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Search of human proteins with 21735483
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21735483 transient receptor potential cation channel,
subfamily V, member 3 [Homo sapiens]
(790 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21735483 transient receptor potential cation channel, subfami... 1583 0.0
gi|74315354 transient receptor potential cation channel, subfami... 543 e-154
gi|74315352 transient receptor potential cation channel, subfami... 543 e-154
gi|74315350 transient receptor potential cation channel, subfami... 543 e-154
gi|74315348 transient receptor potential cation channel, subfami... 543 e-154
gi|22547184 transient receptor potential cation channel, subfami... 540 e-153
gi|20127551 transient receptor potential cation channel, subfami... 433 e-121
gi|22547180 transient receptor potential cation channel, subfami... 299 8e-81
gi|21314682 transient receptor potential cation channel, subfami... 249 9e-66
gi|17505200 transient receptor potential cation channel, subfami... 236 6e-62
gi|116534990 ankyrin-like protein 1 [Homo sapiens] 70 1e-11
gi|209863032 transient receptor potential cation channel, subfam... 54 6e-07
gi|209863030 transient receptor potential cation channel, subfam... 54 6e-07
gi|209863026 transient receptor potential cation channel, subfam... 54 6e-07
gi|209863024 transient receptor potential cation channel, subfam... 54 6e-07
gi|7706747 transient receptor potential cation channel, subfamil... 54 6e-07
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 53 1e-06
gi|109689695 transient receptor potential cation channel, subfam... 52 3e-06
gi|11225266 transient receptor potential cation channel, subfami... 52 3e-06
gi|6912736 transient receptor potential cation channel, subfamil... 50 6e-06
gi|4507689 transient receptor potential cation channel, subfamil... 50 8e-06
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 50 1e-05
gi|209863028 transient receptor potential cation channel, subfam... 49 2e-05
gi|94538366 transient receptor potential cation channel, subfami... 49 2e-05
gi|9966865 transient receptor potential cation channel, subfamil... 48 4e-05
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 47 5e-05
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 47 5e-05
gi|21264330 mindbomb homolog 2 [Homo sapiens] 47 7e-05
gi|18921093 transient receptor potential cation channel, subfami... 47 9e-05
gi|5730102 transient receptor potential cation channel, subfamil... 47 9e-05
>gi|21735483 transient receptor potential cation channel, subfamily
V, member 3 [Homo sapiens]
Length = 790
Score = 1583 bits (4098), Expect = 0.0
Identities = 790/790 (100%), Positives = 790/790 (100%)
Query: 1 MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTS 60
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTS
Sbjct: 1 MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTS 60
Query: 61 PPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLK 120
PPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLK
Sbjct: 61 PPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLK 120
Query: 121 KRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNIN 180
KRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNIN
Sbjct: 121 KRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNIN 180
Query: 181 PNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGAD 240
PNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGAD
Sbjct: 181 PNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGAD 240
Query: 241 VNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNIL 300
VNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNIL
Sbjct: 241 VNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNIL 300
Query: 301 HALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYI 360
HALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYI
Sbjct: 301 HALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYI 360
Query: 361 LSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEML 420
LSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEML
Sbjct: 361 LSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEML 420
Query: 421 TLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMG 480
TLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMG
Sbjct: 421 TLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMG 480
Query: 481 WLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLY 540
WLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLY
Sbjct: 481 WLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLY 540
Query: 541 LFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLG 600
LFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLG
Sbjct: 541 LFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLG 600
Query: 601 FGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLIT 660
FGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLIT
Sbjct: 601 FGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLIT 660
Query: 661 YVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGEL 720
YVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGEL
Sbjct: 661 YVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGEL 720
Query: 721 CKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFE 780
CKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFE
Sbjct: 721 CKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFE 780
Query: 781 EVEEFPETSV 790
EVEEFPETSV
Sbjct: 781 EVEEFPETSV 790
>gi|74315354 transient receptor potential cation channel, subfamily
V, member 1 [Homo sapiens]
Length = 839
Score = 543 bits (1398), Expect = e-154
Identities = 295/663 (44%), Positives = 414/663 (62%), Gaps = 40/663 (6%)
Query: 120 KKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNI 179
++ IF AV++ ++L LL+ LQ+ + D + D +TGKTCL+KA+LN+
Sbjct: 115 RRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKD--------PETGKTCLLKAMLNL 166
Query: 180 NPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGA 239
+ + +LL A + D L +NA YT+ Y+GQTAL+IAIERR + LL+ GA
Sbjct: 167 HDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGA 226
Query: 240 DVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEH--EQTDITSRDSRGN 297
DV A A G FF GFYFGE PL+LAACTNQ IV+ L+++ + DI++RDS GN
Sbjct: 227 DVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGN 286
Query: 298 NILHALVTVAEDFKTQNDFVKRMYDMILLRSGNW----ELETTRNNDGLTPLQLAAKMGK 353
+LHALV VA++ FV MY+ IL+ +LE N G+TPL LAA GK
Sbjct: 287 TVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346
Query: 354 AEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTN- 412
+L YIL REI+E R LSRKFT+WAYGPV SSLYDL+ +DT NSVLE+ Y+++
Sbjct: 347 IGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSE 406
Query: 413 IDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHP 472
