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Search of human proteins with 21687020
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21687020 ecotropic viral integration site 5-like isoform 2
[Homo sapiens]
(794 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 1546 0.0
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 1538 0.0
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 739 0.0
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 258 2e-68
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 244 2e-64
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 189 7e-48
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 180 5e-45
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 147 5e-35
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 147 5e-35
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 146 6e-35
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 141 2e-33
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 135 1e-31
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 124 3e-28
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 122 2e-27
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 118 2e-26
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 116 9e-26
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso... 115 2e-25
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso... 115 2e-25
gi|148806902 TBC1 domain family, member 12 [Homo sapiens] 111 2e-24
gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 111 3e-24
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 108 3e-23
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 105 1e-22
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens] 103 8e-22
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens] 103 8e-22
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens] 103 8e-22
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 93 1e-18
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 89 1e-17
gi|226693407 TBC1 domain family, member 3H [Homo sapiens] 85 2e-16
gi|157502205 TBC1 domain family, member 3G [Homo sapiens] 85 2e-16
gi|14149985 TBC1 domain family, member 3F [Homo sapiens] 85 3e-16
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 1546 bits (4004), Expect = 0.0
Identities = 794/794 (100%), Positives = 794/794 (100%)
Query: 1 MASPTLSPDSSSQEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNG 60
MASPTLSPDSSSQEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNG
Sbjct: 1 MASPTLSPDSSSQEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNG 60
Query: 61 SRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHF 120
SRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHF
Sbjct: 61 SRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHF 120
Query: 121 RAIVWQLLCSATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLF 180
RAIVWQLLCSATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLF
Sbjct: 121 RAIVWQLLCSATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLF 180
Query: 181 NVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELG 240
NVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELG
Sbjct: 181 NVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELG 240
Query: 241 LCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEG 300
LCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEG
Sbjct: 241 LCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEG 300
Query: 301 LEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKM 360
LEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKM
Sbjct: 301 LEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKM 360
Query: 361 KRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKGQVTRAQEAEENYVIKRELA 420
KRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKGQVTRAQEAEENYVIKRELA
Sbjct: 361 KRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKGQVTRAQEAEENYVIKRELA 420
Query: 421 VVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLETELEQSRLRETETLGALRE 480
VVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLETELEQSRLRETETLGALRE
Sbjct: 421 VVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLETELEQSRLRETETLGALRE 480
Query: 481 MQDKVLDMEKRNSSLPDENNVAQLQEELKALKVREGQAVASTRELKLQLQELSDTWQAHL 540
MQDKVLDMEKRNSSLPDENNVAQLQEELKALKVREGQAVASTRELKLQLQELSDTWQAHL
Sbjct: 481 MQDKVLDMEKRNSSLPDENNVAQLQEELKALKVREGQAVASTRELKLQLQELSDTWQAHL 540
Query: 541 ARGGRWKESPRKLVVGELQDELMSVRLREAQALAEGRELRQRVVELETQDHIHRNLLNRV 600
ARGGRWKESPRKLVVGELQDELMSVRLREAQALAEGRELRQRVVELETQDHIHRNLLNRV
Sbjct: 541 ARGGRWKESPRKLVVGELQDELMSVRLREAQALAEGRELRQRVVELETQDHIHRNLLNRV 600
Query: 601 EAERAALQEKLQYLAAQNKGLQTQLSESRRKQAEAECKSKEEVMAVRLREADSMAAVAEM 660
EAERAALQEKLQYLAAQNKGLQTQLSESRRKQAEAECKSKEEVMAVRLREADSMAAVAEM
Sbjct: 601 EAERAALQEKLQYLAAQNKGLQTQLSESRRKQAEAECKSKEEVMAVRLREADSMAAVAEM 660
Query: 661 RQRIAELEIQREEGRIQGQLNHSDSSQYIRELKDQIEELKAEVRLLKGPPPFEDPLAFDG 720
RQRIAELEIQREEGRIQGQLNHSDSSQYIRELKDQIEELKAEVRLLKGPPPFEDPLAFDG
Sbjct: 661 RQRIAELEIQREEGRIQGQLNHSDSSQYIRELKDQIEELKAEVRLLKGPPPFEDPLAFDG 720
Query: 721 LSLARHLDEDSLPSSDEELLGVGVGAALQDALYPLSPRDARFFRRLERPAKDSEGSSDSD 780
LSLARHLDEDSLPSSDEELLGVGVGAALQDALYPLSPRDARFFRRLERPAKDSEGSSDSD
Sbjct: 721 LSLARHLDEDSLPSSDEELLGVGVGAALQDALYPLSPRDARFFRRLERPAKDSEGSSDSD 780
Query: 781 ADELAAPYSQGLDN 794
ADELAAPYSQGLDN
Sbjct: 781 ADELAAPYSQGLDN 794
>gi|229577000 ecotropic viral integration site 5-like isoform 1
[Homo sapiens]
Length = 805
Score = 1538 bits (3982), Expect = 0.0
Identities = 794/805 (98%), Positives = 794/805 (98%), Gaps = 11/805 (1%)
Query: 1 MASPTLSPDSSSQEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNG 60
MASPTLSPDSSSQEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNG
Sbjct: 1 MASPTLSPDSSSQEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNG 60
Query: 61 SRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHF 120
SRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHF
Sbjct: 61 SRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHF 120
Query: 121 RAIVWQLLCSATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLF 180
RAIVWQLLCSATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLF
Sbjct: 121 RAIVWQLLCSATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLF 180
Query: 181 NVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELG 240
NVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELG
Sbjct: 181 NVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELG 240
Query: 241 LCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEG 300
LCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEG
Sbjct: 241 LCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEG 300
Query: 301 LEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKM 360
LEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKM
Sbjct: 301 LEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKM 360
Query: 361 KRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEK-----------GQVTRAQEA 409
KRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEK GQVTRAQEA
Sbjct: 361 KRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKESAALADRLIQGQVTRAQEA 420
Query: 410 EENYVIKRELAVVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLETELEQSRL 469
EENYVIKRELAVVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLETELEQSRL
Sbjct: 421 EENYVIKRELAVVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLETELEQSRL 480
Query: 470 RETETLGALREMQDKVLDMEKRNSSLPDENNVAQLQEELKALKVREGQAVASTRELKLQL 529
RETETLGALREMQDKVLDMEKRNSSLPDENNVAQLQEELKALKVREGQAVASTRELKLQL
Sbjct: 481 RETETLGALREMQDKVLDMEKRNSSLPDENNVAQLQEELKALKVREGQAVASTRELKLQL 540
Query: 530 QELSDTWQAHLARGGRWKESPRKLVVGELQDELMSVRLREAQALAEGRELRQRVVELETQ 589
QELSDTWQAHLARGGRWKESPRKLVVGELQDELMSVRLREAQALAEGRELRQRVVELETQ
Sbjct: 541 QELSDTWQAHLARGGRWKESPRKLVVGELQDELMSVRLREAQALAEGRELRQRVVELETQ 600
Query: 590 DHIHRNLLNRVEAERAALQEKLQYLAAQNKGLQTQLSESRRKQAEAECKSKEEVMAVRLR 649
DHIHRNLLNRVEAERAALQEKLQYLAAQNKGLQTQLSESRRKQAEAECKSKEEVMAVRLR
Sbjct: 601 DHIHRNLLNRVEAERAALQEKLQYLAAQNKGLQTQLSESRRKQAEAECKSKEEVMAVRLR 660
Query: 650 EADSMAAVAEMRQRIAELEIQREEGRIQGQLNHSDSSQYIRELKDQIEELKAEVRLLKGP 709
EADSMAAVAEMRQRIAELEIQREEGRIQGQLNHSDSSQYIRELKDQIEELKAEVRLLKGP
Sbjct: 661 EADSMAAVAEMRQRIAELEIQREEGRIQGQLNHSDSSQYIRELKDQIEELKAEVRLLKGP 720
Query: 710 PPFEDPLAFDGLSLARHLDEDSLPSSDEELLGVGVGAALQDALYPLSPRDARFFRRLERP 769
PPFEDPLAFDGLSLARHLDEDSLPSSDEELLGVGVGAALQDALYPLSPRDARFFRRLERP
Sbjct: 721 PPFEDPLAFDGLSLARHLDEDSLPSSDEELLGVGVGAALQDALYPLSPRDARFFRRLERP 780
Query: 770 AKDSEGSSDSDADELAAPYSQGLDN 794
AKDSEGSSDSDADELAAPYSQGLDN
Sbjct: 781 AKDSEGSSDSDADELAAPYSQGLDN 805
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 739 bits (1909), Expect = 0.0
Identities = 418/764 (54%), Positives = 525/764 (68%), Gaps = 86/764 (11%)
Query: 1 MASPTLSPDSS-----SQEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSM 55
MAS SP +S S LS P SP+S S+ LSPD+LELLAKLEEQNRLLE DSKS+
Sbjct: 45 MASQVASPSTSLHTTSSSTTLSTPALSPSSPSQ-LSPDDLELLAKLEEQNRLLETDSKSL 103
Query: 56 RSMNGSRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKG 115
RS+NGSRRNSGSSLVSSSSASSNLSHLEED+WILWGRI NEWE+ R++KEK +KEL+ KG
Sbjct: 104 RSVNGSRRNSGSSLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKG 163
Query: 116 IPHHFRAIVWQLLCSATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLG 175
IPHHFRAIVWQLLCSA MP+K+QYSELLKM+SPCEKLIRRDIARTYPEH FFK +DSLG
Sbjct: 164 IPHHFRAIVWQLLCSAQSMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLG 223
Query: 176 QEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPS 235
QEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFV+LMQ+YRLRELFKPS
Sbjct: 224 QEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPS 283
Query: 236 MAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDI 295
MAELGLC+YQFE M+QE LP+L HF+SQSFHTSMYASSWFLT+FLTTFPLP+ATR+FDI
Sbjct: 284 MAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDI 343
Query: 296 FMYEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKY 355
FM EGLEIVFRVGLALLQ+NQAELMQLDMEGM Q+FQ+VIPHQFD PDKL+ AYQVKY
Sbjct: 344 FMSEGLEIVFRVGLALLQMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKY 403
Query: 356 NPKKMKRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKGQVTRAQEAEENYVI 415
N KKMK+LEKEY +K+KEMEEQ+EIKRLRTENRLLKQRIETLEK + + E++V+
Sbjct: 404 NSKKMKKLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRIETLEKHKC--SSNYNEDFVL 461
Query: 416 KRELAVVRQQCSSAAED--LQKAQSTIRQLQEQQENPRLTEDFVSHLETELEQSRLRETE 473
+ E +V+ + S A L++ Q + + E++ N E+ ++ L+ EL +LRE E
Sbjct: 462 QLEKELVQARLSEAESQCALKEMQDKVLDI-EKRNNSLPDENNIARLQEELIAVKLREAE 520
Query: 474 TLGALREMQDKVLDMEK-----------RNSSLPDENNVAQLQEELKALKVREGQAVAST 522
+ L+E++ +V D+E+ R P +N + +LQ+EL +++RE + A
Sbjct: 521 AIMGLKELRQQVKDLEEHWQRHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEI 580
Query: 523 RELKLQLQELSDTWQA---HLARGGRWKESPRKLVVGELQDELMSVRLREAQALAEGREL 579
RE+K ++ E+ Q HL R + V LQ+++ + + L + E
Sbjct: 581 REIKQRMMEMETQNQINSNHLRRA--------EQEVISLQEKVQYLSAQNKGLLTQLSEA 632
Query: 580 RQRVVELETQDHIHRNLLNRVEAER-AALQEKLQYLAAQNKGLQTQLSESRRKQAEAECK 638
+++ E+E ++ + EA+ AA+ E Q++A E E +
Sbjct: 633 KRKQAEIECKNKEEVMAVRLREADSIAAVAELRQHIA------------------ELEIQ 674
Query: 639 SKEEVMAVRLREADSMAAVAEMRQRIAELEIQREEGRIQGQLNHSDSSQYIRELKDQIEE 698
+E + +L ++DS + E++ +IAE LNH
Sbjct: 675 KEEGKLQGQLNKSDSNQYIGELKDQIAE-------------LNH---------------- 705
Query: 699 LKAEVRLLKGPPPFEDPLAFDGLSLARHL--DEDSLPSSDEELL 740
E+R LKG F FDG+ + HL D++S SSDE+ +
Sbjct: 706 ---ELRCLKGQRGFSGQPPFDGIHIVNHLIGDDESFHSSDEDFI 746
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 258 bits (659), Expect = 2e-68
Identities = 179/554 (32%), Positives = 285/554 (51%), Gaps = 45/554 (8%)
Query: 65 SGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIV 124
SGS VS A L WG + ++W + K L L+R G+P R V
