Search of human proteins with 21955154

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21955154 NLR family, pyrin domain containing 12 isoform 2
[Homo sapiens]
         (1061 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho...  2165   0.0  
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho...   916   0.0  
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom...   916   0.0  
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho...   866   0.0  
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho...   857   0.0  
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom...   811   0.0  
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]     672   0.0  
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]      556   e-158
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H...   519   e-147
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]     509   e-144
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]   494   e-139
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo...   492   e-139
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom...   492   e-139
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom...   492   e-139
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]       488   e-137
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom...   488   e-137
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom...   488   e-137
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]      463   e-130
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso...   444   e-124
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof...   443   e-124
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]      429   e-120
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof...   420   e-117
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho...   406   e-113
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]    391   e-108
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]     346   8e-95
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]          283   6e-76
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]          283   6e-76
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]          283   6e-76
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]          283   6e-76
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]          283   6e-76

>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
            sapiens]
          Length = 1061

 Score = 2165 bits (5609), Expect = 0.0
 Identities = 1061/1061 (100%), Positives = 1061/1061 (100%)

Query: 1    MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL 60
            MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL
Sbjct: 1    MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL 60

Query: 61   ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT 120
            ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
Sbjct: 61   ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT 120

Query: 121  PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG 180
            PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
Sbjct: 121  PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG 180

Query: 181  RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF 240
            RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
Sbjct: 181  RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF 240

Query: 241  QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK 300
            QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
Sbjct: 241  QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK 300

Query: 301  PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV 360
            PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
Sbjct: 301  PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV 360

Query: 361  EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG 420
            EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
Sbjct: 361  EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG 420

Query: 421  GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD 480
            GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
Sbjct: 421  GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD 480

Query: 481  LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD 540
            LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
Sbjct: 481  LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD 540

Query: 541  VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ 600
            VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
Sbjct: 541  VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ 600

Query: 601  SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA 660
            SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
Sbjct: 601  SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA 660

Query: 661  QVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSL 720
            QVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSL
Sbjct: 661  QVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSL 720

Query: 721  YRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGN 780
            YRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGN
Sbjct: 721  YRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGN 780

Query: 781  GVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALE 840
            GVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALE
Sbjct: 781  GVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALE 840

Query: 841  DLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLG 900
            DLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLG
Sbjct: 841  DLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLG 900

Query: 901  VLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWL 960
            VLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWL
Sbjct: 901  VLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWL 960

Query: 961  LAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCK 1020
            LAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCK
Sbjct: 961  LAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCK 1020

Query: 1021 RLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC 1061
            RLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
Sbjct: 1021 RLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC 1061


>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
            sapiens]
          Length = 1036

 Score =  916 bits (2368), Expect = 0.0
 Identities = 504/1072 (47%), Positives = 682/1072 (63%), Gaps = 72/1072 (6%)

Query: 11   CRLSTYLEELEAVELKKFKLYLGT-ATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69
            C+L+ YLE+LE V+LKKFK++L     + G   +P G  EKA  +++A L+I   G E+A
Sbjct: 8    CKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKA 67

Query: 70   WRLALSTFERINRKDLWERGQRE------DLVRDTPPG---GPSSLGNQSTCLLE----V 116
            W +A+  F  INR+DL+E+ +R+      D  R + P       S+  +   LLE    +
Sbjct: 68   WAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRI 127

Query: 117  SLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQL 176
            S+   +KD ++ YR YVR +F+ +EDRNARLGE V+L+ RYTRL L+KEH +  + +Q+L
Sbjct: 128  SICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQEL 187

Query: 177  LDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWAD 236
            L  G+   +T     SPIK+E LF+PD+E  EP  TVV QGAAGIGK++LA K+MLDWA 
Sbjct: 188  LAIGK--TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWAS 245

Query: 237  GKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGF 296
            G L+Q RFDYLFYI+CRE++   T+ S+ DLI SC P+P+ P+ +++R P R+LF++DGF
Sbjct: 246  GTLYQDRFDYLFYIHCREVSL-VTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGF 304

Query: 297  DELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEH 356
            DEL+ +F +  GP C  W++    ++LL+SLIRKKLLPE SLLITTRP ALEKL  LL+H
Sbjct: 305  DELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDH 364

Query: 357  PRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQ 416
            PRHVEILGFSEA+RKEYF+KYF +  QA   F+ +++NE LFTMCF+PLVCW+VCT L+Q
Sbjct: 365  PRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQ 424

Query: 417  QLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILF 476
            Q+E G  L QTS+TTTAVY+ +L SL+QP+ G+       +  GLCSLAADG+WNQKILF
Sbjct: 425  QMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILF 484

Query: 477  EEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAG 536
            EE DLR HGL   DVSAFL MN+FQK+++CE++YSFIH++FQEFFAAMYY+L+E + G  
Sbjct: 485  EESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRT 544

Query: 537  ---------PDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHI 587
                     P +DVT LL  Y   E+ +L    RFLFGL+N+E  S+LEK L  K+S  I
Sbjct: 545  NVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQI 604

Query: 588  KMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEH 647
            +++LL+WI+ KA++    +Q   LE F CLYE+QEE+F+Q+A+ +F  I + N++++M+H
Sbjct: 605  RLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEI-NLSTRMDH 663

Query: 648  MVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAA 707
            MVSSFC++ C   + L L G  ++   E+      G H  +VQ                 
Sbjct: 664  MVSSFCIENCHRVESLSL-GFLHNMPKEEEEEEKEGRHLDMVQ----------------- 705

Query: 708  ALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALI 767
              C  P+        +A  S G                   L    ++SS C  L + L 
Sbjct: 706  --CVLPSS------SHAACSHG-------------------LVNSHLTSSFCRGLFSVLS 738

Query: 768  ANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNP 827
             +++LT +DLS N +G PGM +LCE L+HP C ++ + L +C L    C +++ VL +N 
Sbjct: 739  TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798

Query: 828  HLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLR 887
             LVELDL+ NAL D G+RLLC GL+H +C L+ LWL  C LT+A C +LAS LS + SL 
Sbjct: 799  KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858

Query: 888  ELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELD 947
             L +  N LGD GV +LCE  ++P C LQ L L    L S  C  LS VL  N NL  L 
Sbjct: 859  RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 918

Query: 948  LSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTN 1007
            L  N LGD G+ LL EGL HP C+LQ L LD+C LT+  C +L   L  +Q+L  L L N
Sbjct: 919  LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGN 978

Query: 1008 NALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059
            N LGD GV + C+ L    C L+ L L  M  N  T S L  L+  KP L +
Sbjct: 979  NDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 1030


>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
            sapiens]
          Length = 1036

 Score =  916 bits (2368), Expect = 0.0
 Identities = 504/1072 (47%), Positives = 682/1072 (63%), Gaps = 72/1072 (6%)

Query: 11   CRLSTYLEELEAVELKKFKLYLGT-ATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69
            C+L+ YLE+LE V+LKKFK++L     + G   +P G  EKA  +++A L+I   G E+A
Sbjct: 8    CKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKA 67

Query: 70   WRLALSTFERINRKDLWERGQRE------DLVRDTPPG---GPSSLGNQSTCLLE----V 116
            W +A+  F  INR+DL+E+ +R+      D  R + P       S+  +   LLE    +
Sbjct: 68   WAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRI 127

Query: 117  SLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQL 176
            S+   +KD ++ YR YVR +F+ +EDRNARLGE V+L+ RYTRL L+KEH +  + +Q+L
Sbjct: 128  SICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQEL 187

Query: 177  LDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWAD 236
            L  G+   +T     SPIK+E LF+PD+E  EP  TVV QGAAGIGK++LA K+MLDWA 
Sbjct: 188  LAIGK--TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWAS 245

Query: 237  GKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGF 296
            G L+Q RFDYLFYI+CRE++   T+ S+ DLI SC P+P+ P+ +++R P R+LF++DGF
Sbjct: 246  GTLYQDRFDYLFYIHCREVSL-VTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGF 304

Query: 297  DELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEH 356
            DEL+ +F +  GP C  W++    ++LL+SLIRKKLLPE SLLITTRP ALEKL  LL+H
Sbjct: 305  DELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDH 364

Query: 357  PRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQ 416
            PRHVEILGFSEA+RKEYF+KYF +  QA   F+ +++NE LFTMCF+PLVCW+VCT L+Q
Sbjct: 365  PRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQ 424

Query: 417  QLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILF 476
            Q+E G  L QTS+TTTAVY+ +L SL+QP+ G+       +  GLCSLAADG+WNQKILF
Sbjct: 425  QMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILF 484

Query: 477  EEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAG 536
            EE DLR HGL   DVSAFL MN+FQK+++CE++YSFIH++FQEFFAAMYY+L+E + G  
Sbjct: 485  EESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRT 544

Query: 537  ---------PDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHI 587
                     P +DVT LL  Y   E+ +L    RFLFGL+N+E  S+LEK L  K+S  I
Sbjct: 545  NVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQI 604

Query: 588  KMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEH 647
            +++LL+WI+ KA++    +Q   LE F CLYE+QEE+F+Q+A+ +F  I + N++++M+H
Sbjct: 605  RLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEI-NLSTRMDH 663

Query: 648  MVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAA 707
            MVSSFC++ C   + L L G  ++   E+      G H  +VQ                 
Sbjct: 664  MVSSFCIENCHRVESLSL-GFLHNMPKEEEEEEKEGRHLDMVQ----------------- 705

Query: 708  ALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALI 767
              C  P+        +A  S G                   L    ++SS C  L + L 
Sbjct: 706  --CVLPSS------SHAACSHG-------------------LVNSHLTSSFCRGLFSVLS 738

Query: 768  ANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNP 827
             +++LT +DLS N +G PGM +LCE L+HP C ++ + L +C L    C +++ VL +N 
Sbjct: 739  TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798

Query: 828  HLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLR 887
             LVELDL+ NAL D G+RLLC GL+H +C L+ LWL  C LT+A C +LAS LS + SL 
Sbjct: 799  KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858

Query: 888  ELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELD 947
             L +  N LGD GV +LCE  ++P C LQ L L    L S  C  LS VL  N NL  L 
Sbjct: 859  RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 918

Query: 948  LSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTN 1007
            L  N LGD G+ LL EGL HP C+LQ L LD+C LT+  C +L   L  +Q+L  L L N
Sbjct: 919  LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGN 978

Query: 1008 NALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059
            N LGD GV + C+ L    C L+ L L  M  N  T S L  L+  KP L +
Sbjct: 979  NDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 1030


>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
           sapiens]
          Length = 979

 Score =  866 bits (2238), Expect = 0.0
 Identities = 469/990 (47%), Positives = 641/990 (64%), Gaps = 72/990 (7%)

Query: 11  CRLSTYLEELEAVELKKFKLYLGT-ATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69
           C+L+ YLE+LE V+LKKFK++L     + G   +P G  EKA  +++A L+I   G E+A
Sbjct: 8   CKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKA 67

Query: 70  WRLALSTFERINRKDLWERGQRE------DLVRDTPPG---GPSSLGNQSTCLLE----V 116
           W +A+  F  INR+DL+E+ +R+      D  R + P       S+  +   LLE    +
Sbjct: 68  WAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRI 127

Query: 117 SLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQL 176
           S+   +KD ++ YR YVR +F+ +EDRNARLGE V+L+ RYTRL L+KEH +  + +Q+L
Sbjct: 128 SICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQEL 187

Query: 177 LDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWAD 236
           L  G+   +T     SPIK+E LF+PD+E  EP  TVV QGAAGIGK++LA K+MLDWA 
Sbjct: 188 LAIGK--TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWAS 245

Query: 237 GKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGF 296
           G L+Q RFDYLFYI+CRE++   T+ S+ DLI SC P+P+ P+ +++R P R+LF++DGF
Sbjct: 246 GTLYQDRFDYLFYIHCREVSL-VTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGF 304

Query: 297 DELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEH 356
           DEL+ +F +  GP C  W++    ++LL+SLIRKKLLPE SLLITTRP ALEKL  LL+H
Sbjct: 305 DELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDH 364

Query: 357 PRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQ 416
           PRHVEILGFSEA+RKEYF+KYF +  QA   F+ +++NE LFTMCF+PLVCW+VCT L+Q
Sbjct: 365 PRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQ 424

Query: 417 QLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILF 476
           Q+E G  L QTS+TTTAVY+ +L SL+QP+ G+       +  GLCSLAADG+WNQKILF
Sbjct: 425 QMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILF 484

Query: 477 EEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAG 536
           EE DLR HGL   DVSAFL MN+FQK+++CE++YSFIH++FQEFFAAMYY+L+E + G  
Sbjct: 485 EESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRT 544

Query: 537 ---------PDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHI 587
                    P +DVT LL  Y   E+ +L    RFLFGL+N+E  S+LEK L  K+S  I
Sbjct: 545 NVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQI 604

Query: 588 KMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEH 647
           +++LL+WI+ KA++    +Q   LE F CLYE+QEE+F+Q+A+ +F  I + N++++M+H
Sbjct: 605 RLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEI-NLSTRMDH 663

Query: 648 MVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAA 707
           MVSSFC++ C   + L L G  ++   E+      G H  +VQ                 
Sbjct: 664 MVSSFCIENCHRVESLSL-GFLHNMPKEEEEEEKEGRHLDMVQ----------------- 705

Query: 708 ALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALI 767
             C  P+        +A  S G                   L    ++SS C  L + L 
Sbjct: 706 --CVLPSS------SHAACSHG-------------------LVNSHLTSSFCRGLFSVLS 738

Query: 768 ANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNP 827
            +++LT +DLS N +G PGM +LCE L+HP C ++ + L +C L    C +++ VL +N 
Sbjct: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798

Query: 828 HLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLR 887
            LVELDL+ NAL D G+RLLC GL+H +C L+ LWL    LT+  C  L+S LS NQ+L 
Sbjct: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLT 858

Query: 888 ELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELD 947
            L L  N LGD G+ LLCEGL HP CKLQ L L  C L S  C  LS +L ++ +LR+L 
Sbjct: 859 HLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLS 918

Query: 948 LSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977
           L  NDLGD G+ +  E L+  +C LQ L L
Sbjct: 919 LGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948



 Score =  204 bits (519), Expect = 4e-52
 Identities = 129/321 (40%), Positives = 166/321 (51%), Gaps = 10/321 (3%)

Query: 746  NLRLKRCRISSSAC-------EDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQ 798
            NL  +   + SS C       E LS   + N      +    G     +  +     H  
Sbjct: 656  NLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAA 715

Query: 799  CRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRL 858
            C   ++      L S  C+ + SVL T+  L ELDL+ N+L D G+R+LC+ L+HP C +
Sbjct: 716  CSHGLVN---SHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNI 772

Query: 859  RTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTL 918
            R LWL  C L+   C +++  LS NQ L ELDLS N LGD G+ LLC GL+H  C L+ L
Sbjct: 773  RRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKL 832

Query: 919  RLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLD 978
             L    L S  C  LS VL  N NL  L L  N LGD G+ LL EGL HP C+LQ L LD
Sbjct: 833  WLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELD 892

Query: 979  SCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMD 1038
            +C LT+  C +L   L  +Q+L  L L NN LGD GV + C+ L    C L+ L L  M 
Sbjct: 893  NCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMY 952

Query: 1039 LNKMTHSRLAALRVTKPYLDI 1059
             N  T S L  L+  KP L +
Sbjct: 953  FNYETKSALETLQEEKPELTV 973


>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
           sapiens]
          Length = 979

 Score =  857 bits (2215), Expect = 0.0
 Identities = 456/946 (48%), Positives = 634/946 (67%), Gaps = 41/946 (4%)

Query: 11  CRLSTYLEELEAVELKKFKLYLGT-ATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69
           C+L+ YLE+LE V+LKKFK++L     + G   +P G  EKA  +++A L+I   G E+A
Sbjct: 8   CKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKA 67

Query: 70  WRLALSTFERINRKDLWERGQRE------DLVRDTPPG---GPSSLGNQSTCLLE----V 116
           W +A+  F  INR+DL+E+ +R+      D  R + P       S+  +   LLE    +
Sbjct: 68  WAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRI 127

Query: 117 SLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQL 176
           S+   +KD ++ YR YVR +F+ +EDRNARLGE V+L+ RYTRL L+KEH +  + +Q+L
Sbjct: 128 SICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQEL 187

Query: 177 LDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWAD 236
           L  G+   +T     SPIK+E LF+PD+E  EP  TVV QGAAGIGK++LA K+MLDWA 
Sbjct: 188 LAIGK--TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWAS 245

Query: 237 GKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGF 296
           G L+Q RFDYLFYI+CRE++   T+ S+ DLI SC P+P+ P+ +++R P R+LF++DGF
Sbjct: 246 GTLYQDRFDYLFYIHCREVSL-VTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGF 304

Query: 297 DELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEH 356
           DEL+ +F +  GP C  W++    ++LL+SLIRKKLLPE SLLITTRP ALEKL  LL+H
Sbjct: 305 DELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDH 364

Query: 357 PRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQ 416
           PRHVEILGFSEA+RKEYF+KYF +  QA   F+ +++NE LFTMCF+PLVCW+VCT L+Q
Sbjct: 365 PRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQ 424

Query: 417 QLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILF 476
           Q+E G  L QTS+TTTAVY+ +L SL+QP+ G+       +  GLCSLAADG+WNQKILF
Sbjct: 425 QMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILF 484

Query: 477 EEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAG 536
           EE DLR HGL   DVSAFL MN+FQK+++CE++YSFIH++FQEFFAAMYY+L+E + G  
Sbjct: 485 EESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRT 544

Query: 537 ---------PDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHI 587
                    P +DVT LL  Y   E+ +L    RFLFGL+N+E  S+LEK L  K+S  I
Sbjct: 545 NVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQI 604

Query: 588 KMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEH 647
           +++LL+WI+ KA++    +Q   LE F CLYE+QEE+F+Q+A+ +F  I + N++++M+H
Sbjct: 605 RLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEI-NLSTRMDH 663

Query: 648 MVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQ--LPE-----------R 694
           MVSSFC++ C   + L L G  ++   E+      G H  +VQ  LP            R
Sbjct: 664 MVSSFCIENCHRVESLSL-GFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGR 722

Query: 695 TVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRI 754
             L       ++  L +N  L+EL L  NALG  G++LLC GL+H  C L+ L L  C +
Sbjct: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 782

Query: 755 SSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESG 814
           +S+ C+DL++ L  + +LTR+ +  N +G  G+ +LCE  ++PQC LQ + L    L S 
Sbjct: 783 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 842

Query: 815 ACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACD 874
            C  ++SVL TN +L  L L GN L D G++LLC+GL HP C+L+ L L  C LT+  C 
Sbjct: 843 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 902

