Guide to the Human Genome
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Search of human proteins with 215598824

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform
2 [Homo sapiens]
         (474 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2...   972   0.0  
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1...   953   0.0  
gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3...   642   0.0  
gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo sap...   279   3e-75
gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [H...   221   1e-57
gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isof...   174   2e-43
gi|22208964 ankyrin repeat and SOCS box-containing protein 4 iso...   141   1e-33
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       126   4e-29
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        126   4e-29
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        126   4e-29
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       122   5e-28
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        122   5e-28
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        122   5e-28
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        122   5e-28
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        122   5e-28
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        120   3e-27
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   115   7e-26
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   110   4e-24
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   110   4e-24
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   110   4e-24
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   109   5e-24
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          108   8e-24
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   107   3e-23
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   105   9e-23
gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Ho...   105   1e-22
gi|121582655 ankyrin repeat domain 35 [Homo sapiens]                  104   2e-22
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   103   3e-22
gi|18079216 CASK interacting protein 1 [Homo sapiens]                 103   3e-22
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is...   103   3e-22
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is...   103   3e-22

>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
           [Homo sapiens]
          Length = 474

 Score =  972 bits (2512), Expect = 0.0
 Identities = 474/474 (100%), Positives = 474/474 (100%)

Query: 1   MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE 60
           MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE
Sbjct: 1   MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE 60

Query: 61  PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA 120
           PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA
Sbjct: 61  PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA 120

Query: 121 DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL 180
           DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL
Sbjct: 121 DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL 180

Query: 181 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240
           LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE
Sbjct: 181 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240

Query: 241 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 300
           CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA
Sbjct: 241 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 300

Query: 301 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS 360
           CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS
Sbjct: 301 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS 360

Query: 361 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKKHQRFYS 420
           CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKKHQRFYS
Sbjct: 361 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKKHQRFYS 420

Query: 421 SLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 474
           SLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY
Sbjct: 421 SLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 474


>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
           [Homo sapiens]
          Length = 512

 Score =  953 bits (2463), Expect = 0.0
 Identities = 474/512 (92%), Positives = 474/512 (92%), Gaps = 38/512 (7%)

Query: 1   MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE 60
           MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE
Sbjct: 1   MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE 60

Query: 61  PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA 120
           PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA
Sbjct: 61  PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA 120

Query: 121 DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL 180
           DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL
Sbjct: 121 DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL 180

Query: 181 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240
           LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE
Sbjct: 181 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240

Query: 241 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 300
           CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA
Sbjct: 241 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 300

Query: 301 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS 360
           CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS
Sbjct: 301 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS 360

Query: 361 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPK------- 413
           CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPK       
Sbjct: 361 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWST 420

Query: 414 -------------------------------KHQRFYSSLFALVRQPRSLQHLSRCALRS 442
                                          KHQRFYSSLFALVRQPRSLQHLSRCALRS
Sbjct: 421 CPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRS 480

Query: 443 HLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 474
           HLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY
Sbjct: 481 HLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 512


>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
           [Homo sapiens]
          Length = 452

 Score =  642 bits (1655), Expect = 0.0
 Identities = 332/412 (80%), Positives = 340/412 (82%), Gaps = 45/412 (10%)

Query: 101 LAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEE 160
           +A   A+  GD+  +  +         P S  D     R  + R++     LWSLTYEEE
Sbjct: 48  MALQNALYTGDLARLQELFP-------PHSTADLLLESRAAEPRWSSHQRGLWSLTYEEE 100

Query: 161 LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPN 220
           LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPN
Sbjct: 101 LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPN 160

Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 280
           IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL
Sbjct: 161 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 220

Query: 281 RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 340
           RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ
Sbjct: 221 RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 280

Query: 341 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN 400
           RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN
Sbjct: 281 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN 340

Query: 401 HGAVRVWPGALPK--------------------------------------KHQRFYSSL 422
           HGAVRVWPGALPK                                      KHQRFYSSL
Sbjct: 341 HGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSL 400

Query: 423 FALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 474
           FALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY
Sbjct: 401 FALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 452


>gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo
           sapiens]
          Length = 466

 Score =  279 bits (714), Expect = 3e-75
 Identities = 164/361 (45%), Positives = 198/361 (54%), Gaps = 43/361 (11%)

Query: 152 LWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHV 211
           LW+L Y+ ELTTPL +AA+ GHT  +R LL R A PD++PGGR ALHEAC  GHTACV +
Sbjct: 111 LWTLEYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRL 170

Query: 212 LLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLG 271
           LL   ADP++   +G  PLHLCR   +L CA+ LL  GA V        +TPLHVAA+ G
Sbjct: 171 LLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRG 230

Query: 272 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331
             E A L L RGA  DARN  G T L AAC               RCL+LC+LLL  GA+
Sbjct: 231 LDEHARLYLGRGAHVDARNGRGETALSAAC-----GAARRPDEHGRCLRLCALLLRRGAE 285

Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391
           ADA D+D++ PLH AC     ++  LLL  G  A  +DYGG +PL   LQ  + AL  SP
Sbjct: 286 ADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASP 345

Query: 392 EHVVRALLNHGAVRVWPGALPK-------------------------------------- 413
           +  V+ALLNHG+  VWP A PK                                      
Sbjct: 346 QRTVQALLNHGSPTVWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQ 405

Query: 414 KHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVL 473
            H+ FY SLFAL   PR LQHL RCALR          +P LPLP  L  YL L+ +GVL
Sbjct: 406 MHKPFYQSLFALALTPRCLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVL 465

Query: 474 Y 474
           +
Sbjct: 466 H 466


>gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [Homo
           sapiens]
          Length = 453

 Score =  221 bits (562), Expect = 1e-57
 Identities = 139/355 (39%), Positives = 180/355 (50%), Gaps = 39/355 (10%)

Query: 153 WSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVL 212
           W LT + + T PL +A +RG+T+  R L+R+ A  D+  GGR ALHEACA     CV +L
Sbjct: 103 WVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLL 162

Query: 213 LVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGH 272
           L  GA  N+  ++G  PLHLC  P +L+CA+LLL  GA V+  + E +ETPLHVAA  G 
Sbjct: 163 LTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGL 222

Query: 273 VELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADA 332
            +   L L  GA    R ++G T L  AC     +  +   +  R       LL AGADA
Sbjct: 223 EQHVALYLEHGADVGLRTSQGETALNTAC-----AGAEGPGSCRRHQAAARRLLEAGADA 277

Query: 333 DAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPE 392
            AA + +  PLH AC  G   + ELLL  G  A   +  GHTP+ CALQ    +    PE
Sbjct: 278 RAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPE 337

Query: 393 HVVRALLNHGAVRVWPGALP----------------------------------KKHQRF 418
            +  ALL++GA  V P  L                                   K+H+ F
Sbjct: 338 VLFAALLDYGAQPVRPEMLKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAF 397

Query: 419 YSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVL 473
           YSS   +V QPR LQHL+R A+R+ L     Q   RLPLPP L  YL L  EG +
Sbjct: 398 YSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLLLRVEGCI 452



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 46/126 (36%), Positives = 57/126 (45%), Gaps = 9/126 (7%)

Query: 137 PERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRT 195
           PE  +  +  + A    +L   E   TPLHVAA+RG  + + L L   A        G T
Sbjct: 186 PESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGET 245

Query: 196 ALHEACAAG--------HTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR 247
           AL+ ACA          H A    LL AGAD   A +    PLH     G    AELLLR
Sbjct: 246 ALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLR 305

Query: 248 FGARVD 253
           +GAR +
Sbjct: 306 YGARAE 311


>gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isoform
           a [Homo sapiens]
          Length = 426

 Score =  174 bits (440), Expect = 2e-43
 Identities = 135/430 (31%), Positives = 191/430 (44%), Gaps = 53/430 (12%)

Query: 85  KSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFR 144
           KSG   +V R        F +A+ + D G +  IL      +  D+VF+  D        
Sbjct: 10  KSGAAKLVKRN-------FLEALKSNDFGKLKAILIQRQIDV--DTVFEVEDENMV--LA 58

Query: 145 FNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAG 204
              +   L S   +    T LH++   GH E L +LL   A  +  P G+T LH AC   
Sbjct: 59  SYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMA 118

Query: 205 HTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR-SEEEEETP 263
           +  CV +L   GA  N     G   LH C  P ++ CA+ L+  GA V+ + + ++EETP
Sbjct: 119 NVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETP 178

Query: 264 LHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCS 323
           LH AA  G  EL    +  GA  D+ NA   TPL  A         + E +T   L +C 
Sbjct: 179 LHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAA-YWALRFKEQEYSTEHHL-VCR 236

Query: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 383
           +LL   A+ +A D D + PLH A       ++ ++L  G  AN MD  G   +   L+  
Sbjct: 237 MLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVT 296

Query: 384 AAALAQSPEHVVRALLNHGAVRV----------------------------------WPG 409
           +   A  PE   + LLNHGA R+                                  W  
Sbjct: 297 SVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRR 356

Query: 410 ALP----KKHQRFYSSLFAL-VRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRY 464
           A+P    +K+  FY SLF +    PR+L HLSRCA+R  L     +A+P L LP  L +Y
Sbjct: 357 AIPDDDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKY 416

Query: 465 LQLDFEGVLY 474
           L L+ EG++Y
Sbjct: 417 LLLEPEGIIY 426


>gi|22208964 ankyrin repeat and SOCS box-containing protein 4
           isoform b [Homo sapiens]
          Length = 349

 Score =  141 bits (356), Expect = 1e-33
 Identities = 104/325 (32%), Positives = 149/325 (45%), Gaps = 14/325 (4%)

Query: 85  KSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFR 144
           KSG   +V R        F +A+ + D G +  IL      +  D+VF+  D        
Sbjct: 10  KSGAAKLVKRN-------FLEALKSNDFGKLKAILIQRQIDV--DTVFEVEDENMV--LA 58

Query: 145 FNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAG 204
              +   L S   +    T LH++   GH E L +LL   A  +  P G+T LH AC   
Sbjct: 59  SYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMA 118

Query: 205 HTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR-SEEEEETP 263
           +  CV +L   GA  N     G   LH C  P ++ CA+ L+  GA V+ + + ++EETP
Sbjct: 119 NVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETP 178

Query: 264 LHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCS 323
           LH AA  G  EL    +  GA  D+ NA   TPL  A         + E +T   L +C 
Sbjct: 179 LHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAA-YWALRFKEQEYSTEHHL-VCR 236

Query: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 383
           +LL   A+ +A D D + PLH A       ++ ++L  G  AN MD  G   +   L+  
Sbjct: 237 MLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVT 296

Query: 384 AAALAQSPEHVVRALLNHGAVRVWP 408
           +   A  PE   + LLNHGA R++P
Sbjct: 297 SVRPAAQPEICYQLLLNHGAARIYP 321


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  126 bits (317), Expect = 4e-29
 Identities = 89/245 (36%), Positives = 123/245 (50%), Gaps = 22/245 (8%)

Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGAD 218
           E  TPLH+A+  G TE+++LLL+  A PD+A   G T LH +   G      VLL AGA 
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534

Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
            ++A + G  PLH+    G+L+ A+LLL+  A  D   +    TPLHVAA   + ++A L
Sbjct: 535 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQKVALL 593

Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQD 338
           LL +GA P A    G+TPL  A                  +Q+ S LL+ GA+ +   + 
Sbjct: 594 LLEKGASPHATAKNGYTPLHIAAK-------------KNQMQIASTLLNYGAETNIVTKQ 640

Query: 339 KQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRAL 398
              PLHLA + GH  +V LLL  G + +     G T LH A Q       +   +V   L
Sbjct: 641 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ-------EDKVNVADIL 693

Query: 399 LNHGA 403
             HGA
Sbjct: 694 TKHGA 698



 Score =  123 bits (309), Expect = 3e-28
 Identities = 89/262 (33%), Positives = 127/262 (48%), Gaps = 29/262 (11%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+A  +   +V+ LL++  A   +    G T +H A   GH   V +LL  GA P++
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
            +  G+  LH+    G +E    LLR GA VD R+  EE+TPLH+A+RLG  E+  LLL+
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQ 497

Query: 282 RGACPDARNAEGWTPLLAAC-----DV--------RCQSITDAEATTA-------RCLQL 321
             A PDA    G+TPL  +      DV           S+   +  T          L +
Sbjct: 498 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 557

Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
             LLL   A AD+A ++   PLH+A    +  V  LLL  G S +     G+TPLH A +
Sbjct: 558 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 617

Query: 382 GPAAALAQSPEHVVRALLNHGA 403
                  ++   +   LLN+GA
Sbjct: 618 -------KNQMQIASTLLNYGA 632



 Score =  121 bits (304), Expect = 1e-27
 Identities = 84/242 (34%), Positives = 117/242 (48%), Gaps = 22/242 (9%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLHVAA  G  +V +LLL+RRA  DSA   G T LH A    +     +LL  GA P+ 
Sbjct: 544 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 603

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             ++G  PLH+      ++ A  LL +GA  +  +++   TPLH+A++ GH ++  LLL 
Sbjct: 604 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTLLLD 662

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           +GA        G T L  A      ++ D             +L   GAD DA  +    
Sbjct: 663 KGANIHMSTKSGLTSLHLAAQEDKVNVAD-------------ILTKHGADQDAHTKLGYT 709

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
           PL +AC  G+  +V  LL  G + N     G+TPLH A Q       Q   H++  LL H
Sbjct: 710 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQH 762

Query: 402 GA 403
           GA
Sbjct: 763 GA 764



 Score =  115 bits (289), Expect = 7e-26
 Identities = 77/216 (35%), Positives = 108/216 (50%), Gaps = 15/216 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
           +PLH+AA   H E ++ LL+ +A  D       TALH A   GH     +LL   A+PN 
Sbjct: 313 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 372

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
              +G  PLH+      ++  ELL+++GA +   + E   TP+HVAA +GH+ +  LLL+
Sbjct: 373 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVAAFMGHLNIVLLLLQ 431

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
            GA PD  N  G T L  A           +    RC      LL  GA  DA  +++Q 
Sbjct: 432 NGASPDVTNIRGETALHMAARA-------GQVEVVRC------LLRNGALVDARAREEQT 478

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377
           PLH+A R G   +V+LLL      +     G+TPLH
Sbjct: 479 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 514



 Score =  109 bits (272), Expect = 6e-24
 Identities = 75/218 (34%), Positives = 105/218 (48%), Gaps = 15/218 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLHVAA   + +V  LLL + A P + A  G T LH A           LL  GA+ NI
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             + G  PLHL    G  +   LLL  GA +   S +   T LH+AA+   V +AD+L +
Sbjct: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIH-MSTKSGLTSLHLAAQEDKVNVADILTK 695

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
            GA  DA    G+TPL+ AC                 +++ + LL  GA+ +A  ++   
Sbjct: 696 HGADQDAHTKLGYTPLIVACHYGN-------------VKMVNFLLKQGANVNAKTKNGYT 742

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           PLH A ++GH  ++ +LL  G   N     G+T L  A
Sbjct: 743 PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 780



 Score =  100 bits (248), Expect = 4e-21
 Identities = 88/254 (34%), Positives = 108/254 (42%), Gaps = 42/254 (16%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPL++AA   H +V++ LL   A   +A   G T L  A   GH   V +LL        
Sbjct: 111 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN------ 164

Query: 222 ADQDGK---RPLHLCRGPGTLECAELLLRFGARVD-------GRSEEEEETPLHVAARLG 271
            D  GK     LH+       + A LLL+     D        R+ E   TPLH+AA  G
Sbjct: 165 -DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 223

Query: 272 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331
           +V +A LLL RGA  D     G TPL          +      T     +  LLL  G  
Sbjct: 224 NVNVATLLLNRGAAVDFTARNGITPL---------HVASKRGNT----NMVKLLLDRGGQ 270

Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391
            DA  +D   PLH A R GH  VVELLL  G         G +PLH A QG         
Sbjct: 271 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--------- 321

Query: 392 EHV--VRALLNHGA 403
           +HV  V+ LL H A
Sbjct: 322 DHVECVKHLLQHKA 335



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 76/218 (34%), Positives = 103/218 (47%), Gaps = 15/218 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+AA  G+  V  LLL R A  D +A  G T LH A   G+T  V +LL  G   + 
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             +DG  PLH     G  +  ELLL  GA +  R++    +PLH+AA+  HVE    LL+
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQ 332

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
             A  D    +  T L  A       +T              LLL   A+ +A   +   
Sbjct: 333 HKAPVDDVTLDYLTALHVAAHCGHYRVT-------------KLLLDKRANPNARALNGFT 379

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           PLH+AC++    V+ELL+  G S   +   G TP+H A
Sbjct: 380 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 417



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 78/264 (29%), Positives = 117/264 (44%), Gaps = 33/264 (12%)

Query: 165 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 223
           LH+AA  GH  +++ LL R +  DSA   G TALH A  AG    V VL+  GA+ N   
Sbjct: 47  LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 106

Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR- 282
           Q+G  PL++      ++  + LL  GA     + E+  TPL VA + GH +   +LL   
Sbjct: 107 QNGFTPLYMAAQENHIDVVKYLLENGAN-QSTATEDGFTPLAVALQQGHNQAVAILLEND 165

Query: 283 -------------GACPDARNAEGWTPLLAACDVRCQSITDAEATTARC----------L 319
                            D ++A          DV+ + + +    +             +
Sbjct: 166 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 225

