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Search of human proteins with 218563749
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH
domains 3 [Homo sapiens]
(834 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 1648 0.0
gi|187608516 centaurin, beta 2 [Homo sapiens] 912 0.0
gi|7661880 centaurin beta1 [Homo sapiens] 578 e-165
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 187 3e-47
gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain ... 187 3e-47
gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain... 187 3e-47
gi|46094081 development and differentiation enhancing factor 1 [... 185 2e-46
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 179 1e-44
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 148 2e-35
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 146 9e-35
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 144 4e-34
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 144 4e-34
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 143 6e-34
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 143 6e-34
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 143 7e-34
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 142 1e-33
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 142 1e-33
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 142 2e-33
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 141 3e-33
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 140 4e-33
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 140 4e-33
gi|208022687 GTPase regulator associated with the focal adhesion... 123 6e-28
gi|7662208 GTPase regulator associated with the focal adhesion k... 123 6e-28
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s... 116 1e-25
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens] 115 2e-25
gi|6912242 adaptor protein, phosphotyrosine interaction, PH doma... 110 5e-24
gi|4505507 oligophrenin 1 [Homo sapiens] 107 5e-23
gi|24586663 adaptor protein, phosphotyrosine interaction, PH dom... 104 4e-22
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 103 5e-22
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 103 5e-22
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 1648 bits (4268), Expect = 0.0
Identities = 834/834 (100%), Positives = 834/834 (100%)
Query: 1 MTVEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSG 60
MTVEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSG
Sbjct: 1 MTVEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSG 60
Query: 61 VRDLSQQCQGDTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKE 120
VRDLSQQCQGDTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKE
Sbjct: 61 VRDLSQQCQGDTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKE 120
Query: 121 TKKQFDKVREDLELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQA 180
TKKQFDKVREDLELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQA
Sbjct: 121 TKKQFDKVREDLELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQA 180
Query: 181 KKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKH 240
KKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKH
Sbjct: 181 KKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKH 240
Query: 241 AAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVY 300
AAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVY
Sbjct: 241 AAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVY 300
Query: 301 QKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQA 360
QKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQA
Sbjct: 301 QKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQA 360
Query: 361 SIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGD 420
SIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGD
Sbjct: 361 SIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGD 420
Query: 421 CGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVN 480
CGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVN
Sbjct: 421 CGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVN 480
Query: 481 QIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAPMAPALEAPRRWRVQKCLR 540
QIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAPMAPALEAPRRWRVQKCLR
Sbjct: 481 QIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAPMAPALEAPRRWRVQKCLR 540
Query: 541 PHSSPRAPTARRKVRLEPVLPCVAALSSVGTLDRKFRRDSLFCPDELDSLFSYFDAGAAG 600
PHSSPRAPTARRKVRLEPVLPCVAALSSVGTLDRKFRRDSLFCPDELDSLFSYFDAGAAG
Sbjct: 541 PHSSPRAPTARRKVRLEPVLPCVAALSSVGTLDRKFRRDSLFCPDELDSLFSYFDAGAAG 600
Query: 601 AGPRSLSSDSGLGGSSDGSSDVLAFGSGSVVDSVTEEEGAESEESSGEADGDTEAEAWGL 660
AGPRSLSSDSGLGGSSDGSSDVLAFGSGSVVDSVTEEEGAESEESSGEADGDTEAEAWGL
Sbjct: 601 AGPRSLSSDSGLGGSSDGSSDVLAFGSGSVVDSVTEEEGAESEESSGEADGDTEAEAWGL 660
Query: 661 ADVRELHPGLLAHRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCE 720
ADVRELHPGLLAHRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCE
Sbjct: 661 ADVRELHPGLLAHRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCE 720
Query: 721 FLLQNGADVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAA 780
FLLQNGADVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAA
Sbjct: 721 FLLQNGADVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAA 780
Query: 781 NADIVTLLRLARMAEEMREAEAAPGPPGALAGSPTELQFRRCIQEFISLHLEES 834
NADIVTLLRLARMAEEMREAEAAPGPPGALAGSPTELQFRRCIQEFISLHLEES
Sbjct: 781 NADIVTLLRLARMAEEMREAEAAPGPPGALAGSPTELQFRRCIQEFISLHLEES 834
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 912 bits (2357), Expect = 0.0
Identities = 480/808 (59%), Positives = 593/808 (73%), Gaps = 64/808 (7%)
Query: 1 MTVEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSG 60
MTV+FEEC+KDSPRFRA ++EVE DV E+E KLDKLVKLC M++ GKA+ ++ F++G
Sbjct: 3 MTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNG 62
Query: 61 VRDLSQQCQGDTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKE 120
+RDL+Q D V+ L +F+DSLQE++N+H ILFDQ QRS++ QLQ+FVKED+RKFK+
Sbjct: 63 IRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKD 122
Query: 121 TKKQFDKVREDLELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQA 180
KKQF+KV E+ E +LV+NAQ R++ HEVEEAT LT TRKCFRH+ALDYVLQINVLQ+
Sbjct: 123 AKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILTATRKCFRHIALDYVLQINVLQS 182
Query: 181 KKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKH 240
K++ EIL SMLSFM+A +FF QGY L +L PYMK L A+LD+LV+D+A EKREME+KH
Sbjct: 183 KRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKH 242
Query: 241 AAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVY 300
+ IQQ+ DFS D+SK+E++VDA +G+VMEGYLFKRASNAFKTWNRRWFSIQN+QLVY
Sbjct: 243 STIQQK----DFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVY 298
Query: 301 QKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQA 360
QKK KD TVVV+DLRLC+VK CEDIERRFCFEV+SPTKSCMLQADSEKLRQAW++AVQ
Sbjct: 299 QKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQT 358
Query: 361 SIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGD 420
SIA+AYRE D SE+LD+ +SPST S+DS +++E+ +KGES LQRVQ + GN+ C D
Sbjct: 359 SIATAYREKGDE--SEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCD 416
Query: 421 CGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVN 480
CG DPRWASINLG+ LCIECSGIHRSLGVH SKVRSLTLD+WEPELLKLMCELGN +N
Sbjct: 417 CGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVIN 476