Query: 875 ELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 920
           +L++ L+ +QSLR+L L  N+LGDLGV++ CE L+  +C LQ L L
Sbjct: 903 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948



 Score =  211 bits (537), Expect = 3e-54
 Identities = 120/254 (47%), Positives = 149/254 (58%)

Query: 806  LRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKI 865
            L +C L    C +++ VL +N  LVELDL+ NAL D G+RLLC GL+H +C L+ LWL  
Sbjct: 720  LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779

Query: 866  CRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRL 925
            C LT+A C +LAS LS + SL  L +  N LGD GV +LCE  ++P C LQ L L    L
Sbjct: 780  CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839

Query: 926  GSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAK 985
             S  C  LS VL  N NL  L L  N LGD G+ LL EGL HP C+LQ L LD+C LT+ 
Sbjct: 840  TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899

Query: 986  ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHS 1045
             C +L   L  +Q+L  L L NN LGD GV + C+ L    C L+ L L  M  N  T S
Sbjct: 900  CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959

Query: 1046 RLAALRVTKPYLDI 1059
             L  L+  KP L +
Sbjct: 960  ALETLQEEKPELTV 973


>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
           sapiens]
          Length = 922

 Score =  811 bits (2094), Expect = 0.0
 Identities = 440/933 (47%), Positives = 606/933 (64%), Gaps = 72/933 (7%)

Query: 11  CRLSTYLEELEAVELKKFKLYLGT-ATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69
           C+L+ YLE+LE V+LKKFK++L     + G   +P G  EKA  +++A L+I   G E+A
Sbjct: 8   CKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKA 67

Query: 70  WRLALSTFERINRKDLWERGQRE------DLVRDTPPG---GPSSLGNQSTCLLE----V 116
           W +A+  F  INR+DL+E+ +R+      D  R + P       S+  +   LLE    +
Sbjct: 68  WAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRI 127

Query: 117 SLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQL 176
           S+   +KD ++ YR YVR +F+ +EDRNARLGE V+L+ RYTRL L+KEH +  + +Q+L
Sbjct: 128 SICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQEL 187

Query: 177 LDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWAD 236
           L  G+   +T     SPIK+E LF+PD+E  EP  TVV QGAAGIGK++LA K+MLDWA 
Sbjct: 188 LAIGK--TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWAS 245

Query: 237 GKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGF 296
           G L+Q RFDYLFYI+CRE++   T+ S+ DLI SC P+P+ P+ +++R P R+LF++DGF
Sbjct: 246 GTLYQDRFDYLFYIHCREVSL-VTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGF 304

Query: 297 DELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEH 356
           DEL+ +F +  GP C  W++    ++LL+SLIRKKLLPE SLLITTRP ALEKL  LL+H
Sbjct: 305 DELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDH 364

Query: 357 PRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQ 416
           PRHVEILGFSEA+RKEYF+KYF +  QA   F+ +++NE LFTMCF+PLVCW+VCT L+Q
Sbjct: 365 PRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQ 424

Query: 417 QLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILF 476
           Q+E G  L QTS+TTTAVY+ +L SL+QP+ G+       +  GLCSLAADG+WNQKILF
Sbjct: 425 QMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILF 484

Query: 477 EEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAG 536
           EE DLR HGL   DVSAFL MN+FQK+++CE++YSFIH++FQEFFAAMYY+L+E + G  
Sbjct: 485 EESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRT 544

Query: 537 ---------PDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHI 587
                    P +DVT LL  Y   E+ +L    RFLFGL+N+E  S+LEK L  K+S  I
Sbjct: 545 NVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQI 604

Query: 588 KMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEH 647
           +++LL+WI+ KA++    +Q   LE F CLYE+QEE+F+Q+A+ +F  I + N++++M+H
Sbjct: 605 RLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEI-NLSTRMDH 663

Query: 648 MVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAA 707
           MVSSFC++ C   + L L G  ++   E+      G H  +VQ                 
Sbjct: 664 MVSSFCIENCHRVESLSL-GFLHNMPKEEEEEEKEGRHLDMVQ----------------- 705

Query: 708 ALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALI 767
             C  P+        +A  S G                   L RC +S   C D+S  L 
Sbjct: 706 --CVLPSS------SHAACSHG-------------------LGRCGLSHECCFDISLVLS 738

Query: 768 ANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNP 827
           +N+ L  +DLS N +G  G+ LLC GL+H  C L+ + L    L S  C  ++SVL TN 
Sbjct: 739 SNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQ 798

Query: 828 HLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLR 887
           +L  L L GN L D G++LLC+GL HP C+L+ L L  C LT+  C +L++ L+ +QSLR
Sbjct: 799 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 858

Query: 888 ELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 920
           +L L  N+LGDLGV++ CE L+  +C LQ L L
Sbjct: 859 KLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 891



 Score =  161 bits (407), Expect = 3e-39
 Identities = 85/172 (49%), Positives = 108/172 (62%)

Query: 806 LRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKI 865
           L +C L    C +++ VL +N  LVELDL+ NAL D G+RLLC GL+H +C L+ LWL  
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779

Query: 866 CRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRL 925
             LT+  C  L+S LS NQ+L  L L  N LGD G+ LLCEGL HP CKLQ L L  C L
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839

Query: 926 GSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977
            S  C  LS +L ++ +LR+L L  NDLGD G+ +  E L+  +C LQ L L
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 891



 Score =  151 bits (381), Expect = 4e-36
 Identities = 90/194 (46%), Positives = 109/194 (56%)

Query: 866  CRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRL 925
            C L+   C +++  LS NQ L ELDLS N LGD G+ LLC GL+H  C L+ L L    L
Sbjct: 723  CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGL 782

Query: 926  GSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAK 985
             S  C  LS VL  N NL  L L  N LGD G+ LL EGL HP C+LQ L LD+C LT+ 
Sbjct: 783  TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 842

Query: 986  ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHS 1045
             C +L   L  +Q+L  L L NN LGD GV + C+ L    C L+ L L  M  N  T S
Sbjct: 843  CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 902

Query: 1046 RLAALRVTKPYLDI 1059
             L  L+  KP L +
Sbjct: 903  ALETLQEEKPELTV 916



 Score =  118 bits (296), Expect = 3e-26
 Identities = 62/120 (51%), Positives = 76/120 (63%)

Query: 920  LGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDS 979
            LG C L    C  +S+VL +N  L ELDLS N LGD+G+ LL  GL+H  C L+KLWL +
Sbjct: 720  LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779

Query: 980  CGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDL 1039
             GLT+  C  L   L  NQ LT LYL  N LGD G++LLC+ L HP CKL+VL L   +L
Sbjct: 780  SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 36/91 (39%), Positives = 49/91 (53%), Gaps = 3/91 (3%)

Query: 967  HPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPG 1026
            H AC      L  CGL+ + C ++   L  NQ L +L L++NALGD G+RLLC  L H  
Sbjct: 713  HAAC---SHGLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLL 769

Query: 1027 CKLRVLWLFGMDLNKMTHSRLAALRVTKPYL 1057
            C L+ LWL    L  +  S L+++  T   L
Sbjct: 770  CNLKKLWLVNSGLTSVCCSALSSVLSTNQNL 800


>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
          Length = 1093

 Score =  672 bits (1733), Expect = 0.0
 Identities = 411/1101 (37%), Positives = 594/1101 (53%), Gaps = 94/1101 (8%)

Query: 13   LSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRL 72
            L  YLEEL   EL  FKL+L    E   G  PW  ++KA   ++A L+  ++  E+AW +
Sbjct: 15   LLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAWSV 74

Query: 73   ALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDY 132
            +L  F ++N KDL ER  +E++       GP       T   + +++    +    YR+ 
Sbjct: 75   SLKIFGKMNLKDLCERA-KEEINWSAQTIGPDDAKAGETQEDQEAVLGDGTE----YRNR 129

Query: 133  VRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQAS 192
            ++ KF +  D+ +  G+  +  H               +  ++LL               
Sbjct: 130  IKEKFCITWDKKSLAGKPEDFHHGIA------------EKDRKLL--------------- 162

Query: 193  PIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINC 252
                E LF+ D +    P+ VV+QGAAG+GK+ L  K MLDWA+G L+Q RF Y+FY+N 
Sbjct: 163  ----EHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNG 218

Query: 253  REMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCL 312
            RE+NQ   E S   LI   WP    P++E++  P  LLFIID FDEL  +F +P+   C 
Sbjct: 219  REINQ-LKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCE 277

Query: 313  CWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKE 372
             W ++ P   L++SL+RK +LPE SLL+TTR T  ++L +LL++  +VE+LG SE  R+E
Sbjct: 278  DWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREE 337

Query: 373  YFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTT 432
            Y Y++F +   A +VF+ ++ NE LF+MC VPLVCW  CTCL+QQ+E GG +  T +TTT
Sbjct: 338  YIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTT 397

Query: 433  AVYMLYLLSLMQPKPG-APRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDV 491
            A++  Y+ SL  P  G +P L      R LC +AA G+W    +F  ++LR+ GL   DV
Sbjct: 398  ALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDV 457

Query: 492  SAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYIL----DEGEGGAGPDQDVTRLLTE 547
            S+F++ NI QKD   E  Y F HL  QEFFAAM+Y+L    + G     P +D+  LL  
Sbjct: 458  SSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQS 517

Query: 548  YAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQ 607
             ++ +   L     FLFGLLNE+    LE++   K+S  IK  LLQ ++    SD S  Q
Sbjct: 518  TSYKD-PHLTQMKCFLFGLLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQ 576

Query: 608  QGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYG 667
             G LE F CLYE Q++ FI QA+  F  + + NI  K+  +VSSFCLK CR  + + L  
Sbjct: 577  LGFLELFHCLYETQDKAFISQAMRCFPKVAI-NICEKIHLLVSSFCLKHCRCLRTIRLSV 635

Query: 668  A-------------TYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHL--------- 705
                          T + DG+    C     ++L    E    LD Y  +L         
Sbjct: 636  TVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVL-HTNEHLRELDLYHSNLDKSAMNILH 694

Query: 706  ---------------------------AAALCTNPNLIELSLYRNALGSRGVKLLCQGLR 738
                                       + +L  N NL+ L L  + +G  GVK LC+ L+
Sbjct: 695  HELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALK 754

Query: 739  HPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQ 798
            HP CKLQ LRL+ C ++   C ++S ALI +++L  ++LS N +   G+ LLCE LRHP+
Sbjct: 755  HPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPK 814

Query: 799  CRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRL 858
            C L+ + L  C L    C+ ++  L +N  L  L L  N L D G++L+   L+H  C L
Sbjct: 815  CYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTL 874

Query: 859  RTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTL 918
            ++L L+ C  T+ + + L+++L  N+SL  LDL  N L D GV LLC+  RHP+C LQ L
Sbjct: 875  KSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDL 934

Query: 919  RLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLD 978
             L  C L +A C  L+ V+  N NLR LDL  NDL D G+ +L + L++P C +Q+L L+
Sbjct: 935  ELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLE 994

Query: 979  SCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMD 1038
             CGLT+  C++L   L  N+ L  + LT N LG  G+  L K L  P CKL+VL L    
Sbjct: 995  YCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEA 1054

Query: 1039 LNKMTHSRLAALRVTKPYLDI 1059
             ++     L A+ V+ P+L I
Sbjct: 1055 FDEEAQKLLEAVGVSNPHLII 1075


>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
          Length = 991

 Score =  556 bits (1434), Expect = e-158
 Identities = 345/1050 (32%), Positives = 546/1050 (52%), Gaps = 95/1050 (9%)

Query: 16   YLEELEAVELKKFKLYLGTATELGEGK-IPWGSMEKAGPLEMAQLLITHFGPEEAWRLAL 74
            YL+EL   E  KFK  L    E  E K IPW  ++KA   ++A+LL  H+  ++AW + L
Sbjct: 14   YLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTL 73

Query: 75   STFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVR 134
            + F +INRKDLW + Q E                              ++    YR +++
Sbjct: 74   NLFLQINRKDLWTKAQEE-----------------------------MRNKLNPYRKHMK 104

Query: 135  RKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASPI 194
              F+L+ ++      C+++   + +  +  E+       ++L D     AR         
Sbjct: 105  ETFQLIWEKET----CLHVPEHFYKETMKNEY-------KELNDAYTAAARR-------- 145

Query: 195  KIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCRE 254
                             TVV++G  GIGK+ L  KVMLDWA+G L++ RF ++F++N  E
Sbjct: 146  ----------------HTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCE 189

Query: 255  MNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCW 314
            MN  A E S+ +L+   WPE S  ++++   PER+LFI+DGF++LK +    +      W
Sbjct: 190  MNGIA-ETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQ-LKADLSDDW 247

Query: 315  EEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYF 374
             +++P  ++L+SL++KK+LPE SLLI     A++K + +L HP+ +++LGFSE+E+K YF
Sbjct: 248  RQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYF 307

Query: 375  YKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAV 434
              +F    +A +VFN+VRDN PLF +C  P  CW+VCTC++Q+LE G  L   S+ TT +
Sbjct: 308  SYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYL 367

Query: 435  YMLYLLSLMQPKPGAPRLQPPPNQ---RGLCSLAADGLWNQKILFEEQDLRKHGLDGEDV 491
            Y  +L ++   K G+    P  N+   + LC+LAA+G+W    +F   DLR++GL   + 
Sbjct: 368  YASFLTTVF--KAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEG 425

Query: 492  SAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPD-QDVTRLLTEYAF 550
              ++ M + Q+  +C   ++F+HL  QEF AAM+Y+L   +    P    +T+L+     
Sbjct: 426  VMWVGMRLLQRRGDC---FAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVV 482

Query: 551  SERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGS 610
              ++ L     F+FG+  EE  S LE S  + +S  +K ++ Q ++S +Q +        
Sbjct: 483  QPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAF 542

Query: 611  LEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMV-SSFCLKRCRSAQVLHLYGAT 669
             E F  L+E QE+EF+ + ++ F+ + +      +EH+V +SFCLK C+    L +    
Sbjct: 543  QELFIGLFETQEKEFVTKVMNFFEEVFI--YIGNIEHLVIASFCLKHCQHLTTLRMCVEN 600

Query: 670  YSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRG 729
               D      C +  +  LV           Y   L +   TN N   L +   +L    
Sbjct: 601  IFPDDSG---CISDYNEKLV-----------YWRELCSMFITNKNFQILDMENTSLDDPS 646

Query: 730  VKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMML 789
            + +LC+ L  P CKL+ L          +  +L  A++ N +L  + L G  +    +  
Sbjct: 647  LAILCKALAQPVCKLRKLIFTSVYFGHDS--ELFKAVLHNPHLKLLSLYGTSLSQSDIRH 704

Query: 790  LCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQ 849
            LCE L+HP C+++ + L KC + S  C+++ASVL  N  L  L L  N L D G+ LLC+
Sbjct: 705  LCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCE 764

Query: 850  GLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLR 909
             L+H  C L  L L  C LT+ +CD ++  L  ++SL  LDL  N L D GV  LC  L+
Sbjct: 765  ALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALK 824

Query: 910  HPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPA 969
            HP C ++ L L  C L S +C+ ++ VL  N  L+ L L  N++GD G+  L   LQHP 
Sbjct: 825  HPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPH 884

Query: 970  CRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKL 1029
            C+L+ L L +C +T   C+++   L   +TL  L L   AL    V +LC+ LSHP C L
Sbjct: 885  CKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCAL 944

Query: 1030 RVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059
            ++L L     ++ T   L ++    P+L I
Sbjct: 945  QMLGLHKSGFDEETQKILMSVEEKIPHLTI 974


>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
            sapiens]
          Length = 1043

 Score =  519 bits (1337), Expect = e-147
 Identities = 348/1057 (32%), Positives = 541/1057 (51%), Gaps = 68/1057 (6%)

Query: 13   LSTYLEELEAVELKKFKLYLG--------TATELGEGKIPWGSMEKAGPLEMAQLLITHF 64
            L  YL  L+  +L++FKL L         +A +    +IPW ++  A PL ++ LL  HF
Sbjct: 17   LLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEHF 76

Query: 65   GPEEAWRLALSTFERINRKDLWE--RGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPR 122
               +AW++ L  F+ +N   L E  R + ++ V+      P+    +   +LE +    +
Sbjct: 77   PKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQ---EDLEMLEAAAGNMQ 133

Query: 123  ----KDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQ--VQQQL 176
                +DP +   D +       E  N +   C + +     +L   +H    +  ++ +L
Sbjct: 134  TQGCQDPNQEELDELEE-----ETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAEL 188

Query: 177  LDTGRGHARTVGH-------QASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHK 229
            L+T    +    H       +    +++ L +P+  R +  +T+V+ G AG+GK+ LA +
Sbjct: 189  LETWDNISWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQA-QTIVLVGRAGVGKTTLAMQ 247

Query: 230  VMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERL 289
             ML WA+G LFQ RF Y+FY++C ++     E +  +LI   WP+  AP++E +  PE+L
Sbjct: 248  AMLHWANGVLFQQRFSYVFYLSCHKIRYMK-ETTFAELISLDWPDFDAPIEEFMSQPEKL 306

Query: 290  LFIIDGFDELKPSFHDPQ----GPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPT 345
            LFIIDGF+E+  S    +    G  C  W ++ P   +L+SL++K+L+P  +LLIT +  
Sbjct: 307  LFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTW 366

Query: 346  ALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPL 405
             +  L   L +P  V+I GF+  + + YF ++F ++ +  ++   +R NE LF  C  P+
Sbjct: 367  FVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPM 426

Query: 406  VCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQ-RGLCSL 464
            VCW VC+CL+Q       L+  ++TTT++Y  +  +L             P Q R LCSL
Sbjct: 427  VCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSL 486

Query: 465  AADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAM 524
            A +GLW+    F ++D    GL+   + +    NI QK  +C    +F HLSFQEFFAAM
Sbjct: 487  AIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAM 546

Query: 525  YYILDEGEG---GAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCW 581
             ++L+E       +   Q++  LL      + ++      F FGLLN+     LE +L  
Sbjct: 547  SFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHC 606

Query: 582  KVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSH-FQVIVVSN 640
            K+SP +  +LL+W +   +++ ++LQ   L  F CL+E QEE+F ++ L   F+V +  N
Sbjct: 607  KISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDL--N 664

Query: 641  IASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTL-----LVQLPERT 695
            I    E   SSFCLK C+    L L               S  +H L     +++  +  
Sbjct: 665  ILEDEELQASSFCLKHCKRLNKLRL---------------SVSSHILERDLEILETSKFD 709

