BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2 [Homo sapiens] (474 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 972 0.0 gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 953 0.0 gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3... 642 0.0 gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo sap... 279 3e-75 gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [H... 221 1e-57 gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isof... 174 2e-43 gi|22208964 ankyrin repeat and SOCS box-containing protein 4 iso... 141 1e-33 gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 126 4e-29 gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 126 4e-29 gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 126 4e-29 gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 122 5e-28 gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 122 5e-28 gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 122 5e-28 gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 122 5e-28 gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 122 5e-28 gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 120 3e-27 gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 115 7e-26 gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 110 4e-24 gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 110 4e-24 gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 110 4e-24 gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 109 5e-24 gi|89363047 death-associated protein kinase 1 [Homo sapiens] 108 8e-24 gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 107 3e-23 gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 105 9e-23 gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Ho... 105 1e-22 gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 104 2e-22 gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 103 3e-22 gi|18079216 CASK interacting protein 1 [Homo sapiens] 103 3e-22 gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 103 3e-22 gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 103 3e-22 >gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2 [Homo sapiens] Length = 474 Score = 972 bits (2512), Expect = 0.0 Identities = 474/474 (100%), Positives = 474/474 (100%) Query: 1 MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE 60 MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE Sbjct: 1 MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE 60 Query: 61 PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA 120 PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA Sbjct: 61 PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA 120 Query: 121 DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL 180 DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL Sbjct: 121 DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL 180 Query: 181 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE Sbjct: 181 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240 Query: 241 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 300 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA Sbjct: 241 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 300 Query: 301 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS 360 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS Sbjct: 301 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS 360 Query: 361 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKKHQRFYS 420 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKKHQRFYS Sbjct: 361 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKKHQRFYS 420 Query: 421 SLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 474 SLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY Sbjct: 421 SLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 474 >gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1 [Homo sapiens] Length = 512 Score = 953 bits (2463), Expect = 0.0 Identities = 474/512 (92%), Positives = 474/512 (92%), Gaps = 38/512 (7%) Query: 1 MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE 60 MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE Sbjct: 1 MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE 60 Query: 61 PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA 120 PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA Sbjct: 61 PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA 120 Query: 121 DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL 180 DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL Sbjct: 121 DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL 180 Query: 181 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE Sbjct: 181 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240 Query: 241 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 300 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA Sbjct: 241 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 300 Query: 301 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS 360 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS Sbjct: 301 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS 360 Query: 361 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPK------- 413 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPK Sbjct: 361 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWST 420 Query: 414 -------------------------------KHQRFYSSLFALVRQPRSLQHLSRCALRS 442 KHQRFYSSLFALVRQPRSLQHLSRCALRS Sbjct: 421 CPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRS 480 Query: 443 HLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 474 HLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY Sbjct: 481 HLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 512 >gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3 [Homo sapiens] Length = 452 Score = 642 bits (1655), Expect = 0.0 Identities = 332/412 (80%), Positives = 340/412 (82%), Gaps = 45/412 (10%) Query: 101 LAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEE 160 +A A+ GD+ + + P S D R + R++ LWSLTYEEE Sbjct: 48 MALQNALYTGDLARLQELFP-------PHSTADLLLESRAAEPRWSSHQRGLWSLTYEEE 100 Query: 161 LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPN 220 LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPN Sbjct: 101 LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPN 160 Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 280 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL Sbjct: 161 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 220 Query: 281 RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 340 RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ Sbjct: 221 RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 280 Query: 341 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN 400 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN Sbjct: 281 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN 340 Query: 401 HGAVRVWPGALPK--------------------------------------KHQRFYSSL 422 HGAVRVWPGALPK KHQRFYSSL Sbjct: 341 HGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSL 400 Query: 423 FALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 474 FALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY Sbjct: 401 FALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 452 >gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo sapiens] Length = 466 Score = 279 bits (714), Expect = 3e-75 Identities = 164/361 (45%), Positives = 198/361 (54%), Gaps = 43/361 (11%) Query: 152 LWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHV 211 LW+L Y+ ELTTPL +AA+ GHT +R LL R A PD++PGGR ALHEAC GHTACV + Sbjct: 111 LWTLEYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRL 170 Query: 212 LLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLG 271 LL ADP++ +G PLHLCR +L CA+ LL GA V +TPLHVAA+ G Sbjct: 171 LLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRG 230 Query: 272 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331 E A L L RGA DARN G T L AAC RCL+LC+LLL GA+ Sbjct: 231 LDEHARLYLGRGAHVDARNGRGETALSAAC-----GAARRPDEHGRCLRLCALLLRRGAE 285 Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391 ADA D+D++ PLH AC ++ LLL G A +DYGG +PL LQ + AL SP Sbjct: 286 ADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASP 345 Query: 392 EHVVRALLNHGAVRVWPGALPK-------------------------------------- 413 + V+ALLNHG+ VWP A PK Sbjct: 346 QRTVQALLNHGSPTVWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQ 405 Query: 414 KHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVL 473 H+ FY SLFAL PR LQHL RCALR +P LPLP L YL L+ +GVL Sbjct: 406 MHKPFYQSLFALALTPRCLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVL 465 Query: 474 Y 474 + Sbjct: 466 H 466 >gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [Homo sapiens] Length = 453 Score = 221 bits (562), Expect = 1e-57 Identities = 139/355 (39%), Positives = 180/355 (50%), Gaps = 39/355 (10%) Query: 153 WSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVL 212 W LT + + T PL +A +RG+T+ R L+R+ A D+ GGR ALHEACA CV +L Sbjct: 103 WVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLL 162 Query: 213 LVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGH 272 L GA N+ ++G PLHLC P +L+CA+LLL GA V+ + E +ETPLHVAA G Sbjct: 163 LTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGL 222 Query: 273 VELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADA 332 + L L GA R ++G T L AC + + + R LL AGADA Sbjct: 223 EQHVALYLEHGADVGLRTSQGETALNTAC-----AGAEGPGSCRRHQAAARRLLEAGADA 277 Query: 333 DAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPE 392 AA + + PLH AC G + ELLL G A + GHTP+ CALQ + PE Sbjct: 278 RAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPE 337 Query: 393 HVVRALLNHGAVRVWPGALP----------------------------------KKHQRF 418 + ALL++GA V P L K+H+ F Sbjct: 338 VLFAALLDYGAQPVRPEMLKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAF 397 Query: 419 YSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVL 473 YSS +V QPR LQHL+R A+R+ L Q RLPLPP L YL L EG + Sbjct: 398 YSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLLLRVEGCI 452 Score = 57.8 bits (138), Expect = 2e-08 Identities = 46/126 (36%), Positives = 57/126 (45%), Gaps = 9/126 (7%) Query: 137 PERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRT 195 PE + + + A +L E TPLHVAA+RG + + L L A G T Sbjct: 186 PESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGET 245 Query: 196 ALHEACAAG--------HTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR 247 AL+ ACA H A LL AGAD A + PLH G AELLLR Sbjct: 246 ALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLR 305 Query: 248 FGARVD 253 +GAR + Sbjct: 306 YGARAE 311 >gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isoform a [Homo sapiens] Length = 426 Score = 174 bits (440), Expect = 2e-43 Identities = 135/430 (31%), Positives = 191/430 (44%), Gaps = 53/430 (12%) Query: 85 KSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFR 144 KSG +V R F +A+ + D G + IL + D+VF+ D Sbjct: 10 KSGAAKLVKRN-------FLEALKSNDFGKLKAILIQRQIDV--DTVFEVEDENMV--LA 58 Query: 145 FNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAG 204 + L S + T LH++ GH E L +LL A + P G+T LH AC Sbjct: 59 SYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMA 118 Query: 205 HTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR-SEEEEETP 263 + CV +L GA N G LH C P ++ CA+ L+ GA V+ + + ++EETP Sbjct: 119 NVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETP 178 Query: 264 LHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCS 323 LH AA G EL + GA D+ NA TPL A + E +T L +C Sbjct: 179 LHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAA-YWALRFKEQEYSTEHHL-VCR 236 Query: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 383 +LL A+ +A D D + PLH A ++ ++L G AN MD G + L+ Sbjct: 237 MLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVT 296 Query: 384 AAALAQSPEHVVRALLNHGAVRV----------------------------------WPG 409 + A PE + LLNHGA R+ W Sbjct: 297 SVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRR 356 Query: 410 ALP----KKHQRFYSSLFAL-VRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRY 464 A+P +K+ FY SLF + PR+L HLSRCA+R L +A+P L LP L +Y Sbjct: 357 AIPDDDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKY 416 Query: 465 LQLDFEGVLY 474 L L+ EG++Y Sbjct: 417 LLLEPEGIIY 426 >gi|22208964 ankyrin repeat and SOCS box-containing protein 4 isoform b [Homo sapiens] Length = 349 Score = 141 bits (356), Expect = 1e-33 Identities = 104/325 (32%), Positives = 149/325 (45%), Gaps = 14/325 (4%) Query: 85 KSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFR 144 KSG +V R F +A+ + D G + IL + D+VF+ D Sbjct: 10 KSGAAKLVKRN-------FLEALKSNDFGKLKAILIQRQIDV--DTVFEVEDENMV--LA 58 Query: 145 FNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAG 204 + L S + T LH++ GH E L +LL A + P G+T LH AC Sbjct: 59 SYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMA 118 Query: 205 HTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR-SEEEEETP 263 + CV +L GA N G LH C P ++ CA+ L+ GA V+ + + ++EETP Sbjct: 119 NVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETP 178 Query: 264 LHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCS 323 LH AA G EL + GA D+ NA TPL A + E +T L +C Sbjct: 179 LHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAA-YWALRFKEQEYSTEHHL-VCR 236 Query: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 383 +LL A+ +A D D + PLH A ++ ++L G AN MD G + L+ Sbjct: 237 MLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVT 296 Query: 384 AAALAQSPEHVVRALLNHGAVRVWP 408 + A PE + LLNHGA R++P Sbjct: 297 SVRPAAQPEICYQLLLNHGAARIYP 321 >gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] Length = 1863 Score = 126 bits (317), Expect = 4e-29 Identities = 89/245 (36%), Positives = 123/245 (50%), Gaps = 22/245 (8%) Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGAD 218 E TPLH+A+ G TE+++LLL+ A PD+A G T LH + G VLL AGA Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534 Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278 ++A + G PLH+ G+L+ A+LLL+ A D + TPLHVAA + ++A L Sbjct: 535 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQKVALL 593 Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQD 338 LL +GA P A G+TPL A +Q+ S LL+ GA+ + + Sbjct: 594 LLEKGASPHATAKNGYTPLHIAAK-------------KNQMQIASTLLNYGAETNIVTKQ 640 Query: 339 KQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRAL 398 PLHLA + GH +V LLL G + + G T LH A Q + +V L Sbjct: 641 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ-------EDKVNVADIL 693 Query: 399 LNHGA 403 HGA Sbjct: 694 TKHGA 698 Score = 123 bits (309), Expect = 3e-28 Identities = 89/262 (33%), Positives = 127/262 (48%), Gaps = 29/262 (11%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+A + +V+ LL++ A + G T +H A GH V +LL GA P++ Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 + G+ LH+ G +E LLR GA VD R+ EE+TPLH+A+RLG E+ LLL+ Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQ 497 Query: 282 RGACPDARNAEGWTPLLAAC-----DV--------RCQSITDAEATTA-------RCLQL 321 A PDA G+TPL + DV S+ + T L + Sbjct: 498 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 557 Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381 LLL A AD+A ++ PLH+A + V LLL G S + G+TPLH A + Sbjct: 558 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 617 Query: 382 GPAAALAQSPEHVVRALLNHGA 403 ++ + LLN+GA Sbjct: 618 -------KNQMQIASTLLNYGA 632 Score = 121 bits (304), Expect = 1e-27 Identities = 84/242 (34%), Positives = 117/242 (48%), Gaps = 22/242 (9%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLHVAA G +V +LLL+RRA DSA G T LH A + +LL GA P+ Sbjct: 544 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 603 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 ++G PLH+ ++ A LL +GA + +++ TPLH+A++ GH ++ LLL Sbjct: 604 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTLLLD 662 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 +GA G T L A ++ D +L GAD DA + Sbjct: 663 KGANIHMSTKSGLTSLHLAAQEDKVNVAD-------------ILTKHGADQDAHTKLGYT 709 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401 PL +AC G+ +V LL G + N G+TPLH A Q Q H++ LL H Sbjct: 710 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQH 762 Query: 402 GA 403 GA Sbjct: 763 GA 764 Score = 115 bits (289), Expect = 7e-26 Identities = 77/216 (35%), Positives = 108/216 (50%), Gaps = 15/216 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221 +PLH+AA H E ++ LL+ +A D TALH A GH +LL A+PN Sbjct: 313 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 372 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +G PLH+ ++ ELL+++GA + + E TP+HVAA +GH+ + LLL+ Sbjct: 373 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVAAFMGHLNIVLLLLQ 431 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 GA PD N G T L A + RC LL GA DA +++Q Sbjct: 432 NGASPDVTNIRGETALHMAARA-------GQVEVVRC------LLRNGALVDARAREEQT 478 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377 PLH+A R G +V+LLL + G+TPLH Sbjct: 479 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 514 Score = 109 bits (272), Expect = 6e-24 Identities = 75/218 (34%), Positives = 105/218 (48%), Gaps = 15/218 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLHVAA + +V LLL + A P + A G T LH A LL GA+ NI Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 + G PLHL G + LLL GA + S + T LH+AA+ V +AD+L + Sbjct: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIH-MSTKSGLTSLHLAAQEDKVNVADILTK 695 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 