NRH+ML +EPL+ LL KW +F K +F+ +F Y Y I T+ +YYRP + +P P
Sbjct: 407 TPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRP--VDGLP-P 463
Query: 473 LALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVL 532
+ + ++ G + ++ + + GI FL R ++++ D++ +FF+Q++
Sbjct: 464 FKMEKTGDYFRVTGEILSVLGGVYFFFR-GIQYFLQRRPSMKTLFVDSYSEMLFFLQSLF 522
Query: 533 VILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLF 592
++ +V LY KEY+A +V ++ALGW NMLYYTRGFQ MG+Y+VMI+K+IL D+ +F+F
Sbjct: 523 MLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMF 582
Query: 593 VYIVFLLGFGVALASLIEKCPKDNKDC----------------SSYGSFSDAVLELFKLT 636
VYIVFL GF A+ +LIE D+ SSY S LELFK T
Sbjct: 583 VYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFT 642
Query: 637 IGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQR 696
IG+GDL +N + +F+ LL+ YVILT++LLLNMLIALMGETV +++ES+ IW+LQR
Sbjct: 643 IGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQR 702
Query: 697 ARTILEFEKMLPEWLRSRFRMGELCKV-----AEDDFRLCLRINEVKWTEWKTHVSFLNE 751
A TIL+ EK + +R FR G+L +V +DD+R C R++EV WT W T+V +NE
Sbjct: 703 AITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINE 762
Query: 752 DPG 754
DPG
Sbjct: 763 DPG 765
>gi|74315352 transient receptor potential cation channel, subfamily
V, member 1 [Homo sapiens]
Length = 839
Score = 543 bits (1398), Expect = e-154
Identities = 295/663 (44%), Positives = 414/663 (62%), Gaps = 40/663 (6%)
Query: 120 KKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNI 179
++ IF AV++ ++L LL+ LQ+ + D + D +TGKTCL+KA+LN+
Sbjct: 115 RRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKD--------PETGKTCLLKAMLNL 166
Query: 180 NPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGA 239
+ + +LL A + D L +NA YT+ Y+GQTAL+IAIERR + LL+ GA
Sbjct: 167 HDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGA 226
Query: 240 DVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEH--EQTDITSRDSRGN 297
DV A A G FF GFYFGE PL+LAACTNQ IV+ L+++ + DI++RDS GN
Sbjct: 227 DVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGN 286
Query: 298 NILHALVTVAEDFKTQNDFVKRMYDMILLRSGNW----ELETTRNNDGLTPLQLAAKMGK 353
+LHALV VA++ FV MY+ IL+ +LE N G+TPL LAA GK
Sbjct: 287 TVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346
Query: 354 AEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTN- 412
+L YIL REI+E R LSRKFT+WAYGPV SSLYDL+ +DT NSVLE+ Y+++
Sbjct: 347 IGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSE 406
Query: 413 IDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHP 472
NRH+ML +EPL+ LL KW +F K +F+ +F Y Y I T+ +YYRP + +P P
Sbjct: 407 TPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRP--VDGLP-P 463
Query: 473 LALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVL 532
+ + ++ G + ++ + + GI FL R ++++ D++ +FF+Q++
Sbjct: 464 FKMEKTGDYFRVTGEILSVLGGVYFFFR-GIQYFLQRRPSMKTLFVDSYSEMLFFLQSLF 522
Query: 533 VILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLF 592
++ +V LY KEY+A +V ++ALGW NMLYYTRGFQ MG+Y+VMI+K+IL D+ +F+F
Sbjct: 523 MLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMF 582
Query: 593 VYIVFLLGFGVALASLIEKCPKDNKDC----------------SSYGSFSDAVLELFKLT 636
VYIVFL GF A+ +LIE D+ SSY S LELFK T
Sbjct: 583 VYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFT 642
Query: 637 IGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQR 696
IG+GDL +N + +F+ LL+ YVILT++LLLNMLIALMGETV +++ES+ IW+LQR
Sbjct: 643 IGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQR 702
Query: 697 ARTILEFEKMLPEWLRSRFRMGELCKV-----AEDDFRLCLRINEVKWTEWKTHVSFLNE 751
A TIL+ EK + +R FR G+L +V +DD+R C R++EV WT W T+V +NE
Sbjct: 703 AITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINE 762
Query: 752 DPG 754
DPG
Sbjct: 763 DPG 765
>gi|74315350 transient receptor potential cation channel, subfamily
V, member 1 [Homo sapiens]
Length = 839
Score = 543 bits (1398), Expect = e-154
Identities = 295/663 (44%), Positives = 414/663 (62%), Gaps = 40/663 (6%)
Query: 120 KKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNI 179
++ IF AV++ ++L LL+ LQ+ + D + D +TGKTCL+KA+LN+
Sbjct: 115 RRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKD--------PETGKTCLLKAMLNL 166
Query: 180 NPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGA 239
+ + +LL A + D L +NA YT+ Y+GQTAL+IAIERR + LL+ GA
Sbjct: 167 HDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGA 226
Query: 240 DVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEH--EQTDITSRDSRGN 297
DV A A G FF GFYFGE PL+LAACTNQ IV+ L+++ + DI++RDS GN
Sbjct: 227 DVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGN 286
Query: 298 NILHALVTVAEDFKTQNDFVKRMYDMILLRSGNW----ELETTRNNDGLTPLQLAAKMGK 353
+LHALV VA++ FV MY+ IL+ +LE N G+TPL LAA GK
Sbjct: 287 TVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346
Query: 354 AEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTN- 412
+L YIL REI+E R LSRKFT+WAYGPV SSLYDL+ +DT NSVLE+ Y+++
Sbjct: 347 IGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSE 406
Query: 413 IDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHP 472
NRH+ML +EPL+ LL KW +F K +F+ +F Y Y I T+ +YYRP + +P P
Sbjct: 407 TPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRP--VDGLP-P 463
Query: 473 LALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVL 532
+ + ++ G + ++ + + GI FL R ++++ D++ +FF+Q++
Sbjct: 464 FKMEKTGDYFRVTGEILSVLGGVYFFFR-GIQYFLQRRPSMKTLFVDSYSEMLFFLQSLF 522
Query: 533 VILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLF 592
++ +V LY KEY+A +V ++ALGW NMLYYTRGFQ MG+Y+VMI+K+IL D+ +F+F
Sbjct: 523 MLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMF 582
Query: 593 VYIVFLLGFGVALASLIEKCPKDNKDC----------------SSYGSFSDAVLELFKLT 636
VYIVFL GF A+ +LIE D+ SSY S LELFK T
Sbjct: 583 VYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFT 642
Query: 637 IGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQR 696
IG+GDL +N + +F+ LL+ YVILT++LLLNMLIALMGETV +++ES+ IW+LQR
Sbjct: 643 IGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQR 702
Query: 697 ARTILEFEKMLPEWLRSRFRMGELCKV-----AEDDFRLCLRINEVKWTEWKTHVSFLNE 751
A TIL+ EK + +R FR G+L +V +DD+R C R++EV WT W T+V +NE
Sbjct: 703 AITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINE 762
Query: 752 DPG 754
DPG
Sbjct: 763 DPG 765
>gi|74315348 transient receptor potential cation channel, subfamily
V, member 1 [Homo sapiens]
Length = 839
Score = 543 bits (1398), Expect = e-154
Identities = 295/663 (44%), Positives = 414/663 (62%), Gaps = 40/663 (6%)
Query: 120 KKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNI 179
++ IF AV++ ++L LL+ LQ+ + D + D +TGKTCL+KA+LN+
Sbjct: 115 RRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKD--------PETGKTCLLKAMLNL 166
Query: 180 NPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGA 239
+ + +LL A + D L +NA YT+ Y+GQTAL+IAIERR + LL+ GA