Query: 696  VLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRIS 755
              + A++  + + L TN NL EL L  + L +  VK LC  L++P CK+Q L  K     
Sbjct: 710  SRMHAWNS-ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVT-P 767

Query: 756  SSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGA 815
                +DL  AL  N  LT ++ S N +G   + L+ + LRH  C L+ + L KC L + +
Sbjct: 768  EWVLQDLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAAS 826

Query: 816  CQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDE 875
            CQ++A  L +  H+  L L  N L+D G++LLC  L HP C L  L L  C+L A AC  
Sbjct: 827  CQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKH 886

Query: 876  LASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSV 935
            L+  L  N+SL  L+LS N L D GV  LCE L  P   LQ+L L  C      C  L+ 
Sbjct: 887  LSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELAN 946

Query: 936  VLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLG 995
             L  NHN++ LDL  NDL D G+ LL E L+ P   L  L L  C LT   C++L+  L 
Sbjct: 947  ALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLS 1005

Query: 996  INQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 1032
             +++L +L L  N L   GV++LCK L    C+L+ L
Sbjct: 1006 SSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042



 Score =  131 bits (330), Expect = 3e-30
 Identities = 87/248 (35%), Positives = 130/248 (52%), Gaps = 2/248 (0%)

Query: 801  LQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRT 860
            L++++  K      A   + S L TN +L ELDL+ + L    ++ LC  L++P C+++ 
Sbjct: 700  LEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQK 759

Query: 861  LWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 920
            L  K          +L   L  N  L  L+ S N+LG + V L+ + LRH  C L+ L L
Sbjct: 760  LTCKSVT-PEWVLQDLIIALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNLKYLCL 817

Query: 921  GICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSC 980
              C L +A+C+ L++ L +  ++  L L FN L D G+ LL   L HP C L++L L  C
Sbjct: 818  EKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFC 877

Query: 981  GLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLN 1040
             L A AC++L   L  N++LT L L+ N+L D GV+ LC+ L  P   L+ L L G    
Sbjct: 878  QLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFT 937

Query: 1041 KMTHSRLA 1048
            +     LA
Sbjct: 938  REGCGELA 945


>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
          Length = 994

 Score =  509 bits (1312), Expect = e-144
 Identities = 337/1011 (33%), Positives = 518/1011 (51%), Gaps = 110/1011 (10%)

Query: 13  LSTYLEELEAVELKKFKLYLGTAT-ELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWR 71
           L  YLEEL+  E +KFK +L   T +L   +IPW  ++KA   E+A LLI H+  ++AW 
Sbjct: 11  LMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWN 70

Query: 72  LALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRD 131
           + L  F++++RKDL  +  RE                             R    +TY+ 
Sbjct: 71  ITLRIFQKMDRKDLCMKVMRE-----------------------------RTGYTKTYQA 101

Query: 132 YVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQA 191
           + ++KF       +RL      S   T + L  E     +V+Q+  D             
Sbjct: 102 HAKQKF-------SRLWS----SKSVTEIHLYFEE----EVKQEECD------------- 133

Query: 192 SPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYIN 251
               ++ LF P +E  + PRTV++QG  GIGK+ L  K+M+ W+D K+F+ RF Y FY  
Sbjct: 134 ---HLDRLFAP-KEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFC 189

Query: 252 CREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWC 311
           CRE+ +     S+ DLI   WP+P+AP+ E++  PERLLF+ID F+EL+   ++P    C
Sbjct: 190 CRELRE-LPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLC 248

Query: 312 LCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERK 371
               EKRP ++LL+SL+RKK+LPE SLLI  +P   ++L   +      +  GF+E++R 
Sbjct: 249 GDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRL 308

Query: 372 EYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTT 431
            YF  +F + ++A + FN VR++E LF++C +PL+CW++CT L+Q+++ G  L  T ++T
Sbjct: 309 VYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQST 368

Query: 432 TAVYMLYLLSLMQPKPG-APRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGED 490
           T+VY  ++ +L  P+    P  Q     + LCSLAA+G+W     F E DLR++G+   D
Sbjct: 369 TSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDAD 428

Query: 491 VSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQDVTR--LLTEY 548
           + A L   I  K    E  Y F+H+  QEF AA++Y+L        P     +  L+  +
Sbjct: 429 IPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANF 488

Query: 549 AFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQ 608
             + R+       FL GLLN++ +  L+    +++S  IK  + Q ++S  +      Q 
Sbjct: 489 EKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQV 548

Query: 609 GSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVL----- 663
            SL  F CL+E+Q+  F++QA++  Q     +I   ++ +VS++CLK C S + L     
Sbjct: 549 DSLAIFYCLFEMQDPAFVKQAVNLLQE-ANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQ 607

Query: 664 --------HLYGATYS---------------------------ADGEDRARCSAGAH--T 686
                   H   + YS                           ++      C+   H   
Sbjct: 608 NVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSC 667

Query: 687 LLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQN 746
            L +L    V     S  L   L   P+L  LS     L    ++ LC  L +P   ++ 
Sbjct: 668 RLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKE 727

Query: 747 LRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQL 806
           L L  C +S   CE L+  L  NK LT +++S N +   G+ LLCE L  P   L  + L
Sbjct: 728 LALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLD-TGVPLLCEALCSPDTVLVYLML 786

Query: 807 RKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKIC 866
             C L    C+ ++ +L  N  +  LDL+ N L+D GL+ LC+ L+HP C L +L L  C
Sbjct: 787 AFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKC 846

Query: 867 RLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLG 926
            +TAA C++LAS L  NQ+L+ L +  NE+GD+GV LLC  L H  C+L+ L L  C L 
Sbjct: 847 FITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLT 906

Query: 927 SAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977
           S  C+ L+ VL  +  L++L+L+ N L   G+ +L E L+HP C LQ L L
Sbjct: 907 STCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGL 957



 Score =  100 bits (249), Expect = 7e-21
 Identities = 50/131 (38%), Positives = 82/131 (62%)

Query: 703 EHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDL 762
           E LA+AL +N NL  L +  N +G  GV+LLC+ L H +C+L+ L L+ C ++S+ C+DL
Sbjct: 854 EDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDL 913

Query: 763 SAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASV 822
           ++ L  +K L +++L+ N +   G+++LCE LRHP+C LQ++ LRK   +      + + 
Sbjct: 914 ASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAE 973

Query: 823 LGTNPHLVELD 833
              NP+L   D
Sbjct: 974 EERNPNLTITD 984



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 35/100 (35%), Positives = 46/100 (46%), Gaps = 3/100 (3%)

Query: 680 CSAGAHT---LLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQG 736
           C A  HT   L +   E   L     + LA+ L  +  L +L+L  N L   GV +LC+ 
Sbjct: 885 CRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEA 944

Query: 737 LRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMD 776
           LRHP C LQ L L++          L+A    N NLT  D
Sbjct: 945 LRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITD 984


>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
          Length = 1200

 Score =  494 bits (1273), Expect = e-139
 Identities = 344/1053 (32%), Positives = 522/1053 (49%), Gaps = 55/1053 (5%)

Query: 17   LEELEAVELKKFK-LYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRLALS 75
            L EL+  E + FK L    ++E     IP   +E A    +A LL  ++G   AW  ++S
Sbjct: 69   LYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWATSIS 128

Query: 76   TFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTP--RKDPQETYRDYV 133
             FE +N + L E+  R+D+ R +P    +++ +Q     +V  ++   ++D         
Sbjct: 129  IFENMNLRTLSEKA-RDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAETKE 187

Query: 134  RRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASP 193
            +   + ME   A   E      +     + +E +   + ++Q      GH        S 
Sbjct: 188  QEISQAMEQEGATAAET---EEQEISQAMEQEGATAAETEEQ------GHGGDTWDYKSH 238

Query: 194  IKIETLFEPDEER---------PEP---------------PRTVVMQGAAGIGKSMLAHK 229
            +  +   E D  R         PE                PRTVV+ G +GIGKS LA +
Sbjct: 239  VMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARR 298

Query: 230  VMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERL 289
            ++L WA G L+QG F Y+F++  REM Q   E S+ + I   WP+  AP+ E++  PERL
Sbjct: 299  IVLCWAQGGLYQGMFSYVFFLPVREM-QRKKESSVTEFISREWPDSQAPVTEIMSRPERL 357

Query: 290  LFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEK 349
            LFIIDGFD+L    ++     C  W EK+P   L+ SL+RK LLPE  L++T R    EK
Sbjct: 358  LFIIDGFDDLGSVLNNDT-KLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEK 416

Query: 350  LHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWV 409
            L   +  PR++ + G S  +R     +      Q  Q    + +N  L   C VP V  +
Sbjct: 417  LKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSL 476

Query: 410  VCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPR---LQPPPNQRGLCSLAA 466
            +C  LQ Q   G  +   ++T T ++  ++   + P+    R   L+     +  C +A 
Sbjct: 477  ICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAV 536

Query: 467  DGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYY 526
            +G+WN+K +F+  DL   GL   ++ A  +MNI   D +CE YY+F HLS Q+F AA+YY
Sbjct: 537  EGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYY 596

Query: 527  ILD--EGEGGAGPDQDVTRLLTEYAFSERSF---LALTSRFLFGLLNEETRSHLEKSLCW 581
            +L+  E E    P   V +        +  F        RFLFGL++E+ R  LE  L  
Sbjct: 597  VLEGLEIEPALCP-LYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLEVLLGC 655

Query: 582  KVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNI 641
             V   +K  LL W+    Q   +T    +L+ F CL+E Q++EF++ AL+ FQ + +  I
Sbjct: 656  PVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLP-I 714

Query: 642  ASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAY 701
               ++ + SSFCL+ C   + + +         E    C      + + + ++T L++  
Sbjct: 715  NQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACP----VVPLWMRDKT-LIEEQ 769

Query: 702  SEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACED 761
             E   + L T+P+L +L L  + L  R +K LC  LRHP CK+Q L  +  +I+    + 
Sbjct: 770  WEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGV-QH 828

Query: 762  LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 821
            L   ++AN+NL  ++L G  +    + + CE L+HP+C L+ ++L  C L      +++ 
Sbjct: 829  LWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQ 888

Query: 822  VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 881
            +L T+P L  L L GN + D G+  L   LR   C L+ L L+ C +TA  C  LAS L 
Sbjct: 889  ILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALV 948

Query: 882  VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANH 941
             N+SL  L LS N LG+ GV LLC  +R P C LQ L L  C L +A C  L++ L  N 
Sbjct: 949  SNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNS 1008

Query: 942  NLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLT 1001
             L  L LS N + D G+ LL E ++ P+C LQ L L  C LTA  CE+L   +  ++ L 
Sbjct: 1009 WLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLK 1068

Query: 1002 DLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 1034
             L LT+NALGD GV  LC+ L      L  L L
Sbjct: 1069 SLDLTDNALGDGGVAALCEGLKQKNSVLARLGL 1101



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 47/114 (41%), Positives = 60/114 (52%)

Query: 697  LLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISS 756
            L  A  E L+  +  + +L  L L  NALG  GV  LC+GL+  N  L  L LK C ++S
Sbjct: 1049 LTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTS 1108

Query: 757  SACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQ 810
              CE LS AL  N++LT ++L  N     GMM LC     P   LQ+I L K Q
Sbjct: 1109 DCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQ 1162



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 36/127 (28%), Positives = 61/127 (48%), Gaps = 1/127 (0%)

Query: 931  EGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENL 990
            E    +L  + +LR+LDL  + L +  +  L   L+HP C++Q L   +  +T    ++L
Sbjct: 771  EDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITP-GVQHL 829

Query: 991  YFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAAL 1050
            +  +  N+ L  L L    L +  VR+ C+ L HP C L  L L    L    + +++ +
Sbjct: 830  WRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQI 889

Query: 1051 RVTKPYL 1057
              T P L
Sbjct: 890  LTTSPSL 896


>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
            sapiens]
          Length = 1429

 Score =  492 bits (1267), Expect = e-139
 Identities = 325/813 (39%), Positives = 448/813 (55%), Gaps = 65/813 (7%)

Query: 152  NLSHRYTRLLLVKE----HSNPMQVQQ--QLLDTGRGHARTVGHQASPIKIETLFEPDEE 205
            + + ++T+LLL++       +P+  +     ++  RGH          I+I  LF P  +
Sbjct: 273  DFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHL---------IEIRDLFGPGLD 323

Query: 206  RPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQ 265
              EP R V++QGAAGIGKS LA +V   W  G+L+  RF ++FY +CRE+ QS    S+ 
Sbjct: 324  TQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKV-VSLA 381

Query: 266  DLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLN 325
            +LI        AP+++++  PERLLFI+DG DE      +P    CL W + +P + LL 
Sbjct: 382  ELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLG 441

Query: 326  SLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAG 385
            SL+ K +LPE S LIT R TAL+ L   LE  R VE+LGFSE+ RKEYFY+YF +  QA 
Sbjct: 442  SLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAI 501

Query: 386  QVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQP 445
            + F  V+ N+ L+ +C VP V W+ CTCL QQ++    L  TS+TTT + + YL   +Q 
Sbjct: 502  RAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQA 561

Query: 446  KPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDIN 505
            +P  P+L      R LCSLAA+G+W +K LF   DLRKHGLDG  +S FL M I Q+   
Sbjct: 562  QPLGPQL------RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH-P 614

Query: 506  CERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQ----DVTRLLTEYAFSERSFLALTSR 561
                YSFIHL FQEFFAAM Y+L E E G G       D+ + L  Y      F A T+R
Sbjct: 615  IPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTR 672

Query: 562  FLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQ 621
            FL GLL++E    +E     ++S     +L+QW+ S        LQ  SLE   CLYE +
Sbjct: 673  FLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQ----LLLQPHSLESLHCLYETR 726

Query: 622  EEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCS 681
             + F+ Q ++HF+ + +  + + ME +V +FC+K  R  + L L         E R   S
Sbjct: 727  NKTFLTQVMAHFEEMGMC-VETDMELLVCTFCIKFSRHVKKLQLI--------EGRQHRS 777

Query: 682  AGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPN 741
              + T++V L     + DAY + L + L    NL EL L  N+L    VK LC+ LR P 
Sbjct: 778  TWSPTMVV-LFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPR 836

Query: 742  CKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRL 801
            C L+ LRL  C +++  C+DL+  L AN+ LT +DLS N +   G   LC+ LR P C+L
Sbjct: 837  CLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKL 896

Query: 802  QMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTL 861
            Q +QL  C L S  CQ++ASVL  +P L ELDL  N L+D+G+RLLC+GLRHP C+L  L
Sbjct: 897  QRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956

Query: 862  WLKICRLTAAACDELASTLSVNQSLRELDLSLNEL-----GDLGVLLLCEGLRHPTCKLQ 916
             L          D+   +  + Q LR L+    +L         V+   EGL        
Sbjct: 957  GL----------DQTTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNS 1006

Query: 917  TLRLGICRLGSAACEGLSVVLQANHNLRELDLS 949
            T  L   RLGS      S V QA  NL+ LD+S
Sbjct: 1007 TSSLKRQRLGSE--RAASHVAQA--NLKLLDVS 1035



 Score =  149 bits (376), Expect = 1e-35
 Identities = 85/174 (48%), Positives = 110/174 (63%)

Query: 817 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
           Q + SVL    +L ELDL+GN+L    ++ LC+ LR P C L TL L  C LTA  C +L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857

Query: 877 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936
           A  L  NQ+L ELDLS N L D G   LC+ LR P+CKLQ L+L  C L S  C+ L+ V
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917

Query: 937 LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENL 990
           L A+ +L+ELDL  N+L D G+ LL EGL+HPAC+L +L LD   L+ +  + L
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971



 Score =  145 bits (366), Expect = 2e-34
 Identities = 87/190 (45%), Positives = 110/190 (57%)

Query: 868  LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGS 927
            +T A    L S L V ++L+ELDLS N L    V  LC+ LR P C L+TLRL  C L +
Sbjct: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 928  AACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKAC 987
              C+ L+  L+AN  L ELDLSFN L D G   L + L+ P+C+LQ+L L SCGLT+  C
Sbjct: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 988  ENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRL 1047
            ++L   L  + +L +L L  N L D GVRLLC+ L HP CKL  L L    L+      L
Sbjct: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971

Query: 1048 AALRVTKPYL 1057
             AL   KP L
Sbjct: 972  RALEQEKPQL 981



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 48/165 (29%), Positives = 75/165 (45%), Gaps = 6/165 (3%)

Query: 12  RLSTYLEELEAVELKKFKLYLGTA--TELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69
           RL+ YLE L+  ELK+F+L L     +    G+ P    EK   +E+A  L+  +G + A
Sbjct: 8   RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETP-AQPEKTSGMEVASYLVAQYGEQRA 66

Query: 70  WRLALSTFERINRKDLWERGQREDLVRDTPPGGPSS--LGNQS-TCLLEVSLVTPRKDPQ 126
           W LAL T+E++  + L  + Q       + P  PS   LG+ S      V +    + P 
Sbjct: 67  WDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPWIHELPA 126

Query: 127 ETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQ 171
              +   RR  R + D + R    ++ S  Y  L    +H +P Q
Sbjct: 127 GCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQ 171


>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
            sapiens]
          Length = 1375

 Score =  492 bits (1267), Expect = e-139
 Identities = 325/813 (39%), Positives = 448/813 (55%), Gaps = 65/813 (7%)

Query: 152  NLSHRYTRLLLVKE----HSNPMQVQQ--QLLDTGRGHARTVGHQASPIKIETLFEPDEE 205
            + + ++T+LLL++       +P+  +     ++  RGH          I+I  LF P  +
Sbjct: 273  DFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHL---------IEIRDLFGPGLD 323

Query: 206  RPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQ 265
              EP R V++QGAAGIGKS LA +V   W  G+L+  RF ++FY +CRE+ QS    S+ 
Sbjct: 324  TQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKV-VSLA 381

Query: 266  DLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLN 325
            +LI        AP+++++  PERLLFI+DG DE      +P    CL W + +P + LL 
Sbjct: 382  ELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLG 441

Query: 326  SLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAG 385
            SL+ K +LPE S LIT R TAL+ L   LE  R VE+LGFSE+ RKEYFY+YF +  QA 
Sbjct: 442  SLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAI 501

Query: 386  QVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQP 445
            + F  V+ N+ L+ +C VP V W+ CTCL QQ++    L  TS+TTT + + YL   +Q 
Sbjct: 502  RAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQA 561

Query: 446  KPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDIN 505
            +P  P+L      R LCSLAA+G+W +K LF   DLRKHGLDG  +S FL M I Q+   
Sbjct: 562  QPLGPQL------RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH-P 614