GA DA G+TPL+ AC +++ + LL GA+ +A ++ Sbjct: 696 HGADQDAHTKLGYTPLIVACHYGN-------------VKMVNFLLKQGANVNAKTKNGYT 742 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 PLH A ++GH ++ +LL G N G+T L A Sbjct: 743 PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 780 Score = 100 bits (248), Expect = 4e-21 Identities = 88/254 (34%), Positives = 108/254 (42%), Gaps = 42/254 (16%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPL++AA H +V++ LL A +A G T L A GH V +LL Sbjct: 111 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN------ 164 Query: 222 ADQDGK---RPLHLCRGPGTLECAELLLRFGARVD-------GRSEEEEETPLHVAARLG 271 D GK LH+ + A LLL+ D R+ E TPLH+AA G Sbjct: 165 -DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 223 Query: 272 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331 +V +A LLL RGA D G TPL + T + LLL G Sbjct: 224 NVNVATLLLNRGAAVDFTARNGITPL---------HVASKRGNT----NMVKLLLDRGGQ 270 Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391 DA +D PLH A R GH VVELLL G G +PLH A QG Sbjct: 271 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--------- 321 Query: 392 EHV--VRALLNHGA 403 +HV V+ LL H A Sbjct: 322 DHVECVKHLLQHKA 335 Score = 98.6 bits (244), Expect = 1e-20 Identities = 76/218 (34%), Positives = 103/218 (47%), Gaps = 15/218 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+AA G+ V LLL R A D +A G T LH A G+T V +LL G + Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +DG PLH G + ELLL GA + R++ +PLH+AA+ HVE LL+ Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQ 332 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 A D + T L A +T LLL A+ +A + Sbjct: 333 HKAPVDDVTLDYLTALHVAAHCGHYRVT-------------KLLLDKRANPNARALNGFT 379 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 PLH+AC++ V+ELL+ G S + G TP+H A Sbjct: 380 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 417 Score = 90.1 bits (222), Expect = 4e-18 Identities = 78/264 (29%), Positives = 117/264 (44%), Gaps = 33/264 (12%) Query: 165 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 223 LH+AA GH +++ LL R + DSA G TALH A AG V VL+ GA+ N Sbjct: 47 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 106 Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR- 282 Q+G PL++ ++ + LL GA + E+ TPL VA + GH + +LL Sbjct: 107 QNGFTPLYMAAQENHIDVVKYLLENGAN-QSTATEDGFTPLAVALQQGHNQAVAILLEND 165 Query: 283 -------------GACPDARNAEGWTPLLAACDVRCQSITDAEATTARC----------L 319 D ++A DV+ + + + + + Sbjct: 166 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 225 Query: 320 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 + +LLL+ GA D ++ PLH+A +RG+ +V+LLL G + G TPLHCA Sbjct: 226 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 285 Query: 380 LQGPAAALAQSPEHVVRALLNHGA 403 + + VV LL GA Sbjct: 286 AR-------SGHDQVVELLLERGA 302 Score = 78.2 bits (191), Expect = 2e-14 Identities = 52/149 (34%), Positives = 78/149 (52%), Gaps = 2/149 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+A+ GHT+++ LLL + A S G T+LH A +L GAD + Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 + G PL + G ++ LL+ GA V+ +++ TPLH AA+ GH + ++LL+ Sbjct: 703 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQAAQQGHTHIINVLLQ 761 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310 GA P+A A G T L A + S+ D Sbjct: 762 HGAKPNATTANGNTALAIAKRLGYISVVD 790 Score = 75.9 bits (185), Expect = 8e-14 Identities = 66/234 (28%), Positives = 100/234 (42%), Gaps = 32/234 (13%) Query: 193 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARV 252 G ALH A GH V LL G+ + A + G LH+ G E ++L++ GA + Sbjct: 43 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 102 Query: 253 DGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC----------- 301 + +S + TPL++AA+ H+++ LL GA +G+TPL A Sbjct: 103 NAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161 Query: 302 ---DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ----------RPLHLACR 348 D + + A AR S L D +A Q K PLH+A Sbjct: 162 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 221 Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHG 402 G+ V LLL+ G + + G TPLH A + + ++V+ LL+ G Sbjct: 222 YGNVNVATLLLNRGAAVDFTARNGITPLHVASK-------RGNTNMVKLLLDRG 268 Score = 65.9 bits (159), Expect = 8e-11 Identities = 48/160 (30%), Positives = 75/160 (46%), Gaps = 14/160 (8%) Query: 200 ACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEE 259 A AG+ V L G D N +Q+G LHL G + + LL G+ VD + ++ Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDS-ATKK 75 Query: 260 EETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCL 319 T LH+A+ G E+ +L++ GA +A++ G+TPL A + Sbjct: 76 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ-------------ENHI 122 Query: 320 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 359 + LL GA+ A +D PL +A ++GH V +LL Sbjct: 123 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162 Score = 48.9 bits (115), Expect = 1e-05 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 1/84 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPL VA G+ +++ LL++ A ++ G T LH+A GHT ++VLL GA PN Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768 Query: 222 ADQDGKRPLHLCRGPGTLECAELL 245 +G L + + G + + L Sbjct: 769 TTANGNTALAIAKRLGYISVVDTL 792 Score = 42.7 bits (99), Expect = 7e-04 Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 7/78 (8%) Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385 L G D + +Q+ LHLA + GH +V+ LL G S ++ G+T LH A Sbjct: 30 LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH------IA 83 Query: 386 ALAQSPEHVVRALLNHGA 403 +LA E VV+ L+ GA Sbjct: 84 SLAGQAE-VVKVLVKEGA 100 >gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] Length = 1872 Score = 126 bits (317), Expect = 4e-29 Identities = 89/245 (36%), Positives = 123/245 (50%), Gaps = 22/245 (8%) Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGAD 218 E TPLH+A+ G TE+++LLL+ A PD+A G T LH + G VLL AGA Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555 Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278 ++A + G PLH+ G+L+ A+LLL+ A D + TPLHVAA + ++A L Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQKVALL 614 Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQD 338 LL +GA P A G+TPL A +Q+ S LL+ GA+ + + Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAK-------------KNQMQIASTLLNYGAETNIVTKQ 661 Query: 339 KQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRAL 398 PLHLA + GH +V LLL G + + G T LH A Q + +V L Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ-------EDKVNVADIL 714 Query: 399 LNHGA 403 HGA Sbjct: 715 TKHGA 719 Score = 123 bits (309), Expect = 3e-28 Identities = 89/262 (33%), Positives = 127/262 (48%), Gaps = 29/262 (11%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+A + +V+ LL++ A + G T +H A GH V +LL GA P++ Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 + G+ LH+ G +E LLR GA VD R+ EE+TPLH+A+RLG E+ LLL+ Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQ 518 Query: 282 RGACPDARNAEGWTPLLAAC-----DV--------RCQSITDAEATTA-------RCLQL 321 A PDA G+TPL + DV S+ + T L + Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578 Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381 LLL A AD+A ++ PLH+A + V LLL G S + G+TPLH A + Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638 Query: 382 GPAAALAQSPEHVVRALLNHGA 403 ++ + LLN+GA Sbjct: 639 -------KNQMQIASTLLNYGA 653 Score = 121 bits (304), Expect = 1e-27 Identities = 84/242 (34%), Positives = 117/242 (48%), Gaps = 22/242 (9%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLHVAA G +V +LLL+RRA DSA G T LH A + +LL GA P+ Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 ++G PLH+ ++ A LL +GA + +++ TPLH+A++ GH ++ LLL Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTLLLD 683 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 +GA G T L A ++ D +L GAD DA + Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVAD-------------ILTKHGADQDAHTKLGYT 730 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401 PL +AC G+ +V LL G + N G+TPLH A Q Q H++ LL H Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQH 783 Query: 402 GA 403 GA Sbjct: 784 GA 785 Score = 115 bits (289), Expect = 7e-26 Identities = 77/216 (35%), Positives = 108/216 (50%), Gaps = 15/216 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221 +PLH+AA H E ++ LL+ +A D TALH A GH +LL A+PN Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +G PLH+ ++ ELL+++GA + + E TP+HVAA +GH+ + LLL+ Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVAAFMGHLNIVLLLLQ 452 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 GA PD N G T L A + RC LL GA DA +++Q Sbjct: 453 NGASPDVTNIRGETALHMAARA-------GQVEVVRC------LLRNGALVDARAREEQT 499 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377 PLH+A R G +V+LLL + G+TPLH Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535 Score = 109 bits (272), Expect = 6e-24 Identities = 75/218 (34%), Positives = 105/218 (48%), Gaps = 15/218 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLHVAA + +V LLL + A P + A G T LH A LL GA+ NI Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 + G PLHL G + LLL GA + S + T LH+AA+ V +AD+L + Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIH-MSTKSGLTSLHLAAQEDKVNVADILTK 716 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 GA DA G+TPL+ AC +++ + LL GA+ +A ++ Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGN-------------VKMVNFLLKQGANVNAKTKNGYT 763 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 PLH A ++GH ++ +LL G N G+T L A Sbjct: 764 PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801 Score = 100 bits (248), Expect = 4e-21 Identities = 88/254 (34%), Positives = 108/254 (42%), Gaps = 42/254 (16%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPL++AA H +V++ LL A +A G T L A GH V +LL Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN------ 185 Query: 222 ADQDGK---RPLHLCRGPGTLECAELLLRFGARVD-------GRSEEEEETPLHVAARLG 271 D GK LH+ + A LLL+ D R+ E TPLH+AA G Sbjct: 186 -DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 244 Query: 272 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331 +V +A LLL RGA D G TPL + T + LLL G Sbjct: 245 NVNVATLLLNRGAAVDFTARNGITPL---------HVASKRGNT----NMVKLLLDRGGQ 291 Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391 DA +D PLH A R GH VVELLL G G +PLH A QG Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--------- 342 Query: 392 EHV--VRALLNHGA 403 +HV V+ LL H A Sbjct: 343 DHVECVKHLLQHKA 356 Score = 98.6 bits (244), Expect = 1e-20 Identities = 76/218 (34%), Positives = 103/218 (47%), Gaps = 15/218 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+AA G+ V LLL R A D +A G T LH A G+T V +LL G + Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +DG PLH G + ELLL GA + R++ +PLH+AA+ HVE LL+ Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQ 353 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 A D + T L A +T LLL A+ +A + Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVT-------------KLLLDKRANPNARALNGFT 400 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 PLH+AC++ V+ELL+ G S + G TP+H A Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438 Score = 90.1 bits (222), Expect = 4e-18 Identities = 78/264 (29%), Positives = 117/264 (44%), Gaps = 33/264 (12%) Query: 165 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 223 LH+AA GH +++ LL R + DSA G TALH A AG V VL+ GA+ N Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127 Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR- 282 Q+G PL++ ++ + LL GA + E+ TPL VA + GH + +LL Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGAN-QSTATEDGFTPLAVALQQGHNQAVAILLEND 186 Query: 283 -------------GACPDARNAEGWTPLLAACDVRCQSITDAEATTARC----------L 319 D ++A DV+ + + + + + Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 246 Query: 320 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 + +LLL+ GA D ++ PLH+A +RG+ +V+LLL G + G TPLHCA Sbjct: 247 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 306 Query: 380 LQGPAAALAQSPEHVVRALLNHGA 403 + + VV LL GA Sbjct: 307 AR-------SGHDQVVELLLERGA 323 Score = 78.2 bits (191), Expect = 2e-14 Identities = 52/149 (34%), Positives = 78/149 (52%), Gaps = 2/149 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+A+ GHT+++ LLL + A S G T+LH A +L GAD + Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 + G PL + G ++ LL+ GA V+ +++ TPLH AA+ GH + ++LL+ Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQAAQQGHTHIINVLLQ 782 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310 GA P+A A G T L A + S+ D Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVD 811 Score = 75.9 bits (185), Expect = 8e-14 Identities = 66/234 (28%), Positives = 100/234 (42%), Gaps = 32/234 (13%) Query: 193 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARV 252 G ALH A GH V LL G+ + A + G LH+ G E ++L++ GA + Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123 Query: 253 DGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC----------- 301 + +S + TPL++AA+ H+++ LL GA +G+TPL A Sbjct: 124 NAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182 Query: 302 ---DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ----------RPLHLACR 348 D + + A AR S L D +A Q K PLH+A Sbjct: 183 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242 Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHG 402 G+ V LLL+ G + + G TPLH A + + ++V+ LL+ G Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASK-------RGNTNMVKLLLDRG 289 Score = 70.1 bits (170), Expect = 4e-12 Identities = 53/178 (29%), Positives = 83/178 (46%), Gaps = 15/178 (8%) Query: 182 RRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLEC 241 +RR RP + + L A AG+ V L G D N +Q+G LHL G + Sbjct: 21 QRRKRPKKSDSNASFLR-AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGL 79 Query: 242 AELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC 301 + LL G+ VD + ++ T LH+A+ G E+ +L++ GA +A++ G+TPL A Sbjct: 80 VQELLGRGSSVDS-ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 138 Query: 302 DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 359 + + LL GA+ A +D PL +A ++GH V +LL Sbjct: 139 Q-------------ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183 Score = 48.9 bits (115), Expect = 1e-05 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 1/84 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPL VA G+ +++ LL++ A ++ G T LH+A GHT ++VLL GA PN Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789 Query: 222 ADQDGKRPLHLCRGPGTLECAELL 245 +G L + + G + + L Sbjct: 790 TTANGNTALAIAKRLGYISVVDTL 813 Score = 42.7 bits (99), Expect = 7e-04 Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 7/78 (8%) Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385 L G D + +Q+ LHLA + GH +V+ LL G S ++ G+T LH A Sbjct: 51 LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH------IA 104 Query: 386 ALAQSPEHVVRALLNHGA 403 +LA E VV+ L+ GA Sbjct: 105 SLAGQAE-VVKVLVKEGA 121 >gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] Length = 3957 Score = 126 bits (317), Expect = 4e-29 Identities = 89/245 (36%), Positives = 123/245 (50%), Gaps = 22/245 (8%) Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGAD 218 E TPLH+A+ G TE+++LLL+ A PD+A G T LH + G VLL AGA Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555 Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278 ++A + G PLH+ G+L+ A+LLL+ A D + TPLHVAA + ++A L Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQKVALL 614 Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQD 338 LL +GA P A G+TPL A +Q+ S LL+ GA+ + + Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAK-------------KNQMQIASTLLNYGAETNIVTKQ 661 Query: 339 KQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRAL 398 PLHLA + GH +V LLL G + + G T LH A Q + +V L Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ-------EDKVNVADIL 714 Query: 399 LNHGA 403 HGA Sbjct: 715 TKHGA 719 Score = 123 bits (309), Expect = 3e-28 Identities = 89/262 (33%), Positives = 127/262 (48%), Gaps = 29/262 (11%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+A + +V+ LL++ A + G T +H A GH V +LL GA P++ Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 + G+ LH+ G +E LLR GA VD R+ EE+TPLH+A+RLG E+ LLL+ Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQ 518 Query: 282 RGACPDARNAEGWTPLLAAC-----DV--------RCQSITDAEATTA-------RCLQL 321 A PDA G+TPL + DV S+ + T L + Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578 Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381 LLL A AD+A ++ PLH+A + V LLL G S + G+TPLH A + Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638 Query: 382 GPAAALAQSPEHVVRALLNHGA 403 ++ + LLN+GA Sbjct: 639 -------KNQMQIASTLLNYGA 653 Score = 121 bits (304), Expect = 1e-27 Identities = 84/242 (34%), Positives = 117/242 (48%), Gaps = 22/242 (9%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLHVAA G +V +LLL+RRA DSA G T LH A + +LL GA P+ Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 ++G PLH+ ++ A LL +GA + +++ TPLH+A++ GH ++ LLL Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTLLLD 683 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 +GA G T L A ++ D +L GAD DA + Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVAD-------------ILTKHGADQDAHTKLGYT 730 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401 PL +AC G+ +V LL G + N G+TPLH A Q Q H++ LL H Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQH 783 Query: 402 GA 403 GA Sbjct: 784 GA 785 Score = 115 bits (289), Expect = 7e-26 Identities = 77/216 (35%), Positives = 108/216 (50%), Gaps = 15/216 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221 +PLH+AA H E ++ LL+ +A D TALH A GH +LL A+PN Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +G PLH+ ++ ELL+++GA + + E TP+HVAA +GH+ + LLL+ Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVAAFMGHLNIVLLLLQ 452 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 GA PD N G T L A + RC LL GA DA +++Q Sbjct: 453 NGASPDVTNIRGETALHMAARA-------GQVEVVRC------LLRNGALVDARAREEQT 499 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377 PLH+A R G +V+LLL + G+TPLH Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535 Score = 109 bits (272), Expect = 6e-24 Identities = 75/218 (34%), Positives = 105/218 (48%), Gaps = 15/218 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLHVAA + +V LLL + A P + A G T LH A LL GA+ NI Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 + G PLHL G + LLL GA + S + T LH+AA+ V +AD+L + Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIH-MSTKSGLTSLHLAAQEDKVNVADILTK 716 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 GA DA G+TPL+ AC +++ + LL GA+ +A ++ Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGN-------------VKMVNFLLKQGANVNAKTKNGYT 763 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 PLH A ++GH ++ +LL G N G+T L A Sbjct: 764 PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801 Score = 100 bits (248), Expect = 4e-21 Identities = 88/254 (34%), Positives = 108/254 (42%), Gaps = 42/254 (16%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPL++AA H +V++ LL A +A G T L A GH V +LL Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN------ 185 Query: 222 ADQDGK---RPLHLCRGPGTLECAELLLRFGARVD-------GRSEEEEETPLHVAARLG 271 D GK LH+ + A LLL+ D R+ E TPLH+AA G Sbjct: 186 -DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 244 Query: 272 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331 +V +A LLL RGA D G TPL + T + LLL G Sbjct: 245 NVNVATLLLNRGAAVDFTARNGITPL---------HVASKRGNT----NMVKLLLDRGGQ 291 Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391 DA +D PLH A R GH VVELLL G G +PLH A QG Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--------- 342 Query: 392 EHV--VRALLNHGA 403 +HV V+ LL H A Sbjct: 343 DHVECVKHLLQHKA 356 Score = 98.6 bits (244), Expect = 1e-20 Identities = 76/218 (34%), Positives = 103/218 (47%), Gaps = 15/218 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+AA G+ V LLL R A D +A G T LH A G+T V +LL G + Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +DG PLH G + ELLL GA + R++ +PLH+AA+ HVE LL+ Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQ 353 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 A D + T L A +T LLL A+ +A + Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVT-------------KLLLDKRANPNARALNGFT 400 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 PLH+AC++ V+ELL+ G S + G TP+H A Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438 Score = 90.1 bits (222), Expect = 4e-18 Identities = 78/264 (29%), Positives = 117/264 (44%), Gaps = 33/264 (12%) Query: 165 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 223 LH+AA GH +++ LL R + DSA G TALH A AG V VL+ GA+ N Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127 Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR- 282 Q+G PL++ ++ + LL GA + E+ TPL VA + GH + +LL Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGAN-QSTATEDGFTPLAVALQQGHNQAVAILLEND 186 Query: 283 -------------GACPDARNAEGWTPLLAACDVRCQSITDAEATTARC----------L 319 D ++A DV+ + + + + + Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 246 Query: 320 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 + +LLL+ GA D ++ PLH+A +RG+ +V+LLL G + G TPLHCA Sbjct: 247 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 306 Query: 380 LQGPAAALAQSPEHVVRALLNHGA 403 + + VV LL GA Sbjct: 307 AR-------SGHDQVVELLLERGA 323 Score = 78.2 bits (191), Expect = 2e-14 Identities = 52/149 (34%), Positives = 78/149 (52%), Gaps = 2/149 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+A+ GHT+++ LLL + A S G T+LH A +L GAD + Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 + G PL + G ++ LL+ GA V+ +++ TPLH AA+ GH + ++LL+ Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQAAQQGHTHIINVLLQ 782 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310 GA P+A A G T L A + S+ D Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVD 811 Score = 75.9 bits (185), Expect = 8e-14 Identities = 66/234 (28%), Positives = 100/234 (42%), Gaps = 32/234 (13%) Query: 193 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARV 252 G ALH A GH V LL G+ + A + G LH+ G E ++L++ GA + Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123 Query: 253 DGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC----------- 301 + +S + TPL++AA+ H+++ LL GA +G+TPL A Sbjct: 124 NAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182 Query: 302 ---DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ----------RPLHLACR 348 D + + A AR S L D +A Q K PLH+A Sbjct: 183 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242 Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHG 402 G+ V LLL+ G + + G TPLH A + + ++V+ LL+ G Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASK-------RGNTNMVKLLLDRG 289 Score = 70.1 bits (170), Expect = 4e-12 Identities = 53/178 (29%), Positives = 83/178 (46%), Gaps = 15/178 (8%) Query: 182 RRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLEC 241 +RR RP + + L A AG+ V L G D N +Q+G LHL G + Sbjct: 21 QRRKRPKKSDSNASFLR-AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGL 79 Query: 242 AELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC 301 + LL G+ VD + ++ T LH+A+ G E+ +L++ GA +A++ G+TPL A Sbjct: 80 VQELLGRGSSVDS-ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 138 Query: 302 DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 359 + + LL GA+ A +D PL +A ++GH V +LL Sbjct: 139 Q-------------ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183 Score = 48.9 bits (115), Expect = 1e-05 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 1/84 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPL VA G+ +++ LL++ A ++ G T LH+A GHT ++VLL GA PN Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789 Query: 222 ADQDGKRPLHLCRGPGTLECAELL 245 +G L + + G + + L Sbjct: 790 TTANGNTALAIAKRLGYISVVDTL 813 Score = 42.7 bits (99), Expect = 7e-04 Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 7/78 (8%) Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385 L G D + +Q+ LHLA + GH +V+ LL G S ++ G+T LH A Sbjct: 51 LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH------IA 104 Query: 386 ALAQSPEHVVRALLNHGA 403 +LA E VV+ L+ GA Sbjct: 105 SLAGQAE-VVKVLVKEGA 121 >gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] Length = 1897 Score = 122 bits (307), Expect = 5e-28 Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+A+ RG+ ++RLLL R A+ ++ T LH A GH +LL GA Sbjct: 274 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 333 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 ++G P+H+ L+C LLL++ A +D + + TPLHVAA GH +A +LL Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 392 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 +GA P++R G+TPL AC +++ LLL GA DA + Sbjct: 393 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 439 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389 PLH+A GH +V+ LL G S N + TPLH A + +A+ Sbjct: 440 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 487 Score = 120 bits (302), Expect = 2e-27 Identities = 91/266 (34%), Positives = 123/266 (46%), Gaps = 29/266 (10%) Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGAD 218 ++ TPLH+AA GHTEV + LL+ +A+ ++ A +T LH A GHT V +LL A+ Sbjct: 469 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 528 Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278 PN+A G PLH+ G +E LL A ++ TPLHVAA+ G V +A+L Sbjct: 529 PNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAEL 587 Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318 LL R A P+A G TPL A I A Sbjct: 588 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 647 Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378 +++ LL G A+A PLHLA + GHA +V LLLS + N + G TPLH Sbjct: 648 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 707 Query: 379 ALQGPAAALAQSPEHVVRALLNHGAV 404 Q + V L+ HG + Sbjct: 708 VAQ-------EGHVPVADVLIKHGVM 726 Score = 119 bits (297), Expect = 8e-27 Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221 +P+H+AA H + +RLLL+ A D T LH A GH VLL GA PN Sbjct: 340 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 399 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +G PLH+ + ELLL+ GA +D +E TPLHVA+ +GH+ + LL+ Sbjct: 400 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 458 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 RGA P+ N + TPL A A ++ LL A +A +D Q Sbjct: 459 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 505 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 PLH A R GH +V+LLL + N GHTPLH A Sbjct: 506 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 543 Score = 110 bits (275), Expect = 3e-24 Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLHVAA G V LLL R A P++A G T LH A + V +LL G P+ Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +G PLH+ +E A LL++G + S + TPLH+AA+ GH E+ LLL Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 689 Query: 282 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 321 + A + N G TPL + DV + +ATT ++L Sbjct: 690 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 749 Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 LL AD +A + PLH A ++GH +V LLL G S N + G TPL A Sbjct: 750 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807 Score = 101 bits (251), Expect = 2e-21 Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%) Query: 159 EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 188 E+ TPL VA +GH T +LL+ PD Sbjct: 175 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 234 Query: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248 + G T LH A + +LL GA N Q+G PLH+ G + LLL Sbjct: 235 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 294 Query: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 296 GA+++ ++ ++E TPLH AAR GHV ++++LL GA A+ G +P Sbjct: 295 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 353 Query: 297 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 348 LL D IT T A C ++ +LL GA ++ + PLH+AC+ Sbjct: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 413 Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403 + H V+ELLL G S + + G TPLH A+ + P +V+ LL GA Sbjct: 414 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 461 Score = 97.4 bits (241), Expect = 2e-20 Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 T LH+AA G EV+R L+ A ++ + G T L+ A H V LL GA+ N+ Sbjct: 113 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 172 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 A +DG PL + G L+ +G + R LH+AAR A +LL+ Sbjct: 173 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 227 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 PD + G+TPL A L + LLL+ GA + Q+ Sbjct: 228 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 274 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401 PLH+A RRG+ +V LLL G T TPLHCA + +++ LL+H Sbjct: 275 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 327 Query: 402 GA 403 GA Sbjct: 328 GA 329 Score = 85.9 bits (211), Expect = 7e-17 Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+AA GH E++ LLL ++A + G T LH GH VL+ G + Sbjct: 670 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 729 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 + G PLH+ G ++ + LL+ A V+ +++ +PLH AA+ GH ++ LLL+ Sbjct: 730 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 788 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310 GA P+ +++G TPL A + S+TD Sbjct: 789 NGASPNEVSSDGTTPLAIAKRLGYISVTD 817 Score = 61.6 bits (148), Expect = 1e-09 Identities = 42/118 (35%), Positives = 58/118 (49%), Gaps = 2/118 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+ A GH V +L++ D+ G T LH A G+ V LL AD N Sbjct: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 762 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279 + G PLH G + LLL+ GA + S + TPL +A RLG++ + D+L Sbjct: 763 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT-TPLAIAKRLGYISVTDVL 819 Score = 41.2 bits (95), Expect = 0.002 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%) Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385 L G D + +Q+ LHLA + GH +V LL + T G+T LH A Sbjct: 65 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 118 Query: 386 ALAQSPEHVVRALLNHGA 403 ALA E VVR L+N+GA Sbjct: 119 ALAGQDE-VVRELVNYGA 135 >gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] Length = 1881 Score = 122 bits (307), Expect = 5e-28 Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+A+ RG+ ++RLLL R A+ ++ T LH A GH +LL GA Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 ++G P+H+ L+C LLL++ A +D + + TPLHVAA GH +A +LL Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 +GA P++R G+TPL AC +++ LLL GA DA + Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389 PLH+A GH +V+ LL G S N + TPLH A + +A+ Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454 Score = 120 bits (302), Expect = 2e-27 Identities = 91/266 (34%), Positives = 123/266 (46%), Gaps = 29/266 (10%) Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGAD 218 ++ TPLH+AA GHTEV + LL+ +A+ ++ A +T LH A GHT V +LL A+ Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495 Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278 PN+A G PLH+ G +E LL A ++ TPLHVAA+ G V +A+L Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAEL 554 Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318 LL R A P+A G TPL A I A Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614 Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378 +++ LL G A+A PLHLA + GHA +V LLLS + N + G TPLH Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674 Query: 379 ALQGPAAALAQSPEHVVRALLNHGAV 404 Q + V L+ HG + Sbjct: 675 VAQ-------EGHVPVADVLIKHGVM 693 Score = 119 bits (297), Expect = 8e-27 Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221 +P+H+AA H + +RLLL+ A D T LH A GH VLL GA PN Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +G PLH+ + ELLL+ GA +D +E TPLHVA+ +GH+ + LL+ Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 RGA P+ N + TPL A A ++ LL A +A +D Q Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 PLH A R GH +V+LLL + N GHTPLH A Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510 Score = 110 bits (275), Expect = 3e-24 Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLHVAA G V LLL R A P++A G T LH A + V +LL G P+ Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +G PLH+ +E A LL++G + S + TPLH+AA+ GH E+ LLL Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656 Query: 282 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 321 + A + N G TPL + DV + +ATT ++L Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716 Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 LL AD +A + PLH A ++GH +V LLL G S N + G TPL A Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774 Score = 101 bits (251), Expect = 2e-21 Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%) Query: 159 EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 188 E+ TPL VA +GH T +LL+ PD Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201 Query: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248 + G T LH A + +LL GA N Q+G PLH+ G + LLL Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261 Query: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 296 GA+++ ++ ++E TPLH AAR GHV ++++LL GA A+ G +P Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320 Query: 297 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 348 LL D IT T A C ++ +LL GA ++ + PLH+AC+ Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380 Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403 + H V+ELLL G S + + G TPLH A+ + P +V+ LL GA Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428 Score = 97.4 bits (241), Expect = 2e-20 Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 T LH+AA G EV+R L+ A ++ + G T L+ A H V LL GA+ N+ Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 A +DG PL + G L+ +G + R LH+AAR A +LL+ Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 PD + G+TPL A L + LLL+ GA + Q+ Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401 PLH+A RRG+ +V LLL G T TPLHCA + +++ LL+H Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294 Query: 402 GA 403 GA Sbjct: 295 GA 296 Score = 85.9 bits (211), Expect = 7e-17 Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+AA GH E++ LLL ++A + G T LH GH VL+ G + Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 + G PLH+ G ++ + LL+ A V+ +++ +PLH AA+ GH ++ LLL+ Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310 GA P+ +++G TPL A + S+TD Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784 Score = 61.6 bits (148), Expect = 1e-09 Identities = 42/118 (35%), Positives = 58/118 (49%), Gaps = 2/118 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+ A GH V +L++ D+ G T LH A G+ V LL AD N Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279 + G PLH G + LLL+ GA + S + TPL +A RLG++ + D+L Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT-TPLAIAKRLGYISVTDVL 786 Score = 41.2 bits (95), Expect = 0.002 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%) Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385 L G D + +Q+ LHLA + GH +V LL + T G+T LH A Sbjct: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85 