Guide to the Human Genome
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Search of human proteins with 221136858

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|221136858 WD repeat domain 79 isoform 2 [Homo sapiens]
         (548 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|221136866 WD repeat domain 79 isoform 4 [Homo sapiens]            1149   0.0  
gi|221136862 WD repeat domain 79 isoform 3 [Homo sapiens]            1149   0.0  
gi|221136858 WD repeat domain 79 isoform 2 [Homo sapiens]            1149   0.0  
gi|221136854 WD repeat domain 79 isoform 1 [Homo sapiens]            1149   0.0  
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     74   4e-13
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     64   5e-10
gi|26665869 WD repeat domain 51B [Homo sapiens]                        57   6e-08
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     55   2e-07
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            55   2e-07
gi|23199987 WD repeat domain 5B [Homo sapiens]                         54   5e-07
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ...    53   8e-07
gi|113865883 WD repeat domain 38 [Homo sapiens]                        52   1e-06
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)...    52   1e-06
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [...    51   2e-06
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    51   3e-06
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             50   4e-06
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             50   4e-06
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [...    50   4e-06
gi|16554629 WD repeat domain 5 [Homo sapiens]                          50   5e-06
gi|16554627 WD repeat domain 5 [Homo sapiens]                          50   5e-06
gi|32189425 WD repeat domain 69 [Homo sapiens]                         50   5e-06
gi|189571685 WD repeat, sterile alpha motif and U-box domain con...    50   7e-06
gi|189571683 WD repeat, sterile alpha motif and U-box domain con...    50   7e-06
gi|189571681 WD repeat, sterile alpha motif and U-box domain con...    50   7e-06
gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]       49   2e-05
gi|89886480 zinedin isoform 2 [Homo sapiens]                           49   2e-05
gi|89886477 zinedin isoform 1 [Homo sapiens]                           49   2e-05
gi|16445438 bromodomain and WD repeat domain containing 1 isofor...    48   3e-05
gi|16445436 bromodomain and WD repeat domain containing 1 isofor...    48   3e-05
gi|62234438 Notchless gene homolog isoform b [Homo sapiens]            48   3e-05

>gi|221136866 WD repeat domain 79 isoform 4 [Homo sapiens]
          Length = 548

 Score = 1149 bits (2972), Expect = 0.0
 Identities = 548/548 (100%), Positives = 548/548 (100%)

Query: 1   MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60
           MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG
Sbjct: 1   MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60

Query: 61  SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120
           SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG
Sbjct: 61  SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120

Query: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180
           PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD
Sbjct: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180

Query: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240
           GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP
Sbjct: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240

Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300
           DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV
Sbjct: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300

Query: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
           RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL
Sbjct: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360

Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
           ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD
Sbjct: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420

Query: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
           LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS
Sbjct: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480

Query: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540
           GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT
Sbjct: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540

Query: 541 EGGVGELI 548
           EGGVGELI
Sbjct: 541 EGGVGELI 548


>gi|221136862 WD repeat domain 79 isoform 3 [Homo sapiens]
          Length = 548

 Score = 1149 bits (2972), Expect = 0.0
 Identities = 548/548 (100%), Positives = 548/548 (100%)

Query: 1   MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60
           MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG
Sbjct: 1   MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60

Query: 61  SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120
           SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG
Sbjct: 61  SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120

Query: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180
           PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD
Sbjct: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180

Query: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240
           GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP
Sbjct: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240

Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300
           DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV
Sbjct: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300

Query: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
           RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL
Sbjct: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360

Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
           ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD
Sbjct: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420

Query: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
           LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS
Sbjct: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480

Query: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540
           GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT
Sbjct: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540

Query: 541 EGGVGELI 548
           EGGVGELI
Sbjct: 541 EGGVGELI 548


>gi|221136858 WD repeat domain 79 isoform 2 [Homo sapiens]
          Length = 548

 Score = 1149 bits (2972), Expect = 0.0
 Identities = 548/548 (100%), Positives = 548/548 (100%)

Query: 1   MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60
           MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG
Sbjct: 1   MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60

Query: 61  SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120
           SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG
Sbjct: 61  SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120

Query: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180
           PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD
Sbjct: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180

Query: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240
           GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP
Sbjct: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240

Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300
           DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV
Sbjct: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300

Query: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
           RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL
Sbjct: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360

Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
           ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD
Sbjct: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420

Query: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
           LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS
Sbjct: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480

Query: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540
           GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT
Sbjct: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540

Query: 541 EGGVGELI 548
           EGGVGELI
Sbjct: 541 EGGVGELI 548


>gi|221136854 WD repeat domain 79 isoform 1 [Homo sapiens]
          Length = 548

 Score = 1149 bits (2972), Expect = 0.0
 Identities = 548/548 (100%), Positives = 548/548 (100%)

Query: 1   MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60
           MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG
Sbjct: 1   MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG 60

Query: 61  SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120
           SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG
Sbjct: 61  SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG 120

Query: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180
           PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD
Sbjct: 121 PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD 180

Query: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240
           GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP
Sbjct: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240

Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300
           DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV
Sbjct: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300

Query: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
           RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL
Sbjct: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360

Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
           ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD
Sbjct: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420

Query: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
           LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS
Sbjct: 421 LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480

Query: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540
           GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT
Sbjct: 481 GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT 540

Query: 541 EGGVGELI 548
           EGGVGELI
Sbjct: 541 EGGVGELI 548


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 68/275 (24%), Positives = 117/275 (42%), Gaps = 29/275 (10%)

Query: 180 DGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVP------VLRMVEGDT------IY 227
           D S I    AD+ +R++++ P+     +Q     ++       + R+++  T      +Y
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILY 540

Query: 228 DYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSP 287
            +      +S  PD +Y+ SSS +  + +W   T      ++ +N+           FSP
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNY-----PVWDTQFSP 595

Query: 288 DGSQLFCG-FNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYG 346
            G     G  +R  R+++T       +    FA   G    ++C  F P     A GS  
Sbjct: 596 YGYYFVSGGHDRVARLWATDH----YQPLRIFA---GHLADVNCTRFHPNSNYVATGSAD 648

Query: 347 RSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWS 406
           R++ L+   +G+ + +  GH+G I  L F P+G RF +    D  +L WD+   G  +  
Sbjct: 649 RTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNG-RFLATGATDGRVLLWDIGH-GLMVGE 706

Query: 407 LGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
           L     T   + F  D  G+ L SGS    V +WD
Sbjct: 707 LKGHTDTVCSLRFSRD--GEILASGSMDNTVRLWD 739



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 34/135 (25%), Positives = 47/135 (34%), Gaps = 28/135 (20%)

Query: 358 SPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQ---------SGYPLWSLG 408
           S L +L GH G +    F PD N   S + +D  +  W L+            YP+W   
Sbjct: 534 SELKILYGHSGPVYGASFSPDRNYLLSSS-EDGTVRLWSLQTFTCLVGYKGHNYPVWDT- 591

Query: 409 REVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVS 468
                         P G + VSG       +W TD        +P+  F       N   
Sbjct: 592 -----------QFSPYGYYFVSGGHDRVARLWATD------HYQPLRIFAGHLADVNCTR 634

Query: 469 LHPSLPLLATASGQR 483
            HP+   +AT S  R
Sbjct: 635 FHPNSNYVATGSADR 649


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 68/292 (23%), Positives = 122/292 (41%), Gaps = 40/292 (13%)

Query: 169 ENFLKGCKWAPDGSCILTNSADNILRIYNL-PPELYHEGEQVEYAEMVPVLRMVEGDTIY 227
           E  L   + +PD   +     ++ +++++L   +L  E  QV+ + +     ++E +   
Sbjct: 268 EQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDE 327

Query: 228 D------------YCWYSLMSSAQPDTSYVASSSRENPIHIWD--AFTGELRASFRAYNH 273
           D            +C     +    D+S + S S +  I  WD  +FT  +     AY  
Sbjct: 328 DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV 387

Query: 274 LDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTARPGRDCEVRATFAKK--QGQSGIISCI 331
            D   + +SL F+  GS      +RT R++S  R         T+  +   G    + C+
Sbjct: 388 WDLDISPYSLYFA-SGSH-----DRTARLWSFDR---------TYPLRIYAGHLADVDCV 432

Query: 332 AFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAE 391
            F P     A GS  +++ L++   G+ + L  GH+G +  L F P+G ++ + A +D  
Sbjct: 433 KFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG-KYLASAGEDQR 491

