEEVYTLRGH 218
Query: 411 VTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDTD 443
+ + I + +G +++GS V VWD D
Sbjct: 219 --SAEIISLSFNTSGDRIITGSFDHTVVVWDAD 249
Score = 45.8 bits (107), Expect = 1e-04
Identities = 53/207 (25%), Positives = 83/207 (40%), Gaps = 19/207 (9%)
Query: 237 SAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCG- 295
S P ++ VA+ S + +WD GE + R H E+ SL F+ G ++ G
Sbjct: 184 SFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRG--HSAEII---SLSFNTSGDRIITGS 238
Query: 296 FNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWD 355
F+ TV V+ A GR + G IS +F+ L GS ++ L+
Sbjct: 239 FDHTVVVWD-ADTGRKVNILI------GHCAEISSASFNWDCSLILTGSMDKTCKLWDAT 291
Query: 356 DGSPLALLGGHQGGITHLCFHPDGNRFFSG-ARKDAELLCWDLRQSGYPLWSLGREVTTN 414
+G +A L GH I CF G + A A + R+ L E++
Sbjct: 292 NGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISK- 350
Query: 415 QRIYFDLDPTGQFLVSGSTSGAVSVWD 441
+P G L++GS+ +WD
Sbjct: 351 ----ISFNPQGNHLLTGSSDKTARIWD 373
Score = 39.7 bits (91), Expect = 0.007
Identities = 52/260 (20%), Positives = 99/260 (38%), Gaps = 33/260 (12%)
Query: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240
GSC +T S D ++++ GE+ L +EG Y ++ P
Sbjct: 104 GSCFITGSYDRTCKLWDTA-----SGEE---------LNTLEGHRNVVYA----IAFNNP 145
Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300
+A+ S + +W TG+ +FR H E+ L F+P + + G T
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRG--HTAEIVC---LSFNPQSTLVATGSMDTT 200
Query: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
+ G + +G S I ++F+ + GS+ ++ ++ D G +
Sbjct: 201 AKLWDIQNGEEVYTL------RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV 254
Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
+L GH I+ F+ D + +G+ D WD G + ++ +
Sbjct: 255 NILIGHCAEISSASFNWDCSLILTGS-MDKTCKLWDATNGKCVATLTGHD---DEILDSC 310
Query: 421 LDPTGQFLVSGSTSGAVSVW 440
D TG+ + + S G ++
Sbjct: 311 FDYTGKLIATASADGTARIF 330
Score = 30.4 bits (67), Expect = 4.4
Identities = 24/112 (21%), Positives = 45/112 (40%), Gaps = 5/112 (4%)
Query: 331 IAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCF-HPDGNRFFSGARKD 389
+A + + + GSY R+ L+ G L L GH+ + + F +P G++ +G+ D
Sbjct: 98 VALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS-FD 156
Query: 390 AELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
W + G T + + +P + +GS +WD
Sbjct: 157 KTCKLWSVETGKCYHTFRGH---TAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
>gi|189571685 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 49.7 bits (117), Expect = 7e-06
Identities = 40/149 (26%), Positives = 67/149 (44%), Gaps = 10/149 (6%)
Query: 294 CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYA 353
C ++T+R++S RD + + + + C FSP+ + A S + L+
Sbjct: 28 CSLDKTIRLYSL----RDF-TELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN 82
Query: 354 WDDGSPLALLGGHQGGITHLC-FHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVT 412
++G LA++ G +C F PD SGA D ++ W+ + Y L+ G V
Sbjct: 83 TENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAA-DGTVVLWNAQS--YKLYRCG-SVK 138
Query: 413 TNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
P G F V+GS+ G ++VWD
Sbjct: 139 DGSLAACAFSPNGSFFVTGSSCGDLTVWD 167
Score = 30.0 bits (66), Expect = 5.7
Identities = 45/219 (20%), Positives = 84/219 (38%), Gaps = 44/219 (20%)
Query: 175 CKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSL 234
C+++PD +C+ + +AD + ++N + V+ + C +S
Sbjct: 103 CQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAA-------------CAFS- 148
Query: 235 MSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFC 294
P+ S+ + S + +WD ++R H +T FS SQ
Sbjct: 149 -----PNGSFFVTGSSCGDLTVWD---DKMRCLHSEKAHDLGITCCD---FS---SQPVS 194