Query: 481 QIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAPMAPALEAPRRWRVQKCLR 540
++YEA E G +KP RQ+KEA+I+ KYVE+KF+ K + +L P + QK
Sbjct: 477 RVYEANVEKMGIKKP-QPGQRQEKEAYIRAKYVERKFVDKYSI--SLSPPEQ---QKKFV 530
Query: 541 PHSSPRAPTARRKVRLEPVLPCVAALSSVGTLDRKFRRDSLFCPDELDSLFSYFDAGAAG 600
SS +R S+ S F D A
Sbjct: 531 SKSSEE------------------------------KRLSI-------SKFGPGDQVRAS 553
Query: 601 AGPRSLSSDSGLGGSSDGSSDVLAFGSGSVVDSVTEEEGAESEESSGEADGDTEAEAWGL 660
A S+DSG+ SSD + L S +S+ E EG + S
Sbjct: 554 AQSSVRSNDSGIQQSSDDGRESLP--STVSANSLYEPEGERQDSSM-------------F 598
Query: 661 ADVRELHPGLLAHRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCE 720
D + L+PGL +RA+ ++LP +A ALAHGA+VNWA++E+ TPL+QAVLGGSL+ CE
Sbjct: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCE 658
Query: 721 FLLQNGADVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAA 780
FLLQNGA+VNQRD +GR PLHHAT+LG TGQVCLFLKRGA+QHA D+E +DPL+IAV+AA
Sbjct: 659 FLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAA 718
Query: 781 NADIVTLLRLARMAEEMREAEAAPGPPG 808
NADIVTLLRLARM EEMRE+E G PG
Sbjct: 719 NADIVTLLRLARMNEEMRESEGLYGQPG 746
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 578 bits (1490), Expect = e-165
Identities = 364/820 (44%), Positives = 477/820 (58%), Gaps = 130/820 (15%)
Query: 3 VEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVR 62
++FEEC+KDSPRFRA+I+ VE +V E+E +L+KL+KL +G++E+G+ Y++ SR FV G+
Sbjct: 5 LDFEECLKDSPRFRASIELVEAEVSELETRLEKLLKLGTGLLESGRHYLAASRAFVVGIC 64
Query: 63 DLSQQCQGDTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKETK 122
DL++ + +++ECL++F SL ++ H L D Q +++QQ+Q+ VKE +R F+E +
Sbjct: 65 DLARLGPPEPMMAECLEKFTVSLNHKLDSHAELLDATQHTLQQQIQTLVKEGLRGFREAR 124
Query: 123 KQFDKVREDLELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQAKK 182
+ F + E LE +L NA+ PR R E EEA AL R +R ALDY LQINV++ K+
Sbjct: 125 RDFWRGAESLEAALTHNAEVPRRRAQEAEEAGAALRTARAGYRGRALDYALQINVIEDKR 184
Query: 183 KFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAA 242
KF+I++ +L + AQ++ FQQG+ L +L Y K+L A+L QLV++SA EKR+ME++H
Sbjct: 185 KFDIMEFVLRLVEAQATHFQQGHEELSRLSQYRKELGAQLHQLVLNSAREKRDMEQRHVL 244
Query: 243 IQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQK 302
++Q+ L + + + P G+VMEG+LFKRASNAFKTW+RRWF+IQ++QLVYQK
Sbjct: 245 LKQKELGGEEPEPSLR-----EGPGGLVMEGHLFKRASNAFKTWSRRWFTIQSNQLVYQK 299
Query: 303 KLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQASI 362
K KD +TVVVDDLRLC+VK C D ERRFCFEV+S +KSC+LQADSE+L Q WV AVQ+SI
Sbjct: 300 KYKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCLLQADSERLLQLWVSAVQSSI 359
Query: 363 ASAYRESPDSCYSERLDRT-------------ASPSTSSIDSATDTRERGVKGESVLQRV 409
ASA+ ++ RLD + S +T RE G G V Q V
Sbjct: 360 ASAFSQA-------RLDDSPRGPGQGSGHLAIGSAATLGSGGMARGREPGGVGHVVAQ-V 411
Query: 410 QSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLK 469
QSV GN+QC DC +P P WASINLGV LCI+CSGIHRSLGVH SKVRSLTLDSWEPEL+K
Sbjct: 412 QSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVK 471
Query: 470 LMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAPMAPALEA 529
LMCELGN +NQIYEA+ E +KP S SRQ+KEAWI KYVEKKFL K P
Sbjct: 472 LMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRG 531
Query: 530 PRRWRVQKCLRPHSSPRAPTARRKVRLEPVLPCVAALSSVGTLDRKFRRDSLFCPDELDS 589
R RP P P + +R P G+L K S ++L S
Sbjct: 532 GRG-------RPRGQPPVP-PKPSIRPRP-----------GSLRSKPEPPS----EDLGS 568
Query: 590 LFSYFDAGAAGAGPRSLSSDSGLGGSSDGSSDVLAFGSGSVVDSVTEEEGAESEESSGEA 649
L A P SL + +D LA GA+ +G
Sbjct: 569 LHPGALLFRASGHPPSLPT----------MADALA-------------HGADVNWVNGGQ 605
Query: 650 DGDTEAEAWGLADVRELHPGLLAHRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQ 709
D T +A A L A L +GA VN AD+ G+ PL
Sbjct: 606 DNATP-----------------LIQATAANSLLACEFLLQNGANVNQADS--AGRGPLHH 646
Query: 710 A-VLGGSLIVCEFLLQNGADVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQE 768
A +LG + + C F L+ GAD+ RDS G
Sbjct: 647 ATILGHTGLACLF-LKRGADLGARDSEG-------------------------------- 673
Query: 769 QRDPLAIAVQAANADIVTLLRLARMAEEMREAEAAPGPPG 808
RDPL IA++ ANADIVTLLRLA+ MREAEAA G G
Sbjct: 674 -RDPLTIAMETANADIVTLLRLAK----MREAEAAQGQAG 708
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 187 bits (475), Expect = 3e-47
Identities = 138/533 (25%), Positives = 233/533 (43%), Gaps = 56/533 (10%)
Query: 16 RATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDLSQQC--QGDTV 73
R T+ +E + L K+ K + +G A+V + + C + D
Sbjct: 34 RNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPD 93
Query: 74 ISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFK-ETKKQFDKVREDL 132
+ +F+ +E+ L + L S +K D++ K + KK FDK +D
Sbjct: 94 LGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDY 153
Query: 133 ELSLVR-----NAQAPRHRPHEVE----EATGALTLTRKCFRHLALDYVLQINVLQAKKK 183
E + + A H E E + R+ F+ +Y+L++N ++ KK
Sbjct: 154 ETKITKIEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKG 213
Query: 184 FEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAI 243
++L +++ + HAQ +FFQ G + L P ++ L+ +L +++ + E + I
Sbjct: 214 VDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLH------TIKQAQDEERRQLI 267
Query: 244 QQRTLLQDFSYDESKVEFDV-------------DAPSGVVMEGYLFKRASNAFKTWNRRW 290
Q R +L+ E K + + + G G L+K++ K W +R
Sbjct: 268 QLRDILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRK 327
Query: 291 FSIQNSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKL 350
S++N L + ++ L C VK + E + CF+++S ++ QA+ E+
Sbjct: 328 CSVKNGFLTISHGTANRPPAKLN-LLTCQVKT--NPEEKKCFDLISHDRTYHFQAEDEQE 384
Query: 351 RQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGE---SVLQ 407
Q W+ +Q S A ++ +T E + E ++
Sbjct: 385 CQIWMSVLQNSKEEALN-------------------NAFKGDDNTGENNIVQELTKEIIS 425
Query: 408 RVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPEL 467
VQ + GN C DCG PDP W S NLG+L CIECSGIHR LGVH S+++SLTLD
Sbjct: 426 EVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSE 485
Query: 468 LKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRK 520
L L +GN+ N+I E S KP S ++ +I KY+E+++ RK
Sbjct: 486 LLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARK 538
Score = 38.9 bits (89), Expect = 0.020
Identities = 32/124 (25%), Positives = 57/124 (45%), Gaps = 7/124 (5%)
Query: 675 AARARDLPALAAALAHGAEVN----WADAEDEGKTPL---VQAVLGGSLIVCEFLLQNGA 727
A + RD+ L A A G ++ A+ + +T L V++V SL + +FL+QN
Sbjct: 553 AVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSG 612
Query: 728 DVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTL 787
+++++ +G LH+ L + L L+ A ++ PL IA + + L
Sbjct: 613 NLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEEL 672
Query: 788 LRLA 791
L A
Sbjct: 673 LTQA 676
>gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform a [Homo sapiens]
Length = 1006
Score = 187 bits (475), Expect = 3e-47
Identities = 138/533 (25%), Positives = 233/533 (43%), Gaps = 56/533 (10%)
Query: 16 RATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDLSQQC--QGDTV 73
R T+ +E + L K+ K + +G A+V + + C + D
Sbjct: 34 RNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPD 93
Query: 74 ISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFK-ETKKQFDKVREDL 132
+ +F+ +E+ L + L S +K D++ K + KK FDK +D
Sbjct: 94 LGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDY 153
Query: 133 ELSLVR-----NAQAPRHRPHEVE----EATGALTLTRKCFRHLALDYVLQINVLQAKKK 183
E + + A H E E + R+ F+ +Y+L++N ++ KK