Query: 392 LLCWDLRQSGYPLWSLGREVT--TNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
           L  WDL        +L +E+   T+        P    + S S   +V VWD
Sbjct: 492 LKLWDLASG-----TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 59/266 (22%), Positives = 108/266 (40%), Gaps = 36/266 (13%)

Query: 159 GSWSEFSTQPENFLKGCKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVL 218
           G +SEF       ++   ++ DG  + T S D  ++++++  + +               
Sbjct: 93  GKFSEFKAHTAP-VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLY------------- 138

Query: 219 RMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELT 278
                 ++Y +  +   +   PD   + S S +  I IWD    +   +F      D + 
Sbjct: 139 ------SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS-----DSVG 187

Query: 279 AAHSLCFSPDGSQLF-CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQ 337
            A+ + F+P G+ +   G ++TV+V+       D  V       Q  SG ++CI+F P+ 
Sbjct: 188 FANFVDFNPSGTCIASAGSDQTVKVW-------DVRVNKLLQHYQVHSGGVNCISFHPSG 240

Query: 338 PLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDL 397
                 S   +L +    +G  +  L GH G +  + F   G  F SG   D ++L W  
Sbjct: 241 NYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGG-ADTQVLLW-- 297

Query: 398 RQSGYPLWSLGREVTTNQRIYFDLDP 423
           R +   L   G      +R++FD  P
Sbjct: 298 RTNFDELHCKGLTKRNLKRLHFDSPP 323



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 58/255 (22%), Positives = 98/255 (38%), Gaps = 49/255 (19%)

Query: 240 PDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGF-NR 298
           P+   +A++S +  + +W+      +   RAY ++       S+ FSP G+ L     +R
Sbjct: 28  PNGKQLATASWDTFLMLWN-----FKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDR 82

Query: 299 TVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGS 358
           TVR++   + G+  E +A  A        +  + FS      A  S  +S+ +++     
Sbjct: 83  TVRLWIPDKRGKFSEFKAHTAP-------VRSVDFSADGQFLATASEDKSIKVWSMYRQR 135

Query: 359 PLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRI- 417
            L  L  H   +    F PDG R      +D  +  WD               TTN++  
Sbjct: 136 FLYSLYRHTHWVRCAKFSPDG-RLIVSCSEDKTIKIWD---------------TTNKQCV 179

Query: 418 -----------YFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLS-FLPQKDCTN 465
                      + D +P+G  + S  +   V VWD        +   +L  +       N
Sbjct: 180 NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV-------RVNKLLQHYQVHSGGVN 232

Query: 466 GVSLHPSLPLLATAS 480
            +S HPS   L TAS
Sbjct: 233 CISFHPSGNYLITAS 247



 Score = 32.7 bits (73), Expect = 0.88
 Identities = 30/119 (25%), Positives = 49/119 (41%), Gaps = 4/119 (3%)

Query: 322 QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNR 381
           +G    I+ +  SP     A  S+   L L+ +   +      GH+  +T + F P GN 
Sbjct: 15  KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN- 73

Query: 382 FFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVW 440
             + A +D  +  W   + G   +S  +  T   R   D    GQFL + S   ++ VW
Sbjct: 74  LLASASRDRTVRLWIPDKRG--KFSEFKAHTAPVR-SVDFSADGQFLATASEDKSIKVW 129


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 49/192 (25%), Positives = 73/192 (38%), Gaps = 31/192 (16%)

Query: 306 ARPGRDCEVRATFAKKQ-------GQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGS 358
           A  G DC V      K        G +  +  +  +  + L   GS   S+ ++  +   
Sbjct: 37  ATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAK 96

Query: 359 PLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIY 418
            L  L GH+  I  L FHP G  F +   +D  +  WD+R+ G      G          
Sbjct: 97  ILRTLMGHKANICSLDFHPYGE-FVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR---C 152

Query: 419 FDLDPTGQFLVSGSTSGAVSVWD-------TDGPGNDGKPEPVLSFLPQKDCTNGVSLHP 471
               P G++L S +    V +WD       ++ PG+ G   PV          N V  HP
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG---PV----------NVVEFHP 199

Query: 472 SLPLLATASGQR 483
           +  LLA+ S  R
Sbjct: 200 NEYLLASGSSDR 211



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 50/206 (24%), Positives = 85/206 (41%), Gaps = 23/206 (11%)

Query: 197 NLPPELYHEGEQ-----VEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRE 251
           N P EL   G Q     V   E   +LR + G    + C         P   +VAS S++
Sbjct: 72  NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA-NICSLDF----HPYGEFVASGSQD 126

Query: 252 NPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFN-RTVRVFSTARPGR 310
             I +WD     +R     + +     A   L FSPDG  L    +  TV+++       
Sbjct: 127 TNIKLWD-----IRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLW------- 174

Query: 311 DCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGI 370
           D       ++  G +G ++ + F P + L A GS  R++  +  +    ++ + G  G +
Sbjct: 175 DLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPV 234

Query: 371 THLCFHPDGNRFFSGARKDAELLCWD 396
             + F+PDG   +SG +    +  W+
Sbjct: 235 RSVLFNPDGCCLYSGCQDSLRVYGWE 260


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 87/357 (24%), Positives = 132/357 (36%), Gaps = 87/357 (24%)

Query: 133 SGEPAAEDEGDTA---WNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPDGSCILTNSA 189
           +G+  A   GDT    W+ S ++ P F             +++    W+PDG  + +   
Sbjct: 125 TGKYLASGSGDTTVRFWDLS-TETPHFTCKGH-------RHWVLSISWSPDGRKLASGCK 176

Query: 190 DNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDT--IYDYCWYSLMSSAQPDTSYVAS 247
           +  + +++        G+QV         R + G +  I    W  L   A P+  YVAS
Sbjct: 177 NGQILLWDPST-----GKQVG--------RTLAGHSKWITGLSWEPL--HANPECRYVAS 221

Query: 248 SSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTAR 307
           SS++  + IWD   G  R       H   +T    L +  DG       +RT++V+  A 
Sbjct: 222 SSKDGSVRIWDTTAG--RCERILTGHTQSVTC---LRWGGDGLLYSASQDRTIKVW-RAH 275

Query: 308 PGRDCEVRATFAKKQGQSGIISCI-----------AFSPAQPLY---------------A 341
            G  C         QG    ++ +           AF PA+                  A
Sbjct: 276 DGVLCRT------LQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERA 329

Query: 342 CGSYGRSLG--------------LYAW---DDGSPLALLGGHQGGITHLCFHPDGNRFFS 384
              Y    G              L+ W   +D  PL  + GHQ  I  + F PD +R  +
Sbjct: 330 LSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD-SRIVA 388

Query: 385 GARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
            A  D  +  WD R   Y L SL   V    +I +  D   + LVSGS+   + VWD
Sbjct: 389 SASFDKSIKLWDGRTGKY-LASLRGHVAAVYQIAWSAD--SRLLVSGSSDSTLKVWD 442



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 33/124 (26%), Positives = 57/124 (45%), Gaps = 4/124 (3%)

Query: 322 QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNR 381
           +G S  +  +AFSP     A GS   ++  +     +P     GH+  +  + + PDG +
Sbjct: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK 170

Query: 382 FFSGARKDAELLCWDL---RQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVS 438
             SG  K+ ++L WD    +Q G  L    + +T         +P  +++ S S  G+V 
Sbjct: 171 LASGC-KNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229

Query: 439 VWDT 442
           +WDT
Sbjct: 230 IWDT 233



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 31/128 (24%), Positives = 54/128 (42%), Gaps = 4/128 (3%)

Query: 313 EVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITH 372
           E +    +  G   +I+ + FSP   + A  S+ +S+ L+    G  LA L GH   +  
Sbjct: 360 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419

Query: 373 LCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGS 432
           + +  D     SG+  D+ L  WD++     +   G     ++    D  P GQ + SG 
Sbjct: 420 IAWSADSRLLVSGS-SDSTLKVWDVKAQKLAMDLPGH---ADEVYAVDWSPDGQRVASGG 475

Query: 433 TSGAVSVW 440
               + +W
Sbjct: 476 KDKCLRIW 483



 Score = 35.8 bits (81), Expect = 0.10
 Identities = 32/117 (27%), Positives = 50/117 (42%), Gaps = 19/117 (16%)

Query: 216 PVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLD 275
           P+ RM     + +   +S      PD+  VAS+S +  I +WD  TG+  AS R +    
Sbjct: 364 PLTRMTGHQALINQVLFS------PDSRIVASASFDKSIKLWDGRTGKYLASLRGH---- 413