Sbjct: 524 SGSGDVSKECAEKILE--------TWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEV 575
Query: 125 WQLL--CSATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNV 182
WQLL C D V+ +Y L+ SP + I RDI RT+P H++FK GQ+ L+ +
Sbjct: 576 WQLLAGCHNNDHLVE-KYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKI 634
Query: 183 MKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLC 242
KAYS+ D E+GYCQG +F+ +LL+ MPEE+AF V V++M +Y LRELFK + +L
Sbjct: 635 CKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCK 694
Query: 243 IYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLE 302
YQ E ++QE +PDL HF S MYAS WFLTLF FPL + + D+ + EG+
Sbjct: 695 FYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGIS 754
Query: 303 IVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPD--KLVLKAYQVKYNPKKM 360
++F V L LL+ ++ +L+ D EG ++F+ +P ++ S + KL+ A +K + KK+
Sbjct: 755 VIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKL 814
Query: 361 KRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKGQVTRAQE-AEENYVIKREL 419
K+ EKEY M+ ++ +++ I+R ENR L++ LE+ A E ++++L
Sbjct: 815 KKYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDL 874
Query: 420 AVVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLETELEQSRLRETETLGALR 479
++ + ++L + + + ++E RL E E ++L+E R
Sbjct: 875 DNAEEKADALNKELLMTKQKL--IDAEEEKRRLEE----------ESAQLKEM----CRR 918
Query: 480 EMQDKVLDMEKRNSSLPDENNV-AQLQEELKALKVREGQAVASTRELKLQLQELSDTWQA 538
E+ +++K +S + D + +QL E L E Q A+ E++ Q++ D +
Sbjct: 919 ELDKAESEIKKNSSIIGDYKQICSQLSERL------EKQQTANKVEIEKIRQKVDDCERC 972
Query: 539 H--LARGGRWKE-SPRKLVVGELQD---ELMSVRLREAQALAEGRELRQRVVELETQDHI 592
+ GR K S K V+ E D E + +LRE + +L+ E + QD
Sbjct: 973 REFFNKEGRVKGISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLE 1032
Query: 593 HR--NLLNRVEAER 604
H LN V+A +
Sbjct: 1033 HHLGLALNEVQAAK 1046
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 244 bits (623), Expect = 2e-64
Identities = 117/299 (39%), Positives = 185/299 (61%), Gaps = 3/299 (1%)
Query: 90 WGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATD-MPVKNQYSELLKMSS 148
WG + +W + K L L++ G+P RA VWQLL D + ++Y L+ S
Sbjct: 513 WGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDS 572
Query: 149 PCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLM 208
E +I RDI RT+P H++FK GQE L+ + KAYS+ D ++GYCQG +F+ +LL+
Sbjct: 573 AQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLL 632
Query: 209 QMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHT 268
MPEE+AFCV V++M +Y LR+L++ + +L YQ E ++QEQLPDL++HF +
Sbjct: 633 HMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEA 692
Query: 269 SMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMS 328
MYAS WFLTLF FPL + + D+ + EGL I+F V LALL+ ++ +L+Q D EG
Sbjct: 693 HMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGAL 752
Query: 329 QYFQRVIPHQF--DSCPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIKRLR 385
++F+ +P ++ + +L+ +A +K KK+K+ EKEY M+ +++++ + R +
Sbjct: 753 KFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQEDPMDRYK 811
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 189 bits (481), Expect = 7e-48
Identities = 129/455 (28%), Positives = 219/455 (48%), Gaps = 48/455 (10%)
Query: 37 LLAKLEEQNRLLEADSKSMRSMNGSRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANE 96
LL ++E++N+ LEA ++S + +++ I W +
Sbjct: 852 LLLRMEKENQKLEASRDELQSRK------------VKLDYEEVGACQKEVLITWDKKLLN 899
Query: 97 WEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDM----PVKNQ-----YSELLKMS 147
R + + L+++G+P R +WQ L + P K Q Y ELLK
Sbjct: 900 CRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQL 959
Query: 148 SPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLL 207
+ + I D+ RT+P H +F Q GQ LFN++KAYSL+D+EVGYCQG +F+ G+LL
Sbjct: 960 TAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLL 1019
Query: 208 MQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFH 267
+ M EE+AF + LM + R+ ++P M L + +YQ +L + DL H
Sbjct: 1020 LHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEIS 1079
Query: 268 TSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLD-MEG 326
S+YA+ WFLTLF + F L RVFDI +G E++F+V L+LL + +M+ + E
Sbjct: 1080 PSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFEN 1139
Query: 327 MSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIKRLRT 386
+ ++ + +P S +K++ + +++ + K++ E EY ++ + E
Sbjct: 1140 IVEFLKNTLPDMNTSEMEKIITQVFEMDIS-KQLHAYEVEYHVLQDELQESSYSC----- 1193
Query: 387 ENRLLKQRIETLEKGQVTRAQEAEENYVIKRELAVVRQQCSSAAEDLQKAQSTIRQLQEQ 446
+ ETLEK ++R + +++Q E LQ A + I+ L+
Sbjct: 1194 ------EDSETLEK--------------LERANSQLKRQNMDLLEKLQVAHTKIQALESN 1233
Query: 447 QENPRLTEDFVSHLETELEQSRLRETETLGALREM 481
EN E + L LEQ ++ +T+ LR++
Sbjct: 1234 LENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKL 1268
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 180 bits (456), Expect = 5e-45
Identities = 116/371 (31%), Positives = 195/371 (52%), Gaps = 35/371 (9%)
Query: 112 IRKGIPHHFRAIVWQLLCSATDM----PVKNQ-----YSELLKMSSPCEKLIRRDIARTY 162
+ +G+P H R +W+ L + P K Q Y ELLK + + I D+ RT+
Sbjct: 797 VGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTF 856
Query: 163 PEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRL 222
P H +F Q GQ L+N++KAYSL+D+EVGYCQG +F+ G+LL+ M EEEAF + L
Sbjct: 857 PTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFL 916
Query: 223 MQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLT 282
M + LR+ ++P M L + +YQ +L + DL H S+YA+ WFLT+F +
Sbjct: 917 MFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFAS 976
Query: 283 TFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLD-MEGMSQYFQRVIPHQFDS 341
FPL RVFD+ +G E++F+V L+LL ++ ++Q + +E + + + +P+
Sbjct: 977 QFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLV 1036
Query: 342 CPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKG 401
+K + + +++ K+++ E EY ++ EE I+ L QR++ LEK
Sbjct: 1037 QMEKTINQVFEMDI-AKQLQAYEVEYHVLQ----EELIDSSPLSD-----NQRMDKLEK- 1085