Sbjct: 167 HDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGA 226
Query: 240 DVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEH--EQTDITSRDSRGN 297
DV A A G FF GFYFGE PL+LAACTNQ IV+ L+++ + DI++RDS GN
Sbjct: 227 DVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGN 286
Query: 298 NILHALVTVAEDFKTQNDFVKRMYDMILLRSGNW----ELETTRNNDGLTPLQLAAKMGK 353
+LHALV VA++ FV MY+ IL+ +LE N G+TPL LAA GK
Sbjct: 287 TVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346
Query: 354 AEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTN- 412
+L YIL REI+E R LSRKFT+WAYGPV SSLYDL+ +DT NSVLE+ Y+++
Sbjct: 347 IGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSE 406
Query: 413 IDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHP 472
NRH+ML +EPL+ LL KW +F K +F+ +F Y Y I T+ +YYRP + +P P
Sbjct: 407 TPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRP--VDGLP-P 463
Query: 473 LALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVL 532
+ + ++ G + ++ + + GI FL R ++++ D++ +FF+Q++
Sbjct: 464 FKMEKTGDYFRVTGEILSVLGGVYFFFR-GIQYFLQRRPSMKTLFVDSYSEMLFFLQSLF 522
Query: 533 VILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLF 592
++ +V LY KEY+A +V ++ALGW NMLYYTRGFQ MG+Y+VMI+K+IL D+ +F+F
Sbjct: 523 MLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMF 582
Query: 593 VYIVFLLGFGVALASLIEKCPKDNKDC----------------SSYGSFSDAVLELFKLT 636
VYIVFL GF A+ +LIE D+ SSY S LELFK T
Sbjct: 583 VYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFT 642
Query: 637 IGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQR 696
IG+GDL +N + +F+ LL+ YVILT++LLLNMLIALMGETV +++ES+ IW+LQR
Sbjct: 643 IGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQR 702
Query: 697 ARTILEFEKMLPEWLRSRFRMGELCKV-----AEDDFRLCLRINEVKWTEWKTHVSFLNE 751
A TIL+ EK + +R FR G+L +V +DD+R C R++EV WT W T+V +NE
Sbjct: 703 AITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINE 762
Query: 752 DPG 754
DPG
Sbjct: 763 DPG 765
>gi|22547184 transient receptor potential cation channel, subfamily
V, member 4 isoform a [Homo sapiens]
Length = 871
Score = 540 bits (1391), Expect = e-153
Identities = 297/658 (45%), Positives = 413/658 (62%), Gaps = 37/658 (5%)
Query: 123 IFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPN 182
+F VS G +L LL L +R DE+ + TGKTCL KALLN++
Sbjct: 154 LFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFRE--------PSTGKTCLPKALLNLSNG 205
Query: 183 TKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVN 242
+ + +LL AE + FIN+ + + Y GQTAL+IAIERR LL+A GADV+
Sbjct: 206 RNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVH 265
Query: 243 AHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLME--HEQTDITSRDSRGNNIL 300
A A+G FF PK + FYFGE PL+LAACTNQP IV L E H++ D+ +DSRGN +L
Sbjct: 266 AQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVL 325
Query: 301 HALVTVAEDFKTQNDFVKRMYDMILLRSGNW----ELETTRNNDGLTPLQLAAKMGKAEI 356
HALV +A++ + FV +MYD++LL+ LE NNDGL+PL +AAK GK I
Sbjct: 326 HALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGI 385
Query: 357 LKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDN-SVLEITVYNTNIDN 415
++I+ RE+ ++ R LSRKF DWAYGPV SSLYDL+++DT + SVLEI VYN+ I+N
Sbjct: 386 FQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEASVLEILVYNSKIEN 445
Query: 416 RHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLAL 475
RHEML +EP++ LL KW+KF F+++ Y + TL +YY+P E P+P
Sbjct: 446 RHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTP-PYPYRT 504
Query: 476 THKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVIL 535
T + +L+L G + L + +F+ + + S+ D F ++FI +VLVI+
Sbjct: 505 T--VDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIV 562
Query: 536 SVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYI 595
S LYL + YLA +V A+ LGW N LY+TRG + G YS+MIQK++ D+ +FL VY+
Sbjct: 563 SAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYL 622
Query: 596 VFLLGFGVALASLIEKCP------KDNKDCS--SYGS------FSDAVLELFKLTIGLGD 641
+F++G+ AL SL+ C +D +C+ +Y S FS +L+LFKLTIG+GD
Sbjct: 623 LFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGD 682
Query: 642 LNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTIL 701
L + ++KYP++F+ LL+TY+ILTFVLLLNMLIALMGETV VSKES+ IW+LQ A TIL
Sbjct: 683 LEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTIL 742
Query: 702 EFEKMLPEWLRSRFRMGELCKVAED-----DFRLCLRINEVKWTEWKTHVSFLNEDPG 754
+ E+ P +LR FR GE+ V + D R C R++EV W+ W ++ +NEDPG
Sbjct: 743 DIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPG 800
>gi|20127551 transient receptor potential cation channel, subfamily
V, member 2 [Homo sapiens]
Length = 764
Score = 433 bits (1113), Expect = e-121
Identities = 270/667 (40%), Positives = 376/667 (56%), Gaps = 50/667 (7%)
Query: 120 KKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNI 179
+ R+F AVS G E+L L L + + D + T TGKTCLMKA+LN+
Sbjct: 76 RDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEY--------TEGSTGKTCLMKAVLNL 127
Query: 180 NPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGA 239
+ LL ++ +NA+ T++ Y G +AL+IAIE+R LL+ GA
Sbjct: 128 KDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGA 187
Query: 240 DVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLME--HEQTDITSRDSRGN 297
+V+A A G FF K Q FYFGE PL+LAACT Q ++V L+E H+ + + DS+GN
Sbjct: 188 NVHARACGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGN 246
Query: 298 NILHALVTVAEDFKTQNDFVKRMYDMILLRSGNW----ELETTRNNDGLTPLQLAAKMGK 353
+LHALV ++++ V MYD +L +LE RN LTPL+LAAK GK
Sbjct: 247 TVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGK 306
Query: 354 AEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNI 413
EI ++IL RE L LSRKFT+W YGPV SLYDL +VD+ +NSVLEI ++
Sbjct: 307 IEIFRHILQREFSG--LSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHCKS 364
Query: 414 DNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPR-EEEAIPHP 472
+RH M+ LEPL+ LL KW FFL+F Y T V+Y++P +++A PH
Sbjct: 365 PHRHRMVVLEPLNKLLQAKWDLLIPK-FFLNFLCNLIYMFIFTAVAYHQPTLKKQAAPH- 422
Query: 473 LALTHKMGWLQLL-GRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAV 531
L ++G LL G + +L+ + + V + + F R + D++F +F QA+
Sbjct: 423 --LKAEVGNSMLLTGHILILLGGIYLLVGQ-LWYFWRRHVFIWISFIDSYFEILFLFQAL 479
Query: 532 LVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFL 591
L ++S L A + YL LV A+ LGW N+LYYTRGFQ G+YSVMIQKVIL D+L+FL
Sbjct: 480 LTVVSQVLCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFL 539
Query: 592 FVYIVFLLGFGVALASLIEKC--------------------PKDNKDCSSYGSFSDAVLE 631
+Y+VFL GF VAL SL ++ +D + + Y +A LE
Sbjct: 540 LIYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLE 599
Query: 632 LFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERI 691
LFK TIG+G+L Q+ + + L LL+ YV+LT++LLLNMLIALM ETV +V+ +S I
Sbjct: 600 LFKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSI 659
Query: 692 WRLQRARTILEFEKMLPEWLRSRFRMGELCKV-----AEDDFRLCLRINEVKWTEWKTHV 746