Query: 276 ELTAAHSLCFSPDGSQLFCG-FNRTVRVFSTAR-------PGRDCEVRATFAKKQGQ 324
            + A + + +S D   L  G  + T++V+           PG   EV A      GQ
Sbjct: 414 -VAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ 469



 Score = 35.0 bits (79), Expect = 0.18
 Identities = 39/162 (24%), Positives = 63/162 (38%), Gaps = 19/162 (11%)

Query: 240 PDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGF-NR 298
           P   Y+AS S +  +  WD  T     + + + H        S+ +SPDG +L  G  N 
Sbjct: 124 PTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHW-----VLSISWSPDGRKLASGCKNG 178

Query: 299 TVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYAC---GSYGRSLGLYAWD 355
            + ++    P    +V  T A   G S  I+ +++ P      C    S  +   +  WD
Sbjct: 179 QILLWD---PSTGKQVGRTLA---GHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232

Query: 356 D--GSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCW 395
              G    +L GH   +T  C    G+     A +D  +  W
Sbjct: 233 TTAGRCERILTGHTQSVT--CLRWGGDGLLYSASQDRTIKVW 272


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 48/203 (23%), Positives = 88/203 (43%), Gaps = 16/203 (7%)

Query: 240 PDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRT 299
           P+  ++ASSS +  I IW A+ G+   +   Y H  E++    + +S D S+L    +  
Sbjct: 51  PNGEWLASSSADRLIIIWGAYDGKYEKTL--YGHNLEIS---DVAWSSDSSRLVSASDDK 105

Query: 300 VRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSP 359
                  R G+  +        +G S  + C  F+P   L   GS+  ++ ++    G  
Sbjct: 106 TLKLWDVRSGKCLKTL------KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159

Query: 360 LALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYF 419
           L  L  H   ++ + F+  G+   SG+  D     WD   SG  L +L  +   N  + F
Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGS-YDGLCRIWD-AASGQCLKTLVDD--DNPPVSF 215

Query: 420 -DLDPTGQFLVSGSTSGAVSVWD 441
               P G+++++ +    + +WD
Sbjct: 216 VKFSPNGKYILTATLDNTLKLWD 238



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 66/310 (21%), Positives = 126/310 (40%), Gaps = 46/310 (14%)

Query: 176 KWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLM 235
           K++P+G  + ++SAD ++ I+      Y   E+  Y   +          I D  W S  
Sbjct: 48  KFSPNGEWLASSSADRLIIIWGAYDGKY---EKTLYGHNL---------EISDVAWSS-- 93

Query: 236 SSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLC--FSPDGSQLF 293
                D+S + S+S +  + +WD  +G+   + + +++       +  C  F+P  + + 
Sbjct: 94  -----DSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSN-------YVFCCNFNPPSNLII 141

Query: 294 CG-FNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLY 352
            G F+ TV+++       + +           S  +S + F+ +  L   GSY     ++
Sbjct: 142 SGSFDETVKIW-------EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194

Query: 353 AWDDGSPL-ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREV 411
               G  L  L+      ++ + F P+G ++   A  D  L  WD  + G  L +     
Sbjct: 195 DAASGQCLKTLVDDDNPPVSFVKFSPNG-KYILTATLDNTLKLWDYSR-GRCLKTYTGHK 252

Query: 412 TTNQRIYFDLDPT-GQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLH 470
                I+ +   T G+++VSGS    V +W      N    E V       D     + H
Sbjct: 253 NEKYCIFANFSVTGGKWIVSGSEDNLVYIW------NLQTKEIVQKLQGHTDVVISAACH 306

Query: 471 PSLPLLATAS 480
           P+  L+A+A+
Sbjct: 307 PTENLIASAA 316



 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 38/141 (26%), Positives = 62/141 (43%), Gaps = 7/141 (4%)

Query: 304 STARPGRDCEVRATFAKK---QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
           S+A   ++      +A K    G +  +S + FSP     A  S  R + ++   DG   
Sbjct: 17  SSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE 76

Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
             L GH   I+ + +  D +R  S A  D  L  WD+R SG  L +L  +  +N     +
Sbjct: 77  KTLYGHNLEISDVAWSSDSSRLVS-ASDDKTLKLWDVR-SGKCLKTL--KGHSNYVFCCN 132

Query: 421 LDPTGQFLVSGSTSGAVSVWD 441
            +P    ++SGS    V +W+
Sbjct: 133 FNPPSNLIISGSFDETVKIWE 153


>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
           sapiens]
          Length = 421

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 43/158 (27%), Positives = 67/158 (42%), Gaps = 14/158 (8%)

Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNR-- 298
           D   +A+      I IWD +TG+L       N +D       L F+PDGS +    +R  
Sbjct: 139 DQLLLATGLNNGRIKIWDVYTGKL-----LLNLVDHTEVVRDLTFAPDGSLILVSASRDK 193

Query: 299 TVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGS 358
           T+RV+     G   +V      +  Q+ + SC AFSP   +       +++ L+  D  +
Sbjct: 194 TLRVWDLKDDGNMMKVL-----RGHQNWVYSC-AFSPDSSMLCSVGASKAVFLWNMDKYT 247

Query: 359 PLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWD 396
            +  L GH   +    F PDG    + A  D  +  WD
Sbjct: 248 MIRKLEGHHHDVVACDFSPDG-ALLATASYDTRVYIWD 284



 Score = 37.0 bits (84), Expect = 0.047
 Identities = 30/113 (26%), Positives = 45/113 (39%), Gaps = 6/113 (5%)

Query: 333 FSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAEL 392
           F   Q L A G     + ++    G  L  L  H   +  L F PDG+     A +D  L
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195

Query: 393 LCWDLRQSGYPLWSLGREVTTNQRIYFD--LDPTGQFLVSGSTSGAVSVWDTD 443
             WDL+  G    ++ + +  +Q   +     P    L S   S AV +W+ D
Sbjct: 196 RVWDLKDDG----NMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMD 244



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 22/103 (21%), Positives = 48/103 (46%), Gaps = 25/103 (24%)

Query: 169 ENFLKGCKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEG---DT 225
           +N++  C ++PD S + +  A   + ++N+              +   ++R +EG   D 
Sbjct: 214 QNWVYSCAFSPDSSMLCSVGASKAVFLWNM--------------DKYTMIRKLEGHHHDV 259

Query: 226 IYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASF 268
           +   C +S      PD + +A++S +  ++IWD   G++   F
Sbjct: 260 VA--CDFS------PDGALLATASYDTRVYIWDPHNGDILMEF 294


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 47/161 (29%), Positives = 66/161 (40%), Gaps = 10/161 (6%)

Query: 281 HSLCFSPDGSQLFCGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLY 340
           +S  FSPDG  L  G           R G+         +  G +G +    FSP   L+
Sbjct: 25  NSSAFSPDGQMLLTGSEDGCVYGWETRSGQ------LLWRLGGHTGPVKFCRFSPDGHLF 78

Query: 341 ACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQS 400
           A  S   ++ L+       L +L GHQ  +  + F PD  +  SG   D  ++ WD+ QS
Sbjct: 79  ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGG-WDKRVMLWDV-QS 136

Query: 401 GYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
           G  L  L     + Q    D  PT   L +GS    V +WD
Sbjct: 137 GQMLRLLVGHRDSIQS--SDFSPTVNCLATGSWDSTVHIWD 175



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 78/339 (23%), Positives = 135/339 (39%), Gaps = 53/339 (15%)

Query: 101 NTSLPAEEANGSLSEEEANGPELGSGKAMEDTSGEPAAEDEGDT-AWNYSFSQLPRFLSG 159
           N+ +PA  A   +     +G E+ S     D        ++G    W     QL   L G
Sbjct: 2   NSGVPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGG 61

Query: 160 SWSEFSTQPENFLKGCKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLR 219
                 T P  F   C+++PDG    + S D  +R++++                   LR
Sbjct: 62  H-----TGPVKF---CRFSPDGHLFASASCDCTVRLWDV--------------ARAKCLR 99

Query: 220 MVEG-----DTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHL 274
           +++G     +T+          S  PD+  +AS   +  + +WD  +G++        H 
Sbjct: 100 VLKGHQRSVETV----------SFSPDSRQLASGGWDKRVMLWDVQSGQMLRLL--VGHR 147

Query: 275 DELTAAHSLCFSPDGSQLFCG-FNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAF 333
           D + ++    FSP  + L  G ++ TV ++      R      +    +G S  ISC+ +
Sbjct: 148 DSIQSSD---FSPTVNCLATGSWDSTVHIWDL----RMVTPAVSHQALEGHSANISCLCY 200