Query: 295 GFNRTVRVFSTARPGRDCEVRATFAK-----------KQGQSG----IISCIAFSPAQPL 339
+ ++ F A G+DC+V+ K SG +++C AFS +
Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLAC-AFSHDGQM 253
Query: 340 YACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPD 378
GS +S+ +Y + + L L H +T F P+
Sbjct: 254 LVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPN 292
>gi|189571683 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 49.7 bits (117), Expect = 7e-06
Identities = 40/149 (26%), Positives = 67/149 (44%), Gaps = 10/149 (6%)
Query: 294 CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYA 353
C ++T+R++S RD + + + + C FSP+ + A S + L+
Sbjct: 28 CSLDKTIRLYSL----RDF-TELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN 82
Query: 354 WDDGSPLALLGGHQGGITHLC-FHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVT 412
++G LA++ G +C F PD SGA D ++ W+ + Y L+ G V
Sbjct: 83 TENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAA-DGTVVLWNAQS--YKLYRCG-SVK 138
Query: 413 TNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
P G F V+GS+ G ++VWD
Sbjct: 139 DGSLAACAFSPNGSFFVTGSSCGDLTVWD 167
Score = 30.0 bits (66), Expect = 5.7
Identities = 45/219 (20%), Positives = 84/219 (38%), Gaps = 44/219 (20%)
Query: 175 CKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSL 234
C+++PD +C+ + +AD + ++N + V+ + C +S
Sbjct: 103 CQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAA-------------CAFS- 148
Query: 235 MSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFC 294
P+ S+ + S + +WD ++R H +T FS SQ
Sbjct: 149 -----PNGSFFVTGSSCGDLTVWD---DKMRCLHSEKAHDLGITCCD---FS---SQPVS 194
Query: 295 GFNRTVRVFSTARPGRDCEVRATFAK-----------KQGQSG----IISCIAFSPAQPL 339
+ ++ F A G+DC+V+ K SG +++C AFS +
Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLAC-AFSHDGQM 253
Query: 340 YACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPD 378
GS +S+ +Y + + L L H +T F P+
Sbjct: 254 LVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPN 292
>gi|189571681 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 49.7 bits (117), Expect = 7e-06
Identities = 40/149 (26%), Positives = 67/149 (44%), Gaps = 10/149 (6%)
Query: 294 CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYA 353
C ++T+R++S RD + + + + C FSP+ + A S + L+
Sbjct: 28 CSLDKTIRLYSL----RDF-TELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN 82
Query: 354 WDDGSPLALLGGHQGGITHLC-FHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVT 412
++G LA++ G +C F PD SGA D ++ W+ + Y L+ G V
Sbjct: 83 TENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAA-DGTVVLWNAQS--YKLYRCG-SVK 138
Query: 413 TNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
P G F V+GS+ G ++VWD
Sbjct: 139 DGSLAACAFSPNGSFFVTGSSCGDLTVWD 167
Score = 30.0 bits (66), Expect = 5.7
Identities = 45/219 (20%), Positives = 84/219 (38%), Gaps = 44/219 (20%)
Query: 175 CKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSL 234
C+++PD +C+ + +AD + ++N + V+ + C +S
Sbjct: 103 CQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAA-------------CAFS- 148
Query: 235 MSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFC 294
P+ S+ + S + +WD ++R H +T FS SQ
Sbjct: 149 -----PNGSFFVTGSSCGDLTVWD---DKMRCLHSEKAHDLGITCCD---FS---SQPVS 194
Query: 295 GFNRTVRVFSTARPGRDCEVRATFAK-----------KQGQSG----IISCIAFSPAQPL 339
+ ++ F A G+DC+V+ K SG +++C AFS +
Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLAC-AFSHDGQM 253
Query: 340 YACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPD 378
GS +S+ +Y + + L L H +T F P+
Sbjct: 254 LVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPN 292
>gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]
Length = 1243
Score = 48.5 bits (114), Expect = 2e-05