Query: 386 ALAQSPEHVVRALLNHGA 403 ALA E VVR L+N+GA Sbjct: 86 ALAGQDE-VVRELVNYGA 102 >gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] Length = 1880 Score = 122 bits (307), Expect = 5e-28 Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+A+ RG+ ++RLLL R A+ ++ T LH A GH +LL GA Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 ++G P+H+ L+C LLL++ A +D + + TPLHVAA GH +A +LL Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 +GA P++R G+TPL AC +++ LLL GA DA + Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389 PLH+A GH +V+ LL G S N + TPLH A + +A+ Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454 Score = 120 bits (302), Expect = 2e-27 Identities = 91/266 (34%), Positives = 123/266 (46%), Gaps = 29/266 (10%) Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGAD 218 ++ TPLH+AA GHTEV + LL+ +A+ ++ A +T LH A GHT V +LL A+ Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495 Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278 PN+A G PLH+ G +E LL A ++ TPLHVAA+ G V +A+L Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAEL 554 Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318 LL R A P+A G TPL A I A Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614 Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378 +++ LL G A+A PLHLA + GHA +V LLLS + N + G TPLH Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674 Query: 379 ALQGPAAALAQSPEHVVRALLNHGAV 404 Q + V L+ HG + Sbjct: 675 VAQ-------EGHVPVADVLIKHGVM 693 Score = 119 bits (297), Expect = 8e-27 Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221 +P+H+AA H + +RLLL+ A D T LH A GH VLL GA PN Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +G PLH+ + ELLL+ GA +D +E TPLHVA+ +GH+ + LL+ Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 RGA P+ N + TPL A A ++ LL A +A +D Q Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 PLH A R GH +V+LLL + N GHTPLH A Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510 Score = 110 bits (275), Expect = 3e-24 Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLHVAA G V LLL R A P++A G T LH A + V +LL G P+ Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +G PLH+ +E A LL++G + S + TPLH+AA+ GH E+ LLL Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656 Query: 282 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 321 + A + N G TPL + DV + +ATT ++L Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716 Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 LL AD +A + PLH A ++GH +V LLL G S N + G TPL A Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774 Score = 101 bits (251), Expect = 2e-21 Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%) Query: 159 EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 188 E+ TPL VA +GH T +LL+ PD Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201 Query: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248 + G T LH A + +LL GA N Q+G PLH+ G + LLL Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261 Query: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 296 GA+++ ++ ++E TPLH AAR GHV ++++LL GA A+ G +P Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320 Query: 297 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 348 LL D IT T A C ++ +LL GA ++ + PLH+AC+ Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380 Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403 + H V+ELLL G S + + G TPLH A+ + P +V+ LL GA Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428 Score = 97.4 bits (241), Expect = 2e-20 Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 T LH+AA G EV+R L+ A ++ + G T L+ A H V LL GA+ N+ Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 A +DG PL + G L+ +G + R LH+AAR A +LL+ Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 PD + G+TPL A L + LLL+ GA + Q+ Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401 PLH+A RRG+ +V LLL G T TPLHCA + +++ LL+H Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294 Query: 402 GA 403 GA Sbjct: 295 GA 296 Score = 85.9 bits (211), Expect = 7e-17 Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+AA GH E++ LLL ++A + G T LH GH VL+ G + Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 + G PLH+ G ++ + LL+ A V+ +++ +PLH AA+ GH ++ LLL+ Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310 GA P+ +++G TPL A + S+TD Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784 Score = 61.6 bits (148), Expect = 1e-09 Identities = 42/118 (35%), Positives = 58/118 (49%), Gaps = 2/118 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+ A GH V +L++ D+ G T LH A G+ V LL AD N Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279 + G PLH G + LLL+ GA + S + TPL +A RLG++ + D+L Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT-TPLAIAKRLGYISVTDVL 786 Score = 41.2 bits (95), Expect = 0.002 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%) Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385 L G D + +Q+ LHLA + GH +V LL + T G+T LH A Sbjct: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85 Query: 386 ALAQSPEHVVRALLNHGA 403 ALA E VVR L+N+GA Sbjct: 86 ALAGQDE-VVRELVNYGA 102 >gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] Length = 1719 Score = 122 bits (307), Expect = 5e-28 Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+A+ RG+ ++RLLL R A+ ++ T LH A GH +LL GA Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 ++G P+H+ L+C LLL++ A +D + + TPLHVAA GH +A +LL Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 +GA P++R G+TPL AC +++ LLL GA DA + Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389 PLH+A GH +V+ LL G S N + TPLH A + +A+ Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454 Score = 120 bits (302), Expect = 2e-27 Identities = 91/266 (34%), Positives = 123/266 (46%), Gaps = 29/266 (10%) Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGAD 218 ++ TPLH+AA GHTEV + LL+ +A+ ++ A +T LH A GHT V +LL A+ Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495 Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278 PN+A G PLH+ G +E LL A ++ TPLHVAA+ G V +A+L Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAEL 554 Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318 LL R A P+A G TPL A I A Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614 Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378 +++ LL G A+A PLHLA + GHA +V LLLS + N + G TPLH Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674 Query: 379 ALQGPAAALAQSPEHVVRALLNHGAV 404 Q + V L+ HG + Sbjct: 675 VAQ-------EGHVPVADVLIKHGVM 693 Score = 119 bits (297), Expect = 8e-27 Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221 +P+H+AA H + +RLLL+ A D T LH A GH VLL GA PN Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +G PLH+ + ELLL+ GA +D +E TPLHVA+ +GH+ + LL+ Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 RGA P+ N + TPL A A ++ LL A +A +D Q Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 PLH A R GH +V+LLL + N GHTPLH A Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510 Score = 110 bits (275), Expect = 3e-24 Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLHVAA G V LLL R A P++A G T LH A + V +LL G P+ Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +G PLH+ +E A LL++G + S + TPLH+AA+ GH E+ LLL Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656 Query: 282 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 321 + A + N G TPL + DV + +ATT ++L Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716 Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 LL AD +A + PLH A ++GH +V LLL G S N + G TPL A Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774 Score = 101 bits (251), Expect = 2e-21 Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%) Query: 159 EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 188 E+ TPL VA +GH T +LL+ PD Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201 Query: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248 + G T LH A + +LL GA N Q+G PLH+ G + LLL Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261 Query: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 296 GA+++ ++ ++E TPLH AAR GHV ++++LL GA A+ G +P Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320 Query: 297 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 348 LL D IT T A C ++ +LL GA ++ + PLH+AC+ Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380 Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403 + H V+ELLL G S + + G TPLH A+ + P +V+ LL GA Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428 Score = 97.4 bits (241), Expect = 2e-20 Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 T LH+AA G EV+R L+ A ++ + G T L+ A H V LL GA+ N+ Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 A +DG PL + G L+ +G + R LH+AAR A +LL+ Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 PD + G+TPL A L + LLL+ GA + Q+ Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401 PLH+A RRG+ +V LLL G T TPLHCA + +++ LL+H Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294 Query: 402 GA 403 GA Sbjct: 295 GA 296 Score = 85.9 bits (211), Expect = 7e-17 Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+AA GH E++ LLL ++A + G T LH GH VL+ G + Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 + G PLH+ G ++ + LL+ A V+ +++ +PLH AA+ GH ++ LLL+ Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310 GA P+ +++G TPL A + S+TD Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784 Score = 61.6 bits (148), Expect = 1e-09 Identities = 42/118 (35%), Positives = 58/118 (49%), Gaps = 2/118 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+ A GH V +L++ D+ G T LH A G+ V LL AD N Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279 + G PLH G + LLL+ GA + S + TPL +A RLG++ + D+L Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT-TPLAIAKRLGYISVTDVL 786 Score = 41.2 bits (95), Expect = 0.002 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%) Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385 L G D + +Q+ LHLA + GH +V LL + T G+T LH A Sbjct: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85 Query: 386 ALAQSPEHVVRALLNHGA 403 ALA E VVR L+N+GA Sbjct: 86 ALAGQDE-VVRELVNYGA 102 >gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] Length = 1856 Score = 122 bits (307), Expect = 5e-28 Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+A+ RG+ ++RLLL R A+ ++ T LH A GH +LL GA Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 ++G P+H+ L+C LLL++ A +D + + TPLHVAA GH +A +LL Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 +GA P++R G+TPL AC +++ LLL GA DA + Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389 PLH+A GH +V+ LL G S N + TPLH A + +A+ Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454 Score = 120 bits (302), Expect = 2e-27 Identities = 91/266 (34%), Positives = 123/266 (46%), Gaps = 29/266 (10%) Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGAD 218 ++ TPLH+AA GHTEV + LL+ +A+ ++ A +T LH A GHT V +LL A+ Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495 Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278 PN+A G PLH+ G +E LL A ++ TPLHVAA+ G V +A+L Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAEL 554 Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318 LL R A P+A G TPL A I A Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614 Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378 +++ LL G A+A PLHLA + GHA +V LLLS + N + G TPLH Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674 Query: 379 ALQGPAAALAQSPEHVVRALLNHGAV 404 Q + V L+ HG + Sbjct: 675 VAQ-------EGHVPVADVLIKHGVM 693 Score = 119 bits (297), Expect = 8e-27 Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221 +P+H+AA H + +RLLL+ A D T LH A GH VLL GA PN Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +G PLH+ + ELLL+ GA +D +E TPLHVA+ +GH+ + LL+ Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 RGA P+ N + TPL A A ++ LL A +A +D Q Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 PLH A R GH +V+LLL + N GHTPLH A Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510 Score = 110 bits (275), Expect = 3e-24 Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLHVAA G V LLL R A P++A G T LH A + V +LL G P+ Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +G PLH+ +E A LL++G + S + TPLH+AA+ GH E+ LLL Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656 Query: 282 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 321 + A + N G TPL + DV + +ATT ++L Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716 Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 LL AD +A + PLH A ++GH +V LLL G S N + G TPL A Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774 Score = 101 bits (251), Expect = 2e-21 Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%) Query: 159 EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 188 E+ TPL VA +GH T +LL+ PD Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201 Query: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248 + G T LH A + +LL GA N Q+G PLH+ G + LLL Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261 Query: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 296 GA+++ ++ ++E TPLH AAR GHV ++++LL GA A+ G +P Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320 Query: 297 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 348 LL D IT T A C ++ +LL GA ++ + PLH+AC+ Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380 Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403 + H V+ELLL G S + + G TPLH A+ + P +V+ LL GA Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428 Score = 97.4 bits (241), Expect = 2e-20 Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 T LH+AA G EV+R L+ A ++ + G T L+ A H V LL GA+ N+ Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 A +DG PL + G L+ +G + R LH+AAR A +LL+ Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 PD + G+TPL A L + LLL+ GA + Q+ Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401 PLH+A RRG+ +V LLL G T TPLHCA + +++ LL+H Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294 Query: 402 GA 403 GA Sbjct: 295 GA 296 Score = 85.9 bits (211), Expect = 7e-17 Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+AA GH E++ LLL ++A + G T LH GH VL+ G + Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 + G PLH+ G ++ + LL+ A V+ +++ +PLH AA+ GH ++ LLL+ Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310 GA P+ +++G TPL A + S+TD Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784 Score = 61.6 bits (148), Expect = 1e-09 Identities = 42/118 (35%), Positives = 58/118 (49%), Gaps = 2/118 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+ A GH V +L++ D+ G T LH A G+ V LL AD N Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279 + G PLH G + LLL+ GA + S + TPL +A RLG++ + D+L Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT-TPLAIAKRLGYISVTDVL 786 Score = 41.2 bits (95), Expect = 0.002 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%) Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385 L G D + +Q+ LHLA + GH +V LL + T G+T LH A Sbjct: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85 Query: 386 ALAQSPEHVVRALLNHGA 403 ALA E VVR L+N+GA Sbjct: 86 ALAGQDE-VVRELVNYGA 102 >gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] Length = 4377 Score = 120 bits (301), Expect = 3e-27 Identities = 83/242 (34%), Positives = 114/242 (47%), Gaps = 22/242 (9%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221 +PLH+A H ++LLL+ D TALH A GH VLL A+PN Sbjct: 336 SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNA 395 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +G PLH+ ++ ELLL+ GA + +E TP+HVAA +GHV + L+ Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGL-TPIHVAAFMGHVNIVSQLMH 454 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 GA P+ N G T L A +A R L+ GA +A +D Q Sbjct: 455 HGASPNTTNVRGETALHMAA-------RSGQAEVVR------YLVQDGAQVEAKAKDDQT 501 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401 PLH++ R G A +V+ LL G S N G+TPLH + + + E V LL+H Sbjct: 502 PLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAR-------EGHEDVAAFLLDH 554 Query: 402 GA 403 GA Sbjct: 555 GA 556 Score = 119 bits (298), Expect = 6e-27 Identities = 83/243 (34%), Positives = 119/243 (48%), Gaps = 24/243 (9%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLHVAA G EV LLL++ A PD+A G T LH A + +LL GA P+ Sbjct: 567 TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA 626 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 A ++G PLH+ ++ A LL +GA + + + + +H+AA+ GHV++ LLL Sbjct: 627 AAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIAS-VHLAAQEGHVDMVSLLLG 685 Query: 282 RGACPDARNAEGWTPL-LAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 340 R A + N G TPL LAA + R + + +L++ GA DA + Sbjct: 686 RNANVNLSNKSGLTPLHLAAQEDR--------------VNVAEVLVNQGAHVDAQTKMGY 731 Query: 341 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN 400 PLH+ C G+ +V LL N G+TPLH A Q Q H++ LL Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQ 784 Query: 401 HGA 403 + A Sbjct: 785 NNA 787 Score = 119 bits (297), Expect = 8e-27 Identities = 84/242 (34%), Positives = 118/242 (48%), Gaps = 22/242 (9%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLHVA+ RG+ +++LLL R A+ D+ G T LH +GH V +LL A Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 ++G PLH+ L C +LLL+ VD + + T LHVAA GH ++A +LL Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVT-NDYLTALHVAAHCGHYKVAKVLLD 388 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 + A P+A+ G+TPL AC +++ LLL GA A + Sbjct: 389 KKANPNAKALNGFTPLHIAC-------------KKNRIKVMELLLKHGASIQAVTESGLT 