Query: 402 QVTRAQEAEENYVIKRELAVVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLE 461
T + ++N + +L V + S ++K S+ +L++ + L
Sbjct: 1086 --TNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQ------------AMLT 1131
Query: 462 TELEQSRLRET 472
ELE+S L +T
Sbjct: 1132 LELERSALLQT 1142
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 147 bits (370), Expect = 5e-35
Identities = 90/291 (30%), Positives = 148/291 (50%), Gaps = 10/291 (3%)
Query: 81 HLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMP--VKN 138
HLE + W ++ WE+++ ++ I KGIP R VW LL M ++
Sbjct: 68 HLEIERTTKWLKMLKGWEKYKNTEK--FHRRIYKGIPLQLRGEVWALLLEIPKMKEETRD 125
Query: 139 QYSELLKMSSPCEKLIRR---DIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGY 195
YS+L + C IR+ D+ RT+ +H F+ + + Q+ LF+V+ AYS+ + EVGY
Sbjct: 126 LYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGY 185
Query: 196 CQGSAFIVGLLLMQMPEEEAFCVFVRLMQ--EYRLRELFKPSMAELGLCIYQFEYMLQEQ 253
CQG + I LLLM M EE+AF V+L ++ + F +L E +L +
Sbjct: 186 CQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKF 245
Query: 254 LPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQ 313
L L H SQ +TS Y WF FL P + R++DI+++EG ++ + +L+
Sbjct: 246 LSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILK 305
Query: 314 VNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRLE 364
+++ LM+L ME + ++FQ + F D V++ Q+ K +L+
Sbjct: 306 LHKKHLMKLSMEELVEFFQETLAKDF-FFEDDFVIEQLQISMTELKRAKLD 355
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 147 bits (370), Expect = 5e-35
Identities = 90/291 (30%), Positives = 148/291 (50%), Gaps = 10/291 (3%)
Query: 81 HLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMP--VKN 138
HLE + W ++ WE+++ ++ I KGIP R VW LL M ++
Sbjct: 85 HLEIERTTKWLKMLKGWEKYKNTEK--FHRRIYKGIPLQLRGEVWALLLEIPKMKEETRD 142
Query: 139 QYSELLKMSSPCEKLIRR---DIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGY 195
YS+L + C IR+ D+ RT+ +H F+ + + Q+ LF+V+ AYS+ + EVGY
Sbjct: 143 LYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGY 202
Query: 196 CQGSAFIVGLLLMQMPEEEAFCVFVRLMQ--EYRLRELFKPSMAELGLCIYQFEYMLQEQ 253
CQG + I LLLM M EE+AF V+L ++ + F +L E +L +
Sbjct: 203 CQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKF 262
Query: 254 LPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQ 313
L L H SQ +TS Y WF FL P + R++DI+++EG ++ + +L+
Sbjct: 263 LSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILK 322
Query: 314 VNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRLE 364
+++ LM+L ME + ++FQ + F D V++ Q+ K +L+
Sbjct: 323 LHKKHLMKLSMEELVEFFQETLAKDF-FFEDDFVIEQLQISMTELKRAKLD 372
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 146 bits (369), Expect = 6e-35
Identities = 112/401 (27%), Positives = 189/401 (47%), Gaps = 26/401 (6%)
Query: 3 SPTLSPDSSSQEALSAPTCSP-TSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNGS 61
+P P +SQ+ S + P S +PD L L + + LE+ + + SM
Sbjct: 234 TPAPEPAENSQDLGSTSSLGPGISGPRGQAPDTLSYLDSVSLMSGTLESLADDVSSMGSD 293
Query: 62 RRNSGSSL-------------VSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLL 108
+G +L S S SS + + W + + W++W R+ + +
Sbjct: 294 SEINGLALRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKV 353
Query: 109 KELIRKGIPHHFRAIVWQLLCSATDMPVKN--QYSELLKMSSPCEKL--IRRDIARTYPE 164
K RKGIP RA WQ L ++ ++ +N ++ EL + + L I +D+ R +P
Sbjct: 354 KLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPF 413
Query: 165 HEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQ 224
HE F + GQ+ L+ ++KAY++ + GYCQ A + +LLM MP E+AF V++
Sbjct: 414 HEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICD 473
Query: 225 EYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTF 284
+Y L + + + L F +L+ P + H R Q +Y + WF+ +F T
Sbjct: 474 KY-LPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTL 532
Query: 285 PLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQL-DMEGMSQYFQ--RVIPHQFDS 341
P RV+D+F EG++I+FRV L LL+ + +L +GM + + R +P Q
Sbjct: 533 PWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQ--- 589
Query: 342 CPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIK 382
C + L ++V P +E+E AA K E + E++
Sbjct: 590 CMQEDFL-VHEVTNLPVTEALIERENAAQLKKWRETRGELQ 629
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 141 bits (356), Expect = 2e-33
Identities = 93/284 (32%), Positives = 139/284 (48%), Gaps = 12/284 (4%)
Query: 40 KLEEQNRLLEADSKSMRSMNGSRRNSGSSLVSSSSASSNLSHLEEDTW----ILWGRIAN 95
+L++ + L +DS+ + R+ + SSA H D + W + +
Sbjct: 14 ELQDDSSSLGSDSE-LSGPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTS 72
Query: 96 EWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ---YSELLKMSSPCE- 151
WE+ R+ K +K RKGIP RA W LLC A + KN Y EL + +
Sbjct: 73 HWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGA-HVCQKNSPGTYQELAEAPGDPQW 131
Query: 152 -KLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQM 210
+ I RD+ R +P HE F GQ+ L V+KAY+L E GYCQ + +LLM +
Sbjct: 132 METIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHL 191
Query: 211 PEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSM 270
P EEAF V++ + Y L + P M + L F +L+ LP ++ H + +
Sbjct: 192 PPEEAFWCLVQICEVY-LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLL 250
Query: 271 YASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQV 314
Y WFL LF + P P RV+D F+ EG ++FRVGL L+++
Sbjct: 251 YLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRL 294
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 135 bits (341), Expect = 1e-31
Identities = 96/305 (31%), Positives = 142/305 (46%), Gaps = 14/305 (4%)
Query: 14 EALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNGSRRNSGSSLVSSS 73
E+LS S + + DEL L E N E + GS+ G+
Sbjct: 17 ESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGAL----E 72
Query: 74 SASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATD 133
+ E W+ + N W++W +K K ++ +KGIP R WQ L
Sbjct: 73 EVPLEVLRQRESKWL---DMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKV 129