Query: 334 SPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELL 393
           S A  L A GS+ +++ ++     S L  L GH   +  + F PD   + + A     + 
Sbjct: 201 S-ASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD-ELWLASAGYSRMVK 258

Query: 394 CWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGS 432
            WD   +G  L +L   +       F   P G+ LVSG+
Sbjct: 259 VWDC-NTGKCLETLKGVLDVAHTCAF--TPDGKILVSGA 294



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 39/157 (24%), Positives = 61/157 (38%), Gaps = 14/157 (8%)

Query: 326 GIISCIAFSPAQPLYACGSYGRSLGLYAWD--DGSPLALLGGHQGGITHLCFHPDGNRFF 383
           G ++  AFSP   +   GS    +  Y W+   G  L  LGGH G +    F PDG+  F
Sbjct: 22  GEVNSSAFSPDGQMLLTGSEDGCV--YGWETRSGQLLWRLGGHTGPVKFCRFSPDGH-LF 78

Query: 384 SGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDTD 443
           + A  D  +  WD+ ++       G + +          P  + L SG     V +WD  
Sbjct: 79  ASASCDCTVRLWDVARAKCLRVLKGHQRSVET---VSFSPDSRQLASGGWDKRVMLWDVQ 135

Query: 444 GPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
                   + +   +  +D        P++  LAT S
Sbjct: 136 ------SGQMLRLLVGHRDSIQSSDFSPTVNCLATGS 166


>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
           [Homo sapiens]
          Length = 906

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 42/160 (26%), Positives = 60/160 (37%), Gaps = 8/160 (5%)

Query: 322 QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWD-DGSPLALLGGHQGGITHLCFHPDGN 380
           +  S  I CIA  P QP     S    + L+ WD   S   +  GH   +  +  +P  N
Sbjct: 96  EAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDN 155

Query: 381 RFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVW 440
             F+ A  D  +  W L  S       G E   N   Y+       +L+SG+    V +W
Sbjct: 156 NQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYS-GGDKPYLISGADDRLVKIW 214

Query: 441 DTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS 480
           D     N    + +        C    S HP LP++ T S
Sbjct: 215 DYQ---NKTCVQTLEGHAQNVSC---ASFHPELPIIITGS 248


>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
           [Homo sapiens]
          Length = 340

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 60/288 (20%), Positives = 100/288 (34%), Gaps = 78/288 (27%)

Query: 161 WSEFSTQP-------ENFLKGCKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAE 213
           W  ++T          +++  C +AP G+ +     DNI  IYNL      EG       
Sbjct: 82  WDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT---REGN------ 132

Query: 214 MVPVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNH 273
            V V R + G T Y  C   L      D + + +SS +    +WD  TG+   +F  +  
Sbjct: 133 -VRVSRELAGHTGYLSCCRFL------DDNQIVTSSGDTTCALWDIETGQQTTTFTGH-- 183

Query: 274 LDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAF 333
                                                              +G +  ++ 
Sbjct: 184 ---------------------------------------------------TGDVMSLSL 192

Query: 334 SPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELL 393
           +P   L+  G+   S  L+   +G       GH+  I  +CF P+GN F +G+  DA   
Sbjct: 193 APDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGS-DDATCR 251

Query: 394 CWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
            +DLR +   L +   +             +G+ L++G      +VWD
Sbjct: 252 LFDLR-ADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 75/334 (22%), Positives = 117/334 (35%), Gaps = 80/334 (23%)

Query: 137 AAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENF------LKGCK-------WAPDG-S 182
           A+ED     W+Y      R L G     S Q  +F      L  C        W   G  
Sbjct: 126 ASEDATIKVWDYETGDFERTLKGHTD--SVQDISFDHSGKLLASCSADMTIKLWDFQGFE 183

Query: 183 CILTNSAD--NILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYC---------W 231
           CI T      N+  +  +P      G+ +  A     ++M E  T   YC         W
Sbjct: 184 CIRTMHGHDHNVSSVAIMP-----NGDHIVSASRDKTIKMWEVQT--GYCVKTFTGHREW 236

Query: 232 YSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQ 291
             ++   Q D + +AS S +  + +W   T E +A  R + H+ E      + ++P+ S 
Sbjct: 237 VRMVRPNQ-DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE-----CISWAPESS- 289

Query: 292 LFCGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGL 351
                      +S+       E   +  KK G+ G           P    GS  +++ +
Sbjct: 290 -----------YSSI-----SEATGSETKKSGKPG-----------PFLLSGSRDKTIKM 322

Query: 352 YAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREV 411
           +    G  L  L GH   +  + FH  G +F      D  L  WD +             
Sbjct: 323 WDVSTGMCLMTLVGHDNWVRGVLFH-SGGKFILSCADDKTLRVWDYKNKRC-------MK 374

Query: 412 TTNQRIYF----DLDPTGQFLVSGSTSGAVSVWD 441
           T N   +F    D   T  ++V+GS    V VW+
Sbjct: 375 TLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408



 Score = 36.2 bits (82), Expect = 0.080
 Identities = 25/82 (30%), Positives = 38/82 (46%), Gaps = 4/82 (4%)

Query: 363 LGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLD 422
           L GH+  +T + FHP  +   S A +DA +  WD     +   +L     + Q I F  D
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVS-ASEDATIKVWDYETGDFER-TLKGHTDSVQDISF--D 159

Query: 423 PTGQFLVSGSTSGAVSVWDTDG 444
            +G+ L S S    + +WD  G
Sbjct: 160 HSGKLLASCSADMTIKLWDFQG 181


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 59/244 (24%), Positives = 92/244 (37%), Gaps = 29/244 (11%)

Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGF-NRT 299
           +T  +AS S ++ + +W      ++   RAY       A   + FSP G  L  G  ++T
Sbjct: 30  NTKQLASGSMDSCLMVW-----HMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKT 84

Query: 300 VRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSP 359
           VR++     G     RA        +  +  + F      +   S  +++ ++A      
Sbjct: 85  VRIWVPNVKGESTVFRA-------HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137

Query: 360 LALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDL--RQSGYPLWSLGREVTTNQRI 417
           L  L  H   +    F PDG R    A  D  +  WD   R+  +     G  VT     
Sbjct: 138 LFSLSQHINWVRCAKFSPDG-RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT----- 191

Query: 418 YFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLS-FLPQKDCTNGVSLHPSLPLL 476
           Y D  P+G  + +      V VWD        +   +L  +       NG+S HPS   L
Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDV-------RTHRLLQHYQLHSAAVNGLSFHPSGNYL 244

Query: 477 ATAS 480
            TAS
Sbjct: 245 ITAS 248



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 37/157 (23%), Positives = 62/157 (39%), Gaps = 14/157 (8%)

Query: 240 PDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFC-GFNR 298
           PD   + S+S +  + +WD  + E   S+  +         H     P G+ +   G + 
Sbjct: 155 PDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH-----PSGTCIAAAGMDN 209

Query: 299 TVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGS 358
           TV+V+       D          Q  S  ++ ++F P+       S   +L +    +G 
Sbjct: 210 TVKVW-------DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGR 262

Query: 359 PLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCW 395
            L  L GHQG  T + F   G  F SG   D +++ W
Sbjct: 263 LLYTLHGHQGPATTVAFSRTGEYFASGG-SDEQVMVW 298



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 56/268 (20%), Positives = 107/268 (39%), Gaps = 36/268 (13%)

Query: 177 WAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMS 236
           ++P G  + + S D  +RI+   P +  +GE   +      +R V       +C      
Sbjct: 69  FSPSGHLLASGSRDKTVRIW--VPNV--KGESTVFRAHTATVRSVH------FC------ 112

Query: 237 SAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGF 296
               D     ++S +  + +W   T   +  F    H++ +  A    FSPDG  +    
Sbjct: 113 ---SDGQSFVTASDDKTVKVWA--THRQKFLFSLSQHINWVRCAK---FSPDGRLIVSAS 164

Query: 297 N-RTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWD 355
           + +TV+++   +  R+C    ++ +     G ++ + F P+    A      ++ ++   
Sbjct: 165 DDKTVKLWD--KSSRECV--HSYCE---HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217

Query: 356 DGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQ 415
               L     H   +  L FHP GN   + A  D+ L   DL + G  L++L        
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLIT-ASSDSTLKILDLME-GRLLYTLHGHQGPAT 275

Query: 416 RIYFDLDPTGQFLVSGSTSGAVSVWDTD 443
            + F    TG++  SG +   V VW ++
Sbjct: 276 TVAFSR--TGEYFASGGSDEQVMVWKSN 301



