Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 219842214
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|219842214 protein phosphatase 1, regulatory (inhibitor)
subunit 12A isoform b [Homo sapiens]
(943 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|219842214 protein phosphatase 1, regulatory (inhibitor) subun... 1831 0.0
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun... 1831 0.0
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit... 1831 0.0
gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit... 758 0.0
gi|14195601 protein phosphatase 1, regulatory (inhibitor) subuni... 729 0.0
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ... 295 1e-79
gi|14195597 protein phosphatase 1, regulatory (inhibitor) subuni... 194 4e-49
gi|14195599 protein phosphatase 1, regulatory (inhibitor) subuni... 165 2e-40
gi|14249672 protein phosphatase 1, regulatory (inhibitor) subuni... 150 5e-36
gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 1... 142 2e-33
gi|62177127 myosin heavy chain Myr 8 [Homo sapiens] 117 4e-26
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 94 6e-19
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 94 6e-19
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 91 4e-18
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 90 9e-18
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 89 3e-17
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 88 3e-17
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 88 3e-17
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 88 3e-17
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 88 3e-17
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 88 4e-17
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 87 1e-16
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 86 2e-16
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 86 2e-16
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 86 2e-16
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 86 2e-16
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 82 2e-15
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 82 2e-15
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 82 2e-15
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 82 2e-15
>gi|219842214 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform b [Homo sapiens]
Length = 943
Score = 1831 bits (4742), Expect = 0.0
Identities = 943/943 (100%), Positives = 943/943 (100%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE
Sbjct: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA
Sbjct: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT
Sbjct: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
Query: 181 AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP 240
AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP
Sbjct: 181 AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP 240
Query: 241 EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSS 300
EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSS
Sbjct: 241 EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSS 300
Query: 301 TQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG 360
TQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG
Sbjct: 301 TQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG 360
Query: 361 ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLAS 420
ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLAS
Sbjct: 361 ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLAS 420
Query: 421 TSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSV 480
TSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSV
Sbjct: 421 TSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSV 480
Query: 481 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP 540
PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP
Sbjct: 481 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP 540
Query: 541 TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR 600
TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR
Sbjct: 541 TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR 600
Query: 601 QARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESE 660
QARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESE
Sbjct: 601 QARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESE 660
Query: 661 TSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGIT 720
TSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGIT
Sbjct: 661 TSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGIT 720
Query: 721 SAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQ 780
SAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQ
Sbjct: 721 SAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQ 780
Query: 781 EQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKD 840
EQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKD
Sbjct: 781 EQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKD 840
Query: 841 DSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRER 900
DSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRER
Sbjct: 841 DSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRER 900
Query: 901 RALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK 943
RALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK
Sbjct: 901 RALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK 943
>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 1831 bits (4742), Expect = 0.0
Identities = 943/943 (100%), Positives = 943/943 (100%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE
Sbjct: 88 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 147
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA
Sbjct: 148 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 207
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT
Sbjct: 208 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 267
Query: 181 AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP 240
AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP
Sbjct: 268 AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP 327
Query: 241 EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSS 300
EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSS
Sbjct: 328 EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSS 387
Query: 301 TQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG 360
TQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG
Sbjct: 388 TQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG 447
Query: 361 ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLAS 420
ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLAS
Sbjct: 448 ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLAS 507
Query: 421 TSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSV 480
TSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSV
Sbjct: 508 TSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSV 567
Query: 481 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP 540
PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP
Sbjct: 568 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP 627
Query: 541 TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR 600
TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR
Sbjct: 628 TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR 687
Query: 601 QARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESE 660
QARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESE
Sbjct: 688 QARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESE 747
Query: 661 TSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGIT 720
TSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGIT
Sbjct: 748 TSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGIT 807
Query: 721 SAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQ 780
SAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQ
Sbjct: 808 SAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQ 867
Query: 781 EQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKD 840
EQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKD
Sbjct: 868 EQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKD 927
Query: 841 DSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRER 900
DSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRER
Sbjct: 928 DSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRER 987
Query: 901 RALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK 943
RALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK
Sbjct: 988 RALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK 1030
>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit 12A
isoform a [Homo sapiens]
Length = 1030
Score = 1831 bits (4742), Expect = 0.0
Identities = 943/943 (100%), Positives = 943/943 (100%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE
Sbjct: 88 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 147
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA
Sbjct: 148 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 207
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT
Sbjct: 208 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 267
Query: 181 AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP 240
AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP
Sbjct: 268 AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP 327
Query: 241 EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSS 300
EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSS
Sbjct: 328 EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSS 387
Query: 301 TQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG 360
TQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG
Sbjct: 388 TQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG 447
Query: 361 ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLAS 420
ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLAS
Sbjct: 448 ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLAS 507
Query: 421 TSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSV 480
TSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSV
Sbjct: 508 TSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSV 567
Query: 481 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP 540
PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP
Sbjct: 568 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP 627
Query: 541 TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR 600
TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR
Sbjct: 628 TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR 687
Query: 601 QARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESE 660
QARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESE
Sbjct: 688 QARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESE 747
Query: 661 TSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGIT 720
TSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGIT
Sbjct: 748 TSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGIT 807
Query: 721 SAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQ 780
SAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQ
Sbjct: 808 SAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQ 867
Query: 781 EQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKD 840
EQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKD
Sbjct: 868 EQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKD 927
Query: 841 DSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRER 900
DSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRER
Sbjct: 928 DSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRER 987
Query: 901 RALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK 943
RALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK
Sbjct: 988 RALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK 1030
>gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform a [Homo sapiens]
Length = 982
Score = 758 bits (1958), Expect = 0.0
Identities = 460/962 (47%), Positives = 609/962 (63%), Gaps = 104/962 (10%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MVKFLVEN AN+NQ DNEGW PLHAAASCGYL+IAE+ I GA VG VNSEG+ P D+AE
Sbjct: 106 MVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAE 165
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
E AM++LL +V +QG+D+E +RKEEE+ ML+DARQWLNSG I DVR A+SG TALHVAA
Sbjct: 166 EPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAA 225
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
AKGY+EVL+LLIQAGY++N++DYDGWTPLHAAAHWG +EAC IL + LCDM++ NK+GQT
Sbjct: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
Query: 181 AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP 240
FDVADE ++ +LE LQKKQN+L SEK + ++ LIES ++++ FKNKE ++ E
Sbjct: 286 PFDVADEGLVEHLELLQKKQNVLRSEK-ETRNKLIES--DLNSKIQSGFFKNKEKMLYEE 342
Query: 241 EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDK---TKPLASVTNAN 297
E K E EE K+ SS SSEE+E +D SE+ET+K KP A V ++N
Sbjct: 343 ----------ETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSN 392
Query: 298 TSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTG 357
+ S + + P ++ A S ++F ++ + K EE KDESP++WRLGLRKTG
Sbjct: 393 SESKSSITEQIPAPAQNTFSA---SSARRF---SSGLFNKPEEPKDESPSSWRLGLRKTG 446
Query: 358 SYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRR 417
S+ L+E+ S+E +++ ++ + RS+SSPR+S+ LDNK+KE+++K +Y++ PR+
Sbjct: 447 SHNMLSEVANSREPIRDRGSS-IYRSSSSPRISALLDNKDKERENK----SYISSLAPRK 501
Query: 418 LASTSDIEEKENRDSS-SLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLI 476
L STSDIEEKENR+S+ +L S SYTR+ W D+ K N
Sbjct: 502 LNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGN----------------------- 538
Query: 477 SSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEK 536
+P T + T ST K T S A T AE + +
Sbjct: 539 --EIPQTIAPSTY-------------VSTYLKRTPHKSQADTT--------AEKTADNVS 575
Query: 537 DSVPTAV-TIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQR 595
S P V T P+ N +T L+ T GT S+ E RE+RRSYLTPVRDEE+ES R
Sbjct: 576 SSTPLCVITNRPLPSTANGVTATPVLSIT--GT-DSSVEAREKRRSYLTPVRDEEAESLR 632
Query: 596 KARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEE 655
KARSRQARQ+RRSTQGVTLTDLQEAE+T RSR+ R +++ EK + + + ++ E
Sbjct: 633 KARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLEGSPEKHE 692
Query: 656 KKESETSREDEYKQKYSRTYDETYQRYR---PVSTSSSTTPSSSLSTMSSSLYASSQL-- 710
+ E +Q + R+ DE +R P TTP+S ST SLY SS L
Sbjct: 693 PSAVPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASP-STSRPSLYTSSHLLW 751
Query: 711 -NRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVS 769
NR + +S + T E + + EE E S+ SIRERRRP+E+RR TG++
Sbjct: 752 TNRFSVPDSESSETTTNTTTAKEMDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGIN 811
Query: 770 FWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYE------TSSTSAGDRYDSLLGRSGS 823
FWT+D DE T+ KET + +SR E T+S S GDR + R
Sbjct: 812 FWTKDEDE--------TDGSEEVKETWHERLSRLESGGSNPTTSDSYGDRASARARREAR 863
Query: 824 YSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEK-ATQ 882
+ L +SR+E+D + D+KKLYE L EN+KLK +L + +EL D+K +LEK A Q
Sbjct: 864 EARL---ATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQ 920
Query: 883 RQERFADR-SLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKL 941
+QE+ +DR S+LEMEKRERRALER++SEMEEE+K+L +LK+DNQRLKDENGALIRVISKL
Sbjct: 921 KQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELKSDNQRLKDENGALIRVISKL 980
Query: 942 SK 943
SK
Sbjct: 981 SK 982
Score = 59.3 bits (142), Expect = 2e-08
Identities = 43/173 (24%), Positives = 82/173 (47%), Gaps = 17/173 (9%)
Query: 69 QNEVNRQGVDIEA-ARKEEERIMLRDARQWL---NSGHINDVRHAKSGG----------- 113
Q R+G + R+ R+ D +L +SG ++VR + G
Sbjct: 33 QEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGL 92
Query: 114 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 173
TALH A +++K L++ +VN +D +GWTPLHAAA G +++ + +
Sbjct: 93 TALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGI 152
Query: 174 VNKVGQTAFDVADEDILG--YLEELQKKQNLLHSEKRDKKSPLIESTANMDNN 224
VN G+ D+A+E + LE+++K+ L +++++ +++ N+
Sbjct: 153 VNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNS 205
>gi|14195601 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform b [Homo sapiens]
Length = 998
Score = 729 bits (1883), Expect = 0.0
Identities = 449/968 (46%), Positives = 602/968 (62%), Gaps = 110/968 (11%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MVKFLVEN AN+NQ DNEGW PLHAAASCGYL+IAE+ I GA VG VNSEG+ P D+AE
Sbjct: 106 MVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAE 165
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
E AM++LL +V +QG+D+E +RKEEE+ ML+DARQWLNSG I DVR A+SG TALHVAA
Sbjct: 166 EPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAA 225
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
AKGY+EVL+LLIQAGY++N++DYDGWTPLHAAAHWG +EAC IL + LCDM++ NK+GQT
Sbjct: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
Query: 181 AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP 240
FDVADE ++ +LE LQKKQN+L SEK + ++ LIES ++++ FKNKE ++ E
Sbjct: 286 PFDVADEGLVEHLELLQKKQNVLRSEK-ETRNKLIES--DLNSKIQSGFFKNKEKMLYEE 342
Query: 241 EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDK---TKPLASVTNAN 297
E K E EE K+ SS SSEE+E +D SE+ET+K KP A V ++N
Sbjct: 343 ----------ETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSN 392
Query: 298 TSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTG 357
+ S + + P ++ A S ++F ++ + K EE KDESP++WRLGLRKTG
Sbjct: 393 SESKSSITEQIPAPAQNTFSA---SSARRF---SSGLFNKPEEPKDESPSSWRLGLRKTG 446
Query: 358 SYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRR 417
S+ L+E+ S+E +++ ++ + RS+SSPR+S+ LDNK+KE+++K +Y++ PR+
Sbjct: 447 SHNMLSEVANSREPIRDRGSS-IYRSSSSPRISALLDNKDKERENK----SYISSLAPRK 501
Query: 418 LASTSDIEEKENRDSS-SLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLI 476
L STSDIEEKENR+S+ +L S SYTR+ W D+ K N
Sbjct: 502 LNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGN----------------------- 538
Query: 477 SSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEK 536
+P T + T ST K T S A T AE + +
Sbjct: 539 --EIPQTIAPSTY-------------VSTYLKRTPHKSQADTT--------AEKTADNVS 575
Query: 537 DSVPTAV-TIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQR 595
S P V T P+ N +T L+ T GT S+ E RE+RRSYLTPVRDEE+ES R
Sbjct: 576 SSTPLCVITNRPLPSTANGVTATPVLSIT--GT-DSSVEAREKRRSYLTPVRDEEAESLR 632
Query: 596 KARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEE 655
KARSRQARQ+RRSTQGVTLTDLQEAE+T RSR+ R +++ EK + + + ++ E
Sbjct: 633 KARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLEGSPEKHE 692
Query: 656 KKESETSREDEYKQKYSRTYDETYQRYR---PVSTSSSTTPSSSLSTMSSSLYASSQL-- 710
+ E +Q + R+ DE +R P TTP+S ST SLY SS L
Sbjct: 693 PSAVPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASP-STSRPSLYTSSHLLW 751
Query: 711 -NRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVS 769
NR + +S + T E + + EE E S+ SIRERRRP+E+RR TG++
Sbjct: 752 TNRFSVPDSESSETTTNTTTAKEMDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGIN 811
Query: 770 FWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYE------TSSTSAGDRYDSLLGRSGS 823
FWT+D DE T+ KET + +SR E T+S S GDR + R
Sbjct: 812 FWTKDEDE--------TDGSEEVKETWHERLSRLESGGSNPTTSDSYGDRASARARREAR 863
Query: 824 YSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEK-ATQ 882
+ L +SR+E+D + D+KKLYE L EN+KLK +L + +EL D+K +LEK A Q
Sbjct: 864 EARL---ATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQ 920
Query: 883 RQERFADR-SLLEMEKRERRALERRISEMEEE------LKMLPDLKADNQRLKDENGALI 935
+QE+ +DR S+LEMEKRERRALER++SEMEEE LK + LK N++L+ EN AL
Sbjct: 921 KQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKNLHQLKQIQTLKQMNEQLQAENRALT 980
Query: 936 RVISKLSK 943
RV+++LS+
Sbjct: 981 RVVARLSE 988
Score = 59.3 bits (142), Expect = 2e-08
Identities = 43/173 (24%), Positives = 82/173 (47%), Gaps = 17/173 (9%)
Query: 69 QNEVNRQGVDIEA-ARKEEERIMLRDARQWL---NSGHINDVRHAKSGG----------- 113
Q R+G + R+ R+ D +L +SG ++VR + G
Sbjct: 33 QEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGL 92
Query: 114 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 173
TALH A +++K L++ +VN +D +GWTPLHAAA G +++ + +
Sbjct: 93 TALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGI 152
Query: 174 VNKVGQTAFDVADEDILG--YLEELQKKQNLLHSEKRDKKSPLIESTANMDNN 224
VN G+ D+A+E + LE+++K+ L +++++ +++ N+
Sbjct: 153 VNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNS 205
>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
sapiens]
Length = 782
Score = 295 bits (756), Expect = 1e-79
Identities = 226/722 (31%), Positives = 336/722 (46%), Gaps = 89/722 (12%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+V+FLVE GA +NQ DNEGW PLH AASCGYLDIA +L+ GA++ AVNS+GD PLD+AE
Sbjct: 116 VVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAE 175
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
+AME LL+ E+ R+GVD+EAA++ EE ++L D R WLN G + + RH ++G +ALHVAA
Sbjct: 176 SDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAA 235
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
AKGY EV++LL+QAGYD ++D DGWTPLHAAAHWG E+ACR+L ++ M+ + GQ
Sbjct: 236 AKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQR 295
Query: 181 AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP 240
D+ADE++L LEEL +KQ L ++K S + Q+ + K++ +
Sbjct: 296 PCDLADEEVLSLLEELARKQEDLRNQKE-------ASQSRGQEPQAPSSSKHRRS----- 343
Query: 241 EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSS 300
+ R+ S +EK+ ++ K+ + +D+ E E + P
Sbjct: 344 --SVCRLSS--REKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPP----------- 388
Query: 301 TQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG 360
P +G ++P P SPK + +E+P + R GL KTGS G
Sbjct: 389 --------AEPRTLNGVSSPPHP-----------SPKSPVQLEEAPFSRRFGLLKTGSSG 429
Query: 361 ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLAS 420
AL G E+ TA A R +SS + +K RLA + PT +L
Sbjct: 430 AL--------GPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPE 481
Query: 421 TSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSV 480
S + E + L SS +R E + +V ST + S RR+ +
Sbjct: 482 PSVLSE-VTKPPPCLENSSPPSRIP-EPESPAKPNVPTASTAPPADSRDRRRSYQMPVRD 539
Query: 481 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEK---- 536
+ S S Q + T T + +AG + + D + + +
Sbjct: 540 EESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGV 599
Query: 537 ---DSVPTAVTIP----VAPTVV----------NAAASTTTLTTTTAGTVSSTTE----- 574
DS P P A SST E
Sbjct: 600 ENSDSPAQRAEAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSA 659
Query: 575 VRERRRSYLTPVRDEESESQ----RKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRST 630
R+R + L P + ESE R + R++ R + +T T L+ A+ + R+T
Sbjct: 660 RRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERAT 719
Query: 631 RTREQENEEK---EKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVST 687
+ +E+ E E E E++ E++ + E E + + R DE R +S
Sbjct: 720 QRQERFAERPALLELERFERRALERKAAELEEELKALSDLRADNQRLKDENAALIRVISK 779
Query: 688 SS 689
S
Sbjct: 780 LS 781
Score = 132 bits (333), Expect = 1e-30
Identities = 100/278 (35%), Positives = 146/278 (52%), Gaps = 29/278 (10%)
Query: 685 VSTSSSTTPSSSLSTMSSSLY------ASSQLNRPNSLVGITSAYSRGITKENEREGEKR 738
V T+S+ P+ S S + SQ + L+ + ++G+T + +E EK
Sbjct: 515 VPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKA 574
Query: 739 EEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTD 798
K E + +S+ RRPR GV ++SD Q ++ +G + +
Sbjct: 575 AG-KAPESEKPAQSLDPSRRPRVP----GV----ENSDSPAQRAEAPDGQGPGPQAAREH 625
Query: 799 SISRYETSSTSAGDRYDSLLGRSGSYSYLE------------ERKPYSSRLEKDDSTDFK 846
E + G+ + RS S LE + P ++ F+
Sbjct: 626 RKVGKEWRGPAEGEEAEPA-DRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFR 684
Query: 847 KLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADR-SLLEMEKRERRALER 905
LY ++ ENE+L+ L +T + L LK++LE+ATQRQERFA+R +LLE+E+ ERRALER
Sbjct: 685 TLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALER 744
Query: 906 RISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK 943
+ +E+EEELK L DL+ADNQRLKDEN ALIRVISKLSK
Sbjct: 745 KAAELEEELKALSDLRADNQRLKDENAALIRVISKLSK 782
Score = 93.6 bits (231), Expect = 8e-19
Identities = 94/318 (29%), Positives = 125/318 (39%), Gaps = 40/318 (12%)
Query: 481 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP 540
P T AGLQ+S SS T + T + E S E P
Sbjct: 433 PPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPP 492
Query: 541 TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR 600
+ P+ + S TA T + + R+RRRSY PVRDEESESQRKARSR
Sbjct: 493 PCLENSSPPSRIPEPESPAKPNVPTAST-APPADSRDRRRSYQMPVRDEESESQRKARSR 551