W+LQ+A ++LE E W R + R G + V D R C R+ EV W W+ +
Sbjct: 660 WKLQKAISVLEMENGY-WWCRKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTL 718
Query: 747 SFLNEDP 753
L EDP
Sbjct: 719 PTLCEDP 725
>gi|22547180 transient receptor potential cation channel, subfamily
V, member 4 isoform b [Homo sapiens]
Length = 811
Score = 299 bits (765), Expect = 8e-81
Identities = 174/459 (37%), Positives = 258/459 (56%), Gaps = 48/459 (10%)
Query: 341 GLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVS------------SS 388
G PL LAA + I+ Y+ K+ +R + + V+ +
Sbjct: 285 GELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTK 344
Query: 389 LYDL-----------TNVDTTTDN---SVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWK 434
+YDL +N++ +N S L + I NRHEML +EP++ LL KW+
Sbjct: 345 MYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGNRHEMLAVEPINELLRDKWR 404
Query: 435 KFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWA 494
KF F+++ Y + TL +YY+P E P+P T + +L+L G + L
Sbjct: 405 KFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTP-PYPYRTT--VDYLRLAGEVITLFTG 461
Query: 495 MCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLA 554
+ +F+ + + S+ D F ++FI +VLVI+S LYL + YLA +V A
Sbjct: 462 VLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFA 521
Query: 555 MALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCP- 613
+ LGW N LY+TRG + G YS+MIQK++ D+ +FL VY++F++G+ AL SL+ C
Sbjct: 522 LVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCAN 581
Query: 614 -----KDNKDCS--SYGS------FSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLIT 660
+D +C+ +Y S FS +L+LFKLTIG+GDL + ++KYP++F+ LL+T
Sbjct: 582 MKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVT 641
Query: 661 YVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGEL 720
Y+ILTFVLLLNMLIALMGETV VSKES+ IW+LQ A TIL+ E+ P +LR FR GE+
Sbjct: 642 YIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEM 701
Query: 721 CKVAED-----DFRLCLRINEVKWTEWKTHVSFLNEDPG 754
V + D R C R++EV W+ W ++ +NEDPG
Sbjct: 702 VTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPG 740
Score = 191 bits (486), Expect = 2e-48
Identities = 115/261 (44%), Positives = 154/261 (59%), Gaps = 14/261 (5%)
Query: 123 IFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPN 182
+F VS G +L LL L +R DE+ + TGKTCL KALLN++
Sbjct: 154 LFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFRE--------PSTGKTCLPKALLNLSNG 205
Query: 183 TKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVN 242
+ + +LL AE + FIN+ + + Y GQTAL+IAIERR LL+A GADV+
Sbjct: 206 RNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVH 265
Query: 243 AHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLME--HEQTDITSRDSRGNNIL 300
A A+G FF PK + FYFGE PL+LAACTNQP IV L E H++ D+ +DSRGN +L
Sbjct: 266 AQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVL 325
Query: 301 HALVTVAEDFKTQNDFVKRMYDMILLRSG----NWELETTRNNDGLTPLQLAAKMGKAEI 356
HALV +A++ + FV +MYD++LL+ + LE NNDGL+PL +AAK GK
Sbjct: 326 HALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGN 385
Query: 357 LKYILSREIKEKRLRSLSRKF 377
+L+ E + LR RKF
Sbjct: 386 RHEMLAVEPINELLRDKWRKF 406
>gi|21314682 transient receptor potential cation channel, subfamily
V, member 6 [Homo sapiens]
Length = 725
Score = 249 bits (635), Expect = 9e-66
Identities = 160/527 (30%), Positives = 270/527 (51%), Gaps = 43/527 (8%)
Query: 209 TEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLAL 268
T E YEGQTAL+IA+ + ++ L+A A V+A A G F + YFGE PL+
Sbjct: 111 TSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFR-RSPCNLIYFGEHPLSF 169
Query: 269 AACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRS 328
AAC N EIV+LL+EH DI ++DS GN +LH L+ + F +MY+++L
Sbjct: 170 AACVNSEEIVRLLIEHG-ADIRAQDSLGNTVLHILI-----LQPNKTFACQMYNLLLSYD 223
Query: 329 GNWE----LETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGP 384
+ + L+ N+ GLTP +LA G + ++++ + RK T W YGP
Sbjct: 224 RHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK-----------RKHTQWTYGP 272
Query: 385 VSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLS 444
++S+LYDLT +D++ D L + T ++L P+ L+ +KWK++ + F +
Sbjct: 273 LTSTLYDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRYGRPYFCML 332
Query: 445 FCFYFFYNITLTLVSYYRP-----------REEEAIPHPL---ALTHKMGWLQLLGRMFV 490
Y Y I T+ YRP R+ + L A ++L+G +
Sbjct: 333 GAIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEAYMTPKDDIRLVGELVT 392
Query: 491 LIWAMCISVKEGIAIFLLRPSDL--QSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYL 548
+I A+ I + E IF + + Q+IL FH + A +V++++ + L + +
Sbjct: 393 VIGAIIILLVEVPDIFRMGVTRFFGQTILGGP-FHVLIITYAFMVLVTMVMRLISASGEV 451
Query: 549 ACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASL 608
+ A+ LGW N++Y+ RGFQ +G +++MIQK+I D+++F ++ V +LGF A +
Sbjct: 452 VPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYII 511
Query: 609 IEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVL 668
+ +D ++ + + A+ F+L + + D N P ++ + I+ +L
Sbjct: 512 FQT--EDPEELGHFYDYPMALFSTFELFLTIIDGPANYNVDLPFMYSITYAAFAIIATLL 569
Query: 669 LLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPE--WLRS 713
+LN+LIA+MG+T V+ E + +WR Q T + E+ LP W RS
Sbjct: 570 MLNLLIAMMGDTHWRVAHERDELWRAQIVATTVMLERKLPRCLWPRS 616
Score = 30.8 bits (68), Expect = 5.1
Identities = 36/186 (19%), Positives = 77/186 (41%), Gaps = 18/186 (9%)
Query: 263 ETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYD 322
E+PL LAA N + + L+++E + R + G LH + + ++ + ++ +
Sbjct: 46 ESPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALH-IAALYDNLEAAMVLMEAAPE 104
Query: 323 MILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAY 382
++ +E T+ +G T L +A +++ +L+R S+S + T A+
Sbjct: 105 LV------FEPMTSELYEGQTALHIAVVNQNMNLVRALLARR------ASVSARATGTAF 152
Query: 383 GPVSSSL-----YDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFA 437
+L + L+ ++ + + + + L LH L+ K FA
Sbjct: 153 RRSPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212
Query: 438 KHMFFL 443
M+ L
Sbjct: 213 CQMYNL 218
>gi|17505200 transient receptor potential cation channel, subfamily
V, member 5 [Homo sapiens]
Length = 729
Score = 236 bits (602), Expect = 6e-62
Identities = 184/633 (29%), Positives = 307/633 (48%), Gaps = 75/633 (11%)
Query: 107 LAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASD 166
L K ++KR L+ + A E + L +LL++ R+R
Sbjct: 33 LDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQR---------------GA 77
Query: 167 TGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERR 226
G+T L A L N E +L+ A E + T EA+ GQTAL+IA+ +
Sbjct: 78 LGETALHIAALYDN---LEAALVLMEAAPE------LVFEPTTCEAFAGQTALHIAVVNQ 128
Query: 227 QGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQ 286
++ L+ A V+A A G F + YFGE PL+ AAC N EIV+LL+EH
Sbjct: 129 NVNLVRALLTRRASVSARATGTAFR-RSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHG- 186
Query: 287 TDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWE----LETTRNNDGL 342
