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Search of human proteins with 115298659
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
(2419 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 4793 0.0
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 2690 0.0
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 2684 0.0
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 567 e-161
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 495 e-139
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 495 e-139
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 483 e-136
gi|67782321 spectrin beta isoform a [Homo sapiens] 471 e-132
gi|67782319 spectrin beta isoform b [Homo sapiens] 471 e-132
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 361 4e-99
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens] 219 3e-56
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens] 217 1e-55
gi|221316624 dystonin isoform 4 [Homo sapiens] 214 6e-55
gi|221316622 dystonin isoform 3 [Homo sapiens] 214 6e-55
gi|221316618 dystonin isoform 2 [Homo sapiens] 214 6e-55
gi|34577047 dystonin isoform 1 [Homo sapiens] 214 6e-55
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 214 6e-55
gi|12025678 actinin, alpha 4 [Homo sapiens] 214 8e-55
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens] 213 2e-54
gi|4501893 actinin, alpha 2 [Homo sapiens] 206 2e-52
gi|33188443 microfilament and actin filament cross-linker protei... 191 1e-47
gi|33188445 microfilament and actin filament cross-linker protei... 191 1e-47
gi|4557241 actinin, alpha 3 [Homo sapiens] 188 6e-47
gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [... 185 5e-46
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 150 1e-35
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof... 147 2e-34
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 146 3e-34
gi|5032281 dystrophin Dp427c isoform [Homo sapiens] 142 3e-33
gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens] 142 3e-33
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens] 142 3e-33
>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
Length = 2419
Score = 4793 bits (12433), Expect = 0.0
Identities = 2419/2419 (100%), Positives = 2419/2419 (100%)
Query: 1 MEQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKR 60
MEQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKR
Sbjct: 1 MEQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKR 60
Query: 61 DADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFT 120
DADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFT
Sbjct: 61 DADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFT 120
Query: 121 MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAI 180
MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAI
Sbjct: 121 MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAI 180
Query: 181 ATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQN 240
ATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQN
Sbjct: 181 ATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQN 240
Query: 241 EVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASE 300
EVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASE
Sbjct: 241 EVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASE 300
Query: 301 GLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALAT 360
GLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALAT
Sbjct: 301 GLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALAT 360
Query: 361 SRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEID 420
SRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEID
Sbjct: 361 SRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEID 420
Query: 421 SYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHL 480
SYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHL
Sbjct: 421 SYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHL 480
Query: 481 FYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTAT 540
FYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTAT
Sbjct: 481 FYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTAT 540
Query: 541 KLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINK 600
KLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINK
Sbjct: 541 KLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINK 600
Query: 601 KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTT 660
KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTT
Sbjct: 601 KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTT 660
Query: 661 RLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLA 720
RLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLA
Sbjct: 661 RLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLA 720
Query: 721 EVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKE 780
EVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKE
Sbjct: 721 EVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKE 780
Query: 781 PLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILE 840
PLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILE
Sbjct: 781 PLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILE 840
Query: 841 NIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQ 900
NIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQ
Sbjct: 841 NIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQ 900
Query: 901 FQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRN 960
FQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRN
Sbjct: 901 FQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRN 960
Query: 961 QANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAA 1020
QANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAA
Sbjct: 961 QANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAA 1020
Query: 1021 DHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQ 1080
DHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQ
Sbjct: 1021 DHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQ 1080
Query: 1081 RYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKV 1140
RYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKV
Sbjct: 1081 RYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKV 1140
Query: 1141 ADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIE 1200
ADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIE
Sbjct: 1141 ADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIE 1200
Query: 1201 KKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDL 1260
KKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDL
Sbjct: 1201 KKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDL 1260
Query: 1261 QRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAED 1320
QRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAED
Sbjct: 1261 QRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAED 1320
Query: 1321 LTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDL 1380
LTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDL
Sbjct: 1321 LTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDL 1380
Query: 1381 EKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLD 1440
EKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLD
Sbjct: 1381 EKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLD 1440
Query: 1441 KAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYA 1500
KAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYA
Sbjct: 1441 KAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYA 1500
Query: 1501 NLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVIN 1560
NLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVIN
Sbjct: 1501 NLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVIN 1560
Query: 1561 LGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFE 1620
LGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFE
Sbjct: 1561 LGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFE 1620
Query: 1621 FWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFN 1680
FWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFN
Sbjct: 1621 FWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFN 1680
Query: 1681 VDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQD 1740
VDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQD
Sbjct: 1681 VDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQD 1740
Query: 1741 YGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEH 1800
YGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEH
Sbjct: 1741 YGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEH 1800
Query: 1801 WEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMK 1860
WEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMK
Sbjct: 1801 WEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMK 1860
Query: 1861 HEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAW 1920
HEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAW
Sbjct: 1861 HEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAW 1920
Query: 1921 KLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSF 1980
KLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSF
Sbjct: 1921 KLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSF 1980
Query: 1981 QQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQK 2040
QQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQK
Sbjct: 1981 QQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQK 2040
Query: 2041 AEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFK 2100
AEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFK
Sbjct: 2041 AEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFK 2100
Query: 2101 CLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQ 2160
CLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQ
Sbjct: 2101 CLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQ 2160
Query: 2161 EFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLG 2220
EFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLG
Sbjct: 2161 EFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLG 2220
Query: 2221 DNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIY 2280
DNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIY
Sbjct: 2221 DNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIY 2280
Query: 2281 KHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYT 2340
KHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYT
Sbjct: 2281 KHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYT 2340
Query: 2341 AFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQYMDPRG 2400
AFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQYMDPRG
Sbjct: 2341 AFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQYMDPRG 2400
Query: 2401 RSHLSGYDYVGFTNSYFGN 2419
RSHLSGYDYVGFTNSYFGN
Sbjct: 2401 RSHLSGYDYVGFTNSYFGN 2419
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 2690 bits (6974), Expect = 0.0
Identities = 1371/2477 (55%), Positives = 1793/2477 (72%), Gaps = 72/2477 (2%)
Query: 10 VESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWI 69
++ SG KVLETAE+IQERRQ+VL RY FKE R QKLEDSY Q F+RDA++L KWI
Sbjct: 1 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI 60
Query: 70 MEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEET 129
EK+ I +D++Y+DPTN+QGK QKHQ+ EAEVQ S + +L++T + GH A E
Sbjct: 61 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
Query: 130 KAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGED 189
+ + EL W+LLLE EKG +LL+A K QY++EC D+++WI DKEAI TS ELG+D
Sbjct: 121 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD 180
Query: 190 WERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERL 249
E EVL KKFE+FQ ++ A E RV EVNQ+A + +E HP+ LI++KQ+EVNAAW+RL
Sbjct: 181 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL 240
Query: 250 RGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGL 309
+GLALQRQ L AA +QRF RDV E I WIKEKE ++ S+D+G+DL + + L H+GL
Sbjct: 241 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300
Query: 310 ERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQAT 369
ER+LA + DKVK LCA+A++L SHP A QIQ +E+L+++WE IR LA R+ +L +
Sbjct: 301 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
Query: 370 YWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSA 429
Y RF +DF +L+ W+ E A INADEL +DVAG E LLDRHQ+HK EID+++D F+SA
Sbjct: 361 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420
Query: 430 DETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVD 489
DE+GQ L+ A H ASDEVREK+ +L ALLELW+ R +QYEQC+D LFYRD+EQVD
Sbjct: 421 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
Query: 490 SWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYD 549
+WMS+QEAFL NEDLG+SL S EALL+KHEDFE++ +AQEEKI +D+ ATKLI ++HY
Sbjct: 481 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
Query: 550 SENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDED 609
E++ RD LL+RR+AL E+A RR L +S LQ+ + DSD+LK+W+N+K K A DE
Sbjct: 541 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600
Query: 610 YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLW 669
YKD NL+ +VQK Q FE EL+ N+++++ ++K GQ++I+ HYA D V R++EV SLW
Sbjct: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
Query: 670 EELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729
++LLEAT+ KG +L EANQQ QF N ED++ WL +VE + S+DYGK L VQN +KH
Sbjct: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
Query: 730 GLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKL 789
LLE+ VAA QD++D +T A F++ GH D+++I+ +QE+LV R+EALKEP+ RK+KL
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
Query: 790 LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849
D L LQ + RD EDEE WI+E EP A ST GKDLI + LL +H+ + IA HEPRI
Sbjct: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
Query: 850 QEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLH 909
+ +T++GN MVEEGHFAAEDV +++ LNQ E+L+A+A++R+ DLE ++Q QQY AD +
Sbjct: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 910 EAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQ 969
EAE+W+REKEPIV +T+YG DE++A ALLKKHEA + DL+++G S++ALR QA +C +QQ
Sbjct: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSC-RQQ 959
Query: 970 AAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAV 1029
AP + G++ V+ALYD+Q +SPREVTMKKGD+LTLL+S NKDWWKVE D QG VPA
Sbjct: 960 VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019
Query: 1030 YVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQ--------------------YRSLLD 1069
YV++L + + EE G+I RQEQI+NQ Y SLL+
Sbjct: 1020 YVKKLDPAQ-SASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLE 1078
Query: 1070 RAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKA----ENTGVELDDVWELQKKFDEFQK 1125
E+R+ L + +F+L EA ++ +WI EK+A E G +L+ V LQKKFD+FQK
Sbjct: 1079 LGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQK 1138
Query: 1126 DLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQ-------------------------- 1159
DL NE RL+DINKVA+DL EGL+ E ++Q
Sbjct: 1139 DLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLM 1198
Query: 1160 -----------ELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSA 1208
ELN RW SLQ+LA+E+ QLLGSAH V+ FHR+AD+TKE IE+K QAL+
Sbjct: 1199 VHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNT 1258
Query: 1209 ADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELN 1268
+ G DL SVQALQR+HEGFERDL LGDKV LGETAERL +SHP++ EDLQ + ELN
Sbjct: 1259 DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
Query: 1269 EAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILL 1328
+AW L R RK L ++ FLS RDL +WI+ I G+VSS ELA+D+TG E LL
Sbjct: 1319 QAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL 1378
Query: 1329 ERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRK 1388
ERHQEHR +++A A TFQA E F +L+ GH+ASPEI++KL + ER DLEKAW +R+
Sbjct: 1379 ERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRR 1438
Query: 1389 KILDQCLELQMFQGNCDQVESWMVARENSLRSDDK-SSLDSLEALMKKRDDLDKAITAQE 1447
+LDQCLELQ+F +C+Q E+WM ARE L ++DK SLDS+EAL+KK +D DKAI QE
Sbjct: 1439 MMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQE 1498
Query: 1448 GKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYR 1507
KI L+ FA+ LIA HYAK +I++R VLDRW+ LKAQ+I++R+KLG+ L+QF R
Sbjct: 1499 EKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSR 1558
Query: 1508 DLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIE 1567
D++E+E WISE L TA DESYKD TNIQ K+ KHQ F E+ ++++ GVI++GNSLIE
Sbjct: 1559 DVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIE 1618
Query: 1568 CSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAE 1627
AC G+E+A+K +L L + W L++++ +K +KL EA++QQ FNT I+DF+FWLSE E
Sbjct: 1619 RGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVE 1678
Query: 1628 TLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKK 1687
LLA +D +DLAS NLLKKHQLLE ++ A ED LKDLN+ A+ L++S F+ Q+ K
Sbjct: 1679 ALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDK 1738
Query: 1688 KDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQG 1747
+D +N RF ++ +AA+ KL E++ L QFF+D+DDEESWI+EK + V S+DYGRDL G
Sbjct: 1739 RDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTG 1798
Query: 1748 VQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKEL 1807
VQNL KKHKRLE EL AHEPAIQ VLD +KL D +G+EEIQ RLAQFVEHW++LK+L
Sbjct: 1799 VQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQL 1858
Query: 1808 AKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALEND 1867
A ARG +LEESLEY QF+ N EEEEAWINEK L D GDTLAA Q LL KHEA E D
Sbjct: 1859 AAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETD 1918
Query: 1868 FAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDD 1927
F VH+ RV +VC G+D++ K + ISSK++ LN K L KA A K +L+++
Sbjct: 1919 FTVHKDRVNDVCTNGQDLIKK---NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN 1975
Query: 1928 YAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPE 1987
AF +FNWKADVVE+WI +KE SLKT+ G DL TLL KQ+T DA LQ+FQQE +
Sbjct: 1976 SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN 2035
Query: 1988 ITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVE 2047
IT LKD+L++A+H QSKAIE R+A+L+KRW QLL SA ++KLLE Q +K EDLF+
Sbjct: 2036 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2095
Query: 2048 FAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQ 2107
FA KASA N+W E EE+L++PV C SL EI+ L++ H+ F +SL+ AQADF L ELD+
Sbjct: 2096 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR 2155
Query: 2108 QIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNAS 2167
QIK+ V S+PYTW T+E LE TW++L II+ERE ELQKE+ RQ +N ++ QEF Q+A+
Sbjct: 2156 QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN 2215
Query: 2168 TFLQWILETRAYFLDGS-LLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDA 2226
F QWI ETR Y LDGS +++E+GTLESQLEA KRK +EI+AM+ QL KI DLG +E+A
Sbjct: 2216 AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA 2275
Query: 2227 LILDIKY---STIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHF 2283
LILD KY ST+GLAQQWDQL QLG+RMQHNLEQQIQA++ GV+EE LKEFS ++KHF
Sbjct: 2276 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF 2335
Query: 2284 DENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFL 2343
D++ +GRL H+EF+SCLR L Y LPMVEE E +P+FE LD VDP R G+VSL++Y AF+
Sbjct: 2336 DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM 2395
Query: 2344 IDKESENIKSSDEIENAFQAL-AEGKSYITKEDMKQALTPEQVSFCATHMQQYMDPRGRS 2402
I +E+EN+KSS+EIE+AF+AL +EGK Y+TKE++ Q LT EQ +C +HM+ Y+D +GR
Sbjct: 2396 ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE 2455
Query: 2403 HLSGYDYVGFTNSYFGN 2419
+ +DYV FT S F N
Sbjct: 2456 LPTAFDYVEFTRSLFVN 2472
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 2684 bits (6958), Expect = 0.0
Identities = 1371/2482 (55%), Positives = 1793/2482 (72%), Gaps = 77/2482 (3%)
Query: 10 VESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWI 69
++ SG KVLETAE+IQERRQ+VL RY FKE R QKLEDSY Q F+RDA++L KWI
Sbjct: 1 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI 60
Query: 70 MEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEET 129
EK+ I +D++Y+DPTN+QGK QKHQ+ EAEVQ S + +L++T + GH A E
Sbjct: 61 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
Query: 130 KAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGED 189
+ + EL W+LLLE EKG +LL+A K QY++EC D+++WI DKEAI TS ELG+D
Sbjct: 121 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD 180
Query: 190 WERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERL 249
E EVL KKFE+FQ ++ A E RV EVNQ+A + +E HP+ LI++KQ+EVNAAW+RL
Sbjct: 181 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL 240
Query: 250 RGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGL 309
+GLALQRQ L AA +QRF RDV E I WIKEKE ++ S+D+G+DL + + L H+GL
Sbjct: 241 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300
Query: 310 ERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQAT 369
ER+LA + DKVK LCA+A++L SHP A QIQ +E+L+++WE IR LA R+ +L +
Sbjct: 301 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
Query: 370 YWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSA 429
Y RF +DF +L+ W+ E A INADEL +DVAG E LLDRHQ+HK EID+++D F+SA
Sbjct: 361 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420
Query: 430 DETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVD 489
DE+GQ L+ A H ASDEVREK+ +L ALLELW+ R +QYEQC+D LFYRD+EQVD
Sbjct: 421 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
Query: 490 SWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYD 549
+WMS+QEAFL NEDLG+SL S EALL+KHEDFE++ +AQEEKI +D+ ATKLI ++HY
Sbjct: 481 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
Query: 550 SENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDED 609
E++ RD LL+RR+AL E+A RR L +S LQ+ + DSD+LK+W+N+K K A DE
Sbjct: 541 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600
Query: 610 YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLW 669
YKD NL+ +VQK Q FE EL+ N+++++ ++K GQ++I+ HYA D V R++EV SLW
Sbjct: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
Query: 670 EELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729
++LLEAT+ KG +L EANQQ QF N ED++ WL +VE + S+DYGK L VQN +KH
Sbjct: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
Query: 730 GLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKL 789
LLE+ VAA QD++D +T A F++ GH D+++I+ +QE+LV R+EALKEP+ RK+KL
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
Query: 790 LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849
D L LQ + RD EDEE WI+E EP A ST GKDLI + LL +H+ + IA HEPRI
Sbjct: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
Query: 850 QEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLH 909
+ +T++GN MVEEGHFAAEDV +++ LNQ E+L+A+A++R+ DLE ++Q QQY AD +
Sbjct: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 910 EAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQ 969
EAE+W+REKEPIV +T+YG DE++A ALLKKHEA + DL+++G S++ALR QA +C +QQ
Sbjct: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSC-RQQ 959
Query: 970 AAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAV 1029
AP + G++ V+ALYD+Q +SPREVTMKKGD+LTLL+S NKDWWKVE D QG VPA
Sbjct: 960 VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019
Query: 1030 YVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQ--------------------YRSLLD 1069
YV++L + + EE G+I RQEQI+NQ Y SLL+
Sbjct: 1020 YVKKLDPAQ-SASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLE 1078
Query: 1070 RAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKA----ENTGVELDDVWELQKKFDEFQK 1125
E+R+ L + +F+L EA ++ +WI EK+A E G +L+ V LQKKFD+FQK
Sbjct: 1079 LGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQK 1138
Query: 1126 DLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQ-------------------------- 1159
DL NE RL+DINKVA+DL EGL+ E ++Q
Sbjct: 1139 DLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLM 1198
Query: 1160 -----------ELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSA 1208
ELN RW SLQ+LA+E+ QLLGSAH V+ FHR+AD+TKE IE+K QAL+
Sbjct: 1199 VHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNT 1258
Query: 1209 ADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELN 1268
+ G DL SVQALQR+HEGFERDL LGDKV LGETAERL +SHP++ EDLQ + ELN
Sbjct: 1259 DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
Query: 1269 EAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILL 1328
+AW L R RK L ++ FLS RDL +WI+ I G+VSS ELA+D+TG E LL
Sbjct: 1319 QAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL 1378
Query: 1329 ERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRK 1388
ERHQEHR +++A A TFQA E F +L+ GH+ASPEI++KL + ER DLEKAW +R+
Sbjct: 1379 ERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRR 1438
Query: 1389 KILDQCLELQMFQGNCDQVESWMVARENSLRSDDK-SSLDSLEALMKKRDDLDKAITAQE 1447
+LDQCLELQ+F +C+Q E+WM ARE L ++DK SLDS+EAL+KK +D DKAI QE
Sbjct: 1439 MMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQE 1498
Query: 1448 GKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYR 1507
KI L+ FA+ LIA HYAK +I++R VLDRW+ LKAQ+I++R+KLG+ L+QF R
Sbjct: 1499 EKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSR 1558
Query: 1508 DLEELEEWISEMLPTACDESYKDATNIQ-----RKYLKHQTFAHEVDGRSEQVHGVINLG 1562
D++E+E WISE L TA DESYKD TNIQ K+ KHQ F E+ ++++ GVI++G
Sbjct: 1559 DVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMG 1618
Query: 1563 NSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFW 1622
NSLIE AC G+E+A+K +L L + W L++++ +K +KL EA++QQ FNT I+DF+FW
Sbjct: 1619 NSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFW 1678
Query: 1623 LSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVD 1682
LSE E LLA +D +DLAS NLLKKHQLLE ++ A ED LKDLN+ A+ L++S F+
Sbjct: 1679 LSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTS 1738
Query: 1683 QIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYG 1742
Q+ K+D +N RF ++ +AA+ KL E++ L QFF+D+DDEESWI+EK + V S+DYG
Sbjct: 1739 QVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYG 1798
Query: 1743 RDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWE 1802
RDL GVQNL KKHKRLE EL AHEPAIQ VLD +KL D +G+EEIQ RLAQFVEHW+
Sbjct: 1799 RDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWK 1858
Query: 1803 KLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHE 1862
+LK+LA ARG +LEESLEY QF+ N EEEEAWINEK L D GDTLAA Q LL KHE
Sbjct: 1859 ELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHE 1918
Query: 1863 ALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKL 1922
A E DF VH+ RV +VC G+D++ K + ISSK++ LN K L KA A K
Sbjct: 1919 AFETDFTVHKDRVNDVCTNGQDLIKK---NNHHEENISSKMKGLNGKVSDLEKAAAQRKA 1975
Query: 1923 QLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQ 1982
+L+++ AF +FNWKADVVE+WI +KE SLKT+ G DL TLL KQ+T DA LQ+FQQ
Sbjct: 1976 KLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQ 2035
Query: 1983 ERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE 2042
E + IT LKD+L++A+H QSKAIE R+A+L+KRW QLL SA ++KLLE Q +K E
Sbjct: 2036 EGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVE 2095
Query: 2043 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCL 2102
DLF+ FA KASA N+W E EE+L++PV C SL EI+ L++ H+ F +SL+ AQADF L
Sbjct: 2096 DLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQL 2155
Query: 2103 LELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEF 2162
ELD+QIK+ V S+PYTW T+E LE TW++L II+ERE ELQKE+ RQ +N ++ QEF
Sbjct: 2156 AELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEF 2215
Query: 2163 EQNASTFLQWILETRAYFLDGS-LLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGD 2221
Q+A+ F QWI ETR Y LDGS +++E+GTLESQLEA KRK +EI+AM+ QL KI DLG
Sbjct: 2216 AQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGA 2275
Query: 2222 NLEDALILDIKY---STIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFST 2278
+E+ALILD KY ST+GLAQQWDQL QLG+RMQHNLEQQIQA++ GV+EE LKEFS
Sbjct: 2276 AMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSM 2335
Query: 2279 IYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLED 2338
++KHFD++ +GRL H+EF+SCLR L Y LPMVEE E +P+FE LD VDP R G+VSL++
Sbjct: 2336 MFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQE 2395
Query: 2339 YTAFLIDKESENIKSSDEIENAFQAL-AEGKSYITKEDMKQALTPEQVSFCATHMQQYMD 2397
Y AF+I +E+EN+KSS+EIE+AF+AL +EGK Y+TKE++ Q LT EQ +C +HM+ Y+D
Sbjct: 2396 YMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVD 2455
Query: 2398 PRGRSHLSGYDYVGFTNSYFGN 2419
+GR + +DYV FT S F N
Sbjct: 2456 GKGRELPTAFDYVEFTRSLFVN 2477
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 567 bits (1462), Expect = e-161
Identities = 512/2247 (22%), Positives = 965/2247 (42%), Gaps = 112/2247 (4%)
Query: 36 QSFKERVAERGQKLEDSYHLQVFKRDADDL-GKWIMEKVNILTDKSYEDPTNIQGKYQKH 94
Q K +R Q L++ LQ F R+ D + + D ED Q+H
Sbjct: 1156 QELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQH 1215
Query: 95 QSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQL 154
+ + T L E+ H A + ++ ++ W L + ++ QL
Sbjct: 1216 REFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQL 1275
Query: 155 LRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRV 214
L +L+ Q++ Q+ A++++W+ +K +A G + L K+ E + EL+A V
Sbjct: 1276 LASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-KRHEAAESELLATRRHV 1334
Query: 215 VEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVT 274
+ Q E IQ++ + + WE L +R L A ++ R +
Sbjct: 1335 EALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQ 1394
Query: 275 EAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSH 334
+A + +++ E L S + G+DL +S+ L H+ LE ++ K+ L + A + S
Sbjct: 1395 DAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS- 1453
Query: 335 PSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAIN 394
P I E + + E ++ R +LQA+ H+F + W+ E +
Sbjct: 1454 ----PAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGS 1509
Query: 395 ADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEIL 454
+ G + L +H++ + E+ ++ + Q +G+ L + H + + E+ + L
Sbjct: 1510 PTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQEL 1569
Query: 455 DNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEAL 514
+ +W L + R + +Q + F ++ D +++ W+ + + + D G + L
Sbjct: 1570 EGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRL 1629
Query: 515 LQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATR 574
+ KH+ +E + +D+TA L G + + + + +++ L + AL+E AATR
Sbjct: 1630 INKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRV--VQERLREQLRALQELAATR 1687
Query: 575 RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDY--KDIQNLKSRVQKQQVFEKELAV 632
R L+ +L L + +++DL+ W+ +K+ A + +D ++ K F+ ++ +
Sbjct: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
Query: 633 NKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQF 692
++ + + ++E GH A V R ++ + W EL E T+ +G L + L+
Sbjct: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRV 1807
Query: 693 ENNAEDLQRWLEDVEWQVTS--EDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLA 750
DL L V+ + TS + + L ++ +LR H LE + + Q+ L + A
Sbjct: 1808 HR---DLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETA 1864
Query: 751 AYFEEI-GHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWI 809
+++ P + ++ RQ+++ + L+ + R+ +L L D +W
Sbjct: 1865 GRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWA 1924
Query: 810 QETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAED 869
++ + L+ H+ + + + E Q+ T+ G + + ++
Sbjct: 1925 ARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE 1984
Query: 870 VASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGA 929
V +++L + + AR+Q L+A Q Q +L + E + +E + + G+
Sbjct: 1985 VQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGS 2044
Query: 930 DEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQ 989
E L++KHE FL L + ALR + ++ + + ++R+ +
Sbjct: 2045 SVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAE 2104
Query: 990 ARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRR-----LAHDEFPMLPQ 1044
+R T ++ +DW + A + VP +R L H F Q
Sbjct: 2105 SRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQ 2164
Query: 1045 RRRE------------------EPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFL 1086
E G ++QR + + + L R + L R N FL
Sbjct: 2165 AHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN-FL 2223
Query: 1087 LAYEAGDMLE-WIQEKKAE----NTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVA 1141
+ D+ E WIQEK+ + + G +L+ +L+++ EF+ + + I ++
Sbjct: 2224 EFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS 2283
Query: 1142 DDLLFEGLLTPEGAQI----RQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKE 1197
D L PE +I R +LN+RW S +Q L A + V RE D+ +
Sbjct: 2284 DLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTK 2343
Query: 1198 QIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDAT 1257
+I++K + A D G DL SVQ L R+HE ER++ P+ +V L RL + P+A
Sbjct: 2344 RIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAA 2403
Query: 1258 EDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQEL 1317
L+ ++ E+ E+W L+ R + R+E+L+ L +A+ LQ + + +VS+Q L
Sbjct: 2404 HGLRHRQQEVAESWWQLRSRAQKRREALDA-------LHQAQKLQAMLQEL--LVSAQRL 2454
Query: 1318 AEDL-------TGIEI--LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEK 1368
+ + +E +LE HQE +A++++ + +L+ +GH S +I +
Sbjct: 2455 RAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQ 2514
Query: 1369 KLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDK-SSLD 1427
L ++ E LE AW++ + L Q LELQ+F + +++E W+ ++E+SL S+ L
Sbjct: 2515 VLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLA 2574
Query: 1428 SLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKA 1487
+E L+ K L+ + Q GKI+ LE A L H + R Q +L R +AL
Sbjct: 2575 PMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
Query: 1488 QLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHE 1547
Q R +L + L+ F +D +E+ W+ E A +E D + + K Q F E
Sbjct: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAE 2694
Query: 1548 VDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEAS 1607
+D Q + G L++ EA++E+LE+L W L + + K KL +A
Sbjct: 2695 LDASMHQQQELQREGQRLLQGG--HPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC 2752
Query: 1608 RQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLN 1667
R S+ + E WL E L + L G LL + LE + + + L
Sbjct: 2753 EALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALL 2812
Query: 1668 TLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEES 1727
A+ + G + ++ + +RF +++E L+ L +FF+D D+E +
Sbjct: 2813 GQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
Query: 1728 WIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQ 1787
W++EKL ++QDYG+ L V++L ++H+ LE E+ +HE + VL KL
Sbjct: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
Query: 1788 EEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDC 1847
E+ R+ Q + L+ A R L L+++ E QF+ E +W+ E+ + D
Sbjct: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
Query: 1848 GDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALN 1907
G + ATQ+LL + EA + D R++ + Q +L ++ ++ ++ ++++A+
Sbjct: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERL-QQTAALLES--RKNPESPKVLAQLQAVR 3049
Query: 1908 EKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLL 1967
E L + A L++ + + +++AW+ K + ++ G DL L
Sbjct: 3050 EAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLE 3109
Query: 1968 AKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVH 2027
K D +QS Q ++ + L L + I+ + + + WE+L +A
Sbjct: 3110 EKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKAR 3169
Query: 2028 RQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCV-------SLNEIRQ 2080
+ L AH+ + +++ + E + SL+ +R
Sbjct: 3170 TENLAA---------------AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRT 3214
Query: 2081 LQKDHEDFLASLARAQADFKCLLELDQQIKALGV--PSSPYTWLTVEVLERTWKHLSDII 2138
LQ+ H L +A K + L + LG P++P V + W L
Sbjct: 3215 LQQQHRRLEREL---EAMEKEVARLQTEACRLGQLHPAAPGGLAKV---QEAWATLQAKA 3268
Query: 2139 EEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEA 2198
+ER Q L + A+ CQE L W E + L ++ E L
Sbjct: 3269 QERGQWL-AQAAQGHAFLGRCQE-------LLAWAQERQELASSEELAEDVAGAEQLLGQ 3320
Query: 2199 NKRKQKEIQAMKRQLTKIVDLGDNLED 2225
++ +EI+ + Q + G L D
Sbjct: 3321 HEELGQEIRECRLQAQDLRQEGQQLVD 3347
Score = 556 bits (1433), Expect = e-158
Identities = 400/1444 (27%), Positives = 684/1444 (47%), Gaps = 96/1444 (6%)
Query: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYED 83
+++R +L R KE RG L S + F + A WI L K
Sbjct: 2085 VRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL--KEPVP 2142
Query: 84 PTNIQGKYQ---KHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLW 140
P +++ K + KHQ+ EAEVQ +M+ + K E H E ++ LR W
Sbjct: 2143 PGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHW 2202
Query: 141 DLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKF 200
+ L + +G +L F +++Q WI +KE +LG+D E L ++
Sbjct: 2203 EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRL 2262
Query: 201 EDFQVELVAK---EGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQ 257
+F+ + + ++ + + + ++ +I +++++N W G L+ Q
Sbjct: 2263 REFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQ 2322
Query: 258 KALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMS 317
+ L A + R++ + I+EKE ++ + D GKDL + + L H+ LER + +
Sbjct: 2323 QQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQ 2382
Query: 318 DKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSS 377
+V+ L + +L P A ++ ++++ SW +R+ A R E L A + + +
Sbjct: 2383 AQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQA 2442
Query: 378 DFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLV 437
EL A ++ P +L+ HQ+ K E+DS+ D A TGQ L+
Sbjct: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502
Query: 438 NANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEA 497
A H S ++R+ + L+ ++L W E Q +Q L+ LF E+++ W+ +E
Sbjct: 2503 TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562
Query: 498 FLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIR 557
L +E L + L E LL KH+ E Q KI ++ TA L H ++++
Sbjct: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRC 2622
Query: 558 DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLK 617
+L R++AL +A TRR L+E LQ +DS ++ W+ +K +A +E D L
Sbjct: 2623 QAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLP 2682
Query: 618 SRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATK 677
+++QKQQ F+ EL + Q + +Q+ GQ +++GGH AS+ + RL E+ +LW EL + ++
Sbjct: 2683 AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQ 2742
Query: 678 QKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVA 737
+K +L +A + L+ + E+L+ WLE +E ++ + G+ L V L LE+AV
Sbjct: 2743 KKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVD 2802
Query: 738 ARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQL 797
+ Q + L A F GH ++D+ + L+ RF++L+EPL R+ L L
Sbjct: 2803 KKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLK 2862
Query: 798 ICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGN 857
RD ++E AW+QE P A + G+ L A + L +H+ + ++SHE + + G
Sbjct: 2863 FFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGY 2922
Query: 858 KMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIRE 917
K+V+ GHFAA +VA+RV+ L + M LRA AARR+ L+ + QQ+L +L EA +W+ E
Sbjct: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
Query: 918 KEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVA 977
+ ++D+ + G EA ALL++ EA DL +F ++ L QQ AA +E
Sbjct: 2983 RGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERL--------QQTAALLESRK 3034
Query: 978 GEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHD 1037
+ SP+ VL L ++ R AH
Sbjct: 3035 NPE-----------SPK--------VLAQLQAV----------------------REAHA 3053
Query: 1038 EFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEW 1097
E RR E G+ Q Q Q+ ER LL W
Sbjct: 3054 EL----LRRAEARGHGLQEQLQLHQL---------ERETLLLD---------------AW 3085
Query: 1098 IQEKKA----ENTGVELDDVWELQKKFDEFQKDLNT-NEPRLRDINKVADDL-LFEGLLT 1151
+ K A ++ G +L+ V L++KFD F+K++ + + ++ + K+A L
Sbjct: 3086 LTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRY 3145
Query: 1152 PEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADP 1211
P R + + W L + + + L +AH V F + A + + ++++K + D
Sbjct: 3146 PHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDG 3205
Query: 1212 GSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAW 1271
G L SV+ LQ++H ER+L + +V L A RL + HP A L + + EAW
Sbjct: 3206 GHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAK----VQEAW 3261
Query: 1272 EDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERH 1331
LQ + ++R + L +A + + FL + ++L W + SS+ELAED+ G E LL +H
Sbjct: 3262 ATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQH 3321
Query: 1332 QEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKIL 1391
+E ++ Q L +L+D+ H S E+ + LQ ++ +LE+AW R +
Sbjct: 3322 EELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRC 3381
Query: 1392 DQCLELQMFQGNCDQVESWMVAREN-SLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKI 1450
+ LQ + +Q E+W+ E L+ D S+ +E L+ + DL+K + AQE K
Sbjct: 3382 AESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKF 3441
Query: 1451 TDLE 1454
++
Sbjct: 3442 AQMQ 3445
Score = 448 bits (1153), Expect = e-125
Identities = 492/2300 (21%), Positives = 943/2300 (41%), Gaps = 219/2300 (9%)
Query: 26 ERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY-EDP 84
ER + V +Q + RV RG +L+ + + + DA + W+ E+ + L S +D
Sbjct: 683 ERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQ 742
Query: 85 TNIQGKYQKHQSLEAEVQTKSRLMSELEK------TREERFTMGHSAH------------ 126
+ ++H LE ++ + + LE+ R FT+ +
Sbjct: 743 AAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPW 802
Query: 127 EETKAH------------------------IEELRHL---WDLLLELTLEKGDQLLRALK 159
E H ++ HL ++ L L + +L A+
Sbjct: 803 SEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMA 862
Query: 160 FQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQ 219
+ C ++ W+ + + V+ D EV+ K+E+F L +G EV+
Sbjct: 863 LFGFCSSCGELQLWLEKQTVLLQRVQPQAD--TLEVMQLKYENFLTALAVGKGLWAEVSS 920
Query: 220 YANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQW 279
A + + + IQ +Q E++ W +L L ++ L+++ + F ++
Sbjct: 921 SAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQ 980
Query: 280 IKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAP 339
+++ L + G +SE H+ + ++ V+ +V L + K+ +++
Sbjct: 981 LRDVLLQLEALQPG----SSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQ 1036
Query: 340 QIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELP 399
+Q E L + ++ R + T F + +L W A + + E+
Sbjct: 1037 PLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVS 1096
Query: 400 TDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWT 459
DVA + LL HQ EI + +R Q D Q + + S EV + +L
Sbjct: 1097 VDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQ 1156
Query: 460 ALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHE 519
L LW++R + ++ L+ F R+ + + + +A+L ++LG + A +LLQ+H
Sbjct: 1157 ELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHR 1216
Query: 520 DFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLK 579
+F + + + KL+ H + ++ + A+ L+ ++ RRR L
Sbjct: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL 1276
Query: 580 ESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLEN 639
SL LQ+ +D +L W+ +K +A E +N+ +++ + E EL + +E
Sbjct: 1277 ASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEA 1336
Query: 640 IQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDL 699
+Q+ G+E++ +++ TRL + S WE L ++G +L +A QQ Q +D
Sbjct: 1337 LQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDA 1396
Query: 700 QRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHP 759
+ LE +E + S + G+ L Q ++H LES ++ L +A G
Sbjct: 1397 KEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAH-----GMA 1451
Query: 760 DSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATST 819
S I + + R E L+ LA R +L + L C + E +W+ E P + T
Sbjct: 1452 ASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
Query: 820 YLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQ 879
+ L ++ L +H+ + + +H+ ++Q + G + GH A+ + + + L
Sbjct: 1512 SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEG 1571
Query: 880 NMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLK 939
+ L R L+ V FQQY D+ E E W+ EK P+V + +YG DE A L+
Sbjct: 1572 HWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN 1631
Query: 940 KHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGE---QRVMALYDFQARSPREV 996
KH+A +L + SM+ L A + + V E +++ AL + A RE+
Sbjct: 1632 KHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDREL 1691
Query: 997 --TMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNIT 1054
T++ + L EA D QG + + + P+
Sbjct: 1692 EGTLRLHEFLR------------EAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
Query: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVW 1114
+ Q Q+E + + LL+R + AG M+ ++ ++ ++W
Sbjct: 1740 KFQHQVEMGSQRVA-ACRLLAESLLER------GHSAGPMV----RQRQQDLQTAWSELW 1788
Query: 1115 ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQ-----IRQELNSRWGSLQ 1169
EL + +D T RD+ +V + + P + +L S G +
Sbjct: 1789 ELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLER 1848
Query: 1170 RLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFE 1229
L +RQL +E +T +++K C PG +VQ
Sbjct: 1849 ELVGTERQL-----------QELLETAGRVQKLC-------PGPQAHAVQ---------- 1880
Query: 1230 RDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQ 1289
QRQ+ + +AW LQ R + R+ L A+
Sbjct: 1881 -------------------------------QRQQ-AVTQAWAVLQRRMEQRRAQLERAR 1908
Query: 1290 KFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALE 1349
F + RD +W + + + +E +++ + + L HQ RA++EA +Q
Sbjct: 1909 LLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQAT 1968
Query: 1350 DFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVES 1409
+ + + + E++++L+A++ +RD + + W ++++ L + Q+F C ++E
Sbjct: 1969 QLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEE 2028
Query: 1410 WMVARENSLRSDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAK 1468
+ A+E SL++ SS++ +E L++K + K +TAQ+ K L ++L +
Sbjct: 2029 ILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTL------RR 2082
Query: 1469 EEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWI-------SEMLP 1521
+ RL +L R +K L + F + + E+WI E +P
Sbjct: 2083 PRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVP 2142
Query: 1522 TACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQ 1581
D + + LKHQ F EV E + V G +L+ S E + ++
Sbjct: 2143 PG------DLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGE--VSQR 2194
Query: 1582 LEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLAS 1641
L+ L++HW+ L + +G++L + F + E W+ E E + + D +DL
Sbjct: 2195 LQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEH 2254
Query: 1642 AGNL---LKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNV 1698
L L++ + + ++ ++ L+ L + V I +++ +N R+ +
Sbjct: 2255 CLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASF 2314
Query: 1699 QELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRL 1758
+ ++L+ A + ++LD+ I+EK + + D G+DL+ VQ LL+KH+ L
Sbjct: 2315 HGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEEL 2374
Query: 1759 EGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEES 1818
E E+ + ++++ +L ++ ++ R + E W +L+ A+ R
Sbjct: 2375 EREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKR------- 2427
Query: 1819 LEYLQFMQNAEEEEAWINE--KNALAVRGDCGDTLAATQS------LLMKHEALENDFAV 1870
E L + A++ +A + E +A +R DT A +S +L +H+ + +
Sbjct: 2428 REALDALHQAQKLQAMLQELLVSAQRLRAQM-DTSPAPRSPVEARRMLEEHQECKAELDS 2486
Query: 1871 HETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAF 1930
+ + G+ +L + +I + L ++ SL A +LQL+
Sbjct: 2487 WTDSISLARSTGQQLLT---AGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL 2543
Query: 1931 QEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITD 1990
Q F + +E W+ KE SL + G L LL K L+ L+ Q ++ +
Sbjct: 2544 QLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLE-VQAGKISALEA 2602
Query: 1991 LKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLE-KQLP--LQKAEDLFVE 2047
L H ++++ R A+L R E L + R +L E +QL LQ ++++
Sbjct: 2603 TARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAW 2662
Query: 2048 FAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQ 2107
K +EE L + + QLQK ++F A L + + L Q
Sbjct: 2663 LREKNLV------ALEEGLLDTAMLPA-----QLQK-QQNFQAELDASMHQQQELQREGQ 2710
Query: 2108 QIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQK--EEARQVKNFEMCQEFEQN 2165
++ G P+S +E L W L D +++ +LQK E R ++ E + + +
Sbjct: 2711 RLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770
Query: 2166 ASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLED 2225
L+ +A G LL LE+ ++ +K ++ +A+ Q V G
Sbjct: 2771 IEVELRAPTVGQALPGVGELLGTQRELEAAVD---KKARQAEALLGQAQAFVREG----H 2823
Query: 2226 ALILDIKYSTIGLAQQWDQL 2245
L D++ L Q++ L
Sbjct: 2824 CLAQDVEEQARRLLQRFKSL 2843
Score = 430 bits (1106), Expect = e-120
Identities = 477/2265 (21%), Positives = 929/2265 (41%), Gaps = 133/2265 (5%)
Query: 5 PKETVVESSGPKVLET----AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKR 60
P+ + + G K++++ A ++E+ Q + ++ + R +R ++L S LQ +K+
Sbjct: 1227 PRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQ 1286
Query: 61 DADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFT 120
D +L +W+ EK + + NI ++H++ E+E+ R + L++ E +
Sbjct: 1287 DVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLS 1346
Query: 121 MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAI 180
E+ + ++ LR W+ L E+GD+L +A + +Q +++ D E + E
Sbjct: 1347 RRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGA 1406
Query: 181 ATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECA------EENHPDLPL 234
S E G+D ++ L K+ + + E ++ + A+ A EE L
Sbjct: 1407 LQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRR 1466
Query: 235 IQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGK 294
++ Q + +RGL LQ L +L + + W+ E P + Y +
Sbjct: 1467 LELLQGHL-----AIRGLQLQASVELHQFCHLSNME------LSWVAEHMPHGSPTSYTE 1515
Query: 295 DLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEH 354
L ++ L HK L+ + +V+ + + L S A I E ++L W
Sbjct: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAE 1575
Query: 355 IRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQ 414
+ +R + LQ + ++ D EL GW+ EK +++ + D A L+++HQ
Sbjct: 1576 LERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQA 1635
Query: 415 HKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQ 474
+ E+ Y + D+T Q L E ++ R E L AL EL R R+ E
Sbjct: 1636 LQEELAIYWSSMEELDQTAQTLTGP--EVPEQQRVVQERLREQLRALQELAATRDRELEG 1693
Query: 475 CLDFHLFYRDSEQVDSWM-SRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKII 533
L H F R++E + W+ S+++A E LG A L K F+ +++
Sbjct: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVA 1753
Query: 534 TVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDD 593
A L+ H ++ + L L E R L+++ +++ D +
Sbjct: 1754 ACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLE 1813
Query: 594 LKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTG---QEMIEG 650
+ + +K + +D+ L+++++ Q E+EL + QL+ + +T Q++ G
Sbjct: 1814 VLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPG 1873
Query: 651 GHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQV 710
+ V R V W L +Q+ QL A +F D W V +
Sbjct: 1874 PQ--AHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDL 1931
Query: 711 TSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQES 770
E+ + + +L H L + + AR+ T L +K+++ +
Sbjct: 1932 QVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRA 1991
Query: 771 LVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKK 830
L + + + + A ++++L QL R+ E + E S ++ LG + ++
Sbjct: 1992 LQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQ 2051
Query: 831 LLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAAR 890
L+ +H V L+ + + + + + ER + V R+ L Q ++ A
Sbjct: 2052 LIRKHEVFLKVLTAQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAES 2105
Query: 891 RQNDLEANVQFQQYLADLHEAETWIRE-----KEPI----------------VDNTNYGA 929
R + L A++ + +AE WI+ KEP+ A
Sbjct: 2106 RGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA 2165
Query: 930 DEEAAGALLKKHEAFLLDLN-SFGDSMKALRNQANACQQ-QQAAPVEGVAGEQRVMALYD 987
EE ++ KK EA L + G+ + L+ + +QA + G E R L +
Sbjct: 2166 HEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL-E 2224
Query: 988 FQAR--------SPREVTMKKGDV---LTLLSSINKDWWKVEAADHQGIVPAVYVRRLAH 1036
F R +EV M GD+ L + + + V +R ++
Sbjct: 2225 FLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS- 2283
Query: 1037 DEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLE 1096
D L R EE I QR+ Q+ N++ S +++L +L+ E ++ +
Sbjct: 2284 DLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTK 2343
Query: 1097 WIQEK----KAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTP 1152
IQEK +A + G +L+ V L +K +E +++++ + ++ + + L
Sbjct: 2344 RIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAA 2403
Query: 1153 EGAQIR-QELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADP 1211
G + R QE+ W L+ A ++R+ L + H + + ++ + +
Sbjct: 2404 HGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPA 2463
Query: 1212 GSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAW 1271
+ + H+ + +L D +++ T ++L + + D+++ L +
Sbjct: 2464 PRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQEL 2523
Query: 1272 EDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERH 1331
L+G ++ + L +A + LFLS ++ W+ S ++S+ L + L +E LL +H
Sbjct: 2524 SSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKH 2583
Query: 1332 QEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKIL 1391
+ D+E +A ALE + L GH + + QA+ L ++ L + R+ L
Sbjct: 2584 KMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRL 2643
Query: 1392 DQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDS--LEALMKKRDDLDKAITAQEGK 1449
++ +LQ F + +V +W+ RE +L + ++ LD+ L A ++K+ + + A +
Sbjct: 2644 EELRQLQAFLQDSQEVAAWL--REKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQ 2701
Query: 1450 ITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDL 1509
+L+ + L+ H A E I RL+ + W L+ + KL + R +
Sbjct: 2702 QQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSM 2761
Query: 1510 EELEEWISEMLPTACDESYKDATNIQRKYLKHQ-TFAHEVDGRSEQVHGVINLGNSLIEC 1568
EELE W+ + + A + L Q VD ++ Q ++ + +
Sbjct: 2762 EELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVRE 2821
Query: 1569 SACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAET 1628
C + ++EQ +L + + L E ++ L S +F + W+ E
Sbjct: 2822 GHCLAQD--VEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLP 2879
Query: 1629 LLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688
L A +D + L++ +L ++HQ LE EM + E + + L+ +G F ++ +
Sbjct: 2880 LAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARV 2939
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748
+ K +++ AA L++A QF +L + SW+ E+ + S+D G +
Sbjct: 2940 QQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEAT 2999
Query: 1749 QNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELA 1808
Q LL++ + + +L A P I+ + A L+ + ++ +L E +L A
Sbjct: 3000 QALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRA 3059
Query: 1809 KARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDF 1868
+ARG L+E L+ Q + +AW+ K A A D G L + L K +A +
Sbjct: 3060 EARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEV 3119
Query: 1869 -AVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDD 1927
++ + +V + + + + S+IEA E+ L +AI A L
Sbjct: 3120 QSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWER---LDQAIKARTENLAAA 3176
Query: 1928 YAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQE--RL 1985
+ F A ++ + +K +K G L TL + L+ L++ ++E RL
Sbjct: 3177 HEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARL 3236
Query: 1986 PEITDLKDKLISAQHNQSKAIEERYAAL----LKRWEQLLEASAVHR-----QKLL---E 2033
+L A ++E +A L +R + L +A+ H Q+LL +
Sbjct: 3237 QTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQ 3296
Query: 2034 KQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLA 2093
++ L +E+L + A L E +E + L + Q D+ F+++
Sbjct: 3297 ERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEV 3356
Query: 2094 RAQADFKCLLELDQQIK------ALGVPSSPYTWLTVEVLER---------TWKHL---- 2134
+CL EL+ +++ AL +W ++ +R W+ L
Sbjct: 3357 T-----ECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKP 3411
Query: 2135 --------SDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQ 2171
+++ R Q+L+K A Q + F Q+ E LQ
Sbjct: 3412 DYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQ 3456
Score = 391 bits (1005), Expect = e-108
Identities = 375/1676 (22%), Positives = 707/1676 (42%), Gaps = 111/1676 (6%)
Query: 613 IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEEL 672
+ +++ VQ+ + E + + + + + + + + +++ +V R EV W+ L
Sbjct: 424 LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
Query: 673 LEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLL 732
L+ + + Q+ + L E LE+++ S G+ LAEV L++H LL
Sbjct: 484 LQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLL 543
Query: 733 ESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDL 792
E+ V+A V L A + + ++A+ +L ++L + R+ L
Sbjct: 544 EAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQT 603
Query: 793 LHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEI 852
L R+ E+EEAW++E + LG+DL L +H+ + + H+ ++
Sbjct: 604 LQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDL 663
Query: 853 TERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAE 912
RG + D R +++ + L+ R R L+ + QY AD EA
Sbjct: 664 VRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAA 723
Query: 913 TWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAP 972
+W+RE+ ++ + G D+ AA LL++H L +F ++ L Q
Sbjct: 724 SWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQ----------- 772
Query: 973 VEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVR 1032
G A R A SP +++ N W EA+ H G A +
Sbjct: 773 --GRAASARASLFTVNSALSPPGESLR-----------NPGPWS-EASCHPGPGDAWKMA 818
Query: 1033 RLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAG 1092
A + +P I Q Q+ + Y SL A+ RR RL + F G
Sbjct: 819 LPAEPDPDF-------DPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCG 871
Query: 1093 DMLEWIQEKKA--ENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLL--FEG 1148
++ W++++ + + D + +Q K++ F L + +++ A+ L + G
Sbjct: 872 ELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPG 931
Query: 1149 LLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEV--FHREADDTKEQIEKKCQAL 1206
T Q ++EL+ RWG L+ L E+ L AH+VEV F +E T+ Q+ L
Sbjct: 932 NSTQIQRQ-QEELSQRWGQLEALKREKAVQL--AHSVEVCSFLQECGPTQVQLRDVLLQL 988
Query: 1207 SAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKME 1266
A PGS + ALQ ++ + L +V L ++ E ++ LQ Q
Sbjct: 989 EALQPGSSEDTCHALQLA----QKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVET 1044
Query: 1267 LNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEI 1326
L + +Q + R E Q FL +++ L W S+ + S+E++ D+ +
Sbjct: 1045 LQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQR 1104
Query: 1327 LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEK 1386
LL HQ+ ++ Q L+ S + S E+ L+ + + +L+ WE+
Sbjct: 1105 LLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQ 1164
Query: 1387 RKKILDQCLELQMF-------QGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDL 1439
R++ L + LELQ F C ++W+ ++L D + +L +L+++ +
Sbjct: 1165 RQQWLQEGLELQKFGREVDGFTATCANHQAWL--HLDNLGEDVREAL----SLLQQHREF 1218
Query: 1440 DKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDY 1499
+ ++ + L E L+ +H A + +LQ + +W L+ + R +L
Sbjct: 1219 GRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLAS 1278
Query: 1500 ANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVI 1559
L+++ +D+ EL +W+ E A E NI + +H+ E+ V +
Sbjct: 1279 LQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQ 1338
Query: 1560 NLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDF 1619
+G L+ C +E ++ +L+ L+ W+ L + ++G +L +A +Q++ ++D
Sbjct: 1339 QVGRELLSRRPC--GQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDA 1396
Query: 1620 EFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTF 1679
+ L + E L + +DL S+ L K+HQ LE E + L ++A + +S
Sbjct: 1397 KEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPA- 1455
Query: 1680 NVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQ 1739
I+++ +R +Q A +L+ + L QF + E SW+ E + S
Sbjct: 1456 ----ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
Query: 1740 DYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVE 1799
Y L G Q+L +KHK L+ E+ AH+ +Q VL L AA G + Q + Q E
Sbjct: 1512 SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSL---AASGHPQAQHIVEQCQE 1568
Query: 1800 ---HWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQS 1856
HW +L+ +AR L++++ + Q+ + E E W+ EK L D G AAT
Sbjct: 1569 LEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLR 1628
Query: 1857 LLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKA 1916
L+ KH+AL+ + A++ + ++ + + + + E+ + + E L E+ +L +
Sbjct: 1629 LINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQ-----ERLREQLRALQEL 1683
Query: 1917 IAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGN-GADLGDFLTLLAKQDTLDA 1975
A +LE EF +A+ ++ W+A ++ + K + G D L L K
Sbjct: 1684 AATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQH 1743
Query: 1976 SLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQ 2035
++ Q R+ L + L+ H+ + +R L W +L E + L + +
Sbjct: 1744 QVEMGSQ-RVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTE 1802
Query: 2036 LPLQKAEDL---FVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASL 2092
L+ DL + KA++L N N++ L + + H+ L
Sbjct: 1803 TTLRVHRDLLEVLTQVQEKATSLPN-------NVAR-----DLCGLEAQLRSHQGLEREL 1850
Query: 2093 ARAQADFKCLLELDQQIKAL-GVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEAR 2151
+ + LLE +++ L P + + + + W L +E+R +L++
Sbjct: 1851 VGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERA--- 1907
Query: 2152 QVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKR 2211
+ F + W R +E + +L A++ + E++A ++
Sbjct: 1908 -----RLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREK 1962
Query: 2212 QLTKIVDLGDNLEDALIL------DIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQ 2261
+ LG + AL+ +++ L Q DQ+YQ R Q L+ + Q
Sbjct: 1963 LWQQATQLG---QQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ 2015
Score = 357 bits (917), Expect = 6e-98
Identities = 471/2268 (20%), Positives = 900/2268 (39%), Gaps = 154/2268 (6%)
Query: 23 EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLG---KWIMEKVNILTDK 79
+IQ +++E+ R+ + E+ +L S + F ++ + ++ ++ L
Sbjct: 935 QIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPG 994
Query: 80 SYEDPTN-IQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRH 138
S ED + +Q +K LE V ++ ++E+ G++ + + +E L+
Sbjct: 995 SSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP-------GYAESQPLQGQVETLQG 1047
Query: 139 LWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHK 198
L + E ++ + Q ++QE +L W +A S E+ D + L +
Sbjct: 1048 LLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLR 1107
Query: 199 KFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQK 258
+ +D E+ + R+ +++ + A + PD + + + + L+ L QRQ+
Sbjct: 1108 EHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQ 1167
Query: 259 ALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSD 318
L LQ+F R+V + L ++ G+D+ + L H+ R L+ +
Sbjct: 1168 WLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGP 1227
Query: 319 KVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSD 378
+ + L A EKL S A ++E + + + W ++ + R +L A+ + D
Sbjct: 1228 RAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQD 1287
Query: 379 FDELSGWMNEKTAAINADELPTDVAGGEV-LLDRHQQHKHEIDSYDDRFQSADETGQDLV 437
EL WM EK + A P+ + L RH+ + E+ + ++ + G++L+
Sbjct: 1288 VAELMQWMEEK--GLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELL 1345
Query: 438 NANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEA 497
+ ++++ +++ L + W AL ER + +Q R + + + E
Sbjct: 1346 SRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEG 1405
Query: 498 FLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIR 557
L++ + G L S++ L ++H+ E K+ + A + E K +R
Sbjct: 1406 ALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLR 1465
Query: 558 DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQN-L 616
R + L+ A R L+ S+ L + S+ +W+ + Y + N
Sbjct: 1466 -----RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGA 1520
Query: 617 KSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEAT 676
+S +K + + E+ ++ Q++ + +G+ + GH + ++ + E+ W EL A
Sbjct: 1521 QSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERAC 1580
Query: 677 KQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAV 736
+ + L +A Q+ + +L+ W+E+ V+S DYG+ A + KH L+ +
Sbjct: 1581 EARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEEL 1640
Query: 737 AARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQ 796
A ++ L A P+ + R QE L + AL+E ATR ++L L L
Sbjct: 1641 AIYWSSMEELDQTAQTLTGPEVPEQQ--RVVQERLREQLRALQELAATRDRELEGTLRLH 1698
Query: 797 LICRDTEDEEAWIQETEPSAT-STYLGKDLIASKKLLNRHRVILENIASHEPRIQEITER 855
R+ ED + W+ + +A LG+D + L + + R+
Sbjct: 1699 EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLL 1758
Query: 856 GNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWI 915
++E GH A V R + L L R + L + DL E T +
Sbjct: 1759 AESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQV 1818
Query: 916 REKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRN------------QAN 963
+EK + N N D A L+ H+ +L ++ L QA+
Sbjct: 1819 QEKATSLPN-NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAH 1877
Query: 964 ACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKK---GDVLTLLSSINKDWWKVEAA 1020
A QQ+Q A + A QR M Q R + + D + + + +D E++
Sbjct: 1878 AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESS 1937
Query: 1021 D-----------HQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLD 1069
HQ + + R + L Q+ G T ++++ + R+L D
Sbjct: 1938 QEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPT---KEVQEELRALQD 1994
Query: 1070 RAEE-------RRRRLLQRYNEFLLAYEAGDMLEWIQEK----KAENTGVELDDVWELQK 1118
+ ++ ++ RL E L E G + E + + K G +++V +L +
Sbjct: 1995 QRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIR 2054
Query: 1119 KFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELN---SRWGSLQRLADEQ 1175
K + F K L + + + L E L T ++R L R ++ LA+ +
Sbjct: 2055 KHEVFLKVLTAQDKK--------EAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
Query: 1176 RQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPL 1235
L ++ + F + A ++ I+ Q L P DL +H+ FE ++
Sbjct: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAH 2166
Query: 1236 GDKVTILGETAER-LSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLF 1294
+ +T + + E L++SHP A E QR + L + WEDL+ R + L + + F F
Sbjct: 2167 EEVMTSVAKKGEALLAQSHPRAGEVSQRLQ-GLRKHWEDLRQAMALRGQELEDRRNFLEF 2225
Query: 1295 LSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEA---PTFQALEDF 1351
L + + WI ++ +L +DL L R +E R + + +++ D
Sbjct: 2226 LQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDL 2285
Query: 1352 SAELIDSGHHASPEIEKKLQAVKLERDDLEKAWE-------KRKKILDQCLELQMFQGNC 1404
S +L + PE +++ + R L W + ++ L+ LE+ +
Sbjct: 2286 SLQL----KNRDPE---EVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSREL 2338
Query: 1405 DQVESWMVARENSLRS-DDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIAD 1463
D V + +E +++ D L+S++ L++K ++L++ + + ++ LE L
Sbjct: 2339 DNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQR 2398
Query: 1464 EHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTA 1523
A + R Q V + W L+++ R L ++ L+EL ++ L
Sbjct: 2399 SPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLV-SAQRLRAQ 2457
Query: 1524 CDESYKDATNIQRKYL--KHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQ 1581
D S + ++ + + +HQ E+D ++ + + G L+ +A +++
Sbjct: 2458 MDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL--TAGHPFSSDIRQV 2515
Query: 1582 LEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLAS 1641
L L++ L + +L +A Q F +S+ E WL E LA + LA
Sbjct: 2516 LAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAP 2575
Query: 1642 AGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQEL 1701
LL KH++LE ++ + + L A L G + + + R +
Sbjct: 2576 MEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQ 2635
Query: 1702 AAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGE 1761
A +L+E L F QD + +W+ EK + V+ ++ D + L+K + + E
Sbjct: 2636 AGTRRHRLEELRQLQAFLQDSQEVAAWLREKNL-VALEEGLLDTAMLPAQLQKQQNFQAE 2694
Query: 1762 LVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEY 1821
L A Q + ++L E IQ RL + W +L++ ++ + KL+++ E
Sbjct: 2695 LDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEA 2754
Query: 1822 LQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQ 1881
L+ ++ EE E W+ G L LL L E V Q
Sbjct: 2755 LRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL-------EAAVDKKARQ 2807
Query: 1882 GEDILNK----VLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKA 1937
E +L + V + +++ + L ++ SL + + + LE +F A
Sbjct: 2808 AEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDA 2867
Query: 1938 DVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEIT-DLKDKLI 1996
D AW+ +K G L L + L++ + S E L + KL+
Sbjct: 2868 DEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSS--HEALTRVVLGTGYKLV 2925
Query: 1997 SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALN 2056
A H + + R L K L A A R+ LL++ Q+A+ E S L
Sbjct: 2926 QAGHFAAHEVAARVQQLEKAMAH-LRAEAARRRLLLQQ---AQEAQQFLTELLEAGSWLA 2981
Query: 2057 NWCEKME-ENLSEPVHCVS--LNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALG 2113
++ E++ L + ++D E F + R Q LLE +
Sbjct: 2982 ERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQ-QTAALLESRKN----- 3035
Query: 2114 VPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173
P SP + L + E + L++ EAR E Q +
Sbjct: 3036 -PESP----------KVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQ---------- 3074
Query: 2174 LETRAYFLDGSLLKETGTLESQ-----LEANKRKQKEIQAMKRQLTKI 2216
LE LD L + T ESQ LE K +++ A ++++ +
Sbjct: 3075 LERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSL 3122
Score = 347 bits (889), Expect = 1e-94
Identities = 408/2002 (20%), Positives = 797/2002 (39%), Gaps = 160/2002 (7%)
Query: 207 LVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANL 266
++ +EGR + + A+ +E + + +Q EV W+RL ++K +++ +
Sbjct: 441 ILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAV 500
Query: 267 QRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAK 326
++V A ++E + S G+ L L H LE ++ V L +
Sbjct: 501 LSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQ 560
Query: 327 AEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWM 386
+L S + +Q L + + AL +R L+ T F + +E W+
Sbjct: 561 TAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWL 620
Query: 387 NEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDE 446
E + L D++ L +H+ + E+ + G+DL +
Sbjct: 621 KECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPD 680
Query: 447 VREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGN 506
E+ E + W L R + + L ++ D+ + SW+ + + LE G
Sbjct: 681 PGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQ 740
Query: 507 SLGSAEALLQKHEDFE---EAFTAQ----EEK---------IITVD-------------- 536
+AE LL++H E AF A+ EE+ + TV+
Sbjct: 741 DQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPG 800
Query: 537 ---------------KTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKES 581
K A D +D I +D L ++LR A RR L+E+
Sbjct: 801 PWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEA 860
Query: 582 LLLQKLYEDSDDLKNWINKK----KKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQL 637
+ L +L+ W+ K+ +++ D ++ L K + F LAV K
Sbjct: 861 MALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQL-----KYENFLTALAVGKGLW 915
Query: 638 ENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAE 697
+ + +++ + S + + E++ W +L ++K QL + + F
Sbjct: 916 AEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECG 975
Query: 698 DLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIG 757
Q L DV Q+ + G ++ L + + +V L + EE G
Sbjct: 976 PTQVQLRDVLLQLEALQPGSS----EDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPG 1031
Query: 758 HPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSAT 817
+ +S+ ++ + E+L + ++E +A R ++ + Q ++++ W + +
Sbjct: 1032 YAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLR 1091
Query: 818 STYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSL 877
S + D+ ++++LL H+ +LE I + R+Q++ + M +++V + ++ L
Sbjct: 1092 SKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVL 1151
Query: 878 NQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGAL 937
Q + L+ +RQ L+ ++ Q++ ++ + + N G D A +L
Sbjct: 1152 GQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSL 1211
Query: 938 LKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVT 997
L++H F L++ G +ALR Q Q P EQ L QA+ R
Sbjct: 1212 LQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ-HPAAHTVREQ----LQSIQAQWTRLQG 1266
Query: 998 MKKGDVLTLLSSINKDWWKVEAA------DHQGIVPA-----------VYVRRLAHDEFP 1040
+ LL+S+ WK + A + +G++ A ++R E
Sbjct: 1267 RSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESE 1326
Query: 1041 MLPQRRREEPGNITQR---------QEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEA 1091
+L RR E R QE I+ + + L + E R++ +R +E A +
Sbjct: 1327 LLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQ 1386
Query: 1092 GDMLEWIQEKK-----------AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKV 1140
+L +Q+ K + TG +L LQK+ + + + T ++ + +
Sbjct: 1387 EQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASM 1446
Query: 1141 ADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIE 1200
A + + E + + L G LA QL S H+ + ++
Sbjct: 1447 AHGMAASPAILEETQKHLRRLELLQG---HLAIRGLQLQASVE----LHQFCHLSNMELS 1499
Query: 1201 KKCQALSAADPGS---DLFSVQALQRRHEGFERDL-VPLGDKVTILGETAERLSESHPDA 1256
+ + P S L Q+L R+H+ + ++ G +L + HP A
Sbjct: 1500 WVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQA 1559
Query: 1257 TEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQE 1316
+ + Q EL W +L+ + R + L +A F + +L+ W+ +VSS++
Sbjct: 1560 -QHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRD 1618
Query: 1317 LAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLE 1376
D L+ +HQ + ++ + + L+ + L PE+ ++ + V+
Sbjct: 1619 YGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTL------TGPEVPEQQRVVQER 1672
Query: 1377 -RDDLEKAWE---KRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEA- 1431
R+ L E R + L+ L L F + ++ W+ +++ + + + D A
Sbjct: 1673 LREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHAL 1732
Query: 1432 -LMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLI 1490
L K + ++ AESL+ H A + R Q + W L
Sbjct: 1733 HLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQ 1792
Query: 1491 DERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDG 1550
L D + +RDL E+ + E + + +D ++ + HQ E+ G
Sbjct: 1793 ARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVG 1852
Query: 1551 RSEQVHGVINLGNSLIECSACDGNE-EAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQ 1609
Q+ ++ + + C G + A++++ + + + W L R + +L A
Sbjct: 1853 TERQLQELLETAGRVQK--LCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
Query: 1610 QRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTL 1669
RF T++RD+ W + L +++ +++ +S L HQ L E+ ARE + L
Sbjct: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQL 1970
Query: 1670 AEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWI 1729
+ L + ++ ++ + + V + A E+L+ F ++ E +
Sbjct: 1971 GQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEIL 2030
Query: 1730 EEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEE 1789
+ + + + G ++ V+ L++KH+ L A + + + E+LK + +
Sbjct: 2031 AAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQD---KKEAALRERLK---TLRRPR 2084
Query: 1790 IQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEE----AWINEKNALAVRG 1845
++ RL ++ ++KELA++RG L SL F Q A + E AW + G
Sbjct: 2085 VRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPG 2144
Query: 1846 DCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEA 1905
D D L L+KH+A E + HE + +V +GE +L Q + E+S +++
Sbjct: 2145 DLRDKLKP----LLKHQAFEAEVQAHEEVMTSVAKKGEALL---AQSHPRAGEVSQRLQG 2197
Query: 1906 LNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLT 1965
L + L +A+A +LED F EF + D+ EAWI +KE + G DL L
Sbjct: 2198 LRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQ 2257
Query: 1966 LLAKQDTL--DASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEA 2023
L + +++ + + I+DL +L + + K I +R + L RW
Sbjct: 2258 LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRW------ 2311
Query: 2024 SAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEEN--LSEPVHC-VSLNEIRQ 2080
A LL Q L+ A ++ V + L+N ++++E L + + C L +++
Sbjct: 2312 -ASFHGNLLRYQQQLEGALEIHV----LSRELDNVTKRIQEKEALIQALDCGKDLESVQR 2366
Query: 2081 LQKDHEDFLASLARAQADFKCL 2102
L + HE+ + QA + L
Sbjct: 2367 LLRKHEELEREVHPIQAQVESL 2388
Score = 328 bits (840), Expect = 5e-89
Identities = 424/2113 (20%), Positives = 812/2113 (38%), Gaps = 146/2113 (6%)
Query: 134 EELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERT 193
EE+ W LL+ + Q+ +QE + + + A S G+
Sbjct: 474 EEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEV 533
Query: 194 EVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLA 253
L ++ + + ++ A V + Q E + ++Q+K + + L L
Sbjct: 534 VELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALV 593
Query: 254 LQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNL 313
R+ L F R+ E W+KE + + G+DL G HK LE +
Sbjct: 594 RARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEV 653
Query: 314 AVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYH 373
+L + L+ P P E E + W+ ++ R +LQ
Sbjct: 654 HRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVL 713
Query: 374 RFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETG 433
++ +D E + W+ E+ +++ D A E LL RH + + + ++ + +E G
Sbjct: 714 QYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQG 773
Query: 434 Q------DLVNANHEAS---------------------------------------DEVR 448
+ L N S + +
Sbjct: 774 RAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTIL 833
Query: 449 EKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSL 508
+ + L ++ +L L R + E+ + F ++ W+ +Q L+ +
Sbjct: 834 QTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQR--VQPQA 891
Query: 509 GSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDAL- 567
+ E + K+E+F A + V +A +L +S I+ ++ L R L
Sbjct: 892 DTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLE 951
Query: 568 ---REKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQ 624
REKA ++ LQ+ L++ + + + L L Q
Sbjct: 952 ALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHAL-------Q 1004
Query: 625 VFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLH 684
+ +K+ V + ++ +Q ++ E G+ S + ++ + L +++ E Q+ +
Sbjct: 1005 LAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQA 1064
Query: 685 EANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVD 744
E + F ++ L W E V+ Q+ S++ +A Q LR+H L + Q+++
Sbjct: 1065 ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQ 1124
Query: 745 ILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTED 804
L + + PDS+++ L + + LK R++ L + L LQ R+ +
Sbjct: 1125 QLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDG 1184
Query: 805 EEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGH 864
A + LG+D+ + LL +HR +++ PR + + G K+V+ H
Sbjct: 1185 FTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQH 1244
Query: 865 FAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDN 924
AA V +++S+ L+ R+ +R+ L A++Q Q++ D+ E W+ EK + +
Sbjct: 1245 PAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAH 1304
Query: 925 TNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMA 984
GA LK+HEA +L + ++AL+ ++ E + + R+
Sbjct: 1305 EPSGARRNIL-QTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDI--QTRLQG 1361
Query: 985 LYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQ--GIVPAVYVRRLAHDEFPML 1042
L R++T ++GD L + +++ A Q + A+ D L
Sbjct: 1362 LRSKWEALNRKMT-ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQD----L 1416
Query: 1043 PQRRREEPGNITQRQEQIENQYRSL--------------------LDRAEERRRRL---- 1078
+R + +R +Q+E++ R+L L+ ++ RRL
Sbjct: 1417 RSSQR-----LQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQ 1471
Query: 1079 ---------LQRYNEFLLAYEAGDM-LEWIQEKKAENTGVE----LDDVWELQKKFDEFQ 1124
LQ E +M L W+ E + L+ L +K E Q
Sbjct: 1472 GHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQ 1531
Query: 1125 KDLNTNEPRLRDINKVADDLLFEGLLTPEGAQI---RQELNSRWGSLQRLADEQRQLLGS 1181
++ ++ +++ + L G P+ I QEL W L+R + + Q L
Sbjct: 1532 VEVKAHQGQVQRVLSSGRSLAASG--HPQAQHIVEQCQELEGHWAELERACEARAQCLQQ 1589
Query: 1182 AHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTI 1241
A + + + + + +E+K +S+ D G D + L +H+ + +L +
Sbjct: 1590 AVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEE 1649
Query: 1242 LGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDL 1301
L +TA+ L + P+ E + + L E LQ R L + + FL +A DL
Sbjct: 1650 LDQTAQTL--TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDL 1707
Query: 1302 QNWISSIGGMVSSQE-LAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGH 1360
Q W++S E L ED L + + + +E + A + L++ GH
Sbjct: 1708 QGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGH 1767
Query: 1361 HASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRS 1420
A P + ++ Q ++ +L + + R L + +V + + + SL +
Sbjct: 1768 SAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPN 1827
Query: 1421 DDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFA---ESLIADEHYAKEEIATRLQR 1477
+ L LEA ++ L++ + E ++ +L A + L + R Q
Sbjct: 1828 NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQ--AHAVQQRQQA 1885
Query: 1478 VLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEM-LPTACDESYKDATNIQR 1536
V W L+ ++ R +L L +F + + W + + +ES ++ ++
Sbjct: 1886 VTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL 1945
Query: 1537 KYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERT 1596
K HQ E++ R + LG + + E ++E+L L++ D + +
Sbjct: 1946 KLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE--VQEELRALQDQRDQVYQTW 2003
Query: 1597 NDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREM 1656
K ++L ++Q F E L+ E L + L++KH++ + +
Sbjct: 2004 ARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVL 2063
Query: 1657 LAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF 1716
A++ K L E L T ++ + + +R + V+ELA + L + +
Sbjct: 2064 TAQD---KKEAALRERL---KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMA 2117
Query: 1717 QFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMA 1776
F Q E WI+ ++ DL+ L KH+ E E+ AHE + +V
Sbjct: 2118 SFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKG 2177
Query: 1777 EKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWIN 1836
E L ++ E+ RL +HWE L++ RG +LE+ +L+F+Q + EAWI
Sbjct: 2178 EALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQ 2237
Query: 1837 EKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVL--QEES 1894
EK GD G L L + + A V + C + L+ L ++
Sbjct: 2238 EKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSA--GDTVGDACIRSISDLSLQLKNRDPE 2295
Query: 1895 QNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTN 1954
+ K I + LN + S + ++ QLE + + D V I +KE ++
Sbjct: 2296 EVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQAL 2355
Query: 1955 GNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALL 2014
G DL LL K + L+ + Q + + + +L + + R +
Sbjct: 2356 DCGKDLESVQRLLRKHEELEREVHPIQAQ-VESLEREVGRLCQRSPEAAHGLRHRQQEVA 2414
Query: 2015 KRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVS 2074
+ W Q L + A R++ L+ QK + + E A L + S PV
Sbjct: 2415 ESWWQ-LRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRS-PV---- 2468
Query: 2075 LNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHL 2134
E R++ ++H++ A L QQ+ G P S + LE+ L
Sbjct: 2469 --EARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSL 2526
Query: 2135 SDIIEEREQELQK 2147
+E + +LQ+
Sbjct: 2527 EGAWQEHQLQLQQ 2539
Score = 290 bits (741), Expect = 2e-77
Identities = 465/2348 (19%), Positives = 902/2348 (38%), Gaps = 245/2348 (10%)
Query: 17 VLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDL---------GK 67
V EE+ R Q +L Q +++VA+ L ++ ++L G+
Sbjct: 469 VARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQ 528
Query: 68 WIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSEL-EKTREERFTMGHSAH 126
+ E V +L Q+H LEA+V +S L ++T E ++G S
Sbjct: 529 QLAEVVELL---------------QRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSV- 572
Query: 127 EETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVEL 186
E +A L L L+ L + L + L+ ++++ C + W+ + + L
Sbjct: 573 EVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAAL 632
Query: 187 GEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAW 246
G D + +K + + E+ + V++ + + + P P + V W
Sbjct: 633 GRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGW 692
Query: 247 ERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSH 306
+ L+ + R L A + ++ D EA W++E+ L G+D A+E L H
Sbjct: 693 QLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRH 752
Query: 307 KGLERNLAVMSDKVKEL-------CAKAEKLTLS---------------------HPS-- 336
LER L + +++ L A+A T++ HP
Sbjct: 753 VRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPG 812
Query: 337 ---------------DAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDE 381
D I + ++ L +E +RALA R +L+ F S E
Sbjct: 813 DAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGE 872
Query: 382 LSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANH 441
L W+ ++T + + D EV+ +++ + + + + L
Sbjct: 873 LQLWLEKQTVLLQRVQPQADTL--EVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYP 930
Query: 442 EASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLEN 501
S +++ + E L W L L E+ Q ++ F ++ + ++ L+
Sbjct: 931 GNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQ--VQLRDVLLQL 988
Query: 502 EDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLL 561
E L GS+E + ++ E ++ + K+ + +S+ ++ + L
Sbjct: 989 EAL--QPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQ 1046
Query: 562 ARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINK-KKKLADDEDYKDIQNLKSRV 620
++E+ A R R E+ Q ++S L W + +L E D+ + + +
Sbjct: 1047 GLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLL 1106
Query: 621 QKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKG 680
++ Q +E+ + + +L+ + Q M S V L + +EL +Q+
Sbjct: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ 1166
Query: 681 TQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQ 740
L E + +F + + + + ++ G+ + E + L++H ++
Sbjct: 1167 QWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLG 1226
Query: 741 DQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICR 800
+ + L + HP + +R + +S+ ++ L+ R+++LL L LQ +
Sbjct: 1227 PRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQ 1286
Query: 801 DTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEP----------RIQ 850
D + W++E K L+A+ + R IL+ + HE ++
Sbjct: 1287 DVAELMQWMEE-----------KGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVE 1335
Query: 851 EITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHE 910
+ + G +++ ED+ +R++ L E+L + R ++L+ Q +Q L L +
Sbjct: 1336 ALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQD 1395
Query: 911 AETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANAC----- 965
A+ + + E + ++ G D ++ L K+H+ + + M AL + A+
Sbjct: 1396 AKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPA 1455
Query: 966 ----QQQQAAPVEGVAGE--------QRVMALYDFQARSPREVT-----MKKGDVLTLLS 1008
Q+ +E + G Q + L+ F S E++ M G +
Sbjct: 1456 ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTE 1515
Query: 1009 SIN--------KDWWKVEAADHQGIVPAVYV--RRLAHDEFPMLPQRRREEPGNITQRQE 1058
+N +VE HQG V V R LA P + +I ++ +
Sbjct: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHP--------QAQHIVEQCQ 1567
Query: 1059 QIENQYRSLLDRAEERRRRLLQR---YNEFLLAYEAGDMLEWIQEKK----AENTGVELD 1111
++E + L+RA E R + LQ+ + ++ L + ++ W++EK+ + + G +
Sbjct: 1568 ELEGHWAE-LERACEARAQCLQQAVTFQQYFL--DVSELEGWVEEKRPLVSSRDYGRDEA 1624
Query: 1112 DVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE-LNSRWGSLQR 1170
L K Q++L + ++++ A L G PE ++ QE L + +LQ
Sbjct: 1625 ATLRLINKHQALQEELAIYWSSMEELDQTAQTL--TGPEVPEQQRVVQERLREQLRALQE 1682
Query: 1171 LADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADP-GSDLFSVQALQRRHEGFE 1229
LA + + L + F REA+D + + + QA + G D L + F+
Sbjct: 1683 LAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQ 1742
Query: 1230 RDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQ 1289
+ +V AE L E A +++++ +L AW +L T+ R +L + +
Sbjct: 1743 HQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTE 1802
Query: 1290 KFYLFLSKARDLQNWISSIGGMVSS--QELAEDLTGIEILLERHQEHRADMEAEAPTFQA 1347
L RDL ++ + +S +A DL G+E L HQ ++ Q
Sbjct: 1803 ---TTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQE 1859
Query: 1348 LEDFSAEL--IDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCD 1405
L + + + + G A ++++ QAV L++ E+R+ L++ L F+
Sbjct: 1860 LLETAGRVQKLCPGPQAH-AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVR 1918
Query: 1406 QVESWMVARENSLRSDDKSSLDSLEAL-MKKRDDLDKAITAQEGKITDLEHFAESLIADE 1464
SW L+ ++ S S L + L + A+E + +
Sbjct: 1919 DYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAA 1978
Query: 1465 HYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWIS----EML 1520
+E+ L+ + D+ + ++ +L + F R+ LEE ++ +
Sbjct: 1979 GTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLK 2038
Query: 1521 PTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKE 1580
+A S ++ + R KH+ F L +A D E A++E
Sbjct: 2039 TSALGSSVEEVEQLIR---KHEVF--------------------LKVLTAQDKKEAALRE 2075
Query: 1581 QLEQL-----KEHWDHLLER-------TNDKGKKLNEASRQQRFNTSIRDFEFWLSEAET 1628
+L+ L ++ LL+R +G L+ + F + E W+
Sbjct: 2076 RLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQ 2135
Query: 1629 LLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688
L DL L KHQ E E+ A E+ + + E LL+ ++ ++
Sbjct: 2136 QLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRL 2195
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748
+ K + ++++ A ++L++ +F Q +D E+WI+EK ++++ D G+DL+
Sbjct: 2196 QGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHC 2255
Query: 1749 QNLLKKHKRLEGELVAH---EPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLK 1805
L ++ + G + I+++ D++ +LK++ + I R +Q W
Sbjct: 2256 LQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFH 2315
Query: 1806 ELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALE 1865
+LE +LE + + I EK AL DCG L + Q LL KHE LE
Sbjct: 2316 GNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELE 2375
Query: 1866 NDFAVH---------ETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKA 1916
+ VH E V +C + + + + + + E ++ + +K A
Sbjct: 2376 RE--VHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA 2433
Query: 1917 I-AAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDA 1975
+ A KLQ QE A + A + T+ + +L + A
Sbjct: 2434 LHQAQKLQA----MLQELLVSAQRLRA-------QMDTSPAPRSPVEARRMLEEHQECKA 2482
Query: 1976 SLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQ 2035
L S+ + + +L++A H S I + A L + L A H Q
Sbjct: 2483 ELDSW-TDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEH-------Q 2534
Query: 2036 LPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARA 2095
L LQ+A +L + F + W E++L+ L + L H+ L
Sbjct: 2535 LQLQQALELQL-FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQ 2593
Query: 2096 QADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKN 2155
L + + G P + + + + L R L EE RQ+
Sbjct: 2594 AGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRL--EELRQL-- 2649
Query: 2156 FEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTK 2215
Q F Q++ W+ E L+ LL +T L +QL+ + Q E+ A Q +
Sbjct: 2650 ----QAFLQDSQEVAAWLREKNLVALEEGLL-DTAMLPAQLQKQQNFQAELDASMHQQQE 2704
Query: 2216 IVDLGDNL 2223
+ G L
Sbjct: 2705 LQREGQRL 2712
Score = 269 bits (687), Expect = 3e-71
Identities = 443/2266 (19%), Positives = 865/2266 (38%), Gaps = 203/2266 (8%)
Query: 137 RHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVL 196
R L +LL+L + +LL+ QY Q AD+L WI +K+ + + + L
Sbjct: 257 RRLTKILLQL---QETELLQT----QYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQL 309
Query: 197 HKKFEDFQVE----LVAKEG-------RVVEVNQYANECAEENHPDLPLIQSKQNEVNAA 245
F F+ + + + G R+ Q N H L L + Q
Sbjct: 310 LAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLE 369
Query: 246 W-ERLRGLAL-QRQKALSNAANL-QRFKRDVTEAIQWIKEKEPVL-TSEDYGKDLVASEG 301
W E R AL QR L L +RF+ ++K+ E VL + L E
Sbjct: 370 WAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEA 429
Query: 302 LFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATS 361
LE + + + L A+ L + +E++ W+ +
Sbjct: 430 AVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQG 489
Query: 362 RYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDS 421
+ +++ + + S + E + +A LL RH + ++ +
Sbjct: 490 QRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSA 549
Query: 422 YDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLF 481
+ + +L ++ + + ++ K L +L+ L R EQ L F
Sbjct: 550 HGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEF 609
Query: 482 YRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATK 541
R+ E+ ++W+ + N LG L LQKH+ E + + + +
Sbjct: 610 LRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRD 669
Query: 542 LIG----DDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNW 597
L E +A++ G L+ + R L+ +LL+ + + D+ + +W
Sbjct: 670 LSARRPPTQPDPGERAEAVQGGW----QLLQTRVVGRGARLQTALLVLQYFADAAEAASW 725
Query: 598 INKKK----KLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLEN-------------- 639
+ +++ + + +D + L R + + + A +LE
Sbjct: 726 LRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTV 785
Query: 640 ---IQKTGQEMIEGGHYAS-------------------------DNVTTRLSEVASLWEE 671
+ G+ + G ++ + + ++ +E
Sbjct: 786 NSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYES 845
Query: 672 LLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGL 731
L + + +L EA F ++ +LQ WLE + EV +L+
Sbjct: 846 LRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVM-QLKYENF 904
Query: 732 LESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLD 791
L +A+A + ++ A + +S I+ +QE L R+ L+ A +++K +
Sbjct: 905 L-TALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLE---ALKREKAVQ 960
Query: 792 LLHLQLICRDTEDEEAWIQETEPS------------ATSTYLGKDLIASKKLLNRHRVIL 839
L H +C +++QE P+ A +D + +L + ++L
Sbjct: 961 LAHSVEVC-------SFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVL 1013
Query: 840 ENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLR---ARAARRQNDLE 896
E R+ + K+ E G+ ++ + +V++L ++ ++ A+ ARRQ + +
Sbjct: 1014 ER------RVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQ 1067
Query: 897 ANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMK 956
A Q +L + + W + + + D +A LL++H+ L +++ + + ++
Sbjct: 1068 AR---QSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQ 1124
Query: 957 ALRNQANACQQQQAAPVEGVAGEQRVMALYDFQAR---SPREVTMKKGDVLTLLSSINKD 1013
L Q+ + V RV+ + + R+ +++G L D
Sbjct: 1125 QLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR-EVD 1183
Query: 1014 WWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRR-------------------------E 1048
+ A+HQ + + + +L Q R +
Sbjct: 1184 GFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
Query: 1049 EPGNITQRQ--EQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEK---KA 1103
P T R+ + I+ Q+ L R+E+RRR+LL + ++++W++EK A
Sbjct: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAA 1303
Query: 1104 ENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR-QELN 1162
++ + K+ + + +L + + +V +LL E Q R Q L
Sbjct: 1304 HEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLR 1363
Query: 1163 SRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQ 1222
S+W +L R E+ L A E R+ D KEQ+E+ AL +++ G DL S Q LQ
Sbjct: 1364 SKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQ 1423
Query: 1223 RRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRK 1282
+RH+ E + L K+ L A ++ S P E+ Q+ L E LQG R
Sbjct: 1424 KRHQQLESESRTLAAKMAALASMAHGMAAS-PAILEETQKHLRRL----ELLQGHLAIRG 1478
Query: 1283 ESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEA 1342
L + + + F + +W++ S E L G + L +H+E + +++A
Sbjct: 1479 LQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQ 1538
Query: 1343 PTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQG 1402
Q + L SGH + I ++ Q ++ +LE+A E R + L Q + Q +
Sbjct: 1539 GQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFL 1598
Query: 1403 NCDQVESWMVARENSLRSDDKSSLDSLE-ALMKKRDDLDKAITAQEGKITDLEHFAESLI 1461
+ ++E W+ + + S D ++ L+ K L + + + +L+ A++L
Sbjct: 1599 DVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT 1658
Query: 1462 ADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLP 1521
E ++ + +R+ ++ +AL+ +L L +F R+ E+L+ W++
Sbjct: 1659 GPEVPEQQRVVQ--ERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQ 1716
Query: 1522 TA-----CDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE 1576
A E + A ++ K+ K F H+V+ S++V L SL+E G
Sbjct: 1717 AAKGGESLGEDPEHALHLCTKFAK---FQHQVEMGSQRVAACRLLAESLLERGHSAG--P 1771
Query: 1577 AMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQA 1636
++++ + L+ W L E T +G L + R + + + + E T L + A
Sbjct: 1772 MVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLP-NNVA 1830
Query: 1637 RDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDL--LSSGTFNVDQIVKKKDNVNKR 1694
RDL L+ HQ LERE++ E L++L A + L G + +++ V +
Sbjct: 1831 RDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGP-QAHAVQQRQQAVTQA 1889
Query: 1695 FLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKK 1754
+ +Q +L+ A L +F + D SW + ++ ++ L
Sbjct: 1890 WAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSA 1949
Query: 1755 HKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLK 1814
H+ L EL A E Q + ++ A +E+Q E+L+ L R
Sbjct: 1950 HQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ----------EELRALQDQRDQV 1999
Query: 1815 LEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETR 1874
+ + +Q ++E+ ++ E L + T +L E +E HE
Sbjct: 2000 YQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVF 2059
Query: 1875 VQNVCAQGEDILNKVLQEE---SQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQ 1931
++ + AQ D L+E + + ++ L ++ + + + L
Sbjct: 2060 LKVLTAQ--DKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMA 2117
Query: 1932 EFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDL 1991
F A E WI LK DL D L L K +A +Q+ +E + +
Sbjct: 2118 SFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA-HEEVMTSVAKK 2176
Query: 1992 KDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHK 2051
+ L++ H ++ + +R L K WE L +A A+ Q+L +++ F+EF +
Sbjct: 2177 GEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRR--------NFLEFLQR 2228
Query: 2052 ASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLAR---AQADFKCLLELDQQ 2108
W ++ E ++ L QL++ +F + A A + + +L Q
Sbjct: 2229 VDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQ 2288
Query: 2109 IKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNAST 2168
+K L W + +Q+L+ V + E+ N +
Sbjct: 2289 LKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSREL-----DNVTK 2343
Query: 2169 FLQWILETRAYFLD-GSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDAL 2227
+Q E LD G L+ L + E +R+ IQA L + V
Sbjct: 2344 RIQ-EKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEA 2402
Query: 2228 ILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETL 2273
+++ +A+ W QL + + L+ QA+ ++ + +E L
Sbjct: 2403 AHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELL 2448
Score = 241 bits (614), Expect = 8e-63
Identities = 215/995 (21%), Positives = 421/995 (42%), Gaps = 22/995 (2%)
Query: 8 TVVESSGPKVLETAEEIQERRQEVLTRYQ----SFKERVAERGQKLEDSYHLQVFKRDAD 63
++ S+G ++L ++VL + S + E +L+ + LQ+F +
Sbjct: 2492 SLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVE 2551
Query: 64 DLGKWIMEKVNILTDKSYEDP-TNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMG 122
+ +W+ K + L + DP ++ KH+ LE +++ ++ +S LE T G
Sbjct: 2552 KMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGG 2611
Query: 123 HSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIAT 182
H + + + + L + +L + Q ++Q+ ++ W+ +K +A
Sbjct: 2612 HPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVAL 2671
Query: 183 SVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEV 242
L + L K+ ++FQ EL A + E+ + + HP IQ + E+
Sbjct: 2672 EEGLLDTAMLPAQLQKQ-QNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEEL 2730
Query: 243 NAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGL 302
A W L+ + ++ L A R +R + E W++ E L + G+ L L
Sbjct: 2731 GALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGEL 2790
Query: 303 FHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSR 362
+ + LE + + + + L +A+ A ++E L+ ++ +R R
Sbjct: 2791 LGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQER 2850
Query: 363 YEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSY 422
L+A +F D DE W+ EK A + ++ L ++HQ + E+ S+
Sbjct: 2851 RTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSH 2910
Query: 423 DDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFY 482
+ + TG LV A H A+ EV +++ L+ L R +Q + F
Sbjct: 2911 EALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFL 2970
Query: 483 RDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKL 542
+ + SW++ + L++ED+G+S + +ALL++ E + A +I + +TA L
Sbjct: 2971 TELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALL 3030
Query: 543 IGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKK 602
+ +S + A + L +A R L+E L L +L ++ L W+ K
Sbjct: 3031 ESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKA 3090
Query: 603 KLADDEDY-KDIQNLKSRVQKQQVFEKEL-AVNKTQLENIQKTGQEMIEGGHYASDNVTT 660
A+ +DY +D++ +K +K F KE+ ++ + ++ ++K + G ++
Sbjct: 3091 ATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQA 3150
Query: 661 RLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLA 720
+ S + + WE L +A K + L A++ F+ A +LQ +++ + ED G L+
Sbjct: 3151 QRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLS 3210
Query: 721 EVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKE 780
V+ ++H LE + A + +V L A ++ HP + A+ + + L+
Sbjct: 3211 SVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQL-HPAAPGGLAKVQE---AWATLQA 3266
Query: 781 PLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILE 840
R + L ++ AW QE + A+S L +D+ +++LL +H + +
Sbjct: 3267 KAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQ 3326
Query: 841 NIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQ 900
I + Q++ + G ++V+ HF + +V ++ L ++ L A R +
Sbjct: 3327 EIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWG 3386
Query: 901 FQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHE----AFLLDLNSFGDSMK 956
Q+ L +AE W+ E ++ +YG LL +H+ F K
Sbjct: 3387 LQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQK 3446
Query: 957 ALRNQANACQQQQAAPVEGVAGEQRVMALYDFQAR 991
Q Q Q+ P G AG +L FQ R
Sbjct: 3447 TEMEQELLLQPQELKP--GRAGS----SLTSFQWR 3475
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 495 bits (1274), Expect = e-139
Identities = 353/1389 (25%), Positives = 641/1389 (46%), Gaps = 42/1389 (3%)
Query: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKS 80
+E+I+ER + ++ + ++ A R ++LE++ L F+ DADD+ W+++ + I++
Sbjct: 699 SEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 758
Query: 81 Y-EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHL 139
D + Q +KH+ + E+ + L + + H+ + + + +
Sbjct: 759 VGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHE-QASALPQEHAESPDVRGRLSGIEER 817
Query: 140 WDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKK 199
+ + ELT + L L + E WI +KE ++++ E E EV+ +
Sbjct: 818 YKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHR 877
Query: 200 FEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKA 259
FE + E+ + RV VNQ A + HP I+++Q+++N W + R L +++ A
Sbjct: 878 FESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDA 937
Query: 260 LSNAANLQRFKRDVTEAIQWIKEKEPVLTS-EDYGKDLVASEGLFHSHKGLERNLAVMSD 318
L +A ++Q + + E WI+EK V+ S +D G DL L G+ER+L +
Sbjct: 938 LLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEA 997
Query: 319 KVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSD 378
K+ +L +AEKL HP A I ++ WE ++ +R L +F D
Sbjct: 998 KLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRD 1057
Query: 379 FDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN 438
D+ W++ AI ++++P + E LL +H+ K+EID+Y++ +Q + G+ +
Sbjct: 1058 LDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQ 1117
Query: 439 ANHEASDE-VREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEA 497
+A +R++++ LD W L ++W+ R Q + F RD++Q +++++ QE
Sbjct: 1118 GQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEY 1177
Query: 498 FLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIR 557
L + ++ +L AEA ++K EDF A EEKI V +T +L+ D + +S+ I+
Sbjct: 1178 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1237
Query: 558 DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLK 617
D + R RE A+ LK++ LQK +D +L WIN+K A D Y + +NL
Sbjct: 1238 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1297
Query: 618 SRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATK 677
S+ K Q F ELA NK L+ I+K G ++I V +L+ + +WE L T+
Sbjct: 1298 SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ 1357
Query: 678 QKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVA 737
K +L +AN+ F + DL +WL +E Q+ S+DYGK L V L+K +LE+ +
Sbjct: 1358 TKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQME 1417
Query: 738 ARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQL 797
R+ +++ L A + G + ++ +++ ++ +F L EPL RK LL +
Sbjct: 1418 VRKKEIEELQSQAQALSQEG-KSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQ 1476
Query: 798 ICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGN 857
RD EDE W+ E P ATST G +L + L+ +++ + + I H+PRI +I ER
Sbjct: 1477 FNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQ 1536
Query: 858 KMV-EEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIR 916
+V + +AE + R+ L Q L +R LE + QQY D EAE W+
Sbjct: 1537 NIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMS 1596
Query: 917 EKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGV 976
E+E + + DE++A ++LKKH+ + + +++ L + A E +
Sbjct: 1597 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1656
Query: 977 AGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEA-ADHQGIVPAVYVRRLA 1035
+ Q + + E K D L +N++ +E + +V +
Sbjct: 1657 SMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQD 1716
Query: 1036 HDEFPMLPQRRRE---EPGNITQR--------------------------QEQIENQYRS 1066
++ ML +R RE + GNI Q ++ + +
Sbjct: 1717 YEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWAD 1776
Query: 1067 LLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK---AENTGVELDDVWELQKKFDEF 1123
LL+ + R + L Y ++A ++ IQ+K E G + + V LQ+ F
Sbjct: 1777 LLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTF 1836
Query: 1124 QKDLNTNEPRLRDINKVADDL--LFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGS 1181
+ D+ ++R + + A L + G + + E+ W SL + +R L
Sbjct: 1837 EHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVD 1896
Query: 1182 AHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTI 1241
F D +E + + A + D+ SV+ L H+G + ++ D T
Sbjct: 1897 TGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTT 1956
Query: 1242 LGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDL 1301
E + L A+E+++ + ++L E +++ + +DR E L + + F A
Sbjct: 1957 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2016
Query: 1302 QNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSA-ELIDSGH 1360
+ W+ +SS+E+ + + +E L++RH+ F ALE + EL++
Sbjct: 2017 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRR 2076
Query: 1361 HASPEIEKK 1369
E K+
Sbjct: 2077 QQEEEERKR 2085
Score = 438 bits (1126), Expect = e-122
Identities = 380/1780 (21%), Positives = 793/1780 (44%), Gaps = 83/1780 (4%)
Query: 49 LEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPT-----NIQG-----------KYQ 92
+E ++ ++ A DL +WI + + IL ++ + + +Q K+
Sbjct: 285 IETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFT 344
Query: 93 KHQSLEAEVQT-KSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTL--- 148
+ +LE + T +S++ + +K R S + +E+ H +L L L
Sbjct: 345 EKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQ 404
Query: 149 EKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELV 208
EK +QL R + ++E W+ + + + + G D E KK E + ++
Sbjct: 405 EKLEQLARRFDRKAAMRET-----WLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIA 459
Query: 209 AKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQR 268
A E RV V A E EN+ D+ I ++++ V WE L L R++ L LQ+
Sbjct: 460 AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQK 519
Query: 269 FKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAE 328
+++ + W+ E + ++ S+DYGK L+ E L H +E ++ + +++V+ + A A+
Sbjct: 520 IFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQ 579
Query: 329 KLTLS----HPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSG 384
K P D I++ + ++ + LA R +L+ + +F + E G
Sbjct: 580 KFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEG 639
Query: 385 WMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEAS 444
W+ EK +++D+ D+ LL +H+ + E+ F+ A + G+D++ H S
Sbjct: 640 WIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGS 699
Query: 445 DEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDL 504
+++RE++ + W L +L R ++ E+ H F D++ +D+WM + + D+
Sbjct: 700 EKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDV 759
Query: 505 GNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARR 564
G+ S ++L++KH+D E + T+ + A+ L +H +S +++ G+ R
Sbjct: 760 GHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERY 818
Query: 565 DALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADD----EDYKDIQNLKSRV 620
+ E R++ L+++L L K++ ++D + WI++K++ ++ E +D++ ++ R
Sbjct: 819 KEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF 878
Query: 621 QKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKG 680
+ E E+ +++ + + ++++ GH + + + ++ + W + E +K
Sbjct: 879 ES---LEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKK 935
Query: 681 TQLHEANQQLQFENNAEDLQRWLEDVEWQVTS-EDYGKGLAEVQNRLRKHGLLESAVAAR 739
L A + + + W+ + + S +D G LA V RK +E + A
Sbjct: 936 DALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAI 995
Query: 740 QDQVDILTDLAAYFEEIGHPD-SKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLI 798
+ ++ L A E HPD ++ I +R + +E +K L R+ L + LQ
Sbjct: 996 EAKLSDLQKEAEKLES-EHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQF 1054
Query: 799 CRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNK 858
RD +D ++W+ T+ + S + L ++KLL +H I I ++E Q++ + G +
Sbjct: 1055 LRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG-E 1113
Query: 859 MVEEGHFAAE--DVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIR 916
MV +G A+ + R+++L+ L RQN L + +QQ+L D +AE ++
Sbjct: 1114 MVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLN 1173
Query: 917 EKEPIVDNTNYGADEEAAGALLKKHEAFLL-------DLNSFGDSMKALRNQANACQQQQ 969
+E ++ +T E A A +KK E F+ +N+ ++ + L + N +
Sbjct: 1174 NQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRI 1233
Query: 970 AAPVEGVAGEQR---------VMALYDFQ-----ARSPREVTMKKGDVLTLLSSINKD-- 1013
V+ + R +M L D + + +E+++ + + ++ D
Sbjct: 1234 QEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEA 1293
Query: 1014 ------WWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSL 1067
W K +A + ++ ++ + ++ ++ E + ++ + + L
Sbjct: 1294 RNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETE-AVVKEKLTGLHKMWEVL 1352
Query: 1068 LDRAEERRRRLLQRYNEFLLAYEAGDMLEWI----QEKKAENTGVELDDVWELQKKFDEF 1123
+ + +RL L D+ +W+ + ++++ G +L V L KK
Sbjct: 1353 ESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQML 1412
Query: 1124 QKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAH 1183
+ + + + ++ A L EG T E R + +++ L +E++ L ++
Sbjct: 1413 ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASK 1472
Query: 1184 AVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILG 1243
+ F+R+ +D + ++ ++ D G +L +VQ L ++++ ++++ ++ +
Sbjct: 1473 EIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIF 1532
Query: 1244 ETAERL-SESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQ 1302
E ++ + ++S + E ++++ +L + W L T+ R L EA + + A + +
Sbjct: 1533 ERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAE 1592
Query: 1303 NWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHA 1362
W+S + S+E A+D +L++HQ +E A T L S L+ H
Sbjct: 1593 AWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPE 1652
Query: 1363 SPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDD 1422
S I + V L+ E+R+ LD+ L D +E W+ RE S +
Sbjct: 1653 SERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHE 1712
Query: 1423 KSSLDSLEALMKKRDDLDKAITAQEG--KITDLEHFAESLIADEHYAKEEIATRLQRVLD 1480
++++R T G ++ + H A+ LI H IA + +
Sbjct: 1713 LGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNE 1772
Query: 1481 RWKALKAQLIDERTK-LGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYL 1539
W L +LID RT+ L L +FY D +E+ I + +E +D ++
Sbjct: 1773 AWADL-LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQR 1831
Query: 1540 KHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDK 1599
H TF H++ QV + L A D ++ K + E L E W LL+ +
Sbjct: 1832 MHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVL-EAWKSLLDACESR 1890
Query: 1600 GKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAR 1659
+L + + RF + +RD W+ + + +++ RD++S L+ HQ ++ E+ AR
Sbjct: 1891 RVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDAR 1950
Query: 1660 EDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFF 1719
D+ L + LL+ + ++I +K + ++ + + E L+ + QF
Sbjct: 1951 NDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFS 2010
Query: 1720 QDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLE 1759
+D E+W+ + +SS++ G+ + V+ L+K+H+ E
Sbjct: 2011 RDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFE 2050
Score = 432 bits (1110), Expect = e-120
Identities = 419/1995 (21%), Positives = 872/1995 (43%), Gaps = 184/1995 (9%)
Query: 228 NHPDLPLIQSKQNEVNAAWERLRGLALQRQ---KALSNAAN----LQRFKRDVTEAIQWI 280
+HPD I + + +++ LA++ + K L NA +++++ ++ ++WI
Sbjct: 246 DHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWI 305
Query: 281 KEKEPVLTSEDYGKDLVASEG---LFHSHKGLER--------NLAVMSDKVK-ELCAKAE 328
++ +L + + LV + F++++ +E+ NL V+ ++ ++ A +
Sbjct: 306 EQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQ 365
Query: 329 KLTLSHPSDAPQIQEMKEDLVSSWE------HIRALATS----RYEKLQATYWYHRFSSD 378
K+ + P+ ++ D+ +WE H R LA R EKL+ RF
Sbjct: 366 KVYM------PREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLA--RRFDRK 417
Query: 379 FDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN 438
W++E ++ D D+ E +H+ + +I +Y++R Q+ ++L
Sbjct: 418 AAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEA 477
Query: 439 ANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAF 498
N+ + + + + W LLEL R ++ E L +++ + WM +
Sbjct: 478 ENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVL 537
Query: 499 LENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGD-DHYDSENIKAIR 557
+ ++D G L E LLQKH E Q E++ V+ +A K D + Y + + IR
Sbjct: 538 VLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIR 597
Query: 558 DGLLARRDALREK---AATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDY-KDI 613
D + +E AA RR L+ES L K + + + + WI +K+K+ +DY KD+
Sbjct: 598 DRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDL 657
Query: 614 QNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELL 673
++ + K + FE E++ E K G++MI H+ S+ + R+ + W L
Sbjct: 658 TSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLE 717
Query: 674 EATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLE 733
+ + + +L EA+ QF+ +A+D+ W+ D+ V+S D G Q+ ++KH +
Sbjct: 718 QLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVA 777
Query: 734 SAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLL 793
+A + +D L + A+ + H +S D+R R + R++ + E RK+ L D L
Sbjct: 778 EEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTL 836
Query: 794 HLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEIT 853
L + + + E WI E E + + + L + + +R + + + R+ +
Sbjct: 837 ALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVN 896
Query: 854 ERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAET 913
+ +++ GH + +++ ++ LN R R+++ L + + Q Y + +E ++
Sbjct: 897 QIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKS 956
Query: 914 WIREKEPIVDNT-NYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAP 972
WIREK ++++T + G D AL +K DL + + L+ +A
Sbjct: 957 WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEA---------- 1006
Query: 973 VEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVR 1032
+++ + + QA++ +L+ L+ I+ W
Sbjct: 1007 -------EKLESEHPDQAQA----------ILSRLAEISDVW------------------ 1031
Query: 1033 RLAHDEFPMLPQRRREEPGNITQRQEQIEN--QYRSLLDRAEERRRRLLQRYNEFLLAYE 1090
+E + R G ++ Q+ + + ++S L R + A
Sbjct: 1032 ----EEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQT--------------AIA 1073
Query: 1091 AGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLL 1150
+ DM + E + T E ++ + D +++D ++RD+ +++ +G
Sbjct: 1074 SEDMPNTLTEAEKLLTQHE-----NIKNEIDNYEEDYQ----KMRDMG----EMVTQGQT 1120
Query: 1151 TPEGAQIRQEL---NSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALS 1207
+ +RQ L ++ W L ++ + ++ LL +HA + F R+ + + + L+
Sbjct: 1121 DAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1180
Query: 1208 AADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMEL 1267
+ + L +A ++ E F + +K+ + ET RL ++ +Q + +
Sbjct: 1181 HTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSI 1240
Query: 1268 NEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAED-LTGIEI 1326
++ + + L + + FL ++L WI+ M+++Q+++ D +
Sbjct: 1241 DDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINE--KMLTAQDMSYDEARNLHS 1298
Query: 1327 LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEK 1386
+HQ A++ + +E +LI +++KL + + LE +
Sbjct: 1299 KWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQT 1358
Query: 1387 RKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSS-LDSLEALMKKRDDLDKAITA 1445
+ + L + ++F +C ++ W+ E+ ++SDD L S+ L+KK+ L+ +
Sbjct: 1359 KAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEV 1418
Query: 1446 QEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQF 1505
++ +I +L+ A++L + E + +E+ ++ V ++ L L + + L + QF
Sbjct: 1419 RKKEIEELQSQAQAL-SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQF 1477
Query: 1506 YRDLEELEEWISEMLPTACDESY-KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNS 1564
RD+E+ W+ E +P A + + +Q K+QT E+ G ++ + +
Sbjct: 1478 NRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQN 1537
Query: 1565 LIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLS 1624
++ S+ + EA++++L LK+ W L+E T + ++L EA R Q++ + E W+S
Sbjct: 1538 IVTDSS-SLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMS 1596
Query: 1625 EAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQI 1684
E E + +++A+D SA ++LKKHQ+LE+ + + + L+ + L++ ++I
Sbjct: 1597 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1656
Query: 1685 VKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRD 1744
++ V+K + +++LA KL E + LFQ +++DD E WI E+ + S + G+D
Sbjct: 1657 SMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQD 1716
Query: 1745 LQGVQNLLKKHKRLEGEL-VAHEPAIQNVLDMAEKL-----KDKAAVGQEEIQLRLAQFV 1798
+ V L ++ + + + + V +A++L D A + + + L
Sbjct: 1717 YEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLN----- 1771
Query: 1799 EHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLL 1858
E W L EL R L S E +F +A+E I +K+ + + G ++L
Sbjct: 1772 EAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHK-KLPEELGRDQNTVETLQ 1830
Query: 1859 MKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIA 1918
H E+D T+V+ + Q + + + +I + + E SL A
Sbjct: 1831 RMHTTFEHDIQALGTQVRQL--QEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACE 1888
Query: 1919 AWKLQLED-DYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASL 1977
+ +++L D F+ F+ D++ W+ D ++ D+ L+ + A +
Sbjct: 1889 SRRVRLVDTGDKFRFFSMVRDLM-LWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEI 1947
Query: 1978 QSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLP 2037
+ + + +L L++ +H S+ I+E+ L ++ +++++ R + L L
Sbjct: 1948 DA-RNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMID-KWEDRWEWLRLILE 2005
Query: 2038 LQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQA 2097
+ +F+ AS W E LS S++E+ +L K HE F S A
Sbjct: 2006 VH-------QFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDE 2058
Query: 2098 DFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFE 2157
F L L T+E+L E R Q+ ++E R+ + E
Sbjct: 2059 RFSALERL----------------TTLELL-----------EVRRQQEEEERKRRPPSPE 2091
Query: 2158 MCQEFEQNASTFLQW 2172
+ + A + QW
Sbjct: 2092 PSTKVSEEAESQQQW 2106
Score = 416 bits (1069), Expect = e-115
Identities = 342/1497 (22%), Positives = 676/1497 (45%), Gaps = 62/1497 (4%)
Query: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY-E 82
I++R + YQ + AER +LE+S L F + + WI EK IL+ Y +
Sbjct: 596 IRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 655
Query: 83 DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDL 142
D T++ KH++ E E+ +S + K E+ H E+ + I +R W
Sbjct: 656 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWAN 715
Query: 143 LLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFED 202
L +L+ + +L A Q+ + DI W+ D I +S ++G D T+ L KK +D
Sbjct: 716 LEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKD 775
Query: 203 FQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSN 262
E+ + +++ A+ +E H + P ++ + + + ++ + L R++AL +
Sbjct: 776 VAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQALQD 834
Query: 263 AANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKE 322
L + + WI EKE L + + L E + H + LE + + +V
Sbjct: 835 TLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAV 894
Query: 323 LCAKAEKLTLS-HPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDE 381
+ A +L S HPS+ +I+ ++ L + W R L + + L + + + +E
Sbjct: 895 VNQIARQLMHSGHPSE-KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNE 953
Query: 382 LSGWMNEKTAAI-NADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNAN 440
W+ EKT I + +L D+AG L + + ++ + + + + + L + +
Sbjct: 954 TKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEH 1013
Query: 441 HEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLE 500
+ + + ++ + + W + R + F RD + SW+SR + +
Sbjct: 1014 PDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA 1073
Query: 501 NEDLGNSLGSAEALLQKHEDFEEAFTAQEE---KIITVDKTATKLIGDDHYD--SENIKA 555
+ED+ N+L AE LL +HE+ + EE K+ + + T+ D Y + ++A
Sbjct: 1074 SEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQA 1133
Query: 556 IRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKK-KLADDEDYKDIQ 614
+ G + L + R+ LL +S Q+ D+ + ++N ++ LA E ++
Sbjct: 1134 LDTGW----NELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLE 1189
Query: 615 NLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLE 674
++ ++KQ+ F + N+ ++ + +TG+ ++ G+ SD + ++ + + E
Sbjct: 1190 GAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRE 1249
Query: 675 ATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLA-EVQNRLRKHGLLE 733
+ +L + +F + ++L W+ E +T++D A + ++ KH
Sbjct: 1250 TASELLMRLKDNRDLQKFLQDCQELSLWIN--EKMLTAQDMSYDEARNLHSKWLKHQAFM 1307
Query: 734 SAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLL 793
+ +A+ ++ +D + ++ + L +E L+ T+ ++L D
Sbjct: 1308 AELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDAN 1367
Query: 794 HLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEIT 853
+L + D + W+ E S GKDL + LL + +++ + + I+E+
Sbjct: 1368 KAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQ 1427
Query: 854 ERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAET 913
+ + +EG E + R+ + ME L R+ N L A+ + Q+ D+ +
Sbjct: 1428 SQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHN-LLASKEIHQFNRDVEDEIL 1486
Query: 914 WIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDL-------------------NSFGDS 954
W+ E+ P+ +T++G + + L+KK++ ++ +S S
Sbjct: 1487 WVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLS 1546
Query: 955 MKALRNQANACQQQQAAPVEGVAGEQRVM------ALYDFQARSPREVTMKKGDVLTLLS 1008
+A+R + +Q +E R + Y F A + E M + ++ +
Sbjct: 1547 AEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDA-AEAEAWMSEQELYMMSE 1605
Query: 1009 SINKDWWKVEA--ADHQGIVPAV-----YVRRLAHDEFPMLPQRRREEPGNITQRQEQIE 1061
KD + HQ + AV V +L+ ++ E I+ RQ +++
Sbjct: 1606 EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESE-RISMRQSKVD 1664
Query: 1062 NQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----AENTGVELDDVWELQ 1117
Y L D AEERR +L +R+ F L E D+ +WI E++ + G + + V LQ
Sbjct: 1665 KLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQ 1724
Query: 1118 KKFDEFQKDL-NTNEPRLRDINKVADDLLFEGLLTPEG-AQIRQELNSRWGSLQRLADEQ 1175
++F EF +D N + R+ +N +AD+L+ G A+ + LN W L L D +
Sbjct: 1725 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1784
Query: 1176 RQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPL 1235
Q+L +++ + F+ +A + +I+ K + L + G D +V+ LQR H FE D+ L
Sbjct: 1785 TQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQAL 1843
Query: 1236 GDKVTILGETAERLSESHP-DATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLF 1294
G +V L E A RL ++ D +D+Q+++ E+ EAW+ L + R+ L + + F
Sbjct: 1844 GTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRF 1903
Query: 1295 LSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAE 1354
S RDL W+ + + +QE D++ +E+L+ HQ +A+++A +F +
Sbjct: 1904 FSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKS 1963
Query: 1355 LIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVAR 1414
L+ H+AS EI++KL + +R ++ WE R + L LE+ F + E+W++ +
Sbjct: 1964 LLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQ 2023
Query: 1415 ENSLRSDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEE 1470
E L S + S+D +E L+K+ + +K+ + + + LE + + +EE
Sbjct: 2024 EPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEE 2080
Score = 325 bits (833), Expect = 3e-88
Identities = 295/1398 (21%), Positives = 605/1398 (43%), Gaps = 98/1398 (7%)
Query: 826 IASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLR 885
I SK N +V + I + ER K E A + R + L Q
Sbjct: 356 IQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFD 415
Query: 886 ARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFL 945
+AA R ETW+ E + +V N+G D A A KKHEA
Sbjct: 416 RKAAMR--------------------ETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIE 455
Query: 946 LDLNSFGDSMKALRNQANACQQQQAAPVEGV-AGEQRVMALYDF-----QARSPREVTMK 999
D+ ++ + ++A+ A + + ++ + A + V+ L+++ +AR R + M
Sbjct: 456 TDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQR-LEMN 514
Query: 1000 KG------DVLTLLSSINKDWWKVEAADHQ----GIVPAVYVRRLAHDEFPMLPQRRRE- 1048
G ++L ++ +++ V + D+ G+ + L + + +R R
Sbjct: 515 LGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGV 574
Query: 1049 -----------------EPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEA 1091
+P I R +E Y+ L A ERR RL + + +E
Sbjct: 575 NASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEM 634
Query: 1092 GDMLEWIQEKK----AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFE 1147
+ WI+EK+ +++ G +L V L K F+ +++ K +D++ E
Sbjct: 635 AEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAE 694
Query: 1148 GLLTPEGAQIRQE---LNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQ 1204
E +IR+ + +W +L++L+ +++ L A + F +ADD + +
Sbjct: 695 EHFGSE--KIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILK 752
Query: 1205 ALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQK 1264
+S++D G D +S Q+L ++H+ ++ + L E A L + H + + D++ +
Sbjct: 753 IVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAE-SPDVRGRL 811
Query: 1265 MELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGI 1324
+ E ++++ T+ RK++L + Y S+A + WI +++ ++ E L +
Sbjct: 812 SGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDL 871
Query: 1325 EILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAW 1384
E++ R + +M +A + + +L+ SGH + EI+ + + +
Sbjct: 872 EVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELV 931
Query: 1385 EKRKKILDQCLELQMFQGNCDQVESWMVARENSLRS--DDKSSLDSLEALMKKRDDLDKA 1442
+++K L L +Q + C++ +SW+ + + S D + L + AL +K +++
Sbjct: 932 DRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERD 991
Query: 1443 ITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANL 1502
+ A E K++DL+ AE L ++ + I +RL + D W+ +K L + LG+ + L
Sbjct: 992 LVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKL 1051
Query: 1503 KQFYRDLEELEEWISEMLPTACDESYKDA-TNIQRKYLKHQTFAHEVDGRSEQVHGVINL 1561
+QF RDL++ + W+S E + T ++ +H+ +E+D E + ++
Sbjct: 1052 QQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDM 1111
Query: 1562 GNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEF 1621
G ++ D ++++L+ L W+ L + ++ L+++ Q+F + E
Sbjct: 1112 G-EMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEA 1170
Query: 1622 WLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNV 1681
+L+ E +LA + L A +KK + M A E+ + + L+S G N
Sbjct: 1171 FLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINS 1230
Query: 1682 DQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDY 1741
D+I +K D+++ R +E A+ +LK+ L +F QD + WI EK++ Y
Sbjct: 1231 DRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSY 1290
Query: 1742 GRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHW 1801
+ + + + KH+ EL +++ + + +L + + ++ +L + W
Sbjct: 1291 D-EARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMW 1349
Query: 1802 EKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKH 1861
E L+ + + +L ++ + F Q+ + + W++ + D G L + LL K
Sbjct: 1350 EVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQ 1409
Query: 1862 EALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWK 1921
+ LEN V + ++ + +Q + + QE E+ SK + K L + + K
Sbjct: 1410 QMLENQMEVRKKEIEELQSQAQ----ALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERK 1465
Query: 1922 LQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQ 1981
L +FN + W+ ++ + +G +L L+ K TL +Q
Sbjct: 1466 HNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQG-H 1524
Query: 1982 QERLPEITDLKDKLISAQHNQS-KAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQK 2040
Q R+ +I + +++ + S +AI +R A L + W L+E + ++L E +
Sbjct: 1525 QPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEE----AHR 1580
Query: 2041 AEDLFVEFAHKASALNNWCEKM--EENLSEPVHCVSLNEIRQ-LQKDHEDFLASLARAQA 2097
A+ + + A + ++ M EE + VS+ + Q L++ ED+ ++ +
Sbjct: 1581 AQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQ--- 1637
Query: 2098 DFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFE 2157
L + + + A P S + +++ + L D+ EER +L + + F+
Sbjct: 1638 ----LSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERH----RLFQ 1689
Query: 2158 MCQEFEQNASTFLQWILE 2175
+ +E + QWI E
Sbjct: 1690 LNREVDD----LEQWIAE 1703
Score = 324 bits (830), Expect = 7e-88
Identities = 335/1653 (20%), Positives = 685/1653 (41%), Gaps = 86/1653 (5%)
Query: 22 EEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIME-KVNILTDKS 80
+ I R+ V+ ++ E + R Q+LE + LQ ++ + W+ E KV +L+
Sbjct: 484 KRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 543
Query: 81 YEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAH----EETKAHIEEL 136
+ ++ QKH +EA++ ++ + + + ++ T G + + + +
Sbjct: 544 GKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHM 603
Query: 137 RHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVL 196
+ L +L E+ +L + + ++ E A+ WI +KE I +S + G+D L
Sbjct: 604 EFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRL 663
Query: 197 HKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQR 256
K F+ E+ + G + + + E H I+ + + W L L+ R
Sbjct: 664 LSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIR 723
Query: 257 QKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVM 316
+K L A+ L +F+ D + W+ + +++S D G D +++ L HK + +A
Sbjct: 724 KKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANY 783
Query: 317 SDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFS 376
+ L +A L H +++P ++ + ++ + L R + LQ T ++
Sbjct: 784 RPTLDTLHEQASALPQEH-AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMF 842
Query: 377 SDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDL 436
S+ D W++EK +N ++P + EV+ R + + E+++ R ++ + L
Sbjct: 843 SEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQL 902
Query: 437 VNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQE 496
+++ H + E++ + + L+ W+ EL D + L ++ + + SW+ +
Sbjct: 903 MHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKT 962
Query: 497 AFLEN-EDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555
+E+ +DLGN L AL +K E A E K+ + K A KL +H D +A
Sbjct: 963 KVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL-ESEHPD--QAQA 1019
Query: 556 IRDGLLARRDALREKAAT---RRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD 612
I L D E T R L E+ LQ+ D DD ++W+++ + E D
Sbjct: 1020 ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASE---D 1076
Query: 613 IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVT--------TRLSE 664
+ N + +K + + K +++N ++ Q+M + G + T RL
Sbjct: 1077 MPNTLTEAEKLLTQHENI---KNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQA 1133
Query: 665 VASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQN 724
+ + W EL + + + L +++ QF + + + +L + E+ + + L +
Sbjct: 1134 LDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEA 1193
Query: 725 RLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLAT 784
++K + + A +++++ + + G+ +S I+ + +S+ R +E +
Sbjct: 1194 AIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASE 1253
Query: 785 RKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIAS 844
+L D LQ +D ++ WI E +A + K L +H+ + +AS
Sbjct: 1254 LLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWL-KHQAFMAELAS 1312
Query: 845 HEPRIQEITERGNKMVEEGHFAAEDVASRVKSLN---QNMESLRARAARRQNDLEANVQF 901
++ + +I + G +++ E V ++ L+ + +ES A+R D F
Sbjct: 1313 NKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELF 1372
Query: 902 QQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQ 961
Q ADL + W+ E + + +YG D + LLKK + + ++ L++Q
Sbjct: 1373 TQSCADL---DKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ 1429
Query: 962 ANACQQQQAAPVE----GVAGEQRVMALYD------FQARSPREVTMKKGDVLTLLSSIN 1011
A A Q+ + E + + + M L + + +E+ DV + +
Sbjct: 1430 AQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVG 1489
Query: 1012 KDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRS----- 1066
+ + DH + V + + Q + +I +R + I S
Sbjct: 1490 ERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA 1549
Query: 1067 --------------LLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----AENTGV 1108
L++ E+R RRL + + ++A + W+ E++ +E
Sbjct: 1550 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1609
Query: 1109 ELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQ-ELNSRWGS 1167
+ + KK ++ + + ++K + L+ + E +RQ +++ +
Sbjct: 1610 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAG 1669
Query: 1168 LQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEG 1227
L+ LA+E+R L H + +RE DD ++ I ++ + + G D V LQ R
Sbjct: 1670 LKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFRE 1729
Query: 1228 FERDLVPLG-DKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLN 1286
F RD +G ++V + A+ L S + K LNEAW DL R + L
Sbjct: 1730 FARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILA 1789
Query: 1287 EAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQ 1346
+ + + F A+++ I + +EL D +E L H D++A +
Sbjct: 1790 ASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVR 1848
Query: 1347 ALEDFSAEL--IDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNC 1404
L++ +A L +G A +++ + ++ + L+ +R +++D + + F
Sbjct: 1849 QLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR 1908
Query: 1405 DQVESWMVARENSLRSDDK-SSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIAD 1463
D + WM + + +K + S+E LM + I A+ T +SL+A
Sbjct: 1909 D-LMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR 1967
Query: 1464 EHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLP-T 1522
+HYA EEI +L ++ ++ K + + D L + QF RD E W+ P
Sbjct: 1968 KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2027
Query: 1523 ACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQL 1582
+ E + +++ +H+ F E+ + L E ++ +
Sbjct: 2028 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTL-----------ELLEVRR 2076
Query: 1583 EQLKEHWDHLLERTNDKGKKLNEASRQQRFNTS 1615
+Q +E K EA QQ+++TS
Sbjct: 2077 QQEEEERKRRPPSPEPSTKVSEEAESQQQWDTS 2109
Score = 322 bits (826), Expect = 2e-87
Identities = 304/1384 (21%), Positives = 590/1384 (42%), Gaps = 125/1384 (9%)
Query: 7 ETVVESSGPKVLETAE--EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64
+T+ E + E AE +++ R + RY+ E R Q L+D+ L +AD
Sbjct: 788 DTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADA 847
Query: 65 LGKWIMEKV----NILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFT 120
WI EK N+ + ED IQ ++ +SLE E+ ++ ++ + + +
Sbjct: 848 CELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPEMNNQASRVAVVNQIARQLMH 904
Query: 121 MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDK-EA 179
GH + +E KA ++L W EL K D LL AL Q Y EC + WI +K +
Sbjct: 905 SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 964
Query: 180 IATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPD-LPLIQSK 238
I ++ +LG D L +K + +LVA E ++ ++ + A E E HPD I S+
Sbjct: 965 IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEA-EKLESEHPDQAQAILSR 1023
Query: 239 QNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVA 298
E++ WE ++ R+ +L A+ LQ+F RD+ + W+ + + SED L
Sbjct: 1024 LAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTE 1083
Query: 299 SEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQ--IQEMKEDLVSSWEHIR 356
+E L H+ ++ + + +++ E +T +DA +++ + L + W +
Sbjct: 1084 AEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQ-TDAQYMFLRQRLQALDTGWNELH 1142
Query: 357 ALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHK 416
+ +R L ++ Y +F D + ++N + + E+PT + G E + + +
Sbjct: 1143 KMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFM 1202
Query: 417 HEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCL 476
+D+ +++ + ETG+ LV+ + SD ++EK++ +D+ E E + +
Sbjct: 1203 TTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNR 1262
Query: 477 DFHLFYRDSEQVDSWMSRQEAFLENEDLG-NSLGSAEALLQKHEDFEEAFTAQEEKIITV 535
D F +D +++ W++ E L +D+ + + + KH+ F + +E + +
Sbjct: 1263 DLQKFLQDCQELSLWIN--EKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKI 1320
Query: 536 DKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLK 595
+K +LI + +K GL + L T+ + L ++ + + DL
Sbjct: 1321 EKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLD 1380
Query: 596 NWINKKKKLADDEDY-KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYA 654
W++ + +DY KD+ ++ ++KQQ+ E ++ V K ++E +Q Q + + G +
Sbjct: 1381 KWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-S 1439
Query: 655 SDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSED 714
+D V ++ V + + ELLE ++ L + + QF + ED W+ + TS D
Sbjct: 1440 TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTD 1499
Query: 715 YGKGLAEVQNRLRKHGLLESAVAARQDQVD--------ILTDLAAYFEEIGHPDSKDIRA 766
+G L VQ ++K+ L+ + Q ++D I+TD ++ E IR
Sbjct: 1500 HGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA-------IRQ 1552
Query: 767 RQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLI 826
R L + L E R ++L + Q D + EAW+ E E S KD
Sbjct: 1553 RLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQ 1612
Query: 827 ASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRA 886
++ +L +H+++ + + + + ++++ +V + H +E ++ R +++ L+
Sbjct: 1613 SAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKD 1672
Query: 887 RAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLL 946
A R+ L+ + Q ++ + E WI E+E + + G D E L ++ F
Sbjct: 1673 LAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFAR 1732
Query: 947 DLNSFG----DSMKALRNQANACQQQQAAPV---------------EGVAGEQRVMA--- 984
D + G D++ L ++ AA + E + +++A
Sbjct: 1733 DTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASY 1792
Query: 985 ---------------LYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAV 1029
+ D + P E+ + V TL ++A Q
Sbjct: 1793 ELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQ------ 1846
Query: 1030 YVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAY 1089
VR+L D + ++ +I +R+ ++ ++SLLD E RR RL+ ++F
Sbjct: 1847 -VRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFS 1905
Query: 1090 EAGDMLEWI---------QEKKAENTGVEL------DDVWELQKKFDEFQKDLNTNEPRL 1134
D++ W+ QEK + + VEL E+ + D F + + L
Sbjct: 1906 MVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLL 1965
Query: 1135 RDINKVADDLLFEGL-LTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREAD 1193
+ ++++ + L LT + ++ + RW L+ + + V F R+A
Sbjct: 1966 ARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILE-----------VHQFSRDAS 2014
Query: 1194 DTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESH 1253
+ + + LS+ + G + V+ L +RHE FE+ ++ + L ERL+
Sbjct: 2015 VAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL----ERLT--- 2067
Query: 1254 PDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVS 1313
+EL E Q ++RK + +A Q W +S G VS
Sbjct: 2068 ----------TLELLEVRR--QQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVS 2115
Query: 1314 SQEL 1317
L
Sbjct: 2116 QNGL 2119
Score = 247 bits (631), Expect = 9e-65
Identities = 282/1354 (20%), Positives = 559/1354 (41%), Gaps = 87/1354 (6%)
Query: 931 EEAAGALLKKHEAFLLDLNS--FGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDF 988
E A LL+ E ++ LN+ F +S+ ++ Q A + E+ + + F
Sbjct: 295 ESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLF 354
Query: 989 QARSPREVTMKKGDVLT---LLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQR 1045
+S +K + L+S INK W ++E A+H+ R LA
Sbjct: 355 TIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHE--------RELA---------- 396
Query: 1046 RREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAEN 1105
N RQE++E R +A R L + N+ L++ +N
Sbjct: 397 ----LRNELIRQEKLEQLARRFDRKAAMRETWLSE--NQRLVS--------------QDN 436
Query: 1106 TGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSR- 1164
G +L V KK + + D+ E R++ + VA +L E + R++ R
Sbjct: 437 FGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRL 496
Query: 1165 WGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRR 1224
W L L +RQ L ++ +E + +++ + + D G L V+ L ++
Sbjct: 497 WEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQK 556
Query: 1225 HEGFERDLVPLGDKVTILGETAERLS---ESHPDATEDLQRQKM-ELNEAWEDLQGRTKD 1280
H E D+ ++V + +A++ + E + + R ++ + +++L +
Sbjct: 557 HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAE 616
Query: 1281 RKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEA 1340
R+ L E+++ + F + + + WI ++SS + +DLT + LL +H+ +M
Sbjct: 617 RRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSG 676
Query: 1341 EAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMF 1400
+ F+ ++I H S +I +++ ++ + +LE+ RKK L++ L F
Sbjct: 677 RSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQF 736
Query: 1401 QGNCDQVESWMVARENSLRSDDKSSLD-SLEALMKKRDDLDKAITAQEGKITDLEHFAES 1459
Q + D +++WM+ + S D + S ++L+KK D+ + I A D H S
Sbjct: 737 QADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEI-ANYRPTLDTLHEQAS 795
Query: 1460 LIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISE- 1518
+ EH ++ RL + +R+K + + L D L + + + + E WI E
Sbjct: 796 ALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEK 855
Query: 1519 ---MLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNE 1575
+ E +D IQ ++ ++ E++ ++ +V V + L+ +E
Sbjct: 856 EQWLNNMQIPEKLEDLEVIQHRF---ESLEPEMNNQASRVAVVNQIARQLMHSG--HPSE 910
Query: 1576 EAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSE-AETLLAMKD 1634
+ +K Q ++L W E + K L A Q ++ + + W+ E + + + +D
Sbjct: 911 KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 970
Query: 1635 QARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKR 1694
DLA L +K +ER+++A E L DL AE L S I+ + ++
Sbjct: 971 LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1030
Query: 1695 FLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKK 1754
+ ++ L EA L QF +DLDD +SW+ ++S+D L + LL +
Sbjct: 1031 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQ 1090
Query: 1755 HKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEE-IQLRLAQFVEHWEKLKELAKARGL 1813
H+ ++ E+ +E Q + DM E + Q ++ RL W +L ++ + R
Sbjct: 1091 HENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQN 1150
Query: 1814 KLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHET 1873
L +S Y QF+++ ++ EA++N + + + TL ++ + K E +E
Sbjct: 1151 LLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEE 1210
Query: 1874 RVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEF 1933
++ V G + V + I K+++++++ + + ++L+D+ Q+F
Sbjct: 1211 KINAVVETGRRL---VSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKF 1267
Query: 1934 NWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKD 1993
+ WI +K + + + + + + + K A L S +E L +I
Sbjct: 1268 LQDCQELSLWINEKMLTAQ-DMSYDEARNLHSKWLKHQAFMAELAS-NKEWLDKIEKEGM 1325
Query: 1994 KLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKAS 2053
+LIS + ++E+ L K WE L + Q+L + KAE F +
Sbjct: 1326 QLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFD----ANKAE----LFTQSCA 1377
Query: 2054 ALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALG 2113
L+ W +E + + L + L K + + + + + L Q + G
Sbjct: 1378 DLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEG 1437
Query: 2114 VPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173
+ + V + + L + E + L +E Q F ++ + W+
Sbjct: 1438 KSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQ---------FNRDVEDEILWV 1488
Query: 2174 LETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL-EDALILD-- 2230
E T++ ++ N+ QKEIQ + ++ I + N+ D+ L
Sbjct: 1489 GERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE 1548
Query: 2231 -IKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAK 2263
I+ L Q W L + + LE+ +A+
Sbjct: 1549 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQ 1582
Score = 42.0 bits (97), Expect = 0.007
Identities = 30/142 (21%), Positives = 63/142 (44%), Gaps = 3/142 (2%)
Query: 2127 LERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLL 2186
+ + W+ L ERE L+ E RQ K ++ + F++ A+ W+ E + +
Sbjct: 379 INKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFG 438
Query: 2187 KETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTI---GLAQQWD 2243
+ +E+ + ++ + +I A + ++ +V + LE DIK T + + W+
Sbjct: 439 FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWE 498
Query: 2244 QLYQLGLRMQHNLEQQIQAKDI 2265
L +L + LE + + I
Sbjct: 499 YLLELLRARRQRLEMNLGLQKI 520
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 495 bits (1274), Expect = e-139
Identities = 353/1389 (25%), Positives = 641/1389 (46%), Gaps = 42/1389 (3%)
Query: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKS 80
+E+I+ER + ++ + ++ A R ++LE++ L F+ DADD+ W+++ + I++
Sbjct: 712 SEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 771
Query: 81 Y-EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHL 139
D + Q +KH+ + E+ + L + + H+ + + + +
Sbjct: 772 VGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHE-QASALPQEHAESPDVRGRLSGIEER 830
Query: 140 WDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKK 199
+ + ELT + L L + E WI +KE ++++ E E EV+ +
Sbjct: 831 YKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHR 890
Query: 200 FEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKA 259
FE + E+ + RV VNQ A + HP I+++Q+++N W + R L +++ A
Sbjct: 891 FESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDA 950
Query: 260 LSNAANLQRFKRDVTEAIQWIKEKEPVLTS-EDYGKDLVASEGLFHSHKGLERNLAVMSD 318
L +A ++Q + + E WI+EK V+ S +D G DL L G+ER+L +
Sbjct: 951 LLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEA 1010
Query: 319 KVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSD 378
K+ +L +AEKL HP A I ++ WE ++ +R L +F D
Sbjct: 1011 KLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRD 1070
Query: 379 FDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN 438
D+ W++ AI ++++P + E LL +H+ K+EID+Y++ +Q + G+ +
Sbjct: 1071 LDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQ 1130
Query: 439 ANHEASDE-VREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEA 497
+A +R++++ LD W L ++W+ R Q + F RD++Q +++++ QE
Sbjct: 1131 GQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEY 1190
Query: 498 FLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIR 557
L + ++ +L AEA ++K EDF A EEKI V +T +L+ D + +S+ I+
Sbjct: 1191 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1250
Query: 558 DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLK 617
D + R RE A+ LK++ LQK +D +L WIN+K A D Y + +NL
Sbjct: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1310
Query: 618 SRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATK 677
S+ K Q F ELA NK L+ I+K G ++I V +L+ + +WE L T+
Sbjct: 1311 SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ 1370
Query: 678 QKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVA 737
K +L +AN+ F + DL +WL +E Q+ S+DYGK L V L+K +LE+ +
Sbjct: 1371 TKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQME 1430
Query: 738 ARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQL 797
R+ +++ L A + G + ++ +++ ++ +F L EPL RK LL +
Sbjct: 1431 VRKKEIEELQSQAQALSQEG-KSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQ 1489
Query: 798 ICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGN 857
RD EDE W+ E P ATST G +L + L+ +++ + + I H+PRI +I ER
Sbjct: 1490 FNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQ 1549
Query: 858 KMV-EEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIR 916
+V + +AE + R+ L Q L +R LE + QQY D EAE W+
Sbjct: 1550 NIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMS 1609
Query: 917 EKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGV 976
E+E + + DE++A ++LKKH+ + + +++ L + A E +
Sbjct: 1610 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669
Query: 977 AGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEA-ADHQGIVPAVYVRRLA 1035
+ Q + + E K D L +N++ +E + +V +
Sbjct: 1670 SMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQD 1729
Query: 1036 HDEFPMLPQRRRE---EPGNITQR--------------------------QEQIENQYRS 1066
++ ML +R RE + GNI Q ++ + +
Sbjct: 1730 YEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWAD 1789
Query: 1067 LLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK---AENTGVELDDVWELQKKFDEF 1123
LL+ + R + L Y ++A ++ IQ+K E G + + V LQ+ F
Sbjct: 1790 LLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTF 1849
Query: 1124 QKDLNTNEPRLRDINKVADDL--LFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGS 1181
+ D+ ++R + + A L + G + + E+ W SL + +R L
Sbjct: 1850 EHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVD 1909
Query: 1182 AHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTI 1241
F D +E + + A + D+ SV+ L H+G + ++ D T
Sbjct: 1910 TGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTT 1969
Query: 1242 LGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDL 1301
E + L A+E+++ + ++L E +++ + +DR E L + + F A
Sbjct: 1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029
Query: 1302 QNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSA-ELIDSGH 1360
+ W+ +SS+E+ + + +E L++RH+ F ALE + EL++
Sbjct: 2030 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRR 2089
Query: 1361 HASPEIEKK 1369
E K+
Sbjct: 2090 QQEEEERKR 2098
Score = 442 bits (1136), Expect = e-123
Identities = 413/1945 (21%), Positives = 851/1945 (43%), Gaps = 113/1945 (5%)
Query: 49 LEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPT-----NIQG-----------KYQ 92
+E ++ ++ A DL +WI + + IL ++ + + +Q K+
Sbjct: 298 IETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFT 357
Query: 93 KHQSLEAEVQT-KSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTL--- 148
+ +LE + T +S++ + +K R S + +E+ H +L L L
Sbjct: 358 EKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQ 417
Query: 149 EKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELV 208
EK +QL R + ++E W+ + + + + G D E KK E + ++
Sbjct: 418 EKLEQLARRFDRKAAMRET-----WLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIA 472
Query: 209 AKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQR 268
A E RV V A E EN+ D+ I ++++ V WE L L R++ L LQ+
Sbjct: 473 AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQK 532
Query: 269 FKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAE 328
+++ + W+ E + ++ S+DYGK L+ E L H +E ++ + +++V+ + A A+
Sbjct: 533 IFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQ 592
Query: 329 KLTLS----HPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSG 384
K P D I++ + ++ + LA R +L+ + +F + E G
Sbjct: 593 KFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEG 652
Query: 385 WMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEAS 444
W+ EK +++D+ D+ LL +H+ + E+ F+ A + G+D++ H S
Sbjct: 653 WIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGS 712
Query: 445 DEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDL 504
+++RE++ + W L +L R ++ E+ H F D++ +D+WM + + D+
Sbjct: 713 EKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDV 772
Query: 505 GNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARR 564
G+ S ++L++KH+D E + T+ + A+ L +H +S +++ G+ R
Sbjct: 773 GHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERY 831
Query: 565 DALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADD----EDYKDIQNLKSRV 620
+ E R++ L+++L L K++ ++D + WI++K++ ++ E +D++ ++ R
Sbjct: 832 KEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF 891
Query: 621 QKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKG 680
+ E E+ +++ + + ++++ GH + + + ++ + W + E +K
Sbjct: 892 ES---LEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKK 948
Query: 681 TQLHEANQQLQFENNAEDLQRWLEDVEWQVTS-EDYGKGLAEVQNRLRKHGLLESAVAAR 739
L A + + + W+ + + S +D G LA V RK +E + A
Sbjct: 949 DALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAI 1008
Query: 740 QDQVDILTDLAAYFEEIGHPD-SKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLI 798
+ ++ L A E HPD ++ I +R + +E +K L R+ L + LQ
Sbjct: 1009 EAKLSDLQKEAEKLES-EHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQF 1067
Query: 799 CRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNK 858
RD +D ++W+ T+ + S + L ++KLL +H I I ++E Q++ + G +
Sbjct: 1068 LRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG-E 1126
Query: 859 MVEEGHFAAE--DVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIR 916
MV +G A+ + R+++L+ L RQN L + +QQ+L D +AE ++
Sbjct: 1127 MVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLN 1186
Query: 917 EKEPIVDNTNYGADEEAAGALLKKHEAFLL-------DLNSFGDSMKALRNQANACQQQQ 969
+E ++ +T E A A +KK E F+ +N+ ++ + L + N +
Sbjct: 1187 NQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRI 1246
Query: 970 AAPVEGVAGEQR---------VMALYDFQ-----ARSPREVTMKKGDVLTLLSSINKD-- 1013
V+ + R +M L D + + +E+++ + + ++ D
Sbjct: 1247 QEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEA 1306
Query: 1014 ------WWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSL 1067
W K +A + ++ ++ + ++ ++ E + ++ + + L
Sbjct: 1307 RNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETE-AVVKEKLTGLHKMWEVL 1365
Query: 1068 LDRAEERRRRLLQRYNEFLLAYEAGDMLEWI----QEKKAENTGVELDDVWELQKKFDEF 1123
+ + +RL L D+ +W+ + ++++ G +L V L KK
Sbjct: 1366 ESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQML 1425
Query: 1124 QKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAH 1183
+ + + + ++ A L EG T E R + +++ L +E++ L ++
Sbjct: 1426 ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASK 1485
Query: 1184 AVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILG 1243
+ F+R+ +D + ++ ++ D G +L +VQ L ++++ ++++ ++ +
Sbjct: 1486 EIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIF 1545
Query: 1244 ETAERL-SESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQ 1302
E ++ + ++S + E ++++ +L + W L T+ R L EA + + A + +
Sbjct: 1546 ERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAE 1605
Query: 1303 NWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHA 1362
W+S + S+E A+D +L++HQ +E A T L S L+ H
Sbjct: 1606 AWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPE 1665
Query: 1363 SPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDD 1422
S I + V L+ E+R+ LD+ L D +E W+ RE S +
Sbjct: 1666 SERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHE 1725
Query: 1423 KSSLDSLEALMKKRDDLDKAITAQEG--KITDLEHFAESLIADEHYAKEEIATRLQRVLD 1480
++++R T G ++ + H A+ LI H IA + +
Sbjct: 1726 LGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNE 1785
Query: 1481 RWKALKAQLIDERTK-LGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYL 1539
W L +LID RT+ L L +FY D +E+ I + +E +D ++
Sbjct: 1786 AWADL-LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQR 1844
Query: 1540 KHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDK 1599
H TF H++ QV + L A D ++ K + E L E W LL+ +
Sbjct: 1845 MHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVL-EAWKSLLDACESR 1903
Query: 1600 GKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAR 1659
+L + + RF + +RD W+ + + +++ RD++S L+ HQ ++ E+ AR
Sbjct: 1904 RVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDAR 1963
Query: 1660 EDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFF 1719
D+ L + LL+ + ++I +K + ++ + + E L+ + QF
Sbjct: 1964 NDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFS 2023
Query: 1720 QDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNV--LDMAE 1777
+D E+W+ + +SS++ G+ + V+ L+K+H+ E + + L E
Sbjct: 2024 RDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLE 2083
Query: 1778 KLKDKAAVGQEEIQLR------------LAQFVEHWEKLK-ELAKARGL-------KLEE 1817
L+ + +EE + R A+ + W+ K E GL ++ E
Sbjct: 2084 LLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAE 2143
Query: 1818 SLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQN 1877
+++ + + A E+ + K + + D A T L A ET
Sbjct: 2144 TVDTSEMVNGATEQRT--SSKESSPIPSPTSDRKAKT--ALPAQSAATLPARTQET---- 2195
Query: 1878 VCAQGEDILNKVLQEESQNKEISSK 1902
AQ E LN+ + E+ NK+ SS+
Sbjct: 2196 PSAQMEGFLNRKHEWEAHNKKASSR 2220
Score = 432 bits (1110), Expect = e-120
Identities = 419/1995 (21%), Positives = 872/1995 (43%), Gaps = 184/1995 (9%)
Query: 228 NHPDLPLIQSKQNEVNAAWERLRGLALQRQ---KALSNAAN----LQRFKRDVTEAIQWI 280
+HPD I + + +++ LA++ + K L NA +++++ ++ ++WI
Sbjct: 259 DHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWI 318
Query: 281 KEKEPVLTSEDYGKDLVASEG---LFHSHKGLER--------NLAVMSDKVK-ELCAKAE 328
++ +L + + LV + F++++ +E+ NL V+ ++ ++ A +
Sbjct: 319 EQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQ 378
Query: 329 KLTLSHPSDAPQIQEMKEDLVSSWE------HIRALATS----RYEKLQATYWYHRFSSD 378
K+ + P+ ++ D+ +WE H R LA R EKL+ RF
Sbjct: 379 KVYM------PREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLA--RRFDRK 430
Query: 379 FDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN 438
W++E ++ D D+ E +H+ + +I +Y++R Q+ ++L
Sbjct: 431 AAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEA 490
Query: 439 ANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAF 498
N+ + + + + W LLEL R ++ E L +++ + WM +
Sbjct: 491 ENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVL 550
Query: 499 LENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGD-DHYDSENIKAIR 557
+ ++D G L E LLQKH E Q E++ V+ +A K D + Y + + IR
Sbjct: 551 VLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIR 610
Query: 558 DGLLARRDALREK---AATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDY-KDI 613
D + +E AA RR L+ES L K + + + + WI +K+K+ +DY KD+
Sbjct: 611 DRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDL 670
Query: 614 QNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELL 673
++ + K + FE E++ E K G++MI H+ S+ + R+ + W L
Sbjct: 671 TSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLE 730
Query: 674 EATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLE 733
+ + + +L EA+ QF+ +A+D+ W+ D+ V+S D G Q+ ++KH +
Sbjct: 731 QLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVA 790
Query: 734 SAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLL 793
+A + +D L + A+ + H +S D+R R + R++ + E RK+ L D L
Sbjct: 791 EEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTL 849
Query: 794 HLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEIT 853
L + + + E WI E E + + + L + + +R + + + R+ +
Sbjct: 850 ALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVN 909
Query: 854 ERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAET 913
+ +++ GH + +++ ++ LN R R+++ L + + Q Y + +E ++
Sbjct: 910 QIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKS 969
Query: 914 WIREKEPIVDNT-NYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAP 972
WIREK ++++T + G D AL +K DL + + L+ +A
Sbjct: 970 WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEA---------- 1019
Query: 973 VEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVR 1032
+++ + + QA++ +L+ L+ I+ W
Sbjct: 1020 -------EKLESEHPDQAQA----------ILSRLAEISDVW------------------ 1044
Query: 1033 RLAHDEFPMLPQRRREEPGNITQRQEQIEN--QYRSLLDRAEERRRRLLQRYNEFLLAYE 1090
+E + R G ++ Q+ + + ++S L R + A
Sbjct: 1045 ----EEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQT--------------AIA 1086
Query: 1091 AGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLL 1150
+ DM + E + T E ++ + D +++D ++RD+ +++ +G
Sbjct: 1087 SEDMPNTLTEAEKLLTQHE-----NIKNEIDNYEEDYQ----KMRDMG----EMVTQGQT 1133
Query: 1151 TPEGAQIRQEL---NSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALS 1207
+ +RQ L ++ W L ++ + ++ LL +HA + F R+ + + + L+
Sbjct: 1134 DAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1193
Query: 1208 AADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMEL 1267
+ + L +A ++ E F + +K+ + ET RL ++ +Q + +
Sbjct: 1194 HTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSI 1253
Query: 1268 NEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAED-LTGIEI 1326
++ + + L + + FL ++L WI+ M+++Q+++ D +
Sbjct: 1254 DDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINE--KMLTAQDMSYDEARNLHS 1311
Query: 1327 LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEK 1386
+HQ A++ + +E +LI +++KL + + LE +
Sbjct: 1312 KWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQT 1371
Query: 1387 RKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSS-LDSLEALMKKRDDLDKAITA 1445
+ + L + ++F +C ++ W+ E+ ++SDD L S+ L+KK+ L+ +
Sbjct: 1372 KAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEV 1431
Query: 1446 QEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQF 1505
++ +I +L+ A++L + E + +E+ ++ V ++ L L + + L + QF
Sbjct: 1432 RKKEIEELQSQAQAL-SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQF 1490
Query: 1506 YRDLEELEEWISEMLPTACDESY-KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNS 1564
RD+E+ W+ E +P A + + +Q K+QT E+ G ++ + +
Sbjct: 1491 NRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQN 1550
Query: 1565 LIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLS 1624
++ S+ + EA++++L LK+ W L+E T + ++L EA R Q++ + E W+S
Sbjct: 1551 IVTDSS-SLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMS 1609
Query: 1625 EAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQI 1684
E E + +++A+D SA ++LKKHQ+LE+ + + + L+ + L++ ++I
Sbjct: 1610 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669
Query: 1685 VKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRD 1744
++ V+K + +++LA KL E + LFQ +++DD E WI E+ + S + G+D
Sbjct: 1670 SMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQD 1729
Query: 1745 LQGVQNLLKKHKRLEGEL-VAHEPAIQNVLDMAEKL-----KDKAAVGQEEIQLRLAQFV 1798
+ V L ++ + + + + V +A++L D A + + + L
Sbjct: 1730 YEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLN----- 1784
Query: 1799 EHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLL 1858
E W L EL R L S E +F +A+E I +K+ + + G ++L
Sbjct: 1785 EAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHK-KLPEELGRDQNTVETLQ 1843
Query: 1859 MKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIA 1918
H E+D T+V+ + Q + + + +I + + E SL A
Sbjct: 1844 RMHTTFEHDIQALGTQVRQL--QEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACE 1901
Query: 1919 AWKLQLED-DYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASL 1977
+ +++L D F+ F+ D++ W+ D ++ D+ L+ + A +
Sbjct: 1902 SRRVRLVDTGDKFRFFSMVRDLM-LWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEI 1960
Query: 1978 QSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLP 2037
+ + + +L L++ +H S+ I+E+ L ++ +++++ R + L L
Sbjct: 1961 DA-RNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMID-KWEDRWEWLRLILE 2018
Query: 2038 LQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQA 2097
+ +F+ AS W E LS S++E+ +L K HE F S A
Sbjct: 2019 VH-------QFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDE 2071
Query: 2098 DFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFE 2157
F L L T+E+L E R Q+ ++E R+ + E
Sbjct: 2072 RFSALERL----------------TTLELL-----------EVRRQQEEEERKRRPPSPE 2104
Query: 2158 MCQEFEQNASTFLQW 2172
+ + A + QW
Sbjct: 2105 PSTKVSEEAESQQQW 2119
Score = 416 bits (1069), Expect = e-115
Identities = 342/1497 (22%), Positives = 676/1497 (45%), Gaps = 62/1497 (4%)
Query: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY-E 82
I++R + YQ + AER +LE+S L F + + WI EK IL+ Y +
Sbjct: 609 IRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 668
Query: 83 DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDL 142
D T++ KH++ E E+ +S + K E+ H E+ + I +R W
Sbjct: 669 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWAN 728
Query: 143 LLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFED 202
L +L+ + +L A Q+ + DI W+ D I +S ++G D T+ L KK +D
Sbjct: 729 LEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKD 788
Query: 203 FQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSN 262
E+ + +++ A+ +E H + P ++ + + + ++ + L R++AL +
Sbjct: 789 VAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQALQD 847
Query: 263 AANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKE 322
L + + WI EKE L + + L E + H + LE + + +V
Sbjct: 848 TLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAV 907
Query: 323 LCAKAEKLTLS-HPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDE 381
+ A +L S HPS+ +I+ ++ L + W R L + + L + + + +E
Sbjct: 908 VNQIARQLMHSGHPSE-KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNE 966
Query: 382 LSGWMNEKTAAI-NADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNAN 440
W+ EKT I + +L D+AG L + + ++ + + + + + L + +
Sbjct: 967 TKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEH 1026
Query: 441 HEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLE 500
+ + + ++ + + W + R + F RD + SW+SR + +
Sbjct: 1027 PDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA 1086
Query: 501 NEDLGNSLGSAEALLQKHEDFEEAFTAQEE---KIITVDKTATKLIGDDHYD--SENIKA 555
+ED+ N+L AE LL +HE+ + EE K+ + + T+ D Y + ++A
Sbjct: 1087 SEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQA 1146
Query: 556 IRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKK-KLADDEDYKDIQ 614
+ G + L + R+ LL +S Q+ D+ + ++N ++ LA E ++
Sbjct: 1147 LDTGW----NELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLE 1202
Query: 615 NLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLE 674
++ ++KQ+ F + N+ ++ + +TG+ ++ G+ SD + ++ + + E
Sbjct: 1203 GAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRE 1262
Query: 675 ATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLA-EVQNRLRKHGLLE 733
+ +L + +F + ++L W+ E +T++D A + ++ KH
Sbjct: 1263 TASELLMRLKDNRDLQKFLQDCQELSLWIN--EKMLTAQDMSYDEARNLHSKWLKHQAFM 1320
Query: 734 SAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLL 793
+ +A+ ++ +D + ++ + L +E L+ T+ ++L D
Sbjct: 1321 AELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDAN 1380
Query: 794 HLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEIT 853
+L + D + W+ E S GKDL + LL + +++ + + I+E+
Sbjct: 1381 KAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQ 1440
Query: 854 ERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAET 913
+ + +EG E + R+ + ME L R+ N L A+ + Q+ D+ +
Sbjct: 1441 SQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHN-LLASKEIHQFNRDVEDEIL 1499
Query: 914 WIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDL-------------------NSFGDS 954
W+ E+ P+ +T++G + + L+KK++ ++ +S S
Sbjct: 1500 WVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLS 1559
Query: 955 MKALRNQANACQQQQAAPVEGVAGEQRVM------ALYDFQARSPREVTMKKGDVLTLLS 1008
+A+R + +Q +E R + Y F A + E M + ++ +
Sbjct: 1560 AEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDA-AEAEAWMSEQELYMMSE 1618
Query: 1009 SINKDWWKVEA--ADHQGIVPAV-----YVRRLAHDEFPMLPQRRREEPGNITQRQEQIE 1061
KD + HQ + AV V +L+ ++ E I+ RQ +++
Sbjct: 1619 EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESE-RISMRQSKVD 1677
Query: 1062 NQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----AENTGVELDDVWELQ 1117
Y L D AEERR +L +R+ F L E D+ +WI E++ + G + + V LQ
Sbjct: 1678 KLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQ 1737
Query: 1118 KKFDEFQKDL-NTNEPRLRDINKVADDLLFEGLLTPEG-AQIRQELNSRWGSLQRLADEQ 1175
++F EF +D N + R+ +N +AD+L+ G A+ + LN W L L D +
Sbjct: 1738 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1797
Query: 1176 RQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPL 1235
Q+L +++ + F+ +A + +I+ K + L + G D +V+ LQR H FE D+ L
Sbjct: 1798 TQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQAL 1856
Query: 1236 GDKVTILGETAERLSESHP-DATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLF 1294
G +V L E A RL ++ D +D+Q+++ E+ EAW+ L + R+ L + + F
Sbjct: 1857 GTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRF 1916
Query: 1295 LSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAE 1354
S RDL W+ + + +QE D++ +E+L+ HQ +A+++A +F +
Sbjct: 1917 FSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKS 1976
Query: 1355 LIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVAR 1414
L+ H+AS EI++KL + +R ++ WE R + L LE+ F + E+W++ +
Sbjct: 1977 LLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQ 2036
Query: 1415 ENSLRSDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEE 1470
E L S + S+D +E L+K+ + +K+ + + + LE + + +EE
Sbjct: 2037 EPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEE 2093
Score = 326 bits (836), Expect = 1e-88
Identities = 355/1730 (20%), Positives = 734/1730 (42%), Gaps = 155/1730 (8%)
Query: 548 YDSENIKAIRDGLLARRDALREKAATR---RRLLKESLLLQKLYEDSDDLKNWINKKKKL 604
++ IKA+ D R+A+++K T+ L + S + LY D D + I + L
Sbjct: 40 FERSRIKALAD----EREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVL 95
Query: 605 ADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQ-EMIEGGHYASDNVTTRLS 663
+ + K + + R+ + +K L K Q +++ G ++++G H RL+
Sbjct: 96 SGERLPKPTKG-RMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNH--------RLT 146
Query: 664 EVASLWEELLEATKQKGTQLHEANQQLQFENNAEDL------------------QRWLED 705
+ +W +L Q + E N++ + +A L W +
Sbjct: 147 -LGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDG 205
Query: 706 VEWQVTSEDYGKGLAEVQNRLRK---HGLLESAVAARQDQVDILTDLAAYFEEIGHPDSK 762
+ + + L + ++L+K H L++A + + + L + HPD K
Sbjct: 206 MAFNALIHKHRPDLIDF-DKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEK 264
Query: 763 DIRARQESLVCRFEALKEPLATRKK--KLLD-LLHLQLICRDTE----DEEAWIQETEPS 815
I + F +K K+ K+LD + + + E D WI++T
Sbjct: 265 SIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIII 324
Query: 816 ATSTYLGKDLIASKKLL---NRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVAS 872
+ L+ ++ L N +R + + + TE+GN V ++ A+
Sbjct: 325 LNNRKFANSLVGVQQQLQAFNTYRTV--------EKPPKFTEKGNLEVLLFTIQSKMRAN 376
Query: 873 RVK-----------SLNQNMESLRARAARRQNDLEANVQFQQYLADLHEA--------ET 913
K +N+ E L R+ L + Q+ L L ET
Sbjct: 377 NQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRET 436
Query: 914 WIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPV 973
W+ E + +V N+G D A A KKHEA D+ ++ + ++A+ A + + +
Sbjct: 437 WLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDI 496
Query: 974 EGV-AGEQRVMALYDF-----QARSPREVTMKKG------DVLTLLSSINKDWWKVEAAD 1021
+ + A + V+ L+++ +AR R + M G ++L ++ +++ V + D
Sbjct: 497 KRITARKDNVIRLWEYLLELLRARRQR-LEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQD 555
Query: 1022 HQ----GIVPAVYVRRLAHDEFPMLPQRRRE------------------EPGNITQRQEQ 1059
+ G+ + L + + +R R +P I R
Sbjct: 556 YGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 615
Query: 1060 IENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----AENTGVELDDVWE 1115
+E Y+ L A ERR RL + + +E + WI+EK+ +++ G +L V
Sbjct: 616 MEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMR 675
Query: 1116 LQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE---LNSRWGSLQRLA 1172
L K F+ +++ K +D++ E E +IR+ + +W +L++L+
Sbjct: 676 LLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSE--KIRERIIYIREQWANLEQLS 733
Query: 1173 DEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDL 1232
+++ L A + F +ADD + + +S++D G D +S Q+L ++H+ ++
Sbjct: 734 AIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEI 793
Query: 1233 VPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFY 1292
+ L E A L + H + + D++ + + E ++++ T+ RK++L + Y
Sbjct: 794 ANYRPTLDTLHEQASALPQEHAE-SPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALY 852
Query: 1293 LFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFS 1352
S+A + WI +++ ++ E L +E++ R + +M +A + +
Sbjct: 853 KMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIA 912
Query: 1353 AELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMV 1412
+L+ SGH + EI+ + + + +++K L L +Q + C++ +SW+
Sbjct: 913 RQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIR 972
Query: 1413 ARENSLRS--DDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEE 1470
+ + S D + L + AL +K +++ + A E K++DL+ AE L ++ +
Sbjct: 973 EKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQA 1032
Query: 1471 IATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKD 1530
I +RL + D W+ +K L + LG+ + L+QF RDL++ + W+S E +
Sbjct: 1033 ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPN 1092
Query: 1531 A-TNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHW 1589
T ++ +H+ +E+D E + ++G ++ D ++++L+ L W
Sbjct: 1093 TLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG-EMVTQGQTDAQYMFLRQRLQALDTGW 1151
Query: 1590 DHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKH 1649
+ L + ++ L+++ Q+F + E +L+ E +LA + L A +KK
Sbjct: 1152 NELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQ 1211
Query: 1650 QLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKL 1709
+ M A E+ + + L+S G N D+I +K D+++ R +E A+ +L
Sbjct: 1212 EDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRL 1271
Query: 1710 KEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAI 1769
K+ L +F QD + WI EK++ Y + + + + KH+ EL +++ +
Sbjct: 1272 KDNRDLQKFLQDCQELSLWINEKMLTAQDMSYD-EARNLHSKWLKHQAFMAELASNKEWL 1330
Query: 1770 QNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829
+ +L + + ++ +L + WE L+ + + +L ++ + F Q+
Sbjct: 1331 DKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1390
Query: 1830 EEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKV 1889
+ + W++ + D G L + LL K + LEN V + ++ + +Q + +