Query: 134 MPVKN--QYSELLKMSSPCEK---LIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSL 188
+N ++ EL MS K +I RD+ R +P HE F + GQ+ LF V+KAY+L
Sbjct: 130 KLQQNPGKFDEL-DMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTL 188
Query: 189 VDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEY 248
E GYCQ A I +LLM MP E+AF V++ ++Y L + + + L
Sbjct: 189 YRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKY-LPGYYSEKLEAIQLDGEILFS 247
Query: 249 MLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVG 308
+LQ+ P + H Q +Y + WF+ F T P RV+D+F EG++I+FRVG
Sbjct: 248 LLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVG 307
Query: 309 LALLQ 313
L LL+
Sbjct: 308 LVLLK 312
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 124 bits (311), Expect = 3e-28
Identities = 84/317 (26%), Positives = 160/317 (50%), Gaps = 23/317 (7%)
Query: 108 LKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ---------YSELLKMSSPCEKLIRRDI 158
LK LIR GIPH R+ VW+ K+ + L+ +P K I D+
Sbjct: 655 LKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDL 714
Query: 159 ARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCV 218
RT P ++ + S G + L NV+ A+S + ++GYCQG +V + L+ + +E+AF
Sbjct: 715 LRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWC 774
Query: 219 FVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLT 278
V +++ + R+ + ++ + F ++ E+LP L+ HF ++ +WFL
Sbjct: 775 LVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLV 834
Query: 279 LFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMS-----QYFQR 333
+F+ + + +++D F+YEG +++FR LAL + + E+++L + MS +YF R
Sbjct: 835 VFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKL-QDSMSIFKYLRYFTR 893
Query: 334 VIPHQFDSCPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQ 393
I D+ KL+ ++ NP ++++ A K E E++ +R + L++
Sbjct: 894 TI---LDA--RKLISISFG-DLNPFPLRQIRNRRAYHLEKVRLELTELEAIRED--FLRE 945
Query: 394 RIETLEKGQVTRAQEAE 410
R + +KG++ +E +
Sbjct: 946 RDTSPDKGELVSDEEED 962
>gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1120
Score = 122 bits (305), Expect = 2e-27
Identities = 107/370 (28%), Positives = 175/370 (47%), Gaps = 47/370 (12%)
Query: 82 LEEDTW-ILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ- 139
++E +W IL+ +R +K + +L+ +GIP R +W L A + N
Sbjct: 456 MKEQSWKILFAECGRGVSMFRTKKTR---DLVVRGIPETLRGELWMLFSGAVNDMATNPD 512
Query: 140 -YSELLKMSSPCEKL----IRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVG 194
Y+E+++ S L I RD+ R+ PEH F Q G L V+ AY+ + ++G
Sbjct: 513 YYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAF--QSDTGISALRRVLTAYAYRNPKIG 570
Query: 195 YCQGSAFIVGLLLMQMPEEEAFCVFV----RLMQEYRLRELFKPSMAELGLCIYQ--FEY 248
YCQ + +LL+ EEEAF + V R++ +Y R + +G + Q FE
Sbjct: 571 YCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRI-------IGALVDQAVFEE 623
Query: 249 MLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVG 308
++++ LP L H +F +S+ + SWFLTLF++ P+ A V D F Y+G++ + ++G
Sbjct: 624 LIRDHLPQLTEHMTDMTFFSSV-SLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLG 682
Query: 309 LALLQVNQAELMQLD-----MEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRL 363
LA+L N +L+ + ++++F V DS V + V R+
Sbjct: 683 LAILDYNLDKLLTCKDDAEAVTALNRFFDNVT--NKDSPLPSNVQQGSNVSDEKTSHTRV 740
Query: 364 EKEYAAMKSKEMEEQI---EIKRLRTENRL-LKQRIETLEKGQVTRA---------QEAE 410
+ +S E I +I +R NRL + Q +E K V R QE +
Sbjct: 741 DITDLIRESNEKYGNIRYEDIHSMRCRNRLYVIQTLEETTKQNVLRVVSQDVKLSLQELD 800
Query: 411 ENYVI-KREL 419
E YVI K+EL
Sbjct: 801 ELYVIFKKEL 810
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 118 bits (295), Expect = 2e-26
Identities = 69/242 (28%), Positives = 125/242 (51%), Gaps = 15/242 (6%)
Query: 108 LKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ---------YSELLKMSSPCEKLIRRDI 158
LK LIR GIPH R+ VW+ K+ + L+ +P K I D+
Sbjct: 655 LKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDL 714
Query: 159 ARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCV 218
RT P ++ + S G + L NV+ A+S + ++GYCQG +V + L+ + +E+AF
Sbjct: 715 LRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWC 774
Query: 219 FVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLT 278
V +++ + R+ + ++ + F ++ E+LP L+ HF ++ +WFL
Sbjct: 775 LVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLV 834
Query: 279 LFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMS-----QYFQR 333
+F+ + + +++D F+YEG +++FR LAL + + E+++L + MS +YF R
Sbjct: 835 VFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKL-QDSMSIFKYLRYFTR 893
Query: 334 VI 335
I
Sbjct: 894 TI 895
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 116 bits (290), Expect = 9e-26
Identities = 88/328 (26%), Positives = 149/328 (45%), Gaps = 33/328 (10%)
Query: 19 PTCSPTSDSENLSPD--ELELLAKLEEQNRLLEA-----DSKSMRSMNGSRRNSGSSLVS 71
P C P S L+P E+LAK ++ E D R GSSL++
Sbjct: 7 PACGPFSA---LTPSIWPQEILAKYTQKEESAEQPEFYYDEFGFRVYKEEGDEPGSSLLA 63
Query: 72 SS------------SASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHH 119
+S A +H + + W +IA R EKL + L+ GIPH
Sbjct: 64 NSPLMEDAPQRLRWQAHLEFTHNHDVGDLTWDKIAVSLP----RSEKL-RSLVLAGIPHG 118
Query: 120 FRAIVWQLLCSATDMPVKNQ--YSELLKMSSPCE----KLIRRDIARTYPEHEFFKGQDS 173
R +W L A ++ Y E++K SS E K I +D+ RT P + F S
Sbjct: 119 MRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGS 178
Query: 174 LGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFK 233
+G L V++A + + E+GYCQG+ + LL+ + EE+AF + ++++ F
Sbjct: 179 IGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFS 238
Query: 234 PSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVF 293
++ + +++ + LP L+ + S+ WFLT F + + + R++
Sbjct: 239 TTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIW 298
Query: 294 DIFMYEGLEIVFRVGLALLQVNQAELMQ 321
D+F YEG ++F++ L +L + + EL+Q
Sbjct: 299 DLFFYEGSRVLFQLTLGMLHLKEEELIQ 326
>gi|45597177 TBC1 domain family, member 9B (with GRAM domain)
isoform b [Homo sapiens]
Length = 1233