DI ++DS GN +LH L+ + F +MY+++L G+ + L+ N+ GL
Sbjct: 187 ADIRAQDSLGNTVLHILI-----LQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGL 241
Query: 343 TPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDN- 401
TP +LA G + ++++ + R+ W YGP++S LYDLT +D+ +
Sbjct: 242 TPFKLAGVEGNTVMFQHLMQK-----------RRHIQWTYGPLTSILYDLTEIDSWGEEL 290
Query: 402 SVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYY 461
S LE+ V + + R ++L P+ L+ KW K+ + F + Y Y I T Y
Sbjct: 291 SFLELVVSSDKREAR-QILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVY 349
Query: 462 RP-----------REEEAIPHPL---ALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFL 507
RP R+ + L A + ++L+G + ++ A+ I + E IF
Sbjct: 350 RPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFR 409
Query: 508 LRPSDL--QSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYY 565
+ S ++IL FH + A LV++++ + L + + A+ LGW +++Y+
Sbjct: 410 VGASRYFGKTILGGP-FHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYF 468
Query: 566 TRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSF 625
TRGFQ +G +++MIQK+I D+++F ++ V +LGF A + + +D +S G F
Sbjct: 469 TRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQ-----TEDPTSLGQF 523
Query: 626 SD---AVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVE 682
D A+ F+L + + D + P +F + + I+ +L+LN+ IA+MG+T
Sbjct: 524 YDYPMALFTTFELFLTVIDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHW 583
Query: 683 NVSKESERIWRLQRARTILEFEKMLPE--WLRS 713
V++E + +WR Q T + E+ LP W RS
Sbjct: 584 RVAQERDELWRAQVVATTVMLERKLPRCLWPRS 616
>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
Length = 1119
Score = 69.7 bits (169), Expect = 1e-11
Identities = 77/338 (22%), Positives = 146/338 (43%), Gaps = 41/338 (12%)
Query: 397 TTTDNSVLE-ITVYNTNI-DNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNIT 454
T T + + E +T N + +NR E+L L MKW + ++ Y I
Sbjct: 673 TPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIP 732
Query: 455 LT-LVSYYRPRE--------EEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAI 505
+T LV +P E H L +L + V + ++ KE I
Sbjct: 733 MTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQI 792
Query: 506 FLLRPS---DLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANM 562
F + + D+ ++L ++ + ++ +L +F+ + A+ ++ C +A+ W N
Sbjct: 793 FQQKRNYFMDISNVLE-----WIIYTTGIIFVLPLFVEIPAHLQW-QCGAIAVYFYWMNF 846
Query: 563 LYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSY 622
L Y + F++ G++ VM++ VIL +L+ V+I LL FG++ L+ +
Sbjct: 847 LLYLQRFENCGIFIVMLE-VILKTLLRSTVVFIFLLLAFGLSFYILL----------NLQ 895
Query: 623 GSFSDAVLELFK-LTIGLGDLN---------IQQNSKYPILFLFLLITYVILTFVLLLNM 672
FS +L + + ++ LGD+N ++ +P+L L+++ I ++L+N+
Sbjct: 896 DPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNL 955
Query: 673 LIALMGETVENVSKESERIWRLQRARTILEFEKMLPEW 710
LI L + V K + + EK LP W
Sbjct: 956 LIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLPLW 993
Score = 40.8 bits (94), Expect = 0.005
Identities = 39/125 (31%), Positives = 52/125 (41%), Gaps = 24/125 (19%)
Query: 229 DIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEH-EQT 287
++A LI+ GAD+N K EG +PL LA + IV LL+ Q
Sbjct: 323 ELADYLISVGADIN----------KIDSEG----RSPLILATASASWNIVNLLLSKGAQV 368
Query: 288 DITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQL 347
DI +D+ G N LH V K +M + EL +NDG TPL
Sbjct: 369 DI--KDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIK-------ELVMDEDNDGCTPLHY 419
Query: 348 AAKMG 352
A + G
Sbjct: 420 ACRQG 424
Score = 37.0 bits (84), Expect = 0.071
Identities = 37/147 (25%), Positives = 58/147 (39%), Gaps = 26/147 (17%)
Query: 215 GQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQ 274
G T L+ A+E+ Q + L++ GA+ N FN PL +A
Sbjct: 98 GNTPLHCAVEKNQIESVKFLLSRGANPNLRN----FNMM----------APLHIAVQGMN 143
Query: 275 PEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELE 334
E++++L+EH D+ GN + T Q ILL+ G +
Sbjct: 144 NEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQ----------ILLKKGAKPCK 193
Query: 335 TTRNNDGLTPLQLAAKMGKAEILKYIL 361
+ N G P+ AA G E ++ IL
Sbjct: 194 S--NKWGCFPIHQAAFSGSKECMEIIL 218
Score = 31.6 bits (70), Expect = 3.0
Identities = 29/107 (27%), Positives = 47/107 (43%), Gaps = 13/107 (12%)
Query: 256 HEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQND 315
+EG G TPL LAA ++VQLL++ ++ D G LH +
Sbjct: 476 NEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLS--DHNGWTALH--------HASMGG 525
Query: 316 FVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILS 362
+ + M ++ N + + DG T L AA+ G A+ + +LS
Sbjct: 526 YTQTMK---VILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLS 569
>gi|209863032 transient receptor potential cation channel, subfamily
C, member 4 isoform zeta [Homo sapiens]
Length = 804
Score = 53.9 bits (128), Expect = 6e-07
Identities = 51/226 (22%), Positives = 99/226 (43%), Gaps = 40/226 (17%)
Query: 513 LQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLAC------------LVLAMALGWA 560
LQ + D W++ + F+ L + ++ L + A+ +Y A LV A
Sbjct: 253 LQDYIHD-WWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIA 311
Query: 561 NMLYYTR------GFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIE---- 610
N+ R +G + + +++L D+LKFLF+Y + LL F L L
Sbjct: 312 NIFSSLRLISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLYFYYEE 370
Query: 611 ---------KCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQ----QNSKYPILFLFL 657
+C K N +++ + + + LF GL +L + Q+ + +
Sbjct: 371 TKGLTCKGIRCEKQN---NAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 427
Query: 658 LITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEF 703
TY +++ V+LLNMLIA+M + + ++ ++ W+ R + + +
Sbjct: 428 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSY 473
>gi|209863030 transient receptor potential cation channel, subfamily
C, member 4 isoform delta [Homo sapiens]
Length = 836
Score = 53.9 bits (128), Expect = 6e-07
Identities = 51/226 (22%), Positives = 99/226 (43%), Gaps = 40/226 (17%)
Query: 513 LQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLAC------------LVLAMALGWA 560
LQ + D W++ + F+ L + ++ L + A+ +Y A LV A
Sbjct: 426 LQDYIHD-WWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIA 484
Query: 561 NMLYYTR------GFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIE---- 610
N+ R +G + + +++L D+LKFLF+Y + LL F L L
Sbjct: 485 NIFSSLRLISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLYFYYEE 543
Query: 611 ---------KCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQ----QNSKYPILFLFL 657
+C K N +++ + + + LF GL +L + Q+ + +
Sbjct: 544 TKGLTCKGIRCEKQN---NAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
Query: 658 LITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEF 703
TY +++ V+LLNMLIA+M + + ++ ++ W+ R + + +
Sbjct: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSY 646
>gi|209863026 transient receptor potential cation channel, subfamily