Sbjct: 154 ETKITKIEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKG 213
Query: 184 FEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAI 243
++L +++ + HAQ +FFQ G + L P ++ L+ +L +++ + E + I
Sbjct: 214 VDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLH------TIKQAQDEERRQLI 267
Query: 244 QQRTLLQDFSYDESKVEFDV-------------DAPSGVVMEGYLFKRASNAFKTWNRRW 290
Q R +L+ E K + + + G G L+K++ K W +R
Sbjct: 268 QLRDILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRK 327
Query: 291 FSIQNSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKL 350
S++N L + ++ L C VK + E + CF+++S ++ QA+ E+
Sbjct: 328 CSVKNGFLTISHGTANRPPAKLN-LLTCQVKT--NPEEKKCFDLISHDRTYHFQAEDEQE 384
Query: 351 RQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGE---SVLQ 407
Q W+ +Q S A ++ +T E + E ++
Sbjct: 385 CQIWMSVLQNSKEEALN-------------------NAFKGDDNTGENNIVQELTKEIIS 425
Query: 408 RVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPEL 467
VQ + GN C DCG PDP W S NLG+L CIECSGIHR LGVH S+++SLTLD
Sbjct: 426 EVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSE 485
Query: 468 LKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRK 520
L L +GN+ N+I E S KP S ++ +I KY+E+++ RK
Sbjct: 486 LLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARK 538
Score = 38.9 bits (89), Expect = 0.020
Identities = 32/124 (25%), Positives = 57/124 (45%), Gaps = 7/124 (5%)
Query: 675 AARARDLPALAAALAHGAEVN----WADAEDEGKTPL---VQAVLGGSLIVCEFLLQNGA 727
A + RD+ L A A G ++ A+ + +T L V++V SL + +FL+QN
Sbjct: 553 AVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSG 612
Query: 728 DVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTL 787
+++++ +G LH+ L + L L+ A ++ PL IA + + L
Sbjct: 613 NLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEEL 672
Query: 788 LRLA 791
L A
Sbjct: 673 LTQA 676
>gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform a [Homo sapiens]
Length = 903
Score = 187 bits (475), Expect = 3e-47
Identities = 147/531 (27%), Positives = 236/531 (44%), Gaps = 32/531 (6%)
Query: 13 PRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDL--SQQCQG 70
PR+R E + +A L ++ K + +G +V + V L S Q
Sbjct: 32 PRYRGAALAREEILEGDQAILQRIKKAVRAIHSSGLGHVENEEQYREAVESLGNSHLSQN 91
Query: 71 DTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKE-TKKQFDKVR 129
+S A +EV L V L S +K +R ++ +KKQ +K
Sbjct: 92 SHELSTGFLNLAVFTREVAALFKNLIQNLNNIVSFPLDSLMKGQLRDGRQDSKKQLEKAW 151
Query: 130 EDLELSLVR------NAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQAKKK 183
+D E + + A+ P EV + + R+ F+ +Y+L+ Q K+
Sbjct: 152 KDYEAKMAKLEKERDRARVTGGIPGEVAQD---MQRERRIFQLHMCEYLLKAGESQMKQG 208
Query: 184 FEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREM----ERK 239
+ L S++ F HAQ +FFQ G+ L P+++KLAA + L E +++ +
Sbjct: 209 PDFLQSLIKFFHAQHNFFQDGWKAAQSLFPFIEKLAASVHALHQAQEDELQKLTQLRDSL 268
Query: 240 HAAIQQRTLLQDFSYDESKVEFDV-----DAPSGVVMEGYLFKRASNAFKTWNRRWFSIQ 294
+Q + + S S + + + G G+L+K++ + W +R ++
Sbjct: 269 RGTLQLESREEHLSRKNSGCGYSIHQHQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVK 328
Query: 295 NSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAW 354
L + V + L C V+P + E + CF++++ ++ QA+ E +AW
Sbjct: 329 YGCLTISHSTINRPPVKLT-LLTCQVRP--NPEEKKCFDLVTHNRTYHFQAEDEHECEAW 385
Query: 355 VQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAG 414
V +Q S D S S S SA E + ++ V+S G
Sbjct: 386 VSVLQ--------NSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLIAEVKSRPG 437
Query: 415 NSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCEL 474
NSQC DCG DP W S NLGVL CI+CSG+HR LGV S+++SLTLD P L L +
Sbjct: 438 NSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPSELLLALNM 497
Query: 475 GNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAPMAP 525
GN++ N++ EAQ G KP+A S + +I KYVE +F R+ P
Sbjct: 498 GNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCTPEP 548
Score = 34.7 bits (78), Expect = 0.38
Identities = 29/121 (23%), Positives = 54/121 (44%), Gaps = 7/121 (5%)
Query: 679 RDLPALAAALAHGAEVNWADAEDEGKTP-------LVQAVLGGSLIVCEFLLQNGADVNQ 731
RDL ++ A A+G + + + P V+ SL + +F++QNG ++
Sbjct: 558 RDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPLVDFIIQNGGHLDA 617
Query: 732 RDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTLLRLA 791
+ + G LH+A L + + L LK A +++ L IA + + + LL A
Sbjct: 618 KAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIARKKHHKECEELLEQA 677
Query: 792 R 792
+
Sbjct: 678 Q 678
>gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
Length = 1129
Score = 185 bits (469), Expect = 2e-46
Identities = 138/523 (26%), Positives = 239/523 (45%), Gaps = 39/523 (7%)
Query: 16 RATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDLSQQ--CQGDTV 73
R T+ +E + + L K+ K + +G+ +V + + + +
Sbjct: 54 RNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPD 113
Query: 74 ISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFK-ETKKQFDKVREDL 132
+ +F+ +E+ L +V L S +K D++ K + KK FDK +D
Sbjct: 114 LGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDY 173
Query: 133 ELSLVRNAQAPRHRPHEV----EEATGA-----LTLTRKCFRHLALDYVLQINVLQAKKK 183
E + + R + E TGA + R+ F+ +Y++++N ++ KK
Sbjct: 174 ETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKG 233
Query: 184 FEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAI 243
++L +++ + HAQ +FFQ G +L Y++KLAA+L + EK+++ I
Sbjct: 234 VDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLI 293
Query: 244 QQRTLLQDFSYDESKV------EFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQ 297
+ L +S+ + + G +GYL K++ K W RR S++N
Sbjct: 294 KSSLQLDQKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGI 353
Query: 298 LVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQA 357
L + ++ L C VKP + E + F+++S ++ QA+ E+ AW+
Sbjct: 354 LTISHATSNRQPAKLN-LLTCQVKP--NAEDKKSFDLISHNRTYHFQAEDEQDYVAWI-- 408
Query: 358 VQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQ 417
S S + + S +S++ T +++++ VQ + GN
Sbjct: 409 ------SVLTNSKEEALTMAFRGEQSAGENSLEDLT---------KAIIEDVQRLPGNDI 453
Query: 418 CGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNS 477
C DCG +P W S NLG+L CIECSGIHR +GVH S+++SL LD L L +GN+
Sbjct: 454 CCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNN 513
Query: 478 AVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRK 520
+ N I EA + S KPT SS ++ +I KYV+ +F RK
Sbjct: 514 SFNDIMEANLP-SPSPKPTPSSDMTVRKEYITAKYVDHRFSRK 555
Score = 34.7 bits (78), Expect = 0.38
Identities = 32/124 (25%), Positives = 57/124 (45%), Gaps = 6/124 (4%)
Query: 675 AARARDLPALAAALAHGAEVN---WADAEDEGKTPLVQAVLGG---SLIVCEFLLQNGAD 728
A ++RDL AL A G E+ ++ G+T L AV SL + +FL+QN +
Sbjct: 570 AIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGN 629
Query: 729 VNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTLL 788
++++ + G LH+ ++ + + L L+ ++Q L IA + LL
Sbjct: 630 LDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCEDLL 689
Query: 789 RLAR 792
A+
Sbjct: 690 SQAK 693
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 179 bits (453), Expect = 1e-44
Identities = 145/524 (27%), Positives = 229/524 (43%), Gaps = 27/524 (5%)
Query: 13 PRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDL--SQQCQG 70
PR+R E + +A L ++ K + +G +V + V L S Q
Sbjct: 32 PRYRGAALAREEILEGDQAILQRIKKAVRAIHSSGLGHVENEEQYREAVESLGNSHLSQN 91
Query: 71 DTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKETKKQFDKVRE 130