 Score = 36.6 bits (83), Expect = 0.061
 Identities = 32/121 (26%), Positives = 48/121 (39%), Gaps = 4/121 (3%)

Query: 322 QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNR 381
           +G    ++C+ FS      A GS    L ++     S      GH+  +T + F P G+ 
Sbjct: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75

Query: 382 FFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
             SG+R D  +  W     G           T + ++F  D  GQ  V+ S    V VW 
Sbjct: 76  LASGSR-DKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSD--GQSFVTASDDKTVKVWA 131

Query: 442 T 442
           T
Sbjct: 132 T 132


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 59/244 (24%), Positives = 92/244 (37%), Gaps = 29/244 (11%)

Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGF-NRT 299
           +T  +AS S ++ + +W      ++   RAY       A   + FSP G  L  G  ++T
Sbjct: 30  NTKQLASGSMDSCLMVW-----HMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKT 84

Query: 300 VRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSP 359
           VR++     G     RA        +  +  + F      +   S  +++ ++A      
Sbjct: 85  VRIWVPNVKGESTVFRA-------HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137

Query: 360 LALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDL--RQSGYPLWSLGREVTTNQRI 417
           L  L  H   +    F PDG R    A  D  +  WD   R+  +     G  VT     
Sbjct: 138 LFSLSQHINWVRCAKFSPDG-RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT----- 191

Query: 418 YFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLS-FLPQKDCTNGVSLHPSLPLL 476
           Y D  P+G  + +      V VWD        +   +L  +       NG+S HPS   L
Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDV-------RTHRLLQHYQLHSAAVNGLSFHPSGNYL 244

Query: 477 ATAS 480
            TAS
Sbjct: 245 ITAS 248



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 37/157 (23%), Positives = 62/157 (39%), Gaps = 14/157 (8%)

Query: 240 PDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFC-GFNR 298
           PD   + S+S +  + +WD  + E   S+  +         H     P G+ +   G + 
Sbjct: 155 PDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH-----PSGTCIAAAGMDN 209

Query: 299 TVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGS 358
           TV+V+       D          Q  S  ++ ++F P+       S   +L +    +G 
Sbjct: 210 TVKVW-------DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGR 262

Query: 359 PLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCW 395
            L  L GHQG  T + F   G  F SG   D +++ W
Sbjct: 263 LLYTLHGHQGPATTVAFSRTGEYFASGG-SDEQVMVW 298



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 56/268 (20%), Positives = 107/268 (39%), Gaps = 36/268 (13%)

Query: 177 WAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMS 236
           ++P G  + + S D  +RI+   P +  +GE   +      +R V       +C      
Sbjct: 69  FSPSGHLLASGSRDKTVRIW--VPNV--KGESTVFRAHTATVRSVH------FC------ 112

Query: 237 SAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGF 296
               D     ++S +  + +W   T   +  F    H++ +  A    FSPDG  +    
Sbjct: 113 ---SDGQSFVTASDDKTVKVWA--THRQKFLFSLSQHINWVRCAK---FSPDGRLIVSAS 164

Query: 297 N-RTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWD 355
           + +TV+++   +  R+C    ++ +     G ++ + F P+    A      ++ ++   
Sbjct: 165 DDKTVKLWD--KSSRECV--HSYCE---HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217

Query: 356 DGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQ 415
               L     H   +  L FHP GN   + A  D+ L   DL + G  L++L        
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLIT-ASSDSTLKILDLME-GRLLYTLHGHQGPAT 275

Query: 416 RIYFDLDPTGQFLVSGSTSGAVSVWDTD 443
            + F    TG++  SG +   V VW ++
Sbjct: 276 TVAFSR--TGEYFASGGSDEQVMVWKSN 301



 Score = 36.6 bits (83), Expect = 0.061
 Identities = 32/121 (26%), Positives = 48/121 (39%), Gaps = 4/121 (3%)

Query: 322 QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNR 381
           +G    ++C+ FS      A GS    L ++     S      GH+  +T + F P G+ 
Sbjct: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75

Query: 382 FFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
             SG+R D  +  W     G           T + ++F  D  GQ  V+ S    V VW 
Sbjct: 76  LASGSR-DKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSD--GQSFVTASDDKTVKVWA 131

Query: 442 T 442
           T
Sbjct: 132 T 132


>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
           [Homo sapiens]
          Length = 340

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 67/292 (22%), Positives = 109/292 (37%), Gaps = 44/292 (15%)

Query: 161 WSEFSTQP-------ENFLKGCKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAE 213
           W  ++T          +++  C +AP G+ +     DNI  IY+L      EG       
Sbjct: 82  WDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKT---REGN------ 132

Query: 214 MVPVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNH 273
            V V R + G T Y  C   L      D + + +SS +    +WD  TG+    F  ++ 
Sbjct: 133 -VRVSRELPGHTGYLSCCRFL------DDNQIITSSGDTTCALWDIETGQQTVGFAGHS- 184

Query: 274 LDELTAAHSLCFSPDGSQLFCG-FNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIA 332
                   SL  +PDG     G  + +++++      RD   R TF    G    I+ +A
Sbjct: 185 ----GDVMSLSLAPDGRTFVSGACDASIKLWDV----RDSMCRQTFI---GHESDINAVA 233

Query: 333 FSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQG---GITHLCFHPDGNRFFSGARKD 389
           F P    +  GS   +  L+       L L+  H     GIT + F   G    +G   D
Sbjct: 234 FFPNGYAFTTGSDDATCRLFDLRADQEL-LMYSHDNIICGITSVAFSRSGRLLLAG-YDD 291

Query: 390 AELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
                WD  +        G +   N+     +   G  + +GS    + +W+
Sbjct: 292 FNCNIWDAMKGDRAGVLAGHD---NRVSCLGVTDDGMAVATGSWDSFLKIWN 340


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 45/204 (22%), Positives = 86/204 (42%), Gaps = 18/204 (8%)

Query: 240 PDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFN-R 298
           P+  ++ASSS +  I IW A+ G+   +   +           + +S D + L    + +
Sbjct: 55  PNGEWLASSSADKLIKIWGAYDGKFEKTISGHK-----LGISDVAWSSDSNLLVSASDDK 109

Query: 299 TVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGS 358
           T++++       D          +G S  + C  F+P   L   GS+  S+ ++    G 
Sbjct: 110 TLKIW-------DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162

Query: 359 PLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIY 418
            L  L  H   ++ + F+ DG+   S +  D     WD   SG  L +L  +   N  + 
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSS-YDGLCRIWD-TASGQCLKTLIDD--DNPPVS 218

Query: 419 F-DLDPTGQFLVSGSTSGAVSVWD 441
           F    P G+++++ +    + +WD
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWD 242



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 39/141 (27%), Positives = 64/141 (45%), Gaps = 7/141 (4%)

Query: 304 STARPGRDCEVRATFAKK---QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
           S+A   +   V+  +A K    G +  +S + FSP     A  S  + + ++   DG   
Sbjct: 21  SSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE 80

Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
             + GH+ GI+ + +  D N   S A  D  L  WD+  SG  L +L  +  +N     +
Sbjct: 81  KTISGHKLGISDVAWSSDSNLLVS-ASDDKTLKIWDV-SSGKCLKTL--KGHSNYVFCCN 136

Query: 421 LDPTGQFLVSGSTSGAVSVWD 441
            +P    +VSGS   +V +WD
Sbjct: 137 FNPQSNLIVSGSFDESVRIWD 157



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 63/310 (20%), Positives = 128/310 (41%), Gaps = 46/310 (14%)

Query: 176 KWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLM 235
           K++P+G  + ++SAD +++I+       ++G   ++ + +   ++     I D  W S  
Sbjct: 52  KFSPNGEWLASSSADKLIKIWGA-----YDG---KFEKTISGHKL----GISDVAWSS-- 97

Query: 236 SSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLC--FSPDGSQLF 293
                D++ + S+S +  + IWD  +G+   + + +++       +  C  F+P  + + 
Sbjct: 98  -----DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN-------YVFCCNFNPQSNLIV 145

Query: 294 CG-FNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLY 352
            G F+ +VR++       D +           S  +S + F+    L    SY     ++
Sbjct: 146 SGSFDESVRIW-------DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198

Query: 353 AWDDGSPL-ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREV 411
               G  L  L+      ++ + F P+G ++   A  D  L  WD    G  L +     
Sbjct: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNG-KYILAATLDNTLKLWDY-SKGKCLKTYTGHK 256