Sbjct: 1391 DLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQ----AL 1446
Query: 1890 LQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKET 1949
QE E+ SK + K L + + K L +FN + W+ ++
Sbjct: 1447 SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMP 1506
Query: 1950 SLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQS-KAIEE 2008
+ +G +L L+ K TL +Q Q R+ +I + +++ + S +AI +
Sbjct: 1507 LATSTDHGHNLQTVQLLIKKNQTLQKEIQG-HQPRIDDIFERSQNIVTDSSSLSAEAIRQ 1565
Query: 2009 RYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKM--EENL 2066
R A L + W L+E + ++L E +A+ + + A + ++ M EE
Sbjct: 1566 RLADLKQLWGLLIEETEKRHRRLEE----AHRAQQYYFDAAEAEAWMSEQELYMMSEEKA 1621
Query: 2067 SEPVHCVSLNEIRQ-LQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVE 2125
+ VS+ + Q L++ ED+ ++ + L + + + A P S +
Sbjct: 1622 KDEQSAVSMLKKHQILEQAVEDYAETVHQ-------LSKTSRALVADSHPESERISMRQS 1674
Query: 2126 VLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILE 2175
+++ + L D+ EER +L + + F++ +E + QWI E
Sbjct: 1675 KVDKLYAGLKDLAEERRGKLDERH----RLFQLNREVDD----LEQWIAE 1716
Score = 324 bits (830), Expect = 7e-88
Identities = 335/1653 (20%), Positives = 685/1653 (41%), Gaps = 86/1653 (5%)
Query: 22 EEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIME-KVNILTDKS 80
+ I R+ V+ ++ E + R Q+LE + LQ ++ + W+ E KV +L+
Sbjct: 497 KRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556
Query: 81 YEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAH----EETKAHIEEL 136
+ ++ QKH +EA++ ++ + + + ++ T G + + + +
Sbjct: 557 GKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHM 616
Query: 137 RHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVL 196
+ L +L E+ +L + + ++ E A+ WI +KE I +S + G+D L
Sbjct: 617 EFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRL 676
Query: 197 HKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQR 256
K F+ E+ + G + + + E H I+ + + W L L+ R
Sbjct: 677 LSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIR 736
Query: 257 QKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVM 316
+K L A+ L +F+ D + W+ + +++S D G D +++ L HK + +A
Sbjct: 737 KKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANY 796
Query: 317 SDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFS 376
+ L +A L H +++P ++ + ++ + L R + LQ T ++
Sbjct: 797 RPTLDTLHEQASALPQEH-AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMF 855
Query: 377 SDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDL 436
S+ D W++EK +N ++P + EV+ R + + E+++ R ++ + L
Sbjct: 856 SEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQL 915
Query: 437 VNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQE 496
+++ H + E++ + + L+ W+ EL D + L ++ + + SW+ +
Sbjct: 916 MHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKT 975
Query: 497 AFLEN-EDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555
+E+ +DLGN L AL +K E A E K+ + K A KL +H D +A
Sbjct: 976 KVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL-ESEHPD--QAQA 1032
Query: 556 IRDGLLARRDALREKAAT---RRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD 612
I L D E T R L E+ LQ+ D DD ++W+++ + E D
Sbjct: 1033 ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASE---D 1089
Query: 613 IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVT--------TRLSE 664
+ N + +K + + K +++N ++ Q+M + G + T RL
Sbjct: 1090 MPNTLTEAEKLLTQHENI---KNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQA 1146
Query: 665 VASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQN 724
+ + W EL + + + L +++ QF + + + +L + E+ + + L +
Sbjct: 1147 LDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEA 1206
Query: 725 RLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLAT 784
++K + + A +++++ + + G+ +S I+ + +S+ R +E +
Sbjct: 1207 AIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASE 1266
Query: 785 RKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIAS 844
+L D LQ +D ++ WI E +A + K L +H+ + +AS
Sbjct: 1267 LLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWL-KHQAFMAELAS 1325
Query: 845 HEPRIQEITERGNKMVEEGHFAAEDVASRVKSLN---QNMESLRARAARRQNDLEANVQF 901
++ + +I + G +++ E V ++ L+ + +ES A+R D F
Sbjct: 1326 NKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELF 1385
Query: 902 QQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQ 961
Q ADL + W+ E + + +YG D + LLKK + + ++ L++Q
Sbjct: 1386 TQSCADL---DKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ 1442
Query: 962 ANACQQQQAAPVE----GVAGEQRVMALYD------FQARSPREVTMKKGDVLTLLSSIN 1011
A A Q+ + E + + + M L + + +E+ DV + +
Sbjct: 1443 AQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVG 1502
Query: 1012 KDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRS----- 1066
+ + DH + V + + Q + +I +R + I S
Sbjct: 1503 ERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA 1562
Query: 1067 --------------LLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----AENTGV 1108
L++ E+R RRL + + ++A + W+ E++ +E
Sbjct: 1563 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1622
Query: 1109 ELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQ-ELNSRWGS 1167
+ + KK ++ + + ++K + L+ + E +RQ +++ +
Sbjct: 1623 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAG 1682
Query: 1168 LQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEG 1227
L+ LA+E+R L H + +RE DD ++ I ++ + + G D V LQ R
Sbjct: 1683 LKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFRE 1742
Query: 1228 FERDLVPLG-DKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLN 1286
F RD +G ++V + A+ L S + K LNEAW DL R + L
Sbjct: 1743 FARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILA 1802
Query: 1287 EAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQ 1346
+ + + F A+++ I + +EL D +E L H D++A +
Sbjct: 1803 ASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVR 1861
Query: 1347 ALEDFSAEL--IDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNC 1404
L++ +A L +G A +++ + ++ + L+ +R +++D + + F
Sbjct: 1862 QLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR 1921
Query: 1405 DQVESWMVARENSLRSDDK-SSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIAD 1463
D + WM + + +K + S+E LM + I A+ T +SL+A
Sbjct: 1922 D-LMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR 1980
Query: 1464 EHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLP-T 1522
+HYA EEI +L ++ ++ K + + D L + QF RD E W+ P
Sbjct: 1981 KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2040
Query: 1523 ACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQL 1582
+ E + +++ +H+ F E+ + L E ++ +
Sbjct: 2041 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTL-----------ELLEVRR 2089
Query: 1583 EQLKEHWDHLLERTNDKGKKLNEASRQQRFNTS 1615
+Q +E K EA QQ+++TS
Sbjct: 2090 QQEEEERKRRPPSPEPSTKVSEEAESQQQWDTS 2122
Score = 322 bits (826), Expect = 2e-87
Identities = 304/1384 (21%), Positives = 590/1384 (42%), Gaps = 125/1384 (9%)
Query: 7 ETVVESSGPKVLETAE--EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64
+T+ E + E AE +++ R + RY+ E R Q L+D+ L +AD
Sbjct: 801 DTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADA 860
Query: 65 LGKWIMEKV----NILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFT 120
WI EK N+ + ED IQ ++ +SLE E+ ++ ++ + + +
Sbjct: 861 CELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPEMNNQASRVAVVNQIARQLMH 917
Query: 121 MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDK-EA 179
GH + +E KA ++L W EL K D LL AL Q Y EC + WI +K +
Sbjct: 918 SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 977
Query: 180 IATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPD-LPLIQSK 238
I ++ +LG D L +K + +LVA E ++ ++ + A E E HPD I S+
Sbjct: 978 IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEA-EKLESEHPDQAQAILSR 1036
Query: 239 QNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVA 298
E++ WE ++ R+ +L A+ LQ+F RD+ + W+ + + SED L
Sbjct: 1037 LAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTE 1096
Query: 299 SEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQ--IQEMKEDLVSSWEHIR 356
+E L H+ ++ + + +++ E +T +DA +++ + L + W +
Sbjct: 1097 AEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQ-TDAQYMFLRQRLQALDTGWNELH 1155
Query: 357 ALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHK 416
+ +R L ++ Y +F D + ++N + + E+PT + G E + + +
Sbjct: 1156 KMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFM 1215
Query: 417 HEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCL 476
+D+ +++ + ETG+ LV+ + SD ++EK++ +D+ E E + +
Sbjct: 1216 TTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNR 1275
Query: 477 DFHLFYRDSEQVDSWMSRQEAFLENEDLG-NSLGSAEALLQKHEDFEEAFTAQEEKIITV 535
D F +D +++ W++ E L +D+ + + + KH+ F + +E + +
Sbjct: 1276 DLQKFLQDCQELSLWIN--EKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKI 1333
Query: 536 DKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLK 595
+K +LI + +K GL + L T+ + L ++ + + DL
Sbjct: 1334 EKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLD 1393
Query: 596 NWINKKKKLADDEDY-KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYA 654
W++ + +DY KD+ ++ ++KQQ+ E ++ V K ++E +Q Q + + G +
Sbjct: 1394 KWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-S 1452
Query: 655 SDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSED 714
+D V ++ V + + ELLE ++ L + + QF + ED W+ + TS D
Sbjct: 1453 TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTD 1512
Query: 715 YGKGLAEVQNRLRKHGLLESAVAARQDQVD--------ILTDLAAYFEEIGHPDSKDIRA 766
+G L VQ ++K+ L+ + Q ++D I+TD ++ E IR
Sbjct: 1513 HGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA-------IRQ 1565
Query: 767 RQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLI 826
R L + L E R ++L + Q D + EAW+ E E S KD
Sbjct: 1566 RLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQ 1625
Query: 827 ASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRA 886
++ +L +H+++ + + + + ++++ +V + H +E ++ R +++ L+
Sbjct: 1626 SAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKD 1685
Query: 887 RAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLL 946
A R+ L+ + Q ++ + E WI E+E + + G D E L ++ F
Sbjct: 1686 LAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFAR 1745
Query: 947 DLNSFG----DSMKALRNQANACQQQQAAPV---------------EGVAGEQRVMA--- 984
D + G D++ L ++ AA + E + +++A
Sbjct: 1746 DTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASY 1805
Query: 985 ---------------LYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAV 1029
+ D + P E+ + V TL ++A Q
Sbjct: 1806 ELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQ------ 1859
Query: 1030 YVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAY 1089
VR+L D + ++ +I +R+ ++ ++SLLD E RR RL+ ++F
Sbjct: 1860 -VRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFS 1918
Query: 1090 EAGDMLEWI---------QEKKAENTGVEL------DDVWELQKKFDEFQKDLNTNEPRL 1134
D++ W+ QEK + + VEL E+ + D F + + L
Sbjct: 1919 MVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLL 1978
Query: 1135 RDINKVADDLLFEGL-LTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREAD 1193
+ ++++ + L LT + ++ + RW L+ + + V F R+A
Sbjct: 1979 ARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILE-----------VHQFSRDAS 2027
Query: 1194 DTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESH 1253
+ + + LS+ + G + V+ L +RHE FE+ ++ + L ERL+
Sbjct: 2028 VAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL----ERLT--- 2080
Query: 1254 PDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVS 1313
+EL E Q ++RK + +A Q W +S G VS
Sbjct: 2081 ----------TLELLEVRR--QQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVS 2128
Query: 1314 SQEL 1317
L
Sbjct: 2129 QNGL 2132
Score = 247 bits (631), Expect = 9e-65
Identities = 282/1354 (20%), Positives = 559/1354 (41%), Gaps = 87/1354 (6%)
Query: 931 EEAAGALLKKHEAFLLDLNS--FGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDF 988
E A LL+ E ++ LN+ F +S+ ++ Q A + E+ + + F
Sbjct: 308 ESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLF 367
Query: 989 QARSPREVTMKKGDVLT---LLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQR 1045
+S +K + L+S INK W ++E A+H+ R LA
Sbjct: 368 TIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHE--------RELA---------- 409
Query: 1046 RREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAEN 1105
N RQE++E R +A R L + N+ L++ +N
Sbjct: 410 ----LRNELIRQEKLEQLARRFDRKAAMRETWLSE--NQRLVS--------------QDN 449
Query: 1106 TGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSR- 1164
G +L V KK + + D+ E R++ + VA +L E + R++ R
Sbjct: 450 FGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRL 509
Query: 1165 WGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRR 1224
W L L +RQ L ++ +E + +++ + + D G L V+ L ++
Sbjct: 510 WEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQK 569
Query: 1225 HEGFERDLVPLGDKVTILGETAERLS---ESHPDATEDLQRQKM-ELNEAWEDLQGRTKD 1280
H E D+ ++V + +A++ + E + + R ++ + +++L +
Sbjct: 570 HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAE 629
Query: 1281 RKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEA 1340
R+ L E+++ + F + + + WI ++SS + +DLT + LL +H+ +M
Sbjct: 630 RRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSG 689
Query: 1341 EAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMF 1400
+ F+ ++I H S +I +++ ++ + +LE+ RKK L++ L F
Sbjct: 690 RSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQF 749
Query: 1401 QGNCDQVESWMVARENSLRSDDKSSLD-SLEALMKKRDDLDKAITAQEGKITDLEHFAES 1459
Q + D +++WM+ + S D + S ++L+KK D+ + I A D H S
Sbjct: 750 QADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEI-ANYRPTLDTLHEQAS 808
Query: 1460 LIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISE- 1518
+ EH ++ RL + +R+K + + L D L + + + + E WI E
Sbjct: 809 ALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEK 868
Query: 1519 ---MLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNE 1575
+ E +D IQ ++ ++ E++ ++ +V V + L+ +E
Sbjct: 869 EQWLNNMQIPEKLEDLEVIQHRF---ESLEPEMNNQASRVAVVNQIARQLMHSG--HPSE 923
Query: 1576 EAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSE-AETLLAMKD 1634
+ +K Q ++L W E + K L A Q ++ + + W+ E + + + +D
Sbjct: 924 KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 983
Query: 1635 QARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKR 1694
DLA L +K +ER+++A E L DL AE L S I+ + ++
Sbjct: 984 LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1043
Query: 1695 FLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKK 1754
+ ++ L EA L QF +DLDD +SW+ ++S+D L + LL +
Sbjct: 1044 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQ 1103
Query: 1755 HKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEE-IQLRLAQFVEHWEKLKELAKARGL 1813
H+ ++ E+ +E Q + DM E + Q ++ RL W +L ++ + R
Sbjct: 1104 HENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQN 1163
Query: 1814 KLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHET 1873
L +S Y QF+++ ++ EA++N + + + TL ++ + K E +E
Sbjct: 1164 LLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEE 1223
Query: 1874 RVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEF 1933
++ V G + V + I K+++++++ + + ++L+D+ Q+F
Sbjct: 1224 KINAVVETGRRL---VSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKF 1280
Query: 1934 NWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKD 1993
+ WI +K + + + + + + + K A L S +E L +I
Sbjct: 1281 LQDCQELSLWINEKMLTAQ-DMSYDEARNLHSKWLKHQAFMAELAS-NKEWLDKIEKEGM 1338
Query: 1994 KLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKAS 2053
+LIS + ++E+ L K WE L + Q+L + KAE F +
Sbjct: 1339 QLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFD----ANKAE----LFTQSCA 1390
Query: 2054 ALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALG 2113
L+ W +E + + L + L K + + + + + L Q + G
Sbjct: 1391 DLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEG 1450
Query: 2114 VPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173
+ + V + + L + E + L +E Q F ++ + W+
Sbjct: 1451 KSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQ---------FNRDVEDEILWV 1501
Query: 2174 LETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL-EDALILD-- 2230
E T++ ++ N+ QKEIQ + ++ I + N+ D+ L
Sbjct: 1502 GERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE 1561
Query: 2231 -IKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAK 2263
I+ L Q W L + + LE+ +A+
Sbjct: 1562 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQ 1595
Score = 42.0 bits (97), Expect = 0.007
Identities = 30/142 (21%), Positives = 63/142 (44%), Gaps = 3/142 (2%)
Query: 2127 LERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLL 2186
+ + W+ L ERE L+ E RQ K ++ + F++ A+ W+ E + +
Sbjct: 392 INKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFG 451
Query: 2187 KETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTI---GLAQQWD 2243
+ +E+ + ++ + +I A + ++ +V + LE DIK T + + W+
Sbjct: 452 FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWE 511
Query: 2244 QLYQLGLRMQHNLEQQIQAKDI 2265
L +L + LE + + I
Sbjct: 512 YLLELLRARRQRLEMNLGLQKI 533
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 483 bits (1244), Expect = e-136
Identities = 361/1445 (24%), Positives = 653/1445 (45%), Gaps = 97/1445 (6%)
Query: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKS 80
A + R E+ +++ + ER Q+L + L F+ DA+D+ W+++ + +++
Sbjct: 715 ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPE 774
Query: 81 Y-EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGH--SAHEETKAHIEELR 137
D + Q ++H++LE E+++ + L RE+ + S E + + L
Sbjct: 775 LGHDEFSTQALARQHRALEEEIRSHRPTLDAL---REQAAALPPTLSRTPEVQGRVPTLE 831
Query: 138 HLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLH 197
++ L E+ L AL + E W+ +KE + L E E EV+
Sbjct: 832 RHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQ 891
Query: 198 KKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQ 257
++FE + E+ ++ VN A + + N P I + Q ++N W++ R LA ++
Sbjct: 892 QRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKK 951
Query: 258 KALSNAANLQRFKRDVTEAIQWIKEKEPVLTS-EDYGKDLVASEGLFHSHKGLERNLAVM 316
AL++A ++Q + + TE W++EK V+ S + G DL L G ER+L +
Sbjct: 952 AALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAI 1011
Query: 317 SDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFS 376
+ +V EL +A L HP+ A I ++ + WE +RA R E L F
Sbjct: 1012 AARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFL 1071
Query: 377 SDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDL 436
D+ W+ A+ ++E P + E LL +H + E++ + G+++
Sbjct: 1072 RSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEV 1131
Query: 437 VNANHEASDE-VREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQ 495
+ +R+++E L W L +W+ R + Q F F RD+ Q + +S Q
Sbjct: 1132 TRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQ 1191
Query: 496 EAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555
E L + ++ +L +A+A ++K EDF A E+I + + +L+ + + ++ I+
Sbjct: 1192 EYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251
Query: 556 IRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQN 615
D + R ++ A L+++ Q +D +LK WI++K A D Y + +N
Sbjct: 1252 KADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARN 1311
Query: 616 LKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEA 675
L ++ QK Q F ELA NK L+ + K G+E+ V+ +L ++ W+EL
Sbjct: 1312 LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETT 1371
Query: 676 TKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESA 735
T+ K L +AN+ F + L+ WLE ++ Q+ S+DYGK L V L+K +LE
Sbjct: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWE 1431
Query: 736 VAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHL 795
+A R+ +V+ + A + + ++ ++ +F AL +P+ R ++L
Sbjct: 1432 MAVREKEVEAIQAQAKALAQ-EDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQ 1490
Query: 796 QLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITER 855
RD EDE W+ E P A+S GKDL + + L+ +++ + + I HEPRI ++ ER
Sbjct: 1491 HQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRER 1550
Query: 856 GNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWI 915
+ A + L + + L R LE ++ QQ+ D EAE W+
Sbjct: 1551 QRAL------GAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWM 1604
Query: 916 REKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEG 975
E+E + DE +A A +KKH+ +AL + A Q A+ +
Sbjct: 1605 GEQELHMMGQEKAKDELSAQAEVKKHQVL----------EQALADYAQTIHQLAASSQD- 1653
Query: 976 VAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLA 1035
+ D + +++++ V L + G+ RR
Sbjct: 1654 ---------MIDHEHPESTRISIRQAQVDKL---------------YAGLKELAGERRER 1689
Query: 1036 HDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEE--RRRRLLQRYNEFLLAYEAGD 1093
E L Q RRE LD E+ + R ++ +E YE
Sbjct: 1690 LQEHLRLCQLRRE-------------------LDDLEQWIQEREVVAASHELGQDYEHVT 1730
Query: 1094 MLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNT-NEPRLRDINKVADDLLFEG-LLT 1151
ML + KF EF +D +T + R+ N +A+ L+ G
Sbjct: 1731 ML---------------------RDKFREFSRDTSTIGQERVDSANALANGLIAGGHAAR 1769
Query: 1152 PEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADP 1211
A+ + LN W L L D + Q+L +A+ ++ F A +++ K Q L
Sbjct: 1770 ATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDG-T 1828
Query: 1212 GSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHP-DATEDLQRQKMELNEA 1270
G DL + +ALQRRH +E D+ L +V + + RL +++ D E++ R + EA
Sbjct: 1829 GRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEA 1888
Query: 1271 WEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLER 1330
W LQG + R++ L + + F R+L W+ + + +QE D++ +++++
Sbjct: 1889 WAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKN 1948
Query: 1331 HQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKI 1390
Q +A++EA A F + D EL+ H+A+ EI +KL ++ R + + W+++
Sbjct: 1949 QQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDW 2008
Query: 1391 LDQCLELQMFQGNCDQVESWMVARENSLRSDDKS-SLDSLEALMKKRDDLDKAITAQEGK 1449
L LE+ +F + E+W+ ++E +RS + ++D +E+L+K+ + K+ A E +
Sbjct: 2009 LQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEER 2068
Query: 1450 ITDLE 1454
LE
Sbjct: 2069 FCALE 2073
Score = 461 bits (1186), Expect = e-129
Identities = 417/1643 (25%), Positives = 736/1643 (44%), Gaps = 103/1643 (6%)
Query: 518 HEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENI---KAIRDGLLARRDALREKAATR 574
H + + AF E+++ + + D D ++I A ++ AL +
Sbjct: 234 HYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRI 293
Query: 575 RRLLKESLLLQKLYED----SDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQ-QVFEKE 629
++L ++ ++L E + +L WI + +D + + N S VQ Q Q F
Sbjct: 294 GKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLND---RQLANSLSGVQNQLQSFNSY 350
Query: 630 LAVNKT-------QLENIQKTGQEMIEGGHYA--SDNVTTRLSEVASLWEELLEATKQKG 680
V K LE + T Q + + + +S++ WE L +A ++
Sbjct: 351 RTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERE 410
Query: 681 TQLH------EANQQL--QFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLL 732
L E +QL +F+ A + WL + + V+ +++G LA V+ +RKH +
Sbjct: 411 LALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAI 470
Query: 733 ESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDL 792
E+ + A +V + +AA + D K I ARQ ++ ++ L++ +A R+++LL
Sbjct: 471 ETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLN 530
Query: 793 LHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEI 852
L LQ + +D W++E + S LG+ L + LL H ++ +IA R++ +
Sbjct: 531 LELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAV 590
Query: 853 TERGNKMVEEGH----FAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADL 908
+ + G + V+ RV L Q+ E+L AA R+ LE + + ++L ++
Sbjct: 591 SASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEV 650
Query: 909 HEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQ------- 961
EAE W+RE++ ++ + + G D A LL KH A +++ +K Q
Sbjct: 651 GEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAE 710
Query: 962 ---------ANACQ-QQQAAPVEGVAGEQ-----RVMALYDFQARSPREVTMKKGDVLTL 1006
A A + Q Q +E +A E+ + +LY FQA + ++ D L L
Sbjct: 711 GHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADA-NDMEAWLVDALRL 769
Query: 1007 LSS--INKDWWKVEAA--DHQGIVPAVYVRRLAHD----EFPMLPQRRREEPGNITQRQE 1058
+SS + D + +A H+ + + R D + LP P + R
Sbjct: 770 VSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTP-EVQGRVP 828
Query: 1059 QIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGV----ELDDVW 1114
+E Y L RA ER R L + + EAG W++EK+ G+ L+D+
Sbjct: 829 TLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLE 888
Query: 1115 ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEG----AQIRQELNSRWGSLQR 1170
+Q++F+ + ++NT ++ +N +A+ LL P G +++LN RW +R
Sbjct: 889 VVQQRFETLEPEMNTLAAQITAVNDIAEQLL---KANPPGKDRIVNTQEQLNHRWQQFRR 945
Query: 1171 LADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADP-GSDLFSVQALQRRHEGFE 1229
LAD ++ L SA +++ +H E +T+ + +K + + + G+DL V ALQR+ G E
Sbjct: 946 LADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTE 1005
Query: 1230 RDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQ 1289
RDL + +V L A L+ HP + + E+ WEDL+ + R+ESL EA+
Sbjct: 1006 RDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR 1065
Query: 1290 KFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALE 1349
+ FL D Q W+ V+S+E L E LL +H R ++E + L
Sbjct: 1066 RLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR 1125
Query: 1350 DFSAELIDSGHHASPE---IEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQ 1406
E+ + A P+ + ++L+A+ ++L + WE R+ L Q Q F + Q
Sbjct: 1126 ALGEEV--TRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQ 1183
Query: 1407 VESWMVARENSL-RSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEH 1465
E + ++E L ++ +L + +A +KK +D + A +I L L+++ +
Sbjct: 1184 AEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGN 1243
Query: 1466 YAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACD 1525
++I + + R K + +L D + F +D EL+ WI E + TA D
Sbjct: 1244 IHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQD 1303
Query: 1526 ESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSL-IECSACDGNEEAMKEQLEQ 1584
SY +A N+ K+ KHQ F E+ + + V G L +E + + E+L
Sbjct: 1304 VSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPEL---KALVSEKLRD 1360
Query: 1585 LKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGN 1644
L WD L T K + L +A+R + F S E WL + L D +DL S
Sbjct: 1361 LHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNI 1420
Query: 1645 LLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAA 1704
LLKK Q+LE EM RE ++ + A+ L ++ + V ++F + +
Sbjct: 1421 LLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQ-GAGEVERTSRAVEEKFRALCQPMRE 1479
Query: 1705 HHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVA 1764
+L+ + QF +D++DE W+ E+L SS ++G+DL VQ L+KK++ L+ E+
Sbjct: 1480 RCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQG 1539
Query: 1765 HEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQF 1824
HEP I ++ + L AA G E LA+ E W++L + RG +LE++L QF
Sbjct: 1540 HEPRIADLRERQRAL-GAAAAGPE-----LAELQEMWKRLGHELELRGKRLEDALRAQQF 1593
Query: 1825 MQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGED 1884
++A E EAW+ E+ + + + Q+ + KH+ LE A + + + A +D
Sbjct: 1594 YRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQD 1653
Query: 1885 ILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWI 1944
+++ E ++ IS + +++ L + + +L++ + + D +E WI
Sbjct: 1654 MID---HEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI 1710
Query: 1945 ADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSK 2004
++E ++ G D L K + QER+ L + LI+ H
Sbjct: 1711 QEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA 1770
Query: 2005 AIEERYAALLKRWEQLLEASAVHRQKL---LEKQLPLQKAEDLFVEFAHKASALNNWCEK 2061
+ E +L + W LLE Q L E Q L A HK L + +
Sbjct: 1771 TVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGR 1830
Query: 2062 MEENLSEPV---HCVSLNEIRQL 2081
+ N +E + HC ++I+ L
Sbjct: 1831 -DLNAAEALQRRHCAYEHDIQAL 1852
Score = 344 bits (883), Expect = 5e-94
Identities = 356/1726 (20%), Positives = 704/1726 (40%), Gaps = 90/1726 (5%)
Query: 5 PKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64
P+E + S K E E+ + R+ L +E++ + + F R A
Sbjct: 386 PREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAAR---------FDRKAAM 436
Query: 65 LGKWIMEKVNILTDKSYE-DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGH 123
W+ E +++ ++ + ++ +KH+++E ++ S + ++ E +
Sbjct: 437 RETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERY 496
Query: 124 SAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATS 183
+ A + LWD L ++ + ++LL L+ Q+ Q+ +++W+ + + S
Sbjct: 497 HDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQS 556
Query: 184 VELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVN----QYANECAEENHPDLPLIQSKQ 239
+LG E L + E + ++ + RV V+ ++ N E D L+ +
Sbjct: 557 QDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERV 616
Query: 240 NEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVAS 299
++ ++E L LA R+ L + L RF +V EA W++E++ +L S D G+DL +
Sbjct: 617 AKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGA 676
Query: 300 EGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALA 359
L + H L ++ +K + ++L A Q +L + WE + ALA
Sbjct: 677 LRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALA 736
Query: 360 TSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEI 419
R ++L ++F +D +++ W+ + +++ EL D + L +H+ + EI
Sbjct: 737 EERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEI 796
Query: 420 DSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFH 479
S+ + E L + EV+ ++ L+ ++ L ER R E L +
Sbjct: 797 RSHRPTLDALREQAAAL-PPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALY 855
Query: 480 LFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTA 539
++ W+ +E +L L L E + Q+ E E +I V+ A
Sbjct: 856 TMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIA 915
Query: 540 TKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWIN 599
+L+ + + I ++ L R R A ++ L +L +Q + + + + W+
Sbjct: 916 EQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMR 975
Query: 600 KKKKLADDED--YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDN 657
+K K+ + D+ + + +K E++L ++ + + + G +
Sbjct: 976 EKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVA 1035
Query: 658 VTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGK 717
+ RL EV + WE+L +++ L EA + F + +D Q WL + V SE+
Sbjct: 1036 INARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPA 1095
Query: 718 GLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEI----GHPDSKDIRARQESLVC 773
L E + L +H L V Q + + L A EE+ P +R R E+L
Sbjct: 1096 TLPEAEALLAQHAALRGEVERAQSE---YSRLRALGEEVTRDQADPQCLFLRQRLEALGT 1152
Query: 774 RFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLN 833
+E L +R+ +L Q RD E + E + T + L A+ +
Sbjct: 1153 GWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIK 1212
Query: 834 RHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQN 893
+ + + ++ RI + E G ++V EG+ A+ + + S+ + + + A +
Sbjct: 1213 KLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLG 1272
Query: 894 DLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLK--KHEAFLLDLNSF 951
L N + Q +L D HE + WI EK + +Y +EA K KH+AF+ +L +
Sbjct: 1273 RLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSY---DEARNLHTKWQKHQAFMAELAAN 1329
Query: 952 GDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSIN 1011
D + + + ++ ++ + E+ L D R T + +L +
Sbjct: 1330 KDWLDKVDKEGRELTLEK-PELKALVSEK----LRDLHRRWDELETTTQAKARSLFDANR 1384
Query: 1012 KDWWKVEAADHQGIVPAV--------YVRRLAHDEFPMLPQRRREEPGNITQRQ-EQIEN 1062
+ + + + ++ Y + L + Q+ E + +++ E I+
Sbjct: 1385 AELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQA 1444
Query: 1063 QYRSLLDR-------------AEERRRRLLQRYNEFLLAYEAG-----------DMLEWI 1098
Q ++L EE+ R L Q E +A D + W+
Sbjct: 1445 QAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWV 1504
Query: 1099 QEK----KAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEG 1154
E+ + G +L V L KK QK++ +EPR+ D+ + L PE
Sbjct: 1505 TERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRE-RQRALGAAAAGPEL 1563
Query: 1155 AQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSD 1214
A EL W L + + + L A + F+R+A + + + ++ + + D
Sbjct: 1564 A----ELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKD 1619
Query: 1215 LFSVQALQRRHEGFERDLVPLGDKV-TILGETAERLSESHPDATEDLQRQKMELNEAWED 1273
S QA ++H+ E+ L + + + + + HP++T RQ ++++ +
Sbjct: 1620 ELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQ-AQVDKLYAG 1678
Query: 1274 LQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQE 1333
L+ +R+E L E + + DL+ WI + +S EL +D + +L ++ +E
Sbjct: 1679 LKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFRE 1738
Query: 1334 HRADMEA-EAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILD 1392
D + + LI GH A + + ++ DL + + R ++L
Sbjct: 1739 FSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLA 1798
Query: 1393 QCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLD---KAITAQEGK 1449
ELQ F Q + + ++ L L++ EAL ++ + +A++ Q +
Sbjct: 1799 AAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQ 1858
Query: 1450 ITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDL 1509
+ D H + A + EEI +Q V + W L+ R L D + +F++ +
Sbjct: 1859 VQDDGHRLQKAYAGD--KAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAV 1916
Query: 1510 EELEEWISEM-LPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIEC 1568
EL W+ E+ L E +D ++ Q E++ R+++ I++G L+
Sbjct: 1917 RELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLAR 1976
Query: 1569 SACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAET 1628
S E + E+L QL+ E+ +K L F E WL E
Sbjct: 1977 SHYAAEE--ISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEP 2034
Query: 1629 LLAMKDQARDLASAGNLLKKHQLLEREMLARED---ALKDLNTLAE 1671
L+ + + +L+K+H+ ++ +A E+ AL+ L L E
Sbjct: 2035 LVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEE 2080
Score = 324 bits (831), Expect = 6e-88
Identities = 362/1761 (20%), Positives = 724/1761 (41%), Gaps = 122/1761 (6%)
Query: 491 WMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEA-----FTAQEEKIITVDKTATKLIGD 545
W+ + L + L NSL + LQ + FT + + + +KL +
Sbjct: 320 WIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRAN 379
Query: 546 DH--YDSENIKAIRDGLLARRDALREKAATRRRL-LKESLLLQKLYED--------SDDL 594
+ Y + I D + + EKA R L L+ L+ Q+ E +
Sbjct: 380 NQKVYTPREGRLISD--INKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMR 437
Query: 595 KNWINKKKKLADDEDYK-DIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHY 653
+ W+++ ++L +++ ++ +++ V+K + E ++ +++ + E+ ++
Sbjct: 438 ETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYH 497
Query: 654 ASDNVTTRLSEVASLWE---ELLEATKQK---GTQLHEANQQLQFENNAEDLQRWLEDVE 707
+ R VA LW+ +++ A +++ +L + Q L + L W+E+++
Sbjct: 498 DIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLY------LMDWMEEMK 551
Query: 708 WQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYF----EEIGHPDSKD 763
++ S+D G+ LA V++ L+ H L+E+ +A + ++V ++ A F +E D +
Sbjct: 552 GRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQL 611
Query: 764 IRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGK 823
+ R L +EAL E A R+ +L + L + + EAW++E + S G+
Sbjct: 612 VSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGR 671
Query: 824 DLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMES 883
DL + +LLN+H + ++ ++ E+G ++V EGH A ++R L E
Sbjct: 672 DLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWER 731
Query: 884 LRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEA 943
L A A R L Q+ AD ++ E W+ + +V + G DE + AL ++H A
Sbjct: 732 LEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRA 791
Query: 944 FLLDLNSFGDSMKALRNQANAC---------------------QQQQAAPVEGVAGEQRV 982
++ S ++ ALR QA A ++ QA E +
Sbjct: 792 LEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAA 851
Query: 983 MALYDFQARS--------PREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRL 1034
+ALY + + +E + + L + + E + + A + +
Sbjct: 852 LALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAV 911
Query: 1035 AHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDM 1094
+D L + I QEQ+ ++++ A+ ++ L + E +
Sbjct: 912 -NDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTET 970
Query: 1095 LEWIQEK-----KAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGL 1149
W++EK + G +L V LQ+K ++DL R+ ++ + A+ L
Sbjct: 971 QAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHP 1030
Query: 1150 LTPEGAQIR-QELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSA 1208
R +E+ + W L+ + + LG A ++ F R DD + + + A+++
Sbjct: 1031 AQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVAS 1090
Query: 1209 ADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKME-L 1267
+ + L +AL +H ++ + + L E ++ D RQ++E L
Sbjct: 1091 EEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEAL 1150
Query: 1268 NEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEIL 1327
WE+L + R+ L +A F FL AR + +SS ++S E+ L +
Sbjct: 1151 GTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAA 1210
Query: 1328 LERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKR 1387
+++ ++ + M+A L + +L+ G+ + +I +K +++ + A ++
Sbjct: 1211 IKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQF 1270
Query: 1388 KKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQE 1447
L E Q F +C +++ W+ + + + +L +K + A +
Sbjct: 1271 LGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANK 1330
Query: 1448 GKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYR 1507
+ ++ L ++ K ++ +L+ + RW L+ + L D + F +
Sbjct: 1331 DWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQ 1390
Query: 1508 DLEELEEWISEMLPTACDESY-KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLI 1566
LE W+ + + Y KD T++ K Q E+ R ++V + +L
Sbjct: 1391 SCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALA 1450
Query: 1567 ECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEA 1626
+ G E +E E + L + ++ ++L + Q +F+ + D W++E
Sbjct: 1451 QEDQGAGEVERTSRAVE---EKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTER 1507
Query: 1627 ETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVK 1686
+ + + +DL S L+KK+Q L++E+ E + DL E + G +
Sbjct: 1508 LPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLR---ERQRALGAAAAGPELA 1564
Query: 1687 KKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQ 1746
+ + KR + EL ++L++A QF++D + E+W+ E+ + + Q+ +D
Sbjct: 1565 ELQEMWKRLGHELELRG---KRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDEL 1621
Query: 1747 GVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKE 1806
Q +KKH+ LE L + I + ++ + D I +R AQ + + LKE
Sbjct: 1622 SAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKE 1681
Query: 1807 LAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALEN 1866
LA R +L+E L Q + ++ E WI E+ +A + G L K
Sbjct: 1682 LAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSR 1741
Query: 1867 DFA-VHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLE 1925
D + + + RV + A + + + ++ ++LNE L + + L
Sbjct: 1742 DTSTIGQERVDSANALANGL---IAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLA 1798
Query: 1926 DDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERL 1985
Y Q F A A + K+ L +G G DL L + + +Q+ + +
Sbjct: 1799 AAYELQRFLHGARQALARVQHKQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQALSPQ-V 1856
Query: 1986 PEITDLKDKLISA-QHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDL 2044
++ D +L A ++++ I A+ + W QL +SA RQ LL+ D
Sbjct: 1857 QQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLD-------TTDK 1909
Query: 2045 FVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLE 2104
F F L W +++ LQ D ++ ++ A K
Sbjct: 1910 F-RFFKAVRELMLWMDEV-----------------NLQMDAQERPRDVSSADLVIKNQQG 1951
Query: 2105 LDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQ 2164
+ +I+A S + E+L R+ H + EE ++L + +AR+ + E QE
Sbjct: 1952 IKAEIEARADRFSSCIDMGKELLARS--HYA--AEEISEKLSQLQARRQETAEKWQE--- 2004
Query: 2165 NASTFLQWILETRAYFLDGSL 2185
+LQ +LE + D +
Sbjct: 2005 -KMDWLQLVLEVLVFGRDAGM 2024
Score = 238 bits (606), Expect = 7e-62
Identities = 222/960 (23%), Positives = 416/960 (43%), Gaps = 48/960 (5%)
Query: 1159 QELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSV 1218
+ L + W L R+ + ++ L AH + F R+A + + + LS + L +
Sbjct: 1148 EALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAA 1207
Query: 1219 QALQRRHEGFERDLVPLGDKVTILGETAERLSES---HPDA----TEDLQRQKMELNEAW 1271
A ++ E F + G+++ L E +L H D + ++R+ + +A
Sbjct: 1208 DAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAA 1267
Query: 1272 EDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAED-LTGIEILLER 1330
+ GR +D +E + FL +L+ WI M+++Q+++ D + ++
Sbjct: 1268 QQFLGRLRDNREQQH-------FLQDCHELKLWIDE--KMLTAQDVSYDEARNLHTKWQK 1318
Query: 1331 HQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKI 1390
HQ A++ A ++ EL + +KL+ + D+LE + + +
Sbjct: 1319 HQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARS 1378
Query: 1391 LDQCLELQMFQGNCDQVESWMVARENSLRSDDKSS-LDSLEALMKKRDDLDKAITAQEGK 1449
L ++F +C +ESW+ + + L SDD L S+ L+KK+ L+ + +E +
Sbjct: 1379 LFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKE 1438
Query: 1450 ITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDL 1509
+ ++ A++L A E E+ + V ++++AL + + +L QF+RD+
Sbjct: 1439 VEAIQAQAKAL-AQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDV 1497
Query: 1510 EELEEWISEMLPTACD-ESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIEC 1568
E+ W++E LP A E KD ++Q K+QT E+ G ++ + +L
Sbjct: 1498 EDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRAL--- 1554
Query: 1569 SACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAET 1628
A +L +L+E W L +GK+L +A R Q+F + E W+ E E
Sbjct: 1555 -----GAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQEL 1609
Query: 1629 LLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688
+ +++A+D SA +KKHQ+LE+ + + L ++D++ +I ++
Sbjct: 1610 HMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQ 1669
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748
V+K + ++ELA E+L+E L Q ++LDD E WI+E+ + +S + G+D + V
Sbjct: 1670 AQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHV 1729
Query: 1749 QNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFV----EHWEKL 1804
L K + + Q +D A L + G + +A++ E W L
Sbjct: 1730 TMLRDKFREFSRDT---STIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADL 1786
Query: 1805 KELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEAL 1864
EL RG L + E +F+ A + A + K G G L A ++L +H A
Sbjct: 1787 LELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDG-TGRDLNAAEALQRRHCAY 1845
Query: 1865 ENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQL 1924
E+D +VQ V G + ++++ EI ++A+ E L + AA + L
Sbjct: 1846 EHDIQALSPQVQQVQDDGHRLQKAYAGDKAE--EIGRHMQAVAEAWAQLQGSSAARRQLL 1903
Query: 1925 EDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQER 1984
D F + W+ + + D+ ++ Q + A +++ + +R
Sbjct: 1904 LDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEA-RADR 1962
Query: 1985 LPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDL 2044
D+ +L++ H ++ I E+ + L R ++ E K EK LQ ++
Sbjct: 1963 FSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAE-------KWQEKMDWLQLVLEV 2015
Query: 2045 FVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLE 2104
V F A W E + +++E+ L K HE F S + F C LE
Sbjct: 2016 LV-FGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERF-CALE 2073
Score = 195 bits (496), Expect = 4e-49
Identities = 293/1416 (20%), Positives = 591/1416 (41%), Gaps = 154/1416 (10%)
Query: 931 EEAAGALLKKHEAFLLDLNS--FGDSMKALRNQA---NACQQQQAAPVEGVAGEQRVMAL 985
E A LL+ E ++ LN +S+ ++NQ N+ + + P G V+ L
Sbjct: 311 ESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVL-L 369
Query: 986 YDFQ----ARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPM 1041
+ Q A + + T ++G L+S INK W ++E A+H+ R LA
Sbjct: 370 FTIQSKLRANNQKVYTPREG---RLISDINKAWERLEKAEHE--------RELA------ 412
Query: 1042 LPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEK 1101
R E RQE++E Q + DR R L N+ L++ +
Sbjct: 413 ----LRTE----LIRQEKLE-QLAARFDRKAAMRETWLSE-NQRLVSQD----------- 451
Query: 1102 KAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQEL 1161
N G+EL V +K + + D+ R++ ++ VA +L E + RQ
Sbjct: 452 ---NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHN 508
Query: 1162 NSR-WGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQA 1220
+R W L+++ +R+ L ++ ++ + +E+ L + D G L V+
Sbjct: 509 VARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVED 568
Query: 1221 LQRRHEGFERDLVPLGDKVTILGETAERL----SESHPDATEDLQRQKMELNEAWEDLQG 1276
L + HE E D+ ++V + +A R E P + + + +L +++E L
Sbjct: 569 LLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCE 628
Query: 1277 RTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRA 1336
R+ L E+++ + FL + + + W+ +++S + DLTG LL +H R
Sbjct: 629 LAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRG 688
Query: 1337 DMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLE 1396
+M + + +L+ GH + + + ++ + + LE E+R + L Q
Sbjct: 689 EMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAAS 748
Query: 1397 LQMFQGNCDQVESWMVARENSLRSDDKSSLD-SLEALMKKRDDLDKAITAQEGKITDLEH 1455
L FQ + + +E+W+V + S + + S +AL ++ L++ I + + L
Sbjct: 749 LYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALRE 808
Query: 1456 FAESL---------------IADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYA 1500
A +L + HY EE+ R +R +AL+A L T L +
Sbjct: 809 QAAALPPTLSRTPEVQGRVPTLERHY--EELQARAG---ERARALEAALA-LYTMLSEAG 862
Query: 1501 NLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVIN 1560
+ +EE E+W++ + A E +D +Q+++ +T E++ + Q+ V +
Sbjct: 863 ACGLW---VEEKEQWLNGL---ALPERLEDLEVVQQRF---ETLEPEMNTLAAQITAVND 913
Query: 1561 LGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFE 1620
+ L++ + G + + Q EQL W + K L A Q ++ + +
Sbjct: 914 IAEQLLKANP-PGKDRIVNTQ-EQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQ 971
Query: 1621 FWLSEAETLL-AMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTF 1679
W+ E ++ + + DLA L +K ER++ A + +L A L +
Sbjct: 972 AWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPA 1031
Query: 1680 NVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQ 1739
I + V + +++ E L EA L F + LDD ++W+ V+S+
Sbjct: 1032 QAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASE 1091
Query: 1740 DYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL-KDKAAVGQEEIQLRLAQFV 1798
+ L + LL +H L GE+ + + + E++ +D+A ++ RL
Sbjct: 1092 EGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALG 1151
Query: 1799 EHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLL 1858
WE+L + ++R +L ++ + F+++A + E ++ + + + TL A + +
Sbjct: 1152 TGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAI 1211
Query: 1859 MKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIA 1918
K E + + R+ + G ++++ + +E + IE ++K A+
Sbjct: 1212 KKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFL 1271
Query: 1919 AWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQ 1978
+L D+ Q F ++ WI +K + + + + + + T K A L
Sbjct: 1272 G---RLRDNREQQHFLQDCHELKLWIDEKMLTAQ-DVSYDEARNLHTKWQKHQAFMAELA 1327
Query: 1979 SFQQERLPEITDLKDKLISAQHNQSKA-IEERYAALLKRWEQLLEASAVHRQKLLEKQLP 2037
+ ++ L ++ D + + ++ + + KA + E+ L +RW++L + + L +
Sbjct: 1328 A-NKDWLDKV-DKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDAN-- 1383
Query: 2038 LQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQA 2097
+AE FA AL +W E ++ L + L + L K + +A +
Sbjct: 1384 --RAE----LFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREK 1437
Query: 2098 DFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQEL---QKEEARQVK 2154
+ + + Q KAL +ERT S +EE+ + L +E R+++
Sbjct: 1438 EVEAI---QAQAKALAQEDQG-----AGEVERT----SRAVEEKFRALCQPMRERCRRLQ 1485
Query: 2155 NFEMCQEFEQNASTFLQWILET--RAYFLDGS--------LLKETGTLESQLEAN----- 2199
+F ++ + W+ E A ++ L+K+ TL+ +++ +
Sbjct: 1486 ASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIA 1545
Query: 2200 --KRKQK------------EIQAMKRQLTKIVDL-GDNLEDALILDIKYSTIGLAQQWDQ 2244
+ +Q+ E+Q M ++L ++L G LEDAL Y A+ W
Sbjct: 1546 DLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMG 1605
Query: 2245 LYQLGLRMQHNLEQQIQAK-DIK--GVSEETLKEFS 2277
+L + Q + ++ A+ ++K V E+ L +++
Sbjct: 1606 EQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYA 1641
Score = 184 bits (467), Expect = 9e-46
Identities = 164/770 (21%), Positives = 343/770 (44%), Gaps = 26/770 (3%)
Query: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIME-KVNILTDKSYE 82
+ E+ +++ R+ + + + L D+ ++F + L W+ + + +D +
Sbjct: 1354 VSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGK 1413
Query: 83 DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREE--RFTMGHSAHEETKAHIEELRHLW 140
D T++ +K Q LE E+ + + + ++ + + G E T +EE +
Sbjct: 1414 DLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEK---F 1470
Query: 141 DLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKF 200
L + E+ +L + + Q+ ++ D + W+ ++ +A+S+E G+D ++L KK
Sbjct: 1471 RALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKN 1530
Query: 201 EDFQVELVAKEGRVVEVNQYANEC-AEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKA 259
+ Q E+ E R+ ++ + A P+L E+ W+RL R K
Sbjct: 1531 QTLQKEIQGHEPRIADLRERQRALGAAAAGPELA-------ELQEMWKRLGHELELRGKR 1583
Query: 260 LSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDK 319
L +A Q+F RD EA W+ E+E + ++ KD ++++ H+ LE+ LA +
Sbjct: 1584 LEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQT 1643
Query: 320 VKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDF 379
+ +L A ++ + ++ +I + + + ++ LA R E+LQ + +
Sbjct: 1644 IHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRREL 1703
Query: 380 DELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSY-DDRFQSADETGQDLVN 438
D+L W+ E+ + EL D +L D+ ++ + + +R SA+ L+
Sbjct: 1704 DDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIA 1763
Query: 439 ANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAF 498
H A V E + L+ W LLEL D R + + F + Q + + ++
Sbjct: 1764 GGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQ 1823
Query: 499 LENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRD 558
L + G L +AEAL ++H +E A ++ V +L Y + + I
Sbjct: 1824 LP-DGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRL--QKAYAGDKAEEIGR 1880
Query: 559 GLLARRDA---LREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDY-KDIQ 614
+ A +A L+ +A RR+LL ++ + ++ +L W+++ D ++ +D+
Sbjct: 1881 HMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVS 1940
Query: 615 NLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLE 674
+ ++ QQ + E+ + + G+E++ HYA++ ++ +LS++ + +E E
Sbjct: 1941 SADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAE 2000
Query: 675 ATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLES 734
++K L + L F +A + WL E V S + G + EV++ +++H +
Sbjct: 2001 KWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQK 2060
Query: 735 AVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLAT 784
+ A +++ L L A E + + R R+E + EP A+
Sbjct: 2061 SAVAWEERFCALEKLTALEER----EKERKRKREEEERRKQPPAPEPTAS 2106
Score = 92.8 bits (229), Expect = 4e-18
Identities = 110/528 (20%), Positives = 211/528 (39%), Gaps = 51/528 (9%)
Query: 1711 EAYALFQFFQDLDDEE-SWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAI 1769
EA L + ++ L E WIE+ ++ ++ + L GVQN L+ V P
Sbjct: 302 EAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYR--TVEKPPKF 359
Query: 1770 Q---NVLDMAEKLKDKAAVGQEEIQLR-----LAQFVEHWEKLKELAKARGLKL------ 1815
N+ + ++ K +++ ++ + WE+L++ R L L
Sbjct: 360 TEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIR 419
Query: 1816 EESLEYL--QFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHET 1873
+E LE L +F + A E W++E L + + G LAA ++ + KHEA+E D +
Sbjct: 420 QEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSG 479
Query: 1874 RVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWK----LQLEDDYA 1929
RVQ V A ++ + K I+++ + L + +AA + L LE
Sbjct: 480 RVQAVDAVAAEL---AAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKV 536
Query: 1930 FQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEIT 1989
FQ+ + D W+ + + L++ G L LL + ++A + + Q ER+ ++
Sbjct: 537 FQDLLYLMD----WMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADI-AVQAERVRAVS 591
Query: 1990 DLKDKLISAQHN----QSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLF 2045
+ + + + ER A L + +E L E +A R +L E +
Sbjct: 592 ASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRR--------L 643
Query: 2046 VEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLEL 2105
F + W + + L+ L +L H ++ K LE
Sbjct: 644 WRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQ 703
Query: 2106 DQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQN 2165
QQ+ A G P + L+ W+ L + EER Q L + + +F+ +
Sbjct: 704 GQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAAS--------LYQFQAD 755
Query: 2166 ASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQL 2213
A+ W+++ L + + ++ ++ ++EI++ + L
Sbjct: 756 ANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTL 803
Score = 40.4 bits (93), Expect = 0.021
Identities = 62/315 (19%), Positives = 124/315 (39%), Gaps = 25/315 (7%)
Query: 2010 YAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEP 2069
Y A + ++A AV +++ + +AE L ++ AS L W E+ L++
Sbjct: 272 YVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDR 331
Query: 2070 VHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLE-----LDQQIKALGVPS-SPYTWLT 2123
SL+ ++ + + + K LE + +++A +P
Sbjct: 332 QLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRL 391
Query: 2124 VEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDG 2183
+ + + W+ L ERE L+ E RQ K ++ F++ A+ W+ E +
Sbjct: 392 ISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQD 451
Query: 2184 SLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTI---GLAQ 2240
+ E +E+ + ++ + +I A ++ + + L DIK +A+
Sbjct: 452 NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVAR 511
Query: 2241 QWDQLYQLGL----RMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEF 2296
WD L Q+ R+ NLE Q +D+ + + + E + GRL ++
Sbjct: 512 LWDFLRQMVAARRERLLLNLELQKVFQDLLYLMD------------WMEEMKGRLQSQDL 559
Query: 2297 RSCLRGLNYYLPMVE 2311
L G+ L + E
Sbjct: 560 GRHLAGVEDLLQLHE 574
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 471 bits (1211), Expect = e-132
Identities = 357/1423 (25%), Positives = 669/1423 (47%), Gaps = 71/1423 (4%)
Query: 662 LSEVASLWEELLEATKQKGTQLH------EANQQL--QFENNAEDLQRWLEDVEWQVTSE 713
+S++ WE L EA ++ L E +QL +F+ A + WL + + V +
Sbjct: 389 VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448
Query: 714 DYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVC 773
++G LA V+ +KH +E+ AA +++V L DLA E+ + D K I AR+++++
Sbjct: 449 NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
Query: 774 RFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLN 833
+ L+E L +R+++L L LQ + +D W+ E + S GK L+ + LL
Sbjct: 509 LWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
Query: 834 RHRVILENIASHEPRIQEITERGNKMVEEGHFAAED---VASRVKSLNQNMESLRARAAR 890
+H+++ +IA +++ IT K E + D + R+ L Q E L AA
Sbjct: 569 KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
Query: 891 RQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNS 950
R+ LE + + ++ ++ EAE+WI+EKE I + +YG D + L +KH+AF +L
Sbjct: 629 RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
Query: 951 FGDSMKALRNQANAC-------QQQQAAPVEGVAGE---------------QRVMALYDF 988
++ + +A+ Q A ++ V+ + Q + F
Sbjct: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
Query: 989 QARSPREVTMKKGDVLTLLSS--INKDWWKVEAAD--HQGIVPAVYVRRLAHDEFPM--- 1041
Q + ++ D LLS + +D A H+ + + R +
Sbjct: 749 QGDAD-DLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQ 807
Query: 1042 -LPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQE 1100
P+ R+ P ++T R + + Y+ ++ +A+ R++RL + + + + E W+ E
Sbjct: 808 GFPEEFRDSP-DVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
Query: 1101 KKAENTGVELDDVWE----LQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQ 1156
K+ +E+ D E +Q +FD +++ T ++ +N A+ L+ G P +
Sbjct: 867 KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESG--HPRSRE 924
Query: 1157 IRQ---ELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQAL-SAADPG 1212
++Q LN+RW + Q L E+R+ + SA V + + ++T + I K + + S D G
Sbjct: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
Query: 1213 SDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWE 1272
DL + A+QR+ G ERD+ + +V L +++L +SHP+ ED+ +++ L E W+
Sbjct: 985 RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ 1044
Query: 1273 DLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQ 1332
LQ + +++ L E + FL D Q W+S V+S+++ E L E LL++H
Sbjct: 1045 GLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHA 1104
Query: 1333 EHRADMEAEAPTFQALEDFSAELIDSGHHASPE---IEKKLQAVKLERDDLEKAWEKRKK 1389
+ +++ ++Q +++ ++I PE + ++L+ + + L + WE R
Sbjct: 1105 GIKDEIDGHQDSYQRVKESGEKVIQG--QTDPEYLLLGQRLEGLDTGWNALGRMWESRSH 1162
Query: 1390 ILDQCLELQMFQGNCDQVESWMVARENSLRS-DDKSSLDSLEALMKKRDDLDKAITAQEG 1448
L QCL Q FQ + Q E+ + +E +L + SL++ EA ++K +D ++
Sbjct: 1163 TLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRD 1222
Query: 1449 KITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRD 1508
K+ L+A+ + ++I ++Q + DR + + + L D L+ F ++
Sbjct: 1223 KVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQN 1282
Query: 1509 LEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIEC 1568
+EL WI++ L T+ D SY +A N+ K+LKHQ F E+ + + G L++
Sbjct: 1283 CQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE 1342
Query: 1569 SACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAET 1628
+ ++LE L WD L T +K + L+ A + D W+S E
Sbjct: 1343 KP--QFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMED 1400
Query: 1629 LLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688
L D +DL S +L K + +E ++ R++ +L L + S G D +
Sbjct: 1401 QLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKE---ELGELFAQVPSMGEEGGDADL--- 1454
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748
++ KRFL++ E ++L+ + A Q +DL+DE W+EE+L S DYG +LQ V
Sbjct: 1455 -SIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTV 1513
Query: 1749 QNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELA 1808
Q +KK++ L+ E++ H P +++VL ++L + A + ++++ RL W++L+E A
Sbjct: 1514 QLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAA 1573
Query: 1809 KARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDF 1868
R +L ++ E Q+ +A+E EAWI E+ + + +L +H +
Sbjct: 1574 AGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAV 1633
Query: 1869 AVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDY 1928
+ ++ + ++ + +L+ E Q + +++ + L K +LE+ Y
Sbjct: 1634 EDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVD---KHYAGLKDVAEERKRKLENMY 1690
Query: 1929 AFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEI 1988
+ + D +E WI++KE + G D L K + QER+ +
Sbjct: 1691 HLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNV 1750
Query: 1989 TDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKL 2031
++LI A H+++ I E L + W LLE Q L
Sbjct: 1751 NAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLL 1793
Score = 428 bits (1101), Expect = e-119
Identities = 341/1378 (24%), Positives = 622/1378 (45%), Gaps = 72/1378 (5%)
Query: 23 EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY- 81
+I+ R +EV ++ K+ A + L+D+ + F+ DADDL W+ + +L+ +
Sbjct: 713 QIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVG 772
Query: 82 --EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHL 139
E T GK KH+ E++ +M LE+ + + F + ++ LR L
Sbjct: 773 QDEGATRALGK--KHKDFLEELEESRGVMEHLEQ-QAQGFPEEFRDSPDVTHRLQALREL 829
Query: 140 WDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKK 199
+ ++ + +L AL E W+G+KE +E+ + E EV+ +
Sbjct: 830 YQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHR 889
Query: 200 FEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKA 259
F+ E+ ++ VN AN E HP ++ Q+ +N W+ + L +R++A
Sbjct: 890 FDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREA 949
Query: 260 LSNAANLQRFKRDVTEAIQWIKEKEPVLTS-EDYGKDLVASEGLFHSHKGLERNLAVMSD 318
+ +A + + D E +WI +K V+ S +D G+DL + GLER++A +
Sbjct: 950 VDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
Query: 319 KVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSD 378
+V L ++++L SHP I + ++ L W+ ++ + + L F D
Sbjct: 1010 RVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQD 1069
Query: 379 FDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN 438
D+ W++ A+ ++++P + E LL +H K EID + D +Q E+G+ ++
Sbjct: 1070 LDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ 1129
Query: 439 ANHEASDEVR-EKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEA 497
+ + +++E LD W AL +W+ R QCL F F +D++Q ++ +S QE
Sbjct: 1130 GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEY 1189
Query: 498 FLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIR 557
L + + +SL +AEA ++K EDF + +K+++ + KL+ + + S+ IK
Sbjct: 1190 TLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKV 1249
Query: 558 DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLK 617
+ R EKA LL+++L LQ ++ +L WIN K + D Y + +NL
Sbjct: 1250 QLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLH 1309
Query: 618 SRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATK 677
++ K Q F ELA ++ LENI G+++++ + V+ +L + LW+EL TK
Sbjct: 1310 NKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTK 1369
Query: 678 QKGTQLHEA-NQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAV 736
+K L A + L+ + +A DL +W+ +E Q+ S+D GK L V L K +E V
Sbjct: 1370 EKTQHLSAARSSDLRLQTHA-DLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQV 1428
Query: 737 AARQDQV-DILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHL 795
R++++ ++ + + EE G D S+ RF L EPL RKK+L
Sbjct: 1429 NVRKEELGELFAQVPSMGEEGGDADL--------SIEKRFLDLLEPLGRRKKQLESSRAK 1480
Query: 796 QLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITER 855
I RD EDE W++E P A S G +L + + +++ + I H PR++++ +R
Sbjct: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
Query: 856 GNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWI 915
G ++VE +D+ R+ L + + LR AA R L + QQY D EAE WI
Sbjct: 1541 GQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600
Query: 916 REKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANAC------QQQQ 969
E+E V + DEE A +LK+H + +G ++K L ++A + +Q
Sbjct: 1601 GEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQ 1660
Query: 970 AAPVEGV----------AGEQRVMALYD----FQAR----------SPREVTMKKG---- 1001
++G E+R L + FQ + S +E+
Sbjct: 1661 IIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQ 1720
Query: 1002 --DVLTLLSSINKDWWKVEAADHQGIVPAV--YVRRLAHDEFPMLPQRRREEPGNITQRQ 1057
D +TLL +D+ + A Q V V ++ RL E I + +
Sbjct: 1721 DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLI--------DAGHSEAATIAEWK 1772
Query: 1058 EQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK---AENTGVELDDVW 1114
+ + + LL+ + R + L Y+ Y ++L I EK E+ G++
Sbjct: 1773 DGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAE 1832
Query: 1115 ELQKKFDEFQKDLNTNEPRLRDINKVADDL--LFEGLLTPEGAQIRQELNSRWGS-LQRL 1171
+ F+++L+ +++ VA L + G QE+++ W + L
Sbjct: 1833 SFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDAC 1892
Query: 1172 ADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERD 1231
A + QL+ +A F A D +E + + + D+ SV+ L + H+G +
Sbjct: 1893 AGRRTQLVDTADKFRFFSM-ARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAE 1951
Query: 1232 LVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKF 1291
+ + E E L + A+E+++ + ++ +++ + + R E L +
Sbjct: 1952 IETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEV 2011
Query: 1292 YLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALE 1349
F A + W+ + ++S + + +E L++RH+ + A F ALE
Sbjct: 2012 CQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALE 2069
Score = 373 bits (958), Expect = e-102
Identities = 331/1490 (22%), Positives = 641/1490 (43%), Gaps = 87/1490 (5%)
Query: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY-E 82
IQ+R + ++ A R +LE S L F + D+ WI EK I + Y +
Sbjct: 608 IQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGK 667
Query: 83 DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDL 142
D T++ +KH++ E E++ + ++ + H + +A I+E+ WD
Sbjct: 668 DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQ 727
Query: 143 LLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFED 202
L +L L A F Q+ + D+ W+ D + + ++G+D T L KK +D
Sbjct: 728 LKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKD 787
Query: 203 FQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSN 262
F EL G + + Q A EE D P + + + ++++ A RQ+ L
Sbjct: 788 FLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVVAQADLRQQRLQE 846
Query: 263 AANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKE 322
A +L + W+ EKE L + L E + H L++ + + ++
Sbjct: 847 ALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDG 906
Query: 323 LCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDEL 382
+ A L S + ++++ ++ L + W+ + L + R E + + H + D +E
Sbjct: 907 VNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEET 966
Query: 383 SGWMNEKTAAINAD-ELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANH 441
S W+ +KT + + +L D+AG + + + ++ + R + + Q L++++
Sbjct: 967 SKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
Query: 442 EASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLEN 501
E +++ ++ + L+ W L + + + F +D + +W+S + + +
Sbjct: 1027 EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS 1086
Query: 502 EDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLI-GDDHYDSENIKAIRDGL 560
ED+ SL AE LLQ+H ++ ++ V ++ K+I G + + +GL
Sbjct: 1087 EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGL 1146
Query: 561 LARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWI-NKKKKLADDEDYKDIQNLKSR 619
+AL +R L + L Q+ +D+ + + N++ LA E ++ ++
Sbjct: 1147 DTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAG 1206
Query: 620 VQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQK 679
++K + F + N+ ++ + +G +++ G+ SD + ++ + + E ++
Sbjct: 1207 IRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEA 1266
Query: 680 GTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAE-VQNRLRKHGLLESAVAA 738
L + + F N ++L W+ D +TS+D A + N+ KH + +A+
Sbjct: 1267 SVLLRDNLELQNFLQNCQELTLWINDK--LLTSQDVSYDEARNLHNKWLKHQAFVAELAS 1324
Query: 739 RQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLI 798
+ ++ + + + + + E+L ++ L+ + + L L
Sbjct: 1325 HEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR 1384
Query: 799 CRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNK 858
+ D WI E S GKDL + ++L + + + + + + + E+ +
Sbjct: 1385 LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPS 1444
Query: 859 MVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREK 918
M EEG A + R L + + RR+ LE++ Q DL + W+ E+
Sbjct: 1445 MGEEGGDADLSIEKRFLDLLEPL-------GRRKKQLESSRAKLQISRDLEDETLWVEER 1497
Query: 919 EPIVDNTNYGADEEAAGALLKKH-------------------------EAFLLDLNSFGD 953
P+ + +YG + + +KK+ EA +D +
Sbjct: 1498 LPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEE 1557
Query: 954 SMKALRNQ-----------------ANACQQQ--QAAPVEGVAGEQRVMALYDFQARSPR 994
+ L++ AN QQ A E GEQ + + D
Sbjct: 1558 RLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISD------- 1610
Query: 995 EVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNIT 1054
E+ + + +L + VE +++LA +L E I
Sbjct: 1611 EIPKDEEGAIVMLKRHLRQQRAVEDYGRN-------IKQLASRAQGLL-SAGHPEGEQII 1662
Query: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----AENTGVEL 1110
+ Q Q++ Y L D AEER+R+L Y+ F L E D+ +WI EK+ + G +
Sbjct: 1663 RLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDF 1722
Query: 1111 DDVWELQKKFDEFQKDLNT-NEPRLRDINKVADDLLFEGLLTPEGAQI---RQELNSRWG 1166
D V L+ KF +F ++ + R+ ++N + L+ G E A I + LN W
Sbjct: 1723 DHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAG--HSEAATIAEWKDGLNEMWA 1780
Query: 1167 SLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHE 1226
L L D + QLL +++ + + + I++K + L D G D + ++ R H
Sbjct: 1781 DLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPE-DVGLDASTAESFHRVHT 1839
Query: 1227 GFERDLVPLGDKVTILGETAERLSESHP-DATEDLQRQKMELNEAWEDLQGRTKDRKESL 1285
FER+L LG +V + A RL ++ + E +Q ++ E++ AW+ L R+ L
Sbjct: 1840 AFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQL 1899
Query: 1286 NEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTF 1345
+ + F S ARDL +W+ SI + +QE D++ +E+L++ HQ A++E + F
Sbjct: 1900 VDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
Query: 1346 QALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCD 1405
A + L+ H AS EI +KLQ V R ++ + WE R + L LE+ F +
Sbjct: 1960 SACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDAS 2019
Query: 1406 QVESWMVARENSLRSDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDLE 1454
E+W++A+E L S D ++DS+E L+K+ + +K+ + + LE
Sbjct: 2020 VAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALE 2069
Score = 367 bits (942), Expect = e-101
Identities = 373/1695 (22%), Positives = 735/1695 (43%), Gaps = 90/1695 (5%)
Query: 240 NEVNAAWERLRGLALQRQKALSNAANLQ--------RFKRDVTEAIQWIKEKEPVLTSED 291
+++N AWE L +R+ AL N Q RF R W+ E + ++ ++
Sbjct: 390 SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDN 449
Query: 292 YGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSS 351
+G DL A E H+ +E + A ++V+ L A++L + D +I K++++
Sbjct: 450 FGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRL 509
Query: 352 WEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411
W +++ L SR ++L+ T + D WM+E A + + E + E LL +
Sbjct: 510 WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQK 569
Query: 412 HQQHKHEIDSYDDRFQSADETGQDLVNAN-HEASDE--VREKMEILDNNWTALLELWDER 468
H+ + +I D+ ++ ++ D +++++ L+ + L + R
Sbjct: 570 HKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGR 629
Query: 469 HRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQ 528
Q EQ F+ + ++ +SW+ +E + D G L S L +KH+ FE+
Sbjct: 630 KAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGL 689
Query: 529 EEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLY 588
+ + + + A ++ + I+A + A+ D L++ AA ++ L+++ +
Sbjct: 690 DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQ 749
Query: 589 EDSDDLKNWINKKKKLADDEDY-KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEM 647
D+DDLK W+ +L ED +D ++ +K + F +EL ++ +E++++ Q
Sbjct: 750 GDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF 809
Query: 648 IEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQF--ENNAEDL-----Q 700
E + D VT RL + L+++++ + +L EA E +A +L +
Sbjct: 810 PEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKE 868
Query: 701 RWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPD 760
+WL ++E T ED L VQ+R +L+ + Q+D + A E GHP
Sbjct: 869 KWLAEMEMPDTLED----LEVVQHRF---DILDQEMKTLMTQIDGVNLAANSLVESGHPR 921
Query: 761 SKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY 820
S++++ Q+ L R++A + ++ R++ + L + C D E+ WI + ST
Sbjct: 922 SREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK 981
Query: 821 -LGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQ 879
LG+DL + + + ++A+ + R+ + ++++ ED+ R K L +
Sbjct: 982 DLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEE 1041
Query: 880 NMESLRARAARRQNDLEANV-QFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALL 938
+ L+ ++ + Q DL V Q Q +L DL + + W+ + V + + A LL
Sbjct: 1042 LWQGLQ-QSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLL 1100
Query: 939 KKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQ------------------ 980
++H +++ DS + ++ Q Q P + G++
Sbjct: 1101 QQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESR 1160
Query: 981 -----RVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLA 1035
+ + +FQ + + + TL D + A + +
Sbjct: 1161 SHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENN 1220
Query: 1036 HDEF--PMLPQRRREEPGN-----ITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLA 1088
D+ P+ + GN I ++ + IE+++R ++A+E L
Sbjct: 1221 RDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFL 1280
Query: 1089 YEAGDMLEWIQEKKAENTGVELDDVWELQKKF---DEFQKDLNTNEPRLRDINKVADDLL 1145
++ WI +K + V D+ L K+ F +L ++E L +I+ L+
Sbjct: 1281 QNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLM 1340
Query: 1146 FEG-LLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQ 1204
E T +Q + L+ W LQ E+ Q L +A + ++ + D + I
Sbjct: 1341 DEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMED 1400
Query: 1205 ALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQK 1264
L + DPG DL SV + + + E + +++ L + E DA ++++
Sbjct: 1401 QLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRF 1460
Query: 1265 MELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQN---WISSIGGMVSSQELAEDL 1321
++L E GR K + ES L +RDL++ W+ + S + +L
Sbjct: 1461 LDLLEPL----GRRKKQLESSRAK------LQISRDLEDETLWVEERLPLAQSADYGTNL 1510
Query: 1322 TGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLE 1381
+++ ++++Q + ++ P + + +L+++ ++E++L ++ D L
Sbjct: 1511 QTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLR 1570
Query: 1382 KAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDK 1441
+A R + L E Q + + D+ E+W+ +E + SD+ + +M KR +
Sbjct: 1571 EAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQ 1630
Query: 1442 AITAQEGK-ITDLEHFAESLIADEHYAKEEIATRLQRVLDR-WKALKAQLIDERTKLGDY 1499
G+ I L A+ L++ H E+I RLQ +D+ + LK + + KL +
Sbjct: 1631 RAVEDYGRNIKQLASRAQGLLSAGHPEGEQII-RLQGQVDKHYAGLKDVAEERKRKLENM 1689
Query: 1500 ANLKQFYRDLEELEEWISEM-LPTACDESYKDATNIQRKYLKHQTFAHEVDG-RSEQVHG 1557
+L Q R+ ++LE+WISE L + E +D ++ K + FA E E+V
Sbjct: 1690 YHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDN 1749
Query: 1558 VINLGNSLIECSACDGNEEA--MKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTS 1615
V N+ IE G+ EA + E + L E W LLE + + + L + R+ +
Sbjct: 1750 V----NAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYT 1805
Query: 1616 IRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLS 1675
+ + E L +D D ++A + + H ERE+ ++ +A L +
Sbjct: 1806 GAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQT 1864
Query: 1676 S-GTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLI 1734
+ + I K+ V+ + + + A +L + F+FF D SW+E +
Sbjct: 1865 AYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIR 1924
Query: 1735 RVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRL 1794
++ +Q+ RD+ V+ L+K H+ + E+ L++ E L + EEI+ +L
Sbjct: 1925 QIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKL 1984
Query: 1795 AQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAAT 1854
Q + +++ E +AR +L LE QF ++A EAW+ + GD G T+ +
Sbjct: 1985 QQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSV 2044
Query: 1855 QSLLMKHEALENDFA 1869
+ L+ +HEA E A
Sbjct: 2045 EKLIKRHEAFEKSTA 2059
Score = 362 bits (929), Expect = 2e-99
Identities = 341/1698 (20%), Positives = 712/1698 (41%), Gaps = 72/1698 (4%)
Query: 5 PKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64
P + + S + E+ EE + RR+ L +E++ + ++ F R A
Sbjct: 383 PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---------FDRKAAM 433
Query: 65 LGKWIMEKVNILTDKSYE-DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGH 123
W+ E ++ ++ D ++ +KH+++E + + LE +E +
Sbjct: 434 RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493
Query: 124 SAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATS 183
+ A + + LW L EL + +L L Q+ Q+ ++W+ + +A S
Sbjct: 494 HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLS 553
Query: 184 VELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEEN--HP-DLPLIQSKQN 240
E G+ E L +K + + ++ + +V + + E P D +IQ + +
Sbjct: 554 AEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRIS 613
Query: 241 EVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASE 300
+ +E L +A R+ L + L +F ++ EA WIKEKE + +S DYGKDL +
Sbjct: 614 HLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVL 673
Query: 301 GLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALAT 360
L HK E L + ++++ +A + PQI+ +++ + W+ ++ LA
Sbjct: 674 ILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAA 733
Query: 361 SRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEID 420
+ LQ + +F D D+L W+ + ++ +++ D L +H+ E++
Sbjct: 734 FCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793
Query: 421 SYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHL 480
+ ++ Q ++ D V +++ L + ++ D R ++ ++ LD +
Sbjct: 794 ESRGVMEHLEQQAQGFPEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEALDLYT 852
Query: 481 FYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTAT 540
+ +++ + WM +E +L ++ ++L E + + + ++ +I V+ A
Sbjct: 853 VFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAAN 912
Query: 541 KLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINK 600
L+ H S +K +D L R A + + RR + +L + D ++ WI
Sbjct: 913 SLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITD 972
Query: 601 KKKLADD--EDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNV 658
K K+ + + +D+ + + +K E+++A + +++ +++ Q++++ +++
Sbjct: 973 KTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
Query: 659 TTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKG 718
R + LW+ L ++ + + L E +Q F + +D Q WL + V SED +
Sbjct: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPES 1092
Query: 719 LAEVQNRLRKHGLLESAVAARQDQVDILTDLA-AYFEEIGHPDSKDIRARQESLVCRFEA 777
L E + L++H ++ + QD + + + P+ + R E L + A
Sbjct: 1093 LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNA 1152
Query: 778 LKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRV 837
L +R L L Q +D + EA + E + L A++ + +
Sbjct: 1153 LGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFED 1212
Query: 838 ILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEA 897
L ++ ++ ++ + GNK+V EG+ ++ + +V+ + +A L
Sbjct: 1213 FLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRD 1272
Query: 898 NVQFQQYLADLHEAETWIREKEPIVDNTNYG---------ADEEAAGALLKKHEAFLLDL 948
N++ Q +L + E WI +K + +Y +A A L HE +L ++
Sbjct: 1273 NLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENI 1332
Query: 949 NSFGDSMKALRNQANACQQQQAAPVEGVAGE---------QRVMALYDFQAR-------- 991
++ G + + Q A Q+ + + E Q + A R
Sbjct: 1333 DAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLN 1392
Query: 992 ---SPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRRE 1048
S E ++ D L+S+N+ K++ + Q V VR+ E E
Sbjct: 1393 KWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQ-----VNVRKEELGELFAQVPSMGE 1447
Query: 1049 EPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEK----KAE 1104
E G+ IE ++ LL+ R+++L + ++ + D W++E+ ++
Sbjct: 1448 EGGD---ADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSA 1504
Query: 1105 NTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR-QELNS 1163
+ G L V KK Q ++ + PR+ D+ + L+ + + + R L S
Sbjct: 1505 DYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQS 1564
Query: 1164 RWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQI-EKKCQALSAADPGSDLFSVQALQ 1222
W L+ A + Q L A+ + ++ +AD+ + I E++ +S P + ++ L
Sbjct: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVML- 1623
Query: 1223 RRHEGFERDLVPLGDKVTILGETAE-RLSESHPDATEDLQRQKMELNEAWEDLQGRTKDR 1281
+RH +R + G + L A+ LS HP+ E + R + ++++ + L+ ++R
Sbjct: 1624 KRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEG-EQIIRLQGQVDKHYAGLKDVAEER 1682
Query: 1282 KESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEA- 1340
K L + + DL+ WIS + SS E+ +D + +L ++ ++ + A
Sbjct: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAI 1742
Query: 1341 EAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMF 1400
+ F LID+GH + I + + DL + + R ++L +L +
Sbjct: 1743 GQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRY 1802
Query: 1401 QGNCDQVESWMVARENSLRSD---DKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFA 1457
++ + + L D D S+ +S + + + Q + D+
Sbjct: 1803 FYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRL 1862
Query: 1458 ESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWIS 1517
++ A E E I + Q V W+AL RT+L D A+ +F+ +L W+
Sbjct: 1863 QTAYAGE--KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME 1920
Query: 1518 EML-PTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE 1576
++ E +D ++++ HQ E++ RS+ + LG SL++ E
Sbjct: 1921 SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ--HQASE 1978
Query: 1577 AMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQA 1636
++E+L+Q+ + E+ + ++L +F+ E WL E LA D
Sbjct: 1979 EIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFG 2038
Query: 1637 RDLASAGNLLKKHQLLER 1654
+ S L+K+H+ E+
Sbjct: 2039 HTVDSVEKLIKRHEAFEK 2056
Score = 328 bits (842), Expect = 3e-89
Identities = 373/1839 (20%), Positives = 739/1839 (40%), Gaps = 131/1839 (7%)
Query: 259 ALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEG---LFHSHKGLER---- 311
A+ ++++ ++ + WI++ VL S + L + F +++ +E+
Sbjct: 297 AIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKF 356
Query: 312 ----NLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKE--DLVSSWEHIRALATS---- 361
NL V+ ++ +A + P D + ++ + + E+ R LA
Sbjct: 357 QEKGNLEVLLFTIQSRM-RANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI 415
Query: 362 RYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDS 421
R EKL+ RF W++E + D D+A E +H+ + + +
Sbjct: 416 RQEKLEQLA--RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAA 473
Query: 422 YDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLF 481
Y++R ++ ++ Q+L N+ + + + + W+ L EL R ++ E L
Sbjct: 474 YEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKL 533
Query: 482 YRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATK 541
++D WM +A L + + G L E LLQKH+ E Q +K+ + K
Sbjct: 534 FQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLK 593
Query: 542 LIGDDHYDSENIKAIRDGLLARRDALRE---KAATRRRLLKESLLLQKLYEDSDDLKNWI 598
Y + + I+D + E AA R+ L++S L K + + D+ ++WI
Sbjct: 594 FTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWI 653
Query: 599 NKKKKLADDEDY-KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDN 657
+K+++ DY KD+ ++ +K + FE EL LE I + M+ +
Sbjct: 654 KEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQ 713
Query: 658 VTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGK 717
+ R+ EV++ W++L + L +A QF+ +A+DL+ WL+D ++ ED G+
Sbjct: 714 IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773
Query: 718 GLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEA 777
+ +KH + + ++ L A F E DS D+ R ++L ++
Sbjct: 774 DEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPE-EFRDSPDVTHRLQALRELYQQ 832
Query: 778 LKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRV 837
+ R+++L + L L + +T+ E W+ E E + L + + +R +
Sbjct: 833 VVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDI 892
Query: 838 ILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEA 897
+ + + + +I + N +VE GH + +V LN ++ + + R+ +++
Sbjct: 893 LDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDS 952
Query: 898 NVQFQQYLADLHEAETWIREKEPIVDNT-NYGADEEAAGALLKKHEAFLLDLNSFGDSMK 956
++ Y D E WI +K +V++T + G D A+ +K D+ + +
Sbjct: 953 ALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVD 1012
Query: 957 ALRNQANACQQQQAAPVEGVAGEQRVMA-LYDFQARSPREVTMKKGDVLTLLSSINKDWW 1015
AL ++ E + Q+ + L+ +S + G+V L + +
Sbjct: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQ---- 1068
Query: 1016 KVEAADHQGIVPAVYVRRLAHDEFP-MLPQ----------------------RRREEPGN 1052
+ D Q + ++ + +A ++ P LP+ +R +E G
Sbjct: 1069 --DLDDFQAWL-SITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGE 1125
Query: 1053 -------------ITQRQEQIENQYRSLLDRAEERRRRLLQ--RYNEFLLAYEAGDMLEW 1097
+ QR E ++ + +L E R L Q + EF + + +
Sbjct: 1126 KVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILS 1185
Query: 1098 IQEKKAENTGVELDDVWELQ----KKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPE 1153
QE + +E D E +KF++F + N ++ + L+ EG L +
Sbjct: 1186 NQEYTLAH--LEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSD 1243
Query: 1154 GAQIRQEL-NSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPG 1212
+ + +L R A E LL ++ F + + I K L++ D
Sbjct: 1244 KIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL--LTSQDVS 1301
Query: 1213 SD-LFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAW 1271
D ++ +H+ F +L + + ++L + P T + ++ L+ W
Sbjct: 1302 YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLW 1361
Query: 1272 EDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERH 1331
++LQ TK++ + L+ A+ L L DL WIS++ + S + +DLT + +L +
Sbjct: 1362 DELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
Query: 1332 QEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKIL 1391
+ + L + + G A IEK+ DL + +RKK L
Sbjct: 1422 KRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFL-------DLLEPLGRRKKQL 1474
Query: 1392 DQCLELQMFQGNCDQVESWMVARENSLRSDDK-SSLDSLEALMKKRDDLDKAITAQEGKI 1450
+ + + W+ R +S D ++L +++ MKK L I ++
Sbjct: 1475 ESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRV 1534
Query: 1451 TDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLE 1510
D+ + L+ +++ RL + W L+ +L D +Q+Y D +
Sbjct: 1535 EDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDAD 1594
Query: 1511 ELEEWISEM-LPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECS 1569
E E WI E L DE KD +H V+ + + + L+
Sbjct: 1595 EAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAG 1654
Query: 1570 ACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETL 1629
+G E+ ++ Q Q+ +H+ L + ++ +KL + D E W+SE E +
Sbjct: 1655 HPEG-EQIIRLQ-GQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELV 1712
Query: 1630 LAMKDQARDLASAGNLLKKHQLLEREMLA-REDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688
+ + +D L K + RE A ++ + ++N E L+ +G I + K
Sbjct: 1713 ASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWK 1772
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748
D +N+ + ++ EL + L +Y L ++F + I+EK R +D G D
Sbjct: 1773 DGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKH-RELPEDVGLDASTA 1831
Query: 1749 QNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDK-AAVGQEEIQLRLAQFVEHWEKLKEL 1807
++ + H E EL +Q D+A +L+ A E IQ + + W+ L +
Sbjct: 1832 ESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDA 1891
Query: 1808 AKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALEND 1867
R +L ++ + +F A + +W+ + +++ + L+ H+ + +
Sbjct: 1892 CAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAE 1951
Query: 1868 FAVHETRVQNVCA--------------QGEDILNKVLQEESQNKEISSKIEALNEKTPSL 1913
ETR +N A E+I K+ Q S+ KE++ K EA E+ L
Sbjct: 1952 I---ETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRML 2008
Query: 1914 AKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTL 1973
+ +F+ A V EAW+ +E L + G + L+ + +
Sbjct: 2009 LEVC--------------QFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAF 2054
Query: 1974 DASLQSFQQE----RLPEITDLKDKLISAQHNQSKAIEE 2008
+ S S+ + P +LK++ I+ + + +E
Sbjct: 2055 EKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQE 2093
Score = 270 bits (689), Expect = 2e-71
Identities = 197/857 (22%), Positives = 385/857 (44%), Gaps = 27/857 (3%)
Query: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKS 80
+++I+E+ Q + R++ E+ E L D+ LQ F ++ +L WI +K+ D S
Sbjct: 1242 SDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS 1301
Query: 81 YEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLW 140
Y++ N+ K+ KHQ+ AE+ + + ++ ++ +E L LW
Sbjct: 1302 YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLW 1361
Query: 141 DLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKF 200
D L T EK L A +Q AD+ +WI E S + G+D
Sbjct: 1362 DELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVN------ 1415
Query: 201 EDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWER-----LRGLALQ 255
++AK RV + E E +P + + + + + E+ L L +
Sbjct: 1416 -----RMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRR 1470
Query: 256 RQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAV 315
+++ S+ A LQ RD+ + W++E+ P+ S DYG +L + ++ L+ +
Sbjct: 1471 KKQLESSRAKLQ-ISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
Query: 316 MSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRF 375
+ +V+++ + ++L + D ++E L SSW+ +R A R ++L+ ++
Sbjct: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQY 1589
Query: 376 SSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQD 435
D DE W+ E+ + +DE+P D G V+L RH + + ++ Y + Q
Sbjct: 1590 YLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQG 1649
Query: 436 LVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFY--RDSEQVDSWMS 493
L++A H +++ +D ++ L ++ +ER R+ E +HLF R+++ ++ W+S
Sbjct: 1650 LLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENM--YHLFQLKRETDDLEQWIS 1707
Query: 494 RQEAFLENEDLGNSLGSAEALLQKHEDF-EEAFTAQEEKIITVDKTATKLIGDDHYDSEN 552
+E + ++G L K DF E +E++ V+ +LI H ++
Sbjct: 1708 EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAAT 1767
Query: 553 IKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD 612
I +DGL L E TR +LL S L + + ++ I++K + ++ D
Sbjct: 1768 IAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLD 1827
Query: 613 IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDN---VTTRLSEVASLW 669
+S + FE+EL + Q++ Q + YA + + + EV++ W
Sbjct: 1828 ASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTA--YAGEKAEAIQNKEQEVSAAW 1885
Query: 670 EELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729
+ LL+A + TQL + + +F + A DL W+E + Q+ +++ + ++ V+ ++ H
Sbjct: 1886 QALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYH 1945
Query: 730 GLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKL 789
+ + + R +L + H S++IR + + ++ R + + E R ++L
Sbjct: 1946 QGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERL 2005
Query: 790 LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849
LL + RD EAW+ EP S G + + +KL+ RH ++ AS R
Sbjct: 2006 RMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERF 2065
Query: 850 QEITERGNKMVEEGHFA 866
+ + ++E A
Sbjct: 2066 AALEKPTTLELKERQIA 2082
Score = 244 bits (623), Expect = 7e-64
Identities = 285/1461 (19%), Positives = 593/1461 (40%), Gaps = 94/1461 (6%)
Query: 691 QFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQ-------- 742
++ A DL W+E + S + L VQ +L+ + + Q
Sbjct: 306 KYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVL 365
Query: 743 -VDILTDLAAYFEEIGHP-DSK---DIRARQESL----VCRFEALKEPLATRKKKLLDLL 793
I + + A +++ P D K DI ESL R AL+ L R++KL L
Sbjct: 366 LFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI-RQEKLEQLA 424
Query: 794 HLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEIT 853
+ R E W+ E + G DL A + +H I + A++E R++ +
Sbjct: 425 --RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALE 482
Query: 854 ERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAET 913
+ ++ +E + + + +R ++ + L+ R+ LE + Q+ D+ +
Sbjct: 483 DLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSID 542
Query: 914 WIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQA-AP 972
W+ E + + + +G LL+KH+ D+ GD +KA+ + + P
Sbjct: 543 WMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQP 602
Query: 973 VEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAA------------ 1020
+ + R+ L +K L + K +W+++ A
Sbjct: 603 CDPQVIQDRISHLEQCFEELSNMAAGRKAQ-LEQSKRLWKFFWEMDEAESWIKEKEQIYS 661
Query: 1021 --DHQGIVPAVYVRRLAHDEFP--------MLPQRRREEPGNITQRQ----------EQI 1060
D+ + +V + + H F L Q +E G + ++Q +++
Sbjct: 662 SLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEV 721
Query: 1061 ENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEK----KAENTGVELDDVWEL 1116
Q+ L D A ++ L N F +A D+ W+Q+ E+ G + L
Sbjct: 722 SAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRAL 781
Query: 1117 QKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQR 1176
KK +F ++L + + + + A E +P+ Q L + + AD ++
Sbjct: 782 GKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQ 841
Query: 1177 QLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLG 1236
Q L A + E D + + +K + L+ + L ++ +Q R + ++++ L
Sbjct: 842 QRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLM 901
Query: 1237 DKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLS 1296
++ + A L ES + ++++ + LN W+ Q +R+E+++ A + + +
Sbjct: 902 TQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCV 961
Query: 1297 KARDLQNWISSIGGMV-SSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAEL 1355
+ WI+ +V S+++L DL GI + + D+ A ALE S +L
Sbjct: 962 DCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL 1021
Query: 1356 IDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARE 1415
+DS +I ++ + ++ L+++ + ++ +L + +LQ F + D ++W+ +
Sbjct: 1022 MDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ 1081
Query: 1416 NSLRSDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLI---ADEHYAKEEI 1471
++ S+D SL E L+++ + I + ++ E +I D Y +
Sbjct: 1082 KAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLL--L 1139
Query: 1472 ATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDA 1531
RL+ + W AL L ++F +D ++ E +S T D+
Sbjct: 1140 GQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS 1199
Query: 1532 TNIQRKYL-KHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGN--EEAMKEQLEQLKEH 1588
+ K + F ++ ++V ++ GN L+ +GN + +KE+++ +++
Sbjct: 1200 LEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLV----AEGNLYSDKIKEKVQLIEDR 1255
Query: 1589 WDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLA-SAGNLLK 1647
E+ + L + Q F + ++ W++ + LL +D + D A + N
Sbjct: 1256 HRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWIN--DKLLTSQDVSYDEARNLHNKWL 1313
Query: 1648 KHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHE 1707
KHQ E+ + E L++++ + L+ + +K + +++ + +Q +
Sbjct: 1314 KHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQ 1373
Query: 1708 KLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEP 1767
L A + Q D WI ++ S D G+DL V +L K KR+E ++ +
Sbjct: 1374 HLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKE 1433
Query: 1768 AIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQN 1827
+ + + ++ I+ R +E + K+ +LE S LQ ++
Sbjct: 1434 ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKK-------QLESSRAKLQISRD 1486
Query: 1828 AEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILN 1887
E+E W+ E+ LA D G L Q + K++ L+N+ H RV++V +G+ ++
Sbjct: 1487 LEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVE 1546
Query: 1888 KVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADK 1947
E +++ ++ L L +A A +L D Q++ AD EAWI ++
Sbjct: 1547 AA---EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQ 1603
Query: 1948 ETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIE 2007
E + ++ D + +L + +++ + + + ++ L+SA H + + I
Sbjct: 1604 ELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGR-NIKQLASRAQGLLSAGHPEGEQII 1662
Query: 2008 ERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLS 2067
+ K + L + + ++K L+ LF + + L W + E S
Sbjct: 1663 RLQGQVDKHYAGLKDVAEERKRK-------LENMYHLF-QLKRETDDLEQWISEKELVAS 1714
Query: 2068 EPVHCVSLNEIRQLQKDHEDF 2088
P + + L+ DF
Sbjct: 1715 SPEMGQDFDHVTLLRDKFRDF 1735
Score = 237 bits (604), Expect = 1e-61
Identities = 261/1328 (19%), Positives = 527/1328 (39%), Gaps = 89/1328 (6%)
Query: 15 PKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVN 74
P+ + ++ R Q + YQ + R Q+L+++ L + D W+ EK
Sbjct: 810 PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEK 869
Query: 75 ILTDKSYEDPT-NIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHI 133
L + D +++ + L+ E++T + + GH E K +
Sbjct: 870 WLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQ 929
Query: 134 EELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSV-ELGEDWER 192
+ L W L E+ + + AL+ Y +C + +WI DK + S +LG D
Sbjct: 930 DHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAG 989
Query: 193 TEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGL 252
+ +K + ++ A + RV + + + + + + I +Q + W+ L+
Sbjct: 990 IIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQS 1049
Query: 253 ALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERN 312
++ L + LQ F +D+ + W+ + + SED + L +E L H G++
Sbjct: 1050 LQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDE 1109
Query: 313 LAVMSDKVKELCAKAEKLTLSHPS-DAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYW 371
+ D + + EK+ + + + E L + W + + SR L
Sbjct: 1110 IDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLG 1169
Query: 372 YHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADE 431
+ F D + ++ + + E P + E + + + +++ D+ S +
Sbjct: 1170 FQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVD 1229
Query: 432 TGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSW 491
+G LV + SD+++EK++++++ E E L+ F ++ +++ W
Sbjct: 1230 SGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLW 1289
Query: 492 MSRQEAFLENEDLG-NSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDS 550
++ + L ++D+ + + KH+ F + E + +D +L+ + +
Sbjct: 1290 IN--DKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFT 1347
Query: 551 ENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKK-KLADDED 609
+ + L D L+ + + L + + DL WI+ + +L D+
Sbjct: 1348 ALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDP 1407
Query: 610 YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLW 669
KD+ ++ + K + E ++ V K +L + M E G A ++ R +
Sbjct: 1408 GKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLD----- 1462
Query: 670 EELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729
LLE ++ QL + +LQ + ED W+E+ S DYG L VQ ++K+
Sbjct: 1463 --LLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKN 1520
Query: 730 GLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKL 789
L++ + +V+ + E D +D+ R L ++ L+E A R ++L
Sbjct: 1521 QTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRL 1580
Query: 790 LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849
D Q D ++ EAWI E E S + KD + +L RH + + I
Sbjct: 1581 RDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNI 1640
Query: 850 QEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLH 909
+++ R ++ GH E + ++++ L+ A R+ LE Q +
Sbjct: 1641 KQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD 1700
Query: 910 EAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFG----DSMKALRNQANAC 965
+ E WI EKE + + G D + L K F + + G D++ A +
Sbjct: 1701 DLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDA 1760
Query: 966 QQQQAAPV----EGV------------AGEQRVMALYDFQA-------------RSPREV 996
+AA + +G+ Q + A YD RE+
Sbjct: 1761 GHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHREL 1820
Query: 997 TMKKGDVLTLLSSINKDWWKVEAADHQGI-VPAVYVRRLAHDEFPMLPQRRREEPGNITQ 1055
G L +S + + +V A + + + V V++ + E+ I
Sbjct: 1821 PEDVG----LDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQN 1876
Query: 1056 RQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWI---------QEKKAENT 1106
+++++ +++LLD RR +L+ ++F A D+L W+ QE+ + +
Sbjct: 1877 KEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVS 1936
Query: 1107 GVELDDVW------ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE 1160
VEL + E++ + F L E L+ ++ ++++ + + R+E
Sbjct: 1937 SVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREK---LQQVMSRRKE 1993
Query: 1161 LNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQA 1220
+N +W + + R LL V F R+A + + + L++ D G + SV+
Sbjct: 1994 MNEKW---EARWERLRMLL----EVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEK 2046
Query: 1221 LQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKD 1280
L +RHE FE+ AER + T +L+ +++ A E G ++
Sbjct: 2047 LIKRHEAFEKS----------TASWAERFAALEKPTTLELKERQIAERPAEE--TGPQEE 2094
Query: 1281 RKESLNEA 1288
E+ EA
Sbjct: 2095 EGETAGEA 2102
Score = 227 bits (578), Expect = 1e-58
Identities = 262/1268 (20%), Positives = 522/1268 (41%), Gaps = 83/1268 (6%)
Query: 994 REVTMKKGDVLTLLSSINKDWWKVEAAD--HQGIVP--AVYVRRLA--HDEFPMLPQRRR 1047
RE + + L + D VEAA H+ I A Y R+ D L +
Sbjct: 434 RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493
Query: 1048 EEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAE--- 1104
+ IT R++ I + L + + RR+RL L + ++W+ E KA
Sbjct: 494 HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLS 553
Query: 1105 -NTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE--- 1160
G L +V +L +K + D+ +++ I P Q+ Q+
Sbjct: 554 AEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRIS 613
Query: 1161 -LNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQ 1219
L + L +A ++ L + + F E D+ + I++K Q S+ D G DL SV
Sbjct: 614 HLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVL 673
Query: 1220 ALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTK 1279
LQR+H+ FE +L L + + + A + ++ + E++ W+ L+
Sbjct: 674 ILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAA 733
Query: 1280 DRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADME 1339
K++L +A+ F+ F A DL+ W+ ++S +++ +D L ++H++ ++E
Sbjct: 734 FCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793
Query: 1340 AEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQM 1399
+ LE A+ SP++ +LQA++ + + R++ L + L+L
Sbjct: 794 ESRGVMEHLEQ-QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYT 852
Query: 1400 FQGNCDQVESWMVARENSL-RSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAE 1458
G D E WM +E L + +L+ LE + + D LD+ + +I + A
Sbjct: 853 VFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAAN 912
Query: 1459 SLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISE 1518
SL+ H E+ + RW+A + + + R + + + D EE +WI++
Sbjct: 913 SLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITD 972
Query: 1519 MLPTACDESYKDATN-------IQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSAC 1571
T ES KD IQRK +V +V + L++ +
Sbjct: 973 --KTKVVESTKDLGRDLAGIIAIQRKL---SGLERDVAAIQARVDALERESQQLMD--SH 1025
Query: 1572 DGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLA 1631
+E + ++ + L+E W L + + L E S+ Q F + DF+ WLS + +A
Sbjct: 1026 PEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVA 1085
Query: 1632 MKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIV-KKKDN 1690
+D L A LL++H ++ E+ +D+ + + E ++ T ++ ++ +
Sbjct: 1086 SEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEG 1145
Query: 1691 VNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQN 1750
++ + + + + L + +F +D E+ + + ++ + L+ +
Sbjct: 1146 LDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEA 1205
Query: 1751 LLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKA 1810
++K + G + + + + +D KL + + ++I+ ++ + K E A+
Sbjct: 1206 GIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQE 1265
Query: 1811 RGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAV 1870
+ L ++LE F+QN +E WIN+K L + D + +KH+A + A
Sbjct: 1266 ASVLLRDNLELQNFLQNCQELTLWINDK-LLTSQDVSYDEARNLHNKWLKHQAFVAELAS 1324
Query: 1871 HETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALN-----------EKTPSLAKAIAA 1919
HE ++N+ A+G+ ++++ Q + +S K+EAL+ EKT L+ A ++
Sbjct: 1325 HEGWLENIDAEGKQLMDEKPQFTAL---VSQKLEALHRLWDELQATTKEKTQHLSAARSS 1381
Query: 1920 -WKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQ 1978
+LQ D + WI+ E L+++ G DL +LAK ++ +
Sbjct: 1382 DLRLQTHAD------------LNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQV- 1428
Query: 1979 SFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPL 2038
+ ++E L E+ + + +IE KR+ LLE +++L + L
Sbjct: 1429 NVRKEELGELFAQVPSMGEEGGDADLSIE-------KRFLDLLEPLGRRKKQLESSRAKL 1481
Query: 2039 QKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQAD 2098
Q + DL E W E+ + +L ++ K ++ +
Sbjct: 1482 QISRDLEDE--------TLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPR 1533
Query: 2099 FKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEM 2158
+ +L+ QQ+ + L+ +W L + R Q L ++
Sbjct: 1534 VEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRL--------RDANE 1585
Query: 2159 CQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218
Q++ +A WI E Y + + K+ L+ + R+Q+ ++ R + ++
Sbjct: 1586 AQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLAS 1645
Query: 2219 LGDNLEDA 2226
L A
Sbjct: 1646 RAQGLLSA 1653
Score = 208 bits (530), Expect = 5e-53
Identities = 197/977 (20%), Positives = 422/977 (43%), Gaps = 56/977 (5%)
Query: 10 VESSGPKVLETAEE-----IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64
V+ SG KV++ + + +R + + T + + R L Q F++DA
Sbjct: 1120 VKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAK- 1178
Query: 65 LGKWIMEKVNILTDKSY-----EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERF 119
+ IL+++ Y E P +++ + EA ++ + +E R++
Sbjct: 1179 ------QAEAILSNQEYTLAHLEPPDSLE-------AAEAGIRKFEDFLGSMENNRDKVL 1225
Query: 120 T---MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRA-------LKFQQYVQECAD 169
+ G+ E + ++++ L+ + + ++ A L+ Q ++Q C +
Sbjct: 1226 SPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQE 1285
Query: 170 ILEWIGDKEAIATSVELGEDWERTEVLHKKF---EDFQVELVAKEGRVVEVNQYANECAE 226
+ WI DK + TS ++ D R LH K+ + F EL + EG + ++ + +
Sbjct: 1286 LTLWINDK--LLTSQDVSYDEARN--LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMD 1341
Query: 227 ENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPV 286
E L+ K ++ W+ L+ ++ + LS A + + + +WI E
Sbjct: 1342 EKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQ 1401
Query: 287 LTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKE 346
L S+D GKDL + + K +E + V +++ EL A+ + I++
Sbjct: 1402 LRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFL 1461
Query: 347 DLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGE 406
DL+ + S KLQ S D ++ + W+ E+ + + T++ +
Sbjct: 1462 DLLEPLGRRKKQLESSRAKLQ-------ISRDLEDETLWVEERLPLAQSADYGTNLQTVQ 1514
Query: 407 VLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWD 466
+ + ++Q ++EI + R + + GQ LV A ++ E++ L ++W L E
Sbjct: 1515 LFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAA 1574
Query: 467 ERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFT 526
R ++ + +Y D+++ ++W+ QE ++ ++++ A +L++H + A
Sbjct: 1575 GRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVE 1634
Query: 527 AQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQK 586
I + A L+ H + E I ++ + L++ A R+R L+ L +
Sbjct: 1635 DYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQ 1694
Query: 587 LYEDSDDLKNWINKKKKLADDEDY-KDIQNLKSRVQKQQVFEKEL-AVNKTQLENIQKTG 644
L ++DDL+ WI++K+ +A + +D ++ K + F +E A+ + +++N+
Sbjct: 1695 LKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI 1754
Query: 645 QEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ--FENNAEDLQRW 702
+ +I+ GH + + + +W +LLE + QL A+ L F AE L
Sbjct: 1755 ERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTR-MQLLAASYDLHRYFYTGAEILG-- 1811
Query: 703 LEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSK 762
L D + + ED G + ++ R H E + QV D+A + +
Sbjct: 1812 LIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKA 1871
Query: 763 D-IRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYL 821
+ I+ +++ + ++AL + A R+ +L+D D +W++ +
Sbjct: 1872 EAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQER 1931
Query: 822 GKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNM 881
+D+ + + L+ H+ I I + E G +++ H A+E++ +++ +
Sbjct: 1932 PRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRR 1991
Query: 882 ESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKH 941
+ + + R L ++ Q+ D AE W+ +EP + + ++G ++ L+K+H
Sbjct: 1992 KEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRH 2051
Query: 942 EAFLLDLNSFGDSMKAL 958
EAF S+ + AL
Sbjct: 2052 EAFEKSTASWAERFAAL 2068
Score = 171 bits (433), Expect = 8e-42
Identities = 202/962 (20%), Positives = 402/962 (41%), Gaps = 74/962 (7%)
Query: 1298 ARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAEL-- 1355
A DL WI +++S++ A LTG++ L+ +R + P FQ + L
Sbjct: 311 ASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT--VEKPPKFQEKGNLEVLLFT 368
Query: 1356 IDSGHHASPEIEKKLQAVKLERDDLEKAWE-------------KRKKILDQCLE--LQMF 1400
I S A+ + KL D+ +AWE + + I + LE + F
Sbjct: 369 IQSRMRANNQKVYTPHDGKLV-SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRF 427
Query: 1401 QGNCDQVESWMVARENSLRSDDKS-SLDSLEALMKKRDDLDKAITAQEGKITDLEHFAES 1459
E+W+ + + D+ L ++EA KK + ++ A E ++ LE A+
Sbjct: 428 DRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQE 487
Query: 1460 LIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEM 1519
L + ++ ++ I R +L W L+ L R +L L++ ++D+ +W+ E+
Sbjct: 488 LEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEI 547
Query: 1520 LPTACDESY-KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIE---CSACDGNE 1575
+ K ++ KH+ ++ + ++V + E CD
Sbjct: 548 KAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCD--P 605
Query: 1576 EAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQ 1635
+ +++++ L++ ++ L + +L ++ R +F + + E W+ E E + + D
Sbjct: 606 QVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDY 665
Query: 1636 ARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRF 1695
+DL S L +KH+ E E+ + L+ + A +++ F QI + V+ ++
Sbjct: 666 GKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQW 725
Query: 1696 LNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKH 1755
+++LAA + L++A FQF D DD ++W+++ +S +D G+D + L KKH
Sbjct: 726 DQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKH 785
Query: 1756 KRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKL 1815
K EL ++++ A+ ++ ++ RL E ++++ A R +L
Sbjct: 786 KDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVVAQADLRQQRL 844
Query: 1816 EESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRV 1875
+E+L+ + E W+ EK + DTL + + + + L+ + T++
Sbjct: 845 QEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQI 904
Query: 1876 QNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNW 1935
V + V +++E+ + LN + + ++ + + D A + N+
Sbjct: 905 DGVNLAANSL---VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV--DSALRVHNY 959
Query: 1936 KADVVEA--WIADKETSLK-TNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLK 1992
D E WI DK ++ T G DL + + K L+ + + Q R+ +
Sbjct: 960 CVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAI-QARVDALERES 1018
Query: 1993 DKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKA 2052
+L+ + Q + I +R L + W+ L Q LQ EDL E +
Sbjct: 1019 QQLMDSHPEQKEDIGQRQKHLEELWQGL--------------QQSLQGQEDLLGEVSQLQ 1064
Query: 2053 SALNN------WCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELD 2106
+ L + W ++ ++ SL E QL + H + Q ++ + E
Sbjct: 1065 AFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESG 1124
Query: 2107 QQIKALGVPSSPYTWL--TVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQ 2164
+++ G Y L +E L+ W L + E R L Q F QEF++
Sbjct: 1125 EKV-IQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTL-----AQCLGF---QEFQK 1175
Query: 2165 NASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKI---VDLGD 2221
+A + IL + Y L + L+ +LE+ ++ + + +M+ K+ VD G+
Sbjct: 1176 DAKQ-AEAILSNQEYTL--AHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGN 1232
Query: 2222 NL 2223
L
Sbjct: 1233 KL 1234
Score = 164 bits (414), Expect = 1e-39
Identities = 204/1037 (19%), Positives = 417/1037 (40%), Gaps = 84/1037 (8%)
Query: 1365 EIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVAR--ENSLRSDD 1422
E EK ++ DL E+ +L+ G Q++++ R E + +
Sbjct: 299 ETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQE 358
Query: 1423 KSSLDSLEALMKKR--DDLDKAITAQEGK-ITDLEHFAESLIADEHYAKEEIATRLQRVL 1479
K +L+ L ++ R + K T +GK ++D+ ESL E+ + E+A R + +
Sbjct: 359 KGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEY--RRELALRNELI- 415
Query: 1480 DRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYK-DATNIQRKY 1538
+ KL A ++F R E W+SE +++ D ++
Sbjct: 416 ------------RQEKLEQLA--RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAK 461
Query: 1539 LKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTND 1598
KH+ + E+V + +L L + + D ++ + + + + W +L E
Sbjct: 462 KKHEAIETDTAAYEERVRALEDLAQELEKENYHD--QKRITARKDNILRLWSYLQELLQS 519
Query: 1599 KGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLA 1658
+ ++L Q+ + W+ E + L + + L +LL+KH+L+E ++
Sbjct: 520 RRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAI 579
Query: 1659 REDALKDLNTLAEDLLSSGTFNV--DQIVKKK-DNVNKRFLNVQELAAAHHEKLKEAYAL 1715
+ D +K + + Q+++ + ++ + F + +AA +L+++ L
Sbjct: 580 QGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRL 639
Query: 1716 FQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775
++FF ++D+ ESWI+EK SS DYG+DL V L +KHK E EL + ++ +
Sbjct: 640 WKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQE 699
Query: 1776 AEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWI 1835
A + + G +I+ R+ + W++LK+LA L+++ + QF +A++ +AW+
Sbjct: 700 AHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWL 759
Query: 1836 NEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQ 1895
+ + L D G AT++L KH+ DF + V E +E
Sbjct: 760 QDAHRLLSGEDVGQDEGATRALGKKHK----DFLEELEESRGVMEHLEQQAQGFPEEFRD 815
Query: 1896 NKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNG 1955
+ +++ +++AL E + + +L++ + D E W+ +KE L
Sbjct: 816 SPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEME 875
Query: 1956 NGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLK 2015
L D + + D LD +++ + + + + L+ + H +S+ +++ L
Sbjct: 876 MPDTLEDLEVVQHRFDILDQEMKTLMTQ-IDGVNLAANSLVESGHPRSREVKQYQDHLNT 934
Query: 2016 RWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEEN---LSEPVHC 2072
RW+ + R E A ++N+C EE +++
Sbjct: 935 RWQAFQTLVSERR------------------EAVDSALRVHNYCVDCEETSKWITDKTKV 976
Query: 2073 V--------SLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTV 2124
V L I +Q+ +A QA L QQ+ + S P
Sbjct: 977 VESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL----MDSHPE---QK 1029
Query: 2125 EVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGS 2184
E + + KHL ++ + +Q LQ +E + Q F Q+ F W+ T+
Sbjct: 1030 EDIGQRQKHLEELWQGLQQSLQGQE-DLLGEVSQLQAFLQDLDDFQAWLSITQKAVASED 1088
Query: 2185 LLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL----EDALILDIKYSTIGLAQ 2240
+ + E L+ + + EI + ++ + G+ + D L + GL
Sbjct: 1089 MPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDT 1148
Query: 2241 QWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCL 2300
W+ L ++ H L Q + ++ ++ K+ I + + L +
Sbjct: 1149 GWNALGRMWESRSHTLAQCLGFQEF----QKDAKQAEAILSNQEYTLAHLEPPDSLEAAE 1204
Query: 2301 RGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENA 2360
G+ + + E+ +K L VD G K Y+ DK E ++ ++
Sbjct: 1205 AGIRKFEDFLGSMENNR--DKVLSPVDSGNKLVAEGNLYS----DKIKEKVQLIEDRHRK 1258
Query: 2361 FQALAEGKSYITKEDMK 2377
A+ S + +++++
Sbjct: 1259 NNEKAQEASVLLRDNLE 1275
Score = 149 bits (377), Expect = 2e-35
Identities = 191/937 (20%), Positives = 367/937 (39%), Gaps = 66/937 (7%)
Query: 1266 ELNEAWEDLQGRTKDRKESLNEA--------QKFYLFLSKARDLQNWISSIGGMVSSQEL 1317
++N AWE L+ R+ +L Q F KA + W+S +V+
Sbjct: 391 DINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF 450
Query: 1318 AEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLER 1377
DL +E ++H+ D A +ALED + EL +H I + +
Sbjct: 451 GYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLW 510
Query: 1378 DDLEKAWEKRKKILDQCLELQ-MFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKR 1436
L++ + R++ L+ L LQ +FQ ++ + + L ++ L +E L++K
Sbjct: 511 SYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKH 570
Query: 1437 DDLDKAITAQEGKITDLEHFAESLIADEHYA---KEEIATRLQRVLDRWKALKAQLIDER 1493
++ I Q K+ + + Y + I R+ + ++ L +
Sbjct: 571 KLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRK 630
Query: 1494 TKLGDYANLKQFYRDLEELEEWISEMLPTACDESY-KDATNIQRKYLKHQTFAHEVDGRS 1552
+L L +F+ +++E E WI E Y KD T++ KH+ F E+ G
Sbjct: 631 AQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLD 690
Query: 1553 EQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRF 1612
+ + + ++ + ++ +++++ WD L + K L +A +F
Sbjct: 691 AHLEQIFQEAHGMV--ARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
Query: 1613 NTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAED 1672
D + WL +A LL+ +D +D + L KKH+ E+ ++ L A+
Sbjct: 749 QGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG 808
Query: 1673 LLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEK 1732
+ D + + + + + V A ++L+EA L+ F + D E W+ EK
Sbjct: 809 FPEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEK 867
Query: 1733 ---LIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEE 1789
L + D DL+ VQ+ + L+ E+ I V A L + E
Sbjct: 868 EKWLAEMEMPDTLEDLEVVQH---RFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
Query: 1790 IQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEK-NALAVRGDCG 1848
++ W+ + L R ++ +L + + EE WI +K + D G
Sbjct: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
Query: 1849 DTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNE 1908
LA ++ K LE D A + RV + + + +++ Q ++I + + L E
Sbjct: 985 RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD---SHPEQKEDIGQRQKHLEE 1041
Query: 1909 KTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLA 1968
L +++ + L + Q F D +AW++ + ++ + L + LL
Sbjct: 1042 LWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQ 1101
Query: 1969 K----QDTLDASLQSFQQERLPEITDLKDKLISAQHN--------QSKAIEERYAALLKR 2016
+ +D +D S+Q+ + + +K+I Q + + + ++ + AL +
Sbjct: 1102 QHAGIKDEIDGHQDSYQR-----VKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
Query: 2017 WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLN 2076
WE R L + L Q+ F + A +A A+ + E +L P SL
Sbjct: 1157 WES--------RSHTLAQCLGFQE----FQKDAKQAEAILSNQEYTLAHLEPP---DSLE 1201
Query: 2077 EIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSD 2136
+ EDFL S+ + ++ ++ A G S V+++E D
Sbjct: 1202 AAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIE-------D 1254
Query: 2137 IIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173
+ ++ Q+ N E+ Q F QN WI
Sbjct: 1255 RHRKNNEKAQEASVLLRDNLEL-QNFLQNCQELTLWI 1290
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 471 bits (1211), Expect = e-132
Identities = 357/1423 (25%), Positives = 669/1423 (47%), Gaps = 71/1423 (4%)
Query: 662 LSEVASLWEELLEATKQKGTQLH------EANQQL--QFENNAEDLQRWLEDVEWQVTSE 713
+S++ WE L EA ++ L E +QL +F+ A + WL + + V +
Sbjct: 389 VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448
Query: 714 DYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVC 773
++G LA V+ +KH +E+ AA +++V L DLA E+ + D K I AR+++++
Sbjct: 449 NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
Query: 774 RFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLN 833
+ L+E L +R+++L L LQ + +D W+ E + S GK L+ + LL
Sbjct: 509 LWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
Query: 834 RHRVILENIASHEPRIQEITERGNKMVEEGHFAAED---VASRVKSLNQNMESLRARAAR 890
+H+++ +IA +++ IT K E + D + R+ L Q E L AA
Sbjct: 569 KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
Query: 891 RQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNS 950
R+ LE + + ++ ++ EAE+WI+EKE I + +YG D + L +KH+AF +L
Sbjct: 629 RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
Query: 951 FGDSMKALRNQANAC-------QQQQAAPVEGVAGE---------------QRVMALYDF 988
++ + +A+ Q A ++ V+ + Q + F
Sbjct: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
Query: 989 QARSPREVTMKKGDVLTLLSS--INKDWWKVEAAD--HQGIVPAVYVRRLAHDEFPM--- 1041
Q + ++ D LLS + +D A H+ + + R +
Sbjct: 749 QGDAD-DLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQ 807
Query: 1042 -LPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQE 1100
P+ R+ P ++T R + + Y+ ++ +A+ R++RL + + + + E W+ E
Sbjct: 808 GFPEEFRDSP-DVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
Query: 1101 KKAENTGVELDDVWE----LQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQ 1156
K+ +E+ D E +Q +FD +++ T ++ +N A+ L+ G P +
Sbjct: 867 KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESG--HPRSRE 924
Query: 1157 IRQ---ELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQAL-SAADPG 1212
++Q LN+RW + Q L E+R+ + SA V + + ++T + I K + + S D G
Sbjct: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
Query: 1213 SDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWE 1272
DL + A+QR+ G ERD+ + +V L +++L +SHP+ ED+ +++ L E W+
Sbjct: 985 RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ 1044
Query: 1273 DLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQ 1332
LQ + +++ L E + FL D Q W+S V+S+++ E L E LL++H
Sbjct: 1045 GLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHA 1104
Query: 1333 EHRADMEAEAPTFQALEDFSAELIDSGHHASPE---IEKKLQAVKLERDDLEKAWEKRKK 1389
+ +++ ++Q +++ ++I PE + ++L+ + + L + WE R
Sbjct: 1105 GIKDEIDGHQDSYQRVKESGEKVIQG--QTDPEYLLLGQRLEGLDTGWNALGRMWESRSH 1162
Query: 1390 ILDQCLELQMFQGNCDQVESWMVARENSLRS-DDKSSLDSLEALMKKRDDLDKAITAQEG 1448
L QCL Q FQ + Q E+ + +E +L + SL++ EA ++K +D ++
Sbjct: 1163 TLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRD 1222
Query: 1449 KITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRD 1508
K+ L+A+ + ++I ++Q + DR + + + L D L+ F ++
Sbjct: 1223 KVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQN 1282
Query: 1509 LEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIEC 1568
+EL WI++ L T+ D SY +A N+ K+LKHQ F E+ + + G L++
Sbjct: 1283 CQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE 1342
Query: 1569 SACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAET 1628
+ ++LE L WD L T +K + L+ A + D W+S E
Sbjct: 1343 KP--QFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMED 1400
Query: 1629 LLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688
L D +DL S +L K + +E ++ R++ +L L + S G D +
Sbjct: 1401 QLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKE---ELGELFAQVPSMGEEGGDADL--- 1454
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748
++ KRFL++ E ++L+ + A Q +DL+DE W+EE+L S DYG +LQ V
Sbjct: 1455 -SIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTV 1513
Query: 1749 QNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELA 1808
Q +KK++ L+ E++ H P +++VL ++L + A + ++++ RL W++L+E A
Sbjct: 1514 QLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAA 1573
Query: 1809 KARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDF 1868
R +L ++ E Q+ +A+E EAWI E+ + + +L +H +
Sbjct: 1574 AGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAV 1633
Query: 1869 AVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDY 1928
+ ++ + ++ + +L+ E Q + +++ + L K +LE+ Y
Sbjct: 1634 EDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVD---KHYAGLKDVAEERKRKLENMY 1690
Query: 1929 AFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEI 1988
+ + D +E WI++KE + G D L K + QER+ +
Sbjct: 1691 HLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNV 1750
Query: 1989 TDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKL 2031
++LI A H+++ I E L + W LLE Q L
Sbjct: 1751 NAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLL 1793
Score = 428 bits (1101), Expect = e-119
Identities = 341/1378 (24%), Positives = 622/1378 (45%), Gaps = 72/1378 (5%)
Query: 23 EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY- 81
+I+ R +EV ++ K+ A + L+D+ + F+ DADDL W+ + +L+ +
Sbjct: 713 QIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVG 772
Query: 82 --EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHL 139
E T GK KH+ E++ +M LE+ + + F + ++ LR L
Sbjct: 773 QDEGATRALGK--KHKDFLEELEESRGVMEHLEQ-QAQGFPEEFRDSPDVTHRLQALREL 829
Query: 140 WDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKK 199
+ ++ + +L AL E W+G+KE +E+ + E EV+ +
Sbjct: 830 YQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHR 889
Query: 200 FEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKA 259
F+ E+ ++ VN AN E HP ++ Q+ +N W+ + L +R++A
Sbjct: 890 FDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREA 949
Query: 260 LSNAANLQRFKRDVTEAIQWIKEKEPVLTS-EDYGKDLVASEGLFHSHKGLERNLAVMSD 318
+ +A + + D E +WI +K V+ S +D G+DL + GLER++A +
Sbjct: 950 VDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
Query: 319 KVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSD 378
+V L ++++L SHP I + ++ L W+ ++ + + L F D
Sbjct: 1010 RVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQD 1069
Query: 379 FDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN 438
D+ W++ A+ ++++P + E LL +H K EID + D +Q E+G+ ++
Sbjct: 1070 LDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ 1129
Query: 439 ANHEASDEVR-EKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEA 497
+ + +++E LD W AL +W+ R QCL F F +D++Q ++ +S QE
Sbjct: 1130 GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEY 1189
Query: 498 FLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIR 557
L + + +SL +AEA ++K EDF + +K+++ + KL+ + + S+ IK
Sbjct: 1190 TLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKV 1249
Query: 558 DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLK 617
+ R EKA LL+++L LQ ++ +L WIN K + D Y + +NL
Sbjct: 1250 QLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLH 1309
Query: 618 SRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATK 677
++ K Q F ELA ++ LENI G+++++ + V+ +L + LW+EL TK
Sbjct: 1310 NKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTK 1369
Query: 678 QKGTQLHEA-NQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAV 736
+K L A + L+ + +A DL +W+ +E Q+ S+D GK L V L K +E V
Sbjct: 1370 EKTQHLSAARSSDLRLQTHA-DLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQV 1428
Query: 737 AARQDQV-DILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHL 795
R++++ ++ + + EE G D S+ RF L EPL RKK+L
Sbjct: 1429 NVRKEELGELFAQVPSMGEEGGDADL--------SIEKRFLDLLEPLGRRKKQLESSRAK 1480
Query: 796 QLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITER 855
I RD EDE W++E P A S G +L + + +++ + I H PR++++ +R
Sbjct: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
Query: 856 GNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWI 915
G ++VE +D+ R+ L + + LR AA R L + QQY D EAE WI
Sbjct: 1541 GQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600
Query: 916 REKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANAC------QQQQ 969
E+E V + DEE A +LK+H + +G ++K L ++A + +Q
Sbjct: 1601 GEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQ 1660
Query: 970 AAPVEGV----------AGEQRVMALYD----FQAR----------SPREVTMKKG---- 1001
++G E+R L + FQ + S +E+
Sbjct: 1661 IIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQ 1720
Query: 1002 --DVLTLLSSINKDWWKVEAADHQGIVPAV--YVRRLAHDEFPMLPQRRREEPGNITQRQ 1057
D +TLL +D+ + A Q V V ++ RL E I + +
Sbjct: 1721 DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLI--------DAGHSEAATIAEWK 1772
Query: 1058 EQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK---AENTGVELDDVW 1114
+ + + LL+ + R + L Y+ Y ++L I EK E+ G++
Sbjct: 1773 DGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAE 1832
Query: 1115 ELQKKFDEFQKDLNTNEPRLRDINKVADDL--LFEGLLTPEGAQIRQELNSRWGS-LQRL 1171
+ F+++L+ +++ VA L + G QE+++ W + L
Sbjct: 1833 SFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDAC 1892
Query: 1172 ADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERD 1231
A + QL+ +A F A D +E + + + D+ SV+ L + H+G +
Sbjct: 1893 AGRRTQLVDTADKFRFFSM-ARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAE 1951
Query: 1232 LVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKF 1291
+ + E E L + A+E+++ + ++ +++ + + R E L +
Sbjct: 1952 IETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEV 2011
Query: 1292 YLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALE 1349
F A + W+ + ++S + + +E L++RH+ + A F ALE
Sbjct: 2012 CQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALE 2069
Score = 373 bits (958), Expect = e-102
Identities = 331/1490 (22%), Positives = 641/1490 (43%), Gaps = 87/1490 (5%)
Query: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY-E 82
IQ+R + ++ A R +LE S L F + D+ WI EK I + Y +
Sbjct: 608 IQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGK 667
Query: 83 DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDL 142
D T++ +KH++ E E++ + ++ + H + +A I+E+ WD
Sbjct: 668 DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQ 727
Query: 143 LLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFED 202
L +L L A F Q+ + D+ W+ D + + ++G+D T L KK +D
Sbjct: 728 LKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKD 787
Query: 203 FQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSN 262
F EL G + + Q A EE D P + + + ++++ A RQ+ L
Sbjct: 788 FLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVVAQADLRQQRLQE 846
Query: 263 AANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKE 322
A +L + W+ EKE L + L E + H L++ + + ++
Sbjct: 847 ALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDG 906
Query: 323 LCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDEL 382
+ A L S + ++++ ++ L + W+ + L + R E + + H + D +E
Sbjct: 907 VNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEET 966
Query: 383 SGWMNEKTAAINAD-ELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANH 441
S W+ +KT + + +L D+AG + + + ++ + R + + Q L++++
Sbjct: 967 SKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
Query: 442 EASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLEN 501
E +++ ++ + L+ W L + + + F +D + +W+S + + +
Sbjct: 1027 EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS 1086
Query: 502 EDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLI-GDDHYDSENIKAIRDGL 560
ED+ SL AE LLQ+H ++ ++ V ++ K+I G + + +GL
Sbjct: 1087 EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGL 1146
Query: 561 LARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWI-NKKKKLADDEDYKDIQNLKSR 619
+AL +R L + L Q+ +D+ + + N++ LA E ++ ++
Sbjct: 1147 DTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAG 1206
Query: 620 VQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQK 679
++K + F + N+ ++ + +G +++ G+ SD + ++ + + E ++
Sbjct: 1207 IRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEA 1266
Query: 680 GTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAE-VQNRLRKHGLLESAVAA 738
L + + F N ++L W+ D +TS+D A + N+ KH + +A+
Sbjct: 1267 SVLLRDNLELQNFLQNCQELTLWINDK--LLTSQDVSYDEARNLHNKWLKHQAFVAELAS 1324
Query: 739 RQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLI 798
+ ++ + + + + + E+L ++ L+ + + L L
Sbjct: 1325 HEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR 1384
Query: 799 CRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNK 858
+ D WI E S GKDL + ++L + + + + + + + E+ +
Sbjct: 1385 LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPS 1444
Query: 859 MVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREK 918
M EEG A + R L + + RR+ LE++ Q DL + W+ E+
Sbjct: 1445 MGEEGGDADLSIEKRFLDLLEPL-------GRRKKQLESSRAKLQISRDLEDETLWVEER 1497
Query: 919 EPIVDNTNYGADEEAAGALLKKH-------------------------EAFLLDLNSFGD 953
P+ + +YG + + +KK+ EA +D +
Sbjct: 1498 LPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEE 1557
Query: 954 SMKALRNQ-----------------ANACQQQ--QAAPVEGVAGEQRVMALYDFQARSPR 994
+ L++ AN QQ A E GEQ + + D
Sbjct: 1558 RLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISD------- 1610
Query: 995 EVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNIT 1054
E+ + + +L + VE +++LA +L E I
Sbjct: 1611 EIPKDEEGAIVMLKRHLRQQRAVEDYGRN-------IKQLASRAQGLL-SAGHPEGEQII 1662
Query: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----AENTGVEL 1110
+ Q Q++ Y L D AEER+R+L Y+ F L E D+ +WI EK+ + G +
Sbjct: 1663 RLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDF 1722
Query: 1111 DDVWELQKKFDEFQKDLNT-NEPRLRDINKVADDLLFEGLLTPEGAQI---RQELNSRWG 1166
D V L+ KF +F ++ + R+ ++N + L+ G E A I + LN W
Sbjct: 1723 DHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAG--HSEAATIAEWKDGLNEMWA 1780
Query: 1167 SLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHE 1226
L L D + QLL +++ + + + I++K + L D G D + ++ R H
Sbjct: 1781 DLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPE-DVGLDASTAESFHRVHT 1839
Query: 1227 GFERDLVPLGDKVTILGETAERLSESHP-DATEDLQRQKMELNEAWEDLQGRTKDRKESL 1285
FER+L LG +V + A RL ++ + E +Q ++ E++ AW+ L R+ L
Sbjct: 1840 AFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQL 1899
Query: 1286 NEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTF 1345
+ + F S ARDL +W+ SI + +QE D++ +E+L++ HQ A++E + F
Sbjct: 1900 VDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
Query: 1346 QALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCD 1405
A + L+ H AS EI +KLQ V R ++ + WE R + L LE+ F +
Sbjct: 1960 SACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDAS 2019
Query: 1406 QVESWMVARENSLRSDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDLE 1454
E+W++A+E L S D ++DS+E L+K+ + +K+ + + LE
Sbjct: 2020 VAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALE 2069
Score = 367 bits (942), Expect = e-101
Identities = 373/1695 (22%), Positives = 735/1695 (43%), Gaps = 90/1695 (5%)
Query: 240 NEVNAAWERLRGLALQRQKALSNAANLQ--------RFKRDVTEAIQWIKEKEPVLTSED 291
+++N AWE L +R+ AL N Q RF R W+ E + ++ ++
Sbjct: 390 SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDN 449
Query: 292 YGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSS 351
+G DL A E H+ +E + A ++V+ L A++L + D +I K++++
Sbjct: 450 FGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRL 509
Query: 352 WEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411
W +++ L SR ++L+ T + D WM+E A + + E + E LL +
Sbjct: 510 WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQK 569
Query: 412 HQQHKHEIDSYDDRFQSADETGQDLVNAN-HEASDE--VREKMEILDNNWTALLELWDER 468
H+ + +I D+ ++ ++ D +++++ L+ + L + R
Sbjct: 570 HKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGR 629
Query: 469 HRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQ 528
Q EQ F+ + ++ +SW+ +E + D G L S L +KH+ FE+
Sbjct: 630 KAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGL 689
Query: 529 EEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLY 588
+ + + + A ++ + I+A + A+ D L++ AA ++ L+++ +
Sbjct: 690 DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQ 749
Query: 589 EDSDDLKNWINKKKKLADDEDY-KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEM 647
D+DDLK W+ +L ED +D ++ +K + F +EL ++ +E++++ Q
Sbjct: 750 GDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF 809
Query: 648 IEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQF--ENNAEDL-----Q 700
E + D VT RL + L+++++ + +L EA E +A +L +
Sbjct: 810 PEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKE 868
Query: 701 RWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPD 760
+WL ++E T ED L VQ+R +L+ + Q+D + A E GHP
Sbjct: 869 KWLAEMEMPDTLED----LEVVQHRF---DILDQEMKTLMTQIDGVNLAANSLVESGHPR 921
Query: 761 SKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY 820
S++++ Q+ L R++A + ++ R++ + L + C D E+ WI + ST
Sbjct: 922 SREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK 981
Query: 821 -LGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQ 879
LG+DL + + + ++A+ + R+ + ++++ ED+ R K L +
Sbjct: 982 DLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEE 1041
Query: 880 NMESLRARAARRQNDLEANV-QFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALL 938
+ L+ ++ + Q DL V Q Q +L DL + + W+ + V + + A LL
Sbjct: 1042 LWQGLQ-QSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLL 1100
Query: 939 KKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQ------------------ 980
++H +++ DS + ++ Q Q P + G++
Sbjct: 1101 QQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESR 1160
Query: 981 -----RVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLA 1035
+ + +FQ + + + TL D + A + +
Sbjct: 1161 SHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENN 1220
Query: 1036 HDEF--PMLPQRRREEPGN-----ITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLA 1088
D+ P+ + GN I ++ + IE+++R ++A+E L
Sbjct: 1221 RDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFL 1280
Query: 1089 YEAGDMLEWIQEKKAENTGVELDDVWELQKKF---DEFQKDLNTNEPRLRDINKVADDLL 1145
++ WI +K + V D+ L K+ F +L ++E L +I+ L+
Sbjct: 1281 QNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLM 1340
Query: 1146 FEG-LLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQ 1204
E T +Q + L+ W LQ E+ Q L +A + ++ + D + I
Sbjct: 1341 DEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMED 1400
Query: 1205 ALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQK 1264
L + DPG DL SV + + + E + +++ L + E DA ++++
Sbjct: 1401 QLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRF 1460
Query: 1265 MELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQN---WISSIGGMVSSQELAEDL 1321
++L E GR K + ES L +RDL++ W+ + S + +L
Sbjct: 1461 LDLLEPL----GRRKKQLESSRAK------LQISRDLEDETLWVEERLPLAQSADYGTNL 1510
Query: 1322 TGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLE 1381
+++ ++++Q + ++ P + + +L+++ ++E++L ++ D L
Sbjct: 1511 QTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLR 1570
Query: 1382 KAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDK 1441
+A R + L E Q + + D+ E+W+ +E + SD+ + +M KR +
Sbjct: 1571 EAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQ 1630
Query: 1442 AITAQEGK-ITDLEHFAESLIADEHYAKEEIATRLQRVLDR-WKALKAQLIDERTKLGDY 1499
G+ I L A+ L++ H E+I RLQ +D+ + LK + + KL +
Sbjct: 1631 RAVEDYGRNIKQLASRAQGLLSAGHPEGEQII-RLQGQVDKHYAGLKDVAEERKRKLENM 1689
Query: 1500 ANLKQFYRDLEELEEWISEM-LPTACDESYKDATNIQRKYLKHQTFAHEVDG-RSEQVHG 1557
+L Q R+ ++LE+WISE L + E +D ++ K + FA E E+V
Sbjct: 1690 YHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDN 1749
Query: 1558 VINLGNSLIECSACDGNEEA--MKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTS 1615
V N+ IE G+ EA + E + L E W LLE + + + L + R+ +
Sbjct: 1750 V----NAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYT 1805
Query: 1616 IRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLS 1675
+ + E L +D D ++A + + H ERE+ ++ +A L +
Sbjct: 1806 GAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQT 1864
Query: 1676 S-GTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLI 1734
+ + I K+ V+ + + + A +L + F+FF D SW+E +
Sbjct: 1865 AYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIR 1924
Query: 1735 RVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRL 1794
++ +Q+ RD+ V+ L+K H+ + E+ L++ E L + EEI+ +L
Sbjct: 1925 QIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKL 1984
Query: 1795 AQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAAT 1854
Q + +++ E +AR +L LE QF ++A EAW+ + GD G T+ +
Sbjct: 1985 QQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSV 2044
Query: 1855 QSLLMKHEALENDFA 1869
+ L+ +HEA E A
Sbjct: 2045 EKLIKRHEAFEKSTA 2059
Score = 362 bits (929), Expect = 2e-99
Identities = 341/1698 (20%), Positives = 712/1698 (41%), Gaps = 72/1698 (4%)
Query: 5 PKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64
P + + S + E+ EE + RR+ L +E++ + ++ F R A
Sbjct: 383 PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---------FDRKAAM 433
Query: 65 LGKWIMEKVNILTDKSYE-DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGH 123
W+ E ++ ++ D ++ +KH+++E + + LE +E +
Sbjct: 434 RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493
Query: 124 SAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATS 183
+ A + + LW L EL + +L L Q+ Q+ ++W+ + +A S
Sbjct: 494 HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLS 553
Query: 184 VELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEEN--HP-DLPLIQSKQN 240
E G+ E L +K + + ++ + +V + + E P D +IQ + +
Sbjct: 554 AEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRIS 613
Query: 241 EVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASE 300
+ +E L +A R+ L + L +F ++ EA WIKEKE + +S DYGKDL +
Sbjct: 614 HLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVL 673
Query: 301 GLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALAT 360
L HK E L + ++++ +A + PQI+ +++ + W+ ++ LA
Sbjct: 674 ILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAA 733
Query: 361 SRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEID 420
+ LQ + +F D D+L W+ + ++ +++ D L +H+ E++
Sbjct: 734 FCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793
Query: 421 SYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHL 480
+ ++ Q ++ D V +++ L + ++ D R ++ ++ LD +
Sbjct: 794 ESRGVMEHLEQQAQGFPEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEALDLYT 852
Query: 481 FYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTAT 540
+ +++ + WM +E +L ++ ++L E + + + ++ +I V+ A
Sbjct: 853 VFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAAN 912
Query: 541 KLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINK 600
L+ H S +K +D L R A + + RR + +L + D ++ WI
Sbjct: 913 SLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITD 972
Query: 601 KKKLADD--EDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNV 658
K K+ + + +D+ + + +K E+++A + +++ +++ Q++++ +++
Sbjct: 973 KTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
Query: 659 TTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKG 718
R + LW+ L ++ + + L E +Q F + +D Q WL + V SED +
Sbjct: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPES 1092
Query: 719 LAEVQNRLRKHGLLESAVAARQDQVDILTDLA-AYFEEIGHPDSKDIRARQESLVCRFEA 777
L E + L++H ++ + QD + + + P+ + R E L + A
Sbjct: 1093 LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNA 1152
Query: 778 LKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRV 837
L +R L L Q +D + EA + E + L A++ + +
Sbjct: 1153 LGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFED 1212
Query: 838 ILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEA 897
L ++ ++ ++ + GNK+V EG+ ++ + +V+ + +A L
Sbjct: 1213 FLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRD 1272
Query: 898 NVQFQQYLADLHEAETWIREKEPIVDNTNYG---------ADEEAAGALLKKHEAFLLDL 948
N++ Q +L + E WI +K + +Y +A A L HE +L ++
Sbjct: 1273 NLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENI 1332
Query: 949 NSFGDSMKALRNQANACQQQQAAPVEGVAGE---------QRVMALYDFQAR-------- 991
++ G + + Q A Q+ + + E Q + A R
Sbjct: 1333 DAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLN 1392
Query: 992 ---SPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRRE 1048
S E ++ D L+S+N+ K++ + Q V VR+ E E
Sbjct: 1393 KWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQ-----VNVRKEELGELFAQVPSMGE 1447
Query: 1049 EPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEK----KAE 1104
E G+ IE ++ LL+ R+++L + ++ + D W++E+ ++
Sbjct: 1448 EGGD---ADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSA 1504
Query: 1105 NTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR-QELNS 1163
+ G L V KK Q ++ + PR+ D+ + L+ + + + R L S
Sbjct: 1505 DYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQS 1564
Query: 1164 RWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQI-EKKCQALSAADPGSDLFSVQALQ 1222
W L+ A + Q L A+ + ++ +AD+ + I E++ +S P + ++ L
Sbjct: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVML- 1623
Query: 1223 RRHEGFERDLVPLGDKVTILGETAE-RLSESHPDATEDLQRQKMELNEAWEDLQGRTKDR 1281
+RH +R + G + L A+ LS HP+ E + R + ++++ + L+ ++R
Sbjct: 1624 KRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEG-EQIIRLQGQVDKHYAGLKDVAEER 1682
Query: 1282 KESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEA- 1340
K L + + DL+ WIS + SS E+ +D + +L ++ ++ + A
Sbjct: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAI 1742
Query: 1341 EAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMF 1400
+ F LID+GH + I + + DL + + R ++L +L +
Sbjct: 1743 GQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRY 1802
Query: 1401 QGNCDQVESWMVARENSLRSD---DKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFA 1457
++ + + L D D S+ +S + + + Q + D+
Sbjct: 1803 FYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRL 1862
Query: 1458 ESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWIS 1517
++ A E E I + Q V W+AL RT+L D A+ +F+ +L W+
Sbjct: 1863 QTAYAGE--KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME 1920
Query: 1518 EML-PTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE 1576
++ E +D ++++ HQ E++ RS+ + LG SL++ E
Sbjct: 1921 SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ--HQASE 1978
Query: 1577 AMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQA 1636
++E+L+Q+ + E+ + ++L +F+ E WL E LA D
Sbjct: 1979 EIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFG 2038
Query: 1637 RDLASAGNLLKKHQLLER 1654
+ S L+K+H+ E+
Sbjct: 2039 HTVDSVEKLIKRHEAFEK 2056
Score = 328 bits (842), Expect = 3e-89
Identities = 373/1839 (20%), Positives = 739/1839 (40%), Gaps = 131/1839 (7%)
Query: 259 ALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEG---LFHSHKGLER---- 311
A+ ++++ ++ + WI++ VL S + L + F +++ +E+
Sbjct: 297 AIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKF 356
Query: 312 ----NLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKE--DLVSSWEHIRALATS---- 361
NL V+ ++ +A + P D + ++ + + E+ R LA
Sbjct: 357 QEKGNLEVLLFTIQSRM-RANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI 415
Query: 362 RYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDS 421
R EKL+ RF W++E + D D+A E +H+ + + +
Sbjct: 416 RQEKLEQLA--RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAA 473
Query: 422 YDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLF 481
Y++R ++ ++ Q+L N+ + + + + W+ L EL R ++ E L
Sbjct: 474 YEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKL 533
Query: 482 YRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATK 541
++D WM +A L + + G L E LLQKH+ E Q +K+ + K
Sbjct: 534 FQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLK 593
Query: 542 LIGDDHYDSENIKAIRDGLLARRDALRE---KAATRRRLLKESLLLQKLYEDSDDLKNWI 598
Y + + I+D + E AA R+ L++S L K + + D+ ++WI
Sbjct: 594 FTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWI 653
Query: 599 NKKKKLADDEDY-KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDN 657
+K+++ DY KD+ ++ +K + FE EL LE I + M+ +
Sbjct: 654 KEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQ 713
Query: 658 VTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGK 717
+ R+ EV++ W++L + L +A QF+ +A+DL+ WL+D ++ ED G+
Sbjct: 714 IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773
Query: 718 GLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEA 777
+ +KH + + ++ L A F E DS D+ R ++L ++
Sbjct: 774 DEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPE-EFRDSPDVTHRLQALRELYQQ 832
Query: 778 LKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRV 837
+ R+++L + L L + +T+ E W+ E E + L + + +R +
Sbjct: 833 VVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDI 892
Query: 838 ILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEA 897
+ + + + +I + N +VE GH + +V LN ++ + + R+ +++
Sbjct: 893 LDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDS 952
Query: 898 NVQFQQYLADLHEAETWIREKEPIVDNT-NYGADEEAAGALLKKHEAFLLDLNSFGDSMK 956
++ Y D E WI +K +V++T + G D A+ +K D+ + +
Sbjct: 953 ALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVD 1012
Query: 957 ALRNQANACQQQQAAPVEGVAGEQRVMA-LYDFQARSPREVTMKKGDVLTLLSSINKDWW 1015
AL ++ E + Q+ + L+ +S + G+V L + +
Sbjct: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQ---- 1068
Query: 1016 KVEAADHQGIVPAVYVRRLAHDEFP-MLPQ----------------------RRREEPGN 1052
+ D Q + ++ + +A ++ P LP+ +R +E G
Sbjct: 1069 --DLDDFQAWL-SITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGE 1125
Query: 1053 -------------ITQRQEQIENQYRSLLDRAEERRRRLLQ--RYNEFLLAYEAGDMLEW 1097
+ QR E ++ + +L E R L Q + EF + + +
Sbjct: 1126 KVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILS 1185
Query: 1098 IQEKKAENTGVELDDVWELQ----KKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPE 1153
QE + +E D E +KF++F + N ++ + L+ EG L +
Sbjct: 1186 NQEYTLAH--LEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSD 1243
Query: 1154 GAQIRQEL-NSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPG 1212
+ + +L R A E LL ++ F + + I K L++ D
Sbjct: 1244 KIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL--LTSQDVS 1301
Query: 1213 SD-LFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAW 1271
D ++ +H+ F +L + + ++L + P T + ++ L+ W
Sbjct: 1302 YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLW 1361
Query: 1272 EDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERH 1331
++LQ TK++ + L+ A+ L L DL WIS++ + S + +DLT + +L +
Sbjct: 1362 DELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
Query: 1332 QEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKIL 1391
+ + L + + G A IEK+ DL + +RKK L
Sbjct: 1422 KRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFL-------DLLEPLGRRKKQL 1474
Query: 1392 DQCLELQMFQGNCDQVESWMVARENSLRSDDK-SSLDSLEALMKKRDDLDKAITAQEGKI 1450
+ + + W+ R +S D ++L +++ MKK L I ++
Sbjct: 1475 ESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRV 1534
Query: 1451 TDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLE 1510
D+ + L+ +++ RL + W L+ +L D +Q+Y D +
Sbjct: 1535 EDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDAD 1594
Query: 1511 ELEEWISEM-LPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECS 1569
E E WI E L DE KD +H V+ + + + L+
Sbjct: 1595 EAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAG 1654
Query: 1570 ACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETL 1629
+G E+ ++ Q Q+ +H+ L + ++ +KL + D E W+SE E +
Sbjct: 1655 HPEG-EQIIRLQ-GQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELV 1712
Query: 1630 LAMKDQARDLASAGNLLKKHQLLEREMLA-REDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688
+ + +D L K + RE A ++ + ++N E L+ +G I + K
Sbjct: 1713 ASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWK 1772
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748
D +N+ + ++ EL + L +Y L ++F + I+EK R +D G D
Sbjct: 1773 DGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKH-RELPEDVGLDASTA 1831
Query: 1749 QNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDK-AAVGQEEIQLRLAQFVEHWEKLKEL 1807
++ + H E EL +Q D+A +L+ A E IQ + + W+ L +
Sbjct: 1832 ESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDA 1891
Query: 1808 AKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALEND 1867
R +L ++ + +F A + +W+ + +++ + L+ H+ + +
Sbjct: 1892 CAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAE 1951
Query: 1868 FAVHETRVQNVCA--------------QGEDILNKVLQEESQNKEISSKIEALNEKTPSL 1913
ETR +N A E+I K+ Q S+ KE++ K EA E+ L
Sbjct: 1952 I---ETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRML 2008
Query: 1914 AKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTL 1973
+ +F+ A V EAW+ +E L + G + L+ + +
Sbjct: 2009 LEVC--------------QFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAF 2054
Query: 1974 DASLQSFQQE----RLPEITDLKDKLISAQHNQSKAIEE 2008
+ S S+ + P +LK++ I+ + + +E
Sbjct: 2055 EKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQE 2093
Score = 270 bits (689), Expect = 2e-71
Identities = 197/857 (22%), Positives = 385/857 (44%), Gaps = 27/857 (3%)
Query: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKS 80
+++I+E+ Q + R++ E+ E L D+ LQ F ++ +L WI +K+ D S
Sbjct: 1242 SDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS 1301
Query: 81 YEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLW 140
Y++ N+ K+ KHQ+ AE+ + + ++ ++ +E L LW
Sbjct: 1302 YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLW 1361
Query: 141 DLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKF 200
D L T EK L A +Q AD+ +WI E S + G+D
Sbjct: 1362 DELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVN------ 1415
Query: 201 EDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWER-----LRGLALQ 255
++AK RV + E E +P + + + + + E+ L L +
Sbjct: 1416 -----RMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRR 1470
Query: 256 RQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAV 315
+++ S+ A LQ RD+ + W++E+ P+ S DYG +L + ++ L+ +
Sbjct: 1471 KKQLESSRAKLQ-ISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
Query: 316 MSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRF 375
+ +V+++ + ++L + D ++E L SSW+ +R A R ++L+ ++
Sbjct: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQY 1589
Query: 376 SSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQD 435
D DE W+ E+ + +DE+P D G V+L RH + + ++ Y + Q
Sbjct: 1590 YLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQG 1649
Query: 436 LVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFY--RDSEQVDSWMS 493
L++A H +++ +D ++ L ++ +ER R+ E +HLF R+++ ++ W+S
Sbjct: 1650 LLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENM--YHLFQLKRETDDLEQWIS 1707
Query: 494 RQEAFLENEDLGNSLGSAEALLQKHEDF-EEAFTAQEEKIITVDKTATKLIGDDHYDSEN 552
+E + ++G L K DF E +E++ V+ +LI H ++
Sbjct: 1708 EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAAT 1767
Query: 553 IKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD 612
I +DGL L E TR +LL S L + + ++ I++K + ++ D
Sbjct: 1768 IAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLD 1827
Query: 613 IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDN---VTTRLSEVASLW 669
+S + FE+EL + Q++ Q + YA + + + EV++ W
Sbjct: 1828 ASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTA--YAGEKAEAIQNKEQEVSAAW 1885
Query: 670 EELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729
+ LL+A + TQL + + +F + A DL W+E + Q+ +++ + ++ V+ ++ H
Sbjct: 1886 QALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYH 1945
Query: 730 GLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKL 789
+ + + R +L + H S++IR + + ++ R + + E R ++L
Sbjct: 1946 QGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERL 2005
Query: 790 LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849
LL + RD EAW+ EP S G + + +KL+ RH ++ AS R
Sbjct: 2006 RMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERF 2065
Query: 850 QEITERGNKMVEEGHFA 866
+ + ++E A
Sbjct: 2066 AALEKPTTLELKERQIA 2082
Score = 244 bits (623), Expect = 7e-64
Identities = 285/1461 (19%), Positives = 593/1461 (40%), Gaps = 94/1461 (6%)
Query: 691 QFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQ-------- 742
++ A DL W+E + S + L VQ +L+ + + Q
Sbjct: 306 KYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVL 365
Query: 743 -VDILTDLAAYFEEIGHP-DSK---DIRARQESL----VCRFEALKEPLATRKKKLLDLL 793
I + + A +++ P D K DI ESL R AL+ L R++KL L
Sbjct: 366 LFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI-RQEKLEQLA 424
Query: 794 HLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEIT 853
+ R E W+ E + G DL A + +H I + A++E R++ +
Sbjct: 425 --RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALE 482
Query: 854 ERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAET 913
+ ++ +E + + + +R ++ + L+ R+ LE + Q+ D+ +
Sbjct: 483 DLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSID 542
Query: 914 WIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQA-AP 972
W+ E + + + +G LL+KH+ D+ GD +KA+ + + P
Sbjct: 543 WMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQP 602
Query: 973 VEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAA------------ 1020
+ + R+ L +K L + K +W+++ A
Sbjct: 603 CDPQVIQDRISHLEQCFEELSNMAAGRKAQ-LEQSKRLWKFFWEMDEAESWIKEKEQIYS 661
Query: 1021 --DHQGIVPAVYVRRLAHDEFP--------MLPQRRREEPGNITQRQ----------EQI 1060
D+ + +V + + H F L Q +E G + ++Q +++
Sbjct: 662 SLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEV 721
Query: 1061 ENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEK----KAENTGVELDDVWEL 1116
Q+ L D A ++ L N F +A D+ W+Q+ E+ G + L
Sbjct: 722 SAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRAL 781
Query: 1117 QKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQR 1176
KK +F ++L + + + + A E +P+ Q L + + AD ++
Sbjct: 782 GKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQ 841
Query: 1177 QLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLG 1236
Q L A + E D + + +K + L+ + L ++ +Q R + ++++ L
Sbjct: 842 QRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLM 901
Query: 1237 DKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLS 1296
++ + A L ES + ++++ + LN W+ Q +R+E+++ A + + +
Sbjct: 902 TQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCV 961
Query: 1297 KARDLQNWISSIGGMV-SSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAEL 1355
+ WI+ +V S+++L DL GI + + D+ A ALE S +L
Sbjct: 962 DCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL 1021
Query: 1356 IDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARE 1415
+DS +I ++ + ++ L+++ + ++ +L + +LQ F + D ++W+ +
Sbjct: 1022 MDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ 1081
Query: 1416 NSLRSDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLI---ADEHYAKEEI 1471
++ S+D SL E L+++ + I + ++ E +I D Y +
Sbjct: 1082 KAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLL--L 1139
Query: 1472 ATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDA 1531
RL+ + W AL L ++F +D ++ E +S T D+
Sbjct: 1140 GQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS 1199
Query: 1532 TNIQRKYL-KHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGN--EEAMKEQLEQLKEH 1588
+ K + F ++ ++V ++ GN L+ +GN + +KE+++ +++
Sbjct: 1200 LEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLV----AEGNLYSDKIKEKVQLIEDR 1255
Query: 1589 WDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLA-SAGNLLK 1647
E+ + L + Q F + ++ W++ + LL +D + D A + N
Sbjct: 1256 HRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWIN--DKLLTSQDVSYDEARNLHNKWL 1313
Query: 1648 KHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHE 1707
KHQ E+ + E L++++ + L+ + +K + +++ + +Q +
Sbjct: 1314 KHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQ 1373
Query: 1708 KLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEP 1767
L A + Q D WI ++ S D G+DL V +L K KR+E ++ +
Sbjct: 1374 HLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKE 1433
Query: 1768 AIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQN 1827
+ + + ++ I+ R +E + K+ +LE S LQ ++
Sbjct: 1434 ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKK-------QLESSRAKLQISRD 1486
Query: 1828 AEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILN 1887
E+E W+ E+ LA D G L Q + K++ L+N+ H RV++V +G+ ++
Sbjct: 1487 LEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVE 1546
Query: 1888 KVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADK 1947
E +++ ++ L L +A A +L D Q++ AD EAWI ++
Sbjct: 1547 AA---EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQ 1603
Query: 1948 ETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIE 2007
E + ++ D + +L + +++ + + + ++ L+SA H + + I
Sbjct: 1604 ELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGR-NIKQLASRAQGLLSAGHPEGEQII 1662
Query: 2008 ERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLS 2067
+ K + L + + ++K L+ LF + + L W + E S
Sbjct: 1663 RLQGQVDKHYAGLKDVAEERKRK-------LENMYHLF-QLKRETDDLEQWISEKELVAS 1714
Query: 2068 EPVHCVSLNEIRQLQKDHEDF 2088
P + + L+ DF
Sbjct: 1715 SPEMGQDFDHVTLLRDKFRDF 1735
Score = 241 bits (614), Expect = 8e-63
Identities = 265/1344 (19%), Positives = 527/1344 (39%), Gaps = 106/1344 (7%)
Query: 15 PKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVN 74
P+ + ++ R Q + YQ + R Q+L+++ L + D W+ EK
Sbjct: 810 PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEK 869
Query: 75 ILTDKSYEDPT-NIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHI 133
L + D +++ + L+ E++T + + GH E K +
Sbjct: 870 WLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQ 929
Query: 134 EELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSV-ELGEDWER 192
+ L W L E+ + + AL+ Y +C + +WI DK + S +LG D
Sbjct: 930 DHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAG 989
Query: 193 TEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGL 252
+ +K + ++ A + RV + + + + + + I +Q + W+ L+
Sbjct: 990 IIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQS 1049
Query: 253 ALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERN 312
++ L + LQ F +D+ + W+ + + SED + L +E L H G++
Sbjct: 1050 LQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDE 1109
Query: 313 LAVMSDKVKELCAKAEKLTLSHPS-DAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYW 371
+ D + + EK+ + + + E L + W + + SR L
Sbjct: 1110 IDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLG 1169
Query: 372 YHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADE 431
+ F D + ++ + + E P + E + + + +++ D+ S +
Sbjct: 1170 FQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVD 1229
Query: 432 TGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSW 491
+G LV + SD+++EK++++++ E E L+ F ++ +++ W
Sbjct: 1230 SGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLW 1289
Query: 492 MSRQEAFLENEDLG-NSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDS 550
++ + L ++D+ + + KH+ F + E + +D +L+ + +
Sbjct: 1290 IN--DKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFT 1347
Query: 551 ENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKK-KLADDED 609
+ + L D L+ + + L + + DL WI+ + +L D+
Sbjct: 1348 ALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDP 1407
Query: 610 YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLW 669
KD+ ++ + K + E ++ V K +L + M E G A ++ R +
Sbjct: 1408 GKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLD----- 1462
Query: 670 EELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729
LLE ++ QL + +LQ + ED W+E+ S DYG L VQ ++K+
Sbjct: 1463 --LLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKN 1520
Query: 730 GLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKL 789
L++ + +V+ + E D +D+ R L ++ L+E A R ++L
Sbjct: 1521 QTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRL 1580
Query: 790 LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849
D Q D ++ EAWI E E S + KD + +L RH + + I
Sbjct: 1581 RDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNI 1640
Query: 850 QEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLH 909
+++ R ++ GH E + ++++ L+ A R+ LE Q +
Sbjct: 1641 KQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD 1700
Query: 910 EAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFG----DSMKALRNQANAC 965
+ E WI EKE + + G D + L K F + + G D++ A +
Sbjct: 1701 DLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDA 1760
Query: 966 QQQQAAPV----EGV------------AGEQRVMALYDFQA-------------RSPREV 996
+AA + +G+ Q + A YD RE+
Sbjct: 1761 GHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHREL 1820
Query: 997 TMKKGDVLTLLSSINKDWWKVEAADHQGI-VPAVYVRRLAHDEFPMLPQRRREEPGNITQ 1055
G L +S + + +V A + + + V V++ + E+ I
Sbjct: 1821 PEDVG----LDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQN 1876
Query: 1056 RQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWI---------QEKKAENT 1106
+++++ +++LLD RR +L+ ++F A D+L W+ QE+ + +
Sbjct: 1877 KEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVS 1936
Query: 1107 GVELDDVW------ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE 1160
VEL + E++ + F L E L+ ++ ++++ + + R+E
Sbjct: 1937 SVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREK---LQQVMSRRKE 1993
Query: 1161 LNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQA 1220
+N +W + + R LL V F R+A + + + L++ D G + SV+
Sbjct: 1994 MNEKW---EARWERLRMLL----EVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEK 2046
Query: 1221 LQRRHEGFERDLVPLGDKVTIL---------------------------GETAERLSESH 1253
L +RHE FE+ ++ L GETA SH
Sbjct: 2047 LIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAGEAPVSH 2106
Query: 1254 PDATEDLQRQKM--ELNEAWEDLQ 1275
ATE + L+ +WE LQ
Sbjct: 2107 HAATERTSPVSLWSRLSSSWESLQ 2130
Score = 227 bits (578), Expect = 1e-58
Identities = 262/1268 (20%), Positives = 522/1268 (41%), Gaps = 83/1268 (6%)
Query: 994 REVTMKKGDVLTLLSSINKDWWKVEAAD--HQGIVP--AVYVRRLA--HDEFPMLPQRRR 1047
RE + + L + D VEAA H+ I A Y R+ D L +
Sbjct: 434 RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493
Query: 1048 EEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAE--- 1104
+ IT R++ I + L + + RR+RL L + ++W+ E KA
Sbjct: 494 HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLS 553
Query: 1105 -NTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE--- 1160
G L +V +L +K + D+ +++ I P Q+ Q+
Sbjct: 554 AEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRIS 613
Query: 1161 -LNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQ 1219
L + L +A ++ L + + F E D+ + I++K Q S+ D G DL SV
Sbjct: 614 HLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVL 673
Query: 1220 ALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTK 1279
LQR+H+ FE +L L + + + A + ++ + E++ W+ L+
Sbjct: 674 ILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAA 733
Query: 1280 DRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADME 1339
K++L +A+ F+ F A DL+ W+ ++S +++ +D L ++H++ ++E
Sbjct: 734 FCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793
Query: 1340 AEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQM 1399
+ LE A+ SP++ +LQA++ + + R++ L + L+L
Sbjct: 794 ESRGVMEHLEQ-QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYT 852
Query: 1400 FQGNCDQVESWMVARENSL-RSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAE 1458
G D E WM +E L + +L+ LE + + D LD+ + +I + A
Sbjct: 853 VFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAAN 912
Query: 1459 SLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISE 1518
SL+ H E+ + RW+A + + + R + + + D EE +WI++
Sbjct: 913 SLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITD 972
Query: 1519 MLPTACDESYKDATN-------IQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSAC 1571
T ES KD IQRK +V +V + L++ +
Sbjct: 973 --KTKVVESTKDLGRDLAGIIAIQRKL---SGLERDVAAIQARVDALERESQQLMD--SH 1025
Query: 1572 DGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLA 1631
+E + ++ + L+E W L + + L E S+ Q F + DF+ WLS + +A
Sbjct: 1026 PEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVA 1085
Query: 1632 MKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIV-KKKDN 1690
+D L A LL++H ++ E+ +D+ + + E ++ T ++ ++ +
Sbjct: 1086 SEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEG 1145
Query: 1691 VNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQN 1750
++ + + + + L + +F +D E+ + + ++ + L+ +
Sbjct: 1146 LDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEA 1205
Query: 1751 LLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKA 1810
++K + G + + + + +D KL + + ++I+ ++ + K E A+
Sbjct: 1206 GIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQE 1265
Query: 1811 RGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAV 1870
+ L ++LE F+QN +E WIN+K L + D + +KH+A + A
Sbjct: 1266 ASVLLRDNLELQNFLQNCQELTLWINDK-LLTSQDVSYDEARNLHNKWLKHQAFVAELAS 1324
Query: 1871 HETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALN-----------EKTPSLAKAIAA 1919
HE ++N+ A+G+ ++++ Q + +S K+EAL+ EKT L+ A ++
Sbjct: 1325 HEGWLENIDAEGKQLMDEKPQFTAL---VSQKLEALHRLWDELQATTKEKTQHLSAARSS 1381
Query: 1920 -WKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQ 1978
+LQ D + WI+ E L+++ G DL +LAK ++ +
Sbjct: 1382 DLRLQTHAD------------LNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQV- 1428
Query: 1979 SFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPL 2038
+ ++E L E+ + + +IE KR+ LLE +++L + L
Sbjct: 1429 NVRKEELGELFAQVPSMGEEGGDADLSIE-------KRFLDLLEPLGRRKKQLESSRAKL 1481
Query: 2039 QKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQAD 2098
Q + DL E W E+ + +L ++ K ++ +
Sbjct: 1482 QISRDLEDE--------TLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPR 1533
Query: 2099 FKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEM 2158
+ +L+ QQ+ + L+ +W L + R Q L ++
Sbjct: 1534 VEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRL--------RDANE 1585
Query: 2159 CQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218
Q++ +A WI E Y + + K+ L+ + R+Q+ ++ R + ++
Sbjct: 1586 AQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLAS 1645
Query: 2219 LGDNLEDA 2226
L A
Sbjct: 1646 RAQGLLSA 1653
Score = 208 bits (530), Expect = 5e-53
Identities = 197/977 (20%), Positives = 422/977 (43%), Gaps = 56/977 (5%)
Query: 10 VESSGPKVLETAEE-----IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64
V+ SG KV++ + + +R + + T + + R L Q F++DA
Sbjct: 1120 VKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAK- 1178
Query: 65 LGKWIMEKVNILTDKSY-----EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERF 119
+ IL+++ Y E P +++ + EA ++ + +E R++
Sbjct: 1179 ------QAEAILSNQEYTLAHLEPPDSLE-------AAEAGIRKFEDFLGSMENNRDKVL 1225
Query: 120 T---MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRA-------LKFQQYVQECAD 169
+ G+ E + ++++ L+ + + ++ A L+ Q ++Q C +
Sbjct: 1226 SPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQE 1285
Query: 170 ILEWIGDKEAIATSVELGEDWERTEVLHKKF---EDFQVELVAKEGRVVEVNQYANECAE 226
+ WI DK + TS ++ D R LH K+ + F EL + EG + ++ + +
Sbjct: 1286 LTLWINDK--LLTSQDVSYDEARN--LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMD 1341
Query: 227 ENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPV 286
E L+ K ++ W+ L+ ++ + LS A + + + +WI E
Sbjct: 1342 EKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQ 1401
Query: 287 LTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKE 346
L S+D GKDL + + K +E + V +++ EL A+ + I++
Sbjct: 1402 LRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFL 1461
Query: 347 DLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGE 406
DL+ + S KLQ S D ++ + W+ E+ + + T++ +
Sbjct: 1462 DLLEPLGRRKKQLESSRAKLQ-------ISRDLEDETLWVEERLPLAQSADYGTNLQTVQ 1514
Query: 407 VLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWD 466
+ + ++Q ++EI + R + + GQ LV A ++ E++ L ++W L E
Sbjct: 1515 LFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAA 1574
Query: 467 ERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFT 526
R ++ + +Y D+++ ++W+ QE ++ ++++ A +L++H + A
Sbjct: 1575 GRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVE 1634
Query: 527 AQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQK 586
I + A L+ H + E I ++ + L++ A R+R L+ L +
Sbjct: 1635 DYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQ 1694
Query: 587 LYEDSDDLKNWINKKKKLADDEDY-KDIQNLKSRVQKQQVFEKEL-AVNKTQLENIQKTG 644
L ++DDL+ WI++K+ +A + +D ++ K + F +E A+ + +++N+
Sbjct: 1695 LKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI 1754
Query: 645 QEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ--FENNAEDLQRW 702
+ +I+ GH + + + +W +LLE + QL A+ L F AE L
Sbjct: 1755 ERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTR-MQLLAASYDLHRYFYTGAEILG-- 1811
Query: 703 LEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSK 762
L D + + ED G + ++ R H E + QV D+A + +
Sbjct: 1812 LIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKA 1871
Query: 763 D-IRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYL 821
+ I+ +++ + ++AL + A R+ +L+D D +W++ +
Sbjct: 1872 EAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQER 1931
Query: 822 GKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNM 881
+D+ + + L+ H+ I I + E G +++ H A+E++ +++ +
Sbjct: 1932 PRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRR 1991
Query: 882 ESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKH 941
+ + + R L ++ Q+ D AE W+ +EP + + ++G ++ L+K+H
Sbjct: 1992 KEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRH 2051
Query: 942 EAFLLDLNSFGDSMKAL 958
EAF S+ + AL
Sbjct: 2052 EAFEKSTASWAERFAAL 2068
Score = 171 bits (433), Expect = 8e-42
Identities = 202/962 (20%), Positives = 402/962 (41%), Gaps = 74/962 (7%)
Query: 1298 ARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAEL-- 1355
A DL WI +++S++ A LTG++ L+ +R + P FQ + L
Sbjct: 311 ASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT--VEKPPKFQEKGNLEVLLFT 368
Query: 1356 IDSGHHASPEIEKKLQAVKLERDDLEKAWE-------------KRKKILDQCLE--LQMF 1400
I S A+ + KL D+ +AWE + + I + LE + F
Sbjct: 369 IQSRMRANNQKVYTPHDGKLV-SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRF 427
Query: 1401 QGNCDQVESWMVARENSLRSDDKS-SLDSLEALMKKRDDLDKAITAQEGKITDLEHFAES 1459
E+W+ + + D+ L ++EA KK + ++ A E ++ LE A+
Sbjct: 428 DRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQE 487
Query: 1460 LIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEM 1519
L + ++ ++ I R +L W L+ L R +L L++ ++D+ +W+ E+
Sbjct: 488 LEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEI 547
Query: 1520 LPTACDESY-KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIE---CSACDGNE 1575
+ K ++ KH+ ++ + ++V + E CD
Sbjct: 548 KAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCD--P 605
Query: 1576 EAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQ 1635
+ +++++ L++ ++ L + +L ++ R +F + + E W+ E E + + D
Sbjct: 606 QVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDY 665
Query: 1636 ARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRF 1695
+DL S L +KH+ E E+ + L+ + A +++ F QI + V+ ++
Sbjct: 666 GKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQW 725
Query: 1696 LNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKH 1755
+++LAA + L++A FQF D DD ++W+++ +S +D G+D + L KKH
Sbjct: 726 DQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKH 785
Query: 1756 KRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKL 1815
K EL ++++ A+ ++ ++ RL E ++++ A R +L
Sbjct: 786 KDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVVAQADLRQQRL 844
Query: 1816 EESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRV 1875
+E+L+ + E W+ EK + DTL + + + + L+ + T++
Sbjct: 845 QEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQI 904
Query: 1876 QNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNW 1935
V + V +++E+ + LN + + ++ + + D A + N+
Sbjct: 905 DGVNLAANSL---VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV--DSALRVHNY 959
Query: 1936 KADVVEA--WIADKETSLK-TNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLK 1992
D E WI DK ++ T G DL + + K L+ + + Q R+ +
Sbjct: 960 CVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAI-QARVDALERES 1018
Query: 1993 DKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKA 2052
+L+ + Q + I +R L + W+ L Q LQ EDL E +
Sbjct: 1019 QQLMDSHPEQKEDIGQRQKHLEELWQGL--------------QQSLQGQEDLLGEVSQLQ 1064
Query: 2053 SALNN------WCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELD 2106
+ L + W ++ ++ SL E QL + H + Q ++ + E
Sbjct: 1065 AFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESG 1124
Query: 2107 QQIKALGVPSSPYTWL--TVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQ 2164
+++ G Y L +E L+ W L + E R L Q F QEF++
Sbjct: 1125 EKV-IQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTL-----AQCLGF---QEFQK 1175
Query: 2165 NASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKI---VDLGD 2221
+A + IL + Y L + L+ +LE+ ++ + + +M+ K+ VD G+
Sbjct: 1176 DAKQ-AEAILSNQEYTL--AHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGN 1232
Query: 2222 NL 2223
L
Sbjct: 1233 KL 1234
Score = 164 bits (414), Expect = 1e-39
Identities = 204/1037 (19%), Positives = 417/1037 (40%), Gaps = 84/1037 (8%)
Query: 1365 EIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVAR--ENSLRSDD 1422
E EK ++ DL E+ +L+ G Q++++ R E + +
Sbjct: 299 ETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQE 358
Query: 1423 KSSLDSLEALMKKR--DDLDKAITAQEGK-ITDLEHFAESLIADEHYAKEEIATRLQRVL 1479
K +L+ L ++ R + K T +GK ++D+ ESL E+ + E+A R + +
Sbjct: 359 KGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEY--RRELALRNELI- 415
Query: 1480 DRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYK-DATNIQRKY 1538
+ KL A ++F R E W+SE +++ D ++
Sbjct: 416 ------------RQEKLEQLA--RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAK 461
Query: 1539 LKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTND 1598
KH+ + E+V + +L L + + D ++ + + + + W +L E
Sbjct: 462 KKHEAIETDTAAYEERVRALEDLAQELEKENYHD--QKRITARKDNILRLWSYLQELLQS 519
Query: 1599 KGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLA 1658
+ ++L Q+ + W+ E + L + + L +LL+KH+L+E ++
Sbjct: 520 RRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAI 579
Query: 1659 REDALKDLNTLAEDLLSSGTFNV--DQIVKKK-DNVNKRFLNVQELAAAHHEKLKEAYAL 1715
+ D +K + + Q+++ + ++ + F + +AA +L+++ L
Sbjct: 580 QGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRL 639
Query: 1716 FQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775
++FF ++D+ ESWI+EK SS DYG+DL V L +KHK E EL + ++ +
Sbjct: 640 WKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQE 699
Query: 1776 AEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWI 1835
A + + G +I+ R+ + W++LK+LA L+++ + QF +A++ +AW+