+S A +EV L V L S +K +R ++ R
Sbjct: 92 SHELSTGFLNLAVFTREVAALFKNLIQNLNNIVSFPLDSLMKGQLRDGRQASLSLGS-RA 150
Query: 131 DLELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQAKKKFEILDSM 190
LE R A+ P EV + + R+ F+ +Y+L+ Q K+ + L S+
Sbjct: 151 KLEKERDR-ARVTGGIPGEVAQD---MQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSL 206
Query: 191 LSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREM----ERKHAAIQQR 246
+ F HAQ +FFQ G+ L P+++KLAA + L E +++ + +Q
Sbjct: 207 IKFFHAQHNFFQDGWKAAQSLFPFIEKLAASVHALHQAQEDELQKLTQLRDSLRGTLQLE 266
Query: 247 TLLQDFSYDESKVEFDV-----DAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQ 301
+ + S S + + + G G+L+K++ + W +R ++ L
Sbjct: 267 SREEHLSRKNSGCGYSIHQHQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTIS 326
Query: 302 KKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQAS 361
+ V + L C V+P + E + CF++++ ++ QA+ E +AWV +Q
Sbjct: 327 HSTINRPPVKLT-LLTCQVRP--NPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQ-- 381
Query: 362 IASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDC 421
S D S S S SA E + ++ V+S GNSQC DC
Sbjct: 382 ------NSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLIAEVKSRPGNSQCCDC 435
Query: 422 GQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQ 481
G DP W S NLGVL CI+CSG+HR LGV S+++SLTLD P L L +GN++ N+
Sbjct: 436 GAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPSELLLALNMGNTSFNE 495
Query: 482 IYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAPMAP 525
+ EAQ G KP+A S + +I KYVE +F R+ P
Sbjct: 496 VMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCTPEP 539
Score = 34.7 bits (78), Expect = 0.38
Identities = 29/121 (23%), Positives = 54/121 (44%), Gaps = 7/121 (5%)
Query: 679 RDLPALAAALAHGAEVNWADAEDEGKTP-------LVQAVLGGSLIVCEFLLQNGADVNQ 731
RDL ++ A A+G + + + P V+ SL + +F++QNG ++
Sbjct: 549 RDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPLVDFIIQNGGHLDA 608
Query: 732 RDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTLLRLA 791
+ + G LH+A L + + L LK A +++ L IA + + + LL A
Sbjct: 609 KAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIARKKHHKECEELLEQA 668
Query: 792 R 792
+
Sbjct: 669 Q 669
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 148 bits (374), Expect = 2e-35
Identities = 91/223 (40%), Positives = 127/223 (56%), Gaps = 26/223 (11%)
Query: 301 QKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPT-KSCMLQADSEKLRQAWVQAVQ 359
+K LK T + D L S E+ E +F ++S T ++C +A + + R AWVQA+Q
Sbjct: 248 KKHLKKKSTNNLKDDGLSST--AEEEEEKFM--IVSVTGQTCHFKATTYEERDAWVQAIQ 303
Query: 360 ASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCG 419
+ I ++ + SC S S S S + S ++ LQ +Q++ GNS C
Sbjct: 304 SQILASLQ----SCES-------SKSKSQLTSQSEAM--------ALQSIQNMRGNSHCV 344
Query: 420 DCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAV 479
DC +P+WAS+NLGVL+CIECSGIHRSLG S+VRSL LD W EL K+M +GN
Sbjct: 345 DCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 404
Query: 480 NQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAP 522
N I+E + G KP+ S+R++KE WI+ KY K FL P
Sbjct: 405 NSIWEGSSQ--GQTKPSIESTREEKERWIRSKYEHKLFLAPLP 445
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 665 ELHPGLLAHRAARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFL 722
EL G RA DL LAHG+ EVN E +G T L A G++++ + L
Sbjct: 448 ELSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLL 507
Query: 723 LQNGADVNQRDSRGRAPLHHA 743
+ G DV RD+ G L +A
Sbjct: 508 IWYGVDVMARDAHGNTALTYA 528
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 146 bits (368), Expect = 9e-35
Identities = 82/192 (42%), Positives = 114/192 (59%), Gaps = 22/192 (11%)
Query: 332 FEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSID 390
F ++S T ++ +A + + R AWVQA+Q+ I ++ + SC S S S S +
Sbjct: 388 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQ----SCES-------SKSKSQLT 436
Query: 391 SATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGV 450
S ++ LQ +Q++ GN+ C DC +P+WAS+NLGVL+CIECSGIHRSLG
Sbjct: 437 SQSEAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGT 488
Query: 451 HCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKD 510
S+VRSL LD W EL K+M +GN N I+E + G KPT S+R++KE WI+
Sbjct: 489 RLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQ--GRTKPTEKSTREEKERWIRS 546
Query: 511 KYVEKKFLRKAP 522
KY EK FL P
Sbjct: 547 KYEEKLFLAPLP 558
Score = 42.4 bits (98), Expect = 0.002
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 665 ELHPGLLAHRAARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFL 722
EL G RA DL LAHG+ EVN E +G T L A G++++ + L
Sbjct: 561 ELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLL 620
Query: 723 LQNGADVNQRDSRGRAPLHHA 743
+ G DV RD+ G L +A
Sbjct: 621 IWYGVDVMARDAHGNTALTYA 641
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 144 bits (362), Expect = 4e-34
Identities = 81/192 (42%), Positives = 113/192 (58%), Gaps = 22/192 (11%)
Query: 332 FEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSID 390
F ++S T ++ +A + + R AWVQA+Q+ I ++ + SC S S S S +
Sbjct: 388 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQ----SCES-------SKSKSQLT 436
Query: 391 SATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGV 450
S + LQ +Q++ GN+ C DC +P+WAS+NLGVL+CIECSGIHRSLG
Sbjct: 437 SQSKAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGT 488
Query: 451 HCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKD 510
S+VRSL LD W EL K+M +GN N I+E + G KP+ S+R++KE WI+
Sbjct: 489 RLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQ--GQTKPSEKSTREEKERWIRS 546
Query: 511 KYVEKKFLRKAP 522
KY EK FL P
Sbjct: 547 KYEEKLFLAPLP 558
Score = 42.4 bits (98), Expect = 0.002
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 665 ELHPGLLAHRAARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFL 722
EL G RA DL LAHG+ EVN E +G T L A G++++ + L
Sbjct: 561 ELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLL 620
Query: 723 LQNGADVNQRDSRGRAPLHHA 743
+ G DV RD+ G L +A
Sbjct: 621 IWYGVDVMARDAHGNTALTYA 641
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 144 bits (362), Expect = 4e-34
Identities = 81/192 (42%), Positives = 114/192 (59%), Gaps = 22/192 (11%)
Query: 332 FEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSID 390
F ++S T ++ +A + + R AWVQA+Q+ I ++ + SC S S S S +
Sbjct: 411 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQ----SCES-------SKSKSQLT 459
Query: 391 SATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGV 450
S ++ LQ +Q++ GN+ C DC +P+WAS+NLGVL+CIECSGIHRSLG
Sbjct: 460 SQSEAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGP 511
Query: 451 HCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKD 510
H S+VRSL LD W EL K+M + N N I+E + G KP+ S+R++KE WI+
Sbjct: 512 HLSRVRSLELDDWPVELRKVMSSIVNDLANSIWEGSSQ--GQTKPSEKSTREEKERWIRS 569
Query: 511 KYVEKKFLRKAP 522
KY EK FL P
Sbjct: 570 KYEEKLFLAPLP 581
Score = 42.4 bits (98), Expect = 0.002
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 665 ELHPGLLAHRAARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFL 722
EL G RA DL LAHG+ EVN E +G T L A G++++ + L
Sbjct: 584 ELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLL 643
Query: 723 LQNGADVNQRDSRGRAPLHHA 743
+ G DV RD+ G L +A
Sbjct: 644 IWYGVDVMARDAHGNTALTYA 664
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 143 bits (361), Expect = 6e-34