435 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401 P+H+A GH +V L+ G S NT + G T LH A + A VVR L+ Sbjct: 436 PIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQA-------EVVRYLVQD 488 Query: 402 GA 403 GA Sbjct: 489 GA 490 Score = 118 bits (296), Expect = 1e-26 Identities = 89/262 (33%), Positives = 124/262 (47%), Gaps = 29/262 (11%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 T LH+AA G EV+R L++ A+ ++ A +T LH + G V LL GA PN Sbjct: 468 TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 A G PLHL G + A LL GA + + ++ TPLHVAA+ G +E+A+LLL+ Sbjct: 528 ATTSGYTPLHLSAREGHEDVAAFLLDHGASLS-ITTKKGFTPLHVAAKYGKLEVANLLLQ 586 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSIT----DAEATTARC----------------LQL 321 + A PDA G TPL A Q + D A+ + + Sbjct: 587 KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDI 646 Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381 + LL GADA+A + +HLA + GH +V LLL + N + G TPLH A Q Sbjct: 647 ATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQ 706 Query: 382 GPAAALAQSPEHVVRALLNHGA 403 + +V L+N GA Sbjct: 707 -------EDRVNVAEVLVNQGA 721 Score = 101 bits (251), Expect = 2e-21 Identities = 83/256 (32%), Positives = 118/256 (46%), Gaps = 25/256 (9%) Query: 165 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 223 LH+A+ GH EV+ LL+R A D+A G TALH A AG V VL+ GA+ N Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137 Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRG 283 Q+G PL++ LE + LL GA + E+ TPL VA + GH ++ LLL Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLAVALQQGHDQVVSLLLEND 196 Query: 284 ACPDAR------NAEGWTPLLAACDVRCQSITDAEATTARC----------LQLCSLLLS 327 R A AA ++ + D E+ + + + +LLL+ Sbjct: 197 TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLN 256 Query: 328 AGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAAL 387 A D ++ PLH+A +RG+A +V+LLL G + G TPLHC + Sbjct: 257 RAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGAR------ 310 Query: 388 AQSPEHVVRALLNHGA 403 E VV LL+ A Sbjct: 311 -SGHEQVVEMLLDRAA 325 Score = 94.0 bits (232), Expect = 3e-19 Identities = 79/265 (29%), Positives = 110/265 (41%), Gaps = 31/265 (11%) Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGAD 218 E+ TPL VA +GH +V+ LLL + ALH A T +LL + Sbjct: 171 EDGFTPLAVALQQGHDQVVSLLLENDTK---GKVRLPALHIAARKDDTKAAALLLQNDNN 227 Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278 ++ + G PLH+ G + A LLL A VD + + TPLHVA++ G+ + L Sbjct: 228 ADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVD-FTARNDITPLHVASKRGNANMVKL 286 Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318 LL RGA DA+ +G TPL + + + AT Sbjct: 287 LLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDH 346 Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378 L LLL D D LH+A GH V ++LL + N G TPLH Sbjct: 347 LNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI 406 Query: 379 ALQGPAAALAQSPEHVVRALLNHGA 403 A + ++ V+ LL HGA Sbjct: 407 ACK-------KNRIKVMELLLKHGA 424 Score = 73.6 bits (179), Expect = 4e-13 Identities = 56/179 (31%), Positives = 82/179 (45%), Gaps = 15/179 (8%) Query: 182 RRRARPDSAPGGRTALH-EACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240 R+R+R A + A AGH + G D NI +Q+G LHL G +E Sbjct: 29 RKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88 Query: 241 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 300 LL+ A VD + ++ T LH+A+ G E+ +L+ GA +A++ G+TPL A Sbjct: 89 VVSELLQREANVDA-ATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMA 147 Query: 301 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 359 L++ LL GA A +D PL +A ++GH VV LLL Sbjct: 148 AQ-------------ENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL 193 Score = 68.6 bits (166), Expect = 1e-11 Identities = 47/147 (31%), Positives = 73/147 (49%), Gaps = 2/147 (1%) Query: 165 LHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIAD 223 +H+AA GH +++ LLL R A + S G T LH A VL+ GA + Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 727 Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRG 283 + G PLH+ G ++ LL+ A+V+ +++ TPLH AA+ GH + ++LL+ Sbjct: 728 KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGY-TPLHQAAQQGHTHIINVLLQNN 786 Query: 284 ACPDARNAEGWTPLLAACDVRCQSITD 310 A P+ G T L A + S+ D Sbjct: 787 ASPNELTVNGNTALGIARRLGYISVVD 813 Score = 59.7 bits (143), Expect = 6e-09 Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 23/146 (15%) Query: 264 LHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCS 323 LH+A++ GHVE+ LL+R A DA +G T L A + A ++ Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIA-------------SLAGQAEVVK 124 Query: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 383 +L++ GA+ +A Q+ PL++A + H VV+ LL G S + G TPL Sbjct: 125 VLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPL------- 177 Query: 384 AAALAQSPEHVVRALLNH---GAVRV 406 A AL Q + VV LL + G VR+ Sbjct: 178 AVALQQGHDQVVSLLLENDTKGKVRL 203 Score = 50.8 bits (120), Expect = 3e-06 Identities = 34/127 (26%), Positives = 60/127 (47%), Gaps = 2/127 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLHV G+ +++ LL+ A+ ++ G T LH+A GHT ++VLL A PN Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV-ELADLLL 280 +G L + R G + + L + E+ ++V + V +++D + Sbjct: 792 LTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEV 851 Query: 281 RRGACPD 287 R+ P+ Sbjct: 852 RKANAPE 858 Score = 49.7 bits (117), Expect = 6e-06 Identities = 41/137 (29%), Positives = 63/137 (45%), Gaps = 20/137 (14%) Query: 267 AARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLL 326 AAR GH+E A ++ G + N G L A + +++ S LL Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLA-------------SKEGHVEVVSELL 94 Query: 327 SAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAA 386 A+ DAA + LH+A G A VV++L++ G + N G TPL+ A Q Sbjct: 95 QREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQ----- 149 Query: 387 LAQSPEHVVRALLNHGA 403 ++ VV+ LL++GA Sbjct: 150 --ENHLEVVKFLLDNGA 164 >gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo sapiens] Length = 765 Score = 115 bits (289), Expect = 7e-26 Identities = 82/226 (36%), Positives = 109/226 (48%), Gaps = 17/226 (7%) Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAG 216 E E TPLH+AA V RLL+ R+A P+ G+T LH A GH + V +L G Sbjct: 458 EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG 517 Query: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276 A+ + ++ + PLHL G + + LL+ GA D ++ PLH AA G + Sbjct: 518 AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDAL-DQSGYGPLHTAAARGKYLIC 576 Query: 277 DLLLRRGACPDARNAEGWTPL-LAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAA 335 +LLR GA + +GWTPL LAA L++ LL + A+ A Sbjct: 577 KMLLRYGASLELPTHQGWTPLHLAAYKGH--------------LEIIHLLAESHANMGAL 622 Query: 336 DQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381 PLHLA R G AVV LL CG N + G TPLH A+Q Sbjct: 623 GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQ 668 Score = 114 bits (284), Expect = 3e-25 Identities = 88/246 (35%), Positives = 112/246 (45%), Gaps = 22/246 (8%) Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGA 217 E TPLH ++G E +RLLL D G T L A +LL GA Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419 Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277 D N D+DG PLH G A LLL GA VD + E E TPLH+AA+ +A Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQ-EREGWTPLHLAAQNNFENVAR 478 Query: 278 LLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQ 337 LL+ R A P+ AEG TPL A S L LL S GA+ DA + Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVS-------------LVKLLTSQGAELDAQQR 525 Query: 338 DKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRA 397 + + PLHLA RG ++ LL G + +D G+ PLH A A+ + + Sbjct: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLH-------TAAARGKYLICKM 578 Query: 398 LLNHGA 403 LL +GA Sbjct: 579 LLRYGA 584 Score = 112 bits (280), Expect = 7e-25 Identities = 84/233 (36%), Positives = 112/233 (48%), Gaps = 16/233 (6%) Query: 157 YEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGG-RTALHEACAAGHTACVHVLLVA 215 +E E TPLHVAA GH +++LL + A D+ RT LH A G + LL + Sbjct: 490 HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS 549 Query: 216 GADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVEL 275 GA P+ DQ G PLH G ++LLR+GA ++ + TPLH+AA GH+E+ Sbjct: 550 GAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLE-LPTHQGWTPLHLAAYKGHLEI 608 Query: 276 ADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAA 335 LL A A A WTPL A +++ A LL GAD +AA Sbjct: 609 IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA-------------LLQCGADPNAA 655 Query: 336 DQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH-CALQGPAAAL 387 +Q PLHLA +R V LL + + + G TP H AL+G A L Sbjct: 656 EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAIL 708 Score = 90.1 bits (222), Expect = 4e-18 Identities = 77/218 (35%), Positives = 96/218 (44%), Gaps = 15/218 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPL +AA ++ LLL A + G LH A G +LL GA + Sbjct: 397 TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDA 456 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +++G PLHL A LL+ A E E +TPLHVAA GHV L LL Sbjct: 457 QEREGWTPLHLAAQNNFENVARLLVSRQAD-PNLHEAEGKTPLHVAAYFGHVSLVKLLTS 515 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 +GA DA+ TPL A E R +Q LL +GA DA DQ Sbjct: 516 QGAELDAQQRNLRTPLHLA----------VERGKVRAIQ---HLLKSGAVPDALDQSGYG 562 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 PLH A RG + ++LL G S + G TPLH A Sbjct: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600 Score = 79.7 bits (195), Expect = 5e-15 Identities = 56/147 (38%), Positives = 71/147 (48%), Gaps = 2/147 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+AA +GH E++ LL A + T LH A G A V LL GADPN Sbjct: 595 TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 A+Q G PLHL T LL A V R+ + TP H+AA G+ + +L+ Sbjct: 655 AEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN-KVGWTPAHLAALKGNTAILKVLVE 713 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSI 308 GA D ++ TPL A R Q I Sbjct: 714 AGAQLDVQDGVSCTPLQLALRSRKQGI 740 >gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase [Homo sapiens] Length = 1327 Score = 110 bits (274), Expect = 4e-24 Identities = 85/254 (33%), Positives = 114/254 (44%), Gaps = 23/254 (9%) Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPN 220 ++PLH AA G +V+ LL+ A + GG LH AC+ GH V +LL GADPN Sbjct: 217 SSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPN 276 Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGA-----RVDGRSEEEEETPLHVAARLGHVEL 275 D PLH G ++ +LL+ GA DG+S + P A G + Sbjct: 277 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK 336 Query: 276 ADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC------LQLCSLLLSAG 329 +LL + N E LL +V C + ++T +++ LLL G Sbjct: 337 DELL----EAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHG 392 Query: 330 ADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389 AD A D+ PLH AC GH V ELLL G N MD TPLH A ++ Sbjct: 393 ADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLH-------EAASK 445 Query: 390 SPEHVVRALLNHGA 403 + V LL+HGA Sbjct: 446 NRVEVCSLLLSHGA 459 Score = 92.0 bits (227), Expect = 1e-18 Identities = 76/252 (30%), Positives = 103/252 (40%), Gaps = 19/252 (7%) Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPN 220 +TPLH AA V+ LL A + GG LH AC+ GH +L+ GA N Sbjct: 685 STPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVN 744 Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 280 +AD PLH G E +LLL+ GA + + TPL + G ++ DLL Sbjct: 745 VADLWKFTPLHEAAAKGKYEICKLLLKHGADPT-KKNRDGNTPLDLVKE-GDTDIQDLLR 802 Query: 281 RRGACPDARNAEGWTPLLAAC---DVRCQSITDAEATTARC------LQLCSLLLSAGAD 331 A DA + C ++ C+ +T L++ LL GAD Sbjct: 803 GDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGAD 862 Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391 +A D+ PLH A GH + LL+ N D TPLH A Q + Sbjct: 863 VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQ-------KGR 915 Query: 392 EHVVRALLNHGA 403 + LL HGA Sbjct: 916 TQLCALLLAHGA 927 Score = 89.4 bits (220), Expect = 7e-18 Identities = 74/252 (29%), Positives = 107/252 (42%), Gaps = 40/252 (15%) Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 217 ++ TPLHVAA R H +V+ +L + A+ ++ G+TALH A AGH +LL G+ Sbjct: 556 KDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGS 615 Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277 DP+I G + E + +L E TP+ + D Sbjct: 616 DPSIISLQGFTAAQMGN-----EAVQQIL------------SESTPIRTS---------D 649 Query: 278 LLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC------LQLCSLLLSAGAD 331 + R A + E L ++ +V C+ + +T + + LL GAD Sbjct: 650 VDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGAD 709 Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391 A D+ PLH AC GH V ELL+ G S N D TPLH A A+ Sbjct: 710 VHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLH-------EAAAKGK 762 Query: 392 EHVVRALLNHGA 403 + + LL HGA Sbjct: 763 YEICKLLLKHGA 774 Score = 87.0 bits (214), Expect = 3e-17 Identities = 77/254 (30%), Positives = 109/254 (42%), Gaps = 39/254 (15%) Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNIA 222 PLH A S GH EV LL+R A + A + T LHEA A G +LL GADP Sbjct: 720 PLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKK 779 Query: 223 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGR---------------------SEEEEE 261 ++DG PL L + G + +LL A +D ++ Sbjct: 780 NRDGNTPLDLVK-EGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNS 838 Query: 262 TPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQL 321 TPLH+AA ++E+A+ LL GA +A++ G PL A + + + Sbjct: 839 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPL-------------HNAASYGHVDI 885 Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381 +LL+ +A D+ PLH A ++G + LLL+ G + G TPL A Sbjct: 886 AALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945 Query: 382 GPAAAL---AQSPE 392 AL A PE Sbjct: 946 DDIRALLIDAMPPE 959 Score = 80.9 bits (198), Expect = 2e-15 Identities = 88/282 (31%), Positives = 113/282 (40%), Gaps = 54/282 (19%) Query: 168 AASRGHTEVLRLLLRRRARPDSAPGGR--TALHEACAAGHTACVHVLLVAGADPNIADQD 225 AA G+ E L LL A GR T LH A V +LL GAD + D+ Sbjct: 342 AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKG 401 Query: 226 GKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGAC 285 G PLH G E ELLL+ GA V+ + + TPLH AA VE+ LLL GA Sbjct: 402 GLVPLHNACSYGHYEVTELLLKHGACVNAM-DLWQFTPLHEAASKNRVEVCSLLLSHGAD 460 Query: 286 PDARNAEGW-------TP---------------LLAACDVRCQSI-------------TD 310 P N G TP L AA + + Sbjct: 461 PTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQ 520 Query: 311 AEATTARCL---------QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSC 361 + T C Q+ LLL GA+ + ++D PLH+A R H V+E+L Sbjct: 521 SHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKH 580 Query: 362 GVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403 G N +D G T LH AALA + R LL++G+ Sbjct: 581 GAKMNALDTLGQTALH------RAALAGHLQ-TCRLLLSYGS 615 Score = 53.1 bits (126), Expect = 5e-07 Identities = 44/128 (34%), Positives = 57/128 (44%), Gaps = 13/128 (10%) Query: 260 EETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCL 319 + +PLH AA G ++ + LL+ GA AR+ G PL AC S AE Sbjct: 216 KSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNAC-----SFGHAE------- 263 Query: 320 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 + SLLL GAD +A D PLH A +G V +LL G N + G + L A Sbjct: 264 -VVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA 322 Query: 380 LQGPAAAL 387 A L Sbjct: 323 DPSAKAVL 330 Score = 35.8 bits (81), Expect = 0.087 Identities = 22/56 (39%), Positives = 27/56 (48%) Query: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 L+ +A +A K PLH A G VVE LL G + + D GG PLH A Sbjct: 201 LVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNA 256 >gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens] Length = 2603 Score = 110 bits (274), Expect = 4e-24 Identities = 82/242 (33%), Positives = 116/242 (47%), Gaps = 21/242 (8%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221 TPL AA+ GH ++++LLL +A ++ G TAL ACA G+ V VLL +GA Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +++G PL G +E A LLL GA ++ S E +E+ L +A GH+E+ LL Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 GA + + E T L+ AC D AR LLL +GA + + Sbjct: 423 AGADQEHKTDEMHTALMEAC-------MDGHVEVAR------LLLDSGAQVNMPADSFES 469 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401 PL LA GH + LL+ G S ++ G+TPL A + E +V LL Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPL-------MEAAREGHEEMVALLLGQ 522 Query: 402 GA 403 GA Sbjct: 523 GA 524 Score = 93.2 bits (230), Expect = 5e-19 Identities = 86/264 (32%), Positives = 116/264 (43%), Gaps = 26/264 (9%) Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGA 217 +E+ T L A GH EV RLLL A+ + A + L A GH +L+ GA Sbjct: 432 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491 Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277 + +G PL G E LLL GA ++ ++EE +ET L +A G +E+AD Sbjct: 492 SLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVAD 551 Query: 278 LLLRRGA-------CPDARNA-EGWTPLL-----AACDVRCQSITDAEATTARC----LQ 320 L++ GA P A EG L+ A +V + T A T C Sbjct: 552 FLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTD 611 Query: 321 LCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSAN-TMDYGGHTPLHCA 379 + +LL AGAD + + + PL A R GH V+ L+S G + N T HT L A Sbjct: 612 VADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671 Query: 380 LQGPAAALAQSPEHVVRALLNHGA 403 G A VV LL