Sbjct: 700 AHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWL 759
Query: 1836 NEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQ 1895
+ + L D G AT++L KH+ DF + V E +E
Sbjct: 760 QDAHRLLSGEDVGQDEGATRALGKKHK----DFLEELEESRGVMEHLEQQAQGFPEEFRD 815
Query: 1896 NKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNG 1955
+ +++ +++AL E + + +L++ + D E W+ +KE L
Sbjct: 816 SPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEME 875
Query: 1956 NGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLK 2015
L D + + D LD +++ + + + + L+ + H +S+ +++ L
Sbjct: 876 MPDTLEDLEVVQHRFDILDQEMKTLMTQ-IDGVNLAANSLVESGHPRSREVKQYQDHLNT 934
Query: 2016 RWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEEN---LSEPVHC 2072
RW+ + R E A ++N+C EE +++
Sbjct: 935 RWQAFQTLVSERR------------------EAVDSALRVHNYCVDCEETSKWITDKTKV 976
Query: 2073 V--------SLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTV 2124
V L I +Q+ +A QA L QQ+ + S P
Sbjct: 977 VESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL----MDSHPE---QK 1029
Query: 2125 EVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGS 2184
E + + KHL ++ + +Q LQ +E + Q F Q+ F W+ T+
Sbjct: 1030 EDIGQRQKHLEELWQGLQQSLQGQE-DLLGEVSQLQAFLQDLDDFQAWLSITQKAVASED 1088
Query: 2185 LLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL----EDALILDIKYSTIGLAQ 2240
+ + E L+ + + EI + ++ + G+ + D L + GL
Sbjct: 1089 MPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDT 1148
Query: 2241 QWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCL 2300
W+ L ++ H L Q + ++ ++ K+ I + + L +
Sbjct: 1149 GWNALGRMWESRSHTLAQCLGFQEF----QKDAKQAEAILSNQEYTLAHLEPPDSLEAAE 1204
Query: 2301 RGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENA 2360
G+ + + E+ +K L VD G K Y+ DK E ++ ++
Sbjct: 1205 AGIRKFEDFLGSMENNR--DKVLSPVDSGNKLVAEGNLYS----DKIKEKVQLIEDRHRK 1258
Query: 2361 FQALAEGKSYITKEDMK 2377
A+ S + +++++
Sbjct: 1259 NNEKAQEASVLLRDNLE 1275
Score = 149 bits (377), Expect = 2e-35
Identities = 191/937 (20%), Positives = 367/937 (39%), Gaps = 66/937 (7%)
Query: 1266 ELNEAWEDLQGRTKDRKESLNEA--------QKFYLFLSKARDLQNWISSIGGMVSSQEL 1317
++N AWE L+ R+ +L Q F KA + W+S +V+
Sbjct: 391 DINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF 450
Query: 1318 AEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLER 1377
DL +E ++H+ D A +ALED + EL +H I + +
Sbjct: 451 GYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLW 510
Query: 1378 DDLEKAWEKRKKILDQCLELQ-MFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKR 1436
L++ + R++ L+ L LQ +FQ ++ + + L ++ L +E L++K
Sbjct: 511 SYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKH 570
Query: 1437 DDLDKAITAQEGKITDLEHFAESLIADEHYA---KEEIATRLQRVLDRWKALKAQLIDER 1493
++ I Q K+ + + Y + I R+ + ++ L +
Sbjct: 571 KLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRK 630
Query: 1494 TKLGDYANLKQFYRDLEELEEWISEMLPTACDESY-KDATNIQRKYLKHQTFAHEVDGRS 1552
+L L +F+ +++E E WI E Y KD T++ KH+ F E+ G
Sbjct: 631 AQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLD 690
Query: 1553 EQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRF 1612
+ + + ++ + ++ +++++ WD L + K L +A +F
Sbjct: 691 AHLEQIFQEAHGMV--ARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
Query: 1613 NTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAED 1672
D + WL +A LL+ +D +D + L KKH+ E+ ++ L A+
Sbjct: 749 QGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG 808
Query: 1673 LLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEK 1732
+ D + + + + + V A ++L+EA L+ F + D E W+ EK
Sbjct: 809 FPEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEK 867
Query: 1733 ---LIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEE 1789
L + D DL+ VQ+ + L+ E+ I V A L + E
Sbjct: 868 EKWLAEMEMPDTLEDLEVVQH---RFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
Query: 1790 IQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEK-NALAVRGDCG 1848
++ W+ + L R ++ +L + + EE WI +K + D G
Sbjct: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
Query: 1849 DTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNE 1908
LA ++ K LE D A + RV + + + +++ Q ++I + + L E
Sbjct: 985 RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD---SHPEQKEDIGQRQKHLEE 1041
Query: 1909 KTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLA 1968
L +++ + L + Q F D +AW++ + ++ + L + LL
Sbjct: 1042 LWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQ 1101
Query: 1969 K----QDTLDASLQSFQQERLPEITDLKDKLISAQHN--------QSKAIEERYAALLKR 2016
+ +D +D S+Q+ + + +K+I Q + + + ++ + AL +
Sbjct: 1102 QHAGIKDEIDGHQDSYQR-----VKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
Query: 2017 WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLN 2076
WE R L + L Q+ F + A +A A+ + E +L P SL
Sbjct: 1157 WES--------RSHTLAQCLGFQE----FQKDAKQAEAILSNQEYTLAHLEPP---DSLE 1201
Query: 2077 EIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSD 2136
+ EDFL S+ + ++ ++ A G S V+++E D
Sbjct: 1202 AAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIE-------D 1254
Query: 2137 IIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173
+ ++ Q+ N E+ Q F QN WI
Sbjct: 1255 RHRKNNEKAQEASVLLRDNLEL-QNFLQNCQELTLWI 1290
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
sapiens]
Length = 2564
Score = 361 bits (927), Expect = 4e-99
Identities = 332/1377 (24%), Positives = 578/1377 (41%), Gaps = 65/1377 (4%)
Query: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY-E 82
+ ER R+Q +E A R ++L+++ L F D D L W+ + + +
Sbjct: 744 LAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGH 803
Query: 83 DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHE-----ETKAHIEELR 137
D + + ++H++L EV+ +S L R + T+G ++ + + E
Sbjct: 804 DEASSRRLARQHRALTGEVEAHRGPVSGL---RRQLATLGGASGAGPLVVALQVRVVEAE 860
Query: 138 HLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLH 197
L+ + E+ + L AL + E WIG+KE S+ + + + EV+
Sbjct: 861 QLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQ 920
Query: 198 KKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQ 257
+FE E+ + GRV++VN E E HP ++S Q+ +N+ W R+ L QR+
Sbjct: 921 HRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRK 980
Query: 258 KALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMS 317
+ +S ++ +V E ++EK + S A L GLE L +
Sbjct: 981 EEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPR-----AGGALQWRLSGLEAALQALE 1035
Query: 318 DKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSS 377
+ L +A L P+ A ++ + E+L + W + + A + E + A RF
Sbjct: 1036 PRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLH 1095
Query: 378 DFDELSGWMNEKTAAINADE--LPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQD 435
D D W+ A E LP + + LL RH K E+D ++ + +
Sbjct: 1096 DLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEA 1155
Query: 436 LVNANHE------ASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVD 489
L+ A+ A DE +E+ W LL LW+ R Q + LF RD Q
Sbjct: 1156 LLAADGAELGPGLALDEWLPHLEL---GWHKLLGLWEARREALVQAHIYQLFLRDLRQAL 1212
Query: 490 SWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYD 549
+ QE L +L ++ S E L++H DF ++K+ + A L+ +
Sbjct: 1213 VVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIY 1272
Query: 550 SENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDED 609
E + LL + + +A + L + L LQ D +L WI++K +A D
Sbjct: 1273 GEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGT 1332
Query: 610 YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLW 669
+D L R + Q F ELA NK LE I++ GQ++++ + +V +L E+ W
Sbjct: 1333 REDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCW 1392
Query: 670 EELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729
EL T+ K QL EA++ Q + +L + L +E Q+ D G LA V ++L+K
Sbjct: 1393 AELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKL 1452
Query: 730 GLLESAVAARQDQVDILTDLAAYFEEIGHPDSKD-IRARQESLVCRFEALKEPLATRKKK 788
+ES V +V L A P SK+ + RQ ++ R L EPL R++
Sbjct: 1453 QSMESQVEEWYREVGELQAQTAALPL--EPASKELVGERQNAVGERLVRLLEPLQERRRL 1510
Query: 789 LLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPR 848
LL L + D +DE AW+QE P A T G L A ++ + +++ + I +H PR
Sbjct: 1511 LLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPR 1570
Query: 849 IQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADL 908
++E+ ER + AE V ++ L LR A RRQ L+A Q +QY D+
Sbjct: 1571 LEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDV 1630
Query: 909 HEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQ 968
E E W+ E+E ++ + + G DE++ LLKKH + ++ +S+ L Q A +
Sbjct: 1631 AEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEM 1690
Query: 969 QAAPVEGVA----------------GEQRVMA------LYDFQAR-SPREVTMKKGDVLT 1005
E ++ GE+R +A LY + S E + + +V+
Sbjct: 1691 GHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA 1750
Query: 1006 LLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRRE-------EPGNITQRQE 1058
+ +D+ V + A + + Q E + + ++
Sbjct: 1751 GSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD 1810
Query: 1059 QIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAE----NTGVE-LDDV 1113
+ + LL+ R + L +A ++ I+EK+ T E
Sbjct: 1811 GLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSA 1870
Query: 1114 WELQKKFDEFQKDLNTNEPRLRDINKVADDL--LFEGLLTPEGAQIRQELNSRWGSLQRL 1171
+Q+ F+ DL ++R + + A L ++ G A QE+ W L
Sbjct: 1871 SSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSA 1930
Query: 1172 ADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERD 1231
++ R + S FH + D ++ + AAD D+ SV+ L H+G + +
Sbjct: 1931 CEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTE 1990
Query: 1232 LVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKF 1291
L ++T E L + +++Q Q +L E++ + E L + +
Sbjct: 1991 LEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEV 2050
Query: 1292 YLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQAL 1348
+ F +A W+++ ++ S+EL + +E L+ RH+ R A F +L
Sbjct: 2051 HQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSL 2107
Score = 332 bits (852), Expect = 2e-90
Identities = 387/1741 (22%), Positives = 721/1741 (41%), Gaps = 151/1741 (8%)
Query: 664 EVASLWEELLEATKQKGTQLHEA---NQQLQ-----FENNAEDLQRWLEDVEWQVTSEDY 715
++ W EL +A ++ L ++L+ F++ + WL + + V+ +++
Sbjct: 398 DIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNF 457
Query: 716 GKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRF 775
G L V+ ++KH +E+ +AA +++V + +LA G+ D + + A+++S++ ++
Sbjct: 458 GYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQW 517
Query: 776 EALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRH 835
L + R+ +L L LQ + ++ W++E + S G+ L+ + LL +H
Sbjct: 518 ALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKH 577
Query: 836 RVILENIASHEPRIQEITERGNKMVEEGHFAAED---VASRVKSLNQNMESLRARAARRQ 892
++ +IA+ R++ + + + + D + +RV ++ + L+ +AARR+
Sbjct: 578 GLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRR 637
Query: 893 NDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGA---------------L 937
+LEA+ L +L EAE+W R+KE +++ G AAGA L
Sbjct: 638 AELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARL 697
Query: 938 LKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGV-----------------AGEQ 980
L +H+ +L +AL QA C ++ A V + +
Sbjct: 698 LAQHKILQGELGG----RRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARR 753
Query: 981 RVMALYDFQARSPREVTMKK-----GDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLA 1035
R L + AR R + + G L L +D +++ AA G A RRLA
Sbjct: 754 RWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASS-RRLA 812
Query: 1036 HDEFPMLPQ-RRREEPGNITQRQ---------------------EQIENQYRSLLDRAEE 1073
+ + P + +RQ + E + + + A
Sbjct: 813 RQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAAL 872
Query: 1074 RRRRLLQRYNEFLLAYEAGDMLEWIQEKK----AENTGVELDDVWELQKKFDEFQKDLNT 1129
RR+ L + + E WI EK+ + LDDV +Q +F+ +++N+
Sbjct: 873 RRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNS 932
Query: 1130 NEPRLRDINKVADDLLFEGLLTPEGAQIRQ---ELNSRWGSLQRLADEQRQLLGSAHAVE 1186
R+ D+N +L+ G P ++R LNSRW + L +++++ + + VE
Sbjct: 933 LMGRVLDVNHTVQELVEGG--HPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVE 990
Query: 1187 VFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETA 1246
E + + Q+ +K +A+ +A ALQ R G E L L + L E A
Sbjct: 991 NHVLEVAEVRAQVREKRRAVESAPRAGG-----ALQWRLSGLEAALQALEPRQAALLEEA 1045
Query: 1247 ERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWI- 1305
L+E P L + EL W L + E++ A + FL +W+
Sbjct: 1046 ALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLV 1105
Query: 1306 ---SSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDS-GHH 1361
+ GG S L L + LL RH + +++ + + S L+ + G
Sbjct: 1106 RAQEAAGG--SEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAE 1163
Query: 1362 ASP--EIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLR 1419
P +++ L ++L L WE R++ L Q Q+F + Q + +E +L
Sbjct: 1164 LGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALS 1223
Query: 1420 SDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRV 1478
+ +++S+E +K+ D + + K+ AE L+ + E+ + R+
Sbjct: 1224 GAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRL 1283
Query: 1479 LDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKY 1538
L++ + + + KL D L+ F RD EL+ WI E + A D + +D + +++
Sbjct: 1284 LEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRW 1343
Query: 1539 LKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTND 1598
L+HQ F E+ E + + G L++ +++++L ++++ W L T
Sbjct: 1344 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKP--ELAASVRKKLGEIRQCWAELESTTQA 1401
Query: 1599 KGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLA 1658
K ++L EAS+ + S + + L E+ L D DLA+ + LKK Q +E ++
Sbjct: 1402 KARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQV-- 1459
Query: 1659 REDALKDLNTLAEDL--LSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF 1716
E+ +++ L L + + + ++++ V +R + + E L + L
Sbjct: 1460 -EEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELH 1518
Query: 1717 QFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMA 1776
Q DLDDE +W++E+L + G LQ VQ +KK++ L E+ AH P ++ VL+ A
Sbjct: 1519 QVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERA 1578
Query: 1777 EKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWIN 1836
L + E ++ L Q W L+E A+ R L+ + + Q+ + E EAW+
Sbjct: 1579 GALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLG 1638
Query: 1837 EKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQN 1896
E+ L + D G +T LL KH LE +E + + Q +L + Q
Sbjct: 1639 EQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQI 1698
Query: 1897 KEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGN 1956
S+++ L L + ++ LE Y + + + +E WIA+KE +
Sbjct: 1699 SRRQSQVDRLYVALKELGE---ERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPEL 1755
Query: 1957 GADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKR 2016
G D L K + +ERL + + D+LI H + + E L +
Sbjct: 1756 GQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEA 1815
Query: 2017 WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENL------SEPV 2070
W +LLE R +LL L K F A L E+ L EP
Sbjct: 1816 WAELLELMGT-RAQLLAASRELHK-------FFSDARELQGQIEEKRRRLPRLTTPPEPR 1867
Query: 2071 HCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKAL--GVPSSPYTWLTVEVLE 2128
S +Q+ F L + + L E Q++ + G + EVL+
Sbjct: 1868 PSAS-----SMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ 1922
Query: 2129 RTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKE 2188
WK L E+ V + F L W+ + ++
Sbjct: 1923 -GWKELLSACEDAR--------LHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRD 1973
Query: 2189 TGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL---EDALILDI--KYSTIG-----L 2238
++E + ++ + E++A +LT +LG +L + A+ +I + +G +
Sbjct: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEV 2033
Query: 2239 AQQWDQLYQLGLRM--QHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEF 2296
+++WD+ ++ +M H Q+ D ++E L + + DE H+ F
Sbjct: 2034 SEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF 2093
Query: 2297 R 2297
R
Sbjct: 2094 R 2094
Score = 270 bits (690), Expect = 1e-71
Identities = 348/1706 (20%), Positives = 686/1706 (40%), Gaps = 112/1706 (6%)
Query: 489 DSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHY 548
+SW++ + + ++ G L + EA ++KHE E A EE++ V + A L + +Y
Sbjct: 442 ESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYY 501
Query: 549 DSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKK-KLADD 607
D + A RD +L + L RR L+++L LQK++++ + +W+ + + +L
Sbjct: 502 DIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSR 561
Query: 608 EDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIE-GGHYASDN--VTTRLSE 664
E + + +QK + E ++A ++E + + G+ D + R++
Sbjct: 562 ECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNH 621
Query: 665 VASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKG------ 718
V EL E ++ +L + E+ + W D E + + G
Sbjct: 622 VHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGA 681
Query: 719 ---------LAEVQNRLRKHGLLESAVAAR----QDQVDILTDLAAYFEEIGHPDSKDIR 765
L+ L +H +L+ + R Q + +L A +G P + +
Sbjct: 682 AGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVG-PGADTVH 740
Query: 766 A-----RQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY 820
R S R++ L+E A R+++L + L D + W+++ A +
Sbjct: 741 LVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGD 800
Query: 821 LGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQN 880
G D +S++L +HR + + +H + + + + VA +V+ +
Sbjct: 801 FGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAE 860
Query: 881 M---ESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGAL 937
E A RRQ +A ++ + ++H E WI EKE + + + +
Sbjct: 861 QLFAEVTEVAALRRQWLRDALAVYRMF-GEVHACELWIGEKEQWLLSMRVPDSLDDVEVV 919
Query: 938 LKKHEAFLLDLNSF---------------------GDSMKALRNQANACQQQQAAPVEGV 976
+ E+ ++NS D +++ ++ N+ + VE
Sbjct: 920 QHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQR 979
Query: 977 AGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDW----WKVEAADHQGIVPAVYVR 1032
E + L + EV + + + S + W++ + + A+ R
Sbjct: 980 KEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLE--AALQALEPR 1037
Query: 1033 RLAH-DEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQ--RYNEFLLAY 1089
+ A +E +L +R + + Q E++ ++ +L A+ + R FL
Sbjct: 1038 QAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDL 1097
Query: 1090 EAGDMLEWIQEKKAENTGVE------LDDVWELQKKFDEFQKDLNTNEPRLRDINKVADD 1143
+A L+W+ + G E L++ L + +++++ E I +
Sbjct: 1098 DA--FLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAAS-- 1153
Query: 1144 LLFEGLLTPEGAQIRQ---------ELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADD 1194
E LL +GA++ L W L L + +R+ L AH ++F R+
Sbjct: 1154 ---EALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQ 1210
Query: 1195 TKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHP 1254
+ + ALS A+ + SV+ ++H F + K+ + + AE L
Sbjct: 1211 ALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGN 1270
Query: 1255 DATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSS 1314
E Q L E ++ Q R + + L++ + FL +L WI +++
Sbjct: 1271 IYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHE-KMLMAR 1329
Query: 1315 QELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVK 1374
ED + RHQ A++ + +E +L+ + + KKL ++
Sbjct: 1330 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIR 1389
Query: 1375 LERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRS-DDKSSLDSLEALM 1433
+LE + + + L + + + +++ ++ E+ L+ D L ++ + +
Sbjct: 1390 QCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL 1449
Query: 1434 KKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDER 1493
KK ++ + ++ +L+ +L E +KE + R V +R L L + R
Sbjct: 1450 KKLQSMESQVEEWYREVGELQAQTAALPL-EPASKELVGERQNAVGERLVRLLEPLQERR 1508
Query: 1494 TKLGDYANLKQFYRDLEELEEWISEMLPTACD-ESYKDATNIQRKYLKHQTFAHEVDGRS 1552
L L Q DL++ W+ E LP A E +Q+ K+Q E+
Sbjct: 1509 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHG 1568
Query: 1553 EQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRF 1612
++ V+ +L + + EA++ LEQL+ W L E + + L+ A + +++
Sbjct: 1569 PRLEEVLERAGALASLRSPEA--EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQY 1626
Query: 1613 NTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAED 1672
+ + E WL E E L+ +D+ +D S LLKKH LE+ + E+++ L+
Sbjct: 1627 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRA 1686
Query: 1673 LLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEK 1732
LL G + +QI +++ V++ ++ ++EL L++ Y L+Q + + + E WI EK
Sbjct: 1687 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 1746
Query: 1733 LIRVSSQDYGRDLQGVQNLLKKHKRLEGEL-VAHEPAIQNVLDMAEKLKDKAAVGQEEIQ 1791
+ S + G+D + V L +K E +A + V M ++L + +
Sbjct: 1747 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 1806
Query: 1792 LRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCG-DT 1850
E W +L EL R L S E +F +A E + I EK R +
Sbjct: 1807 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEP 1866
Query: 1851 LAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKT 1910
+ S+ A E+D + ++V+ + +G L V E + I+S+ + + +
Sbjct: 1867 RPSASSMQRTLRAFEHDLQLLVSQVRQL-QEGAAQLRTVYAGEHA-EAIASREQEVLQGW 1924
Query: 1911 PSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQ 1970
L A +L + F+ + + +W+ + + D+ L+
Sbjct: 1925 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYH 1984
Query: 1971 DTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLK---RWEQLLEASAVH 2027
L L++ R+PE+T ++ S N+S +E A L K R E++ E H
Sbjct: 1985 QGLKTELEA----RVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRH 2040
Query: 2028 RQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHED 2087
+ L++ L + +FA +A + W E L S++E+ QL + HE
Sbjct: 2041 WE-WLQQMLEVH-------QFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEA 2092
Query: 2088 FLASLARAQADFKCLLELD--QQIKA 2111
F + A + F L L ++IKA
Sbjct: 2093 FRKAAAAWEERFSSLRRLTTIEKIKA 2118
Score = 267 bits (682), Expect = 1e-70
Identities = 373/1843 (20%), Positives = 728/1843 (39%), Gaps = 137/1843 (7%)
Query: 47 QKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEA------- 99
Q LE ++ ++ A +L WI V +++++ + + ++ G Q+ Q+ A
Sbjct: 303 QVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFAN--SLSGVQQQLQAFTAYCTLEKP 360
Query: 100 -EVQTKSRL-------MSELEKTREERFTMGHSAH----EETKAHIEELRHLWDLLLELT 147
+ Q K L S+L F ++ +E+ H + L
Sbjct: 361 VKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAE 420
Query: 148 LEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVEL 207
L + ++L L Q++ + A W+ + + + + G + E KK E + ++
Sbjct: 421 LIRQEKL--ELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADI 478
Query: 208 VAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQ 267
A E RV V + A A E + D+ + ++++ V W L GL R+ L LQ
Sbjct: 479 AAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQ 538
Query: 268 RFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKA 327
+ +++ + W++E + L S + G+ LV ++ L H LE ++A S++V+ L A A
Sbjct: 539 KVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAA 598
Query: 328 ---EKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSG 384
+L P D I + ++ A R +L+A+ + +E
Sbjct: 599 LRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAES 658
Query: 385 WMNEKT----------AAINADELPT-----DVAGGEVLLDRHQQHKHEIDSYDDRFQSA 429
W +K AA A T D++ LL +H+ + E+ Q A
Sbjct: 659 WARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQA 718
Query: 430 DETGQDLVNAN---HEASDEVR-----EKMEILDNNWTALLELWDERHRQYEQCLDFHLF 481
G++LV A +D V E+ W L E R R+ ++ H F
Sbjct: 719 LRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQF 778
Query: 482 YRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATK 541
D + + W+ D G+ S+ L ++H A + + +
Sbjct: 779 GADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLAT 838
Query: 542 LIGDDHYDSENIKAIRDGLLARRD---ALREKAATRRRLLKESLLLQKLYEDSDDLKNWI 598
L G + A++ ++ + E AA RR+ L+++L + +++ + + WI
Sbjct: 839 L-GGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWI 897
Query: 599 NKKKK----LADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYA 654
+K++ + + D++ ++ R + ++E+ ++ ++ T QE++EGGH +
Sbjct: 898 GEKEQWLLSMRVPDSLDDVEVVQHRFES---LDQEMNSLMGRVLDVNHTVQELVEGGHPS 954
Query: 655 SDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDV-EWQVTSE 713
SD V + + S W ++E +Q+ E + L EN+ ++ V E + E
Sbjct: 955 SDEVRSCQDHLNSRWNRIVELVEQR---KEEMSAVLLVENHVLEVAEVRAQVREKRRAVE 1011
Query: 714 DYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVC 773
+ +Q RL LE+A+ A + + L + AA E + + E L
Sbjct: 1012 SAPRAGGALQWRLSG---LEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGA 1068
Query: 774 RFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY--LGKDLIASKKL 831
+ AL + + LQ D + W+ + +A + L L + L
Sbjct: 1069 EWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADAL 1128
Query: 832 LNRHRVILENIASHEPRIQEITERGNKMV-----EEGHFAAEDVASRVKSLNQNMESLRA 886
L RH + E + E I ++ E G A D L + + L
Sbjct: 1129 LARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWH-KLLGL 1187
Query: 887 RAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLL 946
ARR+ ++A++ +Q +L DL +A +R +E + E+ LK+H FL
Sbjct: 1188 WEARREALVQAHI-YQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLT 1246
Query: 947 DLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARS---PREVTMKKGDV 1003
+ M+ A +Q + G ++ V L + + ++ K D
Sbjct: 1247 TMELSQQKMQVAVQAAEGLLRQ--GNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQ 1304
Query: 1004 LTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQ---EQI 1060
L L + +D +++ H+ ++ A R + + R + + Q + E+I
Sbjct: 1305 LELQHFL-RDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKI 1363
Query: 1061 ENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKF 1120
E + + L+ E + ++ E + LE + KA E +L + F
Sbjct: 1364 EREGQQLMQEKPELAASVRKKLGEIRQCWAE---LESTTQAKARQL-FEASKADQLVQSF 1419
Query: 1121 DEFQKDLNTNEPRLRDINKVADDLLFEGL-----------------------------LT 1151
E K L E +L+D++ D L
Sbjct: 1420 AELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLE 1479
Query: 1152 PEGAQIRQELNSRWGS-----LQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQAL 1206
P ++ E + G L+ L + +R LL S +V H + DD ++++
Sbjct: 1480 PASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAH-DLDDELAWVQERLPLA 1538
Query: 1207 SAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKME 1266
+ G+ L +VQ ++++G R++ G ++ + E A L+ E ++R +
Sbjct: 1539 MQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQ 1598
Query: 1267 LNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEI 1326
L AW L+ + R++ L+ A + + +++ W+ ++ S++ +D
Sbjct: 1599 LQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ 1658
Query: 1327 LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEK 1386
LL++H + +E + L L++ GH S +I ++ V L++ E+
Sbjct: 1659 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE 1718
Query: 1387 RKKILDQCLELQMFQGNCDQVESWMVARENSLRSDD-KSSLDSLEALMKKRDDL-DKAIT 1444
R+ L+Q L ++E W+ +E S + + + L +K + +
Sbjct: 1719 RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGM 1778
Query: 1445 AQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQ 1504
A ++ + + LI H A +A + + W L + L L +
Sbjct: 1779 AGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHK 1838
Query: 1505 FYRDLEELEEWISE---MLP--TACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVI 1559
F+ D EL+ I E LP T E A+++QR + F H++ QV +
Sbjct: 1839 FFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL---RAFEHDLQLLVSQVR-QL 1894
Query: 1560 NLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDF 1619
G + + + EA+ + +++ + W LL D ++ + RF++ +RD
Sbjct: 1895 QEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDL 1954
Query: 1620 EFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTF 1679
W+ + + D+ RD++S L+ HQ L+ E+ AR L L LL + +
Sbjct: 1955 LSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSA 2014
Query: 1680 NVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQ 1739
D+I + D + R V E H E L++ + QF Q+ ++W+ + + S+
Sbjct: 2015 MADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSR 2074
Query: 1740 DYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNV--LDMAEKLK 1780
+ G + V+ L+++H+ A E ++ L EK+K
Sbjct: 2075 ELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIK 2117
Score = 244 bits (623), Expect = 7e-64
Identities = 190/837 (22%), Positives = 367/837 (43%), Gaps = 9/837 (1%)
Query: 22 EEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY 81
E+ QE +L + Q + R + QKL D LQ F RD +L WI EK+ + D +
Sbjct: 1274 EQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR 1333
Query: 82 EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWD 141
ED + ++ +HQ+ AE+ + ++E+ ++ + + E+R W
Sbjct: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 1393
Query: 142 LLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFE 201
L T K QL A K Q VQ A++ + + E+ V+ G D KK +
Sbjct: 1394 ELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQ 1453
Query: 202 DFQVELVAKEGRVVEVNQYANECAEENHP-DLPLIQSKQNEVNAAWERLRGLALQRQKAL 260
+ ++ V E+ A A P L+ +QN V RL +R++ L
Sbjct: 1454 SMESQVEEWYREVGELQ--AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLL 1511
Query: 261 SNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKV 320
+ L + D+ + + W++E+ P+ + G L A + ++GL R + ++
Sbjct: 1512 LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 1571
Query: 321 KELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFD 380
+E+ +A L +A ++ E L S+W +R A R + L A + ++ D
Sbjct: 1572 EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVA 1631
Query: 381 ELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNAN 440
E+ W+ E+ + +++ D LL +H Q + +++Y++ + L+
Sbjct: 1632 EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMG 1691
Query: 441 HEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLE 500
H S+++ + +D + AL EL +ER EQ + R +++ W++ +E
Sbjct: 1692 HPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAG 1751
Query: 501 NEDLGNSLGSAEALLQKHEDF-EEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDG 559
+ +LG L +K +F E A E++ V++ +LI H + + +DG
Sbjct: 1752 SPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG 1811
Query: 560 LLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWI-NKKKKLADDEDYKDIQNLKS 618
L L E TR +LL S L K + D+ +L+ I K+++L + + S
Sbjct: 1812 LNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSAS 1871
Query: 619 RVQKQ-QVFEKELAVNKTQLENIQKTGQEM--IEGGHYASDNVTTRLSEVASLWEELLEA 675
+Q+ + FE +L + +Q+ +Q+ ++ + G +A + + +R EV W+ELL A
Sbjct: 1872 SMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA-EAIASREQEVLQGWKELLSA 1930
Query: 676 TKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESA 735
+ + L+F + DL W++ + Q+ + D + ++ V+ + H L++
Sbjct: 1931 CEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTE 1990
Query: 736 VAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHL 795
+ AR ++ +L + +I+A+ + L R E + E + L +L +
Sbjct: 1991 LEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEV 2050
Query: 796 QLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEI 852
++ +AW+ EP S LG + ++L+ RH + A+ E R +
Sbjct: 2051 HQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSL 2107
Score = 194 bits (492), Expect = 1e-48
Identities = 247/1268 (19%), Positives = 493/1268 (38%), Gaps = 67/1268 (5%)
Query: 13 SGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEK 72
+GP V+ + E Q + E A R Q L D+ + + WI EK
Sbjct: 845 AGPLVVALQVRVVEAEQ----LFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEK 900
Query: 73 VNILTDKSYEDPTN-IQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKA 131
L D + ++ + +SL+ E+ + + ++ T +E GH + +E ++
Sbjct: 901 EQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRS 960
Query: 132 HIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKE-AIATSVELGEDW 190
+ L W+ ++EL ++ +++ L + +V E A++ + +K A+ ++ G
Sbjct: 961 CQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG-- 1018
Query: 191 ERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLR 250
L + + L A E R + + A AE + E+ A W L
Sbjct: 1019 ----ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALA 1074
Query: 251 GLALQRQKALSNAANLQRFKRDVTEAIQW-IKEKEPVLTSED-YGKDLVASEGLFHSHKG 308
A +A++ A LQRF D+ + W ++ +E SE L ++ L H
Sbjct: 1075 SAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAA 1134
Query: 309 LERNLAVMSDKVKELCAKAEKLTLSHPSDAPQ---IQEMKEDLVSSWEHIRALATSRYEK 365
L+ + + + A +E L + ++ + E L W + L +R E
Sbjct: 1135 LKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREA 1194
Query: 366 LQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDR 425
L + Y F D + + + A++ ELP V E L +H+ ++ +
Sbjct: 1195 LVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQK 1254
Query: 426 FQSADETGQDLVNANHEASDEVREKM-EILDNNWTALLELWDERHRQYEQCLDFHLFYRD 484
Q A + + L+ + ++ +E + +L+ N L + ++Q L+ F RD
Sbjct: 1255 MQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQ-LELQHFLRD 1313
Query: 485 SEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIG 544
++D W+ ++ + + +H+ F +E + +++ +L+
Sbjct: 1314 CHELDGWI-HEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQ 1372
Query: 545 DDHYDSENIKAIRDGLLARRDALREKAAT---RRRLLKESLLLQKLYEDSDDL-KNWINK 600
+ E ++R L R E +T + R L E+ +L + +L K ++
Sbjct: 1373 EK---PELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHM 1429
Query: 601 KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQ-KTGQEMIEGGHYASDNVT 659
+ +L D + D+ + S+++K Q E ++ ++ +Q +T +E + + V
Sbjct: 1430 ESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPA--SKELVG 1487
Query: 660 TRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGL 719
R + V LLE +++ L + + Q ++ +D W+++ + G GL
Sbjct: 1488 ERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL 1547
Query: 720 AEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALK 779
VQ ++K+ L + A +++ + + A + P+++ +R E L + L+
Sbjct: 1548 QAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLR 1607
Query: 780 EPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVIL 839
E R++ L ++ D + EAW+ E E S GKD ++ +LL +H +
Sbjct: 1608 EAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLE 1667
Query: 840 ENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANV 899
+ + ++E I +++ + ++E GH +E ++ R +++ +L+ R+ LE
Sbjct: 1668 QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQY 1727
Query: 900 QFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALR 959
Q + E E WI EKE + + G D E L +K F + G A
Sbjct: 1728 WLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAV 1787
Query: 960 NQ----ANACQQQQAAPV--------EGVAGEQRVMALYDFQARSPREVTMKKGDVLTLL 1007
NQ C AA + E A +M + RE+ D L
Sbjct: 1788 NQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQ 1847
Query: 1008 SSINKDWWK--------------------VEAADHQGIVPAVYVRRLAHDEFPMLPQRRR 1047
I + + + A +H + VR+L +
Sbjct: 1848 GQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAG 1907
Query: 1048 EEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWI----QEKKA 1103
E I R++++ ++ LL E+ R + + + D+L W+ + A
Sbjct: 1908 EHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGA 1967
Query: 1104 ENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR-QELN 1162
+ ++ V L + +L P L ++ LL + Q + +L
Sbjct: 1968 ADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLG 2027
Query: 1163 SRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQ 1222
+R + D + L V F +EA + + L + + GS + V+ L
Sbjct: 2028 TRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLI 2087
Query: 1223 RRHEGFER 1230
RRHE F +
Sbjct: 2088 RRHEAFRK 2095
Score = 193 bits (490), Expect = 2e-48
Identities = 131/527 (24%), Positives = 256/527 (48%), Gaps = 10/527 (1%)
Query: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILT--D 78
AE ++ +++ + + +E R Q L+ ++ ++ + D ++ W+ E+ ++ D
Sbjct: 1589 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 1648
Query: 79 KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRH 138
K ++ + +Q +KH LE V+ +++L + MGH E+ ++
Sbjct: 1649 KGKDEQSTLQ-LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDR 1707
Query: 139 LWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHK 198
L+ L EL E+ L + Q ++ +++ WI +KE +A S ELG+D+E VL +
Sbjct: 1708 LYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQE 1767
Query: 199 KFEDFQVEL-VAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQ 257
KF +F E +A R+ VNQ +E E H + ++ +N AW L L R
Sbjct: 1768 KFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRA 1827
Query: 258 KALSNAANLQRFKRDVTEAIQWIKEKE---PVLTSEDYGKDLVASEGLFHSHKGLERNLA 314
+ L+ + L +F D E I+EK P LT+ + +S + + + E +L
Sbjct: 1828 QLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS--MQRTLRAFEHDLQ 1885
Query: 315 VMSDKVKELCAKAEKLTLSHPSD-APQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYH 373
++ +V++L A +L + + A I +++++ W+ + + + +T
Sbjct: 1886 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL 1945
Query: 374 RFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETG 433
RF S +L WM+ + I A + P DV+ EVL++ HQ K E+++ + E G
Sbjct: 1946 RFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELG 2005
Query: 434 QDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMS 493
+ L+ +DE++ +++ L + E WD +Q L+ H F +++ D+W++
Sbjct: 2006 RSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLT 2065
Query: 494 RQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTAT 540
QE L++ +LG+S+ E L+++HE F +A A EE+ ++ + T
Sbjct: 2066 AQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTT 2112
Score = 165 bits (417), Expect = 6e-40
Identities = 158/771 (20%), Positives = 322/771 (41%), Gaps = 29/771 (3%)
Query: 10 VESSGPKVL----ETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDL 65
+E G +++ E A ++++ E+ + + + ++L ++ + +L
Sbjct: 1363 IEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAEL 1422
Query: 66 GKWIMEKVNILTDKSYE-DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHS 124
K ++ + L D D + + +K QS+E++V+ R + EL+ + + +
Sbjct: 1423 DKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQ-AQTAALPLEPA 1481
Query: 125 AHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSV 184
+ E + LLE E+ LL + + Q + D L W+ ++ +A
Sbjct: 1482 SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQT 1541
Query: 185 ELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNA 244
E G + + KK + + E+ A R+ EV + A A P+ ++ ++ +
Sbjct: 1542 ERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQS 1601
Query: 245 AWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFH 304
AW LR A +RQ+ L A ++++ DV E W+ E+E ++ SED GKD ++ L
Sbjct: 1602 AWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLK 1661
Query: 305 SHKGLERNLAVMSDKVKELCAKAEKLT-LSHPSDAPQIQEMKEDLVSSWEHIRALATSRY 363
H LE+ + + + +L + L + HP D+ QI + + + ++ L R
Sbjct: 1662 KHLQLEQGVENYEESIAQLSRQCRALLEMGHP-DSEQISRRQSQVDRLYVALKELGEERR 1720
Query: 364 EKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYD 423
L+ YW ++ S EL W+ EK + EL D VL ++ + E
Sbjct: 1721 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 1780
Query: 424 -DRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFY 482
+R + ++ +L+ H A+ + E + L+ W LLEL R + + H F+
Sbjct: 1781 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFF 1840
Query: 483 RDSEQVDSWMSRQEAFLEN----EDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKT 538
D+ ++ + + L + S S + L+ E + +Q ++
Sbjct: 1841 SDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 1900
Query: 539 ATKLIGDDHYDS------ENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSD 592
+ +H ++ E ++ ++ L A DA ++T L + +
Sbjct: 1901 LRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL--------RFHSQVR 1952
Query: 593 DLKNWINK-KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGG 651
DL +W++ ++ + +D+ +++ + Q + EL +L Q+ G+ ++
Sbjct: 1953 DLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNK 2012
Query: 652 HYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVT 711
+D + +L ++ + EE+ E + L + + QF A WL E +
Sbjct: 2013 SAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQ 2072
Query: 712 SEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSK 762
S + G + EV+ +R+H A AA +++ L L E+I SK
Sbjct: 2073 SRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTT-IEKIKAEQSK 2122
>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
Length = 892
Score = 219 bits (558), Expect = 3e-56
Identities = 136/503 (27%), Positives = 254/503 (50%), Gaps = 18/503 (3%)
Query: 1927 DYAFQEFNWKADVVEAWIADKETSLKTNG-NGADLGDFLTLLAKQDTLDASLQSFQQERL 1985
D+ ++F KA + EAW KE L+ A L + LL K + ++ L + Q+R+
Sbjct: 393 DHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA-HQDRV 451
Query: 1986 PEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLF 2045
+I + +L + S ++ R + +W+ L + R+ L + L+ + L+
Sbjct: 452 EQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLY 511
Query: 2046 VEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLEL 2105
+E+A +A+ NNW E E+L + ++ EI+ L HE F A+L A + +L +
Sbjct: 512 LEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGI 571
Query: 2106 DQQIKAL-------GVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEM 2158
++ + ++PYT +T + + W H+ ++ R+Q L +E ARQ N +
Sbjct: 572 HNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERL 631
Query: 2159 CQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218
++F A+ WI +T+ + ++ GTLE QL ++ +K I K ++ ++
Sbjct: 632 RKQFGAQANVIGPWI-QTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEG 690
Query: 2219 LGDNLEDALILDIK---YSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKE 2275
+++ALI D K Y+ + W+QL R + +E QI +D KG+S+E + E
Sbjct: 691 DHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNE 750
Query: 2276 FSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVS 2335
F + HFD + +G L +EF++CL L Y + + + E +F + + VDP R G V+
Sbjct: 751 FRASFNHFDRDHSGTLGPEEFKACLISLGY--DIGNDPQGEAEFARIMSIVDPNRLGVVT 808
Query: 2336 LEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQY 2395
+ + F+ +E+ + ++D++ +F+ LA K+YIT +++++ L P+Q +C M Y
Sbjct: 809 FQAFIDFM-SRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPY 867
Query: 2396 MDPRGRSHLSGYDYVGFTNSYFG 2418
P S DY+ F+ + +G
Sbjct: 868 TGP--DSVPGALDYMSFSTALYG 888
Score = 68.2 bits (165), Expect = 1e-10
Identities = 97/489 (19%), Positives = 193/489 (39%), Gaps = 84/489 (17%)
Query: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWI-------QEKKAENTG 1107
Q+ E N+ +L + +L++ Y + A D+LEWI + + ENT
Sbjct: 253 QKAETAANRICKVL-AVNQENEQLMEDYEKL-----ASDLLEWIRRTIPWLENRVPENT- 305
Query: 1108 VELDDVWELQKKFDEFQK------------------DLNTNEPRLRDINKVADDLLFEGL 1149
+ +Q+K ++F+ + NT + +LR N+ A
Sbjct: 306 -----MHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPA-------- 352
Query: 1150 LTPEGAQIRQELNSRWGSLQR--------LADEQRQLLGSAHAVEVFHREADDTKEQIEK 1201
P ++ ++N+ WG L++ L +E R+L H E F ++A + +
Sbjct: 353 FMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDG 412
Query: 1202 KCQALSAAD-PGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDL 1260
K L D + L ++AL ++HE FE DL D+V + A+ L+E + +
Sbjct: 413 KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSV 472
Query: 1261 QRQKMELNEAWEDLQGRTKDRKESLNEAQK-------FYL-FLSKARDLQNWISSIGGMV 1312
+ ++ + W++L T+ R+E+L +K YL + +A NW+ +
Sbjct: 473 NARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDL 532
Query: 1313 SSQELAEDLTGIEILLERHQEHRA---DMEAEAPTFQALEDFSAELIDSGH----HASPE 1365
+ + I+ L H++ +A D + E + + ++++ + H +P
Sbjct: 533 QDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPY 592
Query: 1366 IEKKLQAVKLERDDLEKAWEKRKKILDQCLELQ--------MFQGNCDQVESWMVARENS 1417
Q + + D + + +R + L + Q F + + W+ +
Sbjct: 593 TTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEE 652
Query: 1418 LRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEH----FAESLIADE---HYAKEE 1470
+ +LE + +K+I + KI LE E+LI D +Y E
Sbjct: 653 IGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEH 712
Query: 1471 IATRLQRVL 1479
I +++L
Sbjct: 713 IRVGWEQLL 721
Score = 57.0 bits (136), Expect = 2e-07
Identities = 54/234 (23%), Positives = 95/234 (40%), Gaps = 35/234 (14%)
Query: 161 QQYVQECADILEWI-------------GDKEAIATSVELGEDWERTEVLHKKFEDFQVEL 207
+ Y + +D+LEWI A+ +E D+ R K E Q+E
Sbjct: 277 EDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLE- 335
Query: 208 VAKEGRVVEVNQYANECAEENHPD-LPLIQSKQNEVNAAWERLRGLA----------LQR 256
+ N + N P +P +++N AW L + ++R
Sbjct: 336 -------INFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388
Query: 257 QKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVAS-EGLFHSHKGLERNLAV 315
+ L + A R K + EA W KE +L +DY ++ + L H+ E +LA
Sbjct: 389 LERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446
Query: 316 MSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQAT 369
D+V+++ A A++L D+P + + + W+++ AL R E L+ T
Sbjct: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
Score = 54.7 bits (130), Expect = 1e-06
Identities = 32/140 (22%), Positives = 66/140 (47%), Gaps = 10/140 (7%)
Query: 575 RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD--IQNLKSRVQKQQVFEKELAV 632
RRL + L +K + + + W + K+ + +DY+ + +K+ ++K + FE +LA
Sbjct: 387 RRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446
Query: 633 NKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQ---- 688
++ ++E I QE+ E +Y S +V R ++ W+ L T+++ L +
Sbjct: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506
Query: 689 ----QLQFENNAEDLQRWLE 704
L++ A W+E
Sbjct: 507 IDQLYLEYAKRAAPFNNWME 526
Score = 52.8 bits (125), Expect = 4e-06
Identities = 46/186 (24%), Positives = 85/186 (45%), Gaps = 6/186 (3%)
Query: 608 EDYKDIQNLKSRVQKQQVFEKELAVNKTQLE-NIQKTGQEMIEGGHYASD--NVTTRLSE 664
ED++D + L + Q+ + E+ N Q + + M G SD N L +
Sbjct: 314 EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQ 373
Query: 665 VASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKG-LAEVQ 723
V +EE L ++ +L ++ F A + W + E + +DY L+E++
Sbjct: 374 VEKGYEEWLLNEIRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLRQKDYETATLSEIK 431
Query: 724 NRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLA 783
L+KH ES +AA QD+V+ + +A E+ + DS + AR + + +++ L
Sbjct: 432 ALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ 491
Query: 784 TRKKKL 789
R++ L
Sbjct: 492 KRREAL 497
Score = 52.0 bits (123), Expect = 7e-06
Identities = 51/254 (20%), Positives = 104/254 (40%), Gaps = 25/254 (9%)
Query: 1717 QFFQDLDDEESWIEEKLIRVSSQDYGR-DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775
+F Q E+W + K + +DY L ++ LLKKH+ E +L AH+ ++ + +
Sbjct: 398 KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAI 457
Query: 1776 AEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLE--------YLQFMQN 1827
A++L + + R + + W+ L L + R LE + + YL++ +
Sbjct: 458 AQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKR 517
Query: 1828 AEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQG-EDIL 1886
A W+ T+ Q L HE + + + + + G + +
Sbjct: 518 AAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK--ATLPDADKERLAILGIHNEV 575
Query: 1887 NKVLQEESQN------------KEISSKIEALNEKTPSLAKAIA-AWKLQLEDDYAFQEF 1933
+K++Q N +EI+ K + + + P +A+ Q ++ ++F
Sbjct: 576 SKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQF 635
Query: 1934 NWKADVVEAWIADK 1947
+A+V+ WI K
Sbjct: 636 GAQANVIGPWIQTK 649
Score = 52.0 bits (123), Expect = 7e-06
Identities = 60/277 (21%), Positives = 112/277 (40%), Gaps = 42/277 (15%)
Query: 489 DSWMSRQEAFLENEDLGNS-LGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDH 547
++W +EA L +D + L +ALL+KHE FE A ++++ + A +L D+
Sbjct: 407 EAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDY 466
Query: 548 YDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDL-----------KN 596
YDS ++ A + + D L RR L+ + +KL E D L N
Sbjct: 467 YDSPSVNARCQKICDQWDNLGALTQKRREALERT---EKLLETIDQLYLEYAKRAAPFNN 523
Query: 597 WINKKKKLADD----EDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGH 652
W+ + D ++IQ L + ++ + + + + I ++++ H
Sbjct: 524 WMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH 583
Query: 653 --YASDNVTTRLS--EVASLWEELLE--------ATKQKGTQLHEANQQLQFENNAEDLQ 700
A N T ++ E+ W+ + + T++ Q H + QF A +
Sbjct: 584 VNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIG 643
Query: 701 RWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVA 737
W+ Q E+ G+ E+ HG LE ++
Sbjct: 644 PWI-----QTKMEEIGRISIEM------HGTLEDQLS 669
Score = 48.1 bits (113), Expect = 1e-04
Identities = 47/265 (17%), Positives = 109/265 (41%), Gaps = 29/265 (10%)
Query: 1378 DDLEKAWE-------KRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDD--KSSLDS 1428
+ +EK +E +R + LD E F+ E+W +E LR D ++L
Sbjct: 372 EQVEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSE 429
Query: 1429 LEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKA- 1487
++AL+KK + + + A + ++ + A+ L ++Y + R Q++ D+W L A
Sbjct: 430 IKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGAL 489
Query: 1488 -----QLIDERTKLGDYANLKQFYRDLEE--------LEEWISEMLPTACDESYKDATNI 1534
+ ++ KL + Q Y + + +E + ++ T + ++ +
Sbjct: 490 TQKRREALERTEKL--LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGL 547
Query: 1535 QRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACD--GNEEAMKEQLEQLKEHWDHL 1592
+ + + + D + G+ N + +++ + G +++ WDH+
Sbjct: 548 TTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHV 607
Query: 1593 LERTNDKGKKLNEASRQQRFNTSIR 1617
+ + + L E +Q+ N +R
Sbjct: 608 RQLVPRRDQALTEEHARQQHNERLR 632
Score = 46.6 bits (109), Expect = 3e-04
Identities = 83/460 (18%), Positives = 173/460 (37%), Gaps = 56/460 (12%)
Query: 50 EDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTN-IQGKYQKHQSLEA-----EVQT 103
E+ ++ +++ A DL +WI + L ++ E+ + +Q K + + +VQ
Sbjct: 271 ENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQE 330
Query: 104 KSRLMSELEKTREERFTMGHSAHEETKAH-IEELRHLWDLLLELTLEKGDQLLRALKFQQ 162
K +L + + A ++ + ++ + W L ++ + LL ++ +
Sbjct: 331 KCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLE 390
Query: 163 YVQECADILE--------WIGDKEAIATSVELGEDWERT-----EVLHKKFEDFQVELVA 209
+ A+ W KEA+ +D+E + L KK E F+ +L A
Sbjct: 391 RLDHLAEKFRQKASIHEAWTDGKEAMLRQ----KDYETATLSEIKALLKKHEAFESDLAA 446
Query: 210 KEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANL--- 266
+ RV ++ A E E ++ D P + ++ ++ W+ L L +R++AL L
Sbjct: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506
Query: 267 -----QRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVK 321
+ + W++ L + +GL +H E+ A + D K
Sbjct: 507 IDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAH---EQFKATLPDADK 563
Query: 322 ELCA------KAEKLTLSH----PSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATY- 370
E A + K+ ++ P +++ W+H+R L R + L +
Sbjct: 564 ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHA 623
Query: 371 -------WYHRFSSDFDELSGWMNEKTAAINADELPTDVAGG-EVLLDRHQQHKHEIDSY 422
+F + + + W+ K I + ++ G E L +Q++ I +Y
Sbjct: 624 RQQHNERLRKQFGAQANVIGPWIQTKMEEIG--RISIEMHGTLEDQLSHLRQYEKSIVNY 681
Query: 423 DDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALL 462
+ + Q + A + ME + W LL
Sbjct: 682 KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
Score = 46.6 bits (109), Expect = 3e-04
Identities = 38/190 (20%), Positives = 82/190 (43%), Gaps = 11/190 (5%)
Query: 1582 LEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKD-QARDLA 1640
LEQ+++ ++ L + ++L+ + + R SI E W E +L KD + L+
Sbjct: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIH--EAWTDGKEAMLRQKDYETATLS 428
Query: 1641 SAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQE 1700
LLKKH+ E ++ A +D ++ + +A++L ++ + + + ++ N+
Sbjct: 429 EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGA 488
Query: 1701 LAAAHHEKLKEAYALFQFFQDLDDE--------ESWIEEKLIRVSSQDYGRDLQGVQNLL 1752
L E L+ L + L E +W+E + + ++ +Q L
Sbjct: 489 LTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLT 548
Query: 1753 KKHKRLEGEL 1762
H++ + L
Sbjct: 549 TAHEQFKATL 558
Score = 45.4 bits (106), Expect = 7e-04
Identities = 78/455 (17%), Positives = 178/455 (39%), Gaps = 48/455 (10%)
Query: 262 NAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVK 321
N ++ +++ ++ ++WI+ P L + + A + + R KV+
Sbjct: 272 NEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRR--LHKPPKVQ 329
Query: 322 ELC-------AKAEKLTLSH-PSDAPQIQEMKEDLVSSWEHIRALATSRYEKL------- 366
E C KL LS+ P+ P M D+ ++W + + E L
Sbjct: 330 EKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRL 389
Query: 367 -QATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGG-EVLLDRHQQHKHEIDSYDD 424
+ + +F W + K A + + T + LL +H+ + ++ ++ D
Sbjct: 390 ERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQD 449
Query: 425 RFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYE------QCLD- 477
R + Q+L ++ S V + + + + W L L +R E + +D
Sbjct: 450 RVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQ 509
Query: 478 FHLFY-RDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEK---II 533
+L Y + + ++WM L++ + +++ + L HE F+ +++ I+
Sbjct: 510 LYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAIL 569
Query: 534 TVDKTATKLI--------GDDHYDSENIKAIRD------GLLARRD-ALREKAATRRRLL 578
+ +K++ G + Y + + I L+ RRD AL E+ A ++
Sbjct: 570 GIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQH-- 627
Query: 579 KESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLE 638
L ++ ++ + WI K + + L+ ++ + +EK + K +++
Sbjct: 628 -NERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKID 686
Query: 639 NIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELL 673
++ Q + E + + + + + WE+LL
Sbjct: 687 QLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
Score = 43.1 bits (100), Expect = 0.003
Identities = 63/293 (21%), Positives = 118/293 (40%), Gaps = 30/293 (10%)
Query: 1985 LPEITDLKDKLISAQHNQSKAIEERYAALLKRWE--QLLEASAVHRQKLLEKQLPLQKAE 2042
+P++ D +D ++ KAI ++ + Q E +A K+L Q+ E
Sbjct: 218 IPKMLDAED-IVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVN---QENE 273
Query: 2043 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCL 2102
L ++ AS L W + L V +++ ++Q +D D+ + KC
Sbjct: 274 QLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQ 333
Query: 2103 LE-----LDQQIKALGVPS-SPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNF 2156
LE L +++ P+ P V + W L + + E+ L E R +
Sbjct: 334 LEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLD 393
Query: 2157 EMCQEFEQNASTFLQWI-----------LETRAYFLDGSLLKETGTLESQLEANKRKQKE 2205
+ ++F Q AS W ET +LLK+ ES L A++ + ++
Sbjct: 394 HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQ 453
Query: 2206 IQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQ 2258
I A+ ++L ++ + D+ ++ + I QWD L L + + LE+
Sbjct: 454 IAAIAQELNEL-----DYYDSPSVNARCQKI--CDQWDNLGALTQKRREALER 499
Score = 33.5 bits (75), Expect = 2.6
Identities = 52/240 (21%), Positives = 91/240 (37%), Gaps = 35/240 (14%)
Query: 738 ARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQL 797
AR D+ I+T +++++ + A + V E L +KL L L+
Sbjct: 231 ARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDL-LEW 289
Query: 798 ICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQE------ 851
I R W++ P T + + L + H+ P++QE
Sbjct: 290 IRRTIP----WLENRVPENTMHAMQQKLEDFRDYRRLHK---------PPKVQEKCQLEI 336
Query: 852 ----------ITERGNKMVEEGHFAAE--DVASRVKSLNQNMESLRARAARRQNDLEANV 899
++ R M EG ++ + ++ + + E RR L+
Sbjct: 337 NFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLA 396
Query: 900 QFQQYLADLHEAETWIREKEPIVDNTNYG-ADEEAAGALLKKHEAFLLDLNSFGDSMKAL 958
+ + A +HEA W KE ++ +Y A ALLKKHEAF DL + D ++ +
Sbjct: 397 EKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
Length = 887
Score = 217 bits (552), Expect = 1e-55
Identities = 135/503 (26%), Positives = 250/503 (49%), Gaps = 23/503 (4%)
Query: 1927 DYAFQEFNWKADVVEAWIADKETSLKTNG-NGADLGDFLTLLAKQDTLDASLQSFQQERL 1985
D+ ++F KA + EAW KE L+ A L + LL K + ++ L + Q+R+
Sbjct: 393 DHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA-HQDRV 451
Query: 1986 PEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLF 2045
+I + +L + S ++ R + +W+ L + R+ L + L+ + L+
Sbjct: 452 EQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLY 511
Query: 2046 VEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLEL 2105
+E+A +A+ NNW E E+L + ++ EI+ L HE F A+L A + +L +
Sbjct: 512 LEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGI 571
Query: 2106 DQQIKAL-------GVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEM 2158
++ + ++PYT +T + + W H+ ++ R+Q L +E ARQ N +
Sbjct: 572 HNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERL 631
Query: 2159 CQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218
++F A+ WI +T+ + ++ GTLE QL ++ +K I K ++ ++
Sbjct: 632 RKQFGAQANVIGPWI-QTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEG 690
Query: 2219 LGDNLEDALILDIK---YSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKE 2275
+++ALI D K Y+ + W+QL R + +E QI +D KG+S+E + E
Sbjct: 691 DHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNE 750
Query: 2276 FSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVS 2335
F + HFD TG + +FR+CL + Y + E +F + + VDP R G V+
Sbjct: 751 FRASFNHFDRKKTGMMDTDDFRACLISMGYNM-------GEAEFARIMSIVDPNRLGVVT 803
Query: 2336 LEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQY 2395
+ + F+ +E+ + ++D++ +F+ LA K+YIT +++++ L P+Q +C M Y
Sbjct: 804 FQAFIDFM-SRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPY 862
Query: 2396 MDPRGRSHLSGYDYVGFTNSYFG 2418
P S DY+ F+ + +G
Sbjct: 863 TGP--DSVPGALDYMSFSTALYG 883
Score = 68.2 bits (165), Expect = 1e-10
Identities = 97/489 (19%), Positives = 193/489 (39%), Gaps = 84/489 (17%)
Query: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWI-------QEKKAENTG 1107
Q+ E N+ +L + +L++ Y + A D+LEWI + + ENT
Sbjct: 253 QKAETAANRICKVL-AVNQENEQLMEDYEKL-----ASDLLEWIRRTIPWLENRVPENT- 305
Query: 1108 VELDDVWELQKKFDEFQK------------------DLNTNEPRLRDINKVADDLLFEGL 1149
+ +Q+K ++F+ + NT + +LR N+ A
Sbjct: 306 -----MHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPA-------- 352
Query: 1150 LTPEGAQIRQELNSRWGSLQR--------LADEQRQLLGSAHAVEVFHREADDTKEQIEK 1201
P ++ ++N+ WG L++ L +E R+L H E F ++A + +
Sbjct: 353 FMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDG 412
Query: 1202 KCQALSAAD-PGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDL 1260
K L D + L ++AL ++HE FE DL D+V + A+ L+E + +
Sbjct: 413 KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSV 472
Query: 1261 QRQKMELNEAWEDLQGRTKDRKESLNEAQK-------FYL-FLSKARDLQNWISSIGGMV 1312
+ ++ + W++L T+ R+E+L +K YL + +A NW+ +
Sbjct: 473 NARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDL 532
Query: 1313 SSQELAEDLTGIEILLERHQEHRA---DMEAEAPTFQALEDFSAELIDSGH----HASPE 1365
+ + I+ L H++ +A D + E + + ++++ + H +P
Sbjct: 533 QDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPY 592
Query: 1366 IEKKLQAVKLERDDLEKAWEKRKKILDQCLELQ--------MFQGNCDQVESWMVARENS 1417
Q + + D + + +R + L + Q F + + W+ +
Sbjct: 593 TTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEE 652
Query: 1418 LRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEH----FAESLIADE---HYAKEE 1470
+ +LE + +K+I + KI LE E+LI D +Y E
Sbjct: 653 IGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEH 712
Query: 1471 IATRLQRVL 1479
I +++L
Sbjct: 713 IRVGWEQLL 721
Score = 57.0 bits (136), Expect = 2e-07
Identities = 54/234 (23%), Positives = 95/234 (40%), Gaps = 35/234 (14%)
Query: 161 QQYVQECADILEWI-------------GDKEAIATSVELGEDWERTEVLHKKFEDFQVEL 207
+ Y + +D+LEWI A+ +E D+ R K E Q+E
Sbjct: 277 EDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLE- 335
Query: 208 VAKEGRVVEVNQYANECAEENHPD-LPLIQSKQNEVNAAWERLRGLA----------LQR 256
+ N + N P +P +++N AW L + ++R
Sbjct: 336 -------INFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388
Query: 257 QKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVAS-EGLFHSHKGLERNLAV 315
+ L + A R K + EA W KE +L +DY ++ + L H+ E +LA
Sbjct: 389 LERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446
Query: 316 MSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQAT 369
D+V+++ A A++L D+P + + + W+++ AL R E L+ T
Sbjct: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
Score = 54.7 bits (130), Expect = 1e-06
Identities = 32/140 (22%), Positives = 66/140 (47%), Gaps = 10/140 (7%)
Query: 575 RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD--IQNLKSRVQKQQVFEKELAV 632
RRL + L +K + + + W + K+ + +DY+ + +K+ ++K + FE +LA
Sbjct: 387 RRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446
Query: 633 NKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQ---- 688
++ ++E I QE+ E +Y S +V R ++ W+ L T+++ L +
Sbjct: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506
Query: 689 ----QLQFENNAEDLQRWLE 704
L++ A W+E
Sbjct: 507 IDQLYLEYAKRAAPFNNWME 526
Score = 52.8 bits (125), Expect = 4e-06
Identities = 46/186 (24%), Positives = 85/186 (45%), Gaps = 6/186 (3%)
Query: 608 EDYKDIQNLKSRVQKQQVFEKELAVNKTQLE-NIQKTGQEMIEGGHYASD--NVTTRLSE 664
ED++D + L + Q+ + E+ N Q + + M G SD N L +
Sbjct: 314 EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQ 373
Query: 665 VASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKG-LAEVQ 723
V +EE L ++ +L ++ F A + W + E + +DY L+E++
Sbjct: 374 VEKGYEEWLLNEIRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLRQKDYETATLSEIK 431
Query: 724 NRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLA 783
L+KH ES +AA QD+V+ + +A E+ + DS + AR + + +++ L
Sbjct: 432 ALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ 491
Query: 784 TRKKKL 789
R++ L
Sbjct: 492 KRREAL 497
Score = 52.0 bits (123), Expect = 7e-06
Identities = 51/254 (20%), Positives = 104/254 (40%), Gaps = 25/254 (9%)
Query: 1717 QFFQDLDDEESWIEEKLIRVSSQDYGR-DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775
+F Q E+W + K + +DY L ++ LLKKH+ E +L AH+ ++ + +
Sbjct: 398 KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAI 457
Query: 1776 AEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLE--------YLQFMQN 1827
A++L + + R + + W+ L L + R LE + + YL++ +
Sbjct: 458 AQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKR 517
Query: 1828 AEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQG-EDIL 1886
A W+ T+ Q L HE + + + + + G + +
Sbjct: 518 AAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK--ATLPDADKERLAILGIHNEV 575
Query: 1887 NKVLQEESQN------------KEISSKIEALNEKTPSLAKAIA-AWKLQLEDDYAFQEF 1933
+K++Q N +EI+ K + + + P +A+ Q ++ ++F
Sbjct: 576 SKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQF 635
Query: 1934 NWKADVVEAWIADK 1947
+A+V+ WI K
Sbjct: 636 GAQANVIGPWIQTK 649
Score = 52.0 bits (123), Expect = 7e-06
Identities = 60/277 (21%), Positives = 112/277 (40%), Gaps = 42/277 (15%)
Query: 489 DSWMSRQEAFLENEDLGNS-LGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDH 547
++W +EA L +D + L +ALL+KHE FE A ++++ + A +L D+
Sbjct: 407 EAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDY 466
Query: 548 YDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDL-----------KN 596
YDS ++ A + + D L RR L+ + +KL E D L N
Sbjct: 467 YDSPSVNARCQKICDQWDNLGALTQKRREALERT---EKLLETIDQLYLEYAKRAAPFNN 523
Query: 597 WINKKKKLADD----EDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGH 652
W+ + D ++IQ L + ++ + + + + I ++++ H
Sbjct: 524 WMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH 583
Query: 653 --YASDNVTTRLS--EVASLWEELLE--------ATKQKGTQLHEANQQLQFENNAEDLQ 700
A N T ++ E+ W+ + + T++ Q H + QF A +
Sbjct: 584 VNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIG 643
Query: 701 RWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVA 737
W+ Q E+ G+ E+ HG LE ++
Sbjct: 644 PWI-----QTKMEEIGRISIEM------HGTLEDQLS 669
Score = 48.1 bits (113), Expect = 1e-04
Identities = 47/265 (17%), Positives = 109/265 (41%), Gaps = 29/265 (10%)
Query: 1378 DDLEKAWE-------KRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDD--KSSLDS 1428
+ +EK +E +R + LD E F+ E+W +E LR D ++L
Sbjct: 372 EQVEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSE 429
Query: 1429 LEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKA- 1487
++AL+KK + + + A + ++ + A+ L ++Y + R Q++ D+W L A
Sbjct: 430 IKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGAL 489
Query: 1488 -----QLIDERTKLGDYANLKQFYRDLEE--------LEEWISEMLPTACDESYKDATNI 1534
+ ++ KL + Q Y + + +E + ++ T + ++ +
Sbjct: 490 TQKRREALERTEKL--LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGL 547
Query: 1535 QRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACD--GNEEAMKEQLEQLKEHWDHL 1592
+ + + + D + G+ N + +++ + G +++ WDH+
Sbjct: 548 TTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHV 607
Query: 1593 LERTNDKGKKLNEASRQQRFNTSIR 1617
+ + + L E +Q+ N +R
Sbjct: 608 RQLVPRRDQALTEEHARQQHNERLR 632
Score = 46.6 bits (109), Expect = 3e-04
Identities = 83/460 (18%), Positives = 173/460 (37%), Gaps = 56/460 (12%)
Query: 50 EDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTN-IQGKYQKHQSLEA-----EVQT 103
E+ ++ +++ A DL +WI + L ++ E+ + +Q K + + +VQ
Sbjct: 271 ENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQE 330
Query: 104 KSRLMSELEKTREERFTMGHSAHEETKAH-IEELRHLWDLLLELTLEKGDQLLRALKFQQ 162
K +L + + A ++ + ++ + W L ++ + LL ++ +
Sbjct: 331 KCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLE 390
Query: 163 YVQECADILE--------WIGDKEAIATSVELGEDWERT-----EVLHKKFEDFQVELVA 209
+ A+ W KEA+ +D+E + L KK E F+ +L A
Sbjct: 391 RLDHLAEKFRQKASIHEAWTDGKEAMLRQ----KDYETATLSEIKALLKKHEAFESDLAA 446
Query: 210 KEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANL--- 266
+ RV ++ A E E ++ D P + ++ ++ W+ L L +R++AL L
Sbjct: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506
Query: 267 -----QRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVK 321
+ + W++ L + +GL +H E+ A + D K
Sbjct: 507 IDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAH---EQFKATLPDADK 563
Query: 322 ELCA------KAEKLTLSH----PSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATY- 370
E A + K+ ++ P +++ W+H+R L R + L +
Sbjct: 564 ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHA 623
Query: 371 -------WYHRFSSDFDELSGWMNEKTAAINADELPTDVAGG-EVLLDRHQQHKHEIDSY 422
+F + + + W+ K I + ++ G E L +Q++ I +Y
Sbjct: 624 RQQHNERLRKQFGAQANVIGPWIQTKMEEIG--RISIEMHGTLEDQLSHLRQYEKSIVNY 681
Query: 423 DDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALL 462
+ + Q + A + ME + W LL
Sbjct: 682 KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
Score = 46.6 bits (109), Expect = 3e-04
Identities = 38/190 (20%), Positives = 82/190 (43%), Gaps = 11/190 (5%)
Query: 1582 LEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKD-QARDLA 1640
LEQ+++ ++ L + ++L+ + + R SI E W E +L KD + L+
Sbjct: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIH--EAWTDGKEAMLRQKDYETATLS 428
Query: 1641 SAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQE 1700
LLKKH+ E ++ A +D ++ + +A++L ++ + + + ++ N+
Sbjct: 429 EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGA 488
Query: 1701 LAAAHHEKLKEAYALFQFFQDLDDE--------ESWIEEKLIRVSSQDYGRDLQGVQNLL 1752
L E L+ L + L E +W+E + + ++ +Q L
Sbjct: 489 LTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLT 548
Query: 1753 KKHKRLEGEL 1762
H++ + L
Sbjct: 549 TAHEQFKATL 558
Score = 45.4 bits (106), Expect = 7e-04
Identities = 78/455 (17%), Positives = 178/455 (39%), Gaps = 48/455 (10%)
Query: 262 NAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVK 321
N ++ +++ ++ ++WI+ P L + + A + + R KV+
Sbjct: 272 NEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRR--LHKPPKVQ 329
Query: 322 ELC-------AKAEKLTLSH-PSDAPQIQEMKEDLVSSWEHIRALATSRYEKL------- 366
E C KL LS+ P+ P M D+ ++W + + E L
Sbjct: 330 EKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRL 389
Query: 367 -QATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGG-EVLLDRHQQHKHEIDSYDD 424
+ + +F W + K A + + T + LL +H+ + ++ ++ D
Sbjct: 390 ERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQD 449
Query: 425 RFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYE------QCLD- 477
R + Q+L ++ S V + + + + W L L +R E + +D
Sbjct: 450 RVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQ 509
Query: 478 FHLFY-RDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEK---II 533
+L Y + + ++WM L++ + +++ + L HE F+ +++ I+
Sbjct: 510 LYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAIL 569
Query: 534 TVDKTATKLI--------GDDHYDSENIKAIRD------GLLARRD-ALREKAATRRRLL 578
+ +K++ G + Y + + I L+ RRD AL E+ A ++
Sbjct: 570 GIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQH-- 627
Query: 579 KESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLE 638
L ++ ++ + WI K + + L+ ++ + +EK + K +++
Sbjct: 628 -NERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKID 686
Query: 639 NIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELL 673
++ Q + E + + + + + WE+LL
Sbjct: 687 QLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
Score = 43.1 bits (100), Expect = 0.003
Identities = 63/293 (21%), Positives = 118/293 (40%), Gaps = 30/293 (10%)
Query: 1985 LPEITDLKDKLISAQHNQSKAIEERYAALLKRWE--QLLEASAVHRQKLLEKQLPLQKAE 2042
+P++ D +D ++ KAI ++ + Q E +A K+L Q+ E
Sbjct: 218 IPKMLDAED-IVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVN---QENE 273
Query: 2043 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCL 2102
L ++ AS L W + L V +++ ++Q +D D+ + KC
Sbjct: 274 QLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQ 333
Query: 2103 LE-----LDQQIKALGVPS-SPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNF 2156
LE L +++ P+ P V + W L + + E+ L E R +
Sbjct: 334 LEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLD 393
Query: 2157 EMCQEFEQNASTFLQWI-----------LETRAYFLDGSLLKETGTLESQLEANKRKQKE 2205
+ ++F Q AS W ET +LLK+ ES L A++ + ++
Sbjct: 394 HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQ 453
Query: 2206 IQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQ 2258
I A+ ++L ++ + D+ ++ + I QWD L L + + LE+
Sbjct: 454 IAAIAQELNEL-----DYYDSPSVNARCQKI--CDQWDNLGALTQKRREALER 499
Score = 33.5 bits (75), Expect = 2.6
Identities = 52/240 (21%), Positives = 91/240 (37%), Gaps = 35/240 (14%)
Query: 738 ARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQL 797
AR D+ I+T +++++ + A + V E L +KL L L+
Sbjct: 231 ARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDL-LEW 289
Query: 798 ICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQE------ 851
I R W++ P T + + L + H+ P++QE
Sbjct: 290 IRRTIP----WLENRVPENTMHAMQQKLEDFRDYRRLHK---------PPKVQEKCQLEI 336
Query: 852 ----------ITERGNKMVEEGHFAAE--DVASRVKSLNQNMESLRARAARRQNDLEANV 899
++ R M EG ++ + ++ + + E RR L+
Sbjct: 337 NFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLA 396
Query: 900 QFQQYLADLHEAETWIREKEPIVDNTNYG-ADEEAAGALLKKHEAFLLDLNSFGDSMKAL 958
+ + A +HEA W KE ++ +Y A ALLKKHEAF DL + D ++ +
Sbjct: 397 EKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 214 bits (546), Expect = 6e-55
Identities = 443/2242 (19%), Positives = 900/2242 (40%), Gaps = 244/2242 (10%)
Query: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQV-FKRDADDLGKWIMEKVNILTD-KSY 81
+Q + + T + +F ++V ER KL++S + +K + L WI + N L + K
Sbjct: 2868 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2927
Query: 82 EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHE----ETKAHIE--- 134
DP + K +SL+ E+ ++ L T ++ E E K+ I+
Sbjct: 2928 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2987
Query: 135 ---ELRHLWDLLLELTLEKGDQLLRALKFQQYVQECA----DILEWIGDK---------- 177
E H LE +K + K + +CA DI + +G +
Sbjct: 2988 MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML 3047
Query: 178 -------EAIATSVELGEDWERTEVLH----KKFED--FQVELVAKEGRVVEVNQYANEC 224
+A+ V+L + + V+ K D QVE +A+E + +Q +E
Sbjct: 3048 QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL--SQQVDEK 3105
Query: 225 AEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKE 284
L I QN + + + + + + ++ ++K+ E
Sbjct: 3106 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLE 3165
Query: 285 PVLTSEDYG----KDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQ 340
++ S D K ++A+E G++R+L +S + +L +A+
Sbjct: 3166 ALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR---------- 3215
Query: 341 IQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPT 400
+E E + E Y KL+ + + + +E G + +T IN
Sbjct: 3216 -EEQVEGTIKRLEEF-------YSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMF 3267
Query: 401 DVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN--ANHEASDEVREKMEILDNNW 458
V K EI+ + Q + GQ L+ A ++ + ++ ++ W
Sbjct: 3268 KVF-----------QKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3316
Query: 459 TALLELWDERHRQYEQCLDFHLFYRDS-EQVDSWMSRQEAFLENEDLGNS-LGSAEALLQ 516
L + +R Q ++ L ++D+ E + SWM E + N+ ++ +A +Q
Sbjct: 3317 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3376
Query: 517 KHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLL--ARRDALREKAATR 574
+ + + ++ + + + K I ++ +K ++ L +R +AL KA TR
Sbjct: 3377 EQKLLQRLLDDRKSTVEVIKREGEK-IATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3435
Query: 575 RRLLKE-SLLLQKLYEDSDDLKNWINK-KKKLADDEDY-KDIQNLKSRVQKQQVFEKELA 631
R L+ S++ Q+ +E + L W+ +K+L + E L+ ++ + + E ++
Sbjct: 3436 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3495
Query: 632 VNKTQLENIQKTGQEM-IEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEA--NQ 688
+ L GQ + + D V ++L + E+ E + + L +A N
Sbjct: 3496 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3555
Query: 689 QLQFENNAEDLQRWLEDVEWQVTS---EDYG-KGLAEVQNRLRKHGLLESAVAARQDQVD 744
++ E+ E L WL +V +++ +DY +GL + Q+ LR +L+ + R+ VD
Sbjct: 3556 KIFGEDEVE-LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR---VLQEDILLRKQNVD 3611
Query: 745 --ILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT 802
+L L + G + I+ + E++ R++ + + K L L L T
Sbjct: 3612 QALLNGLELLKQTTGD-EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHST 3670
Query: 803 EDEEA-WIQETEPSATS--TYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKM 859
+E W+ + E S T + K AS+ + R + + + +++ + + E + +
Sbjct: 3671 HEELCTWLDKVEVELLSYETQVLKGEEASQAQM-RPKELKKEAKNNKALLDSLNEVSSAL 3729
Query: 860 VEEGHFAA-EDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAE-TWIRE 917
+E + A E + V N+ + ++ +++A + Q +AE +WI E
Sbjct: 3730 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITE 3789
Query: 918 KEP-IVDNTNYGADEEAAGALLKKHEAFLLDL----NSFGDSMKALRNQANACQQQQAAP 972
E ++ + +++ A L+ + F +++ + D +K+ AC +++
Sbjct: 3790 TEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQS 3849
Query: 973 VEGVAGEQRVMALYDF--QARSPREVTMKKGDVLTLLSSINKDWWKVEA-----ADHQGI 1025
++ +V+ YD Q S R + +++ L +N+ W E + Q I
Sbjct: 3850 MKKKL--DKVLKNYDTICQINSERYLQLERAQSL-----VNQFWETYEELWPWLTETQSI 3902
Query: 1026 VPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRS---LLDRAEERRRRLLQRY 1082
+ + L ++ + R+ I + + I+ ++ LL+ + + ++Y
Sbjct: 3903 ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKY 3962
Query: 1083 NEFLLAYEAGDMLEWIQEKKAENTGVELDDV----WELQKKFDEFQKDLNTNEPRLRDIN 1138
A D L ++ + V LD+ + K D+ + L RLR
Sbjct: 3963 -------VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPP 4015
Query: 1139 KVADDL--LFEGLLTPEGAQIRQE-LNSRWGSLQRLADEQRQLLG------SAHAVE--- 1186
++ ++ + E + + + E L + +L++ +E G SA AV+
Sbjct: 4016 SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKL 4075
Query: 1187 -------------VFHREAD--DTKEQIEKK-CQALSAA--------------DPGSDLF 1216
V REA D E EK C +S DPG D
Sbjct: 4076 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 4135
Query: 1217 SVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKM-ELNEAWEDLQ 1275
V+ Q E ++ L +++ I+ L + + + + ++ + ELN AW+ L
Sbjct: 4136 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLN 4195
Query: 1276 GRTKDRKESLNEA-QKFYLFLSKARDLQNWISSIGGMVSSQE-LAEDLTGIEILLERHQE 1333
KDR + L EA Q + + + +W+ GG ++S + DL ++ +E ++
Sbjct: 4196 KAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQ 4255
Query: 1334 HRADMEAEAPTFQALEDFSAELI------DSGHHASPEIEKKLQAVKLERDDLEKAWEKR 1387
+++ + + L + AEL+ +S H ++ L +KL D LE+ R
Sbjct: 4256 FKSEAYQQQIEMERL-NHQAELLLKKVTEESDKHT---VQDPLMELKLIWDSLEERIINR 4311
Query: 1388 K-KILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLD--SLEALMKKRDDLDKAIT 1444
+ K+ L L FQ D++ +W+ E L D ++E + K L +
Sbjct: 4312 QHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVL 4371
Query: 1445 AQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLD----RWKALKAQLIDERTKL-GDY 1499
A + + + LI E A EE A+ LQ L+ RW+ + + + +L G
Sbjct: 4372 AHQSTVEAVNKAGNDLI--ESSAGEE-ASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4428
Query: 1500 ANLKQFYRDLEELEEWISE----MLPT----ACDESYKDATNIQRKYLKHQTFAHEVDGR 1551
K F+ ++E+L++W+++ +L + E+ K+ N+ H + +
Sbjct: 4429 RQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV------HMEVCAAFEAK 4482
Query: 1552 SEQVHGVINLGNSLIECSACDGNEEAMKEQ-LEQLKEHWDHLLERTNDKGKKLNEA-SRQ 1609
E ++ G ++ + C + E +Q + LKE W+ + + N++ KL EA +
Sbjct: 4483 EETYKSLMQKGQQML--ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLA 4540
Query: 1610 QRFNTSIRDFEFWLSEAE-TLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNT 1668
F+ S++DF WL++AE TL + L + + +H++ E+ + + + +L+
Sbjct: 4541 MEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDK 4600
Query: 1669 LAEDL-LSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF-QFFQDLDDEE 1726
L S +V I +V R+ V + L +A QF +
Sbjct: 4601 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4660
Query: 1727 SWIEEKLIRVSSQ-DYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAV 1785
W+EE + S+ + D ++ L +HK + L A LK+K ++
Sbjct: 4661 EWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4720
Query: 1786 GQEEIQL--RLAQFVEHWEKLKELAKARGLKLEESLEYL-QFMQNAEEEEAWINE-KNAL 1841
+ ++L L++ + W+ + + R KLEE+L + QF + W+ + L
Sbjct: 4721 ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4780
Query: 1842 AVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEES----QNK 1897
A + +L+ H+A + + + VQ + +++ + S Q +
Sbjct: 4781 AEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQ 4840
Query: 1898 EISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNG 1957
E+S++ E + + S + A Q E EF+ + W+A+ E +L+ +G
Sbjct: 4841 ELSTRWETVCALSISKQTRLEAALRQAE------EFHSVVHALLEWLAEAEQTLRFHGVL 4894
Query: 1958 ADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLK-R 2016
D D L L Q ++ L + T + D +++ H S + + +++ R
Sbjct: 4895 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4954
Query: 2017 WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLN 2076
+E++L + H+Q+L L ++L A W E + + V +
Sbjct: 4955 FEEVLAWAKQHQQRLASALAGLIAKQELLEALL----AWLQWAETTLTDKDKEVIPQEIE 5010
Query: 2077 EIRQLQKDHEDFLASLARAQAD 2098
E++ L +H+ F+ + R Q D
Sbjct: 5011 EVKALIAEHQTFMEEMTRKQPD 5032
Score = 194 bits (493), Expect = 9e-49
Identities = 436/2211 (19%), Positives = 894/2211 (40%), Gaps = 271/2211 (12%)
Query: 56 QVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTR 115
++ K D K +++KV+++T++ + ++ QK + + + R + ++
Sbjct: 2969 EIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQL 3028
Query: 116 EERFTMGHSAH--------EETKAHIEELRH--------LWDLLLELTLEKGDQLLRALK 159
+ ++G A+ + + ++ L+H DL++E + KG + L+
Sbjct: 3029 DIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDV-LLQ 3087
Query: 160 FQQYVQECADILEWIGDK-EAIATSVE-LGEDWERTEVLHKKFEDFQVEL--VAKEGRVV 215
+ QE + + + + +K + T ++ +G + +F +F EL +A GR
Sbjct: 3088 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3147
Query: 216 EVNQYANE---------------------------CAEENHPDLPLIQSKQNEVNAAWER 248
E Q E EE PDL I+ ++ +
Sbjct: 3148 ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK 3207
Query: 249 LRGLALQRQKALSNA--------ANLQRFKRDVTEAIQWIKEKEPV-LTSEDYGKDL--- 296
L A R++ + + L+ F + +A + + + PV + +E + L
Sbjct: 3208 LLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMF 3267
Query: 297 -VASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLT-LSHPSDAPQIQEMKEDLVSSWEH 354
V + +G ++++ + + + AK+ L H D D+ + W+
Sbjct: 3268 KVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD---------DVNARWKT 3318
Query: 355 IRALATSRYEKLQATYWY-HRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQ 413
+ R +LQ + RF + L WM + T + A++ P A +V+ + Q
Sbjct: 3319 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD-TEELVANQKPPS-AEFKVVKAQIQ 3376
Query: 414 QHKHEIDSYDDRFQSADETGQD--LVNANHEASDEVR--EKMEILDNNWTALLELWDERH 469
+ K DDR + + ++ + E +D+V+ +++ +LD+ W ALL + R+
Sbjct: 3377 EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN 3436
Query: 470 RQYEQC-LDFHLFYRDSEQVDSWMSRQEAFLEN-EDLGNSLGSAEALLQKHEDFEEAFTA 527
RQ E + F+ E ++ W++ E L N E +G E + +H+ E+
Sbjct: 3437 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3496
Query: 528 QEEKIITVDKTATKL-IGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQK 586
+ + L + D + +++ D ++EK+ +R LL+++L K
Sbjct: 3497 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3556
Query: 587 LY-EDSDDLKNWINK---KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQK 642
++ ED +L NW+N+ K +DY + L + + +V ++++ + K ++
Sbjct: 3557 IFGEDEVELMNWLNEVHDKLSKLSVQDYST-EGLWKQQSELRVLQEDILLRKQNVDQALL 3615
Query: 643 TGQEMIEGGHYASDNVTT---RLSEVASLWEELLEATKQKGTQLHEANQQLQ-FENNAED 698
G E+++ D V +L + + ++++ + + L +A Q + + E+
Sbjct: 3616 NGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEE 3673
Query: 699 LQRWLEDVEWQVTSEDYG--KGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEI 756
L WL+ VE ++ S + KG Q ++R L + A + +D L ++++ E+
Sbjct: 3674 LCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA-KNNKALLDSLNEVSSALLEL 3732
Query: 757 GHPDSKDIRARQ--ESLVC----RFEALKEPLATRKKKLLD--LLHLQLICRDTEDEEAW 808
RAR+ E +V R+ + + + T+K + +D +L Q + + E +W
Sbjct: 3733 -----VPWRAREGLEKMVAEDNERYRLVSDTI-TQKVEEIDAAILRSQQFDQAADAELSW 3786
Query: 809 IQETEPSATST---YLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHF 865
I ETE S L +D +++ L + I H+ I ++ + G+K++
Sbjct: 3787 ITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDIIDDLVKSGHKIMTA--C 3842
Query: 866 AAEDVASRVKSLNQ---NMESLRARAARRQNDLE-ANVQFQQYLADLHEAETWIREKEPI 921
+ E+ S K L++ N +++ + R LE A Q+ E W+ E + I
Sbjct: 3843 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI 3902
Query: 922 VDNTNYGA-----------DEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQA 970
+ A + L+ +H+ + +N G + L
Sbjct: 3903 ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL------------ 3950
Query: 971 APVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAA--DHQGIVPA 1028
+P EG + +++ +A ++ +V + + +S + K++ + IV
Sbjct: 3951 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4010
Query: 1029 VYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRL--LQRYNEFL 1086
+ E + ++ E N++ E+++ Y +L R EE R +
Sbjct: 4011 LRQPPSISAEVEKIKEQISENK-NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 4069
Query: 1087 LAYEAGDMLEWIQEK---KAENTGVELDDVWELQKKF--------------DEFQKDLN- 1128
+ D + +I E E +L DV EL +KF +F +DL
Sbjct: 4070 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED 4129
Query: 1129 -------------TNEPRLRDINKVADDL---------LFEGLLTPEGAQIRQ---ELNS 1163
E +I+ + ++L L P+ +++ ELNS
Sbjct: 4130 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4189
Query: 1164 RWGSLQRLADEQRQLLGSAHAVEVFHREA-DDTKEQIEKKCQALSAADP-GSDLFSVQAL 1221
W SL + ++ L A V +++ + ++ L++ P G+DL +V+
Sbjct: 4190 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4249
Query: 1222 QRRHEGFERDLVPLGDKVTILGETAERLSESHPDATED--LQRQKMELNEAWEDLQGRTK 1279
+ F+ + ++ L AE L + + ++ +Q MEL W+ L+ R
Sbjct: 4250 IEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERII 4309
Query: 1280 DRKESLNEAQKFYLFLSKARD-LQNWISSIGGMVSSQE-LAEDLTGIEILLERHQEHRAD 1337
+R+ L A A D L W++ G++S Q+ + D IEI L +H + D
Sbjct: 4310 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQND 4369
Query: 1338 MEAEAPTFQALEDFSAELIDS--GHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCL 1395
+ A T +A+ +LI+S G AS ++ KL+ + ++ + E+RK+ LD L
Sbjct: 4370 VLAHQSTVEAVNKAGNDLIESSAGEEAS-NLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4428
Query: 1396 -ELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDK----AITAQEGKI 1450
+ + F G + ++ W+ E L + L L K++ ++ A A+E
Sbjct: 4429 RQAKGFHGEIEDLQQWLTDTERHLLAS--KPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4486
Query: 1451 TDLEHFAESLIAD-EHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLK-QFYRD 1508
L + ++A A+ I + + ++W++++ +L + +TKL + NL +F+
Sbjct: 4487 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4546
Query: 1509 LEELEEWISEMLPTACDESYKDAT--NIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLI 1566
L++ W+++ T S + + +H+ FA+EV+ EQ+ + G L
Sbjct: 4547 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4606
Query: 1567 ECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEA-SRQQRFNTSIRDFEFWLSE 1625
S + +K L ++ W+ +++R ++G+ L++A R ++F+ + WL E
Sbjct: 4607 YFSQKQ-DVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEE 4665
Query: 1626 AETLLAMK-DQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQI 1684
+E L + + A D L +H+ ++ + A+ N L T D
Sbjct: 4666 SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEK-TSLADDN 4724
Query: 1685 VKKKDNVNK---RFLNVQELAAAHHEKLKEAYALF-QFFQDLDDEESW---IEEKLIRVS 1737
+K D +++ ++ + + KL+EA QF L W +E +L
Sbjct: 4725 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL--AE 4782
Query: 1738 SQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQF 1797
Q D+ V NL+ HK + EL ++Q + A +L + + +++++ +
Sbjct: 4783 DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQEL 4842
Query: 1798 VEHWEKLKELAKARGLKLEESLEYL-QFMQNAEEEEAWINE-KNALAVRGDCGDTLAATQ 1855
WE + L+ ++ +LE +L +F W+ E + L G D A +
Sbjct: 4843 STRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALR 4902
Query: 1856 SLLMKHEALENDFAVHETRVQNVCAQGEDIL----------------------NKVLQEE 1893
+L+ +H+ + G+ +L +VL
Sbjct: 4903 TLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWA 4962
Query: 1894 SQNKE-ISSKIEALNEKTPSLAKAIAAWKLQLE---DDYAFQEFNWKADVVEAWIADKET 1949
Q+++ ++S + L K L +A+ AW E D + + + V+A IA+ +T
Sbjct: 4963 KQHQQRLASALAGLIAK-QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQT 5021
Query: 1950 SLKTNGNGADLGDFLTLLAKQDTLD-ASLQSF---------QQERLPEITDLKDKLISAQ 1999
++ D +T K+ D +SLQS ++R P S
Sbjct: 5022 FMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFP----ASSLYPSGS 5077
Query: 2000 HNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAH 2050
Q + R L+ +W+Q+ + R+KL + L + E+L EFA+
Sbjct: 5078 QTQIETKNPRVNLLVSKWQQVWLLALERRRKLND---ALDRLEEL-REFAN 5124
Score = 156 bits (395), Expect = 2e-37
Identities = 445/2411 (18%), Positives = 946/2411 (39%), Gaps = 288/2411 (11%)
Query: 39 KERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTN-----IQGKYQK 93
K+++AE KL LQ + ++ + +W+ +K+N K + P ++ + ++
Sbjct: 2445 KDKIAELNTKLSK---LQKAQEESSAMMQWL-QKMNKTATKWQQTPAPTDTEAVKTQVEQ 2500
Query: 94 HQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEET--KAHIEELRHLWDLLLELTLEKG 151
++S EAE++ + EL+ E E K + E+ W L +LT+++
Sbjct: 2501 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2560
Query: 152 DQLLRALK-FQQYVQECADILEWIGDKEAIATSV-ELGEDWERTEVLHKKFEDFQVELVA 209
+L + Q+ A + +W+ +KE + + + L D ++ + E
Sbjct: 2561 QKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFAT 2620
Query: 210 KEGRVVEVNQYANECAEENHPDLPL---IQSKQNEVNAAWERLRGLALQR----QKALSN 262
++ + ++ D L ++ + V W+ L G R +A+
Sbjct: 2621 RKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK 2680
Query: 263 AANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKE 322
+ Q R +++ + + K + D + + + + +++ + ++K
Sbjct: 2681 STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQ--LETAQKMKQEIQQEKKQIKV 2738
Query: 323 LCAKAEKLTLSHPSD--APQIQEMKEDLVSSWEHIRALATSRYEKLQ-ATYWYHRFSSDF 379
A E L+ + ++ E ++ S++ + A + + LQ A H+F
Sbjct: 2739 AQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2798
Query: 380 DELSGWMNEKTAAINADE-LPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN 438
+ W++ K N + + E L+ H+ + + ++ G++L+
Sbjct: 2799 RDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL- 2857
Query: 439 ANHEASDEVREKMEI--LDNNWTALLELWDERHRQYEQCLDFHLFYRDS-EQVDSWMSRQ 495
+ S++ ++++ + NW + ER + ++ L+ L Y++ E + W+ +
Sbjct: 2858 LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2917
Query: 496 EAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555
+ LE E + K + ++ + ++ TA L+ D E +
Sbjct: 2918 QNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2977
Query: 556 IRDGLLARRDALREKAATRRRLLKESLLLQKLYED-SDDLKNWINKKKKLADDEDYKDIQ 614
L+ + D + E+ +++ L+ K +++ S + K + K+ D D Q
Sbjct: 2978 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQ 3037
Query: 615 NLKSR-VQKQQVFEKELAVNKTQLENIQKTGQEMI--EGGHYASDNVTTRLSEVASLWEE 671
++ + Q +K L K Q++ ++ Q+++ + +V ++ +A
Sbjct: 3038 AYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHST 3097
Query: 672 LLEATKQKGTQLHEANQQL-QFENNAEDLQRWLEDVEWQVTS--------EDYGKGLAEV 722
L + +K + L Q + F+N ++ + + ++ S E K +
Sbjct: 3098 LSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETI 3157
Query: 723 QNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPL 782
+ L+K LE A+ A D + + EE PD I+ E+L + L +
Sbjct: 3158 KAFLKK---LE-ALMASNDNANKTCKMMLATEETS-PDLVGIKRDLEALSKQCNKLLDRA 3212
Query: 783 ATRKKKLLDLL-HLQLICRDTEDEEAWIQETEPSATSTY-LGKDLIASKKLLNRHRVIL- 839
R++++ + L+ ++ +Q+ E S +G + + LN +V
Sbjct: 3213 QAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQK 3272
Query: 840 ENIASHEPRIQEITERGNKMVEEGHFAA---------EDVASRVKSLNQNMESLRAR--- 887
E I + + Q++ G +++ + +DV +R K+LN+ + A+
Sbjct: 3273 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3332
Query: 888 ----AARRQNDLEA------------------NVQFQQYLADLHEAETWIR---EKEPIV 922
R Q+ LE+ + +F+ A + E + R +++ V
Sbjct: 3333 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV 3392
Query: 923 DNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRV 982
+ ++ A A L L+ +AL N+A +Q +EG++ V
Sbjct: 3393 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQ----LEGIS----V 3444
Query: 983 MALYDFQARSPRE---VTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEF 1039
+A + P T++K V + + A H+ + + +
Sbjct: 3445 VAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQA 3504
Query: 1040 PMLPQR-----RREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRY-NEFLLAYEAGD 1093
+ Q RE+ + + + + Y + +++ R L Q N + + +
Sbjct: 3505 VSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVE 3564
Query: 1094 MLEWIQEKKAENTGVELDD-----VWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEG 1148
++ W+ E + + + + D +W+ Q + Q+D+ LR N D L G
Sbjct: 3565 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI-----LLRKQN--VDQALLNG 3617
Query: 1149 L-----LTPEGAQIRQE----LNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQI 1199
L T + I Q+ + +R+ + +L+ + + L A + R T E++
Sbjct: 3618 LELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA---RRLHSTHEEL 3674
Query: 1200 EKKCQALSAADPGSDLFSVQAL--------QRRHEGFERDLVPLGDKVTILGETAERLSE 1251
C L + + Q L Q R + +++ + L E + L E
Sbjct: 3675 ---CTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE 3731
Query: 1252 SHP-DATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQ-NWISSIG 1309
P A E L++ E NE + + + E ++ A +A D + +WI+
Sbjct: 3732 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWIT--- 3788
Query: 1310 GMVSSQELAEDLTGI-EILLERHQEHRADMEAEAPTFQAL--EDFSAELIDSGHH---AS 1363
E + L + +I LE+ Q + T + L +D +L+ SGH A
Sbjct: 3789 ------ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3842
Query: 1364 PEIEKKLQAVKLER-----DDLEKAWEKRKKILDQCLEL-QMFQGNCDQVESWMVAREN- 1416
E EK+ KL++ D + + +R L++ L F +++ W+ ++
Sbjct: 3843 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI 3902
Query: 1417 ------------SLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADE 1464
+LR + E + + + +DK + ++ +L I ++
Sbjct: 3903 ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK-MNKTGPQLLELSPGEGFSIQEK 3961
Query: 1465 HYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTAC 1524
+ A + + ++++ + + + I + T+ D + Q LE + E + + +
Sbjct: 3962 YVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILESLERIVERLRQPPSISA 4019
Query: 1525 D-----ESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMK 1579
+ E + N+ K Q + R E++ + G + + SA +A++
Sbjct: 4020 EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM--IARSGGTDKDISA-----KAVQ 4072
Query: 1580 EQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQA--- 1636
++L+Q+ W+++ ++ KL + +FW ++ +KD
Sbjct: 4073 DKLDQMVFIWENIHTLVEEREAKLLDVMELAE--------KFWCDHMSLIVTIKDTQDFI 4124
Query: 1637 RDLASAG---NLLKKHQ----LLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK- 1688
RDL G +++K+ Q + E+ ++ L + L +L+++ IVKK
Sbjct: 4125 RDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSI 4184
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAY-ALFQFFQDLDDEESWIEEKLIRVSSQD-YGRDLQ 1746
D +N + ++ + +KL+EA A Q+ L W++ +++S G DL+
Sbjct: 4185 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4244
Query: 1747 GVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEE--IQLRLAQFVEHWEKL 1804
V+ +++ K+ + E + ++ + AE L K ++ +Q L + W+ L
Sbjct: 4245 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4304
Query: 1805 KELAKARGLKLEESLEYL-QFMQNAEEEEAWINE-KNALAVRGDCGDTLAATQSLLMKHE 1862
+E R KLE +L L QF +E AW+ + L+ + G A + L KH
Sbjct: 4305 EERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH 4364
Query: 1863 ALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKL 1922
L+ND H++ V+ V G D++ EE+ N + +K+E LN++ ++ + K
Sbjct: 4365 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN--LQNKLEVLNQRWQNVLEKTEQRKQ 4422
Query: 1923 QLEDDYAFQE---FNWKADVVEAWIADKETSLKTNGNGADLGD------------FLTLL 1967
QL D A ++ F+ + + ++ W+ D E L + L +
Sbjct: 4423 QL--DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFE 4480
Query: 1968 AKQDTLDASLQSFQQ--ERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASA 2025
AK++T + +Q QQ R P+ SA+ N I++ L ++WE +
Sbjct: 4481 AKEETYKSLMQKGQQMLARCPK---------SAETN----IDQDINNLKEKWESV----- 4522
Query: 2026 VHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDH 2085
KL E++ L++A +L +EF + NW + E+ L+ + + Q D
Sbjct: 4523 --ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDE 4580
Query: 2086 EDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVL----ERTWKHLSDIIEER 2141
A+ + + ++ELD+ L S + ++ L + W+ + + ER
Sbjct: 4581 HKVFANEVNSHRE--QIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVER 4638
Query: 2142 EQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSL--LKETGTLESQLEAN 2199
+ L ++AR + ++F + S ++W LE LD L + +++QL +
Sbjct: 4639 GRSL--DDAR-----KRAKQFHEAWSKLMEW-LEESEKSLDSELEIANDPDKIKTQLAQH 4690
Query: 2200 KRKQKEIQAMK----------RQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLG 2249
K QK + A R L + L D D L LD S L +WD +
Sbjct: 4691 KEFQKSLGAKHSVYDTTNRTGRSLKEKTSLAD---DNLKLDDMLSE--LRDKWDTICGKS 4745
Query: 2250 LRMQHNLEQQI 2260
+ Q+ LE+ +
Sbjct: 4746 VERQNKLEEAL 4756
Score = 130 bits (326), Expect = 2e-29
Identities = 246/1229 (20%), Positives = 521/1229 (42%), Gaps = 154/1229 (12%)
Query: 22 EEIQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIME---KVNILT 77
E +++ E RY+ + + ++ ++++ + Q F + AD WI E K+ L
Sbjct: 3739 EGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLG 3798
Query: 78 DKSYE-DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEET-KAHIEE 135
D E D T+ Q + QK + E+ ++ +L K+ + T +++ K +++
Sbjct: 3799 DIRLEQDQTSAQLQVQK--TFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK 3856
Query: 136 LRHLWDLLLELTLEKGDQLLRALKF-QQYVQECADILEWIGDKEAIATSVELGEDWERTE 194
+ +D + ++ E+ QL RA Q+ + ++ W+ + ++I + +L E
Sbjct: 3857 VLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS--QLPAPALEYE 3914
Query: 195 VLHKKFEDFQV--ELVAK-EGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRG 251
L ++ E+ + EL+A+ + + ++N+ + E + + IQ K + + +++
Sbjct: 3915 TLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3974
Query: 252 LALQRQKALSNAAN-------------------LQRFKRDVTEAIQWIKEKEPVLTSEDY 292
+R AL A + ++R ++ + + + K KE + +++
Sbjct: 3975 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNV 4034
Query: 293 GKDLVASEGLFHSHKGL-ERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSS 351
D+ + L+ + K E +A K++ AKA +Q+ + +V
Sbjct: 4035 SVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA-------------VQDKLDQMVFI 4081
Query: 352 WEHIRALATSRYEKL-QATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLD 410
WE+I L R KL +F D L + + I E P G + +
Sbjct: 4082 WENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP----GIDPSVV 4137
Query: 411 RHQQH-----KHEIDSYDDRFQSADETGQDLVNANHEASDE-VREKMEILDNNWTALLEL 464
+ QQ + EID + G +L+ A E V++ ++ L++ W +L +
Sbjct: 4138 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4197
Query: 465 WDERHRQYEQCLDFHLFYRDSEQ-VDSWMSRQEAFLEN-EDLGNSLGSAEALLQKHEDFE 522
W +R + E+ + + Y+D Q V W+ L + +G L + + +++ + F+
Sbjct: 4198 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK 4257
Query: 523 EAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARR---DALREKAATRRRLLK 579
Q+ ++ ++ A L+ +S+ ++D L+ + D+L E+ R+ L+
Sbjct: 4258 SEAYQQQIEMERLNHQAELLLKKVTEESDK-HTVQDPLMELKLIWDSLEERIINRQHKLE 4316
Query: 580 ESLLLQKLYEDS-DDLKNWINKKKKLADDEDYK--DIQNLKSRVQKQQVFEKELAVNKTQ 636
+LL ++ + D+L W+ + L ++ D + ++ + K V + ++ +++
Sbjct: 4317 GALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQST 4376
Query: 637 LENIQKTGQEMIEG--GHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FE 693
+E + K G ++IE G AS N+ +L + W+ +LE T+Q+ QL A +Q + F
Sbjct: 4377 VEAVNKAGNDLIESSAGEEAS-NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFH 4435
Query: 694 NNAEDLQRWLEDVEWQVTSEDYGKGLAEV-QNRLRKHGLLESAVAARQDQVDILTDLAAY 752
EDLQ+WL D E + + GL E + +L H + +A A+++ L
Sbjct: 4436 GEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQ 4495
Query: 753 FEEIGHPDSKDIRARQE--SLVCRFEALKEPLATRKKKLLDLLHLQLICRDT-EDEEAWI 809
P S + Q+ +L ++E+++ L RK KL + L+L + ++ +D W+
Sbjct: 4496 MLA-RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWL 4554
Query: 810 QETEPS---ATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERG---------- 856
+ E + A+ L D + + ++ H+V + SH +I E+ + G
Sbjct: 4555 TQAEQTLNVASRPSLILDTVLFQ--IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQ 4612
Query: 857 --------------------NKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE 896
++VE G + +D R K ++ L + L+
Sbjct: 4613 DVVLIKNLLISVQSRWEKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4671
Query: 897 ANVQ-------FQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLN 949
+ ++ + LA E + + K + D TN G LK+ + D
Sbjct: 4672 SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN------RTGRSLKEKTSLADDNL 4725
Query: 950 SFGDSMKALRNQANAC------QQQQAAPVEGVAGE--QRVMALYDFQARSPREVTMKK- 1000
D + LR++ + +Q + +G+ + AL D+ R ++ +
Sbjct: 4726 KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP 4785
Query: 1001 --GDVLTLLSSI-NKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQ 1057
GD+ +++ I N ++ E V A ++R A + L + R++ + +
Sbjct: 4786 VHGDIDLVMNLIDNHKAFQKELGKRTSSVQA--LKRSARE----LIEGSRDDSSWVKVQM 4839
Query: 1058 EQIENQYRSLLDRAEERRRRL---LQRYNEFLLAYEAGDMLEWIQEKKAENT----GVEL 1110
+++ ++ ++ + ++ RL L++ EF A +LEW+ E AE T GV
Sbjct: 4840 QELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA--LLEWLAE--AEQTLRFHGVLP 4895
Query: 1111 DDVWELQKKFDEFQKDLNTNEPRLRDINK 1139
DD L+ D+ ++ + E + ++NK
Sbjct: 4896 DDEDALRTLIDQHKEFMKKLEEKRAELNK 4924
Score = 125 bits (314), Expect = 5e-28
Identities = 431/2270 (18%), Positives = 886/2270 (39%), Gaps = 316/2270 (13%)
Query: 273 VTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTL 332
V + + W+ E + L ++G DL + E +HK + R + +KE AK ++ +
Sbjct: 637 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQM 694
Query: 333 SHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKT-- 390
+ P +++ ++ + L TSR ++ ++ S +EL W+NEK
Sbjct: 695 TAPLKLTYAEKLHR---LESQYAKLLNTSRNQERHLDTLHNFVSRATNELI-WLNEKEEE 750
Query: 391 -AAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVRE 449
A + E T++A + D H + E+D ++ +S E + L+ NH A +
Sbjct: 751 EVAYDWSERNTNIARKK---DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEA 807
Query: 450 KMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENE---DLGN 506
+ W+ +L+L + ++ + F+ D+++ ++ + ++ + D +
Sbjct: 808 YRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS 867
Query: 507 SLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSE-------NIKAI--- 556
S+ E L+Q+ + +E + I + A +I +S+ IKAI
Sbjct: 868 SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDY 927
Query: 557 ---------RDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADD 607
D + ++ R K E+++ + K ++ ++ +
Sbjct: 928 RQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--E 985
Query: 608 EDYKDIQNL--KSRVQKQQVFEKELAVNKTQLENIQKTG----QEMIEGGHYASDNVTTR 661
+ Y+++ L +S + + V +N +++ I+ + + M+ G H
Sbjct: 986 QQYQNVLTLWHESHINMKSVVSWHYLIN--EIDRIRASNVASIKTMLPGEHQQV------ 1037
Query: 662 LSEVASLWEELLEATKQKGTQLHEANQQLQFENNA--EDLQRWLEDVEWQVTSED-YGKG 718
LS + S +E+ LE +++ QL+ E N + Q L+ E + E Y
Sbjct: 1038 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 1097
Query: 719 LAEVQN-RLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEA 777
++EV+N RLR LE+ +D+ ++ + E +S QE L E
Sbjct: 1098 ISEVRNIRLR----LENC----EDR--LIRQIRTPLERDDLHESVFRITEQEKLKKELER 1147
Query: 778 LKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY-LGKDLIASKKLLNRHR 836
LK+ L T K + + + + Y + I K +N
Sbjct: 1148 LKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVN--- 1204
Query: 837 VILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQ---N 893
++L+N + E ++ K+ EE A+ + +++L ++ R+ ++ +
Sbjct: 1205 LVLKNTQAAEALVKLYE---TKLCEEEAVIAD--KNNIENLISTLKQWRSEVDEKRQVFH 1259
Query: 894 DLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAF-------LL 946
LE +Q + ++D E + KE +D + +E A L+++ + L
Sbjct: 1260 ALEDELQKAKAISD----EMFKTYKERDLD---FDWHKEKADQLVERWQNVHVQIDNRLR 1312
Query: 947 DLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTL 1006
DL G S+K R+ + ++ V QR + + Q + + + + L
Sbjct: 1313 DLEGIGKSLKYYRDTYHPLDDW----IQQVETTQR--KIQENQPENSKTLATQLNQQKML 1366
Query: 1007 LSSINKDWWKVE-----AADHQGIVPAVYVRRLAH-------DEFPMLPQRRREEPGNIT 1054
+S I K++ A + V ++ + + + P+ +R + I
Sbjct: 1367 VSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII 1426
Query: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVW 1114
Q + +Y +L+ L+ +Y +F AGD L+ ++E E +E ++
Sbjct: 1427 QEFMDLRTRYTALV--------TLMTQYIKF-----AGDSLKRLEE---EEKSLE-EEKK 1469
Query: 1115 ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADE 1174
E +K E QK ++ L+D K + ++ E ++E S +LQ +
Sbjct: 1470 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE--ALQTI--- 1524
Query: 1175 QRQLLGSAHAVEVFHREADDTKEQI------------EKKCQALSAADPGSDLFSVQALQ 1222
QL + H ++ E ++ ++Q+ E Q + G + +
Sbjct: 1525 --QLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVA 1582
Query: 1223 RRHEGFERDLVPLGDKVTILGETAERLSESHP-----DATEDLQRQKMELNEAWEDLQGR 1277
R + ++ L + D +L +T RL D T +L++ + + E +D+QG
Sbjct: 1583 ERQQEYKEKLQGICD---LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGS 1639
Query: 1278 TKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRAD 1337
+ E + + F ++ +S + Q+L E E L + ++ + +
Sbjct: 1640 AQALAEVVKNTENF------LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE 1693
Query: 1338 MEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLEL 1397
++ T E + + +IE L + D E+A K K++++Q
Sbjct: 1694 LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQ--NG 1751
Query: 1398 QMFQ--------GNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGK 1449
FQ G D+V ++ E + ++ ++L +K + I +Q
Sbjct: 1752 THFQEGDGKSAIGEEDEVNGNLL--ETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQA 1809
Query: 1450 ITDLEHFAESLIADE-HYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYAN-----LK 1503
+ A+ L+ + Y E +LQ+ + K + E K + L+
Sbjct: 1810 VIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELE 1869
Query: 1504 QFYRDLEELEEWI--SEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINL 1561
+F D E E W+ SE + D + K + ++F+ +V + +
Sbjct: 1870 KFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITIS 1929
Query: 1562 GNSLIE----CSACDGNE-------EAMKEQLEQLKEHWDHLLERTNDKGKKLNE-ASRQ 1609
GN ++E CS DG + ++ +L+ + + L + N G L + +
Sbjct: 1930 GNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY 1989
Query: 1610 QRFNTSIRDFEFWLSEAETLLA---MKDQARDLASAGNLLKKHQLLEREMLAREDALKDL 1666
Q + + L E + + A D + L++ + L+ ++ +++ A++ L
Sbjct: 1990 QHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKL 2049
Query: 1667 NTLAEDLLSS-GTF--NVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQD-L 1722
AE LL + G+ + I K D++ R+ ++ + +EKL+ QD L
Sbjct: 2050 KKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGL 2109
Query: 1723 DDEESWIEEKLIRVSSQDYGR---DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL 1779
D+ W+ + S ++ G+ + +Q+++ K+ LE ++ + +I + + +K
Sbjct: 2110 DEMLDWMGN--VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKF 2167
Query: 1780 KD-----KAAVGQEEIQLRLAQFVEHWEKLKE-LAKARGLKLEESLEYLQFMQNAEEEEA 1833
+ A+ Q +++ A+F E K KE LAK LK + L F +E+ +
Sbjct: 2168 METTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL----FENLSEKLQT 2223
Query: 1834 WINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEE 1893
++ K D S M+ ++F H+ ++ + + ++I + L +
Sbjct: 2224 FLETKTQALTEVDVPGKDVTELSQYMQEST--SEFLEHKKHLEVLHSLLKEISSHGLPSD 2281
Query: 1894 -----SQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKE 1948
+ +S K + + + +A+ + + QL+ AFQ +++WI KE
Sbjct: 2282 KALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLD---AFQVL---VKSLKSWI--KE 2333
Query: 1949 TSLKT-----NGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKD------KLIS 1997
T+ K + DLG L +DT LQ + PEI + + LIS
Sbjct: 2334 TTKKVPIVQPSFGAEDLGKSL-----EDT--KKLQEKWSLKTPEIQKVNNSGISLCNLIS 2386
Query: 1998 AQHNQSKAI-------------------EERYA--ALLKRWEQLLEAS-------AVHRQ 2029
A +KAI EE +A L + + + S + +
Sbjct: 2387 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2446
Query: 2030 KLLE---KQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHE 2086
K+ E K LQKA++ ++SA+ W +KM + ++ + + ++ E
Sbjct: 2447 KIAELNTKLSKLQKAQE-------ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVE 2499
Query: 2087 DFLASLARAQADFKCLLELDQQIKAL-----GVPSSPYTWLTVEVLERTWKHLSDIIEER 2141
+ A + + + EL ++ L P +P + ++ W+ L+ + +R
Sbjct: 2500 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2559
Query: 2142 EQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYF-LDGSLLKETGTLESQLEANK 2200
+Q+L+ E + + F+ + + QW++E + G L + L +Q + +
Sbjct: 2560 QQKLE-ESSNNLTQFQTVE------AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2612
Query: 2201 RKQKEIQAMKRQLTKIVDLGDNL-----EDALILDI-KYSTIGLAQQWDQLY-QLGLRMQ 2253
+E K Q ++ G + ED + I K + Q+WD L QL R
Sbjct: 2613 ILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCD 2672
Query: 2254 HNLEQQIQAKDIKGVS-EETLKEFSTIYKHFDENLTGRL---THKEFRSCLRGLNYYLPM 2309
++Q I +K + L+ S D L+ L TH + + + L M
Sbjct: 2673 W-IDQAI----VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN--QQLETAQKM 2725
Query: 2310 VEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENI-KSSDEIE 2358
+E + E K K A+ V E+Y + ++ E I KS ++E
Sbjct: 2726 KQEIQQEKKQIKVAQALCEDLSALVK-EEYLKAELSRQLEGILKSFKDVE 2774
Score = 124 bits (312), Expect = 9e-28
Identities = 433/2368 (18%), Positives = 888/2368 (37%), Gaps = 379/2368 (16%)
Query: 6 KETVVESSGPKVLETAEEIQERRQEV---LTRYQSFK----ERVAERGQKLEDSYHLQVF 58
K ++SS +++ +++ R + +T+Y F +R+ E + LE+ V
Sbjct: 1414 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVE 1473
Query: 59 KRDADDLGKWIMEKVNILTD--KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKT-- 114
K A +L KW+ L D K+ + P + K + E+ TK +SE +T
Sbjct: 1474 K--AKELQKWVSNISKTLKDAEKAGKPP------FSKQKISSEEISTKKEQLSEALQTIQ 1525
Query: 115 ---REERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADIL 171
+ M E + ++ L+ ++LL +LK Q Q D+
Sbjct: 1526 LFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS----------ESLKQLQESQTSGDVK 1575
Query: 172 EWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPD 231
+++ +A ER + +K + L E R++ + + +
Sbjct: 1576 V---EEKIVA---------ERQQEYKEKLQGICDLLTQTENRLIGHQEAF--MIGDGTVE 1621
Query: 232 LPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSED 291
L QSKQ E+ + ++G A + + N N ++KE L+ ED
Sbjct: 1622 LKKYQSKQEELQ---KDMQGSAQALAEVVKNTEN-------------FLKENGEKLSQED 1665
Query: 292 YGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSS 351
A++ K+ E K E+L L ++ ++
Sbjct: 1666 K---------------------ALIEQKLNEAKIKCEQLNLKAEQSKKELDKV------- 1697
Query: 352 WEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411
+ EK+ A + + L W++ N D+ ++ AG
Sbjct: 1698 ---VTTAIKEETEKVAAVKQLEESKTKIENLLDWLS------NVDK-DSERAG------- 1740
Query: 412 HQQHKHEIDSYDDRFQSADETG----QDLVNANHEASDEVREKMEILDNNWTALLELWDE 467
+HK I+ FQ D +D VN N +D + +N L + + +
Sbjct: 1741 -TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN----LNQQYQK 1795
Query: 468 RHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTA 527
Q+E+ + H Q + + SA+ LL+K + +
Sbjct: 1796 VKAQHEKIISQH---------------QAVIIATQ-------SAQVLLEKQGQY---LSP 1830
Query: 528 QEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKL 587
+E++ + + K+ HY++ ++ EK L+E L +K
Sbjct: 1831 EEKEKLQKNMKELKV----HYETALAES-------------EKKMKLTHSLQEEL--EKF 1871
Query: 588 YEDSDDLKNWINKKKKLADDEDY--KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQ 645
D + ++W+ + ++ ++ + DI L +++++Q+ F +++ +K L I +G
Sbjct: 1872 DADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGN 1931
Query: 646 EMIEGGHYASDN-------------VTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ- 691
++E S V +L + L G L + + Q
Sbjct: 1932 RVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQH 1991
Query: 692 FENNAEDLQRWLEDVEWQVT---SEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTD 748
+E+ + L L+ E + SE +Q +L + L+ ++++Q V+ L
Sbjct: 1992 YEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKK 2051
Query: 749 LAAYFEEIGH---PDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDE 805
A + P DI+ + +V R+E L + + R +KL L L +D DE
Sbjct: 2052 TAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2111
Query: 806 EA-WIQETEPSATST-YLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEG 863
W+ E S + + A + +++++ ++ ++IA + I + E+ K +E
Sbjct: 2112 MLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETT 2171
Query: 864 HFAAEDVASRVKSLNQNMESLRARAAR----------RQNDLEANVQFQQYLADLHEAET 913
S SL M+ L AR + + +L+ V+ + L++ + +T
Sbjct: 2172 D------PSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE--KLQT 2223
Query: 914 WIREKEPIVDNTNY-GADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQ--ANACQQQQA 970
++ K + + G D +++ + L+ + + +L + ++ +A
Sbjct: 2224 FLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA 2283
Query: 971 APVEGVAGEQRVMALYDFQARSPREVT---MKKGDVLTLLSSINKDWWKVEAADHQGIVP 1027
+E + + + +E ++ D +L K W K VP
Sbjct: 2284 LVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKK----VP 2339
Query: 1028 AVYVRRLAHDEFPMLPQRRR--EEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEF 1085
V A D L ++ E+ T +++ N SL + + +
Sbjct: 2340 IVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA-----VTTPAKA 2394
Query: 1086 LLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLL 1145
+ A ++G + E T ++ W K L + + + DI+ +DL
Sbjct: 2395 IAAVKSGGAV-----LNGEGTATNTEEFWA--------NKGLTSIKKDMTDISHGYEDL- 2440
Query: 1146 FEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQA 1205
GLL + ELN++ LQ+ +E ++ +++ K
Sbjct: 2441 --GLLLKDKIA---ELNTKLSKLQKAQEESSAMM--------------QWLQKMNKTATK 2481
Query: 1206 LSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKM 1265
+D +V+ +++ FE +L +KV L + L E +PD E + ++M
Sbjct: 2482 WQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQM 2541
Query: 1266 --ELNEAWEDLQGRTKDRKESLNE-AQKFYLFLSKARDLQNW-------ISSIGGM-VSS 1314
E++ W++L T DR++ L E + F + L+ W +S +G + +
Sbjct: 2542 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP 2601
Query: 1315 QELAEDLTGIEILLERHQEHRADMEAEAPTFQAL-----EDFSAELIDSGHHASPEIEKK 1369
L ++ILL+ + E Q + ED S I ++++
Sbjct: 2602 NMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGI---------VKEQ 2652
Query: 1370 LQAVKLERDDLEKAWEKRKKILDQCL-ELQMFQGNCDQVESWMVARENSLRSDDKSSL-- 1426
L AV + D L R +DQ + + +Q + + +N L S S
Sbjct: 2653 LAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP 2712
Query: 1427 DSLEALMKKRDDLDKAITAQEGKITDLEHFAESL--IADEHYAKEEIATRLQRVLDRWKA 1484
D++ ++ + + I ++ +I + E L + E Y K E++ +L+ +L +K
Sbjct: 2713 DAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKD 2772
Query: 1485 LKAQLIDERTKL-GDYANLKQFYRDLEELEEWISEMLPTACDESYKD-----ATNIQRKY 1538
++ + + L A+ QF + + + W L T +E K ++
Sbjct: 2773 VEQKAENHVQHLQSACASSHQFQQMSRDFQAW----LDTKKEEQNKSHPISAKLDVLESL 2828
Query: 1539 LK-HQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE-AMKEQLEQLKEHWDHLLERT 1596
+K H+ F+ + +S I G +L+ G+E+ A++ QL +K +WD ++
Sbjct: 2829 IKDHKDFSKTLTAQSHMYEKTIAEGENLL--LKTQGSEKAALQLQLNTIKTNWDTFNKQV 2886
Query: 1597 NDKGKKLNEA-SRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLERE 1655
++ KL E+ + ++ + W+ + + L D A N + K + L++E
Sbjct: 2887 KERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKE 2946
Query: 1656 MLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYAL 1715
M ++ LN A LLS + + + + ++ ++ V E + L+
Sbjct: 2947 MDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK 3006
Query: 1716 FQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775
F+ FQ++ E + +L Q D G Q K+ + A+++ +D+
Sbjct: 3007 FKEFQEVSKES---KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDL 3063
Query: 1776 AEKLKDKAAV------GQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829
A++L V G ++ L++ + L + + LE L+ + QN
Sbjct: 3064 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3123
Query: 1830 EE-----EAWINEKNALAVRGDCGDTL----AATQSLLMKHEAL--ENDFAVHETRVQNV 1878
E + +E +++A G +TL ++ L K EAL ND A ++
Sbjct: 3124 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM-- 3181
Query: 1879 CAQGEDILNKVLQEESQNKEISSK--IEALNEKTPSLAKAIAAWKLQLEDDY-AFQEFNW 1935
+ EE+ + K +EAL+++ L A + Q+E +EF
Sbjct: 3182 ----------LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYS 3231
Query: 1936 KADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDK- 1994
K + E ++ G + + +T++ L F+ + EI L+ K
Sbjct: 3232 KLKEFSILLQKAEEHEESQG---------PVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3282
Query: 1995 ---------LI--SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAED 2043
LI +A+ ++ +E + RW+ L +K+ ++ LQ+A
Sbjct: 3283 QDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL-------NKKVAQRAAQLQEALL 3335
Query: 2044 LFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLA-RAQADFKCL 2102
F +L +W EE ++ + ++ + Q + L L ++ + +
Sbjct: 3336 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3395
Query: 2103 LELDQQIKALGVPSSPYTWL-TVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQE 2161
++I P+ L + +L+ W+ L + E R ++L+ + Q+
Sbjct: 3396 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISV-------VAQQ 3448
Query: 2162 FEQNASTFLQWILETRAYFLDGSLL-KETGTLESQLEANKRKQKEIQAMKRQLTKIVDLG 2220
F + +W+ ++ + + LE Q+ +K + +I + L + V +G
Sbjct: 3449 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3508
Query: 2221 DNL------EDALILDIKYSTIGLAQQW 2242
+L ED D+ S + +Q W
Sbjct: 3509 QSLKVLSSREDK---DMVQSKLDFSQVW 3533
Score = 122 bits (306), Expect = 4e-27
Identities = 304/1638 (18%), Positives = 627/1638 (38%), Gaps = 208/1638 (12%)
Query: 16 KVLETAEE---IQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIME 71
KVL + E+ +Q + Y +E+ R + L+ + + ++F D +L W+ E
Sbjct: 3512 KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNE 3571
Query: 72 KVNILTDKSYEDPTNIQGKYQKHQSLEA--------EVQTKSRLMSELE---KTREERFT 120
+ L+ S +D + +G +++ L + L++ LE +T +
Sbjct: 3572 VHDKLSKLSVQDYST-EGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL 3630
Query: 121 MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAI 180
+ E KA +++ L + + TLE+ QL R L ++ W+ E
Sbjct: 3631 IIQDKLEAIKARYKDITKLSTDVAK-TLEQALQLARRLHSTH-----EELCTWLDKVEVE 3684
Query: 181 ATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYA-----NECAEENHPDLPL- 234
S E T+VL K E Q ++ KE + N A NE + +P
Sbjct: 3685 LLSYE-------TQVL-KGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWR 3736
Query: 235 ----IQSKQNEVNAAWERLRGLALQRQKALSNAA-NLQRFKRDVTEAIQWIKEKEPVLTS 289
++ E N + + Q+ + + A Q+F + + WI E E L S
Sbjct: 3737 AREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMS 3796
Query: 290 -EDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDL 348
D + + K + D + +L K+ + + Q + K D
Sbjct: 3797 LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK 3856
Query: 349 V-SSWEHIRALATSRYEKLQ-ATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGE 406
V +++ I + + RY +L+ A ++F ++EL W+ E + I+ +LP E
Sbjct: 3857 VLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS--QLPAPALEYE 3914
Query: 407 VLLDRHQQHKHE---IDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLE 463
L + ++H+ I + ++TG L+ + ++EK D ++ + E
Sbjct: 3915 TLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3974
Query: 464 LWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEE 523
+R ++ + + D ++D + E +E S+ + +++ +
Sbjct: 3975 DVKKRAVALDEAISQSTQFHD--KIDQILESLERIVERLRQPPSISAEVEKIKEQISENK 4032
Query: 524 AFTAQEEKII----TVDKTATKLIGDDHYDSENI--KAIRDGLLAR-------RDALREK 570
+ EK+ T+ + ++I ++I KA++D L + E+
Sbjct: 4033 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 4092
Query: 571 AATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQN--LKSRVQKQQVFEK 628
A +LL L +K + D L I + D + I +K + + + +
Sbjct: 4093 EA---KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 4149
Query: 629 ELAVNKTQLENIQKTGQEMIEG-GHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEAN 687
E+ + +L+ + G E+I G V + E+ S W+ L +A K + +L EA
Sbjct: 4150 EIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAM 4209
Query: 688 QQ-LQFENNAEDLQRWLEDVEWQVTS-EDYGKGLAEVQNRLRKHGLLESAVAARQDQVDI 745
Q +Q+++ + + W++ ++ S G L V+ ++ + +S +Q +++
Sbjct: 4210 QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER 4269
Query: 746 LTDLAAYF--EEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLD-LLHLQLICRDT 802
L A + D ++ L +++L+E + R+ KL LL L
Sbjct: 4270 LNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHAL 4329
Query: 803 EDEEAWIQETEPSATSTY-LGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVE 861
++ AW+ TE + +G D A + L +H V+ ++ +H+ ++ + + GN ++E
Sbjct: 4330 DELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIE 4389
Query: 862 -EGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANV-QFQQYLADLHEAETWIREKE 919
A ++ ++++ LNQ +++ + +R+ L+ + Q + + ++ + + W+ + E
Sbjct: 4390 SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTE 4449
Query: 920 -PIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAG 978
++ + G E A L H + ++ K+L + G
Sbjct: 4450 RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQK----------------G 4493
Query: 979 EQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDE 1038
+Q + AR P+ + ++ ++++ + W VE ++ LA +
Sbjct: 4494 QQML-------ARCPKSA---ETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEF 4543
Query: 1039 FPMLPQ-----RRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGD 1093
L + E+ N+ R I + +D + + + + + G
Sbjct: 4544 HNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGT 4603
Query: 1094 MLEWIQEKK----AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGL 1149
L++ +K+ +N + + WE KV L+ G
Sbjct: 4604 HLKYFSQKQDVVLIKNLLISVQSRWE-----------------------KVVQRLVERGR 4640
Query: 1150 LTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAA 1209
+ + ++ + W L +E + L S + A
Sbjct: 4641 SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEI----------------------AN 4678
Query: 1210 DPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKM--EL 1267
DP D Q Q H+ F++ L T L E A ++L+ M EL
Sbjct: 4679 DP--DKIKTQLAQ--HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4734
Query: 1268 NEAWEDLQGRTKDRKESLNEAQKFY-LFLSKARDLQNWISSI-GGMVSSQELAEDLTGIE 1325
+ W+ + G++ +R+ L EA F F + L +W+ + + Q + D+ +
Sbjct: 4735 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4794
Query: 1326 ILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWE 1385
L++ H+ + ++ + QAL+ + ELI+ S VK++ +L WE
Sbjct: 4795 NLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-------SWVKVQMQELSTRWE 4847
Query: 1386 --------KRKKILDQCLELQMFQGNCDQVESWMVARENSLR-----SDDKSSLDSL--- 1429
K+ ++ + + F + W+ E +LR DD+ +L +L
Sbjct: 4848 TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ 4907
Query: 1430 -----EALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKA 1484
+ L +KR +L+KA T + + +S+ +H+ I R + VL K
Sbjct: 4908 HKEFMKKLEEKRAELNKATTMGDTVLAICH--PDSITTIKHWI-TIIRARFEEVLAWAKQ 4964
Query: 1485 LKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESY----KDATNIQRKYLK 1540
+ +L A L LE L W+ T D+ ++ ++ +
Sbjct: 4965 HQQRLASA------LAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE 5018
Query: 1541 HQTFAHEVDGRSEQVHGV 1558
HQTF E+ + V V
Sbjct: 5019 HQTFMEEMTRKQPDVDKV 5036
Score = 105 bits (262), Expect = 5e-22
Identities = 429/2370 (18%), Positives = 878/2370 (37%), Gaps = 423/2370 (17%)
Query: 187 GEDWERTEVLHKKFEDF----QVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNE- 241
GE + L +FEDF Q V + ++ + N C + L + ++ E
Sbjct: 1032 GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEE 1091
Query: 242 --VNAAWERLRGLALQRQKALSNAANLQRF---KRDVTEAIQWIKEKEPVLTSEDYGKDL 296
N +R + L+ + R + D+ E++ I E+E + + KD
Sbjct: 1092 SVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD- 1150
Query: 297 VASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIR 356
+L +++K +E ++A + S P ++ ++ + +
Sbjct: 1151 ---------------DLGTITNKCEEFFSQA-----AASSSVPTLRSELNVVLQNMNQVY 1190
Query: 357 ALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHK 416
+++++ +KL+ + + + L K A + D E L+ +Q +
Sbjct: 1191 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA--VIADKNNIENLISTLKQWR 1248
Query: 417 HEID-------SYDDRFQSADETGQDLVNANHEAS---DEVREKMEILDNNWTALLELWD 466
E+D + +D Q A ++ E D +EK + L W + D
Sbjct: 1249 SEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1308
Query: 467 ERHRQYEQCLDFHLFYRDS-EQVDSWMSRQEAF---LENEDLGNSLGSAEALLQKHEDFE 522
R R E +YRD+ +D W+ + E ++ NS A L Q
Sbjct: 1309 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQ------ 1362
Query: 523 EAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLL------ARRDALREKAATRRR 576
Q+ + ++ +K+ Y + ++D L A D+ ++ RRR
Sbjct: 1363 -----QKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRR 1417
Query: 577 LLKESLLLQKLYED-------------------SDDLKNWINKKKKLADD-----EDYKD 612
+ + L+ + + D D LK ++K L ++ E K+
Sbjct: 1418 MQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKE 1477
Query: 613 IQNLKSRVQK---------------QQVFEKELAVNKTQLEN--------IQKTGQEMIE 649
+Q S + K Q++ +E++ K QL + K G +M +
Sbjct: 1478 LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTD 1537
Query: 650 GGHYASDNVTTRLSEVASLW-----EELLEATKQKGTQLHE---ANQQLQFENNAEDLQR 701
+ L E +L ++L E+ ++ E A +Q +++ + +
Sbjct: 1538 EERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICD 1597
Query: 702 WLEDVEWQVTSED----YGKGLAEVQNRLRKHGLLESAV-AARQDQVDILTDLAAYFEEI 756
L E ++ G G E++ K L+ + + Q +++ + + +E
Sbjct: 1598 LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1657
Query: 757 GHPDSKDIRARQESLVCRFEALKEPL---ATRKKKLLDLLHLQLICRDTEDEEAWIQETE 813
G S++ +A E + + E L A + KK LD + I +TE A +++ E
Sbjct: 1658 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA-VKQLE 1716
Query: 814 PSATSTYLGKDLIA-----SKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAE 868
S T D ++ S++ +H+ ++E +H + G + G+
Sbjct: 1717 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1776
Query: 869 DVASRV----KSLNQNMESLRARAARRQNDLEANV---QFQQYLADLHEAETWIREKEPI 921
DV +V ++LNQ + ++A+ + + +A + Q Q L + EKE +
Sbjct: 1777 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1836
Query: 922 VDN-----TNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGV 976
N +Y + +K + +L F + +Q+ G
Sbjct: 1837 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 1896
Query: 977 AGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQ--GIVPAVYVRRL 1034
+M Q +V KGD+ + S N+ ++ + G V R
Sbjct: 1897 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHRE 1956
Query: 1035 AHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDM 1094
+ R R ++ + + N + L+D+ Q Y + AG
Sbjct: 1957 VQRKLDHATDRFR----SLYSKCNVLGNNLKDLVDK--------YQHYEDASCGLLAGLQ 2004
Query: 1095 LEWIQEKKAENTGVELDDVWELQKKFDE---FQKDLNTNEPRLRDINKVADDLL-FEGLL 1150
K + + +D LQ++ +E Q +++ + + + K A+ LL G L
Sbjct: 2005 ACEATASKHLSEPIAVDPK-NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSL 2063
Query: 1151 TPEGAQIRQELNS---RWGSLQRLADEQRQ----LLGSAHAVEVFHREADDTKEQIEKKC 1203
P I++ L+ R+ L + +E+ + L + +V+ E D +E
Sbjct: 2064 LPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL 2123
Query: 1204 QALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSES-HPDATEDLQR 1262
+ S ++Q + ++ E+D+ + + E ++ E+ P LQ
Sbjct: 2124 KEQGQVPLNST--ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQA 2181
Query: 1263 QKMELNEAWEDLQGRTKDRKESLNEAQ-KFYLFLSKARDLQNWISSIGGMVSSQELAE-D 1320
+ +L+ + + + K+ + E + K LF + + LQ ++ + +Q L E D
Sbjct: 2182 KMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLET-----KTQALTEVD 2236
Query: 1321 LTGIEI--LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIE-KKLQAVKLER 1377
+ G ++ L + QE ++ + L E+ G + + +K + +
Sbjct: 2237 VPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKF 2296
Query: 1378 DDLEKAWEKRKKILDQCLE-LQMFQGNCDQVESWMV--------------------AREN 1416
++E +++K+ + C E L FQ ++SW+ + E+
Sbjct: 2297 KEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLED 2356
Query: 1417 SLRSDDKSSLDSLEALMKKRDDLD------------KAITAQEGKITDLEHFAESLIADE 1464
+ + +K SL + E + KAI A + L + +E
Sbjct: 2357 TKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEE 2416
Query: 1465 HYA-------KEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWIS 1517
+A K+++ D LK ++ + TKL + L++ + + +W+
Sbjct: 2417 FWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL---SKLQKAQEESSAMMQWLQ 2473
Query: 1518 EMLPTACD----ESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDG 1573
+M TA + D ++ + ++++F E+ +V + + L+E +
Sbjct: 2474 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2533
Query: 1574 NEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQ-QRFNTSIRDFEFWLSEAETLLAM 1632
K+ L ++ W L + T D+ +KL E+S +F T + WL E E ++++
Sbjct: 2534 EAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV 2593
Query: 1633 KDQARDLASAGNLL----KKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688
L+ N+L ++ Q+L +E R+ + L + +LS +
Sbjct: 2594 ---LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS----------RPG 2640
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748
++ + R + ++LAA + L D WI++ +++ S Y L+ +
Sbjct: 2641 EDPSLRGIVKEQLAAVTQK-------WDSLTGQLSDRCDWIDQAIVK--STQYQSLLRSL 2691
Query: 1749 QNLLKK-HKRLEGELV--AHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLK 1805
+ L +L L H A+ L+ A+K+K + + QE+ Q+++AQ + E L
Sbjct: 2692 SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE--IQQEKKQIKVAQAL--CEDLS 2747
Query: 1806 ELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALE 1865
L K LK E S + + +L + +E
Sbjct: 2748 ALVKEEYLKAELSRQ---------------------------------LEGILKSFKDVE 2774
Query: 1866 NDFAVHETRVQNVCAQGEDILNKVLQEESQNKE--ISSKIEALNEKTPSLAKAIAAWKLQ 1923
H +Q+ CA Q+ S++ + + +K E N+ P A
Sbjct: 2775 QKAENHVQHLQSACASSHQ-----FQQMSRDFQAWLDTKKEEQNKSHPISA--------- 2820
Query: 1924 LEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQE 1983
K DV+E+ I D + KT + QS E
Sbjct: 2821 ------------KLDVLESLIKDHKDFSKT---------------------LTAQSHMYE 2847
Query: 1984 RLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAED 2043
+ I + ++ L+ Q ++ A++ + + W+ +++ E++ L+++ +
Sbjct: 2848 K--TIAEGENLLLKTQGSEKAALQLQLNTIKTNWD-------TFNKQVKERENKLKESLE 2898
Query: 2044 LFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLL 2103
+++ + L W +K + NL E C+ + E+ +A L Q
Sbjct: 2899 KALKYKEQVETLWPWIDKCQNNLEEIKFCLD-------PAEGENSIAKLKSLQK------ 2945
Query: 2104 ELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFE 2163
E+DQ VE+L T L + E ++ + E ++ +M E
Sbjct: 2946 EMDQHFG------------MVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE-- 2991
Query: 2164 QNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL 2223
L ++ + L+ T + E +K ++++Q K QL D+ D+L
Sbjct: 2992 ---------QLHSKKFCLENM----TQKFKEFQEVSKESKRQLQCAKEQL----DIHDSL 3034
Query: 2224 EDALILDIKYSTIGLAQQWD---QLYQLGLRMQHNLEQQIQAKDIKGVSEETL------K 2274
+ KY T+ QQ +Q+ L + + ++A D KG S+ L +
Sbjct: 3035 GSQAYSN-KYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQ 3093
Query: 2275 EFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHE-PKFEKFLDAVDPGRKGY 2333
E ST+ + DE + T L+G+ ++ + E + +F+ LD++ P +
Sbjct: 3094 EHSTLSQQVDEKCSFLETK------LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3147
Query: 2334 VSL----EDYTAFLIDKESENIKSSDEIEN 2359
+L E AFL K+ E + +S++ N
Sbjct: 3148 ETLQKQKETIKAFL--KKLEALMASNDNAN 3175
Score = 90.1 bits (222), Expect = 2e-17
Identities = 319/1812 (17%), Positives = 680/1812 (37%), Gaps = 242/1812 (13%)
Query: 697 EDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAV--------AARQDQVDILTD 748
+DL W+++++ Q+ ++G L V++ L H + A+ A+ ++ +
Sbjct: 638 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP 697
Query: 749 LAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAW 808
L + E H R ES + + +++ LD LH + R T +E W
Sbjct: 698 LKLTYAEKLH--------RLESQYAKL----LNTSRNQERHLDTLH-NFVSRAT-NELIW 743
Query: 809 IQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAE 868
+ E E + + + + H ++ + E I+ + E +++ E H A
Sbjct: 744 LNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 803
Query: 869 DVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYG 928
+ + ++ + + ++ N + ++ D EA ++R + + Y
Sbjct: 804 TIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR-KYS 862
Query: 929 ADEEAAGALLK--------------KHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVE 974
D ++ L+ ++++ + +L ++ L+ + + C + + P++
Sbjct: 863 CDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIK 922
Query: 975 GVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKV-EAADHQGIVPAVYVRR 1033
+ +++ E+T+ K D L ++ ++ WKV ++ +VP+V
Sbjct: 923 AICDYRQI------------EITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVC--- 967
Query: 1034 LAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGD 1093
F + P + E ++ R IE QY+++L E + + L E
Sbjct: 968 -----FTVPPPNK--EAVDLANR---IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDR 1017
Query: 1094 M-LEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTP 1152
+ + K G + LQ +F++F +D ++ +F G
Sbjct: 1018 IRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQ-------------VFSG---S 1061
Query: 1153 EGAQIRQELNSRWGSLQRL-----ADEQRQLLGSAHAVEV--FHREADDTKEQIEKKCQA 1205
+ Q+ +E+N Q L +EQ + + + + EV ++ ++++ ++ +
Sbjct: 1062 DITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 1121
Query: 1206 -LSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQK 1264
L D +F + ++ + ER LG TI + E S++ A+ + +
Sbjct: 1122 PLERDDLHESVFRITEQEKLKKELERLKDDLG---TITNKCEEFFSQA--AASSSVPTLR 1176
Query: 1265 MELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQE-LAEDLTG 1323
ELN +++ +++ + L L + + + + +E + D
Sbjct: 1177 SELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNN 1236
Query: 1324 IEILLERHQEHRADMEAEAPTFQALED---FSAELIDSGHHASPEIEKKLQAVKLERDDL 1380
IE L+ ++ R++++ + F ALED + + D E + K + D L
Sbjct: 1237 IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 1296
Query: 1381 EKAWEKRKKILDQCL--------ELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEAL 1432
+ W+ +D L L+ ++ ++ W+ E + R ++ ++ + L
Sbjct: 1297 VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTL 1356
Query: 1433 ---MKKRDDLDKAITAQEGKITDLEHFAESLIAD-EHYAKEEIATRLQRVLDRWKALKAQ 1488
+ ++ L I ++ K+ + + +AE A + Y + + R + +K +
Sbjct: 1357 ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR 1416
Query: 1489 LIDERTKL--GDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAH 1546
+ L ++ +L+ Y L L + + ++ +++ + +H A
Sbjct: 1417 RMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAK 1476
Query: 1547 E----VDGRSEQVHGVINLGNSLIECSACDGNE-EAMKEQLEQLKEHWDHLLERTNDKGK 1601
E V S+ + G E KEQL + + L + DK
Sbjct: 1477 ELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMT 1536
Query: 1602 KLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLARED 1661
+++ T + SE+ L + D+ ++ + Q +E L
Sbjct: 1537 DEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKL---Q 1593
Query: 1662 ALKDLNTLAED---------LLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEA 1712
+ DL T E+ ++ GT + + K++ + K ++Q A A E +K
Sbjct: 1594 GICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQK---DMQGSAQALAEVVK-- 1648
Query: 1713 YALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNV 1772
+ E++++E ++S +D Q + K ++L + + + V
Sbjct: 1649 -----------NTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKV 1697
Query: 1773 LDMA--EKLKDKAAVGQ-EEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829
+ A E+ + AAV Q EE + ++ ++ + + ++ G K ++ +E
Sbjct: 1698 VTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEG 1757
Query: 1830 EEEAWINEKNAL-------AVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQG 1882
+ ++ I E++ + V G G T K +A +++ + + + + Q
Sbjct: 1758 DGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA-QHEKIISQHQAVIIATQS 1816
Query: 1883 EDIL----NKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKAD 1938
+L + L E + K + E +LA++ KL ++F+
Sbjct: 1817 AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYT 1876
Query: 1939 VVEAWIADKETSLKTNGNGA-DLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLIS 1997
E W+ E L+ GA D+ +T L +Q +SF ++ + DL+ IS
Sbjct: 1877 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQ-------KSFSEDVISHKGDLRYITIS 1929
Query: 1998 AQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNN 2057
+ E + KR ++ SA HR E Q L A D F K + L N
Sbjct: 1930 GNR-----VLEAAKSCSKRDGGKVDTSATHR----EVQRKLDHATDRFRSLYSKCNVLGN 1980
Query: 2058 ------------------------WCE-KMEENLSEPVHCVSLNEIRQLQ--KDHEDFLA 2090
CE ++LSEP+ N RQL+ K + ++
Sbjct: 1981 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQIS 2040
Query: 2091 SLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEA 2150
S A K E+ + +P+ T++ + ++ LS + ER ++LQ
Sbjct: 2041 SQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLT 2100
Query: 2151 RQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEAN-KRKQKEIQAM 2209
R + + E + E L+ + L++ + LE + +Q I AM
Sbjct: 2101 RSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAM 2160
Query: 2210 KRQLTKIVDLGDNLEDALI------LDIKYSTIG------------LAQQWDQLYQLGLR 2251
++ K ++ D + + L ++S L + + L +
Sbjct: 2161 NEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEK 2220
Query: 2252 MQHNLEQQIQA---KDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLP 2308
+Q LE + QA D+ G K+ + + ++ E+ + L HK+ L L
Sbjct: 2221 LQTFLETKTQALTEVDVPG------KDVTELSQYMQESTSEFLEHKKHLEVLHSL----- 2269
Query: 2309 MVEEDEHEPKFEK--FLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALAE 2366
+ E H +K L+ + K + +ED I ++ E + S E +AFQ L +
Sbjct: 2270 LKEISSHGLPSDKALVLEKTNNLSKKFKEMED----TIKEKKEAVTSCQEQLDAFQVLVK 2325
Query: 2367 GKSYITKEDMKQ 2378
KE K+
Sbjct: 2326 SLKSWIKETTKK 2337
Score = 69.7 bits (169), Expect = 3e-11
Identities = 423/2395 (17%), Positives = 896/2395 (37%), Gaps = 430/2395 (17%)
Query: 68 WIMEKVN--ILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSA 125
W+ EK + D S E TNI K H L E+ K + +++ E+ H A
Sbjct: 743 WLNEKEEEEVAYDWS-ERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPA 801
Query: 126 HEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGD-KEA----- 179
+A+ ++ W +L+L +Q+++E E+ D KEA
Sbjct: 802 RLTIEAYRAAMQTQWSWILQL----------CQCVEQHIKENTAYFEFFNDAKEATDYLR 851
Query: 180 -IATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSK 238
+ +++ +R+ +HK + Q + KE E+ QY + A +IQ K
Sbjct: 852 NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKE----ELLQYKSTIANLMGKAKTIIQLK 907
Query: 239 QNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVA 298
+ + + KA+ + ++ I K+ E VL +
Sbjct: 908 PRNSDCPLKTSIPI-----KAICDYRQIE---------ITIYKDDECVLAN--------- 944
Query: 299 SEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRAL 358
+SH+ + ++ ++ A + + P + ++ + ++++ L
Sbjct: 945 -----NSHRAKWKVISPTGNE-----AMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL 994
Query: 359 ATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHE 418
+ +++ +H ++ D + A N + T + G +H+
Sbjct: 995 WHESHINMKSVVSWHYLINEIDRI--------RASNVASIKTMLPG---------EHQQV 1037
Query: 419 IDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDF 478
+ + RF+ E Q+ + ++ +++ + + LL+ ER Q E +
Sbjct: 1038 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKS-AEREEQEESVYNL 1096
Query: 479 HLF------YRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKI 532
++ R D + + LE +DL S+ + + E ++ ++ +
Sbjct: 1097 YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESV----FRITEQEKLKKELERLKDDL 1152
Query: 533 ITVDKTATKLIGDDHYDSE--NIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYED 590
T+ + S +++ + +L + + ++T LK L+ K +
Sbjct: 1153 GTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA 1212
Query: 591 SDDLKNWINKKKKLADDE----DYKDIQNLKSRV--------QKQQVF---EKELAVNKT 635
++ L + KL ++E D +I+NL S + +K+QVF E EL K
Sbjct: 1213 AEALVKLY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKA 1270
Query: 636 QLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FEN 694
+ + KT +E D + ++ W+ + + L + L+ + +
Sbjct: 1271 ISDEMFKTYKER----DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRD 1326
Query: 695 NAEDLQRWLEDVE--WQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAY 752
L W++ VE + E+ + + +L + +L S + +Q ++D A
Sbjct: 1327 TYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ 1386
Query: 753 FEEI----------------GHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQ 796
+ S R R +S L TR L+ L+
Sbjct: 1387 YSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQY 1446
Query: 797 LICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERG 856
+ + D ++E E S K+ + + + + + +++ +++ + G
Sbjct: 1447 I--KFAGDSLKRLEEEEKSLEE--------EKKEHVEKAKELQKWVSNISKTLKDAEKAG 1496
Query: 857 NKMVEEGHFAAEDVASRVKSLNQNMESLRARAAR--------RQNDLEA---------NV 899
+ ++E+++++ + L++ +++++ A+ +N+LE N+
Sbjct: 1497 KPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNL 1556
Query: 900 QFQQYLADLHEAETW--IREKEPIVDNTNYGADEEAAG----------ALLKKHEAFLLD 947
F + L L E++T ++ +E IV E+ G L+ EAF++
Sbjct: 1557 LFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI- 1615
Query: 948 LNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLL 1007
GD L+ Q +Q + + G + +A EV + L
Sbjct: 1616 ----GDGTVELKKY----QSKQEELQKDMQGSAQALA----------EVVKNTENFL--- 1654
Query: 1008 SSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSL 1067
++ K+ D I + ++ ++ + ++ ++E + + E + +
Sbjct: 1655 ---KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA 1711
Query: 1068 LDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQ--EKKAENTGVELDDVWELQKKFDEFQK 1125
+ + EE + ++ ++L+W+ +K +E G + V +++ FQ+
Sbjct: 1712 VKQLEESKTKI-------------ENLLDWLSNVDKDSERAGTKHKQV--IEQNGTHFQE 1756
Query: 1126 DLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAV 1185
+ + + ++V +LL E + + ++ LN ++ Q++ + +++ AV
Sbjct: 1757 --GDGKSAIGEEDEVNGNLL-ETDVDGQVGTTQENLNQQY---QKVKAQHEKIISQHQAV 1810
Query: 1186 EVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGET 1245
+ + A + +EK+ Q LS + +++ L+ +E L K+ +
Sbjct: 1811 IIATQSA---QVLLEKQGQYLSPEEKEKLQKNMKELKVH---YETALAESEKKMKLTHSL 1864
Query: 1246 AERLSESHPDATED---LQRQKMELNE---AWEDLQG------RTKDRKESL--NEAQKF 1291
E L + D TE LQ+ + EL +D+ G R K E + ++
Sbjct: 1865 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1924
Query: 1292 YLFLSKARDLQ---NWISSIGGMVSSQELAEDLTGIEILLERHQEHRAD-MEAEAPTFQA 1347
Y+ +S R L+ + GG V D + ++R +H D +
Sbjct: 1925 YITISGNRVLEAAKSCSKRDGGKV-------DTSATHREVQRKLDHATDRFRSLYSKCNV 1977
Query: 1348 LEDFSAELIDSGHH---ASPEIEKKLQAVK--LERDDLEKAWEKRKKILDQCLELQMFQG 1402
L + +L+D H AS + LQA + + E K + Q E + QG
Sbjct: 1978 LGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQG 2037
Query: 1403 NCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIA 1462
Q+ S VA E L+ + LD+ +L+ ++D+ K + G+ DL S
Sbjct: 2038 ---QISSQQVAVE-KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDL-----SKSV 2088
Query: 1463 DEHYAKEEIA-TRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLP 1521
+E K +I TR V D L+E+ +W+ +
Sbjct: 2089 NERNEKLQITLTRSLSVQD---------------------------GLDEMLDWMGNVES 2121
Query: 1522 TACDESY--KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMK 1579
+ ++ ++T +Q K+ ++ GR ++ AM
Sbjct: 2122 SLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSIN--------------------AMN 2161
Query: 1580 EQLEQLKEHWD-----HLLERTNDKGKKLNEAS--------RQQRFNTSIRDFEFWLSEA 1626
E++++ E D L + D + +EAS + + T + FE +
Sbjct: 2162 EKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKL 2221
Query: 1627 ETLLAMKDQA--------RDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGT 1678
+T L K QA +D+ +++ E L + L+ L++L +++ S G
Sbjct: 2222 QTFLETKTQALTEVDVPGKDVTELSQYMQES---TSEFLEHKKHLEVLHSLLKEISSHGL 2278
Query: 1679 FNVDQIV-KKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDL-DDEESWIEEKLIRV 1736
+ +V +K +N++K+F +++ E + FQ L +SWI+E +V
Sbjct: 2279 PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV 2338
Query: 1737 SSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL-----------KDKAAV 1785
+ + L+ K+L+ + P IQ V + L K AAV
Sbjct: 2339 PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAV 2398
Query: 1786 -----------------------GQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYL 1822
G I+ + +E L L K + +L L L
Sbjct: 2399 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL 2458
Query: 1823 QFMQNAEEEEA----WINEKNALAVRGDCGDTLAATQSLLMKHEALEN-DFAVHETRVQN 1877
Q A+EE + W+ + N A + T A T + +K + +N F + N
Sbjct: 2459 ---QKAQEESSAMMQWLQKMNKTATKWQ--QTPAPTDTEAVKTQVEQNKSFEAELKQNVN 2513
Query: 1878 VCAQGEDILNKVLQEESQN----------KEISSKIEALNEKTPSLAKAIAAWKLQLEDD 1927
+ +D L ++L+E EI SK + LN+ T + + E
Sbjct: 2514 KVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE------ESS 2567
Query: 1928 YAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSF--QQERL 1985
+F ++ W+ +KE + G + + L +Q + LQ F ++ +
Sbjct: 2568 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQ--VQILLQEFATRKPQY 2625
Query: 1986 PEITDLKDKLISAQHNQSK---AIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE 2042
++T ++S ++E+ AA+ ++W+ L + + + + + +
Sbjct: 2626 EQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQ 2685
Query: 2043 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLN-EIRQLQKDHEDFLASLARAQADFKC 2101
L + K S L+N K+ +L+ H ++N ++ QK ++ + + + K
Sbjct: 2686 SLLRSLSDKLSDLDN---KLSSSLAVSTHPDAMNQQLETAQKMKQE----IQQEKKQIKV 2738
Query: 2102 LLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQE 2161
L + + AL L+ + LE K D+ ++ E +Q ++ + +
Sbjct: 2739 AQALCEDLSALVKEEYLKAELSRQ-LEGILKSFKDVEQKAENHVQHLQSACASS----HQ 2793
Query: 2162 FEQNASTFLQWILETRAYFLDGS--LLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDL 2219
F+Q + F W L+T+ + S + + LES ++ +K K + A K +
Sbjct: 2794 FQQMSRDFQAW-LDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE 2852
Query: 2220 GDNL------EDALILDIKYSTIGLAQQWD----QLYQLGLRMQHNLEQQIQAKD 2264
G+NL + L ++ +TI WD Q+ + +++ +LE+ ++ K+
Sbjct: 2853 GENLLLKTQGSEKAALQLQLNTI--KTNWDTFNKQVKERENKLKESLEKALKYKE 2905
Score = 41.2 bits (95), Expect = 0.012
Identities = 42/210 (20%), Positives = 92/210 (43%), Gaps = 23/210 (10%)
Query: 574 RRRLLKESLLLQKLYEDS------DDLKNWINKKKKLADDEDY-KDIQNLKSRVQKQQ-- 624
R+ LLK SLL Q L E+ DL NW+++ + D ++ D+ +++S ++ +
Sbjct: 614 RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNV 673
Query: 625 ---VFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGT 681
+ E E ++ + ++ IQ T + YA +L + S + +LL ++ +
Sbjct: 674 HRAIEEFESSLKEAKISEIQMTAPLKLT---YAE-----KLHRLESQYAKLLNTSRNQER 725
Query: 682 QLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQD 741
L + F + A + WL + E + + D+ + + + H L + +++
Sbjct: 726 HLDTLH---NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 782
Query: 742 QVDILTDLAAYFEEIGHPDSKDIRARQESL 771
+ + ++A HP I A + ++
Sbjct: 783 NIKSVQEIAEQLLLENHPARLTIEAYRAAM 812
Score = 40.8 bits (94), Expect = 0.016
Identities = 60/342 (17%), Positives = 134/342 (39%), Gaps = 53/342 (15%)
Query: 1707 EKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHE 1766
+ L E +F QDL +W++E +++ ++G DL V++ L+ HK + + E
Sbjct: 625 QNLTEEEINMKFVQDL---LNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFE 681
Query: 1767 PAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKL------EESLE 1820
+++ K+ EIQ+ + + EKL L L E L+
Sbjct: 682 SSLKEA-----KI--------SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLD 728
Query: 1821 YL-QFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVC 1879
L F+ A E W+NEK + E + D++ T +
Sbjct: 729 TLHNFVSRATNELIWLNEK---------------------EEEEVAYDWSERNTNIARKK 767
Query: 1880 AQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADV 1939
+++ ++ Q+E K + E L + I A++ ++ +++
Sbjct: 768 DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSW--ILQLCQC 825
Query: 1940 VEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQ 1999
VE I + + + + D+L ++ DA + + +R I L+D + +
Sbjct: 826 VEQHIKENTAYFEFFNDAKEATDYL-----RNLKDAIQRKYSCDRSSSIHKLEDLVQESM 880
Query: 2000 HNQSKAIEER--YAALLKRWEQLLEASAVHRQKLLEKQLPLQ 2039
+ + ++ + A L+ + + +++ + L+ +P++
Sbjct: 881 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIK 922
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 214 bits (546), Expect = 6e-55
Identities = 443/2242 (19%), Positives = 900/2242 (40%), Gaps = 244/2242 (10%)
Query: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQV-FKRDADDLGKWIMEKVNILTD-KSY 81
+Q + + T + +F ++V ER KL++S + +K + L WI + N L + K
Sbjct: 2879 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2938
Query: 82 EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHE----ETKAHIE--- 134
DP + K +SL+ E+ ++ L T ++ E E K+ I+
Sbjct: 2939 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2998
Query: 135 ---ELRHLWDLLLELTLEKGDQLLRALKFQQYVQECA----DILEWIGDK---------- 177
E H LE +K + K + +CA DI + +G +
Sbjct: 2999 MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML 3058
Query: 178 -------EAIATSVELGEDWERTEVLH----KKFED--FQVELVAKEGRVVEVNQYANEC 224
+A+ V+L + + V+ K D QVE +A+E + +Q +E
Sbjct: 3059 QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL--SQQVDEK 3116
Query: 225 AEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKE 284
L I QN + + + + + + ++ ++K+ E
Sbjct: 3117 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLE 3176
Query: 285 PVLTSEDYG----KDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQ 340
++ S D K ++A+E G++R+L +S + +L +A+
Sbjct: 3177 ALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR---------- 3226
Query: 341 IQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPT 400
+E E + E Y KL+ + + + +E G + +T IN
Sbjct: 3227 -EEQVEGTIKRLEEF-------YSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMF 3278
Query: 401 DVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN--ANHEASDEVREKMEILDNNW 458
V K EI+ + Q + GQ L+ A ++ + ++ ++ W
Sbjct: 3279 KVF-----------QKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3327
Query: 459 TALLELWDERHRQYEQCLDFHLFYRDS-EQVDSWMSRQEAFLENEDLGNS-LGSAEALLQ 516
L + +R Q ++ L ++D+ E + SWM E + N+ ++ +A +Q
Sbjct: 3328 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3387
Query: 517 KHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLL--ARRDALREKAATR 574
+ + + ++ + + + K I ++ +K ++ L +R +AL KA TR
Sbjct: 3388 EQKLLQRLLDDRKSTVEVIKREGEK-IATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3446
Query: 575 RRLLKE-SLLLQKLYEDSDDLKNWINK-KKKLADDEDY-KDIQNLKSRVQKQQVFEKELA 631
R L+ S++ Q+ +E + L W+ +K+L + E L+ ++ + + E ++
Sbjct: 3447 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3506
Query: 632 VNKTQLENIQKTGQEM-IEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEA--NQ 688
+ L GQ + + D V ++L + E+ E + + L +A N
Sbjct: 3507 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3566
Query: 689 QLQFENNAEDLQRWLEDVEWQVTS---EDYG-KGLAEVQNRLRKHGLLESAVAARQDQVD 744
++ E+ E L WL +V +++ +DY +GL + Q+ LR +L+ + R+ VD
Sbjct: 3567 KIFGEDEVE-LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR---VLQEDILLRKQNVD 3622
Query: 745 --ILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT 802
+L L + G + I+ + E++ R++ + + K L L L T
Sbjct: 3623 QALLNGLELLKQTTGD-EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHST 3681
Query: 803 EDEEA-WIQETEPSATS--TYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKM 859
+E W+ + E S T + K AS+ + R + + + +++ + + E + +
Sbjct: 3682 HEELCTWLDKVEVELLSYETQVLKGEEASQAQM-RPKELKKEAKNNKALLDSLNEVSSAL 3740
Query: 860 VEEGHFAA-EDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAE-TWIRE 917
+E + A E + V N+ + ++ +++A + Q +AE +WI E
Sbjct: 3741 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITE 3800
Query: 918 KEP-IVDNTNYGADEEAAGALLKKHEAFLLDL----NSFGDSMKALRNQANACQQQQAAP 972
E ++ + +++ A L+ + F +++ + D +K+ AC +++
Sbjct: 3801 TEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQS 3860
Query: 973 VEGVAGEQRVMALYDF--QARSPREVTMKKGDVLTLLSSINKDWWKVEA-----ADHQGI 1025
++ +V+ YD Q S R + +++ L +N+ W E + Q I
Sbjct: 3861 MKKKL--DKVLKNYDTICQINSERYLQLERAQSL-----VNQFWETYEELWPWLTETQSI 3913
Query: 1026 VPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRS---LLDRAEERRRRLLQRY 1082
+ + L ++ + R+ I + + I+ ++ LL+ + + ++Y
Sbjct: 3914 ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKY 3973
Query: 1083 NEFLLAYEAGDMLEWIQEKKAENTGVELDDV----WELQKKFDEFQKDLNTNEPRLRDIN 1138
A D L ++ + V LD+ + K D+ + L RLR
Sbjct: 3974 -------VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPP 4026
Query: 1139 KVADDL--LFEGLLTPEGAQIRQE-LNSRWGSLQRLADEQRQLLG------SAHAVE--- 1186
++ ++ + E + + + E L + +L++ +E G SA AV+
Sbjct: 4027 SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKL 4086
Query: 1187 -------------VFHREAD--DTKEQIEKK-CQALSAA--------------DPGSDLF 1216
V REA D E EK C +S DPG D
Sbjct: 4087 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 4146
Query: 1217 SVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKM-ELNEAWEDLQ 1275
V+ Q E ++ L +++ I+ L + + + + ++ + ELN AW+ L
Sbjct: 4147 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLN 4206
Query: 1276 GRTKDRKESLNEA-QKFYLFLSKARDLQNWISSIGGMVSSQE-LAEDLTGIEILLERHQE 1333
KDR + L EA Q + + + +W+ GG ++S + DL ++ +E ++
Sbjct: 4207 KAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQ 4266
Query: 1334 HRADMEAEAPTFQALEDFSAELI------DSGHHASPEIEKKLQAVKLERDDLEKAWEKR 1387
+++ + + L + AEL+ +S H ++ L +KL D LE+ R
Sbjct: 4267 FKSEAYQQQIEMERL-NHQAELLLKKVTEESDKHT---VQDPLMELKLIWDSLEERIINR 4322
Query: 1388 K-KILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLD--SLEALMKKRDDLDKAIT 1444
+ K+ L L FQ D++ +W+ E L D ++E + K L +
Sbjct: 4323 QHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVL 4382
Query: 1445 AQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLD----RWKALKAQLIDERTKL-GDY 1499
A + + + LI E A EE A+ LQ L+ RW+ + + + +L G
Sbjct: 4383 AHQSTVEAVNKAGNDLI--ESSAGEE-ASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4439
Query: 1500 ANLKQFYRDLEELEEWISE----MLPT----ACDESYKDATNIQRKYLKHQTFAHEVDGR 1551
K F+ ++E+L++W+++ +L + E+ K+ N+ H + +
Sbjct: 4440 RQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV------HMEVCAAFEAK 4493
Query: 1552 SEQVHGVINLGNSLIECSACDGNEEAMKEQ-LEQLKEHWDHLLERTNDKGKKLNEA-SRQ 1609
E ++ G ++ + C + E +Q + LKE W+ + + N++ KL EA +
Sbjct: 4494 EETYKSLMQKGQQML--ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLA 4551
Query: 1610 QRFNTSIRDFEFWLSEAE-TLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNT 1668
F+ S++DF WL++AE TL + L + + +H++ E+ + + + +L+
Sbjct: 4552 MEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDK 4611
Query: 1669 LAEDL-LSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF-QFFQDLDDEE 1726
L S +V I +V R+ V + L +A QF +
Sbjct: 4612 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4671
Query: 1727 SWIEEKLIRVSSQ-DYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAV 1785
W+EE + S+ + D ++ L +HK + L A LK+K ++
Sbjct: 4672 EWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731
Query: 1786 GQEEIQL--RLAQFVEHWEKLKELAKARGLKLEESLEYL-QFMQNAEEEEAWINE-KNAL 1841
+ ++L L++ + W+ + + R KLEE+L + QF + W+ + L
Sbjct: 4732 ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4791
Query: 1842 AVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEES----QNK 1897
A + +L+ H+A + + + VQ + +++ + S Q +
Sbjct: 4792 AEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQ 4851
Query: 1898 EISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNG 1957
E+S++ E + + S + A Q E EF+ + W+A+ E +L+ +G
Sbjct: 4852 ELSTRWETVCALSISKQTRLEAALRQAE------EFHSVVHALLEWLAEAEQTLRFHGVL 4905
Query: 1958 ADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLK-R 2016
D D L L Q ++ L + T + D +++ H S + + +++ R
Sbjct: 4906 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4965
Query: 2017 WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLN 2076
+E++L + H+Q+L L ++L A W E + + V +
Sbjct: 4966 FEEVLAWAKQHQQRLASALAGLIAKQELLEALL----AWLQWAETTLTDKDKEVIPQEIE 5021
Query: 2077 EIRQLQKDHEDFLASLARAQAD 2098
E++ L +H+ F+ + R Q D
Sbjct: 5022 EVKALIAEHQTFMEEMTRKQPD 5043
Score = 194 bits (493), Expect = 9e-49
Identities = 436/2211 (19%), Positives = 894/2211 (40%), Gaps = 271/2211 (12%)
Query: 56 QVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTR 115
++ K D K +++KV+++T++ + ++ QK + + + R + ++
Sbjct: 2980 EIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQL 3039
Query: 116 EERFTMGHSAH--------EETKAHIEELRH--------LWDLLLELTLEKGDQLLRALK 159
+ ++G A+ + + ++ L+H DL++E + KG + L+
Sbjct: 3040 DIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDV-LLQ 3098
Query: 160 FQQYVQECADILEWIGDK-EAIATSVE-LGEDWERTEVLHKKFEDFQVEL--VAKEGRVV 215
+ QE + + + + +K + T ++ +G + +F +F EL +A GR
Sbjct: 3099 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3158
Query: 216 EVNQYANE---------------------------CAEENHPDLPLIQSKQNEVNAAWER 248
E Q E EE PDL I+ ++ +
Sbjct: 3159 ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK 3218
Query: 249 LRGLALQRQKALSNA--------ANLQRFKRDVTEAIQWIKEKEPV-LTSEDYGKDL--- 296
L A R++ + + L+ F + +A + + + PV + +E + L
Sbjct: 3219 LLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMF 3278
Query: 297 -VASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLT-LSHPSDAPQIQEMKEDLVSSWEH 354
V + +G ++++ + + + AK+ L H D D+ + W+
Sbjct: 3279 KVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD---------DVNARWKT 3329
Query: 355 IRALATSRYEKLQATYWY-HRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQ 413
+ R +LQ + RF + L WM + T + A++ P A +V+ + Q
Sbjct: 3330 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD-TEELVANQKPPS-AEFKVVKAQIQ 3387
Query: 414 QHKHEIDSYDDRFQSADETGQD--LVNANHEASDEVR--EKMEILDNNWTALLELWDERH 469
+ K DDR + + ++ + E +D+V+ +++ +LD+ W ALL + R+
Sbjct: 3388 EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN 3447
Query: 470 RQYEQC-LDFHLFYRDSEQVDSWMSRQEAFLEN-EDLGNSLGSAEALLQKHEDFEEAFTA 527
RQ E + F+ E ++ W++ E L N E +G E + +H+ E+
Sbjct: 3448 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3507
Query: 528 QEEKIITVDKTATKL-IGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQK 586
+ + L + D + +++ D ++EK+ +R LL+++L K
Sbjct: 3508 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3567
Query: 587 LY-EDSDDLKNWINK---KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQK 642
++ ED +L NW+N+ K +DY + L + + +V ++++ + K ++
Sbjct: 3568 IFGEDEVELMNWLNEVHDKLSKLSVQDYST-EGLWKQQSELRVLQEDILLRKQNVDQALL 3626
Query: 643 TGQEMIEGGHYASDNVTT---RLSEVASLWEELLEATKQKGTQLHEANQQLQ-FENNAED 698
G E+++ D V +L + + ++++ + + L +A Q + + E+
Sbjct: 3627 NGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEE 3684
Query: 699 LQRWLEDVEWQVTSEDYG--KGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEI 756
L WL+ VE ++ S + KG Q ++R L + A + +D L ++++ E+
Sbjct: 3685 LCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA-KNNKALLDSLNEVSSALLEL 3743
Query: 757 GHPDSKDIRARQ--ESLVC----RFEALKEPLATRKKKLLD--LLHLQLICRDTEDEEAW 808
RAR+ E +V R+ + + + T+K + +D +L Q + + E +W
Sbjct: 3744 -----VPWRAREGLEKMVAEDNERYRLVSDTI-TQKVEEIDAAILRSQQFDQAADAELSW 3797
Query: 809 IQETEPSATST---YLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHF 865
I ETE S L +D +++ L + I H+ I ++ + G+K++
Sbjct: 3798 ITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDIIDDLVKSGHKIMTA--C 3853
Query: 866 AAEDVASRVKSLNQ---NMESLRARAARRQNDLE-ANVQFQQYLADLHEAETWIREKEPI 921
+ E+ S K L++ N +++ + R LE A Q+ E W+ E + I
Sbjct: 3854 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI 3913
Query: 922 VDNTNYGA-----------DEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQA 970
+ A + L+ +H+ + +N G + L
Sbjct: 3914 ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL------------ 3961
Query: 971 APVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAA--DHQGIVPA 1028
+P EG + +++ +A ++ +V + + +S + K++ + IV
Sbjct: 3962 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4021
Query: 1029 VYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRL--LQRYNEFL 1086
+ E + ++ E N++ E+++ Y +L R EE R +
Sbjct: 4022 LRQPPSISAEVEKIKEQISENK-NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 4080
Query: 1087 LAYEAGDMLEWIQEK---KAENTGVELDDVWELQKKF--------------DEFQKDLN- 1128
+ D + +I E E +L DV EL +KF +F +DL
Sbjct: 4081 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED 4140
Query: 1129 -------------TNEPRLRDINKVADDL---------LFEGLLTPEGAQIRQ---ELNS 1163
E +I+ + ++L L P+ +++ ELNS
Sbjct: 4141 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4200
Query: 1164 RWGSLQRLADEQRQLLGSAHAVEVFHREA-DDTKEQIEKKCQALSAADP-GSDLFSVQAL 1221
W SL + ++ L A V +++ + ++ L++ P G+DL +V+
Sbjct: 4201 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4260
Query: 1222 QRRHEGFERDLVPLGDKVTILGETAERLSESHPDATED--LQRQKMELNEAWEDLQGRTK 1279
+ F+ + ++ L AE L + + ++ +Q MEL W+ L+ R
Sbjct: 4261 IEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERII 4320
Query: 1280 DRKESLNEAQKFYLFLSKARD-LQNWISSIGGMVSSQE-LAEDLTGIEILLERHQEHRAD 1337
+R+ L A A D L W++ G++S Q+ + D IEI L +H + D
Sbjct: 4321 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQND 4380
Query: 1338 MEAEAPTFQALEDFSAELIDS--GHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCL 1395
+ A T +A+ +LI+S G AS ++ KL+ + ++ + E+RK+ LD L
Sbjct: 4381 VLAHQSTVEAVNKAGNDLIESSAGEEAS-NLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4439
Query: 1396 -ELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDK----AITAQEGKI 1450
+ + F G + ++ W+ E L + L L K++ ++ A A+E
Sbjct: 4440 RQAKGFHGEIEDLQQWLTDTERHLLAS--KPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4497
Query: 1451 TDLEHFAESLIAD-EHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLK-QFYRD 1508
L + ++A A+ I + + ++W++++ +L + +TKL + NL +F+
Sbjct: 4498 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4557
Query: 1509 LEELEEWISEMLPTACDESYKDAT--NIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLI 1566
L++ W+++ T S + + +H+ FA+EV+ EQ+ + G L
Sbjct: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
Query: 1567 ECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEA-SRQQRFNTSIRDFEFWLSE 1625
S + +K L ++ W+ +++R ++G+ L++A R ++F+ + WL E
Sbjct: 4618 YFSQKQ-DVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEE 4676
Query: 1626 AETLLAMK-DQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQI 1684
+E L + + A D L +H+ ++ + A+ N L T D
Sbjct: 4677 SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEK-TSLADDN 4735
Query: 1685 VKKKDNVNK---RFLNVQELAAAHHEKLKEAYALF-QFFQDLDDEESW---IEEKLIRVS 1737
+K D +++ ++ + + KL+EA QF L W +E +L
Sbjct: 4736 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL--AE 4793
Query: 1738 SQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQF 1797
Q D+ V NL+ HK + EL ++Q + A +L + + +++++ +
Sbjct: 4794 DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQEL 4853
Query: 1798 VEHWEKLKELAKARGLKLEESLEYL-QFMQNAEEEEAWINE-KNALAVRGDCGDTLAATQ 1855
WE + L+ ++ +LE +L +F W+ E + L G D A +
Sbjct: 4854 STRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALR 4913
Query: 1856 SLLMKHEALENDFAVHETRVQNVCAQGEDIL----------------------NKVLQEE 1893
+L+ +H+ + G+ +L +VL
Sbjct: 4914 TLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWA 4973
Query: 1894 SQNKE-ISSKIEALNEKTPSLAKAIAAWKLQLE---DDYAFQEFNWKADVVEAWIADKET 1949
Q+++ ++S + L K L +A+ AW E D + + + V+A IA+ +T
Sbjct: 4974 KQHQQRLASALAGLIAK-QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQT 5032
Query: 1950 SLKTNGNGADLGDFLTLLAKQDTLD-ASLQSF---------QQERLPEITDLKDKLISAQ 1999
++ D +T K+ D +SLQS ++R P S
Sbjct: 5033 FMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFP----ASSLYPSGS 5088
Query: 2000 HNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAH 2050
Q + R L+ +W+Q+ + R+KL + L + E+L EFA+
Sbjct: 5089 QTQIETKNPRVNLLVSKWQQVWLLALERRRKLND---ALDRLEEL-REFAN 5135
Score = 156 bits (395), Expect = 2e-37
Identities = 445/2411 (18%), Positives = 946/2411 (39%), Gaps = 288/2411 (11%)
Query: 39 KERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTN-----IQGKYQK 93
K+++AE KL LQ + ++ + +W+ +K+N K + P ++ + ++
Sbjct: 2456 KDKIAELNTKLSK---LQKAQEESSAMMQWL-QKMNKTATKWQQTPAPTDTEAVKTQVEQ 2511
Query: 94 HQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEET--KAHIEELRHLWDLLLELTLEKG 151
++S EAE++ + EL+ E E K + E+ W L +LT+++
Sbjct: 2512 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2571
Query: 152 DQLLRALK-FQQYVQECADILEWIGDKEAIATSV-ELGEDWERTEVLHKKFEDFQVELVA 209
+L + Q+ A + +W+ +KE + + + L D ++ + E
Sbjct: 2572 QKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFAT 2631
Query: 210 KEGRVVEVNQYANECAEENHPDLPL---IQSKQNEVNAAWERLRGLALQR----QKALSN 262
++ + ++ D L ++ + V W+ L G R +A+
Sbjct: 2632 RKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK 2691
Query: 263 AANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKE 322
+ Q R +++ + + K + D + + + + +++ + ++K
Sbjct: 2692 STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQ--LETAQKMKQEIQQEKKQIKV 2749
Query: 323 LCAKAEKLTLSHPSD--APQIQEMKEDLVSSWEHIRALATSRYEKLQ-ATYWYHRFSSDF 379
A E L+ + ++ E ++ S++ + A + + LQ A H+F
Sbjct: 2750 AQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2809
Query: 380 DELSGWMNEKTAAINADE-LPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN 438
+ W++ K N + + E L+ H+ + + ++ G++L+
Sbjct: 2810 RDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL- 2868
Query: 439 ANHEASDEVREKMEI--LDNNWTALLELWDERHRQYEQCLDFHLFYRDS-EQVDSWMSRQ 495
+ S++ ++++ + NW + ER + ++ L+ L Y++ E + W+ +
Sbjct: 2869 LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2928
Query: 496 EAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555
+ LE E + K + ++ + ++ TA L+ D E +
Sbjct: 2929 QNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2988
Query: 556 IRDGLLARRDALREKAATRRRLLKESLLLQKLYED-SDDLKNWINKKKKLADDEDYKDIQ 614
L+ + D + E+ +++ L+ K +++ S + K + K+ D D Q
Sbjct: 2989 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQ 3048
Query: 615 NLKSR-VQKQQVFEKELAVNKTQLENIQKTGQEMI--EGGHYASDNVTTRLSEVASLWEE 671
++ + Q +K L K Q++ ++ Q+++ + +V ++ +A
Sbjct: 3049 AYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHST 3108
Query: 672 LLEATKQKGTQLHEANQQL-QFENNAEDLQRWLEDVEWQVTS--------EDYGKGLAEV 722
L + +K + L Q + F+N ++ + + ++ S E K +
Sbjct: 3109 LSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETI 3168
Query: 723 QNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPL 782
+ L+K LE A+ A D + + EE PD I+ E+L + L +
Sbjct: 3169 KAFLKK---LE-ALMASNDNANKTCKMMLATEETS-PDLVGIKRDLEALSKQCNKLLDRA 3223
Query: 783 ATRKKKLLDLL-HLQLICRDTEDEEAWIQETEPSATSTY-LGKDLIASKKLLNRHRVIL- 839
R++++ + L+ ++ +Q+ E S +G + + LN +V
Sbjct: 3224 QAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQK 3283
Query: 840 ENIASHEPRIQEITERGNKMVEEGHFAA---------EDVASRVKSLNQNMESLRAR--- 887
E I + + Q++ G +++ + +DV +R K+LN+ + A+
Sbjct: 3284 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3343
Query: 888 ----AARRQNDLEA------------------NVQFQQYLADLHEAETWIR---EKEPIV 922
R Q+ LE+ + +F+ A + E + R +++ V
Sbjct: 3344 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV 3403
Query: 923 DNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRV 982
+ ++ A A L L+ +AL N+A +Q +EG++ V
Sbjct: 3404 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQ----LEGIS----V 3455
Query: 983 MALYDFQARSPRE---VTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEF 1039
+A + P T++K V + + A H+ + + +
Sbjct: 3456 VAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQA 3515
Query: 1040 PMLPQR-----RREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRY-NEFLLAYEAGD 1093
+ Q RE+ + + + + Y + +++ R L Q N + + +
Sbjct: 3516 VSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVE 3575
Query: 1094 MLEWIQEKKAENTGVELDD-----VWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEG 1148
++ W+ E + + + + D +W+ Q + Q+D+ LR N D L G
Sbjct: 3576 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI-----LLRKQN--VDQALLNG 3628
Query: 1149 L-----LTPEGAQIRQE----LNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQI 1199
L T + I Q+ + +R+ + +L+ + + L A + R T E++
Sbjct: 3629 LELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA---RRLHSTHEEL 3685
Query: 1200 EKKCQALSAADPGSDLFSVQAL--------QRRHEGFERDLVPLGDKVTILGETAERLSE 1251
C L + + Q L Q R + +++ + L E + L E
Sbjct: 3686 ---CTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE 3742
Query: 1252 SHP-DATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQ-NWISSIG 1309
P A E L++ E NE + + + E ++ A +A D + +WI+
Sbjct: 3743 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWIT--- 3799
Query: 1310 GMVSSQELAEDLTGI-EILLERHQEHRADMEAEAPTFQAL--EDFSAELIDSGHH---AS 1363
E + L + +I LE+ Q + T + L +D +L+ SGH A
Sbjct: 3800 ------ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3853
Query: 1364 PEIEKKLQAVKLER-----DDLEKAWEKRKKILDQCLEL-QMFQGNCDQVESWMVAREN- 1416
E EK+ KL++ D + + +R L++ L F +++ W+ ++
Sbjct: 3854 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI 3913
Query: 1417 ------------SLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADE 1464
+LR + E + + + +DK + ++ +L I ++
Sbjct: 3914 ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK-MNKTGPQLLELSPGEGFSIQEK 3972
Query: 1465 HYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTAC 1524
+ A + + ++++ + + + I + T+ D + Q LE + E + + +
Sbjct: 3973 YVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILESLERIVERLRQPPSISA 4030
Query: 1525 D-----ESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMK 1579
+ E + N+ K Q + R E++ + G + + SA +A++
Sbjct: 4031 EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM--IARSGGTDKDISA-----KAVQ 4083
Query: 1580 EQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQA--- 1636
++L+Q+ W+++ ++ KL + +FW ++ +KD
Sbjct: 4084 DKLDQMVFIWENIHTLVEEREAKLLDVMELAE--------KFWCDHMSLIVTIKDTQDFI 4135
Query: 1637 RDLASAG---NLLKKHQ----LLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK- 1688
RDL G +++K+ Q + E+ ++ L + L +L+++ IVKK
Sbjct: 4136 RDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSI 4195
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAY-ALFQFFQDLDDEESWIEEKLIRVSSQD-YGRDLQ 1746
D +N + ++ + +KL+EA A Q+ L W++ +++S G DL+
Sbjct: 4196 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4255
Query: 1747 GVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEE--IQLRLAQFVEHWEKL 1804
V+ +++ K+ + E + ++ + AE L K ++ +Q L + W+ L
Sbjct: 4256 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4315
Query: 1805 KELAKARGLKLEESLEYL-QFMQNAEEEEAWINE-KNALAVRGDCGDTLAATQSLLMKHE 1862
+E R KLE +L L QF +E AW+ + L+ + G A + L KH
Sbjct: 4316 EERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH 4375
Query: 1863 ALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKL 1922
L+ND H++ V+ V G D++ EE+ N + +K+E LN++ ++ + K
Sbjct: 4376 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN--LQNKLEVLNQRWQNVLEKTEQRKQ 4433
Query: 1923 QLEDDYAFQE---FNWKADVVEAWIADKETSLKTNGNGADLGD------------FLTLL 1967
QL D A ++ F+ + + ++ W+ D E L + L +
Sbjct: 4434 QL--DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFE 4491
Query: 1968 AKQDTLDASLQSFQQ--ERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASA 2025
AK++T + +Q QQ R P+ SA+ N I++ L ++WE +
Sbjct: 4492 AKEETYKSLMQKGQQMLARCPK---------SAETN----IDQDINNLKEKWESV----- 4533
Query: 2026 VHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDH 2085
KL E++ L++A +L +EF + NW + E+ L+ + + Q D
Sbjct: 4534 --ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDE 4591
Query: 2086 EDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVL----ERTWKHLSDIIEER 2141
A+ + + ++ELD+ L S + ++ L + W+ + + ER
Sbjct: 4592 HKVFANEVNSHRE--QIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVER 4649
Query: 2142 EQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSL--LKETGTLESQLEAN 2199
+ L ++AR + ++F + S ++W LE LD L + +++QL +
Sbjct: 4650 GRSL--DDAR-----KRAKQFHEAWSKLMEW-LEESEKSLDSELEIANDPDKIKTQLAQH 4701
Query: 2200 KRKQKEIQAMK----------RQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLG 2249
K QK + A R L + L D D L LD S L +WD +
Sbjct: 4702 KEFQKSLGAKHSVYDTTNRTGRSLKEKTSLAD---DNLKLDDMLSE--LRDKWDTICGKS 4756
Query: 2250 LRMQHNLEQQI 2260
+ Q+ LE+ +
Sbjct: 4757 VERQNKLEEAL 4767
Score = 130 bits (326), Expect = 2e-29
Identities = 246/1229 (20%), Positives = 521/1229 (42%), Gaps = 154/1229 (12%)
Query: 22 EEIQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIME---KVNILT 77
E +++ E RY+ + + ++ ++++ + Q F + AD WI E K+ L
Sbjct: 3750 EGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLG 3809
Query: 78 DKSYE-DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEET-KAHIEE 135
D E D T+ Q + QK + E+ ++ +L K+ + T +++ K +++
Sbjct: 3810 DIRLEQDQTSAQLQVQK--TFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK 3867
Query: 136 LRHLWDLLLELTLEKGDQLLRALKF-QQYVQECADILEWIGDKEAIATSVELGEDWERTE 194
+ +D + ++ E+ QL RA Q+ + ++ W+ + ++I + +L E
Sbjct: 3868 VLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS--QLPAPALEYE 3925
Query: 195 VLHKKFEDFQV--ELVAK-EGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRG 251
L ++ E+ + EL+A+ + + ++N+ + E + + IQ K + + +++
Sbjct: 3926 TLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3985
Query: 252 LALQRQKALSNAAN-------------------LQRFKRDVTEAIQWIKEKEPVLTSEDY 292
+R AL A + ++R ++ + + + K KE + +++
Sbjct: 3986 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNV 4045
Query: 293 GKDLVASEGLFHSHKGL-ERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSS 351
D+ + L+ + K E +A K++ AKA +Q+ + +V
Sbjct: 4046 SVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA-------------VQDKLDQMVFI 4092
Query: 352 WEHIRALATSRYEKL-QATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLD 410
WE+I L R KL +F D L + + I E P G + +
Sbjct: 4093 WENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP----GIDPSVV 4148
Query: 411 RHQQH-----KHEIDSYDDRFQSADETGQDLVNANHEASDE-VREKMEILDNNWTALLEL 464
+ QQ + EID + G +L+ A E V++ ++ L++ W +L +
Sbjct: 4149 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4208
Query: 465 WDERHRQYEQCLDFHLFYRDSEQ-VDSWMSRQEAFLEN-EDLGNSLGSAEALLQKHEDFE 522
W +R + E+ + + Y+D Q V W+ L + +G L + + +++ + F+
Sbjct: 4209 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK 4268
Query: 523 EAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARR---DALREKAATRRRLLK 579
Q+ ++ ++ A L+ +S+ ++D L+ + D+L E+ R+ L+
Sbjct: 4269 SEAYQQQIEMERLNHQAELLLKKVTEESDK-HTVQDPLMELKLIWDSLEERIINRQHKLE 4327
Query: 580 ESLLLQKLYEDS-DDLKNWINKKKKLADDEDYK--DIQNLKSRVQKQQVFEKELAVNKTQ 636
+LL ++ + D+L W+ + L ++ D + ++ + K V + ++ +++
Sbjct: 4328 GALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQST 4387
Query: 637 LENIQKTGQEMIEG--GHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FE 693
+E + K G ++IE G AS N+ +L + W+ +LE T+Q+ QL A +Q + F
Sbjct: 4388 VEAVNKAGNDLIESSAGEEAS-NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFH 4446
Query: 694 NNAEDLQRWLEDVEWQVTSEDYGKGLAEV-QNRLRKHGLLESAVAARQDQVDILTDLAAY 752
EDLQ+WL D E + + GL E + +L H + +A A+++ L
Sbjct: 4447 GEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQ 4506
Query: 753 FEEIGHPDSKDIRARQE--SLVCRFEALKEPLATRKKKLLDLLHLQLICRDT-EDEEAWI 809
P S + Q+ +L ++E+++ L RK KL + L+L + ++ +D W+
Sbjct: 4507 MLA-RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWL 4565
Query: 810 QETEPS---ATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERG---------- 856
+ E + A+ L D + + ++ H+V + SH +I E+ + G
Sbjct: 4566 TQAEQTLNVASRPSLILDTVLFQ--IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQ 4623
Query: 857 --------------------NKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE 896
++VE G + +D R K ++ L + L+
Sbjct: 4624 DVVLIKNLLISVQSRWEKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4682
Query: 897 ANVQ-------FQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLN 949
+ ++ + LA E + + K + D TN G LK+ + D
Sbjct: 4683 SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN------RTGRSLKEKTSLADDNL 4736
Query: 950 SFGDSMKALRNQANAC------QQQQAAPVEGVAGE--QRVMALYDFQARSPREVTMKK- 1000
D + LR++ + +Q + +G+ + AL D+ R ++ +
Sbjct: 4737 KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP 4796
Query: 1001 --GDVLTLLSSI-NKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQ 1057
GD+ +++ I N ++ E V A ++R A + L + R++ + +
Sbjct: 4797 VHGDIDLVMNLIDNHKAFQKELGKRTSSVQA--LKRSARE----LIEGSRDDSSWVKVQM 4850
Query: 1058 EQIENQYRSLLDRAEERRRRL---LQRYNEFLLAYEAGDMLEWIQEKKAENT----GVEL 1110
+++ ++ ++ + ++ RL L++ EF A +LEW+ E AE T GV
Sbjct: 4851 QELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA--LLEWLAE--AEQTLRFHGVLP 4906
Query: 1111 DDVWELQKKFDEFQKDLNTNEPRLRDINK 1139
DD L+ D+ ++ + E + ++NK
Sbjct: 4907 DDEDALRTLIDQHKEFMKKLEEKRAELNK 4935
Score = 125 bits (314), Expect = 5e-28
Identities = 431/2270 (18%), Positives = 886/2270 (39%), Gaps = 316/2270 (13%)
Query: 273 VTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTL 332
V + + W+ E + L ++G DL + E +HK + R + +KE AK ++ +
Sbjct: 648 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQM 705
Query: 333 SHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKT-- 390
+ P +++ ++ + L TSR ++ ++ S +EL W+NEK
Sbjct: 706 TAPLKLTYAEKLHR---LESQYAKLLNTSRNQERHLDTLHNFVSRATNELI-WLNEKEEE 761
Query: 391 -AAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVRE 449
A + E T++A + D H + E+D ++ +S E + L+ NH A +
Sbjct: 762 EVAYDWSERNTNIARKK---DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEA 818
Query: 450 KMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENE---DLGN 506
+ W+ +L+L + ++ + F+ D+++ ++ + ++ + D +
Sbjct: 819 YRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS 878
Query: 507 SLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSE-------NIKAI--- 556
S+ E L+Q+ + +E + I + A +I +S+ IKAI
Sbjct: 879 SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDY 938
Query: 557 ---------RDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADD 607
D + ++ R K E+++ + K ++ ++ +
Sbjct: 939 RQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--E 996
Query: 608 EDYKDIQNL--KSRVQKQQVFEKELAVNKTQLENIQKTG----QEMIEGGHYASDNVTTR 661
+ Y+++ L +S + + V +N +++ I+ + + M+ G H
Sbjct: 997 QQYQNVLTLWHESHINMKSVVSWHYLIN--EIDRIRASNVASIKTMLPGEHQQV------ 1048
Query: 662 LSEVASLWEELLEATKQKGTQLHEANQQLQFENNA--EDLQRWLEDVEWQVTSED-YGKG 718
LS + S +E+ LE +++ QL+ E N + Q L+ E + E Y
Sbjct: 1049 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 1108
Query: 719 LAEVQN-RLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEA 777
++EV+N RLR LE+ +D+ ++ + E +S QE L E
Sbjct: 1109 ISEVRNIRLR----LENC----EDR--LIRQIRTPLERDDLHESVFRITEQEKLKKELER 1158
Query: 778 LKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY-LGKDLIASKKLLNRHR 836
LK+ L T K + + + + Y + I K +N
Sbjct: 1159 LKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVN--- 1215
Query: 837 VILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQ---N 893