Query: 320 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
            + +LLL+ GA  D   ++   PLH+A +RG+  +V+LLL  G   +     G TPLHCA
Sbjct: 226 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 285

Query: 380 LQGPAAALAQSPEHVVRALLNHGA 403
            +          + VV  LL  GA
Sbjct: 286 AR-------SGHDQVVELLLERGA 302



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 52/149 (34%), Positives = 78/149 (52%), Gaps = 2/149 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+A+  GHT+++ LLL + A    S   G T+LH A          +L   GAD + 
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             + G  PL +    G ++    LL+ GA V+ +++    TPLH AA+ GH  + ++LL+
Sbjct: 703 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQAAQQGHTHIINVLLQ 761

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
            GA P+A  A G T L  A  +   S+ D
Sbjct: 762 HGAKPNATTANGNTALAIAKRLGYISVVD 790



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 66/234 (28%), Positives = 100/234 (42%), Gaps = 32/234 (13%)

Query: 193 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARV 252
           G  ALH A   GH   V  LL  G+  + A + G   LH+    G  E  ++L++ GA +
Sbjct: 43  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 102

Query: 253 DGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC----------- 301
           + +S +   TPL++AA+  H+++   LL  GA       +G+TPL  A            
Sbjct: 103 NAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161

Query: 302 ---DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ----------RPLHLACR 348
              D + +    A    AR     S  L    D +A  Q K            PLH+A  
Sbjct: 162 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 221

Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHG 402
            G+  V  LLL+ G + +     G TPLH A +       +   ++V+ LL+ G
Sbjct: 222 YGNVNVATLLLNRGAAVDFTARNGITPLHVASK-------RGNTNMVKLLLDRG 268



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 48/160 (30%), Positives = 75/160 (46%), Gaps = 14/160 (8%)

Query: 200 ACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEE 259
           A  AG+   V   L  G D N  +Q+G   LHL    G +   + LL  G+ VD  + ++
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDS-ATKK 75

Query: 260 EETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCL 319
             T LH+A+  G  E+  +L++ GA  +A++  G+TPL  A                  +
Sbjct: 76  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ-------------ENHI 122

Query: 320 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 359
            +   LL  GA+   A +D   PL +A ++GH   V +LL
Sbjct: 123 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 1/84 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPL VA   G+ +++  LL++ A  ++    G T LH+A   GHT  ++VLL  GA PN 
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768

Query: 222 ADQDGKRPLHLCRGPGTLECAELL 245
              +G   L + +  G +   + L
Sbjct: 769 TTANGNTALAIAKRLGYISVVDTL 792



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 7/78 (8%)

Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
           L  G D +  +Q+    LHLA + GH  +V+ LL  G S ++    G+T LH       A
Sbjct: 30  LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH------IA 83

Query: 386 ALAQSPEHVVRALLNHGA 403
           +LA   E VV+ L+  GA
Sbjct: 84  SLAGQAE-VVKVLVKEGA 100


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  126 bits (317), Expect = 4e-29
 Identities = 89/245 (36%), Positives = 123/245 (50%), Gaps = 22/245 (8%)

Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGAD 218
           E  TPLH+A+  G TE+++LLL+  A PD+A   G T LH +   G      VLL AGA 
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555

Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
            ++A + G  PLH+    G+L+ A+LLL+  A  D   +    TPLHVAA   + ++A L
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQKVALL 614

Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQD 338
           LL +GA P A    G+TPL  A                  +Q+ S LL+ GA+ +   + 
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAK-------------KNQMQIASTLLNYGAETNIVTKQ 661

Query: 339 KQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRAL 398
              PLHLA + GH  +V LLL  G + +     G T LH A Q       +   +V   L
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ-------EDKVNVADIL 714

Query: 399 LNHGA 403
             HGA
Sbjct: 715 TKHGA 719



 Score =  123 bits (309), Expect = 3e-28
 Identities = 89/262 (33%), Positives = 127/262 (48%), Gaps = 29/262 (11%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+A  +   +V+ LL++  A   +    G T +H A   GH   V +LL  GA P++
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
            +  G+  LH+    G +E    LLR GA VD R+  EE+TPLH+A+RLG  E+  LLL+
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQ 518

Query: 282 RGACPDARNAEGWTPLLAAC-----DV--------RCQSITDAEATTA-------RCLQL 321
             A PDA    G+TPL  +      DV           S+   +  T          L +
Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578

Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
             LLL   A AD+A ++   PLH+A    +  V  LLL  G S +     G+TPLH A +
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638

Query: 382 GPAAALAQSPEHVVRALLNHGA 403
                  ++   +   LLN+GA
Sbjct: 639 -------KNQMQIASTLLNYGA 653



 Score =  121 bits (304), Expect = 1e-27
 Identities = 84/242 (34%), Positives = 117/242 (48%), Gaps = 22/242 (9%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLHVAA  G  +V +LLL+RRA  DSA   G T LH A    +     +LL  GA P+ 
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             ++G  PLH+      ++ A  LL +GA  +  +++   TPLH+A++ GH ++  LLL 
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTLLLD 683

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           +GA        G T L  A      ++ D             +L   GAD DA  +    
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVAD-------------ILTKHGADQDAHTKLGYT 730

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
           PL +AC  G+  +V  LL  G + N     G+TPLH A Q       Q   H++  LL H
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQH 783

Query: 402 GA 403
           GA
Sbjct: 784 GA 785



 Score =  115 bits (289), Expect = 7e-26
 Identities = 77/216 (35%), Positives = 108/216 (50%), Gaps = 15/216 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
           +PLH+AA   H E ++ LL+ +A  D       TALH A   GH     +LL   A+PN 
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
              +G  PLH+      ++  ELL+++GA +   + E   TP+HVAA +GH+ +  LLL+
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVAAFMGHLNIVLLLLQ 452

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
            GA PD  N  G T L  A           +    RC      LL  GA  DA  +++Q 
Sbjct: 453 NGASPDVTNIRGETALHMAARA-------GQVEVVRC------LLRNGALVDARAREEQT 499

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377
           PLH+A R G   +V+LLL      +     G+TPLH
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535



 Score =  109 bits (272), Expect = 6e-24
 Identities = 75/218 (34%), Positives = 105/218 (48%), Gaps = 15/218 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLHVAA   + +V  LLL + A P + A  G T LH A           LL  GA+ NI
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             + G  PLHL    G  +   LLL  GA +   S +   T LH+AA+   V +AD+L +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIH-MSTKSGLTSLHLAAQEDKVNVADILTK 716

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
            GA  DA    G+TPL+ AC                 +++ + LL  GA+ +A  ++   
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGN-------------VKMVNFLLKQGANVNAKTKNGYT 763

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           PLH A ++GH  ++ +LL  G   N     G+T L  A
Sbjct: 764 PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801



 Score =  100 bits (248), Expect = 4e-21
 Identities = 88/254 (34%), Positives = 108/254 (42%), Gaps = 42/254 (16%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPL++AA   H +V++ LL   A   +A   G T L  A   GH   V +LL        
Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN------ 185

Query: 222 ADQDGK---RPLHLCRGPGTLECAELLLRFGARVD-------GRSEEEEETPLHVAARLG 271
            D  GK     LH+       + A LLL+     D        R+ E   TPLH+AA  G
Sbjct: 186 -DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 244

Query: 272 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331
           +V +A LLL RGA  D     G TPL          +      T     +  LLL  G  
Sbjct: 245 NVNVATLLLNRGAAVDFTARNGITPL---------HVASKRGNT----NMVKLLLDRGGQ 291

Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391
            DA  +D   PLH A R GH  VVELLL  G         G +PLH A QG         
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--------- 342

Query: 392 EHV--VRALLNHGA 403
           +HV  V+ LL H A
Sbjct: 343 DHVECVKHLLQHKA 356



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 76/218 (34%), Positives = 103/218 (47%), Gaps = 15/218 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+AA  G+  V  LLL R A  D +A  G T LH A   G+T  V +LL  G   + 
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             +DG  PLH     G  +  ELLL  GA +  R++    +PLH+AA+  HVE    LL+
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQ 353

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
             A  D    +  T L  A       +T              LLL   A+ +A   +   
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVT-------------KLLLDKRANPNARALNGFT 400

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           PLH+AC++    V+ELL+  G S   +   G TP+H A
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 78/264 (29%), Positives = 117/264 (44%), Gaps = 33/264 (12%)

Query: 165 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 223
           LH+AA  GH  +++ LL R +  DSA   G TALH A  AG    V VL+  GA+ N   
Sbjct: 68  LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127

Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR- 282
           Q+G  PL++      ++  + LL  GA     + E+  TPL VA + GH +   +LL   
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGAN-QSTATEDGFTPLAVALQQGHNQAVAILLEND 186

Query: 283 -------------GACPDARNAEGWTPLLAACDVRCQSITDAEATTARC----------L 319
                            D ++A          DV+ + + +    +             +
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 246

Query: 320 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
            + +LLL+ GA  D   ++   PLH+A +RG+  +V+LLL  G   +     G TPLHCA
Sbjct: 247 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 306

Query: 380 LQGPAAALAQSPEHVVRALLNHGA 403
            +          + VV  LL  GA
Sbjct: 307 AR-------SGHDQVVELLLERGA 323



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 52/149 (34%), Positives = 78/149 (52%), Gaps = 2/149 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+A+  GHT+++ LLL + A    S   G T+LH A          +L   GAD + 
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             + G  PL +    G ++    LL+ GA V+ +++    TPLH AA+ GH  + ++LL+
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQAAQQGHTHIINVLLQ 782

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
            GA P+A  A G T L  A  +   S+ D
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVD 811



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 66/234 (28%), Positives = 100/234 (42%), Gaps = 32/234 (13%)

Query: 193 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARV 252
           G  ALH A   GH   V  LL  G+  + A + G   LH+    G  E  ++L++ GA +
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123

Query: 253 DGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC----------- 301
           + +S +   TPL++AA+  H+++   LL  GA       +G+TPL  A            
Sbjct: 124 NAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182

Query: 302 ---DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ----------RPLHLACR 348
              D + +    A    AR     S  L    D +A  Q K            PLH+A  
Sbjct: 183 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242

Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHG 402
            G+  V  LLL+ G + +     G TPLH A +       +   ++V+ LL+ G
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASK-------RGNTNMVKLLLDRG 289



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 53/178 (29%), Positives = 83/178 (46%), Gaps = 15/178 (8%)

Query: 182 RRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLEC 241
           +RR RP  +    + L  A  AG+   V   L  G D N  +Q+G   LHL    G +  
Sbjct: 21  QRRKRPKKSDSNASFLR-AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGL 79

Query: 242 AELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC 301
            + LL  G+ VD  + ++  T LH+A+  G  E+  +L++ GA  +A++  G+TPL  A 
Sbjct: 80  VQELLGRGSSVDS-ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 138

Query: 302 DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 359
                            + +   LL  GA+   A +D   PL +A ++GH   V +LL
Sbjct: 139 Q-------------ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 1/84 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPL VA   G+ +++  LL++ A  ++    G T LH+A   GHT  ++VLL  GA PN 
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789

Query: 222 ADQDGKRPLHLCRGPGTLECAELL 245
              +G   L + +  G +   + L
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTL 813



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 7/78 (8%)

Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
           L  G D +  +Q+    LHLA + GH  +V+ LL  G S ++    G+T LH       A
Sbjct: 51  LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH------IA 104

Query: 386 ALAQSPEHVVRALLNHGA 403
           +LA   E VV+ L+  GA
Sbjct: 105 SLAGQAE-VVKVLVKEGA 121


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  126 bits (317), Expect = 4e-29
 Identities = 89/245 (36%), Positives = 123/245 (50%), Gaps = 22/245 (8%)

Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGAD 218
           E  TPLH+A+  G TE+++LLL+  A PD+A   G T LH +   G      VLL AGA 
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555

Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
            ++A + G  PLH+    G+L+ A+LLL+  A  D   +    TPLHVAA   + ++A L
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQKVALL 614

Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQD 338
           LL +GA P A    G+TPL  A                  +Q+ S LL+ GA+ +   + 
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAK-------------KNQMQIASTLLNYGAETNIVTKQ 661

Query: 339 KQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRAL 398
              PLHLA + GH  +V LLL  G + +     G T LH A Q       +   +V   L
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ-------EDKVNVADIL 714

Query: 399 LNHGA 403
             HGA
Sbjct: 715 TKHGA 719



 Score =  123 bits (309), Expect = 3e-28
 Identities = 89/262 (33%), Positives = 127/262 (48%), Gaps = 29/262 (11%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+A  +   +V+ LL++  A   +    G T +H A   GH   V +LL  GA P++
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
            +  G+  LH+    G +E    LLR GA VD R+  EE+TPLH+A+RLG  E+  LLL+
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQ 518

Query: 282 RGACPDARNAEGWTPLLAAC-----DV--------RCQSITDAEATTA-------RCLQL 321
             A PDA    G+TPL  +      DV           S+   +  T          L +
Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578

Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
             LLL   A AD+A ++   PLH+A    +  V  LLL  G S +     G+TPLH A +
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638

Query: 382 GPAAALAQSPEHVVRALLNHGA 403
                  ++   +   LLN+GA
Sbjct: 639 -------KNQMQIASTLLNYGA 653



 Score =  121 bits (304), Expect = 1e-27
 Identities = 84/242 (34%), Positives = 117/242 (48%), Gaps = 22/242 (9%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLHVAA  G  +V +LLL+RRA  DSA   G T LH A    +     +LL  GA P+ 
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             ++G  PLH+      ++ A  LL +GA  +  +++   TPLH+A++ GH ++  LLL 
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTLLLD 683

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           +GA        G T L  A      ++ D             +L   GAD DA  +    
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVAD-------------ILTKHGADQDAHTKLGYT 730

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
           PL +AC  G+  +V  LL  G + N     G+TPLH A Q       Q   H++  LL H
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQH 783

Query: 402 GA 403
           GA
Sbjct: 784 GA 785



 Score =  115 bits (289), Expect = 7e-26
 Identities = 77/216 (35%), Positives = 108/216 (50%), Gaps = 15/216 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
           +PLH+AA   H E ++ LL+ +A  D       TALH A   GH     +LL   A+PN 
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
              +G  PLH+      ++  ELL+++GA +   + E   TP+HVAA +GH+ +  LLL+
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVAAFMGHLNIVLLLLQ 452

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
            GA PD  N  G T L  A           +    RC      LL  GA  DA  +++Q 
Sbjct: 453 NGASPDVTNIRGETALHMAARA-------GQVEVVRC------LLRNGALVDARAREEQT 499

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377
           PLH+A R G   +V+LLL      +     G+TPLH
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535



 Score =  109 bits (272), Expect = 6e-24
 Identities = 75/218 (34%), Positives = 105/218 (48%), Gaps = 15/218 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLHVAA   + +V  LLL + A P + A  G T LH A           LL  GA+ NI
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             + G  PLHL    G  +   LLL  GA +   S +   T LH+AA+   V +AD+L +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIH-MSTKSGLTSLHLAAQEDKVNVADILTK 716

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
            GA  DA    G+TPL+ AC                 +++ + LL  GA+ +A  ++   
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGN-------------VKMVNFLLKQGANVNAKTKNGYT 763

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           PLH A ++GH  ++ +LL  G   N     G+T L  A
Sbjct: 764 PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801



 Score =  100 bits (248), Expect = 4e-21
 Identities = 88/254 (34%), Positives = 108/254 (42%), Gaps = 42/254 (16%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPL++AA   H +V++ LL   A   +A   G T L  A   GH   V +LL        
Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN------ 185

Query: 222 ADQDGK---RPLHLCRGPGTLECAELLLRFGARVD-------GRSEEEEETPLHVAARLG 271
            D  GK     LH+       + A LLL+     D        R+ E   TPLH+AA  G
Sbjct: 186 -DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 244

Query: 272 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331
           +V +A LLL RGA  D     G TPL          +      T     +  LLL  G  
Sbjct: 245 NVNVATLLLNRGAAVDFTARNGITPL---------HVASKRGNT----NMVKLLLDRGGQ 291

Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391
            DA  +D   PLH A R GH  VVELLL  G         G +PLH A QG         
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--------- 342

Query: 392 EHV--VRALLNHGA 403
           +HV  V+ LL H A
Sbjct: 343 DHVECVKHLLQHKA 356



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 76/218 (34%), Positives = 103/218 (47%), Gaps = 15/218 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+AA  G+  V  LLL R A  D +A  G T LH A   G+T  V +LL  G   + 
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             +DG  PLH     G  +  ELLL  GA +  R++    +PLH+AA+  HVE    LL+
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQ 353

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
             A  D    +  T L  A       +T              LLL   A+ +A   +   
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVT-------------KLLLDKRANPNARALNGFT 400

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           PLH+AC++    V+ELL+  G S   +   G TP+H A
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 78/264 (29%), Positives = 117/264 (44%), Gaps = 33/264 (12%)

Query: 165 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 223
           LH+AA  GH  +++ LL R +  DSA   G TALH A  AG    V VL+  GA+ N   
Sbjct: 68  LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127

Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR- 282
           Q+G  PL++      ++  + LL  GA     + E+  TPL VA + GH +   +LL   
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGAN-QSTATEDGFTPLAVALQQGHNQAVAILLEND 186

Query: 283 -------------GACPDARNAEGWTPLLAACDVRCQSITDAEATTARC----------L 319
                            D ++A          DV+ + + +    +             +
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 246

