Guide to the Human Genome
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Search of human proteins with 217035133

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|217035133 hypothetical protein LOC55765 isoform 2 [Homo
sapiens]
         (578 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|217035133 hypothetical protein LOC55765 isoform 2 [Homo sapiens]  1177   0.0  
gi|217035131 hypothetical protein LOC55765 isoform 1 [Homo sapiens]  1177   0.0  
gi|116063562 FERM domain containing 4A [Homo sapiens]                 225   1e-58
gi|150010540 FERM domain containing 4B [Homo sapiens]                 139   5e-33
gi|15826862 coiled-coil domain containing 120 isoform 3 [Homo sa...    96   9e-20
gi|254039614 coiled-coil domain containing 120 isoform 4 [Homo s...    96   9e-20
gi|254039612 coiled-coil domain containing 120 isoform 2 [Homo s...    96   9e-20
gi|254039610 coiled-coil domain containing 120 isoform 1 [Homo s...    96   9e-20
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]         52   2e-06
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...    49   1e-05
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                    49   1e-05
gi|41350201 epsin 1 isoform c [Homo sapiens]                           47   4e-05
gi|117306167 proline-rich protein BstNI subfamily 3 precursor [H...    47   5e-05
gi|37537554 hypothetical protein FLJ37538 [Homo sapiens]               47   5e-05
gi|47132519 Ras association and pleckstrin homology domains 1 is...    47   6e-05
gi|93352554 GPR158-like 1 [Homo sapiens]                               46   8e-05
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s...    46   1e-04
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ...    46   1e-04
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ...    46   1e-04
gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo s...    46   1e-04
gi|162951884 R3H domain containing 2 [Homo sapiens]                    46   1e-04
gi|222418647 mucin 7, secreted precursor [Homo sapiens]                45   1e-04
gi|222418649 mucin 7, secreted precursor [Homo sapiens]                45   1e-04
gi|222418645 mucin 7, secreted precursor [Homo sapiens]                45   1e-04
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]           45   1e-04
gi|122937271 WAS protein homolog associated with actin, golgi me...    45   1e-04
gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]       45   1e-04
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]       45   1e-04
gi|56549694 enabled homolog isoform a [Homo sapiens]                   45   2e-04
gi|39930375 enabled homolog isoform b [Homo sapiens]                   45   2e-04

>gi|217035133 hypothetical protein LOC55765 isoform 2 [Homo sapiens]
          Length = 578

 Score = 1177 bits (3044), Expect = 0.0
 Identities = 578/578 (100%), Positives = 578/578 (100%)

Query: 1   MESKDEVSDTDSGIILQSGPDSPVSPMKELTHAVHKQQRALEARLEACLEELRRLCLREA 60
           MESKDEVSDTDSGIILQSGPDSPVSPMKELTHAVHKQQRALEARLEACLEELRRLCLREA
Sbjct: 1   MESKDEVSDTDSGIILQSGPDSPVSPMKELTHAVHKQQRALEARLEACLEELRRLCLREA 60

Query: 61  ELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWALHREDPLSSLERQLALQLQITEAAR 120
           ELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWALHREDPLSSLERQLALQLQITEAAR
Sbjct: 61  ELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWALHREDPLSSLERQLALQLQITEAAR 120

Query: 121 RLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDD 180
           RLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDD
Sbjct: 121 RLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDD 180

Query: 181 SSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWK 240
           SSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWK
Sbjct: 181 SSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWK 240

Query: 241 ETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGR 300
           ETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGR
Sbjct: 241 ETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGR 300

Query: 301 TSAPATPEIQGRRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPL 360
           TSAPATPEIQGRRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPL
Sbjct: 301 TSAPATPEIQGRRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPL 360

Query: 361 PHAACHSCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELVA 420
           PHAACHSCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELVA
Sbjct: 361 PHAACHSCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELVA 420

Query: 421 HHPKLLLPPGYFPAGRYVVVAESPLPPGEWELRRAAPGPAYEEEGTPLRYQRLVPSRSRI 480
           HHPKLLLPPGYFPAGRYVVVAESPLPPGEWELRRAAPGPAYEEEGTPLRYQRLVPSRSRI
Sbjct: 421 HHPKLLLPPGYFPAGRYVVVAESPLPPGEWELRRAAPGPAYEEEGTPLRYQRLVPSRSRI 480

Query: 481 VRTPSLKDSPAGRGLSKAAVSEELKWWHERARLRSTRPHSLDRQGAFRVRSLPLGREGFG 540
           VRTPSLKDSPAGRGLSKAAVSEELKWWHERARLRSTRPHSLDRQGAFRVRSLPLGREGFG
Sbjct: 481 VRTPSLKDSPAGRGLSKAAVSEELKWWHERARLRSTRPHSLDRQGAFRVRSLPLGREGFG 540

Query: 541 RALGPRAQVPTVCVLRRSPDGAPVQVFVPEKGEIISQV 578
           RALGPRAQVPTVCVLRRSPDGAPVQVFVPEKGEIISQV
Sbjct: 541 RALGPRAQVPTVCVLRRSPDGAPVQVFVPEKGEIISQV 578


>gi|217035131 hypothetical protein LOC55765 isoform 1 [Homo sapiens]
          Length = 663

 Score = 1177 bits (3044), Expect = 0.0
 Identities = 578/578 (100%), Positives = 578/578 (100%)

Query: 1   MESKDEVSDTDSGIILQSGPDSPVSPMKELTHAVHKQQRALEARLEACLEELRRLCLREA 60
           MESKDEVSDTDSGIILQSGPDSPVSPMKELTHAVHKQQRALEARLEACLEELRRLCLREA
Sbjct: 86  MESKDEVSDTDSGIILQSGPDSPVSPMKELTHAVHKQQRALEARLEACLEELRRLCLREA 145

Query: 61  ELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWALHREDPLSSLERQLALQLQITEAAR 120
           ELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWALHREDPLSSLERQLALQLQITEAAR
Sbjct: 146 ELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWALHREDPLSSLERQLALQLQITEAAR 205

Query: 121 RLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDD 180
           RLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDD
Sbjct: 206 RLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDD 265

Query: 181 SSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWK 240
           SSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWK
Sbjct: 266 SSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWK 325

Query: 241 ETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGR 300
           ETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGR
Sbjct: 326 ETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGR 385

Query: 301 TSAPATPEIQGRRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPL 360
           TSAPATPEIQGRRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPL
Sbjct: 386 TSAPATPEIQGRRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPL 445

Query: 361 PHAACHSCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELVA 420
           PHAACHSCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELVA
Sbjct: 446 PHAACHSCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELVA 505

Query: 421 HHPKLLLPPGYFPAGRYVVVAESPLPPGEWELRRAAPGPAYEEEGTPLRYQRLVPSRSRI 480
           HHPKLLLPPGYFPAGRYVVVAESPLPPGEWELRRAAPGPAYEEEGTPLRYQRLVPSRSRI
Sbjct: 506 HHPKLLLPPGYFPAGRYVVVAESPLPPGEWELRRAAPGPAYEEEGTPLRYQRLVPSRSRI 565

Query: 481 VRTPSLKDSPAGRGLSKAAVSEELKWWHERARLRSTRPHSLDRQGAFRVRSLPLGREGFG 540
           VRTPSLKDSPAGRGLSKAAVSEELKWWHERARLRSTRPHSLDRQGAFRVRSLPLGREGFG
Sbjct: 566 VRTPSLKDSPAGRGLSKAAVSEELKWWHERARLRSTRPHSLDRQGAFRVRSLPLGREGFG 625

Query: 541 RALGPRAQVPTVCVLRRSPDGAPVQVFVPEKGEIISQV 578
           RALGPRAQVPTVCVLRRSPDGAPVQVFVPEKGEIISQV
Sbjct: 626 RALGPRAQVPTVCVLRRSPDGAPVQVFVPEKGEIISQV 663


>gi|116063562 FERM domain containing 4A [Homo sapiens]
          Length = 1039

 Score =  225 bits (573), Expect = 1e-58
 Identities = 147/330 (44%), Positives = 195/330 (59%), Gaps = 22/330 (6%)

Query: 1   MESKDEVSDTDSGIILQSGP---DSPVSPMKELTHAVHKQQRALEARLEACLEELRRLCL 57
           M SK ++    SG +L SG    DS  S  K++  A+  +Q ALE  L   LEEL++LCL
Sbjct: 355 MGSKGKIISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCL 414

Query: 58  REAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWAL---HREDPLSSLERQLALQLQ 114
           REAELTG LP EYPL PGE+ P VRRRIG A+KLD+  +     E  L  LER+ A+Q Q
Sbjct: 415 REAELTGKLPVEYPLDPGEEPPIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQ 474

Query: 115 ITEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNS--EPPPAAALPLG 172
           ITEAARRL  + N+S++ ++QRK S L   KKLQE++  + E R  S  +P   A+L + 
Sbjct: 475 ITEAARRLASDPNVSKKLKKQRKTSYLNALKKLQEIENAINENRIKSGKKPTQRASLIID 534