Identities = 79/200 (39%), Positives = 118/200 (59%), Gaps = 22/200 (11%)
Query: 324 EDIERRFCFEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTA 382
E+ E F F ++S T ++ +A + + R AWVQA+++ I ++ + SC S
Sbjct: 495 EEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQ----SCES------- 543
Query: 383 SPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECS 442
S + S + S ++ LQ ++++ GNS C DC +P WAS+NLG L+CIECS
Sbjct: 544 SKNKSRLTSQSEAM--------ALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECS 595
Query: 443 GIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQ 502
GIHR+LG H S+VRSL LD W EL+K+M +GN N ++E + G KP+ S+R+
Sbjct: 596 GIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQ--GRTKPSVDSTRE 653
Query: 503 DKEAWIKDKYVEKKFLRKAP 522
+KE WI+ KY +K FL P
Sbjct: 654 EKERWIRAKYEQKLFLAPLP 673
Score = 44.3 bits (103), Expect = 5e-04
Identities = 29/81 (35%), Positives = 40/81 (49%), Gaps = 2/81 (2%)
Query: 665 ELHPGLLAHRAARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFL 722
EL G RA DL LAHG+ EVN E +G+T L A G++++ + L
Sbjct: 676 ELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLL 735
Query: 723 LQNGADVNQRDSRGRAPLHHA 743
+ G DV RD+ G L +A
Sbjct: 736 IWYGVDVTARDAHGNTALAYA 756
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 143 bits (361), Expect = 6e-34
Identities = 79/200 (39%), Positives = 118/200 (59%), Gaps = 22/200 (11%)
Query: 324 EDIERRFCFEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTA 382
E+ E F F ++S T ++ +A + + R AWVQA+++ I ++ + SC S
Sbjct: 548 EEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQ----SCES------- 596
Query: 383 SPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECS 442
S + S + S ++ LQ ++++ GNS C DC +P WAS+NLG L+CIECS
Sbjct: 597 SKNKSRLTSQSEAM--------ALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECS 648
Query: 443 GIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQ 502
GIHR+LG H S+VRSL LD W EL+K+M +GN N ++E + G KP+ S+R+
Sbjct: 649 GIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQ--GRTKPSVDSTRE 706
Query: 503 DKEAWIKDKYVEKKFLRKAP 522
+KE WI+ KY +K FL P
Sbjct: 707 EKERWIRAKYEQKLFLAPLP 726
Score = 44.3 bits (103), Expect = 5e-04
Identities = 29/81 (35%), Positives = 40/81 (49%), Gaps = 2/81 (2%)
Query: 665 ELHPGLLAHRAARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFL 722
EL G RA DL LAHG+ EVN E +G+T L A G++++ + L
Sbjct: 729 ELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLL 788
Query: 723 LQNGADVNQRDSRGRAPLHHA 743
+ G DV RD+ G L +A
Sbjct: 789 IWYGVDVTARDAHGNTALAYA 809
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 143 bits (360), Expect = 7e-34
Identities = 80/192 (41%), Positives = 113/192 (58%), Gaps = 22/192 (11%)
Query: 332 FEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSID 390
F ++S T ++ +A + + R AWVQA+Q+ I ++ + SC S S S S +
Sbjct: 388 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQ----SCES-------SKSKSQLT 436
Query: 391 SATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGV 450
S ++ LQ +Q++ GN+ C DC +P+WAS+NLGVL+CIECSGIH SLG
Sbjct: 437 SQSEAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGT 488
Query: 451 HCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKD 510
S+VRSL LD W EL K+M +GN N I+E + G KP+ S+R++KE WI+
Sbjct: 489 RLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQ--GQTKPSEKSTREEKERWIRS 546
Query: 511 KYVEKKFLRKAP 522
KY EK FL P
Sbjct: 547 KYEEKLFLAPLP 558
Score = 39.3 bits (90), Expect = 0.015
Identities = 25/71 (35%), Positives = 35/71 (49%), Gaps = 2/71 (2%)
Query: 675 AARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQR 732
A DL LAHG+ EVN E +G T L A G++++ + L+ G DV R
Sbjct: 571 ATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMAR 630
Query: 733 DSRGRAPLHHA 743
D+ G L +A
Sbjct: 631 DAHGNTALTYA 641
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 142 bits (359), Expect = 1e-33
Identities = 80/192 (41%), Positives = 113/192 (58%), Gaps = 22/192 (11%)
Query: 332 FEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSID 390
F ++S T ++ +A + + R AWVQA+Q+ I ++ + SC S S S S +
Sbjct: 411 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQ----SCKS-------SKSKSQLT 459
Query: 391 SATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGV 450
S ++ LQ +Q++ GN+ C DC +P+WAS+NLGVL+CIECSGIHRS G
Sbjct: 460 SQSEAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGT 511
Query: 451 HCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKD 510
S+VRSL LD W EL K+M +GN N I+E + G KP+ S+R++KE WI+
Sbjct: 512 RLSRVRSLELDDWPVELRKVMSSIGNELANSIWEGSSQ--GQTKPSIKSTREEKEWWIRS 569
Query: 511 KYVEKKFLRKAP 522
KY EK FL P
Sbjct: 570 KYEEKLFLAPLP 581
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 142 bits (359), Expect = 1e-33
Identities = 80/192 (41%), Positives = 113/192 (58%), Gaps = 22/192 (11%)
Query: 332 FEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSID 390
F ++S T ++ +A + + R AWVQA+Q+ I ++ + SC S S S S +
Sbjct: 411 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQ----SCKS-------SKSKSQLT 459
Query: 391 SATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGV 450
S ++ LQ +Q++ GN+ C DC +P+WAS+NLGVL+CIECSGIHRS G
Sbjct: 460 SQSEAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGT 511
Query: 451 HCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKD 510
S+VRSL LD W EL K+M +GN N I+E + G KP+ S+R++KE WI+
Sbjct: 512 RLSRVRSLELDDWPVELRKVMSSIGNELANSIWEGSSQ--GQTKPSIKSTREEKEWWIRS 569
Query: 511 KYVEKKFLRKAP 522
KY EK FL P
Sbjct: 570 KYEEKLFLAPLP 581
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 142 bits (357), Expect = 2e-33
Identities = 82/201 (40%), Positives = 112/201 (55%), Gaps = 24/201 (11%)
Query: 324 EDIERRFCFEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTA 382
E+ E F F V+S T ++ +A + + R+ WVQ+VQA I +
Sbjct: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILA------------------ 642
Query: 383 SPSTSSIDSATDTRERGVKGESV-LQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIEC 441
S SA D G + ++ +Q V++V GNS C DC P+P WAS+NLG L+CIEC
Sbjct: 643 --SLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIEC 700
Query: 442 SGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSR 501
SGIHR LG H S+VRSL LD W PELL +M +GN+ N ++E G KP + R
Sbjct: 701 SGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGAL--GGYSKPGPDACR 758
Query: 502 QDKEAWIKDKYVEKKFLRKAP 522
++KE WI+ KY +K FL P
Sbjct: 759 EEKERWIRAKYEQKLFLAPLP 779
Score = 43.9 bits (102), Expect = 6e-04
Identities = 28/88 (31%), Positives = 43/88 (48%), Gaps = 2/88 (2%)
Query: 674 RAARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQ 731
RA DL L LAHG+ EVN + +G+T L + +++ + L+ G DV
Sbjct: 791 RAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRS 850
Query: 732 RDSRGRAPLHHATLLGRTGQVCLFLKRG 759
RD+RG PL +A G + ++ G
Sbjct: 851 RDARGLTPLAYARRAGSQECADILIQHG 878
Score = 30.0 bits (66), Expect = 9.3
Identities = 24/86 (27%), Positives = 41/86 (47%), Gaps = 4/86 (4%)
Query: 707 LVQAVLGGSLIVCEFLLQNGA--DVNQR--DSRGRAPLHHATLLGRTGQVCLFLKRGADQ 762
L++AV+ L + LL +G+ +VN+ D GR LH ++ + L + G D
Sbjct: 789 LLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDV 848
Query: 763 HALDQEQRDPLAIAVQAANADIVTLL 788
+ D PLA A +A + + +L
Sbjct: 849 RSRDARGLTPLAYARRAGSQECADIL 874
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 141 bits (355), Expect = 3e-33
