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Search of human proteins with 219283190
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|219283190 MAX dimerization protein 3 isoform b [Homo
sapiens]
(193 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|219283190 MAX dimerization protein 3 isoform b [Homo sapiens] 385 e-108
gi|13775222 MAX dimerization protein 3 isoform a [Homo sapiens] 330 5e-91
gi|57242782 MAX interactor 1 isoform a [Homo sapiens] 148 2e-36
gi|4505069 MAX dimerization protein 1 [Homo sapiens] 145 3e-35
gi|5453734 MAD4 [Homo sapiens] 139 1e-33
gi|47717116 MAX interactor 1 isoform b [Homo sapiens] 136 1e-32
gi|57242784 MAX interactor 1 isoform c [Homo sapiens] 100 8e-22
gi|9945318 MAX binding protein [Homo sapiens] 60 9e-10
gi|74315997 l-myc-1 proto-oncogene isoform 1 [Homo sapiens] 52 2e-07
gi|74315995 l-myc-1 proto-oncogene isoform 1 [Homo sapiens] 52 2e-07
gi|71774083 myc proto-oncogene protein [Homo sapiens] 52 2e-07
gi|19923312 v-myc myelocytomatosis viral related oncogene, neuro... 46 2e-05
gi|8659574 transcription factor E3 [Homo sapiens] 43 1e-04
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 42 2e-04
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 42 2e-04
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 42 2e-04
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 42 2e-04
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 41 7e-04
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 41 7e-04
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 41 7e-04
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 41 7e-04
gi|38156705 microphthalmia-associated transcription factor isofo... 40 0.001
gi|38156703 microphthalmia-associated transcription factor isofo... 40 0.001
gi|38156701 microphthalmia-associated transcription factor isofo... 40 0.001
gi|38156699 microphthalmia-associated transcription factor isofo... 40 0.001
gi|38156697 microphthalmia-associated transcription factor isofo... 40 0.001
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo... 40 0.001
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor... 40 0.001
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 40 0.001
gi|46877105 upstream stimulatory factor 2 isoform 2 [Homo sapiens] 39 0.002
>gi|219283190 MAX dimerization protein 3 isoform b [Homo sapiens]
Length = 193
Score = 385 bits (990), Expect = e-108
Identities = 193/193 (100%), Positives = 193/193 (100%)
Query: 1 MEPLASNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRS 60
MEPLASNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRS
Sbjct: 1 MEPLASNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRS 60
Query: 61 VHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLK 120
VHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLK
Sbjct: 61 VHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLK 120
Query: 121 ERLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQVLPNENGGTPNH 180
ERLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQVLPNENGGTPNH
Sbjct: 121 ERLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQVLPNENGGTPNH 180
Query: 181 RPTGRGNNISSHH 193
RPTGRGNNISSHH
Sbjct: 181 RPTGRGNNISSHH 193
>gi|13775222 MAX dimerization protein 3 isoform a [Homo sapiens]
Length = 206
Score = 330 bits (846), Expect = 5e-91
Identities = 168/168 (100%), Positives = 168/168 (100%)
Query: 1 MEPLASNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRS 60
MEPLASNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRS
Sbjct: 1 MEPLASNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRS 60
Query: 61 VHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLK 120
VHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLK
Sbjct: 61 VHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLK 120
Query: 121 ERLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQ 168
ERLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQ
Sbjct: 121 ERLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQ 168
>gi|57242782 MAX interactor 1 isoform a [Homo sapiens]
Length = 228
Score = 148 bits (374), Expect = 2e-36
Identities = 83/171 (48%), Positives = 113/171 (66%), Gaps = 13/171 (7%)
Query: 7 NIQVLLQAAEFLERREREAEHGYASLCPH---------RSPGPIHRRKKRPPQAPGAQDS 57
N+Q LL+AAEFLERRERE EHGYAS P + P + R +K + +