Query: 506  CERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQ----DVTRLLTEYAFSERSFLALTSR 561
                YSFIHL FQEFFAAM Y+L E E G G       D+ + L  Y      F A T+R
Sbjct: 615  IPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTR 672

Query: 562  FLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQ 621
            FL GLL++E    +E     ++S     +L+QW+ S        LQ  SLE   CLYE +
Sbjct: 673  FLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQ----LLLQPHSLESLHCLYETR 726

Query: 622  EEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCS 681
             + F+ Q ++HF+ + +  + + ME +V +FC+K  R  + L L         E R   S
Sbjct: 727  NKTFLTQVMAHFEEMGMC-VETDMELLVCTFCIKFSRHVKKLQLI--------EGRQHRS 777

Query: 682  AGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPN 741
              + T++V L     + DAY + L + L    NL EL L  N+L    VK LC+ LR P 
Sbjct: 778  TWSPTMVV-LFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPR 836

Query: 742  CKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRL 801
            C L+ LRL  C +++  C+DL+  L AN+ LT +DLS N +   G   LC+ LR P C+L
Sbjct: 837  CLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKL 896

Query: 802  QMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTL 861
            Q +QL  C L S  CQ++ASVL  +P L ELDL  N L+D+G+RLLC+GLRHP C+L  L
Sbjct: 897  QRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956

Query: 862  WLKICRLTAAACDELASTLSVNQSLRELDLSLNEL-----GDLGVLLLCEGLRHPTCKLQ 916
             L          D+   +  + Q LR L+    +L         V+   EGL        
Sbjct: 957  GL----------DQTTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNS 1006

Query: 917  TLRLGICRLGSAACEGLSVVLQANHNLRELDLS 949
            T  L   RLGS      S V QA  NL+ LD+S
Sbjct: 1007 TSSLKRQRLGSE--RAASHVAQA--NLKLLDVS 1035



 Score =  149 bits (376), Expect = 1e-35
 Identities = 85/174 (48%), Positives = 110/174 (63%)

Query: 817 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
           Q + SVL    +L ELDL+GN+L    ++ LC+ LR P C L TL L  C LTA  C +L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857

Query: 877 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936
           A  L  NQ+L ELDLS N L D G   LC+ LR P+CKLQ L+L  C L S  C+ L+ V
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917

Query: 937 LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENL 990
           L A+ +L+ELDL  N+L D G+ LL EGL+HPAC+L +L LD   L+ +  + L
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971



 Score =  145 bits (366), Expect = 2e-34
 Identities = 87/190 (45%), Positives = 110/190 (57%)

Query: 868  LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGS 927
            +T A    L S L V ++L+ELDLS N L    V  LC+ LR P C L+TLRL  C L +
Sbjct: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 928  AACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKAC 987
              C+ L+  L+AN  L ELDLSFN L D G   L + L+ P+C+LQ+L L SCGLT+  C
Sbjct: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 988  ENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRL 1047
            ++L   L  + +L +L L  N L D GVRLLC+ L HP CKL  L L    L+      L
Sbjct: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971

Query: 1048 AALRVTKPYL 1057
             AL   KP L
Sbjct: 972  RALEQEKPQL 981



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 48/165 (29%), Positives = 75/165 (45%), Gaps = 6/165 (3%)

Query: 12  RLSTYLEELEAVELKKFKLYLGTA--TELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69
           RL+ YLE L+  ELK+F+L L     +    G+ P    EK   +E+A  L+  +G + A
Sbjct: 8   RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETP-AQPEKTSGMEVASYLVAQYGEQRA 66

Query: 70  WRLALSTFERINRKDLWERGQREDLVRDTPPGGPSS--LGNQS-TCLLEVSLVTPRKDPQ 126
           W LAL T+E++  + L  + Q       + P  PS   LG+ S      V +    + P 
Sbjct: 67  WDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPWIHELPA 126

Query: 127 ETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQ 171
              +   RR  R + D + R    ++ S  Y  L    +H +P Q
Sbjct: 127 GCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQ 171


>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 1473

 Score =  492 bits (1267), Expect = e-139
 Identities = 325/813 (39%), Positives = 448/813 (55%), Gaps = 65/813 (7%)

Query: 152  NLSHRYTRLLLVKE----HSNPMQVQQ--QLLDTGRGHARTVGHQASPIKIETLFEPDEE 205
            + + ++T+LLL++       +P+  +     ++  RGH          I+I  LF P  +
Sbjct: 273  DFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHL---------IEIRDLFGPGLD 323

Query: 206  RPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQ 265
              EP R V++QGAAGIGKS LA +V   W  G+L+  RF ++FY +CRE+ QS    S+ 
Sbjct: 324  TQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKV-VSLA 381

Query: 266  DLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLN 325
            +LI        AP+++++  PERLLFI+DG DE      +P    CL W + +P + LL 
Sbjct: 382  ELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLG 441

Query: 326  SLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAG 385
            SL+ K +LPE S LIT R TAL+ L   LE  R VE+LGFSE+ RKEYFY+YF +  QA 
Sbjct: 442  SLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAI 501

Query: 386  QVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQP 445
            + F  V+ N+ L+ +C VP V W+ CTCL QQ++    L  TS+TTT + + YL   +Q 
Sbjct: 502  RAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQA 561

Query: 446  KPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDIN 505
            +P  P+L      R LCSLAA+G+W +K LF   DLRKHGLDG  +S FL M I Q+   
Sbjct: 562  QPLGPQL------RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH-P 614

Query: 506  CERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQ----DVTRLLTEYAFSERSFLALTSR 561
                YSFIHL FQEFFAAM Y+L E E G G       D+ + L  Y      F A T+R
Sbjct: 615  IPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTR 672

Query: 562  FLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQ 621
            FL GLL++E    +E     ++S     +L+QW+ S        LQ  SLE   CLYE +
Sbjct: 673  FLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQ----LLLQPHSLESLHCLYETR 726

Query: 622  EEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCS 681
             + F+ Q ++HF+ + +  + + ME +V +FC+K  R  + L L         E R   S
Sbjct: 727  NKTFLTQVMAHFEEMGMC-VETDMELLVCTFCIKFSRHVKKLQLI--------EGRQHRS 777

Query: 682  AGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPN 741
              + T++V L     + DAY + L + L    NL EL L  N+L    VK LC+ LR P 
Sbjct: 778  TWSPTMVV-LFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPR 836

Query: 742  CKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRL 801
            C L+ LRL  C +++  C+DL+  L AN+ LT +DLS N +   G   LC+ LR P C+L
Sbjct: 837  CLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKL 896

Query: 802  QMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTL 861
            Q +QL  C L S  CQ++ASVL  +P L ELDL  N L+D+G+RLLC+GLRHP C+L  L
Sbjct: 897  QRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956

Query: 862  WLKICRLTAAACDELASTLSVNQSLRELDLSLNEL-----GDLGVLLLCEGLRHPTCKLQ 916
             L          D+   +  + Q LR L+    +L         V+   EGL        
Sbjct: 957  GL----------DQTTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNS 1006

Query: 917  TLRLGICRLGSAACEGLSVVLQANHNLRELDLS 949
            T  L   RLGS      S V QA  NL+ LD+S
Sbjct: 1007 TSSLKRQRLGSE--RAASHVAQA--NLKLLDVS 1035



 Score =  149 bits (376), Expect = 1e-35
 Identities = 85/174 (48%), Positives = 110/174 (63%)

Query: 817 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
           Q + SVL    +L ELDL+GN+L    ++ LC+ LR P C L TL L  C LTA  C +L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857

Query: 877 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936
           A  L  NQ+L ELDLS N L D G   LC+ LR P+CKLQ L+L  C L S  C+ L+ V
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917

Query: 937 LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENL 990
           L A+ +L+ELDL  N+L D G+ LL EGL+HPAC+L +L LD   L+ +  + L
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971



 Score =  145 bits (366), Expect = 2e-34
 Identities = 87/190 (45%), Positives = 110/190 (57%)

Query: 868  LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGS 927
            +T A    L S L V ++L+ELDLS N L    V  LC+ LR P C L+TLRL  C L +
Sbjct: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 928  AACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKAC 987
              C+ L+  L+AN  L ELDLSFN L D G   L + L+ P+C+LQ+L L SCGLT+  C
Sbjct: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 988  ENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRL 1047
            ++L   L  + +L +L L  N L D GVRLLC+ L HP CKL  L L    L+      L
Sbjct: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971

Query: 1048 AALRVTKPYL 1057
             AL   KP L
Sbjct: 972  RALEQEKPQL 981



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 48/165 (29%), Positives = 75/165 (45%), Gaps = 6/165 (3%)

Query: 12  RLSTYLEELEAVELKKFKLYLGTA--TELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69
           RL+ YLE L+  ELK+F+L L     +    G+ P    EK   +E+A  L+  +G + A
Sbjct: 8   RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETP-AQPEKTSGMEVASYLVAQYGEQRA 66

Query: 70  WRLALSTFERINRKDLWERGQREDLVRDTPPGGPSS--LGNQS-TCLLEVSLVTPRKDPQ 126
           W LAL T+E++  + L  + Q       + P  PS   LG+ S      V +    + P 
Sbjct: 67  WDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPWIHELPA 126

Query: 127 ETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQ 171
              +   RR  R + D + R    ++ S  Y  L    +H +P Q
Sbjct: 127 GCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQ 171


>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
          Length = 1062

 Score =  488 bits (1256), Expect = e-137
 Identities = 354/1071 (33%), Positives = 536/1071 (50%), Gaps = 62/1071 (5%)

Query: 13   LSTYLEELEAVELKKFKLYLGTATELGE-GKIPWGSMEKAGPLEMAQLLITHFGPEEAWR 71
            L   LE+L   EL KFK  + T +   E  KIP   ++KA   ++ ++L TH        
Sbjct: 11   LQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWVEM 70

Query: 72   LALSTFERINRKDLWERGQ---REDLVRDTPPGGPSSLG--NQSTCLLEVSLVTPR-KDP 125
             +L  FE+++R DL ER +   RE  ++      P SLG   +    L+V  +  R K  
Sbjct: 71   ASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDVDEMLERFKTE 130

Query: 126  QETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHAR 185
             + + +       L   +    G+  +  +R   +L  K         +++  +  G ++
Sbjct: 131  AQAFTETKGNVICL--GKEVFKGKKPDKDNRCRYILKTKF--------REMWKSWPGDSK 180

Query: 186  TVGHQASPIKIETLFEPDEERPEP-PRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRF 244
             V   A   K+   F      P P   TVV+ G AG+GK+ LA K+MLDWA+  L   +F
Sbjct: 181  EVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIH-KF 239

Query: 245  DYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFH 304
             Y FY++CRE+++    CS  +L+F  WPE    +  ++    ++LF+IDGFDEL  +  
Sbjct: 240  KYAFYLSCRELSRLGP-CSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAPG 298

Query: 305  DPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILG 364
                  C  WE+K+P  +LL SL+ + +LP+ +LL+TTRP AL  L  L E P ++ + G
Sbjct: 299  ALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEG 358

Query: 365  FSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLL 424
            F E +R+ YF ++F + +QA + F  +R N  LF +   P VCW+VCT L+ Q+E G   
Sbjct: 359  FLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDP 418

Query: 425  RQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKH 484
              T  T T +++ +L S     P   +L+     R L  LAA GLW Q  +   +DL + 
Sbjct: 419  VPTCLTRTGLFLRFLCSRF---PQGAQLRGA--LRTLSLLAAQGLWAQTSVLHREDLERL 473

Query: 485  GLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGE-----GGAGPDQ 539
            G+   D+  FL+ +I ++D   +  YSFIHLSFQ+F  A++Y L++ E     G      
Sbjct: 474  GVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIG 533

Query: 540  DVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQW-IQSK 598
            DV +LL+         L     + FGL NE+    LE +   ++SP IK +LL+  I  K
Sbjct: 534  DVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDISCK 593

Query: 599  AQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCR 658
                  T  Q   E   CLYE QEEE +++ ++ F+ I +    + ++ + SSFC+K CR
Sbjct: 594  GGHSTVTDLQ---ELLGCLYESQEEELVKEVMAQFKEISLH--LNAVDVVPSSFCVKHCR 648

Query: 659  SAQVLHLY--------GATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALC 710
            + Q + L           T S    +  R     H L             +   L +   
Sbjct: 649  NLQKMSLQVIKENLPENVTASESDAEVERSQDDQHML------------PFWTDLCSIFG 696

Query: 711  TNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANK 770
            +N +L+ L++  + L +  V++LC+ +    C LQ +  K     + A  +L  AL  +K
Sbjct: 697  SNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PADAHRNLCLALRGHK 755

Query: 771  NLTRMDLSGNGVG--FPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH 828
             +T + L GN     FP    LCE LRHP+C L+ + L  C   +    +++  L  N  
Sbjct: 756  TVTYLTLQGNDQDDMFPA---LCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQS 812

Query: 829  LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRE 888
            L  ++L+ N L D G +LL   LRHP C L+ L L+ C LT A C +LA+ L V++ L  
Sbjct: 813  LTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTH 872

Query: 889  LDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDL 948
            L L+ N +G+ GV  LCEGLR+P CKLQTL L  C + S  C  L+ +LQ   +L  LDL
Sbjct: 873  LCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDL 932

Query: 949  SFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNN 1008
              N +G  G+  L E L+ P C L+ LWL  C +   +CE+L   L  NQ+L  L L  N
Sbjct: 933  GLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQN 992

Query: 1009 ALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059
             LG +GV++L + L+     LR L L   D N   +  L  +    P L I
Sbjct: 993  PLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLII 1043



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 63/188 (33%), Positives = 89/188 (47%), Gaps = 4/188 (2%)

Query: 875  ELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSA-ACEGL 933
            +L S    N+ L  L ++ + L    V +LCE +   TC LQ  R+    +  A A   L
Sbjct: 690  DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQ--RVVFKNISPADAHRNL 747

Query: 934  SVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFT 993
             + L+ +  +  L L  ND  D     L E L+HP C L+ L L SC  T +   +L   
Sbjct: 748  CLALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLA 806

Query: 994  LGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVT 1053
            L +NQ+LT + L++N L D G +LL   L HP C L+ L L    L +     LAA+ V 
Sbjct: 807  LEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVV 866

Query: 1054 KPYLDIGC 1061
               L   C
Sbjct: 867  SRELTHLC 874


>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
           sapiens]
          Length = 1399

 Score =  488 bits (1255), Expect = e-137
 Identities = 298/717 (41%), Positives = 413/717 (57%), Gaps = 46/717 (6%)

Query: 152 NLSHRYTRLLLVKE----HSNPMQVQQ--QLLDTGRGHARTVGHQASPIKIETLFEPDEE 205
           + + ++T+LLL++       +P+  +     ++  RGH          I+I  LF P  +
Sbjct: 273 DFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHL---------IEIRDLFGPGLD 323

Query: 206 RPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQ 265
             EP R V++QGAAGIGKS LA +V   W  G+L+  RF ++FY +CRE+ QS    S+ 
Sbjct: 324 TQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKV-VSLA 381

Query: 266 DLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLN 325
           +LI        AP+++++  PERLLFI+DG DE      +P    CL W + +P + LL 
Sbjct: 382 ELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLG 441

Query: 326 SLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAG 385
           SL+ K +LPE S LIT R TAL+ L   LE  R VE+LGFSE+ RKEYFY+YF +  QA 
Sbjct: 442 SLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAI 501

Query: 386 QVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQP 445
           + F  V+ N+ L+ +C VP V W+ CTCL QQ++    L  TS+TTT + + YL   +Q 
Sbjct: 502 RAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQA 561

Query: 446 KPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDIN 505
           +P  P+L      R LCSLAA+G+W +K LF   DLRKHGLDG  +S FL M I Q+   
Sbjct: 562 QPLGPQL------RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH-P 614

Query: 506 CERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQ----DVTRLLTEYAFSERSFLALTSR 561
               YSFIHL FQEFFAAM Y+L E E G G       D+ + L  Y      F A T+R
Sbjct: 615 IPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTR 672

Query: 562 FLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQ 621
           FL GLL++E    +E     ++S     +L+QW+ S        LQ  SLE   CLYE +
Sbjct: 673 FLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQ----LLLQPHSLESLHCLYETR 726

Query: 622 EEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCS 681
            + F+ Q ++HF+ + +  + + ME +V +FC+K  R  + L L         E R   S
Sbjct: 727 NKTFLTQVMAHFEEMGMC-VETDMELLVCTFCIKFSRHVKKLQLI--------EGRQHRS 777

Query: 682 AGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPN 741
             + T++V L     + DAY + L + L    NL EL L  N+L    VK LC+ LR P 
Sbjct: 778 TWSPTMVV-LFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPR 836

Query: 742 CKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRL 801
           C L+ LRL  C +++  C+DL+  L AN+ LT +DLS N +   G   LC+ LR P C+L
Sbjct: 837 CLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKL 896

Query: 802 QMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRL 858
           Q +QL  C L S  CQ++ASVL  +P L ELDL  N L+D+G+RLLC+GLRHP C+L
Sbjct: 897 QRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953



 Score =  145 bits (367), Expect = 2e-34
 Identities = 77/160 (48%), Positives = 101/160 (63%), Gaps = 2/160 (1%)

Query: 762 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 821
           L + L   +NL  +DLSGN +    +  LC+ LR P+C L+ ++L  C L +  C+++A 
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859

Query: 822 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 881
            L  N  L ELDL+ N L D G + LCQ LR P C+L+ L L  C LT+  C +LAS LS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919

Query: 882 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLG 921
            + SL+ELDL  N L D+GV LLCEGLRHP CKL  +RLG
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL--IRLG 957



 Score =  145 bits (365), Expect = 3e-34
 Identities = 81/159 (50%), Positives = 103/159 (64%)

Query: 817 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
           Q + SVL    +L ELDL+GN+L    ++ LC+ LR P C L TL L  C LTA  C +L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857

Query: 877 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936
           A  L  NQ+L ELDLS N L D G   LC+ LR P+CKLQ L+L  C L S  C+ L+ V
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917

Query: 937 LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKL 975
           L A+ +L+ELDL  N+L D G+ LL EGL+HPAC+L +L
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956



 Score =  139 bits (349), Expect = 2e-32
 Identities = 78/162 (48%), Positives = 100/162 (61%)

Query: 868  LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGS 927
            +T A    L S L V ++L+ELDLS N L    V  LC+ LR P C L+TLRL  C L +
Sbjct: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 928  AACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKAC 987
              C+ L+  L+AN  L ELDLSFN L D G   L + L+ P+C+LQ+L L SCGLT+  C
Sbjct: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 988  ENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKL 1029
            ++L   L  + +L +L L  N L D GVRLLC+ L HP CKL
Sbjct: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 53/122 (43%), Positives = 69/122 (56%)