++L+N + E ++ K+ EE A+ + +++L ++ R+ ++ +
Sbjct: 1216 LVLKNTQAAEALVKLYE---TKLCEEEAVIAD--KNNIENLISTLKQWRSEVDEKRQVFH 1270
Query: 894 DLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAF-------LL 946
LE +Q + ++D E + KE +D + +E A L+++ + L
Sbjct: 1271 ALEDELQKAKAISD----EMFKTYKERDLD---FDWHKEKADQLVERWQNVHVQIDNRLR 1323
Query: 947 DLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTL 1006
DL G S+K R+ + ++ V QR + + Q + + + + L
Sbjct: 1324 DLEGIGKSLKYYRDTYHPLDDW----IQQVETTQR--KIQENQPENSKTLATQLNQQKML 1377
Query: 1007 LSSINKDWWKVE-----AADHQGIVPAVYVRRLAH-------DEFPMLPQRRREEPGNIT 1054
+S I K++ A + V ++ + + + P+ +R + I
Sbjct: 1378 VSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII 1437
Query: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVW 1114
Q + +Y +L+ L+ +Y +F AGD L+ ++E E +E ++
Sbjct: 1438 QEFMDLRTRYTALV--------TLMTQYIKF-----AGDSLKRLEE---EEKSLE-EEKK 1480
Query: 1115 ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADE 1174
E +K E QK ++ L+D K + ++ E ++E S +LQ +
Sbjct: 1481 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE--ALQTI--- 1535
Query: 1175 QRQLLGSAHAVEVFHREADDTKEQI------------EKKCQALSAADPGSDLFSVQALQ 1222
QL + H ++ E ++ ++Q+ E Q + G + +
Sbjct: 1536 --QLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVA 1593
Query: 1223 RRHEGFERDLVPLGDKVTILGETAERLSESHP-----DATEDLQRQKMELNEAWEDLQGR 1277
R + ++ L + D +L +T RL D T +L++ + + E +D+QG
Sbjct: 1594 ERQQEYKEKLQGICD---LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGS 1650
Query: 1278 TKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRAD 1337
+ E + + F ++ +S + Q+L E E L + ++ + +
Sbjct: 1651 AQALAEVVKNTENF------LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE 1704
Query: 1338 MEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLEL 1397
++ T E + + +IE L + D E+A K K++++Q
Sbjct: 1705 LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQ--NG 1762
Query: 1398 QMFQ--------GNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGK 1449
FQ G D+V ++ E + ++ ++L +K + I +Q
Sbjct: 1763 THFQEGDGKSAIGEEDEVNGNLL--ETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQA 1820
Query: 1450 ITDLEHFAESLIADE-HYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYAN-----LK 1503
+ A+ L+ + Y E +LQ+ + K + E K + L+
Sbjct: 1821 VIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELE 1880
Query: 1504 QFYRDLEELEEWI--SEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINL 1561
+F D E E W+ SE + D + K + ++F+ +V + +
Sbjct: 1881 KFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITIS 1940
Query: 1562 GNSLIE----CSACDGNE-------EAMKEQLEQLKEHWDHLLERTNDKGKKLNE-ASRQ 1609
GN ++E CS DG + ++ +L+ + + L + N G L + +
Sbjct: 1941 GNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY 2000
Query: 1610 QRFNTSIRDFEFWLSEAETLLA---MKDQARDLASAGNLLKKHQLLEREMLAREDALKDL 1666
Q + + L E + + A D + L++ + L+ ++ +++ A++ L
Sbjct: 2001 QHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKL 2060
Query: 1667 NTLAEDLLSS-GTF--NVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQD-L 1722
AE LL + G+ + I K D++ R+ ++ + +EKL+ QD L
Sbjct: 2061 KKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGL 2120
Query: 1723 DDEESWIEEKLIRVSSQDYGR---DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL 1779
D+ W+ + S ++ G+ + +Q+++ K+ LE ++ + +I + + +K
Sbjct: 2121 DEMLDWMGN--VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKF 2178
Query: 1780 KD-----KAAVGQEEIQLRLAQFVEHWEKLKE-LAKARGLKLEESLEYLQFMQNAEEEEA 1833
+ A+ Q +++ A+F E K KE LAK LK + L F +E+ +
Sbjct: 2179 METTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL----FENLSEKLQT 2234
Query: 1834 WINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEE 1893
++ K D S M+ ++F H+ ++ + + ++I + L +
Sbjct: 2235 FLETKTQALTEVDVPGKDVTELSQYMQEST--SEFLEHKKHLEVLHSLLKEISSHGLPSD 2292
Query: 1894 -----SQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKE 1948
+ +S K + + + +A+ + + QL+ AFQ +++WI KE
Sbjct: 2293 KALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLD---AFQVL---VKSLKSWI--KE 2344
Query: 1949 TSLKT-----NGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKD------KLIS 1997
T+ K + DLG L +DT LQ + PEI + + LIS
Sbjct: 2345 TTKKVPIVQPSFGAEDLGKSL-----EDT--KKLQEKWSLKTPEIQKVNNSGISLCNLIS 2397
Query: 1998 AQHNQSKAI-------------------EERYA--ALLKRWEQLLEAS-------AVHRQ 2029
A +KAI EE +A L + + + S + +
Sbjct: 2398 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2457
Query: 2030 KLLE---KQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHE 2086
K+ E K LQKA++ ++SA+ W +KM + ++ + + ++ E
Sbjct: 2458 KIAELNTKLSKLQKAQE-------ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVE 2510
Query: 2087 DFLASLARAQADFKCLLELDQQIKAL-----GVPSSPYTWLTVEVLERTWKHLSDIIEER 2141
+ A + + + EL ++ L P +P + ++ W+ L+ + +R
Sbjct: 2511 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2570
Query: 2142 EQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYF-LDGSLLKETGTLESQLEANK 2200
+Q+L+ E + + F+ + + QW++E + G L + L +Q + +
Sbjct: 2571 QQKLE-ESSNNLTQFQTVE------AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2623
Query: 2201 RKQKEIQAMKRQLTKIVDLGDNL-----EDALILDI-KYSTIGLAQQWDQLY-QLGLRMQ 2253
+E K Q ++ G + ED + I K + Q+WD L QL R
Sbjct: 2624 ILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCD 2683
Query: 2254 HNLEQQIQAKDIKGVS-EETLKEFSTIYKHFDENLTGRL---THKEFRSCLRGLNYYLPM 2309
++Q I +K + L+ S D L+ L TH + + + L M
Sbjct: 2684 W-IDQAI----VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN--QQLETAQKM 2736
Query: 2310 VEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENI-KSSDEIE 2358
+E + E K K A+ V E+Y + ++ E I KS ++E
Sbjct: 2737 KQEIQQEKKQIKVAQALCEDLSALVK-EEYLKAELSRQLEGILKSFKDVE 2785
Score = 124 bits (312), Expect = 9e-28
Identities = 433/2368 (18%), Positives = 888/2368 (37%), Gaps = 379/2368 (16%)
Query: 6 KETVVESSGPKVLETAEEIQERRQEV---LTRYQSFK----ERVAERGQKLEDSYHLQVF 58
K ++SS +++ +++ R + +T+Y F +R+ E + LE+ V
Sbjct: 1425 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVE 1484
Query: 59 KRDADDLGKWIMEKVNILTD--KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKT-- 114
K A +L KW+ L D K+ + P + K + E+ TK +SE +T
Sbjct: 1485 K--AKELQKWVSNISKTLKDAEKAGKPP------FSKQKISSEEISTKKEQLSEALQTIQ 1536
Query: 115 ---REERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADIL 171
+ M E + ++ L+ ++LL +LK Q Q D+
Sbjct: 1537 LFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS----------ESLKQLQESQTSGDVK 1586
Query: 172 EWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPD 231
+++ +A ER + +K + L E R++ + + +
Sbjct: 1587 V---EEKIVA---------ERQQEYKEKLQGICDLLTQTENRLIGHQEAF--MIGDGTVE 1632
Query: 232 LPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSED 291
L QSKQ E+ + ++G A + + N N ++KE L+ ED
Sbjct: 1633 LKKYQSKQEELQ---KDMQGSAQALAEVVKNTEN-------------FLKENGEKLSQED 1676
Query: 292 YGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSS 351
A++ K+ E K E+L L ++ ++
Sbjct: 1677 K---------------------ALIEQKLNEAKIKCEQLNLKAEQSKKELDKV------- 1708
Query: 352 WEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411
+ EK+ A + + L W++ N D+ ++ AG
Sbjct: 1709 ---VTTAIKEETEKVAAVKQLEESKTKIENLLDWLS------NVDK-DSERAG------- 1751
Query: 412 HQQHKHEIDSYDDRFQSADETG----QDLVNANHEASDEVREKMEILDNNWTALLELWDE 467
+HK I+ FQ D +D VN N +D + +N L + + +
Sbjct: 1752 -TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN----LNQQYQK 1806
Query: 468 RHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTA 527
Q+E+ + H Q + + SA+ LL+K + +
Sbjct: 1807 VKAQHEKIISQH---------------QAVIIATQ-------SAQVLLEKQGQY---LSP 1841
Query: 528 QEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKL 587
+E++ + + K+ HY++ ++ EK L+E L +K
Sbjct: 1842 EEKEKLQKNMKELKV----HYETALAES-------------EKKMKLTHSLQEEL--EKF 1882
Query: 588 YEDSDDLKNWINKKKKLADDEDY--KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQ 645
D + ++W+ + ++ ++ + DI L +++++Q+ F +++ +K L I +G
Sbjct: 1883 DADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGN 1942
Query: 646 EMIEGGHYASDN-------------VTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ- 691
++E S V +L + L G L + + Q
Sbjct: 1943 RVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQH 2002
Query: 692 FENNAEDLQRWLEDVEWQVT---SEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTD 748
+E+ + L L+ E + SE +Q +L + L+ ++++Q V+ L
Sbjct: 2003 YEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKK 2062
Query: 749 LAAYFEEIGH---PDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDE 805
A + P DI+ + +V R+E L + + R +KL L L +D DE
Sbjct: 2063 TAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2122
Query: 806 EA-WIQETEPSATST-YLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEG 863
W+ E S + + A + +++++ ++ ++IA + I + E+ K +E
Sbjct: 2123 MLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETT 2182
Query: 864 HFAAEDVASRVKSLNQNMESLRARAAR----------RQNDLEANVQFQQYLADLHEAET 913
S SL M+ L AR + + +L+ V+ + L++ + +T
Sbjct: 2183 D------PSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE--KLQT 2234
Query: 914 WIREKEPIVDNTNY-GADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQ--ANACQQQQA 970
++ K + + G D +++ + L+ + + +L + ++ +A
Sbjct: 2235 FLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA 2294
Query: 971 APVEGVAGEQRVMALYDFQARSPREVT---MKKGDVLTLLSSINKDWWKVEAADHQGIVP 1027
+E + + + +E ++ D +L K W K VP
Sbjct: 2295 LVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKK----VP 2350
Query: 1028 AVYVRRLAHDEFPMLPQRRR--EEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEF 1085
V A D L ++ E+ T +++ N SL + + +
Sbjct: 2351 IVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA-----VTTPAKA 2405
Query: 1086 LLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLL 1145
+ A ++G + E T ++ W K L + + + DI+ +DL
Sbjct: 2406 IAAVKSGGAV-----LNGEGTATNTEEFWA--------NKGLTSIKKDMTDISHGYEDL- 2451
Query: 1146 FEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQA 1205
GLL + ELN++ LQ+ +E ++ +++ K
Sbjct: 2452 --GLLLKDKIA---ELNTKLSKLQKAQEESSAMM--------------QWLQKMNKTATK 2492
Query: 1206 LSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKM 1265
+D +V+ +++ FE +L +KV L + L E +PD E + ++M
Sbjct: 2493 WQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQM 2552
Query: 1266 --ELNEAWEDLQGRTKDRKESLNE-AQKFYLFLSKARDLQNW-------ISSIGGM-VSS 1314
E++ W++L T DR++ L E + F + L+ W +S +G + +
Sbjct: 2553 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP 2612
Query: 1315 QELAEDLTGIEILLERHQEHRADMEAEAPTFQAL-----EDFSAELIDSGHHASPEIEKK 1369
L ++ILL+ + E Q + ED S I ++++
Sbjct: 2613 NMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGI---------VKEQ 2663
Query: 1370 LQAVKLERDDLEKAWEKRKKILDQCL-ELQMFQGNCDQVESWMVARENSLRSDDKSSL-- 1426
L AV + D L R +DQ + + +Q + + +N L S S
Sbjct: 2664 LAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP 2723
Query: 1427 DSLEALMKKRDDLDKAITAQEGKITDLEHFAESL--IADEHYAKEEIATRLQRVLDRWKA 1484
D++ ++ + + I ++ +I + E L + E Y K E++ +L+ +L +K
Sbjct: 2724 DAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKD 2783
Query: 1485 LKAQLIDERTKL-GDYANLKQFYRDLEELEEWISEMLPTACDESYKD-----ATNIQRKY 1538
++ + + L A+ QF + + + W L T +E K ++
Sbjct: 2784 VEQKAENHVQHLQSACASSHQFQQMSRDFQAW----LDTKKEEQNKSHPISAKLDVLESL 2839
Query: 1539 LK-HQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE-AMKEQLEQLKEHWDHLLERT 1596
+K H+ F+ + +S I G +L+ G+E+ A++ QL +K +WD ++
Sbjct: 2840 IKDHKDFSKTLTAQSHMYEKTIAEGENLL--LKTQGSEKAALQLQLNTIKTNWDTFNKQV 2897
Query: 1597 NDKGKKLNEA-SRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLERE 1655
++ KL E+ + ++ + W+ + + L D A N + K + L++E
Sbjct: 2898 KERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKE 2957
Query: 1656 MLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYAL 1715
M ++ LN A LLS + + + + ++ ++ V E + L+
Sbjct: 2958 MDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK 3017
Query: 1716 FQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775
F+ FQ++ E + +L Q D G Q K+ + A+++ +D+
Sbjct: 3018 FKEFQEVSKES---KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDL 3074
Query: 1776 AEKLKDKAAV------GQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829
A++L V G ++ L++ + L + + LE L+ + QN
Sbjct: 3075 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3134
Query: 1830 EE-----EAWINEKNALAVRGDCGDTL----AATQSLLMKHEAL--ENDFAVHETRVQNV 1878
E + +E +++A G +TL ++ L K EAL ND A ++
Sbjct: 3135 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM-- 3192
Query: 1879 CAQGEDILNKVLQEESQNKEISSK--IEALNEKTPSLAKAIAAWKLQLEDDY-AFQEFNW 1935
+ EE+ + K +EAL+++ L A + Q+E +EF
Sbjct: 3193 ----------LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYS 3242
Query: 1936 KADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDK- 1994
K + E ++ G + + +T++ L F+ + EI L+ K
Sbjct: 3243 KLKEFSILLQKAEEHEESQG---------PVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3293
Query: 1995 ---------LI--SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAED 2043
LI +A+ ++ +E + RW+ L +K+ ++ LQ+A
Sbjct: 3294 QDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL-------NKKVAQRAAQLQEALL 3346
Query: 2044 LFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLA-RAQADFKCL 2102
F +L +W EE ++ + ++ + Q + L L ++ + +
Sbjct: 3347 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3406
Query: 2103 LELDQQIKALGVPSSPYTWL-TVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQE 2161
++I P+ L + +L+ W+ L + E R ++L+ + Q+
Sbjct: 3407 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISV-------VAQQ 3459
Query: 2162 FEQNASTFLQWILETRAYFLDGSLL-KETGTLESQLEANKRKQKEIQAMKRQLTKIVDLG 2220
F + +W+ ++ + + LE Q+ +K + +I + L + V +G
Sbjct: 3460 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3519
Query: 2221 DNL------EDALILDIKYSTIGLAQQW 2242
+L ED D+ S + +Q W
Sbjct: 3520 QSLKVLSSREDK---DMVQSKLDFSQVW 3544
Score = 122 bits (306), Expect = 4e-27
Identities = 304/1638 (18%), Positives = 627/1638 (38%), Gaps = 208/1638 (12%)
Query: 16 KVLETAEE---IQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIME 71
KVL + E+ +Q + Y +E+ R + L+ + + ++F D +L W+ E
Sbjct: 3523 KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNE 3582
Query: 72 KVNILTDKSYEDPTNIQGKYQKHQSLEA--------EVQTKSRLMSELE---KTREERFT 120
+ L+ S +D + +G +++ L + L++ LE +T +
Sbjct: 3583 VHDKLSKLSVQDYST-EGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL 3641
Query: 121 MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAI 180
+ E KA +++ L + + TLE+ QL R L ++ W+ E
Sbjct: 3642 IIQDKLEAIKARYKDITKLSTDVAK-TLEQALQLARRLHSTH-----EELCTWLDKVEVE 3695
Query: 181 ATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYA-----NECAEENHPDLPL- 234
S E T+VL K E Q ++ KE + N A NE + +P
Sbjct: 3696 LLSYE-------TQVL-KGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWR 3747
Query: 235 ----IQSKQNEVNAAWERLRGLALQRQKALSNAA-NLQRFKRDVTEAIQWIKEKEPVLTS 289
++ E N + + Q+ + + A Q+F + + WI E E L S
Sbjct: 3748 AREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMS 3807
Query: 290 -EDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDL 348
D + + K + D + +L K+ + + Q + K D
Sbjct: 3808 LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK 3867
Query: 349 V-SSWEHIRALATSRYEKLQ-ATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGE 406
V +++ I + + RY +L+ A ++F ++EL W+ E + I+ +LP E
Sbjct: 3868 VLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS--QLPAPALEYE 3925
Query: 407 VLLDRHQQHKHE---IDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLE 463
L + ++H+ I + ++TG L+ + ++EK D ++ + E
Sbjct: 3926 TLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3985
Query: 464 LWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEE 523
+R ++ + + D ++D + E +E S+ + +++ +
Sbjct: 3986 DVKKRAVALDEAISQSTQFHD--KIDQILESLERIVERLRQPPSISAEVEKIKEQISENK 4043
Query: 524 AFTAQEEKII----TVDKTATKLIGDDHYDSENI--KAIRDGLLAR-------RDALREK 570
+ EK+ T+ + ++I ++I KA++D L + E+
Sbjct: 4044 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 4103
Query: 571 AATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQN--LKSRVQKQQVFEK 628
A +LL L +K + D L I + D + I +K + + + +
Sbjct: 4104 EA---KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 4160
Query: 629 ELAVNKTQLENIQKTGQEMIEG-GHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEAN 687
E+ + +L+ + G E+I G V + E+ S W+ L +A K + +L EA
Sbjct: 4161 EIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAM 4220
Query: 688 QQ-LQFENNAEDLQRWLEDVEWQVTS-EDYGKGLAEVQNRLRKHGLLESAVAARQDQVDI 745
Q +Q+++ + + W++ ++ S G L V+ ++ + +S +Q +++
Sbjct: 4221 QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER 4280
Query: 746 LTDLAAYF--EEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLD-LLHLQLICRDT 802
L A + D ++ L +++L+E + R+ KL LL L
Sbjct: 4281 LNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHAL 4340
Query: 803 EDEEAWIQETEPSATSTY-LGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVE 861
++ AW+ TE + +G D A + L +H V+ ++ +H+ ++ + + GN ++E
Sbjct: 4341 DELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIE 4400
Query: 862 -EGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANV-QFQQYLADLHEAETWIREKE 919
A ++ ++++ LNQ +++ + +R+ L+ + Q + + ++ + + W+ + E
Sbjct: 4401 SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTE 4460
Query: 920 -PIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAG 978
++ + G E A L H + ++ K+L + G
Sbjct: 4461 RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQK----------------G 4504
Query: 979 EQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDE 1038
+Q + AR P+ + ++ ++++ + W VE ++ LA +
Sbjct: 4505 QQML-------ARCPKSA---ETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEF 4554
Query: 1039 FPMLPQ-----RRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGD 1093
L + E+ N+ R I + +D + + + + + G
Sbjct: 4555 HNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGT 4614
Query: 1094 MLEWIQEKK----AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGL 1149
L++ +K+ +N + + WE KV L+ G
Sbjct: 4615 HLKYFSQKQDVVLIKNLLISVQSRWE-----------------------KVVQRLVERGR 4651
Query: 1150 LTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAA 1209
+ + ++ + W L +E + L S + A
Sbjct: 4652 SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEI----------------------AN 4689
Query: 1210 DPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKM--EL 1267
DP D Q Q H+ F++ L T L E A ++L+ M EL
Sbjct: 4690 DP--DKIKTQLAQ--HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4745
Query: 1268 NEAWEDLQGRTKDRKESLNEAQKFY-LFLSKARDLQNWISSI-GGMVSSQELAEDLTGIE 1325
+ W+ + G++ +R+ L EA F F + L +W+ + + Q + D+ +
Sbjct: 4746 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4805
Query: 1326 ILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWE 1385
L++ H+ + ++ + QAL+ + ELI+ S VK++ +L WE
Sbjct: 4806 NLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-------SWVKVQMQELSTRWE 4858
Query: 1386 --------KRKKILDQCLELQMFQGNCDQVESWMVARENSLR-----SDDKSSLDSL--- 1429
K+ ++ + + F + W+ E +LR DD+ +L +L
Sbjct: 4859 TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ 4918
Query: 1430 -----EALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKA 1484
+ L +KR +L+KA T + + +S+ +H+ I R + VL K
Sbjct: 4919 HKEFMKKLEEKRAELNKATTMGDTVLAICH--PDSITTIKHWI-TIIRARFEEVLAWAKQ 4975
Query: 1485 LKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESY----KDATNIQRKYLK 1540
+ +L A L LE L W+ T D+ ++ ++ +
Sbjct: 4976 HQQRLASA------LAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE 5029
Query: 1541 HQTFAHEVDGRSEQVHGV 1558
HQTF E+ + V V
Sbjct: 5030 HQTFMEEMTRKQPDVDKV 5047
Score = 105 bits (262), Expect = 5e-22
Identities = 429/2370 (18%), Positives = 878/2370 (37%), Gaps = 423/2370 (17%)
Query: 187 GEDWERTEVLHKKFEDF----QVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNE- 241
GE + L +FEDF Q V + ++ + N C + L + ++ E
Sbjct: 1043 GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEE 1102
Query: 242 --VNAAWERLRGLALQRQKALSNAANLQRF---KRDVTEAIQWIKEKEPVLTSEDYGKDL 296
N +R + L+ + R + D+ E++ I E+E + + KD
Sbjct: 1103 SVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD- 1161
Query: 297 VASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIR 356
+L +++K +E ++A + S P ++ ++ + +
Sbjct: 1162 ---------------DLGTITNKCEEFFSQA-----AASSSVPTLRSELNVVLQNMNQVY 1201
Query: 357 ALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHK 416
+++++ +KL+ + + + L K A + D E L+ +Q +
Sbjct: 1202 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA--VIADKNNIENLISTLKQWR 1259
Query: 417 HEID-------SYDDRFQSADETGQDLVNANHEAS---DEVREKMEILDNNWTALLELWD 466
E+D + +D Q A ++ E D +EK + L W + D
Sbjct: 1260 SEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1319
Query: 467 ERHRQYEQCLDFHLFYRDS-EQVDSWMSRQEAF---LENEDLGNSLGSAEALLQKHEDFE 522
R R E +YRD+ +D W+ + E ++ NS A L Q
Sbjct: 1320 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQ------ 1373
Query: 523 EAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLL------ARRDALREKAATRRR 576
Q+ + ++ +K+ Y + ++D L A D+ ++ RRR
Sbjct: 1374 -----QKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRR 1428
Query: 577 LLKESLLLQKLYED-------------------SDDLKNWINKKKKLADD-----EDYKD 612
+ + L+ + + D D LK ++K L ++ E K+
Sbjct: 1429 MQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKE 1488
Query: 613 IQNLKSRVQK---------------QQVFEKELAVNKTQLEN--------IQKTGQEMIE 649
+Q S + K Q++ +E++ K QL + K G +M +
Sbjct: 1489 LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTD 1548
Query: 650 GGHYASDNVTTRLSEVASLW-----EELLEATKQKGTQLHE---ANQQLQFENNAEDLQR 701
+ L E +L ++L E+ ++ E A +Q +++ + +
Sbjct: 1549 EERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICD 1608
Query: 702 WLEDVEWQVTSED----YGKGLAEVQNRLRKHGLLESAV-AARQDQVDILTDLAAYFEEI 756
L E ++ G G E++ K L+ + + Q +++ + + +E
Sbjct: 1609 LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1668
Query: 757 GHPDSKDIRARQESLVCRFEALKEPL---ATRKKKLLDLLHLQLICRDTEDEEAWIQETE 813
G S++ +A E + + E L A + KK LD + I +TE A +++ E
Sbjct: 1669 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA-VKQLE 1727
Query: 814 PSATSTYLGKDLIA-----SKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAE 868
S T D ++ S++ +H+ ++E +H + G + G+
Sbjct: 1728 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1787
Query: 869 DVASRV----KSLNQNMESLRARAARRQNDLEANV---QFQQYLADLHEAETWIREKEPI 921
DV +V ++LNQ + ++A+ + + +A + Q Q L + EKE +
Sbjct: 1788 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1847
Query: 922 VDN-----TNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGV 976
N +Y + +K + +L F + +Q+ G
Sbjct: 1848 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 1907
Query: 977 AGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQ--GIVPAVYVRRL 1034
+M Q +V KGD+ + S N+ ++ + G V R
Sbjct: 1908 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHRE 1967
Query: 1035 AHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDM 1094
+ R R ++ + + N + L+D+ Q Y + AG
Sbjct: 1968 VQRKLDHATDRFR----SLYSKCNVLGNNLKDLVDK--------YQHYEDASCGLLAGLQ 2015
Query: 1095 LEWIQEKKAENTGVELDDVWELQKKFDE---FQKDLNTNEPRLRDINKVADDLL-FEGLL 1150
K + + +D LQ++ +E Q +++ + + + K A+ LL G L
Sbjct: 2016 ACEATASKHLSEPIAVDPK-NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSL 2074
Query: 1151 TPEGAQIRQELNS---RWGSLQRLADEQRQ----LLGSAHAVEVFHREADDTKEQIEKKC 1203
P I++ L+ R+ L + +E+ + L + +V+ E D +E
Sbjct: 2075 LPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL 2134
Query: 1204 QALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSES-HPDATEDLQR 1262
+ S ++Q + ++ E+D+ + + E ++ E+ P LQ
Sbjct: 2135 KEQGQVPLNST--ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQA 2192
Query: 1263 QKMELNEAWEDLQGRTKDRKESLNEAQ-KFYLFLSKARDLQNWISSIGGMVSSQELAE-D 1320
+ +L+ + + + K+ + E + K LF + + LQ ++ + +Q L E D
Sbjct: 2193 KMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLET-----KTQALTEVD 2247
Query: 1321 LTGIEI--LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIE-KKLQAVKLER 1377
+ G ++ L + QE ++ + L E+ G + + +K + +
Sbjct: 2248 VPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKF 2307
Query: 1378 DDLEKAWEKRKKILDQCLE-LQMFQGNCDQVESWMV--------------------AREN 1416
++E +++K+ + C E L FQ ++SW+ + E+
Sbjct: 2308 KEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLED 2367
Query: 1417 SLRSDDKSSLDSLEALMKKRDDLD------------KAITAQEGKITDLEHFAESLIADE 1464
+ + +K SL + E + KAI A + L + +E
Sbjct: 2368 TKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEE 2427
Query: 1465 HYA-------KEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWIS 1517
+A K+++ D LK ++ + TKL + L++ + + +W+
Sbjct: 2428 FWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL---SKLQKAQEESSAMMQWLQ 2484
Query: 1518 EMLPTACD----ESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDG 1573
+M TA + D ++ + ++++F E+ +V + + L+E +
Sbjct: 2485 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2544
Query: 1574 NEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQ-QRFNTSIRDFEFWLSEAETLLAM 1632
K+ L ++ W L + T D+ +KL E+S +F T + WL E E ++++
Sbjct: 2545 EAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV 2604
Query: 1633 KDQARDLASAGNLL----KKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688
L+ N+L ++ Q+L +E R+ + L + +LS +
Sbjct: 2605 ---LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS----------RPG 2651
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748
++ + R + ++LAA + L D WI++ +++ S Y L+ +
Sbjct: 2652 EDPSLRGIVKEQLAAVTQK-------WDSLTGQLSDRCDWIDQAIVK--STQYQSLLRSL 2702
Query: 1749 QNLLKK-HKRLEGELV--AHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLK 1805
+ L +L L H A+ L+ A+K+K + + QE+ Q+++AQ + E L
Sbjct: 2703 SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE--IQQEKKQIKVAQAL--CEDLS 2758
Query: 1806 ELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALE 1865
L K LK E S + + +L + +E
Sbjct: 2759 ALVKEEYLKAELSRQ---------------------------------LEGILKSFKDVE 2785
Query: 1866 NDFAVHETRVQNVCAQGEDILNKVLQEESQNKE--ISSKIEALNEKTPSLAKAIAAWKLQ 1923
H +Q+ CA Q+ S++ + + +K E N+ P A
Sbjct: 2786 QKAENHVQHLQSACASSHQ-----FQQMSRDFQAWLDTKKEEQNKSHPISA--------- 2831
Query: 1924 LEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQE 1983
K DV+E+ I D + KT + QS E
Sbjct: 2832 ------------KLDVLESLIKDHKDFSKT---------------------LTAQSHMYE 2858
Query: 1984 RLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAED 2043
+ I + ++ L+ Q ++ A++ + + W+ +++ E++ L+++ +
Sbjct: 2859 K--TIAEGENLLLKTQGSEKAALQLQLNTIKTNWD-------TFNKQVKERENKLKESLE 2909
Query: 2044 LFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLL 2103
+++ + L W +K + NL E C+ + E+ +A L Q
Sbjct: 2910 KALKYKEQVETLWPWIDKCQNNLEEIKFCLD-------PAEGENSIAKLKSLQK------ 2956
Query: 2104 ELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFE 2163
E+DQ VE+L T L + E ++ + E ++ +M E
Sbjct: 2957 EMDQHFG------------MVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE-- 3002
Query: 2164 QNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL 2223
L ++ + L+ T + E +K ++++Q K QL D+ D+L
Sbjct: 3003 ---------QLHSKKFCLENM----TQKFKEFQEVSKESKRQLQCAKEQL----DIHDSL 3045
Query: 2224 EDALILDIKYSTIGLAQQWD---QLYQLGLRMQHNLEQQIQAKDIKGVSEETL------K 2274
+ KY T+ QQ +Q+ L + + ++A D KG S+ L +
Sbjct: 3046 GSQAYSN-KYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQ 3104
Query: 2275 EFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHE-PKFEKFLDAVDPGRKGY 2333
E ST+ + DE + T L+G+ ++ + E + +F+ LD++ P +
Sbjct: 3105 EHSTLSQQVDEKCSFLETK------LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3158
Query: 2334 VSL----EDYTAFLIDKESENIKSSDEIEN 2359
+L E AFL K+ E + +S++ N
Sbjct: 3159 ETLQKQKETIKAFL--KKLEALMASNDNAN 3186
Score = 90.1 bits (222), Expect = 2e-17
Identities = 319/1812 (17%), Positives = 680/1812 (37%), Gaps = 242/1812 (13%)
Query: 697 EDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAV--------AARQDQVDILTD 748
+DL W+++++ Q+ ++G L V++ L H + A+ A+ ++ +
Sbjct: 649 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP 708
Query: 749 LAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAW 808
L + E H R ES + + +++ LD LH + R T +E W
Sbjct: 709 LKLTYAEKLH--------RLESQYAKL----LNTSRNQERHLDTLH-NFVSRAT-NELIW 754
Query: 809 IQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAE 868
+ E E + + + + H ++ + E I+ + E +++ E H A
Sbjct: 755 LNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 814
Query: 869 DVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYG 928
+ + ++ + + ++ N + ++ D EA ++R + + Y
Sbjct: 815 TIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR-KYS 873
Query: 929 ADEEAAGALLK--------------KHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVE 974
D ++ L+ ++++ + +L ++ L+ + + C + + P++
Sbjct: 874 CDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIK 933
Query: 975 GVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKV-EAADHQGIVPAVYVRR 1033
+ +++ E+T+ K D L ++ ++ WKV ++ +VP+V
Sbjct: 934 AICDYRQI------------EITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVC--- 978
Query: 1034 LAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGD 1093
F + P + E ++ R IE QY+++L E + + L E
Sbjct: 979 -----FTVPPPNK--EAVDLANR---IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDR 1028
Query: 1094 M-LEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTP 1152
+ + K G + LQ +F++F +D ++ +F G
Sbjct: 1029 IRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQ-------------VFSG---S 1072
Query: 1153 EGAQIRQELNSRWGSLQRL-----ADEQRQLLGSAHAVEV--FHREADDTKEQIEKKCQA 1205
+ Q+ +E+N Q L +EQ + + + + EV ++ ++++ ++ +
Sbjct: 1073 DITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 1132
Query: 1206 -LSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQK 1264
L D +F + ++ + ER LG TI + E S++ A+ + +
Sbjct: 1133 PLERDDLHESVFRITEQEKLKKELERLKDDLG---TITNKCEEFFSQA--AASSSVPTLR 1187
Query: 1265 MELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQE-LAEDLTG 1323
ELN +++ +++ + L L + + + + +E + D
Sbjct: 1188 SELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNN 1247
Query: 1324 IEILLERHQEHRADMEAEAPTFQALED---FSAELIDSGHHASPEIEKKLQAVKLERDDL 1380
IE L+ ++ R++++ + F ALED + + D E + K + D L
Sbjct: 1248 IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 1307
Query: 1381 EKAWEKRKKILDQCL--------ELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEAL 1432
+ W+ +D L L+ ++ ++ W+ E + R ++ ++ + L
Sbjct: 1308 VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTL 1367
Query: 1433 ---MKKRDDLDKAITAQEGKITDLEHFAESLIAD-EHYAKEEIATRLQRVLDRWKALKAQ 1488
+ ++ L I ++ K+ + + +AE A + Y + + R + +K +
Sbjct: 1368 ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR 1427
Query: 1489 LIDERTKL--GDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAH 1546
+ L ++ +L+ Y L L + + ++ +++ + +H A
Sbjct: 1428 RMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAK 1487
Query: 1547 E----VDGRSEQVHGVINLGNSLIECSACDGNE-EAMKEQLEQLKEHWDHLLERTNDKGK 1601
E V S+ + G E KEQL + + L + DK
Sbjct: 1488 ELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMT 1547
Query: 1602 KLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLARED 1661
+++ T + SE+ L + D+ ++ + Q +E L
Sbjct: 1548 DEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKL---Q 1604
Query: 1662 ALKDLNTLAED---------LLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEA 1712
+ DL T E+ ++ GT + + K++ + K ++Q A A E +K
Sbjct: 1605 GICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQK---DMQGSAQALAEVVK-- 1659
Query: 1713 YALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNV 1772
+ E++++E ++S +D Q + K ++L + + + V
Sbjct: 1660 -----------NTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKV 1708
Query: 1773 LDMA--EKLKDKAAVGQ-EEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829
+ A E+ + AAV Q EE + ++ ++ + + ++ G K ++ +E
Sbjct: 1709 VTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEG 1768
Query: 1830 EEEAWINEKNAL-------AVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQG 1882
+ ++ I E++ + V G G T K +A +++ + + + + Q
Sbjct: 1769 DGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA-QHEKIISQHQAVIIATQS 1827
Query: 1883 EDIL----NKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKAD 1938
+L + L E + K + E +LA++ KL ++F+
Sbjct: 1828 AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYT 1887
Query: 1939 VVEAWIADKETSLKTNGNGA-DLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLIS 1997
E W+ E L+ GA D+ +T L +Q +SF ++ + DL+ IS
Sbjct: 1888 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQ-------KSFSEDVISHKGDLRYITIS 1940
Query: 1998 AQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNN 2057
+ E + KR ++ SA HR E Q L A D F K + L N
Sbjct: 1941 GNR-----VLEAAKSCSKRDGGKVDTSATHR----EVQRKLDHATDRFRSLYSKCNVLGN 1991
Query: 2058 ------------------------WCE-KMEENLSEPVHCVSLNEIRQLQ--KDHEDFLA 2090
CE ++LSEP+ N RQL+ K + ++
Sbjct: 1992 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQIS 2051
Query: 2091 SLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEA 2150
S A K E+ + +P+ T++ + ++ LS + ER ++LQ
Sbjct: 2052 SQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLT 2111
Query: 2151 RQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEAN-KRKQKEIQAM 2209
R + + E + E L+ + L++ + LE + +Q I AM
Sbjct: 2112 RSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAM 2171
Query: 2210 KRQLTKIVDLGDNLEDALI------LDIKYSTIG------------LAQQWDQLYQLGLR 2251
++ K ++ D + + L ++S L + + L +
Sbjct: 2172 NEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEK 2231
Query: 2252 MQHNLEQQIQA---KDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLP 2308
+Q LE + QA D+ G K+ + + ++ E+ + L HK+ L L
Sbjct: 2232 LQTFLETKTQALTEVDVPG------KDVTELSQYMQESTSEFLEHKKHLEVLHSL----- 2280
Query: 2309 MVEEDEHEPKFEK--FLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALAE 2366
+ E H +K L+ + K + +ED I ++ E + S E +AFQ L +
Sbjct: 2281 LKEISSHGLPSDKALVLEKTNNLSKKFKEMED----TIKEKKEAVTSCQEQLDAFQVLVK 2336
Query: 2367 GKSYITKEDMKQ 2378
KE K+
Sbjct: 2337 SLKSWIKETTKK 2348
Score = 69.7 bits (169), Expect = 3e-11
Identities = 423/2395 (17%), Positives = 896/2395 (37%), Gaps = 430/2395 (17%)
Query: 68 WIMEKVN--ILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSA 125
W+ EK + D S E TNI K H L E+ K + +++ E+ H A
Sbjct: 754 WLNEKEEEEVAYDWS-ERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPA 812
Query: 126 HEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGD-KEA----- 179
+A+ ++ W +L+L +Q+++E E+ D KEA
Sbjct: 813 RLTIEAYRAAMQTQWSWILQL----------CQCVEQHIKENTAYFEFFNDAKEATDYLR 862
Query: 180 -IATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSK 238
+ +++ +R+ +HK + Q + KE E+ QY + A +IQ K
Sbjct: 863 NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKE----ELLQYKSTIANLMGKAKTIIQLK 918
Query: 239 QNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVA 298
+ + + KA+ + ++ I K+ E VL +
Sbjct: 919 PRNSDCPLKTSIPI-----KAICDYRQIE---------ITIYKDDECVLAN--------- 955
Query: 299 SEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRAL 358
+SH+ + ++ ++ A + + P + ++ + ++++ L
Sbjct: 956 -----NSHRAKWKVISPTGNE-----AMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL 1005
Query: 359 ATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHE 418
+ +++ +H ++ D + A N + T + G +H+
Sbjct: 1006 WHESHINMKSVVSWHYLINEIDRI--------RASNVASIKTMLPG---------EHQQV 1048
Query: 419 IDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDF 478
+ + RF+ E Q+ + ++ +++ + + LL+ ER Q E +
Sbjct: 1049 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKS-AEREEQEESVYNL 1107
Query: 479 HLF------YRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKI 532
++ R D + + LE +DL S+ + + E ++ ++ +
Sbjct: 1108 YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESV----FRITEQEKLKKELERLKDDL 1163
Query: 533 ITVDKTATKLIGDDHYDSE--NIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYED 590
T+ + S +++ + +L + + ++T LK L+ K +
Sbjct: 1164 GTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA 1223
Query: 591 SDDLKNWINKKKKLADDE----DYKDIQNLKSRV--------QKQQVF---EKELAVNKT 635
++ L + KL ++E D +I+NL S + +K+QVF E EL K
Sbjct: 1224 AEALVKLY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKA 1281
Query: 636 QLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FEN 694
+ + KT +E D + ++ W+ + + L + L+ + +
Sbjct: 1282 ISDEMFKTYKER----DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRD 1337
Query: 695 NAEDLQRWLEDVE--WQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAY 752
L W++ VE + E+ + + +L + +L S + +Q ++D A
Sbjct: 1338 TYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ 1397
Query: 753 FEEI----------------GHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQ 796
+ S R R +S L TR L+ L+
Sbjct: 1398 YSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQY 1457
Query: 797 LICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERG 856
+ + D ++E E S K+ + + + + + +++ +++ + G
Sbjct: 1458 I--KFAGDSLKRLEEEEKSLEE--------EKKEHVEKAKELQKWVSNISKTLKDAEKAG 1507
Query: 857 NKMVEEGHFAAEDVASRVKSLNQNMESLRARAAR--------RQNDLEA---------NV 899
+ ++E+++++ + L++ +++++ A+ +N+LE N+
Sbjct: 1508 KPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNL 1567
Query: 900 QFQQYLADLHEAETW--IREKEPIVDNTNYGADEEAAG----------ALLKKHEAFLLD 947
F + L L E++T ++ +E IV E+ G L+ EAF++
Sbjct: 1568 LFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI- 1626
Query: 948 LNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLL 1007
GD L+ Q +Q + + G + +A EV + L
Sbjct: 1627 ----GDGTVELKKY----QSKQEELQKDMQGSAQALA----------EVVKNTENFL--- 1665
Query: 1008 SSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSL 1067
++ K+ D I + ++ ++ + ++ ++E + + E + +
Sbjct: 1666 ---KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA 1722
Query: 1068 LDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQ--EKKAENTGVELDDVWELQKKFDEFQK 1125
+ + EE + ++ ++L+W+ +K +E G + V +++ FQ+
Sbjct: 1723 VKQLEESKTKI-------------ENLLDWLSNVDKDSERAGTKHKQV--IEQNGTHFQE 1767
Query: 1126 DLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAV 1185
+ + + ++V +LL E + + ++ LN ++ Q++ + +++ AV
Sbjct: 1768 --GDGKSAIGEEDEVNGNLL-ETDVDGQVGTTQENLNQQY---QKVKAQHEKIISQHQAV 1821
Query: 1186 EVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGET 1245
+ + A + +EK+ Q LS + +++ L+ +E L K+ +
Sbjct: 1822 IIATQSA---QVLLEKQGQYLSPEEKEKLQKNMKELKVH---YETALAESEKKMKLTHSL 1875
Query: 1246 AERLSESHPDATED---LQRQKMELNE---AWEDLQG------RTKDRKESL--NEAQKF 1291
E L + D TE LQ+ + EL +D+ G R K E + ++
Sbjct: 1876 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1935
Query: 1292 YLFLSKARDLQ---NWISSIGGMVSSQELAEDLTGIEILLERHQEHRAD-MEAEAPTFQA 1347
Y+ +S R L+ + GG V D + ++R +H D +
Sbjct: 1936 YITISGNRVLEAAKSCSKRDGGKV-------DTSATHREVQRKLDHATDRFRSLYSKCNV 1988
Query: 1348 LEDFSAELIDSGHH---ASPEIEKKLQAVK--LERDDLEKAWEKRKKILDQCLELQMFQG 1402
L + +L+D H AS + LQA + + E K + Q E + QG
Sbjct: 1989 LGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQG 2048
Query: 1403 NCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIA 1462
Q+ S VA E L+ + LD+ +L+ ++D+ K + G+ DL S
Sbjct: 2049 ---QISSQQVAVE-KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDL-----SKSV 2099
Query: 1463 DEHYAKEEIA-TRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLP 1521
+E K +I TR V D L+E+ +W+ +
Sbjct: 2100 NERNEKLQITLTRSLSVQD---------------------------GLDEMLDWMGNVES 2132
Query: 1522 TACDESY--KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMK 1579
+ ++ ++T +Q K+ ++ GR ++ AM
Sbjct: 2133 SLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSIN--------------------AMN 2172
Query: 1580 EQLEQLKEHWD-----HLLERTNDKGKKLNEAS--------RQQRFNTSIRDFEFWLSEA 1626
E++++ E D L + D + +EAS + + T + FE +
Sbjct: 2173 EKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKL 2232
Query: 1627 ETLLAMKDQA--------RDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGT 1678
+T L K QA +D+ +++ E L + L+ L++L +++ S G
Sbjct: 2233 QTFLETKTQALTEVDVPGKDVTELSQYMQES---TSEFLEHKKHLEVLHSLLKEISSHGL 2289
Query: 1679 FNVDQIV-KKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDL-DDEESWIEEKLIRV 1736
+ +V +K +N++K+F +++ E + FQ L +SWI+E +V
Sbjct: 2290 PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV 2349
Query: 1737 SSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL-----------KDKAAV 1785
+ + L+ K+L+ + P IQ V + L K AAV
Sbjct: 2350 PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAV 2409
Query: 1786 -----------------------GQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYL 1822
G I+ + +E L L K + +L L L
Sbjct: 2410 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL 2469
Query: 1823 QFMQNAEEEEA----WINEKNALAVRGDCGDTLAATQSLLMKHEALEN-DFAVHETRVQN 1877
Q A+EE + W+ + N A + T A T + +K + +N F + N
Sbjct: 2470 ---QKAQEESSAMMQWLQKMNKTATKWQ--QTPAPTDTEAVKTQVEQNKSFEAELKQNVN 2524
Query: 1878 VCAQGEDILNKVLQEESQN----------KEISSKIEALNEKTPSLAKAIAAWKLQLEDD 1927
+ +D L ++L+E EI SK + LN+ T + + E
Sbjct: 2525 KVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE------ESS 2578
Query: 1928 YAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSF--QQERL 1985
+F ++ W+ +KE + G + + L +Q + LQ F ++ +
Sbjct: 2579 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQ--VQILLQEFATRKPQY 2636
Query: 1986 PEITDLKDKLISAQHNQSK---AIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE 2042
++T ++S ++E+ AA+ ++W+ L + + + + + +
Sbjct: 2637 EQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQ 2696
Query: 2043 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLN-EIRQLQKDHEDFLASLARAQADFKC 2101
L + K S L+N K+ +L+ H ++N ++ QK ++ + + + K
Sbjct: 2697 SLLRSLSDKLSDLDN---KLSSSLAVSTHPDAMNQQLETAQKMKQE----IQQEKKQIKV 2749
Query: 2102 LLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQE 2161
L + + AL L+ + LE K D+ ++ E +Q ++ + +
Sbjct: 2750 AQALCEDLSALVKEEYLKAELSRQ-LEGILKSFKDVEQKAENHVQHLQSACASS----HQ 2804
Query: 2162 FEQNASTFLQWILETRAYFLDGS--LLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDL 2219
F+Q + F W L+T+ + S + + LES ++ +K K + A K +
Sbjct: 2805 FQQMSRDFQAW-LDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE 2863
Query: 2220 GDNL------EDALILDIKYSTIGLAQQWD----QLYQLGLRMQHNLEQQIQAKD 2264
G+NL + L ++ +TI WD Q+ + +++ +LE+ ++ K+
Sbjct: 2864 GENLLLKTQGSEKAALQLQLNTI--KTNWDTFNKQVKERENKLKESLEKALKYKE 2916
Score = 41.2 bits (95), Expect = 0.012
Identities = 42/210 (20%), Positives = 92/210 (43%), Gaps = 23/210 (10%)
Query: 574 RRRLLKESLLLQKLYEDS------DDLKNWINKKKKLADDEDY-KDIQNLKSRVQKQQ-- 624
R+ LLK SLL Q L E+ DL NW+++ + D ++ D+ +++S ++ +
Sbjct: 625 RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNV 684
Query: 625 ---VFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGT 681
+ E E ++ + ++ IQ T + YA +L + S + +LL ++ +
Sbjct: 685 HRAIEEFESSLKEAKISEIQMTAPLKLT---YAE-----KLHRLESQYAKLLNTSRNQER 736
Query: 682 QLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQD 741
L + F + A + WL + E + + D+ + + + H L + +++
Sbjct: 737 HLDTLH---NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 793
Query: 742 QVDILTDLAAYFEEIGHPDSKDIRARQESL 771
+ + ++A HP I A + ++
Sbjct: 794 NIKSVQEIAEQLLLENHPARLTIEAYRAAM 823
Score = 40.8 bits (94), Expect = 0.016
Identities = 60/342 (17%), Positives = 134/342 (39%), Gaps = 53/342 (15%)
Query: 1707 EKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHE 1766
+ L E +F QDL +W++E +++ ++G DL V++ L+ HK + + E
Sbjct: 636 QNLTEEEINMKFVQDL---LNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFE 692
Query: 1767 PAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKL------EESLE 1820
+++ K+ EIQ+ + + EKL L L E L+
Sbjct: 693 SSLKEA-----KI--------SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLD 739
Query: 1821 YL-QFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVC 1879
L F+ A E W+NEK + E + D++ T +
Sbjct: 740 TLHNFVSRATNELIWLNEK---------------------EEEEVAYDWSERNTNIARKK 778
Query: 1880 AQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADV 1939
+++ ++ Q+E K + E L + I A++ ++ +++
Sbjct: 779 DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSW--ILQLCQC 836
Query: 1940 VEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQ 1999
VE I + + + + D+L ++ DA + + +R I L+D + +
Sbjct: 837 VEQHIKENTAYFEFFNDAKEATDYL-----RNLKDAIQRKYSCDRSSSIHKLEDLVQESM 891
Query: 2000 HNQSKAIEER--YAALLKRWEQLLEASAVHRQKLLEKQLPLQ 2039
+ + ++ + A L+ + + +++ + L+ +P++
Sbjct: 892 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIK 933
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 214 bits (546), Expect = 6e-55
Identities = 443/2242 (19%), Positives = 900/2242 (40%), Gaps = 244/2242 (10%)
Query: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQV-FKRDADDLGKWIMEKVNILTD-KSY 81
+Q + + T + +F ++V ER KL++S + +K + L WI + N L + K
Sbjct: 3017 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 3076
Query: 82 EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHE----ETKAHIE--- 134
DP + K +SL+ E+ ++ L T ++ E E K+ I+
Sbjct: 3077 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 3136
Query: 135 ---ELRHLWDLLLELTLEKGDQLLRALKFQQYVQECA----DILEWIGDK---------- 177
E H LE +K + K + +CA DI + +G +
Sbjct: 3137 MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML 3196
Query: 178 -------EAIATSVELGEDWERTEVLH----KKFED--FQVELVAKEGRVVEVNQYANEC 224
+A+ V+L + + V+ K D QVE +A+E + +Q +E
Sbjct: 3197 QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL--SQQVDEK 3254
Query: 225 AEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKE 284
L I QN + + + + + + ++ ++K+ E
Sbjct: 3255 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLE 3314
Query: 285 PVLTSEDYG----KDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQ 340
++ S D K ++A+E G++R+L +S + +L +A+
Sbjct: 3315 ALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR---------- 3364
Query: 341 IQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPT 400
+E E + E Y KL+ + + + +E G + +T IN
Sbjct: 3365 -EEQVEGTIKRLEEF-------YSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMF 3416
Query: 401 DVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN--ANHEASDEVREKMEILDNNW 458
V K EI+ + Q + GQ L+ A ++ + ++ ++ W
Sbjct: 3417 KVF-----------QKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3465
Query: 459 TALLELWDERHRQYEQCLDFHLFYRDS-EQVDSWMSRQEAFLENEDLGNS-LGSAEALLQ 516
L + +R Q ++ L ++D+ E + SWM E + N+ ++ +A +Q
Sbjct: 3466 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3525
Query: 517 KHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLL--ARRDALREKAATR 574
+ + + ++ + + + K I ++ +K ++ L +R +AL KA TR
Sbjct: 3526 EQKLLQRLLDDRKSTVEVIKREGEK-IATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3584
Query: 575 RRLLKE-SLLLQKLYEDSDDLKNWINK-KKKLADDEDY-KDIQNLKSRVQKQQVFEKELA 631
R L+ S++ Q+ +E + L W+ +K+L + E L+ ++ + + E ++
Sbjct: 3585 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3644
Query: 632 VNKTQLENIQKTGQEM-IEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEA--NQ 688
+ L GQ + + D V ++L + E+ E + + L +A N
Sbjct: 3645 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3704
Query: 689 QLQFENNAEDLQRWLEDVEWQVTS---EDYG-KGLAEVQNRLRKHGLLESAVAARQDQVD 744
++ E+ E L WL +V +++ +DY +GL + Q+ LR +L+ + R+ VD
Sbjct: 3705 KIFGEDEVE-LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR---VLQEDILLRKQNVD 3760
Query: 745 --ILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT 802
+L L + G + I+ + E++ R++ + + K L L L T
Sbjct: 3761 QALLNGLELLKQTTGD-EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHST 3819
Query: 803 EDEEA-WIQETEPSATS--TYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKM 859
+E W+ + E S T + K AS+ + R + + + +++ + + E + +
Sbjct: 3820 HEELCTWLDKVEVELLSYETQVLKGEEASQAQM-RPKELKKEAKNNKALLDSLNEVSSAL 3878
Query: 860 VEEGHFAA-EDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAE-TWIRE 917
+E + A E + V N+ + ++ +++A + Q +AE +WI E
Sbjct: 3879 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITE 3938
Query: 918 KEP-IVDNTNYGADEEAAGALLKKHEAFLLDL----NSFGDSMKALRNQANACQQQQAAP 972
E ++ + +++ A L+ + F +++ + D +K+ AC +++
Sbjct: 3939 TEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQS 3998
Query: 973 VEGVAGEQRVMALYDF--QARSPREVTMKKGDVLTLLSSINKDWWKVEA-----ADHQGI 1025
++ +V+ YD Q S R + +++ L +N+ W E + Q I
Sbjct: 3999 MKKKL--DKVLKNYDTICQINSERYLQLERAQSL-----VNQFWETYEELWPWLTETQSI 4051
Query: 1026 VPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRS---LLDRAEERRRRLLQRY 1082
+ + L ++ + R+ I + + I+ ++ LL+ + + ++Y
Sbjct: 4052 ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKY 4111
Query: 1083 NEFLLAYEAGDMLEWIQEKKAENTGVELDDV----WELQKKFDEFQKDLNTNEPRLRDIN 1138
A D L ++ + V LD+ + K D+ + L RLR
Sbjct: 4112 -------VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPP 4164
Query: 1139 KVADDL--LFEGLLTPEGAQIRQE-LNSRWGSLQRLADEQRQLLG------SAHAVE--- 1186
++ ++ + E + + + E L + +L++ +E G SA AV+
Sbjct: 4165 SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKL 4224
Query: 1187 -------------VFHREAD--DTKEQIEKK-CQALSAA--------------DPGSDLF 1216
V REA D E EK C +S DPG D
Sbjct: 4225 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 4284
Query: 1217 SVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKM-ELNEAWEDLQ 1275
V+ Q E ++ L +++ I+ L + + + + ++ + ELN AW+ L
Sbjct: 4285 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLN 4344
Query: 1276 GRTKDRKESLNEA-QKFYLFLSKARDLQNWISSIGGMVSSQE-LAEDLTGIEILLERHQE 1333
KDR + L EA Q + + + +W+ GG ++S + DL ++ +E ++
Sbjct: 4345 KAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQ 4404
Query: 1334 HRADMEAEAPTFQALEDFSAELI------DSGHHASPEIEKKLQAVKLERDDLEKAWEKR 1387
+++ + + L + AEL+ +S H ++ L +KL D LE+ R
Sbjct: 4405 FKSEAYQQQIEMERL-NHQAELLLKKVTEESDKHT---VQDPLMELKLIWDSLEERIINR 4460
Query: 1388 K-KILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLD--SLEALMKKRDDLDKAIT 1444
+ K+ L L FQ D++ +W+ E L D ++E + K L +
Sbjct: 4461 QHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVL 4520
Query: 1445 AQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLD----RWKALKAQLIDERTKL-GDY 1499
A + + + LI E A EE A+ LQ L+ RW+ + + + +L G
Sbjct: 4521 AHQSTVEAVNKAGNDLI--ESSAGEE-ASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4577
Query: 1500 ANLKQFYRDLEELEEWISE----MLPT----ACDESYKDATNIQRKYLKHQTFAHEVDGR 1551
K F+ ++E+L++W+++ +L + E+ K+ N+ H + +
Sbjct: 4578 RQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV------HMEVCAAFEAK 4631
Query: 1552 SEQVHGVINLGNSLIECSACDGNEEAMKEQ-LEQLKEHWDHLLERTNDKGKKLNEA-SRQ 1609
E ++ G ++ + C + E +Q + LKE W+ + + N++ KL EA +
Sbjct: 4632 EETYKSLMQKGQQML--ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLA 4689
Query: 1610 QRFNTSIRDFEFWLSEAE-TLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNT 1668
F+ S++DF WL++AE TL + L + + +H++ E+ + + + +L+
Sbjct: 4690 MEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDK 4749
Query: 1669 LAEDL-LSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF-QFFQDLDDEE 1726
L S +V I +V R+ V + L +A QF +
Sbjct: 4750 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4809
Query: 1727 SWIEEKLIRVSSQ-DYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAV 1785
W+EE + S+ + D ++ L +HK + L A LK+K ++
Sbjct: 4810 EWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4869
Query: 1786 GQEEIQL--RLAQFVEHWEKLKELAKARGLKLEESLEYL-QFMQNAEEEEAWINE-KNAL 1841
+ ++L L++ + W+ + + R KLEE+L + QF + W+ + L
Sbjct: 4870 ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4929
Query: 1842 AVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEES----QNK 1897
A + +L+ H+A + + + VQ + +++ + S Q +
Sbjct: 4930 AEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQ 4989
Query: 1898 EISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNG 1957
E+S++ E + + S + A Q E EF+ + W+A+ E +L+ +G
Sbjct: 4990 ELSTRWETVCALSISKQTRLEAALRQAE------EFHSVVHALLEWLAEAEQTLRFHGVL 5043
Query: 1958 ADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLK-R 2016
D D L L Q ++ L + T + D +++ H S + + +++ R
Sbjct: 5044 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 5103
Query: 2017 WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLN 2076
+E++L + H+Q+L L ++L A W E + + V +
Sbjct: 5104 FEEVLAWAKQHQQRLASALAGLIAKQELLEALL----AWLQWAETTLTDKDKEVIPQEIE 5159
Query: 2077 EIRQLQKDHEDFLASLARAQAD 2098
E++ L +H+ F+ + R Q D
Sbjct: 5160 EVKALIAEHQTFMEEMTRKQPD 5181
Score = 194 bits (493), Expect = 9e-49
Identities = 436/2211 (19%), Positives = 894/2211 (40%), Gaps = 271/2211 (12%)
Query: 56 QVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTR 115
++ K D K +++KV+++T++ + ++ QK + + + R + ++
Sbjct: 3118 EIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQL 3177
Query: 116 EERFTMGHSAH--------EETKAHIEELRH--------LWDLLLELTLEKGDQLLRALK 159
+ ++G A+ + + ++ L+H DL++E + KG + L+
Sbjct: 3178 DIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDV-LLQ 3236
Query: 160 FQQYVQECADILEWIGDK-EAIATSVE-LGEDWERTEVLHKKFEDFQVEL--VAKEGRVV 215
+ QE + + + + +K + T ++ +G + +F +F EL +A GR
Sbjct: 3237 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3296
Query: 216 EVNQYANE---------------------------CAEENHPDLPLIQSKQNEVNAAWER 248
E Q E EE PDL I+ ++ +
Sbjct: 3297 ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK 3356
Query: 249 LRGLALQRQKALSNA--------ANLQRFKRDVTEAIQWIKEKEPV-LTSEDYGKDL--- 296
L A R++ + + L+ F + +A + + + PV + +E + L
Sbjct: 3357 LLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMF 3416
Query: 297 -VASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLT-LSHPSDAPQIQEMKEDLVSSWEH 354
V + +G ++++ + + + AK+ L H D D+ + W+
Sbjct: 3417 KVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD---------DVNARWKT 3467
Query: 355 IRALATSRYEKLQATYWY-HRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQ 413
+ R +LQ + RF + L WM + T + A++ P A +V+ + Q
Sbjct: 3468 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD-TEELVANQKPPS-AEFKVVKAQIQ 3525
Query: 414 QHKHEIDSYDDRFQSADETGQD--LVNANHEASDEVR--EKMEILDNNWTALLELWDERH 469
+ K DDR + + ++ + E +D+V+ +++ +LD+ W ALL + R+
Sbjct: 3526 EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN 3585
Query: 470 RQYEQC-LDFHLFYRDSEQVDSWMSRQEAFLEN-EDLGNSLGSAEALLQKHEDFEEAFTA 527
RQ E + F+ E ++ W++ E L N E +G E + +H+ E+
Sbjct: 3586 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3645
Query: 528 QEEKIITVDKTATKL-IGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQK 586
+ + L + D + +++ D ++EK+ +R LL+++L K
Sbjct: 3646 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3705
Query: 587 LY-EDSDDLKNWINK---KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQK 642
++ ED +L NW+N+ K +DY + L + + +V ++++ + K ++
Sbjct: 3706 IFGEDEVELMNWLNEVHDKLSKLSVQDYST-EGLWKQQSELRVLQEDILLRKQNVDQALL 3764
Query: 643 TGQEMIEGGHYASDNVTT---RLSEVASLWEELLEATKQKGTQLHEANQQLQ-FENNAED 698
G E+++ D V +L + + ++++ + + L +A Q + + E+
Sbjct: 3765 NGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEE 3822
Query: 699 LQRWLEDVEWQVTSEDYG--KGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEI 756
L WL+ VE ++ S + KG Q ++R L + A + +D L ++++ E+
Sbjct: 3823 LCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA-KNNKALLDSLNEVSSALLEL 3881
Query: 757 GHPDSKDIRARQ--ESLVC----RFEALKEPLATRKKKLLD--LLHLQLICRDTEDEEAW 808
RAR+ E +V R+ + + + T+K + +D +L Q + + E +W
Sbjct: 3882 -----VPWRAREGLEKMVAEDNERYRLVSDTI-TQKVEEIDAAILRSQQFDQAADAELSW 3935
Query: 809 IQETEPSATST---YLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHF 865
I ETE S L +D +++ L + I H+ I ++ + G+K++
Sbjct: 3936 ITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDIIDDLVKSGHKIMTA--C 3991
Query: 866 AAEDVASRVKSLNQ---NMESLRARAARRQNDLE-ANVQFQQYLADLHEAETWIREKEPI 921
+ E+ S K L++ N +++ + R LE A Q+ E W+ E + I
Sbjct: 3992 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI 4051
Query: 922 VDNTNYGA-----------DEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQA 970
+ A + L+ +H+ + +N G + L
Sbjct: 4052 ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL------------ 4099
Query: 971 APVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAA--DHQGIVPA 1028
+P EG + +++ +A ++ +V + + +S + K++ + IV
Sbjct: 4100 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4159
Query: 1029 VYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRL--LQRYNEFL 1086
+ E + ++ E N++ E+++ Y +L R EE R +
Sbjct: 4160 LRQPPSISAEVEKIKEQISENK-NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 4218
Query: 1087 LAYEAGDMLEWIQEK---KAENTGVELDDVWELQKKF--------------DEFQKDLN- 1128
+ D + +I E E +L DV EL +KF +F +DL
Sbjct: 4219 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED 4278
Query: 1129 -------------TNEPRLRDINKVADDL---------LFEGLLTPEGAQIRQ---ELNS 1163
E +I+ + ++L L P+ +++ ELNS
Sbjct: 4279 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4338
Query: 1164 RWGSLQRLADEQRQLLGSAHAVEVFHREA-DDTKEQIEKKCQALSAADP-GSDLFSVQAL 1221
W SL + ++ L A V +++ + ++ L++ P G+DL +V+
Sbjct: 4339 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4398
Query: 1222 QRRHEGFERDLVPLGDKVTILGETAERLSESHPDATED--LQRQKMELNEAWEDLQGRTK 1279
+ F+ + ++ L AE L + + ++ +Q MEL W+ L+ R
Sbjct: 4399 IEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERII 4458
Query: 1280 DRKESLNEAQKFYLFLSKARD-LQNWISSIGGMVSSQE-LAEDLTGIEILLERHQEHRAD 1337
+R+ L A A D L W++ G++S Q+ + D IEI L +H + D
Sbjct: 4459 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQND 4518
Query: 1338 MEAEAPTFQALEDFSAELIDS--GHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCL 1395
+ A T +A+ +LI+S G AS ++ KL+ + ++ + E+RK+ LD L
Sbjct: 4519 VLAHQSTVEAVNKAGNDLIESSAGEEAS-NLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4577
Query: 1396 -ELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDK----AITAQEGKI 1450
+ + F G + ++ W+ E L + L L K++ ++ A A+E
Sbjct: 4578 RQAKGFHGEIEDLQQWLTDTERHLLAS--KPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4635
Query: 1451 TDLEHFAESLIAD-EHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLK-QFYRD 1508
L + ++A A+ I + + ++W++++ +L + +TKL + NL +F+
Sbjct: 4636 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4695
Query: 1509 LEELEEWISEMLPTACDESYKDAT--NIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLI 1566
L++ W+++ T S + + +H+ FA+EV+ EQ+ + G L
Sbjct: 4696 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4755
Query: 1567 ECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEA-SRQQRFNTSIRDFEFWLSE 1625
S + +K L ++ W+ +++R ++G+ L++A R ++F+ + WL E
Sbjct: 4756 YFSQKQ-DVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEE 4814
Query: 1626 AETLLAMK-DQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQI 1684
+E L + + A D L +H+ ++ + A+ N L T D
Sbjct: 4815 SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEK-TSLADDN 4873
Query: 1685 VKKKDNVNK---RFLNVQELAAAHHEKLKEAYALF-QFFQDLDDEESW---IEEKLIRVS 1737
+K D +++ ++ + + KL+EA QF L W +E +L
Sbjct: 4874 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL--AE 4931
Query: 1738 SQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQF 1797
Q D+ V NL+ HK + EL ++Q + A +L + + +++++ +
Sbjct: 4932 DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQEL 4991
Query: 1798 VEHWEKLKELAKARGLKLEESLEYL-QFMQNAEEEEAWINE-KNALAVRGDCGDTLAATQ 1855
WE + L+ ++ +LE +L +F W+ E + L G D A +
Sbjct: 4992 STRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALR 5051
Query: 1856 SLLMKHEALENDFAVHETRVQNVCAQGEDIL----------------------NKVLQEE 1893
+L+ +H+ + G+ +L +VL
Sbjct: 5052 TLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWA 5111
Query: 1894 SQNKE-ISSKIEALNEKTPSLAKAIAAWKLQLE---DDYAFQEFNWKADVVEAWIADKET 1949
Q+++ ++S + L K L +A+ AW E D + + + V+A IA+ +T
Sbjct: 5112 KQHQQRLASALAGLIAK-QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQT 5170
Query: 1950 SLKTNGNGADLGDFLTLLAKQDTLD-ASLQSF---------QQERLPEITDLKDKLISAQ 1999
++ D +T K+ D +SLQS ++R P S
Sbjct: 5171 FMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFP----ASSLYPSGS 5226
Query: 2000 HNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAH 2050
Q + R L+ +W+Q+ + R+KL + L + E+L EFA+
Sbjct: 5227 QTQIETKNPRVNLLVSKWQQVWLLALERRRKLND---ALDRLEEL-REFAN 5273
Score = 156 bits (395), Expect = 2e-37
Identities = 445/2411 (18%), Positives = 946/2411 (39%), Gaps = 288/2411 (11%)
Query: 39 KERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTN-----IQGKYQK 93
K+++AE KL LQ + ++ + +W+ +K+N K + P ++ + ++
Sbjct: 2594 KDKIAELNTKLSK---LQKAQEESSAMMQWL-QKMNKTATKWQQTPAPTDTEAVKTQVEQ 2649
Query: 94 HQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEET--KAHIEELRHLWDLLLELTLEKG 151
++S EAE++ + EL+ E E K + E+ W L +LT+++
Sbjct: 2650 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2709
Query: 152 DQLLRALK-FQQYVQECADILEWIGDKEAIATSV-ELGEDWERTEVLHKKFEDFQVELVA 209
+L + Q+ A + +W+ +KE + + + L D ++ + E
Sbjct: 2710 QKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFAT 2769
Query: 210 KEGRVVEVNQYANECAEENHPDLPL---IQSKQNEVNAAWERLRGLALQR----QKALSN 262
++ + ++ D L ++ + V W+ L G R +A+
Sbjct: 2770 RKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK 2829
Query: 263 AANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKE 322
+ Q R +++ + + K + D + + + + +++ + ++K
Sbjct: 2830 STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQ--LETAQKMKQEIQQEKKQIKV 2887
Query: 323 LCAKAEKLTLSHPSD--APQIQEMKEDLVSSWEHIRALATSRYEKLQ-ATYWYHRFSSDF 379
A E L+ + ++ E ++ S++ + A + + LQ A H+F
Sbjct: 2888 AQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2947
Query: 380 DELSGWMNEKTAAINADE-LPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN 438
+ W++ K N + + E L+ H+ + + ++ G++L+
Sbjct: 2948 RDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL- 3006
Query: 439 ANHEASDEVREKMEI--LDNNWTALLELWDERHRQYEQCLDFHLFYRDS-EQVDSWMSRQ 495
+ S++ ++++ + NW + ER + ++ L+ L Y++ E + W+ +
Sbjct: 3007 LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 3066
Query: 496 EAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555
+ LE E + K + ++ + ++ TA L+ D E +
Sbjct: 3067 QNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 3126
Query: 556 IRDGLLARRDALREKAATRRRLLKESLLLQKLYED-SDDLKNWINKKKKLADDEDYKDIQ 614
L+ + D + E+ +++ L+ K +++ S + K + K+ D D Q
Sbjct: 3127 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQ 3186
Query: 615 NLKSR-VQKQQVFEKELAVNKTQLENIQKTGQEMI--EGGHYASDNVTTRLSEVASLWEE 671
++ + Q +K L K Q++ ++ Q+++ + +V ++ +A
Sbjct: 3187 AYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHST 3246
Query: 672 LLEATKQKGTQLHEANQQL-QFENNAEDLQRWLEDVEWQVTS--------EDYGKGLAEV 722
L + +K + L Q + F+N ++ + + ++ S E K +
Sbjct: 3247 LSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETI 3306
Query: 723 QNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPL 782
+ L+K LE A+ A D + + EE PD I+ E+L + L +
Sbjct: 3307 KAFLKK---LE-ALMASNDNANKTCKMMLATEETS-PDLVGIKRDLEALSKQCNKLLDRA 3361
Query: 783 ATRKKKLLDLL-HLQLICRDTEDEEAWIQETEPSATSTY-LGKDLIASKKLLNRHRVIL- 839
R++++ + L+ ++ +Q+ E S +G + + LN +V
Sbjct: 3362 QAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQK 3421
Query: 840 ENIASHEPRIQEITERGNKMVEEGHFAA---------EDVASRVKSLNQNMESLRAR--- 887
E I + + Q++ G +++ + +DV +R K+LN+ + A+
Sbjct: 3422 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3481
Query: 888 ----AARRQNDLEA------------------NVQFQQYLADLHEAETWIR---EKEPIV 922
R Q+ LE+ + +F+ A + E + R +++ V
Sbjct: 3482 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV 3541
Query: 923 DNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRV 982
+ ++ A A L L+ +AL N+A +Q +EG++ V
Sbjct: 3542 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQ----LEGIS----V 3593
Query: 983 MALYDFQARSPRE---VTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEF 1039
+A + P T++K V + + A H+ + + +
Sbjct: 3594 VAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQA 3653
Query: 1040 PMLPQR-----RREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRY-NEFLLAYEAGD 1093
+ Q RE+ + + + + Y + +++ R L Q N + + +
Sbjct: 3654 VSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVE 3713
Query: 1094 MLEWIQEKKAENTGVELDD-----VWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEG 1148
++ W+ E + + + + D +W+ Q + Q+D+ LR N D L G
Sbjct: 3714 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI-----LLRKQN--VDQALLNG 3766
Query: 1149 L-----LTPEGAQIRQE----LNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQI 1199
L T + I Q+ + +R+ + +L+ + + L A + R T E++
Sbjct: 3767 LELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA---RRLHSTHEEL 3823
Query: 1200 EKKCQALSAADPGSDLFSVQAL--------QRRHEGFERDLVPLGDKVTILGETAERLSE 1251
C L + + Q L Q R + +++ + L E + L E
Sbjct: 3824 ---CTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE 3880
Query: 1252 SHP-DATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQ-NWISSIG 1309
P A E L++ E NE + + + E ++ A +A D + +WI+
Sbjct: 3881 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWIT--- 3937
Query: 1310 GMVSSQELAEDLTGI-EILLERHQEHRADMEAEAPTFQAL--EDFSAELIDSGHH---AS 1363
E + L + +I LE+ Q + T + L +D +L+ SGH A
Sbjct: 3938 ------ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3991
Query: 1364 PEIEKKLQAVKLER-----DDLEKAWEKRKKILDQCLEL-QMFQGNCDQVESWMVAREN- 1416
E EK+ KL++ D + + +R L++ L F +++ W+ ++
Sbjct: 3992 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI 4051
Query: 1417 ------------SLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADE 1464
+LR + E + + + +DK + ++ +L I ++
Sbjct: 4052 ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK-MNKTGPQLLELSPGEGFSIQEK 4110
Query: 1465 HYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTAC 1524
+ A + + ++++ + + + I + T+ D + Q LE + E + + +
Sbjct: 4111 YVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILESLERIVERLRQPPSISA 4168
Query: 1525 D-----ESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMK 1579
+ E + N+ K Q + R E++ + G + + SA +A++
Sbjct: 4169 EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM--IARSGGTDKDISA-----KAVQ 4221
Query: 1580 EQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQA--- 1636
++L+Q+ W+++ ++ KL + +FW ++ +KD
Sbjct: 4222 DKLDQMVFIWENIHTLVEEREAKLLDVMELAE--------KFWCDHMSLIVTIKDTQDFI 4273
Query: 1637 RDLASAG---NLLKKHQ----LLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK- 1688
RDL G +++K+ Q + E+ ++ L + L +L+++ IVKK
Sbjct: 4274 RDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSI 4333
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAY-ALFQFFQDLDDEESWIEEKLIRVSSQD-YGRDLQ 1746
D +N + ++ + +KL+EA A Q+ L W++ +++S G DL+
Sbjct: 4334 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4393
Query: 1747 GVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEE--IQLRLAQFVEHWEKL 1804
V+ +++ K+ + E + ++ + AE L K ++ +Q L + W+ L
Sbjct: 4394 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4453
Query: 1805 KELAKARGLKLEESLEYL-QFMQNAEEEEAWINE-KNALAVRGDCGDTLAATQSLLMKHE 1862
+E R KLE +L L QF +E AW+ + L+ + G A + L KH
Sbjct: 4454 EERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH 4513
Query: 1863 ALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKL 1922
L+ND H++ V+ V G D++ EE+ N + +K+E LN++ ++ + K
Sbjct: 4514 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN--LQNKLEVLNQRWQNVLEKTEQRKQ 4571
Query: 1923 QLEDDYAFQE---FNWKADVVEAWIADKETSLKTNGNGADLGD------------FLTLL 1967
QL D A ++ F+ + + ++ W+ D E L + L +
Sbjct: 4572 QL--DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFE 4629
Query: 1968 AKQDTLDASLQSFQQ--ERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASA 2025
AK++T + +Q QQ R P+ SA+ N I++ L ++WE +
Sbjct: 4630 AKEETYKSLMQKGQQMLARCPK---------SAETN----IDQDINNLKEKWESV----- 4671
Query: 2026 VHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDH 2085
KL E++ L++A +L +EF + NW + E+ L+ + + Q D
Sbjct: 4672 --ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDE 4729
Query: 2086 EDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVL----ERTWKHLSDIIEER 2141
A+ + + ++ELD+ L S + ++ L + W+ + + ER
Sbjct: 4730 HKVFANEVNSHRE--QIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVER 4787
Query: 2142 EQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSL--LKETGTLESQLEAN 2199
+ L ++AR + ++F + S ++W LE LD L + +++QL +
Sbjct: 4788 GRSL--DDAR-----KRAKQFHEAWSKLMEW-LEESEKSLDSELEIANDPDKIKTQLAQH 4839
Query: 2200 KRKQKEIQAMK----------RQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLG 2249
K QK + A R L + L D D L LD S L +WD +
Sbjct: 4840 KEFQKSLGAKHSVYDTTNRTGRSLKEKTSLAD---DNLKLDDMLSE--LRDKWDTICGKS 4894
Query: 2250 LRMQHNLEQQI 2260
+ Q+ LE+ +
Sbjct: 4895 VERQNKLEEAL 4905
Score = 130 bits (326), Expect = 2e-29
Identities = 246/1229 (20%), Positives = 521/1229 (42%), Gaps = 154/1229 (12%)
Query: 22 EEIQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIME---KVNILT 77
E +++ E RY+ + + ++ ++++ + Q F + AD WI E K+ L
Sbjct: 3888 EGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLG 3947
Query: 78 DKSYE-DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEET-KAHIEE 135
D E D T+ Q + QK + E+ ++ +L K+ + T +++ K +++
Sbjct: 3948 DIRLEQDQTSAQLQVQK--TFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK 4005
Query: 136 LRHLWDLLLELTLEKGDQLLRALKF-QQYVQECADILEWIGDKEAIATSVELGEDWERTE 194
+ +D + ++ E+ QL RA Q+ + ++ W+ + ++I + +L E
Sbjct: 4006 VLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS--QLPAPALEYE 4063
Query: 195 VLHKKFEDFQV--ELVAK-EGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRG 251
L ++ E+ + EL+A+ + + ++N+ + E + + IQ K + + +++
Sbjct: 4064 TLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 4123
Query: 252 LALQRQKALSNAAN-------------------LQRFKRDVTEAIQWIKEKEPVLTSEDY 292
+R AL A + ++R ++ + + + K KE + +++
Sbjct: 4124 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNV 4183
Query: 293 GKDLVASEGLFHSHKGL-ERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSS 351
D+ + L+ + K E +A K++ AKA +Q+ + +V
Sbjct: 4184 SVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA-------------VQDKLDQMVFI 4230
Query: 352 WEHIRALATSRYEKL-QATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLD 410
WE+I L R KL +F D L + + I E P G + +
Sbjct: 4231 WENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP----GIDPSVV 4286
Query: 411 RHQQH-----KHEIDSYDDRFQSADETGQDLVNANHEASDE-VREKMEILDNNWTALLEL 464
+ QQ + EID + G +L+ A E V++ ++ L++ W +L +
Sbjct: 4287 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4346
Query: 465 WDERHRQYEQCLDFHLFYRDSEQ-VDSWMSRQEAFLEN-EDLGNSLGSAEALLQKHEDFE 522
W +R + E+ + + Y+D Q V W+ L + +G L + + +++ + F+
Sbjct: 4347 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK 4406
Query: 523 EAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARR---DALREKAATRRRLLK 579
Q+ ++ ++ A L+ +S+ ++D L+ + D+L E+ R+ L+
Sbjct: 4407 SEAYQQQIEMERLNHQAELLLKKVTEESDK-HTVQDPLMELKLIWDSLEERIINRQHKLE 4465
Query: 580 ESLLLQKLYEDS-DDLKNWINKKKKLADDEDYK--DIQNLKSRVQKQQVFEKELAVNKTQ 636
+LL ++ + D+L W+ + L ++ D + ++ + K V + ++ +++
Sbjct: 4466 GALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQST 4525
Query: 637 LENIQKTGQEMIEG--GHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FE 693
+E + K G ++IE G AS N+ +L + W+ +LE T+Q+ QL A +Q + F
Sbjct: 4526 VEAVNKAGNDLIESSAGEEAS-NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFH 4584
Query: 694 NNAEDLQRWLEDVEWQVTSEDYGKGLAEV-QNRLRKHGLLESAVAARQDQVDILTDLAAY 752
EDLQ+WL D E + + GL E + +L H + +A A+++ L
Sbjct: 4585 GEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQ 4644
Query: 753 FEEIGHPDSKDIRARQE--SLVCRFEALKEPLATRKKKLLDLLHLQLICRDT-EDEEAWI 809
P S + Q+ +L ++E+++ L RK KL + L+L + ++ +D W+
Sbjct: 4645 MLA-RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWL 4703
Query: 810 QETEPS---ATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERG---------- 856
+ E + A+ L D + + ++ H+V + SH +I E+ + G
Sbjct: 4704 TQAEQTLNVASRPSLILDTVLFQ--IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQ 4761
Query: 857 --------------------NKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE 896
++VE G + +D R K ++ L + L+
Sbjct: 4762 DVVLIKNLLISVQSRWEKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4820
Query: 897 ANVQ-------FQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLN 949
+ ++ + LA E + + K + D TN G LK+ + D
Sbjct: 4821 SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN------RTGRSLKEKTSLADDNL 4874
Query: 950 SFGDSMKALRNQANAC------QQQQAAPVEGVAGE--QRVMALYDFQARSPREVTMKK- 1000
D + LR++ + +Q + +G+ + AL D+ R ++ +
Sbjct: 4875 KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP 4934
Query: 1001 --GDVLTLLSSI-NKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQ 1057
GD+ +++ I N ++ E V A ++R A + L + R++ + +
Sbjct: 4935 VHGDIDLVMNLIDNHKAFQKELGKRTSSVQA--LKRSARE----LIEGSRDDSSWVKVQM 4988
Query: 1058 EQIENQYRSLLDRAEERRRRL---LQRYNEFLLAYEAGDMLEWIQEKKAENT----GVEL 1110
+++ ++ ++ + ++ RL L++ EF A +LEW+ E AE T GV
Sbjct: 4989 QELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA--LLEWLAE--AEQTLRFHGVLP 5044
Query: 1111 DDVWELQKKFDEFQKDLNTNEPRLRDINK 1139
DD L+ D+ ++ + E + ++NK
Sbjct: 5045 DDEDALRTLIDQHKEFMKKLEEKRAELNK 5073
Score = 125 bits (314), Expect = 5e-28
Identities = 431/2270 (18%), Positives = 886/2270 (39%), Gaps = 316/2270 (13%)
Query: 273 VTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTL 332
V + + W+ E + L ++G DL + E +HK + R + +KE AK ++ +
Sbjct: 786 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQM 843
Query: 333 SHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKT-- 390
+ P +++ ++ + L TSR ++ ++ S +EL W+NEK
Sbjct: 844 TAPLKLTYAEKLHR---LESQYAKLLNTSRNQERHLDTLHNFVSRATNELI-WLNEKEEE 899
Query: 391 -AAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVRE 449
A + E T++A + D H + E+D ++ +S E + L+ NH A +
Sbjct: 900 EVAYDWSERNTNIARKK---DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEA 956
Query: 450 KMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENE---DLGN 506
+ W+ +L+L + ++ + F+ D+++ ++ + ++ + D +
Sbjct: 957 YRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS 1016
Query: 507 SLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSE-------NIKAI--- 556
S+ E L+Q+ + +E + I + A +I +S+ IKAI
Sbjct: 1017 SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDY 1076
Query: 557 ---------RDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADD 607
D + ++ R K E+++ + K ++ ++ +
Sbjct: 1077 RQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--E 1134
Query: 608 EDYKDIQNL--KSRVQKQQVFEKELAVNKTQLENIQKTG----QEMIEGGHYASDNVTTR 661
+ Y+++ L +S + + V +N +++ I+ + + M+ G H
Sbjct: 1135 QQYQNVLTLWHESHINMKSVVSWHYLIN--EIDRIRASNVASIKTMLPGEHQQV------ 1186
Query: 662 LSEVASLWEELLEATKQKGTQLHEANQQLQFENNA--EDLQRWLEDVEWQVTSED-YGKG 718
LS + S +E+ LE +++ QL+ E N + Q L+ E + E Y
Sbjct: 1187 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 1246
Query: 719 LAEVQN-RLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEA 777
++EV+N RLR LE+ +D+ ++ + E +S QE L E
Sbjct: 1247 ISEVRNIRLR----LENC----EDR--LIRQIRTPLERDDLHESVFRITEQEKLKKELER 1296
Query: 778 LKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY-LGKDLIASKKLLNRHR 836
LK+ L T K + + + + Y + I K +N
Sbjct: 1297 LKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVN--- 1353
Query: 837 VILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQ---N 893
++L+N + E ++ K+ EE A+ + +++L ++ R+ ++ +
Sbjct: 1354 LVLKNTQAAEALVKLYE---TKLCEEEAVIAD--KNNIENLISTLKQWRSEVDEKRQVFH 1408
Query: 894 DLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAF-------LL 946
LE +Q + ++D E + KE +D + +E A L+++ + L
Sbjct: 1409 ALEDELQKAKAISD----EMFKTYKERDLD---FDWHKEKADQLVERWQNVHVQIDNRLR 1461
Query: 947 DLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTL 1006
DL G S+K R+ + ++ V QR + + Q + + + + L
Sbjct: 1462 DLEGIGKSLKYYRDTYHPLDDW----IQQVETTQR--KIQENQPENSKTLATQLNQQKML 1515
Query: 1007 LSSINKDWWKVE-----AADHQGIVPAVYVRRLAH-------DEFPMLPQRRREEPGNIT 1054
+S I K++ A + V ++ + + + P+ +R + I
Sbjct: 1516 VSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII 1575
Query: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVW 1114
Q + +Y +L+ L+ +Y +F AGD L+ ++E E +E ++
Sbjct: 1576 QEFMDLRTRYTALV--------TLMTQYIKF-----AGDSLKRLEE---EEKSLE-EEKK 1618
Query: 1115 ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADE 1174
E +K E QK ++ L+D K + ++ E ++E S +LQ +
Sbjct: 1619 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE--ALQTI--- 1673
Query: 1175 QRQLLGSAHAVEVFHREADDTKEQI------------EKKCQALSAADPGSDLFSVQALQ 1222
QL + H ++ E ++ ++Q+ E Q + G + +
Sbjct: 1674 --QLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVA 1731
Query: 1223 RRHEGFERDLVPLGDKVTILGETAERLSESHP-----DATEDLQRQKMELNEAWEDLQGR 1277
R + ++ L + D +L +T RL D T +L++ + + E +D+QG
Sbjct: 1732 ERQQEYKEKLQGICD---LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGS 1788
Query: 1278 TKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRAD 1337
+ E + + F ++ +S + Q+L E E L + ++ + +
Sbjct: 1789 AQALAEVVKNTENF------LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE 1842
Query: 1338 MEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLEL 1397
++ T E + + +IE L + D E+A K K++++Q
Sbjct: 1843 LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQ--NG 1900
Query: 1398 QMFQ--------GNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGK 1449
FQ G D+V ++ E + ++ ++L +K + I +Q
Sbjct: 1901 THFQEGDGKSAIGEEDEVNGNLL--ETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQA 1958
Query: 1450 ITDLEHFAESLIADE-HYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYAN-----LK 1503
+ A+ L+ + Y E +LQ+ + K + E K + L+
Sbjct: 1959 VIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELE 2018
Query: 1504 QFYRDLEELEEWI--SEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINL 1561
+F D E E W+ SE + D + K + ++F+ +V + +
Sbjct: 2019 KFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITIS 2078
Query: 1562 GNSLIE----CSACDGNE-------EAMKEQLEQLKEHWDHLLERTNDKGKKLNE-ASRQ 1609
GN ++E CS DG + ++ +L+ + + L + N G L + +
Sbjct: 2079 GNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY 2138
Query: 1610 QRFNTSIRDFEFWLSEAETLLA---MKDQARDLASAGNLLKKHQLLEREMLAREDALKDL 1666
Q + + L E + + A D + L++ + L+ ++ +++ A++ L
Sbjct: 2139 QHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKL 2198
Query: 1667 NTLAEDLLSS-GTF--NVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQD-L 1722
AE LL + G+ + I K D++ R+ ++ + +EKL+ QD L
Sbjct: 2199 KKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGL 2258
Query: 1723 DDEESWIEEKLIRVSSQDYGR---DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL 1779
D+ W+ + S ++ G+ + +Q+++ K+ LE ++ + +I + + +K
Sbjct: 2259 DEMLDWMGN--VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKF 2316
Query: 1780 KD-----KAAVGQEEIQLRLAQFVEHWEKLKE-LAKARGLKLEESLEYLQFMQNAEEEEA 1833
+ A+ Q +++ A+F E K KE LAK LK + L F +E+ +
Sbjct: 2317 METTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL----FENLSEKLQT 2372
Query: 1834 WINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEE 1893
++ K D S M+ ++F H+ ++ + + ++I + L +
Sbjct: 2373 FLETKTQALTEVDVPGKDVTELSQYMQEST--SEFLEHKKHLEVLHSLLKEISSHGLPSD 2430
Query: 1894 -----SQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKE 1948
+ +S K + + + +A+ + + QL+ AFQ +++WI KE
Sbjct: 2431 KALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLD---AFQVL---VKSLKSWI--KE 2482
Query: 1949 TSLKT-----NGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKD------KLIS 1997
T+ K + DLG L +DT LQ + PEI + + LIS
Sbjct: 2483 TTKKVPIVQPSFGAEDLGKSL-----EDT--KKLQEKWSLKTPEIQKVNNSGISLCNLIS 2535
Query: 1998 AQHNQSKAI-------------------EERYA--ALLKRWEQLLEAS-------AVHRQ 2029
A +KAI EE +A L + + + S + +
Sbjct: 2536 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2595
Query: 2030 KLLE---KQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHE 2086
K+ E K LQKA++ ++SA+ W +KM + ++ + + ++ E
Sbjct: 2596 KIAELNTKLSKLQKAQE-------ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVE 2648
Query: 2087 DFLASLARAQADFKCLLELDQQIKAL-----GVPSSPYTWLTVEVLERTWKHLSDIIEER 2141
+ A + + + EL ++ L P +P + ++ W+ L+ + +R
Sbjct: 2649 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2708
Query: 2142 EQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYF-LDGSLLKETGTLESQLEANK 2200
+Q+L+ E + + F+ + + QW++E + G L + L +Q + +
Sbjct: 2709 QQKLE-ESSNNLTQFQTVE------AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2761
Query: 2201 RKQKEIQAMKRQLTKIVDLGDNL-----EDALILDI-KYSTIGLAQQWDQLY-QLGLRMQ 2253
+E K Q ++ G + ED + I K + Q+WD L QL R
Sbjct: 2762 ILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCD 2821
Query: 2254 HNLEQQIQAKDIKGVS-EETLKEFSTIYKHFDENLTGRL---THKEFRSCLRGLNYYLPM 2309
++Q I +K + L+ S D L+ L TH + + + L M
Sbjct: 2822 W-IDQAI----VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN--QQLETAQKM 2874
Query: 2310 VEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENI-KSSDEIE 2358
+E + E K K A+ V E+Y + ++ E I KS ++E
Sbjct: 2875 KQEIQQEKKQIKVAQALCEDLSALVK-EEYLKAELSRQLEGILKSFKDVE 2923
Score = 124 bits (312), Expect = 9e-28
Identities = 433/2368 (18%), Positives = 888/2368 (37%), Gaps = 379/2368 (16%)
Query: 6 KETVVESSGPKVLETAEEIQERRQEV---LTRYQSFK----ERVAERGQKLEDSYHLQVF 58
K ++SS +++ +++ R + +T+Y F +R+ E + LE+ V
Sbjct: 1563 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVE 1622
Query: 59 KRDADDLGKWIMEKVNILTD--KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKT-- 114
K A +L KW+ L D K+ + P + K + E+ TK +SE +T
Sbjct: 1623 K--AKELQKWVSNISKTLKDAEKAGKPP------FSKQKISSEEISTKKEQLSEALQTIQ 1674
Query: 115 ---REERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADIL 171
+ M E + ++ L+ ++LL +LK Q Q D+
Sbjct: 1675 LFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS----------ESLKQLQESQTSGDVK 1724
Query: 172 EWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPD 231
+++ +A ER + +K + L E R++ + + +
Sbjct: 1725 V---EEKIVA---------ERQQEYKEKLQGICDLLTQTENRLIGHQEAF--MIGDGTVE 1770
Query: 232 LPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSED 291
L QSKQ E+ + ++G A + + N N ++KE L+ ED
Sbjct: 1771 LKKYQSKQEELQ---KDMQGSAQALAEVVKNTEN-------------FLKENGEKLSQED 1814
Query: 292 YGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSS 351
A++ K+ E K E+L L ++ ++
Sbjct: 1815 K---------------------ALIEQKLNEAKIKCEQLNLKAEQSKKELDKV------- 1846
Query: 352 WEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411
+ EK+ A + + L W++ N D+ ++ AG
Sbjct: 1847 ---VTTAIKEETEKVAAVKQLEESKTKIENLLDWLS------NVDK-DSERAG------- 1889
Query: 412 HQQHKHEIDSYDDRFQSADETG----QDLVNANHEASDEVREKMEILDNNWTALLELWDE 467
+HK I+ FQ D +D VN N +D + +N L + + +
Sbjct: 1890 -TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN----LNQQYQK 1944
Query: 468 RHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTA 527
Q+E+ + H Q + + SA+ LL+K + +
Sbjct: 1945 VKAQHEKIISQH---------------QAVIIATQ-------SAQVLLEKQGQY---LSP 1979
Query: 528 QEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKL 587
+E++ + + K+ HY++ ++ EK L+E L +K
Sbjct: 1980 EEKEKLQKNMKELKV----HYETALAES-------------EKKMKLTHSLQEEL--EKF 2020
Query: 588 YEDSDDLKNWINKKKKLADDEDY--KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQ 645
D + ++W+ + ++ ++ + DI L +++++Q+ F +++ +K L I +G
Sbjct: 2021 DADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGN 2080
Query: 646 EMIEGGHYASDN-------------VTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ- 691
++E S V +L + L G L + + Q
Sbjct: 2081 RVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQH 2140
Query: 692 FENNAEDLQRWLEDVEWQVT---SEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTD 748
+E+ + L L+ E + SE +Q +L + L+ ++++Q V+ L
Sbjct: 2141 YEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKK 2200
Query: 749 LAAYFEEIGH---PDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDE 805
A + P DI+ + +V R+E L + + R +KL L L +D DE
Sbjct: 2201 TAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2260
Query: 806 EA-WIQETEPSATST-YLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEG 863
W+ E S + + A + +++++ ++ ++IA + I + E+ K +E
Sbjct: 2261 MLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETT 2320
Query: 864 HFAAEDVASRVKSLNQNMESLRARAAR----------RQNDLEANVQFQQYLADLHEAET 913
S SL M+ L AR + + +L+ V+ + L++ + +T
Sbjct: 2321 D------PSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE--KLQT 2372
Query: 914 WIREKEPIVDNTNY-GADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQ--ANACQQQQA 970
++ K + + G D +++ + L+ + + +L + ++ +A
Sbjct: 2373 FLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA 2432
Query: 971 APVEGVAGEQRVMALYDFQARSPREVT---MKKGDVLTLLSSINKDWWKVEAADHQGIVP 1027
+E + + + +E ++ D +L K W K VP
Sbjct: 2433 LVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKK----VP 2488
Query: 1028 AVYVRRLAHDEFPMLPQRRR--EEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEF 1085
V A D L ++ E+ T +++ N SL + + +
Sbjct: 2489 IVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA-----VTTPAKA 2543
Query: 1086 LLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLL 1145
+ A ++G + E T ++ W K L + + + DI+ +DL
Sbjct: 2544 IAAVKSGGAV-----LNGEGTATNTEEFWA--------NKGLTSIKKDMTDISHGYEDL- 2589
Query: 1146 FEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQA 1205
GLL + ELN++ LQ+ +E ++ +++ K
Sbjct: 2590 --GLLLKDKIA---ELNTKLSKLQKAQEESSAMM--------------QWLQKMNKTATK 2630
Query: 1206 LSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKM 1265
+D +V+ +++ FE +L +KV L + L E +PD E + ++M
Sbjct: 2631 WQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQM 2690
Query: 1266 --ELNEAWEDLQGRTKDRKESLNE-AQKFYLFLSKARDLQNW-------ISSIGGM-VSS 1314
E++ W++L T DR++ L E + F + L+ W +S +G + +
Sbjct: 2691 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP 2750
Query: 1315 QELAEDLTGIEILLERHQEHRADMEAEAPTFQAL-----EDFSAELIDSGHHASPEIEKK 1369
L ++ILL+ + E Q + ED S I ++++
Sbjct: 2751 NMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGI---------VKEQ 2801
Query: 1370 LQAVKLERDDLEKAWEKRKKILDQCL-ELQMFQGNCDQVESWMVARENSLRSDDKSSL-- 1426
L AV + D L R +DQ + + +Q + + +N L S S
Sbjct: 2802 LAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP 2861
Query: 1427 DSLEALMKKRDDLDKAITAQEGKITDLEHFAESL--IADEHYAKEEIATRLQRVLDRWKA 1484
D++ ++ + + I ++ +I + E L + E Y K E++ +L+ +L +K
Sbjct: 2862 DAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKD 2921
Query: 1485 LKAQLIDERTKL-GDYANLKQFYRDLEELEEWISEMLPTACDESYKD-----ATNIQRKY 1538
++ + + L A+ QF + + + W L T +E K ++
Sbjct: 2922 VEQKAENHVQHLQSACASSHQFQQMSRDFQAW----LDTKKEEQNKSHPISAKLDVLESL 2977
Query: 1539 LK-HQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE-AMKEQLEQLKEHWDHLLERT 1596
+K H+ F+ + +S I G +L+ G+E+ A++ QL +K +WD ++
Sbjct: 2978 IKDHKDFSKTLTAQSHMYEKTIAEGENLL--LKTQGSEKAALQLQLNTIKTNWDTFNKQV 3035
Query: 1597 NDKGKKLNEA-SRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLERE 1655
++ KL E+ + ++ + W+ + + L D A N + K + L++E
Sbjct: 3036 KERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKE 3095
Query: 1656 MLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYAL 1715
M ++ LN A LLS + + + + ++ ++ V E + L+
Sbjct: 3096 MDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK 3155
Query: 1716 FQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775
F+ FQ++ E + +L Q D G Q K+ + A+++ +D+
Sbjct: 3156 FKEFQEVSKES---KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDL 3212
Query: 1776 AEKLKDKAAV------GQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829
A++L V G ++ L++ + L + + LE L+ + QN
Sbjct: 3213 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3272
Query: 1830 EE-----EAWINEKNALAVRGDCGDTL----AATQSLLMKHEAL--ENDFAVHETRVQNV 1878
E + +E +++A G +TL ++ L K EAL ND A ++
Sbjct: 3273 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM-- 3330
Query: 1879 CAQGEDILNKVLQEESQNKEISSK--IEALNEKTPSLAKAIAAWKLQLEDDY-AFQEFNW 1935
+ EE+ + K +EAL+++ L A + Q+E +EF
Sbjct: 3331 ----------LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYS 3380
Query: 1936 KADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDK- 1994
K + E ++ G + + +T++ L F+ + EI L+ K
Sbjct: 3381 KLKEFSILLQKAEEHEESQG---------PVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3431
Query: 1995 ---------LI--SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAED 2043
LI +A+ ++ +E + RW+ L +K+ ++ LQ+A
Sbjct: 3432 QDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL-------NKKVAQRAAQLQEALL 3484
Query: 2044 LFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLA-RAQADFKCL 2102
F +L +W EE ++ + ++ + Q + L L ++ + +
Sbjct: 3485 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3544
Query: 2103 LELDQQIKALGVPSSPYTWL-TVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQE 2161
++I P+ L + +L+ W+ L + E R ++L+ + Q+
Sbjct: 3545 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISV-------VAQQ 3597
Query: 2162 FEQNASTFLQWILETRAYFLDGSLL-KETGTLESQLEANKRKQKEIQAMKRQLTKIVDLG 2220
F + +W+ ++ + + LE Q+ +K + +I + L + V +G
Sbjct: 3598 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3657
Query: 2221 DNL------EDALILDIKYSTIGLAQQW 2242
+L ED D+ S + +Q W
Sbjct: 3658 QSLKVLSSREDK---DMVQSKLDFSQVW 3682
Score = 122 bits (306), Expect = 4e-27
Identities = 304/1638 (18%), Positives = 627/1638 (38%), Gaps = 208/1638 (12%)
Query: 16 KVLETAEE---IQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIME 71
KVL + E+ +Q + Y +E+ R + L+ + + ++F D +L W+ E
Sbjct: 3661 KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNE 3720
Query: 72 KVNILTDKSYEDPTNIQGKYQKHQSLEA--------EVQTKSRLMSELE---KTREERFT 120
+ L+ S +D + +G +++ L + L++ LE +T +
Sbjct: 3721 VHDKLSKLSVQDYST-EGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL 3779
Query: 121 MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAI 180
+ E KA +++ L + + TLE+ QL R L ++ W+ E
Sbjct: 3780 IIQDKLEAIKARYKDITKLSTDVAK-TLEQALQLARRLHSTH-----EELCTWLDKVEVE 3833
Query: 181 ATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYA-----NECAEENHPDLPL- 234
S E T+VL K E Q ++ KE + N A NE + +P
Sbjct: 3834 LLSYE-------TQVL-KGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWR 3885
Query: 235 ----IQSKQNEVNAAWERLRGLALQRQKALSNAA-NLQRFKRDVTEAIQWIKEKEPVLTS 289
++ E N + + Q+ + + A Q+F + + WI E E L S
Sbjct: 3886 AREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMS 3945
Query: 290 -EDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDL 348
D + + K + D + +L K+ + + Q + K D
Sbjct: 3946 LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK 4005
Query: 349 V-SSWEHIRALATSRYEKLQ-ATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGE 406
V +++ I + + RY +L+ A ++F ++EL W+ E + I+ +LP E
Sbjct: 4006 VLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS--QLPAPALEYE 4063
Query: 407 VLLDRHQQHKHE---IDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLE 463
L + ++H+ I + ++TG L+ + ++EK D ++ + E
Sbjct: 4064 TLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 4123
Query: 464 LWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEE 523
+R ++ + + D ++D + E +E S+ + +++ +
Sbjct: 4124 DVKKRAVALDEAISQSTQFHD--KIDQILESLERIVERLRQPPSISAEVEKIKEQISENK 4181
Query: 524 AFTAQEEKII----TVDKTATKLIGDDHYDSENI--KAIRDGLLAR-------RDALREK 570
+ EK+ T+ + ++I ++I KA++D L + E+
Sbjct: 4182 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 4241
Query: 571 AATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQN--LKSRVQKQQVFEK 628
A +LL L +K + D L I + D + I +K + + + +
Sbjct: 4242 EA---KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 4298
Query: 629 ELAVNKTQLENIQKTGQEMIEG-GHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEAN 687
E+ + +L+ + G E+I G V + E+ S W+ L +A K + +L EA
Sbjct: 4299 EIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAM 4358
Query: 688 QQ-LQFENNAEDLQRWLEDVEWQVTS-EDYGKGLAEVQNRLRKHGLLESAVAARQDQVDI 745
Q +Q+++ + + W++ ++ S G L V+ ++ + +S +Q +++
Sbjct: 4359 QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER 4418
Query: 746 LTDLAAYF--EEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLD-LLHLQLICRDT 802
L A + D ++ L +++L+E + R+ KL LL L
Sbjct: 4419 LNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHAL 4478
Query: 803 EDEEAWIQETEPSATSTY-LGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVE 861
++ AW+ TE + +G D A + L +H V+ ++ +H+ ++ + + GN ++E
Sbjct: 4479 DELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIE 4538
Query: 862 -EGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANV-QFQQYLADLHEAETWIREKE 919
A ++ ++++ LNQ +++ + +R+ L+ + Q + + ++ + + W+ + E
Sbjct: 4539 SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTE 4598
Query: 920 -PIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAG 978
++ + G E A L H + ++ K+L + G
Sbjct: 4599 RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQK----------------G 4642
Query: 979 EQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDE 1038
+Q + AR P+ + ++ ++++ + W VE ++ LA +
Sbjct: 4643 QQML-------ARCPKSA---ETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEF 4692
Query: 1039 FPMLPQ-----RRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGD 1093
L + E+ N+ R I + +D + + + + + G
Sbjct: 4693 HNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGT 4752
Query: 1094 MLEWIQEKK----AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGL 1149
L++ +K+ +N + + WE KV L+ G
Sbjct: 4753 HLKYFSQKQDVVLIKNLLISVQSRWE-----------------------KVVQRLVERGR 4789
Query: 1150 LTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAA 1209
+ + ++ + W L +E + L S + A
Sbjct: 4790 SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEI----------------------AN 4827
Query: 1210 DPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKM--EL 1267
DP D Q Q H+ F++ L T L E A ++L+ M EL
Sbjct: 4828 DP--DKIKTQLAQ--HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4883
Query: 1268 NEAWEDLQGRTKDRKESLNEAQKFY-LFLSKARDLQNWISSI-GGMVSSQELAEDLTGIE 1325
+ W+ + G++ +R+ L EA F F + L +W+ + + Q + D+ +
Sbjct: 4884 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4943
Query: 1326 ILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWE 1385
L++ H+ + ++ + QAL+ + ELI+ S VK++ +L WE
Sbjct: 4944 NLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-------SWVKVQMQELSTRWE 4996
Query: 1386 --------KRKKILDQCLELQMFQGNCDQVESWMVARENSLR-----SDDKSSLDSL--- 1429
K+ ++ + + F + W+ E +LR DD+ +L +L
Sbjct: 4997 TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ 5056
Query: 1430 -----EALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKA 1484
+ L +KR +L+KA T + + +S+ +H+ I R + VL K
Sbjct: 5057 HKEFMKKLEEKRAELNKATTMGDTVLAICH--PDSITTIKHWI-TIIRARFEEVLAWAKQ 5113
Query: 1485 LKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESY----KDATNIQRKYLK 1540
+ +L A L LE L W+ T D+ ++ ++ +
Sbjct: 5114 HQQRLASA------LAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE 5167
Query: 1541 HQTFAHEVDGRSEQVHGV 1558
HQTF E+ + V V
Sbjct: 5168 HQTFMEEMTRKQPDVDKV 5185
Score = 105 bits (262), Expect = 5e-22
Identities = 429/2370 (18%), Positives = 878/2370 (37%), Gaps = 423/2370 (17%)
Query: 187 GEDWERTEVLHKKFEDF----QVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNE- 241
GE + L +FEDF Q V + ++ + N C + L + ++ E
Sbjct: 1181 GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEE 1240
Query: 242 --VNAAWERLRGLALQRQKALSNAANLQRF---KRDVTEAIQWIKEKEPVLTSEDYGKDL 296
N +R + L+ + R + D+ E++ I E+E + + KD
Sbjct: 1241 SVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD- 1299
Query: 297 VASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIR 356
+L +++K +E ++A + S P ++ ++ + +
Sbjct: 1300 ---------------DLGTITNKCEEFFSQA-----AASSSVPTLRSELNVVLQNMNQVY 1339
Query: 357 ALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHK 416
+++++ +KL+ + + + L K A + D E L+ +Q +
Sbjct: 1340 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA--VIADKNNIENLISTLKQWR 1397
Query: 417 HEID-------SYDDRFQSADETGQDLVNANHEAS---DEVREKMEILDNNWTALLELWD 466
E+D + +D Q A ++ E D +EK + L W + D
Sbjct: 1398 SEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1457
Query: 467 ERHRQYEQCLDFHLFYRDS-EQVDSWMSRQEAF---LENEDLGNSLGSAEALLQKHEDFE 522
R R E +YRD+ +D W+ + E ++ NS A L Q
Sbjct: 1458 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQ------ 1511
Query: 523 EAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLL------ARRDALREKAATRRR 576
Q+ + ++ +K+ Y + ++D L A D+ ++ RRR
Sbjct: 1512 -----QKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRR 1566
Query: 577 LLKESLLLQKLYED-------------------SDDLKNWINKKKKLADD-----EDYKD 612
+ + L+ + + D D LK ++K L ++ E K+
Sbjct: 1567 MQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKE 1626
Query: 613 IQNLKSRVQK---------------QQVFEKELAVNKTQLEN--------IQKTGQEMIE 649
+Q S + K Q++ +E++ K QL + K G +M +
Sbjct: 1627 LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTD 1686
Query: 650 GGHYASDNVTTRLSEVASLW-----EELLEATKQKGTQLHE---ANQQLQFENNAEDLQR 701
+ L E +L ++L E+ ++ E A +Q +++ + +
Sbjct: 1687 EERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICD 1746
Query: 702 WLEDVEWQVTSED----YGKGLAEVQNRLRKHGLLESAV-AARQDQVDILTDLAAYFEEI 756
L E ++ G G E++ K L+ + + Q +++ + + +E
Sbjct: 1747 LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1806
Query: 757 GHPDSKDIRARQESLVCRFEALKEPL---ATRKKKLLDLLHLQLICRDTEDEEAWIQETE 813
G S++ +A E + + E L A + KK LD + I +TE A +++ E
Sbjct: 1807 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA-VKQLE 1865
Query: 814 PSATSTYLGKDLIA-----SKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAE 868
S T D ++ S++ +H+ ++E +H + G + G+
Sbjct: 1866 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1925
Query: 869 DVASRV----KSLNQNMESLRARAARRQNDLEANV---QFQQYLADLHEAETWIREKEPI 921
DV +V ++LNQ + ++A+ + + +A + Q Q L + EKE +
Sbjct: 1926 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1985
Query: 922 VDN-----TNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGV 976
N +Y + +K + +L F + +Q+ G
Sbjct: 1986 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 2045
Query: 977 AGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQ--GIVPAVYVRRL 1034
+M Q +V KGD+ + S N+ ++ + G V R
Sbjct: 2046 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHRE 2105
Query: 1035 AHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDM 1094
+ R R ++ + + N + L+D+ Q Y + AG
Sbjct: 2106 VQRKLDHATDRFR----SLYSKCNVLGNNLKDLVDK--------YQHYEDASCGLLAGLQ 2153
Query: 1095 LEWIQEKKAENTGVELDDVWELQKKFDE---FQKDLNTNEPRLRDINKVADDLL-FEGLL 1150
K + + +D LQ++ +E Q +++ + + + K A+ LL G L
Sbjct: 2154 ACEATASKHLSEPIAVDPK-NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSL 2212
Query: 1151 TPEGAQIRQELNS---RWGSLQRLADEQRQ----LLGSAHAVEVFHREADDTKEQIEKKC 1203
P I++ L+ R+ L + +E+ + L + +V+ E D +E
Sbjct: 2213 LPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL 2272
Query: 1204 QALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSES-HPDATEDLQR 1262
+ S ++Q + ++ E+D+ + + E ++ E+ P LQ
Sbjct: 2273 KEQGQVPLNST--ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQA 2330
Query: 1263 QKMELNEAWEDLQGRTKDRKESLNEAQ-KFYLFLSKARDLQNWISSIGGMVSSQELAE-D 1320
+ +L+ + + + K+ + E + K LF + + LQ ++ + +Q L E D
Sbjct: 2331 KMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLET-----KTQALTEVD 2385
Query: 1321 LTGIEI--LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIE-KKLQAVKLER 1377
+ G ++ L + QE ++ + L E+ G + + +K + +
Sbjct: 2386 VPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKF 2445
Query: 1378 DDLEKAWEKRKKILDQCLE-LQMFQGNCDQVESWMV--------------------AREN 1416
++E +++K+ + C E L FQ ++SW+ + E+
Sbjct: 2446 KEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLED 2505
Query: 1417 SLRSDDKSSLDSLEALMKKRDDLD------------KAITAQEGKITDLEHFAESLIADE 1464
+ + +K SL + E + KAI A + L + +E
Sbjct: 2506 TKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEE 2565
Query: 1465 HYA-------KEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWIS 1517
+A K+++ D LK ++ + TKL + L++ + + +W+
Sbjct: 2566 FWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL---SKLQKAQEESSAMMQWLQ 2622
Query: 1518 EMLPTACD----ESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDG 1573
+M TA + D ++ + ++++F E+ +V + + L+E +
Sbjct: 2623 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2682
Query: 1574 NEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQ-QRFNTSIRDFEFWLSEAETLLAM 1632
K+ L ++ W L + T D+ +KL E+S +F T + WL E E ++++
Sbjct: 2683 EAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV 2742
Query: 1633 KDQARDLASAGNLL----KKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688
L+ N+L ++ Q+L +E R+ + L + +LS +
Sbjct: 2743 ---LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS----------RPG 2789
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748
++ + R + ++LAA + L D WI++ +++ S Y L+ +
Sbjct: 2790 EDPSLRGIVKEQLAAVTQK-------WDSLTGQLSDRCDWIDQAIVK--STQYQSLLRSL 2840
Query: 1749 QNLLKK-HKRLEGELV--AHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLK 1805
+ L +L L H A+ L+ A+K+K + + QE+ Q+++AQ + E L
Sbjct: 2841 SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE--IQQEKKQIKVAQAL--CEDLS 2896
Query: 1806 ELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALE 1865
L K LK E S + + +L + +E
Sbjct: 2897 ALVKEEYLKAELSRQ---------------------------------LEGILKSFKDVE 2923
Query: 1866 NDFAVHETRVQNVCAQGEDILNKVLQEESQNKE--ISSKIEALNEKTPSLAKAIAAWKLQ 1923
H +Q+ CA Q+ S++ + + +K E N+ P A
Sbjct: 2924 QKAENHVQHLQSACASSHQ-----FQQMSRDFQAWLDTKKEEQNKSHPISA--------- 2969
Query: 1924 LEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQE 1983
K DV+E+ I D + KT + QS E
Sbjct: 2970 ------------KLDVLESLIKDHKDFSKT---------------------LTAQSHMYE 2996
Query: 1984 RLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAED 2043
+ I + ++ L+ Q ++ A++ + + W+ +++ E++ L+++ +
Sbjct: 2997 K--TIAEGENLLLKTQGSEKAALQLQLNTIKTNWD-------TFNKQVKERENKLKESLE 3047
Query: 2044 LFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLL 2103
+++ + L W +K + NL E C+ + E+ +A L Q
Sbjct: 3048 KALKYKEQVETLWPWIDKCQNNLEEIKFCLD-------PAEGENSIAKLKSLQK------ 3094
Query: 2104 ELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFE 2163
E+DQ VE+L T L + E ++ + E ++ +M E
Sbjct: 3095 EMDQHFG------------MVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE-- 3140
Query: 2164 QNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL 2223
L ++ + L+ T + E +K ++++Q K QL D+ D+L
Sbjct: 3141 ---------QLHSKKFCLENM----TQKFKEFQEVSKESKRQLQCAKEQL----DIHDSL 3183
Query: 2224 EDALILDIKYSTIGLAQQWD---QLYQLGLRMQHNLEQQIQAKDIKGVSEETL------K 2274
+ KY T+ QQ +Q+ L + + ++A D KG S+ L +
Sbjct: 3184 GSQAYSN-KYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQ 3242
Query: 2275 EFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHE-PKFEKFLDAVDPGRKGY 2333
E ST+ + DE + T L+G+ ++ + E + +F+ LD++ P +
Sbjct: 3243 EHSTLSQQVDEKCSFLETK------LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3296
Query: 2334 VSL----EDYTAFLIDKESENIKSSDEIEN 2359
+L E AFL K+ E + +S++ N
Sbjct: 3297 ETLQKQKETIKAFL--KKLEALMASNDNAN 3324
Score = 90.1 bits (222), Expect = 2e-17
Identities = 319/1812 (17%), Positives = 680/1812 (37%), Gaps = 242/1812 (13%)
Query: 697 EDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAV--------AARQDQVDILTD 748
+DL W+++++ Q+ ++G L V++ L H + A+ A+ ++ +
Sbjct: 787 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP 846
Query: 749 LAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAW 808
L + E H R ES + + +++ LD LH + R T +E W
Sbjct: 847 LKLTYAEKLH--------RLESQYAKL----LNTSRNQERHLDTLH-NFVSRAT-NELIW 892
Query: 809 IQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAE 868
+ E E + + + + H ++ + E I+ + E +++ E H A
Sbjct: 893 LNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 952
Query: 869 DVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYG 928
+ + ++ + + ++ N + ++ D EA ++R + + Y
Sbjct: 953 TIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR-KYS 1011
Query: 929 ADEEAAGALLK--------------KHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVE 974
D ++ L+ ++++ + +L ++ L+ + + C + + P++
Sbjct: 1012 CDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIK 1071
Query: 975 GVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKV-EAADHQGIVPAVYVRR 1033
+ +++ E+T+ K D L ++ ++ WKV ++ +VP+V
Sbjct: 1072 AICDYRQI------------EITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVC--- 1116
Query: 1034 LAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGD 1093
F + P + E ++ R IE QY+++L E + + L E
Sbjct: 1117 -----FTVPPPNK--EAVDLANR---IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDR 1166
Query: 1094 M-LEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTP 1152
+ + K G + LQ +F++F +D ++ +F G
Sbjct: 1167 IRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQ-------------VFSG---S 1210
Query: 1153 EGAQIRQELNSRWGSLQRL-----ADEQRQLLGSAHAVEV--FHREADDTKEQIEKKCQA 1205
+ Q+ +E+N Q L +EQ + + + + EV ++ ++++ ++ +
Sbjct: 1211 DITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 1270
Query: 1206 -LSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQK 1264
L D +F + ++ + ER LG TI + E S++ A+ + +
Sbjct: 1271 PLERDDLHESVFRITEQEKLKKELERLKDDLG---TITNKCEEFFSQA--AASSSVPTLR 1325
Query: 1265 MELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQE-LAEDLTG 1323
ELN +++ +++ + L L + + + + +E + D
Sbjct: 1326 SELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNN 1385
Query: 1324 IEILLERHQEHRADMEAEAPTFQALED---FSAELIDSGHHASPEIEKKLQAVKLERDDL 1380
IE L+ ++ R++++ + F ALED + + D E + K + D L
Sbjct: 1386 IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 1445
Query: 1381 EKAWEKRKKILDQCL--------ELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEAL 1432
+ W+ +D L L+ ++ ++ W+ E + R ++ ++ + L
Sbjct: 1446 VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTL 1505
Query: 1433 ---MKKRDDLDKAITAQEGKITDLEHFAESLIAD-EHYAKEEIATRLQRVLDRWKALKAQ 1488
+ ++ L I ++ K+ + + +AE A + Y + + R + +K +
Sbjct: 1506 ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR 1565
Query: 1489 LIDERTKL--GDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAH 1546
+ L ++ +L+ Y L L + + ++ +++ + +H A
Sbjct: 1566 RMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAK 1625
Query: 1547 E----VDGRSEQVHGVINLGNSLIECSACDGNE-EAMKEQLEQLKEHWDHLLERTNDKGK 1601
E V S+ + G E KEQL + + L + DK
Sbjct: 1626 ELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMT 1685
Query: 1602 KLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLARED 1661
+++ T + SE+ L + D+ ++ + Q +E L
Sbjct: 1686 DEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKL---Q 1742
Query: 1662 ALKDLNTLAED---------LLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEA 1712
+ DL T E+ ++ GT + + K++ + K ++Q A A E +K
Sbjct: 1743 GICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQK---DMQGSAQALAEVVK-- 1797
Query: 1713 YALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNV 1772
+ E++++E ++S +D Q + K ++L + + + V
Sbjct: 1798 -----------NTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKV 1846
Query: 1773 LDMA--EKLKDKAAVGQ-EEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829
+ A E+ + AAV Q EE + ++ ++ + + ++ G K ++ +E
Sbjct: 1847 VTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEG 1906
Query: 1830 EEEAWINEKNAL-------AVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQG 1882
+ ++ I E++ + V G G T K +A +++ + + + + Q
Sbjct: 1907 DGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA-QHEKIISQHQAVIIATQS 1965
Query: 1883 EDIL----NKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKAD 1938
+L + L E + K + E +LA++ KL ++F+
Sbjct: 1966 AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYT 2025
Query: 1939 VVEAWIADKETSLKTNGNGA-DLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLIS 1997
E W+ E L+ GA D+ +T L +Q +SF ++ + DL+ IS
Sbjct: 2026 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQ-------KSFSEDVISHKGDLRYITIS 2078
Query: 1998 AQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNN 2057
+ E + KR ++ SA HR E Q L A D F K + L N
Sbjct: 2079 GNR-----VLEAAKSCSKRDGGKVDTSATHR----EVQRKLDHATDRFRSLYSKCNVLGN 2129
Query: 2058 ------------------------WCE-KMEENLSEPVHCVSLNEIRQLQ--KDHEDFLA 2090
CE ++LSEP+ N RQL+ K + ++
Sbjct: 2130 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQIS 2189
Query: 2091 SLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEA 2150
S A K E+ + +P+ T++ + ++ LS + ER ++LQ
Sbjct: 2190 SQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLT 2249
Query: 2151 RQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEAN-KRKQKEIQAM 2209
R + + E + E L+ + L++ + LE + +Q I AM
Sbjct: 2250 RSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAM 2309
Query: 2210 KRQLTKIVDLGDNLEDALI------LDIKYSTIG------------LAQQWDQLYQLGLR 2251
++ K ++ D + + L ++S L + + L +
Sbjct: 2310 NEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEK 2369
Query: 2252 MQHNLEQQIQA---KDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLP 2308
+Q LE + QA D+ G K+ + + ++ E+ + L HK+ L L
Sbjct: 2370 LQTFLETKTQALTEVDVPG------KDVTELSQYMQESTSEFLEHKKHLEVLHSL----- 2418
Query: 2309 MVEEDEHEPKFEK--FLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALAE 2366
+ E H +K L+ + K + +ED I ++ E + S E +AFQ L +
Sbjct: 2419 LKEISSHGLPSDKALVLEKTNNLSKKFKEMED----TIKEKKEAVTSCQEQLDAFQVLVK 2474
Query: 2367 GKSYITKEDMKQ 2378
KE K+
Sbjct: 2475 SLKSWIKETTKK 2486
Score = 69.7 bits (169), Expect = 3e-11
Identities = 423/2395 (17%), Positives = 896/2395 (37%), Gaps = 430/2395 (17%)
Query: 68 WIMEKVN--ILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSA 125
W+ EK + D S E TNI K H L E+ K + +++ E+ H A
Sbjct: 892 WLNEKEEEEVAYDWS-ERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPA 950
Query: 126 HEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGD-KEA----- 179
+A+ ++ W +L+L +Q+++E E+ D KEA
Sbjct: 951 RLTIEAYRAAMQTQWSWILQL----------CQCVEQHIKENTAYFEFFNDAKEATDYLR 1000
Query: 180 -IATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSK 238
+ +++ +R+ +HK + Q + KE E+ QY + A +IQ K
Sbjct: 1001 NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKE----ELLQYKSTIANLMGKAKTIIQLK 1056
Query: 239 QNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVA 298
+ + + KA+ + ++ I K+ E VL +
Sbjct: 1057 PRNSDCPLKTSIPI-----KAICDYRQIE---------ITIYKDDECVLAN--------- 1093
Query: 299 SEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRAL 358
+SH+ + ++ ++ A + + P + ++ + ++++ L
Sbjct: 1094 -----NSHRAKWKVISPTGNE-----AMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL 1143
Query: 359 ATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHE 418
+ +++ +H ++ D + A N + T + G +H+
Sbjct: 1144 WHESHINMKSVVSWHYLINEIDRI--------RASNVASIKTMLPG---------EHQQV 1186
Query: 419 IDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDF 478
+ + RF+ E Q+ + ++ +++ + + LL+ ER Q E +
Sbjct: 1187 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKS-AEREEQEESVYNL 1245
Query: 479 HLF------YRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKI 532
++ R D + + LE +DL S+ + + E ++ ++ +
Sbjct: 1246 YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESV----FRITEQEKLKKELERLKDDL 1301
Query: 533 ITVDKTATKLIGDDHYDSE--NIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYED 590
T+ + S +++ + +L + + ++T LK L+ K +
Sbjct: 1302 GTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA 1361
Query: 591 SDDLKNWINKKKKLADDE----DYKDIQNLKSRV--------QKQQVF---EKELAVNKT 635
++ L + KL ++E D +I+NL S + +K+QVF E EL K
Sbjct: 1362 AEALVKLY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKA 1419
Query: 636 QLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FEN 694
+ + KT +E D + ++ W+ + + L + L+ + +
Sbjct: 1420 ISDEMFKTYKER----DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRD 1475
Query: 695 NAEDLQRWLEDVE--WQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAY 752
L W++ VE + E+ + + +L + +L S + +Q ++D A
Sbjct: 1476 TYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ 1535
Query: 753 FEEI----------------GHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQ 796
+ S R R +S L TR L+ L+
Sbjct: 1536 YSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQY 1595
Query: 797 LICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERG 856
+ + D ++E E S K+ + + + + + +++ +++ + G
Sbjct: 1596 I--KFAGDSLKRLEEEEKSLEE--------EKKEHVEKAKELQKWVSNISKTLKDAEKAG 1645
Query: 857 NKMVEEGHFAAEDVASRVKSLNQNMESLRARAAR--------RQNDLEA---------NV 899
+ ++E+++++ + L++ +++++ A+ +N+LE N+
Sbjct: 1646 KPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNL 1705
Query: 900 QFQQYLADLHEAETW--IREKEPIVDNTNYGADEEAAG----------ALLKKHEAFLLD 947
F + L L E++T ++ +E IV E+ G L+ EAF++
Sbjct: 1706 LFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI- 1764
Query: 948 LNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLL 1007
GD L+ Q +Q + + G + +A EV + L
Sbjct: 1765 ----GDGTVELKKY----QSKQEELQKDMQGSAQALA----------EVVKNTENFL--- 1803
Query: 1008 SSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSL 1067
++ K+ D I + ++ ++ + ++ ++E + + E + +
Sbjct: 1804 ---KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA 1860
Query: 1068 LDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQ--EKKAENTGVELDDVWELQKKFDEFQK 1125
+ + EE + ++ ++L+W+ +K +E G + V +++ FQ+
Sbjct: 1861 VKQLEESKTKI-------------ENLLDWLSNVDKDSERAGTKHKQV--IEQNGTHFQE 1905
Query: 1126 DLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAV 1185
+ + + ++V +LL E + + ++ LN ++ Q++ + +++ AV
Sbjct: 1906 --GDGKSAIGEEDEVNGNLL-ETDVDGQVGTTQENLNQQY---QKVKAQHEKIISQHQAV 1959
Query: 1186 EVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGET 1245
+ + A + +EK+ Q LS + +++ L+ +E L K+ +
Sbjct: 1960 IIATQSA---QVLLEKQGQYLSPEEKEKLQKNMKELKVH---YETALAESEKKMKLTHSL 2013
Query: 1246 AERLSESHPDATED---LQRQKMELNE---AWEDLQG------RTKDRKESL--NEAQKF 1291
E L + D TE LQ+ + EL +D+ G R K E + ++
Sbjct: 2014 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 2073
Query: 1292 YLFLSKARDLQ---NWISSIGGMVSSQELAEDLTGIEILLERHQEHRAD-MEAEAPTFQA 1347
Y+ +S R L+ + GG V D + ++R +H D +
Sbjct: 2074 YITISGNRVLEAAKSCSKRDGGKV-------DTSATHREVQRKLDHATDRFRSLYSKCNV 2126
Query: 1348 LEDFSAELIDSGHH---ASPEIEKKLQAVK--LERDDLEKAWEKRKKILDQCLELQMFQG 1402
L + +L+D H AS + LQA + + E K + Q E + QG
Sbjct: 2127 LGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQG 2186
Query: 1403 NCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIA 1462
Q+ S VA E L+ + LD+ +L+ ++D+ K + G+ DL S
Sbjct: 2187 ---QISSQQVAVE-KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDL-----SKSV 2237
Query: 1463 DEHYAKEEIA-TRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLP 1521
+E K +I TR V D L+E+ +W+ +
Sbjct: 2238 NERNEKLQITLTRSLSVQD---------------------------GLDEMLDWMGNVES 2270
Query: 1522 TACDESY--KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMK 1579
+ ++ ++T +Q K+ ++ GR ++ AM
Sbjct: 2271 SLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSIN--------------------AMN 2310
Query: 1580 EQLEQLKEHWD-----HLLERTNDKGKKLNEAS--------RQQRFNTSIRDFEFWLSEA 1626
E++++ E D L + D + +EAS + + T + FE +
Sbjct: 2311 EKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKL 2370
Query: 1627 ETLLAMKDQA--------RDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGT 1678
+T L K QA +D+ +++ E L + L+ L++L +++ S G
Sbjct: 2371 QTFLETKTQALTEVDVPGKDVTELSQYMQES---TSEFLEHKKHLEVLHSLLKEISSHGL 2427
Query: 1679 FNVDQIV-KKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDL-DDEESWIEEKLIRV 1736
+ +V +K +N++K+F +++ E + FQ L +SWI+E +V
Sbjct: 2428 PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV 2487
Query: 1737 SSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL-----------KDKAAV 1785
+ + L+ K+L+ + P IQ V + L K AAV
Sbjct: 2488 PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAV 2547
Query: 1786 -----------------------GQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYL 1822
G I+ + +E L L K + +L L L
Sbjct: 2548 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL 2607
Query: 1823 QFMQNAEEEEA----WINEKNALAVRGDCGDTLAATQSLLMKHEALEN-DFAVHETRVQN 1877
Q A+EE + W+ + N A + T A T + +K + +N F + N
Sbjct: 2608 ---QKAQEESSAMMQWLQKMNKTATKWQ--QTPAPTDTEAVKTQVEQNKSFEAELKQNVN 2662
Query: 1878 VCAQGEDILNKVLQEESQN----------KEISSKIEALNEKTPSLAKAIAAWKLQLEDD 1927
+ +D L ++L+E EI SK + LN+ T + + E
Sbjct: 2663 KVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE------ESS 2716
Query: 1928 YAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSF--QQERL 1985
+F ++ W+ +KE + G + + L +Q + LQ F ++ +
Sbjct: 2717 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQ--VQILLQEFATRKPQY 2774
Query: 1986 PEITDLKDKLISAQHNQSK---AIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE 2042
++T ++S ++E+ AA+ ++W+ L + + + + + +
Sbjct: 2775 EQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQ 2834
Query: 2043 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLN-EIRQLQKDHEDFLASLARAQADFKC 2101
L + K S L+N K+ +L+ H ++N ++ QK ++ + + + K
Sbjct: 2835 SLLRSLSDKLSDLDN---KLSSSLAVSTHPDAMNQQLETAQKMKQE----IQQEKKQIKV 2887
Query: 2102 LLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQE 2161
L + + AL L+ + LE K D+ ++ E +Q ++ + +
Sbjct: 2888 AQALCEDLSALVKEEYLKAELSRQ-LEGILKSFKDVEQKAENHVQHLQSACASS----HQ 2942
Query: 2162 FEQNASTFLQWILETRAYFLDGS--LLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDL 2219
F+Q + F W L+T+ + S + + LES ++ +K K + A K +
Sbjct: 2943 FQQMSRDFQAW-LDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE 3001
Query: 2220 GDNL------EDALILDIKYSTIGLAQQWD----QLYQLGLRMQHNLEQQIQAKD 2264
G+NL + L ++ +TI WD Q+ + +++ +LE+ ++ K+
Sbjct: 3002 GENLLLKTQGSEKAALQLQLNTI--KTNWDTFNKQVKERENKLKESLEKALKYKE 3054
Score = 41.2 bits (95), Expect = 0.012
Identities = 42/210 (20%), Positives = 92/210 (43%), Gaps = 23/210 (10%)
Query: 574 RRRLLKESLLLQKLYEDS------DDLKNWINKKKKLADDEDY-KDIQNLKSRVQKQQ-- 624
R+ LLK SLL Q L E+ DL NW+++ + D ++ D+ +++S ++ +
Sbjct: 763 RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNV 822
Query: 625 ---VFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGT 681
+ E E ++ + ++ IQ T + YA +L + S + +LL ++ +
Sbjct: 823 HRAIEEFESSLKEAKISEIQMTAPLKLT---YAE-----KLHRLESQYAKLLNTSRNQER 874
Query: 682 QLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQD 741
L + F + A + WL + E + + D+ + + + H L + +++
Sbjct: 875 HLDTLH---NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 931
Query: 742 QVDILTDLAAYFEEIGHPDSKDIRARQESL 771
+ + ++A HP I A + ++
Sbjct: 932 NIKSVQEIAEQLLLENHPARLTIEAYRAAM 961
Score = 40.8 bits (94), Expect = 0.016
Identities = 60/342 (17%), Positives = 134/342 (39%), Gaps = 53/342 (15%)
Query: 1707 EKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHE 1766
+ L E +F QDL +W++E +++ ++G DL V++ L+ HK + + E
Sbjct: 774 QNLTEEEINMKFVQDL---LNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFE 830
Query: 1767 PAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKL------EESLE 1820
+++ K+ EIQ+ + + EKL L L E L+
Sbjct: 831 SSLKEA-----KI--------SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLD 877
Query: 1821 YL-QFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVC 1879
L F+ A E W+NEK + E + D++ T +
Sbjct: 878 TLHNFVSRATNELIWLNEK---------------------EEEEVAYDWSERNTNIARKK 916
Query: 1880 AQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADV 1939
+++ ++ Q+E K + E L + I A++ ++ +++
Sbjct: 917 DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSW--ILQLCQC 974
Query: 1940 VEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQ 1999
VE I + + + + D+L ++ DA + + +R I L+D + +
Sbjct: 975 VEQHIKENTAYFEFFNDAKEATDYL-----RNLKDAIQRKYSCDRSSSIHKLEDLVQESM 1029
Query: 2000 HNQSKAIEER--YAALLKRWEQLLEASAVHRQKLLEKQLPLQ 2039
+ + ++ + A L+ + + +++ + L+ +P++
Sbjct: 1030 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIK 1071
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 214 bits (546), Expect = 6e-55
Identities = 443/2242 (19%), Positives = 900/2242 (40%), Gaps = 244/2242 (10%)
Query: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQV-FKRDADDLGKWIMEKVNILTD-KSY 81
+Q + + T + +F ++V ER KL++S + +K + L WI + N L + K
Sbjct: 2839 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2898
Query: 82 EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHE----ETKAHIE--- 134
DP + K +SL+ E+ ++ L T ++ E E K+ I+
Sbjct: 2899 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2958
Query: 135 ---ELRHLWDLLLELTLEKGDQLLRALKFQQYVQECA----DILEWIGDK---------- 177
E H LE +K + K + +CA DI + +G +
Sbjct: 2959 MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML 3018
Query: 178 -------EAIATSVELGEDWERTEVLH----KKFED--FQVELVAKEGRVVEVNQYANEC 224
+A+ V+L + + V+ K D QVE +A+E + +Q +E
Sbjct: 3019 QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL--SQQVDEK 3076
Query: 225 AEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKE 284
L I QN + + + + + + ++ ++K+ E
Sbjct: 3077 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLE 3136
Query: 285 PVLTSEDYG----KDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQ 340
++ S D K ++A+E G++R+L +S + +L +A+
Sbjct: 3137 ALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR---------- 3186
Query: 341 IQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPT 400
+E E + E Y KL+ + + + +E G + +T IN
Sbjct: 3187 -EEQVEGTIKRLEEF-------YSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMF 3238
Query: 401 DVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN--ANHEASDEVREKMEILDNNW 458
V K EI+ + Q + GQ L+ A ++ + ++ ++ W
Sbjct: 3239 KVF-----------QKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3287
Query: 459 TALLELWDERHRQYEQCLDFHLFYRDS-EQVDSWMSRQEAFLENEDLGNS-LGSAEALLQ 516
L + +R Q ++ L ++D+ E + SWM E + N+ ++ +A +Q
Sbjct: 3288 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3347
Query: 517 KHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLL--ARRDALREKAATR 574
+ + + ++ + + + K I ++ +K ++ L +R +AL KA TR
Sbjct: 3348 EQKLLQRLLDDRKSTVEVIKREGEK-IATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3406
Query: 575 RRLLKE-SLLLQKLYEDSDDLKNWINK-KKKLADDEDY-KDIQNLKSRVQKQQVFEKELA 631
R L+ S++ Q+ +E + L W+ +K+L + E L+ ++ + + E ++
Sbjct: 3407 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3466
Query: 632 VNKTQLENIQKTGQEM-IEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEA--NQ 688
+ L GQ + + D V ++L + E+ E + + L +A N
Sbjct: 3467 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3526
Query: 689 QLQFENNAEDLQRWLEDVEWQVTS---EDYG-KGLAEVQNRLRKHGLLESAVAARQDQVD 744
++ E+ E L WL +V +++ +DY +GL + Q+ LR +L+ + R+ VD
Sbjct: 3527 KIFGEDEVE-LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR---VLQEDILLRKQNVD 3582
Query: 745 --ILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT 802
+L L + G + I+ + E++ R++ + + K L L L T
Sbjct: 3583 QALLNGLELLKQTTGD-EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHST 3641
Query: 803 EDEEA-WIQETEPSATS--TYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKM 859
+E W+ + E S T + K AS+ + R + + + +++ + + E + +
Sbjct: 3642 HEELCTWLDKVEVELLSYETQVLKGEEASQAQM-RPKELKKEAKNNKALLDSLNEVSSAL 3700
Query: 860 VEEGHFAA-EDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAE-TWIRE 917
+E + A E + V N+ + ++ +++A + Q +AE +WI E
Sbjct: 3701 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITE 3760
Query: 918 KEP-IVDNTNYGADEEAAGALLKKHEAFLLDL----NSFGDSMKALRNQANACQQQQAAP 972
E ++ + +++ A L+ + F +++ + D +K+ AC +++
Sbjct: 3761 TEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQS 3820
Query: 973 VEGVAGEQRVMALYDF--QARSPREVTMKKGDVLTLLSSINKDWWKVEA-----ADHQGI 1025
++ +V+ YD Q S R + +++ L +N+ W E + Q I
Sbjct: 3821 MKKKL--DKVLKNYDTICQINSERYLQLERAQSL-----VNQFWETYEELWPWLTETQSI 3873
Query: 1026 VPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRS---LLDRAEERRRRLLQRY 1082
+ + L ++ + R+ I + + I+ ++ LL+ + + ++Y
Sbjct: 3874 ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKY 3933
Query: 1083 NEFLLAYEAGDMLEWIQEKKAENTGVELDDV----WELQKKFDEFQKDLNTNEPRLRDIN 1138
A D L ++ + V LD+ + K D+ + L RLR
Sbjct: 3934 -------VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPP 3986
Query: 1139 KVADDL--LFEGLLTPEGAQIRQE-LNSRWGSLQRLADEQRQLLG------SAHAVE--- 1186
++ ++ + E + + + E L + +L++ +E G SA AV+
Sbjct: 3987 SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKL 4046
Query: 1187 -------------VFHREAD--DTKEQIEKK-CQALSAA--------------DPGSDLF 1216
V REA D E EK C +S DPG D
Sbjct: 4047 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 4106
Query: 1217 SVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKM-ELNEAWEDLQ 1275
V+ Q E ++ L +++ I+ L + + + + ++ + ELN AW+ L
Sbjct: 4107 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLN 4166
Query: 1276 GRTKDRKESLNEA-QKFYLFLSKARDLQNWISSIGGMVSSQE-LAEDLTGIEILLERHQE 1333
KDR + L EA Q + + + +W+ GG ++S + DL ++ +E ++
Sbjct: 4167 KAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQ 4226
Query: 1334 HRADMEAEAPTFQALEDFSAELI------DSGHHASPEIEKKLQAVKLERDDLEKAWEKR 1387
+++ + + L + AEL+ +S H ++ L +KL D LE+ R
Sbjct: 4227 FKSEAYQQQIEMERL-NHQAELLLKKVTEESDKHT---VQDPLMELKLIWDSLEERIINR 4282
Query: 1388 K-KILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLD--SLEALMKKRDDLDKAIT 1444
+ K+ L L FQ D++ +W+ E L D ++E + K L +
Sbjct: 4283 QHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVL 4342
Query: 1445 AQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLD----RWKALKAQLIDERTKL-GDY 1499
A + + + LI E A EE A+ LQ L+ RW+ + + + +L G
Sbjct: 4343 AHQSTVEAVNKAGNDLI--ESSAGEE-ASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4399
Query: 1500 ANLKQFYRDLEELEEWISE----MLPT----ACDESYKDATNIQRKYLKHQTFAHEVDGR 1551
K F+ ++E+L++W+++ +L + E+ K+ N+ H + +
Sbjct: 4400 RQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV------HMEVCAAFEAK 4453
Query: 1552 SEQVHGVINLGNSLIECSACDGNEEAMKEQ-LEQLKEHWDHLLERTNDKGKKLNEA-SRQ 1609
E ++ G ++ + C + E +Q + LKE W+ + + N++ KL EA +
Sbjct: 4454 EETYKSLMQKGQQML--ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLA 4511
Query: 1610 QRFNTSIRDFEFWLSEAE-TLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNT 1668
F+ S++DF WL++AE TL + L + + +H++ E+ + + + +L+
Sbjct: 4512 MEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDK 4571
Query: 1669 LAEDL-LSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF-QFFQDLDDEE 1726
L S +V I +V R+ V + L +A QF +
Sbjct: 4572 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4631
Query: 1727 SWIEEKLIRVSSQ-DYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAV 1785
W+EE + S+ + D ++ L +HK + L A LK+K ++
Sbjct: 4632 EWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691
Query: 1786 GQEEIQL--RLAQFVEHWEKLKELAKARGLKLEESLEYL-QFMQNAEEEEAWINE-KNAL 1841
+ ++L L++ + W+ + + R KLEE+L + QF + W+ + L
Sbjct: 4692 ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4751
Query: 1842 AVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEES----QNK 1897
A + +L+ H+A + + + VQ + +++ + S Q +
Sbjct: 4752 AEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQ 4811
Query: 1898 EISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNG 1957
E+S++ E + + S + A Q E EF+ + W+A+ E +L+ +G
Sbjct: 4812 ELSTRWETVCALSISKQTRLEAALRQAE------EFHSVVHALLEWLAEAEQTLRFHGVL 4865
Query: 1958 ADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLK-R 2016
D D L L Q ++ L + T + D +++ H S + + +++ R
Sbjct: 4866 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4925
Query: 2017 WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLN 2076
+E++L + H+Q+L L ++L A W E + + V +
Sbjct: 4926 FEEVLAWAKQHQQRLASALAGLIAKQELLEALL----AWLQWAETTLTDKDKEVIPQEIE 4981
Query: 2077 EIRQLQKDHEDFLASLARAQAD 2098
E++ L +H+ F+ + R Q D
Sbjct: 4982 EVKALIAEHQTFMEEMTRKQPD 5003
Score = 194 bits (493), Expect = 9e-49
Identities = 436/2211 (19%), Positives = 894/2211 (40%), Gaps = 271/2211 (12%)
Query: 56 QVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTR 115
++ K D K +++KV+++T++ + ++ QK + + + R + ++
Sbjct: 2940 EIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQL 2999
Query: 116 EERFTMGHSAH--------EETKAHIEELRH--------LWDLLLELTLEKGDQLLRALK 159
+ ++G A+ + + ++ L+H DL++E + KG + L+
Sbjct: 3000 DIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDV-LLQ 3058
Query: 160 FQQYVQECADILEWIGDK-EAIATSVE-LGEDWERTEVLHKKFEDFQVEL--VAKEGRVV 215
+ QE + + + + +K + T ++ +G + +F +F EL +A GR
Sbjct: 3059 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3118
Query: 216 EVNQYANE---------------------------CAEENHPDLPLIQSKQNEVNAAWER 248
E Q E EE PDL I+ ++ +
Sbjct: 3119 ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK 3178
Query: 249 LRGLALQRQKALSNA--------ANLQRFKRDVTEAIQWIKEKEPV-LTSEDYGKDL--- 296
L A R++ + + L+ F + +A + + + PV + +E + L
Sbjct: 3179 LLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMF 3238
Query: 297 -VASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLT-LSHPSDAPQIQEMKEDLVSSWEH 354
V + +G ++++ + + + AK+ L H D D+ + W+
Sbjct: 3239 KVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD---------DVNARWKT 3289
Query: 355 IRALATSRYEKLQATYWY-HRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQ 413
+ R +LQ + RF + L WM + T + A++ P A +V+ + Q
Sbjct: 3290 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD-TEELVANQKPPS-AEFKVVKAQIQ 3347
Query: 414 QHKHEIDSYDDRFQSADETGQD--LVNANHEASDEVR--EKMEILDNNWTALLELWDERH 469
+ K DDR + + ++ + E +D+V+ +++ +LD+ W ALL + R+
Sbjct: 3348 EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN 3407
Query: 470 RQYEQC-LDFHLFYRDSEQVDSWMSRQEAFLEN-EDLGNSLGSAEALLQKHEDFEEAFTA 527
RQ E + F+ E ++ W++ E L N E +G E + +H+ E+
Sbjct: 3408 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3467
Query: 528 QEEKIITVDKTATKL-IGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQK 586
+ + L + D + +++ D ++EK+ +R LL+++L K
Sbjct: 3468 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3527
Query: 587 LY-EDSDDLKNWINK---KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQK 642
++ ED +L NW+N+ K +DY + L + + +V ++++ + K ++
Sbjct: 3528 IFGEDEVELMNWLNEVHDKLSKLSVQDYST-EGLWKQQSELRVLQEDILLRKQNVDQALL 3586
Query: 643 TGQEMIEGGHYASDNVTT---RLSEVASLWEELLEATKQKGTQLHEANQQLQ-FENNAED 698
G E+++ D V +L + + ++++ + + L +A Q + + E+
Sbjct: 3587 NGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEE 3644
Query: 699 LQRWLEDVEWQVTSEDYG--KGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEI 756
L WL+ VE ++ S + KG Q ++R L + A + +D L ++++ E+
Sbjct: 3645 LCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA-KNNKALLDSLNEVSSALLEL 3703
Query: 757 GHPDSKDIRARQ--ESLVC----RFEALKEPLATRKKKLLD--LLHLQLICRDTEDEEAW 808
RAR+ E +V R+ + + + T+K + +D +L Q + + E +W
Sbjct: 3704 -----VPWRAREGLEKMVAEDNERYRLVSDTI-TQKVEEIDAAILRSQQFDQAADAELSW 3757
Query: 809 IQETEPSATST---YLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHF 865
I ETE S L +D +++ L + I H+ I ++ + G+K++
Sbjct: 3758 ITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDIIDDLVKSGHKIMTA--C 3813
Query: 866 AAEDVASRVKSLNQ---NMESLRARAARRQNDLE-ANVQFQQYLADLHEAETWIREKEPI 921
+ E+ S K L++ N +++ + R LE A Q+ E W+ E + I
Sbjct: 3814 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI 3873
Query: 922 VDNTNYGA-----------DEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQA 970
+ A + L+ +H+ + +N G + L
Sbjct: 3874 ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL------------ 3921
Query: 971 APVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAA--DHQGIVPA 1028
+P EG + +++ +A ++ +V + + +S + K++ + IV
Sbjct: 3922 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3981
Query: 1029 VYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRL--LQRYNEFL 1086
+ E + ++ E N++ E+++ Y +L R EE R +
Sbjct: 3982 LRQPPSISAEVEKIKEQISENK-NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 4040
Query: 1087 LAYEAGDMLEWIQEK---KAENTGVELDDVWELQKKF--------------DEFQKDLN- 1128
+ D + +I E E +L DV EL +KF +F +DL
Sbjct: 4041 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED 4100
Query: 1129 -------------TNEPRLRDINKVADDL---------LFEGLLTPEGAQIRQ---ELNS 1163
E +I+ + ++L L P+ +++ ELNS
Sbjct: 4101 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4160
Query: 1164 RWGSLQRLADEQRQLLGSAHAVEVFHREA-DDTKEQIEKKCQALSAADP-GSDLFSVQAL 1221
W SL + ++ L A V +++ + ++ L++ P G+DL +V+
Sbjct: 4161 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4220
Query: 1222 QRRHEGFERDLVPLGDKVTILGETAERLSESHPDATED--LQRQKMELNEAWEDLQGRTK 1279
+ F+ + ++ L AE L + + ++ +Q MEL W+ L+ R
Sbjct: 4221 IEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERII 4280
Query: 1280 DRKESLNEAQKFYLFLSKARD-LQNWISSIGGMVSSQE-LAEDLTGIEILLERHQEHRAD 1337
+R+ L A A D L W++ G++S Q+ + D IEI L +H + D
Sbjct: 4281 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQND 4340
Query: 1338 MEAEAPTFQALEDFSAELIDS--GHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCL 1395
+ A T +A+ +LI+S G AS ++ KL+ + ++ + E+RK+ LD L
Sbjct: 4341 VLAHQSTVEAVNKAGNDLIESSAGEEAS-NLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4399
Query: 1396 -ELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDK----AITAQEGKI 1450
+ + F G + ++ W+ E L + L L K++ ++ A A+E
Sbjct: 4400 RQAKGFHGEIEDLQQWLTDTERHLLAS--KPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4457
Query: 1451 TDLEHFAESLIAD-EHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLK-QFYRD 1508
L + ++A A+ I + + ++W++++ +L + +TKL + NL +F+
Sbjct: 4458 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4517
Query: 1509 LEELEEWISEMLPTACDESYKDAT--NIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLI 1566
L++ W+++ T S + + +H+ FA+EV+ EQ+ + G L
Sbjct: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
Query: 1567 ECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEA-SRQQRFNTSIRDFEFWLSE 1625
S + +K L ++ W+ +++R ++G+ L++A R ++F+ + WL E
Sbjct: 4578 YFSQKQ-DVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEE 4636
Query: 1626 AETLLAMK-DQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQI 1684
+E L + + A D L +H+ ++ + A+ N L T D
Sbjct: 4637 SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEK-TSLADDN 4695
Query: 1685 VKKKDNVNK---RFLNVQELAAAHHEKLKEAYALF-QFFQDLDDEESW---IEEKLIRVS 1737
+K D +++ ++ + + KL+EA QF L W +E +L
Sbjct: 4696 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL--AE 4753
Query: 1738 SQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQF 1797
Q D+ V NL+ HK + EL ++Q + A +L + + +++++ +
Sbjct: 4754 DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQEL 4813
Query: 1798 VEHWEKLKELAKARGLKLEESLEYL-QFMQNAEEEEAWINE-KNALAVRGDCGDTLAATQ 1855
WE + L+ ++ +LE +L +F W+ E + L G D A +
Sbjct: 4814 STRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALR 4873
Query: 1856 SLLMKHEALENDFAVHETRVQNVCAQGEDIL----------------------NKVLQEE 1893
+L+ +H+ + G+ +L +VL
Sbjct: 4874 TLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWA 4933
Query: 1894 SQNKE-ISSKIEALNEKTPSLAKAIAAWKLQLE---DDYAFQEFNWKADVVEAWIADKET 1949
Q+++ ++S + L K L +A+ AW E D + + + V+A IA+ +T
Sbjct: 4934 KQHQQRLASALAGLIAK-QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQT 4992
Query: 1950 SLKTNGNGADLGDFLTLLAKQDTLD-ASLQSF---------QQERLPEITDLKDKLISAQ 1999
++ D +T K+ D +SLQS ++R P S
Sbjct: 4993 FMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFP----ASSLYPSGS 5048
Query: 2000 HNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAH 2050
Q + R L+ +W+Q+ + R+KL + L + E+L EFA+
Sbjct: 5049 QTQIETKNPRVNLLVSKWQQVWLLALERRRKLND---ALDRLEEL-REFAN 5095
Score = 156 bits (395), Expect = 2e-37
Identities = 445/2411 (18%), Positives = 946/2411 (39%), Gaps = 288/2411 (11%)
Query: 39 KERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTN-----IQGKYQK 93
K+++AE KL LQ + ++ + +W+ +K+N K + P ++ + ++
Sbjct: 2416 KDKIAELNTKLSK---LQKAQEESSAMMQWL-QKMNKTATKWQQTPAPTDTEAVKTQVEQ 2471
Query: 94 HQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEET--KAHIEELRHLWDLLLELTLEKG 151
++S EAE++ + EL+ E E K + E+ W L +LT+++
Sbjct: 2472 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2531
Query: 152 DQLLRALK-FQQYVQECADILEWIGDKEAIATSV-ELGEDWERTEVLHKKFEDFQVELVA 209
+L + Q+ A + +W+ +KE + + + L D ++ + E
Sbjct: 2532 QKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFAT 2591
Query: 210 KEGRVVEVNQYANECAEENHPDLPL---IQSKQNEVNAAWERLRGLALQR----QKALSN 262
++ + ++ D L ++ + V W+ L G R +A+
Sbjct: 2592 RKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK 2651
Query: 263 AANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKE 322
+ Q R +++ + + K + D + + + + +++ + ++K
Sbjct: 2652 STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQ--LETAQKMKQEIQQEKKQIKV 2709
Query: 323 LCAKAEKLTLSHPSD--APQIQEMKEDLVSSWEHIRALATSRYEKLQ-ATYWYHRFSSDF 379
A E L+ + ++ E ++ S++ + A + + LQ A H+F
Sbjct: 2710 AQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2769
Query: 380 DELSGWMNEKTAAINADE-LPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN 438
+ W++ K N + + E L+ H+ + + ++ G++L+
Sbjct: 2770 RDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL- 2828
Query: 439 ANHEASDEVREKMEI--LDNNWTALLELWDERHRQYEQCLDFHLFYRDS-EQVDSWMSRQ 495
+ S++ ++++ + NW + ER + ++ L+ L Y++ E + W+ +
Sbjct: 2829 LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2888
Query: 496 EAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555
+ LE E + K + ++ + ++ TA L+ D E +
Sbjct: 2889 QNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2948
Query: 556 IRDGLLARRDALREKAATRRRLLKESLLLQKLYED-SDDLKNWINKKKKLADDEDYKDIQ 614
L+ + D + E+ +++ L+ K +++ S + K + K+ D D Q
Sbjct: 2949 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQ 3008
Query: 615 NLKSR-VQKQQVFEKELAVNKTQLENIQKTGQEMI--EGGHYASDNVTTRLSEVASLWEE 671
++ + Q +K L K Q++ ++ Q+++ + +V ++ +A
Sbjct: 3009 AYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHST 3068
Query: 672 LLEATKQKGTQLHEANQQL-QFENNAEDLQRWLEDVEWQVTS--------EDYGKGLAEV 722
L + +K + L Q + F+N ++ + + ++ S E K +
Sbjct: 3069 LSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETI 3128
Query: 723 QNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPL 782
+ L+K LE A+ A D + + EE PD I+ E+L + L +
Sbjct: 3129 KAFLKK---LE-ALMASNDNANKTCKMMLATEETS-PDLVGIKRDLEALSKQCNKLLDRA 3183
Query: 783 ATRKKKLLDLL-HLQLICRDTEDEEAWIQETEPSATSTY-LGKDLIASKKLLNRHRVIL- 839
R++++ + L+ ++ +Q+ E S +G + + LN +V
Sbjct: 3184 QAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQK 3243
Query: 840 ENIASHEPRIQEITERGNKMVEEGHFAA---------EDVASRVKSLNQNMESLRAR--- 887
E I + + Q++ G +++ + +DV +R K+LN+ + A+
Sbjct: 3244 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3303
Query: 888 ----AARRQNDLEA------------------NVQFQQYLADLHEAETWIR---EKEPIV 922
R Q+ LE+ + +F+ A + E + R +++ V
Sbjct: 3304 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV 3363
Query: 923 DNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRV 982
+ ++ A A L L+ +AL N+A +Q +EG++ V
Sbjct: 3364 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQ----LEGIS----V 3415
Query: 983 MALYDFQARSPRE---VTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEF 1039
+A + P T++K V + + A H+ + + +
Sbjct: 3416 VAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQA 3475
Query: 1040 PMLPQR-----RREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRY-NEFLLAYEAGD 1093
+ Q RE+ + + + + Y + +++ R L Q N + + +
Sbjct: 3476 VSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVE 3535
Query: 1094 MLEWIQEKKAENTGVELDD-----VWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEG 1148
++ W+ E + + + + D +W+ Q + Q+D+ LR N D L G
Sbjct: 3536 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI-----LLRKQN--VDQALLNG 3588
Query: 1149 L-----LTPEGAQIRQE----LNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQI 1199
L T + I Q+ + +R+ + +L+ + + L A + R T E++
Sbjct: 3589 LELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA---RRLHSTHEEL 3645
Query: 1200 EKKCQALSAADPGSDLFSVQAL--------QRRHEGFERDLVPLGDKVTILGETAERLSE 1251
C L + + Q L Q R + +++ + L E + L E
Sbjct: 3646 ---CTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE 3702
Query: 1252 SHP-DATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQ-NWISSIG 1309
P A E L++ E NE + + + E ++ A +A D + +WI+
Sbjct: 3703 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWIT--- 3759
Query: 1310 GMVSSQELAEDLTGI-EILLERHQEHRADMEAEAPTFQAL--EDFSAELIDSGHH---AS 1363
E + L + +I LE+ Q + T + L +D +L+ SGH A
Sbjct: 3760 ------ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3813
Query: 1364 PEIEKKLQAVKLER-----DDLEKAWEKRKKILDQCLEL-QMFQGNCDQVESWMVAREN- 1416
E EK+ KL++ D + + +R L++ L F +++ W+ ++
Sbjct: 3814 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI 3873
Query: 1417 ------------SLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADE 1464
+LR + E + + + +DK + ++ +L I ++
Sbjct: 3874 ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK-MNKTGPQLLELSPGEGFSIQEK 3932
Query: 1465 HYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTAC 1524
+ A + + ++++ + + + I + T+ D + Q LE + E + + +
Sbjct: 3933 YVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILESLERIVERLRQPPSISA 3990
Query: 1525 D-----ESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMK 1579
+ E + N+ K Q + R E++ + G + + SA +A++
Sbjct: 3991 EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM--IARSGGTDKDISA-----KAVQ 4043
Query: 1580 EQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQA--- 1636
++L+Q+ W+++ ++ KL + +FW ++ +KD
Sbjct: 4044 DKLDQMVFIWENIHTLVEEREAKLLDVMELAE--------KFWCDHMSLIVTIKDTQDFI 4095
Query: 1637 RDLASAG---NLLKKHQ----LLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK- 1688
RDL G +++K+ Q + E+ ++ L + L +L+++ IVKK
Sbjct: 4096 RDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSI 4155
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAY-ALFQFFQDLDDEESWIEEKLIRVSSQD-YGRDLQ 1746
D +N + ++ + +KL+EA A Q+ L W++ +++S G DL+
Sbjct: 4156 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4215
Query: 1747 GVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEE--IQLRLAQFVEHWEKL 1804
V+ +++ K+ + E + ++ + AE L K ++ +Q L + W+ L
Sbjct: 4216 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4275
Query: 1805 KELAKARGLKLEESLEYL-QFMQNAEEEEAWINE-KNALAVRGDCGDTLAATQSLLMKHE 1862
+E R KLE +L L QF +E AW+ + L+ + G A + L KH
Sbjct: 4276 EERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH 4335
Query: 1863 ALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKL 1922
L+ND H++ V+ V G D++ EE+ N + +K+E LN++ ++ + K
Sbjct: 4336 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN--LQNKLEVLNQRWQNVLEKTEQRKQ 4393
Query: 1923 QLEDDYAFQE---FNWKADVVEAWIADKETSLKTNGNGADLGD------------FLTLL 1967
QL D A ++ F+ + + ++ W+ D E L + L +
Sbjct: 4394 QL--DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFE 4451
Query: 1968 AKQDTLDASLQSFQQ--ERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASA 2025
AK++T + +Q QQ R P+ SA+ N I++ L ++WE +
Sbjct: 4452 AKEETYKSLMQKGQQMLARCPK---------SAETN----IDQDINNLKEKWESV----- 4493
Query: 2026 VHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDH 2085
KL E++ L++A +L +EF + NW + E+ L+ + + Q D
Sbjct: 4494 --ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDE 4551
Query: 2086 EDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVL----ERTWKHLSDIIEER 2141
A+ + + ++ELD+ L S + ++ L + W+ + + ER
Sbjct: 4552 HKVFANEVNSHRE--QIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVER 4609
Query: 2142 EQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSL--LKETGTLESQLEAN 2199
+ L ++AR + ++F + S ++W LE LD L + +++QL +
Sbjct: 4610 GRSL--DDAR-----KRAKQFHEAWSKLMEW-LEESEKSLDSELEIANDPDKIKTQLAQH 4661
Query: 2200 KRKQKEIQAMK----------RQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLG 2249
K QK + A R L + L D D L LD S L +WD +
Sbjct: 4662 KEFQKSLGAKHSVYDTTNRTGRSLKEKTSLAD---DNLKLDDMLSE--LRDKWDTICGKS 4716
Query: 2250 LRMQHNLEQQI 2260
+ Q+ LE+ +
Sbjct: 4717 VERQNKLEEAL 4727
Score = 130 bits (326), Expect = 2e-29
Identities = 246/1229 (20%), Positives = 521/1229 (42%), Gaps = 154/1229 (12%)
Query: 22 EEIQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIME---KVNILT 77
E +++ E RY+ + + ++ ++++ + Q F + AD WI E K+ L
Sbjct: 3710 EGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLG 3769
Query: 78 DKSYE-DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEET-KAHIEE 135
D E D T+ Q + QK + E+ ++ +L K+ + T +++ K +++
Sbjct: 3770 DIRLEQDQTSAQLQVQK--TFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK 3827
Query: 136 LRHLWDLLLELTLEKGDQLLRALKF-QQYVQECADILEWIGDKEAIATSVELGEDWERTE 194
+ +D + ++ E+ QL RA Q+ + ++ W+ + ++I + +L E
Sbjct: 3828 VLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS--QLPAPALEYE 3885
Query: 195 VLHKKFEDFQV--ELVAK-EGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRG 251
L ++ E+ + EL+A+ + + ++N+ + E + + IQ K + + +++
Sbjct: 3886 TLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3945
Query: 252 LALQRQKALSNAAN-------------------LQRFKRDVTEAIQWIKEKEPVLTSEDY 292
+R AL A + ++R ++ + + + K KE + +++
Sbjct: 3946 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNV 4005
Query: 293 GKDLVASEGLFHSHKGL-ERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSS 351
D+ + L+ + K E +A K++ AKA +Q+ + +V
Sbjct: 4006 SVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA-------------VQDKLDQMVFI 4052
Query: 352 WEHIRALATSRYEKL-QATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLD 410
WE+I L R KL +F D L + + I E P G + +
Sbjct: 4053 WENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP----GIDPSVV 4108
Query: 411 RHQQH-----KHEIDSYDDRFQSADETGQDLVNANHEASDE-VREKMEILDNNWTALLEL 464
+ QQ + EID + G +L+ A E V++ ++ L++ W +L +
Sbjct: 4109 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4168
Query: 465 WDERHRQYEQCLDFHLFYRDSEQ-VDSWMSRQEAFLEN-EDLGNSLGSAEALLQKHEDFE 522
W +R + E+ + + Y+D Q V W+ L + +G L + + +++ + F+
Sbjct: 4169 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK 4228
Query: 523 EAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARR---DALREKAATRRRLLK 579
Q+ ++ ++ A L+ +S+ ++D L+ + D+L E+ R+ L+
Sbjct: 4229 SEAYQQQIEMERLNHQAELLLKKVTEESDK-HTVQDPLMELKLIWDSLEERIINRQHKLE 4287
Query: 580 ESLLLQKLYEDS-DDLKNWINKKKKLADDEDYK--DIQNLKSRVQKQQVFEKELAVNKTQ 636
+LL ++ + D+L W+ + L ++ D + ++ + K V + ++ +++
Sbjct: 4288 GALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQST 4347
Query: 637 LENIQKTGQEMIEG--GHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FE 693
+E + K G ++IE G AS N+ +L + W+ +LE T+Q+ QL A +Q + F
Sbjct: 4348 VEAVNKAGNDLIESSAGEEAS-NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFH 4406
Query: 694 NNAEDLQRWLEDVEWQVTSEDYGKGLAEV-QNRLRKHGLLESAVAARQDQVDILTDLAAY 752
EDLQ+WL D E + + GL E + +L H + +A A+++ L
Sbjct: 4407 GEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQ 4466
Query: 753 FEEIGHPDSKDIRARQE--SLVCRFEALKEPLATRKKKLLDLLHLQLICRDT-EDEEAWI 809
P S + Q+ +L ++E+++ L RK KL + L+L + ++ +D W+
Sbjct: 4467 MLA-RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWL 4525
Query: 810 QETEPS---ATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERG---------- 856
+ E + A+ L D + + ++ H+V + SH +I E+ + G
Sbjct: 4526 TQAEQTLNVASRPSLILDTVLFQ--IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQ 4583
Query: 857 --------------------NKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE 896
++VE G + +D R K ++ L + L+
Sbjct: 4584 DVVLIKNLLISVQSRWEKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4642
Query: 897 ANVQ-------FQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLN 949
+ ++ + LA E + + K + D TN G LK+ + D
Sbjct: 4643 SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN------RTGRSLKEKTSLADDNL 4696
Query: 950 SFGDSMKALRNQANAC------QQQQAAPVEGVAGE--QRVMALYDFQARSPREVTMKK- 1000
D + LR++ + +Q + +G+ + AL D+ R ++ +
Sbjct: 4697 KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP 4756
Query: 1001 --GDVLTLLSSI-NKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQ 1057
GD+ +++ I N ++ E V A ++R A + L + R++ + +
Sbjct: 4757 VHGDIDLVMNLIDNHKAFQKELGKRTSSVQA--LKRSARE----LIEGSRDDSSWVKVQM 4810
Query: 1058 EQIENQYRSLLDRAEERRRRL---LQRYNEFLLAYEAGDMLEWIQEKKAENT----GVEL 1110
+++ ++ ++ + ++ RL L++ EF A +LEW+ E AE T GV
Sbjct: 4811 QELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA--LLEWLAE--AEQTLRFHGVLP 4866
Query: 1111 DDVWELQKKFDEFQKDLNTNEPRLRDINK 1139
DD L+ D+ ++ + E + ++NK
Sbjct: 4867 DDEDALRTLIDQHKEFMKKLEEKRAELNK 4895
Score = 125 bits (314), Expect = 5e-28
Identities = 431/2270 (18%), Positives = 886/2270 (39%), Gaps = 316/2270 (13%)
Query: 273 VTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTL 332
V + + W+ E + L ++G DL + E +HK + R + +KE AK ++ +
Sbjct: 608 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQM 665
Query: 333 SHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKT-- 390
+ P +++ ++ + L TSR ++ ++ S +EL W+NEK
Sbjct: 666 TAPLKLTYAEKLHR---LESQYAKLLNTSRNQERHLDTLHNFVSRATNELI-WLNEKEEE 721
Query: 391 -AAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVRE 449
A + E T++A + D H + E+D ++ +S E + L+ NH A +
Sbjct: 722 EVAYDWSERNTNIARKK---DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEA 778
Query: 450 KMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENE---DLGN 506
+ W+ +L+L + ++ + F+ D+++ ++ + ++ + D +
Sbjct: 779 YRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS 838
Query: 507 SLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSE-------NIKAI--- 556
S+ E L+Q+ + +E + I + A +I +S+ IKAI
Sbjct: 839 SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDY 898
Query: 557 ---------RDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADD 607
D + ++ R K E+++ + K ++ ++ +
Sbjct: 899 RQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--E 956
Query: 608 EDYKDIQNL--KSRVQKQQVFEKELAVNKTQLENIQKTG----QEMIEGGHYASDNVTTR 661
+ Y+++ L +S + + V +N +++ I+ + + M+ G H
Sbjct: 957 QQYQNVLTLWHESHINMKSVVSWHYLIN--EIDRIRASNVASIKTMLPGEHQQV------ 1008
Query: 662 LSEVASLWEELLEATKQKGTQLHEANQQLQFENNA--EDLQRWLEDVEWQVTSED-YGKG 718
LS + S +E+ LE +++ QL+ E N + Q L+ E + E Y
Sbjct: 1009 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 1068
Query: 719 LAEVQN-RLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEA 777
++EV+N RLR LE+ +D+ ++ + E +S QE L E
Sbjct: 1069 ISEVRNIRLR----LENC----EDR--LIRQIRTPLERDDLHESVFRITEQEKLKKELER 1118
Query: 778 LKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY-LGKDLIASKKLLNRHR 836
LK+ L T K + + + + Y + I K +N
Sbjct: 1119 LKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVN--- 1175
Query: 837 VILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQ---N 893
++L+N + E ++ K+ EE A+ + +++L ++ R+ ++ +
Sbjct: 1176 LVLKNTQAAEALVKLYE---TKLCEEEAVIAD--KNNIENLISTLKQWRSEVDEKRQVFH 1230
Query: 894 DLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAF-------LL 946
LE +Q + ++D E + KE +D + +E A L+++ + L
Sbjct: 1231 ALEDELQKAKAISD----EMFKTYKERDLD---FDWHKEKADQLVERWQNVHVQIDNRLR 1283
Query: 947 DLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTL 1006
DL G S+K R+ + ++ V QR + + Q + + + + L
Sbjct: 1284 DLEGIGKSLKYYRDTYHPLDDW----IQQVETTQR--KIQENQPENSKTLATQLNQQKML 1337
Query: 1007 LSSINKDWWKVE-----AADHQGIVPAVYVRRLAH-------DEFPMLPQRRREEPGNIT 1054
+S I K++ A + V ++ + + + P+ +R + I
Sbjct: 1338 VSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII 1397
Query: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVW 1114
Q + +Y +L+ L+ +Y +F AGD L+ ++E E +E ++
Sbjct: 1398 QEFMDLRTRYTALV--------TLMTQYIKF-----AGDSLKRLEE---EEKSLE-EEKK 1440
Query: 1115 ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADE 1174
E +K E QK ++ L+D K + ++ E ++E S +LQ +
Sbjct: 1441 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE--ALQTI--- 1495
Query: 1175 QRQLLGSAHAVEVFHREADDTKEQI------------EKKCQALSAADPGSDLFSVQALQ 1222
QL + H ++ E ++ ++Q+ E Q + G + +
Sbjct: 1496 --QLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVA 1553
Query: 1223 RRHEGFERDLVPLGDKVTILGETAERLSESHP-----DATEDLQRQKMELNEAWEDLQGR 1277
R + ++ L + D +L +T RL D T +L++ + + E +D+QG
Sbjct: 1554 ERQQEYKEKLQGICD---LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGS 1610
Query: 1278 TKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRAD 1337
+ E + + F ++ +S + Q+L E E L + ++ + +
Sbjct: 1611 AQALAEVVKNTENF------LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE 1664
Query: 1338 MEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLEL 1397
++ T E + + +IE L + D E+A K K++++Q
Sbjct: 1665 LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQ--NG 1722
Query: 1398 QMFQ--------GNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGK 1449
FQ G D+V ++ E + ++ ++L +K + I +Q
Sbjct: 1723 THFQEGDGKSAIGEEDEVNGNLL--ETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQA 1780
Query: 1450 ITDLEHFAESLIADE-HYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYAN-----LK 1503
+ A+ L+ + Y E +LQ+ + K + E K + L+
Sbjct: 1781 VIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELE 1840
Query: 1504 QFYRDLEELEEWI--SEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINL 1561
+F D E E W+ SE + D + K + ++F+ +V + +
Sbjct: 1841 KFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITIS 1900
Query: 1562 GNSLIE----CSACDGNE-------EAMKEQLEQLKEHWDHLLERTNDKGKKLNE-ASRQ 1609
GN ++E CS DG + ++ +L+ + + L + N G L + +
Sbjct: 1901 GNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY 1960
Query: 1610 QRFNTSIRDFEFWLSEAETLLA---MKDQARDLASAGNLLKKHQLLEREMLAREDALKDL 1666
Q + + L E + + A D + L++ + L+ ++ +++ A++ L
Sbjct: 1961 QHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKL 2020
Query: 1667 NTLAEDLLSS-GTF--NVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQD-L 1722
AE LL + G+ + I K D++ R+ ++ + +EKL+ QD L
Sbjct: 2021 KKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGL 2080
Query: 1723 DDEESWIEEKLIRVSSQDYGR---DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL 1779
D+ W+ + S ++ G+ + +Q+++ K+ LE ++ + +I + + +K
Sbjct: 2081 DEMLDWMGN--VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKF 2138
Query: 1780 KD-----KAAVGQEEIQLRLAQFVEHWEKLKE-LAKARGLKLEESLEYLQFMQNAEEEEA 1833
+ A+ Q +++ A+F E K KE LAK LK + L F +E+ +
Sbjct: 2139 METTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL----FENLSEKLQT 2194
Query: 1834 WINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEE 1893
++ K D S M+ ++F H+ ++ + + ++I + L +
Sbjct: 2195 FLETKTQALTEVDVPGKDVTELSQYMQEST--SEFLEHKKHLEVLHSLLKEISSHGLPSD 2252
Query: 1894 -----SQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKE 1948
+ +S K + + + +A+ + + QL+ AFQ +++WI KE
Sbjct: 2253 KALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLD---AFQVL---VKSLKSWI--KE 2304
Query: 1949 TSLKT-----NGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKD------KLIS 1997
T+ K + DLG L +DT LQ + PEI + + LIS
Sbjct: 2305 TTKKVPIVQPSFGAEDLGKSL-----EDT--KKLQEKWSLKTPEIQKVNNSGISLCNLIS 2357
Query: 1998 AQHNQSKAI-------------------EERYA--ALLKRWEQLLEAS-------AVHRQ 2029
A +KAI EE +A L + + + S + +
Sbjct: 2358 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2417
Query: 2030 KLLE---KQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHE 2086
K+ E K LQKA++ ++SA+ W +KM + ++ + + ++ E
Sbjct: 2418 KIAELNTKLSKLQKAQE-------ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVE 2470
Query: 2087 DFLASLARAQADFKCLLELDQQIKAL-----GVPSSPYTWLTVEVLERTWKHLSDIIEER 2141
+ A + + + EL ++ L P +P + ++ W+ L+ + +R
Sbjct: 2471 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2530
Query: 2142 EQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYF-LDGSLLKETGTLESQLEANK 2200
+Q+L+ E + + F+ + + QW++E + G L + L +Q + +
Sbjct: 2531 QQKLE-ESSNNLTQFQTVE------AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2583
Query: 2201 RKQKEIQAMKRQLTKIVDLGDNL-----EDALILDI-KYSTIGLAQQWDQLY-QLGLRMQ 2253
+E K Q ++ G + ED + I K + Q+WD L QL R
Sbjct: 2584 ILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCD 2643
Query: 2254 HNLEQQIQAKDIKGVS-EETLKEFSTIYKHFDENLTGRL---THKEFRSCLRGLNYYLPM 2309
++Q I +K + L+ S D L+ L TH + + + L M
Sbjct: 2644 W-IDQAI----VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN--QQLETAQKM 2696
Query: 2310 VEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENI-KSSDEIE 2358
+E + E K K A+ V E+Y + ++ E I KS ++E
Sbjct: 2697 KQEIQQEKKQIKVAQALCEDLSALVK-EEYLKAELSRQLEGILKSFKDVE 2745
Score = 124 bits (312), Expect = 9e-28
Identities = 433/2368 (18%), Positives = 888/2368 (37%), Gaps = 379/2368 (16%)
Query: 6 KETVVESSGPKVLETAEEIQERRQEV---LTRYQSFK----ERVAERGQKLEDSYHLQVF 58
K ++SS +++ +++ R + +T+Y F +R+ E + LE+ V
Sbjct: 1385 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVE 1444
Query: 59 KRDADDLGKWIMEKVNILTD--KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKT-- 114
K A +L KW+ L D K+ + P + K + E+ TK +SE +T
Sbjct: 1445 K--AKELQKWVSNISKTLKDAEKAGKPP------FSKQKISSEEISTKKEQLSEALQTIQ 1496
Query: 115 ---REERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADIL 171
+ M E + ++ L+ ++LL +LK Q Q D+
Sbjct: 1497 LFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS----------ESLKQLQESQTSGDVK 1546
Query: 172 EWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPD 231
+++ +A ER + +K + L E R++ + + +
Sbjct: 1547 V---EEKIVA---------ERQQEYKEKLQGICDLLTQTENRLIGHQEAF--MIGDGTVE 1592
Query: 232 LPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSED 291
L QSKQ E+ + ++G A + + N N ++KE L+ ED
Sbjct: 1593 LKKYQSKQEELQ---KDMQGSAQALAEVVKNTEN-------------FLKENGEKLSQED 1636
Query: 292 YGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSS 351
A++ K+ E K E+L L ++ ++
Sbjct: 1637 K---------------------ALIEQKLNEAKIKCEQLNLKAEQSKKELDKV------- 1668
Query: 352 WEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411
+ EK+ A + + L W++ N D+ ++ AG
Sbjct: 1669 ---VTTAIKEETEKVAAVKQLEESKTKIENLLDWLS------NVDK-DSERAG------- 1711
Query: 412 HQQHKHEIDSYDDRFQSADETG----QDLVNANHEASDEVREKMEILDNNWTALLELWDE 467
+HK I+ FQ D +D VN N +D + +N L + + +
Sbjct: 1712 -TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN----LNQQYQK 1766
Query: 468 RHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTA 527
Q+E+ + H Q + + SA+ LL+K + +
Sbjct: 1767 VKAQHEKIISQH---------------QAVIIATQ-------SAQVLLEKQGQY---LSP 1801
Query: 528 QEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKL 587
+E++ + + K+ HY++ ++ EK L+E L +K
Sbjct: 1802 EEKEKLQKNMKELKV----HYETALAES-------------EKKMKLTHSLQEEL--EKF 1842
Query: 588 YEDSDDLKNWINKKKKLADDEDY--KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQ 645
D + ++W+ + ++ ++ + DI L +++++Q+ F +++ +K L I +G
Sbjct: 1843 DADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGN 1902
Query: 646 EMIEGGHYASDN-------------VTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ- 691
++E S V +L + L G L + + Q
Sbjct: 1903 RVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQH 1962
Query: 692 FENNAEDLQRWLEDVEWQVT---SEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTD 748
+E+ + L L+ E + SE +Q +L + L+ ++++Q V+ L
Sbjct: 1963 YEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKK 2022
Query: 749 LAAYFEEIGH---PDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDE 805
A + P DI+ + +V R+E L + + R +KL L L +D DE
Sbjct: 2023 TAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2082
Query: 806 EA-WIQETEPSATST-YLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEG 863
W+ E S + + A + +++++ ++ ++IA + I + E+ K +E
Sbjct: 2083 MLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETT 2142
Query: 864 HFAAEDVASRVKSLNQNMESLRARAAR----------RQNDLEANVQFQQYLADLHEAET 913
S SL M+ L AR + + +L+ V+ + L++ + +T
Sbjct: 2143 D------PSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE--KLQT 2194
Query: 914 WIREKEPIVDNTNY-GADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQ--ANACQQQQA 970
++ K + + G D +++ + L+ + + +L + ++ +A
Sbjct: 2195 FLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA 2254
Query: 971 APVEGVAGEQRVMALYDFQARSPREVT---MKKGDVLTLLSSINKDWWKVEAADHQGIVP 1027
+E + + + +E ++ D +L K W K VP
Sbjct: 2255 LVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKK----VP 2310
Query: 1028 AVYVRRLAHDEFPMLPQRRR--EEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEF 1085
V A D L ++ E+ T +++ N SL + + +
Sbjct: 2311 IVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA-----VTTPAKA 2365
Query: 1086 LLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLL 1145
+ A ++G + E T ++ W K L + + + DI+ +DL
Sbjct: 2366 IAAVKSGGAV-----LNGEGTATNTEEFWA--------NKGLTSIKKDMTDISHGYEDL- 2411
Query: 1146 FEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQA 1205
GLL + ELN++ LQ+ +E ++ +++ K
Sbjct: 2412 --GLLLKDKIA---ELNTKLSKLQKAQEESSAMM--------------QWLQKMNKTATK 2452
Query: 1206 LSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKM 1265
+D +V+ +++ FE +L +KV L + L E +PD E + ++M
Sbjct: 2453 WQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQM 2512
Query: 1266 --ELNEAWEDLQGRTKDRKESLNE-AQKFYLFLSKARDLQNW-------ISSIGGM-VSS 1314
E++ W++L T DR++ L E + F + L+ W +S +G + +
Sbjct: 2513 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP 2572
Query: 1315 QELAEDLTGIEILLERHQEHRADMEAEAPTFQAL-----EDFSAELIDSGHHASPEIEKK 1369
L ++ILL+ + E Q + ED S I ++++
Sbjct: 2573 NMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGI---------VKEQ 2623
Query: 1370 LQAVKLERDDLEKAWEKRKKILDQCL-ELQMFQGNCDQVESWMVARENSLRSDDKSSL-- 1426
L AV + D L R +DQ + + +Q + + +N L S S
Sbjct: 2624 LAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP 2683
Query: 1427 DSLEALMKKRDDLDKAITAQEGKITDLEHFAESL--IADEHYAKEEIATRLQRVLDRWKA 1484
D++ ++ + + I ++ +I + E L + E Y K E++ +L+ +L +K
Sbjct: 2684 DAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKD 2743
Query: 1485 LKAQLIDERTKL-GDYANLKQFYRDLEELEEWISEMLPTACDESYKD-----ATNIQRKY 1538
++ + + L A+ QF + + + W L T +E K ++
Sbjct: 2744 VEQKAENHVQHLQSACASSHQFQQMSRDFQAW----LDTKKEEQNKSHPISAKLDVLESL 2799
Query: 1539 LK-HQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE-AMKEQLEQLKEHWDHLLERT 1596
+K H+ F+ + +S I G +L+ G+E+ A++ QL +K +WD ++
Sbjct: 2800 IKDHKDFSKTLTAQSHMYEKTIAEGENLL--LKTQGSEKAALQLQLNTIKTNWDTFNKQV 2857
Query: 1597 NDKGKKLNEA-SRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLERE 1655
++ KL E+ + ++ + W+ + + L D A N + K + L++E
Sbjct: 2858 KERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKE 2917
Query: 1656 MLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYAL 1715
M ++ LN A LLS + + + + ++ ++ V E + L+
Sbjct: 2918 MDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK 2977
Query: 1716 FQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775
F+ FQ++ E + +L Q D G Q K+ + A+++ +D+
Sbjct: 2978 FKEFQEVSKES---KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDL 3034
Query: 1776 AEKLKDKAAV------GQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829
A++L V G ++ L++ + L + + LE L+ + QN
Sbjct: 3035 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3094
Query: 1830 EE-----EAWINEKNALAVRGDCGDTL----AATQSLLMKHEAL--ENDFAVHETRVQNV 1878
E + +E +++A G +TL ++ L K EAL ND A ++
Sbjct: 3095 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM-- 3152
Query: 1879 CAQGEDILNKVLQEESQNKEISSK--IEALNEKTPSLAKAIAAWKLQLEDDY-AFQEFNW 1935
+ EE+ + K +EAL+++ L A + Q+E +EF
Sbjct: 3153 ----------LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYS 3202
Query: 1936 KADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDK- 1994
K + E ++ G + + +T++ L F+ + EI L+ K
Sbjct: 3203 KLKEFSILLQKAEEHEESQG---------PVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3253
Query: 1995 ---------LI--SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAED 2043
LI +A+ ++ +E + RW+ L +K+ ++ LQ+A
Sbjct: 3254 QDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL-------NKKVAQRAAQLQEALL 3306
Query: 2044 LFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLA-RAQADFKCL 2102
F +L +W EE ++ + ++ + Q + L L ++ + +
Sbjct: 3307 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3366
Query: 2103 LELDQQIKALGVPSSPYTWL-TVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQE 2161
++I P+ L + +L+ W+ L + E R ++L+ + Q+
Sbjct: 3367 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISV-------VAQQ 3419
Query: 2162 FEQNASTFLQWILETRAYFLDGSLL-KETGTLESQLEANKRKQKEIQAMKRQLTKIVDLG 2220
F + +W+ ++ + + LE Q+ +K + +I + L + V +G
Sbjct: 3420 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3479
Query: 2221 DNL------EDALILDIKYSTIGLAQQW 2242
+L ED D+ S + +Q W
Sbjct: 3480 QSLKVLSSREDK---DMVQSKLDFSQVW 3504
Score = 122 bits (306), Expect = 4e-27
Identities = 304/1638 (18%), Positives = 627/1638 (38%), Gaps = 208/1638 (12%)
Query: 16 KVLETAEE---IQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIME 71
KVL + E+ +Q + Y +E+ R + L+ + + ++F D +L W+ E
Sbjct: 3483 KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNE 3542
Query: 72 KVNILTDKSYEDPTNIQGKYQKHQSLEA--------EVQTKSRLMSELE---KTREERFT 120
+ L+ S +D + +G +++ L + L++ LE +T +
Sbjct: 3543 VHDKLSKLSVQDYST-EGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL 3601
Query: 121 MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAI 180
+ E KA +++ L + + TLE+ QL R L ++ W+ E
Sbjct: 3602 IIQDKLEAIKARYKDITKLSTDVAK-TLEQALQLARRLHSTH-----EELCTWLDKVEVE 3655
Query: 181 ATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYA-----NECAEENHPDLPL- 234
S E T+VL K E Q ++ KE + N A NE + +P
Sbjct: 3656 LLSYE-------TQVL-KGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWR 3707
Query: 235 ----IQSKQNEVNAAWERLRGLALQRQKALSNAA-NLQRFKRDVTEAIQWIKEKEPVLTS 289
++ E N + + Q+ + + A Q+F + + WI E E L S
Sbjct: 3708 AREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMS 3767
Query: 290 -EDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDL 348
D + + K + D + +L K+ + + Q + K D
Sbjct: 3768 LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK 3827
Query: 349 V-SSWEHIRALATSRYEKLQ-ATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGE 406
V +++ I + + RY +L+ A ++F ++EL W+ E + I+ +LP E
Sbjct: 3828 VLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS--QLPAPALEYE 3885
Query: 407 VLLDRHQQHKHE---IDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLE 463
L + ++H+ I + ++TG L+ + ++EK D ++ + E
Sbjct: 3886 TLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3945
Query: 464 LWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEE 523
+R ++ + + D ++D + E +E S+ + +++ +
Sbjct: 3946 DVKKRAVALDEAISQSTQFHD--KIDQILESLERIVERLRQPPSISAEVEKIKEQISENK 4003
Query: 524 AFTAQEEKII----TVDKTATKLIGDDHYDSENI--KAIRDGLLAR-------RDALREK 570
+ EK+ T+ + ++I ++I KA++D L + E+
Sbjct: 4004 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 4063
Query: 571 AATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQN--LKSRVQKQQVFEK 628
A +LL L +K + D L I + D + I +K + + + +
Sbjct: 4064 EA---KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 4120
Query: 629 ELAVNKTQLENIQKTGQEMIEG-GHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEAN 687
E+ + +L+ + G E+I G V + E+ S W+ L +A K + +L EA
Sbjct: 4121 EIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAM 4180
Query: 688 QQ-LQFENNAEDLQRWLEDVEWQVTS-EDYGKGLAEVQNRLRKHGLLESAVAARQDQVDI 745
Q +Q+++ + + W++ ++ S G L V+ ++ + +S +Q +++
Sbjct: 4181 QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER 4240
Query: 746 LTDLAAYF--EEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLD-LLHLQLICRDT 802
L A + D ++ L +++L+E + R+ KL LL L
Sbjct: 4241 LNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHAL 4300
Query: 803 EDEEAWIQETEPSATSTY-LGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVE 861
++ AW+ TE + +G D A + L +H V+ ++ +H+ ++ + + GN ++E
Sbjct: 4301 DELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIE 4360
Query: 862 -EGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANV-QFQQYLADLHEAETWIREKE 919
A ++ ++++ LNQ +++ + +R+ L+ + Q + + ++ + + W+ + E
Sbjct: 4361 SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTE 4420
Query: 920 -PIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAG 978
++ + G E A L H + ++ K+L + G
Sbjct: 4421 RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQK----------------G 4464
Query: 979 EQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDE 1038
+Q + AR P+ + ++ ++++ + W VE ++ LA +
Sbjct: 4465 QQML-------ARCPKSA---ETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEF 4514
Query: 1039 FPMLPQ-----RRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGD 1093
L + E+ N+ R I + +D + + + + + G
Sbjct: 4515 HNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGT 4574
Query: 1094 MLEWIQEKK----AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGL 1149
L++ +K+ +N + + WE KV L+ G
Sbjct: 4575 HLKYFSQKQDVVLIKNLLISVQSRWE-----------------------KVVQRLVERGR 4611
Query: 1150 LTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAA 1209
+ + ++ + W L +E + L S + A
Sbjct: 4612 SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEI----------------------AN 4649
Query: 1210 DPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKM--EL 1267
DP D Q Q H+ F++ L T L E A ++L+ M EL
Sbjct: 4650 DP--DKIKTQLAQ--HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4705
Query: 1268 NEAWEDLQGRTKDRKESLNEAQKFY-LFLSKARDLQNWISSI-GGMVSSQELAEDLTGIE 1325
+ W+ + G++ +R+ L EA F F + L +W+ + + Q + D+ +
Sbjct: 4706 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4765
Query: 1326 ILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWE 1385
L++ H+ + ++ + QAL+ + ELI+ S VK++ +L WE
Sbjct: 4766 NLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-------SWVKVQMQELSTRWE 4818
Query: 1386 --------KRKKILDQCLELQMFQGNCDQVESWMVARENSLR-----SDDKSSLDSL--- 1429
K+ ++ + + F + W+ E +LR DD+ +L +L
Sbjct: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ 4878
Query: 1430 -----EALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKA 1484
+ L +KR +L+KA T + + +S+ +H+ I R + VL K
Sbjct: 4879 HKEFMKKLEEKRAELNKATTMGDTVLAICH--PDSITTIKHWI-TIIRARFEEVLAWAKQ 4935
Query: 1485 LKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESY----KDATNIQRKYLK 1540
+ +L A L LE L W+ T D+ ++ ++ +
Sbjct: 4936 HQQRLASA------LAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE 4989
Query: 1541 HQTFAHEVDGRSEQVHGV 1558
HQTF E+ + V V
Sbjct: 4990 HQTFMEEMTRKQPDVDKV 5007
Score = 105 bits (262), Expect = 5e-22
Identities = 429/2370 (18%), Positives = 878/2370 (37%), Gaps = 423/2370 (17%)
Query: 187 GEDWERTEVLHKKFEDF----QVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNE- 241
GE + L +FEDF Q V + ++ + N C + L + ++ E
Sbjct: 1003 GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEE 1062
Query: 242 --VNAAWERLRGLALQRQKALSNAANLQRF---KRDVTEAIQWIKEKEPVLTSEDYGKDL 296
N +R + L+ + R + D+ E++ I E+E + + KD
Sbjct: 1063 SVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD- 1121
Query: 297 VASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIR 356
+L +++K +E ++A + S P ++ ++ + +
Sbjct: 1122 ---------------DLGTITNKCEEFFSQA-----AASSSVPTLRSELNVVLQNMNQVY 1161
Query: 357 ALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHK 416
+++++ +KL+ + + + L K A + D E L+ +Q +
Sbjct: 1162 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA--VIADKNNIENLISTLKQWR 1219
Query: 417 HEID-------SYDDRFQSADETGQDLVNANHEAS---DEVREKMEILDNNWTALLELWD 466
E+D + +D Q A ++ E D +EK + L W + D
Sbjct: 1220 SEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1279
Query: 467 ERHRQYEQCLDFHLFYRDS-EQVDSWMSRQEAF---LENEDLGNSLGSAEALLQKHEDFE 522
R R E +YRD+ +D W+ + E ++ NS A L Q
Sbjct: 1280 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQ------ 1333
Query: 523 EAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLL------ARRDALREKAATRRR 576
Q+ + ++ +K+ Y + ++D L A D+ ++ RRR
Sbjct: 1334 -----QKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRR 1388
Query: 577 LLKESLLLQKLYED-------------------SDDLKNWINKKKKLADD-----EDYKD 612
+ + L+ + + D D LK ++K L ++ E K+
Sbjct: 1389 MQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKE 1448
Query: 613 IQNLKSRVQK---------------QQVFEKELAVNKTQLEN--------IQKTGQEMIE 649
+Q S + K Q++ +E++ K QL + K G +M +
Sbjct: 1449 LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTD 1508
Query: 650 GGHYASDNVTTRLSEVASLW-----EELLEATKQKGTQLHE---ANQQLQFENNAEDLQR 701
+ L E +L ++L E+ ++ E A +Q +++ + +
Sbjct: 1509 EERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICD 1568
Query: 702 WLEDVEWQVTSED----YGKGLAEVQNRLRKHGLLESAV-AARQDQVDILTDLAAYFEEI 756
L E ++ G G E++ K L+ + + Q +++ + + +E
Sbjct: 1569 LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1628
Query: 757 GHPDSKDIRARQESLVCRFEALKEPL---ATRKKKLLDLLHLQLICRDTEDEEAWIQETE 813
G S++ +A E + + E L A + KK LD + I +TE A +++ E
Sbjct: 1629 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA-VKQLE 1687
Query: 814 PSATSTYLGKDLIA-----SKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAE 868
S T D ++ S++ +H+ ++E +H + G + G+
Sbjct: 1688 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1747
Query: 869 DVASRV----KSLNQNMESLRARAARRQNDLEANV---QFQQYLADLHEAETWIREKEPI 921
DV +V ++LNQ + ++A+ + + +A + Q Q L + EKE +
Sbjct: 1748 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1807
Query: 922 VDN-----TNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGV 976
N +Y + +K + +L F + +Q+ G
Sbjct: 1808 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 1867
Query: 977 AGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQ--GIVPAVYVRRL 1034
+M Q +V KGD+ + S N+ ++ + G V R
Sbjct: 1868 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHRE 1927
Query: 1035 AHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDM 1094
+ R R ++ + + N + L+D+ Q Y + AG
Sbjct: 1928 VQRKLDHATDRFR----SLYSKCNVLGNNLKDLVDK--------YQHYEDASCGLLAGLQ 1975
Query: 1095 LEWIQEKKAENTGVELDDVWELQKKFDE---FQKDLNTNEPRLRDINKVADDLL-FEGLL 1150
K + + +D LQ++ +E Q +++ + + + K A+ LL G L
Sbjct: 1976 ACEATASKHLSEPIAVDPK-NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSL 2034
Query: 1151 TPEGAQIRQELNS---RWGSLQRLADEQRQ----LLGSAHAVEVFHREADDTKEQIEKKC 1203
P I++ L+ R+ L + +E+ + L + +V+ E D +E
Sbjct: 2035 LPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL 2094
Query: 1204 QALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSES-HPDATEDLQR 1262
+ S ++Q + ++ E+D+ + + E ++ E+ P LQ
Sbjct: 2095 KEQGQVPLNST--ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQA 2152
Query: 1263 QKMELNEAWEDLQGRTKDRKESLNEAQ-KFYLFLSKARDLQNWISSIGGMVSSQELAE-D 1320
+ +L+ + + + K+ + E + K LF + + LQ ++ + +Q L E D
Sbjct: 2153 KMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLET-----KTQALTEVD 2207
Query: 1321 LTGIEI--LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIE-KKLQAVKLER 1377
+ G ++ L + QE ++ + L E+ G + + +K + +
Sbjct: 2208 VPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKF 2267
Query: 1378 DDLEKAWEKRKKILDQCLE-LQMFQGNCDQVESWMV--------------------AREN 1416
++E +++K+ + C E L FQ ++SW+ + E+
Sbjct: 2268 KEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLED 2327
Query: 1417 SLRSDDKSSLDSLEALMKKRDDLD------------KAITAQEGKITDLEHFAESLIADE 1464
+ + +K SL + E + KAI A + L + +E
Sbjct: 2328 TKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEE 2387
Query: 1465 HYA-------KEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWIS 1517
+A K+++ D LK ++ + TKL + L++ + + +W+
Sbjct: 2388 FWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL---SKLQKAQEESSAMMQWLQ 2444
Query: 1518 EMLPTACD----ESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDG 1573
+M TA + D ++ + ++++F E+ +V + + L+E +
Sbjct: 2445 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2504
Query: 1574 NEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQ-QRFNTSIRDFEFWLSEAETLLAM 1632
K+ L ++ W L + T D+ +KL E+S +F T + WL E E ++++
Sbjct: 2505 EAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV 2564
Query: 1633 KDQARDLASAGNLL----KKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688
L+ N+L ++ Q+L +E R+ + L + +LS +
Sbjct: 2565 ---LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS----------RPG 2611
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748
++ + R + ++LAA + L D WI++ +++ S Y L+ +
Sbjct: 2612 EDPSLRGIVKEQLAAVTQK-------WDSLTGQLSDRCDWIDQAIVK--STQYQSLLRSL 2662
Query: 1749 QNLLKK-HKRLEGELV--AHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLK 1805
+ L +L L H A+ L+ A+K+K + + QE+ Q+++AQ + E L
Sbjct: 2663 SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE--IQQEKKQIKVAQAL--CEDLS 2718
Query: 1806 ELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALE 1865
L K LK E S + + +L + +E
Sbjct: 2719 ALVKEEYLKAELSRQ---------------------------------LEGILKSFKDVE 2745
Query: 1866 NDFAVHETRVQNVCAQGEDILNKVLQEESQNKE--ISSKIEALNEKTPSLAKAIAAWKLQ 1923
H +Q+ CA Q+ S++ + + +K E N+ P A
Sbjct: 2746 QKAENHVQHLQSACASSHQ-----FQQMSRDFQAWLDTKKEEQNKSHPISA--------- 2791
Query: 1924 LEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQE 1983