Query: 412 TTNQRIYFDLDPT-GQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLH 470
                I+ +   T G+++VSGS    V +W      N    E V       D     + H
Sbjct: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIW------NLQTKEIVQKLQGHTDVVISTACH 310

Query: 471 PSLPLLATAS 480
           P+  ++A+A+
Sbjct: 311 PTENIIASAA 320



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 49/248 (19%), Positives = 97/248 (39%), Gaps = 40/248 (16%)

Query: 161 WSEFSTQPENFLKGCK-------WAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAE 213
           W  +  + E  + G K       W+ D + +++ S D  L+I+++               
Sbjct: 72  WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG------------ 119

Query: 214 MVPVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNH 273
               L+ ++G + Y +C      +  P ++ + S S +  + IWD  TG+   +  A  H
Sbjct: 120 --KCLKTLKGHSNYVFC-----CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA--H 170

Query: 274 LDELTAAHSLCFSPDGSQLF-CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIA 332
            D ++A H   F+ DGS +    ++   R++ TA        +         +  +S + 
Sbjct: 171 SDPVSAVH---FNRDGSLIVSSSYDGLCRIWDTA------SGQCLKTLIDDDNPPVSFVK 221

Query: 333 FSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGG--ITHLCFHPDGNRFFSGARKDA 390
           FSP        +   +L L+ +  G  L    GH+         F   G ++     +D 
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281

Query: 391 ELLCWDLR 398
            +  W+L+
Sbjct: 282 LVYIWNLQ 289


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 45/204 (22%), Positives = 86/204 (42%), Gaps = 18/204 (8%)

Query: 240 PDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFN-R 298
           P+  ++ASSS +  I IW A+ G+   +   +           + +S D + L    + +
Sbjct: 55  PNGEWLASSSADKLIKIWGAYDGKFEKTISGHK-----LGISDVAWSSDSNLLVSASDDK 109

Query: 299 TVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGS 358
           T++++       D          +G S  + C  F+P   L   GS+  S+ ++    G 
Sbjct: 110 TLKIW-------DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162

Query: 359 PLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIY 418
            L  L  H   ++ + F+ DG+   S +  D     WD   SG  L +L  +   N  + 
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSS-YDGLCRIWD-TASGQCLKTLIDD--DNPPVS 218

Query: 419 F-DLDPTGQFLVSGSTSGAVSVWD 441
           F    P G+++++ +    + +WD
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWD 242



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 39/141 (27%), Positives = 64/141 (45%), Gaps = 7/141 (4%)

Query: 304 STARPGRDCEVRATFAKK---QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
           S+A   +   V+  +A K    G +  +S + FSP     A  S  + + ++   DG   
Sbjct: 21  SSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE 80

Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
             + GH+ GI+ + +  D N   S A  D  L  WD+  SG  L +L  +  +N     +
Sbjct: 81  KTISGHKLGISDVAWSSDSNLLVS-ASDDKTLKIWDV-SSGKCLKTL--KGHSNYVFCCN 136

Query: 421 LDPTGQFLVSGSTSGAVSVWD 441
            +P    +VSGS   +V +WD
Sbjct: 137 FNPQSNLIVSGSFDESVRIWD 157



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 63/310 (20%), Positives = 128/310 (41%), Gaps = 46/310 (14%)

Query: 176 KWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLM 235
           K++P+G  + ++SAD +++I+       ++G   ++ + +   ++     I D  W S  
Sbjct: 52  KFSPNGEWLASSSADKLIKIWGA-----YDG---KFEKTISGHKL----GISDVAWSS-- 97

Query: 236 SSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLC--FSPDGSQLF 293
                D++ + S+S +  + IWD  +G+   + + +++       +  C  F+P  + + 
Sbjct: 98  -----DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN-------YVFCCNFNPQSNLIV 145

Query: 294 CG-FNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLY 352
            G F+ +VR++       D +           S  +S + F+    L    SY     ++
Sbjct: 146 SGSFDESVRIW-------DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198

Query: 353 AWDDGSPL-ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREV 411
               G  L  L+      ++ + F P+G ++   A  D  L  WD    G  L +     
Sbjct: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNG-KYILAATLDNTLKLWDY-SKGKCLKTYTGHK 256

Query: 412 TTNQRIYFDLDPT-GQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLH 470
                I+ +   T G+++VSGS    V +W      N    E V       D     + H
Sbjct: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIW------NLQTKEIVQKLQGHTDVVISTACH 310

Query: 471 PSLPLLATAS 480
           P+  ++A+A+
Sbjct: 311 PTENIIASAA 320



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 49/248 (19%), Positives = 97/248 (39%), Gaps = 40/248 (16%)

Query: 161 WSEFSTQPENFLKGCK-------WAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAE 213
           W  +  + E  + G K       W+ D + +++ S D  L+I+++               
Sbjct: 72  WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG------------ 119

Query: 214 MVPVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNH 273
               L+ ++G + Y +C      +  P ++ + S S +  + IWD  TG+   +  A  H
Sbjct: 120 --KCLKTLKGHSNYVFC-----CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA--H 170

Query: 274 LDELTAAHSLCFSPDGSQLF-CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIA 332
            D ++A H   F+ DGS +    ++   R++ TA        +         +  +S + 
Sbjct: 171 SDPVSAVH---FNRDGSLIVSSSYDGLCRIWDTA------SGQCLKTLIDDDNPPVSFVK 221

Query: 333 FSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGG--ITHLCFHPDGNRFFSGARKDA 390
           FSP        +   +L L+ +  G  L    GH+         F   G ++     +D 
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281

Query: 391 ELLCWDLR 398
            +  W+L+
Sbjct: 282 LVYIWNLQ 289


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 44/156 (28%), Positives = 66/156 (42%), Gaps = 14/156 (8%)

Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLF-CGFNRT 299
           D S + + S +    +WDA  G+  A+     H DE+  +   CF   G  +     + T
Sbjct: 272 DCSLILTGSMDKTCKLWDATNGKCVATLTG--HDDEILDS---CFDYTGKLIATASADGT 326

Query: 300 VRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSP 359
            R+FS A        R   AK +G  G IS I+F+P       GS  ++  ++    G  
Sbjct: 327 ARIFSAA-------TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQC 379

Query: 360 LALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCW 395
           L +L GH   I    F+  GN   +G+ KD     W
Sbjct: 380 LQVLEGHTDEIFSCAFNYKGNIVITGS-KDNTCRIW 414



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 36/152 (23%), Positives = 71/152 (46%), Gaps = 15/152 (9%)

Query: 247 SSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFS-PDGSQLFCG-FNRTVRVFS 304
           + S +    +WD  +GE   +   + ++      +++ F+ P G ++  G F++T +++S
Sbjct: 109 TGSYDRTCKLWDTASGEELNTLEGHRNV-----VYAIAFNNPYGDKIATGSFDKTCKLWS 163

Query: 305 TARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLG 364
                   E    +   +G +  I C++F+P   L A GS   +  L+   +G  +  L 
Sbjct: 164 V-------ETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216

Query: 365 GHQGGITHLCFHPDGNRFFSGARKDAELLCWD 396
           GH   I  L F+  G+R  +G+  D  ++ WD
Sbjct: 217 GHSAEIISLSFNTSGDRIITGS-FDHTVVVWD 247



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 38/153 (24%), Positives = 69/153 (45%), Gaps = 10/153 (6%)

Query: 297 NRTVRVFSTARPGRDCEVRATFAKKQ-----GQSGIISCIAFS-PAQPLYACGSYGRSLG 350
           N++   F T    R C++  T + ++     G   ++  IAF+ P     A GS+ ++  
Sbjct: 101 NKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCK 160

Query: 351 LYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGRE 410
           L++ + G       GH   I  L F+P      +G+  D     WD+ Q+G  +++L   
Sbjct: 161 LWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM-DTTAKLWDI-QNGEEVYTLRGH 218

Query: 411 VTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDTD 443
             + + I    + +G  +++GS    V VWD D
Sbjct: 219 --SAEIISLSFNTSGDRIITGSFDHTVVVWDAD 249



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 53/207 (25%), Positives = 83/207 (40%), Gaps = 19/207 (9%)

Query: 237 SAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCG- 295
           S  P ++ VA+ S +    +WD   GE   + R   H  E+    SL F+  G ++  G 
Sbjct: 184 SFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRG--HSAEII---SLSFNTSGDRIITGS 238

Query: 296 FNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWD 355
           F+ TV V+  A  GR   +        G    IS  +F+    L   GS  ++  L+   
Sbjct: 239 FDHTVVVWD-ADTGRKVNILI------GHCAEISSASFNWDCSLILTGSMDKTCKLWDAT 291