Sbjct: 8 NVQRLLEAAEFLERRERECEHGYASSFPSMPSPRLQHSKPPRRLSRAQKHSSGSSNTSTA 67
Query: 58 GRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRAR 117
RS HNELEK RRA L+ CLERLK +PLG DC R+TTL LL +A+ HI+KLE+ E++++
Sbjct: 68 NRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQ 127
Query: 118 QLKERLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQ 168
E L +Q+ L+ +LEQL+ G E ER+R DS+ S+ +SS+RSDS++
Sbjct: 128 HQLENLEREQRFLKWRLEQLQ---GPQEMERIRMDSIGST-ISSDRSDSER 174
>gi|4505069 MAX dimerization protein 1 [Homo sapiens]
Length = 221
Score = 145 bits (365), Expect = 3e-35
Identities = 82/162 (50%), Positives = 118/162 (72%), Gaps = 10/162 (6%)
Query: 7 NIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELE 66
NIQ+LL+AA++LERREREAEHGYAS+ P+ + KR ++ S RS HNE+E
Sbjct: 8 NIQMLLEAADYLERREREAEHGYASMLPYNNKD--RDALKRRNKSKKNNSSSRSTHNEME 65
Query: 67 KRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERLRSK 126
K RRA L+ CLE+LK +PLG + +R+TTLSLL +A++HI+KLED +++A ++L+ +
Sbjct: 66 KNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQRE 125
Query: 127 QQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQ 168
Q+ L+RQLE+L G+ ER+R DS+ S+ +SSERSDSD+
Sbjct: 126 QRHLKRQLEKL-GI------ERIRMDSIGST-VSSERSDSDR 159
>gi|5453734 MAD4 [Homo sapiens]
Length = 209
Score = 139 bits (350), Expect = 1e-33
Identities = 80/188 (42%), Positives = 119/188 (63%), Gaps = 7/188 (3%)
Query: 6 SNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNEL 65
+++ +LL+AAE+LERR+REAEHGYAS+ P G R K + + RS HNEL
Sbjct: 4 NSLLILLEAAEYLERRDREAEHGYASVLPF--DGDFAREKTKAAGLVRKAPNNRSSHNEL 61
Query: 66 EKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERLRS 125
EK RRA+L+ LE+LKQ +PLG D R+TTLSLL+RA++HI+KLE+Q++RA +KE+L+
Sbjct: 62 EKHRRAKLRLYLEQLKQLVPLGPDSTRHTTLSLLKRAKVHIKKLEEQDRRALSIKEQLQQ 121
Query: 126 KQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQVLPNENGGTPNHRPTGR 185
+ + L+R+LEQL ER+R DS S +S++ S+ + + G G
Sbjct: 122 EHRFLKRRLEQL----SVQSVERVRTDS-TGSAVSTDDSEQEVDIEGMEFGPGELDSVGS 176
Query: 186 GNNISSHH 193
++ H+
Sbjct: 177 SSDADDHY 184
>gi|47717116 MAX interactor 1 isoform b [Homo sapiens]
Length = 295
Score = 136 bits (343), Expect = 1e-32
Identities = 78/174 (44%), Positives = 112/174 (64%), Gaps = 16/174 (9%)
Query: 7 NIQVLLQAAEFLERRERE---AEHGYASLCPH---------RSPGPIHRRKKRPPQAPGA 54
N+Q+LL+AA +LE+ E+E EHGYAS P + P + R +K +
Sbjct: 72 NVQILLEAASYLEQIEKENKKCEHGYASSFPSMPSPRLQHSKPPRRLSRAQKHSSGSSNT 131
Query: 55 QDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQ 114
+ RS HNELEK RRA L+ CLERLK +PLG DC R+TTL LL +A+ HI+KLE+ E+
Sbjct: 132 STANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAER 191
Query: 115 RARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQ 168
+++ E L +Q+ L+ +LEQL+ G E ER+R DS+ S+ +SS+RSDS++
Sbjct: 192 KSQHQLENLEREQRFLKWRLEQLQ---GPQEMERIRMDSIGST-ISSDRSDSER 241
>gi|57242784 MAX interactor 1 isoform c [Homo sapiens]
Length = 182
Score = 100 bits (249), Expect = 8e-22
Identities = 57/131 (43%), Positives = 82/131 (62%), Gaps = 4/131 (3%)
Query: 38 PGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLS 97
P P + K P + AQ N RRA L+ CLERLK +PLG DC R+TTL
Sbjct: 2 PSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRRAHLRLCLERLKVLIPLGPDCTRHTTLG 61
Query: 98 LLRRARMHIQKLEDQEQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSS 157
LL +A+ HI+KLE+ E++++ E L +Q+ L+ +LEQL+ G E ER+R DS+ S+
Sbjct: 62 LLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWRLEQLQ---GPQEMERIRMDSIGST 118
Query: 158 GLSSERSDSDQ 168
+SS+RSDS++
Sbjct: 119 -ISSDRSDSER 128
>gi|9945318 MAX binding protein [Homo sapiens]
Length = 582
Score = 60.5 bits (145), Expect = 9e-10
Identities = 33/80 (41%), Positives = 50/80 (62%), Gaps = 1/80 (1%)
Query: 59 RSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQ 118
R VHN+LEK RRA LK C E LK+ +P D + + LS+LR A +IQ L+ +E+
Sbjct: 222 REVHNKLEKNRRAHLKECFETLKRNIP-NVDDKKTSNLSVLRTALRYIQSLKRKEKEYEH 280
Query: 119 LKERLRSKQQSLQRQLEQLR 138
ERL ++ + Q++L +L+
Sbjct: 281 EMERLAREKIATQQRLAELK 300
Score = 27.7 bits (60), Expect = 6.3
Identities = 16/37 (43%), Positives = 24/37 (64%), Gaps = 1/37 (2%)
Query: 97 SLLRRARMHIQKLEDQEQRARQLKERLRSKQQSLQRQ 133
+LL AR ++ Q+QRAR+ +ERLR +Q+ Q Q
Sbjct: 5 TLLEAARF-LEWQAQQQQRAREEQERLRLEQEREQEQ 40
>gi|74315997 l-myc-1 proto-oncogene isoform 1 [Homo sapiens]
Length = 364
Score = 52.4 bits (124), Expect = 2e-07