Query: 173 RELSASDDSSLSDGLLLEEEESQV-----PKPPPES---PAPPS--RPLPPQTLEGLQPT 222
               AS+DSSLSD L+LE+E+SQV     P   P     P PPS  RP PPQ+LEGL+  
Sbjct: 535 DGNIASEDSSLSDALVLEDEDSQVTSTISPLHSPHKGLPPRPPSHNRPPPPQSLEGLRQM 594

Query: 223 GPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEP 282
                  +++P++   W E+SLD PYEK +K S   S SSS    P  G  A +      
Sbjct: 595 HYHRNDYDKSPIKPKMWSESSLDEPYEKVKKRSS-HSHSSSHKRFPSTGSCAEAGG--GS 651

Query: 283 ASYHVVPIRGVPGQWQGRTSAPATPEIQGR 312
            S    PIRG+P  W  ++S P+TP+++ R
Sbjct: 652 NSLQNSPIRGLP-HWNSQSSMPSTPDLRVR 680



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 24/50 (48%), Positives = 36/50 (72%), Gaps = 2/50 (4%)

Query: 472 RLVPSRSRIVRTPSL-KDSPAGRGLSKAAVSEELKWWHERARLRSTRPHS 520
           RL PSRS+I+RTPSL ++    +G  +AAVS+EL+ W++R+   S + HS
Sbjct: 895 RLTPSRSQILRTPSLGREGAHDKGAGRAAVSDELRQWYQRS-TASHKEHS 943


>gi|150010540 FERM domain containing 4B [Homo sapiens]
          Length = 1034

 Score =  139 bits (351), Expect = 5e-33
 Identities = 100/297 (33%), Positives = 156/297 (52%), Gaps = 28/297 (9%)

Query: 1   MESKDEVSDTDSGIILQSGP-DSPVSP--MKELTHAVHKQQRALEARLEACLEELRRLCL 57
           +E+K +     +G ++ SG  DS VS    +E    + K+++ L+ +L   +EEL+++CL
Sbjct: 394 LEAKSQFIMASNGSLISSGSQDSEVSEEQKREKILELKKKEKLLQEKLLKKVEELKKICL 453

Query: 58  REAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWAL-HREDP-LSSLERQLALQLQI 115
           REAELTG +P EYPL  GEK P+VRRR+G A+KLDD  L   EDP L  LE    +Q ++
Sbjct: 454 REAELTGKMPKEYPLNIGEKPPQVRRRVGTAFKLDDNLLPSEEDPALQELESNFLIQQKL 513

Query: 116 TEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERR-RNSEPPPAAALPLGRE 174
            EAA++L  E +L +  +++RK       KKLQE++  + E R R  + P   A  L  +
Sbjct: 514 VEAAKKLANEPDLCKTVKKKRKQDYTDAMKKLQEIENAINEYRIRCGKKPSQKATVLPED 573

Query: 175 LSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRP--LPPQTLEGLQPTGPEAGSPERA 232
           +  S+ SSLSD    ++       P   S + P  P  LPP++L                
Sbjct: 574 IIPSESSSLSDTTTYDDPSDAFTFPGQRSSSVPHSPRILPPKSL---------------- 617

Query: 233 PVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATT----PQDGPSASSLWLLEPASY 285
            ++   ++++S++  +   R+S E  S  SSP  T    PQ G S  +  +L   +Y
Sbjct: 618 GIERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQGGRSMPTTPVLTRNAY 674


>gi|15826862 coiled-coil domain containing 120 isoform 3 [Homo
           sapiens]
          Length = 630

 Score = 95.9 bits (237), Expect = 9e-20
 Identities = 84/269 (31%), Positives = 125/269 (46%), Gaps = 41/269 (15%)

Query: 37  QQRALEARLEACLEELRRLCLREAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKL----D 92
           +QR L+  L   L+ELR++CL+EAELTG LP E PL+PGE+   VRRR   A        
Sbjct: 38  RQRTLQEALSLKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPTARAYPPPHP 97

Query: 93  DWALH-----REDPLSSLERQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQEEKKL 147
           + A H      E  L +LER++++Q QI  AARRL L  +LS + RR+R+       ++L
Sbjct: 98  NQAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLSTEQRRRRRQVQADALRRL 157

Query: 148 QELQRCLVERRRNSEPPPAAALPLGRELSASDDSSLS---------------DGLLLEEE 192
            EL+  L + R     P    LPL + L  S  S ++               + ++L  E
Sbjct: 158 HELEEQLRDVRARLGLP---VLPLPQPLPLSTGSVITTQGVCLGMRLAQLSQEDVVLHSE 214

Query: 193 ESQVP--------KPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSL 244
            S +         + P    +   RP PP+  + L+      GSPER     +PWK    
Sbjct: 215 SSSLSESGASHDNEEPHGCFSLAERPSPPKAWDQLRAV--SGGSPER----RTPWKPPPS 268

Query: 245 DHPYEKPRKSSEPWSESSSPATTPQDGPS 273
           D   +   + +   S +S   + P+   S
Sbjct: 269 DLYGDLKSRRNSVASPTSPTRSLPRSASS 297


>gi|254039614 coiled-coil domain containing 120 isoform 4 [Homo
           sapiens]
          Length = 618

 Score = 95.9 bits (237), Expect = 9e-20
 Identities = 84/269 (31%), Positives = 125/269 (46%), Gaps = 41/269 (15%)

Query: 37  QQRALEARLEACLEELRRLCLREAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKL----D 92
           +QR L+  L   L+ELR++CL+EAELTG LP E PL+PGE+   VRRR   A        
Sbjct: 26  RQRTLQEALSLKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPTARAYPPPHP 85

Query: 93  DWALH-----REDPLSSLERQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQEEKKL 147
           + A H      E  L +LER++++Q QI  AARRL L  +LS + RR+R+       ++L
Sbjct: 86  NQAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLSTEQRRRRRQVQADALRRL 145

Query: 148 QELQRCLVERRRNSEPPPAAALPLGRELSASDDSSLS---------------DGLLLEEE 192
            EL+  L + R     P    LPL + L  S  S ++               + ++L  E
Sbjct: 146 HELEEQLRDVRARLGLP---VLPLPQPLPLSTGSVITTQGVCLGMRLAQLSQEDVVLHSE 202

Query: 193 ESQVP--------KPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSL 244
            S +         + P    +   RP PP+  + L+      GSPER     +PWK    
Sbjct: 203 SSSLSESGASHDNEEPHGCFSLAERPSPPKAWDQLRAV--SGGSPER----RTPWKPPPS 256

Query: 245 DHPYEKPRKSSEPWSESSSPATTPQDGPS 273
           D   +   + +   S +S   + P+   S
Sbjct: 257 DLYGDLKSRRNSVASPTSPTRSLPRSASS 285


>gi|254039612 coiled-coil domain containing 120 isoform 2 [Homo
           sapiens]
          Length = 649

 Score = 95.9 bits (237), Expect = 9e-20
 Identities = 84/269 (31%), Positives = 125/269 (46%), Gaps = 41/269 (15%)

Query: 37  QQRALEARLEACLEELRRLCLREAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKL----D 92
           +QR L+  L   L+ELR++CL+EAELTG LP E PL+PGE+   VRRR   A        
Sbjct: 26  RQRTLQEALSLKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPTARAYPPPHP 85

Query: 93  DWALH-----REDPLSSLERQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQEEKKL 147
           + A H      E  L +LER++++Q QI  AARRL L  +LS + RR+R+       ++L
Sbjct: 86  NQAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLSTEQRRRRRQVQADALRRL 145

Query: 148 QELQRCLVERRRNSEPPPAAALPLGRELSASDDSSLS---------------DGLLLEEE 192
            EL+  L + R     P    LPL + L  S  S ++               + ++L  E
Sbjct: 146 HELEEQLRDVRARLGLP---VLPLPQPLPLSTGSVITTQGVCLGMRLAQLSQEDVVLHSE 202

Query: 193 ESQVP--------KPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSL 244
            S +         + P    +   RP PP+  + L+      GSPER     +PWK    
Sbjct: 203 SSSLSESGASHDNEEPHGCFSLAERPSPPKAWDQLRAV--SGGSPER----RTPWKPPPS 256

Query: 245 DHPYEKPRKSSEPWSESSSPATTPQDGPS 273
           D   +   + +   S +S   + P+   S
Sbjct: 257 DLYGDLKSRRNSVASPTSPTRSLPRSASS 285


>gi|254039610 coiled-coil domain containing 120 isoform 1 [Homo
           sapiens]
          Length = 661

 Score = 95.9 bits (237), Expect = 9e-20
 Identities = 84/269 (31%), Positives = 125/269 (46%), Gaps = 41/269 (15%)

Query: 37  QQRALEARLEACLEELRRLCLREAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKL----D 92
           +QR L+  L   L+ELR++CL+EAELTG LP E PL+PGE+   VRRR   A        
Sbjct: 38  RQRTLQEALSLKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPTARAYPPPHP 97