Query: 320 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
            + +LLL+ GA  D   ++   PLH+A +RG+  +V+LLL  G   +     G TPLHCA
Sbjct: 247 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 306

Query: 380 LQGPAAALAQSPEHVVRALLNHGA 403
            +          + VV  LL  GA
Sbjct: 307 AR-------SGHDQVVELLLERGA 323



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 52/149 (34%), Positives = 78/149 (52%), Gaps = 2/149 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+A+  GHT+++ LLL + A    S   G T+LH A          +L   GAD + 
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             + G  PL +    G ++    LL+ GA V+ +++    TPLH AA+ GH  + ++LL+
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQAAQQGHTHIINVLLQ 782

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
            GA P+A  A G T L  A  +   S+ D
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVD 811



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 66/234 (28%), Positives = 100/234 (42%), Gaps = 32/234 (13%)

Query: 193 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARV 252
           G  ALH A   GH   V  LL  G+  + A + G   LH+    G  E  ++L++ GA +
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123

Query: 253 DGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC----------- 301
           + +S +   TPL++AA+  H+++   LL  GA       +G+TPL  A            
Sbjct: 124 NAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182

Query: 302 ---DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ----------RPLHLACR 348
              D + +    A    AR     S  L    D +A  Q K            PLH+A  
Sbjct: 183 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242

Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHG 402
            G+  V  LLL+ G + +     G TPLH A +       +   ++V+ LL+ G
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASK-------RGNTNMVKLLLDRG 289



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 53/178 (29%), Positives = 83/178 (46%), Gaps = 15/178 (8%)

Query: 182 RRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLEC 241
           +RR RP  +    + L  A  AG+   V   L  G D N  +Q+G   LHL    G +  
Sbjct: 21  QRRKRPKKSDSNASFLR-AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGL 79

Query: 242 AELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC 301
            + LL  G+ VD  + ++  T LH+A+  G  E+  +L++ GA  +A++  G+TPL  A 
Sbjct: 80  VQELLGRGSSVDS-ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 138

Query: 302 DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 359
                            + +   LL  GA+   A +D   PL +A ++GH   V +LL
Sbjct: 139 Q-------------ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 1/84 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPL VA   G+ +++  LL++ A  ++    G T LH+A   GHT  ++VLL  GA PN 
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789

Query: 222 ADQDGKRPLHLCRGPGTLECAELL 245
              +G   L + +  G +   + L
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTL 813



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 7/78 (8%)

Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
           L  G D +  +Q+    LHLA + GH  +V+ LL  G S ++    G+T LH       A
Sbjct: 51  LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH------IA 104

Query: 386 ALAQSPEHVVRALLNHGA 403
           +LA   E VV+ L+  GA
Sbjct: 105 SLAGQAE-VVKVLVKEGA 121


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  122 bits (307), Expect = 5e-28
 Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+A+ RG+  ++RLLL R A+ ++      T LH A   GH     +LL  GA    
Sbjct: 274 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 333

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             ++G  P+H+      L+C  LLL++ A +D  + +   TPLHVAA  GH  +A +LL 
Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 392

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           +GA P++R   G+TPL  AC                 +++  LLL  GA  DA  +    
Sbjct: 393 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 439

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
           PLH+A   GH  +V+ LL  G S N  +    TPLH A +     +A+
Sbjct: 440 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 487



 Score =  120 bits (302), Expect = 2e-27
 Identities = 91/266 (34%), Positives = 123/266 (46%), Gaps = 29/266 (10%)

Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGAD 218
           ++ TPLH+AA  GHTEV + LL+ +A+ ++ A   +T LH A   GHT  V +LL   A+
Sbjct: 469 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 528

Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
           PN+A   G  PLH+    G +E    LL   A       ++  TPLHVAA+ G V +A+L
Sbjct: 529 PNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAEL 587

Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318
           LL R A P+A    G TPL  A       I                        A     
Sbjct: 588 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 647

Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378
           +++   LL  G  A+A       PLHLA + GHA +V LLLS   + N  +  G TPLH 
Sbjct: 648 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 707

Query: 379 ALQGPAAALAQSPEHVVRALLNHGAV 404
             Q       +    V   L+ HG +
Sbjct: 708 VAQ-------EGHVPVADVLIKHGVM 726



 Score =  119 bits (297), Expect = 8e-27
 Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
           +P+H+AA   H + +RLLL+  A  D       T LH A   GH     VLL  GA PN 
Sbjct: 340 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 399

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
              +G  PLH+      +   ELLL+ GA +D  +E    TPLHVA+ +GH+ +   LL+
Sbjct: 400 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 458

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           RGA P+  N +  TPL  A               A   ++   LL   A  +A  +D Q 
Sbjct: 459 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 505

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           PLH A R GH  +V+LLL    + N     GHTPLH A
Sbjct: 506 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 543



 Score =  110 bits (275), Expect = 3e-24
 Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLHVAA  G   V  LLL R A P++A   G T LH A    +   V +LL  G  P+ 
Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
              +G  PLH+      +E A  LL++G   +  S +   TPLH+AA+ GH E+  LLL 
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 689

Query: 282 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 321
           + A  +  N  G TPL        +   DV  +     +ATT               ++L
Sbjct: 690 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 749

Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
              LL   AD +A  +    PLH A ++GH  +V LLL  G S N +   G TPL  A
Sbjct: 750 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807



 Score =  101 bits (251), Expect = 2e-21
 Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%)

Query: 159 EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 188
           E+  TPL VA  +GH                             T    +LL+    PD 
Sbjct: 175 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 234

Query: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248
            +  G T LH A    +     +LL  GA  N   Q+G  PLH+    G +    LLL  
Sbjct: 235 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 294

Query: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 296
           GA+++ ++ ++E TPLH AAR GHV ++++LL  GA   A+   G +P            
Sbjct: 295 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 353

Query: 297 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 348
             LL   D     IT    T     A C   ++  +LL  GA  ++   +   PLH+AC+
Sbjct: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 413

Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
           + H  V+ELLL  G S + +   G TPLH      A+ +   P  +V+ LL  GA
Sbjct: 414 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 461



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           T LH+AA  G  EV+R L+   A  ++ +  G T L+ A    H   V  LL  GA+ N+
Sbjct: 113 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 172

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
           A +DG  PL +    G       L+ +G +   R        LH+AAR      A +LL+
Sbjct: 173 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 227

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
               PD  +  G+TPL  A                  L +  LLL+ GA  +   Q+   
Sbjct: 228 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 274

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
           PLH+A RRG+  +V LLL  G    T      TPLHCA +     +++        LL+H
Sbjct: 275 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 327

Query: 402 GA 403
           GA
Sbjct: 328 GA 329



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+AA  GH E++ LLL ++A  +     G T LH     GH     VL+  G   + 
Sbjct: 670 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 729

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             + G  PLH+    G ++  + LL+  A V+ +++    +PLH AA+ GH ++  LLL+
Sbjct: 730 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 788

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
            GA P+  +++G TPL  A  +   S+TD
Sbjct: 789 NGASPNEVSSDGTTPLAIAKRLGYISVTD 817



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 42/118 (35%), Positives = 58/118 (49%), Gaps = 2/118 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+ A  GH  V  +L++     D+    G T LH A   G+   V  LL   AD N 
Sbjct: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 762

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279
             + G  PLH     G  +   LLL+ GA  +  S +   TPL +A RLG++ + D+L
Sbjct: 763 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT-TPLAIAKRLGYISVTDVL 819



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%)

Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
           L  G D +  +Q+    LHLA + GH  +V  LL   +   T    G+T LH       A
Sbjct: 65  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 118

Query: 386 ALAQSPEHVVRALLNHGA 403
           ALA   E VVR L+N+GA
Sbjct: 119 ALAGQDE-VVRELVNYGA 135


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  122 bits (307), Expect = 5e-28
 Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+A+ RG+  ++RLLL R A+ ++      T LH A   GH     +LL  GA    
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             ++G  P+H+      L+C  LLL++ A +D  + +   TPLHVAA  GH  +A +LL 
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           +GA P++R   G+TPL  AC                 +++  LLL  GA  DA  +    
Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
           PLH+A   GH  +V+ LL  G S N  +    TPLH A +     +A+
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454



 Score =  120 bits (302), Expect = 2e-27
 Identities = 91/266 (34%), Positives = 123/266 (46%), Gaps = 29/266 (10%)

Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGAD 218
           ++ TPLH+AA  GHTEV + LL+ +A+ ++ A   +T LH A   GHT  V +LL   A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495

Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
           PN+A   G  PLH+    G +E    LL   A       ++  TPLHVAA+ G V +A+L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAEL 554

Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318
           LL R A P+A    G TPL  A       I                        A     
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614

Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378
           +++   LL  G  A+A       PLHLA + GHA +V LLLS   + N  +  G TPLH 
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674

Query: 379 ALQGPAAALAQSPEHVVRALLNHGAV 404
             Q       +    V   L+ HG +
Sbjct: 675 VAQ-------EGHVPVADVLIKHGVM 693



 Score =  119 bits (297), Expect = 8e-27
 Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
           +P+H+AA   H + +RLLL+  A  D       T LH A   GH     VLL  GA PN 
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
              +G  PLH+      +   ELLL+ GA +D  +E    TPLHVA+ +GH+ +   LL+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           RGA P+  N +  TPL  A               A   ++   LL   A  +A  +D Q 
Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           PLH A R GH  +V+LLL    + N     GHTPLH A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510



 Score =  110 bits (275), Expect = 3e-24
 Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLHVAA  G   V  LLL R A P++A   G T LH A    +   V +LL  G  P+ 
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
              +G  PLH+      +E A  LL++G   +  S +   TPLH+AA+ GH E+  LLL 
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656

Query: 282 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 321
           + A  +  N  G TPL        +   DV  +     +ATT               ++L
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
              LL   AD +A  +    PLH A ++GH  +V LLL  G S N +   G TPL  A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  101 bits (251), Expect = 2e-21
 Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%)

Query: 159 EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 188
           E+  TPL VA  +GH                             T    +LL+    PD 
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201

Query: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248
            +  G T LH A    +     +LL  GA  N   Q+G  PLH+    G +    LLL  
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261

Query: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 296
           GA+++ ++ ++E TPLH AAR GHV ++++LL  GA   A+   G +P            
Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 297 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 348
             LL   D     IT    T     A C   ++  +LL  GA  ++   +   PLH+AC+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380

Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
           + H  V+ELLL  G S + +   G TPLH      A+ +   P  +V+ LL  GA
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           T LH+AA  G  EV+R L+   A  ++ +  G T L+ A    H   V  LL  GA+ N+
Sbjct: 80  TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
           A +DG  PL +    G       L+ +G +   R        LH+AAR      A +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
               PD  +  G+TPL  A                  L +  LLL+ GA  +   Q+   
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
           PLH+A RRG+  +V LLL  G    T      TPLHCA +     +++        LL+H
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294

Query: 402 GA 403
           GA
Sbjct: 295 GA 296



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+AA  GH E++ LLL ++A  +     G T LH     GH     VL+  G   + 
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             + G  PLH+    G ++  + LL+  A V+ +++    +PLH AA+ GH ++  LLL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
            GA P+  +++G TPL  A  +   S+TD
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 42/118 (35%), Positives = 58/118 (49%), Gaps = 2/118 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+ A  GH  V  +L++     D+    G T LH A   G+   V  LL   AD N 
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279
             + G  PLH     G  +   LLL+ GA  +  S +   TPL +A RLG++ + D+L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT-TPLAIAKRLGYISVTDVL 786



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%)

Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
           L  G D +  +Q+    LHLA + GH  +V  LL   +   T    G+T LH       A
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85

Query: 386 ALAQSPEHVVRALLNHGA 403
           ALA   E VVR L+N+GA
Sbjct: 86  ALAGQDE-VVRELVNYGA 102


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  122 bits (307), Expect = 5e-28
 Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+A+ RG+  ++RLLL R A+ ++      T LH A   GH     +LL  GA    
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             ++G  P+H+      L+C  LLL++ A +D  + +   TPLHVAA  GH  +A +LL 
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           +GA P++R   G+TPL  AC                 +++  LLL  GA  DA  +    
Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
           PLH+A   GH  +V+ LL  G S N  +    TPLH A +     +A+
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454



 Score =  120 bits (302), Expect = 2e-27
 Identities = 91/266 (34%), Positives = 123/266 (46%), Gaps = 29/266 (10%)

Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGAD 218
           ++ TPLH+AA  GHTEV + LL+ +A+ ++ A   +T LH A   GHT  V +LL   A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495

Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
           PN+A   G  PLH+    G +E    LL   A       ++  TPLHVAA+ G V +A+L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAEL 554

Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318
           LL R A P+A    G TPL  A       I                        A     
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614

Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378
           +++   LL  G  A+A       PLHLA + GHA +V LLLS   + N  +  G TPLH 
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674

Query: 379 ALQGPAAALAQSPEHVVRALLNHGAV 404
             Q       +    V   L+ HG +
Sbjct: 675 VAQ-------EGHVPVADVLIKHGVM 693



 Score =  119 bits (297), Expect = 8e-27
 Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
           +P+H+AA   H + +RLLL+  A  D       T LH A   GH     VLL  GA PN 
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
              +G  PLH+      +   ELLL+ GA +D  +E    TPLHVA+ +GH+ +   LL+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           RGA P+  N +  TPL  A               A   ++   LL   A  +A  +D Q 
Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           PLH A R GH  +V+LLL    + N     GHTPLH A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510



 Score =  110 bits (275), Expect = 3e-24
 Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLHVAA  G   V  LLL R A P++A   G T LH A    +   V +LL  G  P+ 
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
              +G  PLH+      +E A  LL++G   +  S +   TPLH+AA+ GH E+  LLL 
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656

Query: 282 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 321
           + A  +  N  G TPL        +   DV  +     +ATT               ++L
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
              LL   AD +A  +    PLH A ++GH  +V LLL  G S N +   G TPL  A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  101 bits (251), Expect = 2e-21
 Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%)

Query: 159 EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 188
           E+  TPL VA  +GH                             T    +LL+    PD 
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201

Query: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248
            +  G T LH A    +     +LL  GA  N   Q+G  PLH+    G +    LLL  
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261

Query: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 296
           GA+++ ++ ++E TPLH AAR GHV ++++LL  GA   A+   G +P            
Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 297 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 348
             LL   D     IT    T     A C   ++  +LL  GA  ++   +   PLH+AC+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380

Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
           + H  V+ELLL  G S + +   G TPLH      A+ +   P  +V+ LL  GA
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           T LH+AA  G  EV+R L+   A  ++ +  G T L+ A    H   V  LL  GA+ N+
Sbjct: 80  TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
           A +DG  PL +    G       L+ +G +   R        LH+AAR      A +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
               PD  +  G+TPL  A                  L +  LLL+ GA  +   Q+   
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
           PLH+A RRG+  +V LLL  G    T      TPLHCA +     +++        LL+H
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294

Query: 402 GA 403
           GA
Sbjct: 295 GA 296



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+AA  GH E++ LLL ++A  +     G T LH     GH     VL+  G   + 
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             + G  PLH+    G ++  + LL+  A V+ +++    +PLH AA+ GH ++  LLL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
            GA P+  +++G TPL  A  +   S+TD
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 42/118 (35%), Positives = 58/118 (49%), Gaps = 2/118 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+ A  GH  V  +L++     D+    G T LH A   G+   V  LL   AD N 
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279
             + G  PLH     G  +   LLL+ GA  +  S +   TPL +A RLG++ + D+L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT-TPLAIAKRLGYISVTDVL 786



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%)

Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
           L  G D +  +Q+    LHLA + GH  +V  LL   +   T    G+T LH       A
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85

Query: 386 ALAQSPEHVVRALLNHGA 403
           ALA   E VVR L+N+GA
Sbjct: 86  ALAGQDE-VVRELVNYGA 102


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  122 bits (307), Expect = 5e-28
 Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+A+ RG+  ++RLLL R A+ ++      T LH A   GH     +LL  GA    
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             ++G  P+H+      L+C  LLL++ A +D  + +   TPLHVAA  GH  +A +LL 
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           +GA P++R   G+TPL  AC                 +++  LLL  GA  DA  +    
Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
           PLH+A   GH  +V+ LL  G S N  +    TPLH A +     +A+
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454



 Score =  120 bits (302), Expect = 2e-27
 Identities = 91/266 (34%), Positives = 123/266 (46%), Gaps = 29/266 (10%)

Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGAD 218
           ++ TPLH+AA  GHTEV + LL+ +A+ ++ A   +T LH A   GHT  V +LL   A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495

Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
           PN+A   G  PLH+    G +E    LL   A       ++  TPLHVAA+ G V +A+L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAEL 554

Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318
           LL R A P+A    G TPL  A       I                        A     
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614

Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378
           +++   LL  G  A+A       PLHLA + GHA +V LLLS   + N  +  G TPLH 
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674

Query: 379 ALQGPAAALAQSPEHVVRALLNHGAV 404
             Q       +    V   L+ HG +
Sbjct: 675 VAQ-------EGHVPVADVLIKHGVM 693



 Score =  119 bits (297), Expect = 8e-27
 Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
           +P+H+AA   H + +RLLL+  A  D       T LH A   GH     VLL  GA PN 
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
              +G  PLH+      +   ELLL+ GA +D  +E    TPLHVA+ +GH+ +   LL+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           RGA P+  N +  TPL  A               A   ++   LL   A  +A  +D Q 
Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           PLH A R GH  +V+LLL    + N     GHTPLH A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510