Identities = 28/81 (34%), Positives = 46/81 (56%)
Query: 59 RSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQ 118
R HN LE++RR L+ L+ Q+P A C++ + +L +A ++Q L E+R
Sbjct: 283 RKNHNFLERKRRNDLRSRFLALRDQVPTLASCSKAPKVVILSKALEYLQALVGAEKRMAT 342
Query: 119 LKERLRSKQQSLQRQLEQLRG 139
K +LR +QQ LQ+++ L G
Sbjct: 343 EKRQLRCRQQQLQKRIAYLTG 363
>gi|74315995 l-myc-1 proto-oncogene isoform 1 [Homo sapiens]
Length = 364
Score = 52.4 bits (124), Expect = 2e-07
Identities = 28/81 (34%), Positives = 46/81 (56%)
Query: 59 RSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQ 118
R HN LE++RR L+ L+ Q+P A C++ + +L +A ++Q L E+R
Sbjct: 283 RKNHNFLERKRRNDLRSRFLALRDQVPTLASCSKAPKVVILSKALEYLQALVGAEKRMAT 342
Query: 119 LKERLRSKQQSLQRQLEQLRG 139
K +LR +QQ LQ+++ L G
Sbjct: 343 EKRQLRCRQQQLQKRIAYLTG 363
>gi|71774083 myc proto-oncogene protein [Homo sapiens]
Length = 454
Score = 52.4 bits (124), Expect = 2e-07
Identities = 28/97 (28%), Positives = 56/97 (57%)
Query: 42 HRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRR 101
+R+ P + ++ R HN LE++RR +LKR L+ Q+P + + + +L++
Sbjct: 354 NRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKK 413
Query: 102 ARMHIQKLEDQEQRARQLKERLRSKQQSLQRQLEQLR 138
A +I ++ +EQ+ ++ LR +++ L+ +LEQLR
Sbjct: 414 ATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLR 450
>gi|19923312 v-myc myelocytomatosis viral related oncogene,
neuroblastoma derived [Homo sapiens]
Length = 464
Score = 45.8 bits (107), Expect = 2e-05
Identities = 28/109 (25%), Positives = 53/109 (48%)
Query: 30 ASLCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGAD 89
AS P +S P + P + R HN LE++RR L+ L+ +P
Sbjct: 354 ASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVK 413
Query: 90 CARYTTLSLLRRARMHIQKLEDQEQRARQLKERLRSKQQSLQRQLEQLR 138
+ + +L++A ++ L+ +E + KE+L+++QQ L +++E R
Sbjct: 414 NEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHAR 462
>gi|8659574 transcription factor E3 [Homo sapiens]
Length = 575
Score = 43.1 bits (100), Expect = 1e-04
Identities = 29/109 (26%), Positives = 58/109 (53%), Gaps = 4/109 (3%)
Query: 33 CPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCA- 91
CP P + +A + + HN +E+RRR + ++ L +P +D
Sbjct: 322 CPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEM 381
Query: 92 RYTTLSLLRRARMHIQKLEDQEQRARQLKERLRSKQQ---SLQRQLEQL 137
R+ ++L+ + +I+KL+ ++QR++ L+ R RS +Q SLQ ++++L
Sbjct: 382 RWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQEL 430
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 42.4 bits (98), Expect = 2e-04
Identities = 42/183 (22%), Positives = 81/183 (44%), Gaps = 34/183 (18%)
Query: 6 SNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNEL 65
SN + L Q + ++++R+ E L +H+R++R + +
Sbjct: 364 SNSEALKQQQQLQQQQQRDPEAHIKHL--------LHQRQRR-------------IEEQK 402
Query: 66 EKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERLRS 125
E+RRR + ++ ER ++++ R + LRR Q +QE + +QL+E+ +S
Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQS 462
Query: 126 KQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQVLPNENGGTPNHRPTGR 185
++ LQRQL+Q E L++ ++ Q+LP + ++ GR
Sbjct: 463 ER--LQRQLQQ--------EHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY---GR 509
Query: 186 GNN 188
G N
Sbjct: 510 GMN 512
Score = 29.3 bits (64), Expect = 2.2
Identities = 21/88 (23%), Positives = 41/88 (46%), Gaps = 7/88 (7%)
Query: 68 RRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERLRS-- 125
R + + K E LKQQ L R + +++E+Q++ R+++E+ R
Sbjct: 357 RLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRRER 416
Query: 126 -----KQQSLQRQLEQLRGLAGAAERER 148
+++ QR+LE ++ L ER +
Sbjct: 417 EQRKLQEKEQQRRLEDMQALRREEERRQ 444
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 42.4 bits (98), Expect = 2e-04
Identities = 42/183 (22%), Positives = 81/183 (44%), Gaps = 34/183 (18%)
Query: 6 SNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNEL 65
SN + L Q + ++++R+ E L +H+R++R + +
Sbjct: 364 SNSEALKQQQQLQQQQQRDPEAHIKHL--------LHQRQRR-------------IEEQK 402
Query: 66 EKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERLRS 125
E+RRR + ++ ER ++++ R + LRR Q +QE + +QL+E+ +S
Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQS 462
Query: 126 KQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQVLPNENGGTPNHRPTGR 185
++ LQRQL+Q E L++ ++ Q+LP + ++ GR