Identities = 80/192 (41%), Positives = 113/192 (58%), Gaps = 22/192 (11%)
Query: 332 FEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSID 390
F ++S T ++ +A + + R AWVQA+Q+ I ++ + SC S S S S +
Sbjct: 411 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQ----SCES-------SKSKSQLT 459
Query: 391 SATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGV 450
S ++ LQ +Q++ GN+ C D +P+WAS+NLGVL+CIECSGIHRSLG
Sbjct: 460 SQSEAM--------ALQSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGT 511
Query: 451 HCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKD 510
S+VRSL LD W EL K+M +GN N I+E + G KP+ S+R++KE WI+
Sbjct: 512 RLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQ--GQTKPSVKSTREEKERWIRS 569
Query: 511 KYVEKKFLRKAP 522
KY EK FL P
Sbjct: 570 KYEEKLFLAPLP 581
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 665 ELHPGLLAHRAARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFL 722
EL G RA DL LAHG+ EVN E +G T L A G++++ + L
Sbjct: 584 ELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLL 643
Query: 723 LQNGADVNQRDSRGRAPLHHA 743
+ G DV RD+ G L +A
Sbjct: 644 IWYGVDVMARDAHGNTALTYA 664
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 140 bits (354), Expect = 4e-33
Identities = 79/203 (38%), Positives = 120/203 (59%), Gaps = 24/203 (11%)
Query: 327 ERRFCFEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPS 385
E F F ++S T ++ +A S + R AWVQA+++ I ++ + C S
Sbjct: 873 EENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQ----CCES---------- 918
Query: 386 TSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIH 445
S + TD++ V +Q +++ GNS C DCG P+P WAS+NLG L+CIECSGIH
Sbjct: 919 -SKVKLRTDSQSEAV----AIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIH 973
Query: 446 RSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKE 505
R+LG H S+VRSL LD W EL ++ +GN N+++E+ G KP+ SSR+++E
Sbjct: 974 RNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRA--KPSRDSSREERE 1031
Query: 506 AWIKDKYVEKKFLRKAPMAPALE 528
+WI+ KY + FL AP++ + E
Sbjct: 1032 SWIRAKYEQLLFL--APLSTSEE 1052
Score = 36.6 bits (83), Expect = 0.099
Identities = 38/137 (27%), Positives = 61/137 (44%), Gaps = 20/137 (14%)
Query: 630 VVDSVTEEEGAESEESSGEADGDTEAEAWGLADVREL----------HP-GLLAHRAARA 678
V +S T S +SS E E E+W A +L P G A +A
Sbjct: 1010 VWESDTRGRAKPSRDSSRE-----ERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQA 1064
Query: 679 RDLPALAAALAHGAE--VNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSRG 736
+D+ + LAH ++ + + + ++PL A +++ + LL GADV RD++G
Sbjct: 1065 QDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQG 1124
Query: 737 RAPLHHATLLGRTGQVC 753
R L +A G Q+C
Sbjct: 1125 RTALFYARQAG--SQLC 1139
Score = 30.4 bits (67), Expect = 7.1
Identities = 25/88 (28%), Positives = 37/88 (42%), Gaps = 10/88 (11%)
Query: 728 DVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTL 787
D + D + R+PLH A L L L GAD A D + R L A QA
Sbjct: 1083 DTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAG------- 1135
Query: 788 LRLARMAEEMREAEAAPGPPGALAGSPT 815
+++ ++ PG G+ A +P+
Sbjct: 1136 ---SQLCADILLQHGCPGEGGSAATTPS 1160
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 140 bits (354), Expect = 4e-33
Identities = 79/203 (38%), Positives = 120/203 (59%), Gaps = 24/203 (11%)
Query: 327 ERRFCFEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPS 385
E F F ++S T ++ +A S + R AWVQA+++ I ++ + C S
Sbjct: 517 EENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQ----CCES---------- 562
Query: 386 TSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIH 445
S + TD++ V +Q +++ GNS C DCG P+P WAS+NLG L+CIECSGIH
Sbjct: 563 -SKVKLRTDSQSEAV----AIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIH 617
Query: 446 RSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKE 505
R+LG H S+VRSL LD W EL ++ +GN N+++E+ G KP+ SSR+++E
Sbjct: 618 RNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRA--KPSRDSSREERE 675
Query: 506 AWIKDKYVEKKFLRKAPMAPALE 528
+WI+ KY + FL AP++ + E
Sbjct: 676 SWIRAKYEQLLFL--APLSTSEE 696
Score = 36.6 bits (83), Expect = 0.099
Identities = 38/137 (27%), Positives = 61/137 (44%), Gaps = 20/137 (14%)
Query: 630 VVDSVTEEEGAESEESSGEADGDTEAEAWGLADVREL----------HP-GLLAHRAARA 678
V +S T S +SS E E E+W A +L P G A +A
Sbjct: 654 VWESDTRGRAKPSRDSSRE-----ERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQA 708
Query: 679 RDLPALAAALAHGAE--VNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSRG 736
+D+ + LAH ++ + + + ++PL A +++ + LL GADV RD++G
Sbjct: 709 QDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQG 768
Query: 737 RAPLHHATLLGRTGQVC 753
R L +A G Q+C
Sbjct: 769 RTALFYARQAG--SQLC 783
Score = 30.4 bits (67), Expect = 7.1
Identities = 25/88 (28%), Positives = 37/88 (42%), Gaps = 10/88 (11%)
Query: 728 DVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTL 787
D + D + R+PLH A L L L GAD A D + R L A QA
Sbjct: 727 DTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAG------- 779
Query: 788 LRLARMAEEMREAEAAPGPPGALAGSPT 815
+++ ++ PG G+ A +P+
Sbjct: 780 ---SQLCADILLQHGCPGEGGSAATTPS 804
>gi|208022687 GTPase regulator associated with the focal adhesion
kinase pp125 isoform b [Homo sapiens]
Length = 759
Score = 123 bits (309), Expect = 6e-28
Identities = 113/451 (25%), Positives = 196/451 (43%), Gaps = 45/451 (9%)
Query: 3 VEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVR 62
+EF +C DSP FR T+ E ++ + + +L+K ++ A K S R F +
Sbjct: 6 LEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLN 65
Query: 63 DLSQQCQGDT------VISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVR 116
+ QC GD I+ LQ FA L+ + + + + + A + L+ F KE +
Sbjct: 66 EFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIG 125
Query: 117 KFKETKKQFDKVREDLELSLVRNAQ-APRHRPHEVEEATGALTLTRKCFRHLALDYVLQI 175
KE KK++DK E L ++ + + + +++EA + L R+ F ++L+YV ++
Sbjct: 126 AAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKV 185
Query: 176 NVLQAKKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKRE 235
+Q +K FE ++ +L+F+ +F+ GY L + QL I +
Sbjct: 186 QEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFK-------TQLTISIQNTRNR 238
Query: 236 MERKHAAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFKT-WNRRWFSIQ 294
E + ++ +L++ E+ +E +P MEGYL+ + F T W + +
Sbjct: 239 FEGTRSEVE--SLMKKMK--ENPLEHKTISP--YTMEGYLYVQEKRHFGTSWVKHY---- 288
Query: 295 NSQLVYQKKLKDALTVVVDD-------------LRLCSVKPCEDIERRFCFEVLSPTKS- 340
YQ+ K V D L+ C+ + + IE+RFCF+V + +
Sbjct: 289 ---CTYQRDSKQITMVPFDQKSGGKGGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPG 345
Query: 341 -CMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERG 399
+QA SE+ R+ W++A+ Y + DS SE + S S I E
Sbjct: 346 VITMQALSEEDRRLWMEAMDGR-EPVYNSNKDS-QSEGTAQLDSIGFSIIRKCIHAVETR 403
Query: 400 VKGESVLQRVQSVAGNSQCGDCGQPDPRWAS 430
E L R+ V Q DP+ AS
Sbjct: 404 GINEQGLYRIVGVNSRVQKLLSVLMDPKTAS 434
>gi|7662208 GTPase regulator associated with the focal adhesion
kinase pp125 isoform a [Homo sapiens]
Length = 814
Score = 123 bits (309), Expect = 6e-28
Identities = 113/451 (25%), Positives = 196/451 (43%), Gaps = 45/451 (9%)
Query: 3 VEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVR 62
+EF +C DSP FR T+ E ++ + + +L+K ++ A K S R F +
Sbjct: 6 LEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLN 65