Query: 93  DWALH-----REDPLSSLERQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQEEKKL 147
           + A H      E  L +LER++++Q QI  AARRL L  +LS + RR+R+       ++L
Sbjct: 98  NQAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLSTEQRRRRRQVQADALRRL 157

Query: 148 QELQRCLVERRRNSEPPPAAALPLGRELSASDDSSLS---------------DGLLLEEE 192
            EL+  L + R     P    LPL + L  S  S ++               + ++L  E
Sbjct: 158 HELEEQLRDVRARLGLP---VLPLPQPLPLSTGSVITTQGVCLGMRLAQLSQEDVVLHSE 214

Query: 193 ESQVP--------KPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSL 244
            S +         + P    +   RP PP+  + L+      GSPER     +PWK    
Sbjct: 215 SSSLSESGASHDNEEPHGCFSLAERPSPPKAWDQLRAV--SGGSPER----RTPWKPPPS 268

Query: 245 DHPYEKPRKSSEPWSESSSPATTPQDGPS 273
           D   +   + +   S +S   + P+   S
Sbjct: 269 DLYGDLKSRRNSVASPTSPTRSLPRSASS 297


>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
          Length = 1682

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 83/335 (24%), Positives = 110/335 (32%), Gaps = 78/335 (23%)

Query: 158 RRNSEPPPAAALPLGRELSASDDSSLSDGLL----LEEEESQVPK-----PPPESPAPPS 208
           +R +EPP    +P       S +  LS G         E++ +P      PPP  P PP 
Sbjct: 198 KRAAEPPVVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGLPPGLPLPPPPLPPPPPP 257

Query: 209 RPLPPQTLEGLQPTGP--------------EAGSPER---APVQNSPWKETSLDH--PYE 249
            P PP  L GL  + P              +A  PER   AP +    +  SL H  PY 
Sbjct: 258 PPPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRH-SLPHPYPYP 316

Query: 250 KPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATPEI 309
            P  ++ P      PA  P  GP                  R    +  G   A   P  
Sbjct: 317 APAYTAHPPGHRLVPAAPPGPGP------------------RPPGAESHGCLPATRPPGS 358

Query: 310 QGRRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHAACHSCS 369
             R  + Q  R+DS  +              P   T  VP   +  ++PP       S S
Sbjct: 359 DLRESRVQRSRMDSSVS--------------PAATTACVP---YAPSRPPGLPGTTTSSS 401

Query: 370 EDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELV---AHHPKLL 426
             S S+        +PG    D  +  P      H   G    +  +  +   A  P L 
Sbjct: 402 SSSSSNTGLRGVEPNPGIPGAD-HYQTPALEVSHHGRLGPSAHSSRKPFLGAPAATPHLS 460

Query: 427 LPPGYFPAGRYVVVAESPLPPGEWELRRAAPGPAY 461
           LPPG            SP PP    L R  P PA+
Sbjct: 461 LPPG----------PSSPPPPPCPRLLRPPPPPAW 485



 Score = 37.0 bits (84), Expect = 0.050
 Identities = 48/172 (27%), Positives = 60/172 (34%), Gaps = 36/172 (20%)

Query: 163 PPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPP--------------------E 202
           PPP A L      +A +D  + + L    E    P PPP                    +
Sbjct: 480 PPPPAWLKGPACRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQD 539

Query: 203 SPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSESS 262
           S  PP+ P P  T      +G  + SP   PV   P        PY    +S +P     
Sbjct: 540 SHTPPTPPTPT-TSSSNSNSGSHSSSPA-GPVSFPP-------PPYLA--RSIDPLPRPP 588

Query: 263 SPATTPQDGPSASSLWLLEPA---SYHVVPIRGV--PGQWQGRTSAPATPEI 309
           SPA  PQD P       L PA   S H         P   + R S P TPE+
Sbjct: 589 SPAQNPQDPPLVPLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEV 640



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 55/223 (24%), Positives = 83/223 (37%), Gaps = 37/223 (16%)

Query: 19   GPDSPVSPMKELTHAVHKQQRALEARLEACLEELRRLCLREAELTG---TLPAEYPLKPG 75
            GP +P  P   L+    + +  +       LEE+ R C    E  G   T PA+ P+   
Sbjct: 891  GPMTPTQPPPPLSLPPARSESEV-------LEEISRACETLVERVGRSATDPAD-PVDTA 942

Query: 76   EKAPKVRRRIGAAYKLDDWALHREDPLSSLERQLALQLQITEAARRLCLEENLSRQARRQ 135
            E A     R+    +  + A        S +R+     +     RR C ++++ R+ R  
Sbjct: 943  EPADSGTERLLPPAQAKEEAGGVAAVSGSCKRRQKEHQKEHRRHRRAC-KDSVGRRPREG 1001

Query: 136  RKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDDSSLSDGLLLEEEESQ 195
            R  +  +  K  ++ +R L      SE         GRE S  D    S           
Sbjct: 1002 RAKAKAKVPK--EKSRRVLGNLDLQSEEIQ------GREKSRPDLGGASKA--------- 1044

Query: 196  VPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSP 238
                PP +PAPPS P P       QPT P A  P +   + +P
Sbjct: 1045 ---KPPTAPAPPSAPAP-----SAQPTPPSASVPGKKAREEAP 1079



 Score = 33.1 bits (74), Expect = 0.72
 Identities = 82/365 (22%), Positives = 104/365 (28%), Gaps = 71/365 (19%)

Query: 190 EEEESQVPKPPP-ESPA----PPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSL 244
           +E+   +P P P  +PA    PP   L P    G  P  P A S    P    P  +   
Sbjct: 303 QEQRHSLPHPYPYPAPAYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPGSDLRE 362

Query: 245 DHPYEKPRKSSE---------PWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPG 295
                    SS          P++ S  P   P    S+SS          V P  G+PG
Sbjct: 363 SRVQRSRMDSSVSPAATTACVPYAPSRPPGL-PGTTTSSSSSSSSNTGLRGVEPNPGIPG 421

Query: 296 QWQGRTSAPATPEIQGRRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPA 355
               +T A       GR G S       F   P      + P    +      P  C   
Sbjct: 422 ADHYQTPALEVSH-HGRLGPSAHSSRKPFLGAPAATPHLSLPPGPSS----PPPPPCPRL 476

Query: 356 TKPPLPHA-----ACHSCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAW 410
            +PP P A     AC +  ED       I      G+  P     +P  PP  HR     
Sbjct: 477 LRPPPPPAWLKGPACRAAREDG-----EILEELFFGTEGPP----RPAPPPLPHREGFLG 527

Query: 411 VPAG----------------------SRELVAHHPKLLLPPGYFPAGRYVVVAESPLP-- 446
            PA                       S      H      P  FP   Y+  +  PLP  
Sbjct: 528 PPASRFSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRP 587

Query: 447 -------------PGEWELRRAAPGPAYEEEGTPLRYQRLVPSRSRIVRTPSLKDSPAGR 493
                        P    L  A P   ++      R       R    +TP +   P   
Sbjct: 588 PSPAQNPQDPPLVPLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPG 647

Query: 494 GLSKA 498
            LSKA
Sbjct: 648 PLSKA 652



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 63/305 (20%), Positives = 103/305 (33%), Gaps = 50/305 (16%)

Query: 124 LEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDDSSL 183
           L+E++ ++  +Q+  + +  +  L+E    L    ++  P   A       ++ +  ++ 
Sbjct: 702 LDESIRKEEEQQQHEAGVAPQPPLKEPFASL----QSPFPTDTAPTTTAPAVAVTTTTTT 757

Query: 184 SDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETS 243
           +      +EE + P PP   P PP    PP +    QP  P   SP             S
Sbjct: 758 TTTTTATQEEEKKP-PPALPPPPPLAKFPPPSQP--QPPPPPPPSP------------AS 802

Query: 244 LDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSA 303
           L        +  +     +  A + + GP  ++ +               PG   G T+ 
Sbjct: 803 LLKSLASVLEGQKYCYRGTGAAVSTRPGPLPTTQY--------------SPGPPSGATAL 848

Query: 304 PATPEIQGRRGQSQ----SLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPP 359
           P T      +G  Q    S    S   GP  R R A     P   T T P    P + PP
Sbjct: 849 PPTSAAPSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPP--PLSLPP 906

Query: 360 LP---------HAACHSCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAW 410
                        AC +  E  G   +  + P    ++ P  S  + L PP   +     
Sbjct: 907 ARSESEVLEEISRACETLVERVGRSATDPADPVD--TAEPADSGTERLLPPAQAKEEAGG 964

Query: 411 VPAGS 415
           V A S
Sbjct: 965 VAAVS 969


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 77/323 (23%), Positives = 123/323 (38%), Gaps = 53/323 (16%)

Query: 107  RQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPA 166
            RQ    L   + A +LC          ++ K  + + E++ ++LQR   ++++   P PA
Sbjct: 1384 RQFVAALADLQEAVKLC-------PTNQEVKRLLARVEEECKQLQRS--QQQKQQGPLPA 1434