Sbjct: 463 ER--LQRQLQQ--------EHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY---GR 509
Query: 186 GNN 188
G N
Sbjct: 510 GMN 512
Score = 29.3 bits (64), Expect = 2.2
Identities = 21/88 (23%), Positives = 41/88 (46%), Gaps = 7/88 (7%)
Query: 68 RRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERLRS-- 125
R + + K E LKQQ L R + +++E+Q++ R+++E+ R
Sbjct: 357 RLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRRER 416
Query: 126 -----KQQSLQRQLEQLRGLAGAAERER 148
+++ QR+LE ++ L ER +
Sbjct: 417 EQRKLQEKEQQRRLEDMQALRREEERRQ 444
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 42.4 bits (98), Expect = 2e-04
Identities = 42/183 (22%), Positives = 81/183 (44%), Gaps = 34/183 (18%)
Query: 6 SNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNEL 65
SN + L Q + ++++R+ E L +H+R++R + +
Sbjct: 364 SNSEALKQQQQLQQQQQRDPEAHIKHL--------LHQRQRR-------------IEEQK 402
Query: 66 EKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERLRS 125
E+RRR + ++ ER ++++ R + LRR Q +QE + +QL+E+ +S
Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQS 462
Query: 126 KQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQVLPNENGGTPNHRPTGR 185
++ LQRQL+Q E L++ ++ Q+LP + ++ GR
Sbjct: 463 ER--LQRQLQQ--------EHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY---GR 509
Query: 186 GNN 188
G N
Sbjct: 510 GMN 512
Score = 29.3 bits (64), Expect = 2.2
Identities = 21/88 (23%), Positives = 41/88 (46%), Gaps = 7/88 (7%)
Query: 68 RRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERLRS-- 125
R + + K E LKQQ L R + +++E+Q++ R+++E+ R
Sbjct: 357 RLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRRER 416
Query: 126 -----KQQSLQRQLEQLRGLAGAAERER 148
+++ QR+LE ++ L ER +
Sbjct: 417 EQRKLQEKEQQRRLEDMQALRREEERRQ 444
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 42.4 bits (98), Expect = 2e-04
Identities = 42/183 (22%), Positives = 81/183 (44%), Gaps = 34/183 (18%)
Query: 6 SNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNEL 65
SN + L Q + ++++R+ E L +H+R++R + +
Sbjct: 364 SNSEALKQQQQLQQQQQRDPEAHIKHL--------LHQRQRR-------------IEEQK 402
Query: 66 EKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERLRS 125
E+RRR + ++ ER ++++ R + LRR Q +QE + +QL+E+ +S
Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQS 462
Query: 126 KQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQVLPNENGGTPNHRPTGR 185
++ LQRQL+Q E L++ ++ Q+LP + ++ GR
Sbjct: 463 ER--LQRQLQQ--------EHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY---GR 509
Query: 186 GNN 188
G N
Sbjct: 510 GMN 512
Score = 29.3 bits (64), Expect = 2.2
Identities = 21/88 (23%), Positives = 41/88 (46%), Gaps = 7/88 (7%)
Query: 68 RRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERLRS-- 125
R + + K E LKQQ L R + +++E+Q++ R+++E+ R
Sbjct: 357 RLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRRER 416
Query: 126 -----KQQSLQRQLEQLRGLAGAAERER 148
+++ QR+LE ++ L ER +
Sbjct: 417 EQRKLQEKEQQRRLEDMQALRREEERRQ 444
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens]
Length = 1293
Score = 40.8 bits (94), Expect = 7e-04
Identities = 36/158 (22%), Positives = 70/158 (44%), Gaps = 16/158 (10%)
Query: 41 IHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLR 100
+ R+K+ Q Q++ R + + ++++ AQ+K Q C TLSL
Sbjct: 883 VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSL-- 940
Query: 101 RARMHIQKLEDQ------EQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLRADSL 154
IQKLE++ E++ RQ +E +++ QQ Q+Q ++L G + +
Sbjct: 941 ---AEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVS-----KPSGT 992
Query: 155 DSSGLSSERSDSDQVLPNENGGTPNHRPTGRGNNISSH 192
S L ++ ++ Q+ + + +P NN S+
Sbjct: 993 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSN 1030
Score = 35.0 bits (79), Expect = 0.040
Identities = 28/107 (26%), Positives = 52/107 (48%), Gaps = 4/107 (3%)
Query: 64 ELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERL 123
+LEK + A+L++ ER + +M + LRR + I + + +E+R R+ +E L
Sbjct: 722 QLEKAKAAKLEQ--ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEEL 779
Query: 124 --RSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQ 168
R ++++L+RQ EQ L E E + L R + ++
Sbjct: 780 ARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 826
Score = 30.8 bits (68), Expect = 0.75
Identities = 45/181 (24%), Positives = 78/181 (43%), Gaps = 20/181 (11%)
Query: 2 EPLASNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKK-----RPPQAPGAQD 56