 Score =  110 bits (275), Expect = 3e-24
 Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLHVAA  G   V  LLL R A P++A   G T LH A    +   V +LL  G  P+ 
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
              +G  PLH+      +E A  LL++G   +  S +   TPLH+AA+ GH E+  LLL 
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656

Query: 282 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 321
           + A  +  N  G TPL        +   DV  +     +ATT               ++L
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
              LL   AD +A  +    PLH A ++GH  +V LLL  G S N +   G TPL  A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  101 bits (251), Expect = 2e-21
 Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%)

Query: 159 EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 188
           E+  TPL VA  +GH                             T    +LL+    PD 
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201

Query: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248
            +  G T LH A    +     +LL  GA  N   Q+G  PLH+    G +    LLL  
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261

Query: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 296
           GA+++ ++ ++E TPLH AAR GHV ++++LL  GA   A+   G +P            
Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 297 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 348
             LL   D     IT    T     A C   ++  +LL  GA  ++   +   PLH+AC+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380

Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
           + H  V+ELLL  G S + +   G TPLH      A+ +   P  +V+ LL  GA
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           T LH+AA  G  EV+R L+   A  ++ +  G T L+ A    H   V  LL  GA+ N+
Sbjct: 80  TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
           A +DG  PL +    G       L+ +G +   R        LH+AAR      A +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
               PD  +  G+TPL  A                  L +  LLL+ GA  +   Q+   
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
           PLH+A RRG+  +V LLL  G    T      TPLHCA +     +++        LL+H
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294

Query: 402 GA 403
           GA
Sbjct: 295 GA 296



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+AA  GH E++ LLL ++A  +     G T LH     GH     VL+  G   + 
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             + G  PLH+    G ++  + LL+  A V+ +++    +PLH AA+ GH ++  LLL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
            GA P+  +++G TPL  A  +   S+TD
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 42/118 (35%), Positives = 58/118 (49%), Gaps = 2/118 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+ A  GH  V  +L++     D+    G T LH A   G+   V  LL   AD N 
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279
             + G  PLH     G  +   LLL+ GA  +  S +   TPL +A RLG++ + D+L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT-TPLAIAKRLGYISVTDVL 786



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%)

Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
           L  G D +  +Q+    LHLA + GH  +V  LL   +   T    G+T LH       A
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85

Query: 386 ALAQSPEHVVRALLNHGA 403
           ALA   E VVR L+N+GA
Sbjct: 86  ALAGQDE-VVRELVNYGA 102


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  122 bits (307), Expect = 5e-28
 Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+A+ RG+  ++RLLL R A+ ++      T LH A   GH     +LL  GA    
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             ++G  P+H+      L+C  LLL++ A +D  + +   TPLHVAA  GH  +A +LL 
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           +GA P++R   G+TPL  AC                 +++  LLL  GA  DA  +    
Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
           PLH+A   GH  +V+ LL  G S N  +    TPLH A +     +A+
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454



 Score =  120 bits (302), Expect = 2e-27
 Identities = 91/266 (34%), Positives = 123/266 (46%), Gaps = 29/266 (10%)

Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGAD 218
           ++ TPLH+AA  GHTEV + LL+ +A+ ++ A   +T LH A   GHT  V +LL   A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495

Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
           PN+A   G  PLH+    G +E    LL   A       ++  TPLHVAA+ G V +A+L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAEL 554

Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318
           LL R A P+A    G TPL  A       I                        A     
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614

Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378
           +++   LL  G  A+A       PLHLA + GHA +V LLLS   + N  +  G TPLH 
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674

Query: 379 ALQGPAAALAQSPEHVVRALLNHGAV 404
             Q       +    V   L+ HG +
Sbjct: 675 VAQ-------EGHVPVADVLIKHGVM 693



 Score =  119 bits (297), Expect = 8e-27
 Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
           +P+H+AA   H + +RLLL+  A  D       T LH A   GH     VLL  GA PN 
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
              +G  PLH+      +   ELLL+ GA +D  +E    TPLHVA+ +GH+ +   LL+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           RGA P+  N +  TPL  A               A   ++   LL   A  +A  +D Q 
Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           PLH A R GH  +V+LLL    + N     GHTPLH A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510



 Score =  110 bits (275), Expect = 3e-24
 Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLHVAA  G   V  LLL R A P++A   G T LH A    +   V +LL  G  P+ 
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
              +G  PLH+      +E A  LL++G   +  S +   TPLH+AA+ GH E+  LLL 
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656

Query: 282 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 321
           + A  +  N  G TPL        +   DV  +     +ATT               ++L
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
              LL   AD +A  +    PLH A ++GH  +V LLL  G S N +   G TPL  A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  101 bits (251), Expect = 2e-21
 Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%)

Query: 159 EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 188
           E+  TPL VA  +GH                             T    +LL+    PD 
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201

Query: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248
            +  G T LH A    +     +LL  GA  N   Q+G  PLH+    G +    LLL  
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261

Query: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 296
           GA+++ ++ ++E TPLH AAR GHV ++++LL  GA   A+   G +P            
Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 297 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 348
             LL   D     IT    T     A C   ++  +LL  GA  ++   +   PLH+AC+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380

Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
           + H  V+ELLL  G S + +   G TPLH      A+ +   P  +V+ LL  GA
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           T LH+AA  G  EV+R L+   A  ++ +  G T L+ A    H   V  LL  GA+ N+
Sbjct: 80  TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
           A +DG  PL +    G       L+ +G +   R        LH+AAR      A +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
               PD  +  G+TPL  A                  L +  LLL+ GA  +   Q+   
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
           PLH+A RRG+  +V LLL  G    T      TPLHCA +     +++        LL+H
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294

Query: 402 GA 403
           GA
Sbjct: 295 GA 296



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+AA  GH E++ LLL ++A  +     G T LH     GH     VL+  G   + 
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             + G  PLH+    G ++  + LL+  A V+ +++    +PLH AA+ GH ++  LLL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
            GA P+  +++G TPL  A  +   S+TD
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 42/118 (35%), Positives = 58/118 (49%), Gaps = 2/118 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+ A  GH  V  +L++     D+    G T LH A   G+   V  LL   AD N 
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279
             + G  PLH     G  +   LLL+ GA  +  S +   TPL +A RLG++ + D+L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT-TPLAIAKRLGYISVTDVL 786



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%)

Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
           L  G D +  +Q+    LHLA + GH  +V  LL   +   T    G+T LH       A
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85

Query: 386 ALAQSPEHVVRALLNHGA 403
           ALA   E VVR L+N+GA
Sbjct: 86  ALAGQDE-VVRELVNYGA 102


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  120 bits (301), Expect = 3e-27
 Identities = 83/242 (34%), Positives = 114/242 (47%), Gaps = 22/242 (9%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
           +PLH+A    H   ++LLL+     D       TALH A   GH     VLL   A+PN 
Sbjct: 336 SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNA 395

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
              +G  PLH+      ++  ELLL+ GA +   +E    TP+HVAA +GHV +   L+ 
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGL-TPIHVAAFMGHVNIVSQLMH 454

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
            GA P+  N  G T L  A           +A   R       L+  GA  +A  +D Q 
Sbjct: 455 HGASPNTTNVRGETALHMAA-------RSGQAEVVR------YLVQDGAQVEAKAKDDQT 501

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
           PLH++ R G A +V+ LL  G S N     G+TPLH + +       +  E V   LL+H
Sbjct: 502 PLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAR-------EGHEDVAAFLLDH 554

Query: 402 GA 403
           GA
Sbjct: 555 GA 556



 Score =  119 bits (298), Expect = 6e-27
 Identities = 83/243 (34%), Positives = 119/243 (48%), Gaps = 24/243 (9%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLHVAA  G  EV  LLL++ A PD+A   G T LH A    +     +LL  GA P+ 
Sbjct: 567 TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA 626

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
           A ++G  PLH+      ++ A  LL +GA  +  + +   + +H+AA+ GHV++  LLL 
Sbjct: 627 AAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIAS-VHLAAQEGHVDMVSLLLG 685

Query: 282 RGACPDARNAEGWTPL-LAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 340
           R A  +  N  G TPL LAA + R              + +  +L++ GA  DA  +   
Sbjct: 686 RNANVNLSNKSGLTPLHLAAQEDR--------------VNVAEVLVNQGAHVDAQTKMGY 731

Query: 341 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN 400
            PLH+ C  G+  +V  LL      N     G+TPLH A Q       Q   H++  LL 
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQ 784

Query: 401 HGA 403
           + A
Sbjct: 785 NNA 787



 Score =  119 bits (297), Expect = 8e-27
 Identities = 84/242 (34%), Positives = 118/242 (48%), Gaps = 22/242 (9%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLHVA+ RG+  +++LLL R A+ D+    G T LH    +GH   V +LL   A    
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
             ++G  PLH+      L C +LLL+    VD  +  +  T LHVAA  GH ++A +LL 
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVT-NDYLTALHVAAHCGHYKVAKVLLD 388

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           + A P+A+   G+TPL  AC                 +++  LLL  GA   A  +    
Sbjct: 389 KKANPNAKALNGFTPLHIAC-------------KKNRIKVMELLLKHGASIQAVTESGLT 435

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
           P+H+A   GH  +V  L+  G S NT +  G T LH A +   A        VVR L+  
Sbjct: 436 PIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQA-------EVVRYLVQD 488

Query: 402 GA 403
           GA
Sbjct: 489 GA 490



 Score =  118 bits (296), Expect = 1e-26
 Identities = 89/262 (33%), Positives = 124/262 (47%), Gaps = 29/262 (11%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           T LH+AA  G  EV+R L++  A+ ++ A   +T LH +   G    V  LL  GA PN 
Sbjct: 468 TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
           A   G  PLHL    G  + A  LL  GA +   + ++  TPLHVAA+ G +E+A+LLL+
Sbjct: 528 ATTSGYTPLHLSAREGHEDVAAFLLDHGASLS-ITTKKGFTPLHVAAKYGKLEVANLLLQ 586

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSIT----DAEATTARC----------------LQL 321
           + A PDA    G TPL  A     Q +     D  A+                    + +
Sbjct: 587 KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDI 646

Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
            + LL  GADA+A  +     +HLA + GH  +V LLL    + N  +  G TPLH A Q
Sbjct: 647 ATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQ 706

Query: 382 GPAAALAQSPEHVVRALLNHGA 403
                  +   +V   L+N GA
Sbjct: 707 -------EDRVNVAEVLVNQGA 721



 Score =  101 bits (251), Expect = 2e-21
 Identities = 83/256 (32%), Positives = 118/256 (46%), Gaps = 25/256 (9%)

Query: 165 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 223
           LH+A+  GH EV+  LL+R A  D+A   G TALH A  AG    V VL+  GA+ N   
Sbjct: 78  LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137

Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRG 283
           Q+G  PL++      LE  + LL  GA     + E+  TPL VA + GH ++  LLL   
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLAVALQQGHDQVVSLLLEND 196

Query: 284 ACPDAR------NAEGWTPLLAACDVRCQSITDAEATTARC----------LQLCSLLLS 327
                R       A       AA  ++  +  D E+ +             + + +LLL+
Sbjct: 197 TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLN 256

Query: 328 AGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAAL 387
             A  D   ++   PLH+A +RG+A +V+LLL  G   +     G TPLHC  +      
Sbjct: 257 RAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGAR------ 310

Query: 388 AQSPEHVVRALLNHGA 403
               E VV  LL+  A
Sbjct: 311 -SGHEQVVEMLLDRAA 325



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 79/265 (29%), Positives = 110/265 (41%), Gaps = 31/265 (11%)

Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGAD 218
           E+  TPL VA  +GH +V+ LLL    +         ALH A     T    +LL    +
Sbjct: 171 EDGFTPLAVALQQGHDQVVSLLLENDTK---GKVRLPALHIAARKDDTKAAALLLQNDNN 227

Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
            ++  + G  PLH+    G +  A LLL   A VD  +   + TPLHVA++ G+  +  L
Sbjct: 228 ADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVD-FTARNDITPLHVASKRGNANMVKL 286

Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318
           LL RGA  DA+  +G TPL        + + +                      AT    
Sbjct: 287 LLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDH 346

Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378
           L    LLL      D    D    LH+A   GH  V ++LL    + N     G TPLH 
Sbjct: 347 LNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI 406

Query: 379 ALQGPAAALAQSPEHVVRALLNHGA 403
           A +       ++   V+  LL HGA
Sbjct: 407 ACK-------KNRIKVMELLLKHGA 424



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 56/179 (31%), Positives = 82/179 (45%), Gaps = 15/179 (8%)

Query: 182 RRRARPDSAPGGRTALH-EACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240
           R+R+R         A +  A  AGH       +  G D NI +Q+G   LHL    G +E
Sbjct: 29  RKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88

Query: 241 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 300
               LL+  A VD  + ++  T LH+A+  G  E+  +L+  GA  +A++  G+TPL  A
Sbjct: 89  VVSELLQREANVDA-ATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMA 147

Query: 301 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 359
                             L++   LL  GA    A +D   PL +A ++GH  VV LLL
Sbjct: 148 AQ-------------ENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL 193



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 47/147 (31%), Positives = 73/147 (49%), Gaps = 2/147 (1%)

Query: 165 LHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIAD 223
           +H+AA  GH +++ LLL R A  + S   G T LH A          VL+  GA  +   
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 727

Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRG 283
           + G  PLH+    G ++    LL+  A+V+ +++    TPLH AA+ GH  + ++LL+  
Sbjct: 728 KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGY-TPLHQAAQQGHTHIINVLLQNN 786

Query: 284 ACPDARNAEGWTPLLAACDVRCQSITD 310
           A P+     G T L  A  +   S+ D
Sbjct: 787 ASPNELTVNGNTALGIARRLGYISVVD 813



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 23/146 (15%)

Query: 264 LHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCS 323
           LH+A++ GHVE+   LL+R A  DA   +G T L  A             + A   ++  
Sbjct: 78  LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIA-------------SLAGQAEVVK 124

Query: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 383
           +L++ GA+ +A  Q+   PL++A +  H  VV+ LL  G S +     G TPL       
Sbjct: 125 VLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPL------- 177

Query: 384 AAALAQSPEHVVRALLNH---GAVRV 406
           A AL Q  + VV  LL +   G VR+
Sbjct: 178 AVALQQGHDQVVSLLLENDTKGKVRL 203



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 34/127 (26%), Positives = 60/127 (47%), Gaps = 2/127 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLHV    G+ +++  LL+  A+ ++    G T LH+A   GHT  ++VLL   A PN 
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV-ELADLLL 280
              +G   L + R  G +   + L          +   E+  ++V   +  V +++D  +
Sbjct: 792 LTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEV 851

Query: 281 RRGACPD 287
           R+   P+
Sbjct: 852 RKANAPE 858



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 41/137 (29%), Positives = 63/137 (45%), Gaps = 20/137 (14%)

Query: 267 AARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLL 326
           AAR GH+E A   ++ G   +  N  G   L  A             +    +++ S LL
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLA-------------SKEGHVEVVSELL 94

Query: 327 SAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAA 386
              A+ DAA +     LH+A   G A VV++L++ G + N     G TPL+ A Q     
Sbjct: 95  QREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQ----- 149

Query: 387 LAQSPEHVVRALLNHGA 403
             ++   VV+ LL++GA
Sbjct: 150 --ENHLEVVKFLLDNGA 164


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  115 bits (289), Expect = 7e-26
 Identities = 82/226 (36%), Positives = 109/226 (48%), Gaps = 17/226 (7%)

Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAG 216
           E E  TPLH+AA      V RLL+ R+A P+     G+T LH A   GH + V +L   G
Sbjct: 458 EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG 517

Query: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276
           A+ +   ++ + PLHL    G +   + LL+ GA  D   ++    PLH AA  G   + 
Sbjct: 518 AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDAL-DQSGYGPLHTAAARGKYLIC 576

Query: 277 DLLLRRGACPDARNAEGWTPL-LAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAA 335
            +LLR GA  +    +GWTPL LAA                  L++  LL  + A+  A 
Sbjct: 577 KMLLRYGASLELPTHQGWTPLHLAAYKGH--------------LEIIHLLAESHANMGAL 622

Query: 336 DQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
                 PLHLA R G  AVV  LL CG   N  +  G TPLH A+Q
Sbjct: 623 GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQ 668



 Score =  114 bits (284), Expect = 3e-25
 Identities = 88/246 (35%), Positives = 112/246 (45%), Gaps = 22/246 (8%)

Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGA 217
           E   TPLH   ++G  E +RLLL      D     G T L  A          +LL  GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277
           D N  D+DG  PLH     G    A LLL  GA VD + E E  TPLH+AA+     +A 
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQ-EREGWTPLHLAAQNNFENVAR 478

Query: 278 LLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQ 337
           LL+ R A P+   AEG TPL  A      S             L  LL S GA+ DA  +
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVS-------------LVKLLTSQGAELDAQQR 525

Query: 338 DKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRA 397
           + + PLHLA  RG    ++ LL  G   + +D  G+ PLH        A A+    + + 
Sbjct: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLH-------TAAARGKYLICKM 578

Query: 398 LLNHGA 403
           LL +GA
Sbjct: 579 LLRYGA 584



 Score =  112 bits (280), Expect = 7e-25
 Identities = 84/233 (36%), Positives = 112/233 (48%), Gaps = 16/233 (6%)