Query: 167  AALPLGRELSASDDSS--LSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTL-------- 216
               PL    +  D  +  LSD    EE E +   P  ES +P  R  P  ++        
Sbjct: 1435 ---PLNDSENEEDTPTPGLSDHFHSEETEEEETSPQEESVSPTPRSQPSSSVPSSYIRNL 1491

Query: 217  -EGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSAS 275
             EGLQ  G       RA +  S      L  P  +P    +P  ++    T+   G   S
Sbjct: 1492 QEGLQSKGRPVSPQSRAGIGKS------LREPVAQPGLLLQPSKQAQIVKTSQHLGSGQS 1545

Query: 276  SLW---LLEPASYHVVPIRGVPGQWQGRTSAPATPEIQG---------------RRGQSQ 317
            ++    +    S    P   +PG+     +   T  ++G               R G SQ
Sbjct: 1546 AVRNGSMKVQISSQNPPPSPMPGRIAATPAGSRTQHLEGTGTFTTRAGCGHFGDRLGPSQ 1605

Query: 318  SLRVDSFRAGPEGR--GRSAFPRRRPTHYTVTV----PDSCFPATKPPLPHAACHSCSED 371
            ++R+     GP      ++    R  +H +V V    P+    AT   + H A  + S  
Sbjct: 1606 NVRLQCGENGPAHPLPSKTKTTERLLSHSSVAVDAAPPNQGGLATCSDVRHPASLTSSGS 1665

Query: 372  SGSDVSSISHPTSPGSSSPDISF 394
            SGS  SSI   +S  S +   SF
Sbjct: 1666 SGSPSSSIKMSSSTSSLTSSSSF 1688


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 58/232 (25%), Positives = 92/232 (39%), Gaps = 30/232 (12%)

Query: 10  TDSGIILQS-GPDSPVSPMK---------ELTHAVHKQQRALEARLEACLEELRRLCLRE 59
           TD+ ++     P  PV+P K         E T  + +++R    + E   +E R    R+
Sbjct: 569 TDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERD 628

Query: 60  AELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWALHREDPLSSLERQLALQLQITEAA 119
             +     A       E+  + RRR        +    RE   +  E Q  LQ Q  EA 
Sbjct: 629 KRMREEQLAREAEARAEREAEARRR--------EEQEAREKAQAEQEEQERLQKQKEEAE 680

Query: 120 RRLCLEENLSRQARRQRKHSMLQEEKKLQELQRC--LVERRRNSEPPPAAALPLGRELSA 177
            R    E   RQ   + KH   QE+++ +  +R   +++R R SE          +E +A
Sbjct: 681 ARS--REEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANA 738

Query: 178 SDDS--------SLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGLQP 221
           +  S        + S GL  E  + + P P     + PS+ LP   + GLQP
Sbjct: 739 NGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKELPASLVNGLQP 790



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 29/84 (34%), Positives = 37/84 (44%), Gaps = 14/84 (16%)

Query: 155 VERRRNSEPPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQ 214
           V R+  ++  P+AA P        +D S S      E+ES  P  P  SPAP   P PPQ
Sbjct: 508 VRRKEEAKESPSAAGP--------EDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQ 559

Query: 215 TLEGLQPTGPEAGSPERAPVQNSP 238
             +      P A +P  A V  SP
Sbjct: 560 KEQ------PPAETPTDAAVLTSP 577



 Score = 33.9 bits (76), Expect = 0.42
 Identities = 41/166 (24%), Positives = 66/166 (39%), Gaps = 22/166 (13%)

Query: 196 VPKPPPESP-----APPSRPLP-----PQTLEGLQPTGPEAGSPERAPVQNSPWKETSLD 245
           VP  PP++P     A  S+ LP     P    G +P  P+  SP        P       
Sbjct: 44  VPDTPPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGP 103

Query: 246 HPYEKPRKSSEPWSESSSPAT----TPQDGPSASSLWLL-----EPASYHVVPIRGVPGQ 296
                PR+SS+P S ++ PA+    T Q+   A     L     E  + ++   + V  +
Sbjct: 104 RDARPPRRSSQP-SPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLE 162

Query: 297 WQGRTSAPATPEIQGRRG--QSQSLRVDSFRAGPEGRGRSAFPRRR 340
            + +  A    ++Q RR   + Q L+ +  RA  E R R    + +
Sbjct: 163 KEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNK 208



 Score = 33.1 bits (74), Expect = 0.72
 Identities = 21/72 (29%), Positives = 29/72 (40%), Gaps = 2/72 (2%)

Query: 197 PKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSE 256
           P+  P  P PP   L P T     P    A S ++ P++  P   +    P   P +   
Sbjct: 29  PEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLE--PESPSGQVGPRPAPPQEES 86

Query: 257 PWSESSSPATTP 268
           P SE+ S   TP
Sbjct: 87  PSSEAKSRGPTP 98


>gi|41350201 epsin 1 isoform c [Homo sapiens]
          Length = 550

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 98/397 (24%), Positives = 130/397 (32%), Gaps = 79/397 (19%)

Query: 101 PLSSLERQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRN 160
           P SS E +L LQL +  +      EE + R+    R    ++E K               
Sbjct: 178 PQSSGEEELQLQLALAMSKEEADQEERI-RRGDDLRLQMAIEESK--------------- 221

Query: 161 SEPPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKP---PPESPAPPSRPLPPQTLE 217
                       RE    ++SSL D  L +   +  P P   P   PAP +  +P     
Sbjct: 222 ------------RETGGKEESSLMD--LADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPT 267

Query: 218 ----GLQPTGPEA---GSPERAPVQNSPWKETSLDHPYEKP-----------RKSSEPWS 259
               G  P  P A   G P   P    PW+  +   P   P             + +PW 
Sbjct: 268 SDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWG 327

Query: 260 ESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGRRGQSQSL 319
             SS    P  GPSAS  W   PA             W G   +PA P   G        
Sbjct: 328 --SSDGGVPVSGPSASDPWTPAPA---------FSDPWGG---SPAKPSTNGTTAGGFDT 373

Query: 320 RVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPL--PHAACHSCSEDSGS-DV 376
             D F      R R+A P    +   + +     PA  P          S +E  GS   
Sbjct: 374 EPDEF--SDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPP 431

Query: 377 SSISHPTSPGSSSPDISFLQP---LSPPKTHRHRGAWVPAGSRELVAHHPKLLLPPGYFP 433
           ++   PT P   +P+ SFL P   L    +   R    P G++   A +P   LP G   
Sbjct: 432 AATPTPTPPTRKTPE-SFLGPNAALVDLDSLVSRPGPTPPGAK---ASNP--FLPGGGPA 485

Query: 434 AGRYVVVAESPLPPGEWELRRAAPGPAYEEEGTPLRY 470
            G  V     P PP    L +    P     G P  Y
Sbjct: 486 TGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTY 522


>gi|117306167 proline-rich protein BstNI subfamily 3 precursor [Homo
           sapiens]
          Length = 309

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 75/297 (25%), Positives = 98/297 (32%), Gaps = 32/297 (10%)

Query: 166 AAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRP--LPPQTLEGLQPTG 223
           ++A  L  ++S  +  S+  G   E    Q    P  +P PP +P   PPQ     Q   
Sbjct: 14  SSAQSLNEDVSQEESPSVISGKP-EGRRPQGGNQPQRTPPPPGKPEGRPPQGGNQSQGPP 72

Query: 224 PEAGSPERAPVQNS-------PWKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASS 276
           P  G PE  P Q         P        P +   +S  P      P   P  G + S 
Sbjct: 73  PRPGKPEGPPPQGGNQSQGPPPRPGKPEGQPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQ 132

Query: 277 LWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGRRGQSQSLRVDSFRAGPE-----GR 331
                P      P +G   Q QG    P  PE    +G +QS         PE     G 
Sbjct: 133 GPPPRPGKPEGPPPQG-GNQSQGPPPRPGKPEGPPPQGGNQSQGPPPHPGKPEGPPPQGG 191

Query: 332 GRSAFPRRRPTHYTVTVPDSCFPAT-KPPLPHAACHSCSEDSGSDVSSISHPTSPGSSSP 390
            +S  P  RP       P     +   PP P       S+          HP  P    P
Sbjct: 192 NQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPSQGGNKPQGPPPHPGKPQGPPP 251

Query: 391 DISFLQPLSPPKTHRHRGAWVPAGSRELVAHHPKLLLPPGYFPAGRYVVVAESPLPP 447
                +P  PP   R +G   P G       +P+  LPP   PAG+     + P PP
Sbjct: 252 Q-EGNKPQRPPPPGRPQGPPPPGG-------NPQQPLPP---PAGK----PQGPPPP 293



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 19/55 (34%), Positives = 23/55 (41%), Gaps = 6/55 (10%)