E L + +L+ + ER+ RE E L + + R+++ R + +
Sbjct: 753 EELRRQQEEILRRQQEEERKRREEEE----LARRKQEEALRRQREQEIALRRQREEEERQ 808
Query: 57 SGRSVHNELEKRRRAQLKRCL--ERLKQQMPLGADCARYTTLSLLR----RARMHIQKLE 110
LE+RRR + +R E L++Q A AR + R R RM +
Sbjct: 809 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 868
Query: 111 ---DQEQRARQLKERLRSKQQSLQRQLEQ--LRGLAGAAERERLRADSLDSSGLSSERSD 165
++E+R R+ E R K+ QRQ +Q LR L ++++L L SS ++S+
Sbjct: 869 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 928
Query: 166 S 166
+
Sbjct: 929 T 929
Score = 30.0 bits (66), Expect = 1.3
Identities = 41/159 (25%), Positives = 63/159 (39%), Gaps = 31/159 (19%)
Query: 3 PLASNIQVLLQA-AEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRSV 61
P +Q L +A A LE+ REAE R KR + Q+ R
Sbjct: 715 PALEQLQQLEKAKAAKLEQERREAE----------------MRAKREEEERKRQEELRRQ 758
Query: 62 HNEL-----EKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRA 116
E+ E+ R+ + + L R KQ+ L R + R + ++ + QE+
Sbjct: 759 QEEILRRQQEEERKRREEEELARRKQEEAL----RRQREQEIALRRQREEEERQQQEEAL 814
Query: 117 RQLKERLRS-----KQQSLQRQLEQLRGLAGAAERERLR 150
R+L+ER R KQ+ L R+ E+ E E R
Sbjct: 815 RRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQR 853
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 40.8 bits (94), Expect = 7e-04
Identities = 36/158 (22%), Positives = 70/158 (44%), Gaps = 16/158 (10%)
Query: 41 IHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLR 100
+ R+K+ Q Q++ R + + ++++ AQ+K Q C TLSL
Sbjct: 910 VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSL-- 967
Query: 101 RARMHIQKLEDQ------EQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLRADSL 154
IQKLE++ E++ RQ +E +++ QQ Q+Q ++L G + +
Sbjct: 968 ---AEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVS-----KPSGT 1019
Query: 155 DSSGLSSERSDSDQVLPNENGGTPNHRPTGRGNNISSH 192
S L ++ ++ Q+ + + +P NN S+
Sbjct: 1020 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSN 1057
Score = 35.0 bits (79), Expect = 0.040
Identities = 28/107 (26%), Positives = 52/107 (48%), Gaps = 4/107 (3%)
Query: 64 ELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERL 123
+LEK + A+L++ ER + +M + LRR + I + + +E+R R+ +E L
Sbjct: 749 QLEKAKAAKLEQ--ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEEL 806
Query: 124 --RSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQ 168
R ++++L+RQ EQ L E E + L R + ++
Sbjct: 807 ARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 853
Score = 30.8 bits (68), Expect = 0.75
Identities = 45/181 (24%), Positives = 78/181 (43%), Gaps = 20/181 (11%)
Query: 2 EPLASNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKK-----RPPQAPGAQD 56
E L + +L+ + ER+ RE E L + + R+++ R + +
Sbjct: 780 EELRRQQEEILRRQQEEERKRREEEE----LARRKQEEALRRQREQEIALRRQREEEERQ 835
Query: 57 SGRSVHNELEKRRRAQLKRCL--ERLKQQMPLGADCARYTTLSLLR----RARMHIQKLE 110
LE+RRR + +R E L++Q A AR + R R RM +
Sbjct: 836 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 895
Query: 111 ---DQEQRARQLKERLRSKQQSLQRQLEQ--LRGLAGAAERERLRADSLDSSGLSSERSD 165
++E+R R+ E R K+ QRQ +Q LR L ++++L L SS ++S+
Sbjct: 896 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 955
Query: 166 S 166
+
Sbjct: 956 T 956
Score = 30.0 bits (66), Expect = 1.3
Identities = 41/159 (25%), Positives = 63/159 (39%), Gaps = 31/159 (19%)
Query: 3 PLASNIQVLLQA-AEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRSV 61
P +Q L +A A LE+ REAE R KR + Q+ R
Sbjct: 742 PALEQLQQLEKAKAAKLEQERREAE----------------MRAKREEEERKRQEELRRQ 785
Query: 62 HNEL-----EKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRA 116
E+ E+ R+ + + L R KQ+ L R + R + ++ + QE+
Sbjct: 786 QEEILRRQQEEERKRREEEELARRKQEEAL----RRQREQEIALRRQREEEERQQQEEAL 841
Query: 117 RQLKERLRS-----KQQSLQRQLEQLRGLAGAAERERLR 150
R+L+ER R KQ+ L R+ E+ E E R
Sbjct: 842 RRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQR 880
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 40.8 bits (94), Expect = 7e-04
Identities = 36/158 (22%), Positives = 70/158 (44%), Gaps = 16/158 (10%)
Query: 41 IHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLR 100
+ R+K+ Q Q++ R + + ++++ AQ+K Q C TLSL
Sbjct: 889 VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSL-- 946
Query: 101 RARMHIQKLEDQ------EQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLRADSL 154
IQKLE++ E++ RQ +E +++ QQ Q+Q ++L G + +