Query: 157 YEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGG-RTALHEACAAGHTACVHVLLVA 215
           +E E  TPLHVAA  GH  +++LL  + A  D+     RT LH A   G    +  LL +
Sbjct: 490 HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS 549

Query: 216 GADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVEL 275
           GA P+  DQ G  PLH     G     ++LLR+GA ++     +  TPLH+AA  GH+E+
Sbjct: 550 GAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLE-LPTHQGWTPLHLAAYKGHLEI 608

Query: 276 ADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAA 335
             LL    A   A  A  WTPL  A     +++  A             LL  GAD +AA
Sbjct: 609 IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA-------------LLQCGADPNAA 655

Query: 336 DQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH-CALQGPAAAL 387
           +Q    PLHLA +R     V  LL    + +  +  G TP H  AL+G  A L
Sbjct: 656 EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAIL 708



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 77/218 (35%), Positives = 96/218 (44%), Gaps = 15/218 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPL +AA     ++  LLL   A  +     G   LH A   G      +LL  GA  + 
Sbjct: 397 TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDA 456

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
            +++G  PLHL         A LL+   A      E E +TPLHVAA  GHV L  LL  
Sbjct: 457 QEREGWTPLHLAAQNNFENVARLLVSRQAD-PNLHEAEGKTPLHVAAYFGHVSLVKLLTS 515

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           +GA  DA+     TPL  A           E    R +Q    LL +GA  DA DQ    
Sbjct: 516 QGAELDAQQRNLRTPLHLA----------VERGKVRAIQ---HLLKSGAVPDALDQSGYG 562

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           PLH A  RG   + ++LL  G S     + G TPLH A
Sbjct: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 56/147 (38%), Positives = 71/147 (48%), Gaps = 2/147 (1%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+AA +GH E++ LL    A   +      T LH A   G  A V  LL  GADPN 
Sbjct: 595 TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
           A+Q G  PLHL     T      LL   A V  R+ +   TP H+AA  G+  +  +L+ 
Sbjct: 655 AEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN-KVGWTPAHLAALKGNTAILKVLVE 713

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSI 308
            GA  D ++    TPL  A   R Q I
Sbjct: 714 AGAQLDVQDGVSCTPLQLALRSRKQGI 740


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  110 bits (274), Expect = 4e-24
 Identities = 85/254 (33%), Positives = 114/254 (44%), Gaps = 23/254 (9%)

Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPN 220
           ++PLH AA  G  +V+  LL+  A   +   GG   LH AC+ GH   V +LL  GADPN
Sbjct: 217 SSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPN 276

Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGA-----RVDGRSEEEEETPLHVAARLGHVEL 275
             D     PLH     G ++   +LL+ GA       DG+S  +   P   A   G  + 
Sbjct: 277 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK 336

Query: 276 ADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC------LQLCSLLLSAG 329
            +LL        + N E    LL   +V C +    ++T          +++  LLL  G
Sbjct: 337 DELL----EAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHG 392

Query: 330 ADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
           AD  A D+    PLH AC  GH  V ELLL  G   N MD    TPLH        A ++
Sbjct: 393 ADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLH-------EAASK 445

Query: 390 SPEHVVRALLNHGA 403
           +   V   LL+HGA
Sbjct: 446 NRVEVCSLLLSHGA 459



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 76/252 (30%), Positives = 103/252 (40%), Gaps = 19/252 (7%)

Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPN 220
           +TPLH AA      V+  LL   A   +   GG   LH AC+ GH     +L+  GA  N
Sbjct: 685 STPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVN 744

Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 280
           +AD     PLH     G  E  +LLL+ GA    +   +  TPL +    G  ++ DLL 
Sbjct: 745 VADLWKFTPLHEAAAKGKYEICKLLLKHGADPT-KKNRDGNTPLDLVKE-GDTDIQDLLR 802

Query: 281 RRGACPDARNAEGWTPLLAAC---DVRCQSITDAEATTARC------LQLCSLLLSAGAD 331
              A  DA        +   C   ++ C+      +T          L++   LL  GAD
Sbjct: 803 GDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGAD 862

Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391
            +A D+    PLH A   GH  +  LL+      N  D    TPLH A Q       +  
Sbjct: 863 VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQ-------KGR 915

Query: 392 EHVVRALLNHGA 403
             +   LL HGA
Sbjct: 916 TQLCALLLAHGA 927



 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 74/252 (29%), Positives = 107/252 (42%), Gaps = 40/252 (15%)

Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 217
           ++  TPLHVAA R H +V+ +L +  A+ ++    G+TALH A  AGH     +LL  G+
Sbjct: 556 KDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGS 615

Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277
           DP+I    G     +       E  + +L             E TP+  +         D
Sbjct: 616 DPSIISLQGFTAAQMGN-----EAVQQIL------------SESTPIRTS---------D 649

Query: 278 LLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC------LQLCSLLLSAGAD 331
           +  R      A + E    L ++ +V C+ +    +T          + +   LL  GAD
Sbjct: 650 VDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGAD 709

Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391
             A D+    PLH AC  GH  V ELL+  G S N  D    TPLH        A A+  
Sbjct: 710 VHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLH-------EAAAKGK 762

Query: 392 EHVVRALLNHGA 403
             + + LL HGA
Sbjct: 763 YEICKLLLKHGA 774



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 77/254 (30%), Positives = 109/254 (42%), Gaps = 39/254 (15%)

Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNIA 222
           PLH A S GH EV  LL+R  A  + A   + T LHEA A G      +LL  GADP   
Sbjct: 720 PLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKK 779

Query: 223 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGR---------------------SEEEEE 261
           ++DG  PL L +  G  +  +LL    A +D                       ++    
Sbjct: 780 NRDGNTPLDLVK-EGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNS 838

Query: 262 TPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQL 321
           TPLH+AA   ++E+A+ LL  GA  +A++  G  PL               A +   + +
Sbjct: 839 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPL-------------HNAASYGHVDI 885

Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
            +LL+      +A D+    PLH A ++G   +  LLL+ G      +  G TPL  A  
Sbjct: 886 AALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945

Query: 382 GPAAAL---AQSPE 392
               AL   A  PE
Sbjct: 946 DDIRALLIDAMPPE 959



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 88/282 (31%), Positives = 113/282 (40%), Gaps = 54/282 (19%)

Query: 168 AASRGHTEVLRLLLRRRARPDSAPGGR--TALHEACAAGHTACVHVLLVAGADPNIADQD 225
           AA  G+ E L  LL        A  GR  T LH A        V +LL  GAD +  D+ 
Sbjct: 342 AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKG 401

Query: 226 GKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGAC 285
           G  PLH     G  E  ELLL+ GA V+   +  + TPLH AA    VE+  LLL  GA 
Sbjct: 402 GLVPLHNACSYGHYEVTELLLKHGACVNAM-DLWQFTPLHEAASKNRVEVCSLLLSHGAD 460

Query: 286 PDARNAEGW-------TP---------------LLAACDVRCQSI-------------TD 310
           P   N  G        TP               L AA +     +               
Sbjct: 461 PTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQ 520

Query: 311 AEATTARCL---------QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSC 361
           +  T   C          Q+  LLL  GA+ +  ++D   PLH+A  R H  V+E+L   
Sbjct: 521 SHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKH 580

Query: 362 GVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
           G   N +D  G T LH       AALA   +   R LL++G+
Sbjct: 581 GAKMNALDTLGQTALH------RAALAGHLQ-TCRLLLSYGS 615



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 44/128 (34%), Positives = 57/128 (44%), Gaps = 13/128 (10%)

Query: 260 EETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCL 319
           + +PLH AA  G  ++ + LL+ GA   AR+  G  PL  AC     S   AE       
Sbjct: 216 KSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNAC-----SFGHAE------- 263

Query: 320 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
            + SLLL  GAD +A D     PLH A  +G   V  +LL  G   N  +  G + L  A
Sbjct: 264 -VVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA 322

Query: 380 LQGPAAAL 387
                A L
Sbjct: 323 DPSAKAVL 330



 Score = 35.8 bits (81), Expect = 0.087
 Identities = 22/56 (39%), Positives = 27/56 (48%)

Query: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           L+ +A  +A      K  PLH A   G   VVE LL  G + +  D GG  PLH A
Sbjct: 201 LVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNA 256


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  110 bits (274), Expect = 4e-24
 Identities = 82/242 (33%), Positives = 116/242 (47%), Gaps = 21/242 (8%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPL  AA+ GH ++++LLL  +A  ++    G TAL  ACA G+   V VLL +GA    
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
            +++G  PL      G +E A LLL  GA ++  S E +E+ L +A   GH+E+   LL 
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
            GA  + +  E  T L+ AC        D     AR      LLL +GA  +      + 
Sbjct: 423 AGADQEHKTDEMHTALMEAC-------MDGHVEVAR------LLLDSGAQVNMPADSFES 469

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
           PL LA   GH  +  LL+  G S   ++  G+TPL         A  +  E +V  LL  
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPL-------MEAAREGHEEMVALLLGQ 522

Query: 402 GA 403
           GA
Sbjct: 523 GA 524



 Score = 93.2 bits (230), Expect = 5e-19
 Identities = 86/264 (32%), Positives = 116/264 (43%), Gaps = 26/264 (9%)

Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGA 217
           +E+ T L  A   GH EV RLLL   A+ +  A    + L  A   GH     +L+  GA
Sbjct: 432 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491

Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277
                + +G  PL      G  E   LLL  GA ++ ++EE +ET L +A   G +E+AD
Sbjct: 492 SLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVAD 551

Query: 278 LLLRRGA-------CPDARNA-EGWTPLL-----AACDVRCQSITDAEATTARC----LQ 320
            L++ GA        P    A EG   L+     A  +V   + T   A T  C      
Sbjct: 552 FLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTD 611

Query: 321 LCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSAN-TMDYGGHTPLHCA 379
           +  +LL AGAD +   +  + PL  A R GH   V+ L+S G + N T     HT L  A
Sbjct: 612 VADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671

Query: 380 LQGPAAALAQSPEHVVRALLNHGA 403
             G   A       VV  LL HGA
Sbjct: 672 CAGGHLA-------VVELLLAHGA 688



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 63/174 (36%), Positives = 86/174 (49%), Gaps = 15/174 (8%)

Query: 195  TALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDG 254
            TAL  ACA GH   V  LL  GA     D+ G  PL L    G +   E+LL  GA ++ 
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 255  RSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT 314
            +SE  ++TPL +A   G  E+ +LLL RGA  + RN   +TPL             + A 
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL-------------SLAA 1191

Query: 315  TARCLQLCSLLLSAGADADAADQDKQ--RPLHLACRRGHAAVVELLLSCGVSAN 366
            +   + +  +LL+AGA+ ++    K    PL LA   GH A V+LLL  G   N
Sbjct: 1192 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 1245



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 71/200 (35%), Positives = 94/200 (47%), Gaps = 16/200 (8%)

Query: 163  TPLHVAASRGHTEVLRLLLRRRARPDSA--PGGRTALHEACAAGHTACVHVLLVAGADPN 220
            +PL +AA  GHT  ++LLL   +  ++       TAL  AC  G T  V +LL   A+  
Sbjct: 1220 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1279

Query: 221  IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS-EEEEETPLHVAARLGHVELADLL 279
               + G  PL      G  E   +LL  GA V+        +T L +AA  GH +  +LL
Sbjct: 1280 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1339

Query: 280  LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 339
            + RGA  D RN +G TPL  A +                L +  LL+ AGAD DAAD  K
Sbjct: 1340 IGRGAHIDVRNKKGNTPLWLAAN-------------GGHLDVVQLLVQAGADVDAADNRK 1386

Query: 340  QRPLHLACRRGHAAVVELLL 359
              PL  A R+GH  VV  L+
Sbjct: 1387 ITPLMAAFRKGHVKVVRYLV 1406



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 93/274 (33%), Positives = 125/274 (45%), Gaps = 41/274 (14%)

Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 217
           +   +PL +AA  GH E+  LL+ R A  +     G T L EA   GH   V +LL  GA
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524

Query: 218 DPNIADQDGKRP-LHLCRGPGTLECAELLLRFGARVD-GRSEEEEETPLHVAARLGHVEL 275
           + N   ++ +   L L    G LE A+ L++ GA ++ G S     TPL  AA+ GH+EL
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS-----TPLMEAAQEGHLEL 579

Query: 276 ADLLLRRGACPDARNAEGWTPLLAAC--------DVRCQSITDAEATT----------AR 317
              LL  GA   A  A G T L  AC        DV  Q+  D E  +          AR
Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639

Query: 318 CLQLCSL--LLSAGADADAADQDKQRP-LHLACRRGHAAVVELLLSCGV-------SANT 367
              +C++  L+S GA+ +    +     L LAC  GH AVVELLL+ G          +T
Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699

Query: 368 M----DYGGHTPLHC-ALQGPAAALAQSPEHVVR 396
           M      GGHT + C  L  P   L+  P  V +
Sbjct: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQ 733



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 75/249 (30%), Positives = 103/249 (41%), Gaps = 25/249 (10%)

Query: 158  EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAG 216
            E    TPL +A S G  EV+ LLL R A  +       T L  A + G+   + +LL AG
Sbjct: 1147 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1206

Query: 217  ADPN--IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 274
            A+ N     + G  PL L    G     +LLL  G+ ++ + E    T L +A   G  E
Sbjct: 1207 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1266

Query: 275  LADLLLRRGACPDARNAEGWTPLLAAC----------------DVRCQSITDAEATTARC 318
            +  LLL R A  + R   G TPL+ A                 DV    +  +  T    
Sbjct: 1267 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1326

Query: 319  L------QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGG 372
                   + C LL+  GA  D  ++    PL LA   GH  VV+LL+  G   +  D   
Sbjct: 1327 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1386

Query: 373  HTPLHCALQ 381
             TPL  A +
Sbjct: 1387 ITPLMAAFR 1395



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 90/310 (29%), Positives = 128/310 (41%), Gaps = 37/310 (11%)

Query: 124 TGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEE-------ELTTPLHVAASRGHTEV 176
           +G A  +   T DPE        + A  +  L+  +       E+   L  + S    E 
Sbjct: 156 SGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEA 215

Query: 177 LRLLLRRRARPDSAPG--GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCR 234
              L R RA   +  G     +L EAC+ G    V  LL+ G   N   ++G+  L L  
Sbjct: 216 AAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLAC 275

Query: 235 GPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGW 294
             G  E A++LL   A V+ R  + + TPL  AA  GHV++  LLL   A  +A+++ G 
Sbjct: 276 SAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGN 335

Query: 295 TPLLAAC-----DV------RCQSITD---------AEATTARCLQLCSLLLSAGADADA 334
           T L  AC     DV         SI D          EA +A  +++  LLL  GA  + 
Sbjct: 336 TALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINT 395

Query: 335 -ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEH 393
            +++ K+  L LAC +GH  +V  LL  G          HT L         A       
Sbjct: 396 HSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL-------MEACMDGHVE 448

Query: 394 VVRALLNHGA 403
           V R LL+ GA
Sbjct: 449 VARLLLDSGA 458



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 52/153 (33%), Positives = 77/153 (50%), Gaps = 21/153 (13%)

Query: 252  VDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA 311
            +D ++E   +T L +A   GH EL   LL RGA  + R+ +G+TPL+             
Sbjct: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLIL------------ 1122

Query: 312  EATTARCLQLCSLLLSAGADADA-ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 370
             A TA  + +  +LL  GAD +A +++ K  PL LAC  G   VVELLL+ G +    + 
Sbjct: 1123 -AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 1181

Query: 371  GGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
              +TPL  A  G          ++++ LLN GA
Sbjct: 1182 SDYTPLSLAASGGYV-------NIIKILLNAGA 1207



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 58/186 (31%), Positives = 87/186 (46%), Gaps = 15/186 (8%)

Query: 163  TPLHVAASRGHTEVLRLLLRRRARPDSAP---GGRTALHEACAAGHTACVHVLLVAGADP 219
            TPL  AAS G+ EV R+LL + A  ++ P      TAL  A   GH     +L+  GA  
Sbjct: 1287 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI 1346

Query: 220  NIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279
            ++ ++ G  PL L    G L+  +LL++ GA VD  ++  + TPL  A R GHV++   L
Sbjct: 1347 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA-ADNRKITPLMAAFRKGHVKVVRYL 1405

Query: 280  LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 339
            ++              P  + C     +ITD E    +C  LC   +    D  AA+ +K
Sbjct: 1406 VKE---------VNQFPSDSECMRYIATITDKE-MLKKC-HLCMESIVQAKDRQAAEANK 1454

Query: 340  QRPLHL 345
               + L
Sbjct: 1455 NASILL 1460


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
           sapiens]
          Length = 2352

 Score =  110 bits (274), Expect = 4e-24
 Identities = 82/242 (33%), Positives = 116/242 (47%), Gaps = 21/242 (8%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPL  AA+ GH ++++LLL  +A  ++    G TAL  ACA G+   V VLL +GA    
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
            +++G  PL      G +E A LLL  GA ++  S E +E+ L +A   GH+E+   LL 
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
            GA  + +  E  T L+ AC        D     AR      LLL +GA  +      + 
Sbjct: 423 AGADQEHKTDEMHTALMEAC-------MDGHVEVAR------LLLDSGAQVNMPADSFES 469

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
           PL LA   GH  +  LL+  G S   ++  G+TPL         A  +  E +V  LL  
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPL-------MEAAREGHEEMVALLLGQ 522