Query: 601 QARQSRRSTQGVTLTDLQEAEKTIGR-------------SRSTRTREQENEEKEKEEKEK 647
RQSRRSTQGVTLTDL+EAEK G+ SR R EN + + E
Sbjct: 552 LMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEA 611
Query: 648 QD---------KEKQEEKKESETSREDEYKQKYSRTYD------------ETYQR-YRPV 685
D +E ++ KE E E + R+ + + +QR P
Sbjct: 612 PDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPE 671
Query: 686 STSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGE 745
S P T LYA + +T R + E E + +E+ E
Sbjct: 672 PEPESEEPDGGFRT----LYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAE 727
Query: 746 DKSQPKSIRERRRPREKR 763
+ + R RR E++
Sbjct: 728 RPALLELERFERRALERK 745
Score = 58.5 bits (140), Expect = 3e-08
Identities = 36/109 (33%), Positives = 59/109 (54%), Gaps = 2/109 (1%)
Query: 112 GGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDM 171
G +ALH A EV++ L++ G VN D +GWTPLH AA G + R L+ + ++
Sbjct: 101 GISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANI 160
Query: 172 EMVNKVGQTAFDVADEDIL-GYLE-ELQKKQNLLHSEKRDKKSPLIEST 218
VN G D+A+ D + G L+ E+ ++ + + KR ++ L+ T
Sbjct: 161 AAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDT 209
>gi|14195597 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform c [Homo sapiens]
Length = 208
Score = 194 bits (492), Expect = 4e-49
Identities = 113/215 (52%), Positives = 147/215 (68%), Gaps = 19/215 (8%)
Query: 737 KREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQ 796
+ EE E S+ SIRERRRP+E+RR TG++FWT+D DE T+ KET
Sbjct: 5 ENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDE--------TDGSEEVKETW 56
Query: 797 TDSISRYE------TSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYE 850
+ +SR E T+S S GDR + R + L +SR+E+D + D+KKLYE
Sbjct: 57 HERLSRLESGGSNPTTSDSYGDRASARARREAREARL---ATLTSRVEEDSNRDYKKLYE 113
Query: 851 QILAENEKLKAQLHDTNMELTDLKLQLEK-ATQRQERFADR-SLLEMEKRERRALERRIS 908
L EN+KLK +L + +EL D+K +LEK A Q+QE+ +DR S+LEMEKRERRALER++S
Sbjct: 114 SALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMS 173
Query: 909 EMEEELKMLPDLKADNQRLKDENGALIRVISKLSK 943
EMEEE+K+L +LK+DNQRLKDENGALIRVISKLSK
Sbjct: 174 EMEEEMKVLTELKSDNQRLKDENGALIRVISKLSK 208
>gi|14195599 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform d [Homo sapiens]
Length = 224
Score = 165 bits (417), Expect = 2e-40
Identities = 102/221 (46%), Positives = 140/221 (63%), Gaps = 25/221 (11%)
Query: 737 KREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQ 796
+ EE E S+ SIRERRRP+E+RR TG++FWT+D DE T+ KET
Sbjct: 5 ENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDE--------TDGSEEVKETW 56
Query: 797 TDSISRYE------TSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYE 850
+ +SR E T+S S GDR + R + L +SR+E+D + D+KKLYE
Sbjct: 57 HERLSRLESGGSNPTTSDSYGDRASARARREAREARL---ATLTSRVEEDSNRDYKKLYE 113
Query: 851 QILAENEKLKAQLHDTNMELTDLKLQLEK-ATQRQERFADR-SLLEMEKRERRALERRIS 908
L EN+KLK +L + +EL D+K +LEK A Q+QE+ +DR S+LEMEKRERRALER++S
Sbjct: 114 SALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMS 173
Query: 909 EMEEE------LKMLPDLKADNQRLKDENGALIRVISKLSK 943
EMEEE LK + LK N++L+ EN AL RV+++LS+
Sbjct: 174 EMEEEMKNLHQLKQIQTLKQMNEQLQAENRALTRVVARLSE 214
>gi|14249672 protein phosphatase 1, regulatory (inhibitor) subunit
16A [Homo sapiens]
Length = 528
Score = 150 bits (379), Expect = 5e-36
Identities = 121/372 (32%), Positives = 182/372 (48%), Gaps = 23/372 (6%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MV+ L+E GANIN D+E W PLHAAA+CG+L + E LI GA++ AVN++G+ P D+ +
Sbjct: 119 MVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCD 178
Query: 61 EEAMEELLQNEVNRQGV---DIEAARKEEERIMLRDARQWLNSGHINDVRHA--KSGGTA 115
+E + L+ + +G+ IEAAR E ML D R L +G D+ HA G T
Sbjct: 179 DEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAG--ADL-HAPLDHGATL 235
Query: 116 LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVN 175
LHVAAA G++E LL++ ++ KD DGW PLHAAA+WG+ +LV + D+ +
Sbjct: 236 LHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKS 295
Query: 176 KVGQTAFDV-ADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQS--QKTFKN 232
+ +T DV DE++ L EL+ K + L + ++S L T++ + ++
Sbjct: 296 LMDETPLDVCGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLT 355
Query: 233 KETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSE----EDEEDDSE------SEA 282
+ T + + I + E D+ +E EED+ E
Sbjct: 356 QRTDLYRKQHAQEAIVWQQPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRV 415
Query: 283 ETDKTKPLASVTNANTSSTQAAPVAVTTP-TVSSGQATPTSPIKKFPTTATKISPKEEER 341
+ L S + S Q +P+ TTP T+ +A T K A K+ E
Sbjct: 416 GGSPVRHLYSKRLDRSVSYQLSPLDSTTPHTLVHDKAHHTLADLKRQRAAAKLQRPPPE- 474
Query: 342 KDESPATWRLGL 353
ESP T GL
Sbjct: 475 GPESPETAEPGL 486
Score = 62.4 bits (150), Expect = 2e-09
Identities = 36/110 (32%), Positives = 62/110 (56%), Gaps = 5/110 (4%)
Query: 79 IEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDV 138
+EAA + + L + RQ+L SG D+ + + G TALH + E+++ L++AG ++
Sbjct: 76 LEAAARND----LEEVRQFLGSGVSPDLAN-EDGLTALHQCCIDDFREMVQQLLEAGANI 130
Query: 139 NIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADED 188
N D + WTPLHAAA G +L+ + ++ VN G +D+ D++
Sbjct: 131 NACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDE 180
>gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 16B
[Homo sapiens]
Length = 567
Score = 142 bits (357), Expect = 2e-33
Identities = 78/224 (34%), Positives = 128/224 (57%), Gaps = 5/224 (2%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+VK L+ +GAN+N DNE W PLHAAA+CG++++ + L+ GA + AVNS+G+ P D+ E
Sbjct: 116 IVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCE 175
Query: 61 EEAMEELLQNEVNRQGV---DIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALH 117
+E ++++ + QG+ I R E+ M+ D + +G D A+ G T LH
Sbjct: 176 DEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQ-GATLLH 234
Query: 118 VAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKV 177
+A A GY +LL+ G V++KD+DGW PLHAAA WG+ + +LV + + +
Sbjct: 235 IAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSM 294
Query: 178 GQTAFDVA-DEDILGYLEELQKKQNLLHSEKRDKKSPLIESTAN 220
+ D+ +E+ L EL+ K +++ + KS L T++
Sbjct: 295 DEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSS 338
Score = 62.0 bits (149), Expect = 3e-09
Identities = 36/94 (38%), Positives = 49/94 (52%), Gaps = 1/94 (1%)
Query: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
+ G TALH + E++KLL+ G +VN KD + WTPLHAAA G +ILV
Sbjct: 99 EDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGA 158
Query: 170 DMEMVNKVGQTAFDVA-DEDILGYLEELQKKQNL 202
D+ VN G +D+ DE L +E Q +
Sbjct: 159 DLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGI 192
>gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]
Length = 1858
Score = 117 bits (294), Expect = 4e-26
Identities = 74/223 (33%), Positives = 120/223 (53%), Gaps = 12/223 (5%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ + L++ G N+N D + W P+H A +C DI L+ GA+V + G+ PLD A
Sbjct: 108 IAEILIDRGVNVNHQDEDFWTPMHIACACDNPDIVLLLVLAGANVLLQDVNGNIPLDYAV 167
Query: 61 EEA-MEELLQNEVNRQGVDIEAARK---EEERIMLRDARQWLNSG-HINDVRHAKSGGTA 115
E +L ++ GVD+ + R+ + ML D + +L+SG ++N+ G T
Sbjct: 168 EGTESSSILLTYLDENGVDLTSLRQMKLQRPMSMLTDVKHFLSSGGNVNEKND--EGVTL 225
Query: 116 LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVN 175
LH+A A GY EV+ L+++ G D+NI D WTPLH AA +G+ ++L+ + + +VN
Sbjct: 226 LHMACASGYKEVVSLILEHGGDLNIVDDQYWTPLHLAAKYGQTNLVKLLLMHQANPHLVN 285
Query: 176 KVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIEST 218
+ A D+A + ++EE+ K + EK K PL ST
Sbjct: 286 CNEEKASDIAASE---FIEEMLLKAEIAWEEK--MKEPLSAST 323
Score = 43.1 bits (100), Expect = 0.001
Identities = 33/130 (25%), Positives = 55/130 (42%), Gaps = 6/130 (4%)
Query: 111 SGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCD 170
SGG+ LH+ A + ++LI G +VN +D D WTP+H A + +LV +
Sbjct: 92 SGGSLLHLCARYDNAFIAEILIDRGVNVNHQDEDFWTPMHIACACDNPDIVLLLVLAGAN 151
Query: 171 MEMVNKVGQTAFDVADED------ILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNN 224
+ + + G D A E +L YL+E L K + ++ + ++
Sbjct: 152 VLLQDVNGNIPLDYAVEGTESSSILLTYLDENGVDLTSLRQMKLQRPMSMLTDVKHFLSS 211
Query: 225 QSQKTFKNKE 234
KN E
Sbjct: 212 GGNVNEKNDE 221
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 94.0 bits (232), Expect = 6e-19
Identities = 173/829 (20%), Positives = 319/829 (38%), Gaps = 103/829 (12%)
Query: 111 SGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCD 170
+G T LH A GY +V K+LI AG DVN + D TPLH +A G + ++L+ + +
Sbjct: 194 AGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGN 253
Query: 171 MEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKR---DKKSPLIESTANMDNNQSQ 227
NK G+ DVA+ + LE L K++ L + D + + +++D N
Sbjct: 254 PFQANKHGERPVDVAETE---ELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDS 310
Query: 228 KTFKNK---ETLIIEPEKN--ASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEA 282
+T K+ E+ I P K S ++ E + D+EE K + +++ ++E EA
Sbjct: 311 ETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEA 370
Query: 283 ETDKTKPLASVTNA----NTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKE 338
E KT A A + S + P V + S KK T+ + I
Sbjct: 371 E--KTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQN-KKISTSCSVI---- 423
Query: 339 EERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEK 398
P T ++ Y + + + QK K V R + + ++
Sbjct: 424 -------PETSNSDMQTKKEY-----VVSGEHKQKGK----VKRKLKNQNKNKENQELKQ 467
Query: 399 EKDSK-GTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVN 457
EK+ K TR+ + + + D EK R+ + R S S +D ++
Sbjct: 468 EKEGKENTRITNLT------VNTGLDCSEK-TREEGNFRKSFS----PKDDTSLHLFHIS 516
Query: 458 EGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSA- 516
G + SC +Q + T +P +S LQ L+ +T ++ SSS
Sbjct: 517 TGKSPKHSCGLSEKQSTPLKQEHTKTCLSPG-SSEMSLQPDLVRYDNTESEFLPESSSVK 575
Query: 517 -------GTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTV 569
+ + E S K KD +PT N + T G
Sbjct: 576 SCKHKEKSKHQKDFHLEFGEKSNAKIKDE-------DHSPTFEN--SDCTLKKMDKEGKT 626
Query: 570 SSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRS 629
+++ + R ++ E E ++ A++ +RS + D + ++ +S
Sbjct: 627 LKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVE----FDREFWKENFFKSDE 682
Query: 630 TRT--REQENEEKEKEEKEKQDKEKQEEK--KESETSREDEYKQKYSRTYDETYQRYRPV 685
T E+E E+K K +K +++K KE S+E +K++ + E+ + +R
Sbjct: 683 TEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREE 742
Query: 686 STSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGE 745
++ T S + S ++ +G+ EKE +
Sbjct: 743 KIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLV------------------EKEID 784
Query: 746 DKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYET 805
+ Q K I+E + EKR ++ D + E+++ +E K E +++ +
Sbjct: 785 IEKQEKHIKESKEKPEKRSQ------IKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLS 838
Query: 806 SSTSAGDRYDSLLGRSGSYSYLE-ERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLH 864
D L + E E+ ++ ++K D D +K E++ +++K K +
Sbjct: 839 ECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTD--DREKSREKMDRKHDKEKPEKE 896
Query: 865 DTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEE 913
E + L +K Q +S K + R L+++ ++E
Sbjct: 897 RHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKE 945
Score = 81.3 bits (199), Expect = 4e-15
Identities = 183/987 (18%), Positives = 375/987 (37%), Gaps = 126/987 (12%)
Query: 2 VKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEE 61
VK L+ GAN+N D GW PLH A + GY D+A+ LI GA V + DTPL +
Sbjct: 178 VKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSAS 237
Query: 62 EAMEELLQ------------NEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHA 109
++++ N+ + VD+ A +E E ++ R+ + D A
Sbjct: 238 SGHRDIVKLLLRHGGNPFQANKHGERPVDV-AETEELELLLKREVPLSDDDESYTDSEEA 296
Query: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAA--AHWGKEEACRILVDN 167
+S + TE L+ ++ + K TPL +A + K++ +
Sbjct: 297 QSVNPSSVDENIDSETEKDSLICESKQILPSK-----TPLPSALDEYEFKDDDDEEINKM 351
Query: 168 LCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQ 227
+ D ++ K + + E + ++ + K+ K S ++ S+ + ++
Sbjct: 352 IDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEAL 411
Query: 228 KTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGK-----KDESSCSSEEDEEDDSESEA 282
+ K + + PE + S +++ ++ V E + K K ++ ++E++E E E
Sbjct: 412 QNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEG 471
Query: 283 E----------------TDKTKP----LASVTNANTSSTQAAPVAV-TTPTVSSGQATPT 321
+ ++KT+ S + + +S ++ +P S G +
Sbjct: 472 KENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQ 531
Query: 322 SPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQK-------- 373
S K T T +SP E + P R ++ + + + K +K
Sbjct: 532 STPLKQEHTKTCLSPGSSEMSLQ-PDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFH 590
Query: 374 ----EKDTAGVTRSASSPRL-SSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIE-EK 427
EK A + SP +S K+ +K+ K + + + +IE EK
Sbjct: 591 LEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEK 650
Query: 428 E---NRDSS-SLRTSSSYTRRKWEDDLKKNSSVNE--GSTYHKSCSFGRRQDDLISSSVP 481
E +DS+ L+ S + R W+++ K+ + + H+S + ++ +
Sbjct: 651 EKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDD 710
Query: 482 STTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPT 541
+T V+ ++ KI S + + + ++ +KDS T
Sbjct: 711 KSTKEKHVSKERNFKEE-------RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFT 763
Query: 542 AVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQ 601
++ + + + ++ + +RS + E+ E + + ++
Sbjct: 764 SLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKK 823
Query: 602 ARQSRRSTQ-----GVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEK 656
+ +S + + ++E +K +E E + K+ D+EK EK
Sbjct: 824 IKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREK 883
Query: 657 KESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSL 716
+ + +E K+++ E + + S ++ S S
Sbjct: 884 MDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKS-------------------- 923
Query: 717 VGITSAYSRGITKENEREGEKREE--EKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQD 774
+G KE +RE +K+E+ +KE + + K I+E ++ +
Sbjct: 924 -------EKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLS 976
Query: 775 SDENEQEQQSDTEEGSNKKETQTDSISRY-ETSSTSAGDRYDSLLGRSGSYSYLEERKPY 833
E +++ T +G K + D I RY E + +SLL S ++ KP
Sbjct: 977 LKEKTKDEPLKTPDGKEKDKKDKD-IDRYKERDKHKDKIQINSLLKLK---SEADKPKPK 1032
Query: 834 SSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQ------LEKATQRQ-ER 886
SS KD K+L N+ L + + L DL+++ EK Q++ ER
Sbjct: 1033 SSPASKDTRPKEKRLV------NDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKER 1086
Query: 887 FADRSLLEMEKRERRALERRISEMEEE 913
+R+ LE++ +++ + +E + +
Sbjct: 1087 LRNRNCLELKIKDKEKTKHTPTESKNK 1113
Score = 45.4 bits (106), Expect = 2e-04
Identities = 161/855 (18%), Positives = 303/855 (35%), Gaps = 151/855 (17%)
Query: 213 PLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDE----SSC 268
P+ ++ D+N +K + K I +IE + K +E+ K + S
Sbjct: 9 PIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISP 68
Query: 269 SSEEDEEDDSESEA-ETDKTKPLASVTNANTSS----------TQAAPVAVTTPTVSSGQ 317
S E+ + D+E E E KTK A + S Q A + T +S
Sbjct: 69 SRNEERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPD 128
Query: 318 ATPTSPI------KKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEG 371
+TP P KK P+++++ K +R + + + G + E+ +
Sbjct: 129 STPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIR-GDVKQVKELISLGAN 187
Query: 372 QKEKDTAGVTR-----------------SASSPRLSSSLDNKEKEKDSKGTRLAYVAPTI 414
KD AG T +A + + LD+ DS + + +
Sbjct: 188 VNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLL 247
Query: 415 ----------------PRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNE 458
P +A T ++E R+ SYT D ++ SVN
Sbjct: 248 LRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYT------DSEEAQSVNP 301
Query: 459 GSTYHKSCSFGRRQDDLISSS---VPSTTSTPTVTSAAGLQ----KSLLSSTSTTTKITT 511
S+ ++ +D LI S +PS T P+ + + + +
Sbjct: 302 -SSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRK 360
Query: 512 GSSSAGTQSSTSNRLWAED------STEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTT 565
+ L+A+ + K K P+ V + A ++T+
Sbjct: 361 EQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSC 420
Query: 566 AGTVSSTTEVRERRRSYLTPVRDEES-----ESQRKARSRQARQSRRSTQGVTLTDLQEA 620
+ ++ + ++ Y+ ++ + + + ++++ ++ ++ +G T +
Sbjct: 421 SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNL 480
Query: 621 EKTIGRSRSTRTREQENEEKEKEEK-----------------------EKQDKE-KQEEK 656
G S +TRE+ N K K EKQ KQE
Sbjct: 481 TVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHT 540
Query: 657 KESETSREDEYK-QKYSRTYDETYQRYRPVSTSSSTTPSSSLST----------MSSSLY 705
K + E Q YD T + P S+S + S S+
Sbjct: 541 KTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAK 600
Query: 706 ASSQLNRP---NSLVGITSAYSRGIT------KENEREGEKREEEKEGE-DKSQPK-SIR 754
+ + P NS + G T K ERE EK ++E EGE +K + K S +
Sbjct: 601 IKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAK 660
Query: 755 ERRRPREKRRSTGVSFWTQD---SDENE-----QEQQSDTEEGSNK--------KETQTD 798
E +R E R FW ++ SDE E E +S T E +K K T+
Sbjct: 661 ELQRSVEFDR----EFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEK 716
Query: 799 SISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEK 858
+S+ E + D+ +S +++ K + D ++F L + A E
Sbjct: 717 HVSK-ERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSL--GMSAIEES 773
Query: 859 LKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRAL--ERRISEMEEELKM 916
+ L + +++ + ++++ ++ E+ + ++EK ER+ E++I + K
Sbjct: 774 IGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKD 833
Query: 917 LPDLKADNQRLKDEN 931
DL ++K+++
Sbjct: 834 KLDLSECVDKIKEKD 848
Score = 40.4 bits (93), Expect = 0.008
Identities = 110/572 (19%), Positives = 216/572 (37%), Gaps = 91/572 (15%)
Query: 188 DILGYLEELQKKQNLL--HSEKRDKKSPLIESTANM---DNNQSQKTFKNKETLIIEPEK 242
D+ ++++++K L H+EK K+ ++TA + D+ + + +++ +PEK
Sbjct: 836 DLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEK 895
Query: 243 NASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKT-----KPLASVTNA- 296
ES E+ + E++ K+ ++S S+ ++ + E + E DK K ++TN+
Sbjct: 896 ERHLAESKEKHLM--EKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 953
Query: 297 -----NTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRL 351
SS A +S + T P+K KE+++KD+
Sbjct: 954 HIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLK-------TPDGKEKDKKDK------- 999
Query: 352 GLRKTGSYGALAEITASKEGQKEKDTAGVT------RSASSPRLSSSLDNKEKEKDSKGT 405
+I KE K KD + A P+ SS +K+ K
Sbjct: 1000 ------------DIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRL 1047
Query: 406 RLAYVAPTIPRRLASTSDIE---------------EKE---NRDSSSLR-TSSSYTRRKW 446
+ T R+ S D+E EKE NR+ L+ T+
Sbjct: 1048 VNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTP 1107
Query: 447 EDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTT 506
+ K + ++ S + + ++ D +S+ S + +T + S +S S
Sbjct: 1108 TESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLG---KSSFVSDNSLN 1164
Query: 507 TKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTA 566
+ + G S + + + S +DS T VT P P + S L ++ +
Sbjct: 1165 RSPRSENEKPGLSSRSVSMI----SVASSEDSCHTTVTTPRPPVEYD---SDFMLESSES 1217
Query: 567 GTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGR 626
S + +S R+ +S + R + +R ST + + +++ + I
Sbjct: 1218 QMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISE 1277
Query: 627 SRSTRTREQENEEKEKEEKEKQDKEKQEEKKE-------SETSREDEYKQKYSRTYDETY 679
R T + + E KQ + EE + +TS + + +S +
Sbjct: 1278 GRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPK-PEVFSNVPERDL 1336
Query: 680 QRYRPVSTSSSTTPSSSLSTMSSSLYASSQLN 711
+ +S +T+P+ + S+S Y S+ N
Sbjct: 1337 SNVSNIHSSFATSPTGA----SNSKYVSADRN 1364
Score = 37.4 bits (85), Expect = 0.066
Identities = 100/554 (18%), Positives = 194/554 (35%), Gaps = 105/554 (18%)
Query: 220 NMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSE 279
NM++ K+K I+ +K+ ++ EE + K ES S E++ D +
Sbjct: 689 NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLK 748
Query: 280 SEAETDKTKPLASVTNANTSSTQAA----------PVAVTTPTVSSGQATPT--SPIKKF 327
E E T + T+ S+ + + + + + P S IK+
Sbjct: 749 EERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEK 808
Query: 328 PTTATKISPKEEERK---DESPATWRLGL--------RKTGSYGALAEITASKEGQKEKD 376
+ E+E+K + +L L K Y E KEG+K K+
Sbjct: 809 DIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTE-KCHKEGEKSKN 867
Query: 377 TAGVTRSASSPRLSSSLDNK-EKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSL 435
TA + ++ + +D K +KEK K LA + + EK+N+ S +
Sbjct: 868 TAAIKKTDDREKSREKMDRKHDKEKPEKERHLAE---------SKEKHLMEKKNKQSDNS 918
Query: 436 RTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGL 495
S S +G K +++ S+ +T++ +
Sbjct: 919 EYSKS----------------EKGKNKEKDRELDKKEKSRDKESI-------NITNSKHI 955
Query: 496 QKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAA 555
Q+ SS K + + + L D EK+K
Sbjct: 956 QEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKD----------------- 998
Query: 556 ASTTTLTTTTAGTVSSTTEVRERRR-------SYLTPVRDEESESQRKARSRQARQSRRS 608
+ER + + L ++ E + + K+ S ++ +R
Sbjct: 999 --------------KDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKS-SPASKDTRPK 1043
Query: 609 TQGVTLTDLQEAEKTIGRSRSTRTREQEN-EEKEKEEKEKQDKEKQEEKKESETSREDEY 667
+ + DL + + R S + E E +K KE+ ++++KE+ + E +D+
Sbjct: 1044 EKRLVNDDLMQT--SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKE 1101
Query: 668 KQKYSRTYDETYQRYRPVST------SSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITS 721
K K++ T + + R S+ + P ++S S S+ + + S +
Sbjct: 1102 KTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDN 1161
Query: 722 AYSRGITKENEREG 735
+ +R ENE+ G
Sbjct: 1162 SLNRSPRSENEKPG 1175
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 94.0 bits (232), Expect = 6e-19
Identities = 173/829 (20%), Positives = 319/829 (38%), Gaps = 103/829 (12%)
Query: 111 SGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCD 170
+G T LH A GY +V K+LI AG DVN + D TPLH +A G + ++L+ + +
Sbjct: 217 AGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGN 276
Query: 171 MEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKR---DKKSPLIESTANMDNNQSQ 227
NK G+ DVA+ + LE L K++ L + D + + +++D N
Sbjct: 277 PFQANKHGERPVDVAETE---ELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDS 333
Query: 228 KTFKNK---ETLIIEPEKN--ASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEA 282
+T K+ E+ I P K S ++ E + D+EE K + +++ ++E EA
Sbjct: 334 ETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEA 393
Query: 283 ETDKTKPLASVTNA----NTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKE 338
E KT A A + S + P V + S KK T+ + I
Sbjct: 394 E--KTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQN-KKISTSCSVI---- 446
Query: 339 EERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEK 398
P T ++ Y + + + QK K V R + + ++
Sbjct: 447 -------PETSNSDMQTKKEY-----VVSGEHKQKGK----VKRKLKNQNKNKENQELKQ 490
Query: 399 EKDSK-GTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVN 457
EK+ K TR+ + + + D EK R+ + R S S +D ++
Sbjct: 491 EKEGKENTRITNLT------VNTGLDCSEK-TREEGNFRKSFS----PKDDTSLHLFHIS 539
Query: 458 EGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSA- 516
G + SC +Q + T +P +S LQ L+ +T ++ SSS
Sbjct: 540 TGKSPKHSCGLSEKQSTPLKQEHTKTCLSPG-SSEMSLQPDLVRYDNTESEFLPESSSVK 598
Query: 517 -------GTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTV 569
+ + E S K KD +PT N + T G
Sbjct: 599 SCKHKEKSKHQKDFHLEFGEKSNAKIKDE-------DHSPTFEN--SDCTLKKMDKEGKT 649
Query: 570 SSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRS 629
+++ + R ++ E E ++ A++ +RS + D + ++ +S
Sbjct: 650 LKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVE----FDREFWKENFFKSDE 705
Query: 630 TRT--REQENEEKEKEEKEKQDKEKQEEK--KESETSREDEYKQKYSRTYDETYQRYRPV 685
T E+E E+K K +K +++K KE S+E +K++ + E+ + +R
Sbjct: 706 TEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREE 765
Query: 686 STSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGE 745
++ T S + S ++ +G+ EKE +
Sbjct: 766 KIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLV------------------EKEID 807
Query: 746 DKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYET 805
+ Q K I+E + EKR ++ D + E+++ +E K E +++ +
Sbjct: 808 IEKQEKHIKESKEKPEKRSQ------IKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLS 861
Query: 806 SSTSAGDRYDSLLGRSGSYSYLE-ERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLH 864
D L + E E+ ++ ++K D D +K E++ +++K K +
Sbjct: 862 ECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTD--DREKSREKMDRKHDKEKPEKE 919
Query: 865 DTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEE 913