Sbjct: 947 ---AEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVS-----KPSGT 998
Query: 155 DSSGLSSERSDSDQVLPNENGGTPNHRPTGRGNNISSH 192
S L ++ ++ Q+ + + +P NN S+
Sbjct: 999 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSN 1036
Score = 35.0 bits (79), Expect = 0.040
Identities = 28/107 (26%), Positives = 52/107 (48%), Gaps = 4/107 (3%)
Query: 64 ELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERL 123
+LEK + A+L++ ER + +M + LRR + I + + +E+R R+ +E L
Sbjct: 728 QLEKAKAAKLEQ--ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEEL 785
Query: 124 --RSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQ 168
R ++++L+RQ EQ L E E + L R + ++
Sbjct: 786 ARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 832
Score = 30.8 bits (68), Expect = 0.75
Identities = 45/181 (24%), Positives = 78/181 (43%), Gaps = 20/181 (11%)
Query: 2 EPLASNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKK-----RPPQAPGAQD 56
E L + +L+ + ER+ RE E L + + R+++ R + +
Sbjct: 759 EELRRQQEEILRRQQEEERKRREEEE----LARRKQEEALRRQREQEIALRRQREEEERQ 814
Query: 57 SGRSVHNELEKRRRAQLKRCL--ERLKQQMPLGADCARYTTLSLLR----RARMHIQKLE 110
LE+RRR + +R E L++Q A AR + R R RM +
Sbjct: 815 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 874
Query: 111 ---DQEQRARQLKERLRSKQQSLQRQLEQ--LRGLAGAAERERLRADSLDSSGLSSERSD 165
++E+R R+ E R K+ QRQ +Q LR L ++++L L SS ++S+
Sbjct: 875 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 934
Query: 166 S 166
+
Sbjct: 935 T 935
Score = 30.0 bits (66), Expect = 1.3
Identities = 41/159 (25%), Positives = 63/159 (39%), Gaps = 31/159 (19%)
Query: 3 PLASNIQVLLQA-AEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRSV 61
P +Q L +A A LE+ REAE R KR + Q+ R
Sbjct: 721 PALEQLQQLEKAKAAKLEQERREAE----------------MRAKREEEERKRQEELRRQ 764
Query: 62 HNEL-----EKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRA 116
E+ E+ R+ + + L R KQ+ L R + R + ++ + QE+
Sbjct: 765 QEEILRRQQEEERKRREEEELARRKQEEAL----RRQREQEIALRRQREEEERQQQEEAL 820
Query: 117 RQLKERLRS-----KQQSLQRQLEQLRGLAGAAERERLR 150
R+L+ER R KQ+ L R+ E+ E E R
Sbjct: 821 RRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQR 859
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 40.8 bits (94), Expect = 7e-04
Identities = 36/158 (22%), Positives = 70/158 (44%), Gaps = 16/158 (10%)
Query: 41 IHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLR 100
+ R+K+ Q Q++ R + + ++++ AQ+K Q C TLSL
Sbjct: 889 VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSL-- 946
Query: 101 RARMHIQKLEDQ------EQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLRADSL 154
IQKLE++ E++ RQ +E +++ QQ Q+Q ++L G + +
Sbjct: 947 ---AEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVS-----KPSGT 998
Query: 155 DSSGLSSERSDSDQVLPNENGGTPNHRPTGRGNNISSH 192
S L ++ ++ Q+ + + +P NN S+
Sbjct: 999 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSN 1036
Score = 35.0 bits (79), Expect = 0.040
Identities = 28/107 (26%), Positives = 52/107 (48%), Gaps = 4/107 (3%)
Query: 64 ELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERL 123
+LEK + A+L++ ER + +M + LRR + I + + +E+R R+ +E L
Sbjct: 728 QLEKAKAAKLEQ--ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEEL 785
Query: 124 --RSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQ 168
R ++++L+RQ EQ L E E + L R + ++
Sbjct: 786 ARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 832
Score = 30.8 bits (68), Expect = 0.75
Identities = 45/181 (24%), Positives = 78/181 (43%), Gaps = 20/181 (11%)
Query: 2 EPLASNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKK-----RPPQAPGAQD 56
E L + +L+ + ER+ RE E L + + R+++ R + +
Sbjct: 759 EELRRQQEEILRRQQEEERKRREEEE----LARRKQEEALRRQREQEIALRRQREEEERQ 814
Query: 57 SGRSVHNELEKRRRAQLKRCL--ERLKQQMPLGADCARYTTLSLLR----RARMHIQKLE 110
LE+RRR + +R E L++Q A AR + R R RM +
Sbjct: 815 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 874
Query: 111 ---DQEQRARQLKERLRSKQQSLQRQLEQ--LRGLAGAAERERLRADSLDSSGLSSERSD 165
++E+R R+ E R K+ QRQ +Q LR L ++++L L SS ++S+
Sbjct: 875 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 934
Query: 166 S 166
+
Sbjct: 935 T 935
Score = 30.0 bits (66), Expect = 1.3
Identities = 41/159 (25%), Positives = 63/159 (39%), Gaps = 31/159 (19%)
Query: 3 PLASNIQVLLQA-AEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRSV 61
P +Q L +A A LE+ REAE R KR + Q+ R