Query: 356 DGSPLALLGGHQGGITHLCFHPDGNRFFSG-ARKDAELLCWDLRQSGYPLWSLGREVTTN 414
           +G  +A L GH   I   CF   G    +  A   A +     R+    L     E++  
Sbjct: 292 NGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISK- 350

Query: 415 QRIYFDLDPTGQFLVSGSTSGAVSVWD 441
                  +P G  L++GS+     +WD
Sbjct: 351 ----ISFNPQGNHLLTGSSDKTARIWD 373



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 52/260 (20%), Positives = 99/260 (38%), Gaps = 33/260 (12%)

Query: 181 GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP 240
           GSC +T S D   ++++        GE+         L  +EG     Y     ++   P
Sbjct: 104 GSCFITGSYDRTCKLWDTA-----SGEE---------LNTLEGHRNVVYA----IAFNNP 145

Query: 241 DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV 300
               +A+ S +    +W   TG+   +FR   H  E+     L F+P  + +  G   T 
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRG--HTAEIVC---LSFNPQSTLVATGSMDTT 200

Query: 301 RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL 360
                 + G +          +G S  I  ++F+ +      GS+  ++ ++  D G  +
Sbjct: 201 AKLWDIQNGEEVYTL------RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV 254

Query: 361 ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD 420
            +L GH   I+   F+ D +   +G+  D     WD           G +   ++ +   
Sbjct: 255 NILIGHCAEISSASFNWDCSLILTGS-MDKTCKLWDATNGKCVATLTGHD---DEILDSC 310

Query: 421 LDPTGQFLVSGSTSGAVSVW 440
            D TG+ + + S  G   ++
Sbjct: 311 FDYTGKLIATASADGTARIF 330



 Score = 30.4 bits (67), Expect = 4.4
 Identities = 24/112 (21%), Positives = 45/112 (40%), Gaps = 5/112 (4%)

Query: 331 IAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCF-HPDGNRFFSGARKD 389
           +A + +   +  GSY R+  L+    G  L  L GH+  +  + F +P G++  +G+  D
Sbjct: 98  VALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS-FD 156

Query: 390 AELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
                W +          G    T + +    +P    + +GS      +WD
Sbjct: 157 KTCKLWSVETGKCYHTFRGH---TAEIVCLSFNPQSTLVATGSMDTTAKLWD 205


>gi|189571685 WD repeat, sterile alpha motif and U-box domain
           containing 1 [Homo sapiens]
          Length = 476

 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 40/149 (26%), Positives = 67/149 (44%), Gaps = 10/149 (6%)

Query: 294 CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYA 353
           C  ++T+R++S     RD       +  +  +  + C  FSP+  + A  S   +  L+ 
Sbjct: 28  CSLDKTIRLYSL----RDF-TELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN 82

Query: 354 WDDGSPLALLGGHQGGITHLC-FHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVT 412
            ++G  LA++    G    +C F PD     SGA  D  ++ W+ +   Y L+  G  V 
Sbjct: 83  TENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAA-DGTVVLWNAQS--YKLYRCG-SVK 138

Query: 413 TNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
                     P G F V+GS+ G ++VWD
Sbjct: 139 DGSLAACAFSPNGSFFVTGSSCGDLTVWD 167



 Score = 30.0 bits (66), Expect = 5.7
 Identities = 45/219 (20%), Positives = 84/219 (38%), Gaps = 44/219 (20%)

Query: 175 CKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSL 234
           C+++PD +C+ + +AD  + ++N      +    V+   +               C +S 
Sbjct: 103 CQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAA-------------CAFS- 148

Query: 235 MSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFC 294
                P+ S+  + S    + +WD    ++R       H   +T      FS   SQ   
Sbjct: 149 -----PNGSFFVTGSSCGDLTVWD---DKMRCLHSEKAHDLGITCCD---FS---SQPVS 194

Query: 295 GFNRTVRVFSTARPGRDCEVRATFAK-----------KQGQSG----IISCIAFSPAQPL 339
              + ++ F  A  G+DC+V+                K   SG    +++C AFS    +
Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLAC-AFSHDGQM 253

Query: 340 YACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPD 378
              GS  +S+ +Y  +  + L  L  H   +T   F P+
Sbjct: 254 LVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPN 292


>gi|189571683 WD repeat, sterile alpha motif and U-box domain
           containing 1 [Homo sapiens]
          Length = 476

 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 40/149 (26%), Positives = 67/149 (44%), Gaps = 10/149 (6%)

Query: 294 CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYA 353
           C  ++T+R++S     RD       +  +  +  + C  FSP+  + A  S   +  L+ 
Sbjct: 28  CSLDKTIRLYSL----RDF-TELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN 82

Query: 354 WDDGSPLALLGGHQGGITHLC-FHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVT 412
            ++G  LA++    G    +C F PD     SGA  D  ++ W+ +   Y L+  G  V 
Sbjct: 83  TENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAA-DGTVVLWNAQS--YKLYRCG-SVK 138

Query: 413 TNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
                     P G F V+GS+ G ++VWD
Sbjct: 139 DGSLAACAFSPNGSFFVTGSSCGDLTVWD 167



 Score = 30.0 bits (66), Expect = 5.7
 Identities = 45/219 (20%), Positives = 84/219 (38%), Gaps = 44/219 (20%)

Query: 175 CKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSL 234
           C+++PD +C+ + +AD  + ++N      +    V+   +               C +S 
Sbjct: 103 CQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAA-------------CAFS- 148

Query: 235 MSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFC 294
                P+ S+  + S    + +WD    ++R       H   +T      FS   SQ   
Sbjct: 149 -----PNGSFFVTGSSCGDLTVWD---DKMRCLHSEKAHDLGITCCD---FS---SQPVS 194

Query: 295 GFNRTVRVFSTARPGRDCEVRATFAK-----------KQGQSG----IISCIAFSPAQPL 339
              + ++ F  A  G+DC+V+                K   SG    +++C AFS    +
Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLAC-AFSHDGQM 253

Query: 340 YACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPD 378
              GS  +S+ +Y  +  + L  L  H   +T   F P+
Sbjct: 254 LVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPN 292


>gi|189571681 WD repeat, sterile alpha motif and U-box domain
           containing 1 [Homo sapiens]
          Length = 476

 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 40/149 (26%), Positives = 67/149 (44%), Gaps = 10/149 (6%)

Query: 294 CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYA 353
           C  ++T+R++S     RD       +  +  +  + C  FSP+  + A  S   +  L+ 
Sbjct: 28  CSLDKTIRLYSL----RDF-TELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN 82

Query: 354 WDDGSPLALLGGHQGGITHLC-FHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVT 412
            ++G  LA++    G    +C F PD     SGA  D  ++ W+ +   Y L+  G  V 
Sbjct: 83  TENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAA-DGTVVLWNAQS--YKLYRCG-SVK 138

Query: 413 TNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
                     P G F V+GS+ G ++VWD
Sbjct: 139 DGSLAACAFSPNGSFFVTGSSCGDLTVWD 167



 Score = 30.0 bits (66), Expect = 5.7
 Identities = 45/219 (20%), Positives = 84/219 (38%), Gaps = 44/219 (20%)

Query: 175 CKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSL 234
           C+++PD +C+ + +AD  + ++N      +    V+   +               C +S 
Sbjct: 103 CQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAA-------------CAFS- 148

Query: 235 MSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFC 294
                P+ S+  + S    + +WD    ++R       H   +T      FS   SQ   
Sbjct: 149 -----PNGSFFVTGSSCGDLTVWD---DKMRCLHSEKAHDLGITCCD---FS---SQPVS 194

Query: 295 GFNRTVRVFSTARPGRDCEVRATFAK-----------KQGQSG----IISCIAFSPAQPL 339
              + ++ F  A  G+DC+V+                K   SG    +++C AFS    +
Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLAC-AFSHDGQM 253

Query: 340 YACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPD 378
              GS  +S+ +Y  +  + L  L  H   +T   F P+
Sbjct: 254 LVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPN 292


>gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]
          Length = 1243

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 53/187 (28%), Positives = 74/187 (39%), Gaps = 23/187 (12%)

Query: 5    ETQPLAPDCCPSDQDPAPAHPSPHASPMNKNA--DSELMPPP--PERGDPPRLSPDPVAG 60
            ++ P  P   PS   P P  P    SP    A  +SE  PPP  P  G+  RL+P    G
Sbjct: 951  QSPPAPPSPLPSLPLPPPVAPGGQESPSPHTAEVESEASPPPARPLPGE-ARLAPISEEG 1009