Identities = 53/187 (28%), Positives = 74/187 (39%), Gaps = 23/187 (12%)
Query: 5 ETQPLAPDCCPSDQDPAPAHPSPHASPMNKNA--DSELMPPP--PERGDPPRLSPDPVAG 60
++ P P PS P P P SP A +SE PPP P G+ RL+P G
Sbjct: 951 QSPPAPPSPLPSLPLPPPVAPGGQESPSPHTAEVESEASPPPARPLPGE-ARLAPISEEG 1009
Query: 61 S-------AVSQELREGDPVSLSTPLETEFGSPSELSPRI-EEQELSENTSLPAEEANGS 112
V+ +P+ L T GSP +P++ E +E+++ E +
Sbjct: 1010 KPQLVGRFQVTSSKEPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGGPETREA 1069
Query: 113 LSEEEANGPELGSGKAME-------DTSGEPAAEDEGDTAW-NYSFSQLPRFLSGSWSEF 164
L+E + LG+G E G P W NYS+S L LS SE
Sbjct: 1070 LAESDRAAEGLGAGVEEEGDDGKEPQVGGSPQPLSHPSPVWMNYSYSSL--CLSSEESES 1127
Query: 165 STQPENF 171
S + E F
Sbjct: 1128 SGEDEEF 1134
>gi|89886480 zinedin isoform 2 [Homo sapiens]
Length = 760
Score = 48.5 bits (114), Expect = 2e-05
Identities = 72/314 (22%), Positives = 119/314 (37%), Gaps = 37/314 (11%)
Query: 182 SCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQPD 241
S +LT S D L+++NL + + E + R G L + +
Sbjct: 458 SALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPV--------LAVAMGSN 509
Query: 242 TSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAH----------SLCFSPDGSQ 291
+ Y S + IH W S Y+ D +H L FSP +
Sbjct: 510 SEYCYSGGADACIHSWKIPD----LSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQR 565
Query: 292 LF-CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSY-GRSL 349
L C + TVR++ + C TF + G+ + +AF+ +P + S+
Sbjct: 566 LASCSADGTVRIWDPSSSSPAC--LCTFPTAS-EHGVPTSVAFTSTEPAHIVASFRSGDT 622
Query: 350 GLYAWDDGSPLALLGGHQGG----ITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLW 405
LY + GS L L I + HP+ + A D + D R +G P+
Sbjct: 623 VLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTIT-AHDDRGIRFLDNR-TGKPVH 680
Query: 406 SLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTN 465
S+ + + +DP G FL+SGS ++ +W D E ++ +
Sbjct: 681 SMVAHLDAVTCLA--VDPNGAFLMSGSHDCSLRLWSLD--NKTCVQEITAHRKKHEEAIH 736
Query: 466 GVSLHPSLPLLATA 479
V+ HPS L+A+A
Sbjct: 737 AVACHPSKALIASA 750
>gi|89886477 zinedin isoform 1 [Homo sapiens]
Length = 753
Score = 48.5 bits (114), Expect = 2e-05
Identities = 72/314 (22%), Positives = 119/314 (37%), Gaps = 37/314 (11%)
Query: 182 SCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQPD 241
S +LT S D L+++NL + + E + R G L + +
Sbjct: 451 SALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPV--------LAVAMGSN 502
Query: 242 TSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAH----------SLCFSPDGSQ 291
+ Y S + IH W S Y+ D +H L FSP +
Sbjct: 503 SEYCYSGGADACIHSWKIPD----LSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQR 558
Query: 292 LF-CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSY-GRSL 349
L C + TVR++ + C TF + G+ + +AF+ +P + S+
Sbjct: 559 LASCSADGTVRIWDPSSSSPAC--LCTFPTAS-EHGVPTSVAFTSTEPAHIVASFRSGDT 615
Query: 350 GLYAWDDGSPLALLGGHQGG----ITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLW 405
LY + GS L L I + HP+ + A D + D R +G P+
Sbjct: 616 VLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTIT-AHDDRGIRFLDNR-TGKPVH 673
Query: 406 SLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTN 465
S+ + + +DP G FL+SGS ++ +W D E ++ +
Sbjct: 674 SMVAHLDAVTCLA--VDPNGAFLMSGSHDCSLRLWSLD--NKTCVQEITAHRKKHEEAIH 729
Query: 466 GVSLHPSLPLLATA 479
V+ HPS L+A+A
Sbjct: 730 AVACHPSKALIASA 743
>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
[Homo sapiens]
Length = 2269
Score = 47.8 bits (112), Expect = 3e-05
Identities = 48/192 (25%), Positives = 81/192 (42%), Gaps = 17/192 (8%)
Query: 259 AFTGELRASFRAYNH-LDELTAAHSLCFSPDGSQLFCGFNRT-VRVFSTARPGRDCEVRA 316
AF G + + + L L+A + + F G ++F G + V+++ST GR