Sbjct: 721 PALEQLQQLEKAKAAKLEQERREAE----------------MRAKREEEERKRQEELRRQ 764
Query: 62 HNEL-----EKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRA 116
E+ E+ R+ + + L R KQ+ L R + R + ++ + QE+
Sbjct: 765 QEEILRRQQEEERKRREEEELARRKQEEAL----RRQREQEIALRRQREEEERQQQEEAL 820
Query: 117 RQLKERLRS-----KQQSLQRQLEQLRGLAGAAERERLR 150
R+L+ER R KQ+ L R+ E+ E E R
Sbjct: 821 RRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQR 859
>gi|38156705 microphthalmia-associated transcription factor isoform
6 [Homo sapiens]
Length = 495
Score = 40.4 bits (93), Expect = 0.001
Identities = 31/130 (23%), Positives = 63/130 (48%), Gaps = 3/130 (2%)
Query: 33 CPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADC-A 91
CP P + +A + + HN +E+RRR + ++ L +P D
Sbjct: 256 CPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDM 315
Query: 92 RYTTLSLLRRARMHIQKLEDQEQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLRA 151
R+ ++L+ + +I+KL+ ++QRA++L+ R + + + + L +++ L A L
Sbjct: 316 RWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGL-- 373
Query: 152 DSLDSSGLSS 161
+ S+GL S
Sbjct: 374 SLIPSTGLCS 383
>gi|38156703 microphthalmia-associated transcription factor isoform
2 [Homo sapiens]
Length = 504
Score = 40.4 bits (93), Expect = 0.001
Identities = 31/130 (23%), Positives = 63/130 (48%), Gaps = 3/130 (2%)
Query: 33 CPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADC-A 91
CP P + +A + + HN +E+RRR + ++ L +P D
Sbjct: 265 CPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDM 324
Query: 92 RYTTLSLLRRARMHIQKLEDQEQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLRA 151
R+ ++L+ + +I+KL+ ++QRA++L+ R + + + + L +++ L A L
Sbjct: 325 RWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGL-- 382
Query: 152 DSLDSSGLSS 161
+ S+GL S
Sbjct: 383 SLIPSTGLCS 392
>gi|38156701 microphthalmia-associated transcription factor isoform
3 [Homo sapiens]
Length = 519
Score = 40.4 bits (93), Expect = 0.001
Identities = 31/130 (23%), Positives = 63/130 (48%), Gaps = 3/130 (2%)
Query: 33 CPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADC-A 91
CP P + +A + + HN +E+RRR + ++ L +P D
Sbjct: 280 CPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDM 339
Query: 92 RYTTLSLLRRARMHIQKLEDQEQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLRA 151
R+ ++L+ + +I+KL+ ++QRA++L+ R + + + + L +++ L A L
Sbjct: 340 RWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGL-- 397
Query: 152 DSLDSSGLSS 161
+ S+GL S
Sbjct: 398 SLIPSTGLCS 407
>gi|38156699 microphthalmia-associated transcription factor isoform
1 [Homo sapiens]
Length = 520
Score = 40.4 bits (93), Expect = 0.001
Identities = 31/130 (23%), Positives = 63/130 (48%), Gaps = 3/130 (2%)
Query: 33 CPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADC-A 91
CP P + +A + + HN +E+RRR + ++ L +P D
Sbjct: 281 CPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDM 340
Query: 92 RYTTLSLLRRARMHIQKLEDQEQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLRA 151
R+ ++L+ + +I+KL+ ++QRA++L+ R + + + + L +++ L A L
Sbjct: 341 RWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGL-- 398
Query: 152 DSLDSSGLSS 161
+ S+GL S
Sbjct: 399 SLIPSTGLCS 408
>gi|38156697 microphthalmia-associated transcription factor isoform
5 [Homo sapiens]
Length = 413
Score = 40.4 bits (93), Expect = 0.001
Identities = 31/130 (23%), Positives = 63/130 (48%), Gaps = 3/130 (2%)
Query: 33 CPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADC-A 91
CP P + +A + + HN +E+RRR + ++ L +P D
Sbjct: 174 CPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDM 233
Query: 92 RYTTLSLLRRARMHIQKLEDQEQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLRA 151
R+ ++L+ + +I+KL+ ++QRA++L+ R + + + + L +++ L A L
Sbjct: 234 RWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGL-- 291
Query: 152 DSLDSSGLSS 161
+ S+GL S
Sbjct: 292 SLIPSTGLCS 301
>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform
b [Homo sapiens]
Length = 1173
Score = 40.4 bits (93), Expect = 0.001
Identities = 36/135 (26%), Positives = 62/135 (45%), Gaps = 15/135 (11%)
Query: 64 ELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERL 123
E ++ RA L++ +L+ + ++ L R +L+++E ARQL+ERL
Sbjct: 859 EKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGA----RLQEREGEARQLRERL 914
Query: 124 RSKQQSLQRQ-------LEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQVLPN--EN 174