E + L +K Q +S K + R L+++ ++E
Sbjct: 920 RHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKE 968
Score = 81.3 bits (199), Expect = 4e-15
Identities = 183/987 (18%), Positives = 375/987 (37%), Gaps = 126/987 (12%)
Query: 2 VKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEE 61
VK L+ GAN+N D GW PLH A + GY D+A+ LI GA V + DTPL +
Sbjct: 201 VKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSAS 260
Query: 62 EAMEELLQ------------NEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHA 109
++++ N+ + VD+ A +E E ++ R+ + D A
Sbjct: 261 SGHRDIVKLLLRHGGNPFQANKHGERPVDV-AETEELELLLKREVPLSDDDESYTDSEEA 319
Query: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAA--AHWGKEEACRILVDN 167
+S + TE L+ ++ + K TPL +A + K++ +
Sbjct: 320 QSVNPSSVDENIDSETEKDSLICESKQILPSK-----TPLPSALDEYEFKDDDDEEINKM 374
Query: 168 LCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQ 227
+ D ++ K + + E + ++ + K+ K S ++ S+ + ++
Sbjct: 375 IDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEAL 434
Query: 228 KTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGK-----KDESSCSSEEDEEDDSESEA 282
+ K + + PE + S +++ ++ V E + K K ++ ++E++E E E
Sbjct: 435 QNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEG 494
Query: 283 E----------------TDKTKP----LASVTNANTSSTQAAPVAV-TTPTVSSGQATPT 321
+ ++KT+ S + + +S ++ +P S G +
Sbjct: 495 KENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQ 554
Query: 322 SPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQK-------- 373
S K T T +SP E + P R ++ + + + K +K
Sbjct: 555 STPLKQEHTKTCLSPGSSEMSLQ-PDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFH 613
Query: 374 ----EKDTAGVTRSASSPRL-SSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIE-EK 427
EK A + SP +S K+ +K+ K + + + +IE EK
Sbjct: 614 LEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEK 673
Query: 428 E---NRDSS-SLRTSSSYTRRKWEDDLKKNSSVNE--GSTYHKSCSFGRRQDDLISSSVP 481
E +DS+ L+ S + R W+++ K+ + + H+S + ++ +
Sbjct: 674 EKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDD 733
Query: 482 STTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPT 541
+T V+ ++ KI S + + + ++ +KDS T
Sbjct: 734 KSTKEKHVSKERNFKEE-------RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFT 786
Query: 542 AVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQ 601
++ + + + ++ + +RS + E+ E + + ++
Sbjct: 787 SLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKK 846
Query: 602 ARQSRRSTQ-----GVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEK 656
+ +S + + ++E +K +E E + K+ D+EK EK
Sbjct: 847 IKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREK 906
Query: 657 KESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSL 716
+ + +E K+++ E + + S ++ S S
Sbjct: 907 MDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKS-------------------- 946
Query: 717 VGITSAYSRGITKENEREGEKREE--EKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQD 774
+G KE +RE +K+E+ +KE + + K I+E ++ +
Sbjct: 947 -------EKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLS 999
Query: 775 SDENEQEQQSDTEEGSNKKETQTDSISRY-ETSSTSAGDRYDSLLGRSGSYSYLEERKPY 833
E +++ T +G K + D I RY E + +SLL S ++ KP
Sbjct: 1000 LKEKTKDEPLKTPDGKEKDKKDKD-IDRYKERDKHKDKIQINSLLKLK---SEADKPKPK 1055
Query: 834 SSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQ------LEKATQRQ-ER 886
SS KD K+L N+ L + + L DL+++ EK Q++ ER
Sbjct: 1056 SSPASKDTRPKEKRLV------NDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKER 1109
Query: 887 FADRSLLEMEKRERRALERRISEMEEE 913
+R+ LE++ +++ + +E + +
Sbjct: 1110 LRNRNCLELKIKDKEKTKHTPTESKNK 1136
Score = 40.4 bits (93), Expect = 0.008
Identities = 110/572 (19%), Positives = 216/572 (37%), Gaps = 91/572 (15%)
Query: 188 DILGYLEELQKKQNLL--HSEKRDKKSPLIESTANM---DNNQSQKTFKNKETLIIEPEK 242
D+ ++++++K L H+EK K+ ++TA + D+ + + +++ +PEK
Sbjct: 859 DLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEK 918
Query: 243 NASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKT-----KPLASVTNA- 296
ES E+ + E++ K+ ++S S+ ++ + E + E DK K ++TN+
Sbjct: 919 ERHLAESKEKHLM--EKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 976
Query: 297 -----NTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRL 351
SS A +S + T P+K KE+++KD+
Sbjct: 977 HIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLK-------TPDGKEKDKKDK------- 1022
Query: 352 GLRKTGSYGALAEITASKEGQKEKDTAGVT------RSASSPRLSSSLDNKEKEKDSKGT 405
+I KE K KD + A P+ SS +K+ K
Sbjct: 1023 ------------DIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRL 1070
Query: 406 RLAYVAPTIPRRLASTSDIE---------------EKE---NRDSSSLR-TSSSYTRRKW 446
+ T R+ S D+E EKE NR+ L+ T+
Sbjct: 1071 VNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTP 1130
Query: 447 EDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTT 506
+ K + ++ S + + ++ D +S+ S + +T + S +S S
Sbjct: 1131 TESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLG---KSSFVSDNSLN 1187
Query: 507 TKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTA 566
+ + G S + + + S +DS T VT P P + S L ++ +
Sbjct: 1188 RSPRSENEKPGLSSRSVSMI----SVASSEDSCHTTVTTPRPPVEYD---SDFMLESSES 1240
Query: 567 GTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGR 626
S + +S R+ +S + R + +R ST + + +++ + I
Sbjct: 1241 QMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISE 1300
Query: 627 SRSTRTREQENEEKEKEEKEKQDKEKQEEKKE-------SETSREDEYKQKYSRTYDETY 679
R T + + E KQ + EE + +TS + + +S +
Sbjct: 1301 GRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPK-PEVFSNVPERDL 1359
Query: 680 QRYRPVSTSSSTTPSSSLSTMSSSLYASSQLN 711
+ +S +T+P+ + S+S Y S+ N
Sbjct: 1360 SNVSNIHSSFATSPTGA----SNSKYVSADRN 1387
Score = 37.4 bits (85), Expect = 0.066
Identities = 100/554 (18%), Positives = 194/554 (35%), Gaps = 105/554 (18%)
Query: 220 NMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSE 279
NM++ K+K I+ +K+ ++ EE + K ES S E++ D +
Sbjct: 712 NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLK 771
Query: 280 SEAETDKTKPLASVTNANTSSTQAA----------PVAVTTPTVSSGQATPT--SPIKKF 327
E E T + T+ S+ + + + + + P S IK+
Sbjct: 772 EERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEK 831
Query: 328 PTTATKISPKEEERK---DESPATWRLGL--------RKTGSYGALAEITASKEGQKEKD 376
+ E+E+K + +L L K Y E KEG+K K+
Sbjct: 832 DIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTE-KCHKEGEKSKN 890
Query: 377 TAGVTRSASSPRLSSSLDNK-EKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSL 435
TA + ++ + +D K +KEK K LA + + EK+N+ S +
Sbjct: 891 TAAIKKTDDREKSREKMDRKHDKEKPEKERHLAE---------SKEKHLMEKKNKQSDNS 941
Query: 436 RTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGL 495
S S +G K +++ S+ +T++ +
Sbjct: 942 EYSKS----------------EKGKNKEKDRELDKKEKSRDKESI-------NITNSKHI 978
Query: 496 QKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAA 555
Q+ SS K + + + L D EK+K
Sbjct: 979 QEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKD----------------- 1021
Query: 556 ASTTTLTTTTAGTVSSTTEVRERRR-------SYLTPVRDEESESQRKARSRQARQSRRS 608
+ER + + L ++ E + + K+ S ++ +R
Sbjct: 1022 --------------KDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKS-SPASKDTRPK 1066
Query: 609 TQGVTLTDLQEAEKTIGRSRSTRTREQEN-EEKEKEEKEKQDKEKQEEKKESETSREDEY 667
+ + DL + + R S + E E +K KE+ ++++KE+ + E +D+
Sbjct: 1067 EKRLVNDDLMQT--SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKE 1124
Query: 668 KQKYSRTYDETYQRYRPVST------SSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITS 721
K K++ T + + R S+ + P ++S S S+ + + S +
Sbjct: 1125 KTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDN 1184
Query: 722 AYSRGITKENEREG 735
+ +R ENE+ G
Sbjct: 1185 SLNRSPRSENEKPG 1198
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 91.3 bits (225), Expect = 4e-18
Identities = 57/191 (29%), Positives = 98/191 (51%), Gaps = 10/191 (5%)
Query: 3 KFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEE 62
+ L+++GA ++ + EGW PLH AA + ++A L+ + A +EG TPL +A
Sbjct: 445 RLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYF 504
Query: 63 AMEELLQNEVNRQGVDIEAARKE--------EERIMLRDARQWLNSGHINDVRHAKSGGT 114
L++ + QG +++A ++ ER +R + L SG + D +SG
Sbjct: 505 GHVSLVKL-LTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALD-QSGYG 562
Query: 115 ALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMV 174
LH AAA+G + K+L++ G + + + GWTPLH AA+ G E +L ++ +M +
Sbjct: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGAL 622
Query: 175 NKVGQTAFDVA 185
V T +A
Sbjct: 623 GAVNWTPLHLA 633
Score = 76.6 bits (187), Expect = 1e-13
Identities = 54/163 (33%), Positives = 82/163 (50%), Gaps = 8/163 (4%)
Query: 3 KFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEE 62
K L+ GA++ P ++GW PLH AA G+L+I L A++GA+ + TPL +A
Sbjct: 577 KMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARH 636
Query: 63 AMEELLQNEVNRQGVDIEAARKEE-ERIMLRDARQW------LNSGHINDVRHAKSGGTA 115
EE + + + + G D AA + + L R L H N K G T
Sbjct: 637 G-EEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTP 695
Query: 116 LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKE 158
H+AA KG T +LK+L++AG ++++D TPL A K+
Sbjct: 696 AHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQ 738
Score = 57.0 bits (136), Expect = 8e-08
Identities = 44/186 (23%), Positives = 77/186 (41%), Gaps = 27/186 (14%)
Query: 2 VKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEE 61
V+ L+ + +++ G+ PL AA D+ L+ GA V+ +G PL A +
Sbjct: 378 VRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQ 437
Query: 62 EAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAA 121
+ AR L+ G D + + G T LH+AA
Sbjct: 438 NGDDGT--------------------------ARLLLDHGACVDAQE-REGWTPLHLAAQ 470
Query: 122 KGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTA 181
+ V +LL+ D N+ + +G TPLH AA++G ++L +++ + +T
Sbjct: 471 NNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTP 530
Query: 182 FDVADE 187
+A E
Sbjct: 531 LHLAVE 536
Score = 49.7 bits (117), Expect = 1e-05
Identities = 36/108 (33%), Positives = 52/108 (48%), Gaps = 7/108 (6%)
Query: 111 SGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCD 170
SG T L +AA ++ LL+ G D N D DGW PLH AA G + R+L+D+
Sbjct: 394 SGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGAC 453
Query: 171 MEMVNKVGQTAFDVAD----EDILGYLEELQKKQNLLHSEKRDKKSPL 214
++ + G T +A E++ L Q NL +E K+PL
Sbjct: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAE---GKTPL 498
Score = 38.1 bits (87), Expect = 0.039
Identities = 21/65 (32%), Positives = 35/65 (53%)
Query: 114 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 173
T LH A+G E ++LL+ DV+ + G+TPL AA + + C +L+ + D
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 174 VNKVG 178
V++ G
Sbjct: 424 VDEDG 428
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 90.1 bits (222), Expect = 9e-18
Identities = 107/620 (17%), Positives = 236/620 (38%), Gaps = 39/620 (6%)
Query: 204 HSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKK 263
+S + S +S ++ ++ S + ++ ++S
Sbjct: 697 NSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSS 756
Query: 264 DESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSP 323
D S S+ D D S+S +D + +S +N +++S+ ++ + ++ + +S ++ +S
Sbjct: 757 DSSDSSNSSDSSDSSDSSDSSDSSN--SSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSD 814
Query: 324 IKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRS 383
++ + S + D S ++ S G+ ++ + + D++ + S
Sbjct: 815 SSDSDSSNSSDSSNSSDSSDSSNSSDSSD-SSDSSDGSDSDSSNRSDSSNSSDSSDSSDS 873
Query: 384 ASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTR 443
++S S S D+ E S + + +S SD + N SS ++SS +
Sbjct: 874 SNSSDSSDSSDSNESSNSSDSSDSSN---------SSDSDSSDSSNSSDSSDSSNSSDSS 924
Query: 444 RKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSST 503
NSS + S+ S D +SS S +S + ++++ S SS
Sbjct: 925 ESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSD 984
Query: 504 STTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTT 563
S+ + ++ SS + S++S+ + DS++ S + N++ S+ + +
Sbjct: 985 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSS-----------NSSDSSNSSDS 1033
Query: 564 TTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKT 623
+ + S +++ + S + + S+S + S + S S+ +D ++ +
Sbjct: 1034 SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNS 1093
Query: 624 IGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYR 683
S S+ + + + + + D + +S S + S + D +
Sbjct: 1094 SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSES--- 1150
Query: 684 PVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKE 743
S SS ++ SS S S S +S + NS S+ + + +
Sbjct: 1151 --SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSS-----------DSSDSSDSSD 1197
Query: 744 GEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRY 803
D S + + S+ S + SD NE SD+ + S+ + S S
Sbjct: 1198 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSD 1257
Query: 804 ETSSTSAGDRYDSLLGRSGS 823
+ STS + +SG+
Sbjct: 1258 SSDSTSDSNDESDSQSKSGN 1277
Score = 89.7 bits (221), Expect = 1e-17
Identities = 115/657 (17%), Positives = 250/657 (38%), Gaps = 28/657 (4%)
Query: 197 QKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVD 256
+ K N S+ + + +ST++ +N+ S N + +K+ S + D
Sbjct: 497 ESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGND---DNDKSDSGKGKSDSSDSD 553
Query: 257 EEEEGKKDESSCSSEEDEED-DSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSS 315
+ +SS SS+ D D +S S++++ + S + ++ S+ ++ + ++ + S
Sbjct: 554 SSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDS 613
Query: 316 GQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEK 375
++ +S K + + S + + D S + + S + + + S +
Sbjct: 614 SDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDS-SNSSNSSDSSDSS 672
Query: 376 DTAGVTRSASSPRLSSSLD-----NKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENR 430
D++ + S+ S S S D N + DS + + + + +++SD + +
Sbjct: 673 DSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSS 732
Query: 431 DSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVT 490
DSS SS + + +S ++ S S D SS+ + + +
Sbjct: 733 DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSS 792
Query: 491 SAAGLQKSLLSSTSTTTKITTGSSSAGTQSS--TSNRLWAEDSTEKEKDSVPTAVTIPVA 548
++ S SS S+ + ++ SS + + +S +SN + DS+ S + +
Sbjct: 793 DSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSD 852
Query: 549 PTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRS 608
N + S+ + ++ + S++++ + S+S + S + S S
Sbjct: 853 SDSSNRSDSSNSSDSSDSSDSSNSSD------------SSDSSDSNESSNSSDSSDSSNS 900
Query: 609 TQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYK 668
+ + +D + + S S+ + E N + + + +S S +
Sbjct: 901 SDSDS-SDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNS 959
Query: 669 QKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSA-YSRGI 727
S + D + S SS+++ SS S S S +S N +S S+ S
Sbjct: 960 SDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSS 1019
Query: 728 TKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTE 787
N + + + D S + + S+ S + SD ++ SD+
Sbjct: 1020 DSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1079
Query: 788 EGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTD 844
+ S ++ S S + S+ + D DS S S + S + DS+D
Sbjct: 1080 DSSESSDSSDSSNSSDSSDSSDSSDSSDS--SDSSDSSDSSDSSNSSDSSDSSDSSD 1134
Score = 55.5 bits (132), Expect = 2e-07
Identities = 115/636 (18%), Positives = 209/636 (32%), Gaps = 56/636 (8%)
Query: 239 EPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANT 298
E E+ + +S K E ++ K++ SS D E K P V T
Sbjct: 263 EDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKT 322
Query: 299 SSTQAAPVAVT----TPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLR 354
S ++ + + + Q K+ TK S K + G
Sbjct: 323 SKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKG-P 381
Query: 355 KTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEK--EKDSKGTRLAYVAP 412
+G+ E+ EG+++K G+ + + + N E +K G ++ +
Sbjct: 382 SSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNT 441
Query: 413 TIPRRLASTSDIEEKENRDSSSLRTS--SSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGR 470
S SD + + D S++ +S DD S N S S +
Sbjct: 442 GSD----SNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDE 497
Query: 471 RQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAED 530
+D+ S K S +T T S S G ++ ++ D
Sbjct: 498 SKDNGNGSD----------------SKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSD 541
Query: 531 STEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEE 590
S + + DS + + N++ S+ + + ++ + SS+ S + D
Sbjct: 542 SGKGKSDSSDSD-----SSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSS 596
Query: 591 SESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDK 650
S S + S S + ++ K+ S + ++ ++ + + D
Sbjct: 597 DSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDS 656
Query: 651 EKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYAS--S 708
S S + S + D + S+ SS + SS S+ SS +S S
Sbjct: 657 SDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSS 716
Query: 709 QLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGV 768
+ NS +S S N + + D S + S+
Sbjct: 717 DSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDS 776
Query: 769 SFWTQDSDENEQEQQSDTEEGSNKKETQ-----------TDSISRYETSSTSAGDRYDSL 817
S + SD N+ SD+ + SN ++ +DS S + S+++ D DS
Sbjct: 777 SDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSS 836
Query: 818 L---------GRSGSYSYLEERKPYSSRLEKDDSTD 844
GS S R S+ + DS+D
Sbjct: 837 NSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSD 872
Score = 35.4 bits (80), Expect = 0.25
Identities = 38/197 (19%), Positives = 78/197 (39%), Gaps = 8/197 (4%)
Query: 657 KESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSL 716
++SE + + S + + Y Y S +S + + A+S+ + +S
Sbjct: 428 QKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSS 487
Query: 717 VGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRR-------PREKRRSTGVS 769
G S Y+ +K+N + + E + D + + + +K S
Sbjct: 488 RGDAS-YNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGK 546
Query: 770 FWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEE 829
+ DSD ++ SD+ + S+ + ++S S ++S + + D DS S + S +
Sbjct: 547 SDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSD 606
Query: 830 RKPYSSRLEKDDSTDFK 846
S + DS+D K
Sbjct: 607 SSDSSDSSDSSDSSDSK 623
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 88.6 bits (218), Expect = 3e-17
Identities = 60/185 (32%), Positives = 88/185 (47%), Gaps = 27/185 (14%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+V+FL++ G +N D+ GW PLH AAS G +I + L+G+GA V AVN G TPL A
Sbjct: 55 IVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAA 114
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
+ E+ +ML + G N TA+H AA
Sbjct: 115 SKNRHEIA--------------------VMLLE-------GGANPDAKDHYEATAMHRAA 147
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
AKG +++ +L+ NI+D +G TPLH A + E ++LV + + NK +T
Sbjct: 148 AKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKT 207
Query: 181 AFDVA 185
VA
Sbjct: 208 PLQVA 212
Score = 59.7 bits (143), Expect = 1e-08
Identities = 30/72 (41%), Positives = 43/72 (59%)
Query: 114 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 173
TALH A + G+TE+++ L+Q G VN KD GW+PLH AA G++E + L+ +
Sbjct: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
Query: 174 VNKVGQTAFDVA 185
VN+ G T A
Sbjct: 102 VNQNGCTPLHYA 113
Score = 59.3 bits (142), Expect = 2e-08
Identities = 49/200 (24%), Positives = 88/200 (44%), Gaps = 28/200 (14%)
Query: 16 DNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQ 75
D + LH A S G+ +I EFL+ G V + G +PL IA +E+++ + +
Sbjct: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK- 95
Query: 76 GVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAG 135
G + A + +G T LH AA+K E+ +L++ G
Sbjct: 96 GAQVNAVNQ--------------------------NGCTPLHYAASKNRHEIAVMLLEGG 129
Query: 136 YDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA-DEDILGYLE 194
+ + KD+ T +H AA G + IL+ + + G T +A DE+ + +
Sbjct: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAK 189
Query: 195 ELQKKQNLLHSEKRDKKSPL 214
L + ++ E +++K+PL
Sbjct: 190 LLVSQGASIYIENKEEKTPL 209
Score = 40.4 bits (93), Expect = 0.008
Identities = 22/60 (36%), Positives = 32/60 (53%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
M+ L+ A+ N D EG PLH A ++ A+ L+ QGA + N E TPL +A+
Sbjct: 154 MIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 88.2 bits (217), Expect = 3e-17
Identities = 124/508 (24%), Positives = 215/508 (42%), Gaps = 53/508 (10%)
Query: 1 MVKFLVENGANINQPDNE--GWIPLHAAASCGYLDIAEFLIGQGAHVGA-VNSEGDTPLD 57
++K L+ GA IN G PL AA G++ + L+ G+ + A + + +T L
Sbjct: 1170 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALT 1229
Query: 58 IAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDA--------RQWLNSG-HINDVRH 108
+A + E++ ++R+ ++E K ++ A R L+ G +N
Sbjct: 1230 LACFQGRAEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1288
Query: 109 AKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNL 168
S TAL +AA KG+ + +LLI G +++++ G TPL A++ G + ++LV
Sbjct: 1289 PSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAG 1348
Query: 169 CDMEMVNKVGQT----AFDVADEDILGYL-----------EELQKKQNLLHSEKRDKKSP 213
D++ + T AF ++ YL E ++ + E K
Sbjct: 1349 ADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQ 1408
Query: 214 LIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQ------EKVDEEEEGKKDESS 267
+E+ + Q+ + KN L+ E + SR ES +Q EK E+ + KK+E
Sbjct: 1409 CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQK 1468
Query: 268 CSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPT---VSSGQATPTSPI 324
EEDEE+ + +E + + P + TT T +S+ AT T+
Sbjct: 1469 RKQEEDEENKPKENSELPEDEDEEENDEDVEQEVPIEPPSATTTTTIGISATSATFTNVF 1528
Query: 325 -KKFPTTATKISPKEEERKD---ESPATWRLGLRKTGSYGALAEITASKEG-QKEKDTAG 379
KK T S + +K+ E+P T L L + + +LA+ A K E G
Sbjct: 1529 GKKRANVVTTPSTNRKNKKNKTKETPPTAHLILPE--QHMSLAQQKADKNKINGEPRGGG 1586
Query: 380 VTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSS 439
++ S L S+ N E K L +V + S + +E + S T++
Sbjct: 1587 AGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDVNSSKYPSLL-LHSQEEKTS----TAT 1641
Query: 440 SYTRRKWEDDLKKNSSVNEGSTYHKSCS 467
S T+ + E ++ NS ST +K+ S
Sbjct: 1642 SKTQTRLEGEVTPNSL----STSYKTVS 1665
Score = 70.5 bits (171), Expect = 7e-12
Identities = 64/221 (28%), Positives = 103/221 (46%), Gaps = 36/221 (16%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ + L+++GA +N P + PL AA G++++A LI +GA++ VN EG TPL A
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
E EE++ + QG +I A +E + TAL +A
Sbjct: 480 REGHEEMVA-LLLAQGANINAQTEETQE-------------------------TALTLAC 513
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
G++EV LI+AG D+ + TPL A+ G E + L+ + ++ G T
Sbjct: 514 CGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDT 570
Query: 181 AFDVADE----DILGYLEELQKKQNLLHSEKRDKKSPLIES 217
A A E D+ L LQ +L H E ++PL+++
Sbjct: 571 ALTYACENGHTDVADVL--LQAGADLEH-ESEGGRTPLMKA 608
Score = 64.7 bits (156), Expect = 4e-10
Identities = 53/192 (27%), Positives = 89/192 (46%), Gaps = 17/192 (8%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+VK L+ + A++N G L A + G++DI + L+ +GA++ N G TPL A
Sbjct: 287 IVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAA 346
Query: 61 EEAMEELLQNEVNR-QGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGG------ 113
E+ + ++ G++ + +E + L + GH++ VR G
Sbjct: 347 SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK-----GHLDMVRFLLEAGADQEHK 401
Query: 114 -----TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNL 168
TAL A G+ EV +LL+ +G VN+ +PL AA G E +L++
Sbjct: 402 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 461
Query: 169 CDMEMVNKVGQT 180
++E VN G T
Sbjct: 462 ANLEEVNDEGYT 473
Score = 61.2 bits (147), Expect = 4e-09
Identities = 47/167 (28%), Positives = 82/167 (49%), Gaps = 28/167 (16%)
Query: 2 VKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD-TPLDIAE 60
V+ L++ G ++N+ EG L A S GY ++A+ L+ A+V ++GD TPL A
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
++++ ++L DA +NS + +G TAL A
Sbjct: 281 SGGYLDIVK------------------LLLLHDAD--VNS-------QSATGNTALTYAC 313
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 167
A G+ +++K+L+ G ++ + +G TPL AA G E R+L+D+
Sbjct: 314 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Score = 44.3 bits (103), Expect = 5e-04
Identities = 31/144 (21%), Positives = 75/144 (52%), Gaps = 16/144 (11%)
Query: 582 YLTPVRDEES--------ESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRST--- 630
Y+ + D+E E+ KA+ +QA ++ ++ + L +L + EK+ SR
Sbjct: 1393 YIATITDKELLKKCHQCVETIVKAKDQQAAEANKNAS-ILLKEL-DLEKSREESRKQALA 1450
Query: 631 ---RTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVST 687