Query: 402 GA 403
           GA
Sbjct: 523 GA 524



 Score = 93.2 bits (230), Expect = 5e-19
 Identities = 86/264 (32%), Positives = 116/264 (43%), Gaps = 26/264 (9%)

Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGA 217
           +E+ T L  A   GH EV RLLL   A+ +  A    + L  A   GH     +L+  GA
Sbjct: 432 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491

Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277
                + +G  PL      G  E   LLL  GA ++ ++EE +ET L +A   G +E+AD
Sbjct: 492 SLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVAD 551

Query: 278 LLLRRGA-------CPDARNA-EGWTPLL-----AACDVRCQSITDAEATTARC----LQ 320
            L++ GA        P    A EG   L+     A  +V   + T   A T  C      
Sbjct: 552 FLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTD 611

Query: 321 LCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSAN-TMDYGGHTPLHCA 379
           +  +LL AGAD +   +  + PL  A R GH   V+ L+S G + N T     HT L  A
Sbjct: 612 VADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671

Query: 380 LQGPAAALAQSPEHVVRALLNHGA 403
             G   A       VV  LL HGA
Sbjct: 672 CAGGHLA-------VVELLLAHGA 688



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 63/174 (36%), Positives = 86/174 (49%), Gaps = 15/174 (8%)

Query: 195 TALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDG 254
           TAL  ACA GH   V  LL  GA     D+ G  PL L    G +   E+LL  GA ++ 
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893

Query: 255 RSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT 314
           +SE  ++TPL +A   G  E+ +LLL RGA  + RN   +TPL             + A 
Sbjct: 894 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL-------------SLAA 940

Query: 315 TARCLQLCSLLLSAGADADAADQDKQ--RPLHLACRRGHAAVVELLLSCGVSAN 366
           +   + +  +LL+AGA+ ++    K    PL LA   GH A V+LLL  G   N
Sbjct: 941 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 994



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 71/200 (35%), Positives = 94/200 (47%), Gaps = 16/200 (8%)

Query: 163  TPLHVAASRGHTEVLRLLLRRRARPDSA--PGGRTALHEACAAGHTACVHVLLVAGADPN 220
            +PL +AA  GHT  ++LLL   +  ++       TAL  AC  G T  V +LL   A+  
Sbjct: 969  SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1028

Query: 221  IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS-EEEEETPLHVAARLGHVELADLL 279
               + G  PL      G  E   +LL  GA V+        +T L +AA  GH +  +LL
Sbjct: 1029 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1088

Query: 280  LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 339
            + RGA  D RN +G TPL  A +                L +  LL+ AGAD DAAD  K
Sbjct: 1089 IGRGAHIDVRNKKGNTPLWLAAN-------------GGHLDVVQLLVQAGADVDAADNRK 1135

Query: 340  QRPLHLACRRGHAAVVELLL 359
              PL  A R+GH  VV  L+
Sbjct: 1136 ITPLMAAFRKGHVKVVRYLV 1155



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 93/274 (33%), Positives = 125/274 (45%), Gaps = 41/274 (14%)

Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 217
           +   +PL +AA  GH E+  LL+ R A  +     G T L EA   GH   V +LL  GA
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524

Query: 218 DPNIADQDGKRP-LHLCRGPGTLECAELLLRFGARVD-GRSEEEEETPLHVAARLGHVEL 275
           + N   ++ +   L L    G LE A+ L++ GA ++ G S     TPL  AA+ GH+EL
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS-----TPLMEAAQEGHLEL 579

Query: 276 ADLLLRRGACPDARNAEGWTPLLAAC--------DVRCQSITDAEATT----------AR 317
              LL  GA   A  A G T L  AC        DV  Q+  D E  +          AR
Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639

Query: 318 CLQLCSL--LLSAGADADAADQDKQRP-LHLACRRGHAAVVELLLSCGV-------SANT 367
              +C++  L+S GA+ +    +     L LAC  GH AVVELLL+ G          +T
Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699

Query: 368 M----DYGGHTPLHC-ALQGPAAALAQSPEHVVR 396
           M      GGHT + C  L  P   L+  P  V +
Sbjct: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQ 733



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 75/249 (30%), Positives = 103/249 (41%), Gaps = 25/249 (10%)

Query: 158  EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAG 216
            E    TPL +A S G  EV+ LLL R A  +       T L  A + G+   + +LL AG
Sbjct: 896  ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 955

Query: 217  ADPN--IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 274
            A+ N     + G  PL L    G     +LLL  G+ ++ + E    T L +A   G  E
Sbjct: 956  AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1015

Query: 275  LADLLLRRGACPDARNAEGWTPLLAAC----------------DVRCQSITDAEATTARC 318
            +  LLL R A  + R   G TPL+ A                 DV    +  +  T    
Sbjct: 1016 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1075

Query: 319  L------QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGG 372
                   + C LL+  GA  D  ++    PL LA   GH  VV+LL+  G   +  D   
Sbjct: 1076 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1135

Query: 373  HTPLHCALQ 381
             TPL  A +
Sbjct: 1136 ITPLMAAFR 1144



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 90/310 (29%), Positives = 128/310 (41%), Gaps = 37/310 (11%)

Query: 124 TGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEE-------ELTTPLHVAASRGHTEV 176
           +G A  +   T DPE        + A  +  L+  +       E+   L  + S    E 
Sbjct: 156 SGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEA 215

Query: 177 LRLLLRRRARPDSAPG--GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCR 234
              L R RA   +  G     +L EAC+ G    V  LL+ G   N   ++G+  L L  
Sbjct: 216 AAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLAC 275

Query: 235 GPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGW 294
             G  E A++LL   A V+ R  + + TPL  AA  GHV++  LLL   A  +A+++ G 
Sbjct: 276 SAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGN 335

Query: 295 TPLLAAC-----DV------RCQSITD---------AEATTARCLQLCSLLLSAGADADA 334
           T L  AC     DV         SI D          EA +A  +++  LLL  GA  + 
Sbjct: 336 TALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINT 395

Query: 335 -ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEH 393
            +++ K+  L LAC +GH  +V  LL  G          HT L         A       
Sbjct: 396 HSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL-------MEACMDGHVE 448

Query: 394 VVRALLNHGA 403
           V R LL+ GA
Sbjct: 449 VARLLLDSGA 458



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 52/153 (33%), Positives = 77/153 (50%), Gaps = 21/153 (13%)

Query: 252 VDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA 311
           +D ++E   +T L +A   GH EL   LL RGA  + R+ +G+TPL+             
Sbjct: 824 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLIL------------ 871

Query: 312 EATTARCLQLCSLLLSAGADADA-ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 370
            A TA  + +  +LL  GAD +A +++ K  PL LAC  G   VVELLL+ G +    + 
Sbjct: 872 -AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 930

Query: 371 GGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
             +TPL  A  G          ++++ LLN GA
Sbjct: 931 SDYTPLSLAASGGYV-------NIIKILLNAGA 956



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 58/186 (31%), Positives = 87/186 (46%), Gaps = 15/186 (8%)

Query: 163  TPLHVAASRGHTEVLRLLLRRRARPDSAP---GGRTALHEACAAGHTACVHVLLVAGADP 219
            TPL  AAS G+ EV R+LL + A  ++ P      TAL  A   GH     +L+  GA  
Sbjct: 1036 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI 1095

Query: 220  NIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279
            ++ ++ G  PL L    G L+  +LL++ GA VD  ++  + TPL  A R GHV++   L
Sbjct: 1096 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA-ADNRKITPLMAAFRKGHVKVVRYL 1154

Query: 280  LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 339
            ++              P  + C     +ITD E    +C  LC   +    D  AA+ +K
Sbjct: 1155 VKE---------VNQFPSDSECMRYIATITDKE-MLKKC-HLCMESIVQAKDRQAAEANK 1203

Query: 340  QRPLHL 345
               + L
Sbjct: 1204 NASILL 1209


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  109 bits (273), Expect = 5e-24
 Identities = 84/254 (33%), Positives = 115/254 (45%), Gaps = 23/254 (9%)

Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPN 220
           +TPLH AA  G  +V+  LL+  A   +   GG   LH AC+ GH   V++LL  GADPN
Sbjct: 59  STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118

Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGAR-----VDGRSEEEEETPLHVAARLGHVEL 275
             D     PLH     G ++   +LL+ GA       DGR+  +   P   A   G  + 
Sbjct: 119 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKK 178

Query: 276 ADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC------LQLCSLLLSAG 329
            +LL        + N E    LL   +V C +    ++T          +++  LLL  G
Sbjct: 179 DELL----ESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHG 234

Query: 330 ADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
           AD  A D+    PLH AC  GH  V ELL+  G   N MD    TPLH        A ++
Sbjct: 235 ADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLH-------EAASK 287

Query: 390 SPEHVVRALLNHGA 403
           +   V   LL++GA
Sbjct: 288 NRVEVCSLLLSYGA 301



 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 79/248 (31%), Positives = 111/248 (44%), Gaps = 32/248 (12%)

Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 217
           +E  TPLHVA+ + H +V+ ++++  A+ ++    G+T+LH A   GH     +LL  G 
Sbjct: 398 KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGC 457

Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277
           DPNI    G   L +       E  + LL+ G  + G SE + +  L  AA+ G VE   
Sbjct: 458 DPNIISLQGFTALQMGN-----ENVQQLLQEGISL-GNSEADRQ--LLEAAKAGDVETVK 509

Query: 278 LL--LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAA 335
            L  ++   C D    +  TPL  A      S+ +              LL  GAD  A 
Sbjct: 510 KLCTVQSVNCRDIEGRQS-TPLHFAAGYNRVSVVE-------------YLLQHGADVHAK 555

Query: 336 DQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVV 395
           D+    PLH AC  GH  V ELL+  G   N  D    TPLH        A A+    + 
Sbjct: 556 DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLH-------EAAAKGKYEIC 608

Query: 396 RALLNHGA 403
           + LL HGA
Sbjct: 609 KLLLQHGA 616



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 80/256 (31%), Positives = 108/256 (42%), Gaps = 19/256 (7%)

Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAG 216
           E   +TPLH AA      V+  LL+  A   +   GG   LH AC+ GH     +L+  G
Sbjct: 523 EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 582

Query: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276
           A  N+AD     PLH     G  E  +LLL+ GA    +   +  TPL +  + G  ++ 
Sbjct: 583 AVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPT-KKNRDGNTPLDLV-KDGDTDIQ 640

Query: 277 DLLLRRGACPDA--RNAEGWTPLLAACD-VRCQSITDAEATTARC------LQLCSLLLS 327
           DLL    A  DA  +        L++ D V C+      +T          L++   LL 
Sbjct: 641 DLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQ 700

Query: 328 AGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAAL 387
            GAD +A D+    PLH A   GH  V  LL+      N  D    TPLH A Q      
Sbjct: 701 HGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQ------ 754

Query: 388 AQSPEHVVRALLNHGA 403
            +    +   LL HGA
Sbjct: 755 -KGRTQLCALLLAHGA 769



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 73/246 (29%), Positives = 108/246 (43%), Gaps = 36/246 (14%)

Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNIA 222
           PLH A S GH EV  LL++  A  + A   + T LHEA A G      +LL  GADP   
Sbjct: 562 PLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKK 621

Query: 223 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGR---------------------SEEEEE 261
           ++DG  PL L +  G  +  +LL    A +D                       ++    
Sbjct: 622 NRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHS 680

Query: 262 TPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQL 321
           TPLH+AA   ++E+A+ LL+ GA  +A++  G  PL               A +   + +
Sbjct: 681 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPL-------------HNAASYGHVDV 727

Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
            +LL+   A  +A D+    PLH A ++G   +  LLL+ G      +  G TPL     
Sbjct: 728 AALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787

Query: 382 GPAAAL 387
              +AL
Sbjct: 788 DDVSAL 793



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 75/270 (27%), Positives = 105/270 (38%), Gaps = 46/270 (17%)

Query: 155 LTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLL 213
           LT E +    L  A S    +++ LL        ++ G + T LH A        V +LL
Sbjct: 172 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLL 231

Query: 214 VAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV 273
             GAD +  D+    PLH     G  E  ELL++ GA V+   +  + TPLH AA    V
Sbjct: 232 QHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAM-DLWQFTPLHEAASKNRV 290

Query: 274 ELADLLLRRGACPDARNA----------------------EGWTPLLAACDVRCQSI--- 308
           E+  LLL  GA P   N                       +G + L AA +     I   
Sbjct: 291 EVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKH 350

Query: 309 ----------TDAEATTARCL---------QLCSLLLSAGADADAADQDKQRPLHLACRR 349
                          T   C          Q+C LLL  GA+ +   ++   PLH+A  +
Sbjct: 351 LSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEK 410

Query: 350 GHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
            H  VVE+++      N +D  G T LH A
Sbjct: 411 AHNDVVEVVVKHEAKVNALDNLGQTSLHRA 440



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 72/244 (29%), Positives = 99/244 (40%), Gaps = 61/244 (25%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARP--------------------------------DSA 190
           TPLH AA++G  E+ +LLL+  A P                                D+A
Sbjct: 594 TPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAA 653

Query: 191 PGG-----------------------RTALHEACAAGHTACVHVLLVAGADPNIADQDGK 227
             G                        T LH A    +      LL  GAD N  D+ G 
Sbjct: 654 KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL 713

Query: 228 RPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPD 287
            PLH     G ++ A LL+++ A V+  +++   TPLH AA+ G  +L  LLL  GA P 
Sbjct: 714 IPLHNAASYGHVDVAALLIKYNACVNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 772

Query: 288 ARNAEGWTPL-LAACDVRCQSITDAEATTA--RCL--QLCSLLLSAGADADAADQDKQRP 342
            +N EG TPL L + D     +T A   +A   C   Q+ + + S GA ADA       P
Sbjct: 773 LKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSP 832

Query: 343 LHLA 346
             L+
Sbjct: 833 SSLS 836


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  108 bits (271), Expect = 8e-24
 Identities = 76/219 (34%), Positives = 108/219 (49%), Gaps = 15/219 (6%)

Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPN 220
           T PL +AA  G+ ++L+LL++R +R D    GG  A++ A   GH   +  L       +
Sbjct: 380 TPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLD 439

Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 280
           + D+ G+  LH+    G  + A+LL  FG+      ++EEETPLH AA  G+  +A  L 
Sbjct: 440 VKDKSGEMALHVAARYGHADVAQLLCSFGSN-PNIQDKEEETPLHCAAWHGYYSVAKALC 498

Query: 281 RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 340
             G   + +N EG TPLL A       I +              L   GAD +A D+D  
Sbjct: 499 EAGCNVNIKNREGETPLLTASARGYHDIVEC-------------LAEHGADLNACDKDGH 545

Query: 341 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
             LHLA RR    V++ LLS G   +  D  G+TPLH A
Sbjct: 546 IALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVA 584



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 65/213 (30%), Positives = 97/213 (45%), Gaps = 15/213 (7%)

Query: 168 AASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDG 226
           AA  GH + L+ L   +   D     G  ALH A   GH     +L   G++PNI D++ 
Sbjct: 419 AARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE 478

Query: 227 KRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACP 286
           + PLH     G    A+ L   G  V+ ++  E ETPL  A+  G+ ++ + L   GA  
Sbjct: 479 ETPLHCAAWHGYYSVAKALCEAGCNVNIKN-REGETPLLTASARGYHDIVECLAEHGADL 537

Query: 287 DARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLA 346
           +A + +G   L  A   RCQ            +++   LLS G   D  D+    PLH+A
Sbjct: 538 NACDKDGHIALHLAVR-RCQ------------MEVIKTLLSQGCFVDYQDRHGNTPLHVA 584

Query: 347 CRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           C+ G+  +V  L     + +  +  G TPLH A
Sbjct: 585 CKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 61/202 (30%), Positives = 80/202 (39%), Gaps = 15/202 (7%)

Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAG 216
           ++E  TPLH AA  G+  V + L       +     G T L  A A G+   V  L   G
Sbjct: 475 DKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHG 534

Query: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276
           AD N  D+DG   LHL      +E  + LL  G  VD + +    TPLHVA + G++ + 
Sbjct: 535 ADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQ-DRHGNTPLHVACKDGNMPIV 593

Query: 277 DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 336
             L       D  N  G TPL  A +                L +   L   GA  +A  
Sbjct: 594 VALCEANCNLDISNKYGRTPLHLAAN-------------NGILDVVRYLCLMGASVEALT 640

Query: 337 QDKQRPLHLACRRGHAAVVELL 358
            D +    LA    H  V  LL
Sbjct: 641 TDGKTAEDLARSEQHEHVAGLL 662



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 39/118 (33%), Positives = 55/118 (46%), Gaps = 9/118 (7%)

Query: 165 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 223
           LH+A  R   EV++ LL +    D     G T LH AC  G+   V  L  A  + +I++
Sbjct: 548 LHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISN 607

Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARV-----DGRSEEE---EETPLHVAARLGHV 273
           + G+ PLHL    G L+    L   GA V     DG++ E+    E   HVA  L  +
Sbjct: 608 KYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARL 665


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  107 bits (266), Expect = 3e-23
 Identities = 84/269 (31%), Positives = 122/269 (45%), Gaps = 28/269 (10%)

Query: 156 TYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLV 214
           T + E  TPLHVAA  G  E++ LL+   AR ++      T LH A A+     V VL+ 
Sbjct: 11  TLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIK 70