HGA Sbjct: 672 CAGGHLA-------VVELLLAHGA 688 Score = 92.0 bits (227), Expect = 1e-18 Identities = 63/174 (36%), Positives = 86/174 (49%), Gaps = 15/174 (8%) Query: 195 TALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDG 254 TAL ACA GH V LL GA D+ G PL L G + E+LL GA ++ Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144 Query: 255 RSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT 314 +SE ++TPL +A G E+ +LLL RGA + RN +TPL + A Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL-------------SLAA 1191 Query: 315 TARCLQLCSLLLSAGADADAADQDKQ--RPLHLACRRGHAAVVELLLSCGVSAN 366 + + + +LL+AGA+ ++ K PL LA GH A V+LLL G N Sbjct: 1192 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 1245 Score = 89.7 bits (221), Expect = 5e-18 Identities = 71/200 (35%), Positives = 94/200 (47%), Gaps = 16/200 (8%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA--PGGRTALHEACAAGHTACVHVLLVAGADPN 220 +PL +AA GHT ++LLL + ++ TAL AC G T V +LL A+ Sbjct: 1220 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1279 Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS-EEEEETPLHVAARLGHVELADLL 279 + G PL G E +LL GA V+ +T L +AA GH + +LL Sbjct: 1280 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1339 Query: 280 LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 339 + RGA D RN +G TPL A + L + LL+ AGAD DAAD K Sbjct: 1340 IGRGAHIDVRNKKGNTPLWLAAN-------------GGHLDVVQLLVQAGADVDAADNRK 1386 Query: 340 QRPLHLACRRGHAAVVELLL 359 PL A R+GH VV L+ Sbjct: 1387 ITPLMAAFRKGHVKVVRYLV 1406 Score = 89.0 bits (219), Expect = 9e-18 Identities = 93/274 (33%), Positives = 125/274 (45%), Gaps = 41/274 (14%) Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 217 + +PL +AA GH E+ LL+ R A + G T L EA GH V +LL GA Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524 Query: 218 DPNIADQDGKRP-LHLCRGPGTLECAELLLRFGARVD-GRSEEEEETPLHVAARLGHVEL 275 + N ++ + L L G LE A+ L++ GA ++ G S TPL AA+ GH+EL Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS-----TPLMEAAQEGHLEL 579 Query: 276 ADLLLRRGACPDARNAEGWTPLLAAC--------DVRCQSITDAEATT----------AR 317 LL GA A A G T L AC DV Q+ D E + AR Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639 Query: 318 CLQLCSL--LLSAGADADAADQDKQRP-LHLACRRGHAAVVELLLSCGV-------SANT 367 +C++ L+S GA+ + + L LAC GH AVVELLL+ G +T Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699 Query: 368 M----DYGGHTPLHC-ALQGPAAALAQSPEHVVR 396 M GGHT + C L P L+ P V + Sbjct: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQ 733 Score = 88.2 bits (217), Expect = 1e-17 Identities = 75/249 (30%), Positives = 103/249 (41%), Gaps = 25/249 (10%) Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAG 216 E TPL +A S G EV+ LLL R A + T L A + G+ + +LL AG Sbjct: 1147 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1206 Query: 217 ADPN--IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 274 A+ N + G PL L G +LLL G+ ++ + E T L +A G E Sbjct: 1207 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1266 Query: 275 LADLLLRRGACPDARNAEGWTPLLAAC----------------DVRCQSITDAEATTARC 318 + LLL R A + R G TPL+ A DV + + T Sbjct: 1267 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1326 Query: 319 L------QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGG 372 + C LL+ GA D ++ PL LA GH VV+LL+ G + D Sbjct: 1327 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1386 Query: 373 HTPLHCALQ 381 TPL A + Sbjct: 1387 ITPLMAAFR 1395 Score = 81.6 bits (200), Expect = 1e-15 Identities = 90/310 (29%), Positives = 128/310 (41%), Gaps = 37/310 (11%) Query: 124 TGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEE-------ELTTPLHVAASRGHTEV 176 +G A + T DPE + A + L+ + E+ L + S E Sbjct: 156 SGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEA 215 Query: 177 LRLLLRRRARPDSAPG--GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCR 234 L R RA + G +L EAC+ G V LL+ G N ++G+ L L Sbjct: 216 AAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLAC 275 Query: 235 GPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGW 294 G E A++LL A V+ R + + TPL AA GHV++ LLL A +A+++ G Sbjct: 276 SAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGN 335 Query: 295 TPLLAAC-----DV------RCQSITD---------AEATTARCLQLCSLLLSAGADADA 334 T L AC DV SI D EA +A +++ LLL GA + Sbjct: 336 TALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINT 395 Query: 335 -ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEH 393 +++ K+ L LAC +GH +V LL G HT L A Sbjct: 396 HSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL-------MEACMDGHVE 448 Query: 394 VVRALLNHGA 403 V R LL+ GA Sbjct: 449 VARLLLDSGA 458 Score = 76.3 bits (186), Expect = 6e-14 Identities = 52/153 (33%), Positives = 77/153 (50%), Gaps = 21/153 (13%) Query: 252 VDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA 311 +D ++E +T L +A GH EL LL RGA + R+ +G+TPL+ Sbjct: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLIL------------ 1122 Query: 312 EATTARCLQLCSLLLSAGADADA-ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 370 A TA + + +LL GAD +A +++ K PL LAC G VVELLL+ G + + Sbjct: 1123 -AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 1181 Query: 371 GGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403 +TPL A G ++++ LLN GA Sbjct: 1182 SDYTPLSLAASGGYV-------NIIKILLNAGA 1207 Score = 64.3 bits (155), Expect = 2e-10 Identities = 58/186 (31%), Positives = 87/186 (46%), Gaps = 15/186 (8%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP---GGRTALHEACAAGHTACVHVLLVAGADP 219 TPL AAS G+ EV R+LL + A ++ P TAL A GH +L+ GA Sbjct: 1287 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI 1346 Query: 220 NIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279 ++ ++ G PL L G L+ +LL++ GA VD ++ + TPL A R GHV++ L Sbjct: 1347 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA-ADNRKITPLMAAFRKGHVKVVRYL 1405 Query: 280 LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 339 ++ P + C +ITD E +C LC + D AA+ +K Sbjct: 1406 VKE---------VNQFPSDSECMRYIATITDKE-MLKKC-HLCMESIVQAKDRQAAEANK 1454 Query: 340 QRPLHL 345 + L Sbjct: 1455 NASILL 1460 >gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens] Length = 2352 Score = 110 bits (274), Expect = 4e-24 Identities = 82/242 (33%), Positives = 116/242 (47%), Gaps = 21/242 (8%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221 TPL AA+ GH ++++LLL +A ++ G TAL ACA G+ V VLL +GA Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 +++G PL G +E A LLL GA ++ S E +E+ L +A GH+E+ LL Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 GA + + E T L+ AC D AR LLL +GA + + Sbjct: 423 AGADQEHKTDEMHTALMEAC-------MDGHVEVAR------LLLDSGAQVNMPADSFES 469 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401 PL LA GH + LL+ G S ++ G+TPL A + E +V LL Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPL-------MEAAREGHEEMVALLLGQ 522 Query: 402 GA 403 GA Sbjct: 523 GA 524 Score = 93.2 bits (230), Expect = 5e-19 Identities = 86/264 (32%), Positives = 116/264 (43%), Gaps = 26/264 (9%) Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGA 217 +E+ T L A GH EV RLLL A+ + A + L A GH +L+ GA Sbjct: 432 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491 Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277 + +G PL G E LLL GA ++ ++EE +ET L +A G +E+AD Sbjct: 492 SLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVAD 551 Query: 278 LLLRRGA-------CPDARNA-EGWTPLL-----AACDVRCQSITDAEATTARC----LQ 320 L++ GA P A EG L+ A +V + T A T C Sbjct: 552 FLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTD 611 Query: 321 LCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSAN-TMDYGGHTPLHCA 379 + +LL AGAD + + + PL A R GH V+ L+S G + N T HT L A Sbjct: 612 VADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671 Query: 380 LQGPAAALAQSPEHVVRALLNHGA 403 G A VV LL HGA Sbjct: 672 CAGGHLA-------VVELLLAHGA 688 Score = 92.0 bits (227), Expect = 1e-18 Identities = 63/174 (36%), Positives = 86/174 (49%), Gaps = 15/174 (8%) Query: 195 TALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDG 254 TAL ACA GH V LL GA D+ G PL L G + E+LL GA ++ Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893 Query: 255 RSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT 314 +SE ++TPL +A G E+ +LLL RGA + RN +TPL + A Sbjct: 894 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL-------------SLAA 940 Query: 315 TARCLQLCSLLLSAGADADAADQDKQ--RPLHLACRRGHAAVVELLLSCGVSAN 366 + + + +LL+AGA+ ++ K PL LA GH A V+LLL G N Sbjct: 941 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 994 Score = 89.7 bits (221), Expect = 5e-18 Identities = 71/200 (35%), Positives = 94/200 (47%), Gaps = 16/200 (8%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA--PGGRTALHEACAAGHTACVHVLLVAGADPN 220 +PL +AA GHT ++LLL + ++ TAL AC G T V +LL A+ Sbjct: 969 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1028 Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS-EEEEETPLHVAARLGHVELADLL 279 + G PL G E +LL GA V+ +T L +AA GH + +LL Sbjct: 1029 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1088 Query: 280 LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 339 + RGA D RN +G TPL A + L + LL+ AGAD DAAD K Sbjct: 1089 IGRGAHIDVRNKKGNTPLWLAAN-------------GGHLDVVQLLVQAGADVDAADNRK 1135 Query: 340 QRPLHLACRRGHAAVVELLL 359 PL A R+GH VV L+ Sbjct: 1136 ITPLMAAFRKGHVKVVRYLV 1155 Score = 89.0 bits (219), Expect = 9e-18 Identities = 93/274 (33%), Positives = 125/274 (45%), Gaps = 41/274 (14%) Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 217 + +PL +AA GH E+ LL+ R A + G T L EA GH V +LL GA Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524 Query: 218 DPNIADQDGKRP-LHLCRGPGTLECAELLLRFGARVD-GRSEEEEETPLHVAARLGHVEL 275 + N ++ + L L G LE A+ L++ GA ++ G S TPL AA+ GH+EL Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS-----TPLMEAAQEGHLEL 579 Query: 276 ADLLLRRGACPDARNAEGWTPLLAAC--------DVRCQSITDAEATT----------AR 317 LL GA A A G T L AC DV Q+ D E + AR Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639 Query: 318 CLQLCSL--LLSAGADADAADQDKQRP-LHLACRRGHAAVVELLLSCGV-------SANT 367 +C++ L+S GA+ + + L LAC GH AVVELLL+ G +T Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699 Query: 368 M----DYGGHTPLHC-ALQGPAAALAQSPEHVVR 396 M GGHT + C L P L+ P V + Sbjct: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQ 733 Score = 88.2 bits (217), Expect = 1e-17 Identities = 75/249 (30%), Positives = 103/249 (41%), Gaps = 25/249 (10%) Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAG 216 E TPL +A S G EV+ LLL R A + T L A + G+ + +LL AG Sbjct: 896 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 955 Query: 217 ADPN--IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 274 A+ N + G PL L G +LLL G+ ++ + E T L +A G E Sbjct: 956 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1015 Query: 275 LADLLLRRGACPDARNAEGWTPLLAAC----------------DVRCQSITDAEATTARC 318 + LLL R A + R G TPL+ A DV + + T Sbjct: 1016 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1075 Query: 319 L------QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGG 372 + C LL+ GA D ++ PL LA GH VV+LL+ G + D Sbjct: 1076 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1135 Query: 373 HTPLHCALQ 381 TPL A + Sbjct: 1136 ITPLMAAFR 1144 Score = 81.6 bits (200), Expect = 1e-15 Identities = 90/310 (29%), Positives = 128/310 (41%), Gaps = 37/310 (11%) Query: 124 TGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEE-------ELTTPLHVAASRGHTEV 176 +G A + T DPE + A + L+ + E+ L + S E Sbjct: 156 SGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEA 215 Query: 177 LRLLLRRRARPDSAPG--GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCR 234 L R RA + G +L EAC+ G V LL+ G N ++G+ L L Sbjct: 216 AAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLAC 275 Query: 235 GPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGW 294 G E A++LL A V+ R + + TPL AA GHV++ LLL A +A+++ G Sbjct: 276 SAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGN 335 Query: 295 TPLLAAC-----DV------RCQSITD---------AEATTARCLQLCSLLLSAGADADA 334 T L AC DV SI D EA +A +++ LLL GA + Sbjct: 336 TALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINT 395 Query: 335 -ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEH 393 +++ K+ L LAC +GH +V LL G HT L A Sbjct: 396 HSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL-------MEACMDGHVE 448 Query: 394 VVRALLNHGA 403 V R LL+ GA Sbjct: 449 VARLLLDSGA 458 Score = 76.3 bits (186), Expect = 6e-14 Identities = 52/153 (33%), Positives = 77/153 (50%), Gaps = 21/153 (13%) Query: 252 VDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA 311 +D ++E +T L +A GH EL LL RGA + R+ +G+TPL+ Sbjct: 824 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLIL------------ 871 Query: 312 EATTARCLQLCSLLLSAGADADA-ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 370 A TA + + +LL GAD +A +++ K PL LAC G VVELLL+ G + + Sbjct: 872 -AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 930 Query: 371 GGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403 +TPL A G ++++ LLN GA Sbjct: 931 SDYTPLSLAASGGYV-------NIIKILLNAGA 956 Score = 64.3 bits (155), Expect = 2e-10 Identities = 58/186 (31%), Positives = 87/186 (46%), Gaps = 15/186 (8%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP---GGRTALHEACAAGHTACVHVLLVAGADP 219 TPL AAS G+ EV R+LL + A ++ P TAL A GH +L+ GA Sbjct: 1036 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI 1095 Query: 220 NIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279 ++ ++ G PL L G L+ +LL++ GA VD ++ + TPL A R GHV++ L Sbjct: 1096 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA-ADNRKITPLMAAFRKGHVKVVRYL 1154 Query: 280 LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 339 ++ P + C +ITD E +C LC + D AA+ +K Sbjct: 1155 VKE---------VNQFPSDSECMRYIATITDKE-MLKKC-HLCMESIVQAKDRQAAEANK 1203 Query: 340 QRPLHL 345 + L Sbjct: 1204 NASILL 1209 >gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 [Homo sapiens] Length = 1166 Score = 109 bits (273), Expect = 5e-24 Identities = 84/254 (33%), Positives = 115/254 (45%), Gaps = 23/254 (9%) Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPN 220 +TPLH AA G +V+ LL+ A + GG LH AC+ GH V++LL GADPN Sbjct: 59 STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118 Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGAR-----VDGRSEEEEETPLHVAARLGHVEL 275 D PLH G ++ +LL+ GA DGR+ + P A G + Sbjct: 119 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKK 178 Query: 276 ADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC------LQLCSLLLSAG 329 +LL + N E LL +V C + ++T +++ LLL G Sbjct: 179 DELL----ESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHG 234 Query: 330 ADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389 AD A D+ PLH AC GH V ELL+ G N MD TPLH A ++ Sbjct: 235 ADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLH-------EAASK 287 Query: 390 SPEHVVRALLNHGA 403 + V LL++GA Sbjct: 288 NRVEVCSLLLSYGA 301 Score = 95.1 bits (235), Expect = 1e-19 Identities = 79/248 (31%), Positives = 111/248 (44%), Gaps = 32/248 (12%) Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 217 +E TPLHVA+ + H +V+ ++++ A+ ++ G+T+LH A GH +LL G Sbjct: 398 KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGC 457 Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277 DPNI G L + E + LL+ G + G SE + + L AA+ G VE Sbjct: 458 DPNIISLQGFTALQMGN-----ENVQQLLQEGISL-GNSEADRQ--LLEAAKAGDVETVK 509 Query: 278 LL--LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAA 335 L ++ C D + TPL A S+ + LL GAD A Sbjct: 510 KLCTVQSVNCRDIEGRQS-TPLHFAAGYNRVSVVE-------------YLLQHGADVHAK 555 Query: 336 DQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVV 395 D+ PLH AC GH V ELL+ G N D TPLH A A+ + Sbjct: 556 DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLH-------EAAAKGKYEIC 608 Query: 396 RALLNHGA 403 + LL HGA Sbjct: 609 KLLLQHGA 616 Score = 90.1 bits (222), Expect = 4e-18 Identities = 80/256 (31%), Positives = 108/256 (42%), Gaps = 19/256 (7%) Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAG 216 E +TPLH AA V+ LL+ A + GG LH AC+ GH +L+ G Sbjct: 523 EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 582 Query: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276 A N+AD PLH G E +LLL+ GA + + TPL + + G ++ Sbjct: 583 AVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPT-KKNRDGNTPLDLV-KDGDTDIQ 640 Query: 277 DLLLRRGACPDA--RNAEGWTPLLAACD-VRCQSITDAEATTARC------LQLCSLLLS 327 DLL A DA + L++ D V C+ +T L++ LL Sbjct: 641 DLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQ 700 Query: 328 AGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAAL 387 GAD +A D+ PLH A GH V LL+ N D TPLH A Q Sbjct: 701 HGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQ------ 754 Query: 388 AQSPEHVVRALLNHGA 403 + + LL HGA Sbjct: 755 -KGRTQLCALLLAHGA 769 Score = 85.5 bits (210), Expect = 1e-16 Identities = 73/246 (29%), Positives = 108/246 (43%), Gaps = 36/246 (14%) Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNIA 222 PLH A S GH EV LL++ A + A + T LHEA A G +LL GADP Sbjct: 562 PLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKK 621 Query: 223 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGR---------------------SEEEEE 261 ++DG PL L + G + +LL A +D ++ Sbjct: 622 NRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHS 680 Query: 262 TPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQL 321 TPLH+AA ++E+A+ LL+ GA +A++ G PL A + + + Sbjct: 681 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPL-------------HNAASYGHVDV 727 Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381 +LL+ A +A D+ PLH