K DV+E+ I D + KT + QS E
Sbjct: 2792 ------------KLDVLESLIKDHKDFSKT---------------------LTAQSHMYE 2818
Query: 1984 RLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAED 2043
+ I + ++ L+ Q ++ A++ + + W+ +++ E++ L+++ +
Sbjct: 2819 K--TIAEGENLLLKTQGSEKAALQLQLNTIKTNWD-------TFNKQVKERENKLKESLE 2869
Query: 2044 LFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLL 2103
+++ + L W +K + NL E C+ + E+ +A L Q
Sbjct: 2870 KALKYKEQVETLWPWIDKCQNNLEEIKFCLD-------PAEGENSIAKLKSLQK------ 2916
Query: 2104 ELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFE 2163
E+DQ VE+L T L + E ++ + E ++ +M E
Sbjct: 2917 EMDQHFG------------MVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE-- 2962
Query: 2164 QNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL 2223
L ++ + L+ T + E +K ++++Q K QL D+ D+L
Sbjct: 2963 ---------QLHSKKFCLENM----TQKFKEFQEVSKESKRQLQCAKEQL----DIHDSL 3005
Query: 2224 EDALILDIKYSTIGLAQQWD---QLYQLGLRMQHNLEQQIQAKDIKGVSEETL------K 2274
+ KY T+ QQ +Q+ L + + ++A D KG S+ L +
Sbjct: 3006 GSQAYSN-KYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQ 3064
Query: 2275 EFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHE-PKFEKFLDAVDPGRKGY 2333
E ST+ + DE + T L+G+ ++ + E + +F+ LD++ P +
Sbjct: 3065 EHSTLSQQVDEKCSFLETK------LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3118
Query: 2334 VSL----EDYTAFLIDKESENIKSSDEIEN 2359
+L E AFL K+ E + +S++ N
Sbjct: 3119 ETLQKQKETIKAFL--KKLEALMASNDNAN 3146
Score = 90.1 bits (222), Expect = 2e-17
Identities = 319/1812 (17%), Positives = 680/1812 (37%), Gaps = 242/1812 (13%)
Query: 697 EDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAV--------AARQDQVDILTD 748
+DL W+++++ Q+ ++G L V++ L H + A+ A+ ++ +
Sbjct: 609 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP 668
Query: 749 LAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAW 808
L + E H R ES + + +++ LD LH + R T +E W
Sbjct: 669 LKLTYAEKLH--------RLESQYAKL----LNTSRNQERHLDTLH-NFVSRAT-NELIW 714
Query: 809 IQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAE 868
+ E E + + + + H ++ + E I+ + E +++ E H A
Sbjct: 715 LNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 774
Query: 869 DVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYG 928
+ + ++ + + ++ N + ++ D EA ++R + + Y
Sbjct: 775 TIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR-KYS 833
Query: 929 ADEEAAGALLK--------------KHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVE 974
D ++ L+ ++++ + +L ++ L+ + + C + + P++
Sbjct: 834 CDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIK 893
Query: 975 GVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKV-EAADHQGIVPAVYVRR 1033
+ +++ E+T+ K D L ++ ++ WKV ++ +VP+V
Sbjct: 894 AICDYRQI------------EITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVC--- 938
Query: 1034 LAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGD 1093
F + P + E ++ R IE QY+++L E + + L E
Sbjct: 939 -----FTVPPPNK--EAVDLANR---IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDR 988
Query: 1094 M-LEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTP 1152
+ + K G + LQ +F++F +D ++ +F G
Sbjct: 989 IRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQ-------------VFSG---S 1032
Query: 1153 EGAQIRQELNSRWGSLQRL-----ADEQRQLLGSAHAVEV--FHREADDTKEQIEKKCQA 1205
+ Q+ +E+N Q L +EQ + + + + EV ++ ++++ ++ +
Sbjct: 1033 DITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 1092
Query: 1206 -LSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQK 1264
L D +F + ++ + ER LG TI + E S++ A+ + +
Sbjct: 1093 PLERDDLHESVFRITEQEKLKKELERLKDDLG---TITNKCEEFFSQA--AASSSVPTLR 1147
Query: 1265 MELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQE-LAEDLTG 1323
ELN +++ +++ + L L + + + + +E + D
Sbjct: 1148 SELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNN 1207
Query: 1324 IEILLERHQEHRADMEAEAPTFQALED---FSAELIDSGHHASPEIEKKLQAVKLERDDL 1380
IE L+ ++ R++++ + F ALED + + D E + K + D L
Sbjct: 1208 IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 1267
Query: 1381 EKAWEKRKKILDQCL--------ELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEAL 1432
+ W+ +D L L+ ++ ++ W+ E + R ++ ++ + L
Sbjct: 1268 VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTL 1327
Query: 1433 ---MKKRDDLDKAITAQEGKITDLEHFAESLIAD-EHYAKEEIATRLQRVLDRWKALKAQ 1488
+ ++ L I ++ K+ + + +AE A + Y + + R + +K +
Sbjct: 1328 ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR 1387
Query: 1489 LIDERTKL--GDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAH 1546
+ L ++ +L+ Y L L + + ++ +++ + +H A
Sbjct: 1388 RMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAK 1447
Query: 1547 E----VDGRSEQVHGVINLGNSLIECSACDGNE-EAMKEQLEQLKEHWDHLLERTNDKGK 1601
E V S+ + G E KEQL + + L + DK
Sbjct: 1448 ELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMT 1507
Query: 1602 KLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLARED 1661
+++ T + SE+ L + D+ ++ + Q +E L
Sbjct: 1508 DEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKL---Q 1564
Query: 1662 ALKDLNTLAED---------LLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEA 1712
+ DL T E+ ++ GT + + K++ + K ++Q A A E +K
Sbjct: 1565 GICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQK---DMQGSAQALAEVVK-- 1619
Query: 1713 YALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNV 1772
+ E++++E ++S +D Q + K ++L + + + V
Sbjct: 1620 -----------NTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKV 1668
Query: 1773 LDMA--EKLKDKAAVGQ-EEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829
+ A E+ + AAV Q EE + ++ ++ + + ++ G K ++ +E
Sbjct: 1669 VTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEG 1728
Query: 1830 EEEAWINEKNAL-------AVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQG 1882
+ ++ I E++ + V G G T K +A +++ + + + + Q
Sbjct: 1729 DGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA-QHEKIISQHQAVIIATQS 1787
Query: 1883 EDIL----NKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKAD 1938
+L + L E + K + E +LA++ KL ++F+
Sbjct: 1788 AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYT 1847
Query: 1939 VVEAWIADKETSLKTNGNGA-DLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLIS 1997
E W+ E L+ GA D+ +T L +Q +SF ++ + DL+ IS
Sbjct: 1848 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQ-------KSFSEDVISHKGDLRYITIS 1900
Query: 1998 AQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNN 2057
+ E + KR ++ SA HR E Q L A D F K + L N
Sbjct: 1901 GNR-----VLEAAKSCSKRDGGKVDTSATHR----EVQRKLDHATDRFRSLYSKCNVLGN 1951
Query: 2058 ------------------------WCE-KMEENLSEPVHCVSLNEIRQLQ--KDHEDFLA 2090
CE ++LSEP+ N RQL+ K + ++
Sbjct: 1952 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQIS 2011
Query: 2091 SLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEA 2150
S A K E+ + +P+ T++ + ++ LS + ER ++LQ
Sbjct: 2012 SQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLT 2071
Query: 2151 RQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEAN-KRKQKEIQAM 2209
R + + E + E L+ + L++ + LE + +Q I AM
Sbjct: 2072 RSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAM 2131
Query: 2210 KRQLTKIVDLGDNLEDALI------LDIKYSTIG------------LAQQWDQLYQLGLR 2251
++ K ++ D + + L ++S L + + L +
Sbjct: 2132 NEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEK 2191
Query: 2252 MQHNLEQQIQA---KDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLP 2308
+Q LE + QA D+ G K+ + + ++ E+ + L HK+ L L
Sbjct: 2192 LQTFLETKTQALTEVDVPG------KDVTELSQYMQESTSEFLEHKKHLEVLHSL----- 2240
Query: 2309 MVEEDEHEPKFEK--FLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALAE 2366
+ E H +K L+ + K + +ED I ++ E + S E +AFQ L +
Sbjct: 2241 LKEISSHGLPSDKALVLEKTNNLSKKFKEMED----TIKEKKEAVTSCQEQLDAFQVLVK 2296
Query: 2367 GKSYITKEDMKQ 2378
KE K+
Sbjct: 2297 SLKSWIKETTKK 2308
Score = 69.7 bits (169), Expect = 3e-11
Identities = 423/2395 (17%), Positives = 896/2395 (37%), Gaps = 430/2395 (17%)
Query: 68 WIMEKVN--ILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSA 125
W+ EK + D S E TNI K H L E+ K + +++ E+ H A
Sbjct: 714 WLNEKEEEEVAYDWS-ERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPA 772
Query: 126 HEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGD-KEA----- 179
+A+ ++ W +L+L +Q+++E E+ D KEA
Sbjct: 773 RLTIEAYRAAMQTQWSWILQL----------CQCVEQHIKENTAYFEFFNDAKEATDYLR 822
Query: 180 -IATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSK 238
+ +++ +R+ +HK + Q + KE E+ QY + A +IQ K
Sbjct: 823 NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKE----ELLQYKSTIANLMGKAKTIIQLK 878
Query: 239 QNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVA 298
+ + + KA+ + ++ I K+ E VL +
Sbjct: 879 PRNSDCPLKTSIPI-----KAICDYRQIE---------ITIYKDDECVLAN--------- 915
Query: 299 SEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRAL 358
+SH+ + ++ ++ A + + P + ++ + ++++ L
Sbjct: 916 -----NSHRAKWKVISPTGNE-----AMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL 965
Query: 359 ATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHE 418
+ +++ +H ++ D + A N + T + G +H+
Sbjct: 966 WHESHINMKSVVSWHYLINEIDRI--------RASNVASIKTMLPG---------EHQQV 1008
Query: 419 IDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDF 478
+ + RF+ E Q+ + ++ +++ + + LL+ ER Q E +
Sbjct: 1009 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKS-AEREEQEESVYNL 1067
Query: 479 HLF------YRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKI 532
++ R D + + LE +DL S+ + + E ++ ++ +
Sbjct: 1068 YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESV----FRITEQEKLKKELERLKDDL 1123
Query: 533 ITVDKTATKLIGDDHYDSE--NIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYED 590
T+ + S +++ + +L + + ++T LK L+ K +
Sbjct: 1124 GTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA 1183
Query: 591 SDDLKNWINKKKKLADDE----DYKDIQNLKSRV--------QKQQVF---EKELAVNKT 635
++ L + KL ++E D +I+NL S + +K+QVF E EL K
Sbjct: 1184 AEALVKLY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKA 1241
Query: 636 QLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FEN 694
+ + KT +E D + ++ W+ + + L + L+ + +
Sbjct: 1242 ISDEMFKTYKER----DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRD 1297
Query: 695 NAEDLQRWLEDVE--WQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAY 752
L W++ VE + E+ + + +L + +L S + +Q ++D A
Sbjct: 1298 TYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ 1357
Query: 753 FEEI----------------GHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQ 796
+ S R R +S L TR L+ L+
Sbjct: 1358 YSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQY 1417
Query: 797 LICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERG 856
+ + D ++E E S K+ + + + + + +++ +++ + G
Sbjct: 1418 I--KFAGDSLKRLEEEEKSLEE--------EKKEHVEKAKELQKWVSNISKTLKDAEKAG 1467
Query: 857 NKMVEEGHFAAEDVASRVKSLNQNMESLRARAAR--------RQNDLEA---------NV 899
+ ++E+++++ + L++ +++++ A+ +N+LE N+
Sbjct: 1468 KPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNL 1527
Query: 900 QFQQYLADLHEAETW--IREKEPIVDNTNYGADEEAAG----------ALLKKHEAFLLD 947
F + L L E++T ++ +E IV E+ G L+ EAF++
Sbjct: 1528 LFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI- 1586
Query: 948 LNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLL 1007
GD L+ Q +Q + + G + +A EV + L
Sbjct: 1587 ----GDGTVELKKY----QSKQEELQKDMQGSAQALA----------EVVKNTENFL--- 1625
Query: 1008 SSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSL 1067
++ K+ D I + ++ ++ + ++ ++E + + E + +
Sbjct: 1626 ---KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA 1682
Query: 1068 LDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQ--EKKAENTGVELDDVWELQKKFDEFQK 1125
+ + EE + ++ ++L+W+ +K +E G + V +++ FQ+
Sbjct: 1683 VKQLEESKTKI-------------ENLLDWLSNVDKDSERAGTKHKQV--IEQNGTHFQE 1727
Query: 1126 DLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAV 1185
+ + + ++V +LL E + + ++ LN ++ Q++ + +++ AV
Sbjct: 1728 --GDGKSAIGEEDEVNGNLL-ETDVDGQVGTTQENLNQQY---QKVKAQHEKIISQHQAV 1781
Query: 1186 EVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGET 1245
+ + A + +EK+ Q LS + +++ L+ +E L K+ +
Sbjct: 1782 IIATQSA---QVLLEKQGQYLSPEEKEKLQKNMKELKVH---YETALAESEKKMKLTHSL 1835
Query: 1246 AERLSESHPDATED---LQRQKMELNE---AWEDLQG------RTKDRKESL--NEAQKF 1291
E L + D TE LQ+ + EL +D+ G R K E + ++
Sbjct: 1836 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1895
Query: 1292 YLFLSKARDLQ---NWISSIGGMVSSQELAEDLTGIEILLERHQEHRAD-MEAEAPTFQA 1347
Y+ +S R L+ + GG V D + ++R +H D +
Sbjct: 1896 YITISGNRVLEAAKSCSKRDGGKV-------DTSATHREVQRKLDHATDRFRSLYSKCNV 1948
Query: 1348 LEDFSAELIDSGHH---ASPEIEKKLQAVK--LERDDLEKAWEKRKKILDQCLELQMFQG 1402
L + +L+D H AS + LQA + + E K + Q E + QG
Sbjct: 1949 LGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQG 2008
Query: 1403 NCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIA 1462
Q+ S VA E L+ + LD+ +L+ ++D+ K + G+ DL S
Sbjct: 2009 ---QISSQQVAVE-KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDL-----SKSV 2059
Query: 1463 DEHYAKEEIA-TRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLP 1521
+E K +I TR V D L+E+ +W+ +
Sbjct: 2060 NERNEKLQITLTRSLSVQD---------------------------GLDEMLDWMGNVES 2092
Query: 1522 TACDESY--KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMK 1579
+ ++ ++T +Q K+ ++ GR ++ AM
Sbjct: 2093 SLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSIN--------------------AMN 2132
Query: 1580 EQLEQLKEHWD-----HLLERTNDKGKKLNEAS--------RQQRFNTSIRDFEFWLSEA 1626
E++++ E D L + D + +EAS + + T + FE +
Sbjct: 2133 EKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKL 2192
Query: 1627 ETLLAMKDQA--------RDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGT 1678
+T L K QA +D+ +++ E L + L+ L++L +++ S G
Sbjct: 2193 QTFLETKTQALTEVDVPGKDVTELSQYMQES---TSEFLEHKKHLEVLHSLLKEISSHGL 2249
Query: 1679 FNVDQIV-KKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDL-DDEESWIEEKLIRV 1736
+ +V +K +N++K+F +++ E + FQ L +SWI+E +V
Sbjct: 2250 PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV 2309
Query: 1737 SSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL-----------KDKAAV 1785
+ + L+ K+L+ + P IQ V + L K AAV
Sbjct: 2310 PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAV 2369
Query: 1786 -----------------------GQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYL 1822
G I+ + +E L L K + +L L L
Sbjct: 2370 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL 2429
Query: 1823 QFMQNAEEEEA----WINEKNALAVRGDCGDTLAATQSLLMKHEALEN-DFAVHETRVQN 1877
Q A+EE + W+ + N A + T A T + +K + +N F + N
Sbjct: 2430 ---QKAQEESSAMMQWLQKMNKTATKWQ--QTPAPTDTEAVKTQVEQNKSFEAELKQNVN 2484
Query: 1878 VCAQGEDILNKVLQEESQN----------KEISSKIEALNEKTPSLAKAIAAWKLQLEDD 1927
+ +D L ++L+E EI SK + LN+ T + + E
Sbjct: 2485 KVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE------ESS 2538
Query: 1928 YAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSF--QQERL 1985
+F ++ W+ +KE + G + + L +Q + LQ F ++ +
Sbjct: 2539 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQ--VQILLQEFATRKPQY 2596
Query: 1986 PEITDLKDKLISAQHNQSK---AIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE 2042
++T ++S ++E+ AA+ ++W+ L + + + + + +
Sbjct: 2597 EQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQ 2656
Query: 2043 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLN-EIRQLQKDHEDFLASLARAQADFKC 2101
L + K S L+N K+ +L+ H ++N ++ QK ++ + + + K
Sbjct: 2657 SLLRSLSDKLSDLDN---KLSSSLAVSTHPDAMNQQLETAQKMKQE----IQQEKKQIKV 2709
Query: 2102 LLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQE 2161
L + + AL L+ + LE K D+ ++ E +Q ++ + +
Sbjct: 2710 AQALCEDLSALVKEEYLKAELSRQ-LEGILKSFKDVEQKAENHVQHLQSACASS----HQ 2764
Query: 2162 FEQNASTFLQWILETRAYFLDGS--LLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDL 2219
F+Q + F W L+T+ + S + + LES ++ +K K + A K +
Sbjct: 2765 FQQMSRDFQAW-LDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE 2823
Query: 2220 GDNL------EDALILDIKYSTIGLAQQWD----QLYQLGLRMQHNLEQQIQAKD 2264
G+NL + L ++ +TI WD Q+ + +++ +LE+ ++ K+
Sbjct: 2824 GENLLLKTQGSEKAALQLQLNTI--KTNWDTFNKQVKERENKLKESLEKALKYKE 2876
Score = 41.2 bits (95), Expect = 0.012
Identities = 42/210 (20%), Positives = 92/210 (43%), Gaps = 23/210 (10%)
Query: 574 RRRLLKESLLLQKLYEDS------DDLKNWINKKKKLADDEDY-KDIQNLKSRVQKQQ-- 624
R+ LLK SLL Q L E+ DL NW+++ + D ++ D+ +++S ++ +
Sbjct: 585 RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNV 644
Query: 625 ---VFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGT 681
+ E E ++ + ++ IQ T + YA +L + S + +LL ++ +
Sbjct: 645 HRAIEEFESSLKEAKISEIQMTAPLKLT---YAE-----KLHRLESQYAKLLNTSRNQER 696
Query: 682 QLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQD 741
L + F + A + WL + E + + D+ + + + H L + +++
Sbjct: 697 HLDTLH---NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 753
Query: 742 QVDILTDLAAYFEEIGHPDSKDIRARQESL 771
+ + ++A HP I A + ++
Sbjct: 754 NIKSVQEIAEQLLLENHPARLTIEAYRAAM 783
Score = 40.8 bits (94), Expect = 0.016
Identities = 60/342 (17%), Positives = 134/342 (39%), Gaps = 53/342 (15%)
Query: 1707 EKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHE 1766
+ L E +F QDL +W++E +++ ++G DL V++ L+ HK + + E
Sbjct: 596 QNLTEEEINMKFVQDL---LNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFE 652
Query: 1767 PAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKL------EESLE 1820
+++ K+ EIQ+ + + EKL L L E L+
Sbjct: 653 SSLKEA-----KI--------SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLD 699
Query: 1821 YL-QFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVC 1879
L F+ A E W+NEK + E + D++ T +
Sbjct: 700 TLHNFVSRATNELIWLNEK---------------------EEEEVAYDWSERNTNIARKK 738
Query: 1880 AQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADV 1939
+++ ++ Q+E K + E L + I A++ ++ +++
Sbjct: 739 DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSW--ILQLCQC 796
Query: 1940 VEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQ 1999
VE I + + + + D+L ++ DA + + +R I L+D + +
Sbjct: 797 VEQHIKENTAYFEFFNDAKEATDYL-----RNLKDAIQRKYSCDRSSSIHKLEDLVQESM 851
Query: 2000 HNQSKAIEER--YAALLKRWEQLLEASAVHRQKLLEKQLPLQ 2039
+ + ++ + A L+ + + +++ + L+ +P++
Sbjct: 852 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIK 893
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 214 bits (546), Expect = 6e-55
Identities = 443/2242 (19%), Positives = 900/2242 (40%), Gaps = 244/2242 (10%)
Query: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQV-FKRDADDLGKWIMEKVNILTD-KSY 81
+Q + + T + +F ++V ER KL++S + +K + L WI + N L + K
Sbjct: 2513 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2572
Query: 82 EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHE----ETKAHIE--- 134
DP + K +SL+ E+ ++ L T ++ E E K+ I+
Sbjct: 2573 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2632
Query: 135 ---ELRHLWDLLLELTLEKGDQLLRALKFQQYVQECA----DILEWIGDK---------- 177
E H LE +K + K + +CA DI + +G +
Sbjct: 2633 MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML 2692
Query: 178 -------EAIATSVELGEDWERTEVLH----KKFED--FQVELVAKEGRVVEVNQYANEC 224
+A+ V+L + + V+ K D QVE +A+E + +Q +E
Sbjct: 2693 QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL--SQQVDEK 2750
Query: 225 AEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKE 284
L I QN + + + + + + ++ ++K+ E
Sbjct: 2751 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLE 2810
Query: 285 PVLTSEDYG----KDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQ 340
++ S D K ++A+E G++R+L +S + +L +A+
Sbjct: 2811 ALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR---------- 2860
Query: 341 IQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPT 400
+E E + E Y KL+ + + + +E G + +T IN
Sbjct: 2861 -EEQVEGTIKRLEEF-------YSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMF 2912
Query: 401 DVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN--ANHEASDEVREKMEILDNNW 458
V K EI+ + Q + GQ L+ A ++ + ++ ++ W
Sbjct: 2913 KVF-----------QKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 2961
Query: 459 TALLELWDERHRQYEQCLDFHLFYRDS-EQVDSWMSRQEAFLENEDLGNS-LGSAEALLQ 516
L + +R Q ++ L ++D+ E + SWM E + N+ ++ +A +Q
Sbjct: 2962 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3021
Query: 517 KHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLL--ARRDALREKAATR 574
+ + + ++ + + + K I ++ +K ++ L +R +AL KA TR
Sbjct: 3022 EQKLLQRLLDDRKSTVEVIKREGEK-IATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3080
Query: 575 RRLLKE-SLLLQKLYEDSDDLKNWINK-KKKLADDEDY-KDIQNLKSRVQKQQVFEKELA 631
R L+ S++ Q+ +E + L W+ +K+L + E L+ ++ + + E ++
Sbjct: 3081 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3140
Query: 632 VNKTQLENIQKTGQEM-IEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEA--NQ 688
+ L GQ + + D V ++L + E+ E + + L +A N
Sbjct: 3141 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3200
Query: 689 QLQFENNAEDLQRWLEDVEWQVTS---EDYG-KGLAEVQNRLRKHGLLESAVAARQDQVD 744
++ E+ E L WL +V +++ +DY +GL + Q+ LR +L+ + R+ VD
Sbjct: 3201 KIFGEDEVE-LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR---VLQEDILLRKQNVD 3256
Query: 745 --ILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT 802
+L L + G + I+ + E++ R++ + + K L L L T
Sbjct: 3257 QALLNGLELLKQTTGD-EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHST 3315
Query: 803 EDEEA-WIQETEPSATS--TYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKM 859
+E W+ + E S T + K AS+ + R + + + +++ + + E + +
Sbjct: 3316 HEELCTWLDKVEVELLSYETQVLKGEEASQAQM-RPKELKKEAKNNKALLDSLNEVSSAL 3374
Query: 860 VEEGHFAA-EDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAE-TWIRE 917
+E + A E + V N+ + ++ +++A + Q +AE +WI E
Sbjct: 3375 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITE 3434
Query: 918 KEP-IVDNTNYGADEEAAGALLKKHEAFLLDL----NSFGDSMKALRNQANACQQQQAAP 972
E ++ + +++ A L+ + F +++ + D +K+ AC +++
Sbjct: 3435 TEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQS 3494
Query: 973 VEGVAGEQRVMALYDF--QARSPREVTMKKGDVLTLLSSINKDWWKVEA-----ADHQGI 1025
++ +V+ YD Q S R + +++ L +N+ W E + Q I
Sbjct: 3495 MKKKL--DKVLKNYDTICQINSERYLQLERAQSL-----VNQFWETYEELWPWLTETQSI 3547
Query: 1026 VPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRS---LLDRAEERRRRLLQRY 1082
+ + L ++ + R+ I + + I+ ++ LL+ + + ++Y
Sbjct: 3548 ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKY 3607
Query: 1083 NEFLLAYEAGDMLEWIQEKKAENTGVELDDV----WELQKKFDEFQKDLNTNEPRLRDIN 1138
A D L ++ + V LD+ + K D+ + L RLR
Sbjct: 3608 -------VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPP 3660
Query: 1139 KVADDL--LFEGLLTPEGAQIRQE-LNSRWGSLQRLADEQRQLLG------SAHAVE--- 1186
++ ++ + E + + + E L + +L++ +E G SA AV+
Sbjct: 3661 SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKL 3720
Query: 1187 -------------VFHREAD--DTKEQIEKK-CQALSAA--------------DPGSDLF 1216
V REA D E EK C +S DPG D
Sbjct: 3721 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 3780
Query: 1217 SVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKM-ELNEAWEDLQ 1275
V+ Q E ++ L +++ I+ L + + + + ++ + ELN AW+ L
Sbjct: 3781 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLN 3840
Query: 1276 GRTKDRKESLNEA-QKFYLFLSKARDLQNWISSIGGMVSSQE-LAEDLTGIEILLERHQE 1333
KDR + L EA Q + + + +W+ GG ++S + DL ++ +E ++
Sbjct: 3841 KAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQ 3900
Query: 1334 HRADMEAEAPTFQALEDFSAELI------DSGHHASPEIEKKLQAVKLERDDLEKAWEKR 1387
+++ + + L + AEL+ +S H ++ L +KL D LE+ R
Sbjct: 3901 FKSEAYQQQIEMERL-NHQAELLLKKVTEESDKHT---VQDPLMELKLIWDSLEERIINR 3956
Query: 1388 K-KILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLD--SLEALMKKRDDLDKAIT 1444
+ K+ L L FQ D++ +W+ E L D ++E + K L +
Sbjct: 3957 QHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVL 4016
Query: 1445 AQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLD----RWKALKAQLIDERTKL-GDY 1499
A + + + LI E A EE A+ LQ L+ RW+ + + + +L G
Sbjct: 4017 AHQSTVEAVNKAGNDLI--ESSAGEE-ASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4073
Query: 1500 ANLKQFYRDLEELEEWISE----MLPT----ACDESYKDATNIQRKYLKHQTFAHEVDGR 1551
K F+ ++E+L++W+++ +L + E+ K+ N+ H + +
Sbjct: 4074 RQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV------HMEVCAAFEAK 4127
Query: 1552 SEQVHGVINLGNSLIECSACDGNEEAMKEQ-LEQLKEHWDHLLERTNDKGKKLNEA-SRQ 1609
E ++ G ++ + C + E +Q + LKE W+ + + N++ KL EA +
Sbjct: 4128 EETYKSLMQKGQQML--ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLA 4185
Query: 1610 QRFNTSIRDFEFWLSEAE-TLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNT 1668
F+ S++DF WL++AE TL + L + + +H++ E+ + + + +L+
Sbjct: 4186 MEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDK 4245
Query: 1669 LAEDL-LSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF-QFFQDLDDEE 1726
L S +V I +V R+ V + L +A QF +
Sbjct: 4246 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4305
Query: 1727 SWIEEKLIRVSSQ-DYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAV 1785
W+EE + S+ + D ++ L +HK + L A LK+K ++
Sbjct: 4306 EWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4365
Query: 1786 GQEEIQL--RLAQFVEHWEKLKELAKARGLKLEESLEYL-QFMQNAEEEEAWINE-KNAL 1841
+ ++L L++ + W+ + + R KLEE+L + QF + W+ + L
Sbjct: 4366 ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4425
Query: 1842 AVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEES----QNK 1897
A + +L+ H+A + + + VQ + +++ + S Q +
Sbjct: 4426 AEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQ 4485
Query: 1898 EISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNG 1957
E+S++ E + + S + A Q E EF+ + W+A+ E +L+ +G
Sbjct: 4486 ELSTRWETVCALSISKQTRLEAALRQAE------EFHSVVHALLEWLAEAEQTLRFHGVL 4539
Query: 1958 ADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLK-R 2016
D D L L Q ++ L + T + D +++ H S + + +++ R
Sbjct: 4540 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4599
Query: 2017 WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLN 2076
+E++L + H+Q+L L ++L A W E + + V +
Sbjct: 4600 FEEVLAWAKQHQQRLASALAGLIAKQELLEALL----AWLQWAETTLTDKDKEVIPQEIE 4655
Query: 2077 EIRQLQKDHEDFLASLARAQAD 2098
E++ L +H+ F+ + R Q D
Sbjct: 4656 EVKALIAEHQTFMEEMTRKQPD 4677
Score = 194 bits (493), Expect = 9e-49
Identities = 436/2211 (19%), Positives = 894/2211 (40%), Gaps = 271/2211 (12%)
Query: 56 QVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTR 115
++ K D K +++KV+++T++ + ++ QK + + + R + ++
Sbjct: 2614 EIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQL 2673
Query: 116 EERFTMGHSAH--------EETKAHIEELRH--------LWDLLLELTLEKGDQLLRALK 159
+ ++G A+ + + ++ L+H DL++E + KG + L+
Sbjct: 2674 DIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDV-LLQ 2732
Query: 160 FQQYVQECADILEWIGDK-EAIATSVE-LGEDWERTEVLHKKFEDFQVEL--VAKEGRVV 215
+ QE + + + + +K + T ++ +G + +F +F EL +A GR
Sbjct: 2733 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 2792
Query: 216 EVNQYANE---------------------------CAEENHPDLPLIQSKQNEVNAAWER 248
E Q E EE PDL I+ ++ +
Sbjct: 2793 ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK 2852
Query: 249 LRGLALQRQKALSNA--------ANLQRFKRDVTEAIQWIKEKEPV-LTSEDYGKDL--- 296
L A R++ + + L+ F + +A + + + PV + +E + L
Sbjct: 2853 LLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMF 2912
Query: 297 -VASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLT-LSHPSDAPQIQEMKEDLVSSWEH 354
V + +G ++++ + + + AK+ L H D D+ + W+
Sbjct: 2913 KVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD---------DVNARWKT 2963
Query: 355 IRALATSRYEKLQATYWY-HRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQ 413
+ R +LQ + RF + L WM + T + A++ P A +V+ + Q
Sbjct: 2964 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD-TEELVANQKPPS-AEFKVVKAQIQ 3021
Query: 414 QHKHEIDSYDDRFQSADETGQD--LVNANHEASDEVR--EKMEILDNNWTALLELWDERH 469
+ K DDR + + ++ + E +D+V+ +++ +LD+ W ALL + R+
Sbjct: 3022 EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN 3081
Query: 470 RQYEQC-LDFHLFYRDSEQVDSWMSRQEAFLEN-EDLGNSLGSAEALLQKHEDFEEAFTA 527
RQ E + F+ E ++ W++ E L N E +G E + +H+ E+
Sbjct: 3082 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3141
Query: 528 QEEKIITVDKTATKL-IGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQK 586
+ + L + D + +++ D ++EK+ +R LL+++L K
Sbjct: 3142 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3201
Query: 587 LY-EDSDDLKNWINK---KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQK 642
++ ED +L NW+N+ K +DY + L + + +V ++++ + K ++
Sbjct: 3202 IFGEDEVELMNWLNEVHDKLSKLSVQDYST-EGLWKQQSELRVLQEDILLRKQNVDQALL 3260
Query: 643 TGQEMIEGGHYASDNVTT---RLSEVASLWEELLEATKQKGTQLHEANQQLQ-FENNAED 698
G E+++ D V +L + + ++++ + + L +A Q + + E+
Sbjct: 3261 NGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEE 3318
Query: 699 LQRWLEDVEWQVTSEDYG--KGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEI 756
L WL+ VE ++ S + KG Q ++R L + A + +D L ++++ E+
Sbjct: 3319 LCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA-KNNKALLDSLNEVSSALLEL 3377
Query: 757 GHPDSKDIRARQ--ESLVC----RFEALKEPLATRKKKLLD--LLHLQLICRDTEDEEAW 808
RAR+ E +V R+ + + + T+K + +D +L Q + + E +W
Sbjct: 3378 -----VPWRAREGLEKMVAEDNERYRLVSDTI-TQKVEEIDAAILRSQQFDQAADAELSW 3431
Query: 809 IQETEPSATST---YLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHF 865
I ETE S L +D +++ L + I H+ I ++ + G+K++
Sbjct: 3432 ITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDIIDDLVKSGHKIMTA--C 3487
Query: 866 AAEDVASRVKSLNQ---NMESLRARAARRQNDLE-ANVQFQQYLADLHEAETWIREKEPI 921
+ E+ S K L++ N +++ + R LE A Q+ E W+ E + I
Sbjct: 3488 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI 3547
Query: 922 VDNTNYGA-----------DEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQA 970
+ A + L+ +H+ + +N G + L
Sbjct: 3548 ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL------------ 3595
Query: 971 APVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAA--DHQGIVPA 1028
+P EG + +++ +A ++ +V + + +S + K++ + IV
Sbjct: 3596 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3655
Query: 1029 VYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRL--LQRYNEFL 1086
+ E + ++ E N++ E+++ Y +L R EE R +
Sbjct: 3656 LRQPPSISAEVEKIKEQISENK-NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 3714
Query: 1087 LAYEAGDMLEWIQEK---KAENTGVELDDVWELQKKF--------------DEFQKDLN- 1128
+ D + +I E E +L DV EL +KF +F +DL
Sbjct: 3715 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED 3774
Query: 1129 -------------TNEPRLRDINKVADDL---------LFEGLLTPEGAQIRQ---ELNS 1163
E +I+ + ++L L P+ +++ ELNS
Sbjct: 3775 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 3834
Query: 1164 RWGSLQRLADEQRQLLGSAHAVEVFHREA-DDTKEQIEKKCQALSAADP-GSDLFSVQAL 1221
W SL + ++ L A V +++ + ++ L++ P G+DL +V+
Sbjct: 3835 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 3894
Query: 1222 QRRHEGFERDLVPLGDKVTILGETAERLSESHPDATED--LQRQKMELNEAWEDLQGRTK 1279
+ F+ + ++ L AE L + + ++ +Q MEL W+ L+ R
Sbjct: 3895 IEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERII 3954
Query: 1280 DRKESLNEAQKFYLFLSKARD-LQNWISSIGGMVSSQE-LAEDLTGIEILLERHQEHRAD 1337
+R+ L A A D L W++ G++S Q+ + D IEI L +H + D
Sbjct: 3955 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQND 4014
Query: 1338 MEAEAPTFQALEDFSAELIDS--GHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCL 1395
+ A T +A+ +LI+S G AS ++ KL+ + ++ + E+RK+ LD L
Sbjct: 4015 VLAHQSTVEAVNKAGNDLIESSAGEEAS-NLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4073
Query: 1396 -ELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDK----AITAQEGKI 1450
+ + F G + ++ W+ E L + L L K++ ++ A A+E
Sbjct: 4074 RQAKGFHGEIEDLQQWLTDTERHLLAS--KPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4131
Query: 1451 TDLEHFAESLIAD-EHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLK-QFYRD 1508
L + ++A A+ I + + ++W++++ +L + +TKL + NL +F+
Sbjct: 4132 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4191
Query: 1509 LEELEEWISEMLPTACDESYKDAT--NIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLI 1566
L++ W+++ T S + + +H+ FA+EV+ EQ+ + G L
Sbjct: 4192 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4251
Query: 1567 ECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEA-SRQQRFNTSIRDFEFWLSE 1625
S + +K L ++ W+ +++R ++G+ L++A R ++F+ + WL E
Sbjct: 4252 YFSQKQ-DVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEE 4310
Query: 1626 AETLLAMK-DQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQI 1684
+E L + + A D L +H+ ++ + A+ N L T D
Sbjct: 4311 SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEK-TSLADDN 4369
Query: 1685 VKKKDNVNK---RFLNVQELAAAHHEKLKEAYALF-QFFQDLDDEESW---IEEKLIRVS 1737
+K D +++ ++ + + KL+EA QF L W +E +L
Sbjct: 4370 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL--AE 4427
Query: 1738 SQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQF 1797
Q D+ V NL+ HK + EL ++Q + A +L + + +++++ +
Sbjct: 4428 DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQEL 4487
Query: 1798 VEHWEKLKELAKARGLKLEESLEYL-QFMQNAEEEEAWINE-KNALAVRGDCGDTLAATQ 1855
WE + L+ ++ +LE +L +F W+ E + L G D A +
Sbjct: 4488 STRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALR 4547
Query: 1856 SLLMKHEALENDFAVHETRVQNVCAQGEDIL----------------------NKVLQEE 1893
+L+ +H+ + G+ +L +VL
Sbjct: 4548 TLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWA 4607
Query: 1894 SQNKE-ISSKIEALNEKTPSLAKAIAAWKLQLE---DDYAFQEFNWKADVVEAWIADKET 1949
Q+++ ++S + L K L +A+ AW E D + + + V+A IA+ +T
Sbjct: 4608 KQHQQRLASALAGLIAK-QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQT 4666
Query: 1950 SLKTNGNGADLGDFLTLLAKQDTLD-ASLQSF---------QQERLPEITDLKDKLISAQ 1999
++ D +T K+ D +SLQS ++R P S
Sbjct: 4667 FMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFP----ASSLYPSGS 4722
Query: 2000 HNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAH 2050
Q + R L+ +W+Q+ + R+KL + L + E+L EFA+
Sbjct: 4723 QTQIETKNPRVNLLVSKWQQVWLLALERRRKLND---ALDRLEEL-REFAN 4769
Score = 156 bits (395), Expect = 2e-37
Identities = 445/2411 (18%), Positives = 946/2411 (39%), Gaps = 288/2411 (11%)
Query: 39 KERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTN-----IQGKYQK 93
K+++AE KL LQ + ++ + +W+ +K+N K + P ++ + ++
Sbjct: 2090 KDKIAELNTKLSK---LQKAQEESSAMMQWL-QKMNKTATKWQQTPAPTDTEAVKTQVEQ 2145
Query: 94 HQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEET--KAHIEELRHLWDLLLELTLEKG 151
++S EAE++ + EL+ E E K + E+ W L +LT+++
Sbjct: 2146 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2205
Query: 152 DQLLRALK-FQQYVQECADILEWIGDKEAIATSV-ELGEDWERTEVLHKKFEDFQVELVA 209
+L + Q+ A + +W+ +KE + + + L D ++ + E
Sbjct: 2206 QKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFAT 2265
Query: 210 KEGRVVEVNQYANECAEENHPDLPL---IQSKQNEVNAAWERLRGLALQR----QKALSN 262
++ + ++ D L ++ + V W+ L G R +A+
Sbjct: 2266 RKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK 2325
Query: 263 AANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKE 322
+ Q R +++ + + K + D + + + + +++ + ++K
Sbjct: 2326 STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQ--LETAQKMKQEIQQEKKQIKV 2383
Query: 323 LCAKAEKLTLSHPSD--APQIQEMKEDLVSSWEHIRALATSRYEKLQ-ATYWYHRFSSDF 379
A E L+ + ++ E ++ S++ + A + + LQ A H+F
Sbjct: 2384 AQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2443
Query: 380 DELSGWMNEKTAAINADE-LPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN 438
+ W++ K N + + E L+ H+ + + ++ G++L+
Sbjct: 2444 RDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL- 2502
Query: 439 ANHEASDEVREKMEI--LDNNWTALLELWDERHRQYEQCLDFHLFYRDS-EQVDSWMSRQ 495
+ S++ ++++ + NW + ER + ++ L+ L Y++ E + W+ +
Sbjct: 2503 LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2562
Query: 496 EAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555
+ LE E + K + ++ + ++ TA L+ D E +
Sbjct: 2563 QNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2622
Query: 556 IRDGLLARRDALREKAATRRRLLKESLLLQKLYED-SDDLKNWINKKKKLADDEDYKDIQ 614
L+ + D + E+ +++ L+ K +++ S + K + K+ D D Q
Sbjct: 2623 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQ 2682
Query: 615 NLKSR-VQKQQVFEKELAVNKTQLENIQKTGQEMI--EGGHYASDNVTTRLSEVASLWEE 671
++ + Q +K L K Q++ ++ Q+++ + +V ++ +A
Sbjct: 2683 AYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHST 2742
Query: 672 LLEATKQKGTQLHEANQQL-QFENNAEDLQRWLEDVEWQVTS--------EDYGKGLAEV 722
L + +K + L Q + F+N ++ + + ++ S E K +
Sbjct: 2743 LSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETI 2802
Query: 723 QNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPL 782
+ L+K LE A+ A D + + EE PD I+ E+L + L +
Sbjct: 2803 KAFLKK---LE-ALMASNDNANKTCKMMLATEETS-PDLVGIKRDLEALSKQCNKLLDRA 2857
Query: 783 ATRKKKLLDLL-HLQLICRDTEDEEAWIQETEPSATSTY-LGKDLIASKKLLNRHRVIL- 839
R++++ + L+ ++ +Q+ E S +G + + LN +V
Sbjct: 2858 QAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQK 2917
Query: 840 ENIASHEPRIQEITERGNKMVEEGHFAA---------EDVASRVKSLNQNMESLRAR--- 887
E I + + Q++ G +++ + +DV +R K+LN+ + A+
Sbjct: 2918 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 2977
Query: 888 ----AARRQNDLEA------------------NVQFQQYLADLHEAETWIR---EKEPIV 922
R Q+ LE+ + +F+ A + E + R +++ V
Sbjct: 2978 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV 3037
Query: 923 DNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRV 982
+ ++ A A L L+ +AL N+A +Q +EG++ V
Sbjct: 3038 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQ----LEGIS----V 3089
Query: 983 MALYDFQARSPRE---VTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEF 1039
+A + P T++K V + + A H+ + + +
Sbjct: 3090 VAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQA 3149
Query: 1040 PMLPQR-----RREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRY-NEFLLAYEAGD 1093
+ Q RE+ + + + + Y + +++ R L Q N + + +
Sbjct: 3150 VSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVE 3209
Query: 1094 MLEWIQEKKAENTGVELDD-----VWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEG 1148
++ W+ E + + + + D +W+ Q + Q+D+ LR N D L G
Sbjct: 3210 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI-----LLRKQN--VDQALLNG 3262
Query: 1149 L-----LTPEGAQIRQE----LNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQI 1199
L T + I Q+ + +R+ + +L+ + + L A + R T E++
Sbjct: 3263 LELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA---RRLHSTHEEL 3319
Query: 1200 EKKCQALSAADPGSDLFSVQAL--------QRRHEGFERDLVPLGDKVTILGETAERLSE 1251
C L + + Q L Q R + +++ + L E + L E
Sbjct: 3320 ---CTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE 3376
Query: 1252 SHP-DATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQ-NWISSIG 1309
P A E L++ E NE + + + E ++ A +A D + +WI+
Sbjct: 3377 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWIT--- 3433
Query: 1310 GMVSSQELAEDLTGI-EILLERHQEHRADMEAEAPTFQAL--EDFSAELIDSGHH---AS 1363
E + L + +I LE+ Q + T + L +D +L+ SGH A
Sbjct: 3434 ------ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3487
Query: 1364 PEIEKKLQAVKLER-----DDLEKAWEKRKKILDQCLEL-QMFQGNCDQVESWMVAREN- 1416
E EK+ KL++ D + + +R L++ L F +++ W+ ++
Sbjct: 3488 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI 3547
Query: 1417 ------------SLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADE 1464
+LR + E + + + +DK + ++ +L I ++
Sbjct: 3548 ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK-MNKTGPQLLELSPGEGFSIQEK 3606
Query: 1465 HYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTAC 1524
+ A + + ++++ + + + I + T+ D + Q LE + E + + +
Sbjct: 3607 YVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILESLERIVERLRQPPSISA 3664
Query: 1525 D-----ESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMK 1579
+ E + N+ K Q + R E++ + G + + SA +A++
Sbjct: 3665 EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM--IARSGGTDKDISA-----KAVQ 3717
Query: 1580 EQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQA--- 1636
++L+Q+ W+++ ++ KL + +FW ++ +KD
Sbjct: 3718 DKLDQMVFIWENIHTLVEEREAKLLDVMELAE--------KFWCDHMSLIVTIKDTQDFI 3769
Query: 1637 RDLASAG---NLLKKHQ----LLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK- 1688
RDL G +++K+ Q + E+ ++ L + L +L+++ IVKK
Sbjct: 3770 RDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSI 3829
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAY-ALFQFFQDLDDEESWIEEKLIRVSSQD-YGRDLQ 1746
D +N + ++ + +KL+EA A Q+ L W++ +++S G DL+
Sbjct: 3830 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 3889
Query: 1747 GVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEE--IQLRLAQFVEHWEKL 1804
V+ +++ K+ + E + ++ + AE L K ++ +Q L + W+ L
Sbjct: 3890 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 3949
Query: 1805 KELAKARGLKLEESLEYL-QFMQNAEEEEAWINE-KNALAVRGDCGDTLAATQSLLMKHE 1862
+E R KLE +L L QF +E AW+ + L+ + G A + L KH
Sbjct: 3950 EERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH 4009
Query: 1863 ALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKL 1922
L+ND H++ V+ V G D++ EE+ N + +K+E LN++ ++ + K
Sbjct: 4010 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN--LQNKLEVLNQRWQNVLEKTEQRKQ 4067
Query: 1923 QLEDDYAFQE---FNWKADVVEAWIADKETSLKTNGNGADLGD------------FLTLL 1967
QL D A ++ F+ + + ++ W+ D E L + L +
Sbjct: 4068 QL--DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFE 4125
Query: 1968 AKQDTLDASLQSFQQ--ERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASA 2025
AK++T + +Q QQ R P+ SA+ N I++ L ++WE +
Sbjct: 4126 AKEETYKSLMQKGQQMLARCPK---------SAETN----IDQDINNLKEKWESV----- 4167
Query: 2026 VHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDH 2085
KL E++ L++A +L +EF + NW + E+ L+ + + Q D
Sbjct: 4168 --ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDE 4225
Query: 2086 EDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVL----ERTWKHLSDIIEER 2141
A+ + + ++ELD+ L S + ++ L + W+ + + ER
Sbjct: 4226 HKVFANEVNSHRE--QIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVER 4283
Query: 2142 EQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSL--LKETGTLESQLEAN 2199
+ L ++AR + ++F + S ++W LE LD L + +++QL +
Sbjct: 4284 GRSL--DDAR-----KRAKQFHEAWSKLMEW-LEESEKSLDSELEIANDPDKIKTQLAQH 4335
Query: 2200 KRKQKEIQAMK----------RQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLG 2249
K QK + A R L + L D D L LD S L +WD +
Sbjct: 4336 KEFQKSLGAKHSVYDTTNRTGRSLKEKTSLAD---DNLKLDDMLSE--LRDKWDTICGKS 4390
Query: 2250 LRMQHNLEQQI 2260
+ Q+ LE+ +
Sbjct: 4391 VERQNKLEEAL 4401
Score = 130 bits (326), Expect = 2e-29
Identities = 246/1229 (20%), Positives = 521/1229 (42%), Gaps = 154/1229 (12%)
Query: 22 EEIQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIME---KVNILT 77
E +++ E RY+ + + ++ ++++ + Q F + AD WI E K+ L
Sbjct: 3384 EGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLG 3443
Query: 78 DKSYE-DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEET-KAHIEE 135
D E D T+ Q + QK + E+ ++ +L K+ + T +++ K +++
Sbjct: 3444 DIRLEQDQTSAQLQVQK--TFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK 3501
Query: 136 LRHLWDLLLELTLEKGDQLLRALKF-QQYVQECADILEWIGDKEAIATSVELGEDWERTE 194
+ +D + ++ E+ QL RA Q+ + ++ W+ + ++I + +L E
Sbjct: 3502 VLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS--QLPAPALEYE 3559
Query: 195 VLHKKFEDFQV--ELVAK-EGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRG 251
L ++ E+ + EL+A+ + + ++N+ + E + + IQ K + + +++
Sbjct: 3560 TLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3619
Query: 252 LALQRQKALSNAAN-------------------LQRFKRDVTEAIQWIKEKEPVLTSEDY 292
+R AL A + ++R ++ + + + K KE + +++
Sbjct: 3620 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNV 3679
Query: 293 GKDLVASEGLFHSHKGL-ERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSS 351
D+ + L+ + K E +A K++ AKA +Q+ + +V
Sbjct: 3680 SVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA-------------VQDKLDQMVFI 3726
Query: 352 WEHIRALATSRYEKL-QATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLD 410
WE+I L R KL +F D L + + I E P G + +
Sbjct: 3727 WENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP----GIDPSVV 3782
Query: 411 RHQQH-----KHEIDSYDDRFQSADETGQDLVNANHEASDE-VREKMEILDNNWTALLEL 464
+ QQ + EID + G +L+ A E V++ ++ L++ W +L +
Sbjct: 3783 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 3842
Query: 465 WDERHRQYEQCLDFHLFYRDSEQ-VDSWMSRQEAFLEN-EDLGNSLGSAEALLQKHEDFE 522
W +R + E+ + + Y+D Q V W+ L + +G L + + +++ + F+
Sbjct: 3843 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK 3902
Query: 523 EAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARR---DALREKAATRRRLLK 579
Q+ ++ ++ A L+ +S+ ++D L+ + D+L E+ R+ L+
Sbjct: 3903 SEAYQQQIEMERLNHQAELLLKKVTEESDK-HTVQDPLMELKLIWDSLEERIINRQHKLE 3961
Query: 580 ESLLLQKLYEDS-DDLKNWINKKKKLADDEDYK--DIQNLKSRVQKQQVFEKELAVNKTQ 636
+LL ++ + D+L W+ + L ++ D + ++ + K V + ++ +++
Sbjct: 3962 GALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQST 4021
Query: 637 LENIQKTGQEMIEG--GHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FE 693
+E + K G ++IE G AS N+ +L + W+ +LE T+Q+ QL A +Q + F
Sbjct: 4022 VEAVNKAGNDLIESSAGEEAS-NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFH 4080
Query: 694 NNAEDLQRWLEDVEWQVTSEDYGKGLAEV-QNRLRKHGLLESAVAARQDQVDILTDLAAY 752
EDLQ+WL D E + + GL E + +L H + +A A+++ L
Sbjct: 4081 GEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQ 4140
Query: 753 FEEIGHPDSKDIRARQE--SLVCRFEALKEPLATRKKKLLDLLHLQLICRDT-EDEEAWI 809
P S + Q+ +L ++E+++ L RK KL + L+L + ++ +D W+
Sbjct: 4141 MLA-RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWL 4199
Query: 810 QETEPS---ATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERG---------- 856
+ E + A+ L D + + ++ H+V + SH +I E+ + G
Sbjct: 4200 TQAEQTLNVASRPSLILDTVLFQ--IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQ 4257
Query: 857 --------------------NKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE 896
++VE G + +D R K ++ L + L+
Sbjct: 4258 DVVLIKNLLISVQSRWEKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4316
Query: 897 ANVQ-------FQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLN 949
+ ++ + LA E + + K + D TN G LK+ + D
Sbjct: 4317 SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN------RTGRSLKEKTSLADDNL 4370
Query: 950 SFGDSMKALRNQANAC------QQQQAAPVEGVAGE--QRVMALYDFQARSPREVTMKK- 1000
D + LR++ + +Q + +G+ + AL D+ R ++ +
Sbjct: 4371 KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP 4430
Query: 1001 --GDVLTLLSSI-NKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQ 1057
GD+ +++ I N ++ E V A ++R A + L + R++ + +
Sbjct: 4431 VHGDIDLVMNLIDNHKAFQKELGKRTSSVQA--LKRSARE----LIEGSRDDSSWVKVQM 4484
Query: 1058 EQIENQYRSLLDRAEERRRRL---LQRYNEFLLAYEAGDMLEWIQEKKAENT----GVEL 1110
+++ ++ ++ + ++ RL L++ EF A +LEW+ E AE T GV
Sbjct: 4485 QELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA--LLEWLAE--AEQTLRFHGVLP 4540
Query: 1111 DDVWELQKKFDEFQKDLNTNEPRLRDINK 1139
DD L+ D+ ++ + E + ++NK
Sbjct: 4541 DDEDALRTLIDQHKEFMKKLEEKRAELNK 4569
Score = 125 bits (314), Expect = 5e-28
Identities = 431/2270 (18%), Positives = 886/2270 (39%), Gaps = 316/2270 (13%)
Query: 273 VTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTL 332
V + + W+ E + L ++G DL + E +HK + R + +KE AK ++ +
Sbjct: 282 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQM 339
Query: 333 SHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKT-- 390
+ P +++ ++ + L TSR ++ ++ S +EL W+NEK
Sbjct: 340 TAPLKLTYAEKLHR---LESQYAKLLNTSRNQERHLDTLHNFVSRATNELI-WLNEKEEE 395
Query: 391 -AAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVRE 449
A + E T++A + D H + E+D ++ +S E + L+ NH A +
Sbjct: 396 EVAYDWSERNTNIARKK---DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEA 452
Query: 450 KMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENE---DLGN 506
+ W+ +L+L + ++ + F+ D+++ ++ + ++ + D +
Sbjct: 453 YRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS 512
Query: 507 SLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSE-------NIKAI--- 556
S+ E L+Q+ + +E + I + A +I +S+ IKAI
Sbjct: 513 SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDY 572
Query: 557 ---------RDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADD 607
D + ++ R K E+++ + K ++ ++ +
Sbjct: 573 RQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--E 630
Query: 608 EDYKDIQNL--KSRVQKQQVFEKELAVNKTQLENIQKTG----QEMIEGGHYASDNVTTR 661
+ Y+++ L +S + + V +N +++ I+ + + M+ G H
Sbjct: 631 QQYQNVLTLWHESHINMKSVVSWHYLIN--EIDRIRASNVASIKTMLPGEHQQV------ 682
Query: 662 LSEVASLWEELLEATKQKGTQLHEANQQLQFENNA--EDLQRWLEDVEWQVTSED-YGKG 718
LS + S +E+ LE +++ QL+ E N + Q L+ E + E Y
Sbjct: 683 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742
Query: 719 LAEVQN-RLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEA 777
++EV+N RLR LE+ +D+ ++ + E +S QE L E
Sbjct: 743 ISEVRNIRLR----LENC----EDR--LIRQIRTPLERDDLHESVFRITEQEKLKKELER 792
Query: 778 LKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY-LGKDLIASKKLLNRHR 836
LK+ L T K + + + + Y + I K +N
Sbjct: 793 LKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVN--- 849
Query: 837 VILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQ---N 893
++L+N + E ++ K+ EE A+ + +++L ++ R+ ++ +
Sbjct: 850 LVLKNTQAAEALVKLYE---TKLCEEEAVIAD--KNNIENLISTLKQWRSEVDEKRQVFH 904
Query: 894 DLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAF-------LL 946
LE +Q + ++D E + KE +D + +E A L+++ + L
Sbjct: 905 ALEDELQKAKAISD----EMFKTYKERDLD---FDWHKEKADQLVERWQNVHVQIDNRLR 957
Query: 947 DLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTL 1006
DL G S+K R+ + ++ V QR + + Q + + + + L
Sbjct: 958 DLEGIGKSLKYYRDTYHPLDDW----IQQVETTQR--KIQENQPENSKTLATQLNQQKML 1011
Query: 1007 LSSINKDWWKVE-----AADHQGIVPAVYVRRLAH-------DEFPMLPQRRREEPGNIT 1054
+S I K++ A + V ++ + + + P+ +R + I
Sbjct: 1012 VSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII 1071
Query: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVW 1114
Q + +Y +L+ L+ +Y +F AGD L+ ++E E +E ++
Sbjct: 1072 QEFMDLRTRYTALV--------TLMTQYIKF-----AGDSLKRLEE---EEKSLE-EEKK 1114
Query: 1115 ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADE 1174
E +K E QK ++ L+D K + ++ E ++E S +LQ +
Sbjct: 1115 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE--ALQTI--- 1169
Query: 1175 QRQLLGSAHAVEVFHREADDTKEQI------------EKKCQALSAADPGSDLFSVQALQ 1222
QL + H ++ E ++ ++Q+ E Q + G + +
Sbjct: 1170 --QLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVA 1227
Query: 1223 RRHEGFERDLVPLGDKVTILGETAERLSESHP-----DATEDLQRQKMELNEAWEDLQGR 1277
R + ++ L + D +L +T RL D T +L++ + + E +D+QG
Sbjct: 1228 ERQQEYKEKLQGICD---LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGS 1284
Query: 1278 TKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRAD 1337
+ E + + F ++ +S + Q+L E E L + ++ + +
Sbjct: 1285 AQALAEVVKNTENF------LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE 1338
Query: 1338 MEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLEL 1397
++ T E + + +IE L + D E+A K K++++Q
Sbjct: 1339 LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQ--NG 1396
Query: 1398 QMFQ--------GNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGK 1449
FQ G D+V ++ E + ++ ++L +K + I +Q
Sbjct: 1397 THFQEGDGKSAIGEEDEVNGNLL--ETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQA 1454
Query: 1450 ITDLEHFAESLIADE-HYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYAN-----LK 1503
+ A+ L+ + Y E +LQ+ + K + E K + L+
Sbjct: 1455 VIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELE 1514
Query: 1504 QFYRDLEELEEWI--SEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINL 1561
+F D E E W+ SE + D + K + ++F+ +V + +
Sbjct: 1515 KFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITIS 1574
Query: 1562 GNSLIE----CSACDGNE-------EAMKEQLEQLKEHWDHLLERTNDKGKKLNE-ASRQ 1609
GN ++E CS DG + ++ +L+ + + L + N G L + +
Sbjct: 1575 GNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY 1634
Query: 1610 QRFNTSIRDFEFWLSEAETLLA---MKDQARDLASAGNLLKKHQLLEREMLAREDALKDL 1666
Q + + L E + + A D + L++ + L+ ++ +++ A++ L
Sbjct: 1635 QHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKL 1694
Query: 1667 NTLAEDLLSS-GTF--NVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQD-L 1722
AE LL + G+ + I K D++ R+ ++ + +EKL+ QD L
Sbjct: 1695 KKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGL 1754
Query: 1723 DDEESWIEEKLIRVSSQDYGR---DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL 1779
D+ W+ + S ++ G+ + +Q+++ K+ LE ++ + +I + + +K
Sbjct: 1755 DEMLDWMGN--VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKF 1812
Query: 1780 KD-----KAAVGQEEIQLRLAQFVEHWEKLKE-LAKARGLKLEESLEYLQFMQNAEEEEA 1833
+ A+ Q +++ A+F E K KE LAK LK + L F +E+ +
Sbjct: 1813 METTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL----FENLSEKLQT 1868
Query: 1834 WINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEE 1893
++ K D S M+ ++F H+ ++ + + ++I + L +
Sbjct: 1869 FLETKTQALTEVDVPGKDVTELSQYMQEST--SEFLEHKKHLEVLHSLLKEISSHGLPSD 1926
Query: 1894 -----SQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKE 1948
+ +S K + + + +A+ + + QL+ AFQ +++WI KE
Sbjct: 1927 KALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLD---AFQVL---VKSLKSWI--KE 1978
Query: 1949 TSLKT-----NGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKD------KLIS 1997
T+ K + DLG L +DT LQ + PEI + + LIS
Sbjct: 1979 TTKKVPIVQPSFGAEDLGKSL-----EDT--KKLQEKWSLKTPEIQKVNNSGISLCNLIS 2031
Query: 1998 AQHNQSKAI-------------------EERYA--ALLKRWEQLLEAS-------AVHRQ 2029
A +KAI EE +A L + + + S + +
Sbjct: 2032 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2091
Query: 2030 KLLE---KQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHE 2086
K+ E K LQKA++ ++SA+ W +KM + ++ + + ++ E
Sbjct: 2092 KIAELNTKLSKLQKAQE-------ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVE 2144
Query: 2087 DFLASLARAQADFKCLLELDQQIKAL-----GVPSSPYTWLTVEVLERTWKHLSDIIEER 2141
+ A + + + EL ++ L P +P + ++ W+ L+ + +R
Sbjct: 2145 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2204
Query: 2142 EQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYF-LDGSLLKETGTLESQLEANK 2200
+Q+L+ E + + F+ + + QW++E + G L + L +Q + +
Sbjct: 2205 QQKLE-ESSNNLTQFQTVE------AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2257
Query: 2201 RKQKEIQAMKRQLTKIVDLGDNL-----EDALILDI-KYSTIGLAQQWDQLY-QLGLRMQ 2253
+E K Q ++ G + ED + I K + Q+WD L QL R
Sbjct: 2258 ILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCD 2317
Query: 2254 HNLEQQIQAKDIKGVS-EETLKEFSTIYKHFDENLTGRL---THKEFRSCLRGLNYYLPM 2309
++Q I +K + L+ S D L+ L TH + + + L M
Sbjct: 2318 W-IDQAI----VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN--QQLETAQKM 2370
Query: 2310 VEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENI-KSSDEIE 2358
+E + E K K A+ V E+Y + ++ E I KS ++E
Sbjct: 2371 KQEIQQEKKQIKVAQALCEDLSALVK-EEYLKAELSRQLEGILKSFKDVE 2419
Score = 124 bits (312), Expect = 9e-28
Identities = 433/2368 (18%), Positives = 888/2368 (37%), Gaps = 379/2368 (16%)
Query: 6 KETVVESSGPKVLETAEEIQERRQEV---LTRYQSFK----ERVAERGQKLEDSYHLQVF 58
K ++SS +++ +++ R + +T+Y F +R+ E + LE+ V
Sbjct: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVE 1118
Query: 59 KRDADDLGKWIMEKVNILTD--KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKT-- 114
K A +L KW+ L D K+ + P + K + E+ TK +SE +T
Sbjct: 1119 K--AKELQKWVSNISKTLKDAEKAGKPP------FSKQKISSEEISTKKEQLSEALQTIQ 1170
Query: 115 ---REERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADIL 171
+ M E + ++ L+ ++LL +LK Q Q D+
Sbjct: 1171 LFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS----------ESLKQLQESQTSGDVK 1220
Query: 172 EWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPD 231
+++ +A ER + +K + L E R++ + + +
Sbjct: 1221 V---EEKIVA---------ERQQEYKEKLQGICDLLTQTENRLIGHQEAF--MIGDGTVE 1266
Query: 232 LPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSED 291
L QSKQ E+ + ++G A + + N N ++KE L+ ED
Sbjct: 1267 LKKYQSKQEELQ---KDMQGSAQALAEVVKNTEN-------------FLKENGEKLSQED 1310
Query: 292 YGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSS 351
A++ K+ E K E+L L ++ ++
Sbjct: 1311 K---------------------ALIEQKLNEAKIKCEQLNLKAEQSKKELDKV------- 1342
Query: 352 WEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411
+ EK+ A + + L W++ N D+ ++ AG
Sbjct: 1343 ---VTTAIKEETEKVAAVKQLEESKTKIENLLDWLS------NVDK-DSERAG------- 1385
Query: 412 HQQHKHEIDSYDDRFQSADETG----QDLVNANHEASDEVREKMEILDNNWTALLELWDE 467
+HK I+ FQ D +D VN N +D + +N L + + +
Sbjct: 1386 -TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN----LNQQYQK 1440
Query: 468 RHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTA 527
Q+E+ + H Q + + SA+ LL+K + +
Sbjct: 1441 VKAQHEKIISQH---------------QAVIIATQ-------SAQVLLEKQGQY---LSP 1475
Query: 528 QEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKL 587
+E++ + + K+ HY++ ++ EK L+E L +K
Sbjct: 1476 EEKEKLQKNMKELKV----HYETALAES-------------EKKMKLTHSLQEEL--EKF 1516
Query: 588 YEDSDDLKNWINKKKKLADDEDY--KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQ 645
D + ++W+ + ++ ++ + DI L +++++Q+ F +++ +K L I +G
Sbjct: 1517 DADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGN 1576
Query: 646 EMIEGGHYASDN-------------VTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ- 691
++E S V +L + L G L + + Q
Sbjct: 1577 RVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQH 1636
Query: 692 FENNAEDLQRWLEDVEWQVT---SEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTD 748
+E+ + L L+ E + SE +Q +L + L+ ++++Q V+ L
Sbjct: 1637 YEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKK 1696
Query: 749 LAAYFEEIGH---PDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDE 805
A + P DI+ + +V R+E L + + R +KL L L +D DE
Sbjct: 1697 TAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 1756
Query: 806 EA-WIQETEPSATST-YLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEG 863
W+ E S + + A + +++++ ++ ++IA + I + E+ K +E
Sbjct: 1757 MLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETT 1816
Query: 864 HFAAEDVASRVKSLNQNMESLRARAAR----------RQNDLEANVQFQQYLADLHEAET 913
S SL M+ L AR + + +L+ V+ + L++ + +T
Sbjct: 1817 D------PSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE--KLQT 1868
Query: 914 WIREKEPIVDNTNY-GADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQ--ANACQQQQA 970
++ K + + G D +++ + L+ + + +L + ++ +A
Sbjct: 1869 FLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA 1928
Query: 971 APVEGVAGEQRVMALYDFQARSPREVT---MKKGDVLTLLSSINKDWWKVEAADHQGIVP 1027
+E + + + +E ++ D +L K W K VP
Sbjct: 1929 LVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKK----VP 1984
Query: 1028 AVYVRRLAHDEFPMLPQRRR--EEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEF 1085
V A D L ++ E+ T +++ N SL + + +
Sbjct: 1985 IVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA-----VTTPAKA 2039
Query: 1086 LLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLL 1145
+ A ++G + E T ++ W K L + + + DI+ +DL
Sbjct: 2040 IAAVKSGGAV-----LNGEGTATNTEEFWA--------NKGLTSIKKDMTDISHGYEDL- 2085
Query: 1146 FEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQA 1205
GLL + ELN++ LQ+ +E ++ +++ K
Sbjct: 2086 --GLLLKDKIA---ELNTKLSKLQKAQEESSAMM--------------QWLQKMNKTATK 2126
Query: 1206 LSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKM 1265
+D +V+ +++ FE +L +KV L + L E +PD E + ++M
Sbjct: 2127 WQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQM 2186
Query: 1266 --ELNEAWEDLQGRTKDRKESLNE-AQKFYLFLSKARDLQNW-------ISSIGGM-VSS 1314
E++ W++L T DR++ L E + F + L+ W +S +G + +
Sbjct: 2187 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP 2246
Query: 1315 QELAEDLTGIEILLERHQEHRADMEAEAPTFQAL-----EDFSAELIDSGHHASPEIEKK 1369
L ++ILL+ + E Q + ED S I ++++
Sbjct: 2247 NMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGI---------VKEQ 2297
Query: 1370 LQAVKLERDDLEKAWEKRKKILDQCL-ELQMFQGNCDQVESWMVARENSLRSDDKSSL-- 1426
L AV + D L R +DQ + + +Q + + +N L S S
Sbjct: 2298 LAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP 2357
Query: 1427 DSLEALMKKRDDLDKAITAQEGKITDLEHFAESL--IADEHYAKEEIATRLQRVLDRWKA 1484
D++ ++ + + I ++ +I + E L + E Y K E++ +L+ +L +K
Sbjct: 2358 DAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKD 2417
Query: 1485 LKAQLIDERTKL-GDYANLKQFYRDLEELEEWISEMLPTACDESYKD-----ATNIQRKY 1538
++ + + L A+ QF + + + W L T +E K ++
Sbjct: 2418 VEQKAENHVQHLQSACASSHQFQQMSRDFQAW----LDTKKEEQNKSHPISAKLDVLESL 2473
Query: 1539 LK-HQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE-AMKEQLEQLKEHWDHLLERT 1596
+K H+ F+ + +S I G +L+ G+E+ A++ QL +K +WD ++
Sbjct: 2474 IKDHKDFSKTLTAQSHMYEKTIAEGENLL--LKTQGSEKAALQLQLNTIKTNWDTFNKQV 2531
Query: 1597 NDKGKKLNEA-SRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLERE 1655
++ KL E+ + ++ + W+ + + L D A N + K + L++E
Sbjct: 2532 KERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKE 2591
Query: 1656 MLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYAL 1715
M ++ LN A LLS + + + + ++ ++ V E + L+
Sbjct: 2592 MDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK 2651
Query: 1716 FQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775
F+ FQ++ E + +L Q D G Q K+ + A+++ +D+
Sbjct: 2652 FKEFQEVSKES---KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDL 2708
Query: 1776 AEKLKDKAAV------GQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829
A++L V G ++ L++ + L + + LE L+ + QN
Sbjct: 2709 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 2768
Query: 1830 EE-----EAWINEKNALAVRGDCGDTL----AATQSLLMKHEAL--ENDFAVHETRVQNV 1878
E + +E +++A G +TL ++ L K EAL ND A ++
Sbjct: 2769 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM-- 2826
Query: 1879 CAQGEDILNKVLQEESQNKEISSK--IEALNEKTPSLAKAIAAWKLQLEDDY-AFQEFNW 1935
+ EE+ + K +EAL+++ L A + Q+E +EF
Sbjct: 2827 ----------LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYS 2876
Query: 1936 KADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDK- 1994
K + E ++ G + + +T++ L F+ + EI L+ K
Sbjct: 2877 KLKEFSILLQKAEEHEESQG---------PVGMETETINQQLNMFKVFQKEEIEPLQGKQ 2927
Query: 1995 ---------LI--SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAED 2043
LI +A+ ++ +E + RW+ L +K+ ++ LQ+A
Sbjct: 2928 QDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL-------NKKVAQRAAQLQEALL 2980
Query: 2044 LFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLA-RAQADFKCL 2102
F +L +W EE ++ + ++ + Q + L L ++ + +
Sbjct: 2981 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3040
Query: 2103 LELDQQIKALGVPSSPYTWL-TVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQE 2161
++I P+ L + +L+ W+ L + E R ++L+ + Q+
Sbjct: 3041 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISV-------VAQQ 3093
Query: 2162 FEQNASTFLQWILETRAYFLDGSLL-KETGTLESQLEANKRKQKEIQAMKRQLTKIVDLG 2220
F + +W+ ++ + + LE Q+ +K + +I + L + V +G
Sbjct: 3094 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3153
Query: 2221 DNL------EDALILDIKYSTIGLAQQW 2242
+L ED D+ S + +Q W
Sbjct: 3154 QSLKVLSSREDK---DMVQSKLDFSQVW 3178
Score = 122 bits (306), Expect = 4e-27
Identities = 304/1638 (18%), Positives = 627/1638 (38%), Gaps = 208/1638 (12%)
Query: 16 KVLETAEE---IQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIME 71
KVL + E+ +Q + Y +E+ R + L+ + + ++F D +L W+ E
Sbjct: 3157 KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNE 3216
Query: 72 KVNILTDKSYEDPTNIQGKYQKHQSLEA--------EVQTKSRLMSELE---KTREERFT 120
+ L+ S +D + +G +++ L + L++ LE +T +
Sbjct: 3217 VHDKLSKLSVQDYST-EGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL 3275
Query: 121 MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAI 180
+ E KA +++ L + + TLE+ QL R L ++ W+ E
Sbjct: 3276 IIQDKLEAIKARYKDITKLSTDVAK-TLEQALQLARRLHSTH-----EELCTWLDKVEVE 3329
Query: 181 ATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYA-----NECAEENHPDLPL- 234
S E T+VL K E Q ++ KE + N A NE + +P
Sbjct: 3330 LLSYE-------TQVL-KGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWR 3381
Query: 235 ----IQSKQNEVNAAWERLRGLALQRQKALSNAA-NLQRFKRDVTEAIQWIKEKEPVLTS 289
++ E N + + Q+ + + A Q+F + + WI E E L S
Sbjct: 3382 AREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMS 3441
Query: 290 -EDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDL 348
D + + K + D + +L K+ + + Q + K D
Sbjct: 3442 LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK 3501
Query: 349 V-SSWEHIRALATSRYEKLQ-ATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGE 406
V +++ I + + RY +L+ A ++F ++EL W+ E + I+ +LP E
Sbjct: 3502 VLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS--QLPAPALEYE 3559
Query: 407 VLLDRHQQHKHE---IDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLE 463
L + ++H+ I + ++TG L+ + ++EK D ++ + E
Sbjct: 3560 TLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3619
Query: 464 LWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEE 523
+R ++ + + D ++D + E +E S+ + +++ +
Sbjct: 3620 DVKKRAVALDEAISQSTQFHD--KIDQILESLERIVERLRQPPSISAEVEKIKEQISENK 3677
Query: 524 AFTAQEEKII----TVDKTATKLIGDDHYDSENI--KAIRDGLLAR-------RDALREK 570
+ EK+ T+ + ++I ++I KA++D L + E+
Sbjct: 3678 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 3737
Query: 571 AATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQN--LKSRVQKQQVFEK 628
A +LL L +K + D L I + D + I +K + + + +
Sbjct: 3738 EA---KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 3794
Query: 629 ELAVNKTQLENIQKTGQEMIEG-GHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEAN 687
E+ + +L+ + G E+I G V + E+ S W+ L +A K + +L EA
Sbjct: 3795 EIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAM 3854
Query: 688 QQ-LQFENNAEDLQRWLEDVEWQVTS-EDYGKGLAEVQNRLRKHGLLESAVAARQDQVDI 745
Q +Q+++ + + W++ ++ S G L V+ ++ + +S +Q +++
Sbjct: 3855 QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER 3914
Query: 746 LTDLAAYF--EEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLD-LLHLQLICRDT 802
L A + D ++ L +++L+E + R+ KL LL L
Sbjct: 3915 LNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHAL 3974
Query: 803 EDEEAWIQETEPSATSTY-LGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVE 861
++ AW+ TE + +G D A + L +H V+ ++ +H+ ++ + + GN ++E
Sbjct: 3975 DELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIE 4034
Query: 862 -EGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANV-QFQQYLADLHEAETWIREKE 919
A ++ ++++ LNQ +++ + +R+ L+ + Q + + ++ + + W+ + E
Sbjct: 4035 SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTE 4094
Query: 920 -PIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAG 978
++ + G E A L H + ++ K+L + G
Sbjct: 4095 RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQK----------------G 4138
Query: 979 EQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDE 1038
+Q + AR P+ + ++ ++++ + W VE ++ LA +
Sbjct: 4139 QQML-------ARCPKSA---ETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEF 4188
Query: 1039 FPMLPQ-----RRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGD 1093
L + E+ N+ R I + +D + + + + + G
Sbjct: 4189 HNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGT 4248
Query: 1094 MLEWIQEKK----AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGL 1149
L++ +K+ +N + + WE KV L+ G
Sbjct: 4249 HLKYFSQKQDVVLIKNLLISVQSRWE-----------------------KVVQRLVERGR 4285
Query: 1150 LTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAA 1209
+ + ++ + W L +E + L S + A
Sbjct: 4286 SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEI----------------------AN 4323
Query: 1210 DPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKM--EL 1267
DP D Q Q H+ F++ L T L E A ++L+ M EL
Sbjct: 4324 DP--DKIKTQLAQ--HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4379
Query: 1268 NEAWEDLQGRTKDRKESLNEAQKFY-LFLSKARDLQNWISSI-GGMVSSQELAEDLTGIE 1325
+ W+ + G++ +R+ L EA F F + L +W+ + + Q + D+ +
Sbjct: 4380 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4439
Query: 1326 ILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWE 1385
L++ H+ + ++ + QAL+ + ELI+ S VK++ +L WE
Sbjct: 4440 NLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-------SWVKVQMQELSTRWE 4492
Query: 1386 --------KRKKILDQCLELQMFQGNCDQVESWMVARENSLR-----SDDKSSLDSL--- 1429
K+ ++ + + F + W+ E +LR DD+ +L +L
Sbjct: 4493 TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ 4552
Query: 1430 -----EALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKA 1484
+ L +KR +L+KA T + + +S+ +H+ I R + VL K
Sbjct: 4553 HKEFMKKLEEKRAELNKATTMGDTVLAICH--PDSITTIKHWI-TIIRARFEEVLAWAKQ 4609
Query: 1485 LKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESY----KDATNIQRKYLK 1540
+ +L A L LE L W+ T D+ ++ ++ +
Sbjct: 4610 HQQRLASA------LAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE 4663
Query: 1541 HQTFAHEVDGRSEQVHGV 1558
HQTF E+ + V V
Sbjct: 4664 HQTFMEEMTRKQPDVDKV 4681
Score = 105 bits (262), Expect = 5e-22
Identities = 429/2370 (18%), Positives = 878/2370 (37%), Gaps = 423/2370 (17%)
Query: 187 GEDWERTEVLHKKFEDF----QVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNE- 241
GE + L +FEDF Q V + ++ + N C + L + ++ E
Sbjct: 677 GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEE 736
Query: 242 --VNAAWERLRGLALQRQKALSNAANLQRF---KRDVTEAIQWIKEKEPVLTSEDYGKDL 296
N +R + L+ + R + D+ E++ I E+E + + KD
Sbjct: 737 SVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD- 795
Query: 297 VASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIR 356
+L +++K +E ++A + S P ++ ++ + +
Sbjct: 796 ---------------DLGTITNKCEEFFSQA-----AASSSVPTLRSELNVVLQNMNQVY 835
Query: 357 ALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHK 416
+++++ +KL+ + + + L K A + D E L+ +Q +
Sbjct: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA--VIADKNNIENLISTLKQWR 893
Query: 417 HEID-------SYDDRFQSADETGQDLVNANHEAS---DEVREKMEILDNNWTALLELWD 466
E+D + +D Q A ++ E D +EK + L W + D
Sbjct: 894 SEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 953
Query: 467 ERHRQYEQCLDFHLFYRDS-EQVDSWMSRQEAF---LENEDLGNSLGSAEALLQKHEDFE 522
R R E +YRD+ +D W+ + E ++ NS A L Q
Sbjct: 954 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQ------ 1007
Query: 523 EAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLL------ARRDALREKAATRRR 576
Q+ + ++ +K+ Y + ++D L A D+ ++ RRR
Sbjct: 1008 -----QKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRR 1062
Query: 577 LLKESLLLQKLYED-------------------SDDLKNWINKKKKLADD-----EDYKD 612
+ + L+ + + D D LK ++K L ++ E K+
Sbjct: 1063 MQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKE 1122
Query: 613 IQNLKSRVQK---------------QQVFEKELAVNKTQLEN--------IQKTGQEMIE 649
+Q S + K Q++ +E++ K QL + K G +M +
Sbjct: 1123 LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTD 1182
Query: 650 GGHYASDNVTTRLSEVASLW-----EELLEATKQKGTQLHE---ANQQLQFENNAEDLQR 701
+ L E +L ++L E+ ++ E A +Q +++ + +
Sbjct: 1183 EERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICD 1242
Query: 702 WLEDVEWQVTSED----YGKGLAEVQNRLRKHGLLESAV-AARQDQVDILTDLAAYFEEI 756
L E ++ G G E++ K L+ + + Q +++ + + +E
Sbjct: 1243 LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1302
Query: 757 GHPDSKDIRARQESLVCRFEALKEPL---ATRKKKLLDLLHLQLICRDTEDEEAWIQETE 813
G S++ +A E + + E L A + KK LD + I +TE A +++ E
Sbjct: 1303 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA-VKQLE 1361
Query: 814 PSATSTYLGKDLIA-----SKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAE 868
S T D ++ S++ +H+ ++E +H + G + G+
Sbjct: 1362 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1421
Query: 869 DVASRV----KSLNQNMESLRARAARRQNDLEANV---QFQQYLADLHEAETWIREKEPI 921
DV +V ++LNQ + ++A+ + + +A + Q Q L + EKE +
Sbjct: 1422 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1481
Query: 922 VDN-----TNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGV 976
N +Y + +K + +L F + +Q+ G
Sbjct: 1482 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 1541
Query: 977 AGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQ--GIVPAVYVRRL 1034
+M Q +V KGD+ + S N+ ++ + G V R
Sbjct: 1542 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHRE 1601
Query: 1035 AHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDM 1094
+ R R ++ + + N + L+D+ Q Y + AG
Sbjct: 1602 VQRKLDHATDRFR----SLYSKCNVLGNNLKDLVDK--------YQHYEDASCGLLAGLQ 1649
Query: 1095 LEWIQEKKAENTGVELDDVWELQKKFDE---FQKDLNTNEPRLRDINKVADDLL-FEGLL 1150
K + + +D LQ++ +E Q +++ + + + K A+ LL G L
Sbjct: 1650 ACEATASKHLSEPIAVDPK-NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSL 1708
Query: 1151 TPEGAQIRQELNS---RWGSLQRLADEQRQ----LLGSAHAVEVFHREADDTKEQIEKKC 1203
P I++ L+ R+ L + +E+ + L + +V+ E D +E
Sbjct: 1709 LPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL 1768
Query: 1204 QALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSES-HPDATEDLQR 1262
+ S ++Q + ++ E+D+ + + E ++ E+ P LQ
Sbjct: 1769 KEQGQVPLNST--ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQA 1826
Query: 1263 QKMELNEAWEDLQGRTKDRKESLNEAQ-KFYLFLSKARDLQNWISSIGGMVSSQELAE-D 1320
+ +L+ + + + K+ + E + K LF + + LQ ++ + +Q L E D
Sbjct: 1827 KMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLET-----KTQALTEVD 1881
Query: 1321 LTGIEI--LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIE-KKLQAVKLER 1377
+ G ++ L + QE ++ + L E+ G + + +K + +
Sbjct: 1882 VPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKF 1941
Query: 1378 DDLEKAWEKRKKILDQCLE-LQMFQGNCDQVESWMV--------------------AREN 1416
++E +++K+ + C E L FQ ++SW+ + E+
Sbjct: 1942 KEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLED 2001
Query: 1417 SLRSDDKSSLDSLEALMKKRDDLD------------KAITAQEGKITDLEHFAESLIADE 1464
+ + +K SL + E + KAI A + L + +E
Sbjct: 2002 TKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEE 2061
Query: 1465 HYA-------KEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWIS 1517
+A K+++ D LK ++ + TKL + L++ + + +W+
Sbjct: 2062 FWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL---SKLQKAQEESSAMMQWLQ 2118
Query: 1518 EMLPTACD----ESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDG 1573
+M TA + D ++ + ++++F E+ +V + + L+E +
Sbjct: 2119 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2178
Query: 1574 NEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQ-QRFNTSIRDFEFWLSEAETLLAM 1632
K+ L ++ W L + T D+ +KL E+S +F T + WL E E ++++
Sbjct: 2179 EAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV 2238
Query: 1633 KDQARDLASAGNLL----KKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688
L+ N+L ++ Q+L +E R+ + L + +LS +
Sbjct: 2239 ---LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS----------RPG 2285
Query: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748
++ + R + ++LAA + L D WI++ +++ S Y L+ +
Sbjct: 2286 EDPSLRGIVKEQLAAVTQK-------WDSLTGQLSDRCDWIDQAIVK--STQYQSLLRSL 2336
Query: 1749 QNLLKK-HKRLEGELV--AHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLK 1805
+ L +L L H A+ L+ A+K+K + + QE+ Q+++AQ + E L
Sbjct: 2337 SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE--IQQEKKQIKVAQAL--CEDLS 2392
Query: 1806 ELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALE 1865
L K LK E S + + +L + +E
Sbjct: 2393 ALVKEEYLKAELSRQ---------------------------------LEGILKSFKDVE 2419
Query: 1866 NDFAVHETRVQNVCAQGEDILNKVLQEESQNKE--ISSKIEALNEKTPSLAKAIAAWKLQ 1923
H +Q+ CA Q+ S++ + + +K E N+ P A
Sbjct: 2420 QKAENHVQHLQSACASSHQ-----FQQMSRDFQAWLDTKKEEQNKSHPISA--------- 2465
Query: 1924 LEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQE 1983
K DV+E+ I D + KT + QS E
Sbjct: 2466 ------------KLDVLESLIKDHKDFSKT---------------------LTAQSHMYE 2492
Query: 1984 RLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAED 2043
+ I + ++ L+ Q ++ A++ + + W+ +++ E++ L+++ +
Sbjct: 2493 K--TIAEGENLLLKTQGSEKAALQLQLNTIKTNWD-------TFNKQVKERENKLKESLE 2543
Query: 2044 LFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLL 2103
+++ + L W +K + NL E C+ + E+ +A L Q
Sbjct: 2544 KALKYKEQVETLWPWIDKCQNNLEEIKFCLD-------PAEGENSIAKLKSLQK------ 2590
Query: 2104 ELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFE 2163
E+DQ VE+L T L + E ++ + E ++ +M E
Sbjct: 2591 EMDQHFG------------MVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE-- 2636
Query: 2164 QNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL 2223
L ++ + L+ T + E +K ++++Q K QL D+ D+L
Sbjct: 2637 ---------QLHSKKFCLENM----TQKFKEFQEVSKESKRQLQCAKEQL----DIHDSL 2679
Query: 2224 EDALILDIKYSTIGLAQQWD---QLYQLGLRMQHNLEQQIQAKDIKGVSEETL------K 2274
+ KY T+ QQ +Q+ L + + ++A D KG S+ L +
Sbjct: 2680 GSQAYSN-KYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQ 2738
Query: 2275 EFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHE-PKFEKFLDAVDPGRKGY 2333
E ST+ + DE + T L+G+ ++ + E + +F+ LD++ P +
Sbjct: 2739 EHSTLSQQVDEKCSFLETK------LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 2792
Query: 2334 VSL----EDYTAFLIDKESENIKSSDEIEN 2359
+L E AFL K+ E + +S++ N
Sbjct: 2793 ETLQKQKETIKAFL--KKLEALMASNDNAN 2820
Score = 90.1 bits (222), Expect = 2e-17
Identities = 319/1812 (17%), Positives = 680/1812 (37%), Gaps = 242/1812 (13%)
Query: 697 EDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAV--------AARQDQVDILTD 748
+DL W+++++ Q+ ++G L V++ L H + A+ A+ ++ +
Sbjct: 283 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP 342
Query: 749 LAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAW 808
L + E H R ES + + +++ LD LH + R T +E W
Sbjct: 343 LKLTYAEKLH--------RLESQYAKL----LNTSRNQERHLDTLH-NFVSRAT-NELIW 388
Query: 809 IQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAE 868
+ E E + + + + H ++ + E I+ + E +++ E H A
Sbjct: 389 LNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 448
Query: 869 DVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYG 928
+ + ++ + + ++ N + ++ D EA ++R + + Y
Sbjct: 449 TIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR-KYS 507
Query: 929 ADEEAAGALLK--------------KHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVE 974
D ++ L+ ++++ + +L ++ L+ + + C + + P++
Sbjct: 508 CDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIK 567
Query: 975 GVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKV-EAADHQGIVPAVYVRR 1033
+ +++ E+T+ K D L ++ ++ WKV ++ +VP+V
Sbjct: 568 AICDYRQI------------EITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVC--- 612
Query: 1034 LAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGD 1093
F + P + E ++ R IE QY+++L E + + L E
Sbjct: 613 -----FTVPPPNK--EAVDLANR---IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDR 662
Query: 1094 M-LEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTP 1152
+ + K G + LQ +F++F +D ++ +F G
Sbjct: 663 IRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQ-------------VFSG---S 706
Query: 1153 EGAQIRQELNSRWGSLQRL-----ADEQRQLLGSAHAVEV--FHREADDTKEQIEKKCQA 1205
+ Q+ +E+N Q L +EQ + + + + EV ++ ++++ ++ +
Sbjct: 707 DITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766
Query: 1206 -LSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQK 1264
L D +F + ++ + ER LG TI + E S++ A+ + +
Sbjct: 767 PLERDDLHESVFRITEQEKLKKELERLKDDLG---TITNKCEEFFSQA--AASSSVPTLR 821
Query: 1265 MELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQE-LAEDLTG 1323
ELN +++ +++ + L L + + + + +E + D
Sbjct: 822 SELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNN 881
Query: 1324 IEILLERHQEHRADMEAEAPTFQALED---FSAELIDSGHHASPEIEKKLQAVKLERDDL 1380
IE L+ ++ R++++ + F ALED + + D E + K + D L
Sbjct: 882 IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 941
Query: 1381 EKAWEKRKKILDQCL--------ELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEAL 1432
+ W+ +D L L+ ++ ++ W+ E + R ++ ++ + L
Sbjct: 942 VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTL 1001
Query: 1433 ---MKKRDDLDKAITAQEGKITDLEHFAESLIAD-EHYAKEEIATRLQRVLDRWKALKAQ 1488
+ ++ L I ++ K+ + + +AE A + Y + + R + +K +
Sbjct: 1002 ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR 1061
Query: 1489 LIDERTKL--GDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAH 1546
+ L ++ +L+ Y L L + + ++ +++ + +H A
Sbjct: 1062 RMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAK 1121
Query: 1547 E----VDGRSEQVHGVINLGNSLIECSACDGNE-EAMKEQLEQLKEHWDHLLERTNDKGK 1601
E V S+ + G E KEQL + + L + DK
Sbjct: 1122 ELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMT 1181
Query: 1602 KLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLARED 1661
+++ T + SE+ L + D+ ++ + Q +E L
Sbjct: 1182 DEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKL---Q 1238
Query: 1662 ALKDLNTLAED---------LLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEA 1712
+ DL T E+ ++ GT + + K++ + K ++Q A A E +K
Sbjct: 1239 GICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQK---DMQGSAQALAEVVK-- 1293
Query: 1713 YALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNV 1772
+ E++++E ++S +D Q + K ++L + + + V
Sbjct: 1294 -----------NTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKV 1342
Query: 1773 LDMA--EKLKDKAAVGQ-EEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829
+ A E+ + AAV Q EE + ++ ++ + + ++ G K ++ +E
Sbjct: 1343 VTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEG 1402
Query: 1830 EEEAWINEKNAL-------AVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQG 1882
+ ++ I E++ + V G G T K +A +++ + + + + Q
Sbjct: 1403 DGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA-QHEKIISQHQAVIIATQS 1461
Query: 1883 EDIL----NKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKAD 1938
+L + L E + K + E +LA++ KL ++F+
Sbjct: 1462 AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYT 1521
Query: 1939 VVEAWIADKETSLKTNGNGA-DLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLIS 1997
E W+ E L+ GA D+ +T L +Q +SF ++ + DL+ IS
Sbjct: 1522 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQ-------KSFSEDVISHKGDLRYITIS 1574
Query: 1998 AQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNN 2057
+ E + KR ++ SA HR E Q L A D F K + L N
Sbjct: 1575 GNR-----VLEAAKSCSKRDGGKVDTSATHR----EVQRKLDHATDRFRSLYSKCNVLGN 1625
Query: 2058 ------------------------WCE-KMEENLSEPVHCVSLNEIRQLQ--KDHEDFLA 2090
CE ++LSEP+ N RQL+ K + ++
Sbjct: 1626 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQIS 1685
Query: 2091 SLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEA 2150
S A K E+ + +P+ T++ + ++ LS + ER ++LQ
Sbjct: 1686 SQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLT 1745
Query: 2151 RQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEAN-KRKQKEIQAM 2209
R + + E + E L+ + L++ + LE + +Q I AM
Sbjct: 1746 RSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAM 1805
Query: 2210 KRQLTKIVDLGDNLEDALI------LDIKYSTIG------------LAQQWDQLYQLGLR 2251
++ K ++ D + + L ++S L + + L +
Sbjct: 1806 NEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEK 1865
Query: 2252 MQHNLEQQIQA---KDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLP 2308
+Q LE + QA D+ G K+ + + ++ E+ + L HK+ L L
Sbjct: 1866 LQTFLETKTQALTEVDVPG------KDVTELSQYMQESTSEFLEHKKHLEVLHSL----- 1914
Query: 2309 MVEEDEHEPKFEK--FLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALAE 2366
+ E H +K L+ + K + +ED I ++ E + S E +AFQ L +
Sbjct: 1915 LKEISSHGLPSDKALVLEKTNNLSKKFKEMED----TIKEKKEAVTSCQEQLDAFQVLVK 1970
Query: 2367 GKSYITKEDMKQ 2378
KE K+
Sbjct: 1971 SLKSWIKETTKK 1982
Score = 69.7 bits (169), Expect = 3e-11
Identities = 423/2395 (17%), Positives = 896/2395 (37%), Gaps = 430/2395 (17%)
Query: 68 WIMEKVN--ILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSA 125
W+ EK + D S E TNI K H L E+ K + +++ E+ H A
Sbjct: 388 WLNEKEEEEVAYDWS-ERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPA 446
Query: 126 HEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGD-KEA----- 179
+A+ ++ W +L+L +Q+++E E+ D KEA
Sbjct: 447 RLTIEAYRAAMQTQWSWILQL----------CQCVEQHIKENTAYFEFFNDAKEATDYLR 496
Query: 180 -IATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSK 238
+ +++ +R+ +HK + Q + KE E+ QY + A +IQ K
Sbjct: 497 NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKE----ELLQYKSTIANLMGKAKTIIQLK 552
Query: 239 QNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVA 298
+ + + KA+ + ++ I K+ E VL +
Sbjct: 553 PRNSDCPLKTSIPI-----KAICDYRQIE---------ITIYKDDECVLAN--------- 589
Query: 299 SEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRAL 358
+SH+ + ++ ++ A + + P + ++ + ++++ L
Sbjct: 590 -----NSHRAKWKVISPTGNE-----AMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL 639
Query: 359 ATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHE 418
+ +++ +H ++ D + A N + T + G +H+
Sbjct: 640 WHESHINMKSVVSWHYLINEIDRI--------RASNVASIKTMLPG---------EHQQV 682
Query: 419 IDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDF 478
+ + RF+ E Q+ + ++ +++ + + LL+ ER Q E +
Sbjct: 683 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKS-AEREEQEESVYNL 741
Query: 479 HLF------YRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKI 532
++ R D + + LE +DL S+ + + E ++ ++ +
Sbjct: 742 YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESV----FRITEQEKLKKELERLKDDL 797
Query: 533 ITVDKTATKLIGDDHYDSE--NIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYED 590
T+ + S +++ + +L + + ++T LK L+ K +
Sbjct: 798 GTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA 857
Query: 591 SDDLKNWINKKKKLADDE----DYKDIQNLKSRV--------QKQQVF---EKELAVNKT 635
++ L + KL ++E D +I+NL S + +K+QVF E EL K
Sbjct: 858 AEALVKLY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKA 915
Query: 636 QLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FEN 694
+ + KT +E D + ++ W+ + + L + L+ + +
Sbjct: 916 ISDEMFKTYKER----DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRD 971
Query: 695 NAEDLQRWLEDVE--WQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAY 752
L W++ VE + E+ + + +L + +L S + +Q ++D A
Sbjct: 972 TYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ 1031
Query: 753 FEEI----------------GHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQ 796
+ S R R +S L TR L+ L+
Sbjct: 1032 YSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQY 1091
Query: 797 LICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERG 856
+ + D ++E E S K+ + + + + + +++ +++ + G
Sbjct: 1092 I--KFAGDSLKRLEEEEKSLEE--------EKKEHVEKAKELQKWVSNISKTLKDAEKAG 1141
Query: 857 NKMVEEGHFAAEDVASRVKSLNQNMESLRARAAR--------RQNDLEA---------NV 899
+ ++E+++++ + L++ +++++ A+ +N+LE N+
Sbjct: 1142 KPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNL 1201
Query: 900 QFQQYLADLHEAETW--IREKEPIVDNTNYGADEEAAG----------ALLKKHEAFLLD 947
F + L L E++T ++ +E IV E+ G L+ EAF++
Sbjct: 1202 LFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI- 1260
Query: 948 LNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLL 1007
GD L+ Q +Q + + G + +A EV + L
Sbjct: 1261 ----GDGTVELKKY----QSKQEELQKDMQGSAQALA----------EVVKNTENFL--- 1299
Query: 1008 SSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSL 1067
++ K+ D I + ++ ++ + ++ ++E + + E + +
Sbjct: 1300 ---KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA 1356
Query: 1068 LDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQ--EKKAENTGVELDDVWELQKKFDEFQK 1125
+ + EE + ++ ++L+W+ +K +E G + V +++ FQ+
Sbjct: 1357 VKQLEESKTKI-------------ENLLDWLSNVDKDSERAGTKHKQV--IEQNGTHFQE 1401
Query: 1126 DLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAV 1185
+ + + ++V +LL E + + ++ LN ++ Q++ + +++ AV
Sbjct: 1402 --GDGKSAIGEEDEVNGNLL-ETDVDGQVGTTQENLNQQY---QKVKAQHEKIISQHQAV 1455
Query: 1186 EVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGET 1245
+ + A + +EK+ Q LS + +++ L+ +E L K+ +
Sbjct: 1456 IIATQSA---QVLLEKQGQYLSPEEKEKLQKNMKELKVH---YETALAESEKKMKLTHSL 1509
Query: 1246 AERLSESHPDATED---LQRQKMELNE---AWEDLQG------RTKDRKESL--NEAQKF 1291
E L + D TE LQ+ + EL +D+ G R K E + ++
Sbjct: 1510 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1569
Query: 1292 YLFLSKARDLQ---NWISSIGGMVSSQELAEDLTGIEILLERHQEHRAD-MEAEAPTFQA 1347
Y+ +S R L+ + GG V D + ++R +H D +
Sbjct: 1570 YITISGNRVLEAAKSCSKRDGGKV-------DTSATHREVQRKLDHATDRFRSLYSKCNV 1622
Query: 1348 LEDFSAELIDSGHH---ASPEIEKKLQAVK--LERDDLEKAWEKRKKILDQCLELQMFQG 1402
L + +L+D H AS + LQA + + E K + Q E + QG
Sbjct: 1623 LGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQG 1682
Query: 1403 NCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIA 1462
Q+ S VA E L+ + LD+ +L+ ++D+ K + G+ DL S
Sbjct: 1683 ---QISSQQVAVE-KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDL-----SKSV 1733
Query: 1463 DEHYAKEEIA-TRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLP 1521
+E K +I TR V D L+E+ +W+ +
Sbjct: 1734 NERNEKLQITLTRSLSVQD---------------------------GLDEMLDWMGNVES 1766
Query: 1522 TACDESY--KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMK 1579
+ ++ ++T +Q K+ ++ GR ++ AM
Sbjct: 1767 SLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSIN--------------------AMN 1806
Query: 1580 EQLEQLKEHWD-----HLLERTNDKGKKLNEAS--------RQQRFNTSIRDFEFWLSEA 1626
E++++ E D L + D + +EAS + + T + FE +
Sbjct: 1807 EKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKL 1866
Query: 1627 ETLLAMKDQA--------RDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGT 1678
+T L K QA +D+ +++ E L + L+ L++L +++ S G
Sbjct: 1867 QTFLETKTQALTEVDVPGKDVTELSQYMQES---TSEFLEHKKHLEVLHSLLKEISSHGL 1923
Query: 1679 FNVDQIV-KKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDL-DDEESWIEEKLIRV 1736
+ +V +K +N++K+F +++ E + FQ L +SWI+E +V
Sbjct: 1924 PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV 1983
Query: 1737 SSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL-----------KDKAAV 1785
+ + L+ K+L+ + P IQ V + L K AAV
Sbjct: 1984 PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAV 2043
Query: 1786 -----------------------GQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYL 1822
G I+ + +E L L K + +L L L
Sbjct: 2044 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL 2103
Query: 1823 QFMQNAEEEEA----WINEKNALAVRGDCGDTLAATQSLLMKHEALEN-DFAVHETRVQN 1877
Q A+EE + W+ + N A + T A T + +K + +N F + N
Sbjct: 2104 ---QKAQEESSAMMQWLQKMNKTATKWQ--QTPAPTDTEAVKTQVEQNKSFEAELKQNVN 2158
Query: 1878 VCAQGEDILNKVLQEESQN----------KEISSKIEALNEKTPSLAKAIAAWKLQLEDD 1927
+ +D L ++L+E EI SK + LN+ T + + E
Sbjct: 2159 KVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE------ESS 2212
Query: 1928 YAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSF--QQERL 1985
+F ++ W+ +KE + G + + L +Q + LQ F ++ +
Sbjct: 2213 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQ--VQILLQEFATRKPQY 2270
Query: 1986 PEITDLKDKLISAQHNQSK---AIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE 2042
++T ++S ++E+ AA+ ++W+ L + + + + + +
Sbjct: 2271 EQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQ 2330
Query: 2043 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLN-EIRQLQKDHEDFLASLARAQADFKC 2101
L + K S L+N K+ +L+ H ++N ++ QK ++ + + + K
Sbjct: 2331 SLLRSLSDKLSDLDN---KLSSSLAVSTHPDAMNQQLETAQKMKQE----IQQEKKQIKV 2383
Query: 2102 LLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQE 2161
L + + AL L+ + LE K D+ ++ E +Q ++ + +
Sbjct: 2384 AQALCEDLSALVKEEYLKAELSRQ-LEGILKSFKDVEQKAENHVQHLQSACASS----HQ 2438
Query: 2162 FEQNASTFLQWILETRAYFLDGS--LLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDL 2219
F+Q + F W L+T+ + S + + LES ++ +K K + A K +
Sbjct: 2439 FQQMSRDFQAW-LDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE 2497
Query: 2220 GDNL------EDALILDIKYSTIGLAQQWD----QLYQLGLRMQHNLEQQIQAKD 2264
G+NL + L ++ +TI WD Q+ + +++ +LE+ ++ K+
Sbjct: 2498 GENLLLKTQGSEKAALQLQLNTI--KTNWDTFNKQVKERENKLKESLEKALKYKE 2550
Score = 41.2 bits (95), Expect = 0.012
Identities = 42/210 (20%), Positives = 92/210 (43%), Gaps = 23/210 (10%)
Query: 574 RRRLLKESLLLQKLYEDS------DDLKNWINKKKKLADDEDY-KDIQNLKSRVQKQQ-- 624
R+ LLK SLL Q L E+ DL NW+++ + D ++ D+ +++S ++ +
Sbjct: 259 RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNV 318
Query: 625 ---VFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGT 681
+ E E ++ + ++ IQ T + YA +L + S + +LL ++ +
Sbjct: 319 HRAIEEFESSLKEAKISEIQMTAPLKLT---YAE-----KLHRLESQYAKLLNTSRNQER 370
Query: 682 QLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQD 741
L + F + A + WL + E + + D+ + + + H L + +++
Sbjct: 371 HLDTLH---NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 427
Query: 742 QVDILTDLAAYFEEIGHPDSKDIRARQESL 771
+ + ++A HP I A + ++
Sbjct: 428 NIKSVQEIAEQLLLENHPARLTIEAYRAAM 457
Score = 40.8 bits (94), Expect = 0.016
Identities = 60/342 (17%), Positives = 134/342 (39%), Gaps = 53/342 (15%)
Query: 1707 EKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHE 1766
+ L E +F QDL +W++E +++ ++G DL V++ L+ HK + + E
Sbjct: 270 QNLTEEEINMKFVQDL---LNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFE 326
Query: 1767 PAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKL------EESLE 1820
+++ K+ EIQ+ + + EKL L L E L+
Sbjct: 327 SSLKEA-----KI--------SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLD 373
Query: 1821 YL-QFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVC 1879
L F+ A E W+NEK + E + D++ T +
Sbjct: 374 TLHNFVSRATNELIWLNEK---------------------EEEEVAYDWSERNTNIARKK 412
Query: 1880 AQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADV 1939
+++ ++ Q+E K + E L + I A++ ++ +++
Sbjct: 413 DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSW--ILQLCQC 470
Query: 1940 VEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQ 1999
VE I + + + + D+L ++ DA + + +R I L+D + +
Sbjct: 471 VEQHIKENTAYFEFFNDAKEATDYL-----RNLKDAIQRKYSCDRSSSIHKLEDLVQESM 525
Query: 2000 HNQSKAIEER--YAALLKRWEQLLEASAVHRQKLLEKQLPLQ 2039
+ + ++ + A L+ + + +++ + L+ +P++
Sbjct: 526 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIK 567
>gi|12025678 actinin, alpha 4 [Homo sapiens]
Length = 911
Score = 214 bits (545), Expect = 8e-55
Identities = 133/504 (26%), Positives = 253/504 (50%), Gaps = 20/504 (3%)
Query: 1927 DYAFQEFNWKADVVEAWIADKETSLKTNG-NGADLGDFLTLLAKQDTLDASLQSFQQERL 1985
D+ ++F KA + EAW KE LK A L D L+ K + ++ L + Q+R+
Sbjct: 412 DHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAA-HQDRV 470
Query: 1986 PEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLF 2045
+I + +L + S + R + +W+ L + R+ L + + L+ + L
Sbjct: 471 EQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLH 530
Query: 2046 VEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLEL 2105
+E+A +A+ NNW E E+L + ++ EI L H+ F ++L A + + +L +
Sbjct: 531 LEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAI 590
Query: 2106 DQQIKALGVP-------SSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEM 2158
++ + + S+PYT +T +++ W+ + ++ +R+ L +E+++Q N +
Sbjct: 591 HKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHL 650
Query: 2159 CQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218
++F A+ WI +T+ + ++ GTLE QL K+ ++ I K L +
Sbjct: 651 RRQFASQANVVGPWI-QTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQ 709
Query: 2219 LGDNLEDALILDIKYSTIGLAQ---QWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKE 2275
+++ALI D K++ + W+QL R + +E QI +D KG+S+E ++E
Sbjct: 710 QHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQE 769
Query: 2276 FSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEED-EHEPKFEKFLDAVDPGRKGYV 2334
F + HFD++ G L +EF++CL L Y VE D + E +F + + VDP G V
Sbjct: 770 FRASFNHFDKDHGGALGPEEFKACLISLGY---DVENDRQGEAEFNRIMSLVDPNHSGLV 826
Query: 2335 SLEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQ 2394
+ + + F+ +E+ + ++D++ +F+ LA K++IT E++++ L P+Q +C M
Sbjct: 827 TFQAFIDFM-SRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAP 885
Query: 2395 YMDPRGRSHLSGYDYVGFTNSYFG 2418
Y P DY F+ + +G
Sbjct: 886 YQGPDAVP--GALDYKSFSTALYG 907
Score = 68.6 bits (166), Expect = 7e-11
Identities = 73/345 (21%), Positives = 140/345 (40%), Gaps = 53/345 (15%)
Query: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAE-NTGVELDDV 1113
Q+ E N+ +L + L++ Y + A D+LEWI+ V +
Sbjct: 272 QKAETAANRICKVL-AVNQENEHLMEDYEKL-----ASDLLEWIRRTIPWLEDRVPQKTI 325
Query: 1114 WELQKKFDEFQK------------------DLNTNEPRLRDINKVADDLLFEGLLTPEGA 1155
E+Q+K ++F+ + NT + +LR N+ A P
Sbjct: 326 QEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPA--------FMPSEG 377
Query: 1156 QIRQELNSRWGSLQR--------LADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALS 1207
++ ++N+ W L++ L +E R+L H E F ++A + + K L
Sbjct: 378 KMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK 437
Query: 1208 AAD-PGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKME 1266
D + L ++AL R+HE FE DL D+V + A+ L+E + ++ + +
Sbjct: 438 HRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQK 497
Query: 1267 LNEAWEDLQGRTKDRKESLNEAQK--------FYLFLSKARDLQNWISSIGGMVSSQELA 1318
+ + W+ L T R+E+L + +K + +A NW+ S + +
Sbjct: 498 ICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIV 557
Query: 1319 EDLTGIEILLERHQEHRA---DMEAEAPTFQALEDFSAELIDSGH 1360
+ IE L+ H + ++ D + E A+ + + +S H
Sbjct: 558 HTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNH 602
Score = 62.0 bits (149), Expect = 7e-09
Identities = 38/172 (22%), Positives = 77/172 (44%), Gaps = 10/172 (5%)
Query: 575 RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD--IQNLKSRVQKQQVFEKELAV 632
RRL + L +K + + + W + K+ + DY+ + ++K+ ++K + FE +LA
Sbjct: 406 RRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAA 465
Query: 633 NKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQ--- 689
++ ++E I QE+ E +Y S NV TR ++ W+ L T + L + +Q
Sbjct: 466 HQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEA 525
Query: 690 -----LQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAV 736
L++ A W+E + + E++ + H +S +
Sbjct: 526 IDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTL 577
Score = 59.7 bits (143), Expect = 3e-08
Identities = 82/444 (18%), Positives = 172/444 (38%), Gaps = 55/444 (12%)
Query: 273 VTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELC-------A 325
+ I W++++ P T ++ + L HK KV+E C
Sbjct: 309 IRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHK---------PPKVQEKCQLEINFNT 359
Query: 326 KAEKLTLSH-PSDAPQIQEMKEDLVSSWEHIRALATSRYEKL--------QATYWYHRFS 376
KL LS+ P+ P +M D+ + W+H+ E L + + +F
Sbjct: 360 LQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFR 419
Query: 377 SDFDELSGWMNEKTAAINADELPTDVAGG-EVLLDRHQQHKHEIDSYDDRFQSADETGQD 435
W + K A + + T + L+ +H+ + ++ ++ DR + Q+
Sbjct: 420 QKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQE 479
Query: 436 LVNANHEASDEVREKMEILDNNWTALLELWDER-------HRQYEQCLDFHLFY-RDSEQ 487
L ++ S V + + + + W AL L R +Q E HL Y + +
Sbjct: 480 LNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAP 539
Query: 488 VDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAF---TAQEEKIITVDKTA----- 539
++WM L++ + +++ E L+ H+ F+ + E I+ + K A
Sbjct: 540 FNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAE 599
Query: 540 ---TKLIGDDHYDSENIKAIR------DGLLARRD-ALREKAATRRRLLKESLLLQKLYE 589
KL G + Y + + I L+ +RD AL E+ + ++ L ++
Sbjct: 600 SNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQ---SNEHLRRQFAS 656
Query: 590 DSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIE 649
++ + WI K + + L+ ++ + +E+ + K L+ +++ Q + E
Sbjct: 657 QANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQE 716
Query: 650 GGHYASDNVTTRLSEVASLWEELL 673
+ + + + + WE+LL
Sbjct: 717 ALIFDNKHTNYTMEHIRVGWEQLL 740
Score = 58.9 bits (141), Expect = 6e-08
Identities = 75/347 (21%), Positives = 146/347 (42%), Gaps = 44/347 (12%)
Query: 489 DSWMSRQEAFLENEDLGNS-LGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDH 547
++W +EA L++ D + L +AL++KHE FE A ++++ + A +L D+
Sbjct: 426 EAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDY 485
Query: 548 YDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDL-----------KN 596
YDS N+ + + DAL +RR L+++ +K E D L N
Sbjct: 486 YDSHNVNTRCQKICDQWDALGSLTHSRREALEKT---EKQLEAIDQLHLEYAKRAAPFNN 542
Query: 597 WI-NKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLE---NIQKTGQEMIEGGH 652
W+ + + L D I+ ++ + F+ L + E I K Q + E H
Sbjct: 543 WMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNH 602
Query: 653 Y---ASDNVTTRLSEVA-SLWEELLEATKQKGTQL------HEANQQL--QFENNAEDLQ 700
S+ TT ++ S WE++ + ++ L ++N+ L QF + A +
Sbjct: 603 IKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVG 662
Query: 701 RWLEDVEWQVTSEDYGKGLAE----VQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEI 756
W+ Q E+ G+ E ++++L E ++ + +D+L +E
Sbjct: 663 PWI-----QTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEA 717
Query: 757 GHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTE 803
D+K E + +E L +A + ++ + Q++ RD +
Sbjct: 718 LIFDNKHTNYTMEHIRVGWEQLLTTIA----RTINEVENQILTRDAK 760
Score = 55.8 bits (133), Expect = 5e-07
Identities = 68/343 (19%), Positives = 133/343 (38%), Gaps = 40/343 (11%)
Query: 161 QQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQ-VELVAKEGRVVE--- 216
+ Y + +D+LEWI +E + + + +K EDF+ V K +V E
Sbjct: 296 EDYEKLASDLLEWI---RRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQ 352
Query: 217 ----VNQYANECAEENHPDLPLIQSKQ-NEVNAAWERLRGLA----------LQRQKALS 261
N + N P + K +++N W+ L ++R + L
Sbjct: 353 LEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLD 412
Query: 262 NAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVAS-EGLFHSHKGLERNLAVMSDKV 320
+ A R K + EA W KE +L DY ++ + L H+ E +LA D+V
Sbjct: 413 HLAEKFRQKASIHEA--WTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRV 470
Query: 321 KELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQAT--------YWY 372
+++ A A++L D+ + + + W+ + +L SR E L+ T +
Sbjct: 471 EQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLH 530
Query: 373 HRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYD---DRFQSA 429
++ + WM + + + E L+ H Q K + D + +
Sbjct: 531 LEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAI 590
Query: 430 DETGQDLVNANH----EASDEVREKMEILDNNWTALLELWDER 468
+ Q + +NH ++ +I+++ W + +L +R
Sbjct: 591 HKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKR 633
Score = 53.5 bits (127), Expect = 2e-06
Identities = 57/273 (20%), Positives = 113/273 (41%), Gaps = 34/273 (12%)
Query: 1717 QFFQDLDDEESWIEEKLIRVSSQDYGR-DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775
+F Q E+W + K + +DY L ++ L++KH+ E +L AH+ ++ + +
Sbjct: 417 KFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAI 476
Query: 1776 AEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWI 1835
A++L + + R + + W+ L L +R LE++ + L+ + E A
Sbjct: 477 AQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYA-- 534
Query: 1836 NEKNALAVRGDCGDTLAATQSLLMKH--EALENDFAVHE---TRVQNVCAQGEDIL--NK 1888
K A + Q + + H E +E + H+ + + + + E IL +K
Sbjct: 535 --KRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHK 592
Query: 1889 VLQEESQNKE----------------ISSKIEALNEKTPSLAKA-IAAWKLQLEDDYAFQ 1931
Q +++ I+SK E + + P A + Q +++ +
Sbjct: 593 EAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRR 652
Query: 1932 EFNWKADVVEAWIADK-----ETSLKTNGNGAD 1959
+F +A+VV WI K S++ NG D
Sbjct: 653 QFASQANVVGPWIQTKMEEIGRISIEMNGTLED 685
Score = 46.2 bits (108), Expect = 4e-04
Identities = 66/302 (21%), Positives = 124/302 (41%), Gaps = 33/302 (10%)
Query: 1985 LPEITDLKDKLISAQHNQSKAIEERYAALLKRWE--QLLEASAVHRQKLLEKQLPLQKAE 2042
+P++ D +D +++ KAI ++ + Q E +A K+L Q+ E
Sbjct: 237 IPKMLDAED-IVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVN---QENE 292
Query: 2043 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCL 2102
L ++ AS L W + L + V ++ E++Q +D D+ + KC
Sbjct: 293 HLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQ 352
Query: 2103 LE-----LDQQIKALGVPS-SPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNF 2156
LE L +++ P+ P V + W+HL + E+ L E R +
Sbjct: 353 LEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLD 412
Query: 2157 EMCQEFEQNASTFLQWI-----------LETRAYFLDGSLLKETGTLESQLEANKRKQKE 2205
+ ++F Q AS W ET +L+++ ES L A++ + ++
Sbjct: 413 HLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQ 472
Query: 2206 IQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNL---EQQIQA 2262
I A+ ++L ++ D D+ ++ + QWD L L + L E+Q++A
Sbjct: 473 IAAIAQELNEL-DYYDS------HNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEA 525
Query: 2263 KD 2264
D
Sbjct: 526 ID 527
Score = 44.3 bits (103), Expect = 0.001
Identities = 25/102 (24%), Positives = 51/102 (50%), Gaps = 4/102 (3%)
Query: 1386 KRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDD--KSSLDSLEALMKKRDDLDKAI 1443
+R + LD E F+ E+W +E L+ D ++L ++AL++K + + +
Sbjct: 406 RRLERLDHLAE--KFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDL 463
Query: 1444 TAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKAL 1485
A + ++ + A+ L ++Y + TR Q++ D+W AL
Sbjct: 464 AAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDAL 505
Score = 31.6 bits (70), Expect = 9.9
Identities = 78/378 (20%), Positives = 138/378 (36%), Gaps = 65/378 (17%)
Query: 738 ARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQL 797
AR D+ I+T +++++ + A + V E L +KL L L+
Sbjct: 250 ARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDL-LEW 308
Query: 798 ICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQE------ 851
I R W+++ P T + + L + H+ P++QE
Sbjct: 309 IRRTIP----WLEDRVPQKTIQEMQQKLEDFRDYRRVHK---------PPKVQEKCQLEI 355
Query: 852 ----------ITERGNKMVEEGHFAAE--DVASRVKSLNQNMESLRARAARRQNDLEANV 899
++ R M EG ++ + ++ + E RR L+
Sbjct: 356 NFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLA 415
Query: 900 QFQQYLADLHEAETWIREKEPIVDNTNYG-ADEEAAGALLKKHEAFLLDLNSFGDSMKAL 958
+ + A +HEA W KE ++ + +Y A AL++KHEAF DL
Sbjct: 416 EKFRQKASIHEA--WTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDL---------- 463
Query: 959 RNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPR-EVTMKKGDVLTLLS-----SINK 1012
A Q + + +A E + YD + R + + D L L+ ++ K
Sbjct: 464 -----AAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEK 518
Query: 1013 DWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIE------NQYRS 1066
++EA D + Y +R A M + I E+IE +Q++S
Sbjct: 519 TEKQLEAIDQ---LHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKS 575
Query: 1067 LLDRAEERRRRLLQRYNE 1084
L A+ R +L + E
Sbjct: 576 TLPDADREREAILAIHKE 593
>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
Length = 914
Score = 213 bits (542), Expect = 2e-54
Identities = 138/523 (26%), Positives = 257/523 (49%), Gaps = 36/523 (6%)
Query: 1927 DYAFQEFNWKADVVEAWIADKETSLKTNG-NGADLGDFLTLLAKQDTLDASLQSFQQERL 1985
D+ ++F KA + EAW KE L+ A L + LL K + ++ L + Q+R+
Sbjct: 393 DHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA-HQDRV 451
Query: 1986 PEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLF 2045
+I + +L + S ++ R + +W+ L + R+ L + L+ + L+
Sbjct: 452 EQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLY 511
Query: 2046 VEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLEL 2105
+E+A +A+ NNW E E+L + ++ EI+ L HE F A+L A + +L +
Sbjct: 512 LEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGI 571
Query: 2106 DQQIKAL-------GVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEM 2158
++ + ++PYT +T + + W H+ ++ R+Q L +E ARQ N +
Sbjct: 572 HNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERL 631
Query: 2159 CQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218
++F A+ WI +T+ + ++ GTLE QL ++ +K I K ++ ++
Sbjct: 632 RKQFGAQANVIGPWI-QTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEG 690
Query: 2219 LGDNLEDALILDIK---YSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKE 2275
+++ALI D K Y+ + W+QL R + +E QI +D KG+S+E + E
Sbjct: 691 DHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNE 750
Query: 2276 FSTIYKHFDENLTGRLTHKEFRSCLRGLNYYL--------PMVEEDEH------------ 2315
F + HFD + +G L +EF++CL L Y + M++ D+
Sbjct: 751 FRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMG 810
Query: 2316 EPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKED 2375
E +F + + VDP R G V+ + + F+ +E+ + ++D++ +F+ LA K+YIT ++
Sbjct: 811 EAEFARIMSIVDPNRLGVVTFQAFIDFM-SRETADTDTADQVMASFKILAGDKNYITMDE 869
Query: 2376 MKQALTPEQVSFCATHMQQYMDPRGRSHLSGYDYVGFTNSYFG 2418
+++ L P+Q +C M Y P S DY+ F+ + +G
Sbjct: 870 LRRELPPDQAEYCIARMAPYTGP--DSVPGALDYMSFSTALYG 910
Score = 68.2 bits (165), Expect = 1e-10
Identities = 97/489 (19%), Positives = 193/489 (39%), Gaps = 84/489 (17%)
Query: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWI-------QEKKAENTG 1107
Q+ E N+ +L + +L++ Y + A D+LEWI + + ENT
Sbjct: 253 QKAETAANRICKVL-AVNQENEQLMEDYEKL-----ASDLLEWIRRTIPWLENRVPENT- 305
Query: 1108 VELDDVWELQKKFDEFQK------------------DLNTNEPRLRDINKVADDLLFEGL 1149
+ +Q+K ++F+ + NT + +LR N+ A
Sbjct: 306 -----MHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPA-------- 352
Query: 1150 LTPEGAQIRQELNSRWGSLQR--------LADEQRQLLGSAHAVEVFHREADDTKEQIEK 1201
P ++ ++N+ WG L++ L +E R+L H E F ++A + +
Sbjct: 353 FMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDG 412
Query: 1202 KCQALSAAD-PGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDL 1260
K L D + L ++AL ++HE FE DL D+V + A+ L+E + +
Sbjct: 413 KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSV 472
Query: 1261 QRQKMELNEAWEDLQGRTKDRKESLNEAQK-------FYL-FLSKARDLQNWISSIGGMV 1312
+ ++ + W++L T+ R+E+L +K YL + +A NW+ +
Sbjct: 473 NARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDL 532
Query: 1313 SSQELAEDLTGIEILLERHQEHRA---DMEAEAPTFQALEDFSAELIDSGH----HASPE 1365
+ + I+ L H++ +A D + E + + ++++ + H +P
Sbjct: 533 QDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPY 592
Query: 1366 IEKKLQAVKLERDDLEKAWEKRKKILDQCLELQ--------MFQGNCDQVESWMVARENS 1417
Q + + D + + +R + L + Q F + + W+ +
Sbjct: 593 TTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEE 652
Query: 1418 LRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEH----FAESLIADE---HYAKEE 1470
+ +LE + +K+I + KI LE E+LI D +Y E
Sbjct: 653 IGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEH 712
Query: 1471 IATRLQRVL 1479
I +++L
Sbjct: 713 IRVGWEQLL 721
Score = 57.0 bits (136), Expect = 2e-07
Identities = 54/234 (23%), Positives = 95/234 (40%), Gaps = 35/234 (14%)
Query: 161 QQYVQECADILEWI-------------GDKEAIATSVELGEDWERTEVLHKKFEDFQVEL 207
+ Y + +D+LEWI A+ +E D+ R K E Q+E
Sbjct: 277 EDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLE- 335
Query: 208 VAKEGRVVEVNQYANECAEENHPD-LPLIQSKQNEVNAAWERLRGLA----------LQR 256
+ N + N P +P +++N AW L + ++R
Sbjct: 336 -------INFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388
Query: 257 QKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVAS-EGLFHSHKGLERNLAV 315
+ L + A R K + EA W KE +L +DY ++ + L H+ E +LA
Sbjct: 389 LERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446
Query: 316 MSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQAT 369
D+V+++ A A++L D+P + + + W+++ AL R E L+ T
Sbjct: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
Score = 54.7 bits (130), Expect = 1e-06
Identities = 32/140 (22%), Positives = 66/140 (47%), Gaps = 10/140 (7%)
Query: 575 RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD--IQNLKSRVQKQQVFEKELAV 632
RRL + L +K + + + W + K+ + +DY+ + +K+ ++K + FE +LA
Sbjct: 387 RRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446
Query: 633 NKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQ---- 688
++ ++E I QE+ E +Y S +V R ++ W+ L T+++ L +
Sbjct: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506
Query: 689 ----QLQFENNAEDLQRWLE 704
L++ A W+E
Sbjct: 507 IDQLYLEYAKRAAPFNNWME 526
Score = 52.8 bits (125), Expect = 4e-06
Identities = 46/186 (24%), Positives = 85/186 (45%), Gaps = 6/186 (3%)
Query: 608 EDYKDIQNLKSRVQKQQVFEKELAVNKTQLE-NIQKTGQEMIEGGHYASD--NVTTRLSE 664
ED++D + L + Q+ + E+ N Q + + M G SD N L +
Sbjct: 314 EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQ 373
Query: 665 VASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKG-LAEVQ 723
V +EE L ++ +L ++ F A + W + E + +DY L+E++
Sbjct: 374 VEKGYEEWLLNEIRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLRQKDYETATLSEIK 431
Query: 724 NRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLA 783
L+KH ES +AA QD+V+ + +A E+ + DS + AR + + +++ L
Sbjct: 432 ALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ 491
Query: 784 TRKKKL 789
R++ L
Sbjct: 492 KRREAL 497
Score = 52.0 bits (123), Expect = 7e-06
Identities = 51/254 (20%), Positives = 104/254 (40%), Gaps = 25/254 (9%)
Query: 1717 QFFQDLDDEESWIEEKLIRVSSQDYGR-DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775
+F Q E+W + K + +DY L ++ LLKKH+ E +L AH+ ++ + +
Sbjct: 398 KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAI 457
Query: 1776 AEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLE--------YLQFMQN 1827
A++L + + R + + W+ L L + R LE + + YL++ +
Sbjct: 458 AQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKR 517
Query: 1828 AEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQG-EDIL 1886
A W+ T+ Q L HE + + + + + G + +
Sbjct: 518 AAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK--ATLPDADKERLAILGIHNEV 575
Query: 1887 NKVLQEESQN------------KEISSKIEALNEKTPSLAKAIA-AWKLQLEDDYAFQEF 1933
+K++Q N +EI+ K + + + P +A+ Q ++ ++F
Sbjct: 576 SKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQF 635
Query: 1934 NWKADVVEAWIADK 1947
+A+V+ WI K
Sbjct: 636 GAQANVIGPWIQTK 649
Score = 52.0 bits (123), Expect = 7e-06
Identities = 60/277 (21%), Positives = 112/277 (40%), Gaps = 42/277 (15%)
Query: 489 DSWMSRQEAFLENEDLGNS-LGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDH 547
++W +EA L +D + L +ALL+KHE FE A ++++ + A +L D+
Sbjct: 407 EAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDY 466
Query: 548 YDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDL-----------KN 596
YDS ++ A + + D L RR L+ + +KL E D L N
Sbjct: 467 YDSPSVNARCQKICDQWDNLGALTQKRREALERT---EKLLETIDQLYLEYAKRAAPFNN 523
Query: 597 WINKKKKLADD----EDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGH 652
W+ + D ++IQ L + ++ + + + + I ++++ H
Sbjct: 524 WMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH 583
Query: 653 --YASDNVTTRLS--EVASLWEELLE--------ATKQKGTQLHEANQQLQFENNAEDLQ 700
A N T ++ E+ W+ + + T++ Q H + QF A +
Sbjct: 584 VNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIG 643
Query: 701 RWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVA 737
W+ Q E+ G+ E+ HG LE ++
Sbjct: 644 PWI-----QTKMEEIGRISIEM------HGTLEDQLS 669
Score = 48.1 bits (113), Expect = 1e-04
Identities = 47/265 (17%), Positives = 109/265 (41%), Gaps = 29/265 (10%)
Query: 1378 DDLEKAWE-------KRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDD--KSSLDS 1428
+ +EK +E +R + LD E F+ E+W +E LR D ++L
Sbjct: 372 EQVEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSE 429
Query: 1429 LEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKA- 1487
++AL+KK + + + A + ++ + A+ L ++Y + R Q++ D+W L A
Sbjct: 430 IKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGAL 489
Query: 1488 -----QLIDERTKLGDYANLKQFYRDLEE--------LEEWISEMLPTACDESYKDATNI 1534
+ ++ KL + Q Y + + +E + ++ T + ++ +
Sbjct: 490 TQKRREALERTEKL--LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGL 547
Query: 1535 QRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACD--GNEEAMKEQLEQLKEHWDHL 1592
+ + + + D + G+ N + +++ + G +++ WDH+
Sbjct: 548 TTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHV 607
Query: 1593 LERTNDKGKKLNEASRQQRFNTSIR 1617
+ + + L E +Q+ N +R
Sbjct: 608 RQLVPRRDQALTEEHARQQHNERLR 632
Score = 46.6 bits (109), Expect = 3e-04
Identities = 83/460 (18%), Positives = 173/460 (37%), Gaps = 56/460 (12%)
Query: 50 EDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTN-IQGKYQKHQSLEA-----EVQT 103
E+ ++ +++ A DL +WI + L ++ E+ + +Q K + + +VQ
Sbjct: 271 ENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQE 330
Query: 104 KSRLMSELEKTREERFTMGHSAHEETKAH-IEELRHLWDLLLELTLEKGDQLLRALKFQQ 162
K +L + + A ++ + ++ + W L ++ + LL ++ +
Sbjct: 331 KCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLE 390
Query: 163 YVQECADILE--------WIGDKEAIATSVELGEDWERT-----EVLHKKFEDFQVELVA 209
+ A+ W KEA+ +D+E + L KK E F+ +L A
Sbjct: 391 RLDHLAEKFRQKASIHEAWTDGKEAMLRQ----KDYETATLSEIKALLKKHEAFESDLAA 446
Query: 210 KEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANL--- 266
+ RV ++ A E E ++ D P + ++ ++ W+ L L +R++AL L
Sbjct: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506
Query: 267 -----QRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVK 321
+ + W++ L + +GL +H E+ A + D K
Sbjct: 507 IDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAH---EQFKATLPDADK 563
Query: 322 ELCA------KAEKLTLSH----PSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATY- 370
E A + K+ ++ P +++ W+H+R L R + L +
Sbjct: 564 ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHA 623
Query: 371 -------WYHRFSSDFDELSGWMNEKTAAINADELPTDVAGG-EVLLDRHQQHKHEIDSY 422
+F + + + W+ K I + ++ G E L +Q++ I +Y
Sbjct: 624 RQQHNERLRKQFGAQANVIGPWIQTKMEEIG--RISIEMHGTLEDQLSHLRQYEKSIVNY 681
Query: 423 DDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALL 462
+ + Q + A + ME + W LL
Sbjct: 682 KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
Score = 46.6 bits (109), Expect = 3e-04
Identities = 38/190 (20%), Positives = 82/190 (43%), Gaps = 11/190 (5%)
Query: 1582 LEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKD-QARDLA 1640
LEQ+++ ++ L + ++L+ + + R SI E W E +L KD + L+
Sbjct: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIH--EAWTDGKEAMLRQKDYETATLS 428
Query: 1641 SAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQE 1700
LLKKH+ E ++ A +D ++ + +A++L ++ + + + ++ N+
Sbjct: 429 EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGA 488
Query: 1701 LAAAHHEKLKEAYALFQFFQDLDDE--------ESWIEEKLIRVSSQDYGRDLQGVQNLL 1752
L E L+ L + L E +W+E + + ++ +Q L
Sbjct: 489 LTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLT 548
Query: 1753 KKHKRLEGEL 1762
H++ + L
Sbjct: 549 TAHEQFKATL 558
Score = 45.4 bits (106), Expect = 7e-04
Identities = 78/455 (17%), Positives = 178/455 (39%), Gaps = 48/455 (10%)
Query: 262 NAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVK 321
N ++ +++ ++ ++WI+ P L + + A + + R KV+
Sbjct: 272 NEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRR--LHKPPKVQ 329
Query: 322 ELC-------AKAEKLTLSH-PSDAPQIQEMKEDLVSSWEHIRALATSRYEKL------- 366
E C KL LS+ P+ P M D+ ++W + + E L
Sbjct: 330 EKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRL 389
Query: 367 -QATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGG-EVLLDRHQQHKHEIDSYDD 424
+ + +F W + K A + + T + LL +H+ + ++ ++ D
Sbjct: 390 ERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQD 449
Query: 425 RFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYE------QCLD- 477
R + Q+L ++ S V + + + + W L L +R E + +D
Sbjct: 450 RVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQ 509
Query: 478 FHLFY-RDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEK---II 533
+L Y + + ++WM L++ + +++ + L HE F+ +++ I+
Sbjct: 510 LYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAIL 569
Query: 534 TVDKTATKLI--------GDDHYDSENIKAIRD------GLLARRD-ALREKAATRRRLL 578
+ +K++ G + Y + + I L+ RRD AL E+ A ++
Sbjct: 570 GIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQH-- 627
Query: 579 KESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLE 638
L ++ ++ + WI K + + L+ ++ + +EK + K +++
Sbjct: 628 -NERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKID 686
Query: 639 NIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELL 673
++ Q + E + + + + + WE+LL
Sbjct: 687 QLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
Score = 43.1 bits (100), Expect = 0.003
Identities = 63/293 (21%), Positives = 118/293 (40%), Gaps = 30/293 (10%)
Query: 1985 LPEITDLKDKLISAQHNQSKAIEERYAALLKRWE--QLLEASAVHRQKLLEKQLPLQKAE 2042
+P++ D +D ++ KAI ++ + Q E +A K+L Q+ E
Sbjct: 218 IPKMLDAED-IVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVN---QENE 273
Query: 2043 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCL 2102
L ++ AS L W + L V +++ ++Q +D D+ + KC
Sbjct: 274 QLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQ 333
Query: 2103 LE-----LDQQIKALGVPS-SPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNF 2156
LE L +++ P+ P V + W L + + E+ L E R +
Sbjct: 334 LEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLD 393
Query: 2157 EMCQEFEQNASTFLQWI-----------LETRAYFLDGSLLKETGTLESQLEANKRKQKE 2205
+ ++F Q AS W ET +LLK+ ES L A++ + ++
Sbjct: 394 HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQ 453
Query: 2206 IQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQ 2258
I A+ ++L ++ + D+ ++ + I QWD L L + + LE+
Sbjct: 454 IAAIAQELNEL-----DYYDSPSVNARCQKI--CDQWDNLGALTQKRREALER 499
Score = 33.5 bits (75), Expect = 2.6
Identities = 52/240 (21%), Positives = 91/240 (37%), Gaps = 35/240 (14%)
Query: 738 ARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQL 797
AR D+ I+T +++++ + A + V E L +KL L L+
Sbjct: 231 ARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDL-LEW 289
Query: 798 ICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQE------ 851
I R W++ P T + + L + H+ P++QE
Sbjct: 290 IRRTIP----WLENRVPENTMHAMQQKLEDFRDYRRLHK---------PPKVQEKCQLEI 336
Query: 852 ----------ITERGNKMVEEGHFAAE--DVASRVKSLNQNMESLRARAARRQNDLEANV 899
++ R M EG ++ + ++ + + E RR L+
Sbjct: 337 NFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLA 396
Query: 900 QFQQYLADLHEAETWIREKEPIVDNTNYG-ADEEAAGALLKKHEAFLLDLNSFGDSMKAL 958
+ + A +HEA W KE ++ +Y A ALLKKHEAF DL + D ++ +
Sbjct: 397 EKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
>gi|4501893 actinin, alpha 2 [Homo sapiens]
Length = 894
Score = 206 bits (525), Expect = 2e-52
Identities = 132/503 (26%), Positives = 252/503 (50%), Gaps = 23/503 (4%)
Query: 1927 DYAFQEFNWKADVVEAWIADKETSL-KTNGNGADLGDFLTLLAKQDTLDASLQSFQQERL 1985
++ ++F KA E W KE L + + A L + LL K + ++ L + Q+R+
Sbjct: 400 EHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAA-HQDRV 458
Query: 1986 PEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLF 2045
+I + +L ++ + + +R + +W++L + R+ L + L+ + L
Sbjct: 459 EQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLH 518
Query: 2046 VEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLL-- 2103
+EFA +A+ NNW E E+L + S+ EI+ L HE F A+L A + + ++
Sbjct: 519 LEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAI 578
Query: 2104 --ELDQQIKALGV---PSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEM 2158
E+++ I++ + S+PY+ +T++ L W + ++ R+Q LQ+E ARQ N +
Sbjct: 579 QNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERL 638
Query: 2159 CQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218
++F A+ WI + + + S ++ TG LE Q+ K+ + I K + K+
Sbjct: 639 RRQFAAQANAIGPWI-QNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEG 697
Query: 2219 LGDNLEDALILDIK---YSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKE 2275
+++AL+ D K Y+ + W+ L R + +E QI +D KG+++E + E
Sbjct: 698 DHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNE 757
Query: 2276 FSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVS 2335
F + HFD G + H++FR+CL + Y D E +F + + VDP +G V+
Sbjct: 758 FRASFNHFDRRKNGLMDHEDFRACLISMGY-------DLGEAEFARIMTLVDPNGQGTVT 810
Query: 2336 LEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQY 2395
+ + F+ +E+ + +++++ +F+ LA K YI E++++ L P+Q +C M Y
Sbjct: 811 FQSFIDFM-TRETADTDTAEQVIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPAY 869
Query: 2396 MDPRGRSHLSGYDYVGFTNSYFG 2418
P S DY F+++ +G
Sbjct: 870 SGP--GSVPGALDYAAFSSALYG 890
Score = 75.5 bits (184), Expect = 6e-13
Identities = 94/446 (21%), Positives = 183/446 (41%), Gaps = 63/446 (14%)
Query: 1073 ERRRRLLQRYNEFLLAYEAGDMLEWIQ-----------EKKAENTGVELDDVWELQKKFD 1121
+ RL++ Y A ++LEWI+ EK + +L+D + ++K
Sbjct: 277 QENERLMEEYERL-----ASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK 331
Query: 1122 --------EFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELN-SRWGSLQRLA 1172
+ + + NT + +LR N+ A + EG + + A Q L + G + L
Sbjct: 332 PPKVQEKCQLEINFNTLQTKLRISNRPAF-MPSEGKMVSDIAGAWQRLEQAEKGYEEWLL 390
Query: 1173 DEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAAD-PGSDLFSVQALQRRHEGFERD 1231
+E R+L H E F ++A + K Q L D + L V+AL R+HE FE D
Sbjct: 391 NEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESD 450
Query: 1232 LVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKF 1291
L D+V + A+ L+E ++ + ++ + W+ L T+ R+E+L +K
Sbjct: 451 LAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKL 510
Query: 1292 --------YLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRA---DMEA 1340
F +A NW+ + + + I+ L+ H++ +A + +
Sbjct: 511 LETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADG 570
Query: 1341 EAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKIL---DQCLEL 1397
E + A+++ ++I S + I + D+L W+K K+++ DQ L+
Sbjct: 571 ERQSIMAIQNEVEKVIQS---YNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQE 627
Query: 1398 QM------------FQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITA 1445
++ F + + W+ +N + +SS+ AL +D +
Sbjct: 628 ELARQHANERLRRQFAAQANAIGPWI---QNKMEEIARSSIQITGAL----EDQMNQLKQ 680
Query: 1446 QEGKITDLEHFAESLIADEHYAKEEI 1471
E I + ++ + L D +E +
Sbjct: 681 YEHNIINYKNNIDKLEGDHQLIQEAL 706
Score = 60.1 bits (144), Expect = 3e-08
Identities = 53/258 (20%), Positives = 114/258 (44%), Gaps = 17/258 (6%)
Query: 2017 WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEE-NLSEPVHCVSL 2075
W++L +A + + LL + L++ E L +F KAS W E+ L + SL
Sbjct: 375 WQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASL 434
Query: 2076 NEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLS 2135
E+R L + HE F + LA Q + + + Q++ L + + + W L
Sbjct: 435 TEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLG 494
Query: 2136 DIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQ 2195
+ ++R + L++ E ++ EF + A+ F W+ D ++ ++S
Sbjct: 495 TLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSL 554
Query: 2196 LEANKR----------KQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTI---GLAQQW 2242
+ A+++ +++ I A++ ++ K++ + + YST+ L +W
Sbjct: 555 ITAHEQFKATLPEADGERQSIMAIQNEVEKVI---QSYNIRISSSNPYSTVTMDELRTKW 611
Query: 2243 DQLYQLGLRMQHNLEQQI 2260
D++ QL +L++++
Sbjct: 612 DKVKQLVPIRDQSLQEEL 629
Score = 57.8 bits (138), Expect = 1e-07
Identities = 81/458 (17%), Positives = 176/458 (38%), Gaps = 54/458 (11%)
Query: 262 NAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVK 321
N ++ ++R +E ++WI+ P L + K + A + + R KV+
Sbjct: 279 NERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK--PPKVQ 336
Query: 322 ELC-------AKAEKLTLSH-PSDAPQIQEMKEDLVSSWEHIRALATS----------RY 363
E C KL +S+ P+ P +M D+ +W+ + R
Sbjct: 337 EKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRL 396
Query: 364 EKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYD 423
E+L+ R + E + E+ + D + LL +H+ + ++ ++
Sbjct: 397 ERLEHLAEKFRQKASTHETWAYGKEQIL-LQKDYESASLTEVRALLRKHEAFESDLAAHQ 455
Query: 424 DRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYE------QCLD 477
DR + Q+L ++ + V ++ + + + W L L +R E + +D
Sbjct: 456 DRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETID 515
Query: 478 -FHL-FYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAF---TAQEEKI 532
HL F + + ++WM L++ + +S+ ++L+ HE F+ + + I
Sbjct: 516 QLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSI 575
Query: 533 ITVDKTATKLIGDDHYDSENIK---------AIRDGLLARRDALREKAATRRRLLKESLL 583
+ + K+I S NI+ D L + D +++ R + L+E L
Sbjct: 576 MAIQNEVEKVI-----QSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELA 630
Query: 584 LQKLYE--------DSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKT 635
Q E ++ + WI K + + L+ ++ + + +E + K
Sbjct: 631 RQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKN 690
Query: 636 QLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELL 673
++ ++ Q + E + + + + + WE LL
Sbjct: 691 NIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLL 728
Score = 57.8 bits (138), Expect = 1e-07
Identities = 60/294 (20%), Positives = 113/294 (38%), Gaps = 29/294 (9%)
Query: 161 QQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQ--------VELVAKEG 212
++Y + +++LEWI +E + + + KK EDF+ ++ K
Sbjct: 284 EEYERLASELLEWI---RRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQ 340
Query: 213 RVVEVNQYANECAEENHPDLPLIQSKQ-NEVNAAWERLRGLALQRQKALSNAAN------ 265
+ N + N P + K +++ AW+RL ++ L N
Sbjct: 341 LEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLE 400
Query: 266 --LQRFKRDVTEAIQWIKEKEPVLTSEDY-GKDLVASEGLFHSHKGLERNLAVMSDKVKE 322
++F++ + W KE +L +DY L L H+ E +LA D+V++
Sbjct: 401 HLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQ 460
Query: 323 LCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRAL------ATSRYEKLQAT--YWYHR 374
+ A A++L DA + + + + W+ + L A R EKL T +
Sbjct: 461 IAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLE 520
Query: 375 FSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQS 428
F+ + WM + + + + L+ H+Q K + D QS
Sbjct: 521 FAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQS 574
Score = 54.3 bits (129), Expect = 1e-06
Identities = 55/218 (25%), Positives = 96/218 (44%), Gaps = 28/218 (12%)
Query: 601 KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTT 660
+KKL D DY+ ++ +VQ++ E +T+L + EG
Sbjct: 317 QKKLEDFRDYRR-KHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEG---------K 366
Query: 661 RLSEVASLWEELLEATKQKGTQLHEANQQLQ--------FENNAEDLQRWLEDVEWQVTS 712
+S++A W+ L +A K L ++L+ F A + W E +
Sbjct: 367 MVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQ 426
Query: 713 EDY-GKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESL 771
+DY L EV+ LRKH ES +AA QD+V+ + +A E+ + D+ ++ R + +
Sbjct: 427 KDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKI 486
Query: 772 VCRFEAL-------KEPLATRKKKL--LDLLHLQLICR 800
+++ L +E L +K L +D LHL+ R
Sbjct: 487 CDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKR 524
Score = 54.3 bits (129), Expect = 1e-06
Identities = 34/165 (20%), Positives = 74/165 (44%), Gaps = 10/165 (6%)
Query: 575 RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD--IQNLKSRVQKQQVFEKELAV 632
RRL + L +K + + + W K+++ +DY+ + +++ ++K + FE +LA
Sbjct: 394 RRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAA 453
Query: 633 NKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQ---- 688
++ ++E I QE+ E ++ + NV R ++ W+ L T+++ L +
Sbjct: 454 HQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLET 513
Query: 689 ----QLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729
L+F A W+E + + E+Q+ + H
Sbjct: 514 IDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAH 558
Score = 52.4 bits (124), Expect = 5e-06
Identities = 53/253 (20%), Positives = 106/253 (41%), Gaps = 23/253 (9%)
Query: 1717 QFFQDLDDEESWIEEKLIRVSSQDY-GRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775
+F Q E+W K + +DY L V+ LL+KH+ E +L AH+ ++ + +
Sbjct: 405 KFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAI 464
Query: 1776 AEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLE------ESLE--YLQFMQN 1827
A++L + + R + + W++L L + R LE E+++ +L+F +
Sbjct: 465 AQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKR 524
Query: 1828 AEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILN 1887
A W+ ++ QSL+ HE + + Q++ A ++
Sbjct: 525 AAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEV-E 583
Query: 1888 KVLQE-----ESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQ--------EFN 1934
KV+Q S N + ++ L K + + + L+++ A Q +F
Sbjct: 584 KVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFA 643
Query: 1935 WKADVVEAWIADK 1947
+A+ + WI +K
Sbjct: 644 AQANAIGPWIQNK 656
Score = 52.0 bits (123), Expect = 7e-06
Identities = 73/353 (20%), Positives = 150/353 (42%), Gaps = 40/353 (11%)
Query: 481 FYRDSEQVDSWMSRQEAFLENEDLGN-SLGSAEALLQKHEDFEEAFTAQEEKIITVDKTA 539
F + + ++W +E L +D + SL ALL+KHE FE A ++++ + A
Sbjct: 406 FRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIA 465
Query: 540 TKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDL----- 594
+L D++D+ N+ + + D L RR L+ ++KL E D L
Sbjct: 466 QELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALER---MEKLLETIDQLHLEFA 522
Query: 595 ------KNWI-NKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAV---NKTQLENIQKTG 644
NW+ + L D I+ ++S + + F+ L + + IQ
Sbjct: 523 KRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEV 582
Query: 645 QEMIEGGH--YASDN--VTTRLSEVASLWEELLEATKQKGTQLHE------ANQQL--QF 692
+++I+ + +S N T + E+ + W+++ + + L E AN++L QF
Sbjct: 583 EKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQF 642
Query: 693 ENNAEDLQRWLEDVEWQV--TSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLA 750
A + W+++ ++ +S L + N+L+++ E + ++ +D L
Sbjct: 643 AAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQY---EHNIINYKNNIDKLEGDH 699
Query: 751 AYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTE 803
+E D+K E + +E L +A + ++ + Q++ RD +
Sbjct: 700 QLIQEALVFDNKHTNYTMEHIRVGWELLLTTIA----RTINEVETQILTRDAK 748
Score = 45.8 bits (107), Expect = 5e-04
Identities = 64/334 (19%), Positives = 133/334 (39%), Gaps = 30/334 (8%)
Query: 2039 QKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQAD 2098
Q+ E L E+ AS L W + L ++ +++ +D D+ +
Sbjct: 277 QENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQ 336
Query: 2099 FKCLLE-----LDQQIKALGVPS-SPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQ 2152
KC LE L +++ P+ P V + W+ L + E+ L E R
Sbjct: 337 EKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRL 396
Query: 2153 VKNFEMCQEFEQNASTFLQWILETRAYFLD-----------GSLLKETGTLESQLEANKR 2201
+ + ++F Q AST W L +LL++ ES L A++
Sbjct: 397 ERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQD 456
Query: 2202 KQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQ 2261
+ ++I A+ ++L ++ + DA+ ++ + I QWD+L L + + LE+
Sbjct: 457 RVEQIAAIAQELNEL-----DYHDAVNVNDRCQKI--CDQWDRLGTLTQKRREALERM-- 507
Query: 2262 AKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEK 2321
+ + ++ EF+ F+ + G + + + + ++ E +F+
Sbjct: 508 -EKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHE---QFKA 563
Query: 2322 FLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSD 2355
L D R+ +++++ +I + I SS+
Sbjct: 564 TLPEADGERQSIMAIQNEVEKVIQSYNIRISSSN 597
Score = 38.1 bits (87), Expect = 0.11
Identities = 53/239 (22%), Positives = 90/239 (37%), Gaps = 35/239 (14%)
Query: 739 RQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLI 798
+ D+ I+T ++ ++ + + A + V E L ++L L L+ I
Sbjct: 239 KPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASEL-LEWI 297
Query: 799 CRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQE------- 851
R W++ P T + K L + +H+ P++QE
Sbjct: 298 RRTIP----WLENRTPEKTMQAMQKKLEDFRDYRRKHK---------PPKVQEKCQLEIN 344
Query: 852 ---------ITERGNKMVEEGHFAAEDVAS--RVKSLNQNMESLRARAARRQNDLEANVQ 900
I+ R M EG ++ + R++ + E RR LE +
Sbjct: 345 FNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAE 404
Query: 901 FQQYLADLHEAETWIREKEPIVDNTNY-GADEEAAGALLKKHEAFLLDLNSFGDSMKAL 958
+ A HE TW KE I+ +Y A ALL+KHEAF DL + D ++ +
Sbjct: 405 KFRQKASTHE--TWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQI 461
Score = 32.3 bits (72), Expect = 5.8
Identities = 42/177 (23%), Positives = 69/177 (38%), Gaps = 26/177 (14%)
Query: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY-E 82
+ ++R+E L R + E + D HL+ KR A W+ + L D
Sbjct: 496 LTQKRREALERMEKLLETI--------DQLHLEFAKRAAP-FNNWMEGAMEDLQDMFIVH 546
Query: 83 DPTNIQGKYQKHQSLEA-------EVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEE 135
IQ H+ +A E Q+ + +E+EK + S++ + ++E
Sbjct: 547 SIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDE 606
Query: 136 LRHLWDLLLELTLEKGDQLLRALKFQ--------QYVQECADILEWIGDK-EAIATS 183
LR WD + +L + L L Q Q+ + I WI +K E IA S
Sbjct: 607 LRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARS 663
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 191 bits (484), Expect = 1e-47
Identities = 444/2405 (18%), Positives = 942/2405 (39%), Gaps = 222/2405 (9%)
Query: 19 ETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIMEK---VN 74
+ AE ++ ++E+ +R++ E R ++LE+S HL F+ L W+MEK +
Sbjct: 2977 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMG 3036
Query: 75 ILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIE 134
+L S DP + + Q+ Q + E + + + +L + + T T +
Sbjct: 3037 VLGPLSI-DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQK 3095
Query: 135 ELRHLWDLLLELTLEKGDQ-------LLRALKFQQYVQECADILEWIGDK----EAIATS 183
EL+ + +ELT + + ++++ ++Q+ +Q+ ++ + +G + AI+T
Sbjct: 3096 ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQ 3155
Query: 184 VE-LGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEV 242
E + + E T + E E+ + E++ E ++ ++ + V
Sbjct: 3156 PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE-----LKKRLETV 3210
Query: 243 NAAWERLRGLALQRQKALSNA-ANLQRFKRDVTEAIQWIKEKEPVLTSE-DYGKDLVASE 300
+ L LA R L A A+ Q+F++ E W+ +K+ L +
Sbjct: 3211 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 3270
Query: 301 GLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHP--SDAPQIQEMKEDLVSSWEHIRAL 358
++ +++L S + + A+ E L LS P + +Q +L + WE +
Sbjct: 3271 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 3330
Query: 359 ATSRYEKLQ-ATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKH 417
R +L+ ++ ++L W+ + A ++ + D E L R + +
Sbjct: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 3390
Query: 418 EIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLD 477
E++ + + L+N++ D +R++ ++ N A+ E + E+
Sbjct: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQ 3450
Query: 478 -FHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVD 536
F + ++ + + LE D S + L+K +E A E ++ +
Sbjct: 3451 RLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLR 3510
Query: 537 KTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKN 596
L+ D S+ + + +A+++ L K + L+ + + ++
Sbjct: 3511 NFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE 3570
Query: 597 WINKKKKLADDEDY-----KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMI-EG 650
++ L D+ D +D +L+S+++ ++F ++ V K +E + + M+ E
Sbjct: 3571 MFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEE 3630
Query: 651 GHYASDNVTTRLSEVASLWEELLEATKQKGTQLH-------EANQQLQFENNAEDLQRWL 703
G + L + +L E K + QL + ++L+ N+A
Sbjct: 3631 GTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEA 3690
Query: 704 EDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHP---- 759
E ++W V +E E+ N+ L +++QVD L +G
Sbjct: 3691 EALQWVVGTE------VEIINQQ-----LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQS 3739
Query: 760 -----DSKDIRARQESLVCRFEALKEPLATRKKKLLD-LLHLQLICRDTEDEEAWIQETE 813
D + + E + R+ L + +A R +L + LLH E +W+ +TE
Sbjct: 3740 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3799
Query: 814 -------PSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFA 866
P + + K I +KLL R +L++ + + + G ++ + A
Sbjct: 3800 ELIANQKPPSAEYKVVKAQIQEQKLLQR---LLDD---RKATVDMLQAEGGRIAQSAELA 3853
Query: 867 -AEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIRE-----KEP 920
E + +++SL L ++AA RQ LE + + HE I + ++
Sbjct: 3854 DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAK---QFHETAEPISDFLSVTEKK 3910
Query: 921 IVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQ 980
+ ++ G + +H+A D+ + + + + +GV E+
Sbjct: 3911 LANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEK 3970
Query: 981 ----------------RVMALYDFQARSPREVTMKKGDVLTLLSSIN------------K 1012
R AL D + R + +VL L+ + +
Sbjct: 3971 IDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQ 4030
Query: 1013 DWWKVEAADHQGIVPAVYVRRLAHDEF-----PMLPQRRREEPGNITQRQEQIENQYRSL 1067
D + ADH + + R+ D+ +L Q EE I ++ + I+ +Y +
Sbjct: 4031 DVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADI 4090
Query: 1068 LDRAEERRRRLLQRYN---EFLLAYEAGDMLEWIQEKKAE--------NTGVELDDVWEL 1116
+ + R L Q +F YE ++ W++E + E TG ++ +
Sbjct: 4091 TVTSSKALRTLEQARQLATKFQSTYE--ELTGWLREVEEELATSGGQSPTGEQIPQFQQR 4148
Query: 1117 QKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQ-----IRQELNSRWGSLQRL 1171
QK E +K++ + L +N+V+ LL L P A+ + + N ++ +
Sbjct: 4149 QK---ELKKEVMEHRLVLDTVNEVSRALLE---LVPWRAREGLDKLVSDANEQYKLVSDT 4202
Query: 1172 ADEQRQLLGSAHAVEVFHREADDTK----EQIEKKCQALSAADPGSDLFSVQALQRRHEG 1227
++ + +A + +A D + + ++K AL D + Q ++
Sbjct: 4203 IGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK--A 4260
Query: 1228 FERDLVPLGDKVT-ILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLN 1286
F D++ D + + +E + LQ + L + +E + +R L
Sbjct: 4261 FSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLE 4320
Query: 1287 EAQKFY-LFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEA--- 1342
AQ F +L WI +++ +L E L ++ +E R E+ A
Sbjct: 4321 RAQVLVNQFWETYEELSPWIEETRALIA--QLPSPAIDHEQLRQQQEEMRQLRESIAEHK 4378
Query: 1343 PTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLE--LQMF 1400
P L +L + +E+K Q + +++ +R LD+ + Q+
Sbjct: 4379 PHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQIT 4438
Query: 1401 QGNCDQVESWMVAREN---SLRSDD--KSSLDSLEALMKKRDDLDKAITAQEGKITDLEH 1455
+ + D++E + EN LR + +D + + + + L+
Sbjct: 4439 EFH-DKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKR 4497
Query: 1456 FAESLI-----ADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANL-KQFYRDL 1509
E LI AD+ A +EI +L +++ W+ +KA+ + K D L ++F+ D+
Sbjct: 4498 RGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDM 4557
Query: 1510 EELEEWISEMLPTACDESYK--DATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIE 1567
L I + D D + I+++ +T E DG E++ + LG LI
Sbjct: 4558 AALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLI- 4616
Query: 1568 CSACDGNEEA-MKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQ-RFNTSIRDFEFWLSE 1625
AC E+ +++ ++++ W++L + ++ +KL +A + ++ +++ WL
Sbjct: 4617 -FACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDN 4675
Query: 1626 AET-LLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQI 1684
L M DL + + L + + + E+ ++ ++ LN E +L T D+
Sbjct: 4676 TVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRD 4735
Query: 1685 VKKKDNVNKRFL--NVQELAAAHHEKLKEAY-ALFQFFQDLDDEESWIE--EKLIRVSSQ 1739
+ ++ + L N+ E A KL+ A AL QF L++ SW+ E+L+
Sbjct: 4736 IIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRP 4795
Query: 1740 DYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMA-EKLKDKAAVGQEEIQLRLAQFV 1798
G D + ++ L KH L+ +++AH+ ++ V E L+ A ++ RL
Sbjct: 4796 ISG-DPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMN 4854
Query: 1799 EHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINE----KNALAVRGDCGDTLAAT 1854
+ WE + + + R +L+ +L+ Q + E E ++ E ++ L+ G
Sbjct: 4855 QCWESVLQKTEEREQQLQSTLQQAQGFHS--EIEDFLLELTRMESQLSASKPTGGLPETA 4912
Query: 1855 QSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLA 1914
+ L H L + E + +G +L + + + L +K ++
Sbjct: 4913 REQLDTHMELYSQLKAKEETYNQLLDKGRLMLLS-RDDSGSGSKTEQSVALLEQKWHVVS 4971
Query: 1915 KAIAAWKLQLEDDYAFQ-EFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTL 1973
+ K +LE+ EF W+ E SL + + + + ++ +
Sbjct: 4972 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV 5031
Query: 1974 DASLQSFQQERLPEITDLKDKL-ISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLL 2032
A+ + ++++ E+ ++L +Q I+ ++ RWE++++ S +
Sbjct: 5032 FANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRS-------I 5084
Query: 2033 EKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQ-KDHEDFLAS 2091
E+ L A +F L +W E E +L + + + +LQ H++F +
Sbjct: 5085 ERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKT 5144
Query: 2092 LARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEAR 2151
L Q + + + +K L E ++ L ++ ++ + K R
Sbjct: 5145 LGGKQPVYDTTIRTGRALKE--------KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 5196
Query: 2152 QVKNFE---MCQEFEQNASTFLQWILETRAYFL-DGSLLKETGTLESQLEANKRKQKE-- 2205
Q K E +F + W+ + D + + + + ++A+K QKE
Sbjct: 5197 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG 5256
Query: 2206 -----IQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQI 2260
+Q +KR ++++ N D +K L+ +WD + +L + Q LEQ +
Sbjct: 5257 KRTGTVQVLKRSGRELIE---NSRDDTTW-VKGQLQELSTRWDTVCKLSVSKQSRLEQAL 5312
Query: 2261 QAKDI 2265
+ ++
Sbjct: 5313 KQAEV 5317
Score = 187 bits (474), Expect = 1e-46
Identities = 412/2034 (20%), Positives = 813/2034 (39%), Gaps = 257/2034 (12%)
Query: 22 EEIQERR---QEVLTRYQSFKERVAERGQKLEDSYH-LQVFKRDADDLGKWIMEKVNILT 77
EE+Q + +E+ R + F+E +K+E + H L++F D LG N+
Sbjct: 3436 EELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF----DALGSQACSNKNL-- 3489
Query: 78 DKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELR 137
++ + + Q+LE +V L + + H+ A E L
Sbjct: 3490 -------EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLE 3542
Query: 138 -----HLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWER 192
+ +++E LE Q + ++ + AD+ + + AI G D
Sbjct: 3543 VKQRVNSGCVMMENKLEGIGQF--HCRVREMFSQLADLDDELDGMGAI------GRD--- 3591
Query: 193 TEVLHKKFEDFQVELVAKEGRVVEVNQYANECA----EENHPDLPLIQSKQNEVNAAWER 248
T+ L + ED ++ L +++ EC EE DL ++ + +N +
Sbjct: 3592 TDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGK 3651
Query: 249 L--RGLALQRQKALSNAANLQRFKRDV------------TEAIQWIKEKEPVLTSEDYGK 294
L RG A Q Q L+ ++ F R + EA+QW+ E + ++
Sbjct: 3652 LTERGKARQEQLELT-LGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ--- 3707
Query: 295 DLVASEGLFHSHK--GLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSW 352
+A +F + L+ L ++ + L A K D ++ E++ + W
Sbjct: 3708 --LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK-----DCDVQGLEHDMEEINARW 3760
Query: 353 EHIRALATSRYEKLQATYWY-HRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411
+ R +LQ + +F + L W+ + I + P+ A +V+ +
Sbjct: 3761 NTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPS--AEYKVVKAQ 3818
Query: 412 HQQHKHEIDSYDDRFQSAD----ETGQDLVNANHEASDEVREKMEILDNNWTALLELWDE 467
Q+ K DDR + D E G+ +A +++ ++E L++ WT LL
Sbjct: 3819 IQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAA 3878
Query: 468 RHRQYEQCLDF-HLFYRDSEQVDSWMSRQEAFLEN-EDLGNSLGSAEALLQKHEDFEEAF 525
R +Q E L F+ +E + ++S E L N E +G + + +H+ EE
Sbjct: 3879 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3938
Query: 526 TAQEEKIITVDKTATKLIGDDHYDSENIKAIR-DGLLARRDALREKAATRRRLLKESLLL 584
+ K L + + + + D L AR ++++ + LL ++L
Sbjct: 3939 ENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSN 3998
Query: 585 QKLY-EDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKE----LAVNKTQLEN 639
+L+ ED ++ NW+ + + KD KQ V ++ LA+N+ ++ N
Sbjct: 3999 ARLFGEDEVEVLNWLAEVEDKLSSVFVKDF--------KQDVLHRQHADHLALNE-EIVN 4049
Query: 640 IQKTGQEMIEGGHYASDNVTTRLSEVASLWEEL---------LEATKQKGTQLHEANQQL 690
+K + I+ G T EV + E+L + T K + E +QL
Sbjct: 4050 RKKNVDQAIKNGQALLKQTTGE--EVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL 4107
Query: 691 --QFENNAEDLQRWLEDVEWQVTSED----YGKGLAEVQNRLRKHGLLESAVAARQDQVD 744
+F++ E+L WL +VE ++ + G+ + + Q R ++ L+ V + +D
Sbjct: 4108 ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE---LKKEVMEHRLVLD 4164
Query: 745 ILTDLAAYFEEIGHPDSKDIRARQ--ESLVC----RFEALKEPLATRKKKLLDLLHLQLI 798
+ +++ E+ RAR+ + LV +++ + + + R ++ +
Sbjct: 4165 TVNEVSRALLEL-----VPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219
Query: 799 CRDTEDEE-AWIQET------------EPSATSTYLGKDLIASKKLLNRHRVILENIASH 845
D E AW+ ET E T+ L S ++ RH+ ++ + SH
Sbjct: 4220 YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDII-RHKDSMDELFSH 4278
Query: 846 EPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE-ANVQFQQY 904
I K V + + +SL Q E++ + R LE A V Q+
Sbjct: 4279 RSEIFGTCGEEQKTV---------LQEKTESLIQQYEAISLLNSERYARLERAQVLVNQF 4329
Query: 905 LADLHEAETWIREKE--------PIVDNTNYGADEEAAGAL---LKKHEAFLLDLNSFGD 953
E WI E P +D+ +E L + +H+ + L G
Sbjct: 4330 WETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 4389
Query: 954 SMKALRNQANACQQQQAAPVEGVAGE------QRVMALYDFQARSPR--EVTMKKGDVLT 1005
+K L + +++ E + + QR +AL + ++S + E K +L
Sbjct: 4390 QLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLE 4449
Query: 1006 LLSSINK----------DWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGN--- 1052
L +++ + K+ V + +L F L +R E G
Sbjct: 4450 TLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKL-QPSFEALKRRGEELIGRSQG 4508
Query: 1053 ---------ITQRQEQIENQYRSLLDRAEERRRR---LLQRYNEFLLAYEAGDMLEWIQE 1100
I + +Q+ + + RAEER + +L+ +F Y+ +L I++
Sbjct: 4509 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFW--YDMAALLTTIKD 4566
Query: 1101 KK-----AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLT--PE 1153
+ E+ G++ + + + + +++ + L I + DL+F T PE
Sbjct: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626
Query: 1154 GAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTK-EQIEKKCQALSAADP- 1211
+ E+N+ W +L + E+ + L A V +++ + ++ L P
Sbjct: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4686
Query: 1212 GSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATE-DLQRQKM-ELNE 1269
G+DL +V+ + F+ ++ ++ L E + + D T+ D+ R+ + EL
Sbjct: 4687 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4746
Query: 1270 AWEDLQGRTKDRKESLNEAQ-KFYLFLSKARDLQNWISSIGGMVSSQE-LAEDLTGIEIL 1327
WE+L + R+ L A F +L +W++ ++ +Q ++ D IE+
Sbjct: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806
Query: 1328 LERHQEHRADMEAEAPTFQALEDFSAELIDS--GHHASPEIEKKLQAVKLERDDLEKAWE 1385
L +H + D+ A T + + EL++S G AS + +L+A+ + + + E
Sbjct: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDAS-SLRSRLEAMNQCWESVLQKTE 4865
Query: 1386 KRKKILDQCLELQMFQGNCDQVESWMV--ARENSLRSDDKSSLDSLEALMKKRD---DLD 1440
+R++ L L Q QG ++E +++ R S S K + E ++ D +L
Sbjct: 4866 EREQQLQSTL--QQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY 4923
Query: 1441 KAITAQEGKITDLEHFAESLIA--DEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGD 1498
+ A+E L ++ D+ + + + + +W + +++ + ++KL +
Sbjct: 4924 SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4983
Query: 1499 YANLK-QFYRDLEELEEWISEMLPTACDESYKDAT-------NIQRKYLKHQTFAHEVDG 1550
NL +F L+E W+ T ++S A+ + + +H+ FA+EV+
Sbjct: 4984 ALNLATEFQNSLQEFINWL-----TLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 5038
Query: 1551 RSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEA-SRQ 1609
+Q+ + GN L S + +K L ++ W+ +++R+ ++G+ L++A R
Sbjct: 5039 HRDQIIELDQTGNQLKFLSQKQ-DVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA 5097
Query: 1610 QRFNTSIRDFEFWLSEAETLLAMK-DQARDLASAGNLLKKHQLLEREMLARED------- 1661
++F+ + + WL +AE+ L + + + D L KH+ ++ + ++
Sbjct: 5098 KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 5157
Query: 1662 ---ALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF-Q 1717
ALK+ L ED F + ++ K D V + + Q KL+EA Q
Sbjct: 5158 TGRALKEKTLLPEDSQKLDNF-LGEVRDKWDTVCGKSVERQH-------KLEEALLFSGQ 5209
Query: 1718 FFQDLDDEESW---IEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLD 1774
F L W +E +L Q DL V NL+ HK + EL +Q +
Sbjct: 5210 FMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKR 5267
Query: 1775 MAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQ-FMQNAEEEEA 1833
+L + + ++ +L + W+ + +L+ ++ +LE++L+ + F
Sbjct: 5268 SGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327
Query: 1834 WINE-KNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDIL 1886
W++E + L RG D A QSL+ H+ V + A GE IL
Sbjct: 5328 WLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVIL 5381
Score = 179 bits (454), Expect = 3e-44
Identities = 493/2661 (18%), Positives = 1023/2661 (38%), Gaps = 398/2661 (14%)
Query: 7 ETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLE-DSYHLQVFKRDADDL 65
+ VE KVL +++ R Q++ + + +G E D L + + +DL
Sbjct: 1910 QNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDL 1969
Query: 66 GKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKS--RLMSELEKTREERFTMGH 123
+ + E+ L +++ IQ +H + Q + RL++EL+++ ++
Sbjct: 1970 KQPMAERKAQLDALAFD----IQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDIL---- 2021
Query: 124 SAHEETKAHIEELR-HLWDLLLELTLEKGDQLLRALKFQQYV--QECADILEWIGDKEAI 180
E+T A ++ L+ HL + + + L++ L+ QQ Q+ D+ W+G E
Sbjct: 2022 ---EQTAAQVDALQGHLQQM-------EQEALVKTLQKQQNTCHQQLEDLCSWVGQAERA 2071
Query: 181 ATSVELGEDWERTEVLHKK---FEDFQVELVAKEGRVVEVNQYANECAEENHP-----DL 232
+ + L K +D Q ++ + V + EEN +L
Sbjct: 2072 LAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL 2131
Query: 233 PLIQSKQNEVNAAWERLRG--------------LALQRQKALSNAAN-LQRFKRDVTEAI 277
++ K ++ +E L+ ALQ++ S AA L K+ + +
Sbjct: 2132 TALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALL 2191
Query: 278 QWIK------------------------EKEPVLTSEDYGKDLVASEGLFHSHKGLERNL 313
W+ EK + T++ Y G+ + + L++
Sbjct: 2192 DWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGY-------MGVNQAPEKLDKQC 2244
Query: 314 AVMSDKVKELCAKAEKLTLSHPSD-----------APQIQEMKEDLVSSW--EHIRALAT 360
+M + +EL ++ + L+ S P+ Q+M + + ++ +LA
Sbjct: 2245 EMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQ 2304
Query: 361 SRYEKLQATYWY---HRFSSDFDELSGWMNEKTAAINADELPTDVAGGEV------LLDR 411
S E Q +F D E W+ + EL GG LL R
Sbjct: 2305 SEAELKQVQTLQDELQKFLQDHKEFESWLER-----SEKELENMHKGGSSPETLPSLLKR 2359
Query: 412 HQQHKHEIDSYDDRFQSADETGQDLVNANH---------EASDEVREKMEILDNNWTALL 462
++ S+ + +GQ +++ + E + V++K++ +TAL
Sbjct: 2360 QGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALH 2419
Query: 463 ELWDERHRQYEQCL-DFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKH--- 518
L +H F ++ + +WM EA +E L +++ S +LQ+
Sbjct: 2420 SKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKL-LSDTVASDPGVLQEQLAT 2478
Query: 519 -EDFEEAFTAQE---EKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATR 574
+ +E + EK+ V + ++ G+ D +++ D +L+ +L A R
Sbjct: 2479 TKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAER 2538
Query: 575 RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQV-----FEKE 629
LL++++ + ++S L++ + ++ + + K + +L S V ++ + +++
Sbjct: 2539 SSLLQKAIAQSQSVQES--LESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2596
Query: 630 LAVNKTQLENIQKTGQEMIEGGHYASDNVTT-----RLSEVASLWEELLEATKQKGTQLH 684
+A K+ LE +EM+ +D+ T +L+EV+ +E+L ++K + L
Sbjct: 2597 IARQKSSLE----ATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLK 2652
Query: 685 EANQQLQ-FENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQV 743
+ Q + FE+ + LQ+++E+ + S + ++ + ++ L + +Q+ +
Sbjct: 2653 KLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPD--QDITHFFQQIQELNLEMEDQQENL 2710
Query: 744 DILTDLAAYFEEIGHP-DSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT 802
D L L G D + R ++L F L++ + R+K C++
Sbjct: 2711 DTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASS-------CQEQ 2763
Query: 803 EDE--------EAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITE 854
DE + W++ETE S T +K + + +L++ AS ++EI
Sbjct: 2764 LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINC 2823
Query: 855 RGNKMVE----------------------------EGHFAAED---VASRVKSLNQNMES 883
+G + G+ +D + + +N E
Sbjct: 2824 KGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEK 2883
Query: 884 LRARAARRQNDLEANV-QFQQYLADLHEAETWIREKEPI---VDNTNYGADEEAAGALLK 939
L RQ L+A + + ++ + + W+ KE + +D + E A +
Sbjct: 2884 LGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAE 2943
Query: 940 KHEAFLLDLNSFGDSMKALRN---------------------QANACQQQQAAPVEGVAG 978
++AFL +L ++ ++ Q + + A VA
Sbjct: 2944 SNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVAR 3003
Query: 979 EQRV------MALYDFQARSPREVTMKKGDVLTLLS--SINKDWWKVEAADHQGIVPAVY 1030
++++ +A + R M+K ++ +L SI+ + + Q ++
Sbjct: 3004 QRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFE 3063
Query: 1031 VRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNE----FL 1086
RR H++ Q PG+++ Q++ + +S+ + E +L R ++ +
Sbjct: 3064 ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIV 3123
Query: 1087 LAYEAGDMLEWIQEK-KAENTGVELDDVWELQ--------KKFDEFQKDLNTNEPRLRDI 1137
+ + ++L+ + EK +A + + Q ++ E + DL + +++
Sbjct: 3124 KSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEA 3183
Query: 1138 NKVADD---LLFEGLLTPEGAQIRQELNSRWGSLQRL----ADEQRQLLGSAHAVEVFHR 1190
+ D+ L+ E L E +++ L + LQ L AD +L + + + F +
Sbjct: 3184 QTLCDELSVLIGEQYLKDE---LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ 3240
Query: 1191 EADDTKEQI-EKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERL 1249
D+ + + +K+ Q + L +Q+ + +E F++ L ++ E L
Sbjct: 3241 MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL 3300
Query: 1250 SESHPDATE--DLQRQKMELNEAWEDLQGRTKDRKESLNEA-QKFYLFLSKARDLQNWIS 1306
S P E LQ Q +EL WE+L +T DR+ L + QK + DL WI
Sbjct: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 3360
Query: 1307 SIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEI 1366
+S + D +E L R + ++E + L + LI+S I
Sbjct: 3361 DCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI 3420
Query: 1367 EKKLQAVKLERDDLEKAWEKRKKILDQCLE-LQMFQGNCDQVESWMVARENSLRSDDK-- 1423
+ + D + + + + L++ + L+ FQ + +E + ++ L D
Sbjct: 3421 RDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG 3480
Query: 1424 SSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLI------ADEHYAKEEIATRLQR 1477
S S + L K R + + A E ++ L +F + L+ +D + Q
Sbjct: 3481 SQACSNKNLEKLRAQ-QEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQE 3539
Query: 1478 VLDRWKALKAQLIDERTKLGD----YANLKQFYRDLEELEEWISEMLPTACDESYKDATN 1533
L+ + + + + KL + +++ + L +L++ + M +D +
Sbjct: 3540 FLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIG-----RDTDS 3594
Query: 1534 IQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE-------AMKEQLEQLK 1586
+Q + + F +++ V+ L E EE +K +LE L
Sbjct: 3595 LQSQIEDVRLFLNKIH--------VLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALN 3646
Query: 1587 EHWDHLLERTNDKGKKLN-EASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNL 1645
+ L ER + ++L R + F ++ L++A T + + +
Sbjct: 3647 KQCGKLTERGKARQEQLELTLGRVEDFYRKLKG----LNDATTAAEEAEALQWVVGTEVE 3702
Query: 1646 LKKHQLLEREMLAREDA------LKDLNTLAEDLLSSG--TFNVDQIVKKKDNVNKRFLN 1697
+ QL + +M +E L+ +N L + L+ S +V + + +N R+
Sbjct: 3703 IINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNT 3762
Query: 1698 VQELAAAHHEKLKEAYALFQFFQD-LDDEESWI--EEKLIRVSSQDYGRDLQGVQNLLKK 1754
+ + A +L+EA FQD L+ SW+ E+LI + + + + V+ +++
Sbjct: 3763 LNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-ANQKPPSAEYKVVKAQIQE 3821
Query: 1755 HKRLEGELVAHEPAIQNVLDMAEKLKDKAAVG-QEEIQLRLAQFVEHWEKLKELAKARGL 1813
K L+ L + + + ++ A + +E+I +L W +L A AR
Sbjct: 3822 QKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3881
Query: 1814 KLEESLEYL-QFMQNAEEEEAWIN-EKNALAVRGDCGDTLAATQSLLMKHEALENDFAVH 1871
+LE+ L QF + AE +++ + LA G A Q +++H+ALE D H
Sbjct: 3882 QLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENH 3941
Query: 1872 ETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALN-----------EKTPSLAKAIAAW 1920
T V G+ + + L ++ +S KI++L K L +A++
Sbjct: 3942 ATDVHQAVKIGQSLSS--LTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNA 3999
Query: 1921 KLQLEDDYAFQEFNWKADVVE----AWIADKETSLKTNGNGADLGDFLTLLAKQDTLDAS 1976
+L ED+ + NW A+V + ++ D + + + L ++ ++ +D +
Sbjct: 4000 RLFGEDE--VEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQA 4057
Query: 1977 LQSFQ----QERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLL 2032
+++ Q Q E+ +++KL I+ RYA + V K L
Sbjct: 4058 IKNGQALLKQTTGEEVLLIQEKL--------DGIKTRYADI-----------TVTSSKAL 4098
Query: 2033 EKQLPLQKAEDLFVEFAHKASALNNWCEKMEENL-SEPVHCVSLNEIRQLQKDHEDFLAS 2091
L++A L +F L W ++EE L + + +I Q Q+ ++
Sbjct: 4099 R---TLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKE 4155
Query: 2092 LARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLER-------TWKHLSDIIEEREQE 2144
+ + + E+ + + L VP W E L++ +K +SD I +R E
Sbjct: 4156 VMEHRLVLDTVNEVSRALLEL-VP-----WRAREGLDKLVSDANEQYKLVSDTIGQRVDE 4209
Query: 2145 LQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLD-GSLLKETGTLESQLEANKRKQ 2203
+ R Q++EQ A L W+ ET+ + G + E +QL+ K
Sbjct: 4210 IDAAIQRS-------QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS 4262
Query: 2204 KEIQAMKRQLTKIVDLGDNL------EDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLE 2257
+I K + ++ + E +L K T L QQ++ + L LE
Sbjct: 4263 IDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEK--TESLIQQYEAISLLNSERYARLE 4320
Query: 2258 Q-QIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHE 2316
+ Q+ EE + + + H++ R + + EH+
Sbjct: 4321 RAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIA--EHK 4378
Query: 2317 PKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKEDM 2376
P +K L + P K N + + +E +Q + I +E
Sbjct: 4379 PHIDKLL-KIGPQLK----------------ELNPEEGEMVEEKYQKAENMYAQIKEEVR 4421
Query: 2377 KQALTPEQVSFCATHMQQYMD 2397
++AL ++ +T + ++ D
Sbjct: 4422 QRALALDEAVSQSTQITEFHD 4442
Score = 173 bits (439), Expect = 2e-42
Identities = 426/2329 (18%), Positives = 930/2329 (39%), Gaps = 168/2329 (7%)
Query: 19 ETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTD 78
+ +E+Q Q+ + R ++ Q + S Q +D + + + +++++ +
Sbjct: 3092 QVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSA 3151
Query: 79 KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAH--EETKAHIEEL 136
S + P ++ + ++ + ++++ + E + +E + + +E K +E +
Sbjct: 3152 ISTQ-PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV 3210
Query: 137 RHLWDLLLELTLEKGDQLLRALKFQQYVQECADILE-WIGDKEAI-ATSVELGEDWERTE 194
L +L ++ ++L AL Q Q+ D L W+ DK++ A + + ER +
Sbjct: 3211 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 3270
Query: 195 VLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHP--DLPLIQSKQNEVNAAWERLRGL 252
++ E+FQ L G + P + +Q++ E+ WE L
Sbjct: 3271 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 3330
Query: 253 ALQRQKALSNAAN-LQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLER 311
RQ L + Q+++ V + + WI++ + ++ D V E K +
Sbjct: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 3390
Query: 312 NLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQA-TY 370
+ ++ L + A+ L S +D I++ K + + + + ++ L+ T
Sbjct: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQ 3450
Query: 371 WYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSAD 430
F F + + + + A L++ + + + + + +
Sbjct: 3451 RLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLR 3510
Query: 431 ETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDS 490
Q LV + SD ++L A E + + R C+ + E +
Sbjct: 3511 NFTQGLVEDAPDGSDA----SQLLHQAEVAQQEFLEVKQRVNSGCV---MMENKLEGIGQ 3563
Query: 491 WMSR-QEAFLENEDLGNSLGSAEALLQKHEDFEEAFT-----AQEEKIITVDKTATK--- 541
+ R +E F + DL + L A+ + + + + ++ +D A++
Sbjct: 3564 FHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAEC 3623
Query: 542 ---LIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWI 598
L + D +K + L + L E+ R+ L+ L L ++ + LK +
Sbjct: 3624 RHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLE--LTLGRVEDFYRKLKG-L 3680
Query: 599 NKKKKLADDEDY------KDIQNLKSRVQKQQVFEKE-LAVNKTQLENIQKTGQEMIEGG 651
N A++ + +++ + ++ ++F+KE + + +L+ + GQ +I+
Sbjct: 3681 NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSA 3740
Query: 652 HYASD--NVTTRLSEVASLWEELLEATKQKGTQLHEANQQL-QFENNAEDLQRWLEDVEW 708
D + + E+ + W L + Q+ QL EA +F++ E L WL D E
Sbjct: 3741 GKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEE 3800
Query: 709 QVTSEDYGKGLAEV-QNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGH-PDSKDIRA 766
+ ++ +V + ++++ LL+ + R+ VD+L + D + I
Sbjct: 3801 LIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITG 3860
Query: 767 RQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT-EDEEAWIQETEPS-ATSTYLGKD 824
+ ESL R+ L A R+K+L D+L L +T E ++ TE A S +G
Sbjct: 3861 QLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQ 3920
Query: 825 LIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVAS-RVKSLNQNMES 883
++ + RH+ + E+I +H + + + G + A + V S ++ SL
Sbjct: 3921 TAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSE 3980
Query: 884 LRARAARRQNDLEANVQFQQYLA-DLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHE 942
++ R R+ L+ + + D E W+ E E D + ++ +L +
Sbjct: 3981 IQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE---DKLSSVFVKDFKQDVLHRQH 4037
Query: 943 AFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPR--EVTMKK 1000
A L LN + + +N A + QA ++ GE+ ++ R ++T+
Sbjct: 4038 ADHLALNE--EIVNRKKNVDQAIKNGQAL-LKQTTGEEVLLIQEKLDGIKTRYADITVTS 4094
Query: 1001 GDVLTLLSSINKDWWKVEAADHQ--GIVPAVYVRRLAH-------DEFPMLPQRRREEPG 1051
L L + K ++ + G + V ++ P QR++E
Sbjct: 4095 SKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKK 4154
Query: 1052 NITQRQ---EQIENQYRSLLD----RAEERRRRLLQRYNEF--LLAYEAGDMLEWIQ--- 1099
+ + + + + R+LL+ RA E +L+ NE L++ G ++ I
Sbjct: 4155 EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI 4214
Query: 1100 ---EKKAENTGVELDDVWELQKKF----------DEFQKDLNTNEPRLRDINKVAD--DL 1144
++ + EL V E ++K D+ L + DI + D D
Sbjct: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 4274
Query: 1145 LFE------GLLTPEGAQIRQE----LNSRWGSLQRLADEQRQLLGSAHA-VEVFHREAD 1193
LF G E + QE L ++ ++ L E+ L A V F +
Sbjct: 4275 LFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYE 4334
Query: 1194 DTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFE-RDLV----PLGDKVTILGETAER 1248
+ IE+ +AL A P + Q Q++ E + R+ + P DK+ +G +
Sbjct: 4335 ELSPWIEET-RALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE 4393
Query: 1249 LSESHPDATED-LQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISS 1307
L+ + E+ Q+ + + E+++ R E+++++ + F K + + +
Sbjct: 4394 LNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLEN 4453
Query: 1308 IGGMVSSQELAE-DLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHA---- 1362
+ + L ++ I + ++ ++E P+F+AL+ ELI A
Sbjct: 4454 LSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDL 4513
Query: 1363 -SPEIEKKLQAVKLERDDLEKAWEKRK-KILDQCLELQMFQGNCDQVESWMVARENSLRS 1420
+ EI+ KL + +D++ E+R+ K LD + F + + + + ++ +
Sbjct: 4514 AAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHD 4573
Query: 1421 DDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYA-----KEEIATRL 1475
+ +D +++K++ + + I + + + F L AD +A K E+ +
Sbjct: 4574 LESPGIDP--SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4631
Query: 1476 QRVLDRWKALKAQLIDERTKLGDYANLKQFYRD-LEELEEWISEMLPTACDESY--KDAT 1532
+ + W+ L + KL D Y+D L+ + +W+ + C D
Sbjct: 4632 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLN 4691
Query: 1533 NIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHL 1592
++ + + + F EV + ++ + + G +++ + + + + ++E L +LK W++L
Sbjct: 4692 TVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENL 4751
Query: 1593 LERTNDKGKKLNEASRQQ-RFNTSIRDFEFWLSEAETLL-AMKDQARDLASAGNLLKKHQ 1650
E+ + KL A +F ++ + WL+ E LL A + + D L KH
Sbjct: 4752 GEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHH 4811
Query: 1651 LLEREMLAREDALKDLNTLAEDLL-SSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKL 1709
+L+ ++LA + ++ +N +LL SS + + + + +N+ + +V + ++L
Sbjct: 4812 VLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQL 4871
Query: 1710 KEAYALFQ-FFQDLDD---EESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAH 1765
+ Q F +++D E + +E +L +S+ G + + L H L +L A
Sbjct: 4872 QSTLQQAQGFHSEIEDFLLELTRMESQLS--ASKPTGGLPETAREQLDTHMELYSQLKAK 4929
Query: 1766 EPAIQNVLDMAEKL---KDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYL 1822
E +LD + +D + G + Q +A + W + + R KLEE+L
Sbjct: 4930 EETYNQLLDKGRLMLLSRDDSGSGSKTEQ-SVALLEQKWHVVSSKMEERKSKLEEALNLA 4988
Query: 1823 QFMQNAEEEEA-WIN-EKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCA 1880
QN+ +E W+ + +L + L S + +H+ N+ H ++ +
Sbjct: 4989 TEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQ 5048
Query: 1881 QGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYA-FQEFNWKADV 1939
G + K L ++ I + + ++ + + + L+D ++F+
Sbjct: 5049 TGNQL--KFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKK 5106
Query: 1940 VEAWIADKETSLKTNGNGADLGDFLTL-LAKQDTLDASL---QSFQQERLPEITDLKDKL 1995
+ W+ D E+ L + ++ D + L L+K +L Q + LK+K
Sbjct: 5107 LIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKT 5166
Query: 1996 ISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASAL 2055
+ + +Q ++ + +W+ + S +E+Q L++A +F AL
Sbjct: 5167 LLPEDSQK--LDNFLGEVRDKWDTVCGKS-------VERQHKLEEALLFSGQFMDALQAL 5217
Query: 2056 NNWCEKMEENLSE--PVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALG 2113
+W K+E L+E PVH L+ + L H+ F L + + L +++
Sbjct: 5218 VDWLYKVEPQLAEDQPVH-GDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENS 5276
Query: 2114 VPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173
+ + ++ L W + + ++ L++ + + F L+W+
Sbjct: 5277 RDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQA-------LKQAEVFRDTVHMLLEWL 5329
Query: 2174 LET-RAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGD 2221
E + G+L +T L+S ++ +K K+++ + + V +G+
Sbjct: 5330 SEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGE 5378
Score = 156 bits (394), Expect = 3e-37
Identities = 446/2445 (18%), Positives = 939/2445 (38%), Gaps = 294/2445 (12%)
Query: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIMEKVNILTDKSYE 82
+QE +L+ +QS +AER L+ + Q + + L + I E L K
Sbjct: 2517 VQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVS 2576
Query: 83 DPTN--IQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIE----EL 136
++ IQ + L+ ++ +R S LE TRE +A T A ++ E+
Sbjct: 2577 SLSSGVIQEALATNMKLKQDI---ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEV 2633
Query: 137 RHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEA--IATSVELGED----W 190
++ L EK L + L + + + L+ + ++ +A+ + +D +
Sbjct: 2634 SQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFF 2693
Query: 191 ERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLR 250
++ + L+ + ED Q L E V E++ DL Q + + + L+
Sbjct: 2694 QQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL------DLCQHQDRVQNLRKDFTELQ 2747
Query: 251 GLALQRQKALSNAAN-LQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGL 309
+R+K S+ L F++ V +W+KE E + + E K L
Sbjct: 2748 KTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSL 2807
Query: 310 ERNLAVMSDKVKELCAKAEKLT-----LSHPS--------------------------DA 338
+ A V+E+ K L ++ P D
Sbjct: 2808 LDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL 2867
Query: 339 PQIQEMKEDLVSSWEHIRALATSRYEKLQATY-WYHRFSSDFDELSGWMNEKTAAI---N 394
+IQ D+ +E + + R E LQA + + + W+ K + +
Sbjct: 2868 TEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMD 2927
Query: 395 ADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADET--GQDLVNANHEASDEVREKME 452
A PT + + ++ E++ + Q E G + N + ++ ++ E
Sbjct: 2928 AMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQE 2987
Query: 453 ILDNNWTALLELWDERHRQYEQCLDFHLFYRDSE-QVDSWMSRQEAFL------------ 499
L++ W E+ R RQ E+ ++ +E Q+ W+ +E +
Sbjct: 2988 ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNM 3047
Query: 500 ---ENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAI 556
+ + + L EA Q+HE EA + I+T GD + ++
Sbjct: 3048 LNAQKQQVQFMLKEFEARRQQHEQLNEA----AQGILTGP-------GDVSLSTSQVQKE 3096
Query: 557 RDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNL 616
+ + L +K +R + ++++ Y++ L++ K + + + +
Sbjct: 3097 LQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQEL--LQDLSEKVRAVGQRLSVQSAIST 3154
Query: 617 KSRVQKQQVFE-KELAVNKTQLENIQKTGQEMIE------GGHYASDNVTTRLSEVASLW 669
+ KQQ+ E E+ + QL++ K Q + + G Y D + RL VA
Sbjct: 3155 QPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL 3214
Query: 670 EELLEATKQKGTQLHEANQQLQ-FENNAEDLQRWLEDVEWQVTSE-DYGKGLAEVQNRLR 727
+ L + + +L A Q F+ ++L+ WL+D + Q L +Q++L+
Sbjct: 3215 QGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQ 3274
Query: 728 KHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLV---CRFEALKEPLAT 784
++ + ++ +++ + P ++ R Q LV +E L + A
Sbjct: 3275 ENEEFQKSLNQHSGSYEVIVAEGESLL-LSVPPGEEKRTLQNQLVELKNHWEELSKKTAD 3333
Query: 785 RKKKLLDLLH-LQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIA 843
R+ +L D + Q ED WI++ + + + D + + L R + +L +
Sbjct: 3334 RQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVE 3393
Query: 844 SHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQ--- 900
++ + + ++ + + +NQNM+++ + LE Q
Sbjct: 3394 KRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLR 3453
Query: 901 -FQQYLADL--------HEAETWIREKEPIVDNTN---YGADEEAAGAL------LKKHE 942
FQ+ ++ H+ E + N N A +E AL L+
Sbjct: 3454 EFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFT 3513
Query: 943 AFLLDLNSFGDSMKALRNQANACQQQ-----QAAPVEGVAGEQRVMALYDFQARSPREVT 997
L++ G L +QA QQ+ Q V E ++ + F R RE+
Sbjct: 3514 QGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR-VREMF 3572
Query: 998 MKKGDV---LTLLSSINKDWWKVEA--ADHQGIVPAVYV------------RRLAHDE-- 1038
+ D+ L + +I +D +++ D + + ++V R + +E
Sbjct: 3573 SQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGT 3632
Query: 1039 FPMLPQRRREEP-----GNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGD 1093
+L +R E G +T+R + + Q L R E+ R+ L+ N+ A E +
Sbjct: 3633 LDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRK-LKGLNDATTAAEEAE 3691
Query: 1094 MLEWIQEKKAENTGVELDDVWELQKKFDEFQKD-LNTNEPRLRDINKVADDLLFEGLLTP 1152
L+W+ G E++ + + F FQK+ ++ + +L+ +N L +GL+
Sbjct: 3692 ALQWV-------VGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNG-----LGQGLIQS 3739
Query: 1153 EGAQI--------RQELNSRWGSL-----QRLADEQRQLLGSA---HAVEVFHREADDTK 1196
G +E+N+RW +L QR+A Q LL A+E DT+
Sbjct: 3740 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3799
Query: 1197 EQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDA 1256
E I + P ++ V+A + + +R L V +L R+++S A
Sbjct: 3800 ELIANQ------KPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA 3853
Query: 1257 -TEDLQRQKMELNEAWEDLQGRTKDRKESLNE----AQKFYLFLSKARDLQNWIS-SIGG 1310
E + Q L W +L + R++ L + A++F+ A + +++S +
Sbjct: 3854 DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFH---ETAEPISDFLSVTEKK 3910
Query: 1311 MVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEI-EKK 1369
+ +S+ + I+ + RH+ D+E A L A + +K
Sbjct: 3911 LANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEK 3970
Query: 1370 LQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVE--SWMVARENSLRS----DDK 1423
+ +++ +++ ++ +LDQ L G D+VE +W+ E+ L S D K
Sbjct: 3971 IDSLQARYSEIQDRCCRKAALLDQALSNARLFGE-DEVEVLNWLAEVEDKLSSVFVKDFK 4029
Query: 1424 SSL------DSL---EALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATR 1474
+ D L E ++ ++ ++D+AI + + LI ++ + I TR
Sbjct: 4030 QDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK---LDGIKTR 4086
Query: 1475 LQRV-LDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATN 1533
+ + KAL+ +++ +L +F EEL W+ E+ + T
Sbjct: 4087 YADITVTSSKALRT--LEQARQLA-----TKFQSTYEELTGWLREVEEELATSGGQSPTG 4139
Query: 1534 IQ-------RKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLK 1586
Q +K LK + H + + V+ V L+ A +G ++ + + EQ K
Sbjct: 4140 EQIPQFQQRQKELKKEVMEHRL--VLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYK 4197
Query: 1587 EHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAE-TLLAMKDQARDLASAGNL 1645
D + +R ++ + R Q++ + W++E + L+A+ +
Sbjct: 4198 LVSDTIGQRVDEIDAAI---QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ 4254
Query: 1646 LKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQ---IVKKKDNVNKRFLNVQELA 1702
L+ + +++ +D++ +L + ++ GT +Q + +K +++ +++ + L
Sbjct: 4255 LQVQKAFSIDIIRHKDSMDELFSHRSEIF--GTCGEEQKTVLQEKTESLIQQYEAISLLN 4312
Query: 1703 AAHHEKLKEAYALF-QFFQDLDDEESWIEE-KLIRVSSQDYGRDLQGVQNLLKKHKRLEG 1760
+ + +L+ A L QF++ ++ WIEE + + D + ++ ++ ++L
Sbjct: 4313 SERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 4372
Query: 1761 ELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESL- 1819
+ H+P I +L + +LK+ E ++ + + + ++KE + R L L+E++
Sbjct: 4373 SIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVS 4432
Query: 1820 EYLQFMQNAEEEEAWINEKNALAVR-----------GDCGDTLAATQSLLMKHEALENDF 1868
+ Q + ++ E + L+ R + ++ +S ++ E L+ F
Sbjct: 4433 QSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSF 4492
Query: 1869 AVHETRVQNVCAQGEDILNKV--LQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLED 1926
+ R GE+++ + ++ KEI K++ + + +++ D
Sbjct: 4493 EALKRR-------GEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLD 4545
Query: 1927 DYAFQEFNWKADVVEAWIADKETS---LKTNGNGADLGDFLTLLAKQDTLDASLQSFQQE 1983
E W D+ K+T G D + +T+ +E
Sbjct: 4546 VLELAEKFW-YDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEE 4604
Query: 1984 RLPEITDL-KDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE 2042
L I L D + + + + + + WE L + ++ LEK L+ A
Sbjct: 4605 -LEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT----WKERLEK---LEDAM 4656
Query: 2043 DLFVEFAHKASALNNWCEKMEENL-SEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKC 2101
V++ A+ +W + L + P LN ++ + ++F + + Q + +
Sbjct: 4657 QAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEK 4716
Query: 2102 LLELDQQI--KALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMC 2159
L + + KA + L+ W++L + I R+ +L+
Sbjct: 4717 LNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGA-------LLAL 4769