Score = 115 bits (288), Expect = 2e-25
Identities = 99/334 (29%), Positives = 160/334 (47%), Gaps = 36/334 (10%)
Query: 109 KELIRKGIPHHFRAIVWQLLCSATDMPVKNQ--YSELLKMSSPCEKL----IRRDIARTY 162
+ L+ KGIP R +W L A + V + Y+EL++ S+ L I RD+ R+
Sbjct: 502 RALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSM 561
Query: 163 PEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRL 222
PEH F Q+ LG L V+ AY+ + +GYCQ + +LL+ EEEAF + V L
Sbjct: 562 PEHPAF--QNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVAL 619
Query: 223 MQEYRLRELFKPSMAELGLCIYQ--FEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLF 280
E L + + + +G + Q FE + ++ LP L+ + +S+ + SWFLTLF
Sbjct: 620 C-ERMLPDYYNTRV--VGALVDQGIFEELTRDFLPQLSEKMQDLGVISSI-SLSWFLTLF 675
Query: 281 LTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEG-----MSQYFQRVI 335
L+ P A + D F YEG++++ +V LA+L N +L+ EG + +Y V+
Sbjct: 676 LSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVV 735
Query: 336 PHQFDSCPDKLVLKAYQVKYNPKK----MKRLEKEYAAMKSKEMEEQIEIKRLRTENRL- 390
Q S P + +P + L+ Y S E +I+++R + RL
Sbjct: 736 NKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAE---DIEQMRFKQRLK 792
Query: 391 LKQRIETLEKGQVTRA---------QEAEENYVI 415
+ Q +E K V RA +E E+ Y++
Sbjct: 793 VIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMV 826
>gi|45597175 TBC1 domain family, member 9B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1250
Score = 115 bits (288), Expect = 2e-25
Identities = 99/334 (29%), Positives = 160/334 (47%), Gaps = 36/334 (10%)
Query: 109 KELIRKGIPHHFRAIVWQLLCSATDMPVKNQ--YSELLKMSSPCEKL----IRRDIARTY 162
+ L+ KGIP R +W L A + V + Y+EL++ S+ L I RD+ R+
Sbjct: 502 RALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSM 561
Query: 163 PEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRL 222
PEH F Q+ LG L V+ AY+ + +GYCQ + +LL+ EEEAF + V L
Sbjct: 562 PEHPAF--QNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVAL 619
Query: 223 MQEYRLRELFKPSMAELGLCIYQ--FEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLF 280
E L + + + +G + Q FE + ++ LP L+ + +S+ + SWFLTLF
Sbjct: 620 C-ERMLPDYYNTRV--VGALVDQGIFEELTRDFLPQLSEKMQDLGVISSI-SLSWFLTLF 675
Query: 281 LTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEG-----MSQYFQRVI 335
L+ P A + D F YEG++++ +V LA+L N +L+ EG + +Y V+
Sbjct: 676 LSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVV 735
Query: 336 PHQFDSCPDKLVLKAYQVKYNPKK----MKRLEKEYAAMKSKEMEEQIEIKRLRTENRL- 390
Q S P + +P + L+ Y S E +I+++R + RL
Sbjct: 736 NKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAE---DIEQMRFKQRLK 792
Query: 391 LKQRIETLEKGQVTRA---------QEAEENYVI 415
+ Q +E K V RA +E E+ Y++
Sbjct: 793 VIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMV 826
>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
Length = 775
Score = 111 bits (278), Expect = 2e-24
Identities = 95/387 (24%), Positives = 165/387 (42%), Gaps = 45/387 (11%)
Query: 14 EALSAPTCSPTSDSENLSPDELELLAK--LEEQNRLLEADSKSMRSMNGSRRNSGSSLVS 71
EA + TC P S E E L+ L ++R +KS+ R+ +
Sbjct: 368 EARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEALRHRQEYDEMVAE 427
Query: 72 SSSASSNLSHLEE--------------DTWILW-GRIANEWEEWRRRKEKLLKELIRKGI 116
+ +H + ++W I WE R + ++EL +G+
Sbjct: 428 AKKREIKEAHKRKRIMKERFKQEENIASAMVIWINEILPNWEVMRSTRR--VRELWWQGL 485
Query: 117 PHHFRAIVWQL-----------LCSATDMPVKNQYSELLKMSSPCE-------------K 152
P R VW L L K ++ + SS + +
Sbjct: 486 PPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADREASLE 545
Query: 153 LIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPE 212
LI+ DI+RT+P F+ + +VL +++ AY+ +VGY QG +FI +L++ + E
Sbjct: 546 LIKLDISRTFPSLYIFQ-KGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEE 604
Query: 213 EEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYA 272
+AF F L+ + F+ + + FE +E L L HF+S S +Y
Sbjct: 605 ADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYL 664
Query: 273 SSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQ 332
W TL+ + PL +A RV+D+F +G E +FR GL +L++ + L+Q+D ++Q+
Sbjct: 665 IDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLT 724
Query: 333 RVIPHQFDSCPDKLVLKAYQVKYNPKK 359
+ +P S + A Q++ + KK
Sbjct: 725 K-LPEDITSEKLFSCIAAIQMQNSTKK 750
>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
Length = 1140
Score = 111 bits (277), Expect = 3e-24
Identities = 95/331 (28%), Positives = 156/331 (47%), Gaps = 24/331 (7%)
Query: 9 DSSSQEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNGSRRNSGSS 68
D+S+ + +++ TS + +LE+++ + E++ + M+ +
Sbjct: 403 DTSADDDMASLVFHSTSMCSDHRFGDLEMMSSQNSE----ESEKEKSPLMHPDALVTAFQ 458
Query: 69 LVSSSSASSNLSHLEEDTWILWGRIANEWEEWRR-----RKEKLLKELIRKGIPHHFRAI 123
S S S +S E+ LW + + E+ R R EK+ K L+ GIP R
Sbjct: 459 QSGSQSPDSRMSR-EQIKISLWN---DHFVEYGRTVCMFRTEKIRK-LVAMGIPESLRGR 513
Query: 124 VWQLLCSA-TDMPVKNQY-----SELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQE 177
+W L A TD+ Y E L + I RD+ R+ PEH F Q+ G
Sbjct: 514 LWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVTEEIERDLHRSLPEHPAF--QNETGIA 571
Query: 178 VLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMA 237
L V+ AY+ + ++GYCQ + +LL+ EEEAF + V + E L + F +
Sbjct: 572 ALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEEEAFWLLVAVC-ERMLPDYFNHRVI 630
Query: 238 ELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFM 297
+ FE +++ LP+L H S S+ + SWFLTLFL+ PL A V D F
Sbjct: 631 GAQVDQSVFEELIKGHLPELAEHMNDLSALASV-SLSWFLTLFLSIMPLESAVNVVDCFF 689
Query: 298 YEGLEIVFRVGLALLQVNQAELMQLDMEGMS 328
Y+G++ +F++GLA+L+ N +L +G +
Sbjct: 690 YDGIKAIFQLGLAVLEANAEDLCSSKDDGQA 720
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 108 bits (269), Expect = 3e-23
Identities = 81/251 (32%), Positives = 126/251 (50%), Gaps = 18/251 (7%)
Query: 103 RKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ--YSELLKMSSPCEKL----IRR 156
R EK +EL+ KGIP R +W LL A + + Y +L++ S L I R
Sbjct: 504 RTEKT-RELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIER 562