Query: 63 DLSQQCQGDT------VISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVR 116
+ QC GD I+ LQ FA L+ + + + + + A + L+ F KE +
Sbjct: 66 EFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIG 125
Query: 117 KFKETKKQFDKVREDLELSLVRNAQ-APRHRPHEVEEATGALTLTRKCFRHLALDYVLQI 175
KE KK++DK E L ++ + + + +++EA + L R+ F ++L+YV ++
Sbjct: 126 AAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKV 185
Query: 176 NVLQAKKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKRE 235
+Q +K FE ++ +L+F+ +F+ GY L + QL I +
Sbjct: 186 QEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFK-------TQLTISIQNTRNR 238
Query: 236 MERKHAAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFKT-WNRRWFSIQ 294
E + ++ +L++ E+ +E +P MEGYL+ + F T W + +
Sbjct: 239 FEGTRSEVE--SLMKKMK--ENPLEHKTISP--YTMEGYLYVQEKRHFGTSWVKHY---- 288
Query: 295 NSQLVYQKKLKDALTVVVDD-------------LRLCSVKPCEDIERRFCFEVLSPTKS- 340
YQ+ K V D L+ C+ + + IE+RFCF+V + +
Sbjct: 289 ---CTYQRDSKQITMVPFDQKSGGKGGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPG 345
Query: 341 -CMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERG 399
+QA SE+ R+ W++A+ Y + DS SE + S S I E
Sbjct: 346 VITMQALSEEDRRLWMEAMDGR-EPVYNSNKDS-QSEGTAQLDSIGFSIIRKCIHAVETR 403
Query: 400 VKGESVLQRVQSVAGNSQCGDCGQPDPRWAS 430
E L R+ V Q DP+ AS
Sbjct: 404 GINEQGLYRIVGVNSRVQKLLSVLMDPKTAS 434
>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
sapiens]
Length = 874
Score = 116 bits (290), Expect = 1e-25
Identities = 101/379 (26%), Positives = 170/379 (44%), Gaps = 36/379 (9%)
Query: 2 TVEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGV 61
T+EF + DSP FR + E ++ + +L+K S ++ A + + F +
Sbjct: 5 TLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSL 64
Query: 62 RDLSQQCQGDTV------ISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDV 115
+D +C GD I++ L+ FA L V L A + L+ F KE +
Sbjct: 65 QDFQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQI 124
Query: 116 RKFKETKKQFDKVREDLELSLVR--NAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVL 173
K+ KK+FDK E L + N A + H ++EA + + F +L+YV
Sbjct: 125 GAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESH-LQEADTQIDREHQNFYEASLEYVF 183
Query: 174 QINVLQAKKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEK 233
+I +Q KKKFE ++ +LSF+ +F+ +GY L + PY ++L L + +
Sbjct: 184 KIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFESTR 243
Query: 234 REMERKHAAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFK-TWNRRW-- 290
+E+ER + QR D PS MEGYL+ + TW + +
Sbjct: 244 QEVER----LMQRM---------KSANQDYRPPSQWTMEGYLYVQEKRPLGFTWIKHYCT 290
Query: 291 -------FSIQNSQLVYQKKLKDALTVVVD--DLRLCSVKPCEDIERRFCF--EVLSPTK 339
F++ S++ K+ +T + L+ C + + I++RFCF EV+
Sbjct: 291 YDKGSKTFTMSVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHG 350
Query: 340 SCMLQADSEKLRQAWVQAV 358
LQA SE R+ W++A+
Sbjct: 351 IITLQAFSEANRKLWLEAM 369
>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
Length = 786
Score = 115 bits (288), Expect = 2e-25
Identities = 114/443 (25%), Positives = 192/443 (43%), Gaps = 49/443 (11%)
Query: 3 VEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVR 62
+EF +C DSP FR I E ++ + +L+K ++ A K+ R F +R
Sbjct: 6 LEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKFAHSLR 65
Query: 63 DLSQQCQGDTV------ISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVR 116
D + GD V I L+ F++ L+ + I+ ++ + L+ F KE +
Sbjct: 66 DFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLG 125
Query: 117 KFKETKKQFDKVREDLELSLVR---NAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVL 173
KE KK+FDK E SL+ N A + H ++EA + R+ F L+L+YV
Sbjct: 126 AVKEEKKKFDKETEK-NYSLIDKHLNLSAKKKDSH-LQEADIQVEQNRQHFYELSLEYVC 183
Query: 174 QINVLQAKKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEK 233
++ +Q +KKFE ++ MLSF +F+ QG+ L + Y +L + +
Sbjct: 184 KLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFEGTR 243
Query: 234 REMERKHAAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLF---KRASNAFKTWNRRW 290
E+E I+Q D S EGYL+ KR + +W + +
Sbjct: 244 SEVEELMNKIRQNPK-------------DHKRASQFTAEGYLYVQEKRPAPFGSSWVKHY 290
Query: 291 FSIQNSQLVYQK---------KLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLS---PT 338
+ + + KL D V L+ C+ + + I+RRFCF++ + P
Sbjct: 291 CMYRKAAKKFNMIPFEHRSGGKLGDG---EVFFLKECTKRHTDSIDRRFCFDIEAADRPG 347
Query: 339 KSCMLQADSEKLRQAWVQAVQASIASAYRES----PDSCYSERLDRTASPSTSSIDSATD 394
S +QA SE+ R+ W++A+ A ++ + P + +LD+ SA +
Sbjct: 348 VSLTMQAFSEEERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVE 407
Query: 395 TRERGVKGESVLQRVQSVAGNSQ 417
TR +G L RV V+ Q
Sbjct: 408 TRGINDQG---LYRVVGVSSKVQ 427
>gi|6912242 adaptor protein, phosphotyrosine interaction, PH domain
and leucine zipper containing 1 [Homo sapiens]
Length = 709
Score = 110 bits (275), Expect = 5e-24
Identities = 104/450 (23%), Positives = 203/450 (45%), Gaps = 30/450 (6%)
Query: 6 EECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDLS 65
EE ++DSP+ R+ + E D I +++L + + +A + + L +++
Sbjct: 10 EETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLTSKLLKEYE 69
Query: 66 QQC----QGDTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKET 121
+Q D V+S LQ+F+ + E+ + H +L Q ++ + F + D+++
Sbjct: 70 KQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKERDLKEILTL 129
Query: 122 KKQFDKVREDLELSLVRNAQAPRHRPHEVE--EATGALTLTRKCFRHLALDYVLQINVLQ 179
K+ F D + ++ R ++ + R ++ E T + +RK + Y +N LQ
Sbjct: 130 KEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQ 189
Query: 180 AKKKFEILDSMLSFMHAQSSFFQQG-YSLLHQLDPYMKKLAAELDQL--VIDSAVEKREM 236
KKK +L+ +L +M AQ SFF+ G +L QL+ ++ + + + +DS +E +
Sbjct: 190 YKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREMDSDIETMQQ 249
Query: 237 ERKHAAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAF--KTWNRRWFSIQ 294
+ + L + D +F V+ + GYL R TW+R+++ Q
Sbjct: 250 TIEDLEVASDPL---YVPDPDPTKFPVNR-NLTRKAGYLNARNKTGLVSSTWDRQFYFTQ 305
Query: 295 NSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLS--PTKSCMLQADSEKLRQ 352
L+ Q + D + D+ CSV + +RR+CF++ S KS +LQA+S+K +
Sbjct: 306 GGNLMSQAR-GDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHE 364
Query: 353 AWVQAVQASIASAY-RESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVL----Q 407
W+ + Y E+P+ + A + S++++ T + + ES+ Q
Sbjct: 365 EWICTINNISKQIYLSENPE-------ETAARVNQSALEAVTPSPSFQQRHESLRPAAGQ 417
Query: 408 RVQSVAGNSQCGDCGQPDPRWASINLGVLL 437
A S G G A+++L L+
Sbjct: 418 SRPPTARTSSSGSLGSESTNLAALSLDSLV 447
>gi|4505507 oligophrenin 1 [Homo sapiens]
Length = 802
Score = 107 bits (267), Expect = 5e-23
Identities = 98/385 (25%), Positives = 169/385 (43%), Gaps = 56/385 (14%)
Query: 3 VEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVR 62
+EF +C DSP FR + E + L++ K +++ G A +S R + S V+
Sbjct: 6 LEFSDCYLDSPDFRERLKCYEQE-------LERTNKFIKDVIKDGNALISAMRNYSSAVQ 58
Query: 63 DLSQQCQ-------GDTV------ISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQS 109
SQ Q GDT+ I+E + FA+ L EV N M++ A + + L++
Sbjct: 59 KFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLEN 118
Query: 110 FVKEDVRKFKETKKQFDKVREDLELSLVRNAQ-APRHRPHEVEEATGALTLTRKCFRHLA 168
F KE + KE KK+F+K E L R+ + + + +++EA + R F +
Sbjct: 119 FRKEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESS 178
Query: 169 LDYVLQINVLQAKKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVID 228
LDYV QI +Q KKF I++ +L+F+H+ L PY ++L L