Query: 190 EEEESQVPKPP--PESPAPPS----RPLPPQTLEGLQPTGPEAGSPERAPVQNSP 238
           E  + Q P PP  P+ P PP     +PLPP   +   P  P  G     P Q  P
Sbjct: 253 EGNKPQRPPPPGRPQGPPPPGGNPQQPLPPPAGKPQGPPPPPQGGRPHRPPQGQP 307


>gi|37537554 hypothetical protein FLJ37538 [Homo sapiens]
          Length = 841

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 81/329 (24%), Positives = 110/329 (33%), Gaps = 53/329 (16%)

Query: 176 SASDDSSLSDGLLLEEEESQVPKPPPES----PAPPSRPLPPQTLEGLQPTG---PEAGS 228
           + +D  S     + EE +  +P+   E     P P +   PPQ    L P     P +  
Sbjct: 248 AGADSDSEESEAIYEEMKYPLPEEAGEGRANGPPPLTATSPPQQPHALPPHAHRRPASAL 307

Query: 229 PERAPVQNSPWKETSLDHPYEKP-----RKSSEPWSESSSPATTPQDGPSASSLWLLEPA 283
           P R     +P K T  + P   P     R     + ++ S + TP DG S   +      
Sbjct: 308 PSRR--DGTPTKTTPCEIPPPFPNLLQHRPPLLAFPQAKSASRTPGDGVSRLPVLCHSKE 365

Query: 284 SYHVVPIRGVPGQWQGRTSAPATPEIQGRR--GQSQSLRVDSFRAGPEGRGRSAFPRRRP 341
                P   VP + +     P  P        G S   R  S    P+G G+    R  P
Sbjct: 366 PAGSTPAPQVPARERETPPPPPPPPAANLLLLGPSGRARSHSTPLPPQGSGQPRGERELP 425

Query: 342 THYTVTVPDSCFPATKPPLPHAACHSCSEDSG-------SDVSSISHPTSP-----GSSS 389
             +++  P +      PP P A      +D         S V   +H   P     G+  
Sbjct: 426 NSHSMICPKAAGAPAAPPAPAALLPGPPKDKAVSYTMVYSAVKVTTHSVLPAGPPLGAGE 485

Query: 390 P----DISFL--------QPLSPPKTHRHRGAWVPAGSRELVAHHPKLLLPPGYFPAGRY 437
           P    +IS L        +P  P KT  H GA    G+   V HH   L  P   P    
Sbjct: 486 PKTEKEISVLHGMLCTSSRPPVPGKTSPHGGA---MGAAAGVLHHRGCLASPHSLPD--- 539

Query: 438 VVVAESPLPPGEWELRRAAPG----PAYE 462
                 PL P  W     A G    PAYE
Sbjct: 540 --PTVGPLTP-LWTYPATAAGLKRPPAYE 565


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 75/288 (26%), Positives = 99/288 (34%), Gaps = 43/288 (14%)

Query: 194  SQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPER-APV--QNSPWKETSLDHPYEK 250
            +QV  P P  P P   PLPPQ       T P   S +  APV  Q +P   T    P +K
Sbjct: 756  TQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKK 815

Query: 251  P---RKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATP 307
                  S  P S  + P   P         +  +P    + P+  V  Q   +   P TP
Sbjct: 816  QPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTP 875

Query: 308  EIQGRRGQSQSLRVDSFRAGPEG-RGRSAFPRRRPTHYTVTVPD---------------- 350
                   +SQ L+       P+      A P+ +P+   V  PD                
Sbjct: 876  PAM----ESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPP 931

Query: 351  -SCFPATKPPLPHAACHSCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGA 409
             S  PA  PP P  A  +  + SGS     S  +SPG   P         PP   R+   
Sbjct: 932  PSPVPAPPPPPPPTASPT-PDKSGSPGKKTSKTSSPGGKKP---------PPTPQRNSSI 981

Query: 410  WVPAGSRELVAHHPKLLLPPGYFPAGRYVVVAESPLPPGEWELRRAAP 457
               +G     A HP+   P       ++   AES  P  E     AAP
Sbjct: 982  KSSSG-----AEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAP 1024



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 41/145 (28%), Positives = 60/145 (41%), Gaps = 34/145 (23%)

Query: 192  EESQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPER---------------APVQN 236
            E S V  PPP SP P   P PP T     PT  ++GSP +                P +N
Sbjct: 922  ESSLVFPPPPPSPVPAPPPPPPPT---ASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRN 978

Query: 237  SPWKETS-LDHPYEKPRKSS--------EPWSESSSPATTPQDGPSASSLWLLEPASYHV 287
            S  K +S  +HP  +P++ S         P +ES SP+      P+A      +P   ++
Sbjct: 979  SSIKSSSGAEHP--EPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPP----KPGKLNL 1032

Query: 288  VPIRGVPGQWQGRTSAPATPEIQGR 312
              +  +PG  Q    +   P + GR
Sbjct: 1033 SGV-NLPGVLQQGCVSAKAPVLSGR 1056



 Score = 34.7 bits (78), Expect = 0.25
 Identities = 28/88 (31%), Positives = 35/88 (39%), Gaps = 12/88 (13%)

Query: 192 EESQVPKPPPESPAPP---SRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPY 248
           + S +P P P+ P PP   S   PP       P  P    P   P   SP  + S   P 
Sbjct: 905 QPSSIPVPSPDFPPPPPESSLVFPP------PPPSPVPAPPPPPPPTASPTPDKS-GSPG 957

Query: 249 EKPRKSSEPWSESSSPATTPQDGPSASS 276
           +K  K+S P  +   P  TPQ   S  S
Sbjct: 958 KKTSKTSSPGGK--KPPPTPQRNSSIKS 983



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 60/265 (22%), Positives = 87/265 (32%), Gaps = 40/265 (15%)

Query: 196 VPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSS 255
           VP PPP    PP  P P   +  L+P  P A S  +      P K   + H         
Sbjct: 709 VPPPPP----PPPPPTPGSAMAQLKP-APCAPSLPQFSAPPPPLKIHQVQH--------- 754

Query: 256 EPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGRRGQ 315
                  +P T P   P  + L    P      P+  +P     +T AP           
Sbjct: 755 ---ITQVAPPTPPPPPPIPAPL----PPQAPPKPLVTIPAPTSTKTVAPVV--------- 798

Query: 316 SQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHAACHSCSEDSGSD 375
           +Q+         P  + + AFP    ++   + P    P   P LP      C++   S 
Sbjct: 799 TQAAPPTPTPPVPPAKKQPAFP---ASYIPPSPPTPPVPVPPPTLPKQQSF-CAKPPPSP 854

Query: 376 VSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELVAHHPKLLLPPGYFPAG 435
           +S +       +S     F  P +PP         VPA         P +   P + P+ 
Sbjct: 855 LSPVPSVVKQIAS----QFPPPPTPPAMESQPLKPVPANVAP--QSPPAVKAKPKWQPSS 908

Query: 436 RYVVVAESPLPPGEWELRRAAPGPA 460
             V   + P PP E  L    P P+
Sbjct: 909 IPVPSPDFPPPPPESSLVFPPPPPS 933



 Score = 31.2 bits (69), Expect = 2.7
 Identities = 15/32 (46%), Positives = 16/32 (50%), Gaps = 2/32 (6%)

Query: 197 PKPPPESPAPPSRPLPPQTLEGLQPTGPEAGS 228
           P PPP  P PP  P PP  L     + P AGS
Sbjct: 630 PPPPPPPPPPPPPPPPPPPLP--SQSAPSAGS 659



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 38/137 (27%), Positives = 52/137 (37%), Gaps = 24/137 (17%)

Query: 193 ESQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPR 252
           ESQ  KP P + AP S P   +     QP+     SP+  P    P  E+SL  P   P 
Sbjct: 879 ESQPLKPVPANVAPQSPP-AVKAKPKWQPSSIPVPSPDFPP----PPPESSLVFPPPPP- 932

Query: 253 KSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGR 312
                   S  PA  P   P+AS                G PG+   +TS+P   +    
Sbjct: 933 --------SPVPAPPPPPPPTASP----------TPDKSGSPGKKTSKTSSPGGKKPPPT 974

Query: 313 RGQSQSLRVDSFRAGPE 329
             ++ S++  S    PE
Sbjct: 975 PQRNSSIKSSSGAEHPE 991


>gi|93352554 GPR158-like 1 [Homo sapiens]
          Length = 2367

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 79/277 (28%), Positives = 110/277 (39%), Gaps = 58/277 (20%)

Query: 29   ELTHAVHKQQRALEARLEA---CLEEL-RRLCLREAELTGTLPAEYPLKPGEKAPKVRRR 84
            E T A+HK +   + R E     L+ L RR   ++A  T +  +       E  P +  R
Sbjct: 763  EGTPALHKSRSTYDQRREQDPPLLDSLLRRKLAKKASRTESRESV------EGPPALGFR 816