Query: 936  VLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLG 995
            VL+   NL+ELDLS N L    +  L + L+ P C L+ L L  CGLTA+ C++L F L 
Sbjct: 803  VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862

Query: 996  INQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKP 1055
             NQTLT+L L+ N L D G + LC+RL  P CKL+ L L    L       LA++    P
Sbjct: 863  ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922

Query: 1056 YL 1057
             L
Sbjct: 923  SL 924



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 48/165 (29%), Positives = 75/165 (45%), Gaps = 6/165 (3%)

Query: 12  RLSTYLEELEAVELKKFKLYLGTA--TELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69
           RL+ YLE L+  ELK+F+L L     +    G+ P    EK   +E+A  L+  +G + A
Sbjct: 8   RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETP-AQPEKTSGMEVASYLVAQYGEQRA 66

Query: 70  WRLALSTFERINRKDLWERGQREDLVRDTPPGGPSS--LGNQS-TCLLEVSLVTPRKDPQ 126
           W LAL T+E++  + L  + Q       + P  PS   LG+ S      V +    + P 
Sbjct: 67  WDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPWIHELPA 126

Query: 127 ETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQ 171
              +   RR  R + D + R    ++ S  Y  L    +H +P Q
Sbjct: 127 GCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQ 171



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 35/98 (35%), Positives = 49/98 (50%), Gaps = 26/98 (26%)

Query: 703  EHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNL--------------- 747
            + LA+ L  +P+L EL L +N L   GV+LLC+GLRHP CKL  L               
Sbjct: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971

Query: 748  -------RLKRCRISSSACEDLSAALIANKNLTRMDLS 778
                    LKR R+ S    + +A+ +A  NL  +D+S
Sbjct: 972  EMSNSTSSLKRQRLGS----ERAASHVAQANLKLLDVS 1005



 Score = 37.4 bits (85), Expect = 0.076
 Identities = 27/84 (32%), Positives = 39/84 (46%), Gaps = 8/84 (9%)

Query: 961  LAEGLQH-----PACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGV 1015
            L EG QH     P   +   W+    +T    + L+  L + + L +L L+ N+L  + V
Sbjct: 769  LIEGRQHRSTWSPTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAV 825

Query: 1016 RLLCKRLSHPGCKLRVLWLFGMDL 1039
            + LCK L  P C L  L L G  L
Sbjct: 826  KSLCKTLRRPRCLLETLRLAGCGL 849


>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
           sapiens]
          Length = 1443

 Score =  488 bits (1255), Expect = e-137
 Identities = 298/717 (41%), Positives = 413/717 (57%), Gaps = 46/717 (6%)

Query: 152 NLSHRYTRLLLVKE----HSNPMQVQQ--QLLDTGRGHARTVGHQASPIKIETLFEPDEE 205
           + + ++T+LLL++       +P+  +     ++  RGH          I+I  LF P  +
Sbjct: 273 DFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHL---------IEIRDLFGPGLD 323

Query: 206 RPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQ 265
             EP R V++QGAAGIGKS LA +V   W  G+L+  RF ++FY +CRE+ QS    S+ 
Sbjct: 324 TQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKV-VSLA 381

Query: 266 DLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLN 325
           +LI        AP+++++  PERLLFI+DG DE      +P    CL W + +P + LL 
Sbjct: 382 ELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLG 441

Query: 326 SLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAG 385
           SL+ K +LPE S LIT R TAL+ L   LE  R VE+LGFSE+ RKEYFY+YF +  QA 
Sbjct: 442 SLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAI 501

Query: 386 QVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQP 445
           + F  V+ N+ L+ +C VP V W+ CTCL QQ++    L  TS+TTT + + YL   +Q 
Sbjct: 502 RAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQA 561

Query: 446 KPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDIN 505
           +P  P+L      R LCSLAA+G+W +K LF   DLRKHGLDG  +S FL M I Q+   
Sbjct: 562 QPLGPQL------RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH-P 614

Query: 506 CERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQ----DVTRLLTEYAFSERSFLALTSR 561
               YSFIHL FQEFFAAM Y+L E E G G       D+ + L  Y      F A T+R
Sbjct: 615 IPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTR 672

Query: 562 FLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQ 621
           FL GLL++E    +E     ++S     +L+QW+ S        LQ  SLE   CLYE +
Sbjct: 673 FLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQ----LLLQPHSLESLHCLYETR 726

Query: 622 EEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCS 681
            + F+ Q ++HF+ + +  + + ME +V +FC+K  R  + L L         E R   S
Sbjct: 727 NKTFLTQVMAHFEEMGMC-VETDMELLVCTFCIKFSRHVKKLQLI--------EGRQHRS 777

Query: 682 AGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPN 741
             + T++V L     + DAY + L + L    NL EL L  N+L    VK LC+ LR P 
Sbjct: 778 TWSPTMVV-LFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPR 836

Query: 742 CKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRL 801
           C L+ LRL  C +++  C+DL+  L AN+ LT +DLS N +   G   LC+ LR P C+L
Sbjct: 837 CLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKL 896

Query: 802 QMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRL 858
           Q +QL  C L S  CQ++ASVL  +P L ELDL  N L+D+G+RLLC+GLRHP C+L
Sbjct: 897 QRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953



 Score =  145 bits (367), Expect = 2e-34
 Identities = 77/160 (48%), Positives = 101/160 (63%), Gaps = 2/160 (1%)

Query: 762 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 821
           L + L   +NL  +DLSGN +    +  LC+ LR P+C L+ ++L  C L +  C+++A 
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859

Query: 822 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 881
            L  N  L ELDL+ N L D G + LCQ LR P C+L+ L L  C LT+  C +LAS LS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919

Query: 882 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLG 921
            + SL+ELDL  N L D+GV LLCEGLRHP CKL  +RLG
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL--IRLG 957



 Score =  145 bits (365), Expect = 3e-34
 Identities = 81/159 (50%), Positives = 103/159 (64%)

Query: 817 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
           Q + SVL    +L ELDL+GN+L    ++ LC+ LR P C L TL L  C LTA  C +L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857

Query: 877 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936
           A  L  NQ+L ELDLS N L D G   LC+ LR P+CKLQ L+L  C L S  C+ L+ V
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917

Query: 937 LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKL 975
           L A+ +L+ELDL  N+L D G+ LL EGL+HPAC+L +L
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956



 Score =  139 bits (349), Expect = 2e-32
 Identities = 78/162 (48%), Positives = 100/162 (61%)

Query: 868  LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGS 927
            +T A    L S L V ++L+ELDLS N L    V  LC+ LR P C L+TLRL  C L +
Sbjct: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 928  AACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKAC 987
              C+ L+  L+AN  L ELDLSFN L D G   L + L+ P+C+LQ+L L SCGLT+  C
Sbjct: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 988  ENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKL 1029
            ++L   L  + +L +L L  N L D GVRLLC+ L HP CKL
Sbjct: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 53/122 (43%), Positives = 69/122 (56%)

Query: 936  VLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLG 995
            VL+   NL+ELDLS N L    +  L + L+ P C L+ L L  CGLTA+ C++L F L 
Sbjct: 803  VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862

Query: 996  INQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKP 1055
             NQTLT+L L+ N L D G + LC+RL  P CKL+ L L    L       LA++    P
Sbjct: 863  ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922

Query: 1056 YL 1057
             L
Sbjct: 923  SL 924



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 48/165 (29%), Positives = 75/165 (45%), Gaps = 6/165 (3%)

Query: 12  RLSTYLEELEAVELKKFKLYLGTA--TELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69
           RL+ YLE L+  ELK+F+L L     +    G+ P    EK   +E+A  L+  +G + A
Sbjct: 8   RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETP-AQPEKTSGMEVASYLVAQYGEQRA 66

Query: 70  WRLALSTFERINRKDLWERGQREDLVRDTPPGGPSS--LGNQS-TCLLEVSLVTPRKDPQ 126
           W LAL T+E++  + L  + Q       + P  PS   LG+ S      V +    + P 
Sbjct: 67  WDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPWIHELPA 126

Query: 127 ETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQ 171
              +   RR  R + D + R    ++ S  Y  L    +H +P Q
Sbjct: 127 GCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQ 171



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 35/98 (35%), Positives = 49/98 (50%), Gaps = 26/98 (26%)

Query: 703  EHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNL--------------- 747
            + LA+ L  +P+L EL L +N L   GV+LLC+GLRHP CKL  L               
Sbjct: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971

Query: 748  -------RLKRCRISSSACEDLSAALIANKNLTRMDLS 778
                    LKR R+ S    + +A+ +A  NL  +D+S
Sbjct: 972  EMSNSTSSLKRQRLGS----ERAASHVAQANLKLLDVS 1005



 Score = 37.4 bits (85), Expect = 0.076
 Identities = 27/84 (32%), Positives = 39/84 (46%), Gaps = 8/84 (9%)

Query: 961  LAEGLQH-----PACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGV 1015
            L EG QH     P   +   W+    +T    + L+  L + + L +L L+ N+L  + V
Sbjct: 769  LIEGRQHRSTWSPTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAV 825

Query: 1016 RLLCKRLSHPGCKLRVLWLFGMDL 1039
            + LCK L  P C L  L L G  L
Sbjct: 826  KSLCKTLRRPRCLLETLRLAGCGL 849


>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
          Length = 1048

 Score =  463 bits (1191), Expect = e-130
 Identities = 336/1018 (33%), Positives = 509/1018 (50%), Gaps = 65/1018 (6%)

Query: 16   YLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRLALS 75
            Y+  +   EL++FK  L T    G   I W  +E A   E+  LLI  F    AW +  +
Sbjct: 44   YMRNVSHEELQRFKQLLLTELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTSN 103

Query: 76   TFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRR 135
             F  +N   +    +RE                       ++ + P  +P++   +    
Sbjct: 104  IFAIMNCDKMCVVVRRE-----------------------INAILPTLEPEDL--NVGET 138

Query: 136  KFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLD--TGRGHARTVGHQASP 193
            +  L E  + ++        RY         SN M+    + D  T  G+ R   +Q   
Sbjct: 139  QVNLEEGESGKI-------RRYK--------SNVMEKFFPIWDITTWPGNQRDFFYQGVH 183

Query: 194  IKIE---TLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYI 250
               E    L  P   +   P+TV +QGA GIGK++LA KVM +WA  K +  +    FY 
Sbjct: 184  RHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYF 243

Query: 251  NCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPW 310
            +C+E+NQ+ T+ S  +LI   WP     + +++  P++LL ++DGF+EL  +  D     
Sbjct: 244  HCQEVNQT-TDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDL 302

Query: 311  CLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAER 370
               W +K P  +LL+SL+ K +LPE +LLI  R T+ +    LL+ P  V + GF+  E+
Sbjct: 303  SEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEK 362

Query: 371  KEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRT 430
             +YF  YF + E+  QV ++  +N  LF+MC VP+VCW+VC+ L+QQ+E G  L Q+   
Sbjct: 363  IKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPN 422

Query: 431  TTAVYMLYLLSLMQPK-PGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGE 489
             T+V++ Y+ SL   +     R        GLC LAAD +W++K +  ++DL +  LD  
Sbjct: 423  ATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQT 482

Query: 490  DVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAG----PDQDVTRLL 545
             V+AFL M+I ++    E +Y F  ++FQEFFAA++Y+L   +           ++ RL+
Sbjct: 483  GVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQRLI 542

Query: 546  TEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGST 605
                 S +S+L+    FLFG LNE   S +E+S   KVS   K  LL+ I    + D  +
Sbjct: 543  ASPRGS-KSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPS 601

Query: 606  LQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHL 665
               G  + F CL+EI+EE F+ QAL+ +  +V+  I +  E  VS+FCLKRC   Q LH 
Sbjct: 602  PGSGVPQLFYCLHEIREEAFVSQALNDYHKVVL-RIGNNKEVQVSAFCLKRC---QYLHE 657

Query: 666  YGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNAL 725
               T + +  +  + S+ +H    + PE    L  + + L +   TN  L  L++  + L
Sbjct: 658  VELTVTLNFMNVWKLSSSSHP-GSEAPESNG-LHRWWQDLCSVFATNDKLEVLTMTNSVL 715

Query: 726  GSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFP 785
            G   +K L   LRHP CKLQ L L+R   S+   +DL   L  N++L  +++    V   
Sbjct: 716  GPPFLKALAAALRHPQCKLQKLLLRRVN-STMLNQDLIGVLTGNQHLRYLEIQHVEVESK 774

Query: 786  GMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLR 845
             + LLC  LR P+CRLQ ++L  C        ++ + L  N HL  L L  N+LE+ G  
Sbjct: 775  AVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAY 834

Query: 846  LLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLC 905
             L       V +L  L ++ C LT   C+ LAS L  ++ L  L L+ N L D G   + 
Sbjct: 835  YL------SVAQLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIW 888

Query: 906  EGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGL 965
              L H  C LQ L L  C L    C+ +   L  N  L+ LDLSFN L D G+ LL E L
Sbjct: 889  NALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEAL 948

Query: 966  QHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLS 1023
            ++P C LQ L L++C  T+  C+ +   L  NQ L  L L+ NA+G  G+  LC+  S
Sbjct: 949  KNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFS 1006



 Score =  142 bits (359), Expect = 1e-33
 Identities = 94/275 (34%), Positives = 139/275 (50%), Gaps = 7/275 (2%)

Query: 760  EDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEM 819
            +DL +    N  L  + ++ + +G P +  L   LRHPQC+LQ + LR+    +   Q++
Sbjct: 693  QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVN-STMLNQDL 751

Query: 820  ASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELAST 879
              VL  N HL  L++    +E   ++LLC+ LR P CRL+ L L+ C  T     +L + 
Sbjct: 752  IGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811

Query: 880  LSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQA 939
            L  N  L+ L L  N L + G   L         +L+ L +  C L    CE L+  L+ 
Sbjct: 812  LQGNGHLKTLILRKNSLENCGAYYLS------VAQLERLSIENCNLTQLTCESLASCLRQ 865

Query: 940  NHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQT 999
            +  L  L L+ N L D G   +   L H  C LQ+L L  C LT   C+++   L  N+T
Sbjct: 866  SKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKT 925

Query: 1000 LTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 1034
            L  L L+ N+L D GV LLC+ L +P C L++L L
Sbjct: 926  LKSLDLSFNSLKDDGVILLCEALKNPDCTLQILEL 960



 Score =  110 bits (274), Expect = 9e-24
 Identities = 80/223 (35%), Positives = 110/223 (49%), Gaps = 7/223 (3%)

Query: 817  QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
            Q++ SV  TN  L  L +T + L    L+ L   LRHP C+L+ L L+    T    D L
Sbjct: 693  QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQD-L 751

Query: 877  ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936
               L+ NQ LR L++   E+    V LLC  LR P C+LQ LRL  C         L   
Sbjct: 752  IGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811

Query: 937  LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGI 996
            LQ N +L+ L L  N L + G + L+        +L++L +++C LT   CE+L   L  
Sbjct: 812  LQGNGHLKTLILRKNSLENCGAYYLS------VAQLERLSIENCNLTQLTCESLASCLRQ 865

Query: 997  NQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDL 1039
            ++ LT L L  NAL D G + +   L H  C L+ L L   DL
Sbjct: 866  SKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDL 908



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 38/102 (37%), Positives = 61/102 (59%)

Query: 703  EHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDL 762
            + + +ALC N  L  L L  N+L   GV LLC+ L++P+C LQ L L+ C  +S  C+ +
Sbjct: 914  QDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAM 973

Query: 763  SAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 804
            ++ L  N++L  +DLS N +G  G++ LCE     + R ++I
Sbjct: 974  ASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVI 1015


>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
            3 [Homo sapiens]
          Length = 1037

 Score =  444 bits (1142), Expect = e-124
 Identities = 343/1062 (32%), Positives = 506/1062 (47%), Gaps = 62/1062 (5%)

Query: 13   LSTYLEELEAVELKKFKLYLGT-ATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWR 71
            L T LE+L   ELK FK  L     E    K PW  +E+A   ++A++L+          
Sbjct: 10   LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69

Query: 72   LALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRD 131
              ++  E +N  +L +  + E ++ D   G    + N      E      +   +E +R+
Sbjct: 70   ATVNILEEMNLTELCKMAKAE-MMED---GQVQEIDNPELGDAEEDSELAKPGEKEGWRN 125

Query: 132  YVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQA 191
             + ++  L+       G+  N             H +     Q+ +              
Sbjct: 126  SMEKQ-SLVWKNTFWQGDIDNF------------HDDVTLRNQRFIP------------- 159

Query: 192  SPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYIN 251
                      P   R   P TVV+ G AG+GK+ LA K MLDW D  L      Y FY++
Sbjct: 160  -------FLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLS 211

Query: 252  CREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWC 311
            C+E+++    CS  +LI   WPE    +  ++   +R+LF++DG DELK          C
Sbjct: 212  CKELSRMGP-CSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDIC 270

Query: 312  LCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERK 371
              WE+K+P  +LL SL+++K+LP  +LL+TTRP AL  L  L + P +V + GF E +R+
Sbjct: 271  GDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRR 330

Query: 372  EYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTT 431
             YF ++F + +QA + F  +R N  LF +   P VCW+VCT L+ Q+E G     T  T 
Sbjct: 331  AYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTR 390

Query: 432  TAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDV 491
            T +++ +L S     P   +L+     R L  LAA GLW Q  +F  +DL + G+   D+
Sbjct: 391  TGLFLRFLCSRF---PQGAQLRGA--LRTLSLLAAQGLWAQMSVFHREDLERLGVQESDL 445

Query: 492  SAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYIL--DEGE---GGAGPDQDVTRLLT 546
              FL+ +I ++D   +  YSFIHLSFQ+F  A++Y L  +EGE   G A    DV +LL+
Sbjct: 446  RLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS 505

Query: 547  EYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTL 606
                 +   L     FLFGL NE+    LE +   ++SP IK +LLQ  ++   ++    
Sbjct: 506  GEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQ-CKAHLHANKPLS 564

Query: 607  QQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLY 666
                 E   CLYE QEEE  +  ++ F+ I + ++ +  E M  SF LK C+  Q L L 
Sbjct: 565  VTDLKEVLGCLYESQEEELAKVVVAPFKEISI-HLTNTSEVMHCSFSLKHCQDLQKLSLQ 623

Query: 667  GA--TYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALC----TNPNLIELSL 720
             A   +  +  D            + +P      D  S  L    C    +N NL  L +
Sbjct: 624  VAKGVFLENYMDFELDIEFERCTYLTIP-NWARQDLRSLRLWTDFCSLFSSNSNLKFLEV 682