R+++ ++K++E+K KQ+++++ + KE+ EDE +++ ++ P +T
Sbjct: 1451 AKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQEVPIEPPSAT 1510
Query: 688 SSSTTPSSSLSTMSSSLYASSQLN 711
+++T S+ S ++++ + N
Sbjct: 1511 TTTTIGISATSATFTNVFGKKRAN 1534
Score = 39.7 bits (91), Expect = 0.013
Identities = 43/180 (23%), Positives = 72/180 (40%), Gaps = 29/180 (16%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ + EN N Q D L A S G ++ L+ +G V EG++ L +A
Sbjct: 190 LTRMKAENSHNAGQVDTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLAC 246
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
EL Q ++L + G+ D+ T L A+
Sbjct: 247 SAGYYELAQ-------------------VLLAMHANVEDRGNKGDI-------TPLMAAS 280
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
+ GY +++KLL+ DVN + G T L A G + ++L++ ++E N+ G T
Sbjct: 281 SGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340
Score = 36.6 bits (83), Expect = 0.11
Identities = 23/68 (33%), Positives = 34/68 (50%)
Query: 105 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 164
D + TAL +A A G+ E++ +LI + +D G+TPL AA G IL
Sbjct: 1048 DAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107
Query: 165 VDNLCDME 172
+D D+E
Sbjct: 1108 LDKGGDIE 1115
Score = 34.7 bits (78), Expect = 0.43
Identities = 17/49 (34%), Positives = 26/49 (53%)
Query: 5 LVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD 53
L++ GA++ G PL AA G+L +FLI +GA+V + D
Sbjct: 587 LLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANND 635
Score = 34.3 bits (77), Expect = 0.56
Identities = 46/183 (25%), Positives = 76/183 (41%), Gaps = 8/183 (4%)
Query: 9 GANINQPDNEGWIPLHA---AASCGYLDIAEFLIGQGAHV-GAVNSEGDTPLDIAEEEAM 64
GA++ D E L A AA G L A+ V + S LD A
Sbjct: 132 GADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALT 191
Query: 65 EELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGH-INDVRHAKSGGTALHVAAAKG 123
+N N VD + + + R+ L+ G +N+ H + G + L +A + G
Sbjct: 192 RMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNE--HTEEGESLLCLACSAG 249
Query: 124 YTEVLKLLIQAGYDVNIKDYDG-WTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAF 182
Y E+ ++L+ +V + G TPL AA+ G + ++L+ + D+ + G TA
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
Query: 183 DVA 185
A
Sbjct: 310 TYA 312
Score = 31.6 bits (70), Expect = 3.6
Identities = 16/81 (19%), Positives = 38/81 (46%)
Query: 261 GKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATP 320
G + SS +++ EA+ L+ ++ S+++ AP+ +T+P + +
Sbjct: 2060 GAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNSEPAPLTLTSPRMVAADNQD 2119
Query: 321 TSPIKKFPTTATKISPKEEER 341
TS + + A ++S + + R
Sbjct: 2120 TSNLPQLAVPAPRVSHRMQPR 2140
Score = 30.4 bits (67), Expect = 8.1
Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 1/56 (1%)
Query: 2 VKFLVENGANINQPD-NEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPL 56
V+FL+ GAN+N+ N + A + G+L + E L+ GA +G T L
Sbjct: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 672
Score = 30.4 bits (67), Expect = 8.1
Identities = 20/86 (23%), Positives = 39/86 (45%), Gaps = 10/86 (11%)
Query: 725 RGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQS 784
+ + + E+ EKR+++KE + + Q + E +P+E DE+E+E
Sbjct: 1447 QALAAKREKRKEKRKKKKEEQKRKQEED--EENKPKENSELP--------EDEDEEENDE 1496
Query: 785 DTEEGSNKKETQTDSISRYETSSTSA 810
D E+ + + + S+TSA
Sbjct: 1497 DVEQEVPIEPPSATTTTTIGISATSA 1522
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 88.2 bits (217), Expect = 3e-17
Identities = 124/508 (24%), Positives = 215/508 (42%), Gaps = 53/508 (10%)
Query: 1 MVKFLVENGANINQPDNE--GWIPLHAAASCGYLDIAEFLIGQGAHVGA-VNSEGDTPLD 57
++K L+ GA IN G PL AA G++ + L+ G+ + A + + +T L
Sbjct: 1170 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALT 1229
Query: 58 IAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDA--------RQWLNSG-HINDVRH 108
+A + E++ ++R+ ++E K ++ A R L+ G +N
Sbjct: 1230 LACFQGRAEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1288
Query: 109 AKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNL 168
S TAL +AA KG+ + +LLI G +++++ G TPL A++ G + ++LV
Sbjct: 1289 PSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAG 1348
Query: 169 CDMEMVNKVGQT----AFDVADEDILGYL-----------EELQKKQNLLHSEKRDKKSP 213
D++ + T AF ++ YL E ++ + E K
Sbjct: 1349 ADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQ 1408
Query: 214 LIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQ------EKVDEEEEGKKDESS 267
+E+ + Q+ + KN L+ E + SR ES +Q EK E+ + KK+E
Sbjct: 1409 CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQK 1468
Query: 268 CSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPT---VSSGQATPTSPI 324
EEDEE+ + +E + + P + TT T +S+ AT T+
Sbjct: 1469 RKQEEDEENKPKENSELPEDEDEEENDEDVEQEVPIEPPSATTTTTIGISATSATFTNVF 1528
Query: 325 -KKFPTTATKISPKEEERKD---ESPATWRLGLRKTGSYGALAEITASKEG-QKEKDTAG 379
KK T S + +K+ E+P T L L + + +LA+ A K E G
Sbjct: 1529 GKKRANVVTTPSTNRKNKKNKTKETPPTAHLILPE--QHMSLAQQKADKNKINGEPRGGG 1586
Query: 380 VTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSS 439
++ S L S+ N E K L +V + S + +E + S T++
Sbjct: 1587 AGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDVNSSKYPSLL-LHSQEEKTS----TAT 1641
Query: 440 SYTRRKWEDDLKKNSSVNEGSTYHKSCS 467
S T+ + E ++ NS ST +K+ S
Sbjct: 1642 SKTQTRLEGEVTPNSL----STSYKTVS 1665
Score = 70.5 bits (171), Expect = 7e-12
Identities = 64/221 (28%), Positives = 103/221 (46%), Gaps = 36/221 (16%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ + L+++GA +N P + PL AA G++++A LI +GA++ VN EG TPL A
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
E EE++ + QG +I A +E + TAL +A
Sbjct: 480 REGHEEMVA-LLLAQGANINAQTEETQE-------------------------TALTLAC 513
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
G++EV LI+AG D+ + TPL A+ G E + L+ + ++ G T
Sbjct: 514 CGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDT 570
Query: 181 AFDVADE----DILGYLEELQKKQNLLHSEKRDKKSPLIES 217
A A E D+ L LQ +L H E ++PL+++
Sbjct: 571 ALTYACENGHTDVADVL--LQAGADLEH-ESEGGRTPLMKA 608
Score = 64.7 bits (156), Expect = 4e-10
Identities = 53/192 (27%), Positives = 89/192 (46%), Gaps = 17/192 (8%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+VK L+ + A++N G L A + G++DI + L+ +GA++ N G TPL A
Sbjct: 287 IVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAA 346
Query: 61 EEAMEELLQNEVNR-QGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGG------ 113
E+ + ++ G++ + +E + L + GH++ VR G
Sbjct: 347 SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK-----GHLDMVRFLLEAGADQEHK 401
Query: 114 -----TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNL 168
TAL A G+ EV +LL+ +G VN+ +PL AA G E +L++
Sbjct: 402 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 461
Query: 169 CDMEMVNKVGQT 180
++E VN G T
Sbjct: 462 ANLEEVNDEGYT 473
Score = 61.2 bits (147), Expect = 4e-09
Identities = 47/167 (28%), Positives = 82/167 (49%), Gaps = 28/167 (16%)
Query: 2 VKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD-TPLDIAE 60
V+ L++ G ++N+ EG L A S GY ++A+ L+ A+V ++GD TPL A
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
++++ ++L DA +NS + +G TAL A
Sbjct: 281 SGGYLDIVK------------------LLLLHDAD--VNS-------QSATGNTALTYAC 313
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 167
A G+ +++K+L+ G ++ + +G TPL AA G E R+L+D+
Sbjct: 314 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Score = 44.3 bits (103), Expect = 5e-04
Identities = 31/144 (21%), Positives = 75/144 (52%), Gaps = 16/144 (11%)
Query: 582 YLTPVRDEES--------ESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRST--- 630
Y+ + D+E E+ KA+ +QA ++ ++ + L +L + EK+ SR
Sbjct: 1393 YIATITDKELLKKCHQCVETIVKAKDQQAAEANKNAS-ILLKEL-DLEKSREESRKQALA 1450
Query: 631 ---RTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVST 687
R+++ ++K++E+K KQ+++++ + KE+ EDE +++ ++ P +T
Sbjct: 1451 AKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQEVPIEPPSAT 1510
Query: 688 SSSTTPSSSLSTMSSSLYASSQLN 711
+++T S+ S ++++ + N
Sbjct: 1511 TTTTIGISATSATFTNVFGKKRAN 1534
Score = 39.7 bits (91), Expect = 0.013
Identities = 43/180 (23%), Positives = 72/180 (40%), Gaps = 29/180 (16%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ + EN N Q D L A S G ++ L+ +G V EG++ L +A
Sbjct: 190 LTRMKAENSHNAGQVDTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLAC 246
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
EL Q ++L + G+ D+ T L A+
Sbjct: 247 SAGYYELAQ-------------------VLLAMHANVEDRGNKGDI-------TPLMAAS 280
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
+ GY +++KLL+ DVN + G T L A G + ++L++ ++E N+ G T
Sbjct: 281 SGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340
Score = 36.6 bits (83), Expect = 0.11
Identities = 23/68 (33%), Positives = 34/68 (50%)
Query: 105 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 164
D + TAL +A A G+ E++ +LI + +D G+TPL AA G IL
Sbjct: 1048 DAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107
Query: 165 VDNLCDME 172
+D D+E
Sbjct: 1108 LDKGGDIE 1115
Score = 34.7 bits (78), Expect = 0.43
Identities = 17/49 (34%), Positives = 26/49 (53%)
Query: 5 LVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD 53
L++ GA++ G PL AA G+L +FLI +GA+V + D
Sbjct: 587 LLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANND 635
Score = 34.3 bits (77), Expect = 0.56
Identities = 46/183 (25%), Positives = 76/183 (41%), Gaps = 8/183 (4%)
Query: 9 GANINQPDNEGWIPLHA---AASCGYLDIAEFLIGQGAHV-GAVNSEGDTPLDIAEEEAM 64
GA++ D E L A AA G L A+ V + S LD A
Sbjct: 132 GADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALT 191
Query: 65 EELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGH-INDVRHAKSGGTALHVAAAKG 123
+N N VD + + + R+ L+ G +N+ H + G + L +A + G
Sbjct: 192 RMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNE--HTEEGESLLCLACSAG 249
Query: 124 YTEVLKLLIQAGYDVNIKDYDG-WTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAF 182
Y E+ ++L+ +V + G TPL AA+ G + ++L+ + D+ + G TA
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
Query: 183 DVA 185
A
Sbjct: 310 TYA 312
Score = 31.6 bits (70), Expect = 3.6
Identities = 16/81 (19%), Positives = 38/81 (46%)
Query: 261 GKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATP 320
G + SS +++ EA+ L+ ++ S+++ AP+ +T+P + +
Sbjct: 2060 GAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNSEPAPLTLTSPRMVAADNQD 2119
Query: 321 TSPIKKFPTTATKISPKEEER 341
TS + + A ++S + + R
Sbjct: 2120 TSNLPQLAVPAPRVSHRMQPR 2140
Score = 30.4 bits (67), Expect = 8.1
Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 1/56 (1%)
Query: 2 VKFLVENGANINQPD-NEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPL 56
V+FL+ GAN+N+ N + A + G+L + E L+ GA +G T L
Sbjct: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 672
Score = 30.4 bits (67), Expect = 8.1
Identities = 20/86 (23%), Positives = 39/86 (45%), Gaps = 10/86 (11%)
Query: 725 RGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQS 784
+ + + E+ EKR+++KE + + Q + E +P+E DE+E+E
Sbjct: 1447 QALAAKREKRKEKRKKKKEEQKRKQEED--EENKPKENSELP--------EDEDEEENDE 1496
Query: 785 DTEEGSNKKETQTDSISRYETSSTSA 810
D E+ + + + S+TSA
Sbjct: 1497 DVEQEVPIEPPSATTTTTIGISATSA 1522
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 88.2 bits (217), Expect = 3e-17
Identities = 142/562 (25%), Positives = 223/562 (39%), Gaps = 111/562 (19%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGA--VNSEGDTPLDI 58
+V L++ AN+ G PL AAS GY ++ L+ +GA V A V S DT L I
Sbjct: 1267 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1326
Query: 59 AEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHV 118
A ++ + + + R HI DVR+ K G T L +
Sbjct: 1327 AADKGHYKFCELLIGR-------------------------GAHI-DVRN-KKGNTPLWL 1359
Query: 119 AAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVG 178
AA G+ +V++LL+QAG DV+ D TPL AA G + R LV + VN+
Sbjct: 1360 AANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV------KEVNQF- 1412
Query: 179 QTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPL-IESTANMDNNQSQKTFKNKETLI 237
+D + + Y+ + K+ L KK L +ES + Q+ + KN L+
Sbjct: 1413 -----PSDSECMRYIATITDKEML-------KKCHLCMESIVQAKDRQAAEANKNASILL 1460
Query: 238 IEPEKNASRIES------LEQEKVDEEEEGKKDESSCSSEEDEEDDSES-EAETDKTKPL 290
E + R ES ++EK E+ KK+E EE E + E+ E + + K
Sbjct: 1461 EELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEK 1520
Query: 291 ASVTNANTSSTQAAPVAVTTPT--VSSGQATPTSPIKKFPTTATKISPKEEERKDE-SPA 347
V + T+ P A TT T +S+ T K T T S K + RK++ +P
Sbjct: 1521 LKVEDEPEVLTE-PPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPE 1579
Query: 348 TWRLGLRK--TGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLD---NKEKEKDS 402
++ SY ++ G+ + + + + + R+SS D N + S
Sbjct: 1580 NVQIIFDDPLPISYSQPEKV----NGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKS 1635
Query: 403 KGTRLAYVAPTI-PRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGST 461
A V T+ ++ S KE R S S + S +K + +++EG++
Sbjct: 1636 DNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKAS-----------IKLSETISEGTS 1684
Query: 462 YHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSS 521
S + S PS S+P K+T S G +
Sbjct: 1685 NSLS---------TCTKSGPSPLSSP------------------NGKLTVASPKRGQKRE 1717
Query: 522 TSNRLWAEDSTEKEKDSVPTAV 543
W E +K SVP+ V
Sbjct: 1718 EG---WKEVVRRSKKVSVPSTV 1736
Score = 69.3 bits (168), Expect = 2e-11
Identities = 65/221 (29%), Positives = 100/221 (45%), Gaps = 36/221 (16%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ + L+++GA +N P + PL AA G++++A LI +GA + VN EG TPL A
Sbjct: 449 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAA 508
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
E EE++ + QG +I A +E + TAL +A
Sbjct: 509 REGHEEMVALLLG-QGANINAQTEETQE-------------------------TALTLAC 542
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
G+ EV LI+AG D+ + TPL AA G E + L+ ++ G T
Sbjct: 543 CGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDT 599
Query: 181 AFDVADE----DILGYLEELQKKQNLLHSEKRDKKSPLIES 217
A A E D+ L LQ +L H E ++PL+++
Sbjct: 600 ALTYACENGHTDVADVL--LQAGADLEH-ESEGGRTPLMKA 637
Score = 64.7 bits (156), Expect = 4e-10
Identities = 54/192 (28%), Positives = 86/192 (44%), Gaps = 17/192 (8%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+VK L+ + A++N + G L A + GY+D+ + L+ GA + N G TPL A
Sbjct: 316 IVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAG 375
Query: 61 EEAMEELLQNEV-NRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGG------ 113
E+ + + N G++ + +E + L + GH+ VR G
Sbjct: 376 SAGHVEVARLLLENGAGINTHSNEFKESALTLACYK-----GHLEMVRFLLEAGADQEHK 430
Query: 114 -----TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNL 168
TAL A G+ EV +LL+ +G VN+ +PL AA G E +L++
Sbjct: 431 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 490
Query: 169 CDMEMVNKVGQT 180
+E VN G T
Sbjct: 491 ASLEEVNDEGYT 502
Score = 61.6 bits (148), Expect = 3e-09
Identities = 62/214 (28%), Positives = 95/214 (44%), Gaps = 43/214 (20%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEG-DTPLDIA 59
+V+ L+E GA+I D +G+ PL AA+ G++ + E L+ GA + A + DTPL +A
Sbjct: 1098 LVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLA 1157
Query: 60 ----EEEAMEELLQNEVNRQGVDIE-------AARKEEERIM--LRDARQWLNS------ 100
+E +E LL N++ ++ AA I+ L +A +NS
Sbjct: 1158 CSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKL 1217
Query: 101 -----------GHINDVRHAKSGG------------TALHVAAAKGYTEVLKLLIQAGYD 137
GH V+ G TAL +A +G TEV+ LL+ +
Sbjct: 1218 GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKAN 1277
Query: 138 VNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDM 171
V + G TPL AA G E R+L+D D+
Sbjct: 1278 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311
Score = 57.8 bits (138), Expect = 5e-08
Identities = 48/167 (28%), Positives = 76/167 (45%), Gaps = 31/167 (18%)
Query: 3 KFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD-TPLDIAEE 61
K L+E G ++N+ EG L A S GY ++A+ L+ A+V +GD TPL A
Sbjct: 252 KLLIE-GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAAN 310
Query: 62 EAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVR-HAKSGGTALHVAA 120
++++ L H DV + +G TAL A
Sbjct: 311 GGHVKIVK----------------------------LLLAHKADVNAQSSTGNTALTYAC 342
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 167
A GY +V+K+L+++G + + +G TPL A G E R+L++N
Sbjct: 343 AGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN 389
Score = 49.7 bits (117), Expect = 1e-05
Identities = 57/216 (26%), Positives = 100/216 (46%), Gaps = 27/216 (12%)
Query: 23 LHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEE----AMEELLQNEVNRQGVD 78
L A + G+ ++ + L+ +GA + + +G TPL +A +E LL N G D
Sbjct: 1087 LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN-----GAD 1141
Query: 79 IEAARKEEERIML--------RDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKL 130
IEA + + L ++ + L + N S T L +AA+ GY ++K+
Sbjct: 1142 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1201
Query: 131 LIQAGYDVNIKDYD--GWTPLHAAAHWGKEEACRILVDNLCDME-MVNKVGQTAFDVA-- 185
L+ AG ++N + G +PL AA G A ++L+D D+ + TA +A
Sbjct: 1202 LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACF 1261
Query: 186 --DEDILGYLEELQKKQNLLHSEKRDKKSPLIESTA 219
+++ L L +K N+ H K +PL+E+ +
Sbjct: 1262 QGRTEVVSLL--LDRKANVEHRAKTG-LTPLMEAAS 1294
Score = 43.5 bits (101), Expect = 0.001
Identities = 24/68 (35%), Positives = 38/68 (55%)
Query: 105 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 164
D + + TAL +A A G+ E+++ L++ G + +D G+TPL AA G IL
Sbjct: 1076 DAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEIL 1135
Query: 165 VDNLCDME 172
+DN D+E
Sbjct: 1136 LDNGADIE 1143
Score = 40.8 bits (94), Expect = 0.006
Identities = 55/268 (20%), Positives = 116/268 (43%), Gaps = 31/268 (11%)
Query: 582 YLTPVRDEES--------ESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTR 633
Y+ + D+E ES +A+ RQA ++ ++ + L+E + R S R
Sbjct: 1421 YIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASIL----LEELDLEKLREESRRLA 1476
Query: 634 EQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRP----VSTSS 689
EK KE++ K+ +E++ + +E E ++ ++ + ++ ++ P S+
Sbjct: 1477 LAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSA 1536
Query: 690 STTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQ 749
+TT + +S ++L A S R N++ +S ++N + E + D
Sbjct: 1537 TTTTTIGISATWTTL-AGSHGKRNNTITTTSS------KRKNRKNKITPENVQIIFDDPL 1589
Query: 750 PKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKET-QTDSISRYETSST 808
P S + + + +S+ S + D + S ++E SN + ++D+ S ++T
Sbjct: 1590 PISYSQPEKVNGESKSSSTS---ESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTT 1646
Query: 809 SAGDRYDSLLGRSGSYSYLEERKPYSSR 836
+ + S+L EERK S +
Sbjct: 1647 VSSKKQPSVLVTFPK----EERKSVSGK 1670
Score = 39.7 bits (91), Expect = 0.013
Identities = 46/181 (25%), Positives = 72/181 (39%), Gaps = 31/181 (17%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ + E+ AN Q DN L A S G ++ L+ +G V EG++ L +A
Sbjct: 219 LTRMRAESTANAGQSDNRS---LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLAC 275
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHIN-DVRHAKSGGTALHVA 119
EL Q L + H N + R K T L A
Sbjct: 276 SAGYYELAQV---------------------------LLAMHANVEDRGIKGDITPLMAA 308
Query: 120 AAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQ 179
A G+ +++KLL+ DVN + G T L A G + ++L+++ +E N+ G
Sbjct: 309 ANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGH 368
Query: 180 T 180
T
Sbjct: 369 T 369
Score = 37.4 bits (85), Expect = 0.066
Identities = 28/106 (26%), Positives = 49/106 (46%), Gaps = 12/106 (11%)
Query: 92 RDARQWLNSGHINDVR-----------HAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNI 140
R + + G +N VR H + G + L +A + GY E+ ++L+ +V
Sbjct: 236 RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 295
Query: 141 KDYDG-WTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 185
+ G TPL AAA+ G + ++L+ + D+ + G TA A
Sbjct: 296 RGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341
Score = 35.8 bits (81), Expect = 0.19
Identities = 64/290 (22%), Positives = 108/290 (37%), Gaps = 38/290 (13%)
Query: 5 LVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD-TPLDIA---E 60
L++ GA++ G PL AA G++ +FLI +GA+V + D T L +A
Sbjct: 616 LLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGG 675
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRH-AKSGGTALHVA 119
A+ ELL H D H K G T L A
Sbjct: 676 HLAVVELL-------------------------------LAHGADPTHRLKDGSTMLIEA 704
Query: 120 AAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQ 179
A G+T V+ L+ ++ T L +H A R+ V L + + +
Sbjct: 705 AKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSH-DLNRAPRVPVQALPMVVPPQEPDK 763
Query: 180 TAFDVADE-DILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLII 238
+VA I QK + L + +D + + + ++Q E I
Sbjct: 764 PPANVATTLPIRNKAASKQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIK 823
Query: 239 EPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTK 288
E + ++++SLE D+ + K +E + + EE + + E K +
Sbjct: 824 EAIEKNAQLQSLELAHADQLTKEKIEELNKTREEQIQKKQKILEELQKVE 873
Score = 35.0 bits (79), Expect = 0.33
Identities = 31/131 (23%), Positives = 57/131 (43%), Gaps = 8/131 (6%)
Query: 533 EKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAG-----TVSSTTEVRERRRSYLTPVR 587
E +K A T+P+ + S++ L + T S + E + LT +
Sbjct: 760 EPDKPPANVATTLPIRNKAASKQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELE 819
Query: 588 DEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEK 647
E+ K Q+ + + Q +T ++E KT R + +++ EE +K E+E
Sbjct: 820 QRIKEAIEKNAQLQSLELAHADQ-LTKEKIEELNKT--REEQIQKKQKILEELQKVEREL 876
Query: 648 QDKEKQEEKKE 658
Q K +Q+ KK+
Sbjct: 877 QLKTQQQLKKQ 887
Score = 31.6 bits (70), Expect = 3.6
Identities = 19/56 (33%), Positives = 28/56 (50%), Gaps = 1/56 (1%)
Query: 2 VKFLVENGANINQPD-NEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPL 56
V+FL+ GAN+N+ N L A + G+L + E L+ GA +G T L
Sbjct: 646 VQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 701
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 88.2 bits (217), Expect = 3e-17
Identities = 142/562 (25%), Positives = 223/562 (39%), Gaps = 111/562 (19%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGA--VNSEGDTPLDI 58
+V L++ AN+ G PL AAS GY ++ L+ +GA V A V S DT L I
Sbjct: 1016 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1075
Query: 59 AEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHV 118
A ++ + + + R HI DVR+ K G T L +
Sbjct: 1076 AADKGHYKFCELLIGR-------------------------GAHI-DVRN-KKGNTPLWL 1108
Query: 119 AAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVG 178
AA G+ +V++LL+QAG DV+ D TPL AA G + R LV + VN+
Sbjct: 1109 AANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV------KEVNQF- 1161
Query: 179 QTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPL-IESTANMDNNQSQKTFKNKETLI 237
+D + + Y+ + K+ L KK L +ES + Q+ + KN L+
Sbjct: 1162 -----PSDSECMRYIATITDKEML-------KKCHLCMESIVQAKDRQAAEANKNASILL 1209
Query: 238 IEPEKNASRIES------LEQEKVDEEEEGKKDESSCSSEEDEEDDSES-EAETDKTKPL 290
E + R ES ++EK E+ KK+E EE E + E+ E + + K
Sbjct: 1210 EELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEK 1269
Query: 291 ASVTNANTSSTQAAPVAVTTPT--VSSGQATPTSPIKKFPTTATKISPKEEERKDE-SPA 347
V + T+ P A TT T +S+ T K T T S K + RK++ +P
Sbjct: 1270 LKVEDEPEVLTE-PPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPE 1328
Query: 348 TWRLGLRK--TGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLD---NKEKEKDS 402
++ SY ++ G+ + + + + + R+SS D N + S
Sbjct: 1329 NVQIIFDDPLPISYSQPEKV----NGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKS 1384
Query: 403 KGTRLAYVAPTI-PRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGST 461
A V T+ ++ S KE R S S + S +K + +++EG++
Sbjct: 1385 DNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKAS-----------IKLSETISEGTS 1433
Query: 462 YHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSS 521
S + S PS S+P K+T S G +
Sbjct: 1434 NSLS---------TCTKSGPSPLSSP------------------NGKLTVASPKRGQKRE 1466
Query: 522 TSNRLWAEDSTEKEKDSVPTAV 543
W E +K SVP+ V
Sbjct: 1467 EG---WKEVVRRSKKVSVPSTV 1485
Score = 69.3 bits (168), Expect = 2e-11
Identities = 65/221 (29%), Positives = 100/221 (45%), Gaps = 36/221 (16%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ + L+++GA +N P + PL AA G++++A LI +GA + VN EG TPL A
Sbjct: 449 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAA 508
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
E EE++ + QG +I A +E + TAL +A
Sbjct: 509 REGHEEMVALLLG-QGANINAQTEETQE-------------------------TALTLAC 542
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
G+ EV LI+AG D+ + TPL AA G E + L+ ++ G T