Query: 215 AGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 274
             AD N  D++ + PLH+      ++CAE+++   + V+  S+    T LH AA  GHVE
Sbjct: 71  HSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV-SDRGGRTALHHAALNGHVE 129

Query: 275 LADLLLRRGACPDA-----RNAEGWTPLLAACDVRCQSITDAEATTARC----------- 318
           + +LLL +GA  +A     R A  W   +   DV    I      T +            
Sbjct: 130 MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAA 189

Query: 319 ----LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHT 374
               + +   LL+ G + D  +      LH+AC  G  AVV  L+  G + N  +  G T
Sbjct: 190 SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFT 249

Query: 375 PLHCALQGPAAALAQSPEHVVRALLNHGA 403
           PLH A      AL       +  L+N+GA
Sbjct: 250 PLHFAAASTHGALC------LELLVNNGA 272



 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 79/242 (32%), Positives = 113/242 (46%), Gaps = 29/242 (11%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLHVAA+    +   +++   +  + S  GGRTALH A   GH   V++LL  GA+ N 
Sbjct: 84  TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINA 143

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
            D+  +R LH     G L+   LL+  GA V  + +++  TPLH AA  G + +   LL 
Sbjct: 144 FDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK-DKKGYTPLHAAASNGQINVVKHLLN 202

Query: 282 RGACPDARNAEGWTPLLAAC----DVRCQSITD------------------AEATT--AR 317
            G   D  N  G T L  AC    D     + D                  A A+T  A 
Sbjct: 203 LGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL 262

Query: 318 CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377
           CL+   LL++ GAD +   +D + PLH+    G     + L+  G   + +D  G+TPLH
Sbjct: 263 CLE---LLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLH 319

Query: 378 CA 379
            A
Sbjct: 320 VA 321



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 93/297 (31%), Positives = 129/297 (43%), Gaps = 32/297 (10%)

Query: 98  GPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPE--RWRDFRFNIRALRLWSL 155
           G   A   A L G V  V+ +LA      A  + FD  D     W  +  ++  + L  +
Sbjct: 114 GGRTALHHAALNGHVEMVNLLLAKG----ANINAFDKKDRRALHWAAYMGHLDVVALL-I 168

Query: 156 TYEEELT-------TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTA 207
            +  E+T       TPLH AAS G   V++ LL      D     G TALH AC  G  A
Sbjct: 169 NHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDA 228

Query: 208 CVHVLLVAGADPNIADQDGKRPLHLCRGP--GTLECAELLLRFGARVDGRSEEEEETPLH 265
            V+ L+  GA+ N  + +G  PLH       G L C ELL+  GA V+ +S++ + +PLH
Sbjct: 229 VVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL-CLELLVNNGADVNIQSKDGK-SPLH 286

Query: 266 VAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLL 325
           + A  G    +  L++ G   D  + +G TPL  A     +              L + L
Sbjct: 287 MTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHEL-------------LINTL 333

Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 382
            ++GAD          PLHLA    H+     LLS G   +T D  G T LH A  G
Sbjct: 334 RTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAG 390



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 77/239 (32%), Positives = 106/239 (44%), Gaps = 20/239 (8%)

Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRAR--PDSAPGG-RTALHEACAAGHTACVHVLLV 214
           ++E    +H AA+ GH + L LLL R      +S  G  ++ LH A   GH   + VLL 
Sbjct: 504 DKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQ 563

Query: 215 AGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 274
           +  D +I D+ G+  L L    G  EC E L+  GA +  +    + TPLH +   GH  
Sbjct: 564 SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTL 623

Query: 275 LADLLLRRGACP---DARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331
              LLL     P   D ++A+G TPL+              A     +   SLLL   A+
Sbjct: 624 CLRLLLEIADNPEAVDVKDAKGQTPLML-------------AVAYGHIDAVSLLLEKEAN 670

Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH-CALQGPAAALAQ 389
            D  D      LH     GH   V++LL   VS    D  G TPLH  A +G A  L++
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSE 729



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 66/205 (32%), Positives = 97/205 (47%), Gaps = 28/205 (13%)

Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277
           D N  D + + PLH+    G  E  ELL+  GARV+ + +    TPLH A      E   
Sbjct: 8   DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAK-DNMWLTPLHRAVASRSEEAVQ 66

Query: 278 LLLRRGACPDARNAEGWTPLLAAC---DVRCQ----------SITDAEATTA-------R 317
           +L++  A  +AR+    TPL  A     V+C           +++D    TA        
Sbjct: 67  VLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNG 126

Query: 318 CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377
            +++ +LLL+ GA+ +A D+  +R LH A   GH  VV LL++ G      D  G+TPLH
Sbjct: 127 HVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLH 186

Query: 378 CALQGPAAALAQSPEHVVRALLNHG 402
                  AA +    +VV+ LLN G
Sbjct: 187 -------AAASNGQINVVKHLLNLG 204



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 77/269 (28%), Positives = 110/269 (40%), Gaps = 48/269 (17%)

Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIA 222
           PLH+AA   H++  R LL      D+    GRT LH A A G+  C+ +L  +GAD +  
Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409

Query: 223 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAAR---------LGHV 273
           D+ G+ PLH         C E L+  GA V+  +++   T LH AA          LG+ 
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILGNA 468

Query: 274 E-------------------LADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT 314
                                 + LL+  A P  R+ EG+  +  A          A   
Sbjct: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYA----------AAYG 518

Query: 315 TARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHT 374
             +CL+L     ++G +   +   K  PLHLA   GH   +E+LL   V  +  D  G T
Sbjct: 519 HRQCLELLLERTNSGFEESDSGATKS-PLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRT 577

Query: 375 PLHCALQGPAAALAQSPEHVVRALLNHGA 403
            L         A  +     V AL+N GA
Sbjct: 578 ALD-------LAAFKGHTECVEALINPGA 599



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 69/202 (34%), Positives = 90/202 (44%), Gaps = 18/202 (8%)

Query: 163 TPLHVAASRGH----TEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGAD 218
           TPLH AA+RGH    +E+L++ L           G T LH AC  G+  C+ VLL     
Sbjct: 713 TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCF 772

Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLL-RFGARVDGRSEEEEETPLHVAARLGHVELAD 277
                     PLH         CA LLL    + +    +++  TPL  AA   HVE   
Sbjct: 773 RKFIGNPFT-PLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQ 831

Query: 278 LLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQ 337
           LLLR  A  +A +  G T L+ A          AE   A  + +  L+ SA AD    D+
Sbjct: 832 LLLRHSAPVNAVDNSGKTALMMA----------AENGQAGAVDI--LVNSAQADLTVKDK 879

Query: 338 DKQRPLHLACRRGHAAVVELLL 359
           D   PLHLAC +GH     L+L
Sbjct: 880 DLNTPLHLACSKGHEKCALLIL 901



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 78/255 (30%), Positives = 104/255 (40%), Gaps = 32/255 (12%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP----GGRTALHEACAAGHTACVHVLLVAGAD 218
           TPLH +   GHT  LRLLL     P++       G+T L  A A GH   V +LL   A+
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670

Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV----E 274
            +  D  G   LH     G  EC ++LL     +  + +    TPLH AA  GH     E
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYAAARGHATWLSE 729

Query: 275 LADLLLRRGACPDARNAEGWTPLLAAC------------DVRC-QSITDAEATTARCLQL 321
           L  + L    C    N +G+TPL  AC            + +C +       T   C  +
Sbjct: 730 LLQMALSEEDCCFKDN-QGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAII 788

Query: 322 -----CSLLLSAGADADAAD--QDKQR-PLHLACRRGHAAVVELLLSCGVSANTMDYGGH 373
                C+ LL    D+       DK R PL  A    H   ++LLL      N +D  G 
Sbjct: 789 NDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK 848

Query: 374 TPLHCALQ-GPAAAL 387
           T L  A + G A A+
Sbjct: 849 TALMMAAENGQAGAV 863



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 27/80 (33%), Positives = 39/80 (48%), Gaps = 7/80 (8%)

Query: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 383
           +L+    D +  D +K+ PLH+A   G A ++ELL+  G   N  D    TPLH      
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLH------ 54

Query: 384 AAALAQSPEHVVRALLNHGA 403
             A+A   E  V+ L+ H A
Sbjct: 55  -RAVASRSEEAVQVLIKHSA 73



 Score = 29.3 bits (64), Expect = 8.1
 Identities = 11/24 (45%), Positives = 18/24 (75%)

Query: 158 EEELTTPLHVAASRGHTEVLRLLL 181
           +++L TPLH+A S+GH +   L+L
Sbjct: 878 DKDLNTPLHLACSKGHEKCALLIL 901


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  105 bits (262), Expect = 9e-23
 Identities = 84/242 (34%), Positives = 113/242 (46%), Gaps = 17/242 (7%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPL +AA +GHT+V+  L+   A  +     G TAL  A   GHT  V  LL AG   + 
Sbjct: 580 TPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDC 639

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
           AD D +  L      G  +    LL+ GA V+ +++ E  T L  AA +GH E+ + LL 
Sbjct: 640 ADADSRTALRAAAWGGHEDIVLNLLQHGAEVN-KADNEGRTALIAAAYMGHREIVEHLLD 698

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
            GA  +  + +G T L  A    C   +   A+        SLL+  GA+ D  D+D   
Sbjct: 699 HGAEVNHEDVDGRTALSVAA--LCVPASKGHASVV------SLLIDRGAEVDHCDKDGMT 750

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
           PL +A   GH  VV+LLL  G   +  D  G TPL        AA +     VV  LL  
Sbjct: 751 PLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPL-------LAAASMGHASVVNTLLFW 803

Query: 402 GA 403
           GA
Sbjct: 804 GA 805



 Score =  105 bits (261), Expect = 1e-22
 Identities = 90/246 (36%), Positives = 112/246 (45%), Gaps = 27/246 (10%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
           T L  AA  GHTEV+  LL    + D A    RTAL  A   GH   V  LL  GA+ N 
Sbjct: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARL-----GHVELA 276
           AD +G+  L      G  E  E LL  GA V+   + +  T L VAA       GH  + 
Sbjct: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVN-HEDVDGRTALSVAALCVPASKGHASVV 731

Query: 277 DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 336
            LL+ RGA  D  + +G TPLL A       + D             LLL  GAD D  D
Sbjct: 732 SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVD-------------LLLEGGADVDHTD 778

Query: 337 QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVR 396
            + + PL  A   GHA+VV  LL  G + +++D  G T L       + A AQ    VVR
Sbjct: 779 NNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL-------SIASAQGNVEVVR 831

Query: 397 ALLNHG 402
            LL+ G
Sbjct: 832 TLLDRG 837



 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 75/262 (28%), Positives = 119/262 (45%), Gaps = 25/262 (9%)

Query: 147  IRALRLWSL---TYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACA 202
            +  L  W     + + E  T L +A+++G+ EV+R LL R    +     G T LH A  
Sbjct: 797  VNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAF 856

Query: 203  AGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEET 262
             GH      L+  GA  N  D DG+ P  L    G  +C ++LL   + +D R  +    
Sbjct: 857  EGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNA 916

Query: 263  PLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLC 322
             L VAA  GH ++ +LL   GA  + ++A+G  P L    +  Q            L + 
Sbjct: 917  -LRVAALEGHRDIVELLFSHGADVNCKDADG-RPTLYILALENQ------------LTMA 962

Query: 323  SLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 382
               L  GA+ +A+D + +  LH++C +GH  +V++L++     N  D    + L      
Sbjct: 963  EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ----- 1017

Query: 383  PAAALAQSPEHVVRALLNHGAV 404
              +A  Q    VV+ L+ HGAV
Sbjct: 1018 --SAAWQGHVKVVQLLIEHGAV 1037



 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 69/216 (31%), Positives = 101/216 (46%), Gaps = 15/216 (6%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPL VAA  GH +V+ LLL   A  D     GRT L  A + GH + V+ LL  GA  + 
Sbjct: 750 TPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS 809

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
            D +G+  L +    G +E    LL  G   + R ++   TPLH+AA  GH  + + L+ 
Sbjct: 810 IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHR-DDAGWTPLHMAAFEGHRLICEALIE 868

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
           +GA  +  + +G  P + A          ++     C+Q   +LL   ++ D    D + 
Sbjct: 869 QGARTNEIDNDGRIPFILA----------SQEGHYDCVQ---ILLENKSNIDQRGYDGRN 915

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377
            L +A   GH  +VELL S G   N  D  G   L+
Sbjct: 916 ALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLY 951



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 71/246 (28%), Positives = 117/246 (47%), Gaps = 24/246 (9%)

Query: 164  PLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNIA 222
            P  +A+  GH + +++LL  ++  D     GR AL  A   GH   V +L   GAD N  
Sbjct: 883  PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 942

Query: 223  DQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR 282
            D DG+  L++      L  AE  L  GA V+  S+ E  T LHV+   GH+E+  +L+  
Sbjct: 943  DADGRPTLYILALENQLTMAEYFLENGANVEA-SDAEGRTALHVSCWQGHMEMVQVLIAY 1001

Query: 283  GACPDARNAEGWTPLLAAC---DVRCQSI----------TDAEATTARC-------LQLC 322
             A  +A + E  + L +A     V+   +          T  +  TA C       + + 
Sbjct: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVV 1061

Query: 323  SLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 382
             +LL  GAD + ADQ  +  + +A + GH+ +++LL   G  A++++    +P+H   Q 
Sbjct: 1062 QVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG--ASSLNGCSPSPVHTMEQK 1119

Query: 383  PAAALA 388
            P  +L+
Sbjct: 1120 PLQSLS 1125



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 47/147 (31%), Positives = 65/147 (44%), Gaps = 16/147 (10%)

Query: 236 PGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWT 295
           P   E  +LL++ GA V+    E++ T   V   L   +    LL  GA  +  ++ G T
Sbjct: 491 PKEQEVLQLLVKAGAHVNS---EDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRT 547

Query: 296 PLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVV 355
            L             A A  +  L + +LL+S GAD +  D     PL LA R+GH  VV
Sbjct: 548 LL-------------ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVV 594

Query: 356 ELLLSCGVSANTMDYGGHTPLHCALQG 382
             L+ CG + N  D  G T L  A  G
Sbjct: 595 NCLIGCGANINHTDQDGWTALRSAAWG 621



 Score = 37.7 bits (86), Expect = 0.023
 Identities = 22/56 (39%), Positives = 32/56 (57%), Gaps = 1/56 (1%)

Query: 163  TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 217
            T L +AA  GH +V+++LL   A P+ A   GRTA+  A   GH+  + +L   GA
Sbjct: 1047 TALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102


>gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Homo
           sapiens]
          Length = 329

 Score =  105 bits (261), Expect = 1e-22
 Identities = 95/305 (31%), Positives = 123/305 (40%), Gaps = 50/305 (16%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
           +PLH AAS+G    LR LL +    ++      T LHEAC   H AC   LL AGA+ N 
Sbjct: 72  SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
              DG  PL      G+  CAELLL +GA+   + E    +P H AA  GH E  D+L+ 
Sbjct: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAK--AQLESCLPSPTHEAASKGHHECLDILIS 189

Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
            G   D       TPL  AC              ++       LL AGAD     +    
Sbjct: 190 WGIDVDQEIPHLGTPLYVAC-------------MSQQFHCIWKLLYAGADVQKG-KYWDT 235

Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
           PLH A ++    +V LLL  G   N  +     P+          +A S   V R LL H
Sbjct: 236 PLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPID---------VATSSSMVERILLQH 286

Query: 402 GAVRVWPGALPKKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRL 461
            A                         P SL  L R  +RS++       +P+L LP  L
Sbjct: 287 EAT------------------------PSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLL 322

Query: 462 LRYLQ 466
             +LQ
Sbjct: 323 KNFLQ 327



 Score = 55.8 bits (133), Expect = 8e-08
 Identities = 48/135 (35%), Positives = 64/135 (47%), Gaps = 11/135 (8%)

Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAG 216
           E  L +P H AAS+GH E L +L+      D   P   T L+ AC +    C+  LL AG
Sbjct: 165 ESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAG 224

Query: 217 ADPNIADQDGK---RPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV 273
           AD     Q GK    PLH      + E   LLL FGA ++ ++ E    P+ VA     V
Sbjct: 225 ADV----QKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLR-PIDVATSSSMV 279

Query: 274 ELADLLLRRGACPDA 288
           E   +LL+  A P +
Sbjct: 280 E--RILLQHEATPSS 292



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 26/91 (28%), Positives = 38/91 (41%), Gaps = 3/91 (3%)

Query: 153 WSLTYEEE---LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACV 209
           W +  ++E   L TPL+VA        +  LL   A         T LH A     T  V
Sbjct: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIV 249

Query: 210 HVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240
           ++LL  GAD N  + +  RP+ +      +E
Sbjct: 250 NLLLEFGADINAKNTELLRPIDVATSSSMVE 280


>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
          Length = 1001

 Score =  104 bits (260), Expect = 2e-22
 Identities = 81/241 (33%), Positives = 113/241 (46%), Gaps = 21/241 (8%)

Query: 149 ALRLWSLTYEEELTTPLHVAASRGHT-EVLRLLLRRRARPDSAPG-GRTALHEACAAGHT 206
           A+  W+  ++++L   +H    RG    V  L  R+ ARP      G++  H A + G T
Sbjct: 13  AVERWN-RHDQKLLEAVH----RGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLT 67