Query: 721  YRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGN 780
             ++ L    V++LC  +    C LQ + +K      +A  D   A I  K LT + L+G+
Sbjct: 683  KQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFCLAFIGKKTLTHLTLAGH 741

Query: 781  GVGFPGMML-LCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNAL 839
                  MML LC+ LR+ +C LQ ++L           E   VL  N  L  L L+ N L
Sbjct: 742  IEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVL 801

Query: 840  EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL 899
             D G  LL + +  P   L+ L L+ CRLT A+C +LA+ L V++ L  L L+ N +GD 
Sbjct: 802  LDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDT 861

Query: 900  GVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLW 959
            GV  LCEGL +P CKLQTL L  C +    C  LS  LQ   +L  LDLS N +   GLW
Sbjct: 862  GVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLW 920

Query: 960  LLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLC 1019
            +L + L++P C L+ L L SC L    C++L   L  NQ L  L L  N L  +G+  L 
Sbjct: 921  ILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLF 980

Query: 1020 KRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC 1061
              L      L++L L   + N      L  ++   P L I C
Sbjct: 981  GVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTIDC 1022


>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform 1
            [Homo sapiens]
          Length = 1009

 Score =  443 bits (1139), Expect = e-124
 Identities = 340/1058 (32%), Positives = 502/1058 (47%), Gaps = 82/1058 (7%)

Query: 13   LSTYLEELEAVELKKFKLYLGT-ATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWR 71
            L T LE+L   ELK FK  L     E    K PW  +E+A   ++A++L+          
Sbjct: 10   LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69

Query: 72   LALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRD 131
              ++  E +N  +L +  + E ++ D   G    + N      E      +   +E +R+
Sbjct: 70   ATVNILEEMNLTELCKMAKAE-MMED---GQVQEIDNPELGDAEEDSELAKPGEKEGWRN 125

Query: 132  YVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQA 191
             + ++  L+       G+  N             H +     Q+ +              
Sbjct: 126  SMEKQ-SLVWKNTFWQGDIDNF------------HDDVTLRNQRFIP------------- 159

Query: 192  SPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYIN 251
                      P   R   P TVV+ G AG+GK+ LA K MLDW D  L      Y FY++
Sbjct: 160  -------FLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLS 211

Query: 252  CREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWC 311
            C+E+++    CS  +LI   WPE    +  ++   +R+LF++DG DELK          C
Sbjct: 212  CKELSRMGP-CSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDIC 270

Query: 312  LCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERK 371
              WE+K+P  +LL SL+++K+LP  +LL+TTRP AL  L  L + P +V + GF E +R+
Sbjct: 271  GDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRR 330

Query: 372  EYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTT 431
             YF ++F + +QA + F  +R N  LF +   P VCW+VCT L+ Q+E G     T  T 
Sbjct: 331  AYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTR 390

Query: 432  TAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDV 491
            T +++ +L S     P   +L+     R L  LAA GLW Q  +F  +DL + G+   D+
Sbjct: 391  TGLFLRFLCSRF---PQGAQLRGA--LRTLSLLAAQGLWAQMSVFHREDLERLGVQESDL 445

Query: 492  SAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILD--EGE---GGAGPDQDVTRLLT 546
              FL+ +I ++D   +  YSFIHLSFQ+F  A++Y L+  EGE   G A    DV +LL+
Sbjct: 446  RLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS 505

Query: 547  EYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTL 606
                 +   L     FLFGL NE+    LE +   ++SP IK +LLQ  ++   ++    
Sbjct: 506  GEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQ-CKAHLHANKPLS 564

Query: 607  QQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLY 666
                 E   CLYE QEEE  +  ++ F+ I + ++ +  E M  SF LK C+  Q L L 
Sbjct: 565  VTDLKEVLGCLYESQEEELAKVVVAPFKEISI-HLTNTSEVMHCSFSLKHCQDLQKLSLQ 623

Query: 667  GATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAAL--CTNPNLIELSLYRNA 724
             A                         + V L+ Y +         +N NL  L + ++ 
Sbjct: 624  VA-------------------------KGVFLENYMDFELDIEFESSNSNLKFLEVKQSF 658

Query: 725  LGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGF 784
            L    V++LC  +    C LQ + +K      +A  D   A I  K LT + L+G+    
Sbjct: 659  LSDSSVRILCDHVTRSTCHLQKVEIKNVT-PDTAYRDFCLAFIGKKTLTHLTLAGHIEWE 717

Query: 785  PGMML-LCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLG 843
              MML LC+ LR+ +C LQ ++L           E   VL  N  L  L L+ N L D G
Sbjct: 718  RTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEG 777

Query: 844  LRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLL 903
              LL + +  P   L+ L L+ CRLT A+C +LA+ L V++ L  L L+ N +GD GV  
Sbjct: 778  AMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKF 837

Query: 904  LCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAE 963
            LCEGL +P CKLQTL L  C +    C  LS  LQ   +L  LDLS N +   GLW+L +
Sbjct: 838  LCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQ 896

Query: 964  GLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLS 1023
             L++P C L+ L L SC L    C++L   L  NQ L  L L  N L  +G+  L   L 
Sbjct: 897  ALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLR 956

Query: 1024 HPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC 1061
                 L++L L   + N      L  ++   P L I C
Sbjct: 957  QRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTIDC 994


>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
          Length = 892

 Score =  429 bits (1103), Expect = e-120
 Identities = 301/888 (33%), Positives = 456/888 (51%), Gaps = 80/888 (9%)

Query: 17  LEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRLALST 76
           LEEL   +LK+F+  L      G   IPWG +E+A  +++A+ L   +GPE A  +A  T
Sbjct: 26  LEELSQEQLKRFRHKLRDVGPDGRS-IPWGRLERADAVDLAEQLAQFYGPEPALEVARKT 84

Query: 77  FERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRRK 136
            +R + +D+  + Q   L R         LG  S  LL VS      + ++ YR++V + 
Sbjct: 85  LKRADARDVAAQLQERRLQR---------LGLGSGTLLSVS------EYKKKYREHVLQL 129

Query: 137 FRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASPIKI 196
              +++RNAR    V ++ R+T+LL+  E + P +      +   G AR    ++     
Sbjct: 130 HARVKERNAR---SVKITKRFTKLLIAPESAAPEEALGPAEEPEPGRAR----RSDTHTF 182

Query: 197 ETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMN 256
             LF  DEE   P  TVV+QG AGIGK+M A K++ DWA GKL+QG+ D+ F++ C E+ 
Sbjct: 183 NRLFRRDEEGRRP-LTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELL 241

Query: 257 QSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEE 316
           +     S+ DLI    P+  AP+ +++  P+RLLFI+DG DEL P+   P+   C    E
Sbjct: 242 ERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLLFILDGADEL-PALGGPEAAPCTDPFE 300

Query: 317 KRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYK 376
                 +L  L+ K LLP   LL+TTR  A  +L   L  P+  E+ GFS+ ++K+YFYK
Sbjct: 301 AASGARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYK 360

Query: 377 YFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYM 436
           +F +  +A + + +V++NE LF +CFVP VCW+VCT L+QQLE G  L +TS+TTT+VY+
Sbjct: 361 FFRDERRAERAYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYL 420

Query: 437 LYLLSLMQPKPGA--PRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSA- 493
           L++ S++   P A  PRLQ   + R LC LA +G+  ++  F E++L +  L G  V   
Sbjct: 421 LFITSVLSSAPVADGPRLQG--DLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTL 478

Query: 494 FLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQDVTRLLTEYAFSER 553
           FL+       +  E  Y FI  SFQEF AA+ Y+L++G         V  LL   A    
Sbjct: 479 FLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDA-QPH 537

Query: 554 SFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQS------------ 601
           S L LT+RFLFGLL+ E    +E+     VS  +K + L+W+Q + Q             
Sbjct: 538 SHLVLTTRFLFGLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGA 597

Query: 602 -------DGSTLQQGS-----LEFFSCLYEIQEEEFIQQALSHFQVIVVSNIA-SKMEHM 648
                  +    ++G      LE   CLYE QE+ F++QAL  F  + +  +   +M+  
Sbjct: 598 KGLEDTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVA 657

Query: 649 VSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAA 708
           V S+C++ C + Q L L      A  +++ + S G              L A     +++
Sbjct: 658 VLSYCVRCCPAGQALRLISCRLVA-AQEKKKKSLGKR------------LQASLGGGSSS 704

Query: 709 LCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIA 768
             T   L    L+           L Q +  P C L +L L  C++  + C DLS AL A
Sbjct: 705 QGTTKQLPASLLHP----------LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRA 754

Query: 769 NKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH 828
              LT + L  N +   G+ +L EGL  PQCR+Q ++++    + G  Q +  +L  +P 
Sbjct: 755 APALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPDPQRG-LQYLVGMLRQSPA 813

Query: 829 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
           L  LDL+G  L    +  LC  L+H  C L+TL L    L+  +  EL
Sbjct: 814 LTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQEL 861



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 54/156 (34%), Positives = 77/156 (49%), Gaps = 1/156 (0%)

Query: 904  LCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAE 963
            L + +  P C L +L L  C+L  A C  LS  L+A   L EL L  N L + GL +L+E
Sbjct: 719  LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778

Query: 964  GLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLS 1023
            GL  P CR+Q + +       +  + L   L  +  LT L L+   L    V  LC  L 
Sbjct: 779  GLAWPQCRVQTVRVQLPD-PQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837

Query: 1024 HPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059
            H GC L+ L L  ++L++ +   L A++  KP L I
Sbjct: 838  HQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 55/167 (32%), Positives = 83/167 (49%), Gaps = 4/167 (2%)

Query: 844  LRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLL 903
            L  L Q +  P+C L +L L  C+L  A C +L+  L    +L EL L  N L + G+ +
Sbjct: 716  LHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRM 775

Query: 904  LCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAE 963
            L EGL  P C++QT+R+ +        + L  +L+ +  L  LDLS   L    +  L  
Sbjct: 776  LSEGLAWPQCRVQTVRVQLPD-PQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCA 834

Query: 964  GLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNAL 1010
             LQH  C LQ L L S  L+ ++ + L     + +   DL +T+ AL
Sbjct: 835  VLQHQGCGLQTLSLASVELSEQSLQELQ---AVKRAKPDLVITHPAL 878


>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
           2 [Homo sapiens]
          Length = 980

 Score =  420 bits (1080), Expect = e-117
 Identities = 318/978 (32%), Positives = 472/978 (48%), Gaps = 62/978 (6%)

Query: 13  LSTYLEELEAVELKKFKLYLGT-ATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWR 71
           L T LE+L   ELK FK  L     E    K PW  +E+A   ++A++L+          
Sbjct: 10  LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69

Query: 72  LALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRD 131
             ++  E +N  +L +  + E ++ D   G    + N      E      +   +E +R+
Sbjct: 70  ATVNILEEMNLTELCKMAKAE-MMED---GQVQEIDNPELGDAEEDSELAKPGEKEGWRN 125

Query: 132 YVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQA 191
            + ++  L+       G+  N             H +     Q+ +              
Sbjct: 126 SMEKQ-SLVWKNTFWQGDIDNF------------HDDVTLRNQRFIP------------- 159

Query: 192 SPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYIN 251
                     P   R   P TVV+ G AG+GK+ LA K MLDW D  L      Y FY++
Sbjct: 160 -------FLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLS 211

Query: 252 CREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWC 311
           C+E+++    CS  +LI   WPE    +  ++   +R+LF++DG DELK          C
Sbjct: 212 CKELSRMGP-CSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDIC 270

Query: 312 LCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERK 371
             WE+K+P  +LL SL+++K+LP  +LL+TTRP AL  L  L + P +V + GF E +R+
Sbjct: 271 GDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRR 330

Query: 372 EYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTT 431
            YF ++F + +QA + F  +R N  LF +   P VCW+VCT L+ Q+E G     T  T 
Sbjct: 331 AYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTR 390

Query: 432 TAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDV 491
           T +++ +L S     P   +L+     R L  LAA GLW Q  +F  +DL + G+   D+
Sbjct: 391 TGLFLRFLCSRF---PQGAQLRGA--LRTLSLLAAQGLWAQMSVFHREDLERLGVQESDL 445

Query: 492 SAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYIL--DEGE---GGAGPDQDVTRLLT 546
             FL+ +I ++D   +  YSFIHLSFQ+F  A++Y L  +EGE   G A    DV +LL+
Sbjct: 446 RLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS 505

Query: 547 EYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTL 606
                +   L     FLFGL NE+    LE +   ++SP IK +LLQ  ++   ++    
Sbjct: 506 GEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQ-CKAHLHANKPLS 564

Query: 607 QQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLY 666
                E   CLYE QEEE  +  ++ F+ I + ++ +  E M  SF LK C+  Q L L 
Sbjct: 565 VTDLKEVLGCLYESQEEELAKVVVAPFKEISI-HLTNTSEVMHCSFSLKHCQDLQKLSLQ 623

Query: 667 GA--TYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALC----TNPNLIELSL 720
            A   +  +  D            + +P      D  S  L    C    +N NL  L +
Sbjct: 624 VAKGVFLENYMDFELDIEFERCTYLTIP-NWARQDLRSLRLWTDFCSLFSSNSNLKFLEV 682

Query: 721 YRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGN 780
            ++ L    V++LC  +    C LQ + +K      +A  D   A I  K LT + L+G+
Sbjct: 683 KQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFCLAFIGKKTLTHLTLAGH 741

Query: 781 GVGFPGMML-LCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNAL 839
                 MML LC+ LR+ +C LQ ++L           E   VL  N  L  L L+ N L
Sbjct: 742 IEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVL 801

Query: 840 EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL 899
            D G  LL + +  P   L+ L L+ CRLT A+C +LA+ L V++ L  L L+ N +GD 
Sbjct: 802 LDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDT 861

Query: 900 GVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLW 959
           GV  LCEGL +P CKLQTL L  C +    C  LS  LQ   +L  LDLS N +   GLW
Sbjct: 862 GVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLW 920

Query: 960 LLAEGLQHPACRLQKLWL 977
           +L + L++P C L+ L L
Sbjct: 921 ILCQALENPNCNLKHLRL 938



 Score =  107 bits (267), Expect = 6e-23
 Identities = 59/156 (37%), Positives = 89/156 (57%), Gaps = 1/156 (0%)

Query: 709 LCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIA 768
           L  N +L  L L  N L   G  LL + +  P   LQ L L+ CR++ ++C+DL+A L+ 
Sbjct: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844

Query: 769 NKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH 828
           +K LT + L+ N +G  G+  LCEGL +P C+LQ + L++C +    C+ ++  L     
Sbjct: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACS 904

Query: 829 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 864
           L  LDL+ N +   GL +LCQ L +P C L+ L LK
Sbjct: 905 LTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLK 939



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 53/145 (36%), Positives = 79/145 (54%), Gaps = 1/145 (0%)

Query: 685 HTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKL 744
           H L +   E   L +A  + LAA L  +  L  L L +N +G  GVK LC+GL +P+CKL
Sbjct: 818 HFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKL 877

Query: 745 QNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 804
           Q L L++C I+   C  LS AL    +LT +DLS N +   G+ +LC+ L +P C L+ +
Sbjct: 878 QTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHL 936

Query: 805 QLRKCQLESGACQEMASVLGTNPHL 829
           +L+  +      + +  V   NP L
Sbjct: 937 RLKTYETNLEIKKLLEEVKEKNPKL 961


>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
            sapiens]
          Length = 287

 Score =  406 bits (1044), Expect = e-113
 Identities = 223/326 (68%), Positives = 236/326 (72%), Gaps = 59/326 (18%)

Query: 736  GLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 795
            GL  P  + Q L LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR
Sbjct: 21   GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78

Query: 796  HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 855
            HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV
Sbjct: 79   HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138

Query: 856  CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 915
            CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL
Sbjct: 139  CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198

Query: 916  QTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKL 975
            QTLRL  C L + ACE L   L  N  L +L L+ N LGD G+ LL + L HP C+L+ L
Sbjct: 199  QTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 258

Query: 976  WLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 1035
            WL              F + +N                       +++H           
Sbjct: 259  WL--------------FGMDLN-----------------------KMTH----------- 270

Query: 1036 GMDLNKMTHSRLAALRVTKPYLDIGC 1061
                     SRLAALRVTKPYLDIGC
Sbjct: 271  ---------SRLAALRVTKPYLDIGC 287



 Score =  228 bits (580), Expect = 3e-59
 Identities = 111/218 (50%), Positives = 152/218 (69%)

Query: 703 EHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDL 762
           E L+AAL  N NL  + L  N +G  G+ LLC+GLRHP C+LQ ++L++C++ S AC+++
Sbjct: 43  EDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEM 102

Query: 763 SAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASV 822
           ++ L  N +L  +DL+GN +   G+ LLC+GLRHP CRL+ + L+ C+L + AC E+AS 
Sbjct: 103 ASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELAST 162

Query: 823 LGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSV 882
           L  N  L ELDL+ N L DLG+ LLC+GLRHP C+L+TL L  C LTA AC+ L  TL +
Sbjct: 163 LSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGI 222

Query: 883 NQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 920
           NQ+L +L L+ N LGD GV LLC+ L HP CKL+ L L
Sbjct: 223 NQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260



 Score =  106 bits (264), Expect = 1e-22
 Identities = 57/133 (42%), Positives = 79/133 (59%)

Query: 697 LLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISS 756
           L  A  + LA+ L  N +L EL L  N LG  GV LLC+GLRHP CKLQ LRL  C +++
Sbjct: 151 LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTA 210

Query: 757 SACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGAC 816
            ACE+L   L  N+ LT + L+ N +G  G+ LLC+ L HP C+L+++ L    L     
Sbjct: 211 KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTH 270

Query: 817 QEMASVLGTNPHL 829
             +A++  T P+L
Sbjct: 271 SRLAALRVTKPYL 283


>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
          Length = 1033

 Score =  391 bits (1005), Expect = e-108
 Identities = 292/1051 (27%), Positives = 476/1051 (45%), Gaps = 97/1051 (9%)

Query: 16   YLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRLALS 75
            YLE L   E + FK YL  A ++ + K+P   + +    E+A +L   +  +  W +  S
Sbjct: 14   YLENLSDKEFQSFKKYL--ARKILDFKLPQFPLIQMTKEELANVLPISYEGQYIWNMLFS 71

Query: 76   TFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRR 135
             F  + ++DL  +                             ++  R   QE  +  +RR
Sbjct: 72   IFSMMRKEDLCRK-----------------------------IIGRRNRNQEACKAVMRR 102

Query: 136  KFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASPIK 195
            KF L  +           SH +                      G+ H +     +S + 
Sbjct: 103  KFMLQWE-----------SHTF----------------------GKFHYKFFRDVSSDVF 129