Sbjct: 543 CGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDT 599
Query: 181 AFDVADE----DILGYLEELQKKQNLLHSEKRDKKSPLIES 217
A A E D+ L LQ +L H E ++PL+++
Sbjct: 600 ALTYACENGHTDVADVL--LQAGADLEH-ESEGGRTPLMKA 637
Score = 64.7 bits (156), Expect = 4e-10
Identities = 54/192 (28%), Positives = 86/192 (44%), Gaps = 17/192 (8%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+VK L+ + A++N + G L A + GY+D+ + L+ GA + N G TPL A
Sbjct: 316 IVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAG 375
Query: 61 EEAMEELLQNEV-NRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGG------ 113
E+ + + N G++ + +E + L + GH+ VR G
Sbjct: 376 SAGHVEVARLLLENGAGINTHSNEFKESALTLACYK-----GHLEMVRFLLEAGADQEHK 430
Query: 114 -----TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNL 168
TAL A G+ EV +LL+ +G VN+ +PL AA G E +L++
Sbjct: 431 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 490
Query: 169 CDMEMVNKVGQT 180
+E VN G T
Sbjct: 491 ASLEEVNDEGYT 502
Score = 61.6 bits (148), Expect = 3e-09
Identities = 62/214 (28%), Positives = 95/214 (44%), Gaps = 43/214 (20%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEG-DTPLDIA 59
+V+ L+E GA+I D +G+ PL AA+ G++ + E L+ GA + A + DTPL +A
Sbjct: 847 LVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLA 906
Query: 60 ----EEEAMEELLQNEVNRQGVDIE-------AARKEEERIM--LRDARQWLNS------ 100
+E +E LL N++ ++ AA I+ L +A +NS
Sbjct: 907 CSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKL 966
Query: 101 -----------GHINDVRHAKSGG------------TALHVAAAKGYTEVLKLLIQAGYD 137
GH V+ G TAL +A +G TEV+ LL+ +
Sbjct: 967 GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKAN 1026
Query: 138 VNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDM 171
V + G TPL AA G E R+L+D D+
Sbjct: 1027 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1060
Score = 57.8 bits (138), Expect = 5e-08
Identities = 48/167 (28%), Positives = 76/167 (45%), Gaps = 31/167 (18%)
Query: 3 KFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD-TPLDIAEE 61
K L+E G ++N+ EG L A S GY ++A+ L+ A+V +GD TPL A
Sbjct: 252 KLLIE-GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAAN 310
Query: 62 EAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVR-HAKSGGTALHVAA 120
++++ L H DV + +G TAL A
Sbjct: 311 GGHVKIVK----------------------------LLLAHKADVNAQSSTGNTALTYAC 342
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 167
A GY +V+K+L+++G + + +G TPL A G E R+L++N
Sbjct: 343 AGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN 389
Score = 49.7 bits (117), Expect = 1e-05
Identities = 57/216 (26%), Positives = 100/216 (46%), Gaps = 27/216 (12%)
Query: 23 LHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEE----AMEELLQNEVNRQGVD 78
L A + G+ ++ + L+ +GA + + +G TPL +A +E LL N G D
Sbjct: 836 LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN-----GAD 890
Query: 79 IEAARKEEERIML--------RDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKL 130
IEA + + L ++ + L + N S T L +AA+ GY ++K+
Sbjct: 891 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 950
Query: 131 LIQAGYDVNIKDYD--GWTPLHAAAHWGKEEACRILVDNLCDME-MVNKVGQTAFDVA-- 185
L+ AG ++N + G +PL AA G A ++L+D D+ + TA +A
Sbjct: 951 LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACF 1010
Query: 186 --DEDILGYLEELQKKQNLLHSEKRDKKSPLIESTA 219
+++ L L +K N+ H K +PL+E+ +
Sbjct: 1011 QGRTEVVSLL--LDRKANVEHRAKTG-LTPLMEAAS 1043
Score = 43.5 bits (101), Expect = 0.001
Identities = 24/68 (35%), Positives = 38/68 (55%)
Query: 105 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 164
D + + TAL +A A G+ E+++ L++ G + +D G+TPL AA G IL
Sbjct: 825 DAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEIL 884
Query: 165 VDNLCDME 172
+DN D+E
Sbjct: 885 LDNGADIE 892
Score = 40.8 bits (94), Expect = 0.006
Identities = 55/268 (20%), Positives = 116/268 (43%), Gaps = 31/268 (11%)
Query: 582 YLTPVRDEES--------ESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTR 633
Y+ + D+E ES +A+ RQA ++ ++ + L+E + R S R
Sbjct: 1170 YIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASIL----LEELDLEKLREESRRLA 1225
Query: 634 EQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRP----VSTSS 689
EK KE++ K+ +E++ + +E E ++ ++ + ++ ++ P S+
Sbjct: 1226 LAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSA 1285
Query: 690 STTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQ 749
+TT + +S ++L A S R N++ +S ++N + E + D
Sbjct: 1286 TTTTTIGISATWTTL-AGSHGKRNNTITTTSS------KRKNRKNKITPENVQIIFDDPL 1338
Query: 750 PKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKET-QTDSISRYETSST 808
P S + + + +S+ S + D + S ++E SN + ++D+ S ++T
Sbjct: 1339 PISYSQPEKVNGESKSSSTS---ESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTT 1395
Query: 809 SAGDRYDSLLGRSGSYSYLEERKPYSSR 836
+ + S+L EERK S +
Sbjct: 1396 VSSKKQPSVLVTFPK----EERKSVSGK 1419
Score = 39.7 bits (91), Expect = 0.013
Identities = 46/181 (25%), Positives = 72/181 (39%), Gaps = 31/181 (17%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ + E+ AN Q DN L A S G ++ L+ +G V EG++ L +A
Sbjct: 219 LTRMRAESTANAGQSDNRS---LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLAC 275
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHIN-DVRHAKSGGTALHVA 119
EL Q L + H N + R K T L A
Sbjct: 276 SAGYYELAQV---------------------------LLAMHANVEDRGIKGDITPLMAA 308
Query: 120 AAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQ 179
A G+ +++KLL+ DVN + G T L A G + ++L+++ +E N+ G
Sbjct: 309 ANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGH 368
Query: 180 T 180
T
Sbjct: 369 T 369
Score = 37.4 bits (85), Expect = 0.066
Identities = 28/106 (26%), Positives = 49/106 (46%), Gaps = 12/106 (11%)
Query: 92 RDARQWLNSGHINDVR-----------HAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNI 140
R + + G +N VR H + G + L +A + GY E+ ++L+ +V
Sbjct: 236 RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 295
Query: 141 KDYDG-WTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 185
+ G TPL AAA+ G + ++L+ + D+ + G TA A
Sbjct: 296 RGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341
Score = 33.9 bits (76), Expect = 0.73
Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 1/56 (1%)
Query: 5 LVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGD-TPLDIA 59
L++ GA++ G PL AA G++ +FLI +GA+V + D T L +A
Sbjct: 616 LLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671
Score = 31.6 bits (70), Expect = 3.6
Identities = 19/56 (33%), Positives = 28/56 (50%), Gaps = 1/56 (1%)
Query: 2 VKFLVENGANINQPD-NEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPL 56
V+FL+ GAN+N+ N L A + G+L + E L+ GA +G T L
Sbjct: 646 VQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 701
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 87.8 bits (216), Expect = 4e-17
Identities = 188/914 (20%), Positives = 337/914 (36%), Gaps = 134/914 (14%)
Query: 111 SGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCD 170
+G TALH A +GY +V K L+ AG +VN K D TPLH AA+ G + ++L+ +
Sbjct: 200 AGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGN 259
Query: 171 MEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEK------RDKKSPLIESTANMDNN 224
+ N+ G+T VA+ + L L K SE+ ++ +P ++++D N
Sbjct: 260 PQQSNRKGETPLKVANSPTMVNL--LLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGN 317
Query: 225 QSQKTF-KNKETLIIEPEKNASRIESLEQEKVDEEEEGKK-----DESSCSSEEDEEDDS 278
+ F K + PE + ++ + DE++E + D+ + +E S
Sbjct: 318 NTDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKS 377
Query: 279 ESEAETDKTKPLASVTNANTSSTQAAPVAV---------TTPTVSSGQATPTSPIKKFPT 329
S K + + S T NT + + A + + TV +G+ S P
Sbjct: 378 NSFISIPKME-VKSYTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPG 436
Query: 330 TAT-----------KISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTA 378
+ T K K++ +K+ R G R + +E +S+ G+ ++D+
Sbjct: 437 SKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSL 496
Query: 379 GVTRS-------ASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRD 431
G + P L SSL S + ++ + ++ S +D K R
Sbjct: 497 GSSGCLKGSPLVLKDPSLFSSL--------SASSTSSHGSSAAQKQNPSHTDQHTKHWRT 548
Query: 432 SS------------SLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSS 479
+ S + S+ TR E D +EGS+ +RQ+ +S
Sbjct: 549 DNWKTISSPAWSEVSSLSDSTRTRLTSESDYS-----SEGSSVESLKPVRKRQEHRKRAS 603
Query: 480 VPSTTSTPTVTSAAGLQKSLLSSTSTTTKITT---GSSSAGTQSSTSNRLWAEDSTEKEK 536
+ S +P ++SA G L K T + Q S S L + T + +
Sbjct: 604 L-SEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYE 662
Query: 537 DSVPTAVTIPVAPTVVNAAASTTTL--------------------TTTTAGTVSSTTEVR 576
DS + + ++ L S ++
Sbjct: 663 DSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIK 722
Query: 577 ERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQE 636
+ + R+E+ S + + R ++ + + L + +K+ R +
Sbjct: 723 DTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDL 782
Query: 637 NEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKY--SRTYDETYQRYRPVSTSSSTTPS 694
E+K +EKEK KE +E+ K+ + RED +Y + E +S
Sbjct: 783 KEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWF 842
Query: 695 SSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSIR 754
S LS S + P +T + + + + K K R
Sbjct: 843 SDLSDSSFDFKGEDSWDSP-------------VTDYRDMKSDSVAKLILETVKEDSKERR 889
Query: 755 ERRRPREKRRSTGVSFWTQDS---DENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAG 811
R REKR F +D D+N ++++ TE+ + ++ + S+ +
Sbjct: 890 RDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGR 949
Query: 812 DRYDSLLG----RSG----SYSYLEERKP---YSSRLEKDDSTDFKKL--YEQILAENEK 858
DR D+L R G ++ EE K S +K D K L +E+ EK
Sbjct: 950 DRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREK 1009
Query: 859 LKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEELKMLP 918
K D K + ER+ ++S + +K E+ LE+ + E + K
Sbjct: 1010 EKKDGPDKE----------RKEKTKPERYKEKS-SDKDKSEKSILEKCQKDKEFD-KCFK 1057
Query: 919 DLKADNQRLKDENG 932
+ K ++ KD +G
Sbjct: 1058 EKKDTKEKHKDTHG 1071
Score = 61.2 bits (147), Expect = 4e-09
Identities = 75/361 (20%), Positives = 151/361 (41%), Gaps = 39/361 (10%)
Query: 574 EVRERRRSYLTPVRDEESESQRKARSRQAR-QSRRSTQGVTLTDLQEAEKTIGRSRSTRT 632
E E R +Y + + S+ Q R + + RR +G + EK + + +
Sbjct: 1151 EKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKD 1210
Query: 633 REQENEEKEKEEK-------EKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPV 685
+E + K+++++ +K++K+K EK E + + ED+ K K+ D+ + + R
Sbjct: 1211 KESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKS 1270
Query: 686 STSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREG-----EKREE 740
S S+ S +L+ R +S I+ S T + G E
Sbjct: 1271 SRSADAEKSLLEKLEEEALHE----YREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFT 1326
Query: 741 EKEGEDKSQ-----PKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKE- 794
E G+DK + P+ ++E+ R R S+ S + D + ++E+ E+G + KE
Sbjct: 1327 EPPGDDKPRESACLPEKLKEKER---HRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEG 1383
Query: 795 -TQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQIL 853
++ DS +YE A D Y SY+ + + + + ST+ K +
Sbjct: 1384 GSRKDS-GQYEKDFLEA-DAY------GVSYNMKADIEDELDKTIELFSTEKKDKNDSER 1435
Query: 854 AENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEE 913
++K++ +L ++ + +K + +E++ D E E+ R + + +E
Sbjct: 1436 EPSKKIEKELKPYGSSAINILKEKKKREKHREKWRD----EKERHRDRHADGLLRHHRDE 1491
Query: 914 L 914
L
Sbjct: 1492 L 1492
Score = 42.0 bits (97), Expect = 0.003
Identities = 60/363 (16%), Positives = 143/363 (39%), Gaps = 59/363 (16%)
Query: 582 YLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKE 641
Y+ + +ESE R + + ++ LQE E+ S R R+ +++
Sbjct: 1114 YIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHP 1173
Query: 642 KEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMS 701
+ +K+K+ +++++++ ++ R+ + ++ +++++ ST +
Sbjct: 1174 ERQKDKEPRDRRKDRGAADAGRDKK---------EKVFEKHKEKKDKESTEKYKDRKDRA 1224
Query: 702 SSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKE-GEDKSQPKSIRERRRPR 760
S S ++ N A + ++ + K + +KE +++ +S +
Sbjct: 1225 S---VDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLL 1281
Query: 761 EKRRSTGVSFWTQDSDENEQEQQSD-------------------TEEGSNKKETQTDSI- 800
EK + + +DS++ E SD TE + K ++ +
Sbjct: 1282 EKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLP 1341
Query: 801 ------SRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILA 854
R+ SS+S+ +D + E+ + Y + DS ++K
Sbjct: 1342 EKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEK------- 1394
Query: 855 ENEKLKAQLHDTNMEL-TDLKLQLEKATQRQERFADRSLLEMEKRERRALERRIS-EMEE 912
+ L+A + + + D++ +L+K + L EK+++ ER S ++E+
Sbjct: 1395 --DFLEADAYGVSYNMKADIEDELDKTIE---------LFSTEKKDKNDSEREPSKKIEK 1443
Query: 913 ELK 915
ELK
Sbjct: 1444 ELK 1446
Score = 38.9 bits (89), Expect = 0.023
Identities = 56/279 (20%), Positives = 109/279 (39%), Gaps = 45/279 (16%)
Query: 618 QEAEKTIG--RSRSTRTR----EQENEEKEKEEK---EKQDKEKQ-----EEKKESETSR 663
+E EK G + R +T+ ++++ +K+K EK EK K+K+ +EKK+++
Sbjct: 1007 REKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKH 1066
Query: 664 EDEYKQKYSR--TYDETYQRYRPV---------STSSSTTPSSSLSTMSSSLYASSQLNR 712
+D + + R + D+ ++ S S + ++ +
Sbjct: 1067 KDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDD 1126
Query: 713 PNSLVGITSAYSRGIT-----------KENEREGEKREEEKEGEDKSQPKSIRERRRPRE 761
+S +G S + G KE RE + ++ DK P+ ++ + PR+
Sbjct: 1127 RDSCMG--SGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKD-KEPRD 1183
Query: 762 KRRSTGVSFWTQDSDEN--EQEQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLG 819
+R+ G + +D E E+ ++ +E + K + + D S T + L
Sbjct: 1184 RRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQK----LP 1239
Query: 820 RSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEK 858
+ E K S EK D K+ A+ EK
Sbjct: 1240 EKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEK 1278
Score = 35.4 bits (80), Expect = 0.25
Identities = 56/264 (21%), Positives = 100/264 (37%), Gaps = 30/264 (11%)
Query: 204 HSEKRDKKSPLI----ESTANMDNNQSQKTFKNKETLIIEPEKNAS---RIESLEQEKVD 256
H EK+DK+S + A++D+ Q +K NK+ L + EK + + +S +EK D
Sbjct: 1205 HKEKKDKESTEKYKDRKDRASVDSTQDKK---NKQKLPEKAEKKHAAEDKAKSKHKEKSD 1261
Query: 257 EEEEGKKDESSCSSEEDE-----EDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTP 311
+E ++ S + E E+++ E D ++ V++ + + P
Sbjct: 1262 KEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFL 1321
Query: 312 TVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEG 371
VS + ++ K+ KE R S S + A KE
Sbjct: 1322 EVSFTEPPGDDKPRESACLPEKLKEKERHRHSSS-----------SSKKSHDRERAKKEK 1370
Query: 372 QKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRD 431
++K+ + S + S + E D+ G A I L T ++ E +D
Sbjct: 1371 AEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKA-DIEDELDKTIELFSTEKKD 1429
Query: 432 SSSLRTSSSYTRRKWEDDLKKNSS 455
+ S +K E +LK S
Sbjct: 1430 KNDSEREPS---KKIEKELKPYGS 1450
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 86.7 bits (213), Expect = 1e-16
Identities = 56/192 (29%), Positives = 93/192 (48%), Gaps = 8/192 (4%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+++ L+++GA+I G P+H AA G+++I L+ GA N G+T L +A
Sbjct: 415 VMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAA 474
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEE-------RIMLRDARQWLNSGHINDVRHAKSGG 113
E+++ V + G +EA K+++ R+ D Q L + SG
Sbjct: 475 RSGQAEVVRYLV-QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533
Query: 114 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 173
T LH++A +G+ +V L+ G ++I G+TPLH AA +GK E +L+ +
Sbjct: 534 TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA 593
Query: 174 VNKVGQTAFDVA 185
K G T VA
Sbjct: 594 AGKSGLTPLHVA 605
Score = 82.8 bits (203), Expect = 1e-15
Identities = 64/223 (28%), Positives = 105/223 (47%), Gaps = 37/223 (16%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+VK LV NGAN+N G+ PL+ AA +L++ +FL+ GA +G TPL +A
Sbjct: 122 VVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVAL 181
Query: 61 EEAMEE----LLQNE----VNRQGVDIEAARKEEER----IMLRDARQWLNS-------- 100
++ ++ LL+N+ V + I AARK++ + ++ D + S
Sbjct: 182 QQGHDQVVSLLLENDTKGKVRLPALHI-AARKDDTKAAALLLQNDNNADVESKSGFTPLH 240
Query: 101 -----GHINDVR-----------HAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYD 144
G+IN A++ T LHVA+ +G ++KLL+ G ++ K D
Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD 300
Query: 145 GWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADE 187
G TPLH A G E+ +L+D + K G + +A +
Sbjct: 301 GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQ 343
Score = 79.0 bits (193), Expect = 2e-14
Identities = 58/198 (29%), Positives = 91/198 (45%), Gaps = 14/198 (7%)
Query: 5 LVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAM 64
L++ GA+ + G+ PLH AA +DIA L+ GA AV +G + +A +E
Sbjct: 617 LLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGH 676
Query: 65 EELLQ---------NEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTA 115
+++ N N+ G+ +E+R+ + A +N G D + K G T
Sbjct: 677 VDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNV--AEVLVNQGAHVDAQ-TKMGYTP 733
Query: 116 LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVN 175
LHV G +++ L+Q VN K +G+TPLH AA G +L+ N +
Sbjct: 734 LHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELT 793
Query: 176 KVGQTAFDVADEDILGYL 193
G TA +A LGY+
Sbjct: 794 VNGNTALGIARR--LGYI 809
Score = 75.5 bits (184), Expect = 2e-13
Identities = 54/185 (29%), Positives = 79/185 (42%), Gaps = 27/185 (14%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+V++LV++GA + + PLH +A G DI + L+ QGA A + G TPL ++
Sbjct: 481 VVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSA 540
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
E E++ A L+ G + K G T LHVAA
Sbjct: 541 REGHEDV--------------------------AAFLLDHGASLSIT-TKKGFTPLHVAA 573
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
G EV LL+Q + G TPLH AAH+ ++ +L+D K G T
Sbjct: 574 KYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYT 633
Query: 181 AFDVA 185
+A
Sbjct: 634 PLHIA 638
Score = 69.3 bits (168), Expect = 2e-11
Identities = 49/190 (25%), Positives = 92/190 (48%), Gaps = 4/190 (2%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+V L++ AN++ +G LH A+ G ++ + L+ GA+V A + G TPL +A
Sbjct: 89 VVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA 148
Query: 61 EEAMEELLQNEVNRQGVDIEAARKE---EERIMLRDARQWLNSGHINDVRHAKSGGTALH 117
+E E+++ ++ G A ++ + L+ + S + + K ALH
Sbjct: 149 QENHLEVVKFLLD-NGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALH 207
Query: 118 VAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKV 177
+AA K T+ LL+Q + +++ G+TPLH AAH+G +L++ ++ +
Sbjct: 208 IAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN 267
Query: 178 GQTAFDVADE 187
T VA +
Sbjct: 268 DITPLHVASK 277
Score = 68.6 bits (166), Expect = 3e-11
Identities = 58/224 (25%), Positives = 99/224 (44%), Gaps = 13/224 (5%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MVK L++ GA I+ +G PLH A G+ + E L+ + A + + G +PL +A
Sbjct: 283 MVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMAT 342
Query: 61 E----EAMEELLQNEVNRQGV--DIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGT 114
+ ++ LLQ+ V V D A + L N A +G T
Sbjct: 343 QGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFT 402
Query: 115 ALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMV 174
LH+A K +V++LL++ G + G TP+H AA G L+ +
Sbjct: 403 PLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTT 462
Query: 175 NKVGQTAFDVA----DEDILGYLEELQKKQNLLHSEKRDKKSPL 214
N G+TA +A +++ YL + + + ++ +D ++PL
Sbjct: 463 NVRGETALHMAARSGQAEVVRYLVQDGAQ---VEAKAKDDQTPL 503
Score = 67.4 bits (163), Expect = 6e-11
Identities = 52/189 (27%), Positives = 80/189 (42%), Gaps = 12/189 (6%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ L++ A+ + G PLH AA +A L+ QGA A G TPL IA
Sbjct: 580 VANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639
Query: 61 EEAMEELL---------QNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKS 111
++ ++ N V RQG+ +E + D L + N KS
Sbjct: 640 KKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHV---DMVSLLLGRNANVNLSNKS 696
Query: 112 GGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDM 171
G T LH+AA + V ++L+ G V+ + G+TPLH H+G + L+ + +
Sbjct: 697 GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKV 756
Query: 172 EMVNKVGQT 180
K G T
Sbjct: 757 NAKTKNGYT 765
Score = 64.3 bits (155), Expect = 5e-10
Identities = 49/164 (29%), Positives = 72/164 (43%), Gaps = 35/164 (21%)
Query: 26 AASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEA----MEELLQNEVNRQGVDIEA 81
AA G+L+ A I G + N G L +A +E + ELLQ E N ++A
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN-----VDA 102
Query: 82 ARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIK 141
A K+ G TALH+A+ G EV+K+L+ G +VN +
Sbjct: 103 ATKK--------------------------GNTALHIASLAGQAEVVKVLVTNGANVNAQ 136
Query: 142 DYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 185
+G+TPL+ AA E + L+DN + + G T VA
Sbjct: 137 SQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180
Score = 60.8 bits (146), Expect = 6e-09
Identities = 41/162 (25%), Positives = 77/162 (47%), Gaps = 27/162 (16%)
Query: 6 VENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAME 65
++NG +IN + G LH A+ G++++ L+ + A+V A +G+T L IA
Sbjct: 61 IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQA 120
Query: 66 ELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYT 125
E+++ V N ++N +++G T L++AA + +
Sbjct: 121 EVVKVLVT-------------------------NGANVN--AQSQNGFTPLYMAAQENHL 153
Query: 126 EVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 167
EV+K L+ G ++ DG+TPL A G ++ +L++N
Sbjct: 154 EVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195
Score = 59.3 bits (142), Expect = 2e-08
Identities = 57/217 (26%), Positives = 89/217 (41%), Gaps = 42/217 (19%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDI-- 58
MV L+ AN+N + G PLH AA +++AE L+ QGAHV A G TPL +
Sbjct: 679 MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGC 738
Query: 59 --AEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTAL 116
+ + LLQ +S +N K+G T L
Sbjct: 739 HYGNIKIVNFLLQ-----------------------------HSAKVN--AKTKNGYTPL 767
Query: 117 HVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNK 176
H AA +G+T ++ +L+Q N +G T L A G +VD L ++V +
Sbjct: 768 HQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYIS----VVDTL---KIVTE 820
Query: 177 VGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSP 213
T V ++ + E + + ++ E R +P
Sbjct: 821 ETMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAP 857
Score = 41.6 bits (96), Expect = 0.004
Identities = 24/79 (30%), Positives = 45/79 (56%)
Query: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
++G ALH+A+ +G+ EV+ L+Q +V+ G T LH A+ G+ E ++LV N
Sbjct: 72 QNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGA 131
Query: 170 DMEMVNKVGQTAFDVADED 188
++ ++ G T +A ++
Sbjct: 132 NVNAQSQNGFTPLYMAAQE 150
Score = 41.2 bits (95), Expect = 0.005
Identities = 48/220 (21%), Positives = 85/220 (38%), Gaps = 34/220 (15%)
Query: 476 ISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDS---- 531
I ++ P T P S K S S TK T SS +S + D+
Sbjct: 3867 IKATSPKDTFPPNHMSNTKASKMKQVSQSEKTKALTTSSCVDVKSRIPVKNTHRDNIIAV 3926
Query: 532 -----TEKEKD-------SVPTAVTIPVAPTVVNAAAST--TTLTTTTAGTVSSTTEVRE 577
T+K+ +P+ + + V T V +T TT TTTT T S T +VR+
Sbjct: 3927 RKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVTTTTTTATTTTTTTTTTTTSCTVKVRK 3986
Query: 578 RRRSYL---------------TPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEK 622
+ + + D SE ++K +S + + +++ +L++ +
Sbjct: 3987 SQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSLSETSRGGQ 4046
Query: 623 TIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETS 662
++S R ++ E K + EK EK+ ++ S
Sbjct: 4047 PSVTTKSARDKKTE-AAPLKSKSEKAGSEKRSSRRTGPQS 4085
Score = 37.4 bits (85), Expect = 0.066
Identities = 101/544 (18%), Positives = 195/544 (35%), Gaps = 101/544 (18%)
Query: 269 SSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFP 328
S+ +++ +S++ D+TKP + +T TPT ++TPTS FP
Sbjct: 3546 SNNRGDDEVFDSKSREDETKPFGLAVEDRSPATTPDTTPARTPT---DESTPTSEPNPFP 3602
Query: 329 ---------TTATKISPKEEERKDESPATWRLGLR----KTGSYGA--LAEITASKEGQK 373
T + I + + +E +++G K+G G + +TA+ + Q
Sbjct: 3603 FHEGKMFEMTRSGAIDMSKRDFVEERLQFFQIGEHTSEGKSGDQGEGDKSMVTATPQPQS 3662
Query: 374 EKDT--AGVTRSASSPRL-------------SSSLDNKEKEKDSKGTRLAYVAPTIPRRL 418
T + R+ +P + + + EK + T + V P + +
Sbjct: 3663 GDTTVETNLERNVETPTVEPNPSIPTSGECQEGTSSSGSLEKSAAATNTSKVDPKLRTPI 3722
Query: 419 -----ASTSDIEEK---ENRDS-SSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFG 469
AST ++++ E D ++ TS + + ++ G H+ F