Query: 2160 QEFEQNASTFLQWILETRAYFLDGS--LLKETGTLESQLEANKRKQKEIQAMKRQLTKIV 2217
+F+ + W+ T LD + + +E +L + + ++ A + + +
Sbjct: 4770 GQFQHALEELMSWLTHTEE-LLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4828
Query: 2218 DLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQA 2262
G+ L ++ D S + +Q ++ L+ EQQ+Q+
Sbjct: 4829 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQS 4873
Score = 137 bits (346), Expect = 1e-31
Identities = 187/903 (20%), Positives = 385/903 (42%), Gaps = 60/903 (6%)
Query: 23 EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDA-DDLGKWIMEKVNILTDKSY 81
E+++ E+ +++ + ER +KLED+ V +D + W+ V L
Sbjct: 4626 EVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4685
Query: 82 EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHI-----EEL 136
K Q ++ E +V+ + + E+EK + M A +ET I EL
Sbjct: 4686 VGTDLNTVKDQLNEMKEFKVEVYQQQI-EMEKLNHQGELMLKKATDETDRDIIREPLTEL 4744
Query: 137 RHLWDLLLELTLEKGDQLLRAL-KFQQYVQECADILEWIGDKEAIATSVE-LGEDWERTE 194
+HLW+ L E + +L AL Q+ +++ W+ E + + + D + E
Sbjct: 4745 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE 4804
Query: 195 VLHKKFEDFQVELVAKEGRVVEVNQYANECAEENH-PDLPLIQSKQNEVNAAWERLRGLA 253
V K + +++A + V VN+ NE E + D ++S+ +N WE +
Sbjct: 4805 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4864
Query: 254 LQRQKAL-SNAANLQRFKRDVTEAIQWIKEKEPVLTSEDY--GKDLVASEGLFHSHKGLE 310
+R++ L S Q F ++ + + + E L++ G A E L +H L
Sbjct: 4865 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQL-DTHMELY 4923
Query: 311 RNLAVMSDKVKELCAKAEKLTLSHPSDAP--QIQEMKEDLVSSWEHIRALATSRYEKLQ- 367
L + +L K + LS + ++ L W + + R KL+
Sbjct: 4924 SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4983
Query: 368 ATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHK---HEIDSYDD 424
A F + E W+ ++N P+ + +L + ++HK +E++++ D
Sbjct: 4984 ALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILN--TVLSQIEEHKVFANEVNAHRD 5041
Query: 425 RFQSADETGQDLVNANHEASDEVREKMEI-LDNNWTALLELWDERHRQYEQCLD-FHLFY 482
+ D+TG L + + + + + + + + W +++ ER R + F+
Sbjct: 5042 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFH 5101
Query: 483 RDSEQVDSWMSRQEAFLENE-DLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATK 541
+++ W+ E+ L++E ++ N + L KH++F++ ++ T +T
Sbjct: 5102 EAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRA 5161
Query: 542 L-----IGDDHYDSEN-IKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDS-DDL 594
L + +D +N + +RD + D + K+ R+ L+E+LL + D+ L
Sbjct: 5162 LKEKTLLPEDSQKLDNFLGEVRD----KWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 5217
Query: 595 KNWINK-KKKLADDED-YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGH 652
+W+ K + +LA+D+ + D+ + + + +VF+KEL ++ ++++G+E+IE
Sbjct: 5218 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 5277
Query: 653 YASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FENNAEDLQRWLEDVEWQVT 711
+ V +L E+++ W+ + + + K ++L +A +Q + F + L WL + E +
Sbjct: 5278 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 5337
Query: 712 SEDYGKGLAE-VQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDS--------K 762
E +Q+ + H V ++ V+ + + HPD
Sbjct: 5338 FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWIT 5397
Query: 763 DIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPS---ATST 819
IRAR E ++ + ++ L T +L+ L E+ AWIQ E +
Sbjct: 5398 IIRARFEEVLTWAKQHQQRLETALSELVANAEL------LEELLAWIQWAETTLIQRDQE 5451
Query: 820 YLGKDLIASKKLLNRHRVILENIASHEPRIQEITER-GNKMVEEGH--FAAEDVASRVKS 876
+ +++ K L+ H+ +E + +P + +T+ K +E H F + + KS
Sbjct: 5452 PIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKS 5511
Query: 877 LNQ 879
L+Q
Sbjct: 5512 LSQ 5514
Score = 75.1 bits (183), Expect = 8e-13
Identities = 230/1220 (18%), Positives = 451/1220 (36%), Gaps = 187/1220 (15%)
Query: 1281 RKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEA 1340
R+ L +K +LS R+++ I + + +DL +LER + + +
Sbjct: 1800 RQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVS 1859
Query: 1341 EAPTFQALEDFSAELIDSGHHASPEIEKKLQ--AVKLERD--DLEKAWEKRKKILDQCLE 1396
Q LE + +I ++ K L+ A L++ + W R +E
Sbjct: 1860 -----QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVE 1914
Query: 1397 LQ---------MFQGNCDQVESWMVARE---NSLRSDDKSSLDSLEALMKKRDDLDKAIT 1444
++ +G + +W+ + NS S+ + +DSL +++ +DL + +
Sbjct: 1915 IEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMA 1974
Query: 1445 AQEGKIT----DLEHF----AESLIADEHYAKEEIATRLQR----VLDRWKALKAQLIDE 1492
++ ++ D++ F A+ L ++ + LQR +L++ A L
Sbjct: 1975 ERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGH 2034
Query: 1493 RTKLGDYANLKQF-------YRDLEELEEWISEMLPTACDE----SYKDATNIQRKYLKH 1541
++ A +K ++ LE+L W+ + + +D + +Q+
Sbjct: 2035 LQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL 2094
Query: 1542 QTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE---AMKEQLEQLKEHWDHLLERTND 1598
+ ++ R+ V+ +E + + A++E+L Q KE ++ L E T
Sbjct: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRV 2154
Query: 1599 KGKKLNEA--SRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAG-----NLLKKHQL 1651
K+L EA S Q+ + + + + A+ D + S+G NL QL
Sbjct: 2155 AQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQL 2214
Query: 1652 ----LEREMLAREDALKDLNTLAEDLLSSGTF---NVDQIVKKKDNVNKRFLNVQELAAA 1704
LE+ L D +N E L +++ ++ N + Q
Sbjct: 2215 SGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ 2274
Query: 1705 HHE---------------KLKEAYA-------------------LFQFFQDLDDEESWIE 1730
H +LKE Y+ L +F QD + ESW+E
Sbjct: 2275 HGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLE 2334
Query: 1731 EKLIRVSSQDYGRDL-QGVQNLLKKHKRLEGELVAHEPAI-------QNVLDMAEKLKDK 1782
+ + G + + +LLK+ ++++H+ + Q VLDM K+
Sbjct: 2335 RSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE- 2393
Query: 1783 AAVGQEEIQL------RLAQFVEHWEKLKELAKARGLKLEESL-EYLQFMQNAEEEEAWI 1835
G+E ++ +L E + L G L L +Y QF +A+ +AW+
Sbjct: 2394 ---GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWM 2450
Query: 1836 NEKNALAVRGDCGDTLAATQSLLMKHEA----LENDFAVHETRVQNVCAQGEDILNKVLQ 1891
A V DT+A+ +L + A L+ + A H+ V+ + DI+ +
Sbjct: 2451 QACEA-NVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGE 2509
Query: 1892 EESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYA-FQEFNWKADVVEAWIADKETS 1950
++ + +++ SL+ ++A L+ A Q + + I + E +
Sbjct: 2510 PAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQN 2569
Query: 1951 LKTNG-NGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAI-EE 2008
L+ + G LA L + Q+ L ++ + + + + A+ +
Sbjct: 2570 LEGKQVSSLSSGVIQEALATNMKLKQDIAR-QKSSLEATREMVTRFMETADSTTAAVLQG 2628
Query: 2009 RYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLS- 2067
+ A + +R+EQL ++ L+K LP + F H + L + E L+
Sbjct: 2629 KLAEVSQRFEQLC-LQQQEKESSLKKLLPQAEM------FEHLSGKLQQFMENKSRMLAS 2681
Query: 2068 --EPVHCVS--LNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLT 2123
+P ++ +I++L + ED Q + L L ++ + G
Sbjct: 2682 GNQPDQDITHFFQQIQELNLEMED-------QQENLDTLEHLVTELSSCGFALDLCQHQD 2734
Query: 2124 -VEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLD 2182
V+ L + + L ++ERE++ + E EF + TF +W+ ET
Sbjct: 2735 RVQNLRKDFTELQKTVKEREKDASSCQ-------EQLDEFRKLVRTFQKWLKETEGSIPP 2787
Query: 2183 GSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDAL--------------I 2228
LE Q+E K + + + +I G +LE+ + I
Sbjct: 2788 TETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSI 2847
Query: 2229 LDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLT 2288
L S++G + L + ++ + + GV E + I +E
Sbjct: 2848 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEE--- 2904
Query: 2289 GRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKG---YVSLEDYTAFLID 2345
HKE S L+ L E + + K +DA+ K E AFL +
Sbjct: 2905 ---VHKEANSVLQWL----------ESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAE 2951
Query: 2346 KESENIKSSDEIENAFQALA 2365
E ++S +I+ +ALA
Sbjct: 2952 LE----QNSPKIQKVKEALA 2967
Score = 39.3 bits (90), Expect = 0.047
Identities = 57/294 (19%), Positives = 123/294 (41%), Gaps = 39/294 (13%)
Query: 9 VVESSGPKVLETAEE----IQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDAD 63
V++ SG +++E + + ++ + QE+ TR+ + + + +LE + +VF+
Sbjct: 5264 VLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVH 5323
Query: 64 DLGKWIMEKVNILTDKSY--EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTM 121
L +W+ E L + +D +Q H+ +V+ K ++ E +
Sbjct: 5324 MLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAV 5383
Query: 122 GHSAHEETKAH-IEELRHLWDLLLELTLEKGDQLLRAL-KFQQYVQECADILEWIGDKEA 179
H T H I +R ++ +L + +L AL + + ++L WI E
Sbjct: 5384 CHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAET 5443
Query: 180 IATSVE---LGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQ-YANECAEENH------ 229
+ + ++ +R + L + + F E+ K+ V V + Y + E H
Sbjct: 5444 TLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEK 5503
Query: 230 --------------PDLPLIQSKQ------NEVNAAWERLRGLALQRQKALSNA 263
P +P++ + N+++A W+++ LAL+RQ+ L++A
Sbjct: 5504 SRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDA 5557
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 191 bits (484), Expect = 1e-47
Identities = 444/2405 (18%), Positives = 942/2405 (39%), Gaps = 222/2405 (9%)
Query: 19 ETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIMEK---VN 74
+ AE ++ ++E+ +R++ E R ++LE+S HL F+ L W+MEK +
Sbjct: 2475 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMG 2534
Query: 75 ILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIE 134
+L S DP + + Q+ Q + E + + + +L + + T T +
Sbjct: 2535 VLGPLSI-DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQK 2593
Query: 135 ELRHLWDLLLELTLEKGDQ-------LLRALKFQQYVQECADILEWIGDK----EAIATS 183
EL+ + +ELT + + ++++ ++Q+ +Q+ ++ + +G + AI+T
Sbjct: 2594 ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQ 2653
Query: 184 VE-LGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEV 242
E + + E T + E E+ + E++ E ++ ++ + V
Sbjct: 2654 PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE-----LKKRLETV 2708
Query: 243 NAAWERLRGLALQRQKALSNA-ANLQRFKRDVTEAIQWIKEKEPVLTSE-DYGKDLVASE 300
+ L LA R L A A+ Q+F++ E W+ +K+ L +
Sbjct: 2709 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 2768
Query: 301 GLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHP--SDAPQIQEMKEDLVSSWEHIRAL 358
++ +++L S + + A+ E L LS P + +Q +L + WE +
Sbjct: 2769 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 2828
Query: 359 ATSRYEKLQ-ATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKH 417
R +L+ ++ ++L W+ + A ++ + D E L R + +
Sbjct: 2829 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 2888
Query: 418 EIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLD 477
E++ + + L+N++ D +R++ ++ N A+ E + E+
Sbjct: 2889 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQ 2948
Query: 478 -FHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVD 536
F + ++ + + LE D S + L+K +E A E ++ +
Sbjct: 2949 RLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLR 3008
Query: 537 KTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKN 596
L+ D S+ + + +A+++ L K + L+ + + ++
Sbjct: 3009 NFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE 3068
Query: 597 WINKKKKLADDEDY-----KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMI-EG 650
++ L D+ D +D +L+S+++ ++F ++ V K +E + + M+ E
Sbjct: 3069 MFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEE 3128
Query: 651 GHYASDNVTTRLSEVASLWEELLEATKQKGTQLH-------EANQQLQFENNAEDLQRWL 703
G + L + +L E K + QL + ++L+ N+A
Sbjct: 3129 GTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEA 3188
Query: 704 EDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHP---- 759
E ++W V +E E+ N+ L +++QVD L +G
Sbjct: 3189 EALQWVVGTE------VEIINQQ-----LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQS 3237
Query: 760 -----DSKDIRARQESLVCRFEALKEPLATRKKKLLD-LLHLQLICRDTEDEEAWIQETE 813
D + + E + R+ L + +A R +L + LLH E +W+ +TE
Sbjct: 3238 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3297
Query: 814 -------PSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFA 866
P + + K I +KLL R +L++ + + + G ++ + A
Sbjct: 3298 ELIANQKPPSAEYKVVKAQIQEQKLLQR---LLDD---RKATVDMLQAEGGRIAQSAELA 3351
Query: 867 -AEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIRE-----KEP 920
E + +++SL L ++AA RQ LE + + HE I + ++
Sbjct: 3352 DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAK---QFHETAEPISDFLSVTEKK 3408
Query: 921 IVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQ 980
+ ++ G + +H+A D+ + + + + +GV E+
Sbjct: 3409 LANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEK 3468
Query: 981 ----------------RVMALYDFQARSPREVTMKKGDVLTLLSSIN------------K 1012
R AL D + R + +VL L+ + +
Sbjct: 3469 IDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQ 3528
Query: 1013 DWWKVEAADHQGIVPAVYVRRLAHDEF-----PMLPQRRREEPGNITQRQEQIENQYRSL 1067
D + ADH + + R+ D+ +L Q EE I ++ + I+ +Y +
Sbjct: 3529 DVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADI 3588
Query: 1068 LDRAEERRRRLLQRYN---EFLLAYEAGDMLEWIQEKKAE--------NTGVELDDVWEL 1116
+ + R L Q +F YE ++ W++E + E TG ++ +
Sbjct: 3589 TVTSSKALRTLEQARQLATKFQSTYE--ELTGWLREVEEELATSGGQSPTGEQIPQFQQR 3646
Query: 1117 QKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQ-----IRQELNSRWGSLQRL 1171
QK E +K++ + L +N+V+ LL L P A+ + + N ++ +
Sbjct: 3647 QK---ELKKEVMEHRLVLDTVNEVSRALLE---LVPWRAREGLDKLVSDANEQYKLVSDT 3700
Query: 1172 ADEQRQLLGSAHAVEVFHREADDTK----EQIEKKCQALSAADPGSDLFSVQALQRRHEG 1227
++ + +A + +A D + + ++K AL D + Q ++
Sbjct: 3701 IGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK--A 3758
Query: 1228 FERDLVPLGDKVT-ILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLN 1286
F D++ D + + +E + LQ + L + +E + +R L
Sbjct: 3759 FSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLE 3818
Query: 1287 EAQKFY-LFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEA--- 1342
AQ F +L WI +++ +L E L ++ +E R E+ A
Sbjct: 3819 RAQVLVNQFWETYEELSPWIEETRALIA--QLPSPAIDHEQLRQQQEEMRQLRESIAEHK 3876
Query: 1343 PTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLE--LQMF 1400
P L +L + +E+K Q + +++ +R LD+ + Q+
Sbjct: 3877 PHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQIT 3936
Query: 1401 QGNCDQVESWMVAREN---SLRSDD--KSSLDSLEALMKKRDDLDKAITAQEGKITDLEH 1455
+ + D++E + EN LR + +D + + + + L+
Sbjct: 3937 EFH-DKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKR 3995
Query: 1456 FAESLI-----ADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANL-KQFYRDL 1509
E LI AD+ A +EI +L +++ W+ +KA+ + K D L ++F+ D+
Sbjct: 3996 RGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDM 4055
Query: 1510 EELEEWISEMLPTACDESYK--DATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIE 1567
L I + D D + I+++ +T E DG E++ + LG LI
Sbjct: 4056 AALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLI- 4114
Query: 1568 CSACDGNEEA-MKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQ-RFNTSIRDFEFWLSE 1625
AC E+ +++ ++++ W++L + ++ +KL +A + ++ +++ WL
Sbjct: 4115 -FACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDN 4173
Query: 1626 AET-LLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQI 1684
L M DL + + L + + + E+ ++ ++ LN E +L T D+
Sbjct: 4174 TVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRD 4233
Query: 1685 VKKKDNVNKRFL--NVQELAAAHHEKLKEAY-ALFQFFQDLDDEESWIE--EKLIRVSSQ 1739
+ ++ + L N+ E A KL+ A AL QF L++ SW+ E+L+
Sbjct: 4234 IIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRP 4293
Query: 1740 DYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMA-EKLKDKAAVGQEEIQLRLAQFV 1798
G D + ++ L KH L+ +++AH+ ++ V E L+ A ++ RL
Sbjct: 4294 ISG-DPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMN 4352
Query: 1799 EHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINE----KNALAVRGDCGDTLAAT 1854
+ WE + + + R +L+ +L+ Q + E E ++ E ++ L+ G
Sbjct: 4353 QCWESVLQKTEEREQQLQSTLQQAQGFHS--EIEDFLLELTRMESQLSASKPTGGLPETA 4410
Query: 1855 QSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLA 1914
+ L H L + E + +G +L + + + L +K ++
Sbjct: 4411 REQLDTHMELYSQLKAKEETYNQLLDKGRLMLLS-RDDSGSGSKTEQSVALLEQKWHVVS 4469
Query: 1915 KAIAAWKLQLEDDYAFQ-EFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTL 1973
+ K +LE+ EF W+ E SL + + + + ++ +
Sbjct: 4470 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV 4529
Query: 1974 DASLQSFQQERLPEITDLKDKL-ISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLL 2032
A+ + ++++ E+ ++L +Q I+ ++ RWE++++ S +
Sbjct: 4530 FANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRS-------I 4582
Query: 2033 EKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQ-KDHEDFLAS 2091
E+ L A +F L +W E E +L + + + +LQ H++F +
Sbjct: 4583 ERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKT 4642
Query: 2092 LARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEAR 2151
L Q + + + +K L E ++ L ++ ++ + K R
Sbjct: 4643 LGGKQPVYDTTIRTGRALKE--------KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
Query: 2152 QVKNFE---MCQEFEQNASTFLQWILETRAYFL-DGSLLKETGTLESQLEANKRKQKE-- 2205
Q K E +F + W+ + D + + + + ++A+K QKE
Sbjct: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG 4754
Query: 2206 -----IQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQI 2260
+Q +KR ++++ N D +K L+ +WD + +L + Q LEQ +
Sbjct: 4755 KRTGTVQVLKRSGRELIE---NSRDDTTW-VKGQLQELSTRWDTVCKLSVSKQSRLEQAL 4810
Query: 2261 QAKDI 2265
+ ++
Sbjct: 4811 KQAEV 4815
Score = 187 bits (474), Expect = 1e-46
Identities = 412/2034 (20%), Positives = 813/2034 (39%), Gaps = 257/2034 (12%)
Query: 22 EEIQERR---QEVLTRYQSFKERVAERGQKLEDSYH-LQVFKRDADDLGKWIMEKVNILT 77
EE+Q + +E+ R + F+E +K+E + H L++F D LG N+
Sbjct: 2934 EELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF----DALGSQACSNKNL-- 2987
Query: 78 DKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELR 137
++ + + Q+LE +V L + + H+ A E L
Sbjct: 2988 -------EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLE 3040
Query: 138 -----HLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWER 192
+ +++E LE Q + ++ + AD+ + + AI G D
Sbjct: 3041 VKQRVNSGCVMMENKLEGIGQF--HCRVREMFSQLADLDDELDGMGAI------GRD--- 3089
Query: 193 TEVLHKKFEDFQVELVAKEGRVVEVNQYANECA----EENHPDLPLIQSKQNEVNAAWER 248
T+ L + ED ++ L +++ EC EE DL ++ + +N +
Sbjct: 3090 TDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGK 3149
Query: 249 L--RGLALQRQKALSNAANLQRFKRDV------------TEAIQWIKEKEPVLTSEDYGK 294
L RG A Q Q L+ ++ F R + EA+QW+ E + ++
Sbjct: 3150 LTERGKARQEQLELT-LGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ--- 3205
Query: 295 DLVASEGLFHSHK--GLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSW 352
+A +F + L+ L ++ + L A K D ++ E++ + W
Sbjct: 3206 --LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK-----DCDVQGLEHDMEEINARW 3258
Query: 353 EHIRALATSRYEKLQATYWY-HRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411
+ R +LQ + +F + L W+ + I + P+ A +V+ +
Sbjct: 3259 NTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPS--AEYKVVKAQ 3316
Query: 412 HQQHKHEIDSYDDRFQSAD----ETGQDLVNANHEASDEVREKMEILDNNWTALLELWDE 467
Q+ K DDR + D E G+ +A +++ ++E L++ WT LL
Sbjct: 3317 IQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAA 3376
Query: 468 RHRQYEQCLDF-HLFYRDSEQVDSWMSRQEAFLEN-EDLGNSLGSAEALLQKHEDFEEAF 525
R +Q E L F+ +E + ++S E L N E +G + + +H+ EE
Sbjct: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3436
Query: 526 TAQEEKIITVDKTATKLIGDDHYDSENIKAIR-DGLLARRDALREKAATRRRLLKESLLL 584
+ K L + + + + D L AR ++++ + LL ++L
Sbjct: 3437 ENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSN 3496
Query: 585 QKLY-EDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKE----LAVNKTQLEN 639
+L+ ED ++ NW+ + + KD KQ V ++ LA+N+ ++ N
Sbjct: 3497 ARLFGEDEVEVLNWLAEVEDKLSSVFVKDF--------KQDVLHRQHADHLALNE-EIVN 3547
Query: 640 IQKTGQEMIEGGHYASDNVTTRLSEVASLWEEL---------LEATKQKGTQLHEANQQL 690
+K + I+ G T EV + E+L + T K + E +QL
Sbjct: 3548 RKKNVDQAIKNGQALLKQTTGE--EVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL 3605
Query: 691 --QFENNAEDLQRWLEDVEWQVTSED----YGKGLAEVQNRLRKHGLLESAVAARQDQVD 744
+F++ E+L WL +VE ++ + G+ + + Q R ++ L+ V + +D
Sbjct: 3606 ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE---LKKEVMEHRLVLD 3662
Query: 745 ILTDLAAYFEEIGHPDSKDIRARQ--ESLVC----RFEALKEPLATRKKKLLDLLHLQLI 798
+ +++ E+ RAR+ + LV +++ + + + R ++ +
Sbjct: 3663 TVNEVSRALLEL-----VPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 3717
Query: 799 CRDTEDEE-AWIQET------------EPSATSTYLGKDLIASKKLLNRHRVILENIASH 845
D E AW+ ET E T+ L S ++ RH+ ++ + SH
Sbjct: 3718 YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDII-RHKDSMDELFSH 3776
Query: 846 EPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE-ANVQFQQY 904
I K V + + +SL Q E++ + R LE A V Q+
Sbjct: 3777 RSEIFGTCGEEQKTV---------LQEKTESLIQQYEAISLLNSERYARLERAQVLVNQF 3827
Query: 905 LADLHEAETWIREKE--------PIVDNTNYGADEEAAGAL---LKKHEAFLLDLNSFGD 953
E WI E P +D+ +E L + +H+ + L G
Sbjct: 3828 WETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 3887
Query: 954 SMKALRNQANACQQQQAAPVEGVAGE------QRVMALYDFQARSPR--EVTMKKGDVLT 1005
+K L + +++ E + + QR +AL + ++S + E K +L
Sbjct: 3888 QLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLE 3947
Query: 1006 LLSSINK----------DWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGN--- 1052
L +++ + K+ V + +L F L +R E G
Sbjct: 3948 TLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKL-QPSFEALKRRGEELIGRSQG 4006
Query: 1053 ---------ITQRQEQIENQYRSLLDRAEERRRR---LLQRYNEFLLAYEAGDMLEWIQE 1100
I + +Q+ + + RAEER + +L+ +F Y+ +L I++
Sbjct: 4007 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFW--YDMAALLTTIKD 4064
Query: 1101 KK-----AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLT--PE 1153
+ E+ G++ + + + + +++ + L I + DL+F T PE
Sbjct: 4065 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4124
Query: 1154 GAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTK-EQIEKKCQALSAADP- 1211
+ E+N+ W +L + E+ + L A V +++ + ++ L P
Sbjct: 4125 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4184
Query: 1212 GSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATE-DLQRQKM-ELNE 1269
G+DL +V+ + F+ ++ ++ L E + + D T+ D+ R+ + EL
Sbjct: 4185 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4244
Query: 1270 AWEDLQGRTKDRKESLNEAQ-KFYLFLSKARDLQNWISSIGGMVSSQE-LAEDLTGIEIL 1327
WE+L + R+ L A F +L +W++ ++ +Q ++ D IE+
Sbjct: 4245 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4304
Query: 1328 LERHQEHRADMEAEAPTFQALEDFSAELIDS--GHHASPEIEKKLQAVKLERDDLEKAWE 1385
L +H + D+ A T + + EL++S G AS + +L+A+ + + + E
Sbjct: 4305 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDAS-SLRSRLEAMNQCWESVLQKTE 4363
Query: 1386 KRKKILDQCLELQMFQGNCDQVESWMV--ARENSLRSDDKSSLDSLEALMKKRD---DLD 1440
+R++ L L Q QG ++E +++ R S S K + E ++ D +L
Sbjct: 4364 EREQQLQSTL--QQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY 4421
Query: 1441 KAITAQEGKITDLEHFAESLIA--DEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGD 1498
+ A+E L ++ D+ + + + + +W + +++ + ++KL +
Sbjct: 4422 SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4481
Query: 1499 YANLK-QFYRDLEELEEWISEMLPTACDESYKDAT-------NIQRKYLKHQTFAHEVDG 1550
NL +F L+E W+ T ++S A+ + + +H+ FA+EV+
Sbjct: 4482 ALNLATEFQNSLQEFINWL-----TLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 4536
Query: 1551 RSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEA-SRQ 1609
+Q+ + GN L S + +K L ++ W+ +++R+ ++G+ L++A R
Sbjct: 4537 HRDQIIELDQTGNQLKFLSQKQ-DVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA 4595
Query: 1610 QRFNTSIRDFEFWLSEAETLLAMK-DQARDLASAGNLLKKHQLLEREMLARED------- 1661
++F+ + + WL +AE+ L + + + D L KH+ ++ + ++
Sbjct: 4596 KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 4655
Query: 1662 ---ALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF-Q 1717
ALK+ L ED F + ++ K D V + + Q KL+EA Q
Sbjct: 4656 TGRALKEKTLLPEDSQKLDNF-LGEVRDKWDTVCGKSVERQH-------KLEEALLFSGQ 4707
Query: 1718 FFQDLDDEESW---IEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLD 1774
F L W +E +L Q DL V NL+ HK + EL +Q +
Sbjct: 4708 FMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKR 4765
Query: 1775 MAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQ-FMQNAEEEEA 1833
+L + + ++ +L + W+ + +L+ ++ +LE++L+ + F
Sbjct: 4766 SGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 4825
Query: 1834 WINE-KNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDIL 1886
W++E + L RG D A QSL+ H+ V + A GE IL
Sbjct: 4826 WLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVIL 4879
Score = 184 bits (466), Expect = 1e-45
Identities = 497/2678 (18%), Positives = 1023/2678 (38%), Gaps = 406/2678 (15%)
Query: 16 KVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYH-LQVFKRDADDLGKWIMEKVN 74
++L +++ I + ++ TRY + + + + D+ L+ ++ ++ + +EKV
Sbjct: 1373 RMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVK 1432
Query: 75 IL---------------TDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERF 119
L T ++ T+I+ + Q L E+ TK +SE KT +
Sbjct: 1433 ELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFL 1492
Query: 120 TM-GHSAHEETKAHI-EELRHLWDLLLELTLEKGDQLL------------RALKFQQYV- 164
GH E+ K I E+L L +L +QL + L+ QQ
Sbjct: 1493 AKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTC 1552
Query: 165 -QECADILEWIGDKEAIATSVELGEDWERTEVLHKK---FEDFQVELVAKEGRVVEVNQY 220
Q+ D+ W+G E + + L K +D Q ++ + V +
Sbjct: 1553 HQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKD 1612
Query: 221 ANECAEENHP-----DLPLIQSKQNEVNAAWERLRG--------------LALQRQKALS 261
EEN +L ++ K ++ +E L+ ALQ++ S
Sbjct: 1613 IEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKS 1672
Query: 262 NAAN-LQRFKRDVTEAIQWIK------------------------EKEPVLTSEDYGKDL 296
AA L K+ + + W+ EK + T++ Y
Sbjct: 1673 KAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGY---- 1728
Query: 297 VASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSD-----------APQIQEMK 345
G+ + + L++ +M + +EL ++ + L+ S P+ Q+M
Sbjct: 1729 ---MGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQML 1785
Query: 346 EDLVSSW--EHIRALATSRYEKLQATYWY---HRFSSDFDELSGWMNEKTAAINADELPT 400
+ + ++ +LA S E Q +F D E W+ + EL
Sbjct: 1786 QQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLER-----SEKELEN 1840
Query: 401 DVAGGEV------LLDRHQQHKHEIDSYDDRFQSADETGQDLVNANH---------EASD 445
GG LL R ++ S+ + +GQ +++ + E +
Sbjct: 1841 MHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGN 1900
Query: 446 EVREKMEILDNNWTALLELWDERHRQYEQCL-DFHLFYRDSEQVDSWMSRQEAFLENEDL 504
V++K++ +TAL L +H F ++ + +WM EA +E L
Sbjct: 1901 LVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKL-L 1959
Query: 505 GNSLGSAEALLQKH----EDFEEAFTAQE---EKIITVDKTATKLIGDDHYDSENIKAIR 557
+++ S +LQ+ + +E + EK+ V + ++ G+ D +++
Sbjct: 1960 SDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETT 2019
Query: 558 DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLK 617
D +L+ +L A R LL++++ + ++S L++ + ++ + + K + +L
Sbjct: 2020 DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES--LESLLQSIGEVEQNLEGKQVSSLS 2077
Query: 618 SRVQKQQV-----FEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTT-----RLSEVAS 667
S V ++ + ++++A K+ LE +EM+ +D+ T +L+EV+
Sbjct: 2078 SGVIQEALATNMKLKQDIARQKSSLE----ATREMVTRFMETADSTTAAVLQGKLAEVSQ 2133
Query: 668 LWEELLEATKQKGTQLHEANQQLQ-FENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRL 726
+E+L ++K + L + Q + FE+ + LQ+++E+ + S + ++ +
Sbjct: 2134 RFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPD--QDITHFF 2191
Query: 727 RKHGLLESAVAARQDQVDILTDLAAYFEEIGHP-DSKDIRARQESLVCRFEALKEPLATR 785
++ L + +Q+ +D L L G D + R ++L F L++ + R
Sbjct: 2192 QQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKER 2251
Query: 786 KKKLLDLLHLQLICRDTEDE--------EAWIQETEPSATSTYLGKDLIASKKLLNRHRV 837
+K C++ DE + W++ETE S T +K + +
Sbjct: 2252 EKDASS-------CQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKS 2304
Query: 838 ILENIASHEPRIQEITERGNKMVE----------------------------EGHFAAED 869
+L++ AS ++EI +G + G+ +D
Sbjct: 2305 LLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKD 2364
Query: 870 ---VASRVKSLNQNMESLRARAARRQNDLEANV-QFQQYLADLHEAETWIREKEPI---V 922
+ + +N E L RQ L+A + + ++ + + W+ KE + +
Sbjct: 2365 LTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSM 2424
Query: 923 DNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRN---------------------Q 961
D + E A + ++AFL +L ++ ++ Q
Sbjct: 2425 DAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQ 2484
Query: 962 ANACQQQQAAPVEGVAGEQRV------MALYDFQARSPREVTMKKGDVLTLLS--SINKD 1013
+ + A VA ++++ +A + R M+K ++ +L SI+ +
Sbjct: 2485 EELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPN 2544
Query: 1014 WWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEE 1073
+ Q ++ RR H++ Q PG+++ Q++ + +S+ + E
Sbjct: 2545 MLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVE 2604
Query: 1074 RRRRLLQRYNE----FLLAYEAGDMLEWIQEK-KAENTGVELDDVWELQ--------KKF 1120
+L R ++ + + + ++L+ + EK +A + + Q ++
Sbjct: 2605 LTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEET 2664
Query: 1121 DEFQKDLNTNEPRLRDINKVADD---LLFEGLLTPEGAQIRQELNSRWGSLQRL----AD 1173
E + DL + +++ + D+ L+ E L E +++ L + LQ L AD
Sbjct: 2665 SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE---LKKRLETVALPLQGLEDLAAD 2721
Query: 1174 EQRQLLGSAHAVEVFHREADDTKEQI-EKKCQALSAADPGSDLFSVQALQRRHEGFERDL 1232
+L + + + F + D+ + + +K+ Q + L +Q+ + +E F++ L
Sbjct: 2722 RINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSL 2781
Query: 1233 VPLGDKVTILGETAERLSESHPDATE--DLQRQKMELNEAWEDLQGRTKDRKESLNEA-Q 1289
++ E L S P E LQ Q +EL WE+L +T DR+ L + Q
Sbjct: 2782 NQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQ 2841
Query: 1290 KFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALE 1349
K + DL WI +S + D +E L R + ++E + L
Sbjct: 2842 KAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILN 2901
Query: 1350 DFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLE-LQMFQGNCDQVE 1408
+ LI+S I + + D + + + + L++ + L+ FQ + +E
Sbjct: 2902 SAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIE 2961
Query: 1409 SWMVARENSLRSDDK--SSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLI----- 1461
+ ++ L D S S + L K R + + A E ++ L +F + L+
Sbjct: 2962 KKVEGAKHQLEIFDALGSQACSNKNLEKLRAQ-QEVLQALEPQVDYLRNFTQGLVEDAPD 3020
Query: 1462 -ADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGD----YANLKQFYRDLEELEEWI 1516
+D + Q L+ + + + + KL + +++ + L +L++ +
Sbjct: 3021 GSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDEL 3080
Query: 1517 SEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE 1576
M +D ++Q + + F +++ V+ L E EE
Sbjct: 3081 DGMGAIG-----RDTDSLQSQIEDVRLFLNKIH--------VLKLDIEASEAECRHMLEE 3127
Query: 1577 -------AMKEQLEQLKEHWDHLLERTNDKGKKLN-EASRQQRFNTSIRDFEFWLSEAET 1628
+K +LE L + L ER + ++L R + F ++ L++A T
Sbjct: 3128 EGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG----LNDATT 3183
Query: 1629 LLAMKDQARDLASAGNLLKKHQLLEREMLAREDA------LKDLNTLAEDLLSSG--TFN 1680
+ + + + QL + +M +E L+ +N L + L+ S +
Sbjct: 3184 AAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCD 3243
Query: 1681 VDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQD-LDDEESWI--EEKLIRVS 1737
V + + +N R+ + + A +L+EA FQD L+ SW+ E+LI +
Sbjct: 3244 VQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-AN 3302
Query: 1738 SQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVG-QEEIQLRLAQ 1796
+ + + V+ +++ K L+ L + + + ++ A + +E+I +L
Sbjct: 3303 QKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLES 3362
Query: 1797 FVEHWEKLKELAKARGLKLEESLEYL-QFMQNAEEEEAWIN-EKNALAVRGDCGDTLAAT 1854
W +L A AR +LE+ L QF + AE +++ + LA G A
Sbjct: 3363 LESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKI 3422
Query: 1855 QSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALN------- 1907
Q +++H+ALE D H T V G+ + + L ++ +S KI++L
Sbjct: 3423 QQQIIRHKALEEDIENHATDVHQAVKIGQSLSS--LTSPAEQGVLSEKIDSLQARYSEIQ 3480
Query: 1908 ----EKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVE----AWIADKETSLKTNGNGAD 1959
K L +A++ +L ED+ + NW A+V + ++ D + + +
Sbjct: 3481 DRCCRKAALLDQALSNARLFGEDE--VEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADH 3538
Query: 1960 LGDFLTLLAKQDTLDASLQSFQ----QERLPEITDLKDKLISAQHNQSKAIEERYAALLK 2015
L ++ ++ +D ++++ Q Q E+ +++KL I+ RYA +
Sbjct: 3539 LALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKL--------DGIKTRYADI-- 3588
Query: 2016 RWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENL-SEPVHCVS 2074
V K L L++A L +F L W ++EE L + +
Sbjct: 3589 ---------TVTSSKALR---TLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPT 3636
Query: 2075 LNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLER----- 2129
+I Q Q+ ++ + + + E+ + + L VP W E L++
Sbjct: 3637 GEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLEL-VP-----WRAREGLDKLVSDA 3690
Query: 2130 --TWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLD-GSLL 2186
+K +SD I +R E+ R Q++EQ A L W+ ET+ + G +
Sbjct: 3691 NEQYKLVSDTIGQRVDEIDAAIQRS-------QQYEQAADAELAWVAETKRKLMALGPIR 3743
Query: 2187 KETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL------EDALILDIKYSTIGLAQ 2240
E +QL+ K +I K + ++ + E +L K T L Q
Sbjct: 3744 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEK--TESLIQ 3801
Query: 2241 QWDQLYQLGLRMQHNLEQ-QIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSC 2299
Q++ + L LE+ Q+ EE + + + H++ R
Sbjct: 3802 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQ 3861
Query: 2300 LRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIEN 2359
+ + EH+P +K L + P K N + + +E
Sbjct: 3862 QEEMRQLRESIA--EHKPHIDKLL-KIGPQLK----------------ELNPEEGEMVEE 3902
Query: 2360 AFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQYMD 2397
+Q + I +E ++AL ++ +T + ++ D
Sbjct: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 3940
Score = 173 bits (439), Expect = 2e-42
Identities = 426/2329 (18%), Positives = 930/2329 (39%), Gaps = 168/2329 (7%)
Query: 19 ETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTD 78
+ +E+Q Q+ + R ++ Q + S Q +D + + + +++++ +
Sbjct: 2590 QVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSA 2649
Query: 79 KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAH--EETKAHIEEL 136
S + P ++ + ++ + ++++ + E + +E + + +E K +E +
Sbjct: 2650 ISTQ-PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV 2708
Query: 137 RHLWDLLLELTLEKGDQLLRALKFQQYVQECADILE-WIGDKEAI-ATSVELGEDWERTE 194
L +L ++ ++L AL Q Q+ D L W+ DK++ A + + ER +
Sbjct: 2709 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 2768
Query: 195 VLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHP--DLPLIQSKQNEVNAAWERLRGL 252
++ E+FQ L G + P + +Q++ E+ WE L
Sbjct: 2769 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 2828
Query: 253 ALQRQKALSNAAN-LQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLER 311
RQ L + Q+++ V + + WI++ + ++ D V E K +
Sbjct: 2829 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 2888
Query: 312 NLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQA-TY 370
+ ++ L + A+ L S +D I++ K + + + + ++ L+ T
Sbjct: 2889 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQ 2948
Query: 371 WYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSAD 430
F F + + + + A L++ + + + + + +
Sbjct: 2949 RLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLR 3008
Query: 431 ETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDS 490
Q LV + SD ++L A E + + R C+ + E +
Sbjct: 3009 NFTQGLVEDAPDGSDA----SQLLHQAEVAQQEFLEVKQRVNSGCV---MMENKLEGIGQ 3061
Query: 491 WMSR-QEAFLENEDLGNSLGSAEALLQKHEDFEEAFT-----AQEEKIITVDKTATK--- 541
+ R +E F + DL + L A+ + + + + ++ +D A++
Sbjct: 3062 FHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAEC 3121
Query: 542 ---LIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWI 598
L + D +K + L + L E+ R+ L+ L L ++ + LK +
Sbjct: 3122 RHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLE--LTLGRVEDFYRKLKG-L 3178
Query: 599 NKKKKLADDEDY------KDIQNLKSRVQKQQVFEKE-LAVNKTQLENIQKTGQEMIEGG 651
N A++ + +++ + ++ ++F+KE + + +L+ + GQ +I+
Sbjct: 3179 NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSA 3238
Query: 652 HYASD--NVTTRLSEVASLWEELLEATKQKGTQLHEANQQL-QFENNAEDLQRWLEDVEW 708
D + + E+ + W L + Q+ QL EA +F++ E L WL D E
Sbjct: 3239 GKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEE 3298
Query: 709 QVTSEDYGKGLAEV-QNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGH-PDSKDIRA 766
+ ++ +V + ++++ LL+ + R+ VD+L + D + I
Sbjct: 3299 LIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITG 3358
Query: 767 RQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT-EDEEAWIQETEPS-ATSTYLGKD 824
+ ESL R+ L A R+K+L D+L L +T E ++ TE A S +G
Sbjct: 3359 QLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQ 3418
Query: 825 LIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVAS-RVKSLNQNMES 883
++ + RH+ + E+I +H + + + G + A + V S ++ SL
Sbjct: 3419 TAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSE 3478
Query: 884 LRARAARRQNDLEANVQFQQYLA-DLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHE 942
++ R R+ L+ + + D E W+ E E D + ++ +L +
Sbjct: 3479 IQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE---DKLSSVFVKDFKQDVLHRQH 3535
Query: 943 AFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPR--EVTMKK 1000
A L LN + + +N A + QA ++ GE+ ++ R ++T+
Sbjct: 3536 ADHLALNE--EIVNRKKNVDQAIKNGQAL-LKQTTGEEVLLIQEKLDGIKTRYADITVTS 3592
Query: 1001 GDVLTLLSSINKDWWKVEAADHQ--GIVPAVYVRRLAH-------DEFPMLPQRRREEPG 1051
L L + K ++ + G + V ++ P QR++E
Sbjct: 3593 SKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKK 3652
Query: 1052 NITQRQ---EQIENQYRSLLD----RAEERRRRLLQRYNEF--LLAYEAGDMLEWIQ--- 1099
+ + + + + R+LL+ RA E +L+ NE L++ G ++ I
Sbjct: 3653 EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI 3712
Query: 1100 ---EKKAENTGVELDDVWELQKKF----------DEFQKDLNTNEPRLRDINKVAD--DL 1144
++ + EL V E ++K D+ L + DI + D D
Sbjct: 3713 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 3772
Query: 1145 LFE------GLLTPEGAQIRQE----LNSRWGSLQRLADEQRQLLGSAHA-VEVFHREAD 1193
LF G E + QE L ++ ++ L E+ L A V F +
Sbjct: 3773 LFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYE 3832
Query: 1194 DTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFE-RDLV----PLGDKVTILGETAER 1248
+ IE+ +AL A P + Q Q++ E + R+ + P DK+ +G +
Sbjct: 3833 ELSPWIEET-RALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE 3891
Query: 1249 LSESHPDATED-LQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISS 1307
L+ + E+ Q+ + + E+++ R E+++++ + F K + + +
Sbjct: 3892 LNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLEN 3951
Query: 1308 IGGMVSSQELAE-DLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHA---- 1362
+ + L ++ I + ++ ++E P+F+AL+ ELI A
Sbjct: 3952 LSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDL 4011
Query: 1363 -SPEIEKKLQAVKLERDDLEKAWEKRK-KILDQCLELQMFQGNCDQVESWMVARENSLRS 1420
+ EI+ KL + +D++ E+R+ K LD + F + + + + ++ +
Sbjct: 4012 AAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHD 4071
Query: 1421 DDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYA-----KEEIATRL 1475
+ +D +++K++ + + I + + + F L AD +A K E+ +
Sbjct: 4072 LESPGIDP--SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4129
Query: 1476 QRVLDRWKALKAQLIDERTKLGDYANLKQFYRD-LEELEEWISEMLPTACDESY--KDAT 1532
+ + W+ L + KL D Y+D L+ + +W+ + C D
Sbjct: 4130 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLN 4189
Query: 1533 NIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHL 1592
++ + + + F EV + ++ + + G +++ + + + + ++E L +LK W++L
Sbjct: 4190 TVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENL 4249
Query: 1593 LERTNDKGKKLNEASRQQ-RFNTSIRDFEFWLSEAETLL-AMKDQARDLASAGNLLKKHQ 1650
E+ + KL A +F ++ + WL+ E LL A + + D L KH
Sbjct: 4250 GEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHH 4309
Query: 1651 LLEREMLAREDALKDLNTLAEDLL-SSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKL 1709
+L+ ++LA + ++ +N +LL SS + + + + +N+ + +V + ++L
Sbjct: 4310 VLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQL 4369
Query: 1710 KEAYALFQ-FFQDLDD---EESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAH 1765
+ Q F +++D E + +E +L +S+ G + + L H L +L A
Sbjct: 4370 QSTLQQAQGFHSEIEDFLLELTRMESQLS--ASKPTGGLPETAREQLDTHMELYSQLKAK 4427
Query: 1766 EPAIQNVLDMAEKL---KDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYL 1822
E +LD + +D + G + Q +A + W + + R KLEE+L
Sbjct: 4428 EETYNQLLDKGRLMLLSRDDSGSGSKTEQ-SVALLEQKWHVVSSKMEERKSKLEEALNLA 4486
Query: 1823 QFMQNAEEEEA-WIN-EKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCA 1880
QN+ +E W+ + +L + L S + +H+ N+ H ++ +
Sbjct: 4487 TEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQ 4546
Query: 1881 QGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYA-FQEFNWKADV 1939
G + K L ++ I + + ++ + + + L+D ++F+
Sbjct: 4547 TGNQL--KFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKK 4604
Query: 1940 VEAWIADKETSLKTNGNGADLGDFLTL-LAKQDTLDASL---QSFQQERLPEITDLKDKL 1995
+ W+ D E+ L + ++ D + L L+K +L Q + LK+K
Sbjct: 4605 LIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKT 4664
Query: 1996 ISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASAL 2055
+ + +Q ++ + +W+ + S +E+Q L++A +F AL
Sbjct: 4665 LLPEDSQK--LDNFLGEVRDKWDTVCGKS-------VERQHKLEEALLFSGQFMDALQAL 4715
Query: 2056 NNWCEKMEENLSE--PVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALG 2113
+W K+E L+E PVH L+ + L H+ F L + + L +++
Sbjct: 4716 VDWLYKVEPQLAEDQPVH-GDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENS 4774
Query: 2114 VPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173
+ + ++ L W + + ++ L++ + + F L+W+
Sbjct: 4775 RDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQA-------LKQAEVFRDTVHMLLEWL 4827
Query: 2174 LET-RAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGD 2221
E + G+L +T L+S ++ +K K+++ + + V +G+
Sbjct: 4828 SEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGE 4876
Score = 156 bits (394), Expect = 3e-37
Identities = 446/2445 (18%), Positives = 939/2445 (38%), Gaps = 294/2445 (12%)
Query: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIMEKVNILTDKSYE 82
+QE +L+ +QS +AER L+ + Q + + L + I E L K
Sbjct: 2015 VQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVS 2074
Query: 83 DPTN--IQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIE----EL 136
++ IQ + L+ ++ +R S LE TRE +A T A ++ E+
Sbjct: 2075 SLSSGVIQEALATNMKLKQDI---ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEV 2131
Query: 137 RHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEA--IATSVELGED----W 190
++ L EK L + L + + + L+ + ++ +A+ + +D +
Sbjct: 2132 SQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFF 2191
Query: 191 ERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLR 250
++ + L+ + ED Q L E V E++ DL Q + + + L+
Sbjct: 2192 QQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL------DLCQHQDRVQNLRKDFTELQ 2245
Query: 251 GLALQRQKALSNAAN-LQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGL 309
+R+K S+ L F++ V +W+KE E + + E K L
Sbjct: 2246 KTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSL 2305
Query: 310 ERNLAVMSDKVKELCAKAEKLT-----LSHPS--------------------------DA 338
+ A V+E+ K L ++ P D
Sbjct: 2306 LDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL 2365
Query: 339 PQIQEMKEDLVSSWEHIRALATSRYEKLQATY-WYHRFSSDFDELSGWMNEKTAAI---N 394
+IQ D+ +E + + R E LQA + + + W+ K + +
Sbjct: 2366 TEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMD 2425
Query: 395 ADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADET--GQDLVNANHEASDEVREKME 452
A PT + + ++ E++ + Q E G + N + ++ ++ E
Sbjct: 2426 AMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQE 2485
Query: 453 ILDNNWTALLELWDERHRQYEQCLDFHLFYRDSE-QVDSWMSRQEAFL------------ 499
L++ W E+ R RQ E+ ++ +E Q+ W+ +E +
Sbjct: 2486 ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNM 2545
Query: 500 ---ENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAI 556
+ + + L EA Q+HE EA + I+T GD + ++
Sbjct: 2546 LNAQKQQVQFMLKEFEARRQQHEQLNEA----AQGILTGP-------GDVSLSTSQVQKE 2594
Query: 557 RDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNL 616
+ + L +K +R + ++++ Y++ L++ K + + + +
Sbjct: 2595 LQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQEL--LQDLSEKVRAVGQRLSVQSAIST 2652
Query: 617 KSRVQKQQVFE-KELAVNKTQLENIQKTGQEMIE------GGHYASDNVTTRLSEVASLW 669
+ KQQ+ E E+ + QL++ K Q + + G Y D + RL VA
Sbjct: 2653 QPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL 2712
Query: 670 EELLEATKQKGTQLHEANQQLQ-FENNAEDLQRWLEDVEWQVTSE-DYGKGLAEVQNRLR 727
+ L + + +L A Q F+ ++L+ WL+D + Q L +Q++L+
Sbjct: 2713 QGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQ 2772
Query: 728 KHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLV---CRFEALKEPLAT 784
++ + ++ +++ + P ++ R Q LV +E L + A
Sbjct: 2773 ENEEFQKSLNQHSGSYEVIVAEGESLL-LSVPPGEEKRTLQNQLVELKNHWEELSKKTAD 2831
Query: 785 RKKKLLDLLH-LQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIA 843
R+ +L D + Q ED WI++ + + + D + + L R + +L +
Sbjct: 2832 RQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVE 2891
Query: 844 SHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQ--- 900
++ + + ++ + + +NQNM+++ + LE Q
Sbjct: 2892 KRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLR 2951
Query: 901 -FQQYLADL--------HEAETWIREKEPIVDNTN---YGADEEAAGAL------LKKHE 942
FQ+ ++ H+ E + N N A +E AL L+
Sbjct: 2952 EFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFT 3011
Query: 943 AFLLDLNSFGDSMKALRNQANACQQQ-----QAAPVEGVAGEQRVMALYDFQARSPREVT 997
L++ G L +QA QQ+ Q V E ++ + F R RE+
Sbjct: 3012 QGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR-VREMF 3070
Query: 998 MKKGDV---LTLLSSINKDWWKVEA--ADHQGIVPAVYV------------RRLAHDE-- 1038
+ D+ L + +I +D +++ D + + ++V R + +E
Sbjct: 3071 SQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGT 3130
Query: 1039 FPMLPQRRREEP-----GNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGD 1093
+L +R E G +T+R + + Q L R E+ R+ L+ N+ A E +
Sbjct: 3131 LDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRK-LKGLNDATTAAEEAE 3189
Query: 1094 MLEWIQEKKAENTGVELDDVWELQKKFDEFQKD-LNTNEPRLRDINKVADDLLFEGLLTP 1152
L+W+ G E++ + + F FQK+ ++ + +L+ +N L +GL+
Sbjct: 3190 ALQWV-------VGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNG-----LGQGLIQS 3237
Query: 1153 EGAQI--------RQELNSRWGSL-----QRLADEQRQLLGSA---HAVEVFHREADDTK 1196
G +E+N+RW +L QR+A Q LL A+E DT+
Sbjct: 3238 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3297
Query: 1197 EQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDA 1256
E I + P ++ V+A + + +R L V +L R+++S A
Sbjct: 3298 ELIANQ------KPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA 3351
Query: 1257 -TEDLQRQKMELNEAWEDLQGRTKDRKESLNE----AQKFYLFLSKARDLQNWIS-SIGG 1310
E + Q L W +L + R++ L + A++F+ A + +++S +
Sbjct: 3352 DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFH---ETAEPISDFLSVTEKK 3408
Query: 1311 MVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEI-EKK 1369
+ +S+ + I+ + RH+ D+E A L A + +K
Sbjct: 3409 LANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEK 3468
Query: 1370 LQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVE--SWMVARENSLRS----DDK 1423
+ +++ +++ ++ +LDQ L G D+VE +W+ E+ L S D K
Sbjct: 3469 IDSLQARYSEIQDRCCRKAALLDQALSNARLFGE-DEVEVLNWLAEVEDKLSSVFVKDFK 3527
Query: 1424 SSL------DSL---EALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATR 1474
+ D L E ++ ++ ++D+AI + + LI ++ + I TR
Sbjct: 3528 QDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK---LDGIKTR 3584
Query: 1475 LQRV-LDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATN 1533
+ + KAL+ +++ +L +F EEL W+ E+ + T
Sbjct: 3585 YADITVTSSKALRT--LEQARQLA-----TKFQSTYEELTGWLREVEEELATSGGQSPTG 3637
Query: 1534 IQ-------RKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLK 1586
Q +K LK + H + + V+ V L+ A +G ++ + + EQ K
Sbjct: 3638 EQIPQFQQRQKELKKEVMEHRL--VLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYK 3695
Query: 1587 EHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAE-TLLAMKDQARDLASAGNL 1645
D + +R ++ + R Q++ + W++E + L+A+ +
Sbjct: 3696 LVSDTIGQRVDEIDAAI---QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ 3752
Query: 1646 LKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQ---IVKKKDNVNKRFLNVQELA 1702
L+ + +++ +D++ +L + ++ GT +Q + +K +++ +++ + L
Sbjct: 3753 LQVQKAFSIDIIRHKDSMDELFSHRSEIF--GTCGEEQKTVLQEKTESLIQQYEAISLLN 3810
Query: 1703 AAHHEKLKEAYALF-QFFQDLDDEESWIEE-KLIRVSSQDYGRDLQGVQNLLKKHKRLEG 1760
+ + +L+ A L QF++ ++ WIEE + + D + ++ ++ ++L
Sbjct: 3811 SERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 3870
Query: 1761 ELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESL- 1819
+ H+P I +L + +LK+ E ++ + + + ++KE + R L L+E++
Sbjct: 3871 SIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVS 3930
Query: 1820 EYLQFMQNAEEEEAWINEKNALAVR-----------GDCGDTLAATQSLLMKHEALENDF 1868
+ Q + ++ E + L+ R + ++ +S ++ E L+ F
Sbjct: 3931 QSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSF 3990
Query: 1869 AVHETRVQNVCAQGEDILNKV--LQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLED 1926
+ R GE+++ + ++ KEI K++ + + +++ D
Sbjct: 3991 EALKRR-------GEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLD 4043
Query: 1927 DYAFQEFNWKADVVEAWIADKETS---LKTNGNGADLGDFLTLLAKQDTLDASLQSFQQE 1983
E W D+ K+T G D + +T+ +E
Sbjct: 4044 VLELAEKFW-YDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEE 4102
Query: 1984 RLPEITDL-KDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE 2042
L I L D + + + + + + WE L + ++ LEK L+ A
Sbjct: 4103 -LEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT----WKERLEK---LEDAM 4154
Query: 2043 DLFVEFAHKASALNNWCEKMEENL-SEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKC 2101
V++ A+ +W + L + P LN ++ + ++F + + Q + +
Sbjct: 4155 QAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEK 4214
Query: 2102 LLELDQQI--KALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMC 2159
L + + KA + L+ W++L + I R+ +L+
Sbjct: 4215 LNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGA-------LLAL 4267
Query: 2160 QEFEQNASTFLQWILETRAYFLDGS--LLKETGTLESQLEANKRKQKEIQAMKRQLTKIV 2217
+F+ + W+ T LD + + +E +L + + ++ A + + +
Sbjct: 4268 GQFQHALEELMSWLTHTEE-LLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326
Query: 2218 DLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQA 2262
G+ L ++ D S + +Q ++ L+ EQQ+Q+
Sbjct: 4327 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQS 4371
Score = 137 bits (346), Expect = 1e-31
Identities = 187/903 (20%), Positives = 385/903 (42%), Gaps = 60/903 (6%)
Query: 23 EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDA-DDLGKWIMEKVNILTDKSY 81
E+++ E+ +++ + ER +KLED+ V +D + W+ V L
Sbjct: 4124 EVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4183
Query: 82 EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHI-----EEL 136
K Q ++ E +V+ + + E+EK + M A +ET I EL
Sbjct: 4184 VGTDLNTVKDQLNEMKEFKVEVYQQQI-EMEKLNHQGELMLKKATDETDRDIIREPLTEL 4242
Query: 137 RHLWDLLLELTLEKGDQLLRAL-KFQQYVQECADILEWIGDKEAIATSVE-LGEDWERTE 194
+HLW+ L E + +L AL Q+ +++ W+ E + + + D + E
Sbjct: 4243 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE 4302
Query: 195 VLHKKFEDFQVELVAKEGRVVEVNQYANECAEENH-PDLPLIQSKQNEVNAAWERLRGLA 253
V K + +++A + V VN+ NE E + D ++S+ +N WE +
Sbjct: 4303 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4362
Query: 254 LQRQKAL-SNAANLQRFKRDVTEAIQWIKEKEPVLTSEDY--GKDLVASEGLFHSHKGLE 310
+R++ L S Q F ++ + + + E L++ G A E L +H L
Sbjct: 4363 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQL-DTHMELY 4421
Query: 311 RNLAVMSDKVKELCAKAEKLTLSHPSDAP--QIQEMKEDLVSSWEHIRALATSRYEKLQ- 367
L + +L K + LS + ++ L W + + R KL+
Sbjct: 4422 SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4481
Query: 368 ATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHK---HEIDSYDD 424
A F + E W+ ++N P+ + +L + ++HK +E++++ D
Sbjct: 4482 ALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILN--TVLSQIEEHKVFANEVNAHRD 4539
Query: 425 RFQSADETGQDLVNANHEASDEVREKMEI-LDNNWTALLELWDERHRQYEQCLD-FHLFY 482
+ D+TG L + + + + + + + + W +++ ER R + F+
Sbjct: 4540 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFH 4599
Query: 483 RDSEQVDSWMSRQEAFLENE-DLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATK 541
+++ W+ E+ L++E ++ N + L KH++F++ ++ T +T
Sbjct: 4600 EAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRA 4659
Query: 542 L-----IGDDHYDSEN-IKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDS-DDL 594
L + +D +N + +RD + D + K+ R+ L+E+LL + D+ L
Sbjct: 4660 LKEKTLLPEDSQKLDNFLGEVRD----KWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715
Query: 595 KNWINK-KKKLADDED-YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGH 652
+W+ K + +LA+D+ + D+ + + + +VF+KEL ++ ++++G+E+IE
Sbjct: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 4775
Query: 653 YASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FENNAEDLQRWLEDVEWQVT 711
+ V +L E+++ W+ + + + K ++L +A +Q + F + L WL + E +
Sbjct: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 4835
Query: 712 SEDYGKGLAE-VQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDS--------K 762
E +Q+ + H V ++ V+ + + HPD
Sbjct: 4836 FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWIT 4895
Query: 763 DIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPS---ATST 819
IRAR E ++ + ++ L T +L+ L E+ AWIQ E +
Sbjct: 4896 IIRARFEEVLTWAKQHQQRLETALSELVANAEL------LEELLAWIQWAETTLIQRDQE 4949
Query: 820 YLGKDLIASKKLLNRHRVILENIASHEPRIQEITER-GNKMVEEGH--FAAEDVASRVKS 876
+ +++ K L+ H+ +E + +P + +T+ K +E H F + + KS
Sbjct: 4950 PIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKS 5009
Query: 877 LNQ 879
L+Q
Sbjct: 5010 LSQ 5012
Score = 90.1 bits (222), Expect = 2e-17
Identities = 418/2301 (18%), Positives = 847/2301 (36%), Gaps = 401/2301 (17%)
Query: 96 SLEAEVQTKSRLMSELEK----TREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKG 151
S+E +++T+ + + +E+ +E R G + ++ E L L +L
Sbjct: 614 SVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSS 673
Query: 152 DQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKE 211
++ ++V L W+ +KE + + ++ F + +EL K+
Sbjct: 674 FRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQ 733
Query: 212 GRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKR 271
+ A + ENHP +++ +
Sbjct: 734 DVFRSLQDTAELLSLENHPAKQTVEA-------------------------------YSA 762
Query: 272 DVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLT 331
V +QW+K+ L E + K+ A F + LE L + D +K + +
Sbjct: 763 AVQSQLQWMKQL--CLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTS 820
Query: 332 LSHPSDAPQ-IQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKT 390
LS D Q + KE L+ S + +L +Q + S L ++ K
Sbjct: 821 LSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQL-----KPRSPDHVLKNTISVKA 875
Query: 391 AAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQD--------LVNANHE 442
D E+ + ++ + E +S +++ TG + L+ ++
Sbjct: 876 VC--------DYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNK 927
Query: 443 ASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENE 502
+ E+ ++E ++ ++ LW + H + + ++ +D + V +W
Sbjct: 928 DAIEMASRVE---QSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTW----------- 973
Query: 503 DLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA-IRDGLL 561
++K + G+ H +N++A D L
Sbjct: 974 -------------------------------NLEKLRSSAPGECHQIMKNLQAHYEDFLQ 1002
Query: 562 ARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDY-KDIQNLKSRV 620
RD++ A R RL +E + ++ +K+ N+ K+ + Y +++N++ R+
Sbjct: 1003 DSRDSVLFSVADRLRLEEEVEACKARFQHL--MKSMENEDKEETVAKMYISELKNIRLRL 1060
Query: 621 Q--KQQVFEK--ELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEAT 676
+ +Q+V ++ LA ++T + Q + E H D + L +L +
Sbjct: 1061 EEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQED--------LQQLRSDLDAVS 1112
Query: 677 KQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAV 736
+ + LH++ +L +E + D+ GL+ V L K ++ V
Sbjct: 1113 MKCDSFLHQSPSSSSVPTLRSELNLLVEKM-------DHVYGLSTVY--LNKLKTVDVIV 1163
Query: 737 AARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQ 796
+ QD +L EI + + A +L + L+ L+ K K +
Sbjct: 1164 RSIQD-----AELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDK-----NSV 1213
Query: 797 LICRDTEDEEAWIQETEPSATSTYLGKDL----IASKKLLNR-HRVI--LENIASHEPRI 849
D E +A + + S + DL +L R HRVI LE S I
Sbjct: 1214 FSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESI 1273
Query: 850 QEI-----------------TERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQ 892
QE+ T +M++ G AED + L+Q +L A R Q
Sbjct: 1274 QEVLGDYRACHGTLIKWIEETTAQQEMMKPGQ--AEDSRVLSEQLSQ-QTALFAEIERNQ 1330
Query: 893 NDLEANVQF-QQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSF 951
L+ +F QQY + + E + + V+ + +++ G K L ++
Sbjct: 1331 TKLDQCQKFSQQYSTIVKDYELQLMTYKAFVE-----SQQKSPG----KRRRMLSSSDAI 1381
Query: 952 GDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSIN 1011
LR + A V+ ++ R + + ++ ++K V LL
Sbjct: 1382 TQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEK--VKELLG--- 1436
Query: 1012 KDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLL--- 1068
W A + QG + + E +L Q+ E +T ++EQ+ ++
Sbjct: 1437 --WVSTLARNTQGKATSSETKESTDIEKAILEQQVLSE--ELTTKKEQVSEAIKTSQIFL 1492
Query: 1069 -----DRAEERRRRLLQRYNEFLLAYE-----AGDMLEWIQEKKAENTGVELDDVWELQK 1118
+E+ ++++ ++ N AY + + L+ +Q + A T
Sbjct: 1493 AKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQT------------ 1540
Query: 1119 KFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQL 1178
+ QK NT +L D+ L +G +Q+L++ + L D Q +
Sbjct: 1541 EQKTLQKQQNTCHQQLEDLCSWVGQ-AERALAGHQGRTTQQDLSALQKNQSDLKDLQDDI 1599
Query: 1179 LGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDK 1238
A + ++ + E+ + K R+L L +K
Sbjct: 1600 QNRATSFATVVKDIEGFMEENQTKLS------------------------PRELTALREK 1635
Query: 1239 VTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKA 1298
+ E E L E A ++L+ + A + ++K KE L E +K K
Sbjct: 1636 LHQAKEQYEALQEETRVAQKELEE---AVTSALQQETEKSKAAKE-LAENKK------KI 1685
Query: 1299 RDLQNWISSIGGMVSSQELAEDLTGIEIL-------------------------LERHQE 1333
L +W++S+G S +L +L G+E L L++ E
Sbjct: 1686 DALLDWVTSVGS--SGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCE 1743
Query: 1334 -----HRADMEAEAPTFQALEDFSAELIDSGHHASPE----IEKKLQAVKLE-RDDLEKA 1383
H+ + + A + A L GH+ +PE +++KL +K + L ++
Sbjct: 1744 MMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQS 1803
Query: 1384 WEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDK--SSLDSLEALMKKRDDLDK 1441
+ K++ ELQ F + + ESW+ E L + K SS ++L +L+K++ +
Sbjct: 1804 EAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSE 1863
Query: 1442 AITAQEGKITDLEHFAESLIADEHYAKEE---------IATRLQRVLDRWKALKAQLIDE 1492
+ + +G + + + ++ E+ KE + +L+ +R+ AL ++
Sbjct: 1864 DVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKC--- 1920
Query: 1493 RTKLGDYANL-----KQFYRDLEELEEWI----SEMLPTACDESYKDATNIQRKYLKHQT 1543
T+LG + N+ QF + L+ W+ + + D D +Q + +
Sbjct: 1921 -TRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQ 1979
Query: 1544 FAHEVDGRSEQVHGVINLGNSLIECSACDG-NEEAMKEQLEQLKEHWDHLLERTNDKGKK 1602
E+ V + + ++E + ++E + + H+ L ++
Sbjct: 1980 LQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSL 2039
Query: 1603 LNEA-SRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASA--GNLLKKHQLLEREMLAR 1659
L +A ++ Q S+ + E E L K Q L+S L + L++++ +
Sbjct: 2040 LQKAIAQSQSVQESLESLLQSIGEVEQNLEGK-QVSSLSSGVIQEALATNMKLKQDIARQ 2098
Query: 1660 EDALKDLNTLAEDLLSSGTFNVDQIVK-KKDNVNKRFLNVQELAAAHHEK---LKEAYAL 1715
+ +L+ + + + +++ K V++RF ++L EK LK+
Sbjct: 2099 KSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRF---EQLCLQQQEKESSLKKLLPQ 2155
Query: 1716 FQFFQDLDDE-ESWIEEKLIRVSS-----QDYGRDLQGVQNLLKKHKRLEGELVAHEPAI 1769
+ F+ L + + ++E K ++S QD Q +Q L + + + L E +
Sbjct: 2156 AEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLV 2215
Query: 1770 QNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829
+ L Q+ +Q F E + +KE K E+ E+ + ++ +
Sbjct: 2216 TELSSCGFAL--DLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQ 2273
Query: 1830 EEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQG---EDIL 1886
+ W+ E + + + + ++L +D+A T V+ + +G E+++
Sbjct: 2274 K---WLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLI 2330
Query: 1887 NKVLQEESQNK-------------------------EISSKIEALNEKTPSLAKAIAAWK 1921
++ +SQ K EI + +N K L + +
Sbjct: 2331 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2390
Query: 1922 LQLEDDY-AFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSF 1980
L+ +E + +A+ V W+ KE LK+ + T+ A+ ++ A L
Sbjct: 2391 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAEL 2450
Query: 1981 QQERLPEITDLKDKLI--------SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLL 2032
+Q P+I +K+ L S + K I+E L RWE+ E + V RQ+ L
Sbjct: 2451 EQNS-PKIQKVKEALAGLLVTYPNSQEAENWKKIQEE---LNSRWERATEVT-VARQRQL 2505
Query: 2033 EKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPV-HCVSLN-EIRQLQKDHEDFLA 2090
E + A L F S L W ME+ L V +S++ + QK F+
Sbjct: 2506 E-----ESASHLAC-FQAAESQLRPWL--MEKELMMGVLGPLSIDPNMLNAQKQQVQFML 2557
Query: 2091 SLARAQADFKCLLELDQQIK--ALGVPSSP--------YTWLTVEVLERTWKHLSDIIEE 2140
+F+ + +Q+ A G+ + P ++ + + W L+D +
Sbjct: 2558 K------EFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNS 2611
Query: 2141 REQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLK----ETGTLESQL 2196
R ++ + + + E+ Q+ + Q + A +K ET + S L
Sbjct: 2612 RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL 2671
Query: 2197 EANKRKQKEIQAMKRQLTKIV 2217
E + KE Q + +L+ ++
Sbjct: 2672 EQLDHEVKEAQTLCDELSVLI 2692
Score = 55.8 bits (133), Expect = 5e-07
Identities = 113/594 (19%), Positives = 225/594 (37%), Gaps = 105/594 (17%)
Query: 15 PKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVN 74
PKV E E I EV +R+Q ++ RV D L WI +
Sbjct: 298 PKVPEGGEGISAT--EVDSRWQEYQSRV--------------------DSLIPWIKQHTI 335
Query: 75 ILTDKSY-EDPTNIQGKYQKHQSL-EAEVQTKSR---LMSELEKTREERFTMGHSAHEET 129
+++DK++ ++P ++ Y ++ E E+ K R + EL K E G +
Sbjct: 336 LMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQG 395
Query: 130 KAHIEELRHLWDLLLELTLEKGDQLLRAL-----------KFQQYVQEC----------- 167
H ++ W L+ LE+ L A+ K Q C
Sbjct: 396 Y-HPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTL 454
Query: 168 ----------------ADILEWIGDKEAIATSVELG------EDWERTEVLHKKFEDFQV 205
+D++ +I + E + +++ E++ + E L + Q
Sbjct: 455 QADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQD 514
Query: 206 ELVA---------KEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQR 256
ELV ++G + H + + + +W R + +
Sbjct: 515 ELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFR-KPMTRAE 573
Query: 257 QKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVM 316
A+S++ + R V E + W++E + L ++G DL + E + + + ++ +
Sbjct: 574 LVAISSSEDEGNL-RFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL 632
Query: 317 SDKVKELCAKAEKLTLS-HPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRF 375
VKE K++ + H S A + +++ + + ++ ++ R LQ+ H+F
Sbjct: 633 GSSVKEARLYEGKMSQNFHTSYAETLGKLE----TQYCKLKETSSFRMRHLQS---LHKF 685
Query: 376 SSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQD 435
S W+NEK A + + + + + E++ D F+S +T +
Sbjct: 686 VSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAEL 745
Query: 436 LVNANHEASDEVREKMEILDN--NWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMS 493
L NH A V + + W L L E+H ++ + F+ D+ +++S++
Sbjct: 746 LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQH--VKENTAYFQFFSDARELESFLR 803
Query: 494 RQEAFLENE---DLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIG 544
+ ++ + D SL E LLQ D ++E++I + L+G
Sbjct: 804 NLQDSIKRKYSCDHNTSLSRLEDLLQDSMD-------EKEQLIQSKSSVASLVG 850
Score = 43.5 bits (101), Expect = 0.003
Identities = 192/1086 (17%), Positives = 400/1086 (36%), Gaps = 180/1086 (16%)
Query: 1199 IEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTIL----GETAERLSESHP 1254
+E+ L A+ G+DL SV+ + + LG V G+ ++ S+
Sbjct: 596 VEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYA 655
Query: 1255 DATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSS 1314
+ L+ Q +L E + Q + F+S+A W++ +
Sbjct: 656 ETLGKLETQYCKLKET----------SSFRMRHLQSLHKFVSRATAELIWLNEKEEEELA 705
Query: 1315 QELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVK 1374
+ +++ + I E ++E + F++L+D + L H A +E AV+
Sbjct: 706 YDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQ 765
Query: 1375 LERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLR----SDDKSSLDSLE 1430
+ +++ ++ + + F + ++ES++ ++S++ D +SL LE
Sbjct: 766 SQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLE 825
Query: 1431 ALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLI 1490
L++ D + + + + L +++++ + + + VL ++KA
Sbjct: 826 DLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPD-------HVLKNTISVKAVCD 878
Query: 1491 DERTKLGDYANLKQFYRDLEELEEW-------ISEMLPTAC-------DESYKDATNIQR 1536
+ ++ N + D + +W M+P+ C ++ + A+ +++
Sbjct: 879 YRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQ 938
Query: 1537 KYLKHQTFAHEVDGRSEQVHGVINLGNSLI----------------ECSACDGNEEA--- 1577
Y K H++ ++ + L L EC N +A
Sbjct: 939 SYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYE 998
Query: 1578 -------------------MKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRD 1618
++E++E K + HL++ ++ K E + + + + +++
Sbjct: 999 DFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDK---EETVAKMYISELKN 1055
Query: 1619 FEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDL----- 1673
L E E + + Q+ LAS+ Q + +E +DL L DL
Sbjct: 1056 IRLRLEEYEQRVVKRIQS--LASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSM 1113
Query: 1674 -------LSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEE 1726
S + +V + + + + ++ +V L+ + KLK + + QD
Sbjct: 1114 KCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQD----- 1168
Query: 1727 SWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVG 1786
E L++ G + L + + + +L A E + +KDK +V
Sbjct: 1169 ---AELLVK-----------GYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSV- 1213
Query: 1787 QEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGD 1846
+ +A+ E++ L R L LE E + ++ +E W L +R
Sbjct: 1214 FSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQE-----KGSQLQERWHRVIAQLEIR-- 1266
Query: 1847 CGDTLAATQSLLMKHEALENDFA--VHETRVQNVC---AQGEDILNKVLQEE-SQNKEIS 1900
L + Q +L + A + ET Q Q ED ++VL E+ SQ +
Sbjct: 1267 -QSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAED--SRVLSEQLSQQTALF 1323
Query: 1901 SKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADL 1960
++IE K K + + DY Q +KA V + + + + A
Sbjct: 1324 AEIERNQTKLDQCQKFSQQYS-TIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAIT 1382
Query: 1961 GDFLTLLAKQDTL------------DASLQSFQQERLPE------ITDLKDKL----ISA 1998
+F+ L + L DA + ++E++ E + +K+ L A
Sbjct: 1383 QEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLA 1442
Query: 1999 QHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQL---PLQKAEDLFVEFAHKASAL 2055
++ Q KA + +LE + + +K+ ++ ++ + HK S
Sbjct: 1443 RNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLS-- 1500
Query: 2056 NNWCEKMEENLSEPVHCV----------SLNEIRQLQKD--HEDFLASLARAQADFKCLL 2103
EK ++ +SE ++ + S N+++QLQ H+ +L + Q L
Sbjct: 1501 ----EKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQL 1556
Query: 2104 E-----LDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEM 2158
E + Q +AL T + L++ L D +++ Q A VK+ E
Sbjct: 1557 EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKD-LQDDIQNRATSFATVVKDIEG 1615
Query: 2159 CQEFEQ 2164
E Q
Sbjct: 1616 FMEENQ 1621
Score = 39.3 bits (90), Expect = 0.047
Identities = 57/294 (19%), Positives = 123/294 (41%), Gaps = 39/294 (13%)
Query: 9 VVESSGPKVLETAEE----IQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDAD 63
V++ SG +++E + + ++ + QE+ TR+ + + + +LE + +VF+
Sbjct: 4762 VLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVH 4821
Query: 64 DLGKWIMEKVNILTDKSY--EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTM 121
L +W+ E L + +D +Q H+ +V+ K ++ E +
Sbjct: 4822 MLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAV 4881
Query: 122 GHSAHEETKAH-IEELRHLWDLLLELTLEKGDQLLRAL-KFQQYVQECADILEWIGDKEA 179
H T H I +R ++ +L + +L AL + + ++L WI E
Sbjct: 4882 CHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAET 4941
Query: 180 IATSVE---LGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQ-YANECAEENH------ 229
+ + ++ +R + L + + F E+ K+ V V + Y + E H
Sbjct: 4942 TLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEK 5001
Query: 230 --------------PDLPLIQSKQ------NEVNAAWERLRGLALQRQKALSNA 263
P +P++ + N+++A W+++ LAL+RQ+ L++A
Sbjct: 5002 SRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDA 5055
Score = 36.2 bits (82), Expect = 0.40
Identities = 37/214 (17%), Positives = 80/214 (37%), Gaps = 6/214 (2%)
Query: 1622 WLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNV 1681
W+ E + L + DL S L+ Q + + ++K+ L G +
Sbjct: 595 WVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEAR------LYEGKMSQ 648
Query: 1682 DQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDY 1741
+ + + K +L +++ +L +F E W+ EK + D+
Sbjct: 649 NFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDW 708
Query: 1742 GRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHW 1801
+ + L EL + +++ D AE L + ++ ++ A
Sbjct: 709 SDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQL 768
Query: 1802 EKLKELAKARGLKLEESLEYLQFMQNAEEEEAWI 1835
+ +K+L ++E+ Y QF +A E E+++
Sbjct: 769 QWMKQLCLCVEQHVKENTAYFQFFSDARELESFL 802
Score = 35.4 bits (80), Expect = 0.69
Identities = 49/264 (18%), Positives = 108/264 (40%), Gaps = 22/264 (8%)
Query: 1727 SWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVG 1786
SW+EE +++ ++G DL V+ L+ + + + +++ K+
Sbjct: 594 SWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTS 653
Query: 1787 QEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGD 1846
E L + + KLKE + R ++ +SL +F+ A E W+NEK + D
Sbjct: 654 YAE---TLGKLETQYCKLKETSSFR-MRHLQSLH--KFVSRATAELIWLNEKEEEELAYD 707
Query: 1847 CGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKV-LQEESQNKEISSKIEA 1905
D S + ++ + Q+V +D + L+ + + + A
Sbjct: 708 WSD----NNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAA 763
Query: 1906 LNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKT------NGNGAD 1959
+ + + + + ++++ A+ +F A +E+++ + + S+K N + +
Sbjct: 764 VQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSR 823
Query: 1960 LGDFLTLLAKQDTLDASLQSFQQE 1983
L D L QD++D Q Q +
Sbjct: 824 LEDLL-----QDSMDEKEQLIQSK 842
>gi|4557241 actinin, alpha 3 [Homo sapiens]
Length = 901
Score = 188 bits (477), Expect = 6e-47
Identities = 128/500 (25%), Positives = 243/500 (48%), Gaps = 25/500 (5%)
Query: 1931 QEFNWKADVVEAWIADKETSLKTNG-NGADLGDFLTLLAKQDTLDASLQSFQQERLPEIT 1989
++F KA + EAW KE L + A L + LL + + ++ L + Q+R+ I
Sbjct: 411 EKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAA-HQDRVEHIA 469
Query: 1990 DLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFA 2049
L +L ++++ ++ R A+ +W+ L + R L + L+ + L +EFA
Sbjct: 470 ALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFA 529
Query: 2050 HKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQI 2109
+A+ NNW + E+L + S+ E + L H+ F A+L A + ++ + +I
Sbjct: 530 RRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEI 589
Query: 2110 KAL-------GVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEF 2162
+ + ++PY L+ + + W + ++ R+Q LQ+E ARQ N + ++F
Sbjct: 590 QKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQF 649
Query: 2163 EQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDN 2222
A+ WI + + + G+LE Q+ +++++ I K + ++
Sbjct: 650 AAQANAIGPWI-QAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQL 708
Query: 2223 LEDALILDIK---YSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTI 2279
L+++L+ D K YS + W+QL R + +E Q+ +D KG+S+E L EF
Sbjct: 709 LQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRAS 768
Query: 2280 YKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDY 2339
+ HFD G + +FR+CL + Y L VE F + + VDP G V+ + +
Sbjct: 769 FNHFDRKRNGMMEPDDFRACLISMGYDLGEVE-------FARIMTMVDPNAAGVVTFQAF 821
Query: 2340 TAFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQYMDPR 2399
F+ +E+ +++++ +F+ LA K+YIT E++++ L +Q +C M Y +
Sbjct: 822 IDFM-TRETAETDTTEQVVASFKILAGDKNYITPEELRRELPAKQAEYCIRRMVPY---K 877
Query: 2400 GRSHLSG-YDYVGFTNSYFG 2418
G +G DYV F+++ +G
Sbjct: 878 GSGAPAGALDYVAFSSALYG 897
Score = 64.7 bits (156), Expect = 1e-09
Identities = 95/459 (20%), Positives = 173/459 (37%), Gaps = 59/459 (12%)
Query: 1073 ERRRRLLQRYNEFLLAYEAGDMLEWIQEKKA--ENTGVELDDVWELQKKFDEFQKDLNTN 1130
+ +L++ Y + A ++LEWI+ EN E + +Q+K ++F+ +
Sbjct: 284 QENEKLMEEYEKL-----ASELLEWIRRTVPWLENRVGE-PSMSAMQRKLEDFRDYRRLH 337
Query: 1131 EPRLRDINKVADDLLFEGLLT-----------PEGAQIRQELNSRWGSLQR--------L 1171
+P R K ++ F L T P ++ ++ + W L++ L
Sbjct: 338 KPP-RIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWL 396
Query: 1172 ADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFS-VQALQRRHEGFER 1230
E R+L H E F ++A + K + LS D S L V+AL RRHE FE
Sbjct: 397 LSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFES 456
Query: 1231 DLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQK 1290
DL D+V + A+ L+E + + + + W++L T+ R+++L +K
Sbjct: 457 DLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEK 516
Query: 1291 F--------YLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEA 1342
F +A NW+ + L + + LL H + +A +
Sbjct: 517 LLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEAD 576
Query: 1343 PTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKIL---DQCLELQM 1399
A+ E+ + L D+ W+ +K++ DQ L+ ++
Sbjct: 577 RERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEEL 636
Query: 1400 ------------FQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQE 1447
F + + W+ A+ + SLE M ++ I +
Sbjct: 637 ARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYK 696
Query: 1448 GKITDLEH----FAESLIADEH---YAKEEIATRLQRVL 1479
I LE ESL+ D Y+ E I +++L
Sbjct: 697 TNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL 735
Score = 58.9 bits (141), Expect = 6e-08
Identities = 89/391 (22%), Positives = 156/391 (39%), Gaps = 58/391 (14%)
Query: 1717 QFFQDLDDEESWIEEKLIRVSSQDYGRDL-QGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775
+F Q E+W K +S +DY L Q V+ LL++H+ E +L AH+ ++++ +
Sbjct: 412 KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAAL 471
Query: 1776 AEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLE------ESLEYLQ--FMQN 1827
A++L + + R + W+ L L + R LE E+++ LQ F +
Sbjct: 472 AQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARR 531
Query: 1828 AEEEEAWINEKNALAVRGDCG--DTLAATQSLLMKHEALENDF-AVHETRVQNVCAQGED 1884
A W++ A+ D ++ TQSLL H+ + R + QGE
Sbjct: 532 AAPFNNWLD--GAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGE- 588
Query: 1885 ILNKVLQEE-----SQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWK--- 1936
+ K+ Q S N I+ + +N K + K + + L+++ A Q+ N +
Sbjct: 589 -IQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRR 647
Query: 1937 -----ADVVEAWIADK--ETSLKTNGNGADLGDFLTLLAKQ-----------DTLDASLQ 1978
A+ + WI K E G L + + L +Q D L+ Q
Sbjct: 648 QFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQ 707
Query: 1979 SFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPL 2038
Q+ + D K + S +H + WEQLL S +E Q+
Sbjct: 708 LLQESL---VFDNKHTVYSMEH------------IRVGWEQLL-TSIARTINEVENQVLT 751
Query: 2039 QKAEDLFVEFAHKASALNNWCEKMEENLSEP 2069
+ A+ L E ++ A N ++ + EP
Sbjct: 752 RDAKGLSQEQLNEFRASFNHFDRKRNGMMEP 782
Score = 54.7 bits (130), Expect = 1e-06
Identities = 37/169 (21%), Positives = 79/169 (46%), Gaps = 16/169 (9%)
Query: 575 RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD--IQNLKSRVQKQQVFEKELAV 632
RRL + L +K + + + W K+++ DY +Q +++ +++ + FE +LA
Sbjct: 401 RRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAA 460
Query: 633 NKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQ---- 688
++ ++E+I QE+ E ++ + +V +R + W+ L T+++ L +
Sbjct: 461 HQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLET 520
Query: 689 ----QLQFENNAEDLQRWL----EDVE--WQVTSEDYGKGLAEVQNRLR 727
QL+F A WL ED++ W V S + + L ++ +
Sbjct: 521 IDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFK 569
Score = 52.8 bits (125), Expect = 4e-06
Identities = 55/240 (22%), Positives = 103/240 (42%), Gaps = 14/240 (5%)
Query: 608 EDYKDIQNLKSRVQKQQVFEKELAVNKTQLE-NIQKTGQEMIEGGHYASD--NVTTRLSE 664
ED++D + L + Q+ + E+ N Q + + M G SD N L +
Sbjct: 328 EDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQ 387
Query: 665 VASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLA-EVQ 723
V +E+ L + ++ +L ++ F A + W E ++ DY L EV+
Sbjct: 388 VEKGYEDWLLSEIRRLQRLQHLAEK--FRQKASLHEAWTRGKEEMLSQRDYDSALLQEVR 445
Query: 724 NRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEAL----- 778
LR+H ES +AA QD+V+ + LA E+ + ++ + +R +++ +++ L
Sbjct: 446 ALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQ 505
Query: 779 -KEPLATRKKKLLDLL-HLQL-ICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRH 835
+ R +KLL+ + LQL R W+ +L + ++ LL H
Sbjct: 506 KRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAH 565
Score = 51.6 bits (122), Expect = 9e-06
Identities = 39/158 (24%), Positives = 67/158 (42%), Gaps = 1/158 (0%)
Query: 2017 WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSE-PVHCVSL 2075
W L + + LL + LQ+ + L +F KAS W EE LS+ L
Sbjct: 382 WRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALL 441
Query: 2076 NEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLS 2135
E+R L + HE F + LA Q + + L Q++ L + + + W +L
Sbjct: 442 QEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLG 501
Query: 2136 DIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173
+ ++R L++ E ++ EF + A+ F W+
Sbjct: 502 TLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWL 539
Score = 48.5 bits (114), Expect = 8e-05
Identities = 63/291 (21%), Positives = 113/291 (38%), Gaps = 33/291 (11%)
Query: 161 QQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQ-VELVAKEGRVVE--- 216
++Y + +++LEWI + +GE + +K EDF+ + K R+ E
Sbjct: 291 EEYEKLASELLEWIR-RTVPWLENRVGEP--SMSAMQRKLEDFRDYRRLHKPPRIQEKCQ 347
Query: 217 ----VNQYANECAEENHPDLPLIQSKQ-NEVNAAWERLRGLA----------LQRQKALS 261
N + + P + K +++ AW L + ++R + L
Sbjct: 348 LEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQ 407
Query: 262 NAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVAS-EGLFHSHKGLERNLAVMSDKV 320
+ A R K + EA W + KE +L+ DY L+ L H+ E +LA D+V
Sbjct: 408 HLAEKFRQKASLHEA--WTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRV 465
Query: 321 KELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRAL------ATSRYEKLQAT--YWY 372
+ + A A++L +A + + + W+++ L A R EKL T
Sbjct: 466 EHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQ 525
Query: 373 HRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYD 423
F+ + W++ + L V + LL H Q K + D
Sbjct: 526 LEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEAD 576
Score = 45.4 bits (106), Expect = 7e-04
Identities = 56/239 (23%), Positives = 99/239 (41%), Gaps = 28/239 (11%)
Query: 2039 QKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQAD 2098
Q+ E L E+ AS L W + L V S++ +++ +D D+ +
Sbjct: 284 QENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQ 343
Query: 2099 FKCLLE-----LDQQIKALGVPS-SPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQ 2152
KC LE L +++ P+ P V + W+ L + + E L E R
Sbjct: 344 EKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRL 403
Query: 2153 VKNFEMCQEFEQNASTFLQW------ILETRAYFLDGSLLKETGTL-------ESQLEAN 2199
+ + ++F Q AS W +L R Y D +LL+E L ES L A+
Sbjct: 404 QRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDY--DSALLQEVRALLRRHEAFESDLAAH 461
Query: 2200 KRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQ 2258
+ + + I A+ ++L ++ + +A ++ + I QWD L L + + LE+
Sbjct: 462 QDRVEHIAALAQELNEL-----DYHEAASVNSRCQAI--CDQWDNLGTLTQKRRDALER 513
Score = 44.7 bits (104), Expect = 0.001
Identities = 93/506 (18%), Positives = 197/506 (38%), Gaps = 74/506 (14%)
Query: 262 NAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVK 321
N ++ +++ +E ++WI+ P L + + A + + R +++
Sbjct: 286 NEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRR--LHKPPRIQ 343
Query: 322 ELC-------AKAEKLTLSH-PSDAPQIQEMKEDLVSSWEHIRALATS----------RY 363
E C KL LSH P+ P ++ D+ ++W + + R
Sbjct: 344 EKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRL 403
Query: 364 EKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGG-EVLLDRHQQHKHEIDSY 422
++LQ R + E W K ++ + + + LL RH+ + ++ ++
Sbjct: 404 QRLQHLAEKFRQKASLHE--AWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAH 461
Query: 423 DDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERH---RQYEQCLD-- 477
DR + Q+L ++ + V + + + + W L L +R + E+ L+
Sbjct: 462 QDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETI 521
Query: 478 --FHL-FYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEK--- 531
L F R + ++W+ L++ L +S+ ++LL H+ F+ + +
Sbjct: 522 DQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGA 581
Query: 532 IITVDKTATKLIGD----DHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKL 587
I+ + K+ + I + + D +R+ +R + L+E L Q++
Sbjct: 582 IMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQV 641
Query: 588 YE--------DSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLEN 639
E ++ + WI K +++ L + + E+++A + Q +N
Sbjct: 642 NERLRRQFAAQANAIGPWIQAK--------VEEVGRLAAGLAGS--LEEQMAGLRQQEQN 691
Query: 640 I--QKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAE 697
I KT + +EG H L +E L K T + ++ +E
Sbjct: 692 IINYKTNIDRLEGDH--------------QLLQESL-VFDNKHTVYSMEHIRVGWEQLLT 736
Query: 698 DLQRWLEDVEWQVTSEDYGKGLAEVQ 723
+ R + +VE QV + D KGL++ Q
Sbjct: 737 SIARTINEVENQVLTRD-AKGLSQEQ 761
Score = 43.1 bits (100), Expect = 0.003
Identities = 49/235 (20%), Positives = 96/235 (40%), Gaps = 11/235 (4%)
Query: 782 LATRKKKLLDLLHLQLICRDTED-EEAWIQETEPSATSTYLGKDLIAS-KKLLNRHRVIL 839
L + ++L L HL R EAW + E + L+ + LL RH
Sbjct: 396 LLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFE 455
Query: 840 ENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANV 899
++A+H+ R++ I ++ E + A V SR +++ ++L +R++ LE
Sbjct: 456 SDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALE--- 512
Query: 900 QFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALR 959
+ ++ L + + + + +N GA E+ L L + D KA
Sbjct: 513 RMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATL 572
Query: 960 NQANACQQQQAAPVEGVAGE-QRVMALYDFQARSPRE-VTMKKGDVLTLLSSINK 1012
+A+ ++ + G+ GE Q++ Y + S +T+ D+ T + K
Sbjct: 573 PEAD----RERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRK 623
Score = 39.3 bits (90), Expect = 0.047
Identities = 66/312 (21%), Positives = 125/312 (40%), Gaps = 46/312 (14%)
Query: 489 DSWMSRQEAFLENEDLGNSL-GSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDH 547
++W +E L D ++L ALL++HE FE A ++++ + A +L D+
Sbjct: 421 EAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDY 480
Query: 548 YDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLK-----------N 596
+++ ++ + + + D L RR L+ ++KL E D L+ N
Sbjct: 481 HEAASVNSRCQAICDQWDNLGTLTQKRRDALER---MEKLLETIDQLQLEFARRAAPFNN 537
Query: 597 WINKKKKLADD----EDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIE--G 650
W++ + D ++ Q+L + + + E + + IQ Q++ + G
Sbjct: 538 WLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYG 597
Query: 651 GHYASDN--VTTRLSEVASLWEELLEATKQKGTQLHE--ANQQL------QFENNAEDLQ 700
S N +T ++ + W+ + + + L E A QQ+ QF A +
Sbjct: 598 LRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIG 657
Query: 701 RWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPD 760
W+ Q E+ G+ A + L E RQ + +I+ Y I +
Sbjct: 658 PWI-----QAKVEEVGRLAAGLAGSLE-----EQMAGLRQQEQNIIN----YKTNIDRLE 703
Query: 761 SKDIRARQESLV 772
D + QESLV
Sbjct: 704 G-DHQLLQESLV 714
Score = 38.1 bits (87), Expect = 0.11
Identities = 41/232 (17%), Positives = 87/232 (37%), Gaps = 18/232 (7%)
Query: 47 QKLEDSYHL-QVFKRDADDLGKWIMEKVNILTDKSYEDPT--NIQGKYQKHQSLEAEVQT 103
++L+ HL + F++ A W K +L+ + Y+ ++ ++H++ E+++
Sbjct: 401 RRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAA 460
Query: 104 KSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQ- 162
+ + +E + + + + + WD L LT ++ D L R K +
Sbjct: 461 HQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLET 520
Query: 163 -------YVQECADILEWIGDKEAIATSVELGEDWERTEVL---HKKFEDFQVELVAKEG 212
+ + A W+ V L E T+ L H +F+ E + G
Sbjct: 521 IDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERG 580
Query: 213 RVV----EVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKAL 260
++ E+ + P I ++N W+ +R L R + L
Sbjct: 581 AIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTL 632
>gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5
[Homo sapiens]
Length = 678
Score = 185 bits (469), Expect = 5e-46
Identities = 143/643 (22%), Positives = 281/643 (43%), Gaps = 9/643 (1%)
Query: 78 DKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELR 137
D + ED + ++ +HQ+ AE+ + ++E+ ++ + + E+R
Sbjct: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIR 65
Query: 138 HLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLH 197
W L T K QL A K Q VQ A++ + + E+ V+ G D
Sbjct: 66 QCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL 125
Query: 198 KKFEDFQVELVAKEGRVVEVNQYANECAEENHP-DLPLIQSKQNEVNAAWERLRGLALQR 256
KK + + ++ V E+ A A P L+ +QN V RL +R
Sbjct: 126 KKLQSMESQVEEWYREVGELQ--AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER 183
Query: 257 QKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVM 316
++ L + L + D+ + + W++E+ P+ + G L A + ++GL R +
Sbjct: 184 RRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243
Query: 317 SDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFS 376
+++E+ +A L +A ++ E L S+W +R A R + L A + ++
Sbjct: 244 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 303
Query: 377 SDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDL 436
D E+ W+ E+ + +++ D LL +H Q + +++Y++ + L
Sbjct: 304 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 363
Query: 437 VNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQE 496
+ H S+++ + +D + AL EL +ER EQ + R +++ W++ +E
Sbjct: 364 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423
Query: 497 AFLENEDLGNSLGSAEALLQKHEDF-EEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555
+ +LG L +K +F E A E++ V++ +LI H + +
Sbjct: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 483
Query: 556 IRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWI-NKKKKLADDEDYKDIQ 614
+DGL L E TR +LL S L K + D+ +L+ I K+++L + +
Sbjct: 484 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPR 543
Query: 615 NLKSRVQKQ-QVFEKELAVNKTQLENIQKTGQEM--IEGGHYASDNVTTRLSEVASLWEE 671
S +Q+ + FE +L + +Q+ +Q+ ++ + G +A + + +R EV W+E
Sbjct: 544 PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA-EAIASREQEVLQGWKE 602
Query: 672 LLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSED 714
LL A + + L+F + DL W++ + Q+ + D
Sbjct: 603 LLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645
Score = 164 bits (415), Expect = 1e-39
Identities = 116/378 (30%), Positives = 184/378 (48%), Gaps = 3/378 (0%)
Query: 604 LADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLS 663
+A D +D L R + Q F ELA NK LE I++ GQ++++ + +V +L
Sbjct: 3 MARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG 62
Query: 664 EVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQ 723
E+ W EL T+ K QL EA++ Q + +L + L +E Q+ D G LA V
Sbjct: 63 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVN 122
Query: 724 NRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKD-IRARQESLVCRFEALKEPL 782
++L+K +ES V +V L A P SK+ + RQ ++ R L EPL
Sbjct: 123 SQLKKLQSMESQVEEWYREVGELQAQTAALPL--EPASKELVGERQNAVGERLVRLLEPL 180
Query: 783 ATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENI 842
R++ LL L + D +DE AW+QE P A T G L A ++ + +++ + I
Sbjct: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
Query: 843 ASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQ 902
+H PR++E+ ER + AE V ++ L LR A RRQ L+A Q +
Sbjct: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
Query: 903 QYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQA 962
QY D+ E E W+ E+E ++ + + G DE++ LLKKH + ++ +S+ L Q
Sbjct: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360
Query: 963 NACQQQQAAPVEGVAGEQ 980
A + E ++ Q
Sbjct: 361 RALLEMGHPDSEQISRRQ 378
Score = 160 bits (406), Expect = 1e-38
Identities = 126/511 (24%), Positives = 226/511 (44%), Gaps = 10/511 (1%)
Query: 1523 ACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQL 1582
A D + +D + +++L+HQ F E+ E + + G L++ +++++L
Sbjct: 4 ARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP--ELAASVRKKL 61
Query: 1583 EQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASA 1642
++++ W L T K ++L EAS+ + S + + L E+ L D DLA+
Sbjct: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121
Query: 1643 GNLLKKHQLLEREMLAREDALKDLNTLAEDL--LSSGTFNVDQIVKKKDNVNKRFLNVQE 1700
+ LKK Q +E ++ E+ +++ L L + + + ++++ V +R + + E
Sbjct: 122 NSQLKKLQSMESQV---EEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLE 178
Query: 1701 LAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEG 1760
L + L Q DLDDE +W++E+L + G LQ VQ +KK++ L
Sbjct: 179 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 238
Query: 1761 ELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLE 1820
E+ AH P ++ VL+ A L + E ++ L Q W L+E A+ R L+ + +
Sbjct: 239 EIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQ 298
Query: 1821 YLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCA 1880
Q+ + E EAW+ E+ L + D G +T LL KH LE +E + +
Sbjct: 299 VEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSR 358
Query: 1881 QGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVV 1940
Q +L + Q S+++ L L + ++ LE Y + + + +
Sbjct: 359 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGE---ERRVALEQQYWLYQLSRQVSEL 415
Query: 1941 EAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQH 2000
E WIA+KE + G D L K + +ERL + + D+LI H
Sbjct: 416 EHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH 475
Query: 2001 NQSKAIEERYAALLKRWEQLLEASAVHRQKL 2031
+ + E L + W +LLE Q L
Sbjct: 476 TAAATMAEWKDGLNEAWAELLELMGTRAQLL 506
Score = 143 bits (360), Expect = 2e-33
Identities = 132/564 (23%), Positives = 236/564 (41%), Gaps = 22/564 (3%)
Query: 411 RHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHR 470
RHQ E+ + + + GQ L+ E + VR+K+ + W L + R
Sbjct: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
Query: 471 QYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEE 530
Q + + ++D + E+ L++ D G L + + L+K + E
Sbjct: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
Query: 531 KI---------ITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKES 581
++ + ++ + +L+G E A+ + L+ + L+E RRRLL S
Sbjct: 141 EVGELQAQTAALPLEPASKELVG------ERQNAVGERLVRLLEPLQE----RRRLLLAS 190
Query: 582 LLLQKLYEDSDDLKNWINKKKKLA-DDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENI 640
L ++ D DD W+ ++ LA E +Q ++ ++K Q +E+ + +LE +
Sbjct: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
Query: 641 QKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQ 700
+ + ++ V L ++ S W L EA +++ L A Q Q+ + +++
Sbjct: 251 LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVE 310
Query: 701 RWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPD 760
WL + E + SED GK L+KH LE V ++ + L+ E+GHPD
Sbjct: 311 AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370
Query: 761 SKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY 820
S+ I RQ + + ALKE R+ L L + R + E WI E E A S
Sbjct: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE 430
Query: 821 LGKDLIASKKLLNRHRVIL-ENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQ 879
LG+D L + E + R+ + + ++++E GH AA +A LN+
Sbjct: 431 LGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNE 490
Query: 880 NMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDN-TNYGADEEAAGALL 938
L R L A+ + ++ +D E + I EK + T +A ++
Sbjct: 491 AWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ 550
Query: 939 KKHEAFLLDLNSFGDSMKALRNQA 962
+ AF DL ++ L+ A
Sbjct: 551 RTLRAFEHDLQLLVSQVRQLQEGA 574
Score = 128 bits (321), Expect = 8e-29
Identities = 109/485 (22%), Positives = 221/485 (45%), Gaps = 33/485 (6%)
Query: 1053 ITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEK----KAENTGV 1108
+ +RQ + + LL+ +ERRR LL +A++ D L W+QE+ G
Sbjct: 162 VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGN 221
Query: 1109 ELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR---QELNSRW 1165
L V + KK ++++ + PRL ++ + A L L +PE +R ++L S W
Sbjct: 222 GLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA--SLRSPEAEAVRRGLEQLQSAW 279
Query: 1166 GSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRH 1225
L+ A+ ++Q+L +A VE ++ + + + + ++ + + D G D S L ++H
Sbjct: 280 AGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKH 339
Query: 1226 EGFERDLVPLGDKVTILGETAERLSE-SHPDATEDLQRQKMELNEAWEDLQGRTKDRKES 1284
E+ + + + L L E HPD +E + R++ +++ + L+ ++R+ +
Sbjct: 340 LQLEQGVENYEESIAQLSRQCRALLEMGHPD-SEQISRRQSQVDRLYVALKELGEERRVA 398
Query: 1285 LNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADM-EAEAP 1343
L + Y + +L++WI+ + S EL +D + +L E+ E ++ A
Sbjct: 399 LEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRE 458
Query: 1344 TFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEK-------RKKILDQCLE 1396
A+ ELI+ GH A+ + + +D L +AW + R ++L E
Sbjct: 459 RLAAVNQMVDELIECGHTAAATMAE-------WKDGLNEAWAELLELMGTRAQLLAASRE 511
Query: 1397 LQMFQGNCDQVESWMVARENSL-----RSDDKSSLDSLEALMKKRDDLDKAITAQEGKIT 1451
L F + +++ + + L + + S S++ ++ + + + +Q ++
Sbjct: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ 571
Query: 1452 DLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEE 1511
+ ++ A EH E IA+R Q VL WK L + D R + A+ +F+ + +
Sbjct: 572 EGAAQLRTVYAGEH--AEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRD 629
Query: 1512 LEEWI 1516
L W+
Sbjct: 630 LLSWM 634
Score = 125 bits (315), Expect = 4e-28
Identities = 116/483 (24%), Positives = 199/483 (41%), Gaps = 20/483 (4%)
Query: 22 EEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY 81
E + ER+ V R E + ER + L S L D DD W+ E++ +
Sbjct: 160 ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTER 219
Query: 82 EDPTN-IQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLW 140
+ +Q +K+Q L E+Q + E+ + ++ E + +E+L+ W
Sbjct: 220 GNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW 279
Query: 141 DLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKF 200
L E + L A + +QY + A++ W+G++E + S + G+D + T L KK
Sbjct: 280 AGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKH 339
Query: 201 EDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKAL 260
+ + E + ++++ E HPD I +Q++V+ + L+ L +R+ AL
Sbjct: 340 LQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVAL 399
Query: 261 SNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKD------LVASEGLFHSHKGL--ERN 312
L + R V+E WI EKE V S + G+D L F S G+
Sbjct: 400 EQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRER 459
Query: 313 LAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWY 372
LA ++ V EL + H + A + E K+ L +W + L +R + L A+
Sbjct: 460 LAAVNQMVDEL------IECGHTA-AATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 512
Query: 373 HRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRH-QQHKHEIDSYDDRFQSADE 431
H+F SD EL G + EK + P + + R + +H++ + + E
Sbjct: 513 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQE 572
Query: 432 TGQDL--VNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVD 489
L V A A + E+L W LL ++ D F+ +
Sbjct: 573 GAAQLRTVYAGEHAEAIASREQEVL-QGWKELLSACEDARLHVSSTADALRFHSQVRDLL 631
Query: 490 SWM 492
SWM
Sbjct: 632 SWM 634
Score = 117 bits (292), Expect = 2e-25
Identities = 92/386 (23%), Positives = 179/386 (46%), Gaps = 10/386 (2%)
Query: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILT--D 78
AE ++ +++ + + +E R Q L+ ++ ++ + D ++ W+ E+ ++ D
Sbjct: 265 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 324
Query: 79 KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRH 138
K ++ + +Q +KH LE V+ +++L + MGH E+ ++
Sbjct: 325 KGKDEQSTLQ-LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDR 383
Query: 139 LWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHK 198
L+ L EL E+ L + Q ++ +++ WI +KE +A S ELG+D+E VL +
Sbjct: 384 LYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQE 443
Query: 199 KFEDFQVEL-VAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQ 257
KF +F E +A R+ VNQ +E E H + ++ +N AW L L R
Sbjct: 444 KFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRA 503
Query: 258 KALSNAANLQRFKRDVTEAIQWIKEKE---PVLTSEDYGKDLVASEGLFHSHKGLERNLA 314
+ L+ + L +F D E I+EK P LT+ + +S + + + E +L
Sbjct: 504 QLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS--MQRTLRAFEHDLQ 561
Query: 315 VMSDKVKELCAKAEKL-TLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYH 373
++ +V++L A +L T+ A I +++++ W+ + + + +T
Sbjct: 562 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL 621
Query: 374 RFSSDFDELSGWMNEKTAAINADELP 399
RF S +L WM+ + I A + P
Sbjct: 622 RFHSQVRDLLSWMDGIASQIGAADKP 647
Score = 115 bits (287), Expect = 7e-25
Identities = 124/634 (19%), Positives = 269/634 (42%), Gaps = 40/634 (6%)
Query: 1224 RHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKE 1283
RH+ F +L + + + ++L + P+ ++++ E+ + W +L+ T+ +
Sbjct: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
Query: 1284 SLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEA--- 1340
L EA K + +L + + + + DL + L++ Q + +E
Sbjct: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
Query: 1341 EAPTFQA------LEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQC 1394
E QA LE S EL+ +A E +L R L + ++R+++L
Sbjct: 141 EVGELQAQTAALPLEPASKELVGERQNAVGE--------RLVR--LLEPLQERRRLLLAS 190
Query: 1395 LELQMFQGNCDQVESWMVAR-ENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDL 1453
EL + D +W+ R +++++ + L +++ +KK L + I A ++ ++
Sbjct: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
Query: 1454 EHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYA-NLKQFYRDLEEL 1512
A +L + E + L+++ W L+ + + R ++ D A ++Q+Y D+ E+
Sbjct: 251 LERAGALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEV 309
Query: 1513 EEWISEM-LPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSAC 1571
E W+ E L ++ KD + + KH V+ E + + +L+E
Sbjct: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369
Query: 1572 DGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQ----RFNTSIRDFEFWLSEAE 1627
D EQ+ + + D L + G++ A QQ + + + + E W++E E
Sbjct: 370 DS------EQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423
Query: 1628 TLLAMKDQARDLASAGNLLKKHQLLEREM-LAREDALKDLNTLAEDLLSSGTFNVDQIVK 1686
+ + +D L +K E +A + L +N + ++L+ G + +
Sbjct: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 483
Query: 1687 KKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEK---LIRVSSQDYGR 1743
KD +N+ + + EL + L + L +FF D + + IEEK L R+++ R
Sbjct: 484 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPR 543
Query: 1744 DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKD-KAAVGQEEIQLRLAQFVEHWE 1802
++ + + E +L ++ + + A +L+ A E I R + ++ W+
Sbjct: 544 --PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWK 601
Query: 1803 KLKELAKARGLKLEESLEYLQFMQNAEEEEAWIN 1836
+L + L + + + L+F + +W++
Sbjct: 602 ELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635
Score = 108 bits (270), Expect = 6e-23
Identities = 139/650 (21%), Positives = 271/650 (41%), Gaps = 28/650 (4%)
Query: 1111 DDVWELQKKF---DEFQKDLNTNEPRLRDINKVADDLLFEGLLTPE-GAQIRQ---ELNS 1163
+D +L K++ F +L N+ L I + L+ E PE A +R+ E+
Sbjct: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQE---KPELAASVRKKLGEIRQ 66
Query: 1164 RWGSLQRLADEQ-RQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQ 1222
W L+ + RQL ++ A ++ A+ K+ + + Q L DPG DL +V +
Sbjct: 67 CWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQ-LQDVDPGGDLATVNSQL 125
Query: 1223 RRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRK 1282
++ + E + +V L L P + E + ++ + E L ++R+
Sbjct: 126 KKLQSMESQVEEWYREVGELQAQTAAL-PLEPASKELVGERQNAVGERLVRLLEPLQERR 184
Query: 1283 ESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEA 1342
L +++ + D W+ + E L ++ ++++Q R +++A
Sbjct: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHG 244
Query: 1343 PTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQG 1402
P + + + + L + + + L+ ++ L +A E+R+++LD +++ +
Sbjct: 245 PRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 304
Query: 1403 NCDQVESWMVARENSLRSDDKSSLD-SLEALMKKRDDLDKAITAQEGKITDLEHFAESLI 1461
+ +VE+W+ +E + S+DK + S L+KK L++ + E I L +L+
Sbjct: 305 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 364
Query: 1462 ADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEM-L 1520
H E+I+ R +V + ALK + R L L Q R + ELE WI+E +
Sbjct: 365 EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV 424
Query: 1521 PTACDESYKDATNIQRKYLKHQTFAHE--VDGRSEQVHGVINLGNSLIECSACDGNEEAM 1578
E +D ++ K FA E + GR E++ V + + LIEC M
Sbjct: 425 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGR-ERLAAVNQMVDELIECGHTAA--ATM 481
Query: 1579 KEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLL-AMKDQAR 1637
E + L E W LLE + + L + +F + R+ + + E L +
Sbjct: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541
Query: 1638 DLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLS-SGTFNVDQIVKKKDNVN---K 1693
SA ++ + + E ++ ++ L A L + + + I ++ V K
Sbjct: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWK 601
Query: 1694 RFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGR 1743
L+ E A H +A +F + D SW++ ++ + D R
Sbjct: 602 ELLSACEDARLHVSSTADA---LRFHSQVRDLLSWMDGIASQIGAADKPR 648
Score = 83.2 bits (204), Expect = 3e-15
Identities = 120/634 (18%), Positives = 252/634 (39%), Gaps = 52/634 (8%)
Query: 834 RHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQN 893
RH+ + +A ++ +++I G ++++E A V ++ + Q L + +
Sbjct: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
Query: 894 DLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGD 953
L + Q + E + + E + + + G D + LKK ++ + +
Sbjct: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
Query: 954 SMKALRNQANACQQQQAAPV-----EGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLS 1008
+ L+ Q A + A+ + GE+ V L Q R R + + ++ +
Sbjct: 141 EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER--RRLLLASKELHQVAH 198
Query: 1009 SINKDW-WKVEA--------------ADHQGIVPAVYVRRLAHDEFPMLPQ--------- 1044
++ + W E A Q I +RR P L +
Sbjct: 199 DLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 258
Query: 1045 -RRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK- 1102
R E + + EQ+++ + L + AE R++ L + ++ ++ W+ E++
Sbjct: 259 SLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQEL 318
Query: 1103 ---AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQI-- 1157
+E+ G + +L KK + ++ + E + +++ LL G P+ QI
Sbjct: 319 LMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMG--HPDSEQISR 376
Query: 1158 -RQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLF 1216
+ +++ + +L+ L +E+R L + + R+ + + I +K + + G D
Sbjct: 377 RQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFE 436
Query: 1217 SVQALQRRHEGFERDLVPLG-DKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQ 1275
V LQ + F + G +++ + + + L E A + K LNEAW +L
Sbjct: 437 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELL 496
Query: 1276 GRTKDRKESLNEAQKFYLFLSKARDLQNWISS----IGGMVSSQELAEDLTGIEILLERH 1331
R + L +++ + F S AR+LQ I + + + E + ++ L R
Sbjct: 497 ELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL-RA 555
Query: 1332 QEHRADMEAEAPTFQALEDFSAEL--IDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKK 1389
EH D++ + L++ +A+L + +G HA I + Q V +L A E +
Sbjct: 556 FEH--DLQLLVSQVRQLQEGAAQLRTVYAGEHAE-AIASREQEVLQGWKELLSACEDARL 612
Query: 1390 ILDQCLELQMFQGNCDQVESWMVARENSLRSDDK 1423
+ + F + SWM + + + DK
Sbjct: 613 HVSSTADALRFHSQVRDLLSWMDGIASQIGAADK 646
>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
[Homo sapiens]
Length = 8797
Score = 150 bits (380), Expect = 1e-35
Identities = 482/2552 (18%), Positives = 986/2552 (38%), Gaps = 302/2552 (11%)
Query: 2 EQFPKETV-VESSGPKVLETAEEIQ---ERRQEVLTRYQSFKERVAERGQKLEDSYH-LQ 56
++F K T + +++ A EI + +Q + + +S KE+V + LE+ ++
Sbjct: 1383 KEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTME 1442
Query: 57 VFKRDADDLGK-------WIMEKVNIL----TDKSYEDPT---------NIQGKYQKHQS 96
+ K D G WI EK L T S D I+ K
Sbjct: 1443 MVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVG 1502
Query: 97 LEAEVQTKSRLMSELEKTR-EERFTMGHSAHEETKAHIEELRHLWDLLLELTLE-KGDQL 154
LE E Q+ ++ ++ E R + + T EE + H + L +L L+ + K ++
Sbjct: 1503 LEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGT--ILGHLSQQQKFEEN 1560
Query: 155 LRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRV 214
LR K QQ V E D L A +++ T + ++ D L + +
Sbjct: 1561 LR--KIQQSVSEFEDKL---------AVPIKICSSATETYKVLQEHMDLCQALESLSSAI 1609
Query: 215 VEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNA-ANLQRFKRDV 273
+ A + + + + +E + A +RQ AL N A+ QR ++++
Sbjct: 1610 TAFSASARKVVNRDS-----CVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKEL 1664
Query: 274 TEAIQWIKEKEPVLTSE--DYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKL- 330
+ + W++ E +S D D V EG + L+ + + +L E L
Sbjct: 1665 SSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLF 1724
Query: 331 TLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDEL----SGWM 386
+++ D ++ E L W + + R LQ+ H+ FDEL S W+
Sbjct: 1725 SVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQ---QFDELLLSFSVWI 1781
Query: 387 NEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADE---------TGQDLV 437
+ + + +V L RH+ H E++S QS +DL
Sbjct: 1782 KLFLSELQTTS-EISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLH 1840
Query: 438 NANHEASDEVR---EKMEILDNNWTALLELWD--ERHRQYEQCLDFHLFYRDSEQVDSWM 492
+A D + E ++++ AL L + + H L R + + + M
Sbjct: 1841 LLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQ---LRQTVEATNSM 1897
Query: 493 SRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSEN 552
++ E+ L +DL ++L +A+AL E+ + I++ + K+ + S
Sbjct: 1898 NKNESDLIEKDLNDALQNAKAL--------ESAAVSLDGILSKAQYHLKIGSSEQRTS-- 1947
Query: 553 IKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDS-DDLKNWINKKKKLADDEDYK 611
+A D L + ++ T++ +L+K ++D ++L I ++ D E K
Sbjct: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007
Query: 612 DI--QNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLW 669
+ Q L+ R++ E EL ++ +L ++ +++ + + V ++ + W
Sbjct: 2008 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTW 2067
Query: 670 EELLEATKQ-KGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRK 728
++ + +G + +++N + + LE+ + + K +++ K
Sbjct: 2068 DDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSK 2127
Query: 729 HGLLESAVAARQDQVDILTD----LAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLAT 784
H ++ + +Q +D T L + ++I D ++ ES V ++ + E L
Sbjct: 2128 HETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEE 2187
Query: 785 RKKKLLDLLHLQLICRDTEDE-EAWIQETEPSATSTYLGKDL-IASKKLLNRHRVILENI 842
+L L + T DE E W P D + +++LL ++N
Sbjct: 2188 NMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNK 2247
Query: 843 ASHEPRIQEITERGNKMVE--EGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE---- 896
A R++E+ + N + E + D+ L Q +E + + L+
Sbjct: 2248 AL---RLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTA 2304
Query: 897 ANVQFQQYLADLHEAETWIRE---------------------KEPIVDNTNYGADEEAAG 935
+ Q ++++ D+ T + E KE +N + +E
Sbjct: 2305 QSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLN 2364
Query: 936 ALLKKHEAFLLDLNSFGDSMKALRNQANA----CQQQQAAPVEGVAGEQRVMALYDFQA- 990
+L +K+ + +L S G +M L + A C + QA+ E + + ++ +FQ
Sbjct: 2365 SLCRKYHS--AELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE-KHFSESMQEFQEW 2421
Query: 991 -----RSPREVTMKKGD----------VLTLLSSINKDWWKVEAADHQGIVPAVYV-RRL 1034
+ +E + + GD + +L S++ K++A +G ++ +++
Sbjct: 2422 FLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQI 2481
Query: 1035 AHDEFPMLPQRRREEPGNITQ--RQEQIENQYRSLLDRAEERRRRL---LQRYNEFLLAY 1089
+ + E + Q + +Q S L E++ R+L + E
Sbjct: 2482 VSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTE 2541
Query: 1090 EAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGL 1149
G+ + I EKK E VE+ F +L L +++ L EG
Sbjct: 2542 NLGESKQHIPEKKNEVHKVEM------------FLGELLAARESLDKLSQRGQLLSEEGH 2589
Query: 1150 LTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALS-- 1207
+ ++ +L + +L R+ E+ L S H ++ + + +A+
Sbjct: 2590 GAGQEGRLCSQLLTSHQNLLRMTKEK---LRSCQVALQEHEALEEALQSMWFWVKAIQDR 2646
Query: 1208 AADPGSDLFSVQALQRRHEGFERDLVPLGD---KVTI-LGETAERLSESHPDATEDLQRQ 1263
A S L S L++R + L+ G+ K+ + +G+ + L S+ + +Q Q
Sbjct: 2647 LACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQ 2706
Query: 1264 KMELNEAWEDLQGRTKDRKESLNEA-QKFYLFLSKARDLQNWISSIGGMVSSQELAEDLT 1322
L E W D+ + + +L ++ ++ + L+ W+ S+ + + +
Sbjct: 2707 LETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI--EHPLQPQP 2764
Query: 1323 GIE---ILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDD 1379
G++ +LL+ Q ++ E L S EL + S + + + D
Sbjct: 2765 GLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDI 2824
Query: 1380 LEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDL 1439
+ A EK +K+ + + M+ + W+ + + L S DS A KK +
Sbjct: 2825 MTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS-SATQKKLSKI 2883
Query: 1440 DKAITAQE---GKITDLEHFAESLIADEHYAKEEIA-TRLQRVLDRWKALKAQLIDERTK 1495
+ I ++E +++ +E A + + + E+ T +Q + WK + + ++
Sbjct: 2884 KELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSC 2943
Query: 1496 LGDYANL-----KQFYRDLEELE---EWISEMLPTACDE-SYKDATNIQRKYLKHQTFAH 1546
L + + ++F + +LE E S +L T + + + N + ++
Sbjct: 2944 LENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQ 3003
Query: 1547 EV-DGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNE 1605
E+ D + +L + L E + ++ L + ++ L + + KG + E
Sbjct: 3004 EILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQAS-KGCQNKE 3062
Query: 1606 ASRQQRFNTSIRDFEFWLSEAE-TLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALK 1664
QQRF + RDF+ WL A+ T D ++++ L+K ++ + E+
Sbjct: 3063 QILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQK---IQEFLSESENGQH 3119
Query: 1665 DLNTLAEDLLSSGTFNVDQIVKKK-DNVNKRFLNVQELAAAHHEKLKEAYALFQ------ 1717
LN +LS G + K+K + + +E H L + + +
Sbjct: 3120 KLNM----MLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQM 3175
Query: 1718 --FFQDLDDEESWIE--EKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVL 1773
F + + W+ EK++ SS DL + +K + + E+ +EP + +
Sbjct: 3176 KDFEVSAEPIQDWLSKTEKMVHESSNRL-YDLPAKRREQQKLQSVLEEIHCYEPQLNRLK 3234
Query: 1774 DMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESL-EYLQFMQNAEEEE 1832
+ A++L + A + + R++Q + L L K + +L+ + E+ QF +E +
Sbjct: 3235 EKAQQLWEGQA-ASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ 3293
Query: 1833 AWINEKNALAVRGDCGDT--LAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVL 1890
W+ + + + C T + S +K EAL + E +++ + +GE +L
Sbjct: 3294 DWMTDAIHM-LDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTS 3352
Query: 1891 QEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVV---EAWIADK 1947
E I +++++ + SL A K QLE A ++ D V W+
Sbjct: 3353 PEGIPT--IQQQLQSVKDMWASLLSAGIRCKSQLEG--ALSKWTSYQDGVRQFSGWMDSM 3408
Query: 1948 ETSL-KTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQH---NQS 2003
E +L ++ A+L D T+L K L+ + S+ L E ++K ++ + +
Sbjct: 3409 EANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSS--LLETIEVKGAGMTEHYVTQLEL 3466
Query: 2004 KAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKME 2063
+ ++ERY A+ +R ++ + S +K L E+ A W + +
Sbjct: 3467 QDLQERYRAIQERAKEAVTKS--------------EKLVRLHQEYQRDLKAFEVWLGQEQ 3512
Query: 2064 ENLSE--------PVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVP 2115
E L + H +L ++++LQ A QA +L + + G+P
Sbjct: 3513 EKLDQYSVLEGDAHTHETTLRDLQELQ-------VHCAEGQALLNSVLHTREDVIPSGIP 3565
Query: 2116 SSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILE 2175
+ +E L + W+ + R E + + V + ++ Q +L+ E
Sbjct: 3566 QAEDR--ALESLRQDWQ----AYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE 3619
Query: 2176 -----TRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILD 2230
TR T E QL K+ +E+ A + ++ ++ + D ++
Sbjct: 3620 KVSPRTRRQ-------SNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVN 3672
Query: 2231 IKY--STIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLT 2288
+ L ++ L L LE++IQ+ + SE +L +S Y
Sbjct: 3673 SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLE---ESESSLSSYSDWYGS------ 3723
Query: 2289 GRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSL----EDYTAFLI 2344
THK F++ ++ + V + E L ++ G S E +L
Sbjct: 3724 ---THKNFKNVATKID-KVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLE 3779
Query: 2345 DKESENIKSSDEIENAFQALAEGKSYITKEDM 2376
+ E+E ++ EI + + L E S + KE M
Sbjct: 3780 EGEAERLRK--EIHDHMEQLKELTSTVRKEHM 3809
Score = 147 bits (370), Expect = 2e-34
Identities = 430/2236 (19%), Positives = 866/2236 (38%), Gaps = 316/2236 (14%)
Query: 133 IEELRHLWDLLLELTLEKGDQ-------LLRALKFQQYVQECADILEWIGDKEAIATSVE 185
++EL L D+ EL + G + L ++++ +Q+ AD+LE +K A +
Sbjct: 6557 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 6616
Query: 186 LGEDWERTEVLHKKFEDFQ---VELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEV 242
+ E ++L K E FQ ++ E ++ +A + + H +L +
Sbjct: 6617 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTEL------MAQA 6670
Query: 243 NAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGL 302
+A +R ++ + L ++L +++++ ++ ++ P + + +D +
Sbjct: 6671 SAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRIT 6730
Query: 303 FHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSD--APQIQEMKEDLVSSW----EHIR 356
+ H L+ +L K+ ++ ++L +S Q+ ++ E +S+ + +
Sbjct: 6731 LYQH--LKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELH 6788
Query: 357 ALAT-----SRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411
L T +RY+ A H S D L W + E+ D L+
Sbjct: 6789 RLETILKHWTRYQSESADL-IHWLQSAKDRLEFWTQQSVTVPQELEMVRDH------LNA 6841
Query: 412 HQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQ 471
+ E+D+ S TG L+ + +R ++ +D+ WT LL +
Sbjct: 6842 FLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEK 6901
Query: 472 YEQCLDFHLFYRDS-EQVDSWMSRQEAFLENED--LGNSLG--SAEALLQKHEDFEEAFT 526
Q L R + +V SW+S E ++ ++ + NS+G + LQK++ F+
Sbjct: 6902 LHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDIN 6961
Query: 527 AQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESL-LLQ 585
++ +TVD ++ D E+ ++ + + A+ + + L+ E + LL+
Sbjct: 6962 CKQ---LTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLE 7018
Query: 586 KLYEDSDD-------LKNWI-NKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQL 637
L E + LK W ++K+L D ++++ ++ Q E + + ++
Sbjct: 7019 GLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEV 7078
Query: 638 ENIQKTGQEMIEG-GHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNA 696
E I++ G +I+ S V + L E+ W L Q L
Sbjct: 7079 EKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSV---------- 7128
Query: 697 EDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFE-- 754
L +W +V + L E + L + LL ++ A Q QVD L +L E
Sbjct: 7129 --LDQWSSH---KVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ 7183
Query: 755 ----------------EIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLI 798
E P ++ + + + R+ L E +A + + LL L
Sbjct: 7184 ERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQR 7243
Query: 799 CRD--------TEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQ 850
+D + +E E +AT+ + D +A+ + +L+ + + + +
Sbjct: 7244 YKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVAT--WIQDCNDLLKGLGTVKDSLF 7301
Query: 851 EITERGNKMVEE-GHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANV-QFQQYLADL 908
+ E G ++ ++ AA + S SL+Q++ +L ++Q L+A V ++ + L
Sbjct: 7302 FLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSL 7361
Query: 909 HEAETWIREKEPIV--DNTNYGAD--------EEAAGALLK-KHEAFLLD-LNSFG---- 952
E WI E E I+ + ++ +D EE G +LK A LD LN G
Sbjct: 7362 EALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP 7421
Query: 953 ---DSMKALRNQANACQQQQAAPVEGVAGEQRVMALY-----------DFQARSPREVTM 998
+K ++N + E + Q + + +F ++ +++ +
Sbjct: 7422 LNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV 7481
Query: 999 K-KGDVLTLLSSIN-KDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQR 1056
+ G+ LL + ++ E Q I+ ++ + D +L Q + ++ +
Sbjct: 7482 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII-----DGQRLLEQGQVDDRDEFNLK 7536
Query: 1057 QEQIENQYRSLLDRAEERRR------RLLQRYNEFLLAYEAGDMLEWIQEKK-------- 1102
+ NQ++ ++ RA++RR R QRY E A + +W+ E
Sbjct: 7537 LTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM-----AEKLRKWLVEVSYLPMSGLG 7591
Query: 1103 -----AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQI 1157
+ D+V +K F Q + + AD E L E A+I
Sbjct: 7592 SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGA-EAALQAELAEI 7650
Query: 1158 RQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFS 1217
+++ S + RL +++++L E + D+ E++ + LS + P
Sbjct: 7651 QEKWKS---ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHH-EE 7706
Query: 1218 VQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKME-LNEAWEDLQG 1276
+ A Q R + E + D +T L + LS + +++E L WE+L
Sbjct: 7707 LHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH 7766
Query: 1277 RTKDRKESLNE-AQKFYLFLSKARDLQNWISSIGGMVSSQE--LAEDLTGIEILLERHQE 1333
+ R++ + E ++ +F K ++L W++ + VS L E++ IE L + +QE
Sbjct: 7767 QLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEM--IEKLKKDYQE 7824
Query: 1334 HRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKR-KKILD 1392
A + Q + + A+ S + EIE KL V L R KK+ +
Sbjct: 7825 EIAIAQENKIQLQQMGERLAKA--SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKE 7882
Query: 1393 QCLELQMFQGNCDQVESWMVARENSLRSD---DKSSLDSLEALMKKRDDLDKAITAQEGK 1449
+ +Q N + +W+ E+ L D + + ++ + ++ +L + I
Sbjct: 7883 TLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7942
Query: 1450 ITDLEHFAESLIAD-EHYAKEEIATRLQ---RVLD-RWKALKAQLIDERTKLGDYANL-K 1503
+ + + E L+ D + A + +Q R LD RW+ + A ++ R K+ + L +
Sbjct: 7943 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 8002
Query: 1504 QFYRDLEELEEWISEMLPTACDES-----YKDATNIQRKYLKHQTFAHEVDGRSEQVHGV 1558
+F D E+W+ TA S Y A +K+ Q HE + E ++
Sbjct: 8003 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
Query: 1559 I-NLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNE-ASRQQRFNTSI 1616
L SAC ++K+ + + + WD+L +R ++L +++ F T+
Sbjct: 8063 YRRLARENRTDSAC-----SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 8117
Query: 1617 RDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSS 1676
WL+E + L + + +K+ + ++E+ + + E +++
Sbjct: 8118 DSILVWLTEMDLQLTNIEHFSE-CDVQAKIKQLKAFQQEISLNHNKI-------EQIIAQ 8169
Query: 1677 GTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRV 1736
G +Q+++K + ++ AA E+L E L ++ Q++ +KLIR+
Sbjct: 8170 G----EQLIEKSEPLD---------AAIIEEELDE---LRRYCQEVFGRVERYHKKLIRL 8213
Query: 1737 SSQDYGRDLQGVQNLLKK---------HKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQ 1787
D DL + L+ H R L++ +P+ L +A+ L+ + +
Sbjct: 8214 PLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS--G 8271
Query: 1788 EEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNAL-AVRGD 1846
+ + W+ +L++ + +L +E+EE ++ L G
Sbjct: 8272 RDTPASVDSIPLEWDHDYDLSRDLESAMSRALP-------SEDEEGQDDKDFYLRGAVGL 8324
Query: 1847 CGDTLAATQSLLMKHEALEND-FAVHETR--VQNVCAQGEDI------LNKVLQEESQN- 1896
GD A + +AL++ F + +T +++ G ++ K+L E S +
Sbjct: 8325 SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSI 8384
Query: 1897 ---KEISSKIEALNEKTPSL----------AKAIAAWKL-----------QLEDDYAFQE 1932
K + K++ E P A I W+L ++ +Q+
Sbjct: 8385 DSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQ 8444
Query: 1933 FNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLK 1992
FN + + AW+ D E L+ L D LQ + + L + D +
Sbjct: 8445 FNSDLNSIWAWLGDTEEELE---------QLQRLELSTDIQTIELQIKKLKELQKAVDHR 8495
Query: 1993 DKLI-----------SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKA 2041
+I A +S+ +++R + + RW+++ R L + + Q
Sbjct: 8496 KAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQG- 8554
Query: 2042 EDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLA---SLARAQAD 2098
F E +H L E ++ +E V S + LQ H+ + L +Q
Sbjct: 8555 ---FHEMSH---GLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLR 8608
Query: 2099 FKCLLELDQQ--IKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNF 2156
L ++ Q + A G + LE K +I R + L KE +R +K
Sbjct: 8609 VASLQDMSCQLLVNAEG----------TDCLEA--KEKVHVIGNRLKLLLKEVSRHIKEL 8656
Query: 2157 EMCQEFEQNASTFLQW 2172
E + + W
Sbjct: 8657 EKLLDVSSSQQDLSSW 8672
Score = 145 bits (365), Expect = 6e-34
Identities = 446/2413 (18%), Positives = 932/2413 (38%), Gaps = 300/2413 (12%)
Query: 30 EVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQG 89
+++ YQ+ K V++ + + +D +DL KW K +K
Sbjct: 2086 DLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDL-KWAFSKHETAKNKMN-------- 2136
Query: 90 KYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLE 149
K + L+ L+SEL+K F++ K +E W + E E
Sbjct: 2137 --YKQKDLDNFTSKGKHLLSELKKIHSSDFSL-------VKTDMESTVDKWLDVSEKLEE 2187
Query: 150 KGDQLLRALKFQQYVQECADILE-WIGD-KEAIATSVELGEDWERTEVLHKKFEDFQVEL 207
D+L +L V D +E W + +A ++ ++ R E L K+FE E+
Sbjct: 2188 NMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFES---EV 2244
Query: 208 VAKEGRVVEVNQYANECAE-----ENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALS- 261
K R+ E++ N+ E E PDL I++ + + + +A K +
Sbjct: 2245 KNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTA 2304
Query: 262 NAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVK 321
+ +++F D+T ++E + + L + + + + N++ + +
Sbjct: 2305 QSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLN 2364
Query: 322 ELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDE 381
LC K H ++ + L+ E + L + LQ + H FS E
Sbjct: 2365 SLCRKY------HSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKH-FSESMQE 2417
Query: 382 LSGW-MNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDL-VNA 439
W + K AA + + D E L Q + + + + GQ L +
Sbjct: 2418 FQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHL 2477
Query: 440 NHEASDEVREKMEILDNNWTALLELWDERHRQYEQCL-DFHLFYRDSEQVDSWMSRQEAF 498
+ + ++E++ + + A L+ + + + C + F +++ W+ E
Sbjct: 2478 SKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER 2537
Query: 499 LENEDLGNS---LGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555
E+LG S + + + K E F A E + + + L + H + +
Sbjct: 2538 FNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRL 2597
Query: 556 IRDGLLARRDALREKAATRRRLLKESLLLQK---LYEDSDDLKNWINK-KKKLADDEDY- 610
L + ++ LR T+ +L + LQ+ L E + W+ + +LA E
Sbjct: 2598 CSQLLTSHQNLLR---MTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTL 2654
Query: 611 --KD-IQNLKSRVQKQQVFEKE------LAVNKTQ--LENIQKTGQEMIEGGHYASDNVT 659
KD ++ S++Q + + E +A+ K + L + K GQ +I+
Sbjct: 2655 GSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQ---------- 2704
Query: 660 TRLSEVASLWEELLEATKQKGTQLHEA-NQQLQFENNAEDLQRWLEDVEWQVTSEDYGKG 718
T+L + +W +++ ++ + L +Q + L++W+E V+ ++ +
Sbjct: 2705 TQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQP 2764
Query: 719 LAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHP--DSKDIRARQESLVCRFE 776
+ + L H L+S ++ +D L L A E+ D QE L +F
Sbjct: 2765 GLKEKFVLLDH--LQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFN 2822
Query: 777 ALKEPLATRKKKLLDLLHLQLICRDTEDEEA-WIQE--------TEPSATSTYLGKDLIA 827
+ + +K+ +++ L+ D E W+ ++ S S+ K L
Sbjct: 2823 DIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSK 2882
Query: 828 SKKLLNRHRV---ILENIASHEPRIQEITERGNKMVEEGHFAA--------EDVASRVKS 876
K+L++ + L + S P +++ T + A ED + +S
Sbjct: 2883 IKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQS 2942
Query: 877 LNQNMESLRARAARRQNDLEANVQ--FQQYLADLHEAETWIRE---------KEPIVDNT 925
+N+ S A + + + A ++ +Q+ A L +TW ++ E IV+
Sbjct: 2943 CLENLVSQMALSEQEFSGQVAQLEQALEQFSALL---KTWAQQLTLLEGKNTDEEIVECW 2999
Query: 926 NYGADEEAAGALLKKHEA-------------FLLDLNSFGDSMKALRNQANACQQQQAAP 972
+ G +E AL K F DL+++ + L + N C QA+
Sbjct: 3000 HKG--QEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYN-CLCLQAS- 3055
Query: 973 VEGVAGEQRVM------ALYDFQAR--SPREVTMKKGDVLTLLSSINKDWWKV-----EA 1019
+G +++++ A DFQ + + T K D+ +S ++ K+ E+
Sbjct: 3056 -KGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSES 3114
Query: 1020 ADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLL 1079
+ Q + + + + ++ + +T +E +N + S L + E L
Sbjct: 3115 ENGQHKLNMMLSKGELLSTL-LTKEKAKGIQAKVTAAKEDWKN-FHSNLHQKESALENLK 3172
Query: 1080 QRYNEFLLAYEAGDMLEWIQ--EKKAENTGVELDDV---WELQKKFDEFQKDLNTNEPRL 1134
+ +F ++ E + +W+ EK + L D+ Q+K ++++ EP+L
Sbjct: 3173 IQMKDFEVSAEP--IQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQL 3230
Query: 1135 RDINKVADDLLFEGLLTPEGAQIR-QELNSRWGSLQRLADEQRQLLGSAHAVEVFHREAD 1193
+ + A L +EG + + R +L+S++ +L L E+ L V ++ +
Sbjct: 3231 NRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLD--RIVAEHNQFSL 3287
Query: 1194 DTKEQIEKKCQALSAAD----PGSD----------LFSVQALQRRHEGFERDLVPLGDKV 1239
KE + A+ D P SD L ++ ++++ E + +V G+ V
Sbjct: 3288 GIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESV 3347
Query: 1240 TILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEA-QKFYLFLSKA 1298
L + P+ +Q+Q + + W L K L A K+ +
Sbjct: 3348 ---------LQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGV 3398
Query: 1299 RDLQNWISSIGGMVSSQELAE-DLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELID 1357
R W+ S+ ++ E +L +L + + ++ + + + +E A + +
Sbjct: 3399 RQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE 3458
Query: 1358 SGHHASPEIEKKLQAVKLERDDLEKAW----EKRKKILDQCLEL----QMFQGNCDQVES 1409
H+ + +LE DL++ + E+ K+ + + +L Q +Q + E
Sbjct: 3459 --HYVT----------QLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEV 3506
Query: 1410 WMVARENSLRSDDKSSLD----SLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEH 1465
W+ + L D S L+ + E ++ +L + + + H E +I
Sbjct: 3507 WLGQEQEKL--DQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGI 3564
Query: 1466 YAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYAN-LKQFYRDLEELEEWISEMLPTAC 1524
E+ A L+ + W+A + +L + RT+ + N L+ + ++++EW+
Sbjct: 3565 PQAEDRA--LESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVS 3622
Query: 1525 DESYKDATNIQRKYLKHQT--FAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQL 1582
+ + + ++ HQ + EV ++V V +++ S + M Q
Sbjct: 3623 PRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSR---MGCQA 3679
Query: 1583 EQLKEHWDHLLERTNDKGKKLNEASRQ-QRFNTSIRDFEFWLSEAETL---LAMKDQARD 1638
QL + LL + ++ K L E + + +S+ + W +A K D
Sbjct: 3680 TQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVD 3739
Query: 1639 LASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNV 1698
G LK ++L ++M LK E + + + + ++ +
Sbjct: 3740 TVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKY--LEEGEAERLRKEIHDHMEQL 3797
Query: 1699 QELAAA---HHEKLKEAYALFQFFQDLDDE-ESWIEE--KLIRVSSQDYGRDLQGVQNLL 1752
+EL + H L++ L + F D WI E +++ V + +L + L
Sbjct: 3798 KELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPK-MELYEKKAQL 3856
Query: 1753 KKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARG 1812
K+K L+ +++HEP++++V + E L + V ++ ++ Q ++ L + K
Sbjct: 3857 SKYKSLQQTVLSHEPSVKSVREKGEALLE--LVQDVTLKDKIDQLQSDYQDLCSIGKEHV 3914
Query: 1813 LKLEESL-EYLQFMQNAEEEEAWINEKNALAVRGDCGDT--LAATQSLLMKHEALENDFA 1869
LE + ++ + +E E W+ + + V D +T L L H+A+ + A
Sbjct: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIA 3974
Query: 1870 VHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAI--AAWKLQLEDD 1927
E R+ N+ +G+ ++ + + ++ + A + T AI A ++ +
Sbjct: 3975 GFEDRLNNLQMKGDTLIGQC--ADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLE 4032
Query: 1928 YAFQEFNWKADVV---EAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQ--Q 1982
+ Q+ + D + +AW++ + L+ + L++ + + ++ F+ Q
Sbjct: 4033 HELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPP--------LSRAEAI-KQVKHFRALQ 4083
Query: 1983 ERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLE--KQLPLQK 2040
E+ D L+ + + S A + A +++ EQ +E V Q L + +++ K
Sbjct: 4084 EQARTYLD----LLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLK 4139
Query: 2041 AEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFK 2100
+E L++ L N + E + LN + + +DF+ L QA
Sbjct: 4140 SE-LWIYLQDADQQLQNMKRRHSE--------LELNIAQNMVSQVKDFVKKLQSKQASVN 4190
Query: 2101 CLLELDQQIKALGVPSSPYTWLTVEVLERTWKHL----SDIIEEREQELQKEEARQVKNF 2156
++E ++ L + L W L +++ +RE++LQ+ +++
Sbjct: 4191 TIIE---KVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR-----TRDY 4242
Query: 2157 EMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKI 2216
C ++ LE D + + LEA K+ +Q K + +
Sbjct: 4243 HDCM-------NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDL 4295
Query: 2217 VDLGDNLEDALILD----IKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEET 2272
D + + L LD +K T L Q+W QL L ++++IQ VS
Sbjct: 4296 KDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL-------IKRKIQ------VSVTN 4342
Query: 2273 LKEFSTIYKHFDE 2285
L+E + + F E
Sbjct: 4343 LEELNVVQSRFQE 4355
Score = 134 bits (337), Expect = 1e-30
Identities = 446/2355 (18%), Positives = 873/2355 (37%), Gaps = 348/2355 (14%)
Query: 2 EQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRD 61
E P E + S VL AE + R + + Q +E++ ++ ++ LQ ++ +
Sbjct: 6034 EADPAEQLALQSTLTVL--AERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCE 6091
Query: 62 ADDLGKWIME-KVNILTDKS-YEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERF 119
AD+L W++ K + T S ++P +++ + Q++ E++ K +SEL E
Sbjct: 6092 ADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL 6151
Query: 120 TMGHS-AHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQE---------CAD 169
G + +E + +LR L LLEL D+ L Q +E
Sbjct: 6152 LEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPG 6211
Query: 170 ILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQ-VELVAKEGRVVEVNQYANECAEE- 227
+ EW+ T ++ E+ + E + VA G + + A E + +
Sbjct: 6212 VQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 6271
Query: 228 -NHPDLPLIQ---------SKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAI 277
PD+ L Q S ++++ WE L +QK L N
Sbjct: 6272 GEKPDV-LSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLE------------ 6318
Query: 278 QWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSD 337
+E+E VL S L++ L+ + AV S
Sbjct: 6319 ---QEQEQVLYSRP--NRLLSGVPLYKGDVPTQDKSAVTS-------------------- 6353
Query: 338 APQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNE------KTA 391
+ + L ++E + + S K Q+ + + S W+++
Sbjct: 6354 ------LLDGLNQAFEEVS--SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
Query: 392 AINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKM 451
A+ +E T + E+L ++ E+D + F A N + D + + +
Sbjct: 6406 ALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQA-------FPENGDNRDVIEDTL 6458
Query: 452 EILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSA 511
L + L + ++R Q ++ L L +++ +V ++ + L N
Sbjct: 6459 GCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQP 6518
Query: 512 EA----LLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDAL 567
A +Q+ ED + F A II + + KL + E K L D L
Sbjct: 6519 VAEQIEAIQQAEDGLKEFDA---GIIELKRRGDKLQVEQPSMQELSK-----LQDMYDEL 6570
Query: 568 REKAATRRRLLKESLLLQKLYEDS-DDLKNWINK-KKKLADDE-----DYKDIQNLKSRV 620
+RR L ++L L+ YE + DL + + ++K+A D+ ++IQ L +
Sbjct: 6571 MMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKH 6630
Query: 621 QKQ-QVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQK 679
++ Q E + + +T I +A T +E+ + +L+ ++
Sbjct: 6631 KEYFQGLESHMILTETLFRKIIS----------FAVQKETQFHTELMAQASAVLKRAHKR 6680
Query: 680 GTQL-HEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAE-----VQNRLRKHGLLE 733
G +L + + + ++L R LE VE + S GL E + +R+ + L+
Sbjct: 6681 GVELEYILETWSHLDEDQQELSRQLEVVESSIPS----VGLVEENEDRLIDRITLYQHLK 6736
Query: 734 SAVAARQDQV-DIL------------TDLAAYFEEIGHPDSKDIRARQESLVCRFEALKE 780
S++ Q ++ +L +DL + ++G + + L R E + +
Sbjct: 6737 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKEL-HRLETILK 6795
Query: 781 PLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILE 840
+ + DL+H +D E W Q+ S + ++L + LN +
Sbjct: 6796 HWTRYQSESADLIHWLQSAKDR--LEFWTQQ------SVTVPQELEMVRDHLNAFLEFSK 6847
Query: 841 NIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQ 900
+ + + GN+++ + S + ++ L Q L +Q
Sbjct: 6848 EVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLH-QLQ 6906
Query: 901 FQQYLA--DLHEAETWIREKEPIV----DNTNYGADEEAAGALLKKHEAFLLDLNSFGDS 954
+ + + E +WI E ++ DN +A L+K++ F +D+N
Sbjct: 6907 MDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDIN----- 6961
Query: 955 MKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDW 1014
C+Q V Q V+ + S R K D L ++NK W
Sbjct: 6962 ----------CKQLTVDFV-----NQSVLQISSQDVESKRS---DKTDFAEQLGAMNKSW 7003
Query: 1015 WKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEER 1074
+ QG+V ++ +L + + + EN + L E +
Sbjct: 7004 QIL-----QGLVT---------EKIQLLE--------GLLESWSEYENNVQCLKTWFETQ 7041
Query: 1075 RRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTN---- 1130
+RL Q+ + GD + +N + D+ +L K ++ + + N
Sbjct: 7042 EKRLKQQ-------HRIGD------QASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL 7088
Query: 1131 -EPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSA------- 1182
+ + D++ + L +EL W +L + + + LL S
Sbjct: 7089 IQNKKEDVSSIVMSTL-------------RELGQTWANLDHMVGQLKILLKSVLDQWSSH 7135
Query: 1183 ----HAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDK 1238
+ + EA + + +L A D ++Q LQ E ER L G
Sbjct: 7136 KVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD--NLQNLQDDLEKQERSLQKFG-- 7191
Query: 1239 VTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKA 1298
T + L E HP TE L E+N W +L ++ E L ++ +
Sbjct: 7192 ----SITNQLLKECHPPVTETLTNTLKEVNMRWNNL---LEEIAEQLQSSKALLQLWQRY 7244
Query: 1299 RDLQNWISSIGGMVS--SQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELI 1356
+D +S + EL + T +I + D ++D L
Sbjct: 7245 KDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLH 7304
Query: 1357 DSGHHASPEIE----KKLQAVKLERDD----LEKAWEKRKKILDQ-CLELQMFQGNCDQV 1407
+ G +++ +Q+ +L LE+A K++ L L+ + F + + +
Sbjct: 7305 ELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEAL 7364
Query: 1408 ESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYA 1467
E+W+V E L+ D S L + ++ ++L + DL+ E +
Sbjct: 7365 EAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE--LGYRLPL 7422
Query: 1468 KEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDES 1527
++ R+Q + W + +Q + +KL + L Q LE+ E W+ ++ T +
Sbjct: 7423 NDKEIKRMQNLNRHWSLISSQTTERFSKLQSF--LLQHQTFLEKCETWMEFLVQTEQKLA 7480
Query: 1528 YKDATNIQ---RKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQ 1584
+ + N Q + H+ F E+ R + +H +I G L+E D +E +L
Sbjct: 7481 VEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE-FNLKLTL 7539
Query: 1585 LKEHWDHLLERTNDKGKKLNEASRQ-QRFNTSIRDFEFWLSEAETL--LAMKDQARDLAS 1641
L W ++ R + ++ RQ QR+ WL E L + L
Sbjct: 7540 LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ 7599
Query: 1642 AGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQEL 1701
A L + Q E+ L ++ + + LL S + ++ + +QE
Sbjct: 7600 ARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAE------LAEIQEK 7653
Query: 1702 AAAHHEKLKEAYALFQF-FQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEG 1760
+ +L+E F +D + E I + L ++ + + + L Q+L H+ L
Sbjct: 7654 WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKL--RTFKKKLS--QSLPDHHEELHA 7709
Query: 1761 ELVAHEPAIQNV------LDMAEKLKD--KAAVGQEEIQL---RLAQFVEHWEKLKELAK 1809
E + + V L LKD A + ++I + R+ WE+L
Sbjct: 7710 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7769
Query: 1810 ARGLKLEESL-EYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDF 1868
R ++ E L E+ F + +E W+ + + + GD L +K + E
Sbjct: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN--GDILIEEMIEKLKKDYQEEIA 7827
Query: 1869 AVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDD- 1927
E ++Q + GE + ES+ EI K+ +N++ L IAA +L++
Sbjct: 7828 IAQENKIQ-LQQMGERLAK--ASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETL 7884
Query: 1928 YAFQEFNWKADVVEAWIADKETSLKTN--GNGADLGDFLTLLAKQDTLDASLQSFQQERL 1985
A Q+ + + W+A E+ L + + + L +Q L ++ +
Sbjct: 7885 VAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEK-HSTGV 7943
Query: 1986 PEITDLKDKLI-----SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQK 2040
+ +L + L+ A + +I++ L +RW + S +E++L +++
Sbjct: 7944 ASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMS-------MERRLKIEE 7996
Query: 2041 AEDLFVEFAHKASALNNWCEKMEENLSEP-----VHCVSLNEIRQLQKDHEDFLASLARA 2095
L+ +F S +W + E + P ++ V+ E+++ + A
Sbjct: 7997 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFE----------AFQ 8046
Query: 2096 QADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQ---ELQKEEA-- 2150
+ +CL +L+ + + Y L E + L ++ E Q LQK
Sbjct: 8047 RQVHECLTQLE-------LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSI 8099
Query: 2151 -RQVKNF-EMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQA 2208
R++K+F +EFE + L W+ E + E ++++++ K Q+EI
Sbjct: 8100 LRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC-DVQAKIKQLKAFQQEISL 8158
Query: 2209 MKRQLTKIVDLGDNL 2223
++ +I+ G+ L
Sbjct: 8159 NHNKIEQIIAQGEQL 8173
Score = 124 bits (310), Expect = 1e-27
Identities = 463/2512 (18%), Positives = 946/2512 (37%), Gaps = 322/2512 (12%)
Query: 18 LETAEEIQERRQEVLTRYQSFKERVAERGQ-KLEDSYHLQVFKRDADDLGKWIMEKVNIL 76
L+ E ++E+ + R+ ++ + + Q + + L V + +L +W E+ +
Sbjct: 4308 LDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNI 4367
Query: 77 TD--KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFT-MGHSAHEETKAHI 133
+ K P Q H ++ +E++ K L+ L K + +G + + + +
Sbjct: 4368 AEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKAL 4427
Query: 134 EELRHLWDLLLELTLEKGDQLLRAL----KFQQYVQECADILEWIGDKEAIATSVELGED 189
+ + + L +L ++ L +AL +F V + ++ K + L D
Sbjct: 4428 SDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPD 4487
Query: 190 WERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEE-NHPDLPLIQSKQNEVNAAWER 248
+V K + Q L + V + E +E + + K E+ + ++
Sbjct: 4488 DVSKQV--KTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDS 4545
Query: 249 -LRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHK 307
L+ + + Q+ N + + FK D +A W+K+ + V E +L+ H+
Sbjct: 4546 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEI---NLMNESSELHTQL 4602
Query: 308 GLERNLAVMSDKVKELCAKAEK-----LTLSHPSDAPQIQEMKEDLVSSWEHIRALATSR 362
+N+ S + + L ++ L + D + E L + I ALA +
Sbjct: 4603 AKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDK 4662
Query: 363 YEKLQATYWYHRFSSDFDELSGWMNEKTAA--INADELPTDVA---------GGEVLLDR 411
+ K+Q + + EL+ + A + ++PTD+A G +LD
Sbjct: 4663 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDE 4722
Query: 412 HQQHKHEIDSYDDRFQSADETGQD--------LVNANHEASDEVREKMEILDNNWTALLE 463
+D + + + TGQ LV H + +++ +L++ +A E
Sbjct: 4723 VAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQE 4782
Query: 464 LWDERHRQYEQCLDFHLFYRDSEQV---DSWMSRQEAFLENEDLGNSLGSAEALLQKHED 520
H + Q L+ L EQ + + +E L SL + +L++
Sbjct: 4783 -----HEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTI 4837
Query: 521 FEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKE 580
E + + +K I++ + L A+ E + +
Sbjct: 4838 HLEDLAPHLDPL-AYEKAR-----------HQIQSWQGELKLLTSAIGETVTECESRMVQ 4885
Query: 581 SLLLQKLYEDSDDLKNWINKKKKLADDEDYKDI--QNLKSRVQKQQVFEKELAVNKTQLE 638
S+ Q S D W+ + K Y D+ Q+++ ++K Q+ ++E+ + +
Sbjct: 4886 SIDFQTEMSRSLD---WLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMN 4942
Query: 639 NIQ-KTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FENNA 696
+ K ++ + S ++ L+E++ L ++ EA + + L E Q Q +
Sbjct: 4943 ALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVF 5002
Query: 697 EDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEI 756
+ WLED + + G + + L+ H S ++ L L A + +
Sbjct: 5003 QAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPL 5062
Query: 757 GHPDSK-DIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEA--WIQETE 813
P K D+ + SL R + + + LL Q EE + +TE
Sbjct: 5063 IKPTGKEDLEQKVASLELRSQRMSRDSGAQVD-LLQRCTAQWHDYQKAREEVIELMNDTE 5121
Query: 814 PSATSTYLGKDLIA--SKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVA 871
+ L K + +++ L+ H+ ++ + S +I + E+ +++ + G+ A++
Sbjct: 5122 KKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATL 5181
Query: 872 SR-VKSLNQNMESLRARAARRQNDLEANVQ----FQQYLADLHEAETWIREKEPIVDNTN 926
SR + ++ Q LRA A ++ LE V F + E +++K P
Sbjct: 5182 SRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLP------ 5235
Query: 927 YGADEEAAG-----ALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEG------ 975
G+ E A LL+ H+ F+L+L ++ LR Q + Q AAP G
Sbjct: 5236 -GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLM 5294
Query: 976 ---VAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINK-DWWKVEAADHQGIVPAVYV 1031
A + R + + + + + V + D + + IN W E ++ G
Sbjct: 5295 QEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEID 5354
Query: 1032 RRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLD-RAEERRRRLLQRYNEFLLAYE 1090
+L +E +L NI + E+ + +Y L E +L + + + +
Sbjct: 5355 AQL--EELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQ 5412
Query: 1091 AGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLR-DINKVADDLLFEGL 1149
D ++ +++ KA + EL ++ + KDL T +L+ + V + +
Sbjct: 5413 IQDKIKEVEQSKATSQ--------ELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
Query: 1150 LTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHA------VEVFHREADDTKEQIEKKC 1203
L E +L ++Q+ ++ Q LG A E+ + + ++ K
Sbjct: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQ-LGKPLAKKIGKLTELHQQTIRQAENRLSKLN 5523
Query: 1204 QALSAADPGSDLFSV-------------------QALQRR-----HEGFERDLVPLGDKV 1239
QA S + +++ + A Q R H+ + + ++
Sbjct: 5524 QAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSEL 5583
Query: 1240 TILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQK-FYLFLSKA 1298
+ E + L+ + TE + +Q EL E+L+ K R ++L +A K F ++
Sbjct: 5584 EAMTEKLQYLTSVY--CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAEL 5641
Query: 1299 RDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDS 1358
+ LQ + ++S E+ ++ L Q ++ME+ P QA+ +L S
Sbjct: 5642 KKLQAALEQAQATLTSPEVGR--LSLKEQLSHRQHLLSEMESLKPKVQAV-----QLCQS 5694
Query: 1359 GHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSL 1418
++ L E+A + + QC +Q +Q E M + +
Sbjct: 5695 ALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLI 5754
Query: 1419 RS-----DDK----SSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESL-IADEHYAK 1468
+DK S++ L+A + + ++L + I + +I L + L + +H
Sbjct: 5755 EGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATM 5814
Query: 1469 EEIATRLQRVLDRWKALKAQLIDERT--------KLGDYANLKQFYRDLEELEEWISEM- 1519
T ++ + + + L +L+ + G L + E SE+
Sbjct: 5815 LLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEIS 5874
Query: 1520 LPTACDE----SYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNE 1575
P AC + DA+ Q A + + ++H + E G E
Sbjct: 5875 SPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYE----PGLE 5930
Query: 1576 EAMKEQLEQLKEHWDHLLERTNDKGKKLNEA-SRQQRFNTSIRDFEFWLSEAETLLAMKD 1634
+ +L L+ W+ L ++K + L EA RQQ++ S++ + E L + +
Sbjct: 5931 PSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIE--LKLSE 5988
Query: 1635 QARDLASAGNLLKKHQLLEREMLAREDALKDL-NTLAEDLLSSG---------------T 1678
S + + +HQ L E+L +D + +L ++LAE+L+S T
Sbjct: 5989 SPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLT 6048
Query: 1679 FNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESW---------- 1728
+++ + + + ++E E+ ++ AL ++ + D+ +SW
Sbjct: 6049 VLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDT 6108
Query: 1729 ------------------------IEEKLIRVSSQDYGRD---LQG-------VQNLLKK 1754
IE+K++ +S + L+G + L K
Sbjct: 6109 ALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK 6168
Query: 1755 HKRLEGELVAHEPAIQN--------VLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKE 1806
+RL+G L+ + A+ + + E D A +Q LAQ W + ++
Sbjct: 6169 LRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQ 6228
Query: 1807 LAKARGLKLEESL-EYLQFMQN-AEEEEAWINEKNALAVRGDC--------------GDT 1850
+ + +LE+ L E +++ A E + + +A GD G+
Sbjct: 6229 SSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEK 6288
Query: 1851 LAATQSLLMKHEALENDFAVHETRVQNVCAQGEDIL-----NKVL--------QEESQNK 1897
+A + MK E+L +F+ + +QNV Q ++ + N++L +Q+K
Sbjct: 6289 SSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDK 6348
Query: 1898 E-ISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGN 1956
++S ++ LN+ ++ K Q + Q+ W+ D E L
Sbjct: 6349 SAVTSLLDGLNQAFEEVSSQSGGAKRQ--SIHLEQKLYDGVSATSTWLDDVEERLFV-AT 6405
Query: 1957 GADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKR 2016
+ T L Q+ L ++ +E + + +L + + IE+ LL R
Sbjct: 6406 ALLPEETETCLFNQEILAKDIKEMSEE-MDKNKNLFSQAFPENGDNRDVIEDTLGCLLGR 6464
Query: 2017 WEQLLEASAVHRQKLLEKQLP--LQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVS 2074
LL++ R ++++L L DL V F A +K+ +PV
Sbjct: 6465 L-SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQ 6522
Query: 2075 LNEIRQLQKDHEDFLASLA-------RAQADFKCLLEL-------DQQIKALGVPSSPYT 2120
+ I+Q + ++F A + + Q + + EL D+ + +G S
Sbjct: 6523 IEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLN 6582
Query: 2121 W-LTVE-VLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRA 2178
LT++ ER + L+D++E ++++ ++ V + E Q+ + Q LE+
Sbjct: 6583 QNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQG-LESH- 6640
Query: 2179 YFLDGSLLKETGTLESQLEANKRKQKEIQA---MKRQLTKIVDLGDNLEDALILDIKYST 2235
L +L ++ + Q E + QA +KR + V+L LE LD
Sbjct: 6641 MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQE 6700
Query: 2236 IGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENL 2287
+ R +E I + + +E+ L + T+Y+H +L
Sbjct: 6701 LS-------------RQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSL 6739
Score = 121 bits (304), Expect = 7e-27
Identities = 247/1260 (19%), Positives = 512/1260 (40%), Gaps = 157/1260 (12%)
Query: 1090 EAGDMLEWIQEKK---------AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKV 1140
E+ D++ W+Q K + EL+ V + F EF K+++ +
Sbjct: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 6862
Query: 1141 ADDLLFEGLLTPEGAQIRQELN---SRWGSL--------QRLADEQRQLLGSAHAVE--- 1186
+ LL L + A +R EL+ S+W L ++L Q L S HA+
Sbjct: 6863 GNQLL--RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVM 6920
Query: 1187 --------VFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDK 1238
V ++ D+ K I K ++ ++++GF+ D+
Sbjct: 6921 SWISLMENVIQKDEDNIKNSIGYK--------------AIHEYLQKYKGFKIDINCKQLT 6966
Query: 1239 VTILGETAERLS----ESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNE-AQKFYL 1293
V + ++ ++S ES D Q +N++W+ LQG ++ + L + +
Sbjct: 6967 VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSE 7026
Query: 1294 FLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSA 1353
+ + + L+ W + + Q D ++ L+ Q+ ++A+ + +E
Sbjct: 7027 YENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGL 7086
Query: 1354 ELI-DSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCL-ELQMFQGNCDQVESWM 1411
LI + S + L+ + +L+ + K +L L + + D++ S++
Sbjct: 7087 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYL 7146
Query: 1412 VARENSLRSDDKSSLDSLEALMKKRDDLDKA---ITAQEGKITDLEHFAESLIADEH-YA 1467
+ SL S + SLEA+ + D+L + QE + L+ + H
Sbjct: 7147 MEARYSL-SRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPV 7205
Query: 1468 KEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDES 1527
E + L+ V RW L ++ ++ L Q Y+D + + +E
Sbjct: 7206 TETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL 7265
Query: 1528 YKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKE 1587
K ATN K + A + ++ + G+ + +SL + E EQLK+
Sbjct: 7266 LKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLF----------FLHELGEQLKQ 7312
Query: 1588 HWD----------------HL--LERTNDKGKKLNEAS--RQQRFNTSIRDFEFWLSEAE 1627
D HL LE+ K + +A + F S+ E W+ EAE
Sbjct: 7313 QVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE 7372
Query: 1628 TLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKK 1687
+L +D + + + ++ + L+ +ML DL+ L E L D+ +K+
Sbjct: 7373 EILQGQDPSHS-SDLSTIQERMEELKGQMLKFSSMAPDLDRLNE--LGYRLPLNDKEIKR 7429
Query: 1688 KDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQG 1747
N+N+ + + KL+ Q F L+ E+W+E + + Q ++ G
Sbjct: 7430 MQNLNRHWSLISSQTTERFSKLQSFLLQHQTF--LEKCETWME--FLVQTEQKLAVEISG 7485
Query: 1748 -VQNLLKK---HKRLEGELVAHEPAIQNVLDMAEKLKDKAAV-GQEEIQLRLAQFVEHWE 1802
Q+LL++ H+ + E+ + + + +++ ++L ++ V ++E L+L W+
Sbjct: 7486 NYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQ 7545
Query: 1803 -KLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVR--GDCGDTLAATQSLLM 1859
++ + RG+ + ++ ++ + AE+ W+ E + L + G L ++L
Sbjct: 7546 GVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFD 7605
Query: 1860 KHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAA 1919
+ + E F + G+ +L + + + +++ + EK S + +
Sbjct: 7606 EVQFKEKVFLRQQGSYILTVEAGKQLL--LSADSGAEAALQAELAEIQEKWKSASMRLEE 7663
Query: 1920 WKLQLEDDYAFQEFNWKADVVEAWIADKETSLKT--NGNGADLGDFLTLLAKQD----TL 1973
K +L AF +W + E IAD L+T L D L + L
Sbjct: 7664 QKKKL----AFLLKDW--EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKEL 7717
Query: 1974 DASLQSFQQERLPEITDLKDKL---ISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQK 2030
+ ++ S+ + L +++ LKD L ISA + + ER L ++WE+L ++ RQ+
Sbjct: 7718 ENAVGSWTDD-LTQLSLLKDTLSAYISA--DDISILNERVELLQRQWEELCHQLSLRRQQ 7774
Query: 2031 LLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLA 2090
+ E+ + + F+ K L W +ME +S+ + I +L+KD+++
Sbjct: 7775 IGERL-------NEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQE--- 7824
Query: 2091 SLARAQADFKCLLELDQQIKALGVPS--SPYTWLTVEVLERTWKHLSDIIEEREQELQKE 2148
+A AQ + L ++ +++ S S + +V +R W+HL D+I R ++L+
Sbjct: 7825 EIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDR-WQHLLDLIAARVKKLK-- 7881
Query: 2149 EARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRK--QKEI 2206
+ Q+ ++N S+ W+ + + + E Q + N+++ Q++I
Sbjct: 7882 -----ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 7936
Query: 2207 QAMKRQLTKIVDLGDNL--------EDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQ 2258
+ + +++L + L DA I+ +T L ++W + + + + +E+
Sbjct: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
Score = 107 bits (266), Expect = 2e-22
Identities = 440/2253 (19%), Positives = 874/2253 (38%), Gaps = 330/2253 (14%)
Query: 54 HLQVFKRDADDLGKWIMEKVNILTDKS--YEDPTNIQGKYQKHQSLEAEVQTKSRLMSEL 111
HL+ + + + KWI EK +L + + + ++ +Y HQ+L ++ + SEL
Sbjct: 5528 HLEEYNEMLELILKWI-EKAKVLAHGTIAWNSASQLREQYILHQTL---LEESKEIDSEL 5583
Query: 112 EKTREE-RFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALK-FQQYVQECAD 169
E E+ ++ E+ + EL + L ++ + L A K +++ E
Sbjct: 5584 EAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKK 5643
Query: 170 ILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENH 229
+ + +A TS E+G + ++ H++ ++E + + + V++ Q A E+
Sbjct: 5644 LQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVV 5703
Query: 230 PDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAA-NLQRFKRDVTEAIQWIK------E 282
LPL + A RL+ A+Q+ + A +++++++ Q I+ E
Sbjct: 5704 ASLPLCHAALRLQEEA-SRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIE 5762
Query: 283 KEPVLTS--EDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLT-LSHPSDAP 339
+PV TS ++ + E L KG + +A ++ K K L KA+ T L ++
Sbjct: 5763 DKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVE 5822
Query: 340 QIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSG--WMNEKTAAINADE 397
+ E EDL E + + + H S E SG N + ++ A
Sbjct: 5823 GLAEGTEDL--DGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR 5880
Query: 398 LPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVRE-------- 449
P+ VA + +++ +I Y +T ++ + AS E E
Sbjct: 5881 SPSPVANTDASVNQ------DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT 5934
Query: 450 -KMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAF-LENEDLGNS 507
K+ L +W L + E+ R + L+ Y+DS Q S ++ EA L+ +
Sbjct: 5935 AKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQ--SISTKMEAIELKLSESPEP 5992
Query: 508 LGSAEALLQKHEDF-EEAFTAQEEKIITVDKTATKLIGD----DHYDSENIKAIRDGLLA 562
S E+ + +H+ +E Q+E A +L+ + D + +++ L
Sbjct: 5993 GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE 6052
Query: 563 RRDALREKAATRRRLLKESL-----------LLQKLYEDSDDLKNWINKKKKLAD----- 606
R +R KA+ +R+LL+E L LQ+ ++D+L +W+ K D
Sbjct: 6053 RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP 6112
Query: 607 -------DEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVT 659
+ D QN+ ++++ V EL+V+ L ++EG + D
Sbjct: 6113 PKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENL---------LLEGKAHTKDEAE 6163
Query: 660 TRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVT-SEDYGKG 718
++ L LLE + LH+ +QL + A++ + DV+ T S +
Sbjct: 6164 QLAGKLRRLKGSLLELQRA----LHD--KQLNMQGTAQEKEE--SDVDLTATQSPGVQEW 6215
Query: 719 LAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEAL 778
LA+ + + ++ Q Q ++ +LA + + + +R E ++ + A
Sbjct: 6216 LAQARTTWT-----QQRQSSLQQQKELEQELAEQKSLL-----RSVASRGEEILIQHSAA 6265
Query: 779 KEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVI 838
+ +K D+L +L E E S+ + + + + + +
Sbjct: 6266 ETSGDAGEKP--DVLSQELG-----------MEGEKSSAEDQMRMKWESLHQEFSTKQKL 6312
Query: 839 LENIASHEPRIQEITERGNKMVE-----EGHFAAED---VASRVKSLNQNMESLRARA-- 888
L+N+ E Q + R N+++ +G +D V S + LNQ E + +++
Sbjct: 6313 LQNVLEQEQE-QVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGG 6371
Query: 889 ARRQNDLEANVQFQQYLAD-LHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLD 947
A+RQ+ + +Q L D + TW+ + E + EE L + E D
Sbjct: 6372 AKRQS-----IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQ-EILAKD 6425
Query: 948 LNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLL 1007
+ + M +N + QA P G R E T+ G +L L
Sbjct: 6426 IKEMSEEMDKNKNLFS-----QAFPENG-------------DNRDVIEDTL--GCLLGRL 6465
Query: 1008 SSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSL 1067
S ++ V + H + +E I Q ++ + SL
Sbjct: 6466 SLLDS-----------------VVNQRCH--------QMKERLQQILNFQNDLKVLFTSL 6500
Query: 1068 LDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELD-DVWELQKKFDEFQKD 1126
D ++L + + + +E IQ+ AE+ E D + EL+++ D+ Q +
Sbjct: 6501 ADNKYIILQKLANVFEQ-----PVAEQIEAIQQ--AEDGLKEFDAGIIELKRRGDKLQVE 6553
Query: 1127 LNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVE 1186
+P +++++K+ D +++ L+ G++ R LN +L + +R L A +E
Sbjct: 6554 ----QPSMQELSKLQD--MYDELMMIIGSR-RSGLNQ---NLTLKSQYERALQDLADLLE 6603
Query: 1187 VFHRE-ADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKV--TILG 1243
+ A D K + K + D + F +G E ++ L + + I+
Sbjct: 6604 TGQEKMAGDQKIIVSSKEEIQQLLDKHKEYF---------QGLESHMI-LTETLFRKIIS 6653
Query: 1244 ETAERLSESHPD----ATEDLQR---QKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLS 1296
++ ++ H + A+ L+R + +EL E +D++E + +
Sbjct: 6654 FAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEV------ 6707
Query: 1297 KARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELI 1356
+++ I S+G + +++ D I L +H + + E + +Q L+D LI
Sbjct: 6708 ----VESSIPSVGLVEENEDRLID----RITLYQHLKSSLN-EYQPKLYQVLDDGKRLLI 6758
Query: 1357 D-SGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARE 1415
S ++ + + + + K + + IL +Q + W+ + +
Sbjct: 6759 SISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR---YQSESADLIHWLQSAK 6815
Query: 1416 NSLRSDDKSSLDSLEALMKKRDDLD------KAITAQEGKITDLEHFAESLIADEHYAKE 1469
+ L + S+ + L RD L+ K + AQ + + L+ +
Sbjct: 6816 DRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTA 6875
Query: 1470 EIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRD-LEELEEWISEMLPTACDESY 1528
+ + L R+ +W L + + KL K R + E+ WIS M
Sbjct: 6876 TLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVI----Q 6931
Query: 1529 KDATNIQR--------KYL-KHQTFAHEVDGRSEQV----HGVINLGNSLIECSACDGNE 1575
KD NI+ +YL K++ F +++ + V V+ + + +E D +
Sbjct: 6932 KDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTD 6991
Query: 1576 EAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQ-QRFNTSIRDFEFWLSEAETLLAMKD 1634
A EQL + + W L +K + L + +++ + W E L +
Sbjct: 6992 FA--EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH 7049
Query: 1635 QARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK-DNVNK 1693
+ D AS N LK Q LE + A+E ++ + L+ + +V IV + +
Sbjct: 7050 RIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQ 7109
Query: 1694 RFLNVQELAAAHHEKLKEAYALFQFFQ-DLDDEESWIEEKLIRVSS-QDYGRDLQGVQNL 1751
+ N+ + LK + + D S++ E +S + L+ VQ
Sbjct: 7110 TWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQ 7169
Query: 1752 LKKHKRLEGELVAHEPAIQNVLDMAEK-LKDKAAVGQEEIQLRLAQFVEHWEK-LKELAK 1809
+ + L+ +L E ++Q + + LK+ E + L + W L+E+A+
Sbjct: 7170 VDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAE 7229
Query: 1810 ARGLKLEESLEYLQFMQ-----------NAEEEEAWINEKNALAVRGDCGDTLAATQ--- 1855
+L+ S LQ Q +++E NE A D D AT
Sbjct: 7230 ----QLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQD 7285
Query: 1856 -SLLMKHEALEND--FAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPS 1912
+ L+K D F +HE GE + +V + S I S +L++ +
Sbjct: 7286 CNDLLKGLGTVKDSLFFLHEL--------GEQLKQQV--DASAASAIQSDQLSLSQHLCA 7335
Query: 1913 LAKAIAAWKLQLEDDYA-FQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQD 1971
L +A+ + L+ ++ F + +EAWI + E L+ + + D T+ + +
Sbjct: 7336 LEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQ-GQDPSHSSDLSTIQERME 7394
Query: 1972 TLDASLQSFQQ-----ERLPEI---TDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEA 2023
L + F +RL E+ L DK I N + R+ +L+ Q E
Sbjct: 7395 ELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLN-----RHWSLIS--SQTTER 7447
Query: 2024 SAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQK 2083
+ + LL+ Q L+K E ++EF + +K+ +S + + + Q+
Sbjct: 7448 FSKLQSFLLQHQTFLEKCE-TWMEFLVQTE------QKLAVEISG-----NYQHLLEQQR 7495
Query: 2084 DHEDFLASL-ARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEERE 2142
HE F A + +R Q +++ + ++ V L + +L W+ + ++R
Sbjct: 7496 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 7555
Query: 2143 QELQKEEARQVKNFEMCQEFEQNASTFLQWILE 2175
+ + Q + + A +W++E
Sbjct: 7556 GIIDSQ-------IRQWQRYREMAEKLRKWLVE 7581
Score = 95.1 bits (235), Expect = 7e-19
Identities = 322/1712 (18%), Positives = 637/1712 (37%), Gaps = 254/1712 (14%)
Query: 83 DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHI----EELRH 138
D ++Q + Q LE ++ K + E+EK + + + E+ + + EL
Sbjct: 7053 DQASVQNALKDCQDLEDLIKAKEK---EVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQ 7109
Query: 139 LW----------DLLLELTLEKGDQLLRAL-KFQQYVQECADILEWI----GDKEAIATS 183
W +LL+ L++ A K Y+ E L G EA+
Sbjct: 7110 TWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQ 7169
Query: 184 VELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQN--- 240
V+ ++ Q +L +E + + N+ +E HP P+ ++ N
Sbjct: 7170 VD-------------NLQNLQDDLEKQERSLQKFGSITNQLLKECHP--PVTETLTNTLK 7214
Query: 241 EVNAAWERL-RGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEP-------VLTSEDY 292
EVN W L +A Q Q + + QR+K + ++++E T++D
Sbjct: 7215 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 7274
Query: 293 GKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSW 352
D VA+ L + L + D + L E+L DA ++ D +S
Sbjct: 7275 ADDEVAT--WIQDCNDLLKGLGTVKDSLFFLHELGEQL--KQQVDASAASAIQSDQLSLS 7330
Query: 353 EHIRALATS---RYEKLQATYW-YHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVL 408
+H+ AL + + LQA Y F+ + L W+ E + + P+ + +
Sbjct: 7331 QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQD-PSHSSDLSTI 7389
Query: 409 LDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDER 468
+R ++ K ++ + D + + +D+ ++M+ L+ +W+ + ER
Sbjct: 7390 QERMEELKGQMLKFSSMAPDLDRLNE--LGYRLPLNDKEIKRMQNLNRHWSLISSQTTER 7447
Query: 469 HRQYEQCLDFHLFYRDSEQVDSWMS---RQEAFLENEDLGNSLGSAEALLQKHEDFEEAF 525
+ + L H + E+ ++WM + E L E GN E + HE F+
Sbjct: 7448 FSKLQSFLLQHQTFL--EKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ-RAHELFQAEM 7504
Query: 526 TAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARR-DALREKAATRRRLLKESLLL 584
++++ + ++ +L+ D + ++ LL+ + + +A RR ++ +
Sbjct: 7505 FSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQ 7564
Query: 585 QKLYED-SDDLKNWINKKKKLADDE------DYKDIQNLKSRVQ-KQQVFEKELAVNKTQ 636
+ Y + ++ L+ W+ + L + + L VQ K++VF ++ +
Sbjct: 7565 WQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG---SY 7621
Query: 637 LENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQF---- 692
+ ++ Q ++ A + L+E+ W K +L E ++L F
Sbjct: 7622 ILTVEAGKQLLLSADSGAEAALQAELAEIQEKW-------KSASMRLEEQKKKLAFLLKD 7674
Query: 693 ----ENNAEDLQRWLEDVEWQVTSE--DYGKGLAEVQNRLRKHGLLESAVAARQD---QV 743
E D L + +++ D+ + L Q R ++ LE+AV + D Q+
Sbjct: 7675 WEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE---LENAVGSWTDDLTQL 7731
Query: 744 DILTD-LAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT 802
+L D L+AY I D + R E L ++E L L+ R++++ + L+ + +
Sbjct: 7732 SLLKDTLSAY---ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7788
Query: 803 EDEEA-WIQETEPSATST----------YLGKDLIASKKLLNRHRVILENI------ASH 845
E W+ + E + L KD + +++ L+ + ASH
Sbjct: 7789 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASH 7848
Query: 846 EPRIQEITERGNKMVEEGHFAAEDVASRVK----------SLNQNMESLRARAARRQNDL 895
E + EI + K+ + + +A+RVK L++NM SLR A +++L
Sbjct: 7849 ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 7908
Query: 896 EANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSM 955
+ + + E + + E++ + + ++L E L D +
Sbjct: 7909 AKPIVYDS--CNSEEIQRKLNEQQEL--QRDIEKHSTGVASVLNLCEVLLHDCD------ 7958
Query: 956 KALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWW 1015
A A QQA + R + + R E T + S +DW
Sbjct: 7959 -ACATDAECDSIQQA--TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 8015
Query: 1016 KVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLL------- 1068
K + + +A +E +R+ +TQ E I QYR L
Sbjct: 8016 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ-LELINKQYRRLARENRTDS 8074
Query: 1069 ---------------DRAEERRRRLLQRYNEFLLAYE-----AGDMLEWIQEKKAENTGV 1108
D ++R +L+R F+ E +L W+ E + T +
Sbjct: 8075 ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 8134
Query: 1109 ELDDVWELQKKFDE---FQKDLNTNEPRLRDINKVADDL------LFEGLLTPEGAQIRQ 1159
E ++Q K + FQ++++ N ++ I + L L ++ E ++R+
Sbjct: 8135 EHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 8194
Query: 1160 ELNSRWGSLQR---------LADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAAD 1210
+G ++R L D++ L S +E+ A ++ +L +
Sbjct: 8195 YCQEVFGRVERYHKKLIRLPLPDDEHDL--SDRELELEDSAALSDLHWHDRSADSLLSPQ 8252
Query: 1211 PGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHP-DATEDLQRQKMELNE 1269
P S+L A R E RD D + L H D + DL+ M
Sbjct: 8253 PSSNLSLSLAQPLRSERSGRDTPASVDSIP--------LEWDHDYDLSRDLE-SAMSRAL 8303
Query: 1270 AWEDLQGRTKDRKESLNEAQKFYL-----FLSKARDLQNWISSIGGMVSSQELAEDLTGI 1324
ED +G+ + + FYL L++ I +G + T
Sbjct: 8304 PSEDEEGQ---------DDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQT-- 8352
Query: 1325 EILLERHQEHRADMEAEAPTFQALEDFSAELIDS----GHHASPEIEKKLQAVKLERDDL 1380
E ++ +++ + L + IDS H E E V L +
Sbjct: 8353 ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 8412
Query: 1381 EKA-----WE--------KRKKILDQCLELQMFQGNCDQVESWMVARENSL----RSDDK 1423
+ A WE K ++ + Q F + + + +W+ E L R +
Sbjct: 8413 QTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELS 8472
Query: 1424 SSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWK 1483
+ + ++E +KK +L KA+ ++ I + + + ++ RL ++ RW
Sbjct: 8473 TDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWD 8532
Query: 1484 ALKAQLIDERTKLGDYANLKQFYRD--------LEELEEWISEMLPTACDESYKDATNIQ 1535
+ + L + R L D Q + + LE ++ +E++P +S DA +Q
Sbjct: 8533 RVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPI---DSNLDAEILQ 8589
Query: 1536 RKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLER 1595
+ + HE+ +V + ++ L+ + EA KE++ + LL+
Sbjct: 8590 DHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLKLLLKE 8648
Query: 1596 TNDKGKKLNEASRQQRFNTSIRDFEFWLSEAE 1627
+ + + E + ++S +D W S E
Sbjct: 8649 VS---RHIKELEKLLDVSSSQQDLSSWSSADE 8677
Score = 94.4 bits (233), Expect = 1e-18
Identities = 414/2210 (18%), Positives = 848/2210 (38%), Gaps = 319/2210 (14%)
Query: 235 IQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGK 294
+Q +++ W+ L+G A L RF V E + ++E L ++ +
Sbjct: 997 LQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTEL-DRETKLMPQEGSE 1055
Query: 295 DLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEH 354
++ +F S KG ++ELC K L + P +++ + +
Sbjct: 1056 KIIKEHRVFFSDKGPHHLCEKRLQLIEELCVK---LPVRDP-----VRDTPGTCHVTLKE 1107
Query: 355 IRALATSRYEKL-QATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQ 413
+RA S Y KL + + ++S F E S W++ + + G + H
Sbjct: 1108 LRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKG------IKGEAIDTANHG 1161
Query: 414 QHKHEIDSYDDRFQSADETGQDL---------VNANHEASDEVREKMEILDNNWTALLEL 464
+ K ++ + ET L V++ +EA + +++ L +++ AL+ L
Sbjct: 1162 EVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQ-GDELAKLSSSFKALVTL 1220
Query: 465 WDERHRQ---YEQCLDFHLFYRDS--EQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHE 519
E + + C+ + ++S E + QE + D N L A+ LL H+
Sbjct: 1221 LSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTEN-LFEAQQLLLHHQ 1279
Query: 520 DFEEAFTAQ----EEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRR 575
+ +A+ +++I + L H + +++ DGL R+ +
Sbjct: 1280 QKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTL 1339
Query: 576 RLLK-----ESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKEL 630
R + + +++ L++ + +++ + +++L S +++ + F K
Sbjct: 1340 RKWERFETNKETVVRYLFQTGSSHERFLS----------FSSLESLSSELEQTKEFSKRT 1389
Query: 631 AVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEEL--LEATKQKGTQLHE--A 686
Q EN+ K E+ G N + S+ E++ LE T ++ + E
Sbjct: 1390 ESIAVQAENLVKEASEIPLG----PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVK 1445
Query: 687 NQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDIL 746
+ F +N E L W+ + E ++ + + ++Q K + E + ++ + L
Sbjct: 1446 TKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQE--IESKLSSIVGL 1503
Query: 747 TDLAAYFEE-IGHPDSKDIRARQESLVCRFEALKE-----------PLATRKKKLLDLLH 794
+ A F + + +S I+A+ + E L+E L+ ++K +L
Sbjct: 1504 EEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRK 1563
Query: 795 LQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITE 854
+Q + ED+ A + SAT TY K+L H + + + S I +
Sbjct: 1564 IQQSVSEFEDKLAVPIKICSSATETY---------KVLQEHMDLCQALESLSSAITAFSA 1614
Query: 855 RGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE-ANVQFQQYLADLHEAET 913
K+V E A L Q E + RA RQ LE +Q+ +L T
Sbjct: 1615 SARKVVNRDSCVQEAAA-----LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLT 1669
Query: 914 WIREKE-----PIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQ 968
W+ E P +D + E L++ + ++ SF + L+ + +
Sbjct: 1670 WLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASK 1729
Query: 969 QAAPVEGVAGEQRVMALYDFQARSPREVTM--------KKGDVLTLLSSINKDWWKVEAA 1020
+ + EQ D + + ++ D L L S+ W K+ +
Sbjct: 1730 DDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSV---WIKLFLS 1786
Query: 1021 DHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSL-----LDRAEERR 1075
+ Q ++ + + R ++ + ++ ++++ L L RAE+
Sbjct: 1787 ELQ------TTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAED-- 1838
Query: 1076 RRLLQRYNE--FLLAYEAGDMLEWIQEKKAE-----NTGVELDDVWELQKKFDEFQKDLN 1128
LLQ E F L EA ++E Q + + L + ++ E +N
Sbjct: 1839 LHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMN 1898
Query: 1129 TNEPRL--RDINKVADD--------LLFEGLLTPEGAQIRQELNSRWGSLQRLADEQ--- 1175
NE L +D+N + + +G+L+ ++ + + S + AD+
Sbjct: 1899 KNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGE 1958
Query: 1176 ----RQLLGS----AHAVEVFHREADDTKEQIEKKCQALSAADPGSDLF--SVQALQRRH 1225
+ LLG+ A A+ V + D KE++ K + + L + QALQ+R
Sbjct: 1959 VERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRL 2018
Query: 1226 EGF---ERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDL-------Q 1275
F E +L ++ L + A+++++ ++ R+ L W+D Q
Sbjct: 2019 RVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQ 2078
Query: 1276 GRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHR 1335
G+ + + E Q +SK + + ++ ++ +D ++ +H+ +
Sbjct: 2079 GQCCGLIDLMREYQNLKSAVSKV------LENASSVIVTRTTIKDQEDLKWAFSKHETAK 2132
Query: 1336 ADMEAEAPTFQALEDFSAELIDSGHHASPEIEK----KLQAVKLERDDLEKAW----EKR 1387
M + + L++F+++ G H E++K VK + + W EK
Sbjct: 2133 NKMNYKQ---KDLDNFTSK----GKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKL 2185
Query: 1388 KKILDQC-LELQMFQ---GNCDQVESWMVARENSL--RSDDKSSLDS---LEALMKKRDD 1438
++ +D+ + L ++ D++E W N + +++ S+LD+ E L+K+ +
Sbjct: 2186 EENMDRLRVSLSIWDDVLSTRDEIEGW---SNNCVPQMAENISNLDNHLRAEELLKEFES 2242
Query: 1439 --LDKAITAQE--GKITDLEHFAESLIA--DEHYAKEEIATRLQRVLDRWKALKAQLIDE 1492
+KA+ +E K+ DL+ ++L D + + ++ +L+ + + K L D
Sbjct: 2243 EVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDF 2302
Query: 1493 RTKLGDYANLKQFYRDL----EELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEV 1548
+ +++F D+ ++EE + E+ K +IQ++ Q+ +
Sbjct: 2303 TAQ---STQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQS---NI 2356
Query: 1549 DGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASR 1608
E + NSL E + +K+H + + K + + S
Sbjct: 2357 SSTQENL-------NSLCRKYHSAELESLGRAMTGLIKKH--EAVSQLCSKTQASLQESL 2407
Query: 1609 QQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNT 1668
++ F+ S+++F+ W A+ A K+ + + L K L+ + + D L+
Sbjct: 2408 EKHFSESMQEFQEWFLGAKA--AAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDA 2465
Query: 1669 LAEDLLSSGTFNVDQIVKK-KDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEES 1727
+ ++ + QIV ++ + K +E A + LK+ AL +L E
Sbjct: 2466 VTQEGQTLYAHLSKQIVSSIQEQITKA---NEEFQAFLKQCLKDKQALQDCASELGSFED 2522
Query: 1728 -------WIEEKLIRVSSQDYGRDLQGV---QNLLKKHKRLEGELVAHEPAIQNVLDMAE 1777
WI E R ++++ G Q + +N + K + GEL+A ++ + +
Sbjct: 2523 QHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQ 2582
Query: 1778 KLKDKAAVGQEEIQLRLAQFVEHW-------EKLK--ELAKARGLKLEESLEYLQFMQNA 1828
L ++ +E +L H EKL+ ++A LEE+L+ + F A
Sbjct: 2583 LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKA 2642
Query: 1829 EEE-----EAWINEKNALAVRGDCGDTLAATQS-LLMKHEALENDFAVHETRVQNVCAQG 1882
++ E+ + K+ L R L+ Q LLMK E E ++ +G
Sbjct: 2643 IQDRLACAESTLGSKDTLEKR------LSQIQDILLMKGEG--------EVKLNMAIGKG 2688
Query: 1883 EDILNKVLQEESQNKE----ISSKIEALNEKTPSLAKAIAAWKLQLEDDYA-FQEFNWKA 1937
E L S NKE I +++E L E + + + LE + + ++ +
Sbjct: 2689 EQAL------RSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
Query: 1938 DVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLIS 1997
+ +E W+ + ++ L L K LD LQS E L +
Sbjct: 2743 NQLEQWMESVDQKIE-----HPLQPQPGLKEKFVLLD-HLQSILSEAEDHTRALHRLIAK 2796
Query: 1998 AQHNQSKAIEERY--AALLKRWEQLLEASAVHRQK------LLEKQLPLQKAEDLFVEFA 2049
++ K +E + A + Q + V ++K +++ L A F ++
Sbjct: 2797 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2856
Query: 2050 HKA-SALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQ 2108
H A L+ W + ++ + L++I++L E + L+R ++ E+ Q
Sbjct: 2857 HSAKEELHRWSDMSGDSSATQ---KKLSKIKELIDSREIGASRLSRVES---LAPEVKQN 2910
Query: 2109 IKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQEL----------QKEEARQVKNFEM 2158
A G ++ L WK D + + + L ++E + QV E
Sbjct: 2911 TTASG---CELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLE- 2966
Query: 2159 CQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218
Q EQ ++ W + +LL+ T E +E + Q+ + A+++ + D
Sbjct: 2967 -QALEQFSALLKTWAQQL-------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED 3018
Query: 2219 LGDNLEDALILDIKYSTI-----GLAQQWDQLYQLGLRMQHNLEQQIQAK 2263
L L + ST GL ++++ L + N EQ +Q +
Sbjct: 3019 LKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQR 3068
Score = 92.0 bits (227), Expect = 6e-18
Identities = 446/2447 (18%), Positives = 932/2447 (38%), Gaps = 333/2447 (13%)
Query: 29 QEVLTRYQSFKERVAERGQKLEDSYHL-QVFKRDADDLGKWI------MEKVNILTDKSY 81
Q++ RY++ +ER E K E L Q ++RD W+ +++ ++L ++
Sbjct: 3467 QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH 3526
Query: 82 EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWD 141
T ++ Q L+ L++ + TRE+ G E+ +E LR W
Sbjct: 3527 THETTLRDL----QELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRA--LESLRQDWQ 3580
Query: 142 LLLELTLEKGDQLLRAL-KFQQYVQECADILEWIGD-KEAIATSVELGEDWERTEVLHKK 199
E Q + K + Q+ + EW+ +E ++ + E+ +
Sbjct: 3581 AYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQ 3640
Query: 200 FEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKA 259
+ + E+ A V EV A E +E+H + + + ++ + ++ L L++ K
Sbjct: 3641 MKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRM-GCQATQLTSRYQALLLQVLEQIKF 3699
Query: 260 LSNAA-NLQRFKRDVTEAIQWI----KEKEPVLTSED------YGKDLVASEGLFHSHKG 308
L +L+ + ++ W K + V T D GK L E L K
Sbjct: 3700 LEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLL---KD 3756
Query: 309 LERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRAL-ATSRYEKLQ 367
+E+ +++ +E +A K + + + +++++ E ++ L +T R E +
Sbjct: 3757 MEKGHSLLKS-AREKGERAVKYL-----EEGEAERLRKEIHDHMEQLKELTSTVRKEHMT 3810
Query: 368 ATYWYH---RFSSDFDELSGWMNEKTAAINADELPT-DVAGGEVLLDRHQQHKHEIDSYD 423
H FS L+ W+ E ++ E P ++ + L +++ + + S++
Sbjct: 3811 LEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHE 3870
Query: 424 DRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYR 483
+S E G+ L+ + + +++K++ L +++ L + E E + H Y
Sbjct: 3871 PSVKSVREKGEALLELVQDVT--LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYN 3928
Query: 484 DS-EQVDSWMSRQEAFLENEDL--GNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTAT 540
++V+ W+ + L DL +SL + L H+ E E+++ +
Sbjct: 3929 SELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGD 3988
Query: 541 KLIGD--DHYDSENIKAIRDGLLARRDALREKAATRRRLLKE-SLLLQKLYEDSDDLKN- 596
LIG DH ++ + + L +D+ +T +R+ + LQK D L+
Sbjct: 3989 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQC 4048
Query: 597 --WINK---------KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQ-KTG 644
W++ + L+ E K +++ ++ +Q+Q +L + L N KT
Sbjct: 4049 QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRA-LQEQARTYLDLLCSMCDLSNASVKTT 4107
Query: 645 QEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLE 704
+ I+ + + + WEE+ + L +A+QQLQ +++R
Sbjct: 4108 AKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQ------NMKRRHS 4161
Query: 705 DVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILT--DLAAYFEEIGHPDSK 762
++E + +++V++ ++K +++V ++V+ LT + + +EI H + +
Sbjct: 4162 ELELNIAQ----NMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQ 4217
Query: 763 DI-RARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYL 821
+ RQ + +C +E R + D +++ + + E W A ST +
Sbjct: 4218 WLDLCRQSNNLC---LQREEDLQRTRDYHDCMNVVEVFLEKFTTE-WDNLARSDAESTAV 4273
Query: 822 GKDLIASKKL---LNRHRVILENIASHEPRI--------QEITERGNKMVEEGHFAAEDV 870
L A KKL L + +E++ + ++ +E+ + +E+ F ED+
Sbjct: 4274 --HLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL 4331
Query: 871 ASR-VKSLNQNMESLRARAARRQNDLEANVQFQQYLAD-LHEAETWIREKEPIVDNTNYG 928
R ++ N+E L +R Q +E + Q +A+ L ++ + ++D+
Sbjct: 4332 IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAIC 4391
Query: 929 ADEEAAGALLKK----HEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQR--- 981
++ EA LLK + + DL G + + + +A + Q + + G++R
Sbjct: 4392 SELEAKQMLLKSLIKDADRVMADL---GLNERQVIQKALSDAQSHVNCLSDLVGQRRKYL 4448
Query: 982 ----------VMALYD--FQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAV 1029
+MA++ Q + M + + L ++K ++A
Sbjct: 4449 NKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQN 4508
Query: 1030 YVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEER----------RRRLL 1079
V L ++ + +E + + +++++ Y S+L + R R+