Query: 196  --IETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCR 253
              ++  ++           V + G    GK+++ +  +L W  G+++Q    Y+ ++   
Sbjct: 130  YILQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAH 189

Query: 254  EMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLC 313
            E+NQ  T  S+ +LI   WP+  AP+ +++  P++LLFI++  D ++   +  +   C  
Sbjct: 190  EINQM-TNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSN 248

Query: 314  WEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEY 373
              +K P  +LL SL+++K+ P    LI++RPT    +   L+       L  S  +R+ Y
Sbjct: 249  STQKVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIY 308

Query: 374  FYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTA 433
            F  +F + ++A      V ++E L  +C V ++CW+ CT L++Q++ G   +   +T T 
Sbjct: 309  FNSFFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTD 368

Query: 434  VYMLYLLSLMQPKPGAPRLQPPPNQ-RGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVS 492
            ++  +L   +  + G    Q      + LC LAA GL+   + F  +DLR  G    DVS
Sbjct: 369  LHAHFLADALTSEAGLTANQYHLGLLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVS 428

Query: 493  AFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQDVTRLLTEYAFSE 552
                 NI       +  Y FIHL+ QEF  A+ +++      A P+  +     EY    
Sbjct: 429  VLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLM------AVPNYLIPSGSREYKEKR 482

Query: 553  RSFLALTS--RFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQ----SKAQSDGSTL 606
              +        F+FGLLN   R  LE S  +++     +D  +W           D   L
Sbjct: 483  EQYSDFNQVFTFIFGLLNANRRKILETSFGYQLP---MVDSFKWYSVGYMKHLDRDPEKL 539

Query: 607  QQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLY 666
                +  F CLYE +EEEF++  +     + V  + S  + MVS +CL  C   + L L 
Sbjct: 540  TH-HMPLFYCLYENREEEFVKTIVDALMEVTVY-LQSDKDMMVSLYCLDYCCHLRTLKLS 597

Query: 667  GATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALG 726
                  + E   R +A     LV           Y   + +   T  +L EL ++ N L 
Sbjct: 598  VQRIFQNKEPLIRPTASQMKSLV-----------YWREICSLFYTMESLRELHIFDNDLN 646

Query: 727  SRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPG 786
                ++L + L H +CKL+ L+L     ++S  EDL  AL  N++LT + ++   +    
Sbjct: 647  GISERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLKALARNRSLTYLSINCTSISLNM 705

Query: 787  MMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRL 846
              LL + L  P C++  + L KC L +  C+E+AS+L +   L +L L+ N L   G+ +
Sbjct: 706  FSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNI 765

Query: 847  LCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCE 906
            LC  L HP C L +L L  C LT   C  L   L  + +LR+LDL +N L + GVL +  
Sbjct: 766  LCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTF 825

Query: 907  GLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQ 966
             L  PTC+L+ L L  C   S  C+ +++V+  N  LR L++  N + D G+ LL  GL+
Sbjct: 826  PLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLR 885

Query: 967  HPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPG 1026
            HP C L  + L+ C LT+  C +L   L  N+TL  L L  N LG+ GV  L + L  P 
Sbjct: 886  HPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPD 945

Query: 1027 CKLRVLWLFGMDLNKMTHSRLAALRVTKPYL 1057
            C L+V+ L    LN  T   L  ++  KP L
Sbjct: 946  CVLKVVGLPLTGLNTQTQQLLMTVKERKPSL 976



 Score =  138 bits (347), Expect = 3e-32
 Identities = 89/289 (30%), Positives = 140/289 (48%), Gaps = 1/289 (0%)

Query: 770  KNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHL 829
            ++L  + +  N +      +L + L H  C+L+ ++L      SG  +++   L  N  L
Sbjct: 633  ESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGF-EDLLKALARNRSL 691

Query: 830  VELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLREL 889
              L +   ++      LL   L  P C++  L L  C L A+ C+E+AS L    SLR+L
Sbjct: 692  TYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKL 751

Query: 890  DLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLS 949
             LS N L   G+ +LC+ L HP C L +L L  C L    C  L  VL  +  LR+LDL 
Sbjct: 752  TLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLC 811

Query: 950  FNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNA 1009
             N L ++G+  +   L  P C+L++L L  C  ++  C+ +   +  N+ L  L + +N 
Sbjct: 812  VNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNK 871

Query: 1010 LGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLD 1058
            + D G++LLC  L HP C L  + L    L       LA++  T   L+
Sbjct: 872  IEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLE 920



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 57/172 (33%), Positives = 91/172 (52%), Gaps = 3/172 (1%)

Query: 703  EHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDL 762
            +++A  + TN  L  L +  N +   G++LLC GLRHPNC L N+ L+ C ++S+ C  L
Sbjct: 850  QYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSL 909

Query: 763  SAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASV 822
            ++ L  NK L R++L  N +G  G+  L E L  P C L+++ L    L +   Q + +V
Sbjct: 910  ASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTV 969

Query: 823  LGTNPHLVELDLTGNALE--DLGLRLLCQ-GLRHPVCRLRTLWLKICRLTAA 871
                P L+ L  T +  E  ++G+    Q G   P   L  ++ K  R++AA
Sbjct: 970  KERKPSLIFLSETWSLKEGREIGVTPASQPGSIIPNSNLDYMFFKFPRMSAA 1021


>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
          Length = 655

 Score =  346 bits (887), Expect = 8e-95
 Identities = 226/638 (35%), Positives = 348/638 (54%), Gaps = 71/638 (11%)

Query: 17  LEELEAVELKKFKLYLGTATELGEGKIPW--GSMEKAGPLEMAQLLITHFGPEEAWRLAL 74
           L +LE  + KK K YL   T L EG+ P   G +E   P+++A+LLI+ +G +EA ++ L
Sbjct: 17  LSDLEENDFKKLKFYLRDMT-LSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVL 75

Query: 75  STFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVR 134
              + +N  +L ++                       CL          D +E YR++VR
Sbjct: 76  KGLKVMNLLELVDQLSH-------------------ICL---------HDYREVYREHVR 107

Query: 135 RKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQA-SP 193
                 E           ++ RY ++LLV + S+         ++    A     Q    
Sbjct: 108 CLEEWQE---------AGVNGRYNQVLLVAKPSS---------ESPESLACPFPEQELES 149

Query: 194 IKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCR 253
           + +E LF+  E+    P  VV+QG+AG GK+ LA K++LDWA G L+ GRFDY+FY++C+
Sbjct: 150 VTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCK 209

Query: 254 EMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLC 313
           E+     E  ++ L+F C  +  AP+ E++R PERLLFI+DGFDEL+  F +      L 
Sbjct: 210 EV-VLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFEEK-----LK 263

Query: 314 WEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEY 373
                P E LL+ LIR+  LP  SLLITTRP AL  L  LL+  RHV ILGFSE ER  Y
Sbjct: 264 KRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARY 323

Query: 374 FYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTA 433
           F  YF + +QA + F+ V+ N+ L+  C VP +CWVVC+ LQ Q+E G ++ +T R +T 
Sbjct: 324 FSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTD 383

Query: 434 VYMLYLLSLMQPKP--GAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDV 491
           ++M Y+ + + P    G   L      R LCSLAA+G+ +Q+ LFEE +LRKH LDG  +
Sbjct: 384 IFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRL 443

Query: 492 SAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPD--QDVTRLLTEYA 549
           +AFL+ N +Q  +  +++YSF H+SFQ+FF AM Y++ E +   G +  ++V RLL    
Sbjct: 444 AAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESRREVQRLLEVKE 503

Query: 550 FSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQG 609
                 + LT +FL  +  +++ S+LE   C+++SP +  DL  + +       +  +  
Sbjct: 504 QEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHN--RTW 561

Query: 610 SLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEH 647
            LEF   LYE + +  ++        I ++N++ K++H
Sbjct: 562 DLEF--SLYEAKIKNLVKG-------IQMNNVSFKIKH 590


>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  283 bits (724), Expect = 6e-76
 Identities = 150/353 (42%), Positives = 214/353 (60%)

Query: 697  LLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISS 756
            L +A  + +++AL  NP L EL+L  N LG  GV  + QGL+ P+CK+Q L L+ C ++ 
Sbjct: 40   LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 757  SACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGAC 816
            + C  LS+ L     L  + LS N +G  G+ LLCEGL  PQCRL+ +QL  C L + +C
Sbjct: 100  AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 817  QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
            + +ASVL   P   EL ++ N + + G+R+LCQGL+   C+L  L L+ C +T+  C +L
Sbjct: 160  EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 877  ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936
               ++   SLREL L  N+LGD+G+  LC GL HP+ +L+TL +  C + +  C  L  V
Sbjct: 220  CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279

Query: 937  LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGI 996
            L+A  +L+EL L+ N+LGD G  LL E L  P C+L+ LW+ SC  TA  C +    L  
Sbjct: 280  LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQ 339

Query: 997  NQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAA 1049
            N+ L +L ++NN L D GVR LC+ L  PG  LRVLWL   D++  + S LAA
Sbjct: 340  NRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAA 392



 Score =  261 bits (667), Expect = 2e-69
 Identities = 140/355 (39%), Positives = 206/355 (58%)

Query: 705  LAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSA 764
            L++ L T P L EL L  N LG  G++LLC+GL  P C+L+ L+L+ C +S+++CE L++
Sbjct: 105  LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164

Query: 765  ALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLG 824
             L A  +   + +S N +   G+ +LC+GL+   C+L+ ++L  C + S  C+++  ++ 
Sbjct: 165  VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224

Query: 825  TNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQ 884
            +   L EL L  N L D+G+  LC GL HP  RLRTLW+  C +TA  C +L   L   +
Sbjct: 225  SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284

Query: 885  SLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLR 944
            SL+EL L+ NELGD G  LLCE L  P C+L++L +  C   +A C   S VL  N  L 
Sbjct: 285  SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344

Query: 945  ELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLY 1004
            EL +S N L D G+  L +GL  P   L+ LWL  C ++  +C +L  TL  N +L +L 
Sbjct: 345  ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404

Query: 1005 LTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059
            L+NN LGD G+  L + +  PGC L  L L+ +  ++    RL AL   KP L +
Sbjct: 405  LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459



 Score =  237 bits (604), Expect = 5e-62
 Identities = 121/290 (41%), Positives = 176/290 (60%)

Query: 745  QNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 804
            Q +RL  C ++ + C+D+S+AL  N  L  ++L  N +G  G+  + +GL+ P C++Q +
Sbjct: 31   QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90

Query: 805  QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 864
             L+ C L    C  ++S L T P L EL L+ N L D GL+LLC+GL  P CRL  L L+
Sbjct: 91   SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150

Query: 865  ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICR 924
             C L+AA+C+ LAS L      +EL +S N++ + GV +LC+GL+   C+L+ L+L  C 
Sbjct: 151  YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210

Query: 925  LGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTA 984
            + S  C  L  ++ +  +LREL L  N LGD G+  L  GL HP+ RL+ LW+  CG+TA
Sbjct: 211  VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270

Query: 985  KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 1034
            K C +L   L   ++L +L L  N LGD G RLLC+ L  PGC+L  LW+
Sbjct: 271  KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320



 Score =  215 bits (547), Expect = 2e-55
 Identities = 114/278 (41%), Positives = 161/278 (57%)

Query: 700 AYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSAC 759
           A  E LA+ L   P+  EL++  N +   GV++LCQGL+   C+L+ L+L+ C ++S  C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216

Query: 760 EDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEM 819
            DL   + +  +L  + L  N +G  GM  LC GL HP  RL+ + + +C + +  C ++
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDL 276

Query: 820 ASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELAST 879
             VL     L EL L GN L D G RLLC+ L  P C+L +LW+K C  TAA C   +S 
Sbjct: 277 CRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336

Query: 880 LSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQA 939
           L+ N+ L EL +S N L D GV  LC+GL  P   L+ L L  C +  ++C  L+  L A
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396

Query: 940 NHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977
           NH+LRELDLS N LGD G+  L E ++ P C L++L L
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434



 Score =  193 bits (490), Expect = 8e-49
 Identities = 101/238 (42%), Positives = 151/238 (63%), Gaps = 2/238 (0%)

Query: 798  QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 857
            QC  Q+++L  C L    C++++S L  NP L EL+L  N L D+G+  + QGL+ P C+
Sbjct: 29   QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86

Query: 858  LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 917
            ++ L L+ C LT A C  L+STL    +L+EL LS N LGD G+ LLCEGL  P C+L+ 
Sbjct: 87   IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146

Query: 918  LRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977
            L+L  C L +A+CE L+ VL+A  + +EL +S ND+ + G+ +L +GL+   C+L+ L L
Sbjct: 147  LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206

Query: 978  DSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 1035
            +SCG+T+  C +L   +    +L +L L +N LGD G+  LC  L HP  +LR LW++
Sbjct: 207  ESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264



 Score =  105 bits (262), Expect = 2e-22
 Identities = 65/170 (38%), Positives = 95/170 (55%), Gaps = 4/170 (2%)

Query: 886  LRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRE 945
            ++ LD+   EL D     L   L+    + Q +RL  C L  A C+ +S  L+ N  L E
Sbjct: 5    IQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALAE 60

Query: 946  LDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYL 1005
            L+L  N+LGD G+  + +GLQ P+C++QKL L +C LT   C  L  TL    TL +L+L
Sbjct: 61   LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 1006 TNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKP 1055
            ++N LGD G++LLC+ L  P C+L  L L    L+  +   LA++   KP
Sbjct: 121  SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 21/51 (41%), Positives = 27/51 (52%)

Query: 699 DAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRL 749
           D+    LAA L  N +L EL L  N LG  G+  L + +R P C L+ L L
Sbjct: 384 DSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434


>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  283 bits (724), Expect = 6e-76
 Identities = 150/353 (42%), Positives = 214/353 (60%)

Query: 697  LLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISS 756
            L +A  + +++AL  NP L EL+L  N LG  GV  + QGL+ P+CK+Q L L+ C ++ 
Sbjct: 40   LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 757  SACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGAC 816
            + C  LS+ L     L  + LS N +G  G+ LLCEGL  PQCRL+ +QL  C L + +C
Sbjct: 100  AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 817  QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
            + +ASVL   P   EL ++ N + + G+R+LCQGL+   C+L  L L+ C +T+  C +L
Sbjct: 160  EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 877  ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936
               ++   SLREL L  N+LGD+G+  LC GL HP+ +L+TL +  C + +  C  L  V
Sbjct: 220  CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279

Query: 937  LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGI 996
            L+A  +L+EL L+ N+LGD G  LL E L  P C+L+ LW+ SC  TA  C +    L  
Sbjct: 280  LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQ 339

Query: 997  NQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAA 1049
            N+ L +L ++NN L D GVR LC+ L  PG  LRVLWL   D++  + S LAA
Sbjct: 340  NRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAA 392



 Score =  261 bits (667), Expect = 2e-69
 Identities = 140/355 (39%), Positives = 206/355 (58%)

Query: 705  LAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSA 764
            L++ L T P L EL L  N LG  G++LLC+GL  P C+L+ L+L+ C +S+++CE L++
Sbjct: 105  LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164

Query: 765  ALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLG 824
             L A  +   + +S N +   G+ +LC+GL+   C+L+ ++L  C + S  C+++  ++ 
Sbjct: 165  VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224

Query: 825  TNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQ 884
            +   L EL L  N L D+G+  LC GL HP  RLRTLW+  C +TA  C +L   L   +
Sbjct: 225  SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284

Query: 885  SLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLR 944
            SL+EL L+ NELGD G  LLCE L  P C+L++L +  C   +A C   S VL  N  L 
Sbjct: 285  SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344

Query: 945  ELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLY 1004
            EL +S N L D G+  L +GL  P   L+ LWL  C ++  +C +L  TL  N +L +L 
Sbjct: 345  ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404

Query: 1005 LTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059
            L+NN LGD G+  L + +  PGC L  L L+ +  ++    RL AL   KP L +
Sbjct: 405  LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459



 Score =  237 bits (604), Expect = 5e-62
 Identities = 121/290 (41%), Positives = 176/290 (60%)

Query: 745  QNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 804
            Q +RL  C ++ + C+D+S+AL  N  L  ++L  N +G  G+  + +GL+ P C++Q +
Sbjct: 31   QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90

Query: 805  QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 864
             L+ C L    C  ++S L T P L EL L+ N L D GL+LLC+GL  P CRL  L L+
Sbjct: 91   SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150

Query: 865  ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICR 924
             C L+AA+C+ LAS L      +EL +S N++ + GV +LC+GL+   C+L+ L+L  C 
Sbjct: 151  YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210

Query: 925  LGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTA 984
            + S  C  L  ++ +  +LREL L  N LGD G+  L  GL HP+ RL+ LW+  CG+TA
Sbjct: 211  VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270

Query: 985  KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 1034
            K C +L   L   ++L +L L  N LGD G RLLC+ L  PGC+L  LW+
Sbjct: 271  KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320



 Score =  215 bits (547), Expect = 2e-55
 Identities = 114/278 (41%), Positives = 161/278 (57%)

Query: 700 AYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSAC 759
           A  E LA+ L   P+  EL++  N +   GV++LCQGL+   C+L+ L+L+ C ++S  C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216

Query: 760 EDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEM 819
            DL   + +  +L  + L  N +G  GM  LC GL HP  RL+ + + +C + +  C ++
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDL 276

Query: 820 ASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELAST 879
             VL     L EL L GN L D G RLLC+ L  P C+L +LW+K C  TAA C   +S 
Sbjct: 277 CRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336

Query: 880 LSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQA 939
           L+ N+ L EL +S N L D GV  LC+GL  P   L+ L L  C +  ++C  L+  L A
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396

Query: 940 NHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977
           NH+LRELDLS N LGD G+  L E ++ P C L++L L
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434



 Score =  193 bits (490), Expect = 8e-49
 Identities = 101/238 (42%), Positives = 151/238 (63%), Gaps = 2/238 (0%)

Query: 798  QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 857
            QC  Q+++L  C L    C++++S L  NP L EL+L  N L D+G+  + QGL+ P C+
Sbjct: 29   QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86

Query: 858  LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 917
            ++ L L+ C LT A C  L+STL    +L+EL LS N LGD G+ LLCEGL  P C+L+ 
Sbjct: 87   IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146

Query: 918  LRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977
            L+L  C L +A+CE L+ VL+A  + +EL +S ND+ + G+ +L +GL+   C+L+ L L
Sbjct: 147  LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206

Query: 978  DSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 1035
            +SCG+T+  C +L   +    +L +L L +N LGD G+  LC  L HP  +LR LW++
Sbjct: 207  ESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264