C, member 4 isoform beta [Homo sapiens]
Length = 893
Score = 53.9 bits (128), Expect = 6e-07
Identities = 51/226 (22%), Positives = 99/226 (43%), Gaps = 40/226 (17%)
Query: 513 LQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLAC------------LVLAMALGWA 560
LQ + D W++ + F+ L + ++ L + A+ +Y A LV A
Sbjct: 426 LQDYIHD-WWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIA 484
Query: 561 NMLYYTR------GFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIE---- 610
N+ R +G + + +++L D+LKFLF+Y + LL F L L
Sbjct: 485 NIFSSLRLISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLYFYYEE 543
Query: 611 ---------KCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQ----QNSKYPILFLFL 657
+C K N +++ + + + LF GL +L + Q+ + +
Sbjct: 544 TKGLTCKGIRCEKQN---NAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
Query: 658 LITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEF 703
TY +++ V+LLNMLIA+M + + ++ ++ W+ R + + +
Sbjct: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSY 646
>gi|209863024 transient receptor potential cation channel, subfamily
C, member 4 isoform epsilon [Homo sapiens]
Length = 982
Score = 53.9 bits (128), Expect = 6e-07
Identities = 51/226 (22%), Positives = 99/226 (43%), Gaps = 40/226 (17%)
Query: 513 LQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLAC------------LVLAMALGWA 560
LQ + D W++ + F+ L + ++ L + A+ +Y A LV A
Sbjct: 426 LQDYIHD-WWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIA 484
Query: 561 NMLYYTR------GFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIE---- 610
N+ R +G + + +++L D+LKFLF+Y + LL F L L
Sbjct: 485 NIFSSLRLISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLYFYYEE 543
Query: 611 ---------KCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQ----QNSKYPILFLFL 657
+C K N +++ + + + LF GL +L + Q+ + +
Sbjct: 544 TKGLTCKGIRCEKQN---NAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
Query: 658 LITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEF 703
TY +++ V+LLNMLIA+M + + ++ ++ W+ R + + +
Sbjct: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSY 646
>gi|7706747 transient receptor potential cation channel, subfamily
C, member 4 isoform alpha [Homo sapiens]
Length = 977
Score = 53.9 bits (128), Expect = 6e-07
Identities = 51/226 (22%), Positives = 99/226 (43%), Gaps = 40/226 (17%)
Query: 513 LQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLAC------------LVLAMALGWA 560
LQ + D W++ + F+ L + ++ L + A+ +Y A LV A
Sbjct: 426 LQDYIHD-WWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIA 484
Query: 561 NMLYYTR------GFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIE---- 610
N+ R +G + + +++L D+LKFLF+Y + LL F L L
Sbjct: 485 NIFSSLRLISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLYFYYEE 543
Query: 611 ---------KCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQ----QNSKYPILFLFL 657
+C K N +++ + + + LF GL +L + Q+ + +
Sbjct: 544 TKGLTCKGIRCEKQN---NAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
Query: 658 LITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEF 703
TY +++ V+LLNMLIA+M + + ++ ++ W+ R + + +
Sbjct: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSY 646
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 52.8 bits (125), Expect = 1e-06
Identities = 50/176 (28%), Positives = 80/176 (45%), Gaps = 31/176 (17%)
Query: 192 AFAEENDILGRFINAEYTE-----EAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAK 246
A+ + L INA+ +E + +EG AL++A + I +L+ AGAD NA
Sbjct: 51 AYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTL 110
Query: 247 GAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTV 306
TPL LA Q ++++LL++H S G N LH
Sbjct: 111 EE--------------TTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLH----- 151
Query: 307 AEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILS 362
F+ + +K +LLR G + +++ G+TPL +AA+ GK E L ++S
Sbjct: 152 QASFQENAEIIK-----LLLRKG--ANKECQDDFGITPLFVAAQYGKLESLSILIS 200
>gi|109689695 transient receptor potential cation channel, subfamily
M, member 8 [Homo sapiens]
Length = 1104
Score = 51.6 bits (122), Expect = 3e-06
Identities = 64/281 (22%), Positives = 125/281 (44%), Gaps = 46/281 (16%)
Query: 450 FYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLR 509
FY L L +Y + ++PHP L L +FVL C V++ +
Sbjct: 744 FYIAFLLLFAYVLLMDFHSVPHPPELV-------LYSLVFVLF---CDEVRQWYVNGVNY 793
Query: 510 PSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACL-VLAMALGWANMLYYTRG 568
+DL +++ D F F V + S + CL + L ++ +R
Sbjct: 794 FTDLWNVM-DTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSR- 851
Query: 569 FQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEK----------------- 611
++G +M+Q++++ DV FLF++ V+++ FGVA ++ +
Sbjct: 852 --NLGPKIIMLQRMLI-DVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPY 908
Query: 612 ------CPKDNKDCSSYGSFSDAVL---ELFKLTIGLGDLNIQQNSKYPILFLFLLITYV 662
P D D ++Y F+ E L + L + N+ + ++ + + L+ Y+
Sbjct: 909 LAMFGQVPSD-VDGTTY-DFAHCTFTGNESKPLCVELDEHNLPRFPEW--ITIPLVCIYM 964
Query: 663 ILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEF 703
+ T +LL+N+L+A+ G TV V + ++++W+ QR + E+
Sbjct: 965 LSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEY 1005
>gi|11225266 transient receptor potential cation channel, subfamily M,
member 5 [Homo sapiens]
Length = 1165
Score = 51.6 bits (122), Expect = 3e-06
Identities = 34/146 (23%), Positives = 71/146 (48%), Gaps = 19/146 (13%)
Query: 577 VMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNK------------DCSSYGS 624
+++ + ++ DV FLF V+L+ +GV +L+ P D + +G
Sbjct: 863 IIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLH--PHDGRLEWIFRRVLYRPYLQIFGQ 920
Query: 625 FSDAVLELFKLTIGLGDLNIQQNSKYPILF-----LFLLITYVILTFVLLLNMLIALMGE 679
++ ++ L ++ + P L+ + LL+T++++T VLL+N+LIA+
Sbjct: 921 IPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSY 980
Query: 680 TVENVSKESERIWRLQRARTILEFEK 705
T + V ++ W+ QR I+E+ +
Sbjct: 981 TFQVVQGNADMFWKFQRYNLIVEYHE 1006
>gi|6912736 transient receptor potential cation channel, subfamily
C, member 5 [Homo sapiens]
Length = 973
Score = 50.4 bits (119), Expect = 6e-06
Identities = 45/221 (20%), Positives = 95/221 (42%), Gaps = 42/221 (19%)
Query: 521 WFHFVFFIQAVLVILSVFLYLFAYKEYL------------------ACLVLAMALGWANM 562
W++ + F L + ++ L + AY +Y A ++ L +
Sbjct: 434 WWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRL 493
Query: 563 LYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIE------------ 610
+ +G + + +++L D+LKFLF+Y + LL F L L
Sbjct: 494 ISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNN 552
Query: 611 ----KCPKDNKDCSSYGSFSDAVLELFKLTIGLGDL---NIQQNSKYP-ILFLFLLITYV 662
+C K N +++ + + + LF GL +L N++ ++ + + TY
Sbjct: 553 CKGIRCEKQN---NAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYN 609
Query: 663 ILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEF 703