Sbjct: 3723 KMGISASTMTMKKEGPGEITDKIEAVMTSCQGLENETITMISNTANSQMGVRPHEKHDFQ 3782
Query: 470 R----RQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQS---ST 522
+ ++L SS++ + + + + K+++G + Q
Sbjct: 3783 KDNFNNNNNLDSSTIQTDNIMSNIVLTEHSAPTCTTEKDNPVKVSSGKKTGVLQGHCVRD 3842
Query: 523 SNRLWAEDSTEKEKDSVPTAVTIPVAPT--------------------VVNAAASTTTLT 562
++ E KE + +P+ T V+ + T LT
Sbjct: 3843 KQKVLGEQQKTKELIGIRQKSKLPIKATSPKDTFPPNHMSNTKASKMKQVSQSEKTKALT 3902
Query: 563 TTTAGTVSSTTEVRERRRSYLTPVR----DEESESQRKARSRQ--------ARQSRRSTQ 610
T++ V S V+ R + VR ++ K +++Q R + +T
Sbjct: 3903 TSSCVDVKSRIPVKNTHRDNIIAVRKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVTTT 3962
Query: 611 GVTLTDLQEAEKTIGRSRSTRTREQENEEKEK-----------EEKEKQDKEKQEEKK-E 658
T T T S + + R+ + +E K E + D+ +EEKK +
Sbjct: 3963 TTTATTTTTTTTTTTTSCTVKVRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQ 4022
Query: 659 SETSREDEYKQKYSRTYDETYQRYRPVSTSSS-------TTPSSSLSTMSSSLYASSQLN 711
SE S E+E + + + ET + +P T+ S P S S + S SS+
Sbjct: 4023 SELSDEEESTSR-NTSLSETSRGGQPSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRT 4081
Query: 712 RPNS 715
P S
Sbjct: 4082 GPQS 4085
Score = 33.1 bits (74), Expect = 1.3
Identities = 49/243 (20%), Positives = 96/243 (39%), Gaps = 40/243 (16%)
Query: 631 RTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQR----YRPVS 686
+ +E ++E+KEK + + Q+E + + + +++E+ +E Q
Sbjct: 3335 KLKEVDDEQKEKPKASAEKASNQKELESNGSGKDNEFGLGLDSPQNEIAQNGNNDQSITE 3394
Query: 687 TSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSR----------------GITKE 730
S +TT S T ++ + + + + G+T + S+ GI K
Sbjct: 3395 CSIATTAEFSHDTDATEIDSLDGYDLQDEDDGLTESDSKLPIQAMEIKKDIWNTEGILKP 3454
Query: 731 NEREGEK------REEEKEGEDKSQP--KSIRERRRPREKRRSTGVSFWTQDSDENEQEQ 782
+R + EE K G D+ +P KS + P + + +G F+T + ++
Sbjct: 3455 ADRSFSQSKLEVIEEEGKVGPDEDKPPSKSSSSEKTPDKTDQKSGAQFFTLEGRHPDRSV 3514
Query: 783 QSDT-------EEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSS 835
DT EE + +T ++ S + GD D + S S +E KP+
Sbjct: 3515 FPDTYFSYKVDEEFATPFKTVATKGLDFDPWSNNRGD--DEVF---DSKSREDETKPFGL 3569
Query: 836 RLE 838
+E
Sbjct: 3570 AVE 3572
Score = 32.0 bits (71), Expect = 2.8
Identities = 129/647 (19%), Positives = 224/647 (34%), Gaps = 78/647 (12%)
Query: 287 TKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESP 346
T+P S T A + A T+ + SS SP+K + +T SP
Sbjct: 1500 TRPYQSWTTAPITVPGPAKSGFTSLSSSSSNTPSASPLKSIWSVST-----------PSP 1548
Query: 347 ATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGT- 405
LG T S +++++ + R+ SSP + + + S GT
Sbjct: 1549 IKSTLGASTTSSVKSISDVASPIRS---------FRTMSSPIKTVVSQSPYNIQVSSGTL 1599
Query: 406 -RLAYVAPTIP-RRLASTSDIEEKEN--RDSSSLRTSSSYTRRKWEDDLKKNSSVNEGST 461
R V P + LAS S + + + SL SS T S++N S+
Sbjct: 1600 ARAPAVTEATPLKGLASNSTFSSRTSPVTTAGSLLERSSIT---MTPPASPKSNINMYSS 1656
Query: 462 YHKSCSFGRRQDDLISSSVPSTTS--TPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQ 519
S LISS + S S V + + ++ SS S+ K G +
Sbjct: 1657 SLPFKSIITSAAPLISSPLKSVVSPVKSAVDVISSAKITMASSLSSPVKQMPGHAEVALV 1716
Query: 520 SSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVR--E 577
+ + + L S+ TA + N+ +S + T T V STT
Sbjct: 1717 NGSISPLKYPSSSTLINGCKATATLQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFS 1776
Query: 578 RRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQEN 637
RSY++ +S R + S S+ T + + + T+ +
Sbjct: 1777 PLRSYVS-AAPSAFQSLRTPSASALYTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPA 1835
Query: 638 EEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSL 697
+K + + E + +SRT PV +S PS+
Sbjct: 1836 LKKLPDSNSFTKSAAALLSPIKTLTTETHPQPHFSRTSS-------PVKSSLFLAPSALK 1888
Query: 698 STMSSSLYASSQL-----NRPNSLVGITSAYSRGITKENEREGEKREEEKEGE-DKSQPK 751
+ SSL +S ++ L+ +T+ + +E + E KEG D +P
Sbjct: 1889 LSTPSSLSSSQEILKDVAEMKEDLMRMTAILQTDVPEEKPFQPEL---PKEGRIDDEEPF 1945
Query: 752 SIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAG 811
I E + +E +N+ +S + + E S E
Sbjct: 1946 KIVE--KVKEDLVKVSEILKKDVCVDNKGSPKSPKSDKGHSPEDDWIEFSSEEIREA--- 2000
Query: 812 DRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELT 871
R + +S S L ER ++ + + K+ + + + + LT
Sbjct: 2001 -RQQAAASQSPS---LPERVQVKAKAASEKDYNLTKVIDYLTND---------IGSSSLT 2047
Query: 872 DLKLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEELKMLP 918
+LK + E A + + E+R++R L+ I+ E +LKM P
Sbjct: 2048 NLKYKFEDAKK-----------DGEERQKRVLKPAIALQEHKLKMPP 2083
Score = 31.2 bits (69), Expect = 4.8
Identities = 22/74 (29%), Positives = 36/74 (48%), Gaps = 6/74 (8%)
Query: 259 EEGKKDESSCSSEEDEEDDSESEAETDKT-KPLASVTNANTSSTQAAPVAVTTPTV---- 313
EE KK +S S EE+ + S +ET + +P + +A T+AAP+ +
Sbjct: 4016 EEEKKMQSELSDEEESTSRNTSLSETSRGGQPSVTTKSARDKKTEAAPLKSKSEKAGSEK 4075
Query: 314 -SSGQATPTSPIKK 326
SS + P SP ++
Sbjct: 4076 RSSRRTGPQSPCER 4089
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 85.9 bits (211), Expect = 2e-16
Identities = 67/217 (30%), Positives = 104/217 (47%), Gaps = 31/217 (14%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ + LV +GA++N D + PLH AA+ G +I + L+ GA N +G+TPLD+ +
Sbjct: 732 VAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVK 791
Query: 61 EEAMEELLQNEVNRQGVDIEAARK----------EEERIMLRDARQ------WLNSGHIN 104
E + +Q+ + ++AA+K E I RD + L +G+ N
Sbjct: 792 EGDTD--IQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNN 849
Query: 105 ------------DVRHAKSGGTA-LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHA 151
DV GG LH AA+ G+ ++ LLI+ VN D +TPLH
Sbjct: 850 LEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHE 909
Query: 152 AAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADED 188
AA G+ + C +L+ + D M N+ GQT D+A D
Sbjct: 910 AAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD 946
Score = 81.6 bits (200), Expect = 3e-15
Identities = 71/215 (33%), Positives = 107/215 (49%), Gaps = 33/215 (15%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+V L+ GA+ N DN + PLH AA G +D+ L+ GA N++G + LD+A+
Sbjct: 264 VVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLAD 323
Query: 61 EEAMEELLQNEVNRQGVDIEAARK-EEERIML-----------RDARQ----WLNSGHIN 104
A + +L E + + +EAAR EE++M D R+ L +G+ N
Sbjct: 324 PSA-KAVLTGEYKKDEL-LEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGY-N 380
Query: 105 DVR------------HAKSGG--TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLH 150
VR HAK G LH A + G+ EV +LL++ G VN D +TPLH
Sbjct: 381 RVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLH 440
Query: 151 AAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 185
AA + E C +L+ + D +VN G++A D+A
Sbjct: 441 EAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
Score = 73.9 bits (180), Expect = 6e-13
Identities = 56/184 (30%), Positives = 93/184 (50%), Gaps = 9/184 (4%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ + L+++GA +N D + PLH AAS +++ L+ GA VN G + +D+A
Sbjct: 417 VTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAP 476
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
+ E L E + ++AAR+ + L ++ L IN + +S TALH A
Sbjct: 477 TPELRERLTYEFKGHSL-LQAAREAD----LAKVKKTLALEIIN-FKQPQSHETALHCAV 530
Query: 121 AKGY---TEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKV 177
A + +V +LL++ G +VN K+ D TPLH AA + +L + M ++ +
Sbjct: 531 ASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTL 590
Query: 178 GQTA 181
GQTA
Sbjct: 591 GQTA 594
Score = 71.6 bits (174), Expect = 3e-12
Identities = 66/274 (24%), Positives = 110/274 (40%), Gaps = 66/274 (24%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ + L+ GAN+N+ + + PLH AA + D+ E L GA + A+++ G T L A
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599
Query: 61 --------------------------------EEAMEELLQNEVNRQGVDIEAARKEEER 88
EA++++L + D++ E +
Sbjct: 600 LAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASK 659
Query: 89 I-MLRDARQWLNSGHIN----DVRHA-----------------------------KSGGT 114
L +Q +S ++N + RH+ K G
Sbjct: 660 AGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLV 719
Query: 115 ALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMV 174
LH A + G+ EV +LL++ G VN+ D +TPLH AA GK E C++L+ + D
Sbjct: 720 PLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKK 779
Query: 175 NKVGQTAFDVADEDILGYLEELQKKQNLLHSEKR 208
N+ G T D+ E + L+ LL + K+
Sbjct: 780 NRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKK 813
Score = 63.2 bits (152), Expect = 1e-09
Identities = 44/145 (30%), Positives = 67/145 (46%), Gaps = 2/145 (1%)
Query: 108 HAKSGG--TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILV 165
HA+ G LH A + G+ EV+ LL+ G D N +D +TPLH AA GK + C +L+
Sbjct: 243 HARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 302
Query: 166 DNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQ 225
+ D + N G++A D+AD L KK LL + + + L+ ++ N
Sbjct: 303 QHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNC 362
Query: 226 SQKTFKNKETLIIEPEKNASRIESL 250
+ L + N RI L
Sbjct: 363 HASDGRKSTPLHLAAGYNRVRIVQL 387
Score = 47.8 bits (112), Expect = 5e-05
Identities = 32/101 (31%), Positives = 44/101 (43%), Gaps = 33/101 (32%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAV------------ 48
+ ++L+E+GA++N D G IPLH AAS G++DIA LI V A
Sbjct: 852 VAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAA 911
Query: 49 ---------------------NSEGDTPLDIAEEEAMEELL 68
N EG TPLD+A + + LL
Sbjct: 912 QKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALL 952
Score = 47.0 bits (110), Expect = 8e-05
Identities = 52/153 (33%), Positives = 68/153 (44%), Gaps = 30/153 (19%)
Query: 2 VKFLVENGANINQPDNEGW--IPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIA 59
VK LV+ AN+N D G PLH AA G D+ E L+ GA+V A + G PL A
Sbjct: 198 VKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNA 256
Query: 60 EEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVA 119
E++ + + QG D A RD W T LH A
Sbjct: 257 CSFGHAEVV-SLLLCQGADPNA----------RD--NW--------------NYTPLHEA 289
Query: 120 AAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAA 152
A KG +V +L+Q G D NI++ DG + L A
Sbjct: 290 AIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA 322
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 85.5 bits (210), Expect = 2e-16
Identities = 64/200 (32%), Positives = 98/200 (49%), Gaps = 20/200 (10%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIA- 59
+VK LV+ GANIN G+ PL+ AA ++D+ ++L+ GA+ +G TPL +A
Sbjct: 91 VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVAL 150
Query: 60 ---EEEAMEELLQNE----VNRQGVDIEAARKEEERIMLRDARQWLNSGHINDV------ 106
+A+ LL+N+ V + I AARK++ + A L + H DV
Sbjct: 151 QQGHNQAVAILLENDTKGKVRLPALHI-AARKDD----TKSAALLLQNDHNADVQSKMMV 205
Query: 107 -RHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILV 165
R +SG T LH+AA G V LL+ G V+ +G TPLH A+ G ++L+
Sbjct: 206 NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLL 265
Query: 166 DNLCDMEMVNKVGQTAFDVA 185
D ++ + G T A
Sbjct: 266 DRGGQIDAKTRDGLTPLHCA 285
Score = 80.5 bits (197), Expect = 7e-15
Identities = 57/199 (28%), Positives = 93/199 (46%), Gaps = 16/199 (8%)
Query: 5 LVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAM 64
L+E GA+ + G+ PLH AA + IA L+ GA V +G TPL +A +E
Sbjct: 594 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 653
Query: 65 EELLQNEVNRQGVDIEAARK----------EEERIMLRDARQWLNSGHINDVRHAKSGGT 114
+++ +++ G +I + K +E+++ + D L + H K G T
Sbjct: 654 TDMVTLLLDK-GANIHMSTKSGLTSLHLAAQEDKVNVADI---LTKHGADQDAHTKLGYT 709
Query: 115 ALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMV 174
L VA G +++ L++ G +VN K +G+TPLH AA G +L+ +
Sbjct: 710 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNAT 769
Query: 175 NKVGQTAFDVADEDILGYL 193
G TA +A LGY+
Sbjct: 770 TANGNTALAIAKR--LGYI 786
Score = 80.1 bits (196), Expect = 9e-15
Identities = 66/230 (28%), Positives = 110/230 (47%), Gaps = 25/230 (10%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MVK L++ G I+ +G PLH AA G+ + E L+ +GA + A G +PL +A
Sbjct: 260 MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAA 319
Query: 61 E----EAMEELLQNEVNRQGVDIE-------AARKEEERI--MLRDARQWLNSGHINDVR 107
+ E ++ LLQ++ V ++ AA R+ +L D R N+ +N
Sbjct: 320 QGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN--- 376
Query: 108 HAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 167
G T LH+A K +V++LL++ G + G TP+H AA G +L+ N
Sbjct: 377 ----GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 432
Query: 168 LCDMEMVNKVGQTAFDVADEDILGYLEE---LQKKQNLLHSEKRDKKSPL 214
++ N G+TA +A G +E L + L+ + R++++PL
Sbjct: 433 GASPDVTNIRGETALHMAAR--AGQVEVVRCLLRNGALVDARAREEQTPL 480
Score = 72.0 bits (175), Expect = 2e-12
Identities = 54/189 (28%), Positives = 90/189 (47%), Gaps = 10/189 (5%)
Query: 5 LVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAM 64
L+E GA + +G+ PLH AA G LD+A+ L+ + A + G TPL +A
Sbjct: 528 LLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDN 587
Query: 65 EELLQNEVNRQGVDIEAARKE--------EERIMLRDARQWLNSGHINDVRHAKSGGTAL 116
+++ + + G A K ++ ++ A LN G ++ K G T L
Sbjct: 588 QKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIV-TKQGVTPL 645
Query: 117 HVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNK 176
H+A+ +G+T+++ LL+ G ++++ G T LH AA K IL + D + K
Sbjct: 646 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 705
Query: 177 VGQTAFDVA 185
+G T VA
Sbjct: 706 LGYTPLIVA 714
Score = 71.6 bits (174), Expect = 3e-12
Identities = 56/196 (28%), Positives = 92/196 (46%), Gaps = 16/196 (8%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIA- 59
+ K L++ AN N G+ PLH A + + E L+ GA + A+ G TP+ +A
Sbjct: 359 VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA 418
Query: 60 ---EEEAMEELLQNEVNRQGVDIE-------AARKEEERIMLRDARQWLNSGHINDVRHA 109
+ LLQN + +I AAR + ++ R L +G + D R A
Sbjct: 419 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV----RCLLRNGALVDAR-A 473
Query: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
+ T LH+A+ G TE+++LL+Q + +G+TPLH +A G+ + +L++
Sbjct: 474 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 533
Query: 170 DMEMVNKVGQTAFDVA 185
+ K G T VA
Sbjct: 534 AHSLATKKGFTPLHVA 549
Score = 71.6 bits (174), Expect = 3e-12
Identities = 54/199 (27%), Positives = 92/199 (46%), Gaps = 16/199 (8%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+V+ L+++ A+ + G+ PLH +A G +D+A L+ GA +G TPL +A
Sbjct: 491 IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAA 550
Query: 61 E----EAMEELLQNEVNRQGVDIE-------AARKEEERIMLRDARQWLNSGHINDVRHA 109
+ + + LLQ AA + +++ L + S H A
Sbjct: 551 KYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA-SPHAT----A 605
Query: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
K+G T LH+AA K ++ L+ G + NI G TPLH A+ G + +L+D
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
Query: 170 DMEMVNKVGQTAFDVADED 188
++ M K G T+ +A ++
Sbjct: 666 NIHMSTKSGLTSLHLAAQE 684
Score = 67.4 bits (163), Expect = 6e-11
Identities = 59/237 (24%), Positives = 108/237 (45%), Gaps = 35/237 (14%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+V+ L+ G++++ +G LH A+ G ++ + L+ +GA++ A + G TPL +A
Sbjct: 58 LVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 117
Query: 61 EE----AMEELLQNEVNRQ----------GVDIEAARKEEERIMLRDARQWLNSGHINDV 106
+E ++ LL+N N+ V ++ + I+L ND
Sbjct: 118 QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----------NDT 166
Query: 107 RHAKSGGTALHVAAAKGYTEVLKLLIQAGYD--------VNIKDYDGWTPLHAAAHWGKE 158
+ K ALH+AA K T+ LL+Q ++ VN G+TPLH AAH+G
Sbjct: 167 K-GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 225
Query: 159 EACRILVDNLCDMEMVNKVGQTAFDVADE-DILGYLEELQKKQNLLHSEKRDKKSPL 214
+L++ ++ + G T VA + ++ L + + ++ RD +PL
Sbjct: 226 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 282
Score = 65.1 bits (157), Expect = 3e-10
Identities = 52/192 (27%), Positives = 94/192 (48%), Gaps = 10/192 (5%)
Query: 2 VKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEE 61
VK L+++ A ++ + LH AA CG+ + + L+ + A+ A G TPL IA +
Sbjct: 327 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACK 386
Query: 62 EAMEELLQNEVNRQGVDIEAARKEEERIM--------LRDARQWLNSGHINDVRHAKSGG 113
+ ++++ V + G I+A + + L L +G DV + + G
Sbjct: 387 KNRIKVMELLV-KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR-GE 444
Query: 114 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 173
TALH+AA G EV++ L++ G V+ + + TPLH A+ GK E ++L+ ++ +
Sbjct: 445 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 504
Query: 174 VNKVGQTAFDVA 185
G T ++
Sbjct: 505 ATTNGYTPLHIS 516
Score = 64.3 bits (155), Expect = 5e-10
Identities = 50/192 (26%), Positives = 83/192 (43%), Gaps = 16/192 (8%)
Query: 5 LVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAM 64
L+ GA ++ G PLH A+ G ++ + L+ +G + A +G TPL A
Sbjct: 231 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 290
Query: 65 EELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGG----------- 113
+++++ + R G + A K L H+ V+H
Sbjct: 291 DQVVELLLER-GAPLLARTKNG----LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL 345
Query: 114 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 173
TALHVAA G+ V KLL+ + N + +G+TPLH A + + +LV ++
Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 405
Query: 174 VNKVGQTAFDVA 185
+ + G T VA
Sbjct: 406 ITESGLTPIHVA 417
Score = 63.2 bits (152), Expect = 1e-09
Identities = 43/162 (26%), Positives = 80/162 (49%), Gaps = 27/162 (16%)
Query: 6 VENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAME 65
++ G +IN + G LH AA G++ + + L+G+G+ V + +G+T L IA
Sbjct: 30 LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 89
Query: 66 ELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYT 125
E+++ V ++G +I A +++G T L++AA + +
Sbjct: 90 EVVKVLV-KEGANINA--------------------------QSQNGFTPLYMAAQENHI 122
Query: 126 EVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 167
+V+K L++ G + + DG+TPL A G +A IL++N
Sbjct: 123 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 164
Score = 59.7 bits (143), Expect = 1e-08
Identities = 55/208 (26%), Positives = 92/208 (44%), Gaps = 45/208 (21%)
Query: 26 AASCGYLD-IAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARK 84
AA G LD + E+L G G + N G L +A +E L+Q + R G +++A K
Sbjct: 17 AARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR-GSSVDSATK 74
Query: 85 EEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYD 144
+ G TALH+A+ G EV+K+L++ G ++N + +
Sbjct: 75 K--------------------------GNTALHIASLAGQAEVVKVLVKEGANINAQSQN 108
Query: 145 GWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQN--- 201
G+TPL+ AA + + L++N + + G T VA LQ+ N
Sbjct: 109 GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA----------LQQGHNQAV 158
Query: 202 --LLHSEKRDK-KSPLIESTANMDNNQS 226
LL ++ + K + P + A D+ +S
Sbjct: 159 AILLENDTKGKVRLPALHIAARKDDTKS 186
Score = 54.3 bits (129), Expect = 5e-07
Identities = 44/156 (28%), Positives = 67/156 (42%), Gaps = 27/156 (17%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MV L++ GANI+ G LH AA +++A+ L GA A G TPL +A
Sbjct: 656 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVAC 715
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
+++ N + +QG ++ A K+G T LH AA
Sbjct: 716 HYGNVKMV-NFLLKQGANVNA--------------------------KTKNGYTPLHQAA 748
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWG 156
+G+T ++ +L+Q G N +G T L A G
Sbjct: 749 QQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 784
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 85.5 bits (210), Expect = 2e-16
Identities = 64/200 (32%), Positives = 98/200 (49%), Gaps = 20/200 (10%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIA- 59
+VK LV+ GANIN G+ PL+ AA ++D+ ++L+ GA+ +G TPL +A
Sbjct: 112 VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVAL 171
Query: 60 ---EEEAMEELLQNE----VNRQGVDIEAARKEEERIMLRDARQWLNSGHINDV------ 106
+A+ LL+N+ V + I AARK++ + A L + H DV
Sbjct: 172 QQGHNQAVAILLENDTKGKVRLPALHI-AARKDD----TKSAALLLQNDHNADVQSKMMV 226
Query: 107 -RHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILV 165
R +SG T LH+AA G V LL+ G V+ +G TPLH A+ G ++L+
Sbjct: 227 NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLL 286
Query: 166 DNLCDMEMVNKVGQTAFDVA 185
D ++ + G T A
Sbjct: 287 DRGGQIDAKTRDGLTPLHCA 306
Score = 80.5 bits (197), Expect = 7e-15
Identities = 57/199 (28%), Positives = 93/199 (46%), Gaps = 16/199 (8%)
Query: 5 LVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAM 64
L+E GA+ + G+ PLH AA + IA L+ GA V +G TPL +A +E
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 674
Query: 65 EELLQNEVNRQGVDIEAARK----------EEERIMLRDARQWLNSGHINDVRHAKSGGT 114
+++ +++ G +I + K +E+++ + D L + H K G T
Sbjct: 675 TDMVTLLLDK-GANIHMSTKSGLTSLHLAAQEDKVNVADI---LTKHGADQDAHTKLGYT 730
Query: 115 ALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMV 174
L VA G +++ L++ G +VN K +G+TPLH AA G +L+ +
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNAT 790
Query: 175 NKVGQTAFDVADEDILGYL 193
G TA +A LGY+
Sbjct: 791 TANGNTALAIAKR--LGYI 807
Score = 80.1 bits (196), Expect = 9e-15
Identities = 66/230 (28%), Positives = 110/230 (47%), Gaps = 25/230 (10%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MVK L++ G I+ +G PLH AA G+ + E L+ +GA + A G +PL +A
Sbjct: 281 MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAA 340
Query: 61 E----EAMEELLQNEVNRQGVDIE-------AARKEEERI--MLRDARQWLNSGHINDVR 107
+ E ++ LLQ++ V ++ AA R+ +L D R N+ +N
Sbjct: 341 QGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN--- 397
Query: 108 HAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 167
G T LH+A K +V++LL++ G + G TP+H AA G +L+ N
Sbjct: 398 ----GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 453
Query: 168 LCDMEMVNKVGQTAFDVADEDILGYLEE---LQKKQNLLHSEKRDKKSPL 214
++ N G+TA +A G +E L + L+ + R++++PL
Sbjct: 454 GASPDVTNIRGETALHMAAR--AGQVEVVRCLLRNGALVDARAREEQTPL 501
Score = 72.0 bits (175), Expect = 2e-12
Identities = 54/189 (28%), Positives = 90/189 (47%), Gaps = 10/189 (5%)
Query: 5 LVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAM 64
L+E GA + +G+ PLH AA G LD+A+ L+ + A + G TPL +A
Sbjct: 549 LLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDN 608
Query: 65 EELLQNEVNRQGVDIEAARKE--------EERIMLRDARQWLNSGHINDVRHAKSGGTAL 116
+++ + + G A K ++ ++ A LN G ++ K G T L
Sbjct: 609 QKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIV-TKQGVTPL 666
Query: 117 HVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNK 176
H+A+ +G+T+++ LL+ G ++++ G T LH AA K IL + D + K
Sbjct: 667 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 726
Query: 177 VGQTAFDVA 185
+G T VA
Sbjct: 727 LGYTPLIVA 735
Score = 71.6 bits (174), Expect = 3e-12
Identities = 56/196 (28%), Positives = 92/196 (46%), Gaps = 16/196 (8%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIA- 59
+ K L++ AN N G+ PLH A + + E L+ GA + A+ G TP+ +A
Sbjct: 380 VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA 439
Query: 60 ---EEEAMEELLQNEVNRQGVDIE-------AARKEEERIMLRDARQWLNSGHINDVRHA 109
+ LLQN + +I AAR + ++ R L +G + D R A
Sbjct: 440 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV----RCLLRNGALVDAR-A 494
Query: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
+ T LH+A+ G TE+++LL+Q + +G+TPLH +A G+ + +L++
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554
Query: 170 DMEMVNKVGQTAFDVA 185
+ K G T VA
Sbjct: 555 AHSLATKKGFTPLHVA 570
Score = 71.6 bits (174), Expect = 3e-12
Identities = 54/199 (27%), Positives = 92/199 (46%), Gaps = 16/199 (8%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+V+ L+++ A+ + G+ PLH +A G +D+A L+ GA +G TPL +A
Sbjct: 512 IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAA 571
Query: 61 E----EAMEELLQNEVNRQGVDIE-------AARKEEERIMLRDARQWLNSGHINDVRHA 109
+ + + LLQ AA + +++ L + S H A
Sbjct: 572 KYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA-SPHAT----A 626
Query: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
K+G T LH+AA K ++ L+ G + NI G TPLH A+ G + +L+D
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
Query: 170 DMEMVNKVGQTAFDVADED 188
++ M K G T+ +A ++
Sbjct: 687 NIHMSTKSGLTSLHLAAQE 705
Score = 67.4 bits (163), Expect = 6e-11
Identities = 59/237 (24%), Positives = 108/237 (45%), Gaps = 35/237 (14%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+V+ L+ G++++ +G LH A+ G ++ + L+ +GA++ A + G TPL +A
Sbjct: 79 LVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 138
Query: 61 EE----AMEELLQNEVNRQ----------GVDIEAARKEEERIMLRDARQWLNSGHINDV 106
+E ++ LL+N N+ V ++ + I+L ND
Sbjct: 139 QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----------NDT 187
Query: 107 RHAKSGGTALHVAAAKGYTEVLKLLIQAGYD--------VNIKDYDGWTPLHAAAHWGKE 158
+ K ALH+AA K T+ LL+Q ++ VN G+TPLH AAH+G
Sbjct: 188 K-GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 246