Sbjct: 179 LDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNH 238
Query: 229 SAVEKREMERKHAAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFK-TWN 287
+ + EME +++ P +EGYL+ + A +W
Sbjct: 239 FSSTREEMEELKKRMKE-------------APQTCKLPGQPTIEGYLYTQEKWALGISWV 285
Query: 288 RRWFSIQNSQLVYQKKLKDALTVVVDD------------LRLCSVKPCEDIERRFCFEVL 335
+ + Y+K+ K ++ L+ C + E I++RFCF++
Sbjct: 286 KYYCQ-------YEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIE 338
Query: 336 SPTK--SCMLQADSEKLRQAWVQAV 358
+ + + LQA SE R+ W++A+
Sbjct: 339 TNERPGTITLQALSEANRRLWMEAM 363
>gi|24586663 adaptor protein, phosphotyrosine interaction, PH domain
and leucine zipper containing 2 [Homo sapiens]
Length = 664
Score = 104 bits (259), Expect = 4e-22
Identities = 96/417 (23%), Positives = 188/417 (45%), Gaps = 26/417 (6%)
Query: 6 EECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGK----AYVSTSRLFVSGV 61
EE ++DSP+ R+ + E D + ++L++ + A A S+ ++
Sbjct: 10 EEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYE 69
Query: 62 RDLSQQCQGDTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKET 121
+ +GD + L F+ + E+ H L Q ++ + F ++D+ +
Sbjct: 70 KQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTL 129
Query: 122 KKQFDKVREDLELSLVRNAQAPRHRPHE-VEEATGALTLTRKCFRHLA-LDYVLQINVLQ 179
K F + +LS+ + ++ P+ + +E V+ G + +HL+ L Y +N LQ
Sbjct: 130 KDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQYYCALNALQ 189
Query: 180 AKKKFEILDSMLSFMHAQSSFFQQGYSLL-HQLDPYMKKLAAELDQLVIDSAVEKREMER 238
+K+ +++ M+ F H Q +FF++G + ++D ++ +A + + ++ E +M
Sbjct: 190 YRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMR- 248
Query: 239 KHAAIQQRTLLQDFSYDES--KVEFDVDAP----SGVVMEGYLFKRASNAF--KTWNRRW 290
+ Q+ LL S DES + DV AP + + GYL R TW R +
Sbjct: 249 ----VSQQELL---SVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGLVTTTWERLY 301
Query: 291 FSIQNSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPT--KSCMLQADSE 348
F Q L+ Q + A ++ DL CSV + +RR+CF++ +P +LQA+S
Sbjct: 302 FFTQGGNLMCQPRGAVA-GGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESR 360
Query: 349 KLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESV 405
K + W+ A+ Y + +L++TA + + I S +E +++
Sbjct: 361 KENEEWICAINNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCPSQNL 417
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform a [Homo sapiens]
Length = 1205
Score = 103 bits (258), Expect = 5e-22
Identities = 71/242 (29%), Positives = 117/242 (48%), Gaps = 45/242 (18%)
Query: 287 NRRWFSIQNSQLVYQKKLKD---ALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCML 343
N+ + ++ ++ K L++ + + D+ + +VK +++RR F++ +P +
Sbjct: 209 NKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVK---EVDRR-SFDLTTPYRIFSF 264
Query: 344 QADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGE 403
ADSE ++ W++A+Q +IA A S
Sbjct: 265 SADSELEKEQWLEAMQGAIAEALSTS---------------------------------- 290
Query: 404 SVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDS- 462
V +R+ + A N C DCG P P WASINL V++C C+G HR LG SKVRSL +D
Sbjct: 291 EVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRK 350
Query: 463 -WEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKA 521
W L++L +LGN A N+ + A + + +P SSS + ++ KY E K+ R
Sbjct: 351 VWTETLIELFLQLGNGAGNRFWAANVPPSEALQP--SSSPSTRRCHLEAKYREGKYRRYH 408
Query: 522 PM 523
P+
Sbjct: 409 PL 410
Score = 35.8 bits (81), Expect = 0.17
Identities = 34/135 (25%), Positives = 57/135 (42%), Gaps = 17/135 (12%)
Query: 263 VDAPSG-------VVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDALTVVVDDL 315
+D P G V+ G+L K + +RW + L Y KDA + +
Sbjct: 70 MDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISV 129
Query: 316 RLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQASIA-SAYRESPDSCY 374
S ++ FEV++ ++ +A+S+ R+ W+QA+Q ++A R S Y
Sbjct: 130 ACISHVAAIGDQK---FEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAY 186
Query: 375 ------SERLDRTAS 383
SE+ DR S
Sbjct: 187 LLGVPGSEQPDRAGS 201
Score = 33.5 bits (75), Expect = 0.84
Identities = 34/107 (31%), Positives = 45/107 (42%), Gaps = 4/107 (3%)
Query: 665 ELHPGLLAHRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQ 724
EL L A A DL A L GA +N + E TPL A G + EFL
Sbjct: 416 ELDKALCA--AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRN 473
Query: 725 N-GADVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQR 770
N +V + DS H++ +L T FL + A L Q++R
Sbjct: 474 NRTTEVPRLDSMKPLEKHYSVVL-PTVSHSGFLYKTASAGKLLQDRR 519
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform c [Homo sapiens]
Length = 1450
Score = 103 bits (258), Expect = 5e-22
Identities = 71/242 (29%), Positives = 117/242 (48%), Gaps = 45/242 (18%)
Query: 287 NRRWFSIQNSQLVYQKKLKD---ALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCML 343
N+ + ++ ++ K L++ + + D+ + +VK +++RR F++ +P +
Sbjct: 454 NKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVK---EVDRR-SFDLTTPYRIFSF 509
Query: 344 QADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGE 403
ADSE ++ W++A+Q +IA A S
Sbjct: 510 SADSELEKEQWLEAMQGAIAEALSTS---------------------------------- 535
Query: 404 SVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDS- 462
V +R+ + A N C DCG P P WASINL V++C C+G HR LG SKVRSL +D
Sbjct: 536 EVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRK 595
Query: 463 -WEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKA 521
W L++L +LGN A N+ + A + + +P SSS + ++ KY E K+ R
Sbjct: 596 VWTETLIELFLQLGNGAGNRFWAANVPPSEALQP--SSSPSTRRCHLEAKYREGKYRRYH 653
Query: 522 PM 523
P+
Sbjct: 654 PL 655
Score = 35.8 bits (81), Expect = 0.17
Identities = 34/135 (25%), Positives = 57/135 (42%), Gaps = 17/135 (12%)
Query: 263 VDAPSG-------VVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDALTVVVDDL 315
+D P G V+ G+L K + +RW + L Y KDA + +
Sbjct: 315 MDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISV 374
Query: 316 RLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQASIA-SAYRESPDSCY 374
S ++ FEV++ ++ +A+S+ R+ W+QA+Q ++A R S Y
Sbjct: 375 ACISHVAAIGDQK---FEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAY 431
Query: 375 ------SERLDRTAS 383
SE+ DR S
Sbjct: 432 LLGVPGSEQPDRAGS 446
Score = 33.5 bits (75), Expect = 0.84
Identities = 34/107 (31%), Positives = 45/107 (42%), Gaps = 4/107 (3%)
Query: 665 ELHPGLLAHRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQ 724
EL L A A DL A L GA +N + E TPL A G + EFL
Sbjct: 661 ELDKALCA--AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRN 718
Query: 725 N-GADVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQR 770
N +V + DS H++ +L T FL + A L Q++R
Sbjct: 719 NRTTEVPRLDSMKPLEKHYSVVL-PTVSHSGFLYKTASAGKLLQDRR 764
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.131 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,381,608
Number of Sequences: 37866
Number of extensions: 1427244
Number of successful extensions: 8375
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 349
Number of HSP's successfully gapped in prelim test: 171
Number of HSP's that attempted gapping in prelim test: 6057
Number of HSP's gapped (non-prelim): 1935
length of query: 834
length of database: 18,247,518
effective HSP length: 111
effective length of query: 723
effective length of database: 14,044,392
effective search space: 10154095416
effective search space used: 10154095416
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.