Query: 85   IGAAYKLD-DWALHREDPLSSLERQLALQLQITEA---ARRLCLEENLSRQARRQRKHSM 140
              +A+ L     L R  P +SL++ L++     +A   A +  LEE   RQA+ +     
Sbjct: 817  SASAHNLTVGERLPRARP-ASLQKSLSVASSREKALLMASQAYLEETY-RQAKER----- 869

Query: 141  LQEEKKLQELQRCLVER--RRNSEPPPAAAL--PLGRELSASDDSSLSDGLLLEEEESQV 196
             +E KK +     LV R   R  E P  A L  P     S+S DSS + G L EE   ++
Sbjct: 870  -EERKKAKAAMASLVRRPSARRLERPRGAPLSAPPSPAKSSSVDSSHTSGRLHEEARRRL 928

Query: 197  PKPPPESPA-----------------PPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPW 239
            P PP                       P+  L P  L  L PT     +P  APV  SP 
Sbjct: 929  PHPPIRHQVSTPILALSGGLGEPRMLSPTSTLAPALLPALAPT----PAPALAPVPVSPQ 984

Query: 240  KETSLDHPYEKPRKSSEPWSESSSPA---TTPQDGPS 273
                L +          PW  +  PA     PQ+GPS
Sbjct: 985  SPNLLTYIC--------PWENAELPAKQENVPQEGPS 1013


>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 49/171 (28%), Positives = 72/171 (42%), Gaps = 18/171 (10%)

Query: 131 QARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDDSSLSDGLLLE 190
           + RR+R+    + EK+ QE +R   ER   +   P+     G  LS +D S L     + 
Sbjct: 519 EKRRRRQERAKEREKRRQERER--KERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMA 576

Query: 191 EEES----QVPKPPPE-SPAP-PSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSL 244
              +     VP P P  +P P P +P  P      QPTGP+   P+ A   + P  + + 
Sbjct: 577 RPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQ---PQSAGSTSGPVPQPAC 633

Query: 245 DHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPG 295
             P   P  +  P      P   P     A+S  LL  A+  +VP  G+PG
Sbjct: 634 PPPGPAPHPTGPP-----GPIPVPAPPQIATSTSLL--AAQSLVPPPGLPG 677


>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 49/171 (28%), Positives = 72/171 (42%), Gaps = 18/171 (10%)

Query: 131 QARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDDSSLSDGLLLE 190
           + RR+R+    + EK+ QE +R   ER   +   P+     G  LS +D S L     + 
Sbjct: 519 EKRRRRQERAKEREKRRQERER--KERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMA 576

Query: 191 EEES----QVPKPPPE-SPAP-PSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSL 244
              +     VP P P  +P P P +P  P      QPTGP+   P+ A   + P  + + 
Sbjct: 577 RPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQ---PQSAGSTSGPVPQPAC 633

Query: 245 DHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPG 295
             P   P  +  P      P   P     A+S  LL  A+  +VP  G+PG
Sbjct: 634 PPPGPAPHPTGPP-----GPIPVPAPPQIATSTSLL--AAQSLVPPPGLPG 677


>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 49/171 (28%), Positives = 72/171 (42%), Gaps = 18/171 (10%)

Query: 131 QARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDDSSLSDGLLLE 190
           + RR+R+    + EK+ QE +R   ER   +   P+     G  LS +D S L     + 
Sbjct: 519 EKRRRRQERAKEREKRRQERER--KERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMA 576

Query: 191 EEES----QVPKPPPE-SPAP-PSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSL 244
              +     VP P P  +P P P +P  P      QPTGP+   P+ A   + P  + + 
Sbjct: 577 RPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQ---PQSAGSTSGPVPQPAC 633

Query: 245 DHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPG 295
             P   P  +  P      P   P     A+S  LL  A+  +VP  G+PG
Sbjct: 634 PPPGPAPHPTGPP-----GPIPVPAPPQIATSTSLL--AAQSLVPPPGLPG 677


>gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo
           sapiens]
          Length = 677

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 49/171 (28%), Positives = 72/171 (42%), Gaps = 18/171 (10%)

Query: 131 QARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDDSSLSDGLLLE 190
           + RR+R+    + EK+ QE +R   ER   +   P+     G  LS +D S L     + 
Sbjct: 380 EKRRRRQERAKEREKRRQERER--KERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMA 437

Query: 191 EEES----QVPKPPPE-SPAP-PSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSL 244
              +     VP P P  +P P P +P  P      QPTGP+   P+ A   + P  + + 
Sbjct: 438 RPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQ---PQSAGSTSGPVPQPAC 494

Query: 245 DHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPG 295
             P   P  +  P      P   P     A+S  LL  A+  +VP  G+PG
Sbjct: 495 PPPGPAPHPTGPP-----GPIPVPAPPQIATSTSLL--AAQSLVPPPGLPG 538


>gi|162951884 R3H domain containing 2 [Homo sapiens]
          Length = 976

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 50/173 (28%), Positives = 68/173 (39%), Gaps = 32/173 (18%)

Query: 165 PAAALPLGREL---SASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGLQP 221
           PAA +P+   +   +  + +S S G L      Q   P  +SP+P S P  PQ   G+ P
Sbjct: 643 PAAGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMP--QSPSPCSPPQMPQQYSGVSP 700

Query: 222 TG----------PEAGSPERAP--VQNSPWKETSLDHPYEKPRKSSEPWSE-------SS 262
           +G          P    P + P  VQ S  K  S+D   +KP     P S        SS
Sbjct: 701 SGPGVVVMQLNVPNGPQPPQNPSMVQWSHCKYYSMDQRGQKPGDLYSPDSSPQANTQMSS 760

Query: 263 SPATTPQDGPSASSLWLLEPASYHVVPI--------RGVPGQWQGRTSAPATP 307
           SP T+P   P+ S +  L      + P+         G P Q  GR S    P
Sbjct: 761 SPVTSPTQSPAPSPVTSLSSVCTGLSPLPVLTQFPRPGGPAQGDGRYSLLGQP 813


>gi|222418647 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 51/205 (24%), Positives = 74/205 (36%), Gaps = 23/205 (11%)

Query: 197 PKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSE 256
           P P   +PAPPS   PP+T     P  P A +  +AP  +S   ET+   P   P  +  
Sbjct: 170 PTPSATTPAPPSSSAPPETTAA--PPTPSATT--QAPPSSSAPPETTAAPP-TPPATTPA 224

Query: 257 PWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGRRGQS 316
           P S S+ P TT    P   S     P S    P           T+ P TP        S
Sbjct: 225 PPSSSAPPETTA--APPTPSATTPAPLSSSAPP---------ETTAVPPTPSATTLDPSS 273

Query: 317 QSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHAACHSCSEDSGSDV 376
            S   ++  A P     +  P   P     T      P + P        + + D+    
Sbjct: 274 ASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPT-------TLAPDTSETS 326

Query: 377 SSISHPTSPGSSSPDISFLQPLSPP 401
           ++ +H T+   ++   +  QP S P
Sbjct: 327 AAPTHQTTTSVTTQTTTTKQPTSAP 351



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 38/125 (30%), Positives = 54/125 (43%), Gaps = 9/125 (7%)

Query: 160 NSEPPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGL 219
           +S PP   A P     +     S S      E  +  P PP  +PAPPS   PP+T    
Sbjct: 182 SSAPPETTAAPPTPSATTQAPPSSSAP---PETTAAPPTPPATTPAPPSSSAPPETTAA- 237

Query: 220 QPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWL 279
            P  P A +P  AP+ +S   ET+   P   P  ++   S +S+P  T    P+ S+   
Sbjct: 238 -PPTPSATTP--APLSSSAPPETTAVPP--TPSATTLDPSSASAPPETTAAPPTPSATTP 292

Query: 280 LEPAS 284
             P+S
Sbjct: 293 APPSS 297



 Score = 37.4 bits (85), Expect = 0.038
 Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 12/122 (9%)

Query: 160 NSEPPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGL 219
           +S PP   A+P     +  D SS S      E  +  P P   +PAPPS P P +T    
Sbjct: 251 SSAPPETTAVPPTPSATTLDPSSASAP---PETTAAPPTPSATTPAPPSSPAPQET---- 303

Query: 220 QPTGPEAGSPERAPVQNSP-WKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLW 278
             T     +P  +P   +P   ETS    ++     +   + +  P + P  G +  S +
Sbjct: 304 --TAAPITTPNSSPTTLAPDTSETSAAPTHQTTTSVTTQTTTTKQPTSAP--GQNKISRF 359

Query: 279 LL 280
           LL
Sbjct: 360 LL 361



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 45/211 (21%), Positives = 78/211 (36%), Gaps = 29/211 (13%)

Query: 197 PKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSE 256
           PK PP    PP  P P Q      P  P+  S    P   +  +  S+  P    + ++ 
Sbjct: 72  PKLPPSPNNPPKFPNPHQ-----PPKHPDKNSSVVNPTLVATTQIPSVTFPSASTKITTL 126