Query: 157 DIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAF 216
D+ R+ PEH F Q+ +G L V+ AY+ + +GYCQ + +LL+ EEEAF
Sbjct: 563 DLHRSLPEHPAF--QNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAF 620
Query: 217 CVFVRLMQEYRLRELFKPSMAELGLCIYQ--FEYMLQEQLPDLNTHFRSQSFHTSMYASS 274
+ V L E L + + + +G + Q FE + ++ +P L + S + S
Sbjct: 621 WLLVALC-ERMLPDYYNTRV--VGALVDQGVFEELARDYVPQLYDCMQDLGV-ISTISLS 676
Query: 275 WFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRV 334
WFLTLFL+ P A V D F YEG++++F++ LA+L N +L+ +G + V
Sbjct: 677 WFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEA---MTV 733
Query: 335 IPHQFDSCPDK 345
+ DS +K
Sbjct: 734 LGRYLDSVTNK 744
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 105 bits (263), Expect = 1e-22
Identities = 70/224 (31%), Positives = 117/224 (52%), Gaps = 7/224 (3%)
Query: 104 KEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ--YSELLK--MSSPCEKLIRRDIA 159
+ + +K +RKG+P RA VW +L A +N Y +LL+ + E IR D+
Sbjct: 57 RSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLN 116
Query: 160 RTYPEH-EFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG-LLLMQMPEEEAFC 217
RT+P++ +F K D Q L+NV+ AY ++ VGYCQG FI G L+L+ EEE+F
Sbjct: 117 RTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFW 176
Query: 218 VFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFL 277
+ L+ L + + P+M L +++ +LP + ++ S WF+
Sbjct: 177 LLDALVGRI-LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFI 235
Query: 278 TLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQ 321
LF+ P+ R++D EG +I+FRV L L++ +Q +++
Sbjct: 236 CLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILE 279
>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
Length = 413
Score = 103 bits (256), Expect = 8e-22
Identities = 84/316 (26%), Positives = 142/316 (44%), Gaps = 41/316 (12%)
Query: 93 IANEWEE-WRRRKEKLLKELIRKGIPHHFRAIVWQL--------------LCSATDMPVK 137
I WE W RK +++L +GIP R VW L +C A K
Sbjct: 101 ILPNWETMWCSRK---VRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLAR---AK 154
Query: 138 NQYSELLKMSSPCE---------------KLIRRDIARTYPEHEFFKGQDSLGQEVLFNV 182
++ L S E +LI+ DI+RT+P F+ Q ++L ++
Sbjct: 155 ERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQ-QGGPYHDMLHSI 213
Query: 183 MKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLC 242
+ AY+ +VGY QG +FI +L++ + +AF F L+ + F+ +
Sbjct: 214 LGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTY 273
Query: 243 IYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLE 302
FE +E LP L HF+ + +Y W TL+ + PL +A R++D+F +G E
Sbjct: 274 FAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEE 333
Query: 303 IVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKR 362
+FR L +L++ + L ++D M+Q+ R +P D ++L ++ + K
Sbjct: 334 FLFRTALGILKLFEDILTKMDFIHMAQFLTR-LPE--DLPAEELFASIATIQMQSRNKKW 390
Query: 363 LEKEYAAMK-SKEMEE 377
+ A K S+EME+
Sbjct: 391 AQVLTALQKDSREMEK 406
>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 103 bits (256), Expect = 8e-22
Identities = 84/316 (26%), Positives = 142/316 (44%), Gaps = 41/316 (12%)
Query: 93 IANEWEE-WRRRKEKLLKELIRKGIPHHFRAIVWQL--------------LCSATDMPVK 137
I WE W RK +++L +GIP R VW L +C A K
Sbjct: 381 ILPNWETMWCSRK---VRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLAR---AK 434
Query: 138 NQYSELLKMSSPCE---------------KLIRRDIARTYPEHEFFKGQDSLGQEVLFNV 182
++ L S E +LI+ DI+RT+P F+ Q ++L ++
Sbjct: 435 ERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQ-QGGPYHDMLHSI 493
Query: 183 MKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLC 242
+ AY+ +VGY QG +FI +L++ + +AF F L+ + F+ +
Sbjct: 494 LGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTY 553
Query: 243 IYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLE 302
FE +E LP L HF+ + +Y W TL+ + PL +A R++D+F +G E
Sbjct: 554 FAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEE 613
Query: 303 IVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKR 362
+FR L +L++ + L ++D M+Q+ R +P D ++L ++ + K
Sbjct: 614 FLFRTALGILKLFEDILTKMDFIHMAQFLTR-LPE--DLPAEELFASIATIQMQSRNKKW 670
Query: 363 LEKEYAAMK-SKEMEE 377
+ A K S+EME+
Sbjct: 671 AQVLTALQKDSREMEK 686
>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 103 bits (256), Expect = 8e-22
Identities = 84/316 (26%), Positives = 142/316 (44%), Gaps = 41/316 (12%)
Query: 93 IANEWEE-WRRRKEKLLKELIRKGIPHHFRAIVWQL--------------LCSATDMPVK 137
I WE W RK +++L +GIP R VW L +C A K
Sbjct: 381 ILPNWETMWCSRK---VRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLAR---AK 434
Query: 138 NQYSELLKMSSPCE---------------KLIRRDIARTYPEHEFFKGQDSLGQEVLFNV 182
++ L S E +LI+ DI+RT+P F+ Q ++L ++
Sbjct: 435 ERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQ-QGGPYHDMLHSI 493
Query: 183 MKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLC 242
+ AY+ +VGY QG +FI +L++ + +AF F L+ + F+ +
Sbjct: 494 LGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTY 553
Query: 243 IYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLE 302
FE +E LP L HF+ + +Y W TL+ + PL +A R++D+F +G E
Sbjct: 554 FAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEE 613
Query: 303 IVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKR 362
+FR L +L++ + L ++D M+Q+ R +P D ++L ++ + K
Sbjct: 614 FLFRTALGILKLFEDILTKMDFIHMAQFLTR-LPE--DLPAEELFASIATIQMQSRNKKW 670
Query: 363 LEKEYAAMK-SKEMEE 377
+ A K S+EME+
Sbjct: 671 AQVLTALQKDSREMEK 686
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 92.8 bits (229), Expect = 1e-18
Identities = 75/294 (25%), Positives = 134/294 (45%), Gaps = 16/294 (5%)
Query: 90 WGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ-----YSELL 144
W + EWE ++ + L + + KGIP + R VW +L + ++ +KN E
Sbjct: 77 WMEMLGEWETYKHSSK--LIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMKERG 134
Query: 145 KMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG 204
K SS I D+ T H FF+ + Q LF ++ AYS + EVGYC+ + I