 Score =  105 bits (262), Expect = 2e-22
 Identities = 65/170 (38%), Positives = 95/170 (55%), Gaps = 4/170 (2%)

Query: 886  LRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRE 945
            ++ LD+   EL D     L   L+    + Q +RL  C L  A C+ +S  L+ N  L E
Sbjct: 5    IQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALAE 60

Query: 946  LDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYL 1005
            L+L  N+LGD G+  + +GLQ P+C++QKL L +C LT   C  L  TL    TL +L+L
Sbjct: 61   LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 1006 TNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKP 1055
            ++N LGD G++LLC+ L  P C+L  L L    L+  +   LA++   KP
Sbjct: 121  SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 21/51 (41%), Positives = 27/51 (52%)

Query: 699 DAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRL 749
           D+    LAA L  N +L EL L  N LG  G+  L + +R P C L+ L L
Sbjct: 384 DSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434


>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  283 bits (724), Expect = 6e-76
 Identities = 150/353 (42%), Positives = 214/353 (60%)

Query: 697  LLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISS 756
            L +A  + +++AL  NP L EL+L  N LG  GV  + QGL+ P+CK+Q L L+ C ++ 
Sbjct: 40   LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 757  SACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGAC 816
            + C  LS+ L     L  + LS N +G  G+ LLCEGL  PQCRL+ +QL  C L + +C
Sbjct: 100  AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 817  QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
            + +ASVL   P   EL ++ N + + G+R+LCQGL+   C+L  L L+ C +T+  C +L
Sbjct: 160  EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 877  ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936
               ++   SLREL L  N+LGD+G+  LC GL HP+ +L+TL +  C + +  C  L  V
Sbjct: 220  CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279

Query: 937  LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGI 996
            L+A  +L+EL L+ N+LGD G  LL E L  P C+L+ LW+ SC  TA  C +    L  
Sbjct: 280  LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQ 339

Query: 997  NQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAA 1049
            N+ L +L ++NN L D GVR LC+ L  PG  LRVLWL   D++  + S LAA
Sbjct: 340  NRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAA 392



 Score =  261 bits (667), Expect = 2e-69
 Identities = 140/355 (39%), Positives = 206/355 (58%)

Query: 705  LAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSA 764
            L++ L T P L EL L  N LG  G++LLC+GL  P C+L+ L+L+ C +S+++CE L++
Sbjct: 105  LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164

Query: 765  ALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLG 824
             L A  +   + +S N +   G+ +LC+GL+   C+L+ ++L  C + S  C+++  ++ 
Sbjct: 165  VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224

Query: 825  TNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQ 884
            +   L EL L  N L D+G+  LC GL HP  RLRTLW+  C +TA  C +L   L   +
Sbjct: 225  SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284

Query: 885  SLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLR 944
            SL+EL L+ NELGD G  LLCE L  P C+L++L +  C   +A C   S VL  N  L 
Sbjct: 285  SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344

Query: 945  ELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLY 1004
            EL +S N L D G+  L +GL  P   L+ LWL  C ++  +C +L  TL  N +L +L 
Sbjct: 345  ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404

Query: 1005 LTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059
            L+NN LGD G+  L + +  PGC L  L L+ +  ++    RL AL   KP L +
Sbjct: 405  LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459



 Score =  237 bits (604), Expect = 5e-62
 Identities = 121/290 (41%), Positives = 176/290 (60%)

Query: 745  QNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 804
            Q +RL  C ++ + C+D+S+AL  N  L  ++L  N +G  G+  + +GL+ P C++Q +
Sbjct: 31   QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90

Query: 805  QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 864
             L+ C L    C  ++S L T P L EL L+ N L D GL+LLC+GL  P CRL  L L+
Sbjct: 91   SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150

Query: 865  ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICR 924
             C L+AA+C+ LAS L      +EL +S N++ + GV +LC+GL+   C+L+ L+L  C 
Sbjct: 151  YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210

Query: 925  LGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTA 984
            + S  C  L  ++ +  +LREL L  N LGD G+  L  GL HP+ RL+ LW+  CG+TA
Sbjct: 211  VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270

Query: 985  KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 1034
            K C +L   L   ++L +L L  N LGD G RLLC+ L  PGC+L  LW+
Sbjct: 271  KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320



 Score =  215 bits (547), Expect = 2e-55
 Identities = 114/278 (41%), Positives = 161/278 (57%)

Query: 700 AYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSAC 759
           A  E LA+ L   P+  EL++  N +   GV++LCQGL+   C+L+ L+L+ C ++S  C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216

Query: 760 EDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEM 819
            DL   + +  +L  + L  N +G  GM  LC GL HP  RL+ + + +C + +  C ++
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDL 276

Query: 820 ASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELAST 879
             VL     L EL L GN L D G RLLC+ L  P C+L +LW+K C  TAA C   +S 
Sbjct: 277 CRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336

Query: 880 LSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQA 939
           L+ N+ L EL +S N L D GV  LC+GL  P   L+ L L  C +  ++C  L+  L A
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396

Query: 940 NHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977
           NH+LRELDLS N LGD G+  L E ++ P C L++L L
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434



 Score =  193 bits (490), Expect = 8e-49
 Identities = 101/238 (42%), Positives = 151/238 (63%), Gaps = 2/238 (0%)

Query: 798  QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 857
            QC  Q+++L  C L    C++++S L  NP L EL+L  N L D+G+  + QGL+ P C+
Sbjct: 29   QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86

Query: 858  LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 917
            ++ L L+ C LT A C  L+STL    +L+EL LS N LGD G+ LLCEGL  P C+L+ 
Sbjct: 87   IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146

Query: 918  LRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977
            L+L  C L +A+CE L+ VL+A  + +EL +S ND+ + G+ +L +GL+   C+L+ L L
Sbjct: 147  LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206

Query: 978  DSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 1035
            +SCG+T+  C +L   +    +L +L L +N LGD G+  LC  L HP  +LR LW++
Sbjct: 207  ESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264



 Score =  105 bits (262), Expect = 2e-22
 Identities = 65/170 (38%), Positives = 95/170 (55%), Gaps = 4/170 (2%)

Query: 886  LRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRE 945
            ++ LD+   EL D     L   L+    + Q +RL  C L  A C+ +S  L+ N  L E
Sbjct: 5    IQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALAE 60

Query: 946  LDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYL 1005
            L+L  N+LGD G+  + +GLQ P+C++QKL L +C LT   C  L  TL    TL +L+L
Sbjct: 61   LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 1006 TNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKP 1055
            ++N LGD G++LLC+ L  P C+L  L L    L+  +   LA++   KP
Sbjct: 121  SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 21/51 (41%), Positives = 27/51 (52%)

Query: 699 DAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRL 749
           D+    LAA L  N +L EL L  N LG  G+  L + +R P C L+ L L
Sbjct: 384 DSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434


>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  283 bits (724), Expect = 6e-76
 Identities = 150/353 (42%), Positives = 214/353 (60%)

Query: 697  LLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISS 756
            L +A  + +++AL  NP L EL+L  N LG  GV  + QGL+ P+CK+Q L L+ C ++ 
Sbjct: 40   LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 757  SACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGAC 816
            + C  LS+ L     L  + LS N +G  G+ LLCEGL  PQCRL+ +QL  C L + +C
Sbjct: 100  AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 817  QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
            + +ASVL   P   EL ++ N + + G+R+LCQGL+   C+L  L L+ C +T+  C +L
Sbjct: 160  EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 877  ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936
               ++   SLREL L  N+LGD+G+  LC GL HP+ +L+TL +  C + +  C  L  V
Sbjct: 220  CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279

Query: 937  LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGI 996
            L+A  +L+EL L+ N+LGD G  LL E L  P C+L+ LW+ SC  TA  C +    L  
Sbjct: 280  LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQ 339

Query: 997  NQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAA 1049
            N+ L +L ++NN L D GVR LC+ L  PG  LRVLWL   D++  + S LAA
Sbjct: 340  NRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAA 392



 Score =  261 bits (667), Expect = 2e-69
 Identities = 140/355 (39%), Positives = 206/355 (58%)

Query: 705  LAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSA 764
            L++ L T P L EL L  N LG  G++LLC+GL  P C+L+ L+L+ C +S+++CE L++
Sbjct: 105  LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164

Query: 765  ALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLG 824
             L A  +   + +S N +   G+ +LC+GL+   C+L+ ++L  C + S  C+++  ++ 
Sbjct: 165  VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224

Query: 825  TNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQ 884
            +   L EL L  N L D+G+  LC GL HP  RLRTLW+  C +TA  C +L   L   +
Sbjct: 225  SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284

Query: 885  SLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLR 944
            SL+EL L+ NELGD G  LLCE L  P C+L++L +  C   +A C   S VL  N  L 
Sbjct: 285  SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344

Query: 945  ELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLY 1004
            EL +S N L D G+  L +GL  P   L+ LWL  C ++  +C +L  TL  N +L +L 
Sbjct: 345  ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404

Query: 1005 LTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059
            L+NN LGD G+  L + +  PGC L  L L+ +  ++    RL AL   KP L +
Sbjct: 405  LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459



 Score =  237 bits (604), Expect = 5e-62
 Identities = 121/290 (41%), Positives = 176/290 (60%)

Query: 745  QNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 804
            Q +RL  C ++ + C+D+S+AL  N  L  ++L  N +G  G+  + +GL+ P C++Q +
Sbjct: 31   QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90

Query: 805  QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 864
             L+ C L    C  ++S L T P L EL L+ N L D GL+LLC+GL  P CRL  L L+
Sbjct: 91   SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150

Query: 865  ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICR 924
             C L+AA+C+ LAS L      +EL +S N++ + GV +LC+GL+   C+L+ L+L  C 
Sbjct: 151  YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210

Query: 925  LGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTA 984
            + S  C  L  ++ +  +LREL L  N LGD G+  L  GL HP+ RL+ LW+  CG+TA
Sbjct: 211  VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270

Query: 985  KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 1034
            K C +L   L   ++L +L L  N LGD G RLLC+ L  PGC+L  LW+
Sbjct: 271  KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320



 Score =  215 bits (547), Expect = 2e-55
 Identities = 114/278 (41%), Positives = 161/278 (57%)

Query: 700 AYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSAC 759
           A  E LA+ L   P+  EL++  N +   GV++LCQGL+   C+L+ L+L+ C ++S  C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216

Query: 760 EDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEM 819
            DL   + +  +L  + L  N +G  GM  LC GL HP  RL+ + + +C + +  C ++
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDL 276

Query: 820 ASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELAST 879
             VL     L EL L GN L D G RLLC+ L  P C+L +LW+K C  TAA C   +S 
Sbjct: 277 CRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336

Query: 880 LSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQA 939
           L+ N+ L EL +S N L D GV  LC+GL  P   L+ L L  C +  ++C  L+  L A
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396

Query: 940 NHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977
           NH+LRELDLS N LGD G+  L E ++ P C L++L L
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434



 Score =  193 bits (490), Expect = 8e-49
 Identities = 101/238 (42%), Positives = 151/238 (63%), Gaps = 2/238 (0%)

Query: 798  QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 857
            QC  Q+++L  C L    C++++S L  NP L EL+L  N L D+G+  + QGL+ P C+
Sbjct: 29   QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86

Query: 858  LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 917
            ++ L L+ C LT A C  L+STL    +L+EL LS N LGD G+ LLCEGL  P C+L+ 
Sbjct: 87   IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146

Query: 918  LRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977
            L+L  C L +A+CE L+ VL+A  + +EL +S ND+ + G+ +L +GL+   C+L+ L L
Sbjct: 147  LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206

Query: 978  DSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 1035
            +SCG+T+  C +L   +    +L +L L +N LGD G+  LC  L HP  +LR LW++
Sbjct: 207  ESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264



 Score =  105 bits (262), Expect = 2e-22
 Identities = 65/170 (38%), Positives = 95/170 (55%), Gaps = 4/170 (2%)

Query: 886  LRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRE 945
            ++ LD+   EL D     L   L+    + Q +RL  C L  A C+ +S  L+ N  L E
Sbjct: 5    IQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALAE 60

Query: 946  LDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYL 1005
            L+L  N+LGD G+  + +GLQ P+C++QKL L +C LT   C  L  TL    TL +L+L
Sbjct: 61   LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 1006 TNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKP 1055
            ++N LGD G++LLC+ L  P C+L  L L    L+  +   LA++   KP
Sbjct: 121  SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 21/51 (41%), Positives = 27/51 (52%)

Query: 699 DAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRL 749
           D+    LAA L  N +L EL L  N LG  G+  L + +R P C L+ L L
Sbjct: 384 DSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434


>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  283 bits (724), Expect = 6e-76
 Identities = 150/353 (42%), Positives = 214/353 (60%)

Query: 697  LLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISS 756
            L +A  + +++AL  NP L EL+L  N LG  GV  + QGL+ P+CK+Q L L+ C ++ 
Sbjct: 40   LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 757  SACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGAC 816
            + C  LS+ L     L  + LS N +G  G+ LLCEGL  PQCRL+ +QL  C L + +C
Sbjct: 100  AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 817  QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
            + +ASVL   P   EL ++ N + + G+R+LCQGL+   C+L  L L+ C +T+  C +L
Sbjct: 160  EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 877  ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936
               ++   SLREL L  N+LGD+G+  LC GL HP+ +L+TL +  C + +  C  L  V
Sbjct: 220  CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279

Query: 937  LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGI 996
            L+A  +L+EL L+ N+LGD G  LL E L  P C+L+ LW+ SC  TA  C +    L  
Sbjct: 280  LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQ 339

Query: 997  NQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAA 1049
            N+ L +L ++NN L D GVR LC+ L  PG  LRVLWL   D++  + S LAA
Sbjct: 340  NRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAA 392



 Score =  261 bits (667), Expect = 2e-69
 Identities = 140/355 (39%), Positives = 206/355 (58%)

Query: 705  LAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSA 764
            L++ L T P L EL L  N LG  G++LLC+GL  P C+L+ L+L+ C +S+++CE L++
Sbjct: 105  LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164

Query: 765  ALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLG 824
             L A  +   + +S N +   G+ +LC+GL+   C+L+ ++L  C + S  C+++  ++ 
Sbjct: 165  VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224

Query: 825  TNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQ 884
            +   L EL L  N L D+G+  LC GL HP  RLRTLW+  C +TA  C +L   L   +
Sbjct: 225  SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284

Query: 885  SLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLR 944
            SL+EL L+ NELGD G  LLCE L  P C+L++L +  C   +A C   S VL  N  L 
Sbjct: 285  SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344

Query: 945  ELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLY 1004
            EL +S N L D G+  L +GL  P   L+ LWL  C ++  +C +L  TL  N +L +L 
Sbjct: 345  ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404

Query: 1005 LTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059
            L+NN LGD G+  L + +  PGC L  L L+ +  ++    RL AL   KP L +
Sbjct: 405  LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459



 Score =  237 bits (604), Expect = 5e-62
 Identities = 121/290 (41%), Positives = 176/290 (60%)

Query: 745  QNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 804
            Q +RL  C ++ + C+D+S+AL  N  L  ++L  N +G  G+  + +GL+ P C++Q +
Sbjct: 31   QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90

Query: 805  QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 864
             L+ C L    C  ++S L T P L EL L+ N L D GL+LLC+GL  P CRL  L L+
Sbjct: 91   SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150

Query: 865  ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICR 924
             C L+AA+C+ LAS L      +EL +S N++ + GV +LC+GL+   C+L+ L+L  C 
Sbjct: 151  YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210

Query: 925  LGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTA 984
            + S  C  L  ++ +  +LREL L  N LGD G+  L  GL HP+ RL+ LW+  CG+TA
Sbjct: 211  VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270

Query: 985  KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 1034
            K C +L   L   ++L +L L  N LGD G RLLC+ L  PGC+L  LW+
Sbjct: 271  KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320



 Score =  215 bits (547), Expect = 2e-55
 Identities = 114/278 (41%), Positives = 161/278 (57%)

Query: 700 AYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSAC 759
           A  E LA+ L   P+  EL++  N +   GV++LCQGL+   C+L+ L+L+ C ++S  C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216

Query: 760 EDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEM 819
            DL   + +  +L  + L  N +G  GM  LC GL HP  RL+ + + +C + +  C ++
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDL 276

Query: 820 ASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELAST 879
             VL     L EL L GN L D G RLLC+ L  P C+L +LW+K C  TAA C   +S 
Sbjct: 277 CRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336

Query: 880 LSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQA 939
           L+ N+ L EL +S N L D GV  LC+GL  P   L+ L L  C +  ++C  L+  L A
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396

Query: 940 NHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977
           NH+LRELDLS N LGD G+  L E ++ P C L++L L
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434



 Score =  193 bits (490), Expect = 8e-49
 Identities = 101/238 (42%), Positives = 151/238 (63%), Gaps = 2/238 (0%)

Query: 798  QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 857
            QC  Q+++L  C L    C++++S L  NP L EL+L  N L D+G+  + QGL+ P C+
Sbjct: 29   QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86

Query: 858  LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 917
            ++ L L+ C LT A C  L+STL    +L+EL LS N LGD G+ LLCEGL  P C+L+ 
Sbjct: 87   IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146

Query: 918  LRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977
            L+L  C L +A+CE L+ VL+A  + +EL +S ND+ + G+ +L +GL+   C+L+ L L
Sbjct: 147  LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206

Query: 978  DSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 1035
            +SCG+T+  C +L   +    +L +L L +N LGD G+  LC  L HP  +LR LW++
Sbjct: 207  ESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264



 Score =  105 bits (262), Expect = 2e-22
 Identities = 65/170 (38%), Positives = 95/170 (55%), Gaps = 4/170 (2%)

Query: 886  LRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRE 945
            ++ LD+   EL D     L   L+    + Q +RL  C L  A C+ +S  L+ N  L E
Sbjct: 5    IQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALAE 60

Query: 946  LDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYL 1005
            L+L  N+LGD G+  + +GLQ P+C++QKL L +C LT   C  L  TL    TL +L+L
Sbjct: 61   LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 1006 TNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKP 1055
            ++N LGD G++LLC+ L  P C+L  L L    L+  +   LA++   KP
Sbjct: 121  SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 21/51 (41%), Positives = 27/51 (52%)

Query: 699 DAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRL 749
           D+    LAA L  N +L EL L  N LG  G+  L + +R P C L+ L L
Sbjct: 384 DSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.138    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,242,010
Number of Sequences: 37866
Number of extensions: 2025650
Number of successful extensions: 5914
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 4943
Number of HSP's gapped (non-prelim): 413
length of query: 1061
length of database: 18,247,518
effective HSP length: 113
effective length of query: 948
effective length of database: 13,968,660
effective search space: 13242289680
effective search space used: 13242289680
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.