Query: 257 P----WSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGR 312
           P      ++++  ++ ++  ++SS+  L P +             Q  T+AP TP     
Sbjct: 127 PNVTFLPQNATTISSRENVNTSSSVATLAPVNSPAP---------QDTTAAPPTPSATTP 177

Query: 313 RGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHAACHSCSEDS 372
              S S   ++  A P     +  P         T      PAT P  P          S
Sbjct: 178 APPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPPATTPAPP---------SS 228

Query: 373 GSDVSSISHPTSPGSSSPDISFLQPLSPPKT 403
            +   + + P +P +++P  + L   +PP+T
Sbjct: 229 SAPPETTAAPPTPSATTP--APLSSSAPPET 257


>gi|222418649 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 51/205 (24%), Positives = 74/205 (36%), Gaps = 23/205 (11%)

Query: 197 PKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSE 256
           P P   +PAPPS   PP+T     P  P A +  +AP  +S   ET+   P   P  +  
Sbjct: 170 PTPSATTPAPPSSSAPPETTAA--PPTPSATT--QAPPSSSAPPETTAAPP-TPPATTPA 224

Query: 257 PWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGRRGQS 316
           P S S+ P TT    P   S     P S    P           T+ P TP        S
Sbjct: 225 PPSSSAPPETTA--APPTPSATTPAPLSSSAPP---------ETTAVPPTPSATTLDPSS 273

Query: 317 QSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHAACHSCSEDSGSDV 376
            S   ++  A P     +  P   P     T      P + P        + + D+    
Sbjct: 274 ASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPT-------TLAPDTSETS 326

Query: 377 SSISHPTSPGSSSPDISFLQPLSPP 401
           ++ +H T+   ++   +  QP S P
Sbjct: 327 AAPTHQTTTSVTTQTTTTKQPTSAP 351



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 38/125 (30%), Positives = 54/125 (43%), Gaps = 9/125 (7%)

Query: 160 NSEPPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGL 219
           +S PP   A P     +     S S      E  +  P PP  +PAPPS   PP+T    
Sbjct: 182 SSAPPETTAAPPTPSATTQAPPSSSAP---PETTAAPPTPPATTPAPPSSSAPPETTAA- 237

Query: 220 QPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWL 279
            P  P A +P  AP+ +S   ET+   P   P  ++   S +S+P  T    P+ S+   
Sbjct: 238 -PPTPSATTP--APLSSSAPPETTAVPP--TPSATTLDPSSASAPPETTAAPPTPSATTP 292

Query: 280 LEPAS 284
             P+S
Sbjct: 293 APPSS 297



 Score = 37.4 bits (85), Expect = 0.038
 Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 12/122 (9%)

Query: 160 NSEPPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGL 219
           +S PP   A+P     +  D SS S      E  +  P P   +PAPPS P P +T    
Sbjct: 251 SSAPPETTAVPPTPSATTLDPSSASAP---PETTAAPPTPSATTPAPPSSPAPQET---- 303

Query: 220 QPTGPEAGSPERAPVQNSP-WKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLW 278
             T     +P  +P   +P   ETS    ++     +   + +  P + P  G +  S +
Sbjct: 304 --TAAPITTPNSSPTTLAPDTSETSAAPTHQTTTSVTTQTTTTKQPTSAP--GQNKISRF 359

Query: 279 LL 280
           LL
Sbjct: 360 LL 361



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 45/211 (21%), Positives = 78/211 (36%), Gaps = 29/211 (13%)

Query: 197 PKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSE 256
           PK PP    PP  P P Q      P  P+  S    P   +  +  S+  P    + ++ 
Sbjct: 72  PKLPPSPNNPPKFPNPHQ-----PPKHPDKNSSVVNPTLVATTQIPSVTFPSASTKITTL 126

Query: 257 P----WSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGR 312
           P      ++++  ++ ++  ++SS+  L P +             Q  T+AP TP     
Sbjct: 127 PNVTFLPQNATTISSRENVNTSSSVATLAPVNSPAP---------QDTTAAPPTPSATTP 177

Query: 313 RGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHAACHSCSEDS 372
              S S   ++  A P     +  P         T      PAT P  P          S
Sbjct: 178 APPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPPATTPAPP---------SS 228

Query: 373 GSDVSSISHPTSPGSSSPDISFLQPLSPPKT 403
            +   + + P +P +++P  + L   +PP+T
Sbjct: 229 SAPPETTAAPPTPSATTP--APLSSSAPPET 257


>gi|222418645 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 51/205 (24%), Positives = 74/205 (36%), Gaps = 23/205 (11%)

Query: 197 PKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSE 256
           P P   +PAPPS   PP+T     P  P A +  +AP  +S   ET+   P   P  +  
Sbjct: 170 PTPSATTPAPPSSSAPPETTAA--PPTPSATT--QAPPSSSAPPETTAAPP-TPPATTPA 224

Query: 257 PWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGRRGQS 316
           P S S+ P TT    P   S     P S    P           T+ P TP        S
Sbjct: 225 PPSSSAPPETTA--APPTPSATTPAPLSSSAPP---------ETTAVPPTPSATTLDPSS 273

Query: 317 QSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHAACHSCSEDSGSDV 376
            S   ++  A P     +  P   P     T      P + P        + + D+    
Sbjct: 274 ASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPT-------TLAPDTSETS 326

Query: 377 SSISHPTSPGSSSPDISFLQPLSPP 401
           ++ +H T+   ++   +  QP S P
Sbjct: 327 AAPTHQTTTSVTTQTTTTKQPTSAP 351



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 38/125 (30%), Positives = 54/125 (43%), Gaps = 9/125 (7%)

Query: 160 NSEPPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGL 219
           +S PP   A P     +     S S      E  +  P PP  +PAPPS   PP+T    
Sbjct: 182 SSAPPETTAAPPTPSATTQAPPSSSAP---PETTAAPPTPPATTPAPPSSSAPPETTAA- 237

Query: 220 QPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWL 279
            P  P A +P  AP+ +S   ET+   P   P  ++   S +S+P  T    P+ S+   
Sbjct: 238 -PPTPSATTP--APLSSSAPPETTAVPP--TPSATTLDPSSASAPPETTAAPPTPSATTP 292

Query: 280 LEPAS 284
             P+S
Sbjct: 293 APPSS 297



 Score = 37.4 bits (85), Expect = 0.038
 Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 12/122 (9%)

Query: 160 NSEPPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGL 219
           +S PP   A+P     +  D SS S      E  +  P P   +PAPPS P P +T    
Sbjct: 251 SSAPPETTAVPPTPSATTLDPSSASAP---PETTAAPPTPSATTPAPPSSPAPQET---- 303

Query: 220 QPTGPEAGSPERAPVQNSP-WKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLW 278
             T     +P  +P   +P   ETS    ++     +   + +  P + P  G +  S +
Sbjct: 304 --TAAPITTPNSSPTTLAPDTSETSAAPTHQTTTSVTTQTTTTKQPTSAP--GQNKISRF 359

Query: 279 LL 280
           LL
Sbjct: 360 LL 361



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 45/211 (21%), Positives = 78/211 (36%), Gaps = 29/211 (13%)

Query: 197 PKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSE 256
           PK PP    PP  P P Q      P  P+  S    P   +  +  S+  P    + ++ 
Sbjct: 72  PKLPPSPNNPPKFPNPHQ-----PPKHPDKNSSVVNPTLVATTQIPSVTFPSASTKITTL 126

Query: 257 P----WSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGR 312
           P      ++++  ++ ++  ++SS+  L P +             Q  T+AP TP     
Sbjct: 127 PNVTFLPQNATTISSRENVNTSSSVATLAPVNSPAP---------QDTTAAPPTPSATTP 177

Query: 313 RGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHAACHSCSEDS 372
              S S   ++  A P     +  P         T      PAT P  P          S
Sbjct: 178 APPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPPATTPAPP---------SS 228

Query: 373 GSDVSSISHPTSPGSSSPDISFLQPLSPPKT 403
            +   + + P +P +++P  + L   +PP+T
Sbjct: 229 SAPPETTAAPPTPSATTP--APLSSSAPPET 257


>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
          Length = 2390

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 52/190 (27%), Positives = 76/190 (40%), Gaps = 38/190 (20%)

Query: 103  SSLERQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSE 162
            S ++R  A Q        R C  E L+    R+++    +EE++          R++   
Sbjct: 2050 SLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEE---------RRKQPPA 2100

Query: 163  PPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPPESPAP----------PSRP-L 211
            P P A++P G  +     S  +        +   P+PPP + AP          PS+P L
Sbjct: 2101 PEPTASVPPGDLVGGQTASDTT-------WDGTQPRPPPSTQAPSVNGVCTDGEPSQPLL 2153

Query: 212  PPQTLEGLQ-PTGPEAGSPERAPVQNSPWKE----TSLDHPYEKPRKSSEPWSESSSPAT 266
              Q LE    P GP  GS + A   N P  E    T    P   P+  S   +ES+  AT
Sbjct: 2154 GQQRLEHSSFPEGPGPGSGDEA---NGPRGERQTRTRGPAPSAMPQSRS---TESAHAAT 2207