Query: 207 ACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHV 266
            C+ +LL  GAD N  ++DG   LHL       +C ++LL+ GA  D   + E  +PLH 
Sbjct: 68  ECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDA-VDAENRSPLHW 126

Query: 267 AARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLL 326
           AA  G      LL    A  D  + +G TPL+ A             +      +CS LL
Sbjct: 127 AASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIA-------------SLGGHAAICSQLL 173

Query: 327 SAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAA 386
             GA  +  D++ +  L LAC +G A V ELLLS G  A  +D  GH  LH AL     A
Sbjct: 174 QRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKA 233

Query: 387 L 387
           L
Sbjct: 234 L 234



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 59/187 (31%), Positives = 82/187 (43%), Gaps = 21/187 (11%)

Query: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276
           A P   D +G+ P HL    G  EC  +LL  GA ++ ++E+   T LH+A      +  
Sbjct: 45  ARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGS-TALHLATISCQPQCV 103

Query: 277 DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 336
            +LL+ GA  DA +AE  +PL  A    C S                LL    A  D  D
Sbjct: 104 KVLLQHGANEDAVDAENRSPLHWAASSGCASSV-------------LLLCDHEAFLDVLD 150

Query: 337 QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVR 396
            D + PL +A   GHAA+   LL  G   N  D    + L  A +  +A +A+       
Sbjct: 151 NDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAE------- 203

Query: 397 ALLNHGA 403
            LL+HGA
Sbjct: 204 LLLSHGA 210


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  103 bits (258), Expect = 3e-22
 Identities = 82/251 (32%), Positives = 112/251 (44%), Gaps = 22/251 (8%)

Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGG-RTALHEACAAGHTACVHVLLVAG 216
           + E  TPLH AA  G  E++ LL+   AR ++      T LH A A+     V VLL   
Sbjct: 38  DNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHS 97

Query: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276
           AD N  D++ + PLH+      ++CAE L+   + V+  S+    T LH AA  GH E+ 
Sbjct: 98  ADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV-SDRAGRTALHHAAFSGHGEMV 156

Query: 277 DLLLRRGACPDA-----RNAEGWTPLLA-----------ACDVRCQ---SITDAEATTAR 317
            LLL RGA  +A     R A  W   +              +V C+   S T   A  + 
Sbjct: 157 KLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASS 216

Query: 318 -CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPL 376
             + +   LL  G D +  +     PLH+AC  G   VV  L+ CG   N  +  G TPL
Sbjct: 217 GMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276

Query: 377 HCALQGPAAAL 387
           H A      AL
Sbjct: 277 HFAAASTHGAL 287



 Score =  100 bits (250), Expect = 2e-21
 Identities = 78/242 (32%), Positives = 114/242 (47%), Gaps = 29/242 (11%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           TPLH+AA+    +    L+   +  + S   GRTALH A  +GH   V +LL  GA+ N 
Sbjct: 109 TPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINA 168

Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
            D+  +R +H     G +E  +LL+  GA V  + +++  TPLH AA  G + +   LL 
Sbjct: 169 FDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK-DKKSYTPLHAAASSGMISVVKYLLD 227

Query: 282 RGACPDARNAEGWTPLLAAC----DVRCQSITD------------------AEATT--AR 317
            G   +  NA G TPL  AC    DV    + D                  A A+T  A 
Sbjct: 228 LGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL 287

Query: 318 CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377
           CL+   LL+  GAD +   +D + PLH+    G  +  + ++  G   +  D  G+TPLH
Sbjct: 288 CLE---LLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLH 344

Query: 378 CA 379
            A
Sbjct: 345 IA 346



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 81/255 (31%), Positives = 114/255 (44%), Gaps = 44/255 (17%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-----GGRTALHEACAAGHTACVHVLLVAGA 217
           TP+H AA+ GH+E LRLL+   A P +A       G+T L  +   GHT CV+ LL  GA
Sbjct: 619 TPIHAAATNGHSECLRLLIGN-AEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA 677

Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277
           + +  D+ G+  LH     G  EC + LL+ GA+   R +    TP+H++A  GH+ +  
Sbjct: 678 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLR-DSRGRTPIHLSAACGHIGVLG 736

Query: 278 LLLRRGACPDARNA----EGWTPLLAAC--------------------------DVRCQS 307
            LL+  A  DA  A     G+T L  AC                           + C  
Sbjct: 737 ALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAV 796

Query: 308 ITDAEATTARCLQLCSLLLSAGAD-ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSAN 366
           I D E           L+ + GA   +A D   + PLH A    H   ++LLLS     N
Sbjct: 797 INDNEGAAE------MLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850

Query: 367 TMDYGGHTPLHCALQ 381
           ++D  G TPL  A +
Sbjct: 851 SVDSTGKTPLMMAAE 865



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 81/248 (32%), Positives = 112/248 (45%), Gaps = 32/248 (12%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-----GRTALHEACAAGHTACVHVLLVAGA 217
           TP+H++A+ GH  VL  LL+  A  D+ P      G TALH AC  GH  CV +LL    
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV 780

Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLL-RFGARVDGRSEEEEETPLHVAARLGHVELA 276
                + +   PLH          AE+L+   GA +   ++ +  TPLH AA   HVE  
Sbjct: 781 FQK-TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECL 839

Query: 277 DLLLRRGACPDARNAEGWTPLLAACD---VRCQSITDAEATTARCLQ----------LCS 323
            LLL   A  ++ ++ G TPL+ A +        +  + A+    LQ           CS
Sbjct: 840 QLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACS 899

Query: 324 --------LLLSAGADAD---AADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGG 372
                   L+L    D +   A +   Q PLH+A R G   VV+ LL  G S   +D  G
Sbjct: 900 KGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENG 959

Query: 373 HTP-LHCA 379
           +TP L CA
Sbjct: 960 YTPALACA 967



 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 81/249 (32%), Positives = 117/249 (46%), Gaps = 25/249 (10%)

Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIA 222
           PLH+AA  G ++  R LL      D+    GRT LH A A G+  C+++LL  GAD N  
Sbjct: 375 PLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKK 434

Query: 223 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLG-HVELADLLLR 281
           D+ G+ PLH        +C   L+  GA V+   +E   TPLH AA      +  + LLR
Sbjct: 435 DKFGRSPLHYAAANCNYQCLFALVGSGASVND-LDERGCTPLHYAATSDTDGKCLEYLLR 493

Query: 282 RGACPDARNAEGWTPL--LAACDVR-CQSITDAEATTARCLQLCSLLLSAGAD--ADAAD 336
             A P  R+ +G+  +   AA   R C  +  +E        L  L+ ++G D  +D+ +
Sbjct: 494 NDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASET------PLDVLMETSGTDMLSDSDN 547

Query: 337 QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHV-- 394
           +    PLHLA   GH   +E+L+   +  +  +  G TPL          LA    HV  
Sbjct: 548 RATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLD---------LAAFKGHVEC 598

Query: 395 VRALLNHGA 403
           V  L+N GA
Sbjct: 599 VDVLINQGA 607



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 83/262 (31%), Positives = 107/262 (40%), Gaps = 61/262 (23%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHV---------- 211
           +PLH+AA  GH + L +L++     D     GRT L  A   GH  CV V          
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611

Query: 212 -----------------------LLVAGADP----NIADQDGKRPLHLCRGPGTLECAEL 244
                                  LL+  A+P    +I D +G+ PL L    G  +C   
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671

Query: 245 LLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP--LLAACD 302
           LL  GA VD + ++   T LH  A  GH E  D LL+ GA    R++ G TP  L AAC 
Sbjct: 672 LLNKGANVDAK-DKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730

Query: 303 VRCQSITDAEATTARCLQLCSLLLSAGADADA----ADQDKQRPLHLACRRGHAAVVELL 358
                           + +   LL + A  DA    AD      LH AC  GH   VELL
Sbjct: 731 ---------------HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775

Query: 359 LSCGVSANTMDYGGHTPLHCAL 380
           L   V   T +    +PLHCA+
Sbjct: 776 LEQEVFQKT-EGNAFSPLHCAV 796



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 68/219 (31%), Positives = 103/219 (47%), Gaps = 25/219 (11%)

Query: 194 RTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVD 253
           RT LH A   G    + +L+++GA  N  D     PLH      + E  ++LL+  A V+
Sbjct: 42  RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN 101

Query: 254 GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA-- 311
            R ++  +TPLH+AA    V+ A+ L+               PLL+  +V  ++   A  
Sbjct: 102 AR-DKNWQTPLHIAAANKAVKCAEALV---------------PLLSNVNVSDRAGRTALH 145

Query: 312 EATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYG 371
            A  +   ++  LLLS GA+ +A D+  +R +H A   GH  VV+LL+S G      D  
Sbjct: 146 HAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKK 205

Query: 372 GHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGA 410
            +TPLH       AA +     VV+ LL+ G     P A
Sbjct: 206 SYTPLH-------AAASSGMISVVKYLLDLGVDMNEPNA 237



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 61/201 (30%), Positives = 88/201 (43%), Gaps = 20/201 (9%)

Query: 197 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS 256
           LH A   GH   + VL+ +  D ++ +  G+ PL L    G +EC ++L+  GA +  + 
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613

Query: 257 EEEEETPLHVAARLGHVELADLLLRRGA---CPDARNAEGWTPLLAACDVRCQSITDAEA 313
              + TP+H AA  GH E   LL+         D ++  G TPL+ +        TD   
Sbjct: 614 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSV---LNGHTDCVY 670

Query: 314 TTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGH 373
           +          LL+ GA+ DA D+  +  LH     GH   V+ LL  G      D  G 
Sbjct: 671 S----------LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720

Query: 374 TPLH----CALQGPAAALAQS 390
           TP+H    C   G   AL QS
Sbjct: 721 TPIHLSAACGHIGVLGALLQS 741



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 27/73 (36%), Positives = 35/73 (47%), Gaps = 7/73 (9%)

Query: 331 DADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQS 390
           D +  D +K+ PLH A   G A ++ELL+  G   N  D    TPLH        A+A  
Sbjct: 33  DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLH-------RAVASC 85

Query: 391 PEHVVRALLNHGA 403
            E  V+ LL H A
Sbjct: 86  SEEAVQVLLKHSA 98


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score =  103 bits (257), Expect = 3e-22
 Identities = 75/212 (35%), Positives = 108/212 (50%), Gaps = 14/212 (6%)

Query: 191 PGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGA 250
           P G +ALH A   G+T  + +LL A A  +I D  G RPLH     G  E  +L+L+ G+
Sbjct: 47  PDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGS 106

Query: 251 RVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITD 310
            V+  S +E   PLH+AA+ GH +++++LL+  + P   +  G TPL  AC+     +  
Sbjct: 107 AVNIPS-DEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQ 165

Query: 311 AEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 370
              ++     +C+ LL      DA D +   PLHLA + GH  ++ LLL  G+  N    
Sbjct: 166 LLLSS----NMCAALLEP-RPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTK 220

Query: 371 GGHTPLHCALQGPAAALAQSPEHVVRALLNHG 402
            G T LH       AAL    E VVR LL+ G
Sbjct: 221 SG-TALH------EAALCGKTE-VVRLLLDSG 244



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 49/143 (34%), Positives = 67/143 (46%), Gaps = 11/143 (7%)

Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLL-----VAGA 217
           PLH+AA  GH +V  +LL+ ++ P      G+T L  AC  G    V +LL      A  
Sbjct: 118 PLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALL 177

Query: 218 DP---NIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 274
           +P   +  D +G  PLHL    G ++   LLL+ G  +D   + +  T LH AA  G  E
Sbjct: 178 EPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAG--IDINRQTKSGTALHEAALCGKTE 235

Query: 275 LADLLLRRGACPDARNAEGWTPL 297
           +  LLL  G     RN    T L
Sbjct: 236 VVRLLLDSGINAHVRNTYSQTAL 258



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 24/60 (40%), Positives = 36/60 (60%)

Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
           T+PLH+AA  GH +++RLLL+     +      TALHEA   G T  V +LL +G + ++
Sbjct: 190 TSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHV 249



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 35/103 (33%), Positives = 43/103 (41%), Gaps = 10/103 (9%)

Query: 163 TPLHVAASRGHTEVLRLLLRRRA-------RPDSA--PGGRTALHEACAAGHTACVHVLL 213
           TPL +A   G   V++LLL           RP  A  P G + LH A   GH   + +LL
Sbjct: 150 TPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLL 209

Query: 214 VAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS 256
            AG D N   + G   LH     G  E   LLL  G     R+
Sbjct: 210 QAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRN 251


>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
           isoform b [Homo sapiens]
          Length = 1176

 Score =  103 bits (257), Expect = 3e-22
 Identities = 98/354 (27%), Positives = 151/354 (42%), Gaps = 62/354 (17%)

Query: 32  AYTSPPPHSP-FPAHMLMSWSPEECKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGP 90
           A  +PPP S   P     S      +G GEP   R P C  L +                
Sbjct: 527 AAPAPPPLSQDVPGRADTSQPSARMRGHGEP---RRPPCDPLAD---------------- 567

Query: 91  IVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGL-APDSVFDTSDPERWRDFRFNIRA 149
             T  +SGP+L           GC+S +      G  A +      + ER +  RF+ R 
Sbjct: 568 --TIDSSGPSLTLPNG------GCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQ 619

Query: 150 LRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPD---SAPGGRTALHEACAAGHT 206
           L               +++  +G  + + L+L     P+        RT LH A   G  
Sbjct: 620 L---------------YLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSV 664

Query: 207 ACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHV 266
              HVLL AGA+ N  D+  + PL        LE A  +++ G  V  + EE+  T LH 
Sbjct: 665 EICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK-EEDGSTCLHH 723

Query: 267 AARLGHVELADLLLRRGACP-DARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLL 325
           AA++G++E+  LLL  G    +A+++ GWTP++ A +              + +++  +L
Sbjct: 724 AAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAE-------------HKHIEVIRML 770

Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           L+ GAD    D ++   LH A   G AA+ E+LL+     + ++Y G TPLH A
Sbjct: 771 LTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 824



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 52/141 (36%), Positives = 71/141 (50%), Gaps = 5/141 (3%)

Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP--GGRTALHEACAAGHTACVHVLLVA 215
           EE+ +T LH AA  G+ E++ LLL       +A   GG T +  A    H   + +LL  
Sbjct: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773

Query: 216 GADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEE-ETPLHVAARLGHVE 274
           GAD  + D +    LH     G+   AE+LL   AR D  +     +TPLH+AAR  + +
Sbjct: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLN--ARCDLHAVNYHGDTPLHIAARESYHD 831

Query: 275 LADLLLRRGACPDARNAEGWT 295
              L L RGA P+ RN EG T
Sbjct: 832 CVLLFLSRGANPELRNKEGDT 852


>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
           isoform a [Homo sapiens]
          Length = 1210

 Score =  103 bits (257), Expect = 3e-22
 Identities = 98/354 (27%), Positives = 151/354 (42%), Gaps = 62/354 (17%)

Query: 32  AYTSPPPHSP-FPAHMLMSWSPEECKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGP 90
           A  +PPP S   P     S      +G GEP   R P C  L +                
Sbjct: 561 AAPAPPPLSQDVPGRADTSQPSARMRGHGEP---RRPPCDPLAD---------------- 601

Query: 91  IVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGL-APDSVFDTSDPERWRDFRFNIRA 149
             T  +SGP+L           GC+S +      G  A +      + ER +  RF+ R 
Sbjct: 602 --TIDSSGPSLTLPNG------GCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQ 653

Query: 150 LRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPD---SAPGGRTALHEACAAGHT 206
           L               +++  +G  + + L+L     P+        RT LH A   G  
Sbjct: 654 L---------------YLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSV 698

Query: 207 ACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHV 266
              HVLL AGA+ N  D+  + PL        LE A  +++ G  V  + EE+  T LH 
Sbjct: 699 EICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK-EEDGSTCLHH 757

Query: 267 AARLGHVELADLLLRRGACP-DARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLL 325
           AA++G++E+  LLL  G    +A+++ GWTP++ A +              + +++  +L
Sbjct: 758 AAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAE-------------HKHIEVIRML 804

Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
           L+ GAD    D ++   LH A   G AA+ E+LL+     + ++Y G TPLH A
Sbjct: 805 LTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 858



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 52/141 (36%), Positives = 71/141 (50%), Gaps = 5/141 (3%)

Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP--GGRTALHEACAAGHTACVHVLLVA 215
           EE+ +T LH AA  G+ E++ LLL       +A   GG T +  A    H   + +LL  
Sbjct: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807

Query: 216 GADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEE-ETPLHVAARLGHVE 274
           GAD  + D +    LH     G+   AE+LL   AR D  +     +TPLH+AAR  + +
Sbjct: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLN--ARCDLHAVNYHGDTPLHIAARESYHD 865

Query: 275 LADLLLRRGACPDARNAEGWT 295
              L L RGA P+ RN EG T
Sbjct: 866 CVLLFLSRGANPELRNKEGDT 886


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.430 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,872,311
Number of Sequences: 37866
Number of extensions: 1117158
Number of successful extensions: 8655
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 352
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 3088
Number of HSP's gapped (non-prelim): 2048
length of query: 474
length of database: 18,247,518
effective HSP length: 106
effective length of query: 368
effective length of database: 14,233,722
effective search space: 5238009696
effective search space used: 5238009696
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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