Query: 159 EACRILVDNLCDMEMVNKVGQTAFDVADE-DILGYLEELQKKQNLLHSEKRDKKSPL 214
+L++ ++ + G T VA + ++ L + + ++ RD +PL
Sbjct: 247 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 303
Score = 65.1 bits (157), Expect = 3e-10
Identities = 52/192 (27%), Positives = 94/192 (48%), Gaps = 10/192 (5%)
Query: 2 VKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEE 61
VK L+++ A ++ + LH AA CG+ + + L+ + A+ A G TPL IA +
Sbjct: 348 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACK 407
Query: 62 EAMEELLQNEVNRQGVDIEAARKEEERIM--------LRDARQWLNSGHINDVRHAKSGG 113
+ ++++ V + G I+A + + L L +G DV + + G
Sbjct: 408 KNRIKVMELLV-KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR-GE 465
Query: 114 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 173
TALH+AA G EV++ L++ G V+ + + TPLH A+ GK E ++L+ ++ +
Sbjct: 466 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525
Query: 174 VNKVGQTAFDVA 185
G T ++
Sbjct: 526 ATTNGYTPLHIS 537
Score = 64.3 bits (155), Expect = 5e-10
Identities = 50/192 (26%), Positives = 83/192 (43%), Gaps = 16/192 (8%)
Query: 5 LVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAM 64
L+ GA ++ G PLH A+ G ++ + L+ +G + A +G TPL A
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311
Query: 65 EELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGG----------- 113
+++++ + R G + A K L H+ V+H
Sbjct: 312 DQVVELLLER-GAPLLARTKNG----LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL 366
Query: 114 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 173
TALHVAA G+ V KLL+ + N + +G+TPLH A + + +LV ++
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426
Query: 174 VNKVGQTAFDVA 185
+ + G T VA
Sbjct: 427 ITESGLTPIHVA 438
Score = 63.2 bits (152), Expect = 1e-09
Identities = 43/162 (26%), Positives = 80/162 (49%), Gaps = 27/162 (16%)
Query: 6 VENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAME 65
++ G +IN + G LH AA G++ + + L+G+G+ V + +G+T L IA
Sbjct: 51 LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 110
Query: 66 ELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYT 125
E+++ V ++G +I A +++G T L++AA + +
Sbjct: 111 EVVKVLV-KEGANINA--------------------------QSQNGFTPLYMAAQENHI 143
Query: 126 EVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 167
+V+K L++ G + + DG+TPL A G +A IL++N
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185
Score = 59.7 bits (143), Expect = 1e-08
Identities = 55/208 (26%), Positives = 92/208 (44%), Gaps = 45/208 (21%)
Query: 26 AASCGYLD-IAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARK 84
AA G LD + E+L G G + N G L +A +E L+Q + R G +++A K
Sbjct: 38 AARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR-GSSVDSATK 95
Query: 85 EEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYD 144
+ G TALH+A+ G EV+K+L++ G ++N + +
Sbjct: 96 K--------------------------GNTALHIASLAGQAEVVKVLVKEGANINAQSQN 129
Query: 145 GWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQN--- 201
G+TPL+ AA + + L++N + + G T VA LQ+ N
Sbjct: 130 GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA----------LQQGHNQAV 179
Query: 202 --LLHSEKRDK-KSPLIESTANMDNNQS 226
LL ++ + K + P + A D+ +S
Sbjct: 180 AILLENDTKGKVRLPALHIAARKDDTKS 207
Score = 54.3 bits (129), Expect = 5e-07
Identities = 44/156 (28%), Positives = 67/156 (42%), Gaps = 27/156 (17%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MV L++ GANI+ G LH AA +++A+ L GA A G TPL +A
Sbjct: 677 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVAC 736
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
+++ N + +QG ++ A K+G T LH AA
Sbjct: 737 HYGNVKMV-NFLLKQGANVNA--------------------------KTKNGYTPLHQAA 769
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWG 156
+G+T ++ +L+Q G N +G T L A G
Sbjct: 770 QQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 805
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 85.5 bits (210), Expect = 2e-16
Identities = 64/200 (32%), Positives = 98/200 (49%), Gaps = 20/200 (10%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIA- 59
+VK LV+ GANIN G+ PL+ AA ++D+ ++L+ GA+ +G TPL +A
Sbjct: 112 VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVAL 171
Query: 60 ---EEEAMEELLQNE----VNRQGVDIEAARKEEERIMLRDARQWLNSGHINDV------ 106
+A+ LL+N+ V + I AARK++ + A L + H DV
Sbjct: 172 QQGHNQAVAILLENDTKGKVRLPALHI-AARKDD----TKSAALLLQNDHNADVQSKMMV 226
Query: 107 -RHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILV 165
R +SG T LH+AA G V LL+ G V+ +G TPLH A+ G ++L+
Sbjct: 227 NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLL 286
Query: 166 DNLCDMEMVNKVGQTAFDVA 185
D ++ + G T A
Sbjct: 287 DRGGQIDAKTRDGLTPLHCA 306
Score = 80.5 bits (197), Expect = 7e-15
Identities = 57/199 (28%), Positives = 93/199 (46%), Gaps = 16/199 (8%)
Query: 5 LVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAM 64
L+E GA+ + G+ PLH AA + IA L+ GA V +G TPL +A +E
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 674
Query: 65 EELLQNEVNRQGVDIEAARK----------EEERIMLRDARQWLNSGHINDVRHAKSGGT 114
+++ +++ G +I + K +E+++ + D L + H K G T
Sbjct: 675 TDMVTLLLDK-GANIHMSTKSGLTSLHLAAQEDKVNVADI---LTKHGADQDAHTKLGYT 730
Query: 115 ALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMV 174
L VA G +++ L++ G +VN K +G+TPLH AA G +L+ +
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNAT 790
Query: 175 NKVGQTAFDVADEDILGYL 193
G TA +A LGY+
Sbjct: 791 TANGNTALAIAKR--LGYI 807
Score = 80.1 bits (196), Expect = 9e-15
Identities = 66/230 (28%), Positives = 110/230 (47%), Gaps = 25/230 (10%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MVK L++ G I+ +G PLH AA G+ + E L+ +GA + A G +PL +A
Sbjct: 281 MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAA 340
Query: 61 E----EAMEELLQNEVNRQGVDIE-------AARKEEERI--MLRDARQWLNSGHINDVR 107
+ E ++ LLQ++ V ++ AA R+ +L D R N+ +N
Sbjct: 341 QGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN--- 397
Query: 108 HAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 167
G T LH+A K +V++LL++ G + G TP+H AA G +L+ N
Sbjct: 398 ----GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 453
Query: 168 LCDMEMVNKVGQTAFDVADEDILGYLEE---LQKKQNLLHSEKRDKKSPL 214
++ N G+TA +A G +E L + L+ + R++++PL
Sbjct: 454 GASPDVTNIRGETALHMAAR--AGQVEVVRCLLRNGALVDARAREEQTPL 501
Score = 72.0 bits (175), Expect = 2e-12
Identities = 54/189 (28%), Positives = 90/189 (47%), Gaps = 10/189 (5%)
Query: 5 LVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAM 64
L+E GA + +G+ PLH AA G LD+A+ L+ + A + G TPL +A
Sbjct: 549 LLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDN 608
Query: 65 EELLQNEVNRQGVDIEAARKE--------EERIMLRDARQWLNSGHINDVRHAKSGGTAL 116
+++ + + G A K ++ ++ A LN G ++ K G T L
Sbjct: 609 QKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIV-TKQGVTPL 666
Query: 117 HVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNK 176
H+A+ +G+T+++ LL+ G ++++ G T LH AA K IL + D + K
Sbjct: 667 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 726
Query: 177 VGQTAFDVA 185
+G T VA
Sbjct: 727 LGYTPLIVA 735
Score = 71.6 bits (174), Expect = 3e-12
Identities = 56/196 (28%), Positives = 92/196 (46%), Gaps = 16/196 (8%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIA- 59
+ K L++ AN N G+ PLH A + + E L+ GA + A+ G TP+ +A
Sbjct: 380 VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA 439
Query: 60 ---EEEAMEELLQNEVNRQGVDIE-------AARKEEERIMLRDARQWLNSGHINDVRHA 109
+ LLQN + +I AAR + ++ R L +G + D R A
Sbjct: 440 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV----RCLLRNGALVDAR-A 494
Query: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
+ T LH+A+ G TE+++LL+Q + +G+TPLH +A G+ + +L++
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554
Query: 170 DMEMVNKVGQTAFDVA 185
+ K G T VA
Sbjct: 555 AHSLATKKGFTPLHVA 570
Score = 71.6 bits (174), Expect = 3e-12
Identities = 54/199 (27%), Positives = 92/199 (46%), Gaps = 16/199 (8%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+V+ L+++ A+ + G+ PLH +A G +D+A L+ GA +G TPL +A
Sbjct: 512 IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAA 571
Query: 61 E----EAMEELLQNEVNRQGVDIE-------AARKEEERIMLRDARQWLNSGHINDVRHA 109
+ + + LLQ AA + +++ L + S H A
Sbjct: 572 KYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA-SPHAT----A 626
Query: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
K+G T LH+AA K ++ L+ G + NI G TPLH A+ G + +L+D
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
Query: 170 DMEMVNKVGQTAFDVADED 188
++ M K G T+ +A ++
Sbjct: 687 NIHMSTKSGLTSLHLAAQE 705
Score = 67.4 bits (163), Expect = 6e-11
Identities = 59/237 (24%), Positives = 108/237 (45%), Gaps = 35/237 (14%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+V+ L+ G++++ +G LH A+ G ++ + L+ +GA++ A + G TPL +A
Sbjct: 79 LVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 138
Query: 61 EE----AMEELLQNEVNRQ----------GVDIEAARKEEERIMLRDARQWLNSGHINDV 106
+E ++ LL+N N+ V ++ + I+L ND
Sbjct: 139 QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----------NDT 187
Query: 107 RHAKSGGTALHVAAAKGYTEVLKLLIQAGYD--------VNIKDYDGWTPLHAAAHWGKE 158
+ K ALH+AA K T+ LL+Q ++ VN G+TPLH AAH+G
Sbjct: 188 K-GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 246
Query: 159 EACRILVDNLCDMEMVNKVGQTAFDVADE-DILGYLEELQKKQNLLHSEKRDKKSPL 214
+L++ ++ + G T VA + ++ L + + ++ RD +PL
Sbjct: 247 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 303
Score = 65.1 bits (157), Expect = 3e-10
Identities = 52/192 (27%), Positives = 94/192 (48%), Gaps = 10/192 (5%)
Query: 2 VKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEE 61
VK L+++ A ++ + LH AA CG+ + + L+ + A+ A G TPL IA +
Sbjct: 348 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACK 407
Query: 62 EAMEELLQNEVNRQGVDIEAARKEEERIM--------LRDARQWLNSGHINDVRHAKSGG 113
+ ++++ V + G I+A + + L L +G DV + + G
Sbjct: 408 KNRIKVMELLV-KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR-GE 465
Query: 114 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 173
TALH+AA G EV++ L++ G V+ + + TPLH A+ GK E ++L+ ++ +
Sbjct: 466 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525
Query: 174 VNKVGQTAFDVA 185
G T ++
Sbjct: 526 ATTNGYTPLHIS 537
Score = 64.3 bits (155), Expect = 5e-10
Identities = 50/192 (26%), Positives = 83/192 (43%), Gaps = 16/192 (8%)
Query: 5 LVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAM 64
L+ GA ++ G PLH A+ G ++ + L+ +G + A +G TPL A
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311
Query: 65 EELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGG----------- 113
+++++ + R G + A K L H+ V+H
Sbjct: 312 DQVVELLLER-GAPLLARTKNG----LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL 366
Query: 114 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 173
TALHVAA G+ V KLL+ + N + +G+TPLH A + + +LV ++
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426
Query: 174 VNKVGQTAFDVA 185
+ + G T VA
Sbjct: 427 ITESGLTPIHVA 438
Score = 63.2 bits (152), Expect = 1e-09
Identities = 43/162 (26%), Positives = 80/162 (49%), Gaps = 27/162 (16%)
Query: 6 VENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAME 65
++ G +IN + G LH AA G++ + + L+G+G+ V + +G+T L IA
Sbjct: 51 LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 110
Query: 66 ELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYT 125
E+++ V ++G +I A +++G T L++AA + +
Sbjct: 111 EVVKVLV-KEGANINA--------------------------QSQNGFTPLYMAAQENHI 143
Query: 126 EVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDN 167
+V+K L++ G + + DG+TPL A G +A IL++N
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185
Score = 59.7 bits (143), Expect = 1e-08
Identities = 55/208 (26%), Positives = 92/208 (44%), Gaps = 45/208 (21%)
Query: 26 AASCGYLD-IAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARK 84
AA G LD + E+L G G + N G L +A +E L+Q + R G +++A K
Sbjct: 38 AARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR-GSSVDSATK 95
Query: 85 EEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYD 144
+ G TALH+A+ G EV+K+L++ G ++N + +
Sbjct: 96 K--------------------------GNTALHIASLAGQAEVVKVLVKEGANINAQSQN 129
Query: 145 GWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQN--- 201
G+TPL+ AA + + L++N + + G T VA LQ+ N
Sbjct: 130 GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA----------LQQGHNQAV 179
Query: 202 --LLHSEKRDK-KSPLIESTANMDNNQS 226
LL ++ + K + P + A D+ +S
Sbjct: 180 AILLENDTKGKVRLPALHIAARKDDTKS 207
Score = 54.3 bits (129), Expect = 5e-07
Identities = 44/156 (28%), Positives = 67/156 (42%), Gaps = 27/156 (17%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MV L++ GANI+ G LH AA +++A+ L GA A G TPL +A
Sbjct: 677 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVAC 736
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
+++ N + +QG ++ A K+G T LH AA
Sbjct: 737 HYGNVKMV-NFLLKQGANVNA--------------------------KTKNGYTPLHQAA 769
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWG 156
+G+T ++ +L+Q G N +G T L A G
Sbjct: 770 QQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 805
Score = 47.4 bits (111), Expect = 6e-05
Identities = 131/612 (21%), Positives = 225/612 (36%), Gaps = 98/612 (16%)
Query: 237 IIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESE--AETDKTKPLASVT 294
++E S ES + E + E E + S S ++ EE E++ +T+ T + S
Sbjct: 2218 LMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQTGETKESTKTETTTEIRSEK 2277
Query: 295 NANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEE--ERKDESPATWRLG 352
T+ TV+ T T +K AT SPK+ +R+D+ + +
Sbjct: 2278 EHPTTKDITGGSEERGATVTEDSETSTESFQK---EATLGSPKDTSPKRQDDCTGSCSVA 2334
Query: 353 LRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAP 412
L K G L E A EGQ+ T +S+ + + + +E S T+ A
Sbjct: 2335 LAKETPTG-LTEEAACDEGQR-------TFGSSAHKTQTDSEVQESTATSDETK----AL 2382
Query: 413 TIPRRLASTSDIEEKE----------------NRDSSSLRTSSSYTRRKWEDDLKKNSSV 456
+P T E + +RDS L + + D + S V
Sbjct: 2383 PLPEASVKTDTGTESKPQGVIRSPQGLELALPSRDSEVLSAVADDSLAVSHKDSLEASPV 2442
Query: 457 NEGSTYHK---SCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGS 513
E ++ HK S ++ S+ S+ P + + L + T++ T
Sbjct: 2443 LEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKTELLTEV 2502
Query: 514 SSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTT 573
+S ++ AED + ++ + ++ P++P ++ + +T TT
Sbjct: 2503 ASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTP-------KTT 2555
Query: 574 EVRERRRSYLTPVRDEE-SESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRT 632
+V + + + +E+ SE+ K R T +E K + T
Sbjct: 2556 DVSTPKPAVIHECAEEDDSENGEKKR---------------FTPEEEMFKMV-------T 2593
Query: 633 REQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTT 692
+ + +E E+E K+K+D +K+ +++ES +S + + S DE P T S
Sbjct: 2594 KIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPD--ADCSVDVDE------PKHTGSGED 2645
Query: 693 PSS--SLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQP 750
S L T S +SS + P L + G+ E + P
Sbjct: 2646 ESGVPVLVTSESRKVSSSSESEP-ELAQLKKGADSGLLPE--------PVIRVQPPSPLP 2696
Query: 751 KSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRY----ETS 806
S+ P E V F S + + DT+E K E + DS S
Sbjct: 2697 SSMDSNSSPEE------VQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAV 2750
Query: 807 STSAGDR-YDSL 817
ST A DR YD L
Sbjct: 2751 STEAEDRSYDKL 2762
Score = 42.7 bits (99), Expect = 0.002
Identities = 112/536 (20%), Positives = 198/536 (36%), Gaps = 91/536 (16%)
Query: 133 QAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDI--L 190
+ Y+V K D TP A H EE D E K T + + + +
Sbjct: 2545 EVSYEVTPKTTDVSTPKPAVIHECAEED---------DSENGEKKRFTPEEEMFKMVTKI 2595
Query: 191 GYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESL 250
+EL+++ K++ K S+++ D + S + K T E E + +
Sbjct: 2596 KMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSGEDESGVPVLVTS 2655
Query: 251 EQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTS--STQAAPVAV 308
E KV E + + + D E PL S ++N+S Q PV
Sbjct: 2656 ESRKVSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMDSNSSPEEVQFQPVVS 2715
Query: 309 TTPTVSSGQATPTSPIKKFPTTATK---------ISPKEEERK----------------- 342
T + T P K ++ +S + E+R
Sbjct: 2716 KQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYDKLNRDTDQPKICDGH 2775
Query: 343 -------DESPATWRLGLRK-TG----SYGALAEITASKEGQKEKDTAG----VTRS--- 383
S A GL+ TG + + + + +G EKDT G V+R+
Sbjct: 2776 GCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEKDTEGEELDVSRAESP 2835
Query: 384 ---------ASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKE--NRDS 432
+SS L L ++ KE D + + + T + T + K+ ++DS
Sbjct: 2836 QADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTDETFENLPKDCPSQDS 2895
Query: 433 SSLRTSSSYTRRKWEDDLKKNSSVNE---GSTYHK--SCSFGRRQDDLISSSVPSTTS-- 485
S + ++ DL +N + + S Y S SF ++ + TTS
Sbjct: 2896 SITTQTDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSEESKTQTDANHTTSFH 2955
Query: 486 ---TPTVTSAAGLQKSLLSSTSTTTKITTGSSSAG----TQSSTSNRLWAEDSTEKEKDS 538
+VT + ++ +++S+S+ T ++ S+ G +S + LW E + DS
Sbjct: 2956 SSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQESTLW-----EMQSDS 3010
Query: 539 VPTAV--TIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESE 592
V ++ T+ TVV S +T T + S +E+RE ++ V++EE +
Sbjct: 3011 VSSSFEPTMSATTTVVGEQISKVIITKTDVDS-DSWSEIREDDEAFEARVKEEEQK 3065
Score = 40.8 bits (94), Expect = 0.006
Identities = 136/712 (19%), Positives = 254/712 (35%), Gaps = 99/712 (13%)
Query: 203 LHSEKRDKKSPLIESTANMDNNQSQK--TFKNKETLIIEPEKNASRIESLEQEKVDEEEE 260
L SE + K LI+ TA + + S K + K KE + E+ E +E+ K D E+
Sbjct: 1503 LLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKV 1562
Query: 261 GKKDES-SCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQAT 319
+ S +C+ +E S SE + + + + Q AP+ +T
Sbjct: 1563 NEILRSGTCTRDESSVQSSRSERGLVEEEWVIVSDEEIEEARQKAPLEIT---------- 1612
Query: 320 PTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEG-QKEKDTA 378
++P +I KE + K E +T GL + + KE Q +D A
Sbjct: 1613 ------EYPCVEVRID-KEIKGKVEKDST---GLVNYLTDDLNTCVPLPKEQLQTVQDKA 1662
Query: 379 GVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTS 438
G A + SS + K+ D + P++ + ++EK+ + L+ S
Sbjct: 1663 GKKCEALAVGRSSEKEGKDIPPDETQSTQKQHKPSLGIKKPVRRKLKEKQKQKEEGLQAS 1722
Query: 439 SSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVT---SAAGL 495
+ + +LKK SS + + + ++ P TP + L
Sbjct: 1723 AE------KAELKKGSSEE---SLGEDPGLAPEPLPTVKATSPLIEETPIGSIKDKVKAL 1773
Query: 496 QKSLLSSTSTTTKI---TTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVV 552
QK + +K+ G +++ A S + E+ + P +P+
Sbjct: 1774 QKRVEDEQKGRSKLPIRVKGKEDVPKKTTHRPHPAASPSLKSERHA-------PGSPSPK 1826
Query: 553 NAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQS------- 605
ST + + T + + + S ++P E S + S+ + S
Sbjct: 1827 TERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTK 1886
Query: 606 --RRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSR 663
R S T T E + S T R + E+ + E++ S
Sbjct: 1887 TERHSPVSSTKT---ERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSG 1943
Query: 664 EDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAY 723
+ Q S T +T +++ PVS S T +S S + ++ S+ + A+
Sbjct: 1944 RTDKHQPVS-TAGKT-EKHLPVSPSGKTEKQPPVSPTSKT----ERIEETMSVRELMKAF 1997
Query: 724 SRGITKENEREG---EKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQ 780
G + G K ++K+ ++K + + +E+ +R + T++
Sbjct: 1998 QSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQREAQK----TENQTIKRG 2053
Query: 781 EQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKD 840
++ T +K+ + SI + + ++ S S EE S + K+
Sbjct: 2054 QRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVPEEESHRESEVPKE 2113
Query: 841 D------------------STDFKKLYEQILAENEKL----------KAQLH 864
STDF ++ +Q L +N+K KAQLH
Sbjct: 2114 KMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDKYQQFRLSEETEKAQLH 2165
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 82.0 bits (201), Expect = 2e-15
Identities = 76/223 (34%), Positives = 100/223 (44%), Gaps = 39/223 (17%)
Query: 2 VKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIA-- 59
V+ L+ ++N DNE PLHAAA G +I E LI GA V A +S+ TPL A
Sbjct: 24 VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVA 83
Query: 60 --EEEAMEELLQNEVNRQGVD--------IEAARKEEE------------RIMLRDARQW 97
EEA++ LL++ + D I AA K + + R R
Sbjct: 84 SCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTA 143
Query: 98 LN----SGHINDVRHAKSGGT-----------ALHVAAAKGYTEVLKLLIQAGYDVNIKD 142
L+ SGH V+ S G A+H AA G+ EV+KLL+ G +V KD
Sbjct: 144 LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD 203
Query: 143 YDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 185
+TPLHAAA G + L+D DM N G T VA
Sbjct: 204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA 246
Score = 81.6 bits (200), Expect = 3e-15
Identities = 73/264 (27%), Positives = 117/264 (44%), Gaps = 47/264 (17%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIA- 59
+VK LV +GA + D + + PLHAAAS G + + ++L+ G + N+ G+TPL +A
Sbjct: 188 VVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVAC 247
Query: 60 ---EEEAMEELLQ-----NEVNRQG------------------------VDIEAARKEEE 87
++ + EL+ N+ N +G D+ K+ +
Sbjct: 248 YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK 307
Query: 88 RIMLRDA--------RQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVN 139
+ A + + SG + D K+G T LH+AA G+ ++ LI +G D
Sbjct: 308 TPLHMTALHGRFSRSQTIIQSGAVIDCED-KNGNTPLHIAARYGHELLINTLITSGADTA 366
Query: 140 IKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKK 199
+ G PLH AA G + CR L+ + D++ + G+T A G LE L
Sbjct: 367 KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAG--GNLECLNLL 424
Query: 200 QNL-LHSEKRDK--KSPLIESTAN 220
N K+DK +SPL + AN
Sbjct: 425 LNTGADFNKKDKFGRSPLHYAAAN 448
Score = 68.6 bits (166), Expect = 3e-11
Identities = 71/258 (27%), Positives = 117/258 (45%), Gaps = 21/258 (8%)
Query: 2 VKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEE 61
V+ L+++ A++N D PLH AA+ + AE L+ ++V + G T L A
Sbjct: 90 VQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAF 149
Query: 62 EAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLN-SGHINDVRHAKSGG------- 113
E+++ ++R G +I A K++ R A W GHI V+ S G
Sbjct: 150 SGHGEMVKLLLSR-GANINAFDKKDRR-----AIHWAAYMGHIEVVKLLVSHGAEVTCKD 203
Query: 114 ----TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
T LH AA+ G V+K L+ G D+N + G TPLH A + G++ L+D
Sbjct: 204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263
Query: 170 DMEMVNKVGQTAFDVADEDILG--YLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQ 227
+ N+ G T A G LE L ++ + +D K+PL + + ++SQ
Sbjct: 264 IVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQ 323
Query: 228 KTFKNKETLIIEPEKNAS 245
++ + E +KN +
Sbjct: 324 TIIQSGAVIDCE-DKNGN 340
Score = 64.7 bits (156), Expect = 4e-10
Identities = 57/189 (30%), Positives = 93/189 (49%), Gaps = 29/189 (15%)
Query: 2 VKFLVENGANINQPDNEGWIPLH-AAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIA- 59
+ L+ GA+ N+ D G PLH AAA+C Y + L+G GA V ++ G TPL A
Sbjct: 421 LNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFA-LVGSGASVNDLDERGCTPLHYAA 479
Query: 60 ----EEEAMEELLQNEVN-----RQGVD-IEAARKEEERIMLRDARQWLNSGHINDVRHA 109
+ + +E LL+N+ N +QG + + + R+ L Q + S DV
Sbjct: 480 TSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCL----QLIASETPLDVLME 535
Query: 110 KSGG------------TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGK 157
SG + LH+AA G+ + L++L+Q+ D+++++ G TPL AA G
Sbjct: 536 TSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGH 595
Query: 158 EEACRILVD 166
E +L++
Sbjct: 596 VECVDVLIN 604
Score = 60.1 bits (144), Expect = 1e-08
Identities = 46/154 (29%), Positives = 69/154 (44%), Gaps = 14/154 (9%)
Query: 12 INQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNE 71
+N D++G PLHAAA +++ + L+ A V +V+S G TPL +A E ++
Sbjct: 816 VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Query: 72 VNRQGVDIE------------AARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVA 119
V+ ++ A K E L + + IN A T LHVA
Sbjct: 876 VSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQ--TPLHVA 933
Query: 120 AAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAA 153
A G T V++ L+ G V D +G+TP A A
Sbjct: 934 ARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967
Score = 53.9 bits (128), Expect = 7e-07
Identities = 64/241 (26%), Positives = 104/241 (43%), Gaps = 28/241 (11%)
Query: 2 VKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGA----VNSEGDTPLD 57
V L+++GA D+ G P+H +A+CG++ + L+ A + A ++ G T L
Sbjct: 702 VDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALH 761
Query: 58 IA----EEEAMEELLQNEV--NRQGVDIEAAR------KEEERIMLRDARQWLNSGHIND 105
A E +E LL+ EV +G E ML D L + +N
Sbjct: 762 WACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDT---LGASIVNA 818