Query: 61   S-------AVSQELREGDPVSLSTPLETEFGSPSELSPRI-EEQELSENTSLPAEEANGS 112
                     V+      +P+ L     T  GSP   +P++  E   +E+++    E   +
Sbjct: 1010 KPQLVGRFQVTSSKEPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGGPETREA 1069

Query: 113  LSEEEANGPELGSGKAME-------DTSGEPAAEDEGDTAW-NYSFSQLPRFLSGSWSEF 164
            L+E +     LG+G   E          G P         W NYS+S L   LS   SE 
Sbjct: 1070 LAESDRAAEGLGAGVEEEGDDGKEPQVGGSPQPLSHPSPVWMNYSYSSL--CLSSEESES 1127

Query: 165  STQPENF 171
            S + E F
Sbjct: 1128 SGEDEEF 1134


>gi|89886480 zinedin isoform 2 [Homo sapiens]
          Length = 760

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 72/314 (22%), Positives = 119/314 (37%), Gaps = 37/314 (11%)

Query: 182 SCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQPD 241
           S +LT S D  L+++NL   +  +       E +   R   G          L  +   +
Sbjct: 458 SALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPV--------LAVAMGSN 509

Query: 242 TSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAH----------SLCFSPDGSQ 291
           + Y  S   +  IH W         S   Y+  D    +H           L FSP   +
Sbjct: 510 SEYCYSGGADACIHSWKIPD----LSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQR 565

Query: 292 LF-CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSY-GRSL 349
           L  C  + TVR++  +     C    TF     + G+ + +AF+  +P +   S+     
Sbjct: 566 LASCSADGTVRIWDPSSSSPAC--LCTFPTAS-EHGVPTSVAFTSTEPAHIVASFRSGDT 622

Query: 350 GLYAWDDGSPLALLGGHQGG----ITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLW 405
            LY  + GS L  L          I  +  HP+     + A  D  +   D R +G P+ 
Sbjct: 623 VLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTIT-AHDDRGIRFLDNR-TGKPVH 680

Query: 406 SLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTN 465
           S+   +     +   +DP G FL+SGS   ++ +W  D        E        ++  +
Sbjct: 681 SMVAHLDAVTCLA--VDPNGAFLMSGSHDCSLRLWSLD--NKTCVQEITAHRKKHEEAIH 736

Query: 466 GVSLHPSLPLLATA 479
            V+ HPS  L+A+A
Sbjct: 737 AVACHPSKALIASA 750


>gi|89886477 zinedin isoform 1 [Homo sapiens]
          Length = 753

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 72/314 (22%), Positives = 119/314 (37%), Gaps = 37/314 (11%)

Query: 182 SCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQPD 241
           S +LT S D  L+++NL   +  +       E +   R   G          L  +   +
Sbjct: 451 SALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPV--------LAVAMGSN 502

Query: 242 TSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAH----------SLCFSPDGSQ 291
           + Y  S   +  IH W         S   Y+  D    +H           L FSP   +
Sbjct: 503 SEYCYSGGADACIHSWKIPD----LSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQR 558

Query: 292 LF-CGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSY-GRSL 349
           L  C  + TVR++  +     C    TF     + G+ + +AF+  +P +   S+     
Sbjct: 559 LASCSADGTVRIWDPSSSSPAC--LCTFPTAS-EHGVPTSVAFTSTEPAHIVASFRSGDT 615

Query: 350 GLYAWDDGSPLALLGGHQGG----ITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLW 405
            LY  + GS L  L          I  +  HP+     + A  D  +   D R +G P+ 
Sbjct: 616 VLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTIT-AHDDRGIRFLDNR-TGKPVH 673

Query: 406 SLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTN 465
           S+   +     +   +DP G FL+SGS   ++ +W  D        E        ++  +
Sbjct: 674 SMVAHLDAVTCLA--VDPNGAFLMSGSHDCSLRLWSLD--NKTCVQEITAHRKKHEEAIH 729

Query: 466 GVSLHPSLPLLATA 479
            V+ HPS  L+A+A
Sbjct: 730 AVACHPSKALIASA 743


>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
           [Homo sapiens]
          Length = 2269

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 48/192 (25%), Positives = 81/192 (42%), Gaps = 17/192 (8%)

Query: 259 AFTGELRASFRAYNH-LDELTAAHSLCFSPDGSQLFCGFNRT-VRVFSTARPGRDCEVRA 316
           AF G +    + +   L  L+A + + F   G ++F G +   V+++ST   GR      
Sbjct: 167 AFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHN-GR------ 219

Query: 317 TFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFH 376
             +  +G S  IS +A +    + A GS  + + ++     +P+A+L GH G IT L F 
Sbjct: 220 LLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFS 279

Query: 377 P---DGNRFFSGARKDAELLCW-----DLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFL 428
           P      R+      D  +  W      L+ S  PL    +     Q +       G FL
Sbjct: 280 PMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFL 339

Query: 429 VSGSTSGAVSVW 440
            +GST   + ++
Sbjct: 340 ATGSTDHVIRMY 351


>gi|16445436 bromodomain and WD repeat domain containing 1 isoform A
           [Homo sapiens]
          Length = 2320

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 48/192 (25%), Positives = 81/192 (42%), Gaps = 17/192 (8%)

Query: 259 AFTGELRASFRAYNH-LDELTAAHSLCFSPDGSQLFCGFNRT-VRVFSTARPGRDCEVRA 316
           AF G +    + +   L  L+A + + F   G ++F G +   V+++ST   GR      
Sbjct: 167 AFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHN-GR------ 219

Query: 317 TFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFH 376
             +  +G S  IS +A +    + A GS  + + ++     +P+A+L GH G IT L F 
Sbjct: 220 LLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFS 279

Query: 377 P---DGNRFFSGARKDAELLCW-----DLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFL 428
           P      R+      D  +  W      L+ S  PL    +     Q +       G FL
Sbjct: 280 PMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFL 339

Query: 429 VSGSTSGAVSVW 440
            +GST   + ++
Sbjct: 340 ATGSTDHVIRMY 351


>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
          Length = 193

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 31/128 (24%), Positives = 54/128 (42%), Gaps = 4/128 (3%)

Query: 313 EVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITH 372
           E +    +  G   +I+ + FSP   + A  S+ +S+ L+    G  LA L GH   +  
Sbjct: 68  EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 127

Query: 373 LCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGS 432
           + +  D     SG+  D+ L  WD++     +   G     ++    D  P GQ + SG 
Sbjct: 128 IAWSADSRLLVSGS-SDSTLKVWDVKAQKLAMDLPGH---ADEVYAVDWSPDGQRVASGG 183

Query: 433 TSGAVSVW 440
               + +W
Sbjct: 184 KDKCLRIW 191



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 33/94 (35%), Positives = 45/94 (47%), Gaps = 7/94 (7%)

Query: 351 LYAW---DDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSL 407
           L+ W   +D  PL  + GHQ  I  + F PD +R  + A  D  +  WD R   Y L SL
Sbjct: 61  LFLWSPAEDKKPLTRMTGHQALINQVLFSPD-SRIVASASFDKSIKLWDGRTGKY-LASL 118

Query: 408 GREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWD 441
              V    +I +  D   + LVSGS+   + VWD
Sbjct: 119 RGHVAAVYQIAWSAD--SRLLVSGSSDSTLKVWD 150



 Score = 35.8 bits (81), Expect = 0.10
 Identities = 32/117 (27%), Positives = 50/117 (42%), Gaps = 19/117 (16%)

Query: 216 PVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLD 275
           P+ RM     + +   +S      PD+  VAS+S +  I +WD  TG+  AS R +    
Sbjct: 72  PLTRMTGHQALINQVLFS------PDSRIVASASFDKSIKLWDGRTGKYLASLRGH---- 121

Query: 276 ELTAAHSLCFSPDGSQLFCG-FNRTVRVFSTAR-------PGRDCEVRATFAKKQGQ 324
            + A + + +S D   L  G  + T++V+           PG   EV A      GQ
Sbjct: 122 -VAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ 177


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.134    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,482,377
Number of Sequences: 37866
Number of extensions: 1629579
Number of successful extensions: 8913
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 128
Number of HSP's successfully gapped in prelim test: 574
Number of HSP's that attempted gapping in prelim test: 6684
Number of HSP's gapped (non-prelim): 2300
length of query: 548
length of database: 18,247,518
effective HSP length: 107
effective length of query: 441
effective length of database: 14,195,856
effective search space: 6260372496
effective search space used: 6260372496
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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