Query: 267  TPQDGPSASS 276
             P  GP  S+
Sbjct: 2208 LPPRGPEPSA 2217


>gi|122937271 WAS protein homolog associated with actin, golgi
           membranes and microtubules [Homo sapiens]
          Length = 809

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 27/72 (37%), Positives = 34/72 (47%), Gaps = 3/72 (4%)

Query: 191 EEESQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPE---RAPVQNSPWKETSLDHP 247
           EE S  P PPP  P PP  P PP  L  L  +   A       RAPV++   +    + P
Sbjct: 634 EELSLPPPPPPPPPPPPPPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPRPLVCESP 693

Query: 248 YEKPRKSSEPWS 259
            E+PR S E +S
Sbjct: 694 AERPRDSLESFS 705


>gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]
          Length = 1120

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 56/197 (28%), Positives = 74/197 (37%), Gaps = 51/197 (25%)

Query: 151  QRCLVERRRNSEPP--PAAALPL--------GRELSASDDSSLSDGLLLEEEESQVPK-- 198
            +R L E    SEPP  PA A P         G E +     S  +GL   EE +   K  
Sbjct: 822  RRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQR 881

Query: 199  PPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPV--QNSPWKETSLDHPYEKPRKSSE 256
            P P  P P   P+PP    GL     E+ + +R P   +  P +   L         S+ 
Sbjct: 882  PKPAGPPPRETPVPP----GLDFNLTESDTVKRRPKCREREPLQTALLAFGVA----SAT 933

Query: 257  PWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVP---------------------- 294
            P   +  P+ TP + P ASSL   EP+S   +P +GVP                      
Sbjct: 934  PGPAAPLPSPTPGESPPASSLPQPEPSS---LPAQGVPTPLAPSPAMQPPVPPCPGPGLE 990

Query: 295  ----GQWQGRTSAPATP 307
                 +W G T  PA P
Sbjct: 991  SSAASRWNGETEPPAAP 1007



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 96/382 (25%), Positives = 128/382 (33%), Gaps = 56/382 (14%)

Query: 102 LSSLERQLALQLQITEAARRLCLE---------ENLSRQARRQRKHSMLQEEKKLQELQR 152
           L+ L R L     ++E  RRL            EN    A    +    Q  +   ELQ 
Sbjct: 537 LAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQA 596

Query: 153 CLVERRRNSEPPPAAALPLGRELSA-SDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPL 211
            +        P P A  P    + A S  S  S      +     P PP E   P     
Sbjct: 597 AMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTER 656

Query: 212 PPQTLEGLQPTGP----------EAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSES 261
           PP+    L   GP             SP   P   +PW  + L  P   P     P   S
Sbjct: 657 PPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRS 716

Query: 262 ---SSPATTPQD------GPSASSLWLLEPASYHVVPIRGVPGQWQ-GRTSAPATPEIQG 311
              S P  T  D      GP  S+L      SY  +  R  PG+    RTS   TP    
Sbjct: 717 HSLSRPGPTEGDAEGEAEGPVGSTL-----GSYATLTRR--PGRSALVRTSPSVTPTPAR 769

Query: 312 RRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHAAC-----H 366
              +SQS  + + R GP        P +R +  +   P+   P  + P P          
Sbjct: 770 GTPRSQSFALRARRKGPPPP-----PPKRLSSVSGPSPEPP-PLDESPGPKEGATGPRRR 823

Query: 367 SCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELVAHHPKLL 426
           + SE +G   S    P +P   + D    +P  P  T   RG+   +G     A    L 
Sbjct: 824 TLSEPAGP--SEPPGPPAPAGPASDTEEEEP-GPEGTPPSRGS---SGEGLPFAEEGNLT 877

Query: 427 LPPGYFPAGRYVVVAESPLPPG 448
           +     PAG      E+P+PPG
Sbjct: 878 IKQRPKPAG--PPPRETPVPPG 897


>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
          Length = 1202

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 56/197 (28%), Positives = 74/197 (37%), Gaps = 51/197 (25%)

Query: 151  QRCLVERRRNSEPP--PAAALPL--------GRELSASDDSSLSDGLLLEEEESQVPK-- 198
            +R L E    SEPP  PA A P         G E +     S  +GL   EE +   K  
Sbjct: 904  RRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQR 963

Query: 199  PPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPV--QNSPWKETSLDHPYEKPRKSSE 256
            P P  P P   P+PP    GL     E+ + +R P   +  P +   L         S+ 
Sbjct: 964  PKPAGPPPRETPVPP----GLDFNLTESDTVKRRPKCREREPLQTALLAFGVA----SAT 1015

Query: 257  PWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVP---------------------- 294
            P   +  P+ TP + P ASSL   EP+S   +P +GVP                      
Sbjct: 1016 PGPAAPLPSPTPGESPPASSLPQPEPSS---LPAQGVPTPLAPSPAMQPPVPPCPGPGLE 1072

Query: 295  ----GQWQGRTSAPATP 307
                 +W G T  PA P
Sbjct: 1073 SSAASRWNGETEPPAAP 1089



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 96/382 (25%), Positives = 128/382 (33%), Gaps = 56/382 (14%)

Query: 102 LSSLERQLALQLQITEAARRLCLE---------ENLSRQARRQRKHSMLQEEKKLQELQR 152
           L+ L R L     ++E  RRL            EN    A    +    Q  +   ELQ 
Sbjct: 619 LAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQA 678

Query: 153 CLVERRRNSEPPPAAALPLGRELSA-SDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPL 211
            +        P P A  P    + A S  S  S      +     P PP E   P     
Sbjct: 679 AMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTER 738

Query: 212 PPQTLEGLQPTGP----------EAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSES 261
           PP+    L   GP             SP   P   +PW  + L  P   P     P   S
Sbjct: 739 PPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRS 798

Query: 262 ---SSPATTPQD------GPSASSLWLLEPASYHVVPIRGVPGQWQ-GRTSAPATPEIQG 311
              S P  T  D      GP  S+L      SY  +  R  PG+    RTS   TP    
Sbjct: 799 HSLSRPGPTEGDAEGEAEGPVGSTL-----GSYATLTRR--PGRSALVRTSPSVTPTPAR 851

Query: 312 RRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHAAC-----H 366
              +SQS  + + R GP        P +R +  +   P+   P  + P P          
Sbjct: 852 GTPRSQSFALRARRKGPPPP-----PPKRLSSVSGPSPEPP-PLDESPGPKEGATGPRRR 905

Query: 367 SCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELVAHHPKLL 426
           + SE +G   S    P +P   + D    +P  P  T   RG+   +G     A    L 
Sbjct: 906 TLSEPAGP--SEPPGPPAPAGPASDTEEEEP-GPEGTPPSRGS---SGEGLPFAEEGNLT 959

Query: 427 LPPGYFPAGRYVVVAESPLPPG 448
           +     PAG      E+P+PPG
Sbjct: 960 IKQRPKPAG--PPPRETPVPPG 979


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 44/161 (27%), Positives = 58/161 (36%), Gaps = 35/161 (21%)

Query: 106 ERQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSE--- 162
           ERQ   + +  E   RL  +E L RQ R  R+    QE ++L+ L+R   ER R  +   
Sbjct: 194 ERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLER 253

Query: 163 ---------------PPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPK--------- 198
                           P +   PL   L   D S+   GL    + ++ P          
Sbjct: 254 EQLEWERERRISSAAAPASVETPLNSVLG--DSSASEPGLQAASQPAETPSQQGIVLGPL 311

Query: 199 -PPPESPAPP-----SRPLPPQTLEGLQPTGPEAGSPERAP 233
            PPP  P PP     S  LPP       P  P  G P   P
Sbjct: 312 APPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPP 352


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 44/161 (27%), Positives = 58/161 (36%), Gaps = 35/161 (21%)

Query: 106 ERQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSE--- 162
           ERQ   + +  E   RL  +E L RQ R  R+    QE ++L+ L+R   ER R  +   
Sbjct: 194 ERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLER 253

Query: 163 ---------------PPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPK--------- 198
                           P +   PL   L   D S+   GL    + ++ P          
Sbjct: 254 EQLEWERERRISSAAAPASVETPLNSVLG--DSSASEPGLQAASQPAETPSQQGIVLGPL 311

Query: 199 -PPPESPAPP-----SRPLPPQTLEGLQPTGPEAGSPERAP 233
            PPP  P PP     S  LPP       P  P  G P   P
Sbjct: 312 APPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPP 352


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.131    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,194,158
Number of Sequences: 37866
Number of extensions: 1907295
Number of successful extensions: 16569
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 184
Number of HSP's successfully gapped in prelim test: 1080
Number of HSP's that attempted gapping in prelim test: 11026
Number of HSP's gapped (non-prelim): 4590
length of query: 578
length of database: 18,247,518
effective HSP length: 108
effective length of query: 470
effective length of database: 14,157,990
effective search space: 6654255300
effective search space used: 6654255300
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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