Query: 106 VRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILV 165
G T LH AA + E L+LL+ VN D G TPL AA G+ +LV
Sbjct: 819 TD--SKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLV 876
Query: 166 DNL-CDMEMVNKVGQTAFDVA-----DEDILGYLEELQKKQNLLHSEKRDKKSPLIESTA 219
+ ++ + + TA +A + L LE++ + NL+++ ++PL +
Sbjct: 877 SSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDR-NLINATNAALQTPLHVAAR 935
Query: 220 N 220
N
Sbjct: 936 N 936
Score = 49.7 bits (117), Expect = 1e-05
Identities = 47/182 (25%), Positives = 81/182 (44%), Gaps = 12/182 (6%)
Query: 2 VKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSE-GDTPLDIA- 59
++ LV++ +++ ++ G PL AA G+++ + LI QGA + + TP+ A
Sbjct: 566 LEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAA 625
Query: 60 ---EEEAMEELLQNEVNRQGVDIEAARKEEERIM------LRDARQWLNSGHINDVRHAK 110
E + L+ N + VDI+ + ++ LN G D + K
Sbjct: 626 TNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKD-K 684
Query: 111 SGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCD 170
G TALH A G+ E + L+Q G ++D G TP+H +A G L+ +
Sbjct: 685 WGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAAS 744
Query: 171 ME 172
M+
Sbjct: 745 MD 746
Score = 49.3 bits (116), Expect = 2e-05
Identities = 49/174 (28%), Positives = 78/174 (44%), Gaps = 30/174 (17%)
Query: 12 INQPDNEGWI-PLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQN 70
++ DN I PLH AA G+ E L+ + NS G TPLD+A + E +
Sbjct: 542 LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 601
Query: 71 EVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKL 130
+N QG I ++ I+ R T +H AA G++E L+L
Sbjct: 602 LIN-QGASILV----KDYILKR---------------------TPIHAAATNGHSECLRL 635
Query: 131 LI---QAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTA 181
LI + V+I+D +G TPL + G + L++ +++ +K G+TA
Sbjct: 636 LIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTA 689
Score = 33.5 bits (75), Expect = 0.96
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 119 AAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILV 165
A G + ++ LI DVN +D + TPLHAAA+ G E +L+
Sbjct: 15 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI 61
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 82.0 bits (201), Expect = 2e-15
Identities = 56/179 (31%), Positives = 89/179 (49%), Gaps = 4/179 (2%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+V+ LV GAN+N +G+ PL+ AA +L++ +FL+ GA+ +G TPL +A
Sbjct: 126 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 185
Query: 61 EEAMEELLQNEVN---RQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALH 117
++ E ++ + +N + V + A R A L + DV +K+G T LH
Sbjct: 186 QQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-SKTGFTPLH 244
Query: 118 VAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNK 176
+AA V +LL+ G VN +G TPLH A+ G R+L+D +E K
Sbjct: 245 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK 303
Score = 81.3 bits (199), Expect = 4e-15
Identities = 85/339 (25%), Positives = 146/339 (43%), Gaps = 38/339 (11%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+VK L+ G + + P G+ PLH AA +++A L+ G A + +G TPL +A
Sbjct: 617 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 676
Query: 61 EEAMEELLQ---------NEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKS 111
+E E++ N N+ G+ +E + + D + G + D +
Sbjct: 677 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL--IKHGVMVDAT-TRM 733
Query: 112 GGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDM 171
G T LHVA+ G +++K L+Q DVN K G++PLH AA G + +L+ N
Sbjct: 734 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 793
Query: 172 EMVNKVGQTAFDVADEDILGYLE-------ELQKKQNLLHSEKRDKKSP-LIESTANM-- 221
V+ G T +A LGY+ + +L S+K P ++ ++
Sbjct: 794 NEVSSDGTTPLAIAKR--LGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSE 851
Query: 222 DNNQSQKTFKNKETLIIEPEKNASRIESLEQE------KVDEEEEGKK-DESSCSSEE-- 272
D + T +E + + E+ SR E+E K+D+ E C+ E
Sbjct: 852 DEGTAHITIMGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 911
Query: 273 ----DEEDDSESEAETDKTKPLASVTNANTS-STQAAPV 306
+E++ + E + D P + T + + S A+PV
Sbjct: 912 VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPV 950
Score = 77.0 bits (188), Expect = 8e-14
Identities = 56/191 (29%), Positives = 90/191 (47%), Gaps = 6/191 (3%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+++ L++ GA+I+ G PLH A+ G+L I + L+ +GA N + +TPL +A
Sbjct: 419 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 478
Query: 61 E----EAMEELLQNE--VNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGT 114
E + LLQN+ VN + D + RI + + L + N +G T
Sbjct: 479 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 538
Query: 115 ALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMV 174
LH+AA +G+ E + L++ G+TPLH AA +GK +L++
Sbjct: 539 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA 598
Query: 175 NKVGQTAFDVA 185
K G T VA
Sbjct: 599 GKNGLTPLHVA 609
Score = 76.6 bits (187), Expect = 1e-13
Identities = 55/191 (28%), Positives = 83/191 (43%), Gaps = 6/191 (3%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ K L++ GA N G+ PLH A ++ + E L+ GA + AV G TPL +A
Sbjct: 386 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 445
Query: 61 EEAMEELLQNEVNR------QGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGT 114
+++N + R V +E R + ++L AK T
Sbjct: 446 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 505
Query: 115 ALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMV 174
LH AA G+T ++KLL++ + N+ G TPLH AA G E L++ +
Sbjct: 506 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 565
Query: 175 NKVGQTAFDVA 185
K G T VA
Sbjct: 566 TKKGFTPLHVA 576
Score = 71.6 bits (174), Expect = 3e-12
Identities = 60/229 (26%), Positives = 107/229 (46%), Gaps = 23/229 (10%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MV+ L++ GA I + PLH AA G++ I+E L+ GA + A G +P+ +A
Sbjct: 287 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 346
Query: 61 E----EAMEELLQNEVNRQGVDIE-------AARKEEERIMLRDARQWLNSGHINDVRHA 109
+ + + LLQ + + ++ AA R+ A+ L+ G + R A
Sbjct: 347 QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV----AKVLLDKGAKPNSR-A 401
Query: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
+G T LH+A K + V++LL++ G ++ G TPLH A+ G + L+
Sbjct: 402 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 461
Query: 170 DMEMVNKVGQTAFDVA----DEDILGYLEELQKKQNLLHSEKRDKKSPL 214
+ N +T +A ++ YL + + K N ++ +D ++PL
Sbjct: 462 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN---AKAKDDQTPL 507
Score = 67.4 bits (163), Expect = 6e-11
Identities = 53/180 (29%), Positives = 86/180 (47%), Gaps = 24/180 (13%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ K+L++N A +N + PLH AA G+ ++ + L+ A+ + G TPL IA
Sbjct: 485 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 544
Query: 61 EEAMEE----LLQNEVNRQGVDIE-------AAR----KEEERIMLRDARQWLNSGHIND 105
E E LL+ E ++ + + AA+ + E ++ RDA H N
Sbjct: 545 REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA-------HPNA 597
Query: 106 VRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILV 165
K+G T LHVA +++KLL+ G + ++G+TPLH AA + E R L+
Sbjct: 598 A--GKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 655
Score = 63.5 bits (153), Expect = 9e-10
Identities = 55/196 (28%), Positives = 87/196 (44%), Gaps = 20/196 (10%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MV L+ + +G LH AA G ++ L+ GA+V A + +G TPL +A
Sbjct: 93 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 152
Query: 61 E----EAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGT-- 114
+ E ++ LL+N N+ E+ L A L GH N V H + GT
Sbjct: 153 QENHLEVVKFLLENGANQN------VATEDGFTPLAVA---LQQGHENVVAHLINYGTKG 203
Query: 115 -----ALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
ALH+AA T +L+Q + ++ G+TPLH AAH+ ++L++
Sbjct: 204 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 263
Query: 170 DMEMVNKVGQTAFDVA 185
+ + G T +A
Sbjct: 264 SVNFTPQNGITPLHIA 279
Score = 54.3 bits (129), Expect = 5e-07
Identities = 45/160 (28%), Positives = 68/160 (42%), Gaps = 27/160 (16%)
Query: 26 AASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKE 85
AA G LD A + G + N G L +A +E +++ +E KE
Sbjct: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMV----------VELLHKE 101
Query: 86 EERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDG 145
I+L K G TALH+AA G EV++ L+ G +VN + G
Sbjct: 102 ---IILETT--------------TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 144
Query: 146 WTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 185
+TPL+ AA E + L++N + + + G T VA
Sbjct: 145 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 184
Score = 53.9 bits (128), Expect = 7e-07
Identities = 40/161 (24%), Positives = 72/161 (44%), Gaps = 27/161 (16%)
Query: 6 VENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAME 65
+ NG +IN + G LH A+ G++ + L+ + + +G+T L IA +
Sbjct: 65 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 124
Query: 66 ELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYT 125
E+++ VN G ++ A ++ G T L++AA + +
Sbjct: 125 EVVRELVN-YGANVNA--------------------------QSQKGFTPLYMAAQENHL 157
Query: 126 EVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVD 166
EV+K L++ G + N+ DG+TPL A G E L++
Sbjct: 158 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 198
Score = 33.9 bits (76), Expect = 0.73
Identities = 37/160 (23%), Positives = 73/160 (45%), Gaps = 14/160 (8%)
Query: 57 DIAEEEAMEELLQNEVNRQGVDIEAARKEEERI---MLRDARQWLNSGHINDVRHA---- 109
DI + E+ + E NR+ + RK++ LR AR ++ +R+
Sbjct: 13 DIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDIN 72
Query: 110 ---KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVD 166
++G LH+A+ +G+ +++ L+ + G T LH AA G++E R LV+
Sbjct: 73 TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN 132
Query: 167 NLCDMEMVNKVGQTAFDVADE----DILGYLEELQKKQNL 202
++ ++ G T +A + +++ +L E QN+
Sbjct: 133 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 172
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 82.0 bits (201), Expect = 2e-15
Identities = 56/179 (31%), Positives = 89/179 (49%), Gaps = 4/179 (2%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+V+ LV GAN+N +G+ PL+ AA +L++ +FL+ GA+ +G TPL +A
Sbjct: 93 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 152
Query: 61 EEAMEELLQNEVN---RQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALH 117
++ E ++ + +N + V + A R A L + DV +K+G T LH
Sbjct: 153 QQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-SKTGFTPLH 211
Query: 118 VAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNK 176
+AA V +LL+ G VN +G TPLH A+ G R+L+D +E K
Sbjct: 212 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
Score = 80.1 bits (196), Expect = 9e-15
Identities = 68/289 (23%), Positives = 127/289 (43%), Gaps = 36/289 (12%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+VK L+ G + + P G+ PLH AA +++A L+ G A + +G TPL +A
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
+E E++ +++Q +G++ + KSG T LH+ A
Sbjct: 644 QEGHAEMVALLLSKQA-----------------------NGNLGN----KSGLTPLHLVA 676
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
+G+ V +LI+ G V+ G+TPLH A+H+G + + L+ + D+ K+G +
Sbjct: 677 QEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYS 736
Query: 181 AFDVADE----DILGYLEELQKKQNLLHSEKRDKKSPL--IESTANMDNNQSQKTFKNKE 234
A + DI+ L + N + S D +PL + + K ++
Sbjct: 737 PLHQAAQQGHTDIVTLLLKNGASPNEVSS---DGTTPLAIAKRLGYISVTDVLKVVTDET 793
Query: 235 TLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAE 283
+ ++ +K+ E +D E+ ++ S +E + D + E E
Sbjct: 794 SFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKE 842
Score = 77.0 bits (188), Expect = 8e-14
Identities = 56/191 (29%), Positives = 90/191 (47%), Gaps = 6/191 (3%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+++ L++ GA+I+ G PLH A+ G+L I + L+ +GA N + +TPL +A
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
Query: 61 E----EAMEELLQNE--VNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGT 114
E + LLQN+ VN + D + RI + + L + N +G T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
Query: 115 ALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMV 174
LH+AA +G+ E + L++ G+TPLH AA +GK +L++
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA 565
Query: 175 NKVGQTAFDVA 185
K G T VA
Sbjct: 566 GKNGLTPLHVA 576
Score = 76.6 bits (187), Expect = 1e-13
Identities = 55/191 (28%), Positives = 83/191 (43%), Gaps = 6/191 (3%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ K L++ GA N G+ PLH A ++ + E L+ GA + AV G TPL +A
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 61 EEAMEELLQNEVNR------QGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGT 114
+++N + R V +E R + ++L AK T
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472
Query: 115 ALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMV 174
LH AA G+T ++KLL++ + N+ G TPLH AA G E L++ +
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 175 NKVGQTAFDVA 185
K G T VA
Sbjct: 533 TKKGFTPLHVA 543
Score = 71.6 bits (174), Expect = 3e-12
Identities = 60/229 (26%), Positives = 107/229 (46%), Gaps = 23/229 (10%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MV+ L++ GA I + PLH AA G++ I+E L+ GA + A G +P+ +A
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313
Query: 61 E----EAMEELLQNEVNRQGVDIE-------AARKEEERIMLRDARQWLNSGHINDVRHA 109
+ + + LLQ + + ++ AA R+ A+ L+ G + R A
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV----AKVLLDKGAKPNSR-A 368
Query: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
+G T LH+A K + V++LL++ G ++ G TPLH A+ G + L+
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428
Query: 170 DMEMVNKVGQTAFDVA----DEDILGYLEELQKKQNLLHSEKRDKKSPL 214
+ N +T +A ++ YL + + K N ++ +D ++PL
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN---AKAKDDQTPL 474
Score = 67.4 bits (163), Expect = 6e-11
Identities = 53/180 (29%), Positives = 86/180 (47%), Gaps = 24/180 (13%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ K+L++N A +N + PLH AA G+ ++ + L+ A+ + G TPL IA
Sbjct: 452 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Query: 61 EEAMEE----LLQNEVNRQGVDIE-------AAR----KEEERIMLRDARQWLNSGHIND 105
E E LL+ E ++ + + AA+ + E ++ RDA H N
Sbjct: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA-------HPNA 564
Query: 106 VRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILV 165
K+G T LHVA +++KLL+ G + ++G+TPLH AA + E R L+
Sbjct: 565 A--GKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Score = 63.5 bits (153), Expect = 9e-10
Identities = 55/196 (28%), Positives = 87/196 (44%), Gaps = 20/196 (10%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MV L+ + +G LH AA G ++ L+ GA+V A + +G TPL +A
Sbjct: 60 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119
Query: 61 E----EAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGT-- 114
+ E ++ LL+N N+ E+ L A L GH N V H + GT
Sbjct: 120 QENHLEVVKFLLENGANQN------VATEDGFTPLAVA---LQQGHENVVAHLINYGTKG 170
Query: 115 -----ALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
ALH+AA T +L+Q + ++ G+TPLH AAH+ ++L++
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
Query: 170 DMEMVNKVGQTAFDVA 185
+ + G T +A
Sbjct: 231 SVNFTPQNGITPLHIA 246
Score = 54.3 bits (129), Expect = 5e-07
Identities = 45/160 (28%), Positives = 68/160 (42%), Gaps = 27/160 (16%)
Query: 26 AASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKE 85
AA G LD A + G + N G L +A +E +++ +E KE
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMV----------VELLHKE 68
Query: 86 EERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDG 145
I+L K G TALH+AA G EV++ L+ G +VN + G
Sbjct: 69 ---IILETT--------------TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 146 WTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 185
+TPL+ AA E + L++N + + + G T VA
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Score = 53.9 bits (128), Expect = 7e-07
Identities = 40/161 (24%), Positives = 72/161 (44%), Gaps = 27/161 (16%)
Query: 6 VENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAME 65
+ NG +IN + G LH A+ G++ + L+ + + +G+T L IA +
Sbjct: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91
Query: 66 ELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYT 125
E+++ VN G ++ A ++ G T L++AA + +
Sbjct: 92 EVVRELVN-YGANVNA--------------------------QSQKGFTPLYMAAQENHL 124
Query: 126 EVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVD 166
EV+K L++ G + N+ DG+TPL A G E L++
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 165
Score = 32.0 bits (71), Expect = 2.8
Identities = 24/97 (24%), Positives = 49/97 (50%), Gaps = 4/97 (4%)
Query: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
++G LH+A+ +G+ +++ L+ + G T LH AA G++E R LV+
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102
Query: 170 DMEMVNKVGQTAFDVADE----DILGYLEELQKKQNL 202
++ ++ G T +A + +++ +L E QN+
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 82.0 bits (201), Expect = 2e-15
Identities = 56/179 (31%), Positives = 89/179 (49%), Gaps = 4/179 (2%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+V+ LV GAN+N +G+ PL+ AA +L++ +FL+ GA+ +G TPL +A
Sbjct: 93 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 152
Query: 61 EEAMEELLQNEVN---RQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALH 117
++ E ++ + +N + V + A R A L + DV +K+G T LH
Sbjct: 153 QQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-SKTGFTPLH 211
Query: 118 VAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNK 176
+AA V +LL+ G VN +G TPLH A+ G R+L+D +E K
Sbjct: 212 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
Score = 80.1 bits (196), Expect = 9e-15
Identities = 68/289 (23%), Positives = 127/289 (43%), Gaps = 36/289 (12%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+VK L+ G + + P G+ PLH AA +++A L+ G A + +G TPL +A
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Query: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
+E E++ +++Q +G++ + KSG T LH+ A
Sbjct: 644 QEGHAEMVALLLSKQA-----------------------NGNLGN----KSGLTPLHLVA 676
Query: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
+G+ V +LI+ G V+ G+TPLH A+H+G + + L+ + D+ K+G +
Sbjct: 677 QEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYS 736
Query: 181 AFDVADE----DILGYLEELQKKQNLLHSEKRDKKSPL--IESTANMDNNQSQKTFKNKE 234
A + DI+ L + N + S D +PL + + K ++
Sbjct: 737 PLHQAAQQGHTDIVTLLLKNGASPNEVSS---DGTTPLAIAKRLGYISVTDVLKVVTDET 793
Query: 235 TLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAE 283
+ ++ +K+ E +D E+ ++ S +E + D + E E
Sbjct: 794 SFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKE 842
Score = 77.0 bits (188), Expect = 8e-14
Identities = 56/191 (29%), Positives = 90/191 (47%), Gaps = 6/191 (3%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+++ L++ GA+I+ G PLH A+ G+L I + L+ +GA N + +TPL +A
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
Query: 61 E----EAMEELLQNE--VNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGT 114
E + LLQN+ VN + D + RI + + L + N +G T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
Query: 115 ALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMV 174
LH+AA +G+ E + L++ G+TPLH AA +GK +L++
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA 565
Query: 175 NKVGQTAFDVA 185
K G T VA
Sbjct: 566 GKNGLTPLHVA 576
Score = 76.6 bits (187), Expect = 1e-13
Identities = 55/191 (28%), Positives = 83/191 (43%), Gaps = 6/191 (3%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ K L++ GA N G+ PLH A ++ + E L+ GA + AV G TPL +A
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 61 EEAMEELLQNEVNR------QGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGT 114
+++N + R V +E R + ++L AK T
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472
Query: 115 ALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMV 174
LH AA G+T ++KLL++ + N+ G TPLH AA G E L++ +
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 175 NKVGQTAFDVA 185
K G T VA
Sbjct: 533 TKKGFTPLHVA 543
Score = 71.6 bits (174), Expect = 3e-12
Identities = 60/229 (26%), Positives = 107/229 (46%), Gaps = 23/229 (10%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MV+ L++ GA I + PLH AA G++ I+E L+ GA + A G +P+ +A
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313
Query: 61 E----EAMEELLQNEVNRQGVDIE-------AARKEEERIMLRDARQWLNSGHINDVRHA 109
+ + + LLQ + + ++ AA R+ A+ L+ G + R A
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV----AKVLLDKGAKPNSR-A 368
Query: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
+G T LH+A K + V++LL++ G ++ G TPLH A+ G + L+
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428
Query: 170 DMEMVNKVGQTAFDVA----DEDILGYLEELQKKQNLLHSEKRDKKSPL 214
+ N +T +A ++ YL + + K N ++ +D ++PL
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN---AKAKDDQTPL 474
Score = 67.4 bits (163), Expect = 6e-11
Identities = 53/180 (29%), Positives = 86/180 (47%), Gaps = 24/180 (13%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
+ K+L++N A +N + PLH AA G+ ++ + L+ A+ + G TPL IA
Sbjct: 452 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Query: 61 EEAMEE----LLQNEVNRQGVDIE-------AAR----KEEERIMLRDARQWLNSGHIND 105
E E LL+ E ++ + + AA+ + E ++ RDA H N
Sbjct: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA-------HPNA 564
Query: 106 VRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILV 165
K+G T LHVA +++KLL+ G + ++G+TPLH AA + E R L+
Sbjct: 565 A--GKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Score = 63.5 bits (153), Expect = 9e-10
Identities = 55/196 (28%), Positives = 87/196 (44%), Gaps = 20/196 (10%)
Query: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
MV L+ + +G LH AA G ++ L+ GA+V A + +G TPL +A
Sbjct: 60 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119
Query: 61 E----EAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGT-- 114
+ E ++ LL+N N+ E+ L A L GH N V H + GT
Sbjct: 120 QENHLEVVKFLLENGANQN------VATEDGFTPLAVA---LQQGHENVVAHLINYGTKG 170
Query: 115 -----ALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
ALH+AA T +L+Q + ++ G+TPLH AAH+ ++L++
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
Query: 170 DMEMVNKVGQTAFDVA 185
+ + G T +A
Sbjct: 231 SVNFTPQNGITPLHIA 246
Score = 54.3 bits (129), Expect = 5e-07
Identities = 45/160 (28%), Positives = 68/160 (42%), Gaps = 27/160 (16%)
Query: 26 AASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKE 85
AA G LD A + G + N G L +A +E +++ +E KE
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMV----------VELLHKE 68
Query: 86 EERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDG 145
I+L K G TALH+AA G EV++ L+ G +VN + G
Sbjct: 69 ---IILETT--------------TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 146 WTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 185
+TPL+ AA E + L++N + + + G T VA
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Score = 53.9 bits (128), Expect = 7e-07
Identities = 40/161 (24%), Positives = 72/161 (44%), Gaps = 27/161 (16%)
Query: 6 VENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAME 65
+ NG +IN + G LH A+ G++ + L+ + + +G+T L IA +
Sbjct: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91
Query: 66 ELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYT 125
E+++ VN G ++ A ++ G T L++AA + +
Sbjct: 92 EVVRELVN-YGANVNA--------------------------QSQKGFTPLYMAAQENHL 124
Query: 126 EVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVD 166
EV+K L++ G + N+ DG+TPL A G E L++
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 165
Score = 32.0 bits (71), Expect = 2.8
Identities = 24/97 (24%), Positives = 49/97 (50%), Gaps = 4/97 (4%)
Query: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169
++G LH+A+ +G+ +++ L+ + G T LH AA G++E R LV+
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102
Query: 170 DMEMVNKVGQTAFDVADE----DILGYLEELQKKQNL 202
++ ++ G T +A + +++ +L E QN+
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.303 0.120 0.315
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,707,471
Number of Sequences: 37866
Number of extensions: 1739960
Number of successful extensions: 60731
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1134
Number of HSP's successfully gapped in prelim test: 1406
Number of HSP's that attempted gapping in prelim test: 15004
Number of HSP's gapped (non-prelim): 21559
length of query: 943
length of database: 18,247,518
effective HSP length: 112
effective length of query: 831
effective length of database: 14,006,526
effective search space: 11639423106
effective search space used: 11639423106
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.