++ L+RQ LE+LR A ERER R + L L + + + P+
Sbjct: 915 EQERAELERQRQAYQHDLERLREAQRAVERERERLELL--RRLKKQNTAPGALPPDTLAE 972
Query: 175 GGTPNHRPTGRGNNI 189
P+H P+ G +
Sbjct: 973 AQPPSHPPSFNGEGL 987
>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
[Homo sapiens]
Length = 1015
Score = 40.4 bits (93), Expect = 0.001
Identities = 36/135 (26%), Positives = 62/135 (45%), Gaps = 15/135 (11%)
Query: 64 ELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERL 123
E ++ RA L++ +L+ + ++ L R +L+++E ARQL+ERL
Sbjct: 701 EKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGA----RLQEREGEARQLRERL 756
Query: 124 RSKQQSLQRQ-------LEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQVLPN--EN 174
++ L+RQ LE+LR A ERER R + L L + + + P+
Sbjct: 757 EQERAELERQRQAYQHDLERLREAQRAVERERERLELL--RRLKKQNTAPGALPPDTLAE 814
Query: 175 GGTPNHRPTGRGNNI 189
P+H P+ G +
Sbjct: 815 AQPPSHPPSFNGEGL 829
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 40.4 bits (93), Expect = 0.001
Identities = 34/103 (33%), Positives = 51/103 (49%), Gaps = 17/103 (16%)
Query: 48 PPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQ 107
PP P + + N L K LE + +Q L A+ LSLL R + +
Sbjct: 152 PPAGPSKVEQLQDETNHLRKE--------LESVGRQ--LQAEVENNQMLSLLNRRQE--E 199
Query: 108 KLEDQEQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLR 150
+L +QE+R R+ +ERLR +++ L Q E+LR + ERLR
Sbjct: 200 RLREQEERLREQEERLREQEERLCEQEERLR-----EQEERLR 237
Score = 35.4 bits (80), Expect = 0.030
Identities = 23/74 (31%), Positives = 39/74 (52%), Gaps = 15/74 (20%)
Query: 65 LEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERLR 124
L +R+ +L+ ERL++Q R R ++L +QE+R R+ +ERLR
Sbjct: 193 LNRRQEERLREQEERLREQE---------------ERLREQEERLCEQEERLREQEERLR 237
Query: 125 SKQQSLQRQLEQLR 138
+++ L Q E+LR
Sbjct: 238 EQEERLCEQEERLR 251
Score = 33.5 bits (75), Expect = 0.12
Identities = 19/50 (38%), Positives = 30/50 (60%), Gaps = 5/50 (10%)
Query: 101 RARMHIQKLEDQEQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLR 150
R R H ++L +QE+R + +ERLR +++ L Q E+L + ERLR
Sbjct: 249 RLREHEERLCEQEERLCEQEERLREQEERLHEQEERL-----CEQEERLR 293
Score = 31.6 bits (70), Expect = 0.44
Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 6/73 (8%)
Query: 101 RARMHIQKLEDQEQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLS 160
R R ++L +QE+R + +ERLR +++ L Q E+LR E+E + +
Sbjct: 270 RLREQEERLHEQEERLCEQEERLREQEERLCEQEERLR------EQEERLCEQEERLREQ 323
Query: 161 SERSDSDQVLPNE 173
ER + LP +
Sbjct: 324 EERLCEQEKLPGQ 336
Score = 29.6 bits (65), Expect = 1.7
Identities = 17/49 (34%), Positives = 29/49 (59%)
Query: 101 RARMHIQKLEDQEQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERL 149
R R ++L +QE+R R+ +ERL +++ L+ Q E+L +ERL
Sbjct: 291 RLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERL 339
Score = 28.9 bits (63), Expect = 2.8
Identities = 15/44 (34%), Positives = 27/44 (61%), Gaps = 5/44 (11%)
Query: 107 QKLEDQEQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLR 150
++L +QE+R + +ERL +++ L+ Q E+L + ERLR
Sbjct: 269 ERLREQEERLHEQEERLCEQEERLREQEERL-----CEQEERLR 307
>gi|46877105 upstream stimulatory factor 2 isoform 2 [Homo sapiens]
Length = 279
Score = 39.3 bits (90), Expect = 0.002
Identities = 30/106 (28%), Positives = 60/106 (56%), Gaps = 7/106 (6%)
Query: 59 RSVHNELEKRRRAQLKRCLERLKQQMP-LGADCAR--YTTLSLLRRARMHIQKLEDQEQR 115
R+ HNE+E+RRR ++ + +L + +P AD ++ + +L +A +I++L QR
Sbjct: 170 RAQHNEVERRRRDKINNWIVQLSKIIPDCNADNSKTGASKGGILSKACDYIRELRQTNQR 229
Query: 116 ARQL---KERLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSG 158
++ ERL+ + L++Q+E+L+ A R +L+ +L+ G
Sbjct: 230 MQETFKEAERLQMDNELLRQQIEELKN-ENALLRAQLQQHNLEMVG 274
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.129 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,099,170
Number of Sequences: 37866
Number of extensions: 383837
Number of successful extensions: 5334
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 207
Number of HSP's successfully gapped in prelim test: 350
Number of HSP's that attempted gapping in prelim test: 3496
Number of HSP's gapped (non-prelim): 1667
length of query: 193
length of database: 18,247,518
effective HSP length: 97
effective length of query: 96
effective length of database: 14,574,516
effective search space: 1399153536
effective search space used: 1399153536
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.