Sbjct: 4509 EVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
Query: 1080 QRYNEFLLAYEAGDMLEWIQEKKAENTGVEL-------DDVWELQKKFDEFQKDL-NTNE 1131
+ +++ + D++ + E N EL ++ E +++ L T +
Sbjct: 4569 EDFDKACHWLKQADIVTF-PEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQ 4627
Query: 1132 PRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHRE 1191
L +N+V L E L L ++ + LA ++ + A +
Sbjct: 4628 TILPSLNEVDHSYLSEKL---------NALPRQFNVIVALAKDKFYKVQEAILARKEYAS 4678
Query: 1192 ADD--TKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERL 1249
+ T+ E + Q L + +DL +AL + +G L D+V LGE + L
Sbjct: 4679 LIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQ-DGCRAIL----DEVAGLGEAVDEL 4733
Query: 1250 S---ESHPDATEDLQRQKM-ELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWI 1305
+ E + Q KM L + L+ +T+ R L + Y K
Sbjct: 4734 NQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEK-------- 4785
Query: 1306 SSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPE 1365
Q+L L ++ + E E + + +L + L DSG
Sbjct: 4786 -------MCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSL---AGSLQDSG------ 4829
Query: 1366 IEKKLQAVKLERDDLEK-----AWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRS 1420
L+ V + +DL A+EK + ++Q +QG + S + S
Sbjct: 4830 --IVLKRVTIHLEDLAPHLDPLAYEKARH------QIQSWQGELKLLTSAIGETVTECES 4881
Query: 1421 DDKSSLDSLEALMKKRDDLDKAITAQEGKI---TDLEHFAESLIADEHYAKEEIATRLQR 1477
S+D + + D L + G + +L+ E + + + +E +Q
Sbjct: 4882 RMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEE-----VQS 4936
Query: 1478 VLDRWKALKAQLIDERTKLGDY--ANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQ 1535
L AL + ++ TK + A+L+ +L EL+ I E L T
Sbjct: 4937 SLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRT------------- 4983
Query: 1536 RKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECS----ACDGNEEAMKEQLEQLKEHWDH 1591
Q E+ + ++ + V N +E + GN ++ E LK H +
Sbjct: 4984 -----RQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEF 5038
Query: 1592 LLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQL 1651
S + +F++++ + ++ + L+ + +L + Q
Sbjct: 5039 F--------------STEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQR 5084
Query: 1652 LEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRF--LNVQELAAAH--HE 1707
+ R+ A+ D L+ D + +++++ ++ K+ ++ + +++H E
Sbjct: 5085 MSRDSGAQVDLLQRCTAQWHDYQKAR----EEVIELMNDTEKKLSEFSLLKTSSSHEAEE 5140
Query: 1708 KLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDL------QGVQNLLKKHKRLEGE 1761
KL E AL ++ +EEK ++ + G D + + + ++ RL
Sbjct: 5141 KLSEHKALVSVVNSFHEKIVALEEKASQL--EKTGNDASKATLSRSMTTVWQRWTRLRAV 5198
Query: 1762 LVAHEPAIQNVLD--------------MAEKLKDK--AAVGQEEIQLRLAQFVEHWE--- 1802
E +++ +D M ++L+DK + ++ + L +E+ +
Sbjct: 5199 AQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFV 5258
Query: 1803 -KLKELAKARGLKLEESLEYLQ--FMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLM 1859
+L++ A G+ +++L LQ EE + E A+ R T L+
Sbjct: 5259 LELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLV 5318
Query: 1860 KHEALENDFA----------VHETR------VQNVCAQGEDILNKVLQEESQNKEISSKI 1903
K E + + V ET+ + AQ E++ + + + + I
Sbjct: 5319 KQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMA 5378
Query: 1904 EALNEK----------TPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKT 1953
E EK SL A A L++ D Q + +V ++ +E S +
Sbjct: 5379 EEQKEKYLGLYTILPSELSLQLAEVALDLKIRD----QIQDKIKEVEQSKATSQELSRQI 5434
Query: 1954 NGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAAL 2013
DL LT L + ++ Q+ E+ KL+ K +E+
Sbjct: 5435 QKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLG 5494
Query: 2014 LKRWEQLLEASAVHRQKLLEKQLPLQK---AEDLFVEFAHKASALNNWCEKMEENLSEPV 2070
+++ + + +H+Q + + + L K A E+ + W EK + +
Sbjct: 5495 KPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTI 5554
Query: 2071 HCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERT 2130
S +++R+ H+ L ++ + + E Q + + V + V L R
Sbjct: 5555 AWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTS--VYCTEKMSQQVAELGRE 5612
Query: 2131 WKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETG 2190
+ L +I+ R Q LQ + A+ +K FE E ++ LQ LE L E G
Sbjct: 5613 TEELRQMIKIRLQNLQ-DAAKDMKKFE--AELKK-----LQAALEQAQATLTS---PEVG 5661
Query: 2191 --TLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQL 2248
+L+ QL + E++++K ++ + L I + +++ L +L +
Sbjct: 5662 RLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALR---IPEDVVASLPLCHAALRLQEE 5718
Query: 2249 GLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKE 2295
R+QH QQ V E ++ KH + + G H+E
Sbjct: 5719 ASRLQHTAIQQCNIMQAAVVQYE---QYEQEMKHLQQLIEG--AHRE 5760
Score = 87.4 bits (215), Expect = 2e-16
Identities = 190/1051 (18%), Positives = 409/1051 (38%), Gaps = 129/1051 (12%)
Query: 2 EQFPKETVVES---SGPKVLETAE-----EIQERRQEVLTRYQSFKERVAERGQKLEDSY 53
E F ++ ++ S G ++LE + E + + ++Q R +R ++
Sbjct: 7503 EMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQI 7562
Query: 54 HL-QVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSE-- 110
Q ++ A+ L KW++E + P +Q + ++L EVQ K ++
Sbjct: 7563 RQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQ----QARTLFDEVQFKEKVFLRQQ 7618
Query: 111 ------LEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYV 164
+E ++ + A +A + E++ W E+ +L LK
Sbjct: 7619 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK----- 7673
Query: 165 QECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANEC 224
+W ++ IA S+E +++ L + D EL A++ R E+
Sbjct: 7674 -------DWEKCEKGIADSLEKLRTFKKK--LSQSLPDHHEELHAEQMRCKELENAVGSW 7724
Query: 225 AEE---------------NHPDLPLIQSKQNEVNAAWERL-RGLALQRQKALSNAANLQR 268
++ + D+ ++ + + WE L L+L+RQ+
Sbjct: 7725 TDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV 7784
Query: 269 FKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAE 328
F E +W+ + E ++ D++ E + K + +A+ + +L E
Sbjct: 7785 FSEKNKELCEWLTQMESKVSQNG---DILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGE 7841
Query: 329 KLT-LSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQAT-YWYHRFSSDFDELSGWM 386
+L SH S A +I+ + W+H+ L +R +KL+ T + + L W+
Sbjct: 7842 RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL 7901
Query: 387 NEKTAAINADELPTDVAGGEVL---LDRHQQHKHEIDSYDDRFQSADETGQDLVN----- 438
+ + A + D E + L+ Q+ + +I+ + S + L++
Sbjct: 7902 AHIESEL-AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDAC 7960
Query: 439 ANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLD-FHLFYRDSEQVDSWMSRQE- 496
A D +++ LD W + + ER + E+ + F D + + W+ E
Sbjct: 7961 ATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 8020
Query: 497 --AFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSE-NI 553
AF + + ++ E L+K E F+ ++ ++K +L ++ DS ++
Sbjct: 8021 TAAFPSSSGVIYTVAKEE--LKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 8078
Query: 554 KAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDS-DDLKNWINKKKKLADDEDYKD 612
K + R D L+++ + R LK + ++ +E + D + W+ + + ++
Sbjct: 8079 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 8138
Query: 613 IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGH-YASDNVTTRLSEVASLWEE 671
++++++++ + F++E+++N ++E I G+++IE + + L E+ +E
Sbjct: 8139 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 8198
Query: 672 LLEATKQKGTQL---------HE-ANQQLQFENNAEDLQRWLEDVEWQVTSED------- 714
+ ++ +L H+ ++++L+ E++A L D+ W S D
Sbjct: 8199 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAA-----LSDLHWHDRSADSLLSPQP 8253
Query: 715 -------YGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDL------AAYFEEIGHPDS 761
+ L ++ ++S D+ DL A E+ D
Sbjct: 8254 SSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD 8313
Query: 762 KDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYL 821
KD R + + E + K LD Q+ + TE+ T P ++Y
Sbjct: 8314 KDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQI--QQTENIIRSKTPTGPELDTSYK 8371
Query: 822 GKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNM 881
G KLL ++++ E +++E E G ++ +
Sbjct: 8372 G-----YMKLLGECSSSIDSVKRLEHKLKEEEES-----LPGFVNLHSTETQTAGVIDRW 8421
Query: 882 ESLRARAARRQNDLEANVQ-FQQYLADLHEAETWIREKEPIVD---NTNYGADEEAAGAL 937
E L+A+A ++ ++ N+Q +QQ+ +DL+ W+ + E ++ D +
Sbjct: 8422 ELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQ 8481
Query: 938 LKKHEAFLLDLNSFGDSMKALRNQANACQQQ 968
+KK L +L D KA+ N C +
Sbjct: 8482 IKK----LKELQKAVDHRKAIILSINLCSPE 8508
Score = 82.0 bits (201), Expect = 6e-15
Identities = 357/1985 (17%), Positives = 743/1985 (37%), Gaps = 279/1985 (14%)
Query: 337 DAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYW-YHRFSSDFDELSGWMNEKTAAINA 395
+A + + + + W ++ S L+ + R+ + L W+ + +N
Sbjct: 579 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
Query: 396 DELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHE-ASDEVREKMEIL 454
E + + + + + + ++ G L+ E S ++++++ +L
Sbjct: 639 SE------------NAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLL 686
Query: 455 DNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEAL 514
+ W L + +++ Q ++ Y D S + + +E L S + + L
Sbjct: 687 NGRWRELF-MEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLL 745
Query: 515 LQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATR 574
+Q ED E+ + + + KTA LI + E + + + K
Sbjct: 746 IQDLEDIEQRVPVMDAQYKIITKTA-HLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
Query: 575 RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNK 634
L + LL L E + ++ + K+ + I L+ Q +F+++
Sbjct: 805 PLLYESQQLLIPLEELEKQMTSFYDSLGKINEI-----ITVLEREAQSSALFKQKHQELL 859
Query: 635 TQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFEN 694
EN +KT +IE G + T LS V L+ Q Q A+ + F++
Sbjct: 860 ACQENCKKT-LTLIEKGSQSVQKFVT-LSNV-------LKHFDQTRLQRQIADIHVAFQS 910
Query: 695 NAEDLQRWLEDVEWQVT-SEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYF 753
+ W + VE + + + AE++ LR + + + + D ++L +F
Sbjct: 911 MVKKTGDWKKHVETNSRLMKKFEESRAELEKVLR---IAQEGLEEKGDPEELLRRHTEFF 967
Query: 754 EEIGH----------PDSKDIRARQESLVCRFEALKEPLATRKKKLLDL--------LHL 795
++ + DI QE + L+E + K+ DL LHL
Sbjct: 968 SQLDQRVLNAFLKACDELTDILPEQEQ-----QGLQEAVRKLHKQWKDLQGEAPYHLLHL 1022
Query: 796 QLICRDTEDEE--AWIQE--TEPSATSTYLGKDLIASKKLLNRHRVILENIASH---EPR 848
++ D E A ++E TE + + ++ S+K++ HRV + H E R
Sbjct: 1023 KI---DVEKNRFLASVEECRTELDRETKLMPQE--GSEKIIKEHRVFFSDKGPHHLCEKR 1077
Query: 849 IQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDL-EANVQFQQYLAD 907
+Q I E K+ + V + + ++ LRA L E +++ Y +
Sbjct: 1078 LQLIEELCVKLP-----VRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSR 1132
Query: 908 LHEAETWIREKEP--------IVDNTNYG----ADEEAAGALLKKHEAF---------LL 946
E +WI E +D N+G A EE + K+ E L
Sbjct: 1133 FSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLT 1192
Query: 947 DLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTL 1006
+++S ++ K A +A V ++ +++++ + + V ++++
Sbjct: 1193 EVSSENEAQKQGDELAKLSSSFKAL-VTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISG 1251
Query: 1007 LSSINKDWWKVEAAD-----------HQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQ 1055
+ + K+ + HQ + ++ D + Q ++ E G +
Sbjct: 1252 SKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKK--RDVQQQIAQAQQGEGGLPDR 1309
Query: 1056 RQEQIENQYRSL--LDRAEERRRRLLQ----RYNEF--------LLAYEAGDMLE-WIQE 1100
E++ +L L+R+ ER+ R +Q ++ F ++ G E ++
Sbjct: 1310 GHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSF 1369
Query: 1101 KKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE 1160
E+ EL+ E K R I A++L+ E P G Q +Q
Sbjct: 1370 SSLESLSSELEQTKEFSK--------------RTESIAVQAENLVKEASEIPLGPQNKQL 1415
Query: 1161 LNSRWGSLQ----RLADEQRQLLGSAHAVEV----FHREADDTKEQIEKKCQALSAADPG 1212
L + S++ +L D + + + V+ F + I +K + L+A +
Sbjct: 1416 LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETS 1475
Query: 1213 SDLFSVQALQRRHE------------GFERDLVPLGDKVTILGETAERLSESHPDATEDL 1260
S +Q Q + G E + VT GE+A ++ +
Sbjct: 1476 SSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTT-GESARIKAK-----LTQI 1529
Query: 1261 QRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQ-ELAE 1319
+R EL E + L+G L++ QKF R +Q +S ++ ++
Sbjct: 1530 RRYGEELREHAQCLEGTILGH---LSQQQKFE---ENLRKIQQSVSEFEDKLAVPIKICS 1583
Query: 1320 DLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDD 1379
T +L+ H + +E+ + A + ++++ ++ A++ + +D
Sbjct: 1584 SATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRD-----SCVQEAAALQQQYED 1638
Query: 1380 LEKAWEKRKKILDQCL-ELQMFQGNCDQVESWMV---ARENSLRSDDKSSLDSLEALMKK 1435
+ + ++R+ L+ L Q + +W+ A+ +S D + +E ++
Sbjct: 1639 ILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQL 1698
Query: 1436 RDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIAT---RLQRVLDRWKALKAQLIDE 1492
L + +Q + L ESL + +K+++ L+++ +RW+ L Q+I++
Sbjct: 1699 IQALQNEVVSQASFYSKLLQLKESLFSVA--SKDDVKMMKLHLEQLDERWRDLP-QIINK 1755
Query: 1493 RTKL--GDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDG 1550
R A +QF L WI L S + Q +H+ A EV+
Sbjct: 1756 RINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1815
Query: 1551 RSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLE-RTNDKGKKLNEASRQ 1609
+ ++ +L L + + E+ HLL+ + D + EAS+
Sbjct: 1816 KKGELQ---SLQGHLAKLGSLGRAEDL-------------HLLQGKAEDCFQLFEEASQV 1859
Query: 1610 -QRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQ--LLEREM---LAREDAL 1663
+R ++ +L +L + Q R A N + K++ L+E+++ L AL
Sbjct: 1860 VERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKAL 1919
Query: 1664 KDLNTLAEDLLSSGTFNV-----DQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF-- 1716
+ + +LS +++ +Q + ++ V+ + K EA AL
Sbjct: 1920 ESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVL 1979
Query: 1717 -QFFQDLDDEE----SWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQN 1771
+ FQD +E IEE+ + ++ R Q +Q L+ +LE EL +HE +
Sbjct: 1980 KKAFQDQKEELLKSIEDIEERTDKERLKEPTR--QALQQRLRVFNQLEDELNSHEHELCW 2037
Query: 1772 VLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEE 1831
+ D A+++ K E+ + + W+ K L + ++ ++ QN +
Sbjct: 2038 LKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSA 2097
Query: 1832 EAWI--NEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKV 1889
+ + N + + R D + KHE +N + + N ++G+ +L+++
Sbjct: 2098 VSKVLENASSVIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL 2156
Query: 1890 LQEESQN-----KEISSKI-------EALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKA 1937
+ S + ++ S + E L E L +++ W DD
Sbjct: 2157 KKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIW-----DDVLSTR----- 2206
Query: 1938 DVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERL-PEITDLKDKLI 1996
D +E W + + N + D L K+ + ++ + E L ++ DLK+ +
Sbjct: 2207 DEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKE--L 2264
Query: 1997 SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALN 2056
+ ++ A L+++ E E + V + L + + E + +
Sbjct: 2265 TKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFI-------NDIT 2317
Query: 2057 NWCEKMEE---NLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALG 2113
W K+EE N ++ C +L +++ +QK+ + ++++ Q + L
Sbjct: 2318 TWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCR--------- 2368
Query: 2114 VPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173
Y +E L R L E Q K +A ++ E + F ++ F +W
Sbjct: 2369 ----KYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWF 2422
Query: 2174 LETRA 2178
L +A
Sbjct: 2423 LGAKA 2427
Score = 73.9 bits (180), Expect = 2e-12
Identities = 258/1302 (19%), Positives = 485/1302 (37%), Gaps = 211/1302 (16%)
Query: 1108 VELDDVW-ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWG 1166
+E D W + +F EF ++TNE +L+ I A D G + +IR + R
Sbjct: 1120 MEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGE 1179
Query: 1167 SL-------------------QRLADEQRQLLGSAHAVEVFHREAD----------DTKE 1197
+L Q+ DE +L S A+ E + KE
Sbjct: 1180 TLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKE 1239
Query: 1198 QIEKKCQALSAAD-----------PGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETA 1246
++ + L + +LF Q L H+ + + V A
Sbjct: 1240 IVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQA 1299
Query: 1247 ERLSESHPDATEDLQRQKMELNEAWEDLQG--RTKDRKESLNEA--QKFYLFLSKARDLQ 1302
++ PD R EL + L G R+++R+E + +K+ F + +
Sbjct: 1300 QQGEGGLPD------RGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVV 1353
Query: 1303 NWISSIGGMVSSQELAEDLTGIEIL---LERHQEHRADMEAEAPTFQALEDFSAELIDSG 1359
++ G SS E + +E L LE+ +E E+ A + L ++E I G
Sbjct: 1354 RYLFQTG---SSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
Query: 1360 HHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQC-LELQMFQGNCDQVESWMVARENSL 1418
++++ +++K + LE E+ K ++ + F N + + W+ +E L
Sbjct: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
Query: 1419 RSDDKSS--LD-SLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRL 1475
+ + SS +D + + +++ +++ G + + FA+ + E + T++
Sbjct: 1470 NALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQI 1529
Query: 1476 QRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEM-----LPTACDESYKD 1530
+R + + AQ + E T LG + ++F +L ++++ +SE +P S
Sbjct: 1530 RRYGEELRE-HAQCL-EGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSS--- 1584
Query: 1531 ATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWD 1590
AT + +H ++ S + ++ +C A+++Q E
Sbjct: 1585 ATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYED------ 1638
Query: 1591 HLLERTNDKGKKL-NEASRQQRFNTSIRDFEFWL--SEAETLLAMKDQARDLASAGNLLK 1647
+L R ++ L N + QR + F WL EA+ D + D L+
Sbjct: 1639 -ILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQ 1697
Query: 1648 KHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHE 1707
Q L+ E++++ L L E L S V KD+V L++++L +
Sbjct: 1698 LIQALQNEVVSQASFYSKLLQLKESLFS---------VASKDDVKMMKLHLEQLDERWRD 1748
Query: 1708 KLKEAYALFQFFQDLDDEESWIEEKLIRVS--SQDYGRDLQGVQNLLKKHKRLEGELVAH 1765
+ F Q + E +E L+ S + + +LQ + ++ H
Sbjct: 1749 LPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEI---------SIMDH 1799
Query: 1766 EPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFM 1825
+ A+ D A +++ K L H KL L +A L L + F
Sbjct: 1800 QVALTRHKDHAAEVESKKG--------ELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCF- 1850
Query: 1826 QNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGE-- 1883
EE + + E+ LA L+ L H +L V+ + +
Sbjct: 1851 -QLFEEASQVVERRQLA--------LSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNE 1901
Query: 1884 -DILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEA 1942
D++ K L + QN +AL SL ++ + L+ + Q + +A +
Sbjct: 1902 SDLIEKDLNDALQN------AKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRA-TADQ 1954
Query: 1943 WIADKETSLKTNGNGADLGDFLTLLAK--QDTLDASLQSFQ------------------- 1981
+ E G D L +L K QD + L+S +
Sbjct: 1955 LCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQAL 2014
Query: 1982 QERLPEITDLKDKLISAQH------NQSKAIEER---YAALLKRWEQLLEASAVHRQKLL 2032
Q+RL L+D+L S +H +++K I ++ +A + R LE + ++L+
Sbjct: 2015 QQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLI 2074
Query: 2033 -EKQLPLQKAEDLFVEFAHKASALNNWCE------------KMEENL--SEPVHCVSLNE 2077
E Q DL E+ + SA++ E K +E+L + H + N+
Sbjct: 2075 HENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNK 2134
Query: 2078 IRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTV-EVLERTWKHLSD 2136
+ QKD ++F + ++ K + D + + S+ WL V E LE L
Sbjct: 2135 MNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRV 2194
Query: 2137 IIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQL 2196
+ + L + + + + +N S LD L E E +
Sbjct: 2195 SLSIWDDVLSTRDEIEGWSNNCVPQMAENISN------------LDNHLRAEELLKEFES 2242
Query: 2197 EANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNL 2256
E K K ++ + ++ + +L NLE D+++ L Q +++H
Sbjct: 2243 EV-KNKALRLEELHSKVNDLKELTKNLETP--PDLQFIEADLMQ----------KLEH-- 2287
Query: 2257 EQQIQAKDIKGVSEETLKEF---STIYKHFDENLTGRLTHKE 2295
AK+I V++ TLK+F ST + F ++T T E
Sbjct: 2288 -----AKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVE 2324
Score = 68.6 bits (166), Expect = 7e-11
Identities = 248/1276 (19%), Positives = 495/1276 (38%), Gaps = 204/1276 (15%)
Query: 1093 DMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTP 1152
+M WI++ + + T ++ + LQ K+ F+ E + + I + L +G L+
Sbjct: 322 EMKVWIEQFERDLTRAQMVES-NLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSL 380
Query: 1153 EGAQIRQELNSRWGSL-QRLADEQRQL-------LGSAHA----VEVFHREADDTKEQIE 1200
+ A ++Q W + RL D QL LG+ A EV RE ++ E
Sbjct: 381 DQALVKQS----WDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHE 436
Query: 1201 KKCQALSAA-DPGSDLFSVQALQRR--HEGFE-RDLVPLGDKVTILGETAERLSESHPDA 1256
+ + + DL +R HE + R + + L + AER +
Sbjct: 437 ETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFH--FVSS 494
Query: 1257 TEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQE 1316
T +L KME E K R SL L L++++ L++WI G S ++
Sbjct: 495 TSELHLMKMEFLEL--------KYRLLSL-------LVLAESK-LKSWIIKYGRRESVEQ 538
Query: 1317 LAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELI--DSGHHASPEIEKKLQAVK 1374
L ++ E+ E T+Q L+ + + D + + K +
Sbjct: 539 LLQNYVSFI-------ENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETT 591
Query: 1375 LERDDLEKAWEKRKKILDQCLELQMFQGNC-DQVESWMVARENSLRSDDKSSLDSLEAL- 1432
+ +L + +L++ + GN +++W+ E L + + D L
Sbjct: 592 AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 651
Query: 1433 --MKKRDDLDKA-----ITAQEGKITDLEH--------FAESLIADEHYAKEEIATRLQR 1477
+++ ++ A T E DL+ + E + + YA+ + R+++
Sbjct: 652 HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 711
Query: 1478 -VLDRWKALKAQLIDERTKLGD-----YANLKQFYRDLEELEEWISEMLPTACDESYKDA 1531
D L A + KL + + N+K +DLE++E+ + M D YK
Sbjct: 712 EYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVM-----DAQYKII 766
Query: 1532 TNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDH 1591
T AH + S Q G +KEQL ++KE +
Sbjct: 767 TKT----------AHLITKESPQEEG-----------KEMFATMSKLKEQLTKVKECYSP 805
Query: 1592 LLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQL 1651
LL + L E +Q TS D ++E T+L R+ S+ +KHQ
Sbjct: 806 LLYESQQLLIPLEELEKQM---TSFYDSLGKINEIITVLE-----REAQSSALFKQKHQ- 856
Query: 1652 LEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRF------LNVQELAAAH 1705
E+LA ++ K TL E G+ +V + V NV K F + ++ A
Sbjct: 857 ---ELLACQENCKKTLTLIE----KGSQSVQKFVTLS-NVLKHFDQTRLQRQIADIHVAF 908
Query: 1706 HEKLKEAYALFQFFQDLDD-----EESWIE-EKLIRVSSQDYGRDLQG-VQNLLKKHKRL 1758
+K+ + + EES E EK++R++ + G + +G + LL++H
Sbjct: 909 QSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQE--GLEEKGDPEELLRRHTEF 966
Query: 1759 EGELVAHEPAIQNVLDMAEKLKDKAAVGQEE-IQLRLAQFVEHWEKLKELAKARGLKLEE 1817
+L + + L ++L D +++ +Q + + + W+ L+ A L L+
Sbjct: 967 FSQL--DQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKI 1024
Query: 1818 SLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQN 1877
+E +F+ + EE ++ + L + ++ ++ +H +D H +
Sbjct: 1025 DVEKNRFLASVEECRTELDRETKLMPQ-------EGSEKIIKEHRVFFSDKGPH-----H 1072
Query: 1878 VCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAI-AAWKLQLEDDYAFQEFNWK 1936
+C + ++ ++ + + + L AI + ++ +ED ++++ +
Sbjct: 1073 LCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSR 1132
Query: 1937 ADVVEAWIADKETSLK-------TNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEIT 1989
+WI+ ET LK N ++ + + T S+ + RL +T
Sbjct: 1133 FSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLT 1192
Query: 1990 DL-KDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEF 2048
++ + Q ++ + + AL+ ++ + + + K++ E+L
Sbjct: 1193 EVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELI--- 1249
Query: 2049 AHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQ 2108
+ ++++E + + +L E +QL H+ ++ + D + + QQ
Sbjct: 1250 --------SGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQ 1301
Query: 2109 IKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNAST 2168
+ G+P + L + L ++ E+ +++E R + FE N T
Sbjct: 1302 GEG-GLPDRGHEEL---------RKLESTLDGLERSRERQERRIQVTLRKWERFETNKET 1351
Query: 2169 FLQWILET---RAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLED 2225
++++ +T FL S L+ +L S+LE K K +++ Q +V
Sbjct: 1352 VVRYLFQTGSSHERFLSFSSLE---SLSSELEQTKEFSKRTESIAVQAENLVK------- 1401
Query: 2226 ALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEE---TLKEFSTIYKH 2282
+ S I L Q QL Q + ++++Q+ K ++ EE T++ T + H
Sbjct: 1402 ------EASEIPLGPQNKQLLQ---QQAKSIKEQV--KKLEDTLEEDIKTMEMVKTKWDH 1450
Query: 2283 FDEN---LTGRLTHKE 2295
F N L+ +T KE
Sbjct: 1451 FGSNFETLSVWITEKE 1466
Score = 53.5 bits (127), Expect = 2e-06
Identities = 50/211 (23%), Positives = 94/211 (44%), Gaps = 15/211 (7%)
Query: 63 DDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELE-KTREER--- 118
DD I + NI+ K+ P + Y+ + L E + + LE K +EE
Sbjct: 8343 DDSRFQIQQTENIIRSKTPTGP-ELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 8401
Query: 119 --FTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRAL-KFQQYVQECADILEWIG 175
F HS +T I+ W+LL L K ++ + L K+QQ+ + I W+G
Sbjct: 8402 PGFVNLHSTETQTAGVIDR----WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLG 8457
Query: 176 DKEAIATS---VELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDL 232
D E +EL D + E+ KK ++ Q + ++ ++ +N + E + + +
Sbjct: 8458 DTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKES 8517
Query: 233 PLIQSKQNEVNAAWERLRGLALQRQKALSNA 263
+Q + +++N W+R+ L + + L +A
Sbjct: 8518 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDA 8548
Score = 39.3 bits (90), Expect = 0.047
Identities = 64/329 (19%), Positives = 123/329 (37%), Gaps = 48/329 (14%)
Query: 408 LLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDE 467
L D++Q KH Y+ + + + Q L + D+ ++ +W + +
Sbjct: 344 LQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLDQA-----LVKQSWDRVTSRLFD 398
Query: 468 RHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTA 527
H Q ++ L L + +W+ R E L E + Q HE+
Sbjct: 399 WHIQLDKSLPAPL-----GTIGAWLYRAEVALREEI---------TVQQVHEETANTIQR 444
Query: 528 --QEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKA--------ATRRRL 577
++ K + + A K + Y + ++ +G+ D L + A + L
Sbjct: 445 KLEQHKDLLQNTDAHKRAFHEIYRTRSV----NGIPVPPDQLEDMAERFHFVSSTSELHL 500
Query: 578 LKESLL------LQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELA 631
+K L L L LK+WI K + E +QN S ++ + FE+
Sbjct: 501 MKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQL--LQNYVSFIENSKFFEQY-- 556
Query: 632 VNKTQLENIQKTGQEMI--EGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQ 689
+ + +++T + + +G ++NV ++E + W L + + L E
Sbjct: 557 --EVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISN 614
Query: 690 L-QFENNAEDLQRWLEDVEWQVTSEDYGK 717
++ N LQ WLED E + + K
Sbjct: 615 WDRYGNTVASLQAWLEDAEKMLNQSENAK 643
>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform 4
[Homo sapiens]
Length = 3321
Score = 147 bits (370), Expect = 2e-34
Identities = 430/2236 (19%), Positives = 866/2236 (38%), Gaps = 316/2236 (14%)
Query: 133 IEELRHLWDLLLELTLEKGDQ-------LLRALKFQQYVQECADILEWIGDKEAIATSVE 185
++EL L D+ EL + G + L ++++ +Q+ AD+LE +K A +
Sbjct: 1081 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 1140
Query: 186 LGEDWERTEVLHKKFEDFQ---VELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEV 242
+ E ++L K E FQ ++ E ++ +A + + H +L +
Sbjct: 1141 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTEL------MAQA 1194
Query: 243 NAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGL 302
+A +R ++ + L ++L +++++ ++ ++ P + + +D +
Sbjct: 1195 SAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRIT 1254
Query: 303 FHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSD--APQIQEMKEDLVSSW----EHIR 356
+ H L+ +L K+ ++ ++L +S Q+ ++ E +S+ + +
Sbjct: 1255 LYQH--LKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELH 1312
Query: 357 ALAT-----SRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411
L T +RY+ A H S D L W + E+ D L+
Sbjct: 1313 RLETILKHWTRYQSESADL-IHWLQSAKDRLEFWTQQSVTVPQELEMVRDH------LNA 1365
Query: 412 HQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQ 471
+ E+D+ S TG L+ + +R ++ +D+ WT LL +
Sbjct: 1366 FLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEK 1425
Query: 472 YEQCLDFHLFYRDS-EQVDSWMSRQEAFLENED--LGNSLG--SAEALLQKHEDFEEAFT 526
Q L R + +V SW+S E ++ ++ + NS+G + LQK++ F+
Sbjct: 1426 LHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDIN 1485
Query: 527 AQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESL-LLQ 585
++ +TVD ++ D E+ ++ + + A+ + + L+ E + LL+
Sbjct: 1486 CKQ---LTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLE 1542
Query: 586 KLYEDSDD-------LKNWI-NKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQL 637
L E + LK W ++K+L D ++++ ++ Q E + + ++
Sbjct: 1543 GLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEV 1602
Query: 638 ENIQKTGQEMIEG-GHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNA 696
E I++ G +I+ S V + L E+ W L Q L
Sbjct: 1603 EKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSV---------- 1652
Query: 697 EDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFE-- 754
L +W +V + L E + L + LL ++ A Q QVD L +L E
Sbjct: 1653 --LDQWSSH---KVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ 1707
Query: 755 ----------------EIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLI 798
E P ++ + + + R+ L E +A + + LL L
Sbjct: 1708 ERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQR 1767
Query: 799 CRD--------TEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQ 850
+D + +E E +AT+ + D +A+ + +L+ + + + +
Sbjct: 1768 YKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVAT--WIQDCNDLLKGLGTVKDSLF 1825
Query: 851 EITERGNKMVEE-GHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANV-QFQQYLADL 908
+ E G ++ ++ AA + S SL+Q++ +L ++Q L+A V ++ + L
Sbjct: 1826 FLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSL 1885
Query: 909 HEAETWIREKEPIV--DNTNYGAD--------EEAAGALLK-KHEAFLLD-LNSFG---- 952
E WI E E I+ + ++ +D EE G +LK A LD LN G
Sbjct: 1886 EALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP 1945
Query: 953 ---DSMKALRNQANACQQQQAAPVEGVAGEQRVMALY-----------DFQARSPREVTM 998
+K ++N + E + Q + + +F ++ +++ +
Sbjct: 1946 LNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV 2005
Query: 999 K-KGDVLTLLSSIN-KDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQR 1056
+ G+ LL + ++ E Q I+ ++ + D +L Q + ++ +
Sbjct: 2006 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII-----DGQRLLEQGQVDDRDEFNLK 2060
Query: 1057 QEQIENQYRSLLDRAEERRR------RLLQRYNEFLLAYEAGDMLEWIQEKK-------- 1102
+ NQ++ ++ RA++RR R QRY E A + +W+ E
Sbjct: 2061 LTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM-----AEKLRKWLVEVSYLPMSGLG 2115
Query: 1103 -----AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQI 1157
+ D+V +K F Q + + AD E L E A+I
Sbjct: 2116 SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGA-EAALQAELAEI 2174
Query: 1158 RQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFS 1217
+++ S + RL +++++L E + D+ E++ + LS + P
Sbjct: 2175 QEKWKS---ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHH-EE 2230
Query: 1218 VQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKME-LNEAWEDLQG 1276
+ A Q R + E + D +T L + LS + +++E L WE+L
Sbjct: 2231 LHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH 2290
Query: 1277 RTKDRKESLNE-AQKFYLFLSKARDLQNWISSIGGMVSSQE--LAEDLTGIEILLERHQE 1333
+ R++ + E ++ +F K ++L W++ + VS L E++ IE L + +QE
Sbjct: 2291 QLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEM--IEKLKKDYQE 2348
Query: 1334 HRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKR-KKILD 1392
A + Q + + A+ S + EIE KL V L R KK+ +
Sbjct: 2349 EIAIAQENKIQLQQMGERLAKA--SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKE 2406
Query: 1393 QCLELQMFQGNCDQVESWMVARENSLRSD---DKSSLDSLEALMKKRDDLDKAITAQEGK 1449
+ +Q N + +W+ E+ L D + + ++ + ++ +L + I
Sbjct: 2407 TLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 2466
Query: 1450 ITDLEHFAESLIAD-EHYAKEEIATRLQ---RVLD-RWKALKAQLIDERTKLGDYANL-K 1503
+ + + E L+ D + A + +Q R LD RW+ + A ++ R K+ + L +
Sbjct: 2467 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 2526
Query: 1504 QFYRDLEELEEWISEMLPTACDES-----YKDATNIQRKYLKHQTFAHEVDGRSEQVHGV 1558
+F D E+W+ TA S Y A +K+ Q HE + E ++
Sbjct: 2527 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 2586
Query: 1559 I-NLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNE-ASRQQRFNTSI 1616
L SAC ++K+ + + + WD+L +R ++L +++ F T+
Sbjct: 2587 YRRLARENRTDSAC-----SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 2641
Query: 1617 RDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSS 1676
WL+E + L + + +K+ + ++E+ + + E +++
Sbjct: 2642 DSILVWLTEMDLQLTNIEHFSE-CDVQAKIKQLKAFQQEISLNHNKI-------EQIIAQ 2693
Query: 1677 GTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRV 1736
G +Q+++K + ++ AA E+L E L ++ Q++ +KLIR+
Sbjct: 2694 G----EQLIEKSEPLD---------AAIIEEELDE---LRRYCQEVFGRVERYHKKLIRL 2737
Query: 1737 SSQDYGRDLQGVQNLLKK---------HKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQ 1787
D DL + L+ H R L++ +P+ L +A+ L+ + +
Sbjct: 2738 PLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS--G 2795
Query: 1788 EEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNAL-AVRGD 1846
+ + W+ +L++ + +L +E+EE ++ L G
Sbjct: 2796 RDTPASVDSIPLEWDHDYDLSRDLESAMSRALP-------SEDEEGQDDKDFYLRGAVGL 2848
Query: 1847 CGDTLAATQSLLMKHEALEND-FAVHETR--VQNVCAQGEDI------LNKVLQEESQN- 1896
GD A + +AL++ F + +T +++ G ++ K+L E S +
Sbjct: 2849 SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSI 2908
Query: 1897 ---KEISSKIEALNEKTPSL----------AKAIAAWKL-----------QLEDDYAFQE 1932
K + K++ E P A I W+L ++ +Q+
Sbjct: 2909 DSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQ 2968
Query: 1933 FNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLK 1992
FN + + AW+ D E L+ L D LQ + + L + D +
Sbjct: 2969 FNSDLNSIWAWLGDTEEELE---------QLQRLELSTDIQTIELQIKKLKELQKAVDHR 3019
Query: 1993 DKLI-----------SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKA 2041
+I A +S+ +++R + + RW+++ R L + + Q
Sbjct: 3020 KAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQG- 3078
Query: 2042 EDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLA---SLARAQAD 2098
F E +H L E ++ +E V S + LQ H+ + L +Q
Sbjct: 3079 ---FHEMSH---GLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLR 3132
Query: 2099 FKCLLELDQQ--IKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNF 2156
L ++ Q + A G + LE K +I R + L KE +R +K
Sbjct: 3133 VASLQDMSCQLLVNAEG----------TDCLEA--KEKVHVIGNRLKLLLKEVSRHIKEL 3180
Query: 2157 EMCQEFEQNASTFLQW 2172
E + + W
Sbjct: 3181 EKLLDVSSSQQDLSSW 3196
Score = 134 bits (337), Expect = 1e-30
Identities = 446/2355 (18%), Positives = 873/2355 (37%), Gaps = 348/2355 (14%)
Query: 2 EQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRD 61
E P E + S VL AE + R + + Q +E++ ++ ++ LQ ++ +
Sbjct: 558 EADPAEQLALQSTLTVL--AERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCE 615
Query: 62 ADDLGKWIME-KVNILTDKS-YEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERF 119
AD+L W++ K + T S ++P +++ + Q++ E++ K +SEL E
Sbjct: 616 ADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL 675
Query: 120 TMGHS-AHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQE---------CAD 169
G + +E + +LR L LLEL D+ L Q +E
Sbjct: 676 LEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPG 735
Query: 170 ILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQ-VELVAKEGRVVEVNQYANECAEE- 227
+ EW+ T ++ E+ + E + VA G + + A E + +
Sbjct: 736 VQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 795
Query: 228 -NHPDLPLIQ---------SKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAI 277
PD+ L Q S ++++ WE L +QK L N
Sbjct: 796 GEKPDV-LSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLE------------ 842
Query: 278 QWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSD 337
+E+E VL S L++ L+ + AV S
Sbjct: 843 ---QEQEQVLYSRP--NRLLSGVPLYKGDVPTQDKSAVTS-------------------- 877
Query: 338 APQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNE------KTA 391
+ + L ++E + + S K Q+ + + S W+++
Sbjct: 878 ------LLDGLNQAFEEVS--SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 929
Query: 392 AINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKM 451
A+ +E T + E+L ++ E+D + F A N + D + + +
Sbjct: 930 ALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQA-------FPENGDNRDVIEDTL 982
Query: 452 EILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSA 511
L + L + ++R Q ++ L L +++ +V ++ + L N
Sbjct: 983 GCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQP 1042
Query: 512 EA----LLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDAL 567
A +Q+ ED + F A II + + KL + E K L D L
Sbjct: 1043 VAEQIEAIQQAEDGLKEFDA---GIIELKRRGDKLQVEQPSMQELSK-----LQDMYDEL 1094
Query: 568 REKAATRRRLLKESLLLQKLYEDS-DDLKNWINK-KKKLADDE-----DYKDIQNLKSRV 620
+RR L ++L L+ YE + DL + + ++K+A D+ ++IQ L +
Sbjct: 1095 MMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKH 1154
Query: 621 QKQ-QVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQK 679
++ Q E + + +T I +A T +E+ + +L+ ++
Sbjct: 1155 KEYFQGLESHMILTETLFRKIIS----------FAVQKETQFHTELMAQASAVLKRAHKR 1204
Query: 680 GTQL-HEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAE-----VQNRLRKHGLLE 733
G +L + + + ++L R LE VE + S GL E + +R+ + L+
Sbjct: 1205 GVELEYILETWSHLDEDQQELSRQLEVVESSIPS----VGLVEENEDRLIDRITLYQHLK 1260
Query: 734 SAVAARQDQV-DIL------------TDLAAYFEEIGHPDSKDIRARQESLVCRFEALKE 780
S++ Q ++ +L +DL + ++G + + L R E + +
Sbjct: 1261 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKEL-HRLETILK 1319
Query: 781 PLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILE 840
+ + DL+H +D E W Q+ S + ++L + LN +
Sbjct: 1320 HWTRYQSESADLIHWLQSAKDR--LEFWTQQ------SVTVPQELEMVRDHLNAFLEFSK 1371
Query: 841 NIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQ 900
+ + + GN+++ + S + ++ L Q L +Q
Sbjct: 1372 EVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLH-QLQ 1430
Query: 901 FQQYLA--DLHEAETWIREKEPIV----DNTNYGADEEAAGALLKKHEAFLLDLNSFGDS 954
+ + + E +WI E ++ DN +A L+K++ F +D+N
Sbjct: 1431 MDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDIN----- 1485
Query: 955 MKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDW 1014
C+Q V Q V+ + S R K D L ++NK W
Sbjct: 1486 ----------CKQLTVDFV-----NQSVLQISSQDVESKRS---DKTDFAEQLGAMNKSW 1527
Query: 1015 WKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEER 1074
+ QG+V ++ +L + + + EN + L E +
Sbjct: 1528 QIL-----QGLVT---------EKIQLLE--------GLLESWSEYENNVQCLKTWFETQ 1565
Query: 1075 RRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTN---- 1130
+RL Q+ + GD + +N + D+ +L K ++ + + N
Sbjct: 1566 EKRLKQQ-------HRIGD------QASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL 1612
Query: 1131 -EPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSA------- 1182
+ + D++ + L +EL W +L + + + LL S
Sbjct: 1613 IQNKKEDVSSIVMSTL-------------RELGQTWANLDHMVGQLKILLKSVLDQWSSH 1659
Query: 1183 ----HAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDK 1238
+ + EA + + +L A D ++Q LQ E ER L G
Sbjct: 1660 KVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD--NLQNLQDDLEKQERSLQKFG-- 1715
Query: 1239 VTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKA 1298
T + L E HP TE L E+N W +L ++ E L ++ +
Sbjct: 1716 ----SITNQLLKECHPPVTETLTNTLKEVNMRWNNL---LEEIAEQLQSSKALLQLWQRY 1768
Query: 1299 RDLQNWISSIGGMVS--SQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELI 1356
+D +S + EL + T +I + D ++D L
Sbjct: 1769 KDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLH 1828
Query: 1357 DSGHHASPEIE----KKLQAVKLERDD----LEKAWEKRKKILDQ-CLELQMFQGNCDQV 1407
+ G +++ +Q+ +L LE+A K++ L L+ + F + + +
Sbjct: 1829 ELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEAL 1888
Query: 1408 ESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYA 1467
E+W+V E L+ D S L + ++ ++L + DL+ E +
Sbjct: 1889 EAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE--LGYRLPL 1946
Query: 1468 KEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDES 1527
++ R+Q + W + +Q + +KL + L Q LE+ E W+ ++ T +
Sbjct: 1947 NDKEIKRMQNLNRHWSLISSQTTERFSKLQSF--LLQHQTFLEKCETWMEFLVQTEQKLA 2004
Query: 1528 YKDATNIQ---RKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQ 1584
+ + N Q + H+ F E+ R + +H +I G L+E D +E +L
Sbjct: 2005 VEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE-FNLKLTL 2063
Query: 1585 LKEHWDHLLERTNDKGKKLNEASRQ-QRFNTSIRDFEFWLSEAETL--LAMKDQARDLAS 1641
L W ++ R + ++ RQ QR+ WL E L + L
Sbjct: 2064 LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ 2123
Query: 1642 AGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQEL 1701
A L + Q E+ L ++ + + LL S + ++ + +QE
Sbjct: 2124 ARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAE------LAEIQEK 2177
Query: 1702 AAAHHEKLKEAYALFQF-FQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEG 1760
+ +L+E F +D + E I + L ++ + + + L Q+L H+ L
Sbjct: 2178 WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKL--RTFKKKLS--QSLPDHHEELHA 2233
Query: 1761 ELVAHEPAIQNV------LDMAEKLKD--KAAVGQEEIQL---RLAQFVEHWEKLKELAK 1809
E + + V L LKD A + ++I + R+ WE+L
Sbjct: 2234 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 2293
Query: 1810 ARGLKLEESL-EYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDF 1868
R ++ E L E+ F + +E W+ + + + GD L +K + E
Sbjct: 2294 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN--GDILIEEMIEKLKKDYQEEIA 2351
Query: 1869 AVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDD- 1927
E ++Q + GE + ES+ EI K+ +N++ L IAA +L++
Sbjct: 2352 IAQENKIQ-LQQMGERLAK--ASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETL 2408
Query: 1928 YAFQEFNWKADVVEAWIADKETSLKTN--GNGADLGDFLTLLAKQDTLDASLQSFQQERL 1985
A Q+ + + W+A E+ L + + + L +Q L ++ +
Sbjct: 2409 VAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEK-HSTGV 2467
Query: 1986 PEITDLKDKLI-----SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQK 2040
+ +L + L+ A + +I++ L +RW + S +E++L +++
Sbjct: 2468 ASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMS-------MERRLKIEE 2520
Query: 2041 AEDLFVEFAHKASALNNWCEKMEENLSEP-----VHCVSLNEIRQLQKDHEDFLASLARA 2095
L+ +F S +W + E + P ++ V+ E+++ + A
Sbjct: 2521 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFE----------AFQ 2570
Query: 2096 QADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQ---ELQKEEA-- 2150
+ +CL +L+ + + Y L E + L ++ E Q LQK
Sbjct: 2571 RQVHECLTQLE-------LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSI 2623
Query: 2151 -RQVKNF-EMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQA 2208
R++K+F +EFE + L W+ E + E ++++++ K Q+EI
Sbjct: 2624 LRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC-DVQAKIKQLKAFQQEISL 2682
Query: 2209 MKRQLTKIVDLGDNL 2223
++ +I+ G+ L
Sbjct: 2683 NHNKIEQIIAQGEQL 2697
Score = 121 bits (304), Expect = 7e-27
Identities = 247/1260 (19%), Positives = 512/1260 (40%), Gaps = 157/1260 (12%)
Query: 1090 EAGDMLEWIQEKK---------AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKV 1140
E+ D++ W+Q K + EL+ V + F EF K+++ +
Sbjct: 1327 ESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 1386
Query: 1141 ADDLLFEGLLTPEGAQIRQELN---SRWGSL--------QRLADEQRQLLGSAHAVE--- 1186
+ LL L + A +R EL+ S+W L ++L Q L S HA+
Sbjct: 1387 GNQLL--RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVM 1444
Query: 1187 --------VFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDK 1238
V ++ D+ K I K ++ ++++GF+ D+
Sbjct: 1445 SWISLMENVIQKDEDNIKNSIGYK--------------AIHEYLQKYKGFKIDINCKQLT 1490
Query: 1239 VTILGETAERLS----ESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNE-AQKFYL 1293
V + ++ ++S ES D Q +N++W+ LQG ++ + L + +
Sbjct: 1491 VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSE 1550
Query: 1294 FLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSA 1353
+ + + L+ W + + Q D ++ L+ Q+ ++A+ + +E
Sbjct: 1551 YENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGL 1610
Query: 1354 ELI-DSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCL-ELQMFQGNCDQVESWM 1411
LI + S + L+ + +L+ + K +L L + + D++ S++
Sbjct: 1611 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYL 1670
Query: 1412 VARENSLRSDDKSSLDSLEALMKKRDDLDKA---ITAQEGKITDLEHFAESLIADEH-YA 1467
+ SL S + SLEA+ + D+L + QE + L+ + H
Sbjct: 1671 MEARYSL-SRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPV 1729
Query: 1468 KEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDES 1527
E + L+ V RW L ++ ++ L Q Y+D + + +E
Sbjct: 1730 TETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL 1789
Query: 1528 YKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKE 1587
K ATN K + A + ++ + G+ + +SL + E EQLK+
Sbjct: 1790 LKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLF----------FLHELGEQLKQ 1836
Query: 1588 HWD----------------HL--LERTNDKGKKLNEAS--RQQRFNTSIRDFEFWLSEAE 1627
D HL LE+ K + +A + F S+ E W+ EAE
Sbjct: 1837 QVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE 1896
Query: 1628 TLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKK 1687
+L +D + + + ++ + L+ +ML DL+ L E L D+ +K+
Sbjct: 1897 EILQGQDPSHS-SDLSTIQERMEELKGQMLKFSSMAPDLDRLNE--LGYRLPLNDKEIKR 1953
Query: 1688 KDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQG 1747
N+N+ + + KL+ Q F L+ E+W+E + + Q ++ G
Sbjct: 1954 MQNLNRHWSLISSQTTERFSKLQSFLLQHQTF--LEKCETWME--FLVQTEQKLAVEISG 2009
Query: 1748 -VQNLLKK---HKRLEGELVAHEPAIQNVLDMAEKLKDKAAV-GQEEIQLRLAQFVEHWE 1802
Q+LL++ H+ + E+ + + + +++ ++L ++ V ++E L+L W+
Sbjct: 2010 NYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQ 2069
Query: 1803 -KLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVR--GDCGDTLAATQSLLM 1859
++ + RG+ + ++ ++ + AE+ W+ E + L + G L ++L
Sbjct: 2070 GVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFD 2129
Query: 1860 KHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAA 1919
+ + E F + G+ +L + + + +++ + EK S + +
Sbjct: 2130 EVQFKEKVFLRQQGSYILTVEAGKQLL--LSADSGAEAALQAELAEIQEKWKSASMRLEE 2187
Query: 1920 WKLQLEDDYAFQEFNWKADVVEAWIADKETSLKT--NGNGADLGDFLTLLAKQD----TL 1973
K +L AF +W + E IAD L+T L D L + L
Sbjct: 2188 QKKKL----AFLLKDW--EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKEL 2241
Query: 1974 DASLQSFQQERLPEITDLKDKL---ISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQK 2030
+ ++ S+ + L +++ LKD L ISA + + ER L ++WE+L ++ RQ+
Sbjct: 2242 ENAVGSWTDD-LTQLSLLKDTLSAYISA--DDISILNERVELLQRQWEELCHQLSLRRQQ 2298
Query: 2031 LLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLA 2090
+ E+ + + F+ K L W +ME +S+ + I +L+KD+++
Sbjct: 2299 IGERL-------NEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQE--- 2348
Query: 2091 SLARAQADFKCLLELDQQIKALGVPS--SPYTWLTVEVLERTWKHLSDIIEEREQELQKE 2148
+A AQ + L ++ +++ S S + +V +R W+HL D+I R ++L+
Sbjct: 2349 EIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDR-WQHLLDLIAARVKKLK-- 2405
Query: 2149 EARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRK--QKEI 2206
+ Q+ ++N S+ W+ + + + E Q + N+++ Q++I
Sbjct: 2406 -----ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 2460
Query: 2207 QAMKRQLTKIVDLGDNL--------EDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQ 2258
+ + +++L + L DA I+ +T L ++W + + + + +E+
Sbjct: 2461 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 2520
Score = 107 bits (266), Expect = 2e-22
Identities = 440/2253 (19%), Positives = 874/2253 (38%), Gaps = 330/2253 (14%)
Query: 54 HLQVFKRDADDLGKWIMEKVNILTDKS--YEDPTNIQGKYQKHQSLEAEVQTKSRLMSEL 111
HL+ + + + KWI EK +L + + + ++ +Y HQ+L ++ + SEL
Sbjct: 52 HLEEYNEMLELILKWI-EKAKVLAHGTIAWNSASQLREQYILHQTL---LEESKEIDSEL 107
Query: 112 EKTREE-RFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALK-FQQYVQECAD 169
E E+ ++ E+ + EL + L ++ + L A K +++ E
Sbjct: 108 EAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKK 167
Query: 170 ILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENH 229
+ + +A TS E+G + ++ H++ ++E + + + V++ Q A E+
Sbjct: 168 LQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVV 227
Query: 230 PDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAA-NLQRFKRDVTEAIQWIK------E 282
LPL + A RL+ A+Q+ + A +++++++ Q I+ E
Sbjct: 228 ASLPLCHAALRLQEEA-SRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIE 286
Query: 283 KEPVLTS--EDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLT-LSHPSDAP 339
+PV TS ++ + E L KG + +A ++ K K L KA+ T L ++
Sbjct: 287 DKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVE 346
Query: 340 QIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSG--WMNEKTAAINADE 397
+ E EDL E + + + H S E SG N + ++ A
Sbjct: 347 GLAEGTEDL--DGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR 404
Query: 398 LPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVRE-------- 449
P+ VA + +++ +I Y +T ++ + AS E E
Sbjct: 405 SPSPVANTDASVNQ------DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT 458
Query: 450 -KMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAF-LENEDLGNS 507
K+ L +W L + E+ R + L+ Y+DS Q S ++ EA L+ +
Sbjct: 459 AKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQ--SISTKMEAIELKLSESPEP 516
Query: 508 LGSAEALLQKHEDF-EEAFTAQEEKIITVDKTATKLIGD----DHYDSENIKAIRDGLLA 562
S E+ + +H+ +E Q+E A +L+ + D + +++ L
Sbjct: 517 GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE 576
Query: 563 RRDALREKAATRRRLLKESL-----------LLQKLYEDSDDLKNWINKKKKLAD----- 606
R +R KA+ +R+LL+E L LQ+ ++D+L +W+ K D
Sbjct: 577 RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP 636
Query: 607 -------DEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVT 659
+ D QN+ ++++ V EL+V+ L ++EG + D
Sbjct: 637 PKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENL---------LLEGKAHTKDEAE 687
Query: 660 TRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVT-SEDYGKG 718
++ L LLE + LH+ +QL + A++ + DV+ T S +
Sbjct: 688 QLAGKLRRLKGSLLELQRA----LHD--KQLNMQGTAQEKEE--SDVDLTATQSPGVQEW 739
Query: 719 LAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEAL 778
LA+ + + ++ Q Q ++ +LA + + + +R E ++ + A
Sbjct: 740 LAQARTTWT-----QQRQSSLQQQKELEQELAEQKSLL-----RSVASRGEEILIQHSAA 789
Query: 779 KEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVI 838
+ +K D+L +L E E S+ + + + + + +
Sbjct: 790 ETSGDAGEKP--DVLSQELG-----------MEGEKSSAEDQMRMKWESLHQEFSTKQKL 836
Query: 839 LENIASHEPRIQEITERGNKMVE-----EGHFAAED---VASRVKSLNQNMESLRARA-- 888
L+N+ E Q + R N+++ +G +D V S + LNQ E + +++
Sbjct: 837 LQNVLEQEQE-QVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGG 895
Query: 889 ARRQNDLEANVQFQQYLAD-LHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLD 947
A+RQ+ + +Q L D + TW+ + E + EE L + E D
Sbjct: 896 AKRQS-----IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQ-EILAKD 949
Query: 948 LNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLL 1007
+ + M +N + QA P G R E T+ G +L L
Sbjct: 950 IKEMSEEMDKNKNLFS-----QAFPENG-------------DNRDVIEDTL--GCLLGRL 989
Query: 1008 SSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSL 1067
S ++ V + H + +E I Q ++ + SL
Sbjct: 990 SLLDS-----------------VVNQRCH--------QMKERLQQILNFQNDLKVLFTSL 1024
Query: 1068 LDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELD-DVWELQKKFDEFQKD 1126
D ++L + + + +E IQ+ AE+ E D + EL+++ D+ Q +
Sbjct: 1025 ADNKYIILQKLANVFEQ-----PVAEQIEAIQQ--AEDGLKEFDAGIIELKRRGDKLQVE 1077
Query: 1127 LNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVE 1186
+P +++++K+ D +++ L+ G++ R LN +L + +R L A +E
Sbjct: 1078 ----QPSMQELSKLQD--MYDELMMIIGSR-RSGLNQ---NLTLKSQYERALQDLADLLE 1127
Query: 1187 VFHRE-ADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKV--TILG 1243
+ A D K + K + D + F +G E ++ L + + I+
Sbjct: 1128 TGQEKMAGDQKIIVSSKEEIQQLLDKHKEYF---------QGLESHMI-LTETLFRKIIS 1177
Query: 1244 ETAERLSESHPD----ATEDLQR---QKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLS 1296
++ ++ H + A+ L+R + +EL E +D++E + +
Sbjct: 1178 FAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEV------ 1231
Query: 1297 KARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELI 1356
+++ I S+G + +++ D I L +H + + E + +Q L+D LI
Sbjct: 1232 ----VESSIPSVGLVEENEDRLID----RITLYQHLKSSLN-EYQPKLYQVLDDGKRLLI 1282
Query: 1357 D-SGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARE 1415
S ++ + + + + K + + IL +Q + W+ + +
Sbjct: 1283 SISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR---YQSESADLIHWLQSAK 1339
Query: 1416 NSLRSDDKSSLDSLEALMKKRDDLD------KAITAQEGKITDLEHFAESLIADEHYAKE 1469
+ L + S+ + L RD L+ K + AQ + + L+ +
Sbjct: 1340 DRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTA 1399
Query: 1470 EIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRD-LEELEEWISEMLPTACDESY 1528
+ + L R+ +W L + + KL K R + E+ WIS M
Sbjct: 1400 TLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVI----Q 1455
Query: 1529 KDATNIQR--------KYL-KHQTFAHEVDGRSEQV----HGVINLGNSLIECSACDGNE 1575
KD NI+ +YL K++ F +++ + V V+ + + +E D +
Sbjct: 1456 KDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTD 1515
Query: 1576 EAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQ-QRFNTSIRDFEFWLSEAETLLAMKD 1634
A EQL + + W L +K + L + +++ + W E L +
Sbjct: 1516 FA--EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH 1573
Query: 1635 QARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK-DNVNK 1693
+ D AS N LK Q LE + A+E ++ + L+ + +V IV + +
Sbjct: 1574 RIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQ 1633
Query: 1694 RFLNVQELAAAHHEKLKEAYALFQFFQ-DLDDEESWIEEKLIRVSS-QDYGRDLQGVQNL 1751
+ N+ + LK + + D S++ E +S + L+ VQ
Sbjct: 1634 TWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQ 1693
Query: 1752 LKKHKRLEGELVAHEPAIQNVLDMAEK-LKDKAAVGQEEIQLRLAQFVEHWEK-LKELAK 1809
+ + L+ +L E ++Q + + LK+ E + L + W L+E+A+
Sbjct: 1694 VDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAE 1753
Query: 1810 ARGLKLEESLEYLQFMQ-----------NAEEEEAWINEKNALAVRGDCGDTLAATQ--- 1855
+L+ S LQ Q +++E NE A D D AT
Sbjct: 1754 ----QLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQD 1809
Query: 1856 -SLLMKHEALEND--FAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPS 1912
+ L+K D F +HE GE + +V + S I S +L++ +
Sbjct: 1810 CNDLLKGLGTVKDSLFFLHEL--------GEQLKQQV--DASAASAIQSDQLSLSQHLCA 1859
Query: 1913 LAKAIAAWKLQLEDDYA-FQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQD 1971
L +A+ + L+ ++ F + +EAWI + E L+ + + D T+ + +
Sbjct: 1860 LEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQ-GQDPSHSSDLSTIQERME 1918
Query: 1972 TLDASLQSFQQ-----ERLPEI---TDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEA 2023
L + F +RL E+ L DK I N + R+ +L+ Q E
Sbjct: 1919 ELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLN-----RHWSLIS--SQTTER 1971
Query: 2024 SAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQK 2083
+ + LL+ Q L+K E ++EF + +K+ +S + + + Q+
Sbjct: 1972 FSKLQSFLLQHQTFLEKCE-TWMEFLVQTE------QKLAVEISG-----NYQHLLEQQR 2019
Query: 2084 DHEDFLASL-ARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEERE 2142
HE F A + +R Q +++ + ++ V L + +L W+ + ++R
Sbjct: 2020 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 2079
Query: 2143 QELQKEEARQVKNFEMCQEFEQNASTFLQWILE 2175
+ + Q + + A +W++E
Sbjct: 2080 GIIDSQ-------IRQWQRYREMAEKLRKWLVE 2105
Score = 95.1 bits (235), Expect = 7e-19
Identities = 322/1712 (18%), Positives = 637/1712 (37%), Gaps = 254/1712 (14%)
Query: 83 DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHI----EELRH 138
D ++Q + Q LE ++ K + E+EK + + + E+ + + EL
Sbjct: 1577 DQASVQNALKDCQDLEDLIKAKEK---EVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQ 1633
Query: 139 LW----------DLLLELTLEKGDQLLRAL-KFQQYVQECADILEWI----GDKEAIATS 183
W +LL+ L++ A K Y+ E L G EA+
Sbjct: 1634 TWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQ 1693
Query: 184 VELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQN--- 240
V+ ++ Q +L +E + + N+ +E HP P+ ++ N
Sbjct: 1694 VD-------------NLQNLQDDLEKQERSLQKFGSITNQLLKECHP--PVTETLTNTLK 1738
Query: 241 EVNAAWERL-RGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEP-------VLTSEDY 292
EVN W L +A Q Q + + QR+K + ++++E T++D
Sbjct: 1739 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 1798
Query: 293 GKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSW 352
D VA+ L + L + D + L E+L DA ++ D +S
Sbjct: 1799 ADDEVAT--WIQDCNDLLKGLGTVKDSLFFLHELGEQL--KQQVDASAASAIQSDQLSLS 1854
Query: 353 EHIRALATS---RYEKLQATYW-YHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVL 408
+H+ AL + + LQA Y F+ + L W+ E + + P+ + +
Sbjct: 1855 QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQD-PSHSSDLSTI 1913
Query: 409 LDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDER 468
+R ++ K ++ + D + + +D+ ++M+ L+ +W+ + ER
Sbjct: 1914 QERMEELKGQMLKFSSMAPDLDRLNE--LGYRLPLNDKEIKRMQNLNRHWSLISSQTTER 1971
Query: 469 HRQYEQCLDFHLFYRDSEQVDSWMS---RQEAFLENEDLGNSLGSAEALLQKHEDFEEAF 525
+ + L H + E+ ++WM + E L E GN E + HE F+
Sbjct: 1972 FSKLQSFLLQHQTFL--EKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ-RAHELFQAEM 2028
Query: 526 TAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARR-DALREKAATRRRLLKESLLL 584
++++ + ++ +L+ D + ++ LL+ + + +A RR ++ +
Sbjct: 2029 FSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQ 2088
Query: 585 QKLYED-SDDLKNWINKKKKLADDE------DYKDIQNLKSRVQ-KQQVFEKELAVNKTQ 636
+ Y + ++ L+ W+ + L + + L VQ K++VF ++ +
Sbjct: 2089 WQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG---SY 2145
Query: 637 LENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQF---- 692
+ ++ Q ++ A + L+E+ W K +L E ++L F
Sbjct: 2146 ILTVEAGKQLLLSADSGAEAALQAELAEIQEKW-------KSASMRLEEQKKKLAFLLKD 2198
Query: 693 ----ENNAEDLQRWLEDVEWQVTSE--DYGKGLAEVQNRLRKHGLLESAVAARQD---QV 743
E D L + +++ D+ + L Q R ++ LE+AV + D Q+
Sbjct: 2199 WEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE---LENAVGSWTDDLTQL 2255
Query: 744 DILTD-LAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT 802
+L D L+AY I D + R E L ++E L L+ R++++ + L+ + +
Sbjct: 2256 SLLKDTLSAY---ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 2312
Query: 803 EDEEA-WIQETEPSATST----------YLGKDLIASKKLLNRHRVILENI------ASH 845
E W+ + E + L KD + +++ L+ + ASH
Sbjct: 2313 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASH 2372
Query: 846 EPRIQEITERGNKMVEEGHFAAEDVASRVK----------SLNQNMESLRARAARRQNDL 895
E + EI + K+ + + +A+RVK L++NM SLR A +++L
Sbjct: 2373 ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 2432
Query: 896 EANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSM 955
+ + + E + + E++ + + ++L E L D +
Sbjct: 2433 AKPIVYDS--CNSEEIQRKLNEQQEL--QRDIEKHSTGVASVLNLCEVLLHDCD------ 2482
Query: 956 KALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWW 1015
A A QQA + R + + R E T + S +DW
Sbjct: 2483 -ACATDAECDSIQQA--TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 2539
Query: 1016 KVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLL------- 1068
K + + +A +E +R+ +TQ E I QYR L
Sbjct: 2540 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ-LELINKQYRRLARENRTDS 2598
Query: 1069 ---------------DRAEERRRRLLQRYNEFLLAYE-----AGDMLEWIQEKKAENTGV 1108
D ++R +L+R F+ E +L W+ E + T +
Sbjct: 2599 ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 2658
Query: 1109 ELDDVWELQKKFDE---FQKDLNTNEPRLRDINKVADDL------LFEGLLTPEGAQIRQ 1159
E ++Q K + FQ++++ N ++ I + L L ++ E ++R+
Sbjct: 2659 EHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 2718
Query: 1160 ELNSRWGSLQR---------LADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAAD 1210
+G ++R L D++ L S +E+ A ++ +L +
Sbjct: 2719 YCQEVFGRVERYHKKLIRLPLPDDEHDL--SDRELELEDSAALSDLHWHDRSADSLLSPQ 2776
Query: 1211 PGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHP-DATEDLQRQKMELNE 1269
P S+L A R E RD D + L H D + DL+ M
Sbjct: 2777 PSSNLSLSLAQPLRSERSGRDTPASVDSIP--------LEWDHDYDLSRDLE-SAMSRAL 2827
Query: 1270 AWEDLQGRTKDRKESLNEAQKFYL-----FLSKARDLQNWISSIGGMVSSQELAEDLTGI 1324
ED +G+ + + FYL L++ I +G + T
Sbjct: 2828 PSEDEEGQ---------DDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQT-- 2876
Query: 1325 EILLERHQEHRADMEAEAPTFQALEDFSAELIDS----GHHASPEIEKKLQAVKLERDDL 1380
E ++ +++ + L + IDS H E E V L +
Sbjct: 2877 ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 2936
Query: 1381 EKA-----WE--------KRKKILDQCLELQMFQGNCDQVESWMVARENSL----RSDDK 1423
+ A WE K ++ + Q F + + + +W+ E L R +
Sbjct: 2937 QTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELS 2996
Query: 1424 SSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWK 1483
+ + ++E +KK +L KA+ ++ I + + + ++ RL ++ RW
Sbjct: 2997 TDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWD 3056
Query: 1484 ALKAQLIDERTKLGDYANLKQFYRD--------LEELEEWISEMLPTACDESYKDATNIQ 1535
+ + L + R L D Q + + LE ++ +E++P +S DA +Q
Sbjct: 3057 RVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPI---DSNLDAEILQ 3113
Query: 1536 RKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLER 1595
+ + HE+ +V + ++ L+ + EA KE++ + LL+
Sbjct: 3114 DHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLKLLLKE 3172
Query: 1596 TNDKGKKLNEASRQQRFNTSIRDFEFWLSEAE 1627
+ + + E + ++S +D W S E
Sbjct: 3173 VS---RHIKELEKLLDVSSSQQDLSSWSSADE 3201
Score = 87.4 bits (215), Expect = 2e-16
Identities = 190/1051 (18%), Positives = 409/1051 (38%), Gaps = 129/1051 (12%)
Query: 2 EQFPKETVVES---SGPKVLETAE-----EIQERRQEVLTRYQSFKERVAERGQKLEDSY 53
E F ++ ++ S G ++LE + E + + ++Q R +R ++
Sbjct: 2027 EMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQI 2086
Query: 54 HL-QVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSE-- 110
Q ++ A+ L KW++E + P +Q + ++L EVQ K ++
Sbjct: 2087 RQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQ----QARTLFDEVQFKEKVFLRQQ 2142
Query: 111 ------LEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYV 164
+E ++ + A +A + E++ W E+ +L LK
Sbjct: 2143 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK----- 2197
Query: 165 QECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANEC 224
+W ++ IA S+E +++ L + D EL A++ R E+
Sbjct: 2198 -------DWEKCEKGIADSLEKLRTFKKK--LSQSLPDHHEELHAEQMRCKELENAVGSW 2248
Query: 225 AEE---------------NHPDLPLIQSKQNEVNAAWERL-RGLALQRQKALSNAANLQR 268
++ + D+ ++ + + WE L L+L+RQ+
Sbjct: 2249 TDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV 2308
Query: 269 FKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAE 328
F E +W+ + E ++ D++ E + K + +A+ + +L E
Sbjct: 2309 FSEKNKELCEWLTQMESKVSQNG---DILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGE 2365
Query: 329 KLT-LSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQAT-YWYHRFSSDFDELSGWM 386
+L SH S A +I+ + W+H+ L +R +KL+ T + + L W+
Sbjct: 2366 RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL 2425
Query: 387 NEKTAAINADELPTDVAGGEVL---LDRHQQHKHEIDSYDDRFQSADETGQDLVN----- 438
+ + A + D E + L+ Q+ + +I+ + S + L++
Sbjct: 2426 AHIESEL-AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDAC 2484
Query: 439 ANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLD-FHLFYRDSEQVDSWMSRQE- 496
A D +++ LD W + + ER + E+ + F D + + W+ E
Sbjct: 2485 ATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 2544
Query: 497 --AFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSE-NI 553
AF + + ++ E L+K E F+ ++ ++K +L ++ DS ++
Sbjct: 2545 TAAFPSSSGVIYTVAKEE--LKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 2602
Query: 554 KAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDS-DDLKNWINKKKKLADDEDYKD 612
K + R D L+++ + R LK + ++ +E + D + W+ + + ++
Sbjct: 2603 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 2662
Query: 613 IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGH-YASDNVTTRLSEVASLWEE 671
++++++++ + F++E+++N ++E I G+++IE + + L E+ +E
Sbjct: 2663 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 2722
Query: 672 LLEATKQKGTQL---------HE-ANQQLQFENNAEDLQRWLEDVEWQVTSED------- 714
+ ++ +L H+ ++++L+ E++A L D+ W S D
Sbjct: 2723 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAA-----LSDLHWHDRSADSLLSPQP 2777
Query: 715 -------YGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDL------AAYFEEIGHPDS 761
+ L ++ ++S D+ DL A E+ D
Sbjct: 2778 SSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD 2837
Query: 762 KDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYL 821
KD R + + E + K LD Q+ + TE+ T P ++Y
Sbjct: 2838 KDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQI--QQTENIIRSKTPTGPELDTSYK 2895
Query: 822 GKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNM 881
G KLL ++++ E +++E E G ++ +
Sbjct: 2896 G-----YMKLLGECSSSIDSVKRLEHKLKEEEES-----LPGFVNLHSTETQTAGVIDRW 2945
Query: 882 ESLRARAARRQNDLEANVQ-FQQYLADLHEAETWIREKEPIVD---NTNYGADEEAAGAL 937
E L+A+A ++ ++ N+Q +QQ+ +DL+ W+ + E ++ D +
Sbjct: 2946 ELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQ 3005
Query: 938 LKKHEAFLLDLNSFGDSMKALRNQANACQQQ 968
+KK L +L D KA+ N C +
Sbjct: 3006 IKK----LKELQKAVDHRKAIILSINLCSPE 3032
Score = 53.5 bits (127), Expect = 2e-06
Identities = 50/211 (23%), Positives = 94/211 (44%), Gaps = 15/211 (7%)
Query: 63 DDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELE-KTREER--- 118
DD I + NI+ K+ P + Y+ + L E + + LE K +EE
Sbjct: 2867 DDSRFQIQQTENIIRSKTPTGP-ELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 2925
Query: 119 --FTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRAL-KFQQYVQECADILEWIG 175
F HS +T I+ W+LL L K ++ + L K+QQ+ + I W+G
Sbjct: 2926 PGFVNLHSTETQTAGVIDR----WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLG 2981
Query: 176 DKEAIATS---VELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDL 232
D E +EL D + E+ KK ++ Q + ++ ++ +N + E + + +
Sbjct: 2982 DTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKES 3041
Query: 233 PLIQSKQNEVNAAWERLRGLALQRQKALSNA 263
+Q + +++N W+R+ L + + L +A
Sbjct: 3042 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDA 3072
Score = 40.0 bits (92), Expect = 0.028
Identities = 65/336 (19%), Positives = 143/336 (42%), Gaps = 28/336 (8%)
Query: 564 RDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQ 623
+ +R+ +L + + L++ E + + WI K K LA N S++++Q
Sbjct: 33 QQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTI---AWNSASQLREQ 89
Query: 624 QVFEKELAVNKTQLENIQKTGQEMIE--GGHYASDNVTTRLSEVASLWEELLEATKQKGT 681
+ + L ++++ + E ++ Y ++ ++ +++E+ EEL + K +
Sbjct: 90 YILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQ 149
Query: 682 QLHEANQQLQ-FENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLE------- 733
L +A + ++ FE + LQ LE + +TS + G+ + Q R+H L E
Sbjct: 150 NLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPK 209
Query: 734 -SAVAARQDQVDILTDLAAYFEEIGHPD---SKDIRARQESLVCRFEALKEPLATRKKKL 789
AV Q + I D+ A + H ++ Q + + + ++ + ++
Sbjct: 210 VQAVQLCQSALRIPEDVVASL-PLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYE 268
Query: 790 LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849
++ HLQ + E E +P ATS ++L A ++RH + + I ++ +I
Sbjct: 269 QEMKHLQQLIEGAHRE----IEDKPVATSNI--QELQAQ---ISRHEELAQKIKGYQEQI 319
Query: 850 QEITERGNKM-VEEGHFAAEDVASRVKSLNQNMESL 884
+ + + ++ H + V+ L + E L
Sbjct: 320 ASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDL 355
>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
[Homo sapiens]
Length = 8749
Score = 146 bits (368), Expect = 3e-34
Identities = 433/2252 (19%), Positives = 874/2252 (38%), Gaps = 325/2252 (14%)
Query: 133 IEELRHLWDLLLELTLEKGDQ-------LLRALKFQQYVQECADILEWIGDKEAIATSVE 185
++EL L D+ EL + G + L ++++ +Q+ AD+LE +K A +
Sbjct: 6486 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 6545
Query: 186 LGEDWERTEVLHKKFEDFQ---VELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEV 242
+ E ++L K E FQ ++ E ++ +A + + H +L +
Sbjct: 6546 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTEL------MAQA 6599
Query: 243 NAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGL 302
+A +R ++ + L ++L +++++ ++ ++ P + + +D +
Sbjct: 6600 SAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRIT 6659
Query: 303 FHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSD--APQIQEMKEDLVSSW----EHIR 356
+ H L+ +L K+ ++ ++L +S Q+ ++ E +S+ + +
Sbjct: 6660 LYQH--LKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELH 6717
Query: 357 ALAT-----SRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411
L T +RY+ A H S D L W + E+ D L+
Sbjct: 6718 RLETILKHWTRYQSESADL-IHWLQSAKDRLEFWTQQSVTVPQELEMVRDH------LNA 6770
Query: 412 HQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQ 471
+ E+D+ S TG L+ + +R ++ +D+ WT LL +
Sbjct: 6771 FLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEK 6830
Query: 472 YEQCLDFHLFYRDS-EQVDSWMSRQEAFLENED--LGNSLG--SAEALLQKHEDFEEAFT 526
Q L R + +V SW+S E ++ ++ + NS+G + LQK++ F+
Sbjct: 6831 LHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDIN 6890
Query: 527 AQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESL-LLQ 585
++ +TVD ++ D E+ ++ + + A+ + + L+ E + LL+
Sbjct: 6891 CKQ---LTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLE 6947
Query: 586 KLYEDSDD-------LKNWI-NKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQL 637
L E + LK W ++K+L D ++++ ++ Q E + + ++
Sbjct: 6948 GLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEV 7007
Query: 638 ENIQKTGQEMIEG-GHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNA 696
E I++ G +I+ S V + L E+ W L Q L
Sbjct: 7008 EKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSV---------- 7057
Query: 697 EDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFE-- 754
L +W +V + L E + L + LL ++ A Q QVD L +L E
Sbjct: 7058 --LDQWSSH---KVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ 7112
Query: 755 ----------------EIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLI 798
E P ++ + + + R+ L E +A + + LL L
Sbjct: 7113 ERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQR 7172
Query: 799 CRD--------TEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQ 850
+D + +E E +AT+ + D +A+ + +L+ + + + +
Sbjct: 7173 YKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVAT--WIQDCNDLLKGLGTVKDSLF 7230
Query: 851 EITERGNKMVEE-GHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANV-QFQQYLADL 908
+ E G ++ ++ AA + S SL+Q++ +L ++Q L+A V ++ + L
Sbjct: 7231 FLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSL 7290
Query: 909 HEAETWIREKEPIV--DNTNYGAD--------EEAAGALLK-KHEAFLLD-LNSFG---- 952
E WI E E I+ + ++ +D EE G +LK A LD LN G
Sbjct: 7291 EALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP 7350
Query: 953 ---DSMKALRNQANACQQQQAAPVEGVAGEQRVMALY-----------DFQARSPREVTM 998
+K ++N + E + Q + + +F ++ +++ +
Sbjct: 7351 LNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV 7410
Query: 999 K-KGDVLTLLSSIN-KDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQR 1056
+ G+ LL + ++ E Q I+ ++ + D +L Q + ++ +
Sbjct: 7411 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII-----DGQRLLEQGQVDDRDEFNLK 7465
Query: 1057 QEQIENQYRSLLDRAEERRR------RLLQRYNEFLLAYEAGDMLEWIQEKK-------- 1102
+ NQ++ ++ RA++RR R QRY E A + +W+ E
Sbjct: 7466 LTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM-----AEKLRKWLVEVSYLPMSGLG 7520
Query: 1103 -----AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQI 1157
+ D+V +K F Q + + AD E L E A+I
Sbjct: 7521 SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGA-EAALQAELAEI 7579
Query: 1158 RQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFS 1217
+++ S + RL +++++L E + D+ E++ + LS + P
Sbjct: 7580 QEKWKS---ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHH-EE 7635
Query: 1218 VQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKME-LNEAWEDLQG 1276
+ A Q R + E + D +T L + LS + +++E L WE+L
Sbjct: 7636 LHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH 7695
Query: 1277 RTKDRKESLNE-AQKFYLFLSKARDLQNWISSIGGMVSSQE--LAEDLTGIEILLERHQE 1333
+ R++ + E ++ +F K ++L W++ + VS L E++ IE L + +QE
Sbjct: 7696 QLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEM--IEKLKKDYQE 7753
Query: 1334 HRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKR-KKILD 1392
A + Q + + A+ S + EIE KL V L R KK+ +
Sbjct: 7754 EIAIAQENKIQLQQMGERLAKA--SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKE 7811
Query: 1393 QCLELQMFQGNCDQVESWMVARENSLRSD---DKSSLDSLEALMKKRDDLDKAITAQEGK 1449
+ +Q N + +W+ E+ L D + + ++ + ++ +L + I
Sbjct: 7812 TLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7871
Query: 1450 ITDLEHFAESLIAD-EHYAKEEIATRLQ---RVLD-RWKALKAQLIDERTKLGDYANL-K 1503
+ + + E L+ D + A + +Q R LD RW+ + A ++ R K+ + L +
Sbjct: 7872 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 7931
Query: 1504 QFYRDLEELEEWISEMLPTACDES-----YKDATNIQRKYLKHQTFAHEVDGRSEQVHGV 1558
+F D E+W+ TA S Y A +K+ Q HE + E ++
Sbjct: 7932 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
Query: 1559 I-NLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNE-ASRQQRFNTSI 1616
L SAC ++K+ + + + WD+L +R ++L +++ F T+
Sbjct: 7992 YRRLARENRTDSAC-----SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 8046
Query: 1617 RDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSS 1676
WL+E + L + + +K+ + ++E+ + + E +++
Sbjct: 8047 DSILVWLTEMDLQLTNIEHFSE-CDVQAKIKQLKAFQQEISLNHNKI-------EQIIAQ 8098
Query: 1677 GTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRV 1736
G +Q+++K + ++ AA E+L E L ++ Q++ +KLIR+
Sbjct: 8099 G----EQLIEKSEPLD---------AAIIEEELDE---LRRYCQEVFGRVERYHKKLIRL 8142
Query: 1737 SSQDYGRDLQGVQNLLKK---------HKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQ 1787
D DL + L+ H R L++ +P+ L +A+ L+ + + G+
Sbjct: 8143 PLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS-GR 8201
Query: 1788 E---EIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQ-----FMQNA---------EE 1830
+ + ++ ++ ++L A L E Q +++ A E
Sbjct: 8202 DTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPES 8261
Query: 1831 EEAWINEKNALAVRGDCGDTLAATQSLLMKHEALEND-FAVHETR--VQNVCAQGEDI-- 1885
EA++ + A++ GD A + +AL++ F + +T +++ G ++
Sbjct: 8262 PEAYV-KLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDT 8320
Query: 1886 ----LNKVLQEESQN----KEISSKIEALNEKTPSL----------AKAIAAWKL----- 1922
K+L E S + K + K++ E P A I W+L
Sbjct: 8321 SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQA 8380
Query: 1923 ------QLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDAS 1976
++ +Q+FN + + AW+ D E L+ L D
Sbjct: 8381 LSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELE---------QLQRLELSTDIQTIE 8431
Query: 1977 LQSFQQERLPEITDLKDKLI-----------SAQHNQSKAIEERYAALLKRWEQLLEASA 2025
LQ + + L + D + +I A +S+ +++R + + RW+++
Sbjct: 8432 LQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLE 8491
Query: 2026 VHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDH 2085
R L + + Q F E +H L E ++ +E V S + LQ H
Sbjct: 8492 EWRGLLQDALMQCQG----FHEMSH---GLLLMLENIDRRKNEIVPIDSNLDAEILQDHH 8544
Query: 2086 EDFLA---SLARAQADFKCLLELDQQ--IKALGVPSSPYTWLTVEVLERTWKHLSDIIEE 2140
+ + L +Q L ++ Q + A G + LE K +I
Sbjct: 8545 KQLMQIKHELLESQLRVASLQDMSCQLLVNAEG----------TDCLEA--KEKVHVIGN 8592
Query: 2141 REQELQKEEARQVKNFEMCQEFEQNASTFLQW 2172
R + L KE +R +K E + + W
Sbjct: 8593 RLKLLLKEVSRHIKELEKLLDVSSSQQDLSSW 8624
Score = 145 bits (365), Expect = 6e-34
Identities = 480/2548 (18%), Positives = 978/2548 (38%), Gaps = 316/2548 (12%)
Query: 2 EQFPKETV-VESSGPKVLETAEEIQ---ERRQEVLTRYQSFKERVAERGQKLEDSYH-LQ 56
++F K T + +++ A EI + +Q + + +S KE+V + LE+ ++
Sbjct: 1390 KEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTME 1449
Query: 57 VFKRDADDLGK-------WIMEKVNIL----TDKSYEDPT---------NIQGKYQKHQS 96
+ K D G WI EK L T S D I+ K
Sbjct: 1450 MVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVG 1509
Query: 97 LEAEVQTKSRLMSELEKTR-EERFTMGHSAHEETKAHIEELRHLWDLLLELTLE-KGDQL 154
LE E Q+ ++ ++ E R + + T EE + H + L +L L+ + K ++
Sbjct: 1510 LEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGT--ILGHLSQQQKFEEN 1567
Query: 155 LRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRV 214
LR K QQ V E D L A +++ T + ++ D L + +
Sbjct: 1568 LR--KIQQSVSEFEDKL---------AVPIKICSSATETYKVLQEHMDLCQALESLSSAI 1616
Query: 215 VEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNA-ANLQRFKRDV 273
+ A + + + + +E + A +RQ AL N A+ QR ++++
Sbjct: 1617 TAFSASARKVVNRDS-----CVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKEL 1671
Query: 274 TEAIQWIKEKEPVLTSE--DYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKL- 330
+ + W++ E +S D D V EG + L+ + + +L E L
Sbjct: 1672 SSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLF 1731
Query: 331 TLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDEL----SGWM 386
+++ D ++ E L W + + R LQ+ H+ FDEL S W+
Sbjct: 1732 SVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQ---QFDELLLSFSVWI 1788
Query: 387 NEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADE---------TGQDLV 437
+ + + +V L RH+ H E++S QS +DL
Sbjct: 1789 KLFLSELQTTS-EISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLH 1847
Query: 438 NANHEASDEVR---EKMEILDNNWTALLELWD--ERHRQYEQCLDFHLFYRDSEQVDSWM 492
+A D + E ++++ AL L + + H L R + + + M
Sbjct: 1848 LLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQ---LRQTVEATNSM 1904
Query: 493 SRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSEN 552
++ E+ L +DL ++L +A+AL E+ + I++ + K+ + S
Sbjct: 1905 NKNESDLIEKDLNDALQNAKAL--------ESAAVSLDGILSKAQYHLKIGSSEQRTS-- 1954
Query: 553 IKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDS-DDLKNWINKKKKLADDEDYK 611
+A D L + ++ T++ +L+K ++D ++L I ++ D E K
Sbjct: 1955 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2014
Query: 612 DI--QNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLW 669
+ Q L+ R++ E EL ++ +L ++ +++ + + V ++ + W
Sbjct: 2015 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTW 2074
Query: 670 EELLEATKQ-KGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRK 728
++ + +G + +++N + + LE+ + + K +++ K
Sbjct: 2075 DDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSK 2134
Query: 729 HGLLESAVAARQDQVDILTD----LAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLAT 784
H ++ + +Q +D T L + ++I D ++ ES V ++ + E L
Sbjct: 2135 HETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEE 2194
Query: 785 RKKKLLDLLHLQLICRDTEDE-EAWIQETEPSATSTYLGKDL-IASKKLLNRHRVILENI 842
+L L + T DE E W P D + +++LL ++N
Sbjct: 2195 NMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNK 2254
Query: 843 ASHEPRIQEITERGNKMVE--EGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE---- 896
A R++E+ + N + E + D+ L Q +E + + L+
Sbjct: 2255 AL---RLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTA 2311
Query: 897 ANVQFQQYLADLHEAETWIRE---------------------KEPIVDNTNYGADEEAAG 935
+ Q ++++ D+ T + E KE +N + +E
Sbjct: 2312 QSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLN 2371
Query: 936 ALLKKHEAFLLDLNSFGDSMKALRNQANA----CQQQQAAPVEGVAGEQRVMALYDFQA- 990
+L +K+ + +L S G +M L + A C + QA+ E + + ++ +FQ
Sbjct: 2372 SLCRKYHS--AELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE-KHFSESMQEFQEW 2428
Query: 991 -----RSPREVTMKKGD----------VLTLLSSINKDWWKVEAADHQGIVPAVYV-RRL 1034
+ +E + + GD + +L S++ K++A +G ++ +++
Sbjct: 2429 FLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQI 2488
Query: 1035 AHDEFPMLPQRRREEPGNITQ--RQEQIENQYRSLLDRAEERRRRL---LQRYNEFLLAY 1089
+ + E + Q + +Q S L E++ R+L + E
Sbjct: 2489 VSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTE 2548
Query: 1090 EAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGL 1149
G+ + I EKK E VE+ F +L L +++ L EG
Sbjct: 2549 NLGESKQHIPEKKNEVHKVEM------------FLGELLAARESLDKLSQRGQLLSEEGH 2596
Query: 1150 LTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALS-- 1207
+ ++ +L + +L R+ E+ L S H ++ + + +A+
Sbjct: 2597 GAGQEGRLCSQLLTSHQNLLRMTKEK---LRSCQVALQEHEALEEALQSMWFWVKAIQDR 2653
Query: 1208 AADPGSDLFSVQALQRRHEGFERDLVPLGD---KVTI-LGETAERLSESHPDATEDLQRQ 1263
A S L S L++R + L+ G+ K+ + +G+ + L S+ + +Q Q
Sbjct: 2654 LACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQ 2713
Query: 1264 KMELNEAWEDLQGRTKDRKESLNEA-QKFYLFLSKARDLQNWISSIGGMVSSQELAEDLT 1322
L E W D+ + + +L ++ ++ + L+ W+ S+ + + +
Sbjct: 2714 LETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI--EHPLQPQP 2771
Query: 1323 GIE---ILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDD 1379
G++ +LL+ Q ++ E L S EL + S + + + D
Sbjct: 2772 GLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDI 2831
Query: 1380 LEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDL 1439
+ A EK +K+ + + M+ + W+ + + L S DS A KK +
Sbjct: 2832 MTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS-SATQKKLSKI 2890
Query: 1440 DKAITAQE---GKITDLEHFAESLIADEHYAKEEIA-TRLQRVLDRWKALKAQLIDERTK 1495
+ I ++E +++ +E A + + + E+ T +Q + WK + + ++
Sbjct: 2891 KELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSC 2950
Query: 1496 LGDYANL-----KQFYRDLEELE---EWISEMLPTACDE-SYKDATNIQRKYLKHQTFAH 1546
L + + ++F + +LE E S +L T + + + N + ++
Sbjct: 2951 LENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQ 3010
Query: 1547 EV-DGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNE 1605
E+ D + +L + L E + ++ L + ++ L + + KG + E
Sbjct: 3011 EILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQAS-KGCQNKE 3069
Query: 1606 ASRQQRFNTSIRDFEFWLSEAE-TLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALK 1664
QQRF + RDF+ WL A+ T D ++++ L+K ++ + E+
Sbjct: 3070 QILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQK---IQEFLSESENGQH 3126
Query: 1665 DLNTLAEDLLSSGTFNVDQIVKKK-DNVNKRFLNVQELAAAHHEKLKEAYALFQ------ 1717
LN +LS G + K+K + + +E H L + + +
Sbjct: 3127 KLNM----MLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQM 3182
Query: 1718 --FFQDLDDEESWIE--EKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVL 1773
F + + W+ EK++ SS DL + +K + + E+ +EP + +
Sbjct: 3183 KDFEVSAEPIQDWLSKTEKMVHESSNRL-YDLPAKRREQQKLQSVLEEIHCYEPQLNRLK 3241
Query: 1774 DMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESL-EYLQFMQNAEEEE 1832
+ A++L + A + + R++Q + L L K + +L+ + E+ QF +E +
Sbjct: 3242 EKAQQLWEGQA-ASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ 3300
Query: 1833 AWINEKNALAVRGDCGDT--LAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVL 1890
W+ + + + C T + S +K EAL + E +++ + +GE +L
Sbjct: 3301 DWMTDAIHM-LDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTS 3359
Query: 1891 QEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVV---EAWIADK 1947
E I +++++ + SL A K QLE A ++ D V W+
Sbjct: 3360 PEGIPT--IQQQLQSVKDMWASLLSAGIRCKSQLEG--ALSKWTSYQDGVRQFSGWMDSM 3415
Query: 1948 ETSL-KTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQH---NQS 2003
E +L ++ A+L D T+L K L+ + S+ L E ++K ++ + +
Sbjct: 3416 EANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSS--LLETIEVKGAGMTEHYVTQLEL 3473
Query: 2004 KAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKME 2063
+ ++ERY A+ +R ++ + S +K L E+ A W + +
Sbjct: 3474 QDLQERYRAIQERAKEAVTKS--------------EKLVRLHQEYQRDLKAFEVWLGQEQ 3519
Query: 2064 ENLSE--------PVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVP 2115
E L + H +L ++++LQ A QA +L + + G+P
Sbjct: 3520 EKLDQYSVLEGDAHTHETTLRDLQELQ-------VHCAEGQALLNSVLHTREDVIPSGIP 3572
Query: 2116 SSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEAR---QVKNFEMCQEFEQNASTFLQW 2172
+ +E L + W+ + E + + + F+ E+ + A +W
Sbjct: 3573 QAEDR--ALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE-KKW 3629
Query: 2173 ILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIK 2232
E AY ++E G ++ + QLT + AL+L +
Sbjct: 3630 HEEVTAY---RDEVEEVGARAQEILDESHVNSRMGCQATQLT-------SRYQALLLQV- 3678
Query: 2233 YSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLT 2292
L LE++IQ+ + SE +L +S Y T
Sbjct: 3679 -----------------LEQIKFLEEEIQSLE---ESESSLSSYSDWYGS---------T 3709
Query: 2293 HKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSL----EDYTAFLIDKES 2348
HK F++ ++ + V + E L ++ G S E +L + E+
Sbjct: 3710 HKNFKNVATKID-KVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEA 3768
Query: 2349 ENIKSSDEIENAFQALAEGKSYITKEDM 2376
E ++ EI + + L E S + KE M
Sbjct: 3769 ERLRK--EIHDHMEQLKELTSTVRKEHM 3794
Score = 139 bits (350), Expect = 3e-32
Identities = 469/2382 (19%), Positives = 903/2382 (37%), Gaps = 403/2382 (16%)
Query: 8 TVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLG 66
T +S KV+ +QE + +Y+ R ER LE+ H Q +++
Sbjct: 1617 TAFSASARKVVNRDSCVQEAAA-LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFL 1675
Query: 67 KWIMEKVNILTDKSYE---DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGH 123
W+ + + D ++G+ Q Q+L+ EV +++ S+L + +E F++
Sbjct: 1676 TWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS 1735
Query: 124 SAHEET-KAHIEELRHLWDLLLELTLEKGDQLLRAL--KFQQYVQECADILEWIGD--KE 178
+ K H+E+L W L ++ + K L+++ + QQ+ + WI E
Sbjct: 1736 KDDVKMMKLHLEQLDERWRDLPQI-INKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSE 1794
Query: 179 AIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHP-DLPLIQS 237
TS D + HK D E+ +K+G + + + + DL L+Q
Sbjct: 1795 LQTTSEISIMDHQVALTRHK---DHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQG 1851
Query: 238 KQNEVNAAWERLRGLALQRQKALSNAAN----------LQRFKRDVTEAIQWIKEKEPVL 287
K + +E + +RQ ALS+ A + R R EA + + E L
Sbjct: 1852 KAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDL 1911
Query: 288 TSEDYGKDL---------------VASEGLFHSHKGLERNLAVMSDKVKELCAKAEKL-- 330
+D L + S+ +H G +LC + E++
Sbjct: 1912 IEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQN 1971
Query: 331 ---TLSHPSDAPQI-----QEMKEDLVSSWEHIRALATSRYEK---LQATYWYHR-FSSD 378
T +DA + Q+ KE+L+ S E I K QA R F+
Sbjct: 1972 LLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQL 2031
Query: 379 FDELSG------WMNEKTAAIN------ADELPTDVAGGEVLLDRHQQHKHE-------- 418
DEL+ W+ +K I A E+ ++ EV D ++ HE
Sbjct: 2032 EDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGL 2091
Query: 419 IDSYDDRFQSADETGQDLVNAN---------------------HE-ASDEVREKMEILDN 456
ID + + L NA+ HE A +++ K + LDN
Sbjct: 2092 IDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDN 2151
Query: 457 NWTALLELWDERHRQYEQCLDFHLFYRDSEQ-VDSWMSRQEAFLENED-LGNSLGSAEAL 514
+ L E + + DF L D E VD W+ E EN D L SL + +
Sbjct: 2152 FTSKGKHLLSELKKIHSS--DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDV 2209
Query: 515 LQKHEDFE----EAFTAQEEKIITVDK--TATKLIGDDHYDSENIKAIRDGLLARRDALR 568
L ++ E E I +D A +L+ + + +N KA+R + L
Sbjct: 2210 LSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKN-KALR------LEELH 2262
Query: 569 EKAATRRRLLK-----------ESLLLQKLYEDSD--DLKNWINKKKKLADDEDYKDIQN 615
K + L K E+ L+QKL + ++ K + K I +
Sbjct: 2263 SKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFIND 2322
Query: 616 LKSRVQKQQVFEKELAVNKT-----QLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWE 670
+ + K + A N+T ++++IQK Q +N+ + + S
Sbjct: 2323 ITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL 2382
Query: 671 ELLEATKQKGTQLHEANQQLQFENNA---EDLQRWLEDV-----EWQVTSEDYGKGLAEV 722
E L + HEA QL + A E L++ + EW + ++ K E
Sbjct: 2383 ESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK---ES 2439
Query: 723 QNRLRKHGLLESAVAARQDQVDILTDLAAYFEEI--------GHPDSKDIRARQESLVCR 774
+R +LE+ + Q+ +D ++D + + + H + + + QE +
Sbjct: 2440 SDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQIT-- 2497
Query: 775 FEALKEPLATRKKKLLDLLHLQLICRDT---EDEEA----WIQETEPSATSTYLGKD--- 824
+A +E A K+ L D LQ + ED+ WI E E + LG+
Sbjct: 2498 -KANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQH 2556
Query: 825 LIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAED--VASRVKSLNQNME 882
+ K +++ + L + + + ++++RG + EEGH A ++ + S++ + +QN+
Sbjct: 2557 IPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLL 2616
Query: 883 SLRARAARR-QNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGAD------EEAAG 935
+ R Q L+ + ++ L + I+++ ++T D +
Sbjct: 2617 RMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQD 2676
Query: 936 ALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPRE 995
LL K E + + G +ALR+ Q+ +E + + A+S E
Sbjct: 2677 ILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLE 2736
Query: 996 VTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQ----------- 1044
+ + + + + W +E+ D Q I + + ++F +L
Sbjct: 2737 SVISQWNDYVERKNQLEQW--MESVD-QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDH 2793
Query: 1045 ---------------RRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAY 1089
+ E+ QE+++ Q+ ++ A+E+ R++ + + L+
Sbjct: 2794 TRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYL 2853
Query: 1090 EA-GDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEG 1148
+A + +W+ K E ++ + D + + +L I ++ D
Sbjct: 2854 DAVHEFTDWLHSAKEE------------LHRWSDMSGDSSATQKKLSKIKELIDS----- 2896
Query: 1149 LLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREAD----DTKEQIEKKCQ 1204
R+ SR ++ LA E +Q +A E+ H E D K+ + Q
Sbjct: 2897 ---------REIGASRLSRVESLAPEVKQNT-TASGCELMHTEMQALRADWKQWEDSVFQ 2946
Query: 1205 ALSAADPGSDLFSVQAL-QRRHEGFERDLVPLGDKVTILGET-AERLSESHPDATED--- 1259
S + +L S AL ++ G L ++ + L +T A++L+ T++
Sbjct: 2947 TQSCLE---NLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIV 3003
Query: 1260 -LQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSS---- 1314
+ E+ +A + + RT+D K LNE +F +RDL + + G++
Sbjct: 3004 ECWHKGQEILDALQKAEPRTEDLKSQLNELCRF------SRDLSTYSGKVSGLIKEYNCL 3057
Query: 1315 -----------------------QELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDF 1351
++ + L +I + + ++ + + Q +++F
Sbjct: 3058 CLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEF 3117
Query: 1352 SAELIDSGHHASPEIEK------------------KLQAVKLERDDLEKAWEKRKKILDQ 1393
+E + H + + K K+ A K + + +++ L+
Sbjct: 3118 LSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALEN 3177
Query: 1394 CLELQM--FQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKA---ITAQEG 1448
L++QM F+ + + ++ W+ E + + + L L A +++ L I E
Sbjct: 3178 -LKIQMKDFEVSAEPIQDWLSKTEKMVH-ESSNRLYDLPAKRREQQKLQSVLEEIHCYEP 3235
Query: 1449 KITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGD--YANLKQFY 1506
++ L+ A+ L + A + R+ ++ ++ AL + L E+ D A QF
Sbjct: 3236 QLNRLKEKAQQLWEGQA-ASKSFRHRVSQLSSQYLAL-SNLTKEKVSRLDRIVAEHNQFS 3293
Query: 1507 RDLEELEEWISE---MLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGN 1563
++EL++W+++ ML + C + D + + + LK + + Q+ ++ G
Sbjct: 3294 LGIKELQDWMTDAIHMLDSYCHPT-SDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGE 3352
Query: 1564 SLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEA-SRQQRFNTSIRDFEFW 1622
S+++ ++ +G +++QL+ +K+ W LL +L A S+ + +R F W
Sbjct: 3353 SVLQNTSPEGIP-TIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGW 3411
Query: 1623 LSEAETLLAMKD-QARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNV 1681
+ E L + Q +L +L K +LL E+L+ ++L E + G
Sbjct: 3412 MDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLS-------YSSLLETIEVKGAGMT 3464
Query: 1682 DQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDY 1741
+ V + + ++QE A E+ KEA EKL+R+ Q+Y
Sbjct: 3465 EHYVTQLE-----LQDLQERYRAIQERAKEAVTK--------------SEKLVRLH-QEY 3504
Query: 1742 GRDLQGV-------QNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRL 1794
RDL+ Q L ++ LEG+ HE ++++ ++L+ A GQ L
Sbjct: 3505 QRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDL----QELQVHCAEGQA-----L 3555
Query: 1795 AQFVEHWEK---LKELAKARGLKLEESLEYLQFMQNAEEEEAW-----INEKNALAVRGD 1846
V H + + +A LE + Q Q+ E +N+ + +
Sbjct: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
Query: 1847 CGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEES---QNKEISSKI 1903
D T HE + + V+ V A+ ++IL++ Q +++S+
Sbjct: 3616 QVDEWLKTAEEKKWHE----EVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRY 3671
Query: 1904 EALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDF 1963
+AL L + + K E+ + +E W + K D D
Sbjct: 3672 QAL------LLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDT 3725
Query: 1964 LTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAI---EERYAALLKR---- 2016
+ + K TL+ L+ ++ L SA+ +A+ EE A L++
Sbjct: 3726 VMMGKKLKTLEVLLKDMEKGH--------SLLKSAREKGERAVKYLEEGEAERLRKEIHD 3777
Query: 2017 -WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVH---- 2071
EQL E ++ R++ + L+K L EF+ K AL W + +E L P
Sbjct: 3778 HMEQLKELTSTVRKE----HMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKME 3833
Query: 2072 ----CVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQI 2109
L++ + LQ+ S+ + + LLEL Q +
Sbjct: 3834 LYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDV 3875
Score = 134 bits (337), Expect = 1e-30
Identities = 446/2355 (18%), Positives = 873/2355 (37%), Gaps = 348/2355 (14%)
Query: 2 EQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRD 61
E P E + S VL AE + R + + Q +E++ ++ ++ LQ ++ +
Sbjct: 5963 EADPAEQLALQSTLTVL--AERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCE 6020
Query: 62 ADDLGKWIME-KVNILTDKS-YEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERF 119
AD+L W++ K + T S ++P +++ + Q++ E++ K +SEL E
Sbjct: 6021 ADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL 6080
Query: 120 TMGHS-AHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQE---------CAD 169
G + +E + +LR L LLEL D+ L Q +E
Sbjct: 6081 LEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPG 6140
Query: 170 ILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQ-VELVAKEGRVVEVNQYANECAEE- 227
+ EW+ T ++ E+ + E + VA G + + A E + +
Sbjct: 6141 VQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 6200
Query: 228 -NHPDLPLIQ---------SKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAI 277
PD+ L Q S ++++ WE L +QK L N
Sbjct: 6201 GEKPDV-LSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLE------------ 6247
Query: 278 QWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSD 337
+E+E VL S L++ L+ + AV S
Sbjct: 6248 ---QEQEQVLYSRP--NRLLSGVPLYKGDVPTQDKSAVTS-------------------- 6282
Query: 338 APQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNE------KTA 391
+ + L ++E + + S K Q+ + + S W+++
Sbjct: 6283 ------LLDGLNQAFEEVS--SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6334
Query: 392 AINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKM 451
A+ +E T + E+L ++ E+D + F A N + D + + +
Sbjct: 6335 ALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQA-------FPENGDNRDVIEDTL 6387
Query: 452 EILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSA 511
L + L + ++R Q ++ L L +++ +V ++ + L N
Sbjct: 6388 GCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQP 6447
Query: 512 EA----LLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDAL 567
A +Q+ ED + F A II + + KL + E K L D L
Sbjct: 6448 VAEQIEAIQQAEDGLKEFDA---GIIELKRRGDKLQVEQPSMQELSK-----LQDMYDEL 6499
Query: 568 REKAATRRRLLKESLLLQKLYEDS-DDLKNWINK-KKKLADDE-----DYKDIQNLKSRV 620
+RR L ++L L+ YE + DL + + ++K+A D+ ++IQ L +
Sbjct: 6500 MMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKH 6559
Query: 621 QKQ-QVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQK 679
++ Q E + + +T I +A T +E+ + +L+ ++
Sbjct: 6560 KEYFQGLESHMILTETLFRKIIS----------FAVQKETQFHTELMAQASAVLKRAHKR 6609
Query: 680 GTQL-HEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAE-----VQNRLRKHGLLE 733
G +L + + + ++L R LE VE + S GL E + +R+ + L+
Sbjct: 6610 GVELEYILETWSHLDEDQQELSRQLEVVESSIPS----VGLVEENEDRLIDRITLYQHLK 6665
Query: 734 SAVAARQDQV-DIL------------TDLAAYFEEIGHPDSKDIRARQESLVCRFEALKE 780
S++ Q ++ +L +DL + ++G + + L R E + +
Sbjct: 6666 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKEL-HRLETILK 6724
Query: 781 PLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILE 840
+ + DL+H +D E W Q+ S + ++L + LN +
Sbjct: 6725 HWTRYQSESADLIHWLQSAKDR--LEFWTQQ------SVTVPQELEMVRDHLNAFLEFSK 6776
Query: 841 NIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQ 900
+ + + GN+++ + S + ++ L Q L +Q
Sbjct: 6777 EVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLH-QLQ 6835
Query: 901 FQQYLA--DLHEAETWIREKEPIV----DNTNYGADEEAAGALLKKHEAFLLDLNSFGDS 954
+ + + E +WI E ++ DN +A L+K++ F +D+N
Sbjct: 6836 MDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDIN----- 6890
Query: 955 MKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDW 1014
C+Q V Q V+ + S R K D L ++NK W
Sbjct: 6891 ----------CKQLTVDFV-----NQSVLQISSQDVESKRS---DKTDFAEQLGAMNKSW 6932
Query: 1015 WKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEER 1074
+ QG+V ++ +L + + + EN + L E +
Sbjct: 6933 QIL-----QGLVT---------EKIQLLE--------GLLESWSEYENNVQCLKTWFETQ 6970
Query: 1075 RRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTN---- 1130
+RL Q+ + GD + +N + D+ +L K ++ + + N
Sbjct: 6971 EKRLKQQ-------HRIGD------QASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL 7017
Query: 1131 -EPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSA------- 1182
+ + D++ + L +EL W +L + + + LL S
Sbjct: 7018 IQNKKEDVSSIVMSTL-------------RELGQTWANLDHMVGQLKILLKSVLDQWSSH 7064
Query: 1183 ----HAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDK 1238
+ + EA + + +L A D ++Q LQ E ER L G
Sbjct: 7065 KVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD--NLQNLQDDLEKQERSLQKFG-- 7120
Query: 1239 VTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKA 1298
T + L E HP TE L E+N W +L ++ E L ++ +
Sbjct: 7121 ----SITNQLLKECHPPVTETLTNTLKEVNMRWNNL---LEEIAEQLQSSKALLQLWQRY 7173
Query: 1299 RDLQNWISSIGGMVS--SQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELI 1356
+D +S + EL + T +I + D ++D L
Sbjct: 7174 KDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLH 7233
Query: 1357 DSGHHASPEIE----KKLQAVKLERDD----LEKAWEKRKKILDQ-CLELQMFQGNCDQV 1407
+ G +++ +Q+ +L LE+A K++ L L+ + F + + +
Sbjct: 7234 ELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEAL 7293
Query: 1408 ESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYA 1467
E+W+V E L+ D S L + ++ ++L + DL+ E +
Sbjct: 7294 EAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE--LGYRLPL 7351
Query: 1468 KEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDES 1527
++ R+Q + W + +Q + +KL + L Q LE+ E W+ ++ T +
Sbjct: 7352 NDKEIKRMQNLNRHWSLISSQTTERFSKLQSF--LLQHQTFLEKCETWMEFLVQTEQKLA 7409
Query: 1528 YKDATNIQ---RKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQ 1584
+ + N Q + H+ F E+ R + +H +I G L+E D +E +L
Sbjct: 7410 VEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE-FNLKLTL 7468
Query: 1585 LKEHWDHLLERTNDKGKKLNEASRQ-QRFNTSIRDFEFWLSEAETL--LAMKDQARDLAS 1641
L W ++ R + ++ RQ QR+ WL E L + L
Sbjct: 7469 LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ 7528
Query: 1642 AGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQEL 1701
A L + Q E+ L ++ + + LL S + ++ + +QE
Sbjct: 7529 ARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAE------LAEIQEK 7582
Query: 1702 AAAHHEKLKEAYALFQF-FQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEG 1760
+ +L+E F +D + E I + L ++ + + + L Q+L H+ L
Sbjct: 7583 WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKL--RTFKKKLS--QSLPDHHEELHA 7638
Query: 1761 ELVAHEPAIQNV------LDMAEKLKD--KAAVGQEEIQL---RLAQFVEHWEKLKELAK 1809
E + + V L LKD A + ++I + R+ WE+L
Sbjct: 7639 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7698
Query: 1810 ARGLKLEESL-EYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDF 1868
R ++ E L E+ F + +E W+ + + + GD L +K + E
Sbjct: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN--GDILIEEMIEKLKKDYQEEIA 7756
Query: 1869 AVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDD- 1927
E ++Q + GE + ES+ EI K+ +N++ L IAA +L++
Sbjct: 7757 IAQENKIQ-LQQMGERLAK--ASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETL 7813
Query: 1928 YAFQEFNWKADVVEAWIADKETSLKTN--GNGADLGDFLTLLAKQDTLDASLQSFQQERL 1985
A Q+ + + W+A E+ L + + + L +Q L ++ +
Sbjct: 7814 VAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEK-HSTGV 7872
Query: 1986 PEITDLKDKLI-----SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQK 2040
+ +L + L+ A + +I++ L +RW + S +E++L +++
Sbjct: 7873 ASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMS-------MERRLKIEE 7925
Query: 2041 AEDLFVEFAHKASALNNWCEKMEENLSEP-----VHCVSLNEIRQLQKDHEDFLASLARA 2095
L+ +F S +W + E + P ++ V+ E+++ + A
Sbjct: 7926 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFE----------AFQ 7975
Query: 2096 QADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQ---ELQKEEA-- 2150
+ +CL +L+ + + Y L E + L ++ E Q LQK
Sbjct: 7976 RQVHECLTQLE-------LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSI 8028
Query: 2151 -RQVKNF-EMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQA 2208
R++K+F +EFE + L W+ E + E ++++++ K Q+EI
Sbjct: 8029 LRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC-DVQAKIKQLKAFQQEISL 8087
Query: 2209 MKRQLTKIVDLGDNL 2223
++ +I+ G+ L
Sbjct: 8088 NHNKIEQIIAQGEQL 8102
Score = 124 bits (310), Expect = 1e-27
Identities = 463/2512 (18%), Positives = 946/2512 (37%), Gaps = 322/2512 (12%)
Query: 18 LETAEEIQERRQEVLTRYQSFKERVAERGQ-KLEDSYHLQVFKRDADDLGKWIMEKVNIL 76
L+ E ++E+ + R+ ++ + + Q + + L V + +L +W E+ +
Sbjct: 4237 LDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNI 4296
Query: 77 TD--KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFT-MGHSAHEETKAHI 133
+ K P Q H ++ +E++ K L+ L K + +G + + + +
Sbjct: 4297 AEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKAL 4356
Query: 134 EELRHLWDLLLELTLEKGDQLLRAL----KFQQYVQECADILEWIGDKEAIATSVELGED 189
+ + + L +L ++ L +AL +F V + ++ K + L D
Sbjct: 4357 SDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPD 4416
Query: 190 WERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEE-NHPDLPLIQSKQNEVNAAWER 248
+V K + Q L + V + E +E + + K E+ + ++
Sbjct: 4417 DVSKQV--KTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDS 4474
Query: 249 -LRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHK 307
L+ + + Q+ N + + FK D +A W+K+ + V E +L+ H+
Sbjct: 4475 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEI---NLMNESSELHTQL 4531
Query: 308 GLERNLAVMSDKVKELCAKAEK-----LTLSHPSDAPQIQEMKEDLVSSWEHIRALATSR 362
+N+ S + + L ++ L + D + E L + I ALA +
Sbjct: 4532 AKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDK 4591
Query: 363 YEKLQATYWYHRFSSDFDELSGWMNEKTAA--INADELPTDVA---------GGEVLLDR 411
+ K+Q + + EL+ + A + ++PTD+A G +LD
Sbjct: 4592 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDE 4651
Query: 412 HQQHKHEIDSYDDRFQSADETGQD--------LVNANHEASDEVREKMEILDNNWTALLE 463
+D + + + TGQ LV H + +++ +L++ +A E
Sbjct: 4652 VAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQE 4711
Query: 464 LWDERHRQYEQCLDFHLFYRDSEQV---DSWMSRQEAFLENEDLGNSLGSAEALLQKHED 520
H + Q L+ L EQ + + +E L SL + +L++
Sbjct: 4712 -----HEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTI 4766
Query: 521 FEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKE 580
E + + +K I++ + L A+ E + +
Sbjct: 4767 HLEDLAPHLDPL-AYEKAR-----------HQIQSWQGELKLLTSAIGETVTECESRMVQ 4814
Query: 581 SLLLQKLYEDSDDLKNWINKKKKLADDEDYKDI--QNLKSRVQKQQVFEKELAVNKTQLE 638
S+ Q S D W+ + K Y D+ Q+++ ++K Q+ ++E+ + +
Sbjct: 4815 SIDFQTEMSRSLD---WLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMN 4871
Query: 639 NIQ-KTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FENNA 696
+ K ++ + S ++ L+E++ L ++ EA + + L E Q Q +
Sbjct: 4872 ALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVF 4931
Query: 697 EDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEI 756
+ WLED + + G + + L+ H S ++ L L A + +
Sbjct: 4932 QAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPL 4991
Query: 757 GHPDSK-DIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEA--WIQETE 813
P K D+ + SL R + + + LL Q EE + +TE
Sbjct: 4992 IKPTGKEDLEQKVASLELRSQRMSRDSGAQVD-LLQRCTAQWHDYQKAREEVIELMNDTE 5050
Query: 814 PSATSTYLGKDLIA--SKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVA 871
+ L K + +++ L+ H+ ++ + S +I + E+ +++ + G+ A++
Sbjct: 5051 KKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATL 5110
Query: 872 SR-VKSLNQNMESLRARAARRQNDLEANVQ----FQQYLADLHEAETWIREKEPIVDNTN 926
SR + ++ Q LRA A ++ LE V F + E +++K P
Sbjct: 5111 SRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLP------ 5164
Query: 927 YGADEEAAG-----ALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEG------ 975
G+ E A LL+ H+ F+L+L ++ LR Q + Q AAP G
Sbjct: 5165 -GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLM 5223
Query: 976 ---VAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINK-DWWKVEAADHQGIVPAVYV 1031
A + R + + + + + V + D + + IN W E ++ G
Sbjct: 5224 QEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEID 5283
Query: 1032 RRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLD-RAEERRRRLLQRYNEFLLAYE 1090
+L +E +L NI + E+ + +Y L E +L + + + +
Sbjct: 5284 AQL--EELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQ 5341
Query: 1091 AGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLR-DINKVADDLLFEGL 1149
D ++ +++ KA + EL ++ + KDL T +L+ + V + +
Sbjct: 5342 IQDKIKEVEQSKATSQ--------ELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5393
Query: 1150 LTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHA------VEVFHREADDTKEQIEKKC 1203
L E +L ++Q+ ++ Q LG A E+ + + ++ K
Sbjct: 5394 LGEELDGCNSKLMELDAAVQKFLEQNGQ-LGKPLAKKIGKLTELHQQTIRQAENRLSKLN 5452
Query: 1204 QALSAADPGSDLFSV-------------------QALQRR-----HEGFERDLVPLGDKV 1239
QA S + +++ + A Q R H+ + + ++
Sbjct: 5453 QAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSEL 5512
Query: 1240 TILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQK-FYLFLSKA 1298
+ E + L+ + TE + +Q EL E+L+ K R ++L +A K F ++
Sbjct: 5513 EAMTEKLQYLTSVY--CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAEL 5570
Query: 1299 RDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDS 1358
+ LQ + ++S E+ ++ L Q ++ME+ P QA+ +L S
Sbjct: 5571 KKLQAALEQAQATLTSPEVGR--LSLKEQLSHRQHLLSEMESLKPKVQAV-----QLCQS 5623
Query: 1359 GHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSL 1418
++ L E+A + + QC +Q +Q E M + +
Sbjct: 5624 ALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLI 5683
Query: 1419 RS-----DDK----SSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESL-IADEHYAK 1468
+DK S++ L+A + + ++L + I + +I L + L + +H
Sbjct: 5684 EGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATM 5743
Query: 1469 EEIATRLQRVLDRWKALKAQLIDERT--------KLGDYANLKQFYRDLEELEEWISEM- 1519
T ++ + + + L +L+ + G L + E SE+
Sbjct: 5744 LLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEIS 5803
Query: 1520 LPTACDE----SYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNE 1575
P AC + DA+ Q A + + ++H + E G E
Sbjct: 5804 SPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYE----PGLE 5859
Query: 1576 EAMKEQLEQLKEHWDHLLERTNDKGKKLNEA-SRQQRFNTSIRDFEFWLSEAETLLAMKD 1634
+ +L L+ W+ L ++K + L EA RQQ++ S++ + E L + +
Sbjct: 5860 PSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIE--LKLSE 5917
Query: 1635 QARDLASAGNLLKKHQLLEREMLAREDALKDL-NTLAEDLLSSG---------------T 1678
S + + +HQ L E+L +D + +L ++LAE+L+S T
Sbjct: 5918 SPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLT 5977
Query: 1679 FNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESW---------- 1728
+++ + + + ++E E+ ++ AL ++ + D+ +SW
Sbjct: 5978 VLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDT 6037
Query: 1729 ------------------------IEEKLIRVSSQDYGRD---LQG-------VQNLLKK 1754
IE+K++ +S + L+G + L K
Sbjct: 6038 ALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK 6097
Query: 1755 HKRLEGELVAHEPAIQN--------VLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKE 1806
+RL+G L+ + A+ + + E D A +Q LAQ W + ++
Sbjct: 6098 LRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQ 6157
Query: 1807 LAKARGLKLEESL-EYLQFMQN-AEEEEAWINEKNALAVRGDC--------------GDT 1850
+ + +LE+ L E +++ A E + + +A GD G+
Sbjct: 6158 SSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEK 6217
Query: 1851 LAATQSLLMKHEALENDFAVHETRVQNVCAQGEDIL-----NKVL--------QEESQNK 1897
+A + MK E+L +F+ + +QNV Q ++ + N++L +Q+K
Sbjct: 6218 SSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDK 6277
Query: 1898 E-ISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGN 1956
++S ++ LN+ ++ K Q + Q+ W+ D E L
Sbjct: 6278 SAVTSLLDGLNQAFEEVSSQSGGAKRQ--SIHLEQKLYDGVSATSTWLDDVEERLFV-AT 6334
Query: 1957 GADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKR 2016
+ T L Q+ L ++ +E + + +L + + IE+ LL R
Sbjct: 6335 ALLPEETETCLFNQEILAKDIKEMSEE-MDKNKNLFSQAFPENGDNRDVIEDTLGCLLGR 6393
Query: 2017 WEQLLEASAVHRQKLLEKQLP--LQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVS 2074
LL++ R ++++L L DL V F A +K+ +PV
Sbjct: 6394 L-SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQ 6451
Query: 2075 LNEIRQLQKDHEDFLASLA-------RAQADFKCLLEL-------DQQIKALGVPSSPYT 2120
+ I+Q + ++F A + + Q + + EL D+ + +G S
Sbjct: 6452 IEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLN 6511
Query: 2121 W-LTVE-VLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRA 2178
LT++ ER + L+D++E ++++ ++ V + E Q+ + Q LE+
Sbjct: 6512 QNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQG-LESH- 6569
Query: 2179 YFLDGSLLKETGTLESQLEANKRKQKEIQA---MKRQLTKIVDLGDNLEDALILDIKYST 2235
L +L ++ + Q E + QA +KR + V+L LE LD
Sbjct: 6570 MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQE 6629
Query: 2236 IGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENL 2287
+ R +E I + + +E+ L + T+Y+H +L
Sbjct: 6630 LS-------------RQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSL 6668
Score = 121 bits (304), Expect = 7e-27
Identities = 247/1260 (19%), Positives = 512/1260 (40%), Gaps = 157/1260 (12%)
Query: 1090 EAGDMLEWIQEKK---------AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKV 1140
E+ D++ W+Q K + EL+ V + F EF K+++ +
Sbjct: 6732 ESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 6791
Query: 1141 ADDLLFEGLLTPEGAQIRQELN---SRWGSL--------QRLADEQRQLLGSAHAVE--- 1186
+ LL L + A +R EL+ S+W L ++L Q L S HA+
Sbjct: 6792 GNQLL--RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVM 6849
Query: 1187 --------VFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDK 1238
V ++ D+ K I K ++ ++++GF+ D+
Sbjct: 6850 SWISLMENVIQKDEDNIKNSIGYK--------------AIHEYLQKYKGFKIDINCKQLT 6895
Query: 1239 VTILGETAERLS----ESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNE-AQKFYL 1293
V + ++ ++S ES D Q +N++W+ LQG ++ + L + +
Sbjct: 6896 VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSE 6955
Query: 1294 FLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSA 1353
+ + + L+ W + + Q D ++ L+ Q+ ++A+ + +E
Sbjct: 6956 YENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGL 7015
Query: 1354 ELI-DSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCL-ELQMFQGNCDQVESWM 1411
LI + S + L+ + +L+ + K +L L + + D++ S++
Sbjct: 7016 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYL 7075
Query: 1412 VARENSLRSDDKSSLDSLEALMKKRDDLDKA---ITAQEGKITDLEHFAESLIADEH-YA 1467
+ SL S + SLEA+ + D+L + QE + L+ + H
Sbjct: 7076 MEARYSL-SRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPV 7134
Query: 1468 KEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDES 1527
E + L+ V RW L ++ ++ L Q Y+D + + +E
Sbjct: 7135 TETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL 7194
Query: 1528 YKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKE 1587
K ATN K + A + ++ + G+ + +SL + E EQLK+
Sbjct: 7195 LKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLF----------FLHELGEQLKQ 7241
Query: 1588 HWD----------------HL--LERTNDKGKKLNEAS--RQQRFNTSIRDFEFWLSEAE 1627
D HL LE+ K + +A + F S+ E W+ EAE
Sbjct: 7242 QVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE 7301
Query: 1628 TLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKK 1687
+L +D + + + ++ + L+ +ML DL+ L E L D+ +K+
Sbjct: 7302 EILQGQDPSHS-SDLSTIQERMEELKGQMLKFSSMAPDLDRLNE--LGYRLPLNDKEIKR 7358
Query: 1688 KDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQG 1747
N+N+ + + KL+ Q F L+ E+W+E + + Q ++ G
Sbjct: 7359 MQNLNRHWSLISSQTTERFSKLQSFLLQHQTF--LEKCETWME--FLVQTEQKLAVEISG 7414
Query: 1748 -VQNLLKK---HKRLEGELVAHEPAIQNVLDMAEKLKDKAAV-GQEEIQLRLAQFVEHWE 1802
Q+LL++ H+ + E+ + + + +++ ++L ++ V ++E L+L W+
Sbjct: 7415 NYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQ 7474
Query: 1803 -KLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVR--GDCGDTLAATQSLLM 1859
++ + RG+ + ++ ++ + AE+ W+ E + L + G L ++L
Sbjct: 7475 GVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFD 7534
Query: 1860 KHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAA 1919
+ + E F + G+ +L + + + +++ + EK S + +
Sbjct: 7535 EVQFKEKVFLRQQGSYILTVEAGKQLL--LSADSGAEAALQAELAEIQEKWKSASMRLEE 7592
Query: 1920 WKLQLEDDYAFQEFNWKADVVEAWIADKETSLKT--NGNGADLGDFLTLLAKQD----TL 1973
K +L AF +W + E IAD L+T L D L + L
Sbjct: 7593 QKKKL----AFLLKDW--EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKEL 7646
Query: 1974 DASLQSFQQERLPEITDLKDKL---ISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQK 2030
+ ++ S+ + L +++ LKD L ISA + + ER L ++WE+L ++ RQ+
Sbjct: 7647 ENAVGSWTDD-LTQLSLLKDTLSAYISA--DDISILNERVELLQRQWEELCHQLSLRRQQ 7703
Query: 2031 LLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLA 2090
+ E+ + + F+ K L W +ME +S+ + I +L+KD+++
Sbjct: 7704 IGERL-------NEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQE--- 7753
Query: 2091 SLARAQADFKCLLELDQQIKALGVPS--SPYTWLTVEVLERTWKHLSDIIEEREQELQKE 2148
+A AQ + L ++ +++ S S + +V +R W+HL D+I R ++L+
Sbjct: 7754 EIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDR-WQHLLDLIAARVKKLK-- 7810
Query: 2149 EARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRK--QKEI 2206
+ Q+ ++N S+ W+ + + + E Q + N+++ Q++I
Sbjct: 7811 -----ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 7865
Query: 2207 QAMKRQLTKIVDLGDNL--------EDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQ 2258
+ + +++L + L DA I+ +T L ++W + + + + +E+
Sbjct: 7866 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7925
Score = 117 bits (293), Expect = 1e-25
Identities = 446/2409 (18%), Positives = 916/2409 (38%), Gaps = 370/2409 (15%)
Query: 30 EVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQG 89
+++ YQ+ K V++ + + +D +DL KW K +K
Sbjct: 2093 DLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDL-KWAFSKHETAKNKMN-------- 2143
Query: 90 KYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLE 149
K + L+ L+SEL+K F++ K +E W + E E
Sbjct: 2144 --YKQKDLDNFTSKGKHLLSELKKIHSSDFSL-------VKTDMESTVDKWLDVSEKLEE 2194
Query: 150 KGDQLLRALKFQQYVQECADILE-WIGD-KEAIATSVELGEDWERTEVLHKKFEDFQVEL 207
D+L +L V D +E W + +A ++ ++ R E L K+FE E+
Sbjct: 2195 NMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFES---EV 2251
Query: 208 VAKEGRVVEVNQYANECAE-----ENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALS- 261
K R+ E++ N+ E E PDL I++ + + + +A K +
Sbjct: 2252 KNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTA 2311
Query: 262 NAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVK 321
+ +++F D+T ++E + + L + + + + N++ + +
Sbjct: 2312 QSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLN 2371
Query: 322 ELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDE 381
LC K H ++ + L+ E + L + LQ + H FS E
Sbjct: 2372 SLCRKY------HSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKH-FSESMQE 2424
Query: 382 LSGW-MNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDL-VNA 439
W + K AA + + D E L Q + + + + GQ L +
Sbjct: 2425 FQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHL 2484
Query: 440 NHEASDEVREKMEILDNNWTALLELWDERHRQYEQCL-DFHLFYRDSEQVDSWMSRQEAF 498
+ + ++E++ + + A L+ + + + C + F +++ W+ E
Sbjct: 2485 SKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER 2544
Query: 499 LENEDLGNS---LGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555
E+LG S + + + K E F A E + + + L + H + +
Sbjct: 2545 FNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRL 2604
Query: 556 IRDGLLARRDALREKAATRRRLLKESLLLQK---LYEDSDDLKNWINK-KKKLADDEDY- 610
L + ++ LR T+ +L + LQ+ L E + W+ + +LA E
Sbjct: 2605 CSQLLTSHQNLLR---MTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTL 2661
Query: 611 --KD-IQNLKSRVQKQQVFEKE------LAVNKTQ--LENIQKTGQEMIEGGHYASDNVT 659
KD ++ S++Q + + E +A+ K + L + K GQ +I+
Sbjct: 2662 GSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQ---------- 2711
Query: 660 TRLSEVASLWEELLEATKQKGTQLHEA-NQQLQFENNAEDLQRWLEDVEWQVTSEDYGKG 718
T+L + +W +++ ++ + L +Q + L++W+E V+ ++ +
Sbjct: 2712 TQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQP 2771
Query: 719 LAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHP--DSKDIRARQESLVCRFE 776
+ + L H L+S ++ +D L L A E+ D QE L +F
Sbjct: 2772 GLKEKFVLLDH--LQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFN 2829
Query: 777 ALKEPLATRKKKLLDLLHLQLICRDTEDEEA-WIQE--------TEPSATSTYLGKDLIA 827
+ + +K+ +++ L+ D E W+ ++ S S+ K L
Sbjct: 2830 DIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSK 2889
Query: 828 SKKLLNRHRV---ILENIASHEPRIQEITERGNKMVEEGHFAA--------EDVASRVKS 876
K+L++ + L + S P +++ T + A ED + +S
Sbjct: 2890 IKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQS 2949
Query: 877 LNQNMESLRARAARRQNDLEANVQ--FQQYLADLHEAETWIRE---------KEPIVDNT 925
+N+ S A + + + A ++ +Q+ A L +TW ++ E IV+
Sbjct: 2950 CLENLVSQMALSEQEFSGQVAQLEQALEQFSALL---KTWAQQLTLLEGKNTDEEIVECW 3006
Query: 926 NYGADEEAAGALLKKHEA-------------FLLDLNSFGDSMKALRNQANACQQQQAAP 972
+ G +E AL K F DL+++ + L + N C QA+
Sbjct: 3007 HKG--QEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYN-CLCLQAS- 3062
Query: 973 VEGVAGEQRVM------ALYDFQAR--SPREVTMKKGDVLTLLSSINKDWWKV-----EA 1019
+G +++++ A DFQ + + T K D+ +S ++ K+ E+
Sbjct: 3063 -KGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSES 3121
Query: 1020 ADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLL 1079
+ Q + + + + ++ + +T +E +N + S L + E L
Sbjct: 3122 ENGQHKLNMMLSKGELLSTL-LTKEKAKGIQAKVTAAKEDWKN-FHSNLHQKESALENLK 3179
Query: 1080 QRYNEFLLAYEAGDMLEWIQ--EKKAENTGVELDDV---WELQKKFDEFQKDLNTNEPRL 1134
+ +F ++ E + +W+ EK + L D+ Q+K ++++ EP+L
Sbjct: 3180 IQMKDFEVSAEP--IQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQL 3237
Query: 1135 RDINKVADDLLFEGLLTPEGAQIR-QELNSRWGSLQRLADEQRQLLGSAHAVEVFHREAD 1193
+ + A L +EG + + R +L+S++ +L L E+ L V ++ +
Sbjct: 3238 NRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLD--RIVAEHNQFSL 3294
Query: 1194 DTKEQIEKKCQALSAAD----PGSD----------LFSVQALQRRHEGFERDLVPLGDKV 1239
KE + A+ D P SD L ++ ++++ E + +V G+ V
Sbjct: 3295 GIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESV 3354
Query: 1240 TILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEA-QKFYLFLSKA 1298
L + P+ +Q+Q + + W L K L A K+ +
Sbjct: 3355 ---------LQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGV 3405
Query: 1299 RDLQNWISSIGGMVSSQELAE-DLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELID 1357
R W+ S+ ++ E +L +L + + ++ + + + +E A + +
Sbjct: 3406 RQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE 3465
Query: 1358 SGHHASPEIEKKLQAVKLERDDLEKAW----EKRKKILDQCLEL----QMFQGNCDQVES 1409
H+ + +LE DL++ + E+ K+ + + +L Q +Q + E
Sbjct: 3466 --HYVT----------QLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEV 3513
Query: 1410 WMVARENSLRSDDKSSLD----SLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEH 1465
W+ + L D S L+ + E ++ +L + + + H E +I
Sbjct: 3514 WLGQEQEKL--DQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGI 3571
Query: 1466 YAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYAN-LKQFYRDLEELEEWISEMLPTAC 1524
E+ A L+ + W+A + +L + RT+ + N L+ + ++++EW L TA
Sbjct: 3572 PQAEDRA--LESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEW----LKTAE 3625
Query: 1525 DESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQ 1584
++ + + R ++ EV R++++ ++ NS + C A Q
Sbjct: 3626 EKKWHEEVTAYRDEVE------EVGARAQEILDESHV-NSRMGCQAT------------Q 3666
Query: 1585 LKEHWDHLLERTNDKGKKLNEASRQ-QRFNTSIRDFEFWLSEAETL---LAMKDQARDLA 1640
L + LL + ++ K L E + + +S+ + W +A K D
Sbjct: 3667 LTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3726
Query: 1641 SAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQE 1700
G LK ++L ++M LK E + + + + ++ ++E
Sbjct: 3727 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKY--LEEGEAERLRKEIHDHMEQLKE 3784
Query: 1701 LAAA---HHEKLKEAYALFQFFQDLDDE-ESWIEE--KLIRVSSQDYGRDLQGVQNLLKK 1754
L + H L++ L + F D WI E +++ V + +L + L K
Sbjct: 3785 LTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPK-MELYEKKAQLSK 3843
Query: 1755 HKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLK 1814
+K L+ +++HEP++++V + E L + V ++ ++ Q ++ L + KA +
Sbjct: 3844 YKSLQQTVLSHEPSVKSVREKGEALLE--LVQDVTLKDKIDQLQSDYQDLCSIGKAMMEE 3901
Query: 1815 L---EESLEYLQFM------QNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALE 1865
+ E+ L LQ Q A+ +A + + ++G A + +++LE
Sbjct: 3902 IAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLE 3961
Query: 1866 NDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLE 1925
++ H +R Q+ Q + L+ V + + + P L++A A Q++
Sbjct: 3962 HELQKHVSR-QDTLQQCQAWLSAVQPDLEPSPQ------------PPLSRAEAI--KQVK 4006
Query: 1926 DDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQ-DTLDASLQSFQQER 1984
A QE +L LL D +AS+++ ++
Sbjct: 4007 HFRALQE--------------------------QARTYLDLLCSMCDLSNASVKTTAKDI 4040
Query: 1985 LPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDL 2044
++ KL+ AQ+ L + WE++ + E + LQ A+
Sbjct: 4041 QQTEQTIEQKLVQAQN------------LTQGWEEIKHLKS-------ELWIYLQDADQQ 4081
Query: 2045 FVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLE 2104
+ M+ SE + LN + + +DF+ L QA ++E
Sbjct: 4082 L--------------QNMKRRHSE----LELNIAQNMVSQVKDFVKKLQSKQASVNTIIE 4123
Query: 2105 LDQQIKALGVPSSPYTWLTVEVLERTWKHL----SDIIEEREQELQKEEARQVKNFEMCQ 2160
++ L + L W L +++ +RE++LQ+ +++ C
Sbjct: 4124 ---KVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR-----TRDYHDCM 4175
Query: 2161 EFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLG 2220
++ LE D + + LEA K+ +Q K + + D
Sbjct: 4176 -------NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQK 4228
Query: 2221 DNLEDALILD----IKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEF 2276
+ + L LD +K T L Q+W QL L ++++IQ VS L+E
Sbjct: 4229 QKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL-------IKRKIQ------VSVTNLEEL 4275
Query: 2277 STIYKHFDE 2285
+ + F E
Sbjct: 4276 NVVQSRFQE 4284
Score = 107 bits (266), Expect = 2e-22
Identities = 440/2253 (19%), Positives = 874/2253 (38%), Gaps = 330/2253 (14%)
Query: 54 HLQVFKRDADDLGKWIMEKVNILTDKS--YEDPTNIQGKYQKHQSLEAEVQTKSRLMSEL 111
HL+ + + + KWI EK +L + + + ++ +Y HQ+L ++ + SEL
Sbjct: 5457 HLEEYNEMLELILKWI-EKAKVLAHGTIAWNSASQLREQYILHQTL---LEESKEIDSEL 5512
Query: 112 EKTREE-RFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALK-FQQYVQECAD 169
E E+ ++ E+ + EL + L ++ + L A K +++ E
Sbjct: 5513 EAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKK 5572
Query: 170 ILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENH 229
+ + +A TS E+G + ++ H++ ++E + + + V++ Q A E+
Sbjct: 5573 LQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVV 5632
Query: 230 PDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAA-NLQRFKRDVTEAIQWIK------E 282
LPL + A RL+ A+Q+ + A +++++++ Q I+ E
Sbjct: 5633 ASLPLCHAALRLQEEA-SRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIE 5691
Query: 283 KEPVLTS--EDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLT-LSHPSDAP 339
+PV TS ++ + E L KG + +A ++ K K L KA+ T L ++
Sbjct: 5692 DKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVE 5751
Query: 340 QIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSG--WMNEKTAAINADE 397
+ E EDL E + + + H S E SG N + ++ A
Sbjct: 5752 GLAEGTEDL--DGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR 5809
Query: 398 LPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVRE-------- 449
P+ VA + +++ +I Y +T ++ + AS E E
Sbjct: 5810 SPSPVANTDASVNQ------DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT 5863
Query: 450 -KMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAF-LENEDLGNS 507
K+ L +W L + E+ R + L+ Y+DS Q S ++ EA L+ +
Sbjct: 5864 AKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQ--SISTKMEAIELKLSESPEP 5921
Query: 508 LGSAEALLQKHEDF-EEAFTAQEEKIITVDKTATKLIGD----DHYDSENIKAIRDGLLA 562
S E+ + +H+ +E Q+E A +L+ + D + +++ L
Sbjct: 5922 GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE 5981
Query: 563 RRDALREKAATRRRLLKESL-----------LLQKLYEDSDDLKNWINKKKKLAD----- 606
R +R KA+ +R+LL+E L LQ+ ++D+L +W+ K D
Sbjct: 5982 RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP 6041
Query: 607 -------DEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVT 659
+ D QN+ ++++ V EL+V+ L ++EG + D
Sbjct: 6042 PKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENL---------LLEGKAHTKDEAE 6092
Query: 660 TRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVT-SEDYGKG 718
++ L LLE + LH+ +QL + A++ + DV+ T S +
Sbjct: 6093 QLAGKLRRLKGSLLELQRA----LHD--KQLNMQGTAQEKEE--SDVDLTATQSPGVQEW 6144
Query: 719 LAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEAL 778
LA+ + + ++ Q Q ++ +LA + + + +R E ++ + A
Sbjct: 6145 LAQARTTWT-----QQRQSSLQQQKELEQELAEQKSLL-----RSVASRGEEILIQHSAA 6194
Query: 779 KEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVI 838
+ +K D+L +L E E S+ + + + + + +
Sbjct: 6195 ETSGDAGEKP--DVLSQELG-----------MEGEKSSAEDQMRMKWESLHQEFSTKQKL 6241
Query: 839 LENIASHEPRIQEITERGNKMVE-----EGHFAAED---VASRVKSLNQNMESLRARA-- 888
L+N+ E Q + R N+++ +G +D V S + LNQ E + +++
Sbjct: 6242 LQNVLEQEQE-QVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGG 6300
Query: 889 ARRQNDLEANVQFQQYLAD-LHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLD 947
A+RQ+ + +Q L D + TW+ + E + EE L + E D
Sbjct: 6301 AKRQS-----IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQ-EILAKD 6354
Query: 948 LNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLL 1007
+ + M +N + QA P G R E T+ G +L L
Sbjct: 6355 IKEMSEEMDKNKNLFS-----QAFPENG-------------DNRDVIEDTL--GCLLGRL 6394
Query: 1008 SSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSL 1067
S ++ V + H + +E I Q ++ + SL
Sbjct: 6395 SLLDS-----------------VVNQRCH--------QMKERLQQILNFQNDLKVLFTSL 6429
Query: 1068 LDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELD-DVWELQKKFDEFQKD 1126
D ++L + + + +E IQ+ AE+ E D + EL+++ D+ Q +
Sbjct: 6430 ADNKYIILQKLANVFEQ-----PVAEQIEAIQQ--AEDGLKEFDAGIIELKRRGDKLQVE 6482
Query: 1127 LNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVE 1186
+P +++++K+ D +++ L+ G++ R LN +L + +R L A +E
Sbjct: 6483 ----QPSMQELSKLQD--MYDELMMIIGSR-RSGLNQ---NLTLKSQYERALQDLADLLE 6532
Query: 1187 VFHRE-ADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKV--TILG 1243
+ A D K + K + D + F +G E ++ L + + I+
Sbjct: 6533 TGQEKMAGDQKIIVSSKEEIQQLLDKHKEYF---------QGLESHMI-LTETLFRKIIS 6582
Query: 1244 ETAERLSESHPD----ATEDLQR---QKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLS 1296
++ ++ H + A+ L+R + +EL E +D++E + +
Sbjct: 6583 FAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEV------ 6636
Query: 1297 KARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELI 1356
+++ I S+G + +++ D I L +H + + E + +Q L+D LI
Sbjct: 6637 ----VESSIPSVGLVEENEDRLID----RITLYQHLKSSLN-EYQPKLYQVLDDGKRLLI 6687
Query: 1357 D-SGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARE 1415
S ++ + + + + K + + IL +Q + W+ + +
Sbjct: 6688 SISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR---YQSESADLIHWLQSAK 6744
Query: 1416 NSLRSDDKSSLDSLEALMKKRDDLD------KAITAQEGKITDLEHFAESLIADEHYAKE 1469
+ L + S+ + L RD L+ K + AQ + + L+ +
Sbjct: 6745 DRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTA 6804
Query: 1470 EIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRD-LEELEEWISEMLPTACDESY 1528
+ + L R+ +W L + + KL K R + E+ WIS M
Sbjct: 6805 TLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVI----Q 6860
Query: 1529 KDATNIQR--------KYL-KHQTFAHEVDGRSEQV----HGVINLGNSLIECSACDGNE 1575
KD NI+ +YL K++ F +++ + V V+ + + +E D +
Sbjct: 6861 KDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTD 6920
Query: 1576 EAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQ-QRFNTSIRDFEFWLSEAETLLAMKD 1634
A EQL + + W L +K + L + +++ + W E L +
Sbjct: 6921 FA--EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH 6978
Query: 1635 QARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK-DNVNK 1693
+ D AS N LK Q LE + A+E ++ + L+ + +V IV + +
Sbjct: 6979 RIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQ 7038
Query: 1694 RFLNVQELAAAHHEKLKEAYALFQFFQ-DLDDEESWIEEKLIRVSS-QDYGRDLQGVQNL 1751
+ N+ + LK + + D S++ E +S + L+ VQ
Sbjct: 7039 TWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQ 7098
Query: 1752 LKKHKRLEGELVAHEPAIQNVLDMAEK-LKDKAAVGQEEIQLRLAQFVEHWEK-LKELAK 1809
+ + L+ +L E ++Q + + LK+ E + L + W L+E+A+
Sbjct: 7099 VDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAE 7158
Query: 1810 ARGLKLEESLEYLQFMQ-----------NAEEEEAWINEKNALAVRGDCGDTLAATQ--- 1855
+L+ S LQ Q +++E NE A D D AT
Sbjct: 7159 ----QLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQD 7214
Query: 1856 -SLLMKHEALEND--FAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPS 1912
+ L+K D F +HE GE + +V + S I S +L++ +
Sbjct: 7215 CNDLLKGLGTVKDSLFFLHEL--------GEQLKQQV--DASAASAIQSDQLSLSQHLCA 7264
Query: 1913 LAKAIAAWKLQLEDDYA-FQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQD 1971
L +A+ + L+ ++ F + +EAWI + E L+ + + D T+ + +
Sbjct: 7265 LEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQ-GQDPSHSSDLSTIQERME 7323
Query: 1972 TLDASLQSFQQ-----ERLPEI---TDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEA 2023
L + F +RL E+ L DK I N + R+ +L+ Q E
Sbjct: 7324 ELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLN-----RHWSLIS--SQTTER 7376
Query: 2024 SAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQK 2083
+ + LL+ Q L+K E ++EF + +K+ +S + + + Q+
Sbjct: 7377 FSKLQSFLLQHQTFLEKCE-TWMEFLVQTE------QKLAVEISG-----NYQHLLEQQR 7424
Query: 2084 DHEDFLASL-ARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEERE 2142
HE F A + +R Q +++ + ++ V L + +L W+ + ++R
Sbjct: 7425 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 7484
Query: 2143 QELQKEEARQVKNFEMCQEFEQNASTFLQWILE 2175
+ + Q + + A +W++E
Sbjct: 7485 GIIDSQ-------IRQWQRYREMAEKLRKWLVE 7510
Score = 98.2 bits (243), Expect = 9e-20
Identities = 325/1723 (18%), Positives = 647/1723 (37%), Gaps = 253/1723 (14%)
Query: 83 DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHI----EELRH 138
D ++Q + Q LE ++ K + E+EK + + + E+ + + EL
Sbjct: 6982 DQASVQNALKDCQDLEDLIKAKEK---EVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQ 7038
Query: 139 LW----------DLLLELTLEKGDQLLRAL-KFQQYVQECADILEWI----GDKEAIATS 183
W +LL+ L++ A K Y+ E L G EA+
Sbjct: 7039 TWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQ 7098
Query: 184 VELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQN--- 240
V+ ++ Q +L +E + + N+ +E HP P+ ++ N
Sbjct: 7099 VD-------------NLQNLQDDLEKQERSLQKFGSITNQLLKECHP--PVTETLTNTLK 7143
Query: 241 EVNAAWERL-RGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEP-------VLTSEDY 292
EVN W L +A Q Q + + QR+K + ++++E T++D
Sbjct: 7144 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 7203
Query: 293 GKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSW 352
D VA+ L + L + D + L E+L DA ++ D +S
Sbjct: 7204 ADDEVAT--WIQDCNDLLKGLGTVKDSLFFLHELGEQL--KQQVDASAASAIQSDQLSLS 7259
Query: 353 EHIRALATS---RYEKLQATYW-YHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVL 408
+H+ AL + + LQA Y F+ + L W+ E + + P+ + +
Sbjct: 7260 QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQD-PSHSSDLSTI 7318
Query: 409 LDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDER 468
+R ++ K ++ + D + + +D+ ++M+ L+ +W+ + ER
Sbjct: 7319 QERMEELKGQMLKFSSMAPDLDRLNE--LGYRLPLNDKEIKRMQNLNRHWSLISSQTTER 7376
Query: 469 HRQYEQCLDFHLFYRDSEQVDSWMS---RQEAFLENEDLGNSLGSAEALLQKHEDFEEAF 525
+ + L H + E+ ++WM + E L E GN E + HE F+
Sbjct: 7377 FSKLQSFLLQHQTFL--EKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ-RAHELFQAEM 7433
Query: 526 TAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARR-DALREKAATRRRLLKESLLL 584
++++ + ++ +L+ D + ++ LL+ + + +A RR ++ +
Sbjct: 7434 FSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQ 7493
Query: 585 QKLYED-SDDLKNWINKKKKLADDE------DYKDIQNLKSRVQ-KQQVFEKELAVNKTQ 636
+ Y + ++ L+ W+ + L + + L VQ K++VF ++ +
Sbjct: 7494 WQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG---SY 7550
Query: 637 LENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQF---- 692
+ ++ Q ++ A + L+E+ W K +L E ++L F
Sbjct: 7551 ILTVEAGKQLLLSADSGAEAALQAELAEIQEKW-------KSASMRLEEQKKKLAFLLKD 7603
Query: 693 ----ENNAEDLQRWLEDVEWQVTSE--DYGKGLAEVQNRLRKHGLLESAVAARQD---QV 743
E D L + +++ D+ + L Q R ++ LE+AV + D Q+
Sbjct: 7604 WEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE---LENAVGSWTDDLTQL 7660
Query: 744 DILTD-LAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT 802
+L D L+AY I D + R E L ++E L L+ R++++ + L+ + +
Sbjct: 7661 SLLKDTLSAY---ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7717
Query: 803 EDEEA-WIQETEPSATST----------YLGKDLIASKKLLNRHRVILENI------ASH 845
E W+ + E + L KD + +++ L+ + ASH
Sbjct: 7718 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASH 7777
Query: 846 EPRIQEITERGNKMVEEGHFAAEDVASRVK----------SLNQNMESLRARAARRQNDL 895
E + EI + K+ + + +A+RVK L++NM SLR A +++L
Sbjct: 7778 ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 7837
Query: 896 EANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSM 955
+ + + E + + E++ + + ++L E L D +
Sbjct: 7838 AKPIVYDS--CNSEEIQRKLNEQQEL--QRDIEKHSTGVASVLNLCEVLLHDCD------ 7887
Query: 956 KALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWW 1015
A A QQA + R + + R E T + S +DW
Sbjct: 7888 -ACATDAECDSIQQA--TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 7944
Query: 1016 KVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLL------- 1068
K + + +A +E +R+ +TQ E I QYR L
Sbjct: 7945 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ-LELINKQYRRLARENRTDS 8003
Query: 1069 ---------------DRAEERRRRLLQRYNEFLLAYE-----AGDMLEWIQEKKAENTGV 1108
D ++R +L+R F+ E +L W+ E + T +
Sbjct: 8004 ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 8063
Query: 1109 ELDDVWELQKKFDE---FQKDLNTNEPRLRDINKVADDL------LFEGLLTPEGAQIRQ 1159
E ++Q K + FQ++++ N ++ I + L L ++ E ++R+
Sbjct: 8064 EHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 8123
Query: 1160 ELNSRWGSLQR---------LADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAAD 1210
+G ++R L D++ L S +E+ A ++ +L +
Sbjct: 8124 YCQEVFGRVERYHKKLIRLPLPDDEHDL--SDRELELEDSAALSDLHWHDRSADSLLSPQ 8181
Query: 1211 PGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEA 1270
P S+L A R E RD D + + + LS D + R +E
Sbjct: 8182 PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSR---DLESAMSRALPSEDEE 8238
Query: 1271 WED-----LQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIE 1325
+D L+G + E+ + Y+ L+ +N I + G S+ E G
Sbjct: 8239 GQDDKDFYLRGAVGLSDVMIPESPEAYVKLT-----ENAIKNTSGDHSALESQIRQLGKA 8293
Query: 1326 ILLERHQEHRAD--MEAEAPTFQALE-------------DFSAELIDSGHHASPEIEKKL 1370
+ R Q + + + ++ PT L+ S + + H E E+ L
Sbjct: 8294 LDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 8353
Query: 1371 QA-VKLERDDLEKA-----WE--------KRKKILDQCLELQMFQGNCDQVESWMVAREN 1416
V L + + A WE K ++ + Q F + + + +W+ E
Sbjct: 8354 PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 8413
Query: 1417 SL----RSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIA 1472
L R + + + ++E +KK +L KA+ ++ I + + + ++
Sbjct: 8414 ELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQ 8473
Query: 1473 TRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRD--------LEELEEWISEMLPTAC 1524
RL ++ RW + + L + R L D Q + + LE ++ +E++P
Sbjct: 8474 DRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPI-- 8531
Query: 1525 DESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQ 1584
+S DA +Q + + HE+ +V + ++ L+ + EA KE++
Sbjct: 8532 -DSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHV 8589
Query: 1585 LKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAE 1627
+ LL+ + + + E + ++S +D W S E
Sbjct: 8590 IGNRLKLLLKEVS---RHIKELEKLLDVSSSQQDLSSWSSADE 8629
Score = 97.4 bits (241), Expect = 1e-19
Identities = 392/2099 (18%), Positives = 788/2099 (37%), Gaps = 238/2099 (11%)
Query: 63 DDLGKWIMEKVNILTDKSYEDPTNIQGKY---QKHQSLEAEVQTKSRLMSEL-------- 111
+ L +W ME V+ + + ++ K+ QS+ +E + +R + L
Sbjct: 2750 NQLEQW-MESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELY 2808
Query: 112 EKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADIL 171
EKT +E F +A EE K ++ + + + K +++++ Y+ +
Sbjct: 2809 EKTEDESFK--DTAQEELKTQFNDIM----TVAKEKMRKVEEIVK--DHLMYLDAVHEFT 2860
Query: 172 EWIGD-KEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHP 230
+W+ KE + ++ D T+ K ++ R+ V A E +
Sbjct: 2861 DWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTA 2920
Query: 231 D-LPLIQSKQNEVNAAWERLRGLALQRQKALSN-----AANLQRFKRDVTEAIQWIKEKE 284
L+ ++ + A W++ Q Q L N A + Q F V + Q +++
Sbjct: 2921 SGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFS 2980
Query: 285 PVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELC---AKAEKLTLSHPSDAPQI 341
+L + + + L EG K + + K +E+ KAE T S ++
Sbjct: 2981 ALLKT--WAQQLTLLEG-----KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNEL 3033
Query: 342 QEMKEDLVSSWEHIRALA---------TSRYEKLQATYWYHRFSSDFDELSGWM-NEKTA 391
DL + + L S+ + + RF F + W+ N K
Sbjct: 3034 CRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKIT 3093
Query: 392 AINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEV---- 447
++P +++ L + Q+ F S E GQ +N + +
Sbjct: 3094 TAKCFDIPQNISEVSTSLQKIQE-----------FLSESENGQHKLNMMLSKGELLSTLL 3142
Query: 448 -REKMEILDNNWTALLELWDERH---RQYEQCLD-----FHLFYRDSEQVDSWMSRQEAF 498
+EK + + TA E W H Q E L+ F +E + W+S+ E
Sbjct: 3143 TKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKM 3202
Query: 499 L-ENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSE---NIK 554
+ E+ + L + QK + E E ++ + + A +L +
Sbjct: 3203 VHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVS 3262
Query: 555 AIRDGLLARRDALREKAATRRRLLKE----SLLLQKLYEDSDDLKNWINKKKKLADDEDY 610
+ LA + +EK + R++ E SL +++L + D + ++ D+
Sbjct: 3263 QLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSV 3322
Query: 611 KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEG-GHYASDNVTTRLSEVASLW 669
D + LK EKE+ Q++ I G+ +++ + +L V +W
Sbjct: 3323 LDSRTLKLEALLSVKQEKEI-----QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMW 3377
Query: 670 EELLEATKQKGTQLHEA-NQQLQFENNAEDLQRWLEDVEWQVT-SEDYGKGLAEVQNRLR 727
LL A + +QL A ++ +++ W++ +E + SE L + L
Sbjct: 3378 ASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLG 3437
Query: 728 KHGLLESAVAARQDQVDILTDLAAYFEE--IGHPDSKDIRARQESLVCRFEALKEPLATR 785
K LL V + ++ + A E + + +D++ R ++ E KE A
Sbjct: 3438 KAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQ---ERAKE--AVT 3492
Query: 786 KKKLLDLLHLQLICRDTEDEEAWI-QETEPSATSTYLGKDLIASKKLLNRHRVILENIAS 844
K + L LH Q RD + E W+ QE E + L D + L + + + A
Sbjct: 3493 KSEKLVRLH-QEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAE 3551
Query: 845 HEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQY 904
+ + + ++ G AED A ++SL Q+ ++ + R + + V +
Sbjct: 3552 GQALLNSVLHTREDVIPSGIPQAEDRA--LESLRQDWQAYQHRLSETRTQFNNVVNKLRL 3609
Query: 905 LAD-LHEAETWIR---EKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRN 960
+ + + W++ EK+ + T Y + E GA ++ +LD + M
Sbjct: 3610 MEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQE----ILDESHVNSRMGCQAT 3665
Query: 961 QANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAA 1020
Q + Q V EQ + Q+ E ++ S DW+
Sbjct: 3666 QLTSRYQALLLQVL----EQIKFLEEEIQSLEESESSL----------SSYSDWYGSTHK 3711
Query: 1021 DHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQ 1080
+ + + + D+ + ++ + + + + + SLL A E+ R ++
Sbjct: 3712 NFKNVATKI-------DKVDTVMMGKKLKTLEVLLKDME---KGHSLLKSAREKGERAVK 3761
Query: 1081 RYNEF---LLAYEAGDMLEWIQE--KKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLR 1135
E L E D +E ++E + L+ L K+F + K L +
Sbjct: 3762 YLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQ 3821
Query: 1136 DINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDT 1195
+I L PE + + EL + L + Q+ +L +V+ + +
Sbjct: 3822 EI-----------LHVPE--EPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEAL 3868
Query: 1196 KEQIEK---KCQALSAADPGSDLFSV-QALQRRHEGFERDLVPLGDKV-TILGETAERLS 1250
E ++ K + DL S+ +A+ GFE L L K T++G+ A+ L
Sbjct: 3869 LELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHL- 3927
Query: 1251 ESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESL-NEAQKFYLFLSKARDLQNWISSIG 1309
+ K++ N LQG TKD ++ + AQ+ Y L +LQ +S
Sbjct: 3928 -----------QAKLKQN-VHAHLQG-TKDSYSAICSTAQRMYQSLE--HELQKHVSRQD 3972
Query: 1310 GMVSSQELAEDLTGIEILLERHQE---HRADMEAEAPTFQALEDFSAELID--------- 1357
+ Q+ L+ ++ LE + RA+ + F+AL++ + +D
Sbjct: 3973 TL---QQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLS 4029
Query: 1358 --SGHHASPEIEKKLQAVK---LERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMV 1412
S + +I++ Q ++ ++ +L + WE+ K + EL ++ + DQ
Sbjct: 4030 NASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKS---ELWIYLQDADQ------ 4080
Query: 1413 ARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIA 1472
+N R + L+ + ++ + D K + +++ + + L E + +
Sbjct: 4081 QLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEI 4140
Query: 1473 TRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDE---SYK 1529
L D+W L Q + + + + Y D + E E T D S
Sbjct: 4141 NHLN---DQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDA 4197
Query: 1530 DATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHW 1589
++T + + LK A + R + + + +IE D ++E +KEQ L++ W
Sbjct: 4198 ESTAVHLEALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLD-DKELVKEQTSHLEQRW 4254
Query: 1590 DHLLERTNDKGK-KLNEASRQQRFNTSIRDFEFWLSEAETLLAMK-DQARDLASAGNLLK 1647
L + K + + + ++ W E + +A Q+ A NLL
Sbjct: 4255 FQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLM 4314
Query: 1648 KHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLN-VQELAAAHH 1706
H + E+ A++ LK L A+ +++ N Q+++K + + +N + +L
Sbjct: 4315 DHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRR 4374
Query: 1707 EKLKEAYA-LFQFFQDLDDEESWIEEKLIRVSSQDYGRDL-QGVQNLLKKHKRLEGELVA 1764
+ L +A + QF + S I++ ++ +++ L V +K K + L
Sbjct: 4375 KYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKT 4434
Query: 1765 HEPAIQNVLDMA-EKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESL-EYL 1822
++ + + E +K+ + E+ +L + ++ + + R +LE++L
Sbjct: 4435 YQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRK 4494
Query: 1823 QFMQNAEEEEAWIN--------EKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETR 1874
F ++ ++ W+ E N + + LA Q++L + EN +
Sbjct: 4495 HFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRT 4554
Query: 1875 VQNVCAQGEDILNKVLQEE--SQNKEISSKIEALNEKTPSLAKAIAAWK-------LQLE 1925
Q + ++ + L E+ + ++ + + +K + +AI A K L +
Sbjct: 4555 GQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQ 4614
Query: 1926 DDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERL 1985
+ + V +A +E +G A L + L D L+ + F+
Sbjct: 4615 SLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQ 4674
Query: 1986 PEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQ--KLLEKQLPLQKAE 2042
P D L++ H + E+R + L E A H + + LE+QL K E
Sbjct: 4675 PWQPDKMLHLVTLYHRLKRQTEQRVSLL----EDTTSAYQEHEKMCQQLERQLKSVKEE 4729
Score = 94.4 bits (233), Expect = 1e-18
Identities = 414/2210 (18%), Positives = 848/2210 (38%), Gaps = 319/2210 (14%)
Query: 235 IQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGK 294
+Q +++ W+ L+G A L RF V E + ++E L ++ +
Sbjct: 1004 LQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTEL-DRETKLMPQEGSE 1062
Query: 295 DLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEH 354
++ +F S KG ++ELC K L + P +++ + +
Sbjct: 1063 KIIKEHRVFFSDKGPHHLCEKRLQLIEELCVK---LPVRDP-----VRDTPGTCHVTLKE 1114
Query: 355 IRALATSRYEKL-QATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQ 413
+RA S Y KL + + ++S F E S W++ + + G + H
Sbjct: 1115 LRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKG------IKGEAIDTANHG 1168
Query: 414 QHKHEIDSYDDRFQSADETGQDL---------VNANHEASDEVREKMEILDNNWTALLEL 464
+ K ++ + ET L V++ +EA + +++ L +++ AL+ L
Sbjct: 1169 EVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQ-GDELAKLSSSFKALVTL 1227
Query: 465 WDERHRQ---YEQCLDFHLFYRDS--EQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHE 519
E + + C+ + ++S E + QE + D N L A+ LL H+
Sbjct: 1228 LSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTEN-LFEAQQLLLHHQ 1286
Query: 520 DFEEAFTAQ----EEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRR 575
+ +A+ +++I + L H + +++ DGL R+ +
Sbjct: 1287 QKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTL 1346
Query: 576 RLLK-----ESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKEL 630
R + + +++ L++ + +++ + +++L S +++ + F K
Sbjct: 1347 RKWERFETNKETVVRYLFQTGSSHERFLS----------FSSLESLSSELEQTKEFSKRT 1396
Query: 631 AVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEEL--LEATKQKGTQLHE--A 686
Q EN+ K E+ G N + S+ E++ LE T ++ + E
Sbjct: 1397 ESIAVQAENLVKEASEIPLG----PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVK 1452
Query: 687 NQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDIL 746
+ F +N E L W+ + E ++ + + ++Q K + E + ++ + L
Sbjct: 1453 TKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQE--IESKLSSIVGL 1510
Query: 747 TDLAAYFEE-IGHPDSKDIRARQESLVCRFEALKE-----------PLATRKKKLLDLLH 794
+ A F + + +S I+A+ + E L+E L+ ++K +L
Sbjct: 1511 EEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRK 1570
Query: 795 LQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITE 854
+Q + ED+ A + SAT TY K+L H + + + S I +
Sbjct: 1571 IQQSVSEFEDKLAVPIKICSSATETY---------KVLQEHMDLCQALESLSSAITAFSA 1621
Query: 855 RGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE-ANVQFQQYLADLHEAET 913
K+V E A L Q E + RA RQ LE +Q+ +L T
Sbjct: 1622 SARKVVNRDSCVQEAAA-----LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLT 1676
Query: 914 WIREKE-----PIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQ 968
W+ E P +D + E L++ + ++ SF + L+ + +
Sbjct: 1677 WLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASK 1736
Query: 969 QAAPVEGVAGEQRVMALYDFQARSPREVTM--------KKGDVLTLLSSINKDWWKVEAA 1020
+ + EQ D + + ++ D L L S+ W K+ +
Sbjct: 1737 DDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSV---WIKLFLS 1793
Query: 1021 DHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSL-----LDRAEERR 1075
+ Q ++ + + R ++ + ++ ++++ L L RAE+
Sbjct: 1794 ELQ------TTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAED-- 1845
Query: 1076 RRLLQRYNE--FLLAYEAGDMLEWIQEKKAE-----NTGVELDDVWELQKKFDEFQKDLN 1128
LLQ E F L EA ++E Q + + L + ++ E +N
Sbjct: 1846 LHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMN 1905
Query: 1129 TNEPRL--RDINKVADD--------LLFEGLLTPEGAQIRQELNSRWGSLQRLADEQ--- 1175
NE L +D+N + + +G+L+ ++ + + S + AD+
Sbjct: 1906 KNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGE 1965
Query: 1176 ----RQLLGS----AHAVEVFHREADDTKEQIEKKCQALSAADPGSDLF--SVQALQRRH 1225
+ LLG+ A A+ V + D KE++ K + + L + QALQ+R
Sbjct: 1966 VERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRL 2025
Query: 1226 EGF---ERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDL-------Q 1275
F E +L ++ L + A+++++ ++ R+ L W+D Q
Sbjct: 2026 RVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQ 2085
Query: 1276 GRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHR 1335
G+ + + E Q +SK + + ++ ++ +D ++ +H+ +
Sbjct: 2086 GQCCGLIDLMREYQNLKSAVSKV------LENASSVIVTRTTIKDQEDLKWAFSKHETAK 2139
Query: 1336 ADMEAEAPTFQALEDFSAELIDSGHHASPEIEK----KLQAVKLERDDLEKAW----EKR 1387
M + + L++F+++ G H E++K VK + + W EK
Sbjct: 2140 NKMNYKQ---KDLDNFTSK----GKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKL 2192
Query: 1388 KKILDQC-LELQMFQ---GNCDQVESWMVARENSL--RSDDKSSLDS---LEALMKKRDD 1438
++ +D+ + L ++ D++E W N + +++ S+LD+ E L+K+ +
Sbjct: 2193 EENMDRLRVSLSIWDDVLSTRDEIEGW---SNNCVPQMAENISNLDNHLRAEELLKEFES 2249
Query: 1439 --LDKAITAQE--GKITDLEHFAESLIA--DEHYAKEEIATRLQRVLDRWKALKAQLIDE 1492
+KA+ +E K+ DL+ ++L D + + ++ +L+ + + K L D
Sbjct: 2250 EVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDF 2309
Query: 1493 RTKLGDYANLKQFYRDL----EELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEV 1548
+ +++F D+ ++EE + E+ K +IQ++ Q+ +
Sbjct: 2310 TAQ---STQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQS---NI 2363
Query: 1549 DGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASR 1608
E + NSL E + +K+H + + K + + S
Sbjct: 2364 SSTQENL-------NSLCRKYHSAELESLGRAMTGLIKKH--EAVSQLCSKTQASLQESL 2414
Query: 1609 QQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNT 1668
++ F+ S+++F+ W A+ A K+ + + L K L+ + + D L+
Sbjct: 2415 EKHFSESMQEFQEWFLGAKA--AAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDA 2472
Query: 1669 LAEDLLSSGTFNVDQIVKK-KDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEES 1727
+ ++ + QIV ++ + K +E A + LK+ AL +L E
Sbjct: 2473 VTQEGQTLYAHLSKQIVSSIQEQITKA---NEEFQAFLKQCLKDKQALQDCASELGSFED 2529
Query: 1728 -------WIEEKLIRVSSQDYGRDLQGV---QNLLKKHKRLEGELVAHEPAIQNVLDMAE 1777
WI E R ++++ G Q + +N + K + GEL+A ++ + +
Sbjct: 2530 QHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQ 2589
Query: 1778 KLKDKAAVGQEEIQLRLAQFVEHW-------EKLK--ELAKARGLKLEESLEYLQFMQNA 1828
L ++ +E +L H EKL+ ++A LEE+L+ + F A
Sbjct: 2590 LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKA 2649
Query: 1829 EEE-----EAWINEKNALAVRGDCGDTLAATQS-LLMKHEALENDFAVHETRVQNVCAQG 1882
++ E+ + K+ L R L+ Q LLMK E E ++ +G
Sbjct: 2650 IQDRLACAESTLGSKDTLEKR------LSQIQDILLMKGEG--------EVKLNMAIGKG 2695
Query: 1883 EDILNKVLQEESQNKE----ISSKIEALNEKTPSLAKAIAAWKLQLEDDYA-FQEFNWKA 1937
E L S NKE I +++E L E + + + LE + + ++ +
Sbjct: 2696 EQAL------RSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2749
Query: 1938 DVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLIS 1997
+ +E W+ + ++ L L K LD LQS E L +
Sbjct: 2750 NQLEQWMESVDQKIE-----HPLQPQPGLKEKFVLLD-HLQSILSEAEDHTRALHRLIAK 2803
Query: 1998 AQHNQSKAIEERY--AALLKRWEQLLEASAVHRQK------LLEKQLPLQKAEDLFVEFA 2049
++ K +E + A + Q + V ++K +++ L A F ++
Sbjct: 2804 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2863
Query: 2050 HKA-SALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQ 2108
H A L+ W + ++ + L++I++L E + L+R ++ E+ Q
Sbjct: 2864 HSAKEELHRWSDMSGDSSATQ---KKLSKIKELIDSREIGASRLSRVES---LAPEVKQN 2917
Query: 2109 IKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQEL----------QKEEARQVKNFEM 2158
A G ++ L WK D + + + L ++E + QV E
Sbjct: 2918 TTASG---CELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLE- 2973
Query: 2159 CQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218
Q EQ ++ W + +LL+ T E +E + Q+ + A+++ + D
Sbjct: 2974 -QALEQFSALLKTWAQQL-------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED 3025
Query: 2219 LGDNLEDALILDIKYSTI-----GLAQQWDQLYQLGLRMQHNLEQQIQAK 2263
L L + ST GL ++++ L + N EQ +Q +
Sbjct: 3026 LKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQR 3075
Score = 82.0 bits (201), Expect = 6e-15
Identities = 357/1985 (17%), Positives = 743/1985 (37%), Gaps = 279/1985 (14%)
Query: 337 DAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYW-YHRFSSDFDELSGWMNEKTAAINA 395
+A + + + + W ++ S L+ + R+ + L W+ + +N
Sbjct: 586 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 645
Query: 396 DELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHE-ASDEVREKMEIL 454
E + + + + + + ++ G L+ E S ++++++ +L
Sbjct: 646 SE------------NAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLL 693
Query: 455 DNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEAL 514
+ W L + +++ Q ++ Y D S + + +E L S + + L
Sbjct: 694 NGRWRELF-MEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLL 752
Query: 515 LQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATR 574
+Q ED E+ + + + KTA LI + E + + + K
Sbjct: 753 IQDLEDIEQRVPVMDAQYKIITKTA-HLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 811
Query: 575 RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNK 634
L + LL L E + ++ + K+ + I L+ Q +F+++
Sbjct: 812 PLLYESQQLLIPLEELEKQMTSFYDSLGKINEI-----ITVLEREAQSSALFKQKHQELL 866
Query: 635 TQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFEN 694
EN +KT +IE G + T LS V L+ Q Q A+ + F++
Sbjct: 867 ACQENCKKT-LTLIEKGSQSVQKFVT-LSNV-------LKHFDQTRLQRQIADIHVAFQS 917
Query: 695 NAEDLQRWLEDVEWQVT-SEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYF 753
+ W + VE + + + AE++ LR + + + + D ++L +F
Sbjct: 918 MVKKTGDWKKHVETNSRLMKKFEESRAELEKVLR---IAQEGLEEKGDPEELLRRHTEFF 974
Query: 754 EEIGH----------PDSKDIRARQESLVCRFEALKEPLATRKKKLLDL--------LHL 795
++ + DI QE + L+E + K+ DL LHL
Sbjct: 975 SQLDQRVLNAFLKACDELTDILPEQEQ-----QGLQEAVRKLHKQWKDLQGEAPYHLLHL 1029
Query: 796 QLICRDTEDEE--AWIQE--TEPSATSTYLGKDLIASKKLLNRHRVILENIASH---EPR 848
++ D E A ++E TE + + ++ S+K++ HRV + H E R
Sbjct: 1030 KI---DVEKNRFLASVEECRTELDRETKLMPQE--GSEKIIKEHRVFFSDKGPHHLCEKR 1084
Query: 849 IQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDL-EANVQFQQYLAD 907
+Q I E K+ + V + + ++ LRA L E +++ Y +
Sbjct: 1085 LQLIEELCVKLP-----VRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSR 1139
Query: 908 LHEAETWIREKEP--------IVDNTNYG----ADEEAAGALLKKHEAF---------LL 946
E +WI E +D N+G A EE + K+ E L
Sbjct: 1140 FSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLT 1199
Query: 947 DLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTL 1006
+++S ++ K A +A V ++ +++++ + + V ++++
Sbjct: 1200 EVSSENEAQKQGDELAKLSSSFKAL-VTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISG 1258
Query: 1007 LSSINKDWWKVEAAD-----------HQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQ 1055
+ + K+ + HQ + ++ D + Q ++ E G +
Sbjct: 1259 SKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKK--RDVQQQIAQAQQGEGGLPDR 1316
Query: 1056 RQEQIENQYRSL--LDRAEERRRRLLQ----RYNEF--------LLAYEAGDMLE-WIQE 1100
E++ +L L+R+ ER+ R +Q ++ F ++ G E ++
Sbjct: 1317 GHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSF 1376
Query: 1101 KKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE 1160
E+ EL+ E K R I A++L+ E P G Q +Q
Sbjct: 1377 SSLESLSSELEQTKEFSK--------------RTESIAVQAENLVKEASEIPLGPQNKQL 1422
Query: 1161 LNSRWGSLQ----RLADEQRQLLGSAHAVEV----FHREADDTKEQIEKKCQALSAADPG 1212
L + S++ +L D + + + V+ F + I +K + L+A +
Sbjct: 1423 LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETS 1482
Query: 1213 SDLFSVQALQRRHE------------GFERDLVPLGDKVTILGETAERLSESHPDATEDL 1260
S +Q Q + G E + VT GE+A ++ +
Sbjct: 1483 SSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTT-GESARIKAK-----LTQI 1536
Query: 1261 QRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQ-ELAE 1319
+R EL E + L+G L++ QKF R +Q +S ++ ++
Sbjct: 1537 RRYGEELREHAQCLEGTILGH---LSQQQKFE---ENLRKIQQSVSEFEDKLAVPIKICS 1590
Query: 1320 DLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDD 1379
T +L+ H + +E+ + A + ++++ ++ A++ + +D
Sbjct: 1591 SATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRD-----SCVQEAAALQQQYED 1645
Query: 1380 LEKAWEKRKKILDQCL-ELQMFQGNCDQVESWMV---ARENSLRSDDKSSLDSLEALMKK 1435
+ + ++R+ L+ L Q + +W+ A+ +S D + +E ++
Sbjct: 1646 ILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQL 1705
Query: 1436 RDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIAT---RLQRVLDRWKALKAQLIDE 1492
L + +Q + L ESL + +K+++ L+++ +RW+ L Q+I++
Sbjct: 1706 IQALQNEVVSQASFYSKLLQLKESLFSVA--SKDDVKMMKLHLEQLDERWRDLP-QIINK 1762
Query: 1493 RTKL--GDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDG 1550
R A +QF L WI L S + Q +H+ A EV+
Sbjct: 1763 RINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1822
Query: 1551 RSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLE-RTNDKGKKLNEASRQ 1609
+ ++ +L L + + E+ HLL+ + D + EAS+
Sbjct: 1823 KKGELQ---SLQGHLAKLGSLGRAEDL-------------HLLQGKAEDCFQLFEEASQV 1866
Query: 1610 -QRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQ--LLEREM---LAREDAL 1663
+R ++ +L +L + Q R A N + K++ L+E+++ L AL
Sbjct: 1867 VERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKAL 1926
Query: 1664 KDLNTLAEDLLSSGTFNV-----DQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF-- 1716
+ + +LS +++ +Q + ++ V+ + K EA AL
Sbjct: 1927 ESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVL 1986
Query: 1717 -QFFQDLDDEE----SWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQN 1771
+ FQD +E IEE+ + ++ R Q +Q L+ +LE EL +HE +
Sbjct: 1987 KKAFQDQKEELLKSIEDIEERTDKERLKEPTR--QALQQRLRVFNQLEDELNSHEHELCW 2044
Query: 1772 VLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEE 1831
+ D A+++ K E+ + + W+ K L + ++ ++ QN +
Sbjct: 2045 LKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSA 2104
Query: 1832 EAWI--NEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKV 1889
+ + N + + R D + KHE +N + + N ++G+ +L+++
Sbjct: 2105 VSKVLENASSVIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL 2163
Query: 1890 LQEESQN-----KEISSKI-------EALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKA 1937
+ S + ++ S + E L E L +++ W DD
Sbjct: 2164 KKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIW-----DDVLSTR----- 2213
Query: 1938 DVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERL-PEITDLKDKLI 1996
D +E W + + N + D L K+ + ++ + E L ++ DLK+ +
Sbjct: 2214 DEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKE--L 2271
Query: 1997 SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALN 2056
+ ++ A L+++ E E + V + L + + E + +
Sbjct: 2272 TKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFI-------NDIT 2324
Query: 2057 NWCEKMEE---NLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALG 2113
W K+EE N ++ C +L +++ +QK+ + ++++ Q + L
Sbjct: 2325 TWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCR--------- 2375
Query: 2114 VPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173
Y +E L R L E Q K +A ++ E + F ++ F +W
Sbjct: 2376 ----KYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWF 2429
Query: 2174 LETRA 2178
L +A
Sbjct: 2430 LGAKA 2434
Score = 82.0 bits (201), Expect = 6e-15
Identities = 139/773 (17%), Positives = 313/773 (40%), Gaps = 89/773 (11%)
Query: 2 EQFPKETVVES---SGPKVLETAE-----EIQERRQEVLTRYQSFKERVAERGQKLEDSY 53
E F ++ ++ S G ++LE + E + + ++Q R +R ++
Sbjct: 7432 EMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQI 7491
Query: 54 HL-QVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSE-- 110
Q ++ A+ L KW++E + P +Q + ++L EVQ K ++
Sbjct: 7492 RQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQ----QARTLFDEVQFKEKVFLRQQ 7547
Query: 111 ------LEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYV 164
+E ++ + A +A + E++ W E+ +L LK
Sbjct: 7548 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK----- 7602
Query: 165 QECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANEC 224
+W ++ IA S+E +++ L + D EL A++ R E+
Sbjct: 7603 -------DWEKCEKGIADSLEKLRTFKKK--LSQSLPDHHEELHAEQMRCKELENAVGSW 7653
Query: 225 AEE---------------NHPDLPLIQSKQNEVNAAWERL-RGLALQRQKALSNAANLQR 268
++ + D+ ++ + + WE L L+L+RQ+
Sbjct: 7654 TDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV 7713
Query: 269 FKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAE 328
F E +W+ + E ++ D++ E + K + +A+ + +L E
Sbjct: 7714 FSEKNKELCEWLTQMESKVSQNG---DILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGE 7770
Query: 329 KLT-LSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQAT-YWYHRFSSDFDELSGWM 386
+L SH S A +I+ + W+H+ L +R +KL+ T + + L W+
Sbjct: 7771 RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL 7830
Query: 387 NEKTAAINADELPTDVAGGEVL---LDRHQQHKHEIDSYDDRFQSADETGQDLVN----- 438
+ + A + D E + L+ Q+ + +I+ + S + L++
Sbjct: 7831 AHIESEL-AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDAC 7889
Query: 439 ANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLD-FHLFYRDSEQVDSWMSRQE- 496
A D +++ LD W + + ER + E+ + F D + + W+ E
Sbjct: 7890 ATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 7949
Query: 497 --AFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSE-NI 553
AF + + ++ E L+K E F+ ++ ++K +L ++ DS ++
Sbjct: 7950 TAAFPSSSGVIYTVAKEE--LKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 8007
Query: 554 KAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDS-DDLKNWINKKKKLADDEDYKD 612
K + R D L+++ + R LK + ++ +E + D + W+ + + ++
Sbjct: 8008 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 8067
Query: 613 IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGH-YASDNVTTRLSEVASLWEE 671
++++++++ + F++E+++N ++E I G+++IE + + L E+ +E
Sbjct: 8068 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 8127
Query: 672 LLEATKQKGTQL---------HE-ANQQLQFENNAEDLQRWLEDVEWQVTSED 714
+ ++ +L H+ ++++L+ E++A L D+ W S D
Sbjct: 8128 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAA-----LSDLHWHDRSAD 8175
Score = 73.9 bits (180), Expect = 2e-12
Identities = 258/1302 (19%), Positives = 485/1302 (37%), Gaps = 211/1302 (16%)
Query: 1108 VELDDVW-ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWG 1166
+E D W + +F EF ++TNE +L+ I A D G + +IR + R
Sbjct: 1127 MEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGE 1186
Query: 1167 SL-------------------QRLADEQRQLLGSAHAVEVFHREAD----------DTKE 1197
+L Q+ DE +L S A+ E + KE
Sbjct: 1187 TLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKE 1246
Query: 1198 QIEKKCQALSAAD-----------PGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETA 1246
++ + L + +LF Q L H+ + + V A
Sbjct: 1247 IVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQA 1306
Query: 1247 ERLSESHPDATEDLQRQKMELNEAWEDLQG--RTKDRKESLNEA--QKFYLFLSKARDLQ 1302
++ PD R EL + L G R+++R+E + +K+ F + +
Sbjct: 1307 QQGEGGLPD------RGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVV 1360
Query: 1303 NWISSIGGMVSSQELAEDLTGIEIL---LERHQEHRADMEAEAPTFQALEDFSAELIDSG 1359
++ G SS E + +E L LE+ +E E+ A + L ++E I G
Sbjct: 1361 RYLFQTG---SSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1416
Query: 1360 HHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQC-LELQMFQGNCDQVESWMVARENSL 1418
++++ +++K + LE E+ K ++ + F N + + W+ +E L
Sbjct: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
Query: 1419 RSDDKSS--LD-SLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRL 1475
+ + SS +D + + +++ +++ G + + FA+ + E + T++
Sbjct: 1477 NALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQI 1536
Query: 1476 QRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEM-----LPTACDESYKD 1530
+R + + AQ + E T LG + ++F +L ++++ +SE +P S
Sbjct: 1537 RRYGEELRE-HAQCL-EGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSS--- 1591
Query: 1531 ATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWD 1590
AT + +H ++ S + ++ +C A+++Q E
Sbjct: 1592 ATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYED------ 1645
Query: 1591 HLLERTNDKGKKL-NEASRQQRFNTSIRDFEFWL--SEAETLLAMKDQARDLASAGNLLK 1647
+L R ++ L N + QR + F WL EA+ D + D L+
Sbjct: 1646 -ILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQ 1704
Query: 1648 KHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHE 1707
Q L+ E++++ L L E L S V KD+V L++++L +
Sbjct: 1705 LIQALQNEVVSQASFYSKLLQLKESLFS---------VASKDDVKMMKLHLEQLDERWRD 1755
Query: 1708 KLKEAYALFQFFQDLDDEESWIEEKLIRVS--SQDYGRDLQGVQNLLKKHKRLEGELVAH 1765
+ F Q + E +E L+ S + + +LQ + ++ H
Sbjct: 1756 LPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEI---------SIMDH 1806
Query: 1766 EPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFM 1825
+ A+ D A +++ K L H KL L +A L L + F
Sbjct: 1807 QVALTRHKDHAAEVESKKG--------ELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCF- 1857
Query: 1826 QNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGE-- 1883
EE + + E+ LA L+ L H +L V+ + +
Sbjct: 1858 -QLFEEASQVVERRQLA--------LSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNE 1908
Query: 1884 -DILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEA 1942
D++ K L + QN +AL SL ++ + L+ + Q + +A +
Sbjct: 1909 SDLIEKDLNDALQN------AKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRA-TADQ 1961
Query: 1943 WIADKETSLKTNGNGADLGDFLTLLAK--QDTLDASLQSFQ------------------- 1981
+ E G D L +L K QD + L+S +
Sbjct: 1962 LCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQAL 2021
Query: 1982 QERLPEITDLKDKLISAQH------NQSKAIEER---YAALLKRWEQLLEASAVHRQKLL 2032
Q+RL L+D+L S +H +++K I ++ +A + R LE + ++L+
Sbjct: 2022 QQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLI 2081
Query: 2033 -EKQLPLQKAEDLFVEFAHKASALNNWCE------------KMEENL--SEPVHCVSLNE 2077
E Q DL E+ + SA++ E K +E+L + H + N+
Sbjct: 2082 HENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNK 2141
Query: 2078 IRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTV-EVLERTWKHLSD 2136
+ QKD ++F + ++ K + D + + S+ WL V E LE L
Sbjct: 2142 MNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRV 2201
Query: 2137 IIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQL 2196
+ + L + + + + +N S LD L E E +
Sbjct: 2202 SLSIWDDVLSTRDEIEGWSNNCVPQMAENISN------------LDNHLRAEELLKEFES 2249
Query: 2197 EANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNL 2256
E K K ++ + ++ + +L NLE D+++ L Q +++H
Sbjct: 2250 EV-KNKALRLEELHSKVNDLKELTKNLETP--PDLQFIEADLMQ----------KLEH-- 2294
Query: 2257 EQQIQAKDIKGVSEETLKEF---STIYKHFDENLTGRLTHKE 2295
AK+I V++ TLK+F ST + F ++T T E
Sbjct: 2295 -----AKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVE 2331
Score = 68.6 bits (166), Expect = 7e-11
Identities = 248/1276 (19%), Positives = 495/1276 (38%), Gaps = 204/1276 (15%)
Query: 1093 DMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTP 1152
+M WI++ + + T ++ + LQ K+ F+ E + + I + L +G L+
Sbjct: 329 EMKVWIEQFERDLTRAQMVES-NLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSL 387
Query: 1153 EGAQIRQELNSRWGSL-QRLADEQRQL-------LGSAHA----VEVFHREADDTKEQIE 1200
+ A ++Q W + RL D QL LG+ A EV RE ++ E
Sbjct: 388 DQALVKQS----WDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHE 443
Query: 1201 KKCQALSAA-DPGSDLFSVQALQRR--HEGFE-RDLVPLGDKVTILGETAERLSESHPDA 1256
+ + + DL +R HE + R + + L + AER +
Sbjct: 444 ETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFH--FVSS 501
Query: 1257 TEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQE 1316
T +L KME E K R SL L L++++ L++WI G S ++
Sbjct: 502 TSELHLMKMEFLEL--------KYRLLSL-------LVLAESK-LKSWIIKYGRRESVEQ 545
Query: 1317 LAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELI--DSGHHASPEIEKKLQAVK 1374
L ++ E+ E T+Q L+ + + D + + K +
Sbjct: 546 LLQNYVSFI-------ENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETT 598
Query: 1375 LERDDLEKAWEKRKKILDQCLELQMFQGNC-DQVESWMVARENSLRSDDKSSLDSLEAL- 1432
+ +L + +L++ + GN +++W+ E L + + D L
Sbjct: 599 AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 658
Query: 1433 --MKKRDDLDKA-----ITAQEGKITDLEH--------FAESLIADEHYAKEEIATRLQR 1477
+++ ++ A T E DL+ + E + + YA+ + R+++
Sbjct: 659 HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 718
Query: 1478 -VLDRWKALKAQLIDERTKLGD-----YANLKQFYRDLEELEEWISEMLPTACDESYKDA 1531
D L A + KL + + N+K +DLE++E+ + M D YK
Sbjct: 719 EYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVM-----DAQYKII 773
Query: 1532 TNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDH 1591
T AH + S Q G +KEQL ++KE +
Sbjct: 774 TKT----------AHLITKESPQEEG-----------KEMFATMSKLKEQLTKVKECYSP 812
Query: 1592 LLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQL 1651
LL + L E +Q TS D ++E T+L R+ S+ +KHQ
Sbjct: 813 LLYESQQLLIPLEELEKQM---TSFYDSLGKINEIITVLE-----REAQSSALFKQKHQ- 863
Query: 1652 LEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRF------LNVQELAAAH 1705
E+LA ++ K TL E G+ +V + V NV K F + ++ A
Sbjct: 864 ---ELLACQENCKKTLTLIE----KGSQSVQKFVTLS-NVLKHFDQTRLQRQIADIHVAF 915
Query: 1706 HEKLKEAYALFQFFQDLDD-----EESWIE-EKLIRVSSQDYGRDLQG-VQNLLKKHKRL 1758
+K+ + + EES E EK++R++ + G + +G + LL++H
Sbjct: 916 QSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQE--GLEEKGDPEELLRRHTEF 973
Query: 1759 EGELVAHEPAIQNVLDMAEKLKDKAAVGQEE-IQLRLAQFVEHWEKLKELAKARGLKLEE 1817
+L + + L ++L D +++ +Q + + + W+ L+ A L L+
Sbjct: 974 FSQL--DQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKI 1031
Query: 1818 SLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQN 1877
+E +F+ + EE ++ + L + ++ ++ +H +D H +
Sbjct: 1032 DVEKNRFLASVEECRTELDRETKLMPQ-------EGSEKIIKEHRVFFSDKGPH-----H 1079
Query: 1878 VCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAI-AAWKLQLEDDYAFQEFNWK 1936
+C + ++ ++ + + + L AI + ++ +ED ++++ +
Sbjct: 1080 LCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSR 1139
Query: 1937 ADVVEAWIADKETSLK-------TNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEIT 1989
+WI+ ET LK N ++ + + T S+ + RL +T
Sbjct: 1140 FSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLT 1199
Query: 1990 DL-KDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEF 2048
++ + Q ++ + + AL+ ++ + + + K++ E+L
Sbjct: 1200 EVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELI--- 1256
Query: 2049 AHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQ 2108
+ ++++E + + +L E +QL H+ ++ + D + + QQ
Sbjct: 1257 --------SGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQ 1308
Query: 2109 IKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNAST 2168
+ G+P + L + L ++ E+ +++E R + FE N T
Sbjct: 1309 GEG-GLPDRGHEEL---------RKLESTLDGLERSRERQERRIQVTLRKWERFETNKET 1358
Query: 2169 FLQWILET---RAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLED 2225
++++ +T FL S L+ +L S+LE K K +++ Q +V
Sbjct: 1359 VVRYLFQTGSSHERFLSFSSLE---SLSSELEQTKEFSKRTESIAVQAENLVK------- 1408
Query: 2226 ALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEE---TLKEFSTIYKH 2282
+ S I L Q QL Q + ++++Q+ K ++ EE T++ T + H
Sbjct: 1409 ------EASEIPLGPQNKQLLQ---QQAKSIKEQV--KKLEDTLEEDIKTMEMVKTKWDH 1457
Query: 2283 FDEN---LTGRLTHKE 2295
F N L+ +T KE
Sbjct: 1458 FGSNFETLSVWITEKE 1473
Score = 63.2 bits (152), Expect = 3e-09
Identities = 407/2262 (17%), Positives = 855/2262 (37%), Gaps = 311/2262 (13%)
Query: 189 DWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWER 248
D E E HK E L E R ++ NE + + + +V+ +
Sbjct: 2999 DEEIVECWHKGQEILDA-LQKAEPRTEDLKSQLNELCRFSRD----LSTYSGKVSGLIKE 3053
Query: 249 LRGLALQRQKALSNAANL--QRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSH 306
L LQ K N + QRF++ + QW+ + + T++ + SE + S
Sbjct: 3054 YNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAK-ITTAKCFDIPQNISE-VSTSL 3111
Query: 307 KGLERNLAVMSD---KVKELCAKAEKL-TLSHPSDAPQIQEMKEDLVSSWEHIRALATSR 362
+ ++ L+ + K+ + +K E L TL A IQ W++ + +
Sbjct: 3112 QKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQK 3171
Query: 363 YEKLQATYWYHR-FSSDFDELSGWMN--EKTAAINADELPTDVAGGEVLLDRHQQHKHEI 419
L+ + F + + W++ EK +++ L D+ + Q EI
Sbjct: 3172 ESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRL-YDLPAKRREQQKLQSVLEEI 3230
Query: 420 DSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFH 479
Y+ + E Q L AS R ++ L + + AL L E+ + ++ + H
Sbjct: 3231 HCYEPQLNRLKEKAQQLWEGQ-AASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEH 3289
Query: 480 -LFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKT 538
F +++ WM+ +A + + L + E + ++EK I +
Sbjct: 3290 NQFSLGIKELQDWMT--DAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMI 3347
Query: 539 ATKLIGDD---HYDSENIKAIRDGLLARRD---ALREKAATRRRLLKESLLLQKLYEDS- 591
T+ G+ + E I I+ L + +D +L + L+ +L Y+D
Sbjct: 3348 VTR--GESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGV 3405
Query: 592 DDLKNWINKKKKLADDED--YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIE 649
W++ + ++ + + ++++ + + K ++ +E+ + LE I+ G M E
Sbjct: 3406 RQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE 3465
Query: 650 GGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQ 709
HY + L E +E + K +L +Q+ Q + A ++ WL + +
Sbjct: 3466 --HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEV--WLGQEQEK 3521
Query: 710 V-----------TSEDYGKGLAEVQNRLRK-HGLLESAVAARQDQV-------------D 744
+ T E + L E+Q + LL S + R+D +
Sbjct: 3522 LDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALES 3581
Query: 745 ILTDLAAYFEEIGHPDSK--DIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT 802
+ D AY + ++ ++ + + +F+ + E L T ++K H ++
Sbjct: 3582 LRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKKW---HEEVTAYRD 3638
Query: 803 EDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRV----ILENIASHEPRIQEITERGNK 858
E EE + E S + + +L +R++ +LE I E IQ + E +
Sbjct: 3639 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3698
Query: 859 MVEEG------HFAAEDVASRVKSLNQNMESLRARAAR-RQNDLE--------ANVQFQQ 903
+ H ++VA+++ ++ M + + D+E A + ++
Sbjct: 3699 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3758
Query: 904 YLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLN---SFGDSMKALRN 960
+ L E E KE I D+ +E + K+H L+ F D KAL
Sbjct: 3759 AVKYLEEGEAERLRKE-IHDHMEQL--KELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQ 3815
Query: 961 QANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAA 1020
Q+ P E+ M LY+ +A+ + ++++ VL+ S+ K EA
Sbjct: 3816 WIAEYQEILHVP------EEPKMELYEKKAQLSKYKSLQQ-TVLSHEPSVKSVREKGEAL 3868
Query: 1021 DH--QGIVPAVYVRRLAHD--EFPMLPQRRREEPGNITQRQEQIENQYRSLLDR-AEERR 1075
Q + + +L D + + + EE R ++ + +L+ + A+ +
Sbjct: 3869 LELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ 3928
Query: 1076 RRLLQRYNEFLLAY-EAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRL 1134
+L Q + L ++ + ++ ++ EL Q + Q L+ +P L
Sbjct: 3929 AKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDL 3988
Query: 1135 RDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLG--------SAHAVE 1186
+P+ R E + + L ++ R L S +V+
Sbjct: 3989 EP--------------SPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVK 4034
Query: 1187 VFHREADDTKEQIEKKCQALSAADPG--------SDLF--------SVQALQRRHEGFER 1230
++ T++ IE+K G S+L+ +Q ++RRH E
Sbjct: 4035 TTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELEL 4094
Query: 1231 DLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTK-----DRKE-- 1283
++ A+ + D + LQ ++ +N E + TK + KE
Sbjct: 4095 NI-------------AQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEIN 4141
Query: 1284 SLNEA------QKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEH--- 1334
LN+ Q L L + DLQ +++ + + +E+ LE+
Sbjct: 4142 HLNDQWLDLCRQSNNLCLQREEDLQR----------TRDYHDCMNVVEVFLEKFTTEWDN 4191
Query: 1335 --RADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVK-LERDD----------LE 1381
R+D E+ A +AL+ + L + + ++K + ++ L DD LE
Sbjct: 4192 LARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLE 4251
Query: 1382 KAWEKRKKILDQCL--------ELQMFQGNCDQVESWMVARENSLRSDDKSSL--DSLEA 1431
+ W + + ++ + + EL + Q ++ W ++ ++ K S D +
Sbjct: 4252 QRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQN 4311
Query: 1432 LMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLID 1491
L+ + + A++ + L A+ ++AD + ++ + + L+
Sbjct: 4312 LLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVG 4371
Query: 1492 ERTKLGDYA--NLKQFYRDLEELEEWISE------------MLPTACDESYKDATNIQRK 1537
+R K + A QF + + I + +LP + K + Q
Sbjct: 4372 QRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQAS 4431
Query: 1538 YLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTN 1597
+T+ +EV G Q G L++ + + + +L++L+ +D +L++ +
Sbjct: 4432 L---KTYQNEVTGLWAQ-------GRELMK-EVTEQEKSEVLGKLQELQSVYDSVLQKCS 4480
Query: 1598 DKGKKL--NEASRQQRFNTSIRDFEFWLSEAETL----LAMKDQARDLASAGNLLKKHQL 1651
+ ++L N SR+ F WL +A+ + + + +++ +L + L K+Q
Sbjct: 4481 HRLQELEKNLVSRKH-FKEDFDKACHWLKQADIVTFPEINLMNESSELHTQ---LAKYQN 4536
Query: 1652 LEREMLAREDALKDLNTLAEDLLSS-GTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLK 1710
+ + E+ L L + +L S + + +K + + ++F + LA K++
Sbjct: 4537 ILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQ 4596
Query: 1711 EAYALFQFFQDLDD----EESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHE 1766
EA + + L + S +E + +R+S ++ +L + + E+
Sbjct: 4597 EAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLG 4656
Query: 1767 PAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQF-- 1824
A+ + E + Q + L L V + +LK + R LE++ Q
Sbjct: 4657 EAVDELNQKKEGFRSTGQPWQPDKMLHL---VTLYHRLKRQTEQRVSLLEDTTSAYQEHE 4713
Query: 1825 ---------MQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRV 1875
+++ +EE++ +NE +TL A + L M H +L +
Sbjct: 4714 KMCQQLERQLKSVKEEQSKVNE-----------ETLPAEEKLKMYH-SLAGSLQDSGIVL 4761
Query: 1876 QNVCAQGEDILNKV--LQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQ-E 1932
+ V ED+ + L E +I S L T ++ + + + ++ FQ E
Sbjct: 4762 KRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTE 4821
Query: 1933 FNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLA-KQDTLDASLQSFQQERLPEITDL 1991
+ D + A+ + + N D+ + + + Q+ + +SL+ E
Sbjct: 4822 MSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKE---- 4877