+++ V+LLNMLIA+M + + ++ ++ W+ R + + +
Sbjct: 610 VISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSY 650
>gi|4507689 transient receptor potential cation channel, subfamily M,
member 2 [Homo sapiens]
Length = 1503
Score = 50.1 bits (118), Expect = 8e-06
Identities = 42/152 (27%), Positives = 72/152 (47%), Gaps = 26/152 (17%)
Query: 577 VMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLT 636
++I K ++ DV FLF+ V+++ FGVA +++ + D G+ + L +F
Sbjct: 924 IIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNER-RVDWLFRGAVYHSYLTIFGQI 982
Query: 637 IGLGD-LNI-----------------------QQNSKYPI-LFLFLLITYVILTFVLLLN 671
G D +N QQ +P L + LL Y++ T +LLLN
Sbjct: 983 PGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFTNILLLN 1042
Query: 672 MLIALMGETVENVSKESERIWRLQRARTILEF 703
+LIA+ T + V + +++IW+ QR I E+
Sbjct: 1043 LLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEY 1074
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 49.7 bits (117), Expect = 1e-05
Identities = 44/152 (28%), Positives = 70/152 (46%), Gaps = 26/152 (17%)
Query: 211 EAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAA 270
+ +EG AL++A + I +L+ AGAD NA TPL LA
Sbjct: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEE--------------TTPLFLAV 47
Query: 271 CTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGN 330
Q ++++LL++H S G N LH F+ + +K +LLR G
Sbjct: 48 ENGQIDVLRLLLQHGANVNGSHSMCGWNSLH-----QASFQENAEIIK-----LLLRKG- 96
Query: 331 WELETTRNNDGLTPLQLAAKMGKAEILKYILS 362
+ +++ G+TPL +AA+ GK E L ++S
Sbjct: 97 -ANKECQDDFGITPLFVAAQYGKLESLSILIS 127
>gi|209863028 transient receptor potential cation channel, subfamily
C, member 4 isoform gamma [Homo sapiens]
Length = 828
Score = 48.9 bits (115), Expect = 2e-05
Identities = 49/211 (23%), Positives = 93/211 (44%), Gaps = 40/211 (18%)
Query: 513 LQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLAC------------LVLAMALGWA 560
LQ + D W++ + F+ L + ++ L + A+ +Y A LV A
Sbjct: 426 LQDYIHD-WWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIA 484
Query: 561 NMLYYTR------GFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIE---- 610
N+ R +G + + +++L D+LKFLF+Y + LL F L L
Sbjct: 485 NIFSSLRLISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLYFYYEE 543
Query: 611 ---------KCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQ----QNSKYPILFLFL 657
+C K N +++ + + + LF GL +L + Q+ + +
Sbjct: 544 TKGLTCKGIRCEKQN---NAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
Query: 658 LITYVILTFVLLLNMLIALMGETVENVSKES 688
TY +++ V+LLNMLIA+M + + +++ +
Sbjct: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIARRA 631
>gi|94538366 transient receptor potential cation channel, subfamily M,
member 1 [Homo sapiens]
Length = 1603
Score = 48.9 bits (115), Expect = 2e-05
Identities = 38/151 (25%), Positives = 74/151 (49%), Gaps = 20/151 (13%)
Query: 572 MGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSS---------- 621
+G Y +MI K+++ D+L F+ + +V L+ FGVA +++ K + +
Sbjct: 952 LGPYVMMIGKMMI-DMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMI 1010
Query: 622 YGSFSDAVLELFKLTIGLG---DLNIQQNSKYPI------LFLFLLITYVILTFVLLLNM 672
YG ++L+ + I +L ++ + P L L+ Y+++ +LL+N+
Sbjct: 1011 YGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNL 1070
Query: 673 LIALMGETVENVSKESERIWRLQRARTILEF 703
LIA+ T V S ++W+ QR + I+ F
Sbjct: 1071 LIAVFNNTFFEVKSISNQVWKFQRYQLIMTF 1101
>gi|9966865 transient receptor potential cation channel, subfamily
C, member 7 [Homo sapiens]
Length = 862
Score = 47.8 bits (112), Expect = 4e-05
Identities = 34/156 (21%), Positives = 76/156 (48%), Gaps = 8/156 (5%)
Query: 553 LAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKC 612
+A+ L ++ + Y +S G + + + + D+ KF+ ++I+ + F + + +L
Sbjct: 546 IAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVIFIMVFVAFMIGMFNLYSYY 604
Query: 613 PKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFL-----FLLITYVILTFV 667
+ K ++ + ++ LF GL ++ I KY F+ L Y + V
Sbjct: 605 -RGAKYNPAFTTVEESFKTLFWSIFGLSEV-ISVVLKYDHKFIENIGYVLYGVYNVTMVV 662
Query: 668 LLLNMLIALMGETVENVSKESERIWRLQRARTILEF 703
+LLNMLIA++ + + + ++++ W+ RA+ L +
Sbjct: 663 VLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSY 698
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 47.4 bits (111), Expect = 5e-05
Identities = 48/186 (25%), Positives = 79/186 (42%), Gaps = 38/186 (20%)
Query: 197 NDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFF------ 250
+++L R N + + +G TAL+IA Q ++ +L+ GA+VNA ++ F
Sbjct: 91 SELLQREANVDAATK--KGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA 148
Query: 251 -------------NPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGN 297
N Q G TPLA+A ++V LL+E+ D++G
Sbjct: 149 QENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN--------DTKGK 200
Query: 298 NILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEIL 357
L AL A T + ++L N ++E + G TPL +AA G +
Sbjct: 201 VRLPALHIAARKDDT------KAAALLLQNDNNADVE---SKSGFTPLHIAAHYGNINVA 251
Query: 358 KYILSR 363
+L+R
Sbjct: 252 TLLLNR 257
Score = 43.5 bits (101), Expect = 8e-04
Identities = 78/331 (23%), Positives = 119/331 (35%), Gaps = 66/331 (19%)
Query: 145 LCRRRHDEDVPDFLM-HKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGR- 202
L R EDV FL+ H + S T K + E+ +LL + D G+
Sbjct: 538 LSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKS 597
Query: 203 -----FINAEYTEE----------------AYEGQTALNIAIERRQGDIAALLIAAGADV 241
+ A Y + A G T L+IA ++ Q DIA L+ GAD
Sbjct: 598 GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA 657
Query: 242 NAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILH 301
NA + G + LAA ++V LL+ ++ + G LH
Sbjct: 658 NAVTRQ--------------GIASVHLAAQEGHVDMVSLLL-GRNANVNLSNKSGLTPLH 702
Query: 302 AL-----VTVAEDFKTQNDFVKRMYDM------ILLRSGNWEL----------ETTRNND 340
V VAE Q V M + GN ++ + +
Sbjct: 703 LAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKN 762
Query: 341 GLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTD 400
G TPL AA+ G I+ +L L + A G ++ L ++ VDT
Sbjct: 763 GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNG----NTALG-IARRLGYISVVDTL-- 815
Query: 401 NSVLEITVYNTNIDNRHEMLTLEPLHTLLHM 431
V E T+ T + +H+M E ++ +L M
Sbjct: 816 KIVTEETMTTTTVTEKHKMNVPETMNEVLDM 846
Score = 41.6 bits (96), Expect = 0.003
Identities = 41/153 (26%), Positives = 71/153 (46%), Gaps = 27/153 (17%)
Query: 211 EAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAA 270
+A G T L+IA ++ + + LL+ GA + A + G TP+ +AA
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTES--------------GLTPIHVAA 441
Query: 271 CTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGN 330
IV LM H + T+ + RG LH Q + V+ L++ G
Sbjct: 442 FMGHVNIVSQLMHHGASPNTT-NVRGETALHMAARSG-----QAEVVR-----YLVQDGA 490
Query: 331 WELETTRNNDGLTPLQLAAKMGKAEILKYILSR 363
++E +D TPL ++A++GKA+I++ +L +