Sbjct: 167 AFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHN-GR------ 219
Query: 317 TFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFH 376
+ +G S IS +A + + A GS + + ++ +P+A+L GH G IT L F
Sbjct: 220 LLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFS 279
Query: 377 P---DGNRFFSGARKDAELLCW-----DLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFL 428
P R+ D + W L+ S PL + Q + G FL
Sbjct: 280 PMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFL 339
Query: 429 VSGSTSGAVSVW 440
+GST + ++
Sbjct: 340 ATGSTDHVIRMY 351
>gi|16445436 bromodomain and WD repeat domain containing 1 isoform A
[Homo sapiens]
Length = 2320
Score = 47.8 bits (112), Expect = 3e-05
Identities = 48/192 (25%), Positives = 81/192 (42%), Gaps = 17/192 (8%)
Query: 259 AFTGELRASFRAYNH-LDELTAAHSLCFSPDGSQLFCGFNRT-VRVFSTARPGRDCEVRA 316
AF G + + + L L+A + + F G ++F G + V+++ST GR
Sbjct: 167 AFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHN-GR------ 219
Query: 317 TFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFH 376
+ +G S IS +A + + A GS + + ++ +P+A+L GH G IT L F
Sbjct: 220 LLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFS 279
Query: 377 P---DGNRFFSGARKDAELLCW-----DLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFL 428
P R+ D + W L+ S PL + Q + G FL
Sbjct: 280 PMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFL 339
Query: 429 VSGSTSGAVSVW 440
+GST + ++
Sbjct: 340 ATGSTDHVIRMY 351
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 47.8 bits (112), Expect = 3e-05
Identities = 31/128 (24%), Positives = 54/128 (42%), Gaps = 4/128 (3%)
Query: 313 EVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITH 372
E + + G +I+ + FSP + A S+ +S+ L+ G LA L GH +
Sbjct: 68 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 127
Query: 373 LCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGS 432
+ + D SG+ D+ L WD++ + G ++ D P GQ + SG
Sbjct: 128 IAWSADSRLLVSGS-SDSTLKVWDVKAQKLAMDLPGH---ADEVYAVDWSPDGQRVASGG 183
Query: 433 TSGAVSVW 440
+ +W
Sbjct: 184 KDKCLRIW 191
Score = 47.0 bits (110), Expect = 5e-05
Identities = 33/94 (35%), Positives = 45/94 (47%), Gaps = 7/94 (7%)
Query: 351 LYAW---DDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSL 407
L+ W +D PL + GHQ I + F PD +R + A D + WD R Y L SL
Sbjct: 61 LFLWSPAEDKKPLTRMTGHQALINQVLFSPD-SRIVASASFDKSIKLWDGRTGKY-LASL 118
Query: 408 GREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
V +I + D + LVSGS+ + VWD
Sbjct: 119 RGHVAAVYQIAWSAD--SRLLVSGSSDSTLKVWD 150
Score = 35.8 bits (81), Expect = 0.10
Identities = 32/117 (27%), Positives = 50/117 (42%), Gaps = 19/117 (16%)
Query: 216 PVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLD 275
P+ RM + + +S PD+ VAS+S + I +WD TG+ AS R +
Sbjct: 72 PLTRMTGHQALINQVLFS------PDSRIVASASFDKSIKLWDGRTGKYLASLRGH---- 121
Query: 276 ELTAAHSLCFSPDGSQLFCG-FNRTVRVFSTAR-------PGRDCEVRATFAKKQGQ 324
+ A + + +S D L G + T++V+ PG EV A GQ
Sbjct: 122 -VAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ 177
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.134 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,482,377
Number of Sequences: 37866
Number of extensions: 1629579
Number of successful extensions: 8913
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 128
Number of HSP's successfully gapped in prelim test: 574
Number of HSP's that attempted gapping in prelim test: 6684
Number of HSP's gapped (non-prelim): 2300
length of query: 548
length of database: 18,247,518
effective HSP length: 107
effective length of query: 441
effective length of database: 14,195,856
effective search space: 6260372496
effective search space used: 6260372496
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.