Query: 1992 KDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHK 2051
K+K A+ S +E A L + + EA + L E Q+ +F
Sbjct: 4878 KEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVF------ 4931
Query: 2052 ASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKA 2111
A N+W E +E L + + + + K H +F ++ + ++ + L L +
Sbjct: 4932 -QAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDP 4990
Query: 2112 LGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMC----QEFEQNAS 2167
L P+ E LE+ L E R Q + ++ QV + C ++++
Sbjct: 4991 LIKPTGK------EDLEQKVASL----ELRSQRMSRDSGAQVDLLQRCTAQWHDYQKARE 5040
Query: 2168 TFLQWILETRAYFLDGSLLKETGTLESQLEANKRK---------QKEIQAMKRQLTKIVD 2218
++ + +T + SLLK + + E++ + ++ K ++I A++ + +++
Sbjct: 5041 EVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEK 5100
Query: 2219 LGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQI 2260
G+ DA + S + Q+W +L + + LE +
Sbjct: 5101 TGN---DASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5139
Score = 59.7 bits (143), Expect = 3e-08
Identities = 443/2446 (18%), Positives = 903/2446 (36%), Gaps = 409/2446 (16%)
Query: 29 QEVLTRYQSFKERVAERGQKLEDSYHL-QVFKRDADDLGKWI------MEKVNILTDKSY 81
Q++ RY++ +ER E K E L Q ++RD W+ +++ ++L ++
Sbjct: 3474 QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH 3533
Query: 82 EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWD 141
T ++ Q L+ L++ + TRE+ G E+ +E LR W
Sbjct: 3534 THETTLRDL----QELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRA--LESLRQDWQ 3587
Query: 142 LLLELTLEKGDQLLRAL-KFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKF 200
E Q + K + Q+ + EW+ E KK+
Sbjct: 3588 AYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAE------------------EKKW 3629
Query: 201 EDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKAL 260
+ E+ A V EV A E +E+H + + + ++ + ++ L L++ K L
Sbjct: 3630 HE---EVTAYRDEVEEVGARAQEILDESHVNSRM-GCQATQLTSRYQALLLQVLEQIKFL 3685
Query: 261 SNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKV 320
E IQ ++E E L+S S+ +HK +N+A DKV
Sbjct: 3686 E-------------EEIQSLEESESSLSSY--------SDWYGSTHKNF-KNVATKIDKV 3723
Query: 321 KELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWY------HR 374
+ + TL E L+ E +L S EK + Y R
Sbjct: 3724 DTVMMGKKLKTL-------------EVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAER 3770
Query: 375 FSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADE--- 431
+ + + E T+ + + + + + H + D+ ++ +
Sbjct: 3771 LRKEIHDHMEQLKELTSTVRKEHMTLE------------KGLHLAKEFSDKCKALTQWIA 3818
Query: 432 TGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSW 491
Q++++ E E+ EK L +++ +Q + H V S
Sbjct: 3819 EYQEILHVPEEPKMELYEKKAQLS------------KYKSLQQTVLSH-----EPSVKSV 3861
Query: 492 MSRQEAFLENEDLGNSLGSAEALLQKHEDFE----------EAFTAQEEKIITVDKTATK 541
+ EA LE L + + + Q D++ E E+++ +
Sbjct: 3862 REKGEALLE---LVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDT 3918
Query: 542 LIGD--DHYDSENIKAIRDGLLARRDALREKAATRRRLLKE-SLLLQKLYEDSDDLKN-- 596
LIG DH ++ + + L +D+ +T +R+ + LQK D L+
Sbjct: 3919 LIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQ 3978
Query: 597 -WINK---------KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQ-KTGQ 645
W++ + L+ E K +++ ++ +Q+Q +L + L N KT
Sbjct: 3979 AWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRA-LQEQARTYLDLLCSMCDLSNASVKTTA 4037
Query: 646 EMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLED 705
+ I+ + + + WEE+ + L +A+QQLQ +++R +
Sbjct: 4038 KDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQ------NMKRRHSE 4091
Query: 706 VEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILT--DLAAYFEEIGHPDSKD 763
+E + +++V++ ++K +++V ++V+ LT + + +EI H + +
Sbjct: 4092 LELNIAQ----NMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQW 4147
Query: 764 I-RARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLG 822
+ RQ + +C +E R + D +++ + + E W A ST +
Sbjct: 4148 LDLCRQSNNLC---LQREEDLQRTRDYHDCMNVVEVFLEKFTTE-WDNLARSDAESTAV- 4202
Query: 823 KDLIASKKL---LNRHRVILENIASHEPRI--------QEITERGNKMVEEGHFAAEDVA 871
L A KKL L + +E++ + ++ +E+ + +E+ F ED+
Sbjct: 4203 -HLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLI 4261
Query: 872 SR-VKSLNQNMESLRARAARRQNDLEANVQFQQYLAD-LHEAETWIREKEPIVDNTNYGA 929
R ++ N+E L +R Q +E + Q +A+ L ++ + ++D+ +
Sbjct: 4262 KRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICS 4321
Query: 930 DEEAAGALLKK----HEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQR---- 981
+ EA LLK + + DL G + + + +A + Q + + G++R
Sbjct: 4322 ELEAKQMLLKSLIKDADRVMADL---GLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4378
Query: 982 ---------VMALYD--FQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVY 1030
+MA++ Q + M + + L ++K ++A
Sbjct: 4379 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNE 4438
Query: 1031 VRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEER----------RRRLLQ 1080
V L ++ + +E + + +++++ Y S+L + R R+ +
Sbjct: 4439 VTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKE 4498
Query: 1081 RYNEFLLAYEAGDMLEWIQEKKAENTGVEL-------DDVWELQKKFDEFQKDL-NTNEP 1132
+++ + D++ + E N EL ++ E +++ L T +
Sbjct: 4499 DFDKACHWLKQADIVTF-PEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4557
Query: 1133 RLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREA 1192
L +N+V L E L L ++ + LA ++ + A +
Sbjct: 4558 ILPSLNEVDHSYLSEKL---------NALPRQFNVIVALAKDKFYKVQEAILARKEYASL 4608
Query: 1193 DD--TKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLS 1250
+ T+ E + Q L + +DL +AL + +G L D+V LGE + L+
Sbjct: 4609 IELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQ-DGCRAIL----DEVAGLGEAVDELN 4663
Query: 1251 ---ESHPDATEDLQRQKM-ELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWIS 1306
E + Q KM L + L+ +T+ R L + Y K
Sbjct: 4664 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEK--------- 4714
Query: 1307 SIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEI 1366
Q+L L ++ + E E + + +L + L DSG
Sbjct: 4715 ------MCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSL---AGSLQDSG------- 4758
Query: 1367 EKKLQAVKLERDDLEK-----AWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSD 1421
L+ V + +DL A+EK + ++Q +QG + S + S
Sbjct: 4759 -IVLKRVTIHLEDLAPHLDPLAYEKARH------QIQSWQGELKLLTSAIGETVTECESR 4811
Query: 1422 DKSSLDSLEALMKKRDDLDKAITAQEGKI---TDLEHFAESLIADEHYAKEEIATRLQRV 1478
S+D + + D L + G + +L+ E + + + +E +Q
Sbjct: 4812 MVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEE-----VQSS 4866
Query: 1479 LDRWKALKAQLIDERTKLGDY--ANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQR 1536
L AL + ++ TK + A+L+ +L EL+ I E L T
Sbjct: 4867 LRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRT-------------- 4912
Query: 1537 KYLKHQTFAHEVDGRSEQVHGVINLGNSLIECS----ACDGNEEAMKEQLEQLKEHWDHL 1592
Q E+ + ++ + V N +E + GN ++ E LK H +
Sbjct: 4913 ----RQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFF 4968
Query: 1593 LERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLL 1652
S + +F++++ + ++ + L+ + +L + Q +
Sbjct: 4969 --------------STEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRM 5014
Query: 1653 EREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRF--LNVQELAAAH--HEK 1708
R+ A+ D L+ D + +++++ ++ K+ ++ + +++H EK
Sbjct: 5015 SRDSGAQVDLLQRCTAQWHDYQKAR----EEVIELMNDTEKKLSEFSLLKTSSSHEAEEK 5070
Query: 1709 LKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDL------QGVQNLLKKHKRLEGEL 1762
L E AL ++ +EEK ++ + G D + + + ++ RL
Sbjct: 5071 LSEHKALVSVVNSFHEKIVALEEKASQL--EKTGNDASKATLSRSMTTVWQRWTRLRAVA 5128
Query: 1763 VAHEPAIQNVLD--------------MAEKLKDK--AAVGQEEIQLRLAQFVEHWE---- 1802
E +++ +D M ++L+DK + ++ + L +E+ +
Sbjct: 5129 QDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVL 5188
Query: 1803 KLKELAKARGLKLEESLEYLQ--FMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMK 1860
+L++ A G+ +++L LQ EE + E A+ R T L+K
Sbjct: 5189 ELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVK 5248
Query: 1861 HEALENDFA----------VHETR------VQNVCAQGEDILNKVLQEESQNKEISSKIE 1904
E + + V ET+ + AQ E++ + + + + I E
Sbjct: 5249 QELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAE 5308
Query: 1905 ALNEK----------TPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTN 1954
EK SL A A L++ D Q + +V ++ +E S +
Sbjct: 5309 EQKEKYLGLYTILPSELSLQLAEVALDLKIRD----QIQDKIKEVEQSKATSQELSRQIQ 5364
Query: 1955 GNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALL 2014
DL LT L + ++ Q+ E+ KL+ K +E+
Sbjct: 5365 KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGK 5424
Query: 2015 KRWEQLLEASAVHRQKLLEKQLPLQK---AEDLFVEFAHKASALNNWCEKMEENLSEPVH 2071
+++ + + +H+Q + + + L K A E+ + W EK + +
Sbjct: 5425 PLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIA 5484
Query: 2072 CVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTW 2131
S +++R+ H+ L ++ + + E Q + + V + V L R
Sbjct: 5485 WNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTS--VYCTEKMSQQVAELGRET 5542
Query: 2132 KHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETG- 2190
+ L +I+ R Q LQ + A+ +K FE E ++ LQ LE L E G
Sbjct: 5543 EELRQMIKIRLQNLQ-DAAKDMKKFE--AELKK-----LQAALEQAQATLTS---PEVGR 5591
Query: 2191 -TLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLG 2249
+L+ QL + E++++K ++ + L I + +++ L +L +
Sbjct: 5592 LSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALR---IPEDVVASLPLCHAALRLQEEA 5648
Query: 2250 LRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKE 2295
R+QH QQ V E ++ KH + + G H+E
Sbjct: 5649 SRLQHTAIQQCNIMQAAVVQYE---QYEQEMKHLQQLIEG--AHRE 5689
Score = 53.5 bits (127), Expect = 2e-06
Identities = 50/211 (23%), Positives = 94/211 (44%), Gaps = 15/211 (7%)
Query: 63 DDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELE-KTREER--- 118
DD I + NI+ K+ P + Y+ + L E + + LE K +EE
Sbjct: 8295 DDSRFQIQQTENIIRSKTPTGP-ELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 8353
Query: 119 --FTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRAL-KFQQYVQECADILEWIG 175
F HS +T I+ W+LL L K ++ + L K+QQ+ + I W+G
Sbjct: 8354 PGFVNLHSTETQTAGVIDR----WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLG 8409
Query: 176 DKEAIATS---VELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDL 232
D E +EL D + E+ KK ++ Q + ++ ++ +N + E + + +
Sbjct: 8410 DTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKES 8469
Query: 233 PLIQSKQNEVNAAWERLRGLALQRQKALSNA 263
+Q + +++N W+R+ L + + L +A
Sbjct: 8470 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDA 8500
Score = 39.3 bits (90), Expect = 0.047
Identities = 64/329 (19%), Positives = 123/329 (37%), Gaps = 48/329 (14%)
Query: 408 LLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDE 467
L D++Q KH Y+ + + + Q L + D+ ++ +W + +
Sbjct: 351 LQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLDQA-----LVKQSWDRVTSRLFD 405
Query: 468 RHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTA 527
H Q ++ L L + +W+ R E L E + Q HE+
Sbjct: 406 WHIQLDKSLPAPL-----GTIGAWLYRAEVALREEI---------TVQQVHEETANTIQR 451
Query: 528 --QEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKA--------ATRRRL 577
++ K + + A K + Y + ++ +G+ D L + A + L
Sbjct: 452 KLEQHKDLLQNTDAHKRAFHEIYRTRSV----NGIPVPPDQLEDMAERFHFVSSTSELHL 507
Query: 578 LKESLL------LQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELA 631
+K L L L LK+WI K + E +QN S ++ + FE+
Sbjct: 508 MKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQL--LQNYVSFIENSKFFEQY-- 563
Query: 632 VNKTQLENIQKTGQEMI--EGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQ 689
+ + +++T + + +G ++NV ++E + W L + + L E
Sbjct: 564 --EVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISN 621
Query: 690 L-QFENNAEDLQRWLEDVEWQVTSEDYGK 717
++ N LQ WLED E + + K
Sbjct: 622 WDRYGNTVASLQAWLEDAEKMLNQSENAK 650
>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
Length = 3677
Score = 142 bits (359), Expect = 3e-33
Identities = 416/2324 (17%), Positives = 900/2324 (38%), Gaps = 278/2324 (11%)
Query: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDK- 79
A+ I++ +++ +R+ F + ++ER LE ++ F L + N L +
Sbjct: 790 ADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP 849
Query: 80 -SYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTM---GHSAHEETKAHIEE 135
+ +PT I+ + + + EV S L ++E+ + + + G +
Sbjct: 850 TTPSEPTAIKSQLK---ICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAF 906
Query: 136 LRHLWDLLLELTLEKGD--QLLRALKFQQYVQECADILEWIGDKEAIATSVELG-EDWER 192
H + ++ + + + L +Y + + I W+ E + +L D+E
Sbjct: 907 TNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEI 966
Query: 193 TEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPL-IQSKQNEVNAAWERLRG 251
E + + Q L ++ + ++ E +++ ++ QS+ E+ W++L
Sbjct: 967 MEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSS 1026
Query: 252 LALQRQKALSNAAN--------LQRFKRDVTEAIQWIKEKEPVL-TSEDYGKDLVASEGL 302
++ + L N +Q K+ + E ++KE+ P L SE K L L
Sbjct: 1027 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1086
Query: 303 FHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSR 362
+ ++ +L +++ +++ +AE P A +++ ++L + W+H+ +R
Sbjct: 1087 VSDIQTIQPSLNSVNEGGQKIKNEAE------PEFASRLETELKELNTQWDHMCQQVYAR 1140
Query: 363 YEKLQATYWYH-RFSSDFDELSGWMNEKTAAI--------NADELPTDVAGGEVLLDRHQ 413
E L+ D E+ WM + DEL V + + Q
Sbjct: 1141 KEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQ 1200
Query: 414 QHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYE 473
Q + ++ + S + A A + +++++E L N+ L + + + E
Sbjct: 1201 QKEAKVKLLTESVNSV------IAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLE 1254
Query: 474 QCLD-FHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKI 532
+ +H E+ + W++ E L+ + N G AE + + + E E+
Sbjct: 1255 EVWACWHELLSYLEKANKWLNEVEFKLKTTE--NIPGGAEEISEVLDSLENLMRHSEDNP 1312
Query: 533 ITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDS- 591
+ + + + D E I + +R L E+A R++LL++S+ + E S
Sbjct: 1313 NQI-RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1371
Query: 592 ---DDLKNWINKKKK--LADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQE 646
+ +I+K+ +AD D + Q+ Q + +L ++ LE ++K Q
Sbjct: 1372 HLIQESLTFIDKQLAAYIADKVDAAQMP------QEAQKIQSDLTSHEISLEEMKKHNQ- 1424
Query: 647 MIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDV 706
G A+ V LS++ ++L + + + AN FE ++ + L++V
Sbjct: 1425 ----GKEAAQRV---LSQIDVAQKKLQDVSMKFRLFQKPAN----FEQRLQESKMILDEV 1473
Query: 707 EWQVTSEDYGKGLAEV-QNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDS-KDI 764
+ + + + EV Q++L L +++ + +V+++ + ++ K++
Sbjct: 1474 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1533
Query: 765 RARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDE-EAWIQETEPSATS----- 818
R +L + L + RK++L L L R + W+ T+ T
Sbjct: 1534 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1593
Query: 819 ---TYLGKDLI---ASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVAS 872
+ L ++ A++K + + +V L++I ++ + + +VE+
Sbjct: 1594 GMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVED---------- 1643
Query: 873 RVKSLNQNMESLRARAARRQNDL-EANVQFQQYLADLHEAETWIREKEPIVDNTNYGADE 931
++ LN N ++ +RA N L E + + ++ WI + + ++D + +
Sbjct: 1644 KLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQ 1703
Query: 932 EAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQAR 991
+ +LK+ +A +LN + + R+QA + + Q + F A
Sbjct: 1704 QKED-VLKRLKA---ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAI 1759
Query: 992 SPREVTMKKGDVLTLLSSINKDWWKV----EAADHQGI-----------------VPAVY 1030
S R T K L L N D K+ EA QG+
Sbjct: 1760 SHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKEL 1819
Query: 1031 VRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNE-FLLAY 1089
++R + + + +R+REE I +Q+ ++ ++ +L D +RR++ L+ ++ +
Sbjct: 1820 LQRGDNLQQRITDERKREE---IKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKR 1876
Query: 1090 EAGDMLEWIQ--EKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFE 1147
+A D+L+ + EKK + D+ +K E ++L + L + + A+ L +
Sbjct: 1877 QADDLLKCLDDIEKKLASLPEPRDE-----RKIKEIDRELQKKKEELNAVRRQAEGLSED 1931
Query: 1148 GL-LTPEGAQIRQELNSRWGSLQ-RLADEQRQLLGSAHAVE------------------- 1186
G + E QI +L+ RW ++ + A +R H V
Sbjct: 1932 GAAMAVEPTQI--QLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1989
Query: 1187 -VFHREADDTKEQIEKKCQALSAADP-GSDLFSVQALQRRHEGFERDLVPLGDKVTIL-G 1243
+ E + + + Q L+A D D + + + + L ++ I+
Sbjct: 1990 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2049
Query: 1244 ETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEA-QKFYLFLSKARDLQ 1302
+ L + P LQ +L+ WE + KDR+ + + +K+ F +
Sbjct: 2050 KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 2109
Query: 1303 NWISSIGGMVSSQELAEDLTGIEI--LLERHQEHRADMEAEAPTFQALEDFSAELIDSGH 1360
W++ + ++ E+ + L+ Q+ + T A + E+I
Sbjct: 2110 QWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGE---EIIQQSS 2166
Query: 1361 HASPEI-EKKLQAVKLERDDLEKAWEKRKKILDQCLE-LQMFQGNCDQVESWMVARENSL 1418
I ++KL ++ L ++ K RKK L++ L FQ + ++ W+ +N
Sbjct: 2167 KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIA 2226
Query: 1419 RSD-DKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEE---IATR 1474
+ L+ +++ L + + ++G + L ++ + EE + +
Sbjct: 2227 SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK 2286
Query: 1475 LQRVLDRWKALKAQLIDERTKL-GDYANLKQFYRDLEELEEWISEML----PTACDESYK 1529
L++ +W + L +++ ++ +L Q + LE+LEE ++ +L P
Sbjct: 2287 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY 2346
Query: 1530 DATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHW 1589
+ N + + +T V + V +++ G L + + +K +LE L W
Sbjct: 2347 NQPNQEGPFDVQETEI-AVQAKQPDVEEILSKGQHLYKEKPAT---QPVKRKLEDLSSEW 2402
Query: 1590 ---DHLLERTNDKGKKLN---------------------------------------EAS 1607
+ LL+ K L E
Sbjct: 2403 KAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVP 2462
Query: 1608 RQQRFNTSIRDFEFWLSEAETLL-AMKDQARDLASAGNLLKKHQLLEREMLAREDALKDL 1666
FN + + WLS + ++ + + DL ++ K + +++ R L++L
Sbjct: 2463 ALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEEL 2522
Query: 1667 NTLAEDLLSSGTFNVDQ---IVKKKDNVNKRFLNVQELAAAHHEKLKEAYA-LFQFFQDL 1722
T A++L + T N + I + + + ++ VQE ++L E Q+ +
Sbjct: 2523 ITAAQNLKNK-TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2581
Query: 1723 DDEESWIEEKLIRVSSQDYGR-DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL-K 1780
++ E + + ++ S G + +Q + + K+L +L + + D+A KL +
Sbjct: 2582 EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 2641
Query: 1781 DKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQ-FMQNAEEEEAWINEKN 1839
D +A ++ + W + + R LEE+ LQ F + E+ AW+ E
Sbjct: 2642 DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 2701
Query: 1840 ALA-VRGDCG------DTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQE 1892
A V D + + L+ + + L+ + H N+ + IL L+
Sbjct: 2702 TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS-LEG 2760
Query: 1893 ESQNKEISSKIEALNEKTPSLAKAIAAWKLQLE-DDYAFQEFNWKADVVEAWIADKETSL 1951
+ +++ +N K L K + LE ++ + + W+ K+ L
Sbjct: 2761 SDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2820
Query: 1952 KTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEI-TDLKDKLISAQHNQSKAIEERY 2010
A +G + KQ+ + + + + + P I + L+ I + +E+ Y
Sbjct: 2821 SRQ---APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLY 2877
Query: 2011 ---------------AALLKR--------WEQLLEASAVHRQKL---LEKQLPLQKAED- 2043
LL++ WE+L SA ++K+ LE+ LQ+A D
Sbjct: 2878 QEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDE 2937
Query: 2044 LFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLL 2103
L ++ +W +PV + ++ ++ + + +A + + +
Sbjct: 2938 LDLKLRQAEVIKGSW---------QPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVN 2988
Query: 2104 ELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQK 2147
+L +Q+ LG+ SPY T+E L WK L +E+R ++L +
Sbjct: 2989 DLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHE 3032
Score = 142 bits (357), Expect = 5e-33
Identities = 440/2382 (18%), Positives = 893/2382 (37%), Gaps = 346/2382 (14%)
Query: 68 WIMEK---VNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTM--G 122
W+ EK VN + ++D + QK L+A+++ K + M +L +++ +
Sbjct: 566 WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 625
Query: 123 HSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIAT 182
S ++T+A ++ WD L++ + Q+ +A+ Q ++E + T
Sbjct: 626 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETV-------T 678
Query: 183 SVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEV 242
+V R ++L K A+E P P + +Q V
Sbjct: 679 TVTT-----REQILVKH-------------------------AQEELPPPPPQKKRQITV 708
Query: 243 NAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGL 302
++ + R D+TE WI E VL S ++ + EG
Sbjct: 709 DSEIRK-------------------RLDVDITELHSWITRSEAVLQSPEFA--IFRKEGN 747
Query: 303 FHSHK----GLERNLAVMSDKVKELCAKAEKLT---LSHPSDAPQIQEMKEDLVSSWEHI 355
F K +ER A K+++ A+ L ++ +A I++ E L S W
Sbjct: 748 FSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEF 807
Query: 356 RALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADEL-PTDVAGGEVLLDRHQQ 414
L + R L+ + + + +++L T A N ++ PT + + + +
Sbjct: 808 CQLLSERLNWLE---YQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKI 864
Query: 415 HKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDE------- 467
K E++ S + + + A E + LD ++ A + +
Sbjct: 865 CKDEVNRL-----SGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQA 919
Query: 468 RHRQYEQCLDF--HLFYRDS-EQVDSWMSRQEAFL--------ENEDLGNSLGSAEALLQ 516
R ++ + D + Y+++ + +W+ + E L + E + LG +AL
Sbjct: 920 REKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQS 979
Query: 517 KHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRR 576
++ + + + K A I Y SE + + R L + +
Sbjct: 980 SLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEF-----EEIEGRWKKLSSQLVEHCQ 1033
Query: 577 LLKESL-LLQKLYEDSDDLKNWINKKKKLADDE--DYKDIQNLKSRVQKQQVFEKELAVN 633
L+E + L+K+ LK W+ + +E D + LK ++++ ++ ++
Sbjct: 1034 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1093
Query: 634 KTQLENIQKTGQEMI-EGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQ-LQ 691
+ L ++ + GQ++ E + + T L E+ + W+ + + + L ++ +
Sbjct: 1094 QPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVS 1153
Query: 692 FENNAEDLQRWLEDVEWQVTSEDYG-KGLAEVQNRLRKHGLLESAVAARQDQVDILTDLA 750
+ + ++ W+ E + D+ K E+Q + + + ++ +V +LT+
Sbjct: 1154 LQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESV 1213
Query: 751 AYFEEIGHPDSKD-IRARQESLVCRFEALKEPLATRKKKLLDLLHL-QLICRDTEDEEAW 808
P +++ ++ E+L ++ L L + K L ++ + E W
Sbjct: 1214 NSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKW 1273
Query: 809 IQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAE 868
+ E E +T +++ + ++ LEN+ H + + +G E
Sbjct: 1274 LNEVEFKLKTT---ENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDE 1330
Query: 869 DVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDN--TN 926
+ +++ N L A RRQ LE ++Q Q + ++ I+E +D
Sbjct: 1331 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQ---ETEKSLHLIQESLTFIDKQLAA 1387
Query: 927 YGADEEAAGALLKKHEAFLLDLNSFGDSMKALR--NQANACQQQQAAPVEGVAGEQRVMA 984
Y AD+ A + ++ + DL S S++ ++ NQ Q+ + ++ + + ++
Sbjct: 1388 YIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVS 1447
Query: 985 LYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAH-------- 1036
+ + P + + +L + + A + + + V +L H
Sbjct: 1448 MKFRLFQKPANFEQRLQESKMILDEVKMH---LPALETKSVEQEVVQSQLNHCVNLYKSL 1504
Query: 1037 ----DEFPML--------PQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRL------ 1078
E M+ +++ E P + +R ++ Y L + ER+++L
Sbjct: 1505 SEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKL 1564
Query: 1079 ---LQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLR 1135
+++ L + A +E + E LD K QK++ + L+
Sbjct: 1565 SRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKAT---QKEIEKQKVHLK 1621
Query: 1136 DINKVADDLLFEGLLTPEGAQIRQEL---NSRWGSLQRLADEQRQLLGSAHA-VEVFHRE 1191
I +V + L + +L + + +L NS W ++ A+E LL +E F +
Sbjct: 1622 SITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 1679
Query: 1192 ADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSE 1251
D + I + L ++ L+R + +L + KV + A L
Sbjct: 1680 VDHITKWIIQADTLLDESEKKKPQQKEDVLKR----LKAELNDIRPKVDSTRDQAANLMA 1735
Query: 1252 SHPDATEDL-QRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGG 1310
+ D L + Q ELN + + R K K S+ ++L+ + S I
Sbjct: 1736 NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI-----------PLKELEQFNSDIQK 1784
Query: 1311 MVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEI--EK 1368
++ E AE G+ + + ++ DM + E EL+ G + I E+
Sbjct: 1785 LLEPLE-AEIQQGVNL---KEEDFNKDMNEDN------EGTVKELLQRGDNLQQRITDER 1834
Query: 1369 KLQAVKLERDDLEKAW--------EKRKKILDQCLELQMFQGNCDQVESWMVARENSLRS 1420
K + +K+++ L+ ++RKK L+ + ++ D + + E L S
Sbjct: 1835 KREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLAS 1894
Query: 1421 -----DDKSSLDSLEALMKKRDDLDKAITAQEGKITD----------------------- 1452
D++ + L KK+++L+ EG D
Sbjct: 1895 LPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESK 1954
Query: 1453 LEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEEL 1512
F A H +EE V+ L+ + T L + ++ Q ++E+L
Sbjct: 1955 FAQFRRLNFAQIHTVREET----MMVMTEDMPLEISYVPS-TYLTEITHVSQALLEVEQL 2009
Query: 1513 EEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACD 1572
P C + ++D + + + GR + +H SA
Sbjct: 2010 LN-----APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ----SATP 2060
Query: 1573 GNEEAMKEQLEQLKEHWDHLLERTNDK-GKKLNEASRQQRFNTSIRDFEFWLSEAETLLA 1631
++E L QL W+ + + D+ G+ + +RF+ I+ F WL+EAE L
Sbjct: 2061 VERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLR 2120
Query: 1632 MKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK-DN 1690
K Q + + L+ + R+ ++ LN E+++ + I+++K +
Sbjct: 2121 -KTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2179
Query: 1691 VNKRFLNVQELAAAHHEKLKEAYALFQFFQ-DLDDEESWIEEK-------LIRVSSQDYG 1742
+N R+ V + + ++L+E + FQ DL++ W+EE L Q
Sbjct: 2180 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLK 2239
Query: 1743 RDLQGV----------QNLLKKHKRLEGELVAHEPAIQNVLDMAE-KLKDK--------- 1782
L+ V Q +LK+ G ++ P D E KLK
Sbjct: 2240 EKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSR 2299
Query: 1783 ---AAVGQEEIQLR-LAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEK 1838
G+ E Q++ L Q + E L+E L L L+ +E + ++
Sbjct: 2300 ALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQE 2359
Query: 1839 NALAVRG---DCGDTLA----------ATQSLLMKHEALENDFAVHETRVQNVCAQGEDI 1885
+AV+ D + L+ ATQ + K E L +++ +Q + A+ D+
Sbjct: 2360 TEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDL 2419
Query: 1886 LNKVLQ-EESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWI 1944
+ S + ++ + + K +++K L LE A +FN + W+
Sbjct: 2420 APGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVP-ALADFNRAWTELTDWL 2478
Query: 1945 ADKETSLKTNG-NGADLGDFLTLLAKQDTLDASLQSFQQER--LPEITDLKDKLISAQHN 2001
+ + +K+ DL D ++ KQ A++Q +Q R L E+ L + N
Sbjct: 2479 SLLDQVIKSQRVMVGDLEDINEMIIKQK---ATMQDLEQRRPQLEELITAAQNLKNKTSN 2535
Query: 2002 QSKA--IEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWC 2059
Q I +R + +W+++ E RQ+L E + K ++E +A +
Sbjct: 2536 QEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE----MLKDSTQWLEAKEEAEQVLGQA 2591
Query: 2060 EKMEENLSEPVHCVS-----LNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGV 2114
E+ E + V + E +QL KD + ++ A D +K L
Sbjct: 2592 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAN---------DLALKLLRD 2642
Query: 2115 PSSPYT---WLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQ 2171
S+ T + E + +W+ + + ERE L++ + Q+F + FL
Sbjct: 2643 YSADDTRKVHMITENINASWRSIHKRVSEREAALEETH-------RLLQQFPLDLEKFLA 2695
Query: 2172 WI--LETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL------ 2223
W+ ET A L + KE L + K K+ Q ++ ++ D+ NL
Sbjct: 2696 WLTEAETTANVLQDATRKE--RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQK 2753
Query: 2224 --------EDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLE 2257
+DA++L + + +W +L + L ++ +LE
Sbjct: 2754 ILRSLEGSDDAVLLQRRLDNMNF--KWSELRKKSLNIRSHLE 2793
Score = 131 bits (330), Expect = 7e-30
Identities = 300/1619 (18%), Positives = 628/1619 (38%), Gaps = 149/1619 (9%)
Query: 673 LEATKQK--GTQLHEANQQL-QFENNAEDLQRWLEDVEWQVTSE-DYGKGLAEVQNRLRK 728
LEA + K G+ L E+ L +++ E++ WL E + ++ + + V+++
Sbjct: 314 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT 373
Query: 729 HGLLESAVAARQDQVDILTDLAAYF---EEIGHPDSKDIRARQESLVCRFEALKEPLATR 785
H + A Q +V + L + ++ + +++ + L R+E L+ +
Sbjct: 374 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 433
Query: 786 KKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY---LGKDLIASKKLLNRHRVILENI 842
+ L +L + L + ++ W+ +TE LG DL K+ + +H+V+ E++
Sbjct: 434 QSNLHRVL-MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDL 492
Query: 843 ASHEPRIQEITERGNKMVE-EGHFAAEDVASRVKSLNQNMESLRARAARRQNDL-EANVQ 900
+ R+ +T + E G A + ++K L ++ R L + ++
Sbjct: 493 EQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLK 552
Query: 901 FQQYLADLHEAETWIREKEPIVD--NTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKAL 958
+Q+ + W+ EKE V+ +T D+ + L+K DL SM L
Sbjct: 553 WQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 612
Query: 959 RNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMK-KGDVLTLLSSINKDWWKV 1017
+ +Q + ++ + Q+ A D AR + K + + ++ +
Sbjct: 613 ----YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 668
Query: 1018 EAADHQGIVPAVYVR-----RLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAE 1072
V V R + A +E P P +++ RQ ++++ R LD
Sbjct: 669 TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKK--------RQITVDSEIRKRLD--- 717
Query: 1073 ERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVEL------DDVWELQKKFDEFQKD 1126
+ ++ WI +A E + +L++K + +++
Sbjct: 718 ----------------VDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIERE 761
Query: 1127 LNTNEPRLRDINKVA----DDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSA 1182
+L+D ++ A + ++ EG+ Q ++LNSRW +L E+ L
Sbjct: 762 KAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQ 821
Query: 1183 HAVEVFHREADDTKEQIEK-----KCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGD 1237
+ + F+ + ++ K Q + ++P + + S + + L P +
Sbjct: 822 NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP-TAIKSQLKICKDEVNRLSGLQPQIE 880
Query: 1238 KVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSK 1297
++ I + + D + + D+Q R K+ +++ + +
Sbjct: 881 RLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKE-LQTIFDTLPPMRYQET 939
Query: 1298 ARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELID 1357
++ W+ +S +L+ +T EI+ +R E +A + L S + +
Sbjct: 940 MSAIRTWVQQSETKLSIPQLS--VTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE 997
Query: 1358 SGHHASPEIEKKLQAVKLERDDLEKAWEKR--------KKILDQCLELQMFQGNCDQVES 1409
A EI +K Q+ E +++E W+K +K+ +Q +L+ Q + ++
Sbjct: 998 MSKKAPSEISRKYQS---EFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKK 1054
Query: 1410 WMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKE 1469
WM A + ++ +L E L K+ ++ + L E ++ A+
Sbjct: 1055 WM-AEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEP 1113
Query: 1470 EIATRLQRVL----DRWKALKAQLIDERTKL-GDYANLKQFYRDLEELEEWISEMLPTAC 1524
E A+RL+ L +W + Q+ + L G +DL E+ EW+++
Sbjct: 1114 EFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYL 1173
Query: 1525 --DESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQL 1582
D YK +Q+ + + E + +V + NS+I A +EA+K++L
Sbjct: 1174 ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVI-AQAPPVAQEALKKEL 1232
Query: 1583 EQLKEHWDHLLERTNDKGKKLNEA--------SRQQRFNTSIRDFEFWLSEAETLLAMKD 1634
E L ++ L R N K K L E S ++ N + + EF L E + +
Sbjct: 1233 ETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE 1292
Query: 1635 QARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK-DNVNK 1693
+ ++ + LE M ED + LA+ L G +D+++ ++ + N
Sbjct: 1293 EISEVLDS---------LENLMRHSEDNPNQIRILAQTLTDGGV--MDELINEELETFNS 1341
Query: 1694 RFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQ--DYGRDLQGVQNL 1751
R+ + E A + L+++ Q Q+ + I+E L + Q Y D +
Sbjct: 1342 RWRELHEEAVRRQKLLEQS---IQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQM 1398
Query: 1752 LKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKAR 1811
++ ++++ +L +HE +++ + K G+E Q L+Q +KL++++
Sbjct: 1399 PQEAQKIQSDLTSHEISLEEM--------KKHNQGKEAAQRVLSQIDVAQKKLQDVS--- 1447
Query: 1812 GLKLEESLEYLQFMQNAEEEEAWINE-KNALAVRGDCGDTLAATQSLLMKHEALENDFAV 1870
+K + F Q +E + ++E K L QS L L +
Sbjct: 1448 -MKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSE 1506
Query: 1871 HETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAF 1930
++ V+ V G I+ K ++ KE+ ++ AL L + K QLE
Sbjct: 1507 VKSEVEMVIKTGRQIVQK--KQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKL 1564
Query: 1931 -QEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEIT 1989
++ + +V+ W+A + L + L Q+ L IT
Sbjct: 1565 SRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSIT 1624
Query: 1990 DLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE---DLFV 2046
++ + L + + +E++ + L W + + LLE Q ++ + D
Sbjct: 1625 EVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1684
Query: 2047 EFAHKASALNNWCEKMEENLSEPV---HCVSLNEIRQLQKDHEDFLASLARAQADFKCLL 2103
++ +A L + EK + E V LN+IR D A+L + D C
Sbjct: 1685 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGD-HCRK 1743
Query: 2104 ELDQQIKALGVPSSPYTW--------LTVEVLERTWKHLSDIIEEREQELQKEEARQVKN 2155
++ QI L + + + ++ LE+ + ++E E E+Q+ + ++
Sbjct: 1744 LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEED 1803
Query: 2156 F--EMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQ 2212
F +M ++ E LQ + D +E + L+ K++++ +R+
Sbjct: 1804 FNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRK 1862
Score = 130 bits (327), Expect = 2e-29
Identities = 396/2157 (18%), Positives = 827/2157 (38%), Gaps = 335/2157 (15%)
Query: 8 TVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYH-LQVFKRDADDLG 66
TV E S E + + Q +E+ R++ ++ E QKLE+ + L+ + L
Sbjct: 994 TVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLK 1053
Query: 67 KWIMEKVNILTDK--SYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHS 124
KW+ E L ++ + D ++ + ++ + L +++QT + L E + +
Sbjct: 1054 KWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQT---IQPSLNSVNEGGQKIKNE 1110
Query: 125 AHEETKAHIE----ELRHLWDLLLELTLEKGDQLLRALKFQQYVQ-ECADILEWIGDKEA 179
A E + +E EL WD + + + + L L+ +Q + +++ EW+ E
Sbjct: 1111 AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE 1170
Query: 180 IATSVELGEDWERTEVLHKKFEDFQ---VELVAKEGRVVEVNQYANECAEENHPDLPLIQ 236
+E +++ + L K E+ + E KE +V + + N + P
Sbjct: 1171 --EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEAL 1228
Query: 237 SKQNEV---NAAW--ERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVL-TSE 290
K+ E N W RL G ++ + L + + +A +W+ E E L T+E
Sbjct: 1229 KKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY---LEKANKWLNEVEFKLKTTE 1285
Query: 291 DYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVS 350
+ +E + LE + D ++ A+ LT D I E E S
Sbjct: 1286 NIPG---GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDE-LINEELETFNS 1341
Query: 351 SWEHIRALATSRY----EKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGE 406
W + A R + +Q+ + E +++++ AA AD++ E
Sbjct: 1342 RWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE 1401
Query: 407 VLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWD 466
+ HEI S +E + N EA+ V ++++ L+
Sbjct: 1402 AQKIQSDLTSHEI--------SLEEMKKH--NQGKEAAQRVLSQIDVAQKK----LQDVS 1447
Query: 467 ERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFT 526
+ R +++ +F ++S+ + + LE + + + ++ L + ++ +
Sbjct: 1448 MKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEV--VQSQLNHCVNLYKSLS 1505
Query: 527 AQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARR---DALREKAATRRRLLKESLL 583
+ ++ V KT +++ +EN K + + + A + + L K R++ L++ L
Sbjct: 1506 EVKSEVEMVIKTGRQIV--QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK 1563
Query: 584 L-QKLYEDSDDLKNWINKKK-KLADDEDYKDI-QNLKSRVQKQQVFEKELAVNKTQLENI 640
L +K+ ++ + L W+ +L + + NL S V + +KE+ K L++I
Sbjct: 1564 LSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI 1623
Query: 641 QKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FENNAEDL 699
+ G+ + V +LS + S W + ++ L E + ++ F+ N + +
Sbjct: 1624 TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHI 1683
Query: 700 QRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAA-YFEEIGH 758
+W+ + + E K + ++ L++ L++ + + +VD D AA G
Sbjct: 1684 TKWIIQAD-TLLDESEKKKPQQKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGD 1739
Query: 759 PDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQET-EPSAT 817
K + + L RF A+ + T K + ++ E + IQ+ EP
Sbjct: 1740 HCRKLVEPQISELNHRFAAISHRIKTGKASIP--------LKELEQFNSDIQKLLEPLEA 1791
Query: 818 STYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEE--GHFAAEDVASRVK 875
G +L ++ N+ + +E ++E+ +RG+ + + E++ + +
Sbjct: 1792 EIQQGVNL--KEEDFNK-----DMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQ 1844
Query: 876 SLNQNMESLR-ARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAA 934
L +L+ R+ RR+ LE + Q+ QY + + + E + + DE
Sbjct: 1845 LLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDE--- 1901
Query: 935 GALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQA------------------------ 970
+K + +L + + A+R QA + A
Sbjct: 1902 ----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQ 1957
Query: 971 ------APVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVE------ 1018
A + V E ++ D P E++ LT ++ +++ +VE
Sbjct: 1958 FRRLNFAQIHTVREETMMVMTEDM----PLEISYVPSTYLTEITHVSQALLEVEQLLNAP 2013
Query: 1019 ---AADHQ--------------------GIVPAVYVRRLA--HDEFPMLPQRRREEPGNI 1053
A D + G + ++ ++ A P+ + +E +
Sbjct: 2014 DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL 2073
Query: 1054 TQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDV 1113
+ E++ Y+ R + R ++++ F Y+ +W+ E + ++ +
Sbjct: 2074 DFQWEKVNKMYKDRQGRFD----RSVEKWRRF--HYDIKIFNQWLTEAEQFLRKTQIPEN 2127
Query: 1114 WELQKK---FDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE----LNSRWG 1166
WE K E Q + + +R +N ++++ + T A I QE LN RW
Sbjct: 2128 WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD--ASILQEKLGSLNLRWQ 2185
Query: 1167 SL-QRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAA-DPGSDLFSVQALQR- 1223
+ ++L+D +++L + + F R+ ++ +E+ S +PG + + L++
Sbjct: 2186 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQV 2245
Query: 1224 --------RHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQ 1275
+G + L G V + + + + + Q ++++ A + Q
Sbjct: 2246 KLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ 2305
Query: 1276 GRTKDRKESLNEAQKFYLFLSKARDLQN-------WISSIGGMVSSQELAEDLTGIEILL 1328
G + + + L + +K K DL+ W+S I +EI
Sbjct: 2306 GEIEAQIKDLGQLEK------KLEDLEEQLNHLLLWLSPIRNQ------------LEIYN 2347
Query: 1329 ERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRK 1388
+ +QE D++ QA + E++ G H E + Q VK + +DL W+
Sbjct: 2348 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE-KPATQPVKRKLEDLSSEWKAVN 2406
Query: 1389 KILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEG 1448
++L + L K+ DL +T
Sbjct: 2407 RLLQE--------------------------------------LRAKQPDLAPGLTTIGA 2428
Query: 1449 KITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRD 1508
T +L+ KE ++L+ + + L+ E L D F R
Sbjct: 2429 SPTQ----TVTLVTQPVVTKETAISKLE--------MPSSLMLEVPALAD------FNRA 2470
Query: 1509 LEELEEWISEMLPTACDESYK--DATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLI 1566
EL +W+S + + D +I +K + +++ R Q+ +I +L
Sbjct: 2471 WTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLK 2530
Query: 1567 ECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEA 1626
++ + +++E+++ WD + E +R+Q+ N ++D WL
Sbjct: 2531 NKTSNQEARTIITDRIERIQNQWDEVQEHLQ---------NRRQQLNEMLKDSTQWLEAK 2581
Query: 1627 ETLLAMKDQARDLASAG-------NLLKKHQLLEREMLARE--------DALKDLN-TLA 1670
E + QAR + + ++K ++ E + LA++ D DL L
Sbjct: 2582 EEAEQVLGQARAKLESWKEGPYTVDAIQK-KITETKQLAKDLRQWQTNVDVANDLALKLL 2640
Query: 1671 EDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQ-DLDDEESWI 1729
D + T V I +N+N + ++ + + L+E + L Q F DL+ +W+
Sbjct: 2641 RDYSADDTRKVHMIT---ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL 2697
Query: 1730 EEKLIRVS-SQDYGR------DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDK 1782
E + QD R D +GV+ L+K+ + L+GE+ AH N+ + ++K+ +
Sbjct: 2698 TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL-R 2756
Query: 1783 AAVGQEE---IQLRLAQFVEHWEKLKELAKARGLKLEESL-EYLQFMQNAEEEEAWINEK 1838
+ G ++ +Q RL W +L++ + LE S ++ + + +E W+ K
Sbjct: 2757 SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 2816
Query: 1839 -NALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQN--------VCAQGEDILNKV 1889
+ L+ + G A Q H A + + E + + + Q + L K+
Sbjct: 2817 DDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKL 2876
Query: 1890 LQE----------ESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDY-AFQEFNWKAD 1938
QE ++ + + + E +N + L A W+ ++++ QE D
Sbjct: 2877 YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 2936
Query: 1939 VVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKL 1995
++ + E G+ +GD L D+L L+ + R EI LK+ +
Sbjct: 2937 ELDLKLRQAEV---IKGSWQPVGDLLI-----DSLQDHLEKVKALR-GEIAPLKENV 2984
Score = 128 bits (321), Expect = 8e-29
Identities = 407/2123 (19%), Positives = 796/2123 (37%), Gaps = 386/2123 (18%)
Query: 5 PKETVVESSGPKVLETAE-----EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQV-F 58
P V G K+ AE ++ +E+ T++ ++V R + L+ V
Sbjct: 1095 PSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSL 1154
Query: 59 KRDADDLGKWIM--EKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKS---RLMSE--- 110
++D ++ +W+ E+ + D Y+ P +Q ++ + + E Q K +L++E
Sbjct: 1155 QKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVN 1214
Query: 111 -------------LEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELT--LEKGDQLL 155
L+K E T + L +W EL LEK ++ L
Sbjct: 1215 SVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWL 1274
Query: 156 RALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAK---EG 212
++F+ E G E I+ ++ E+ R H + Q+ ++A+ +G
Sbjct: 1275 NEVEFKLKTTENIP-----GGAEEISEVLDSLENLMR----HSEDNPNQIRILAQTLTDG 1325
Query: 213 RVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRD 272
V++ LI + N+ W L A++RQK L
Sbjct: 1326 GVMD----------------ELINEELETFNSRWRELHEEAVRRQKLLE----------- 1358
Query: 273 VTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKV--KELCAKAEKL 330
++IQ +E E L + E L K L A ++DKV ++ +A+K+
Sbjct: 1359 --QSIQSAQETEKSLH--------LIQESLTFIDKQL---AAYIADKVDAAQMPQEAQKI 1405
Query: 331 TLSHPSDAPQIQEMKEDLVSSWEHIRAL-----ATSRYEKLQATYWYHRFSSDFDE--LS 383
S ++EMK+ R L A + + + + + ++F++
Sbjct: 1406 QSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQE 1465
Query: 384 GWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADE------TGQDLV 437
M ++ L T EV+ Q H ++ Y + E TG+ +V
Sbjct: 1466 SKMILDEVKMHLPALETKSVEQEVV---QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV 1522
Query: 438 NANH-EASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQE 496
E E+ E++ L ++ L ER +Q E+CL S ++ M+
Sbjct: 1523 QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKL------SRKMRKEMNVLT 1576
Query: 497 AFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAI 556
+L D+ + SA + + D E A+ +K I K K I + + +
Sbjct: 1577 EWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK 1636
Query: 557 RDGLLARRDALREK---AATRRR------LLKESLLLQKLYEDSDDLKNWINKKKKLADD 607
++ L+ + +L A T R LL+ ++ ++ D + WI + L D+
Sbjct: 1637 KETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDE 1696
Query: 608 EDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQE----MIEGGHYASDNVTTRLS 663
+ K Q QK+ V ++ A + T + M G + V ++S
Sbjct: 1697 SEKKKPQ------QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQIS 1750
Query: 664 EVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQV------TSEDYGK 717
E+ + + K + + E D+Q+ LE +E ++ ED+ K
Sbjct: 1751 ELNHRFAAISHRIKTGKASI----PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK 1806
Query: 718 GLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEA 777
+ E G ++ + + +TD ++I+ +Q+ L + A
Sbjct: 1807 DMNE-----DNEGTVKELLQRGDNLQQRITD---------ERKREEIKIKQQLLQTKHNA 1852
Query: 778 LKEPLATRKKKLLDLLH-LQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHR 836
LK+ + R+KK L++ H R +D + + E S +D K++
Sbjct: 1853 LKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI----- 1907
Query: 837 VILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE 896
+ +Q+ E N + + +ED A+ +E + + ++R ++E
Sbjct: 1908 ---------DRELQKKKEELNAVRRQAEGLSEDGAAMA------VEPTQIQLSKRWREIE 1952
Query: 897 AN-VQFQQY-LADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDS 954
+ QF++ A +H +RE+ +V E+ + +L ++ +
Sbjct: 1953 SKFAQFRRLNFAQIHT----VREETMMV------MTEDMPLEISYVPSTYLTEITHVSQA 2002
Query: 955 MKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDW 1014
+ + NA + DF+ +E ++K
Sbjct: 2003 LLEVEQLLNAPD----------------LCAKDFEDLFKQEESLKN-------------- 2032
Query: 1015 WKVEAADHQGIVPAVYVRRLA--HDEFPMLPQRRREEPGNITQRQEQIENQYR---SLLD 1069
K G + ++ ++ A P+ + +E + + E++ Y+ D
Sbjct: 2033 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2092
Query: 1070 RAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQK---KFDEFQKD 1126
R+ E+ RR Y+ +W+ E + ++ + WE K E Q
Sbjct: 2093 RSVEKWRR---------FHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDG 2143
Query: 1127 LNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE----LNSRWGSL-QRLADEQRQLLGS 1181
+ + +R +N ++++ + T A I QE LN RW + ++L+D +++L
Sbjct: 2144 IGQRQTVVRTLNATGEEIIQQSSKT--DASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQ 2201
Query: 1182 AHAVEVFHREADDTKEQIEKKCQALS-AADPGSDLFSVQALQR---------RHEGFERD 1231
+ + F R+ ++ +E+ S +PG + + L++ +G +
Sbjct: 2202 KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQ 2261
Query: 1232 LVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKF 1291
L G V + + + + + Q ++++ A + QG + + + L + +K
Sbjct: 2262 LNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEK- 2320
Query: 1292 YLFLSKARDLQN-------WISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPT 1344
K DL+ W+S I +EI + +QE D++
Sbjct: 2321 -----KLEDLEEQLNHLLLWLSPIRNQ------------LEIYNQPNQEGPFDVQETEIA 2363
Query: 1345 FQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQ--MFQG 1402
QA + E++ G H E + Q VK + +DL W+ ++L + Q + G
Sbjct: 2364 VQAKQPDVEEILSKGQHLYKE-KPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPG 2422
Query: 1403 ----------NCDQVESWMVARENSLRSDDKSS----------------------LDSLE 1430
V +V +E ++ + S L L+
Sbjct: 2423 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD 2482
Query: 1431 ALMKKR-------DDLDKAITAQEGKITDLEH---FAESLI---------ADEHYAKEEI 1471
++K + +D+++ I Q+ + DLE E LI A+ I
Sbjct: 2483 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII 2542
Query: 1472 ATRLQRVLDRWKALKAQLIDERTKLGD-YANLKQFYRDLEELEEWISEMLPTACDESYKD 1530
R++R+ ++W ++ L + R +L + + Q+ EE E+ + + A ES+K+
Sbjct: 2543 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQ--ARAKLESWKE 2600
Query: 1531 ----ATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLK 1586
IQ+K + + A ++ V +L L+ + D + + E +
Sbjct: 2601 GPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRK-VHMITENIN 2659
Query: 1587 EHWDHLLERTNDKGKKLNEASR-QQRFNTSIRDFEFWLSEAETLL-AMKDQAR------D 1638
W + +R +++ L E R Q+F + F WL+EAET ++D R D
Sbjct: 2660 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLED 2719
Query: 1639 LASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSS--GTFNVDQIVKKKDNVN---- 1692
L+K+ Q L+ E+ A D +L+ ++ +L S G+ + + ++ DN+N
Sbjct: 2720 SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWS 2779
Query: 1693 ---KRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQ-DYGRDLQGV 1748
K+ LN++ A ++ K + L + W++ K +S Q G D V
Sbjct: 2780 ELRKKSLNIRSHLEASSDQWKRLHL------SLQELLVWLQLKDDELSRQAPIGGDFPAV 2833
Query: 1749 QNLLKKHKRLEGELVAHEPAIQNVLDMA------------EKL---------KDKAAVGQ 1787
Q H+ + EL EP I + L+ EKL +++A
Sbjct: 2834 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 2893
Query: 1788 EEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGD- 1846
++ + + WEKL + K++E+LE LQ +Q A +E + + A ++G
Sbjct: 2894 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA-TDELDLKLRQAEVIKGSW 2952
Query: 1847 --CGDTLA-ATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKI 1903
GD L + Q L K +AL + A + V +V + +Q N S +
Sbjct: 2953 QPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN---LSTL 3009
Query: 1904 EALNEKTPSLAKAIAAWKLQLED 1926
E LN + L A+ QL +
Sbjct: 3010 EDLNTRWKLLQVAVEDRVRQLHE 3032
Score = 115 bits (287), Expect = 7e-25
Identities = 385/2188 (17%), Positives = 838/2188 (38%), Gaps = 305/2188 (13%)
Query: 260 LSNAANLQRFKRDVTEAIQWIKEKEPVLTSE-DYGKDLVASEGLFHSHKGLERNLAVMSD 318
+ + NL R++ + E + W+ E L ++ + D+ + FH+H+G +L
Sbjct: 327 MESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQG 386
Query: 319 KVKELCAKAEKL----TLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHR 374
+V + KL LS + ++QE L S WE +R + + L HR
Sbjct: 387 RVGNILQLGSKLIGTGKLSEDEET-EVQEQMNLLNSRWECLRVASMEKQSNL------HR 439
Query: 375 FSSDFD-----ELSGW----------MNEKTAAINADELPTDVAGGEVLLDRHQQHKHEI 419
D EL+ W M E+ + ++L V +VL + +Q + +
Sbjct: 440 VLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 499
Query: 420 DSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQ-CLDF 478
+S DE+ D A+ + E++++L + W + ++R + L +
Sbjct: 500 NSLTHMVVVVDESSGD------HATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKW 553
Query: 479 HLFYRDSEQVDSWMSRQE---------AFLENEDLGNSLGSAEALL----QKHEDFEEAF 525
+ +W+S +E F + ++ +SL L +K + + +
Sbjct: 554 QRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLY 613
Query: 526 TAQEEKIITV--------------------DKTATKLIGDDHYDSENIKAIRDGL----- 560
+ +++ + T+ D KL S+ + + L
Sbjct: 614 SLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTV 673
Query: 561 ------LARRDALREKAA----------TRRRLLKESLLLQKLYEDSDDLKNWINKKKKL 604
+ R+ + K A +R++ +S + ++L D +L +WI + + +
Sbjct: 674 METVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAV 733
Query: 605 ADDEDYKDIQ---NLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIE---GGHYASDNV 658
++ + N +K E+E A +L++ ++ Q ++E +D++
Sbjct: 734 LQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSI 793
Query: 659 TTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVE-WQVTSEDYGK 717
++ S W E + ++ L N + F N + L++ E W
Sbjct: 794 KQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 853
Query: 718 GLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEA 777
++++L+ + ++ Q Q++ L + +E G + A + F+
Sbjct: 854 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQ-GPMFLDADFVAFTNHFKQ 912
Query: 778 LKEPLATRKKKLLDLLHLQLICRDTEDEEA---WIQETEPSATSTYLG-KDLIASKKLLN 833
+ + R+K+L + R E A W+Q++E + L D ++ L
Sbjct: 913 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 972
Query: 834 RHRVILENIASHE-------PRIQEITERGNKMVEEGHFAA-EDVASRVKSLNQNMESLR 885
+ + ++ + ++E++++ + + + E++ R K L+ +
Sbjct: 973 ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHC 1032
Query: 886 ARAARRQNDLEANVQFQQYLAD-LHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAF 944
+ + N L Q L + E + +++E+ P + D E LK+
Sbjct: 1033 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPAL------GDSEILKKQLKQCRLL 1086
Query: 945 LLDLNSFGDSMKALRNQA----NACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKK 1000
+ D+ + S+ ++ N + + A+ +E E + Q R+ +K
Sbjct: 1087 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1146
Query: 1001 GDVLTLLSSINKDW-----WKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQ 1055
G L S+ KD W +A + Y+ R + P Q+ EE +
Sbjct: 1147 G--LEKTVSLQKDLSEMHEWMTQAEEE-------YLERDFEYKTPDELQKAVEEMKRAKE 1197
Query: 1056 RQEQIENQYR-------SLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGV 1108
+Q E + + S++ +A + L++ E L +W+ +
Sbjct: 1198 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTT-----NYQWLC-TRLNGKCK 1251
Query: 1109 ELDDVW----ELQKKFDEFQKDLNTNEPRLR----------DINKVADDLLFEGLL---- 1150
L++VW EL ++ K LN E +L+ +I++V D L E L+
Sbjct: 1252 TLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSL--ENLMRHSE 1309
Query: 1151 -TPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAA 1209
P +I + + G + L +E+ + S H EA ++ +E+ Q+
Sbjct: 1310 DNPNQIRILAQTLTDGGVMDELINEELETFNSRW--RELHEEAVRRQKLLEQSIQSAQET 1367
Query: 1210 DPGSDLFSVQALQRRHEGFERDLVP-LGDKVTI--LGETAERLSE---SHPDATEDLQRQ 1263
+ S+ +Q ++ L + DKV + + A+++ SH + E++++
Sbjct: 1368 EK-----SLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKH 1422
Query: 1264 KMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTG 1323
A L +K+ + + KF LF A Q S + E+ L
Sbjct: 1423 NQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES---KMILDEVKMHLPA 1479
Query: 1324 IEILLERHQEHRADMEAEAPTFQALEDFSAE---LIDSGHHA--------SPEIEKKLQA 1372
+E + ++ + +++L + +E +I +G E+++++ A
Sbjct: 1480 LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTA 1539
Query: 1373 VKLERDDLEKAWEKRKKILDQCLEL-QMFQGNCDQVESWMVARENSL--RSDDKSSLDSL 1429
+KL ++L +RK+ L++CL+L + + + + W+ A + L RS + +L
Sbjct: 1540 LKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNL 1599
Query: 1430 EALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQL 1489
++ + K I Q+ + + E+L + + +L + W A+ ++
Sbjct: 1600 DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 1659
Query: 1490 IDERTKLGDY-ANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKH-----QT 1543
+ L +Y +++ F ++++ + +WI + T DES K + LK
Sbjct: 1660 EEWLNLLLEYQKHMETFDQNVDHITKWIIQ-ADTLLDESEKKKPQQKEDVLKRLKAELND 1718
Query: 1544 FAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKL 1603
+VD +Q ++ + D + ++ Q+ +L + + R GK
Sbjct: 1719 IRPKVDSTRDQAANLM--------ANRGDHCRKLVEPQISELNHRFAAISHRIK-TGKAS 1769
Query: 1604 NEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDAL 1663
++FN+ I+ L EAE + + D N + ++ +E+L R D L
Sbjct: 1770 IPLKELEQFNSDIQKLLEPL-EAEIQQGVNLKEEDFNKDMN--EDNEGTVKELLQRGDNL 1826
Query: 1664 KDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEK-LKEAYALFQFFQDL 1722
+ + ++ Q+++ K N +++L + +K L+ ++ +Q+ +
Sbjct: 1827 Q--QRITDERKREEIKIKQQLLQTKHNA------LKDLRSQRRKKALEISHQWYQYKRQA 1878
Query: 1723 DDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL-KD 1781
DD +++ +++S RD +K K ++ EL + + V AE L +D
Sbjct: 1879 DDLLKCLDDIEKKLASLPEPRD-------ERKIKEIDRELQKKKEELNAVRRQAEGLSED 1931
Query: 1782 KAAVGQEEIQLRLAQFVEHWEKLK-ELAKARGLKLEE----SLEYLQFMQNAEEEEAWIN 1836
AA+ E Q++L+ + W +++ + A+ R L + E + M E
Sbjct: 1932 GAAMAVEPTQIQLS---KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYV 1988
Query: 1837 EKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILN--KVLQEES 1894
L L + LL + DF +++ Q E + N LQ+ S
Sbjct: 1989 PSTYLTEITHVSQALLEVEQLLNAPDLCAKDF-------EDLFKQEESLKNIKDSLQQSS 2041
Query: 1895 QNKEI--SSKIEALNEKTP----SLAKAIAAWKLQLE---------------DDYAFQEF 1933
+I S K AL TP L +A++ Q E ++ F
Sbjct: 2042 GRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRF 2101
Query: 1934 NWKADVVEAWIADKE-----TSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEI 1988
++ + W+ + E T + N A +L L QD + Q++ +
Sbjct: 2102 HYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKEL--QDGIG------QRQTVVRT 2153
Query: 1989 TDLKDKLISAQHNQSKA--IEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFV 2046
+ + I Q +++ A ++E+ +L RW+++ ++L +++ L++ +++
Sbjct: 2154 LNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC-------KQLSDRKKRLEEQKNILS 2206
Query: 2047 EFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELD 2106
EF + W E+ + S P+ ++++ + + + L Q K L E
Sbjct: 2207 EFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETG 2266
Query: 2107 QQIKALGVPSSPYTWLTVE-VLERT---WKHLSDIIEEREQELQKEEARQVKNFEMCQEF 2162
+ + P SP +E L++T W +S + E++ E++ + + + ++
Sbjct: 2267 GPV-LVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDL 2325
Query: 2163 EQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDN 2222
E+ + L W+ R + + G + Q + +QA + + +I+ G +
Sbjct: 2326 EEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ-----ETEIAVQAKQPDVEEILSKGQH 2380
Query: 2223 L--EDALILDIKYSTIGLAQQWDQLYQL 2248
L E +K L+ +W + +L
Sbjct: 2381 LYKEKPATQPVKRKLEDLSSEWKAVNRL 2408
Score = 80.9 bits (198), Expect = 1e-14
Identities = 206/1124 (18%), Positives = 426/1124 (37%), Gaps = 169/1124 (15%)
Query: 1225 HEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKES 1284
H+G +++ LG K+ G+ +E D ++Q Q LN WE L+ + +++ +
Sbjct: 384 HQGRVGNILQLGSKLIGTGKLSE-------DEETEVQEQMNLLNSRWECLRVASMEKQSN 436
Query: 1285 LNEAQKFYLFLSKARDLQNWISSIGGMVSSQE---LAEDLTGIEILLERHQEHRADMEAE 1341
L+ L K ++L +W++ E L DL ++ +++H+ + D+E E
Sbjct: 437 LHRVL-MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQE 495
Query: 1342 APTFQALEDFSAELIDS-GHHASPEIEKKLQAVKLERDDLEKAWEKRKKIL-DQCLELQM 1399
+L + +S G HA+ +E++L+ + ++ + E R +L D L+ Q
Sbjct: 496 QVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQR 555
Query: 1400 FQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAES 1459
+W+ +E+++ +
Sbjct: 556 LTEEQCLFSAWLSEKEDAVNKIHTTGFKD------------------------------- 584
Query: 1460 LIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEM 1519
+ E+ + LQ++ LKA L ++ +G +LKQ +L +
Sbjct: 585 --------QNEMLSSLQKLA----VLKADLEKKKQSMGKLYSLKQ------DLLSTLKNK 626
Query: 1520 LPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQV-HGVINLGNSLIECSACDGNEEAM 1578
T E++ D N R + +++ + Q+ V SL + + +
Sbjct: 627 SVTQKTEAWLD--NFARCW---DNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 681
Query: 1579 KEQLEQLKEHWDHLLERTNDKGKKLNEASR-QQRFNTSIRDFEFWLSEAETLLAMKDQA- 1636
+ +K + L K +++ S ++R + I + W++ +E +L + A
Sbjct: 682 TREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAI 741
Query: 1637 -RDLASAGNLLKKHQLLEREMLAR----EDALKDLNTLAEDLLSSGTFNVDQIVKKKDNV 1691
R + +L +K +ERE + +DA + L E +++ G N D I + + +
Sbjct: 742 FRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV-NADSIKQASEQL 800
Query: 1692 NKRFLNVQELAAAHHEKLKEAYALFQFFQDLDD-------EESWIEEKLIRVSSQDYGRD 1744
N R++ +L + L+ + F+ L E+W++ + S
Sbjct: 801 NSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT---- 856
Query: 1745 LQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKL 1804
+++ LK K L +P I+ + + LK+K G + F H++++
Sbjct: 857 --AIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQ-GPMFLDADFVAFTNHFKQV 913
Query: 1805 KELAKARGLKLE---ESLEYLQFMQNAEEEEAWINEKNA-LAVRGDCGDTLAATQSLLMK 1860
+AR +L+ ++L +++ + W+ + L++ + L +
Sbjct: 914 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 973
Query: 1861 HEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAW 1920
+AL++ ++ + + +++ K E S ++ S+ E + + L+ +
Sbjct: 974 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS--RKYQSEFEEIEGRWKKLSSQLVEH 1031
Query: 1921 KLQLEDDY-AFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQS 1979
+LE+ ++ ++ W+A+ + LK + L KQ L S
Sbjct: 1032 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1091
Query: 1980 FQQERLPEITDLKDKLIS-AQHNQSKAIEERYAALLKRWEQLLEASAVHRQKL---LEKQ 2035
Q L + + K+ + A+ + +E L +W+ + + ++ L LEK
Sbjct: 1092 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1151
Query: 2036 LPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARA 2095
+ LQK DL S ++ W + EE E +LQK E+ + A
Sbjct: 1152 VSLQK--DL--------SEMHEWMTQAEEEYLE--RDFEYKTPDELQKAVEEMKRAKEEA 1199
Query: 2096 Q---ADFKCLLELDQQIKALGVP-------------SSPYTWL---------TVEVLERT 2130
Q A K L E + A P ++ Y WL T+E +
Sbjct: 1200 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1259
Query: 2131 WKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETG 2190
W L +E+ + L + E + +K E + S L
Sbjct: 1260 WHELLSYLEKANKWLNEVEFK-LKTTENIPGGAEEISEVLD------------------- 1299
Query: 2191 TLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGL 2250
+LE+ + ++ +I+ + + LT + D LI + + T +W +L++ +
Sbjct: 1300 SLENLMRHSEDNPNQIRILAQTLTD-----GGVMDELINE-ELETFN--SRWRELHEEAV 1351
Query: 2251 RMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHK 2294
R Q LEQ IQ+ S ++E T D+ L + K
Sbjct: 1352 RRQKLLEQSIQSAQETEKSLHLIQESLTF---IDKQLAAYIADK 1392
Score = 77.8 bits (190), Expect = 1e-13
Identities = 332/1839 (18%), Positives = 699/1839 (38%), Gaps = 277/1839 (15%)
Query: 18 LETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD--LGKWIMEKVNI 75
LET E R Q E+ + Q+ E S HL D L +I +KV+
Sbjct: 1336 LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD- 1394
Query: 76 LTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEE 135
+ + P Q+ Q +++++ + + E++K + G A + + I+
Sbjct: 1395 ----AAQMP-------QEAQKIQSDLTSHEISLEEMKKHNQ-----GKEAAQRVLSQIDV 1438
Query: 136 L-RHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTE 194
+ L D+ ++ L + + F+Q +QE IL+ + + + ++ +++
Sbjct: 1439 AQKKLQDVSMKFRLFQ-----KPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ 1493
Query: 195 V-----LHKKFEDF--QVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWE 247
+ L+K + +VE+V K GR + V + E +E + ++ NE+ A
Sbjct: 1494 LNHCVNLYKSLSEVKSEVEMVIKTGRQI-VQKKQTENPKELDERVTALKLHYNELGAK-- 1550
Query: 248 RLRGLALQRQKALSNAANLQR-FKRDVTEAIQWIKEKEPVLTSEDYGKDLVAS-EGLFHS 305
+R++ L L R ++++ +W+ + LT + + ++ +
Sbjct: 1551 -----VTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAW 1605
Query: 306 HKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEK 365
K ++ + +K + E L +++ L S+W + + A +
Sbjct: 1606 GKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA-EEWLN 1664
Query: 366 LQATYWYHR--FSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYD 423
L Y H F + D ++ W+ + ++ E +VL ++ K E++
Sbjct: 1665 LLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL----KRLKAELNDIR 1720
Query: 424 DRFQSA-DETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFY 482
+ S D+ + N V ++ L++ + A+ HR L
Sbjct: 1721 PKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAI------SHRIKTGKASIPL-- 1772
Query: 483 RDSEQVDSWMSR----------QEAFLENEDLGNSL-----GSAEALLQKHEDFEEAFTA 527
++ EQ +S + + Q L+ ED + G+ + LLQ+ ++ ++ T
Sbjct: 1773 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD 1832
Query: 528 QEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALRE-KAATRRRLLKESLLLQK 586
+ ++ E IK + L + +AL++ ++ R++ L+ S +
Sbjct: 1833 ERKR-------------------EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1873
Query: 587 LYEDSDDLKNWINK-KKKLADDEDYKDIQNLKSRVQKQQVFEKEL--------------- 630
+DDL ++ +KKLA + +D + +K ++ Q ++EL
Sbjct: 1874 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1933
Query: 631 --AVNKTQLENIQKTGQEMIEGGHYASDNV----TTRLSEVASLWEEL-LEATKQKGTQL 683
AV TQ++ ++ + + + N T R + + E++ LE + T L
Sbjct: 1934 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1993
Query: 684 ----HEANQQLQFEN--NAEDL-QRWLEDVEWQVTS-EDYGKGLAEVQNRL-----RKHG 730
H + L+ E NA DL + ED+ Q S ++ L + R+ +K
Sbjct: 1994 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2053
Query: 731 LLESAVAARQDQV-DILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKL 789
L+SA + ++ + L+ L +E++ KD + R + V ++ + + L
Sbjct: 2054 ALQSATPVERVKLQEALSQLDFQWEKVNKM-YKDRQGRFDRSVEKWRRFHYDIKIFNQWL 2112
Query: 790 LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849
+ + R T+ E W E + YL + + + I + +
Sbjct: 2113 TEA---EQFLRKTQIPENW----EHAKYKWYL--------------KELQDGIGQRQTVV 2151
Query: 850 QEITERGNKMVEEGHFA-AEDVASRVKSLNQNMESLRARAARRQNDLEANVQF-QQYLAD 907
+ + G +++++ A + ++ SLN + + + + R+ LE ++ D
Sbjct: 2152 RTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRD 2211
Query: 908 LHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQAN-ACQ 966
L+E W+ E + I E+ L++ + + +L +K L
Sbjct: 2212 LNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV 2271
Query: 967 QQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIV 1026
+P E E ++ + R + K+G++ + + + K+E + Q
Sbjct: 2272 SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ--- 2328
Query: 1027 PAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFL 1086
L H + P R + E N ++ + Q + +A++ + + L
Sbjct: 2329 -------LNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHL 2381
Query: 1087 LAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLF 1146
Y+ + ++ +K E+ E V L ++ Q DL + L+
Sbjct: 2382 --YKEKPATQPVK-RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 2438
Query: 1147 EGLLTPEGAQIRQEL--------------NSRWGSL-------QRLADEQRQLLGSAHAV 1185
+ ++T E A + E+ N W L ++ QR ++G +
Sbjct: 2439 QPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDI 2498
Query: 1186 EVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGET 1245
+ T + +E++ L + + Q L+ + E TI+ +
Sbjct: 2499 NEMIIKQKATMQDLEQRRPQLEEL-----ITAAQNLKNKTSNQEAR--------TIITDR 2545
Query: 1246 AERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKAR-DLQNW 1304
ER+ + E LQ ++ +LNE KD + L ++ L +AR L++W
Sbjct: 2546 IERIQNQWDEVQEHLQNRRQQLNE-------MLKDSTQWLEAKEEAEQVLGQARAKLESW 2598
Query: 1305 ------ISSIGGMVS-SQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELID 1357
+ +I ++ +++LA+DL R + D+ A + L D+SA+
Sbjct: 2599 KEGPYTVDAIQKKITETKQLAKDL--------RQWQTNVDV-ANDLALKLLRDYSADDTR 2649
Query: 1358 SGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQC-LELQMFQGNCDQVESWM----- 1411
H + I +++ + E A E+ ++L Q L+L+ F + E+
Sbjct: 2650 KVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQD 2709
Query: 1412 VARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEI 1471
R+ L D K ++ LMK+ DL I A +L+ ++ ++ + +
Sbjct: 2710 ATRKERLLEDSK----GVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD-- 2763
Query: 1472 ATRLQRVLD----RWKALKAQLIDERTKL-GDYANLKQFYRDLEELEEW-------ISEM 1519
A LQR LD +W L+ + ++ R+ L K+ + L+EL W +S
Sbjct: 2764 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2823
Query: 1520 LPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE--- 1576
P D +Q++ H+ F E+ + + + + +G E+
Sbjct: 2824 APIG-----GDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2878
Query: 1577 ----------------AMKEQLEQLKEHWDHLLERTNDKGKKLNEA-SRQQRFNTSIRDF 1619
+++Q E++ W+ L + D +K++E R Q + +
Sbjct: 2879 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 2938
Query: 1620 EFWLSEAETLLAMKDQARDLA--SAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSG 1677
+ L +AE + DL S + L+K + L E+ ++ + +N LA L + G
Sbjct: 2939 DLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLG 2998
Query: 1678 TFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF 1716
+ +++N R+ +Q +L EA+ F
Sbjct: 2999 IQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDF 3037
>gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]
Length = 3562
Score = 142 bits (359), Expect = 3e-33
Identities = 416/2324 (17%), Positives = 900/2324 (38%), Gaps = 278/2324 (11%)
Query: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDK- 79
A+ I++ +++ +R+ F + ++ER LE ++ F L + N L +
Sbjct: 675 ADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP 734
Query: 80 -SYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTM---GHSAHEETKAHIEE 135
+ +PT I+ + + + EV S L ++E+ + + + G +
Sbjct: 735 TTPSEPTAIKSQLK---ICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAF 791
Query: 136 LRHLWDLLLELTLEKGD--QLLRALKFQQYVQECADILEWIGDKEAIATSVELG-EDWER 192
H + ++ + + + L +Y + + I W+ E + +L D+E
Sbjct: 792 TNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEI 851
Query: 193 TEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPL-IQSKQNEVNAAWERLRG 251
E + + Q L ++ + ++ E +++ ++ QS+ E+ W++L
Sbjct: 852 MEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSS 911
Query: 252 LALQRQKALSNAAN--------LQRFKRDVTEAIQWIKEKEPVL-TSEDYGKDLVASEGL 302
++ + L N +Q K+ + E ++KE+ P L SE K L L
Sbjct: 912 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 971
Query: 303 FHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSR 362
+ ++ +L +++ +++ +AE P A +++ ++L + W+H+ +R
Sbjct: 972 VSDIQTIQPSLNSVNEGGQKIKNEAE------PEFASRLETELKELNTQWDHMCQQVYAR 1025
Query: 363 YEKLQATYWYH-RFSSDFDELSGWMNEKTAAI--------NADELPTDVAGGEVLLDRHQ 413
E L+ D E+ WM + DEL V + + Q
Sbjct: 1026 KEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQ 1085
Query: 414 QHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYE 473
Q + ++ + S + A A + +++++E L N+ L + + + E
Sbjct: 1086 QKEAKVKLLTESVNSV------IAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLE 1139
Query: 474 QCLD-FHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKI 532
+ +H E+ + W++ E L+ + N G AE + + + E E+
Sbjct: 1140 EVWACWHELLSYLEKANKWLNEVEFKLKTTE--NIPGGAEEISEVLDSLENLMRHSEDNP 1197
Query: 533 ITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDS- 591
+ + + + D E I + +R L E+A R++LL++S+ + E S
Sbjct: 1198 NQI-RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1256
Query: 592 ---DDLKNWINKKKK--LADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQE 646
+ +I+K+ +AD D + Q+ Q + +L ++ LE ++K Q
Sbjct: 1257 HLIQESLTFIDKQLAAYIADKVDAAQMP------QEAQKIQSDLTSHEISLEEMKKHNQ- 1309
Query: 647 MIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDV 706
G A+ V LS++ ++L + + + AN FE ++ + L++V
Sbjct: 1310 ----GKEAAQRV---LSQIDVAQKKLQDVSMKFRLFQKPAN----FEQRLQESKMILDEV 1358
Query: 707 EWQVTSEDYGKGLAEV-QNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDS-KDI 764
+ + + + EV Q++L L +++ + +V+++ + ++ K++
Sbjct: 1359 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1418
Query: 765 RARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDE-EAWIQETEPSATS----- 818
R +L + L + RK++L L L R + W+ T+ T
Sbjct: 1419 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1478
Query: 819 ---TYLGKDLI---ASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVAS 872
+ L ++ A++K + + +V L++I ++ + + +VE+
Sbjct: 1479 GMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVED---------- 1528
Query: 873 RVKSLNQNMESLRARAARRQNDL-EANVQFQQYLADLHEAETWIREKEPIVDNTNYGADE 931
++ LN N ++ +RA N L E + + ++ WI + + ++D + +
Sbjct: 1529 KLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQ 1588
Query: 932 EAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQAR 991
+ +LK+ +A +LN + + R+QA + + Q + F A
Sbjct: 1589 QKED-VLKRLKA---ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAI 1644
Query: 992 SPREVTMKKGDVLTLLSSINKDWWKV----EAADHQGI-----------------VPAVY 1030
S R T K L L N D K+ EA QG+
Sbjct: 1645 SHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKEL 1704
Query: 1031 VRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNE-FLLAY 1089
++R + + + +R+REE I +Q+ ++ ++ +L D +RR++ L+ ++ +
Sbjct: 1705 LQRGDNLQQRITDERKREE---IKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKR 1761
Query: 1090 EAGDMLEWIQ--EKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFE 1147
+A D+L+ + EKK + D+ +K E ++L + L + + A+ L +
Sbjct: 1762 QADDLLKCLDDIEKKLASLPEPRDE-----RKIKEIDRELQKKKEELNAVRRQAEGLSED 1816
Query: 1148 GL-LTPEGAQIRQELNSRWGSLQ-RLADEQRQLLGSAHAVE------------------- 1186
G + E QI +L+ RW ++ + A +R H V
Sbjct: 1817 GAAMAVEPTQI--QLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1874
Query: 1187 -VFHREADDTKEQIEKKCQALSAADP-GSDLFSVQALQRRHEGFERDLVPLGDKVTIL-G 1243
+ E + + + Q L+A D D + + + + L ++ I+
Sbjct: 1875 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 1934
Query: 1244 ETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEA-QKFYLFLSKARDLQ 1302
+ L + P LQ +L+ WE + KDR+ + + +K+ F +
Sbjct: 1935 KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 1994
Query: 1303 NWISSIGGMVSSQELAEDLTGIEI--LLERHQEHRADMEAEAPTFQALEDFSAELIDSGH 1360
W++ + ++ E+ + L+ Q+ + T A + E+I
Sbjct: 1995 QWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGE---EIIQQSS 2051
Query: 1361 HASPEI-EKKLQAVKLERDDLEKAWEKRKKILDQCLE-LQMFQGNCDQVESWMVARENSL 1418
I ++KL ++ L ++ K RKK L++ L FQ + ++ W+ +N
Sbjct: 2052 KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIA 2111
Query: 1419 RSD-DKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEE---IATR 1474
+ L+ +++ L + + ++G + L ++ + EE + +
Sbjct: 2112 SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK 2171
Query: 1475 LQRVLDRWKALKAQLIDERTKL-GDYANLKQFYRDLEELEEWISEML----PTACDESYK 1529
L++ +W + L +++ ++ +L Q + LE+LEE ++ +L P
Sbjct: 2172 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY 2231
Query: 1530 DATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHW 1589
+ N + + +T V + V +++ G L + + +K +LE L W
Sbjct: 2232 NQPNQEGPFDVQETEI-AVQAKQPDVEEILSKGQHLYKEKPAT---QPVKRKLEDLSSEW 2287
Query: 1590 ---DHLLERTNDKGKKLN---------------------------------------EAS 1607
+ LL+ K L E
Sbjct: 2288 KAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVP 2347
Query: 1608 RQQRFNTSIRDFEFWLSEAETLL-AMKDQARDLASAGNLLKKHQLLEREMLAREDALKDL 1666
FN + + WLS + ++ + + DL ++ K + +++ R L++L
Sbjct: 2348 ALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEEL 2407
Query: 1667 NTLAEDLLSSGTFNVDQ---IVKKKDNVNKRFLNVQELAAAHHEKLKEAYA-LFQFFQDL 1722
T A++L + T N + I + + + ++ VQE ++L E Q+ +
Sbjct: 2408 ITAAQNLKNK-TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2466
Query: 1723 DDEESWIEEKLIRVSSQDYGR-DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL-K 1780
++ E + + ++ S G + +Q + + K+L +L + + D+A KL +
Sbjct: 2467 EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 2526
Query: 1781 DKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQ-FMQNAEEEEAWINEKN 1839
D +A ++ + W + + R LEE+ LQ F + E+ AW+ E
Sbjct: 2527 DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 2586
Query: 1840 ALA-VRGDCG------DTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQE 1892
A V D + + L+ + + L+ + H N+ + IL L+
Sbjct: 2587 TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS-LEG 2645
Query: 1893 ESQNKEISSKIEALNEKTPSLAKAIAAWKLQLE-DDYAFQEFNWKADVVEAWIADKETSL 1951
+ +++ +N K L K + LE ++ + + W+ K+ L
Sbjct: 2646 SDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2705
Query: 1952 KTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEI-TDLKDKLISAQHNQSKAIEERY 2010
A +G + KQ+ + + + + + P I + L+ I + +E+ Y
Sbjct: 2706 SRQ---APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLY 2762
Query: 2011 ---------------AALLKR--------WEQLLEASAVHRQKL---LEKQLPLQKAED- 2043
LL++ WE+L SA ++K+ LE+ LQ+A D
Sbjct: 2763 QEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDE 2822
Query: 2044 LFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLL 2103
L ++ +W +PV + ++ ++ + + +A + + +
Sbjct: 2823 LDLKLRQAEVIKGSW---------QPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVN 2873
Query: 2104 ELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQK 2147
+L +Q+ LG+ SPY T+E L WK L +E+R ++L +
Sbjct: 2874 DLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHE 2917
Score = 142 bits (357), Expect = 5e-33
Identities = 440/2382 (18%), Positives = 893/2382 (37%), Gaps = 346/2382 (14%)
Query: 68 WIMEK---VNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTM--G 122
W+ EK VN + ++D + QK L+A+++ K + M +L +++ +
Sbjct: 451 WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 510
Query: 123 HSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIAT 182
S ++T+A ++ WD L++ + Q+ +A+ Q ++E + T
Sbjct: 511 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETV-------T 563
Query: 183 SVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEV 242
+V R ++L K A+E P P + +Q V
Sbjct: 564 TVTT-----REQILVKH-------------------------AQEELPPPPPQKKRQITV 593
Query: 243 NAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGL 302
++ + R D+TE WI E VL S ++ + EG
Sbjct: 594 DSEIRK-------------------RLDVDITELHSWITRSEAVLQSPEFA--IFRKEGN 632
Query: 303 FHSHK----GLERNLAVMSDKVKELCAKAEKLT---LSHPSDAPQIQEMKEDLVSSWEHI 355
F K +ER A K+++ A+ L ++ +A I++ E L S W
Sbjct: 633 FSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEF 692
Query: 356 RALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADEL-PTDVAGGEVLLDRHQQ 414
L + R L+ + + + +++L T A N ++ PT + + + +
Sbjct: 693 CQLLSERLNWLE---YQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKI 749
Query: 415 HKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDE------- 467
K E++ S + + + A E + LD ++ A + +
Sbjct: 750 CKDEVNRL-----SGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQA 804
Query: 468 RHRQYEQCLDF--HLFYRDS-EQVDSWMSRQEAFL--------ENEDLGNSLGSAEALLQ 516
R ++ + D + Y+++ + +W+ + E L + E + LG +AL
Sbjct: 805 REKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQS 864
Query: 517 KHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRR 576
++ + + + K A I Y SE + + R L + +
Sbjct: 865 SLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEF-----EEIEGRWKKLSSQLVEHCQ 918
Query: 577 LLKESL-LLQKLYEDSDDLKNWINKKKKLADDE--DYKDIQNLKSRVQKQQVFEKELAVN 633
L+E + L+K+ LK W+ + +E D + LK ++++ ++ ++
Sbjct: 919 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 978
Query: 634 KTQLENIQKTGQEMI-EGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQ-LQ 691
+ L ++ + GQ++ E + + T L E+ + W+ + + + L ++ +
Sbjct: 979 QPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVS 1038
Query: 692 FENNAEDLQRWLEDVEWQVTSEDYG-KGLAEVQNRLRKHGLLESAVAARQDQVDILTDLA 750
+ + ++ W+ E + D+ K E+Q + + + ++ +V +LT+
Sbjct: 1039 LQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESV 1098
Query: 751 AYFEEIGHPDSKD-IRARQESLVCRFEALKEPLATRKKKLLDLLHL-QLICRDTEDEEAW 808
P +++ ++ E+L ++ L L + K L ++ + E W
Sbjct: 1099 NSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKW 1158
Query: 809 IQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAE 868
+ E E +T +++ + ++ LEN+ H + + +G E
Sbjct: 1159 LNEVEFKLKTT---ENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDE 1215
Query: 869 DVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDN--TN 926
+ +++ N L A RRQ LE ++Q Q + ++ I+E +D
Sbjct: 1216 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQ---ETEKSLHLIQESLTFIDKQLAA 1272
Query: 927 YGADEEAAGALLKKHEAFLLDLNSFGDSMKALR--NQANACQQQQAAPVEGVAGEQRVMA 984
Y AD+ A + ++ + DL S S++ ++ NQ Q+ + ++ + + ++
Sbjct: 1273 YIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVS 1332
Query: 985 LYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAH-------- 1036
+ + P + + +L + + A + + + V +L H
Sbjct: 1333 MKFRLFQKPANFEQRLQESKMILDEVKMH---LPALETKSVEQEVVQSQLNHCVNLYKSL 1389
Query: 1037 ----DEFPML--------PQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRL------ 1078
E M+ +++ E P + +R ++ Y L + ER+++L
Sbjct: 1390 SEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKL 1449
Query: 1079 ---LQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLR 1135
+++ L + A +E + E LD K QK++ + L+
Sbjct: 1450 SRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKAT---QKEIEKQKVHLK 1506
Query: 1136 DINKVADDLLFEGLLTPEGAQIRQEL---NSRWGSLQRLADEQRQLLGSAHA-VEVFHRE 1191
I +V + L + +L + + +L NS W ++ A+E LL +E F +
Sbjct: 1507 SITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 1564
Query: 1192 ADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSE 1251
D + I + L ++ L+R + +L + KV + A L
Sbjct: 1565 VDHITKWIIQADTLLDESEKKKPQQKEDVLKR----LKAELNDIRPKVDSTRDQAANLMA 1620
Query: 1252 SHPDATEDL-QRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGG 1310
+ D L + Q ELN + + R K K S+ ++L+ + S I
Sbjct: 1621 NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI-----------PLKELEQFNSDIQK 1669
Query: 1311 MVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEI--EK 1368
++ E AE G+ + + ++ DM + E EL+ G + I E+
Sbjct: 1670 LLEPLE-AEIQQGVNL---KEEDFNKDMNEDN------EGTVKELLQRGDNLQQRITDER 1719
Query: 1369 KLQAVKLERDDLEKAW--------EKRKKILDQCLELQMFQGNCDQVESWMVARENSLRS 1420
K + +K+++ L+ ++RKK L+ + ++ D + + E L S
Sbjct: 1720 KREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLAS 1779
Query: 1421 -----DDKSSLDSLEALMKKRDDLDKAITAQEGKITD----------------------- 1452
D++ + L KK+++L+ EG D
Sbjct: 1780 LPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESK 1839
Query: 1453 LEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEEL 1512
F A H +EE V+ L+ + T L + ++ Q ++E+L
Sbjct: 1840 FAQFRRLNFAQIHTVREET----MMVMTEDMPLEISYVPS-TYLTEITHVSQALLEVEQL 1894
Query: 1513 EEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACD 1572
P C + ++D + + + GR + +H SA
Sbjct: 1895 LN-----APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ----SATP 1945
Query: 1573 GNEEAMKEQLEQLKEHWDHLLERTNDK-GKKLNEASRQQRFNTSIRDFEFWLSEAETLLA 1631
++E L QL W+ + + D+ G+ + +RF+ I+ F WL+EAE L
Sbjct: 1946 VERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLR 2005
Query: 1632 MKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK-DN 1690
K Q + + L+ + R+ ++ LN E+++ + I+++K +
Sbjct: 2006 -KTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2064
Query: 1691 VNKRFLNVQELAAAHHEKLKEAYALFQFFQ-DLDDEESWIEEK-------LIRVSSQDYG 1742
+N R+ V + + ++L+E + FQ DL++ W+EE L Q
Sbjct: 2065 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLK 2124
Query: 1743 RDLQGV----------QNLLKKHKRLEGELVAHEPAIQNVLDMAE-KLKDK--------- 1782
L+ V Q +LK+ G ++ P D E KLK
Sbjct: 2125 EKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSR 2184
Query: 1783 ---AAVGQEEIQLR-LAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEK 1838
G+ E Q++ L Q + E L+E L L L+ +E + ++
Sbjct: 2185 ALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQE 2244
Query: 1839 NALAVRG---DCGDTLA----------ATQSLLMKHEALENDFAVHETRVQNVCAQGEDI 1885
+AV+ D + L+ ATQ + K E L +++ +Q + A+ D+
Sbjct: 2245 TEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDL 2304
Query: 1886 LNKVLQ-EESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWI 1944
+ S + ++ + + K +++K L LE A +FN + W+
Sbjct: 2305 APGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVP-ALADFNRAWTELTDWL 2363
Query: 1945 ADKETSLKTNG-NGADLGDFLTLLAKQDTLDASLQSFQQER--LPEITDLKDKLISAQHN 2001
+ + +K+ DL D ++ KQ A++Q +Q R L E+ L + N
Sbjct: 2364 SLLDQVIKSQRVMVGDLEDINEMIIKQK---ATMQDLEQRRPQLEELITAAQNLKNKTSN 2420
Query: 2002 QSKA--IEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWC 2059
Q I +R + +W+++ E RQ+L E + K ++E +A +
Sbjct: 2421 QEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE----MLKDSTQWLEAKEEAEQVLGQA 2476
Query: 2060 EKMEENLSEPVHCVS-----LNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGV 2114
E+ E + V + E +QL KD + ++ A D +K L
Sbjct: 2477 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAN---------DLALKLLRD 2527
Query: 2115 PSSPYT---WLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQ 2171
S+ T + E + +W+ + + ERE L++ + Q+F + FL
Sbjct: 2528 YSADDTRKVHMITENINASWRSIHKRVSEREAALEETH-------RLLQQFPLDLEKFLA 2580
Query: 2172 WI--LETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL------ 2223
W+ ET A L + KE L + K K+ Q ++ ++ D+ NL
Sbjct: 2581 WLTEAETTANVLQDATRKE--RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQK 2638
Query: 2224 --------EDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLE 2257
+DA++L + + +W +L + L ++ +LE
Sbjct: 2639 ILRSLEGSDDAVLLQRRLDNMNF--KWSELRKKSLNIRSHLE 2678
Score = 131 bits (330), Expect = 7e-30
Identities = 300/1619 (18%), Positives = 628/1619 (38%), Gaps = 149/1619 (9%)
Query: 673 LEATKQK--GTQLHEANQQL-QFENNAEDLQRWLEDVEWQVTSE-DYGKGLAEVQNRLRK 728
LEA + K G+ L E+ L +++ E++ WL E + ++ + + V+++
Sbjct: 199 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT 258
Query: 729 HGLLESAVAARQDQVDILTDLAAYF---EEIGHPDSKDIRARQESLVCRFEALKEPLATR 785
H + A Q +V + L + ++ + +++ + L R+E L+ +
Sbjct: 259 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 318
Query: 786 KKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY---LGKDLIASKKLLNRHRVILENI 842
+ L +L + L + ++ W+ +TE LG DL K+ + +H+V+ E++
Sbjct: 319 QSNLHRVL-MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDL 377
Query: 843 ASHEPRIQEITERGNKMVE-EGHFAAEDVASRVKSLNQNMESLRARAARRQNDL-EANVQ 900
+ R+ +T + E G A + ++K L ++ R L + ++
Sbjct: 378 EQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLK 437
Query: 901 FQQYLADLHEAETWIREKEPIVD--NTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKAL 958
+Q+ + W+ EKE V+ +T D+ + L+K DL SM L
Sbjct: 438 WQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 497
Query: 959 RNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMK-KGDVLTLLSSINKDWWKV 1017
+ +Q + ++ + Q+ A D AR + K + + ++ +
Sbjct: 498 ----YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 553
Query: 1018 EAADHQGIVPAVYVR-----RLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAE 1072
V V R + A +E P P +++ RQ ++++ R LD
Sbjct: 554 TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKK--------RQITVDSEIRKRLD--- 602
Query: 1073 ERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVEL------DDVWELQKKFDEFQKD 1126
+ ++ WI +A E + +L++K + +++
Sbjct: 603 ----------------VDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIERE 646
Query: 1127 LNTNEPRLRDINKVA----DDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSA 1182
+L+D ++ A + ++ EG+ Q ++LNSRW +L E+ L
Sbjct: 647 KAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQ 706
Query: 1183 HAVEVFHREADDTKEQIEK-----KCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGD 1237
+ + F+ + ++ K Q + ++P + + S + + L P +
Sbjct: 707 NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP-TAIKSQLKICKDEVNRLSGLQPQIE 765
Query: 1238 KVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSK 1297
++ I + + D + + D+Q R K+ +++ + +
Sbjct: 766 RLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKE-LQTIFDTLPPMRYQET 824
Query: 1298 ARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELID 1357
++ W+ +S +L+ +T EI+ +R E +A + L S + +
Sbjct: 825 MSAIRTWVQQSETKLSIPQLS--VTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE 882
Query: 1358 SGHHASPEIEKKLQAVKLERDDLEKAWEKR--------KKILDQCLELQMFQGNCDQVES 1409
A EI +K Q+ E +++E W+K +K+ +Q +L+ Q + ++
Sbjct: 883 MSKKAPSEISRKYQS---EFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKK 939
Query: 1410 WMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKE 1469
WM A + ++ +L E L K+ ++ + L E ++ A+
Sbjct: 940 WM-AEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEP 998
Query: 1470 EIATRLQRVL----DRWKALKAQLIDERTKL-GDYANLKQFYRDLEELEEWISEMLPTAC 1524
E A+RL+ L +W + Q+ + L G +DL E+ EW+++
Sbjct: 999 EFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYL 1058
Query: 1525 --DESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQL 1582
D YK +Q+ + + E + +V + NS+I A +EA+K++L
Sbjct: 1059 ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVI-AQAPPVAQEALKKEL 1117
Query: 1583 EQLKEHWDHLLERTNDKGKKLNEA--------SRQQRFNTSIRDFEFWLSEAETLLAMKD 1634
E L ++ L R N K K L E S ++ N + + EF L E + +
Sbjct: 1118 ETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE 1177
Query: 1635 QARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK-DNVNK 1693
+ ++ + LE M ED + LA+ L G +D+++ ++ + N
Sbjct: 1178 EISEVLDS---------LENLMRHSEDNPNQIRILAQTLTDGGV--MDELINEELETFNS 1226
Query: 1694 RFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQ--DYGRDLQGVQNL 1751
R+ + E A + L+++ Q Q+ + I+E L + Q Y D +
Sbjct: 1227 RWRELHEEAVRRQKLLEQS---IQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQM 1283
Query: 1752 LKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKAR 1811
++ ++++ +L +HE +++ + K G+E Q L+Q +KL++++
Sbjct: 1284 PQEAQKIQSDLTSHEISLEEM--------KKHNQGKEAAQRVLSQIDVAQKKLQDVS--- 1332
Query: 1812 GLKLEESLEYLQFMQNAEEEEAWINE-KNALAVRGDCGDTLAATQSLLMKHEALENDFAV 1870
+K + F Q +E + ++E K L QS L L +
Sbjct: 1333 -MKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSE 1391
Query: 1871 HETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAF 1930
++ V+ V G I+ K ++ KE+ ++ AL L + K QLE
Sbjct: 1392 VKSEVEMVIKTGRQIVQK--KQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKL 1449
Query: 1931 -QEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEIT 1989
++ + +V+ W+A + L + L Q+ L IT
Sbjct: 1450 SRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSIT 1509
Query: 1990 DLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE---DLFV 2046
++ + L + + +E++ + L W + + LLE Q ++ + D
Sbjct: 1510 EVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1569
Query: 2047 EFAHKASALNNWCEKMEENLSEPV---HCVSLNEIRQLQKDHEDFLASLARAQADFKCLL 2103
++ +A L + EK + E V LN+IR D A+L + D C
Sbjct: 1570 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGD-HCRK 1628
Query: 2104 ELDQQIKALGVPSSPYTW--------LTVEVLERTWKHLSDIIEEREQELQKEEARQVKN 2155
++ QI L + + + ++ LE+ + ++E E E+Q+ + ++
Sbjct: 1629 LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEED 1688
Query: 2156 F--EMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQ 2212
F +M ++ E LQ + D +E + L+ K++++ +R+
Sbjct: 1689 FNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRK 1747
Score = 130 bits (327), Expect = 2e-29
Identities = 396/2157 (18%), Positives = 827/2157 (38%), Gaps = 335/2157 (15%)
Query: 8 TVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYH-LQVFKRDADDLG 66
TV E S E + + Q +E+ R++ ++ E QKLE+ + L+ + L
Sbjct: 879 TVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLK 938
Query: 67 KWIMEKVNILTDK--SYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHS 124
KW+ E L ++ + D ++ + ++ + L +++QT + L E + +
Sbjct: 939 KWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQT---IQPSLNSVNEGGQKIKNE 995
Query: 125 AHEETKAHIE----ELRHLWDLLLELTLEKGDQLLRALKFQQYVQ-ECADILEWIGDKEA 179
A E + +E EL WD + + + + L L+ +Q + +++ EW+ E
Sbjct: 996 AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE 1055
Query: 180 IATSVELGEDWERTEVLHKKFEDFQ---VELVAKEGRVVEVNQYANECAEENHPDLPLIQ 236
+E +++ + L K E+ + E KE +V + + N + P
Sbjct: 1056 --EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEAL 1113
Query: 237 SKQNEV---NAAW--ERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVL-TSE 290
K+ E N W RL G ++ + L + + +A +W+ E E L T+E
Sbjct: 1114 KKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY---LEKANKWLNEVEFKLKTTE 1170
Query: 291 DYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVS 350
+ +E + LE + D ++ A+ LT D I E E S
Sbjct: 1171 NIPG---GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDE-LINEELETFNS 1226
Query: 351 SWEHIRALATSRY----EKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGE 406
W + A R + +Q+ + E +++++ AA AD++ E
Sbjct: 1227 RWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE 1286
Query: 407 VLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWD 466
+ HEI S +E + N EA+ V ++++ L+
Sbjct: 1287 AQKIQSDLTSHEI--------SLEEMKKH--NQGKEAAQRVLSQIDVAQKK----LQDVS 1332
Query: 467 ERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFT 526
+ R +++ +F ++S+ + + LE + + + ++ L + ++ +
Sbjct: 1333 MKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEV--VQSQLNHCVNLYKSLS 1390
Query: 527 AQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARR---DALREKAATRRRLLKESLL 583
+ ++ V KT +++ +EN K + + + A + + L K R++ L++ L
Sbjct: 1391 EVKSEVEMVIKTGRQIV--QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK 1448
Query: 584 L-QKLYEDSDDLKNWINKKK-KLADDEDYKDI-QNLKSRVQKQQVFEKELAVNKTQLENI 640
L +K+ ++ + L W+ +L + + NL S V + +KE+ K L++I
Sbjct: 1449 LSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI 1508
Query: 641 QKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FENNAEDL 699
+ G+ + V +LS + S W + ++ L E + ++ F+ N + +
Sbjct: 1509 TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHI 1568
Query: 700 QRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAA-YFEEIGH 758
+W+ + + E K + ++ L++ L++ + + +VD D AA G
Sbjct: 1569 TKWIIQAD-TLLDESEKKKPQQKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGD 1624
Query: 759 PDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQET-EPSAT 817
K + + L RF A+ + T K + ++ E + IQ+ EP
Sbjct: 1625 HCRKLVEPQISELNHRFAAISHRIKTGKASIP--------LKELEQFNSDIQKLLEPLEA 1676
Query: 818 STYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEE--GHFAAEDVASRVK 875
G +L ++ N+ + +E ++E+ +RG+ + + E++ + +
Sbjct: 1677 EIQQGVNL--KEEDFNK-----DMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQ 1729
Query: 876 SLNQNMESLR-ARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAA 934
L +L+ R+ RR+ LE + Q+ QY + + + E + + DE
Sbjct: 1730 LLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDE--- 1786
Query: 935 GALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQA------------------------ 970
+K + +L + + A+R QA + A
Sbjct: 1787 ----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQ 1842
Query: 971 ------APVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVE------ 1018
A + V E ++ D P E++ LT ++ +++ +VE
Sbjct: 1843 FRRLNFAQIHTVREETMMVMTEDM----PLEISYVPSTYLTEITHVSQALLEVEQLLNAP 1898
Query: 1019 ---AADHQ--------------------GIVPAVYVRRLA--HDEFPMLPQRRREEPGNI 1053
A D + G + ++ ++ A P+ + +E +
Sbjct: 1899 DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL 1958
Query: 1054 TQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDV 1113
+ E++ Y+ R + R ++++ F Y+ +W+ E + ++ +
Sbjct: 1959 DFQWEKVNKMYKDRQGRFD----RSVEKWRRF--HYDIKIFNQWLTEAEQFLRKTQIPEN 2012
Query: 1114 WELQKK---FDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE----LNSRWG 1166
WE K E Q + + +R +N ++++ + T A I QE LN RW
Sbjct: 2013 WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD--ASILQEKLGSLNLRWQ 2070
Query: 1167 SL-QRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAA-DPGSDLFSVQALQR- 1223
+ ++L+D +++L + + F R+ ++ +E+ S +PG + + L++
Sbjct: 2071 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQV 2130
Query: 1224 --------RHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQ 1275
+G + L G V + + + + + Q ++++ A + Q
Sbjct: 2131 KLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ 2190
Query: 1276 GRTKDRKESLNEAQKFYLFLSKARDLQN-------WISSIGGMVSSQELAEDLTGIEILL 1328
G + + + L + +K K DL+ W+S I +EI
Sbjct: 2191 GEIEAQIKDLGQLEK------KLEDLEEQLNHLLLWLSPIRNQ------------LEIYN 2232
Query: 1329 ERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRK 1388
+ +QE D++ QA + E++ G H E + Q VK + +DL W+
Sbjct: 2233 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE-KPATQPVKRKLEDLSSEWKAVN 2291
Query: 1389 KILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEG 1448
++L + L K+ DL +T
Sbjct: 2292 RLLQE--------------------------------------LRAKQPDLAPGLTTIGA 2313
Query: 1449 KITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRD 1508
T +L+ KE ++L+ + + L+ E L D F R
Sbjct: 2314 SPTQ----TVTLVTQPVVTKETAISKLE--------MPSSLMLEVPALAD------FNRA 2355
Query: 1509 LEELEEWISEMLPTACDESYK--DATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLI 1566
EL +W+S + + D +I +K + +++ R Q+ +I +L
Sbjct: 2356 WTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLK 2415
Query: 1567 ECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEA 1626
++ + +++E+++ WD + E +R+Q+ N ++D WL
Sbjct: 2416 NKTSNQEARTIITDRIERIQNQWDEVQEHLQ---------NRRQQLNEMLKDSTQWLEAK 2466
Query: 1627 ETLLAMKDQARDLASAG-------NLLKKHQLLEREMLARE--------DALKDLN-TLA 1670
E + QAR + + ++K ++ E + LA++ D DL L
Sbjct: 2467 EEAEQVLGQARAKLESWKEGPYTVDAIQK-KITETKQLAKDLRQWQTNVDVANDLALKLL 2525
Query: 1671 EDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQ-DLDDEESWI 1729
D + T V I +N+N + ++ + + L+E + L Q F DL+ +W+
Sbjct: 2526 RDYSADDTRKVHMIT---ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL 2582
Query: 1730 EEKLIRVS-SQDYGR------DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDK 1782
E + QD R D +GV+ L+K+ + L+GE+ AH N+ + ++K+ +
Sbjct: 2583 TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL-R 2641
Query: 1783 AAVGQEE---IQLRLAQFVEHWEKLKELAKARGLKLEESL-EYLQFMQNAEEEEAWINEK 1838
+ G ++ +Q RL W +L++ + LE S ++ + + +E W+ K
Sbjct: 2642 SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 2701
Query: 1839 -NALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQN--------VCAQGEDILNKV 1889
+ L+ + G A Q H A + + E + + + Q + L K+
Sbjct: 2702 DDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKL 2761
Query: 1890 LQE----------ESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDY-AFQEFNWKAD 1938
QE ++ + + + E +N + L A W+ ++++ QE D
Sbjct: 2762 YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 2821
Query: 1939 VVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKL 1995
++ + E G+ +GD L D+L L+ + R EI LK+ +
Sbjct: 2822 ELDLKLRQAEV---IKGSWQPVGDLLI-----DSLQDHLEKVKALR-GEIAPLKENV 2869
Score = 128 bits (321), Expect = 8e-29
Identities = 407/2123 (19%), Positives = 796/2123 (37%), Gaps = 386/2123 (18%)
Query: 5 PKETVVESSGPKVLETAE-----EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQV-F 58
P V G K+ AE ++ +E+ T++ ++V R + L+ V
Sbjct: 980 PSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSL 1039
Query: 59 KRDADDLGKWIM--EKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKS---RLMSE--- 110
++D ++ +W+ E+ + D Y+ P +Q ++ + + E Q K +L++E
Sbjct: 1040 QKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVN 1099
Query: 111 -------------LEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELT--LEKGDQLL 155
L+K E T + L +W EL LEK ++ L
Sbjct: 1100 SVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWL 1159
Query: 156 RALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAK---EG 212
++F+ E G E I+ ++ E+ R H + Q+ ++A+ +G
Sbjct: 1160 NEVEFKLKTTENIP-----GGAEEISEVLDSLENLMR----HSEDNPNQIRILAQTLTDG 1210
Query: 213 RVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRD 272
V++ LI + N+ W L A++RQK L
Sbjct: 1211 GVMD----------------ELINEELETFNSRWRELHEEAVRRQKLLE----------- 1243
Query: 273 VTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKV--KELCAKAEKL 330
++IQ +E E L + E L K L A ++DKV ++ +A+K+
Sbjct: 1244 --QSIQSAQETEKSLH--------LIQESLTFIDKQL---AAYIADKVDAAQMPQEAQKI 1290
Query: 331 TLSHPSDAPQIQEMKEDLVSSWEHIRAL-----ATSRYEKLQATYWYHRFSSDFDE--LS 383
S ++EMK+ R L A + + + + + ++F++
Sbjct: 1291 QSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQE 1350
Query: 384 GWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADE------TGQDLV 437
M ++ L T EV+ Q H ++ Y + E TG+ +V
Sbjct: 1351 SKMILDEVKMHLPALETKSVEQEVV---QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV 1407
Query: 438 NANH-EASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQE 496
E E+ E++ L ++ L ER +Q E+CL S ++ M+
Sbjct: 1408 QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKL------SRKMRKEMNVLT 1461
Query: 497 AFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAI 556
+L D+ + SA + + D E A+ +K I K K I + + +
Sbjct: 1462 EWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK 1521
Query: 557 RDGLLARRDALREK---AATRRR------LLKESLLLQKLYEDSDDLKNWINKKKKLADD 607
++ L+ + +L A T R LL+ ++ ++ D + WI + L D+
Sbjct: 1522 KETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDE 1581
Query: 608 EDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQE----MIEGGHYASDNVTTRLS 663
+ K Q QK+ V ++ A + T + M G + V ++S
Sbjct: 1582 SEKKKPQ------QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQIS 1635
Query: 664 EVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQV------TSEDYGK 717
E+ + + K + + E D+Q+ LE +E ++ ED+ K
Sbjct: 1636 ELNHRFAAISHRIKTGKASI----PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK 1691
Query: 718 GLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEA 777
+ E G ++ + + +TD ++I+ +Q+ L + A
Sbjct: 1692 DMNE-----DNEGTVKELLQRGDNLQQRITD---------ERKREEIKIKQQLLQTKHNA 1737
Query: 778 LKEPLATRKKKLLDLLH-LQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHR 836
LK+ + R+KK L++ H R +D + + E S +D K++
Sbjct: 1738 LKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI----- 1792
Query: 837 VILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE 896
+ +Q+ E N + + +ED A+ +E + + ++R ++E
Sbjct: 1793 ---------DRELQKKKEELNAVRRQAEGLSEDGAAMA------VEPTQIQLSKRWREIE 1837
Query: 897 AN-VQFQQY-LADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDS 954
+ QF++ A +H +RE+ +V E+ + +L ++ +
Sbjct: 1838 SKFAQFRRLNFAQIHT----VREETMMV------MTEDMPLEISYVPSTYLTEITHVSQA 1887
Query: 955 MKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDW 1014
+ + NA + DF+ +E ++K
Sbjct: 1888 LLEVEQLLNAPD----------------LCAKDFEDLFKQEESLKN-------------- 1917
Query: 1015 WKVEAADHQGIVPAVYVRRLA--HDEFPMLPQRRREEPGNITQRQEQIENQYR---SLLD 1069
K G + ++ ++ A P+ + +E + + E++ Y+ D
Sbjct: 1918 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 1977
Query: 1070 RAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQK---KFDEFQKD 1126
R+ E+ RR Y+ +W+ E + ++ + WE K E Q
Sbjct: 1978 RSVEKWRR---------FHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDG 2028
Query: 1127 LNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE----LNSRWGSL-QRLADEQRQLLGS 1181
+ + +R +N ++++ + T A I QE LN RW + ++L+D +++L
Sbjct: 2029 IGQRQTVVRTLNATGEEIIQQSSKT--DASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQ 2086
Query: 1182 AHAVEVFHREADDTKEQIEKKCQALS-AADPGSDLFSVQALQR---------RHEGFERD 1231
+ + F R+ ++ +E+ S +PG + + L++ +G +
Sbjct: 2087 KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQ 2146
Query: 1232 LVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKF 1291
L G V + + + + + Q ++++ A + QG + + + L + +K
Sbjct: 2147 LNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEK- 2205
Query: 1292 YLFLSKARDLQN-------WISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPT 1344
K DL+ W+S I +EI + +QE D++
Sbjct: 2206 -----KLEDLEEQLNHLLLWLSPIRNQ------------LEIYNQPNQEGPFDVQETEIA 2248
Query: 1345 FQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQ--MFQG 1402
QA + E++ G H E + Q VK + +DL W+ ++L + Q + G
Sbjct: 2249 VQAKQPDVEEILSKGQHLYKE-KPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPG 2307
Query: 1403 ----------NCDQVESWMVARENSLRSDDKSS----------------------LDSLE 1430
V +V +E ++ + S L L+
Sbjct: 2308 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD 2367
Query: 1431 ALMKKR-------DDLDKAITAQEGKITDLEH---FAESLI---------ADEHYAKEEI 1471
++K + +D+++ I Q+ + DLE E LI A+ I
Sbjct: 2368 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII 2427
Query: 1472 ATRLQRVLDRWKALKAQLIDERTKLGD-YANLKQFYRDLEELEEWISEMLPTACDESYKD 1530
R++R+ ++W ++ L + R +L + + Q+ EE E+ + + A ES+K+
Sbjct: 2428 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQ--ARAKLESWKE 2485
Query: 1531 ----ATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLK 1586
IQ+K + + A ++ V +L L+ + D + + E +
Sbjct: 2486 GPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRK-VHMITENIN 2544
Query: 1587 EHWDHLLERTNDKGKKLNEASR-QQRFNTSIRDFEFWLSEAETLL-AMKDQAR------D 1638
W + +R +++ L E R Q+F + F WL+EAET ++D R D
Sbjct: 2545 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLED 2604
Query: 1639 LASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSS--GTFNVDQIVKKKDNVN---- 1692
L+K+ Q L+ E+ A D +L+ ++ +L S G+ + + ++ DN+N
Sbjct: 2605 SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWS 2664
Query: 1693 ---KRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQ-DYGRDLQGV 1748
K+ LN++ A ++ K + L + W++ K +S Q G D V
Sbjct: 2665 ELRKKSLNIRSHLEASSDQWKRLHL------SLQELLVWLQLKDDELSRQAPIGGDFPAV 2718
Query: 1749 QNLLKKHKRLEGELVAHEPAIQNVLDMA------------EKL---------KDKAAVGQ 1787
Q H+ + EL EP I + L+ EKL +++A
Sbjct: 2719 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 2778
Query: 1788 EEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGD- 1846
++ + + WEKL + K++E+LE LQ +Q A +E + + A ++G
Sbjct: 2779 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA-TDELDLKLRQAEVIKGSW 2837
Query: 1847 --CGDTLA-ATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKI 1903
GD L + Q L K +AL + A + V +V + +Q N S +
Sbjct: 2838 QPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN---LSTL 2894
Query: 1904 EALNEKTPSLAKAIAAWKLQLED 1926
E LN + L A+ QL +
Sbjct: 2895 EDLNTRWKLLQVAVEDRVRQLHE 2917
Score = 115 bits (287), Expect = 7e-25
Identities = 385/2188 (17%), Positives = 838/2188 (38%), Gaps = 305/2188 (13%)
Query: 260 LSNAANLQRFKRDVTEAIQWIKEKEPVLTSE-DYGKDLVASEGLFHSHKGLERNLAVMSD 318
+ + NL R++ + E + W+ E L ++ + D+ + FH+H+G +L
Sbjct: 212 MESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQG 271
Query: 319 KVKELCAKAEKL----TLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHR 374
+V + KL LS + ++QE L S WE +R + + L HR
Sbjct: 272 RVGNILQLGSKLIGTGKLSEDEET-EVQEQMNLLNSRWECLRVASMEKQSNL------HR 324
Query: 375 FSSDFD-----ELSGW----------MNEKTAAINADELPTDVAGGEVLLDRHQQHKHEI 419
D EL+ W M E+ + ++L V +VL + +Q + +
Sbjct: 325 VLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 384
Query: 420 DSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQ-CLDF 478
+S DE+ D A+ + E++++L + W + ++R + L +
Sbjct: 385 NSLTHMVVVVDESSGD------HATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKW 438
Query: 479 HLFYRDSEQVDSWMSRQE---------AFLENEDLGNSLGSAEALL----QKHEDFEEAF 525
+ +W+S +E F + ++ +SL L +K + + +
Sbjct: 439 QRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLY 498
Query: 526 TAQEEKIITV--------------------DKTATKLIGDDHYDSENIKAIRDGL----- 560
+ +++ + T+ D KL S+ + + L
Sbjct: 499 SLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTV 558
Query: 561 ------LARRDALREKAA----------TRRRLLKESLLLQKLYEDSDDLKNWINKKKKL 604
+ R+ + K A +R++ +S + ++L D +L +WI + + +
Sbjct: 559 METVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAV 618
Query: 605 ADDEDYKDIQ---NLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIE---GGHYASDNV 658
++ + N +K E+E A +L++ ++ Q ++E +D++
Sbjct: 619 LQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSI 678
Query: 659 TTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVE-WQVTSEDYGK 717
++ S W E + ++ L N + F N + L++ E W
Sbjct: 679 KQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 738
Query: 718 GLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEA 777
++++L+ + ++ Q Q++ L + +E G + A + F+
Sbjct: 739 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQ-GPMFLDADFVAFTNHFKQ 797
Query: 778 LKEPLATRKKKLLDLLHLQLICRDTEDEEA---WIQETEPSATSTYLG-KDLIASKKLLN 833
+ + R+K+L + R E A W+Q++E + L D ++ L
Sbjct: 798 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 857
Query: 834 RHRVILENIASHE-------PRIQEITERGNKMVEEGHFAA-EDVASRVKSLNQNMESLR 885
+ + ++ + ++E++++ + + + E++ R K L+ +
Sbjct: 858 ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHC 917
Query: 886 ARAARRQNDLEANVQFQQYLAD-LHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAF 944
+ + N L Q L + E + +++E+ P + D E LK+
Sbjct: 918 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPAL------GDSEILKKQLKQCRLL 971
Query: 945 LLDLNSFGDSMKALRNQA----NACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKK 1000
+ D+ + S+ ++ N + + A+ +E E + Q R+ +K
Sbjct: 972 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1031
Query: 1001 GDVLTLLSSINKDW-----WKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQ 1055
G L S+ KD W +A + Y+ R + P Q+ EE +
Sbjct: 1032 G--LEKTVSLQKDLSEMHEWMTQAEEE-------YLERDFEYKTPDELQKAVEEMKRAKE 1082
Query: 1056 RQEQIENQYR-------SLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGV 1108
+Q E + + S++ +A + L++ E L +W+ +
Sbjct: 1083 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTT-----NYQWLC-TRLNGKCK 1136
Query: 1109 ELDDVW----ELQKKFDEFQKDLNTNEPRLR----------DINKVADDLLFEGLL---- 1150
L++VW EL ++ K LN E +L+ +I++V D L E L+
Sbjct: 1137 TLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSL--ENLMRHSE 1194
Query: 1151 -TPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAA 1209
P +I + + G + L +E+ + S H EA ++ +E+ Q+
Sbjct: 1195 DNPNQIRILAQTLTDGGVMDELINEELETFNSRW--RELHEEAVRRQKLLEQSIQSAQET 1252
Query: 1210 DPGSDLFSVQALQRRHEGFERDLVP-LGDKVTI--LGETAERLSE---SHPDATEDLQRQ 1263
+ S+ +Q ++ L + DKV + + A+++ SH + E++++
Sbjct: 1253 EK-----SLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKH 1307
Query: 1264 KMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTG 1323
A L +K+ + + KF LF A Q S + E+ L
Sbjct: 1308 NQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES---KMILDEVKMHLPA 1364
Query: 1324 IEILLERHQEHRADMEAEAPTFQALEDFSAE---LIDSGHHA--------SPEIEKKLQA 1372
+E + ++ + +++L + +E +I +G E+++++ A
Sbjct: 1365 LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTA 1424
Query: 1373 VKLERDDLEKAWEKRKKILDQCLEL-QMFQGNCDQVESWMVARENSL--RSDDKSSLDSL 1429
+KL ++L +RK+ L++CL+L + + + + W+ A + L RS + +L
Sbjct: 1425 LKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNL 1484
Query: 1430 EALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQL 1489
++ + K I Q+ + + E+L + + +L + W A+ ++
Sbjct: 1485 DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 1544
Query: 1490 IDERTKLGDY-ANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKH-----QT 1543
+ L +Y +++ F ++++ + +WI + T DES K + LK
Sbjct: 1545 EEWLNLLLEYQKHMETFDQNVDHITKWIIQ-ADTLLDESEKKKPQQKEDVLKRLKAELND 1603
Query: 1544 FAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKL 1603
+VD +Q ++ + D + ++ Q+ +L + + R GK
Sbjct: 1604 IRPKVDSTRDQAANLM--------ANRGDHCRKLVEPQISELNHRFAAISHRIK-TGKAS 1654
Query: 1604 NEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDAL 1663
++FN+ I+ L EAE + + D N + ++ +E+L R D L
Sbjct: 1655 IPLKELEQFNSDIQKLLEPL-EAEIQQGVNLKEEDFNKDMN--EDNEGTVKELLQRGDNL 1711
Query: 1664 KDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEK-LKEAYALFQFFQDL 1722
+ + ++ Q+++ K N +++L + +K L+ ++ +Q+ +
Sbjct: 1712 Q--QRITDERKREEIKIKQQLLQTKHNA------LKDLRSQRRKKALEISHQWYQYKRQA 1763
Query: 1723 DDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL-KD 1781
DD +++ +++S RD +K K ++ EL + + V AE L +D
Sbjct: 1764 DDLLKCLDDIEKKLASLPEPRD-------ERKIKEIDRELQKKKEELNAVRRQAEGLSED 1816
Query: 1782 KAAVGQEEIQLRLAQFVEHWEKLK-ELAKARGLKLEE----SLEYLQFMQNAEEEEAWIN 1836
AA+ E Q++L+ + W +++ + A+ R L + E + M E
Sbjct: 1817 GAAMAVEPTQIQLS---KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYV 1873
Query: 1837 EKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILN--KVLQEES 1894
L L + LL + DF +++ Q E + N LQ+ S
Sbjct: 1874 PSTYLTEITHVSQALLEVEQLLNAPDLCAKDF-------EDLFKQEESLKNIKDSLQQSS 1926
Query: 1895 QNKEI--SSKIEALNEKTP----SLAKAIAAWKLQLE---------------DDYAFQEF 1933
+I S K AL TP L +A++ Q E ++ F
Sbjct: 1927 GRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRF 1986
Query: 1934 NWKADVVEAWIADKE-----TSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEI 1988
++ + W+ + E T + N A +L L QD + Q++ +
Sbjct: 1987 HYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKEL--QDGIG------QRQTVVRT 2038
Query: 1989 TDLKDKLISAQHNQSKA--IEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFV 2046
+ + I Q +++ A ++E+ +L RW+++ ++L +++ L++ +++
Sbjct: 2039 LNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC-------KQLSDRKKRLEEQKNILS 2091
Query: 2047 EFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELD 2106
EF + W E+ + S P+ ++++ + + + L Q K L E
Sbjct: 2092 EFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETG 2151
Query: 2107 QQIKALGVPSSPYTWLTVE-VLERT---WKHLSDIIEEREQELQKEEARQVKNFEMCQEF 2162
+ + P SP +E L++T W +S + E++ E++ + + + ++
Sbjct: 2152 GPV-LVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDL 2210
Query: 2163 EQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDN 2222
E+ + L W+ R + + G + Q + +QA + + +I+ G +
Sbjct: 2211 EEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ-----ETEIAVQAKQPDVEEILSKGQH 2265
Query: 2223 L--EDALILDIKYSTIGLAQQWDQLYQL 2248
L E +K L+ +W + +L
Sbjct: 2266 LYKEKPATQPVKRKLEDLSSEWKAVNRL 2293
Score = 80.9 bits (198), Expect = 1e-14
Identities = 206/1124 (18%), Positives = 426/1124 (37%), Gaps = 169/1124 (15%)
Query: 1225 HEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKES 1284
H+G +++ LG K+ G+ +E D ++Q Q LN WE L+ + +++ +
Sbjct: 269 HQGRVGNILQLGSKLIGTGKLSE-------DEETEVQEQMNLLNSRWECLRVASMEKQSN 321
Query: 1285 LNEAQKFYLFLSKARDLQNWISSIGGMVSSQE---LAEDLTGIEILLERHQEHRADMEAE 1341
L+ L K ++L +W++ E L DL ++ +++H+ + D+E E
Sbjct: 322 LHRVL-MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQE 380
Query: 1342 APTFQALEDFSAELIDS-GHHASPEIEKKLQAVKLERDDLEKAWEKRKKIL-DQCLELQM 1399
+L + +S G HA+ +E++L+ + ++ + E R +L D L+ Q
Sbjct: 381 QVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQR 440
Query: 1400 FQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAES 1459
+W+ +E+++ +
Sbjct: 441 LTEEQCLFSAWLSEKEDAVNKIHTTGFKD------------------------------- 469
Query: 1460 LIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEM 1519
+ E+ + LQ++ LKA L ++ +G +LKQ +L +
Sbjct: 470 --------QNEMLSSLQKLA----VLKADLEKKKQSMGKLYSLKQ------DLLSTLKNK 511
Query: 1520 LPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQV-HGVINLGNSLIECSACDGNEEAM 1578
T E++ D N R + +++ + Q+ V SL + + +
Sbjct: 512 SVTQKTEAWLD--NFARCW---DNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 566
Query: 1579 KEQLEQLKEHWDHLLERTNDKGKKLNEASR-QQRFNTSIRDFEFWLSEAETLLAMKDQA- 1636
+ +K + L K +++ S ++R + I + W++ +E +L + A
Sbjct: 567 TREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAI 626
Query: 1637 -RDLASAGNLLKKHQLLEREMLAR----EDALKDLNTLAEDLLSSGTFNVDQIVKKKDNV 1691
R + +L +K +ERE + +DA + L E +++ G N D I + + +
Sbjct: 627 FRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV-NADSIKQASEQL 685
Query: 1692 NKRFLNVQELAAAHHEKLKEAYALFQFFQDLDD-------EESWIEEKLIRVSSQDYGRD 1744
N R++ +L + L+ + F+ L E+W++ + S
Sbjct: 686 NSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT---- 741
Query: 1745 LQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKL 1804
+++ LK K L +P I+ + + LK+K G + F H++++
Sbjct: 742 --AIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQ-GPMFLDADFVAFTNHFKQV 798
Query: 1805 KELAKARGLKLE---ESLEYLQFMQNAEEEEAWINEKNA-LAVRGDCGDTLAATQSLLMK 1860
+AR +L+ ++L +++ + W+ + L++ + L +
Sbjct: 799 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 858
Query: 1861 HEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAW 1920
+AL++ ++ + + +++ K E S ++ S+ E + + L+ +
Sbjct: 859 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS--RKYQSEFEEIEGRWKKLSSQLVEH 916
Query: 1921 KLQLEDDY-AFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQS 1979
+LE+ ++ ++ W+A+ + LK + L KQ L S
Sbjct: 917 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 976
Query: 1980 FQQERLPEITDLKDKLIS-AQHNQSKAIEERYAALLKRWEQLLEASAVHRQKL---LEKQ 2035
Q L + + K+ + A+ + +E L +W+ + + ++ L LEK
Sbjct: 977 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1036
Query: 2036 LPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARA 2095
+ LQK DL S ++ W + EE E +LQK E+ + A
Sbjct: 1037 VSLQK--DL--------SEMHEWMTQAEEEYLE--RDFEYKTPDELQKAVEEMKRAKEEA 1084
Query: 2096 Q---ADFKCLLELDQQIKALGVP-------------SSPYTWL---------TVEVLERT 2130
Q A K L E + A P ++ Y WL T+E +
Sbjct: 1085 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1144
Query: 2131 WKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETG 2190
W L +E+ + L + E + +K E + S L
Sbjct: 1145 WHELLSYLEKANKWLNEVEFK-LKTTENIPGGAEEISEVLD------------------- 1184
Query: 2191 TLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGL 2250
+LE+ + ++ +I+ + + LT + D LI + + T +W +L++ +
Sbjct: 1185 SLENLMRHSEDNPNQIRILAQTLTD-----GGVMDELINE-ELETFN--SRWRELHEEAV 1236
Query: 2251 RMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHK 2294
R Q LEQ IQ+ S ++E T D+ L + K
Sbjct: 1237 RRQKLLEQSIQSAQETEKSLHLIQESLTF---IDKQLAAYIADK 1277
Score = 77.8 bits (190), Expect = 1e-13
Identities = 332/1839 (18%), Positives = 699/1839 (38%), Gaps = 277/1839 (15%)
Query: 18 LETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD--LGKWIMEKVNI 75
LET E R Q E+ + Q+ E S HL D L +I +KV+
Sbjct: 1221 LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD- 1279
Query: 76 LTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEE 135
+ + P Q+ Q +++++ + + E++K + G A + + I+
Sbjct: 1280 ----AAQMP-------QEAQKIQSDLTSHEISLEEMKKHNQ-----GKEAAQRVLSQIDV 1323
Query: 136 L-RHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTE 194
+ L D+ ++ L + + F+Q +QE IL+ + + + ++ +++
Sbjct: 1324 AQKKLQDVSMKFRLFQ-----KPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ 1378
Query: 195 V-----LHKKFEDF--QVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWE 247
+ L+K + +VE+V K GR + V + E +E + ++ NE+ A
Sbjct: 1379 LNHCVNLYKSLSEVKSEVEMVIKTGRQI-VQKKQTENPKELDERVTALKLHYNELGAK-- 1435
Query: 248 RLRGLALQRQKALSNAANLQR-FKRDVTEAIQWIKEKEPVLTSEDYGKDLVAS-EGLFHS 305
+R++ L L R ++++ +W+ + LT + + ++ +
Sbjct: 1436 -----VTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAW 1490
Query: 306 HKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEK 365
K ++ + +K + E L +++ L S+W + + A +
Sbjct: 1491 GKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA-EEWLN 1549
Query: 366 LQATYWYHR--FSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYD 423
L Y H F + D ++ W+ + ++ E +VL ++ K E++
Sbjct: 1550 LLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL----KRLKAELNDIR 1605
Query: 424 DRFQSA-DETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFY 482
+ S D+ + N V ++ L++ + A+ HR L
Sbjct: 1606 PKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAI------SHRIKTGKASIPL-- 1657
Query: 483 RDSEQVDSWMSR----------QEAFLENEDLGNSL-----GSAEALLQKHEDFEEAFTA 527
++ EQ +S + + Q L+ ED + G+ + LLQ+ ++ ++ T
Sbjct: 1658 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD 1717
Query: 528 QEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALRE-KAATRRRLLKESLLLQK 586
+ ++ E IK + L + +AL++ ++ R++ L+ S +
Sbjct: 1718 ERKR-------------------EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1758
Query: 587 LYEDSDDLKNWINK-KKKLADDEDYKDIQNLKSRVQKQQVFEKEL--------------- 630
+DDL ++ +KKLA + +D + +K ++ Q ++EL
Sbjct: 1759 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1818
Query: 631 --AVNKTQLENIQKTGQEMIEGGHYASDNV----TTRLSEVASLWEEL-LEATKQKGTQL 683
AV TQ++ ++ + + + N T R + + E++ LE + T L
Sbjct: 1819 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1878
Query: 684 ----HEANQQLQFEN--NAEDL-QRWLEDVEWQVTS-EDYGKGLAEVQNRL-----RKHG 730
H + L+ E NA DL + ED+ Q S ++ L + R+ +K
Sbjct: 1879 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 1938
Query: 731 LLESAVAARQDQV-DILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKL 789
L+SA + ++ + L+ L +E++ KD + R + V ++ + + L
Sbjct: 1939 ALQSATPVERVKLQEALSQLDFQWEKVNKM-YKDRQGRFDRSVEKWRRFHYDIKIFNQWL 1997
Query: 790 LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849
+ + R T+ E W E + YL + + + I + +
Sbjct: 1998 TEA---EQFLRKTQIPENW----EHAKYKWYL--------------KELQDGIGQRQTVV 2036
Query: 850 QEITERGNKMVEEGHFA-AEDVASRVKSLNQNMESLRARAARRQNDLEANVQF-QQYLAD 907
+ + G +++++ A + ++ SLN + + + + R+ LE ++ D
Sbjct: 2037 RTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRD 2096
Query: 908 LHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQAN-ACQ 966
L+E W+ E + I E+ L++ + + +L +K L
Sbjct: 2097 LNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV 2156
Query: 967 QQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIV 1026
+P E E ++ + R + K+G++ + + + K+E + Q
Sbjct: 2157 SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ--- 2213
Query: 1027 PAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFL 1086
L H + P R + E N ++ + Q + +A++ + + L
Sbjct: 2214 -------LNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHL 2266
Query: 1087 LAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLF 1146
Y+ + ++ +K E+ E V L ++ Q DL + L+
Sbjct: 2267 --YKEKPATQPVK-RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 2323
Query: 1147 EGLLTPEGAQIRQEL--------------NSRWGSL-------QRLADEQRQLLGSAHAV 1185
+ ++T E A + E+ N W L ++ QR ++G +
Sbjct: 2324 QPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDI 2383
Query: 1186 EVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGET 1245
+ T + +E++ L + + Q L+ + E TI+ +
Sbjct: 2384 NEMIIKQKATMQDLEQRRPQLEEL-----ITAAQNLKNKTSNQEAR--------TIITDR 2430
Query: 1246 AERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKAR-DLQNW 1304
ER+ + E LQ ++ +LNE KD + L ++ L +AR L++W
Sbjct: 2431 IERIQNQWDEVQEHLQNRRQQLNE-------MLKDSTQWLEAKEEAEQVLGQARAKLESW 2483
Query: 1305 ------ISSIGGMVS-SQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELID 1357
+ +I ++ +++LA+DL R + D+ A + L D+SA+
Sbjct: 2484 KEGPYTVDAIQKKITETKQLAKDL--------RQWQTNVDV-ANDLALKLLRDYSADDTR 2534
Query: 1358 SGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQC-LELQMFQGNCDQVESWM----- 1411
H + I +++ + E A E+ ++L Q L+L+ F + E+
Sbjct: 2535 KVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQD 2594
Query: 1412 VARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEI 1471
R+ L D K ++ LMK+ DL I A +L+ ++ ++ + +
Sbjct: 2595 ATRKERLLEDSK----GVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD-- 2648
Query: 1472 ATRLQRVLD----RWKALKAQLIDERTKL-GDYANLKQFYRDLEELEEW-------ISEM 1519
A LQR LD +W L+ + ++ R+ L K+ + L+EL W +S
Sbjct: 2649 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2708
Query: 1520 LPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE--- 1576
P D +Q++ H+ F E+ + + + + +G E+
Sbjct: 2709 APIG-----GDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2763
Query: 1577 ----------------AMKEQLEQLKEHWDHLLERTNDKGKKLNEA-SRQQRFNTSIRDF 1619
+++Q E++ W+ L + D +K++E R Q + +
Sbjct: 2764 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 2823
Query: 1620 EFWLSEAETLLAMKDQARDLA--SAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSG 1677
+ L +AE + DL S + L+K + L E+ ++ + +N LA L + G
Sbjct: 2824 DLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLG 2883
Query: 1678 TFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF 1716
+ +++N R+ +Q +L EA+ F
Sbjct: 2884 IQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDF 2922
>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
Length = 3681
Score = 142 bits (359), Expect = 3e-33
Identities = 416/2324 (17%), Positives = 900/2324 (38%), Gaps = 278/2324 (11%)
Query: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDK- 79
A+ I++ +++ +R+ F + ++ER LE ++ F L + N L +
Sbjct: 794 ADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP 853
Query: 80 -SYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTM---GHSAHEETKAHIEE 135
+ +PT I+ + + + EV S L ++E+ + + + G +
Sbjct: 854 TTPSEPTAIKSQLK---ICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAF 910
Query: 136 LRHLWDLLLELTLEKGD--QLLRALKFQQYVQECADILEWIGDKEAIATSVELG-EDWER 192
H + ++ + + + L +Y + + I W+ E + +L D+E
Sbjct: 911 TNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEI 970
Query: 193 TEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPL-IQSKQNEVNAAWERLRG 251
E + + Q L ++ + ++ E +++ ++ QS+ E+ W++L
Sbjct: 971 MEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSS 1030
Query: 252 LALQRQKALSNAAN--------LQRFKRDVTEAIQWIKEKEPVL-TSEDYGKDLVASEGL 302
++ + L N +Q K+ + E ++KE+ P L SE K L L
Sbjct: 1031 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1090
Query: 303 FHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSR 362
+ ++ +L +++ +++ +AE P A +++ ++L + W+H+ +R
Sbjct: 1091 VSDIQTIQPSLNSVNEGGQKIKNEAE------PEFASRLETELKELNTQWDHMCQQVYAR 1144
Query: 363 YEKLQATYWYH-RFSSDFDELSGWMNEKTAAI--------NADELPTDVAGGEVLLDRHQ 413
E L+ D E+ WM + DEL V + + Q
Sbjct: 1145 KEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQ 1204
Query: 414 QHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYE 473
Q + ++ + S + A A + +++++E L N+ L + + + E
Sbjct: 1205 QKEAKVKLLTESVNSV------IAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLE 1258
Query: 474 QCLD-FHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKI 532
+ +H E+ + W++ E L+ + N G AE + + + E E+
Sbjct: 1259 EVWACWHELLSYLEKANKWLNEVEFKLKTTE--NIPGGAEEISEVLDSLENLMRHSEDNP 1316
Query: 533 ITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDS- 591
+ + + + D E I + +R L E+A R++LL++S+ + E S
Sbjct: 1317 NQI-RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1375
Query: 592 ---DDLKNWINKKKK--LADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQE 646
+ +I+K+ +AD D + Q+ Q + +L ++ LE ++K Q
Sbjct: 1376 HLIQESLTFIDKQLAAYIADKVDAAQMP------QEAQKIQSDLTSHEISLEEMKKHNQ- 1428
Query: 647 MIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDV 706
G A+ V LS++ ++L + + + AN FE ++ + L++V
Sbjct: 1429 ----GKEAAQRV---LSQIDVAQKKLQDVSMKFRLFQKPAN----FEQRLQESKMILDEV 1477
Query: 707 EWQVTSEDYGKGLAEV-QNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDS-KDI 764
+ + + + EV Q++L L +++ + +V+++ + ++ K++
Sbjct: 1478 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1537
Query: 765 RARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDE-EAWIQETEPSATS----- 818
R +L + L + RK++L L L R + W+ T+ T
Sbjct: 1538 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1597
Query: 819 ---TYLGKDLI---ASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVAS 872
+ L ++ A++K + + +V L++I ++ + + +VE+
Sbjct: 1598 GMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVED---------- 1647
Query: 873 RVKSLNQNMESLRARAARRQNDL-EANVQFQQYLADLHEAETWIREKEPIVDNTNYGADE 931
++ LN N ++ +RA N L E + + ++ WI + + ++D + +
Sbjct: 1648 KLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQ 1707
Query: 932 EAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQAR 991
+ +LK+ +A +LN + + R+QA + + Q + F A
Sbjct: 1708 QKED-VLKRLKA---ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAI 1763
Query: 992 SPREVTMKKGDVLTLLSSINKDWWKV----EAADHQGI-----------------VPAVY 1030
S R T K L L N D K+ EA QG+
Sbjct: 1764 SHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKEL 1823
Query: 1031 VRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNE-FLLAY 1089
++R + + + +R+REE I +Q+ ++ ++ +L D +RR++ L+ ++ +
Sbjct: 1824 LQRGDNLQQRITDERKREE---IKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKR 1880
Query: 1090 EAGDMLEWIQ--EKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFE 1147
+A D+L+ + EKK + D+ +K E ++L + L + + A+ L +
Sbjct: 1881 QADDLLKCLDDIEKKLASLPEPRDE-----RKIKEIDRELQKKKEELNAVRRQAEGLSED 1935
Query: 1148 GL-LTPEGAQIRQELNSRWGSLQ-RLADEQRQLLGSAHAVE------------------- 1186
G + E QI +L+ RW ++ + A +R H V
Sbjct: 1936 GAAMAVEPTQI--QLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1993
Query: 1187 -VFHREADDTKEQIEKKCQALSAADP-GSDLFSVQALQRRHEGFERDLVPLGDKVTIL-G 1243
+ E + + + Q L+A D D + + + + L ++ I+
Sbjct: 1994 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2053
Query: 1244 ETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEA-QKFYLFLSKARDLQ 1302
+ L + P LQ +L+ WE + KDR+ + + +K+ F +
Sbjct: 2054 KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 2113
Query: 1303 NWISSIGGMVSSQELAEDLTGIEI--LLERHQEHRADMEAEAPTFQALEDFSAELIDSGH 1360
W++ + ++ E+ + L+ Q+ + T A + E+I
Sbjct: 2114 QWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGE---EIIQQSS 2170
Query: 1361 HASPEI-EKKLQAVKLERDDLEKAWEKRKKILDQCLE-LQMFQGNCDQVESWMVARENSL 1418
I ++KL ++ L ++ K RKK L++ L FQ + ++ W+ +N
Sbjct: 2171 KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIA 2230
Query: 1419 RSD-DKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEE---IATR 1474
+ L+ +++ L + + ++G + L ++ + EE + +
Sbjct: 2231 SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK 2290
Query: 1475 LQRVLDRWKALKAQLIDERTKL-GDYANLKQFYRDLEELEEWISEML----PTACDESYK 1529
L++ +W + L +++ ++ +L Q + LE+LEE ++ +L P
Sbjct: 2291 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY 2350
Query: 1530 DATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHW 1589
+ N + + +T V + V +++ G L + + +K +LE L W
Sbjct: 2351 NQPNQEGPFDVQETEI-AVQAKQPDVEEILSKGQHLYKEKPAT---QPVKRKLEDLSSEW 2406
Query: 1590 ---DHLLERTNDKGKKLN---------------------------------------EAS 1607
+ LL+ K L E
Sbjct: 2407 KAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVP 2466
Query: 1608 RQQRFNTSIRDFEFWLSEAETLL-AMKDQARDLASAGNLLKKHQLLEREMLAREDALKDL 1666
FN + + WLS + ++ + + DL ++ K + +++ R L++L
Sbjct: 2467 ALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEEL 2526
Query: 1667 NTLAEDLLSSGTFNVDQ---IVKKKDNVNKRFLNVQELAAAHHEKLKEAYA-LFQFFQDL 1722
T A++L + T N + I + + + ++ VQE ++L E Q+ +
Sbjct: 2527 ITAAQNLKNK-TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2585
Query: 1723 DDEESWIEEKLIRVSSQDYGR-DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL-K 1780
++ E + + ++ S G + +Q + + K+L +L + + D+A KL +
Sbjct: 2586 EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 2645
Query: 1781 DKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQ-FMQNAEEEEAWINEKN 1839
D +A ++ + W + + R LEE+ LQ F + E+ AW+ E
Sbjct: 2646 DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 2705
Query: 1840 ALA-VRGDCG------DTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQE 1892
A V D + + L+ + + L+ + H N+ + IL L+
Sbjct: 2706 TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS-LEG 2764
Query: 1893 ESQNKEISSKIEALNEKTPSLAKAIAAWKLQLE-DDYAFQEFNWKADVVEAWIADKETSL 1951
+ +++ +N K L K + LE ++ + + W+ K+ L
Sbjct: 2765 SDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2824
Query: 1952 KTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEI-TDLKDKLISAQHNQSKAIEERY 2010
A +G + KQ+ + + + + + P I + L+ I + +E+ Y
Sbjct: 2825 SRQ---APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLY 2881
Query: 2011 ---------------AALLKR--------WEQLLEASAVHRQKL---LEKQLPLQKAED- 2043
LL++ WE+L SA ++K+ LE+ LQ+A D
Sbjct: 2882 QEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDE 2941
Query: 2044 LFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLL 2103
L ++ +W +PV + ++ ++ + + +A + + +
Sbjct: 2942 LDLKLRQAEVIKGSW---------QPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVN 2992
Query: 2104 ELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQK 2147
+L +Q+ LG+ SPY T+E L WK L +E+R ++L +
Sbjct: 2993 DLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHE 3036
Score = 142 bits (357), Expect = 5e-33
Identities = 440/2382 (18%), Positives = 893/2382 (37%), Gaps = 346/2382 (14%)
Query: 68 WIMEK---VNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTM--G 122
W+ EK VN + ++D + QK L+A+++ K + M +L +++ +
Sbjct: 570 WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 629
Query: 123 HSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIAT 182
S ++T+A ++ WD L++ + Q+ +A+ Q ++E + T
Sbjct: 630 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETV-------T 682
Query: 183 SVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEV 242
+V R ++L K A+E P P + +Q V
Sbjct: 683 TVTT-----REQILVKH-------------------------AQEELPPPPPQKKRQITV 712
Query: 243 NAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGL 302
++ + R D+TE WI E VL S ++ + EG
Sbjct: 713 DSEIRK-------------------RLDVDITELHSWITRSEAVLQSPEFA--IFRKEGN 751
Query: 303 FHSHK----GLERNLAVMSDKVKELCAKAEKLT---LSHPSDAPQIQEMKEDLVSSWEHI 355
F K +ER A K+++ A+ L ++ +A I++ E L S W
Sbjct: 752 FSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEF 811
Query: 356 RALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADEL-PTDVAGGEVLLDRHQQ 414
L + R L+ + + + +++L T A N ++ PT + + + +
Sbjct: 812 CQLLSERLNWLE---YQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKI 868
Query: 415 HKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDE------- 467
K E++ S + + + A E + LD ++ A + +
Sbjct: 869 CKDEVNRL-----SGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQA 923
Query: 468 RHRQYEQCLDF--HLFYRDS-EQVDSWMSRQEAFL--------ENEDLGNSLGSAEALLQ 516
R ++ + D + Y+++ + +W+ + E L + E + LG +AL
Sbjct: 924 REKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQS 983
Query: 517 KHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRR 576
++ + + + K A I Y SE + + R L + +
Sbjct: 984 SLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEF-----EEIEGRWKKLSSQLVEHCQ 1037
Query: 577 LLKESL-LLQKLYEDSDDLKNWINKKKKLADDE--DYKDIQNLKSRVQKQQVFEKELAVN 633
L+E + L+K+ LK W+ + +E D + LK ++++ ++ ++
Sbjct: 1038 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1097
Query: 634 KTQLENIQKTGQEMI-EGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQ-LQ 691
+ L ++ + GQ++ E + + T L E+ + W+ + + + L ++ +
Sbjct: 1098 QPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVS 1157
Query: 692 FENNAEDLQRWLEDVEWQVTSEDYG-KGLAEVQNRLRKHGLLESAVAARQDQVDILTDLA 750
+ + ++ W+ E + D+ K E+Q + + + ++ +V +LT+
Sbjct: 1158 LQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESV 1217
Query: 751 AYFEEIGHPDSKD-IRARQESLVCRFEALKEPLATRKKKLLDLLHL-QLICRDTEDEEAW 808
P +++ ++ E+L ++ L L + K L ++ + E W
Sbjct: 1218 NSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKW 1277
Query: 809 IQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAE 868
+ E E +T +++ + ++ LEN+ H + + +G E
Sbjct: 1278 LNEVEFKLKTT---ENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDE 1334
Query: 869 DVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDN--TN 926
+ +++ N L A RRQ LE ++Q Q + ++ I+E +D
Sbjct: 1335 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQ---ETEKSLHLIQESLTFIDKQLAA 1391
Query: 927 YGADEEAAGALLKKHEAFLLDLNSFGDSMKALR--NQANACQQQQAAPVEGVAGEQRVMA 984
Y AD+ A + ++ + DL S S++ ++ NQ Q+ + ++ + + ++
Sbjct: 1392 YIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVS 1451
Query: 985 LYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAH-------- 1036
+ + P + + +L + + A + + + V +L H
Sbjct: 1452 MKFRLFQKPANFEQRLQESKMILDEVKMH---LPALETKSVEQEVVQSQLNHCVNLYKSL 1508
Query: 1037 ----DEFPML--------PQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRL------ 1078
E M+ +++ E P + +R ++ Y L + ER+++L
Sbjct: 1509 SEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKL 1568
Query: 1079 ---LQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLR 1135
+++ L + A +E + E LD K QK++ + L+
Sbjct: 1569 SRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKAT---QKEIEKQKVHLK 1625
Query: 1136 DINKVADDLLFEGLLTPEGAQIRQEL---NSRWGSLQRLADEQRQLLGSAHA-VEVFHRE 1191
I +V + L + +L + + +L NS W ++ A+E LL +E F +
Sbjct: 1626 SITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 1683
Query: 1192 ADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSE 1251
D + I + L ++ L+R + +L + KV + A L
Sbjct: 1684 VDHITKWIIQADTLLDESEKKKPQQKEDVLKR----LKAELNDIRPKVDSTRDQAANLMA 1739
Query: 1252 SHPDATEDL-QRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGG 1310
+ D L + Q ELN + + R K K S+ ++L+ + S I
Sbjct: 1740 NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI-----------PLKELEQFNSDIQK 1788
Query: 1311 MVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEI--EK 1368
++ E AE G+ + + ++ DM + E EL+ G + I E+
Sbjct: 1789 LLEPLE-AEIQQGVNL---KEEDFNKDMNEDN------EGTVKELLQRGDNLQQRITDER 1838
Query: 1369 KLQAVKLERDDLEKAW--------EKRKKILDQCLELQMFQGNCDQVESWMVARENSLRS 1420
K + +K+++ L+ ++RKK L+ + ++ D + + E L S
Sbjct: 1839 KREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLAS 1898
Query: 1421 -----DDKSSLDSLEALMKKRDDLDKAITAQEGKITD----------------------- 1452
D++ + L KK+++L+ EG D
Sbjct: 1899 LPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESK 1958
Query: 1453 LEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEEL 1512
F A H +EE V+ L+ + T L + ++ Q ++E+L
Sbjct: 1959 FAQFRRLNFAQIHTVREET----MMVMTEDMPLEISYVPS-TYLTEITHVSQALLEVEQL 2013
Query: 1513 EEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACD 1572
P C + ++D + + + GR + +H SA
Sbjct: 2014 LN-----APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ----SATP 2064
Query: 1573 GNEEAMKEQLEQLKEHWDHLLERTNDK-GKKLNEASRQQRFNTSIRDFEFWLSEAETLLA 1631
++E L QL W+ + + D+ G+ + +RF+ I+ F WL+EAE L
Sbjct: 2065 VERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLR 2124
Query: 1632 MKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK-DN 1690
K Q + + L+ + R+ ++ LN E+++ + I+++K +
Sbjct: 2125 -KTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2183
Query: 1691 VNKRFLNVQELAAAHHEKLKEAYALFQFFQ-DLDDEESWIEEK-------LIRVSSQDYG 1742
+N R+ V + + ++L+E + FQ DL++ W+EE L Q
Sbjct: 2184 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLK 2243
Query: 1743 RDLQGV----------QNLLKKHKRLEGELVAHEPAIQNVLDMAE-KLKDK--------- 1782
L+ V Q +LK+ G ++ P D E KLK
Sbjct: 2244 EKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSR 2303
Query: 1783 ---AAVGQEEIQLR-LAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEK 1838
G+ E Q++ L Q + E L+E L L L+ +E + ++
Sbjct: 2304 ALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQE 2363
Query: 1839 NALAVRG---DCGDTLA----------ATQSLLMKHEALENDFAVHETRVQNVCAQGEDI 1885
+AV+ D + L+ ATQ + K E L +++ +Q + A+ D+
Sbjct: 2364 TEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDL 2423
Query: 1886 LNKVLQ-EESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWI 1944
+ S + ++ + + K +++K L LE A +FN + W+
Sbjct: 2424 APGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVP-ALADFNRAWTELTDWL 2482
Query: 1945 ADKETSLKTNG-NGADLGDFLTLLAKQDTLDASLQSFQQER--LPEITDLKDKLISAQHN 2001
+ + +K+ DL D ++ KQ A++Q +Q R L E+ L + N
Sbjct: 2483 SLLDQVIKSQRVMVGDLEDINEMIIKQK---ATMQDLEQRRPQLEELITAAQNLKNKTSN 2539
Query: 2002 QSKA--IEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWC 2059
Q I +R + +W+++ E RQ+L E + K ++E +A +
Sbjct: 2540 QEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE----MLKDSTQWLEAKEEAEQVLGQA 2595
Query: 2060 EKMEENLSEPVHCVS-----LNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGV 2114
E+ E + V + E +QL KD + ++ A D +K L
Sbjct: 2596 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAN---------DLALKLLRD 2646
Query: 2115 PSSPYT---WLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQ 2171
S+ T + E + +W+ + + ERE L++ + Q+F + FL
Sbjct: 2647 YSADDTRKVHMITENINASWRSIHKRVSEREAALEETH-------RLLQQFPLDLEKFLA 2699
Query: 2172 WI--LETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL------ 2223
W+ ET A L + KE L + K K+ Q ++ ++ D+ NL
Sbjct: 2700 WLTEAETTANVLQDATRKE--RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQK 2757
Query: 2224 --------EDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLE 2257
+DA++L + + +W +L + L ++ +LE
Sbjct: 2758 ILRSLEGSDDAVLLQRRLDNMNF--KWSELRKKSLNIRSHLE 2797
Score = 131 bits (330), Expect = 7e-30
Identities = 300/1619 (18%), Positives = 628/1619 (38%), Gaps = 149/1619 (9%)
Query: 673 LEATKQK--GTQLHEANQQL-QFENNAEDLQRWLEDVEWQVTSE-DYGKGLAEVQNRLRK 728
LEA + K G+ L E+ L +++ E++ WL E + ++ + + V+++
Sbjct: 318 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT 377
Query: 729 HGLLESAVAARQDQVDILTDLAAYF---EEIGHPDSKDIRARQESLVCRFEALKEPLATR 785
H + A Q +V + L + ++ + +++ + L R+E L+ +
Sbjct: 378 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 437
Query: 786 KKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY---LGKDLIASKKLLNRHRVILENI 842
+ L +L + L + ++ W+ +TE LG DL K+ + +H+V+ E++
Sbjct: 438 QSNLHRVL-MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDL 496
Query: 843 ASHEPRIQEITERGNKMVE-EGHFAAEDVASRVKSLNQNMESLRARAARRQNDL-EANVQ 900
+ R+ +T + E G A + ++K L ++ R L + ++
Sbjct: 497 EQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLK 556
Query: 901 FQQYLADLHEAETWIREKEPIVD--NTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKAL 958
+Q+ + W+ EKE V+ +T D+ + L+K DL SM L
Sbjct: 557 WQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 616
Query: 959 RNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMK-KGDVLTLLSSINKDWWKV 1017
+ +Q + ++ + Q+ A D AR + K + + ++ +
Sbjct: 617 ----YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 672
Query: 1018 EAADHQGIVPAVYVR-----RLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAE 1072
V V R + A +E P P +++ RQ ++++ R LD
Sbjct: 673 TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKK--------RQITVDSEIRKRLD--- 721
Query: 1073 ERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVEL------DDVWELQKKFDEFQKD 1126
+ ++ WI +A E + +L++K + +++
Sbjct: 722 ----------------VDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIERE 765
Query: 1127 LNTNEPRLRDINKVA----DDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSA 1182
+L+D ++ A + ++ EG+ Q ++LNSRW +L E+ L
Sbjct: 766 KAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQ 825
Query: 1183 HAVEVFHREADDTKEQIEK-----KCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGD 1237
+ + F+ + ++ K Q + ++P + + S + + L P +
Sbjct: 826 NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP-TAIKSQLKICKDEVNRLSGLQPQIE 884
Query: 1238 KVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSK 1297
++ I + + D + + D+Q R K+ +++ + +
Sbjct: 885 RLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKE-LQTIFDTLPPMRYQET 943
Query: 1298 ARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELID 1357
++ W+ +S +L+ +T EI+ +R E +A + L S + +
Sbjct: 944 MSAIRTWVQQSETKLSIPQLS--VTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE 1001
Query: 1358 SGHHASPEIEKKLQAVKLERDDLEKAWEKR--------KKILDQCLELQMFQGNCDQVES 1409
A EI +K Q+ E +++E W+K +K+ +Q +L+ Q + ++
Sbjct: 1002 MSKKAPSEISRKYQS---EFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKK 1058
Query: 1410 WMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKE 1469
WM A + ++ +L E L K+ ++ + L E ++ A+
Sbjct: 1059 WM-AEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEP 1117
Query: 1470 EIATRLQRVL----DRWKALKAQLIDERTKL-GDYANLKQFYRDLEELEEWISEMLPTAC 1524
E A+RL+ L +W + Q+ + L G +DL E+ EW+++
Sbjct: 1118 EFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYL 1177
Query: 1525 --DESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQL 1582
D YK +Q+ + + E + +V + NS+I A +EA+K++L
Sbjct: 1178 ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVI-AQAPPVAQEALKKEL 1236
Query: 1583 EQLKEHWDHLLERTNDKGKKLNEA--------SRQQRFNTSIRDFEFWLSEAETLLAMKD 1634
E L ++ L R N K K L E S ++ N + + EF L E + +
Sbjct: 1237 ETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE 1296
Query: 1635 QARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK-DNVNK 1693
+ ++ + LE M ED + LA+ L G +D+++ ++ + N
Sbjct: 1297 EISEVLDS---------LENLMRHSEDNPNQIRILAQTLTDGGV--MDELINEELETFNS 1345
Query: 1694 RFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQ--DYGRDLQGVQNL 1751
R+ + E A + L+++ Q Q+ + I+E L + Q Y D +
Sbjct: 1346 RWRELHEEAVRRQKLLEQS---IQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQM 1402
Query: 1752 LKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKAR 1811
++ ++++ +L +HE +++ + K G+E Q L+Q +KL++++
Sbjct: 1403 PQEAQKIQSDLTSHEISLEEM--------KKHNQGKEAAQRVLSQIDVAQKKLQDVS--- 1451
Query: 1812 GLKLEESLEYLQFMQNAEEEEAWINE-KNALAVRGDCGDTLAATQSLLMKHEALENDFAV 1870
+K + F Q +E + ++E K L QS L L +
Sbjct: 1452 -MKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSE 1510
Query: 1871 HETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAF 1930
++ V+ V G I+ K ++ KE+ ++ AL L + K QLE
Sbjct: 1511 VKSEVEMVIKTGRQIVQK--KQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKL 1568
Query: 1931 -QEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEIT 1989
++ + +V+ W+A + L + L Q+ L IT
Sbjct: 1569 SRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSIT 1628
Query: 1990 DLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE---DLFV 2046
++ + L + + +E++ + L W + + LLE Q ++ + D
Sbjct: 1629 EVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1688
Query: 2047 EFAHKASALNNWCEKMEENLSEPV---HCVSLNEIRQLQKDHEDFLASLARAQADFKCLL 2103
++ +A L + EK + E V LN+IR D A+L + D C
Sbjct: 1689 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGD-HCRK 1747
Query: 2104 ELDQQIKALGVPSSPYTW--------LTVEVLERTWKHLSDIIEEREQELQKEEARQVKN 2155
++ QI L + + + ++ LE+ + ++E E E+Q+ + ++
Sbjct: 1748 LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEED 1807
Query: 2156 F--EMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQ 2212
F +M ++ E LQ + D +E + L+ K++++ +R+
Sbjct: 1808 FNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRK 1866
Score = 130 bits (327), Expect = 2e-29
Identities = 396/2157 (18%), Positives = 827/2157 (38%), Gaps = 335/2157 (15%)
Query: 8 TVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYH-LQVFKRDADDLG 66
TV E S E + + Q +E+ R++ ++ E QKLE+ + L+ + L
Sbjct: 998 TVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLK 1057
Query: 67 KWIMEKVNILTDK--SYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHS 124
KW+ E L ++ + D ++ + ++ + L +++QT + L E + +
Sbjct: 1058 KWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQT---IQPSLNSVNEGGQKIKNE 1114
Query: 125 AHEETKAHIE----ELRHLWDLLLELTLEKGDQLLRALKFQQYVQ-ECADILEWIGDKEA 179
A E + +E EL WD + + + + L L+ +Q + +++ EW+ E
Sbjct: 1115 AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE 1174
Query: 180 IATSVELGEDWERTEVLHKKFEDFQ---VELVAKEGRVVEVNQYANECAEENHPDLPLIQ 236
+E +++ + L K E+ + E KE +V + + N + P
Sbjct: 1175 --EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEAL 1232
Query: 237 SKQNEV---NAAW--ERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVL-TSE 290
K+ E N W RL G ++ + L + + +A +W+ E E L T+E
Sbjct: 1233 KKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY---LEKANKWLNEVEFKLKTTE 1289
Query: 291 DYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVS 350
+ +E + LE + D ++ A+ LT D I E E S
Sbjct: 1290 NIPG---GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDE-LINEELETFNS 1345
Query: 351 SWEHIRALATSRY----EKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGE 406
W + A R + +Q+ + E +++++ AA AD++ E
Sbjct: 1346 RWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE 1405
Query: 407 VLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWD 466
+ HEI S +E + N EA+ V ++++ L+
Sbjct: 1406 AQKIQSDLTSHEI--------SLEEMKKH--NQGKEAAQRVLSQIDVAQKK----LQDVS 1451
Query: 467 ERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFT 526
+ R +++ +F ++S+ + + LE + + + ++ L + ++ +
Sbjct: 1452 MKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEV--VQSQLNHCVNLYKSLS 1509
Query: 527 AQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARR---DALREKAATRRRLLKESLL 583
+ ++ V KT +++ +EN K + + + A + + L K R++ L++ L
Sbjct: 1510 EVKSEVEMVIKTGRQIV--QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK 1567
Query: 584 L-QKLYEDSDDLKNWINKKK-KLADDEDYKDI-QNLKSRVQKQQVFEKELAVNKTQLENI 640
L +K+ ++ + L W+ +L + + NL S V + +KE+ K L++I
Sbjct: 1568 LSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI 1627
Query: 641 QKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FENNAEDL 699
+ G+ + V +LS + S W + ++ L E + ++ F+ N + +
Sbjct: 1628 TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHI 1687
Query: 700 QRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAA-YFEEIGH 758
+W+ + + E K + ++ L++ L++ + + +VD D AA G
Sbjct: 1688 TKWIIQAD-TLLDESEKKKPQQKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGD 1743
Query: 759 PDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQET-EPSAT 817
K + + L RF A+ + T K + ++ E + IQ+ EP
Sbjct: 1744 HCRKLVEPQISELNHRFAAISHRIKTGKASIP--------LKELEQFNSDIQKLLEPLEA 1795
Query: 818 STYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEE--GHFAAEDVASRVK 875
G +L ++ N+ + +E ++E+ +RG+ + + E++ + +
Sbjct: 1796 EIQQGVNL--KEEDFNK-----DMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQ 1848
Query: 876 SLNQNMESLR-ARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAA 934
L +L+ R+ RR+ LE + Q+ QY + + + E + + DE
Sbjct: 1849 LLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDE--- 1905
Query: 935 GALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQA------------------------ 970
+K + +L + + A+R QA + A
Sbjct: 1906 ----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQ 1961
Query: 971 ------APVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVE------ 1018
A + V E ++ D P E++ LT ++ +++ +VE
Sbjct: 1962 FRRLNFAQIHTVREETMMVMTEDM----PLEISYVPSTYLTEITHVSQALLEVEQLLNAP 2017
Query: 1019 ---AADHQ--------------------GIVPAVYVRRLA--HDEFPMLPQRRREEPGNI 1053
A D + G + ++ ++ A P+ + +E +
Sbjct: 2018 DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL 2077
Query: 1054 TQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDV 1113
+ E++ Y+ R + R ++++ F Y+ +W+ E + ++ +
Sbjct: 2078 DFQWEKVNKMYKDRQGRFD----RSVEKWRRF--HYDIKIFNQWLTEAEQFLRKTQIPEN 2131
Query: 1114 WELQKK---FDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE----LNSRWG 1166
WE K E Q + + +R +N ++++ + T A I QE LN RW
Sbjct: 2132 WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD--ASILQEKLGSLNLRWQ 2189
Query: 1167 SL-QRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAA-DPGSDLFSVQALQR- 1223
+ ++L+D +++L + + F R+ ++ +E+ S +PG + + L++
Sbjct: 2190 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQV 2249
Query: 1224 --------RHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQ 1275
+G + L G V + + + + + Q ++++ A + Q
Sbjct: 2250 KLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ 2309
Query: 1276 GRTKDRKESLNEAQKFYLFLSKARDLQN-------WISSIGGMVSSQELAEDLTGIEILL 1328
G + + + L + +K K DL+ W+S I +EI
Sbjct: 2310 GEIEAQIKDLGQLEK------KLEDLEEQLNHLLLWLSPIRNQ------------LEIYN 2351
Query: 1329 ERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRK 1388
+ +QE D++ QA + E++ G H E + Q VK + +DL W+
Sbjct: 2352 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE-KPATQPVKRKLEDLSSEWKAVN 2410
Query: 1389 KILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEG 1448
++L + L K+ DL +T
Sbjct: 2411 RLLQE--------------------------------------LRAKQPDLAPGLTTIGA 2432
Query: 1449 KITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRD 1508
T +L+ KE ++L+ + + L+ E L D F R
Sbjct: 2433 SPTQ----TVTLVTQPVVTKETAISKLE--------MPSSLMLEVPALAD------FNRA 2474
Query: 1509 LEELEEWISEMLPTACDESYK--DATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLI 1566
EL +W+S + + D +I +K + +++ R Q+ +I +L
Sbjct: 2475 WTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLK 2534
Query: 1567 ECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEA 1626
++ + +++E+++ WD + E +R+Q+ N ++D WL
Sbjct: 2535 NKTSNQEARTIITDRIERIQNQWDEVQEHLQ---------NRRQQLNEMLKDSTQWLEAK 2585
Query: 1627 ETLLAMKDQARDLASAG-------NLLKKHQLLEREMLARE--------DALKDLN-TLA 1670
E + QAR + + ++K ++ E + LA++ D DL L
Sbjct: 2586 EEAEQVLGQARAKLESWKEGPYTVDAIQK-KITETKQLAKDLRQWQTNVDVANDLALKLL 2644
Query: 1671 EDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQ-DLDDEESWI 1729
D + T V I +N+N + ++ + + L+E + L Q F DL+ +W+
Sbjct: 2645 RDYSADDTRKVHMIT---ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL 2701
Query: 1730 EEKLIRVS-SQDYGR------DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDK 1782
E + QD R D +GV+ L+K+ + L+GE+ AH N+ + ++K+ +
Sbjct: 2702 TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL-R 2760
Query: 1783 AAVGQEE---IQLRLAQFVEHWEKLKELAKARGLKLEESL-EYLQFMQNAEEEEAWINEK 1838
+ G ++ +Q RL W +L++ + LE S ++ + + +E W+ K
Sbjct: 2761 SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 2820
Query: 1839 -NALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQN--------VCAQGEDILNKV 1889
+ L+ + G A Q H A + + E + + + Q + L K+
Sbjct: 2821 DDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKL 2880
Query: 1890 LQE----------ESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDY-AFQEFNWKAD 1938
QE ++ + + + E +N + L A W+ ++++ QE D
Sbjct: 2881 YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 2940
Query: 1939 VVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKL 1995
++ + E G+ +GD L D+L L+ + R EI LK+ +
Sbjct: 2941 ELDLKLRQAEV---IKGSWQPVGDLLI-----DSLQDHLEKVKALR-GEIAPLKENV 2988
Score = 128 bits (321), Expect = 8e-29
Identities = 407/2123 (19%), Positives = 796/2123 (37%), Gaps = 386/2123 (18%)
Query: 5 PKETVVESSGPKVLETAE-----EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQV-F 58
P V G K+ AE ++ +E+ T++ ++V R + L+ V
Sbjct: 1099 PSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSL 1158
Query: 59 KRDADDLGKWIM--EKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKS---RLMSE--- 110
++D ++ +W+ E+ + D Y+ P +Q ++ + + E Q K +L++E
Sbjct: 1159 QKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVN 1218
Query: 111 -------------LEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELT--LEKGDQLL 155
L+K E T + L +W EL LEK ++ L
Sbjct: 1219 SVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWL 1278
Query: 156 RALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAK---EG 212
++F+ E G E I+ ++ E+ R H + Q+ ++A+ +G
Sbjct: 1279 NEVEFKLKTTENIP-----GGAEEISEVLDSLENLMR----HSEDNPNQIRILAQTLTDG 1329
Query: 213 RVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRD 272
V++ LI + N+ W L A++RQK L
Sbjct: 1330 GVMD----------------ELINEELETFNSRWRELHEEAVRRQKLLE----------- 1362
Query: 273 VTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKV--KELCAKAEKL 330
++IQ +E E L + E L K L A ++DKV ++ +A+K+
Sbjct: 1363 --QSIQSAQETEKSLH--------LIQESLTFIDKQL---AAYIADKVDAAQMPQEAQKI 1409
Query: 331 TLSHPSDAPQIQEMKEDLVSSWEHIRAL-----ATSRYEKLQATYWYHRFSSDFDE--LS 383
S ++EMK+ R L A + + + + + ++F++
Sbjct: 1410 QSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQE 1469
Query: 384 GWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADE------TGQDLV 437
M ++ L T EV+ Q H ++ Y + E TG+ +V
Sbjct: 1470 SKMILDEVKMHLPALETKSVEQEVV---QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV 1526
Query: 438 NANH-EASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQE 496
E E+ E++ L ++ L ER +Q E+CL S ++ M+
Sbjct: 1527 QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKL------SRKMRKEMNVLT 1580
Query: 497 AFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAI 556
+L D+ + SA + + D E A+ +K I K K I + + +
Sbjct: 1581 EWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK 1640
Query: 557 RDGLLARRDALREK---AATRRR------LLKESLLLQKLYEDSDDLKNWINKKKKLADD 607
++ L+ + +L A T R LL+ ++ ++ D + WI + L D+
Sbjct: 1641 KETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDE 1700
Query: 608 EDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQE----MIEGGHYASDNVTTRLS 663
+ K Q QK+ V ++ A + T + M G + V ++S
Sbjct: 1701 SEKKKPQ------QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQIS 1754
Query: 664 EVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQV------TSEDYGK 717
E+ + + K + + E D+Q+ LE +E ++ ED+ K
Sbjct: 1755 ELNHRFAAISHRIKTGKASI----PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK 1810
Query: 718 GLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEA 777
+ E G ++ + + +TD ++I+ +Q+ L + A
Sbjct: 1811 DMNE-----DNEGTVKELLQRGDNLQQRITD---------ERKREEIKIKQQLLQTKHNA 1856
Query: 778 LKEPLATRKKKLLDLLH-LQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHR 836
LK+ + R+KK L++ H R +D + + E S +D K++
Sbjct: 1857 LKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI----- 1911
Query: 837 VILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE 896
+ +Q+ E N + + +ED A+ +E + + ++R ++E
Sbjct: 1912 ---------DRELQKKKEELNAVRRQAEGLSEDGAAMA------VEPTQIQLSKRWREIE 1956
Query: 897 AN-VQFQQY-LADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDS 954
+ QF++ A +H +RE+ +V E+ + +L ++ +
Sbjct: 1957 SKFAQFRRLNFAQIHT----VREETMMV------MTEDMPLEISYVPSTYLTEITHVSQA 2006
Query: 955 MKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDW 1014
+ + NA + DF+ +E ++K
Sbjct: 2007 LLEVEQLLNAPD----------------LCAKDFEDLFKQEESLKN-------------- 2036
Query: 1015 WKVEAADHQGIVPAVYVRRLA--HDEFPMLPQRRREEPGNITQRQEQIENQYR---SLLD 1069
K G + ++ ++ A P+ + +E + + E++ Y+ D
Sbjct: 2037 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2096
Query: 1070 RAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQK---KFDEFQKD 1126
R+ E+ RR Y+ +W+ E + ++ + WE K E Q
Sbjct: 2097 RSVEKWRR---------FHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDG 2147
Query: 1127 LNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE----LNSRWGSL-QRLADEQRQLLGS 1181
+ + +R +N ++++ + T A I QE LN RW + ++L+D +++L
Sbjct: 2148 IGQRQTVVRTLNATGEEIIQQSSKT--DASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQ 2205
Query: 1182 AHAVEVFHREADDTKEQIEKKCQALS-AADPGSDLFSVQALQR---------RHEGFERD 1231
+ + F R+ ++ +E+ S +PG + + L++ +G +
Sbjct: 2206 KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQ 2265
Query: 1232 LVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKF 1291
L G V + + + + + Q ++++ A + QG + + + L + +K
Sbjct: 2266 LNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEK- 2324
Query: 1292 YLFLSKARDLQN-------WISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPT 1344
K DL+ W+S I +EI + +QE D++
Sbjct: 2325 -----KLEDLEEQLNHLLLWLSPIRNQ------------LEIYNQPNQEGPFDVQETEIA 2367
Query: 1345 FQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQ--MFQG 1402
QA + E++ G H E + Q VK + +DL W+ ++L + Q + G
Sbjct: 2368 VQAKQPDVEEILSKGQHLYKE-KPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPG 2426
Query: 1403 ----------NCDQVESWMVARENSLRSDDKSS----------------------LDSLE 1430
V +V +E ++ + S L L+
Sbjct: 2427 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD 2486
Query: 1431 ALMKKR-------DDLDKAITAQEGKITDLEH---FAESLI---------ADEHYAKEEI 1471
++K + +D+++ I Q+ + DLE E LI A+ I
Sbjct: 2487 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII 2546
Query: 1472 ATRLQRVLDRWKALKAQLIDERTKLGD-YANLKQFYRDLEELEEWISEMLPTACDESYKD 1530
R++R+ ++W ++ L + R +L + + Q+ EE E+ + + A ES+K+
Sbjct: 2547 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQ--ARAKLESWKE 2604
Query: 1531 ----ATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLK 1586
IQ+K + + A ++ V +L L+ + D + + E +
Sbjct: 2605 GPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRK-VHMITENIN 2663
Query: 1587 EHWDHLLERTNDKGKKLNEASR-QQRFNTSIRDFEFWLSEAETLL-AMKDQAR------D 1638
W + +R +++ L E R Q+F + F WL+EAET ++D R D
Sbjct: 2664 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLED 2723
Query: 1639 LASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSS--GTFNVDQIVKKKDNVN---- 1692
L+K+ Q L+ E+ A D +L+ ++ +L S G+ + + ++ DN+N
Sbjct: 2724 SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWS 2783
Query: 1693 ---KRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQ-DYGRDLQGV 1748
K+ LN++ A ++ K + L + W++ K +S Q G D V
Sbjct: 2784 ELRKKSLNIRSHLEASSDQWKRLHL------SLQELLVWLQLKDDELSRQAPIGGDFPAV 2837
Query: 1749 QNLLKKHKRLEGELVAHEPAIQNVLDMA------------EKL---------KDKAAVGQ 1787
Q H+ + EL EP I + L+ EKL +++A
Sbjct: 2838 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 2897
Query: 1788 EEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGD- 1846
++ + + WEKL + K++E+LE LQ +Q A +E + + A ++G
Sbjct: 2898 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA-TDELDLKLRQAEVIKGSW 2956
Query: 1847 --CGDTLA-ATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKI 1903
GD L + Q L K +AL + A + V +V + +Q N S +
Sbjct: 2957 QPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN---LSTL 3013
Query: 1904 EALNEKTPSLAKAIAAWKLQLED 1926
E LN + L A+ QL +
Sbjct: 3014 EDLNTRWKLLQVAVEDRVRQLHE 3036
Score = 115 bits (287), Expect = 7e-25
Identities = 385/2188 (17%), Positives = 838/2188 (38%), Gaps = 305/2188 (13%)
Query: 260 LSNAANLQRFKRDVTEAIQWIKEKEPVLTSE-DYGKDLVASEGLFHSHKGLERNLAVMSD 318
+ + NL R++ + E + W+ E L ++ + D+ + FH+H+G +L
Sbjct: 331 MESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQG 390
Query: 319 KVKELCAKAEKL----TLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHR 374
+V + KL LS + ++QE L S WE +R + + L HR
Sbjct: 391 RVGNILQLGSKLIGTGKLSEDEET-EVQEQMNLLNSRWECLRVASMEKQSNL------HR 443
Query: 375 FSSDFD-----ELSGW----------MNEKTAAINADELPTDVAGGEVLLDRHQQHKHEI 419
D EL+ W M E+ + ++L V +VL + +Q + +
Sbjct: 444 VLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 503
Query: 420 DSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQ-CLDF 478
+S DE+ D A+ + E++++L + W + ++R + L +
Sbjct: 504 NSLTHMVVVVDESSGD------HATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKW 557
Query: 479 HLFYRDSEQVDSWMSRQE---------AFLENEDLGNSLGSAEALL----QKHEDFEEAF 525
+ +W+S +E F + ++ +SL L +K + + +
Sbjct: 558 QRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLY 617
Query: 526 TAQEEKIITV--------------------DKTATKLIGDDHYDSENIKAIRDGL----- 560
+ +++ + T+ D KL S+ + + L
Sbjct: 618 SLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTV 677
Query: 561 ------LARRDALREKAA----------TRRRLLKESLLLQKLYEDSDDLKNWINKKKKL 604
+ R+ + K A +R++ +S + ++L D +L +WI + + +
Sbjct: 678 METVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAV 737
Query: 605 ADDEDYKDIQ---NLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIE---GGHYASDNV 658
++ + N +K E+E A +L++ ++ Q ++E +D++
Sbjct: 738 LQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSI 797
Query: 659 TTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVE-WQVTSEDYGK 717
++ S W E + ++ L N + F N + L++ E W
Sbjct: 798 KQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 857
Query: 718 GLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEA 777
++++L+ + ++ Q Q++ L + +E G + A + F+
Sbjct: 858 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQ-GPMFLDADFVAFTNHFKQ 916
Query: 778 LKEPLATRKKKLLDLLHLQLICRDTEDEEA---WIQETEPSATSTYLG-KDLIASKKLLN 833
+ + R+K+L + R E A W+Q++E + L D ++ L
Sbjct: 917 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 976
Query: 834 RHRVILENIASHE-------PRIQEITERGNKMVEEGHFAA-EDVASRVKSLNQNMESLR 885
+ + ++ + ++E++++ + + + E++ R K L+ +
Sbjct: 977 ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHC 1036
Query: 886 ARAARRQNDLEANVQFQQYLAD-LHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAF 944
+ + N L Q L + E + +++E+ P + D E LK+
Sbjct: 1037 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPAL------GDSEILKKQLKQCRLL 1090
Query: 945 LLDLNSFGDSMKALRNQA----NACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKK 1000
+ D+ + S+ ++ N + + A+ +E E + Q R+ +K
Sbjct: 1091 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1150
Query: 1001 GDVLTLLSSINKDW-----WKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQ 1055
G L S+ KD W +A + Y+ R + P Q+ EE +
Sbjct: 1151 G--LEKTVSLQKDLSEMHEWMTQAEEE-------YLERDFEYKTPDELQKAVEEMKRAKE 1201
Query: 1056 RQEQIENQYR-------SLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGV 1108
+Q E + + S++ +A + L++ E L +W+ +
Sbjct: 1202 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTT-----NYQWLC-TRLNGKCK 1255
Query: 1109 ELDDVW----ELQKKFDEFQKDLNTNEPRLR----------DINKVADDLLFEGLL---- 1150
L++VW EL ++ K LN E +L+ +I++V D L E L+
Sbjct: 1256 TLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSL--ENLMRHSE 1313
Query: 1151 -TPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAA 1209
P +I + + G + L +E+ + S H EA ++ +E+ Q+
Sbjct: 1314 DNPNQIRILAQTLTDGGVMDELINEELETFNSRW--RELHEEAVRRQKLLEQSIQSAQET 1371
Query: 1210 DPGSDLFSVQALQRRHEGFERDLVP-LGDKVTI--LGETAERLSE---SHPDATEDLQRQ 1263
+ S+ +Q ++ L + DKV + + A+++ SH + E++++
Sbjct: 1372 EK-----SLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKH 1426
Query: 1264 KMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTG 1323
A L +K+ + + KF LF A Q S + E+ L
Sbjct: 1427 NQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES---KMILDEVKMHLPA 1483
Query: 1324 IEILLERHQEHRADMEAEAPTFQALEDFSAE---LIDSGHHA--------SPEIEKKLQA 1372
+E + ++ + +++L + +E +I +G E+++++ A
Sbjct: 1484 LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTA 1543
Query: 1373 VKLERDDLEKAWEKRKKILDQCLEL-QMFQGNCDQVESWMVARENSL--RSDDKSSLDSL 1429
+KL ++L +RK+ L++CL+L + + + + W+ A + L RS + +L
Sbjct: 1544 LKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNL 1603
Query: 1430 EALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQL 1489
++ + K I Q+ + + E+L + + +L + W A+ ++
Sbjct: 1604 DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 1663
Query: 1490 IDERTKLGDY-ANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKH-----QT 1543
+ L +Y +++ F ++++ + +WI + T DES K + LK
Sbjct: 1664 EEWLNLLLEYQKHMETFDQNVDHITKWIIQ-ADTLLDESEKKKPQQKEDVLKRLKAELND 1722
Query: 1544 FAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKL 1603
+VD +Q ++ + D + ++ Q+ +L + + R GK
Sbjct: 1723 IRPKVDSTRDQAANLM--------ANRGDHCRKLVEPQISELNHRFAAISHRIK-TGKAS 1773
Query: 1604 NEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDAL 1663
++FN+ I+ L EAE + + D N + ++ +E+L R D L
Sbjct: 1774 IPLKELEQFNSDIQKLLEPL-EAEIQQGVNLKEEDFNKDMN--EDNEGTVKELLQRGDNL 1830
Query: 1664 KDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEK-LKEAYALFQFFQDL 1722
+ + ++ Q+++ K N +++L + +K L+ ++ +Q+ +
Sbjct: 1831 Q--QRITDERKREEIKIKQQLLQTKHNA------LKDLRSQRRKKALEISHQWYQYKRQA 1882
Query: 1723 DDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL-KD 1781
DD +++ +++S RD +K K ++ EL + + V AE L +D
Sbjct: 1883 DDLLKCLDDIEKKLASLPEPRD-------ERKIKEIDRELQKKKEELNAVRRQAEGLSED 1935
Query: 1782 KAAVGQEEIQLRLAQFVEHWEKLK-ELAKARGLKLEE----SLEYLQFMQNAEEEEAWIN 1836
AA+ E Q++L+ + W +++ + A+ R L + E + M E
Sbjct: 1936 GAAMAVEPTQIQLS---KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYV 1992
Query: 1837 EKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILN--KVLQEES 1894
L L + LL + DF +++ Q E + N LQ+ S
Sbjct: 1993 PSTYLTEITHVSQALLEVEQLLNAPDLCAKDF-------EDLFKQEESLKNIKDSLQQSS 2045
Query: 1895 QNKEI--SSKIEALNEKTP----SLAKAIAAWKLQLE---------------DDYAFQEF 1933
+I S K AL TP L +A++ Q E ++ F
Sbjct: 2046 GRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRF 2105
Query: 1934 NWKADVVEAWIADKE-----TSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEI 1988
++ + W+ + E T + N A +L L QD + Q++ +
Sbjct: 2106 HYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKEL--QDGIG------QRQTVVRT 2157
Query: 1989 TDLKDKLISAQHNQSKA--IEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFV 2046
+ + I Q +++ A ++E+ +L RW+++ ++L +++ L++ +++
Sbjct: 2158 LNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC-------KQLSDRKKRLEEQKNILS 2210
Query: 2047 EFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELD 2106
EF + W E+ + S P+ ++++ + + + L Q K L E
Sbjct: 2211 EFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETG 2270
Query: 2107 QQIKALGVPSSPYTWLTVE-VLERT---WKHLSDIIEEREQELQKEEARQVKNFEMCQEF 2162
+ + P SP +E L++T W +S + E++ E++ + + + ++
Sbjct: 2271 GPV-LVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDL 2329
Query: 2163 EQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDN 2222
E+ + L W+ R + + G + Q + +QA + + +I+ G +
Sbjct: 2330 EEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ-----ETEIAVQAKQPDVEEILSKGQH 2384
Query: 2223 L--EDALILDIKYSTIGLAQQWDQLYQL 2248
L E +K L+ +W + +L
Sbjct: 2385 LYKEKPATQPVKRKLEDLSSEWKAVNRL 2412
Score = 80.9 bits (198), Expect = 1e-14
Identities = 206/1124 (18%), Positives = 426/1124 (37%), Gaps = 169/1124 (15%)
Query: 1225 HEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKES 1284
H+G +++ LG K+ G+ +E D ++Q Q LN WE L+ + +++ +
Sbjct: 388 HQGRVGNILQLGSKLIGTGKLSE-------DEETEVQEQMNLLNSRWECLRVASMEKQSN 440
Query: 1285 LNEAQKFYLFLSKARDLQNWISSIGGMVSSQE---LAEDLTGIEILLERHQEHRADMEAE 1341
L+ L K ++L +W++ E L DL ++ +++H+ + D+E E
Sbjct: 441 LHRVL-MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQE 499
Query: 1342 APTFQALEDFSAELIDS-GHHASPEIEKKLQAVKLERDDLEKAWEKRKKIL-DQCLELQM 1399
+L + +S G HA+ +E++L+ + ++ + E R +L D L+ Q
Sbjct: 500 QVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQR 559
Query: 1400 FQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAES 1459
+W+ +E+++ +
Sbjct: 560 LTEEQCLFSAWLSEKEDAVNKIHTTGFKD------------------------------- 588
Query: 1460 LIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEM 1519
+ E+ + LQ++ LKA L ++ +G +LKQ +L +
Sbjct: 589 --------QNEMLSSLQKLA----VLKADLEKKKQSMGKLYSLKQ------DLLSTLKNK 630
Query: 1520 LPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQV-HGVINLGNSLIECSACDGNEEAM 1578
T E++ D N R + +++ + Q+ V SL + + +
Sbjct: 631 SVTQKTEAWLD--NFARCW---DNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 685
Query: 1579 KEQLEQLKEHWDHLLERTNDKGKKLNEASR-QQRFNTSIRDFEFWLSEAETLLAMKDQA- 1636
+ +K + L K +++ S ++R + I + W++ +E +L + A
Sbjct: 686 TREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAI 745
Query: 1637 -RDLASAGNLLKKHQLLEREMLAR----EDALKDLNTLAEDLLSSGTFNVDQIVKKKDNV 1691
R + +L +K +ERE + +DA + L E +++ G N D I + + +
Sbjct: 746 FRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV-NADSIKQASEQL 804
Query: 1692 NKRFLNVQELAAAHHEKLKEAYALFQFFQDLDD-------EESWIEEKLIRVSSQDYGRD 1744
N R++ +L + L+ + F+ L E+W++ + S
Sbjct: 805 NSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT---- 860
Query: 1745 LQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKL 1804
+++ LK K L +P I+ + + LK+K G + F H++++
Sbjct: 861 --AIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQ-GPMFLDADFVAFTNHFKQV 917
Query: 1805 KELAKARGLKLE---ESLEYLQFMQNAEEEEAWINEKNA-LAVRGDCGDTLAATQSLLMK 1860
+AR +L+ ++L +++ + W+ + L++ + L +
Sbjct: 918 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 977
Query: 1861 HEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAW 1920
+AL++ ++ + + +++ K E S ++ S+ E + + L+ +
Sbjct: 978 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS--RKYQSEFEEIEGRWKKLSSQLVEH 1035
Query: 1921 KLQLEDDY-AFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQS 1979
+LE+ ++ ++ W+A+ + LK + L KQ L S
Sbjct: 1036 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1095
Query: 1980 FQQERLPEITDLKDKLIS-AQHNQSKAIEERYAALLKRWEQLLEASAVHRQKL---LEKQ 2035
Q L + + K+ + A+ + +E L +W+ + + ++ L LEK
Sbjct: 1096 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1155
Query: 2036 LPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARA 2095
+ LQK DL S ++ W + EE E +LQK E+ + A
Sbjct: 1156 VSLQK--DL--------SEMHEWMTQAEEEYLE--RDFEYKTPDELQKAVEEMKRAKEEA 1203
Query: 2096 Q---ADFKCLLELDQQIKALGVP-------------SSPYTWL---------TVEVLERT 2130
Q A K L E + A P ++ Y WL T+E +
Sbjct: 1204 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1263
Query: 2131 WKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETG 2190
W L +E+ + L + E + +K E + S L
Sbjct: 1264 WHELLSYLEKANKWLNEVEFK-LKTTENIPGGAEEISEVLD------------------- 1303
Query: 2191 TLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGL 2250
+LE+ + ++ +I+ + + LT + D LI + + T +W +L++ +
Sbjct: 1304 SLENLMRHSEDNPNQIRILAQTLTD-----GGVMDELINE-ELETFN--SRWRELHEEAV 1355
Query: 2251 RMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHK 2294
R Q LEQ IQ+ S ++E T D+ L + K
Sbjct: 1356 RRQKLLEQSIQSAQETEKSLHLIQESLTF---IDKQLAAYIADK 1396
Score = 77.8 bits (190), Expect = 1e-13
Identities = 332/1839 (18%), Positives = 699/1839 (38%), Gaps = 277/1839 (15%)
Query: 18 LETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD--LGKWIMEKVNI 75
LET E R Q E+ + Q+ E S HL D L +I +KV+
Sbjct: 1340 LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD- 1398
Query: 76 LTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEE 135
+ + P Q+ Q +++++ + + E++K + G A + + I+
Sbjct: 1399 ----AAQMP-------QEAQKIQSDLTSHEISLEEMKKHNQ-----GKEAAQRVLSQIDV 1442
Query: 136 L-RHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTE 194
+ L D+ ++ L + + F+Q +QE IL+ + + + ++ +++
Sbjct: 1443 AQKKLQDVSMKFRLFQ-----KPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ 1497
Query: 195 V-----LHKKFEDF--QVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWE 247
+ L+K + +VE+V K GR + V + E +E + ++ NE+ A
Sbjct: 1498 LNHCVNLYKSLSEVKSEVEMVIKTGRQI-VQKKQTENPKELDERVTALKLHYNELGAK-- 1554
Query: 248 RLRGLALQRQKALSNAANLQR-FKRDVTEAIQWIKEKEPVLTSEDYGKDLVAS-EGLFHS 305
+R++ L L R ++++ +W+ + LT + + ++ +
Sbjct: 1555 -----VTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAW 1609
Query: 306 HKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEK 365
K ++ + +K + E L +++ L S+W + + A +
Sbjct: 1610 GKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA-EEWLN 1668
Query: 366 LQATYWYHR--FSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYD 423
L Y H F + D ++ W+ + ++ E +VL ++ K E++
Sbjct: 1669 LLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL----KRLKAELNDIR 1724
Query: 424 DRFQSA-DETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFY 482
+ S D+ + N V ++ L++ + A+ HR L
Sbjct: 1725 PKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAI------SHRIKTGKASIPL-- 1776
Query: 483 RDSEQVDSWMSR----------QEAFLENEDLGNSL-----GSAEALLQKHEDFEEAFTA 527
++ EQ +S + + Q L+ ED + G+ + LLQ+ ++ ++ T
Sbjct: 1777 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD 1836
Query: 528 QEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALRE-KAATRRRLLKESLLLQK 586
+ ++ E IK + L + +AL++ ++ R++ L+ S +
Sbjct: 1837 ERKR-------------------EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1877
Query: 587 LYEDSDDLKNWINK-KKKLADDEDYKDIQNLKSRVQKQQVFEKEL--------------- 630
+DDL ++ +KKLA + +D + +K ++ Q ++EL
Sbjct: 1878 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1937
Query: 631 --AVNKTQLENIQKTGQEMIEGGHYASDNV----TTRLSEVASLWEEL-LEATKQKGTQL 683
AV TQ++ ++ + + + N T R + + E++ LE + T L
Sbjct: 1938 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1997
Query: 684 ----HEANQQLQFEN--NAEDL-QRWLEDVEWQVTS-EDYGKGLAEVQNRL-----RKHG 730
H + L+ E NA DL + ED+ Q S ++ L + R+ +K
Sbjct: 1998 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2057
Query: 731 LLESAVAARQDQV-DILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKL 789
L+SA + ++ + L+ L +E++ KD + R + V ++ + + L
Sbjct: 2058 ALQSATPVERVKLQEALSQLDFQWEKVNKM-YKDRQGRFDRSVEKWRRFHYDIKIFNQWL 2116
Query: 790 LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849
+ + R T+ E W E + YL + + + I + +
Sbjct: 2117 TEA---EQFLRKTQIPENW----EHAKYKWYL--------------KELQDGIGQRQTVV 2155
Query: 850 QEITERGNKMVEEGHFA-AEDVASRVKSLNQNMESLRARAARRQNDLEANVQF-QQYLAD 907
+ + G +++++ A + ++ SLN + + + + R+ LE ++ D
Sbjct: 2156 RTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRD 2215
Query: 908 LHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQAN-ACQ 966
L+E W+ E + I E+ L++ + + +L +K L
Sbjct: 2216 LNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV 2275
Query: 967 QQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIV 1026
+P E E ++ + R + K+G++ + + + K+E + Q
Sbjct: 2276 SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ--- 2332
Query: 1027 PAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFL 1086
L H + P R + E N ++ + Q + +A++ + + L
Sbjct: 2333 -------LNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHL 2385
Query: 1087 LAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLF 1146
Y+ + ++ +K E+ E V L ++ Q DL + L+
Sbjct: 2386 --YKEKPATQPVK-RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 2442
Query: 1147 EGLLTPEGAQIRQEL--------------NSRWGSL-------QRLADEQRQLLGSAHAV 1185
+ ++T E A + E+ N W L ++ QR ++G +
Sbjct: 2443 QPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDI 2502
Query: 1186 EVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGET 1245
+ T + +E++ L + + Q L+ + E TI+ +
Sbjct: 2503 NEMIIKQKATMQDLEQRRPQLEEL-----ITAAQNLKNKTSNQEAR--------TIITDR 2549
Query: 1246 AERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKAR-DLQNW 1304
ER+ + E LQ ++ +LNE KD + L ++ L +AR L++W
Sbjct: 2550 IERIQNQWDEVQEHLQNRRQQLNE-------MLKDSTQWLEAKEEAEQVLGQARAKLESW 2602
Query: 1305 ------ISSIGGMVS-SQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELID 1357
+ +I ++ +++LA+DL R + D+ A + L D+SA+
Sbjct: 2603 KEGPYTVDAIQKKITETKQLAKDL--------RQWQTNVDV-ANDLALKLLRDYSADDTR 2653
Query: 1358 SGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQC-LELQMFQGNCDQVESWM----- 1411
H + I +++ + E A E+ ++L Q L+L+ F + E+
Sbjct: 2654 KVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQD 2713
Query: 1412 VARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEI 1471
R+ L D K ++ LMK+ DL I A +L+ ++ ++ + +
Sbjct: 2714 ATRKERLLEDSK----GVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD-- 2767
Query: 1472 ATRLQRVLD----RWKALKAQLIDERTKL-GDYANLKQFYRDLEELEEW-------ISEM 1519
A LQR LD +W L+ + ++ R+ L K+ + L+EL W +S
Sbjct: 2768 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2827
Query: 1520 LPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE--- 1576
P D +Q++ H+ F E+ + + + + +G E+
Sbjct: 2828 APIG-----GDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2882
Query: 1577 ----------------AMKEQLEQLKEHWDHLLERTNDKGKKLNEA-SRQQRFNTSIRDF 1619
+++Q E++ W+ L + D +K++E R Q + +
Sbjct: 2883 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 2942
Query: 1620 EFWLSEAETLLAMKDQARDLA--SAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSG 1677
+ L +AE + DL S + L+K + L E+ ++ + +N LA L + G
Sbjct: 2943 DLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLG 3002
Query: 1678 TFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF 1716
+ +++N R+ +Q +L EA+ F
Sbjct: 3003 IQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDF 3041
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,263,815
Number of Sequences: 37866
Number of extensions: 3782949
Number of successful extensions: 20811
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 215
Number of HSP's successfully gapped in prelim test: 681
Number of HSP's that attempted gapping in prelim test: 12161
Number of HSP's gapped (non-prelim): 4768
length of query: 2419
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2300
effective length of database: 13,741,464
effective search space: 31605367200
effective search space used: 31605367200
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.