Sbjct: 491 -QVEAKAKDDQ-TPLHISARLGKADIVQQLLQQ 521
Score = 35.8 bits (81), Expect = 0.16
Identities = 37/145 (25%), Positives = 65/145 (44%), Gaps = 27/145 (18%)
Query: 217 TALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPE 276
TAL++A +A +L+ A+ NA A F TPL +A N+ +
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGF--------------TPLHIACKKNRIK 414
Query: 277 IVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETT 336
+++LL++H + I + G +H F + V + L+ G T
Sbjct: 415 VMELLLKHGAS-IQAVTESGLTPIHVAA-----FMGHVNIVSQ-----LMHHG--ASPNT 461
Query: 337 RNNDGLTPLQLAAKMGKAEILKYIL 361
N G T L +AA+ G+AE+++Y++
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLV 486
Score = 33.1 bits (74), Expect = 1.0
Identities = 34/158 (21%), Positives = 61/158 (38%), Gaps = 27/158 (17%)
Query: 206 AEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETP 265
A+ +A + QT L+I+ + DI L+ GA NA G TP
Sbjct: 490 AQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS--------------GYTP 535
Query: 266 LALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMIL 325
L L+A ++ L++H ++ +G LH + + +++L
Sbjct: 536 LHLSAREGHEDVAAFLLDH-GASLSITTKKGFTPLHVAAKYGK---------LEVANLLL 585
Query: 326 LRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSR 363
+S + GLTPL +AA ++ +L +
Sbjct: 586 QKSAS---PDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 47.4 bits (111), Expect = 5e-05
Identities = 44/151 (29%), Positives = 66/151 (43%), Gaps = 32/151 (21%)
Query: 215 GQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQ 274
G T L++A Q + LL++ GA VNA Y G TPL L AC
Sbjct: 463 GHTPLHVAAVCGQASLIDLLVSKGAMVNATD--------------YHGATPLHL-ACQKG 507
Query: 275 PEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELE 334
+ V LL+ H + +D+ GN LH T + D VK + +++E
Sbjct: 508 YQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHE-----DCVKALV--------YYDVE 554
Query: 335 TTR----NNDGLTPLQLAAKMGKAEILKYIL 361
+ R N G TPL +AA+ G +++ +L
Sbjct: 555 SCRLDIGNEKGDTPLHIAARWGYQGVIETLL 585
Score = 38.9 bits (89), Expect = 0.019
Identities = 55/243 (22%), Positives = 102/243 (41%), Gaps = 44/243 (18%)
Query: 83 MDSPQSPQDDVTETPSNPN-SPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVE 141
+ SPQ D +++ S + S + +++E+ +K R +++ AV++G +E +V L+E
Sbjct: 632 VQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLE-MVRYLLE 690
Query: 142 LQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILG 201
E ED+ D ++A+D + P K + ++ + G
Sbjct: 691 WTE-------EDLED-AEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS--------G 734
Query: 202 RFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAH------------AKGAF 249
+N + +G + L++A + D+ LL+ GA+ A +G F
Sbjct: 735 LGVNVT----SQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHF 790
Query: 250 --------FNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILH 301
N K + G TPL A E+V LL++H I + +++GN LH
Sbjct: 791 QVVKCLLDSNAKPNKKDLS-GNTPLIYACSGGHHELVALLLQH-GASINASNNKGNTALH 848
Query: 302 ALV 304
V
Sbjct: 849 EAV 851
Score = 32.0 bits (71), Expect = 2.3
Identities = 26/110 (23%), Positives = 49/110 (44%), Gaps = 15/110 (13%)
Query: 262 GETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMY 321
G TPL +AA Q ++ LL+ + + + D G LH ++ Y
Sbjct: 463 GHTPLHVAAVCGQASLIDLLVS-KGAMVNATDYHGATPLHLAC-------------QKGY 508
Query: 322 DMILLRSGNWELET-TRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRL 370
+ L +++ ++N+G TPL LA G + +K ++ +++ RL
Sbjct: 509 QSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRL 558
>gi|21264330 mindbomb homolog 2 [Homo sapiens]
Length = 1013
Score = 47.0 bits (110), Expect = 7e-05
Identities = 77/303 (25%), Positives = 122/303 (40%), Gaps = 78/303 (25%)
Query: 134 ELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAF 193
EL+ LL++ R D+PD D G T L A L P E R+LL+
Sbjct: 537 ELIRLLLQA------RAGVDLPD---------DEGNTALHYAALGNQP---EATRVLLSA 578
Query: 194 AEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVN---AHAKGAFF 250
D IN+ + TAL++A++R ++ L G DVN AH+
Sbjct: 579 GCRADA----INSTQS-------TALHVAVQRGFLEVVRALCERGCDVNLPDAHS----- 622
Query: 251 NPKYQHEGFYFGETPL--ALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAE 308
+TPL A++A T IV++L E D+T+ +S+G +LH
Sbjct: 623 ------------DTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGH 670
Query: 309 DFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSRE---- 364
+ IL R+ +L + DG T L LAA E+ + IL RE
Sbjct: 671 ALAVRK---------ILARAR--QLVDAKKEDGFTALHLAALNNHREVAQ-ILIREGRCD 718
Query: 365 --IKEKRLRSLSRKFTDWAYGPVSSSLYDL---TNVDTTTDNSVLEITVYNTNIDNRHEM 419
++ ++L+S A+ + L D N + ++ L + + RH++
Sbjct: 719 VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVAL------QRHQL 772
Query: 420 LTL 422
L L
Sbjct: 773 LPL 775
>gi|18921093 transient receptor potential cation channel, subfamily M,
member 6 [Homo sapiens]
Length = 2022
Score = 46.6 bits (109), Expect = 9e-05
Identities = 36/143 (25%), Positives = 68/143 (47%), Gaps = 13/143 (9%)
Query: 570 QSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAV 629
Q G Y MI K+ + + + + + LL FGVA +++ K+ S+ D V
Sbjct: 961 QHAGPYVTMIAKMTAN-MFYIVIIMAIVLLSFGVARKAILSP-----KEPPSWSLARDIV 1014
Query: 630 LELFKLTIG---LGDLNI--QQNSKYPILFL--FLLITYVILTFVLLLNMLIALMGETVE 682
E + + G G++++ Q S P FL FL Y+ + +++++N+LIA
Sbjct: 1015 FEPYWMIYGEVYAGEIDVCSSQPSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYL 1074
Query: 683 NVSKESERIWRLQRARTILEFEK 705
++ S +W+ R R I+ + +
Sbjct: 1075 DMESISNNLWKYNRYRYIMTYHE 1097
>gi|5730102 transient receptor potential cation channel, subfamily
C, member 6 [Homo sapiens]
Length = 931
Score = 46.6 bits (109), Expect = 9e-05
Identities = 31/150 (20%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 553 LAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKC 612
+A+ L ++ + Y +S G + + + + D+ KF+ ++I+ + F + + +L
Sbjct: 601 IAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVIFIMVFVAFMIGMFNLYSYY 659
Query: 613 PKDNKDCSSYGSFSDAVLELFKLTIGLGDLN---IQQNSKYPILFLFLLI-TYVILTFVL 668
K ++ + ++ LF GL ++ I N K+ ++L Y + ++
Sbjct: 660 I-GAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIV 718
Query: 669 LLNMLIALMGETVENVSKESERIWRLQRAR 698
LLNMLIA++ + + + +++ W+ RA+
Sbjct: 719 LLNMLIAMINSSFQEIEDDADVEWKFARAK 748
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,087,514
Number of Sequences: 37866
Number of extensions: 1313993
Number of successful extensions: 6094
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 92
Number of HSP's successfully gapped in prelim test: 173
Number of HSP's that attempted gapping in prelim test: 5045
Number of HSP's gapped (non-prelim): 858
length of query: 790
length of database: 18,247,518
effective HSP length: 110
effective length of query: 680
effective length of database: 14,082,258
effective search space: 9575935440
effective search space used: 9575935440
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.