Sbjct: 135 KRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRELFYILLAYSEYNPEVGYCRDLSHITA 194
Query: 205 LLLMQMPEEEAFCVFVRLM--QEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFR 262
L L+ +PEE+AF V+L+ + + L P+ + Q E+++ + P H
Sbjct: 195 LFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQEHVVPKSQPKTMWHQD 254
Query: 263 SQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQL 322
+ + L + L + R++D+++ EG +++ + L+V Q LM+
Sbjct: 255 KEGLCGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKT 314
Query: 323 DMEGMSQYFQRVIPHQFD--SCPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKE 374
G+ + R+ FD + D VLK ++ + KK+ R + + +E
Sbjct: 315 SRCGL---WARLRNQFFDTWAMNDDTVLK--HLRASTKKLTRKQGDLPPPAKRE 363
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 89.4 bits (220), Expect = 1e-17
Identities = 96/390 (24%), Positives = 165/390 (42%), Gaps = 50/390 (12%)
Query: 13 QEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSK--SMRSMNGSRRNSGSSLV 70
QEAL +SDS LSP ++K +E L D + ++ + + +
Sbjct: 537 QEALQWEAGEASSDSIELSP-----ISKYDEYGFLTVPDYEVEDLKLL--------AKIQ 583
Query: 71 SSSSASSNLSHLE------EDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIV 124
+ S S +L LE + W G + E LK+L+R G+P R V
Sbjct: 584 ALESRSHHLLGLEAVDRPLRERWAALGDLVPSAE---------LKQLLRAGVPREHRPRV 634
Query: 125 WQLLCS--ATDMPVKNQYSELLKMSS----PCEKLIRRDIARTYPEHEFFKGQDSLGQEV 178
W+ L + Y ELL P + I D+ RT+P ++ F S +
Sbjct: 635 WRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDK 694
Query: 179 LFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEE-AFCVFVRLMQEYRLRELFKPSMA 237
L V+ A+S + +GYCQG + + L+ + EEE AF V +++ + + ++
Sbjct: 695 LRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLT 754
Query: 238 ELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFM 297
+ + +L E+LP L H S+ +WFL +F + + RV+D F+
Sbjct: 755 ASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFL 814
Query: 298 YEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNP 357
YEG + N+ E+++L G+ Y + S KL+ A+ NP
Sbjct: 815 YEG-----------TKYNEKEILRL-QNGLEIYQYLRFFTKTISNSRKLMNIAFN-DMNP 861
Query: 358 KKMKRLEKEYAAMKSKEMEEQIEIKRLRTE 387
+MK+L + + + E E+++L+ E
Sbjct: 862 FRMKQLRQLRMVHRERLEAELRELEQLKAE 891
>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
Length = 549
Score = 85.1 bits (209), Expect = 2e-16
Identities = 58/237 (24%), Positives = 111/237 (46%), Gaps = 9/237 (3%)
Query: 90 WGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ-----YSELL 144
W + +WE+++ ++ L + KG+P + R +W +L + +M +KN E
Sbjct: 78 WVDMLGDWEKYKSSRK--LIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKG 135
Query: 145 KMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG 204
K SS + I RDI+ T +H FF+ + Q L +++ AY + EVGYC+ + I
Sbjct: 136 KRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAA 195
Query: 205 LLLMQMPEEEAFCVFVRLM--QEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFR 262
L L+ +PEE+AF V+L+ + + L+ P+ + Q E+++ P H
Sbjct: 196 LFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQD 255
Query: 263 SQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAEL 319
+ + + + L + R++D+++ EG + + + +V Q L
Sbjct: 256 KKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRL 312
>gi|157502205 TBC1 domain family, member 3G [Homo sapiens]
Length = 549
Score = 85.1 bits (209), Expect = 2e-16
Identities = 58/237 (24%), Positives = 111/237 (46%), Gaps = 9/237 (3%)
Query: 90 WGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ-----YSELL 144
W + +WE+++ ++ L + KG+P + R +W +L + +M +KN E
Sbjct: 78 WVDMLGDWEKYKSSRK--LIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKG 135
Query: 145 KMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG 204
K SS + I RDI+ T +H FF+ + Q L +++ AY + EVGYC+ + I
Sbjct: 136 KRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAA 195
Query: 205 LLLMQMPEEEAFCVFVRLM--QEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFR 262
L L+ +PEE+AF V+L+ + + L+ P+ + Q E+++ P H
Sbjct: 196 LFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQD 255
Query: 263 SQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAEL 319
+ + + + L + R++D+++ EG + + + +V Q L
Sbjct: 256 KKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRL 312
>gi|14149985 TBC1 domain family, member 3F [Homo sapiens]
Length = 549
Score = 84.7 bits (208), Expect = 3e-16
Identities = 57/237 (24%), Positives = 111/237 (46%), Gaps = 9/237 (3%)
Query: 90 WGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ-----YSELL 144
W + +WE+++ ++ L + KG+P + R +W +L + +M +KN E
Sbjct: 78 WVDMLGDWEKYKSSRK--LIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKG 135
Query: 145 KMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG 204
K SS + I RD++ T +H FF+ + Q L +++ AY + EVGYC+ + I
Sbjct: 136 KKSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAA 195
Query: 205 LLLMQMPEEEAFCVFVRLM--QEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFR 262
L L+ +PEE+AF V+L+ + + L+ P+ + Q E+++ P H
Sbjct: 196 LFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQD 255
Query: 263 SQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAEL 319
+ + + + L + R++D+++ EG + + + +V Q L
Sbjct: 256 KKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRL 312
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.359
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,137,382
Number of Sequences: 37866
Number of extensions: 1266007
Number of successful extensions: 12308
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 245
Number of HSP's successfully gapped in prelim test: 894
Number of HSP's that attempted gapping in prelim test: 7145
Number of HSP's gapped (non-prelim): 3619
length of query: 794
length of database: 18,247,518
effective HSP length: 110
effective length of query: 684
effective length of database: 14,082,258
effective search space: 9632264472
effective search space used: 9632264472
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.