A ++G + LLL+ G + G TPL Sbjct: 728 AALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787 Query: 382 GPAAAL 387 +AL Sbjct: 788 DDVSAL 793 Score = 72.0 bits (175), Expect = 1e-12 Identities = 75/270 (27%), Positives = 105/270 (38%), Gaps = 46/270 (17%) Query: 155 LTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLL 213 LT E + L A S +++ LL ++ G + T LH A V +LL Sbjct: 172 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLL 231 Query: 214 VAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV 273 GAD + D+ PLH G E ELL++ GA V+ + + TPLH AA V Sbjct: 232 QHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAM-DLWQFTPLHEAASKNRV 290 Query: 274 ELADLLLRRGACPDARNA----------------------EGWTPLLAACDVRCQSI--- 308 E+ LLL GA P N +G + L AA + I Sbjct: 291 EVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKH 350 Query: 309 ----------TDAEATTARCL---------QLCSLLLSAGADADAADQDKQRPLHLACRR 349 T C Q+C LLL GA+ + ++ PLH+A + Sbjct: 351 LSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEK 410 Query: 350 GHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 H VVE+++ N +D G T LH A Sbjct: 411 AHNDVVEVVVKHEAKVNALDNLGQTSLHRA 440 Score = 72.0 bits (175), Expect = 1e-12 Identities = 72/244 (29%), Positives = 99/244 (40%), Gaps = 61/244 (25%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARP--------------------------------DSA 190 TPLH AA++G E+ +LLL+ A P D+A Sbjct: 594 TPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAA 653 Query: 191 PGG-----------------------RTALHEACAAGHTACVHVLLVAGADPNIADQDGK 227 G T LH A + LL GAD N D+ G Sbjct: 654 KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL 713 Query: 228 RPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPD 287 PLH G ++ A LL+++ A V+ +++ TPLH AA+ G +L LLL GA P Sbjct: 714 IPLHNAASYGHVDVAALLIKYNACVNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 772 Query: 288 ARNAEGWTPL-LAACDVRCQSITDAEATTA--RCL--QLCSLLLSAGADADAADQDKQRP 342 +N EG TPL L + D +T A +A C Q+ + + S GA ADA P Sbjct: 773 LKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSP 832 Query: 343 LHLA 346 L+ Sbjct: 833 SSLS 836 >gi|89363047 death-associated protein kinase 1 [Homo sapiens] Length = 1430 Score = 108 bits (271), Expect = 8e-24 Identities = 76/219 (34%), Positives = 108/219 (49%), Gaps = 15/219 (6%) Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPN 220 T PL +AA G+ ++L+LL++R +R D GG A++ A GH + L + Sbjct: 380 TPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLD 439 Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 280 + D+ G+ LH+ G + A+LL FG+ ++EEETPLH AA G+ +A L Sbjct: 440 VKDKSGEMALHVAARYGHADVAQLLCSFGSN-PNIQDKEEETPLHCAAWHGYYSVAKALC 498 Query: 281 RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 340 G + +N EG TPLL A I + L GAD +A D+D Sbjct: 499 EAGCNVNIKNREGETPLLTASARGYHDIVEC-------------LAEHGADLNACDKDGH 545 Query: 341 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 LHLA RR V++ LLS G + D G+TPLH A Sbjct: 546 IALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVA 584 Score = 91.3 bits (225), Expect = 2e-18 Identities = 65/213 (30%), Positives = 97/213 (45%), Gaps = 15/213 (7%) Query: 168 AASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDG 226 AA GH + L+ L + D G ALH A GH +L G++PNI D++ Sbjct: 419 AARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE 478 Query: 227 KRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACP 286 + PLH G A+ L G V+ ++ E ETPL A+ G+ ++ + L GA Sbjct: 479 ETPLHCAAWHGYYSVAKALCEAGCNVNIKN-REGETPLLTASARGYHDIVECLAEHGADL 537 Query: 287 DARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLA 346 +A + +G L A RCQ +++ LLS G D D+ PLH+A Sbjct: 538 NACDKDGHIALHLAVR-RCQ------------MEVIKTLLSQGCFVDYQDRHGNTPLHVA 584 Query: 347 CRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 C+ G+ +V L + + + G TPLH A Sbjct: 585 CKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617 Score = 62.0 bits (149), Expect = 1e-09 Identities = 61/202 (30%), Positives = 80/202 (39%), Gaps = 15/202 (7%) Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAG 216 ++E TPLH AA G+ V + L + G T L A A G+ V L G Sbjct: 475 DKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHG 534 Query: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276 AD N D+DG LHL +E + LL G VD + + TPLHVA + G++ + Sbjct: 535 ADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQ-DRHGNTPLHVACKDGNMPIV 593 Query: 277 DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 336 L D N G TPL A + L + L GA +A Sbjct: 594 VALCEANCNLDISNKYGRTPLHLAAN-------------NGILDVVRYLCLMGASVEALT 640 Query: 337 QDKQRPLHLACRRGHAAVVELL 358 D + LA H V LL Sbjct: 641 TDGKTAEDLARSEQHEHVAGLL 662 Score = 50.8 bits (120), Expect = 3e-06 Identities = 39/118 (33%), Positives = 55/118 (46%), Gaps = 9/118 (7%) Query: 165 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 223 LH+A R EV++ LL + D G T LH AC G+ V L A + +I++ Sbjct: 548 LHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISN 607 Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARV-----DGRSEEE---EETPLHVAARLGHV 273 + G+ PLHL G L+ L GA V DG++ E+ E HVA L + Sbjct: 608 KYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARL 665 >gi|24233530 ankyrin repeat domain 44 [Homo sapiens] Length = 919 Score = 107 bits (266), Expect = 3e-23 Identities = 84/269 (31%), Positives = 122/269 (45%), Gaps = 28/269 (10%) Query: 156 TYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLV 214 T + E TPLHVAA G E++ LL+ AR ++ T LH A A+ V VL+ Sbjct: 11 TLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIK 70 Query: 215 AGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 274 AD N D++ + PLH+ ++CAE+++ + V+ S+ T LH AA GHVE Sbjct: 71 HSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV-SDRGGRTALHHAALNGHVE 129 Query: 275 LADLLLRRGACPDA-----RNAEGWTPLLAACDVRCQSITDAEATTARC----------- 318 + +LLL +GA +A R A W + DV I T + Sbjct: 130 MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAA 189 Query: 319 ----LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHT 374 + + LL+ G + D + LH+AC G AVV L+ G + N + G T Sbjct: 190 SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFT 249 Query: 375 PLHCALQGPAAALAQSPEHVVRALLNHGA 403 PLH A AL + L+N+GA Sbjct: 250 PLHFAAASTHGALC------LELLVNNGA 272 Score = 99.4 bits (246), Expect = 6e-21 Identities = 79/242 (32%), Positives = 113/242 (46%), Gaps = 29/242 (11%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLHVAA+ + +++ + + S GGRTALH A GH V++LL GA+ N Sbjct: 84 TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINA 143 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 D+ +R LH G L+ LL+ GA V + +++ TPLH AA G + + LL Sbjct: 144 FDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK-DKKGYTPLHAAASNGQINVVKHLLN 202 Query: 282 RGACPDARNAEGWTPLLAAC----DVRCQSITD------------------AEATT--AR 317 G D N G T L AC D + D A A+T A Sbjct: 203 LGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL 262 Query: 318 CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377 CL+ LL++ GAD + +D + PLH+ G + L+ G + +D G+TPLH Sbjct: 263 CLE---LLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLH 319 Query: 378 CA 379 A Sbjct: 320 VA 321 Score = 94.4 bits (233), Expect = 2e-19 Identities = 93/297 (31%), Positives = 129/297 (43%), Gaps = 32/297 (10%) Query: 98 GPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPE--RWRDFRFNIRALRLWSL 155 G A A L G V V+ +LA A + FD D W + ++ + L + Sbjct: 114 GGRTALHHAALNGHVEMVNLLLAKG----ANINAFDKKDRRALHWAAYMGHLDVVALL-I 168 Query: 156 TYEEELT-------TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTA 207 + E+T TPLH AAS G V++ LL D G TALH AC G A Sbjct: 169 NHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDA 228 Query: 208 CVHVLLVAGADPNIADQDGKRPLHLCRGP--GTLECAELLLRFGARVDGRSEEEEETPLH 265 V+ L+ GA+ N + +G PLH G L C ELL+ GA V+ +S++ + +PLH Sbjct: 229 VVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL-CLELLVNNGADVNIQSKDGK-SPLH 286 Query: 266 VAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLL 325 + A G + L++ G D + +G TPL A + L + L Sbjct: 287 MTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHEL-------------LINTL 333 Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 382 ++GAD PLHLA H+ LLS G +T D G T LH A G Sbjct: 334 RTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAG 390 Score = 91.7 bits (226), Expect = 1e-18 Identities = 77/239 (32%), Positives = 106/239 (44%), Gaps = 20/239 (8%) Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRAR--PDSAPGG-RTALHEACAAGHTACVHVLLV 214 ++E +H AA+ GH + L LLL R +S G ++ LH A GH + VLL Sbjct: 504 DKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQ 563 Query: 215 AGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 274 + D +I D+ G+ L L G EC E L+ GA + + + TPLH + GH Sbjct: 564 SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTL 623 Query: 275 LADLLLRRGACP---DARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331 LLL P D ++A+G TPL+ A + SLLL A+ Sbjct: 624 CLRLLLEIADNPEAVDVKDAKGQTPLML-------------AVAYGHIDAVSLLLEKEAN 670 Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH-CALQGPAAALAQ 389 D D LH GH V++LL VS D G TPLH A +G A L++ Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSE 729 Score = 81.3 bits (199), Expect = 2e-15 Identities = 66/205 (32%), Positives = 97/205 (47%), Gaps = 28/205 (13%) Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277 D N D + + PLH+ G E ELL+ GARV+ + + TPLH A E Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAK-DNMWLTPLHRAVASRSEEAVQ 66 Query: 278 LLLRRGACPDARNAEGWTPLLAAC---DVRCQ----------SITDAEATTA-------R 317 +L++ A +AR+ TPL A V+C +++D TA Sbjct: 67 VLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNG 126 Query: 318 CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377 +++ +LLL+ GA+ +A D+ +R LH A GH VV LL++ G D G+TPLH Sbjct: 127 HVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLH 186 Query: 378 CALQGPAAALAQSPEHVVRALLNHG 402 AA + +VV+ LLN G Sbjct: 187 -------AAASNGQINVVKHLLNLG 204 Score = 80.5 bits (197), Expect = 3e-15 Identities = 77/269 (28%), Positives = 110/269 (40%), Gaps = 48/269 (17%) Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIA 222 PLH+AA H++ R LL D+ GRT LH A A G+ C+ +L +GAD + Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409 Query: 223 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAAR---------LGHV 273 D+ G+ PLH C E L+ GA V+ +++ T LH AA LG+ Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILGNA 468 Query: 274 E-------------------LADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT 314 + LL+ A P R+ EG+ + A A Sbjct: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYA----------AAYG 518 Query: 315 TARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHT 374 +CL+L ++G + + K PLHLA GH +E+LL V + D G T Sbjct: 519 HRQCLELLLERTNSGFEESDSGATKS-PLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRT 577 Query: 375 PLHCALQGPAAALAQSPEHVVRALLNHGA 403 L A + V AL+N GA Sbjct: 578 ALD-------LAAFKGHTECVEALINPGA 599 Score = 79.3 bits (194), Expect = 7e-15 Identities = 69/202 (34%), Positives = 90/202 (44%), Gaps = 18/202 (8%) Query: 163 TPLHVAASRGH----TEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGAD 218 TPLH AA+RGH +E+L++ L G T LH AC G+ C+ VLL Sbjct: 713 TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCF 772 Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLL-RFGARVDGRSEEEEETPLHVAARLGHVELAD 277 PLH CA LLL + + +++ TPL AA HVE Sbjct: 773 RKFIGNPFT-PLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQ 831 Query: 278 LLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQ 337 LLLR A +A + G T L+ A AE A + + L+ SA AD D+ Sbjct: 832 LLLRHSAPVNAVDNSGKTALMMA----------AENGQAGAVDI--LVNSAQADLTVKDK 879 Query: 338 DKQRPLHLACRRGHAAVVELLL 359 D PLHLAC +GH L+L Sbjct: 880 DLNTPLHLACSKGHEKCALLIL 901 Score = 72.0 bits (175), Expect = 1e-12 Identities = 78/255 (30%), Positives = 104/255 (40%), Gaps = 32/255 (12%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP----GGRTALHEACAAGHTACVHVLLVAGAD 218 TPLH + GHT LRLLL P++ G+T L A A GH V +LL A+ Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670 Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV----E 274 + D G LH G EC ++LL + + + TPLH AA GH E Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYAAARGHATWLSE 729 Query: 275 LADLLLRRGACPDARNAEGWTPLLAAC------------DVRC-QSITDAEATTARCLQL 321 L + L C N +G+TPL AC + +C + T C + Sbjct: 730 LLQMALSEEDCCFKDN-QGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAII 788 Query: 322 -----CSLLLSAGADADAAD--QDKQR-PLHLACRRGHAAVVELLLSCGVSANTMDYGGH 373 C+ LL D+ DK R PL A H ++LLL N +D G Sbjct: 789 NDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK 848 Query: 374 TPLHCALQ-GPAAAL 387 T L A + G A A+ Sbjct: 849 TALMMAAENGQAGAV 863 Score = 48.1 bits (113), Expect = 2e-05 Identities = 27/80 (33%), Positives = 39/80 (48%), Gaps = 7/80 (8%) Query: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 383 +L+ D + D +K+ PLH+A G A ++ELL+ G N D TPLH Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLH------ 54 Query: 384 AAALAQSPEHVVRALLNHGA 403 A+A E V+ L+ H A Sbjct: 55 -RAVASRSEEAVQVLIKHSA 73 Score = 29.3 bits (64), Expect = 8.1 Identities = 11/24 (45%), Positives = 18/24 (75%) Query: 158 EEELTTPLHVAASRGHTEVLRLLL 181 +++L TPLH+A S+GH + L+L Sbjct: 878 DKDLNTPLHLACSKGHEKCALLIL 901 >gi|62988328 ankyrin repeat domain 50 [Homo sapiens] Length = 1429 Score = 105 bits (262), Expect = 9e-23 Identities = 84/242 (34%), Positives = 113/242 (46%), Gaps = 17/242 (7%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPL +AA +GHT+V+ L+ A + G TAL A GHT V LL AG + Sbjct: 580 TPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDC 639 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 AD D + L G + LL+ GA V+ +++ E T L AA +GH E+ + LL Sbjct: 640 ADADSRTALRAAAWGGHEDIVLNLLQHGAEVN-KADNEGRTALIAAAYMGHREIVEHLLD 698 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 GA + + +G T L A C + A+ SLL+ GA+ D D+D Sbjct: 699 HGAEVNHEDVDGRTALSVAA--LCVPASKGHASVV------SLLIDRGAEVDHCDKDGMT 750 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401 PL +A GH VV+LLL G + D G TPL AA + VV LL Sbjct: 751 PLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPL-------LAAASMGHASVVNTLLFW 803 Query: 402 GA 403 GA Sbjct: 804 GA 805 Score = 105 bits (261), Expect = 1e-22 Identities = 90/246 (36%), Positives = 112/246 (45%), Gaps = 27/246 (10%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221 T L AA GHTEV+ LL + D A RTAL A GH V LL GA+ N Sbjct: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARL-----GHVELA 276 AD +G+ L G E E LL GA V+ + + T L VAA GH + Sbjct: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVN-HEDVDGRTALSVAALCVPASKGHASVV 731 Query: 277 DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 336 LL+ RGA D + +G TPLL A + D LLL GAD D D Sbjct: 732 SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVD-------------LLLEGGADVDHTD 778 Query: 337 QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVR 396 + + PL A GHA+VV LL G + +++D G T L + A AQ VVR Sbjct: 779 NNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL-------SIASAQGNVEVVR 831 Query: 397 ALLNHG 402 LL+ G Sbjct: 832 TLLDRG 837 Score = 96.7 bits (239), Expect = 4e-20 Identities = 75/262 (28%), Positives = 119/262 (45%), Gaps = 25/262 (9%) Query: 147 IRALRLWSL---TYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACA 202 + L W + + E T L +A+++G+ EV+R LL R + G T LH A Sbjct: 797 VNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAF 856 Query: 203 AGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEET 262 GH L+ GA N D DG+ P L G +C ++LL + +D R + Sbjct: 857 EGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNA 916 Query: 263 PLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLC 322 L VAA GH ++ +LL GA + ++A+G P L + Q L + Sbjct: 917 -LRVAALEGHRDIVELLFSHGADVNCKDADG-RPTLYILALENQ------------LTMA 962 Query: 323 SLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 382 L GA+ +A+D + + LH++C +GH +V++L++ N D + L Sbjct: 963 EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ----- 1017 Query: 383 PAAALAQSPEHVVRALLNHGAV 404 +A Q VV+ L+ HGAV Sbjct: 1018 --SAAWQGHVKVVQLLIEHGAV 1037 Score = 89.4 bits (220), Expect = 7e-18 Identities = 69/216 (31%), Positives = 101/216 (46%), Gaps = 15/216 (6%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221 TPL VAA GH +V+ LLL A D GRT L A + GH + V+ LL GA + Sbjct: 750 TPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS 809 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 D +G+ L + G +E LL G + R ++ TPLH+AA GH + + L+ Sbjct: 810 IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHR-DDAGWTPLHMAAFEGHRLICEALIE 868 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 +GA + + +G P + A ++ C+Q +LL ++ D D + Sbjct: 869 QGARTNEIDNDGRIPFILA----------SQEGHYDCVQ---ILLENKSNIDQRGYDGRN 915 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377 L +A GH +VELL S G N D G L+ Sbjct: 916 ALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLY 951 Score = 89.0 bits (219), Expect = 9e-18 Identities = 71/246 (28%), Positives = 117/246 (47%), Gaps = 24/246 (9%) Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNIA 222 P +A+ GH + +++LL ++ D GR AL A GH V +L GAD N Sbjct: 883 PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 942 Query: 223 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR 282 D DG+ L++ L AE L GA V+ S+ E T LHV+ GH+E+ +L+ Sbjct: 943 DADGRPTLYILALENQLTMAEYFLENGANVEA-SDAEGRTALHVSCWQGHMEMVQVLIAY 1001 Query: 283 GACPDARNAEGWTPLLAAC---DVRCQSI----------TDAEATTARC-------LQLC 322 A +A + E + L +A V+ + T + TA C + + Sbjct: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVV 1061 Query: 323 SLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 382 +LL GAD + ADQ + + +A + GH+ +++LL G A++++ +P+H Q Sbjct: 1062 QVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG--ASSLNGCSPSPVHTMEQK 1119 Query: 383 PAAALA 388 P +L+ Sbjct: 1120 PLQSLS 1125 Score = 60.8 bits (146), Expect = 3e-09 Identities = 47/147 (31%), Positives = 65/147 (44%), Gaps = 16/147 (10%) Query: 236 PGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWT 295 P E +LL++ GA V+ E++ T V L + LL GA + ++ G T Sbjct: 491 PKEQEVLQLLVKAGAHVNS---EDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRT 547 Query: 296 PLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVV 355 L A A + L + +LL+S GAD + D PL LA R+GH VV Sbjct: 548 LL-------------ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVV 594 Query: 356 ELLLSCGVSANTMDYGGHTPLHCALQG 382 L+ CG + N D G T L A G Sbjct: 595 NCLIGCGANINHTDQDGWTALRSAAWG 621 Score = 37.7 bits (86), Expect = 0.023 Identities = 22/56 (39%), Positives = 32/56 (57%), Gaps = 1/56 (1%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 217 T L +AA GH +V+++LL A P+ A GRTA+ A GH+ + +L GA Sbjct: 1047 TALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102 >gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Homo sapiens] Length = 329 Score = 105 bits (261), Expect = 1e-22 Identities = 95/305 (31%), Positives = 123/305 (40%), Gaps = 50/305 (16%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221 +PLH AAS+G LR LL + ++ T LHEAC H AC LL AGA+ N Sbjct: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 DG PL G+ CAELLL +GA+ + E +P H AA GH E D+L+ Sbjct: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAK--AQLESCLPSPTHEAASKGHHECLDILIS 189 Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341 G D TPL AC ++ LL AGAD + Sbjct: 190 WGIDVDQEIPHLGTPLYVAC-------------MSQQFHCIWKLLYAGADVQKG-KYWDT 235 Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401 PLH A ++ +V LLL G N + P+ +A S V R LL H Sbjct: 236 PLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPID---------VATSSSMVERILLQH 286 Query: 402 GAVRVWPGALPKKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRL 461 A P SL L R +RS++ +P+L LP L Sbjct: 287 EAT------------------------PSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLL 322 Query: 462 LRYLQ 466 +LQ Sbjct: 323 KNFLQ 327 Score = 55.8 bits (133), Expect = 8e-08 Identities = 48/135 (35%), Positives = 64/135 (47%), Gaps = 11/135 (8%) Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAG 216 E L +P H AAS+GH E L +L+ D P T L+ AC + C+ LL AG Sbjct: 165 ESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAG 224 Query: 217 ADPNIADQDGK---RPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV 273 AD Q GK PLH + E LLL FGA ++ ++ E P+ VA V Sbjct: 225 ADV----QKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLR-PIDVATSSSMV 279 Query: 274 ELADLLLRRGACPDA 288 E +LL+ A P + Sbjct: 280 E--RILLQHEATPSS 292 Score = 34.7 bits (78), Expect = 0.19 Identities = 26/91 (28%), Positives = 38/91 (41%), Gaps = 3/91 (3%) Query: 153 WSLTYEEE---LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACV 209 W + ++E L TPL+VA + LL A T LH A T V Sbjct: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIV 249 Query: 210 HVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240 ++LL GAD N + + RP+ + +E Sbjct: 250 NLLLEFGADINAKNTELLRPIDVATSSSMVE 280 >gi|121582655 ankyrin repeat domain 35 [Homo sapiens] Length = 1001 Score = 104 bits (260), Expect = 2e-22 Identities = 81/241 (33%), Positives = 113/241 (46%), Gaps = 21/241 (8%) Query: 149 ALRLWSLTYEEELTTPLHVAASRGHT-EVLRLLLRRRARPDSAPG-GRTALHEACAAGHT 206 A+ W+ ++++L +H RG V L R+ ARP G++ H A + G T Sbjct: 13 AVERWN-RHDQKLLEAVH----RGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLT 67 Query: 207 ACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHV 266 C+ +LL GAD N ++DG LHL +C ++LL+ GA D + E +PLH Sbjct: 68 ECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDA-VDAENRSPLHW 126 Query: 267 AARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLL 326 AA G LL A D + +G TPL+ A + +CS LL Sbjct: 127 AASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIA-------------SLGGHAAICSQLL 173 Query: 327 SAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAA 386 GA + D++ + L LAC +G A V ELLLS G A +D GH LH AL A Sbjct: 174 QRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKA 233 Query: 387 L 387 L Sbjct: 234 L 234 Score = 75.1 bits (183), Expect = 1e-13 Identities = 59/187 (31%), Positives = 82/187 (43%), Gaps = 21/187 (11%) Query: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276 A P D +G+ P HL G EC +LL GA ++ ++E+ T LH+A + Sbjct: 45 ARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGS-TALHLATISCQPQCV 103 Query: 277 DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 336 +LL+ GA DA +AE +PL A C S LL A D D Sbjct: 104 KVLLQHGANEDAVDAENRSPLHWAASSGCASSV-------------LLLCDHEAFLDVLD 150 Query: 337 QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVR 396 D + PL +A GHAA+ LL G N D + L A + +A +A+ Sbjct: 151 NDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAE------- 203 Query: 397 ALLNHGA 403 LL+HGA Sbjct: 204 LLLSHGA 210 >gi|68131557 ankyrin repeat domain 28 [Homo sapiens] Length = 1053 Score = 103 bits (258), Expect = 3e-22 Identities = 82/251 (32%), Positives = 112/251 (44%), Gaps = 22/251 (8%) Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGG-RTALHEACAAGHTACVHVLLVAG 216 + E TPLH AA G E++ LL+ AR ++ T LH A A+ V VLL Sbjct: 38 DNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHS 97 Query: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276 AD N D++ + PLH+ ++CAE L+ + V+ S+ T LH AA GH E+ Sbjct: 98 ADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV-SDRAGRTALHHAAFSGHGEMV 156 Query: 277 DLLLRRGACPDA-----RNAEGWTPLLA-----------ACDVRCQ---SITDAEATTAR 317 LLL RGA +A R A W + +V C+ S T A + Sbjct: 157 KLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASS 216 Query: 318 -CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPL 376 + + LL G D + + PLH+AC G VV L+ CG N + G TPL Sbjct: 217 GMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276 Query: 377 HCALQGPAAAL 387 H A AL Sbjct: 277 HFAAASTHGAL 287 Score = 100 bits (250), Expect = 2e-21 Identities = 78/242 (32%), Positives = 114/242 (47%), Gaps = 29/242 (11%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221 TPLH+AA+ + L+ + + S GRTALH A +GH V +LL GA+ N Sbjct: 109 TPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINA 168 Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281 D+ +R +H G +E +LL+ GA V + +++ TPLH AA G + + LL Sbjct: 169 FDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK-DKKSYTPLHAAASSGMISVVKYLLD 227 Query: 282 RGACPDARNAEGWTPLLAAC----DVRCQSITD------------------AEATT--AR 317 G + NA G TPL AC DV + D A A+T A Sbjct: 228 LGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL 287 Query: 318 CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377 CL+ LL+ GAD + +D + PLH+ G + + ++ G + D G+TPLH Sbjct: 288 CLE---LLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLH 344 Query: 378 CA 379 A Sbjct: 345 IA 346 Score = 98.6 bits (244), Expect = 1e-20 Identities = 81/255 (31%), Positives = 114/255 (44%), Gaps = 44/255 (17%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-----GGRTALHEACAAGHTACVHVLLVAGA 217 TP+H AA+ GH+E LRLL+ A P +A G+T L + GHT CV+ LL GA Sbjct: 619 TPIHAAATNGHSECLRLLIGN-AEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA 677 Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277 + + D+ G+ LH G EC + LL+ GA+ R + TP+H++A GH+ + Sbjct: 678 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLR-DSRGRTPIHLSAACGHIGVLG 736 Query: 278 LLLRRGACPDARNA----EGWTPLLAAC--------------------------DVRCQS 307 LL+ A DA A G+T L AC + C Sbjct: 737 ALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAV 796 Query: 308 ITDAEATTARCLQLCSLLLSAGAD-ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSAN 366 I D E L+ + GA +A D + PLH A H ++LLLS N Sbjct: 797 INDNEGAAE------MLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850 Query: 367 TMDYGGHTPLHCALQ 381 ++D G TPL A + Sbjct: 851 SVDSTGKTPLMMAAE 865 Score = 91.3 bits (225), Expect = 2e-18 Identities = 81/248 (32%), Positives = 112/248 (45%), Gaps = 32/248 (12%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-----GRTALHEACAAGHTACVHVLLVAGA 217 TP+H++A+ GH VL LL+ A D+ P G TALH AC GH CV +LL Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV 780 Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLL-RFGARVDGRSEEEEETPLHVAARLGHVELA 276 + + PLH AE+L+ GA + ++ + TPLH AA HVE Sbjct: 781 FQK-TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECL 839 Query: 277 DLLLRRGACPDARNAEGWTPLLAACD---VRCQSITDAEATTARCLQ----------LCS 323 LLL A ++ ++ G TPL+ A + + + A+ LQ CS Sbjct: 840 QLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACS 899 Query: 324 --------LLLSAGADAD---AADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGG 372 L+L D + A + Q PLH+A R G VV+ LL G S +D G Sbjct: 900 KGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENG 959 Query: 373 HTP-LHCA 379 +TP L CA Sbjct: 960 YTPALACA 967 Score = 86.7 bits (213), Expect = 4e-17 Identities = 81/249 (32%), Positives = 117/249 (46%), Gaps = 25/249 (10%) Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIA 222 PLH+AA G ++ R LL D+ GRT LH A A G+ C+++LL GAD N Sbjct: 375 PLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKK 434 Query: 223 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLG-HVELADLLLR 281 D+ G+ PLH +C L+ GA V+ +E TPLH AA + + LLR Sbjct: 435 DKFGRSPLHYAAANCNYQCLFALVGSGASVND-LDERGCTPLHYAATSDTDGKCLEYLLR 493 Query: 282 RGACPDARNAEGWTPL--LAACDVR-CQSITDAEATTARCLQLCSLLLSAGAD--ADAAD 336 A P R+ +G+ + AA R C + +E L L+ ++G D +D+ + Sbjct: 494 NDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASET------PLDVLMETSGTDMLSDSDN 547 Query: 337 QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHV-- 394 + PLHLA GH +E+L+ + + + G TPL LA HV Sbjct: 548 RATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLD---------LAAFKGHVEC 598 Query: 395 VRALLNHGA 403 V L+N GA Sbjct: 599 VDVLINQGA 607 Score = 85.1 bits (209), Expect = 1e-16 Identities = 83/262 (31%), Positives = 107/262 (40%), Gaps = 61/262 (23%) Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHV---------- 211 +PLH+AA GH + L +L++ D GRT L A GH CV V Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611 Query: 212 -----------------------LLVAGADP----NIADQDGKRPLHLCRGPGTLECAEL 244 LL+ A+P +I D +G+ PL L G +C Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671 Query: 245 LLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP--LLAACD 302 LL GA VD + ++ T LH A GH E D LL+ GA R++ G TP L AAC Sbjct: 672 LLNKGANVDAK-DKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730 Query: 303 VRCQSITDAEATTARCLQLCSLLLSAGADADA----ADQDKQRPLHLACRRGHAAVVELL 358 + + LL + A DA AD LH AC GH VELL Sbjct: 731 ---------------HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775 Query: 359 LSCGVSANTMDYGGHTPLHCAL 380 L V T + +PLHCA+ Sbjct: 776 LEQEVFQKT-EGNAFSPLHCAV 796 Score = 82.0 bits (201), Expect = 1e-15 Identities = 68/219 (31%), Positives = 103/219 (47%), Gaps = 25/219 (11%) Query: 194 RTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVD 253 RT LH A G + +L+++GA N D PLH + E ++LL+ A V+ Sbjct: 42 RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN 101 Query: 254 GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA-- 311 R ++ +TPLH+AA V+ A+ L+ PLL+ +V ++ A Sbjct: 102 AR-DKNWQTPLHIAAANKAVKCAEALV---------------PLLSNVNVSDRAGRTALH 145 Query: 312 EATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYG 371 A + ++ LLLS GA+ +A D+ +R +H A GH VV+LL+S G D Sbjct: 146 HAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKK 205 Query: 372 GHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGA 410 +TPLH AA + VV+ LL+ G P A Sbjct: 206 SYTPLH-------AAASSGMISVVKYLLDLGVDMNEPNA 237 Score = 78.6 bits (192), Expect = 1e-14 Identities = 61/201 (30%), Positives = 88/201 (43%), Gaps = 20/201 (9%) Query: 197 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS 256 LH A GH + VL+ + D ++ + G+ PL L G +EC ++L+ GA + + Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613 Query: 257 EEEEETPLHVAARLGHVELADLLLRRGA---CPDARNAEGWTPLLAACDVRCQSITDAEA 313 + TP+H AA GH E LL+ D ++ G TPL+ + TD Sbjct: 614 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSV---LNGHTDCVY 670 Query: 314 TTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGH 373 + LL+ GA+ DA D+ + LH GH V+ LL G D G Sbjct: 671 S----------LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720 Query: 374 TPLH----CALQGPAAALAQS 390 TP+H C G AL QS Sbjct: 721 TPIHLSAACGHIGVLGALLQS 741 Score = 47.0 bits (110), Expect = 4e-05 Identities = 27/73 (36%), Positives = 35/73 (47%), Gaps = 7/73 (9%) Query: 331 DADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQS 390 D + D +K+ PLH A G A ++ELL+ G N D TPLH A+A Sbjct: 33 DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLH-------RAVASC 85 Query: 391 PEHVVRALLNHGA 403 E V+ LL H A Sbjct: 86 SEEAVQVLLKHSA 98 >gi|18079216 CASK interacting protein 1 [Homo sapiens] Length = 1431 Score = 103 bits (257), Expect = 3e-22 Identities = 75/212 (35%), Positives = 108/212 (50%), Gaps = 14/212 (6%) Query: 191 PGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGA 250 P G +ALH A G+T + +LL A A +I D G RPLH G E +L+L+ G+ Sbjct: 47 PDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGS 106 Query: 251 RVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITD 310 V+ S +E PLH+AA+ GH +++++LL+ + P + G TPL AC+ + Sbjct: 107 AVNIPS-DEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQ 165 Query: 311 AEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 370 ++ +C+ LL DA D + PLHLA + GH ++ LLL G+ N Sbjct: 166 LLLSS----NMCAALLEP-RPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTK 220 Query: 371 GGHTPLHCALQGPAAALAQSPEHVVRALLNHG 402 G T LH AAL E VVR LL+ G Sbjct: 221 SG-TALH------EAALCGKTE-VVRLLLDSG 244 Score = 65.9 bits (159), Expect = 8e-11 Identities = 49/143 (34%), Positives = 67/143 (46%), Gaps = 11/143 (7%) Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLL-----VAGA 217 PLH+AA GH +V +LL+ ++ P G+T L AC G V +LL A Sbjct: 118 PLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALL 177 Query: 218 DP---NIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 274 +P + D +G PLHL G ++ LLL+ G +D + + T LH AA G E Sbjct: 178 EPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAG--IDINRQTKSGTALHEAALCGKTE 235 Query: 275 LADLLLRRGACPDARNAEGWTPL 297 + LLL G RN T L Sbjct: 236 VVRLLLDSGINAHVRNTYSQTAL 258 Score = 48.5 bits (114), Expect = 1e-05 Identities = 24/60 (40%), Positives = 36/60 (60%) Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221 T+PLH+AA GH +++RLLL+ + TALHEA G T V +LL +G + ++ Sbjct: 190 TSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHV 249 Score = 40.0 bits (92), Expect = 0.005 Identities = 35/103 (33%), Positives = 43/103 (41%), Gaps = 10/103 (9%) Query: 163 TPLHVAASRGHTEVLRLLLRRRA-------RPDSA--PGGRTALHEACAAGHTACVHVLL 213 TPL +A G V++LLL RP A P G + LH A GH + +LL Sbjct: 150 TPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLL 209 Query: 214 VAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS 256 AG D N + G LH G E LLL G R+ Sbjct: 210 QAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRN 251 >gi|156142199 euchromatic histone-lysine N-methyltransferase 2 isoform b [Homo sapiens] Length = 1176 Score = 103 bits (257), Expect = 3e-22 Identities = 98/354 (27%), Positives = 151/354 (42%), Gaps = 62/354 (17%) Query: 32 AYTSPPPHSP-FPAHMLMSWSPEECKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGP 90 A +PPP S P S +G GEP R P C L + Sbjct: 527 AAPAPPPLSQDVPGRADTSQPSARMRGHGEP---RRPPCDPLAD---------------- 567 Query: 91 IVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGL-APDSVFDTSDPERWRDFRFNIRA 149 T +SGP+L GC+S + G A + + ER + RF+ R Sbjct: 568 --TIDSSGPSLTLPNG------GCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQ 619 Query: 150 LRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPD---SAPGGRTALHEACAAGHT 206 L +++ +G + + L+L P+ RT LH A G Sbjct: 620 L---------------YLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSV 664 Query: 207 ACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHV 266 HVLL AGA+ N D+ + PL LE A +++ G V + EE+ T LH Sbjct: 665 EICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK-EEDGSTCLHH 723 Query: 267 AARLGHVELADLLLRRGACP-DARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLL 325 AA++G++E+ LLL G +A+++ GWTP++ A + + +++ +L Sbjct: 724 AAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAE-------------HKHIEVIRML 770 Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 L+ GAD D ++ LH A G AA+ E+LL+ + ++Y G TPLH A Sbjct: 771 LTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 824 Score = 66.6 bits (161), Expect = 5e-11 Identities = 52/141 (36%), Positives = 71/141 (50%), Gaps = 5/141 (3%) Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP--GGRTALHEACAAGHTACVHVLLVA 215 EE+ +T LH AA G+ E++ LLL +A GG T + A H + +LL Sbjct: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773 Query: 216 GADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEE-ETPLHVAARLGHVE 274 GAD + D + LH G+ AE+LL AR D + +TPLH+AAR + + Sbjct: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLN--ARCDLHAVNYHGDTPLHIAARESYHD 831 Query: 275 LADLLLRRGACPDARNAEGWT 295 L L RGA P+ RN EG T Sbjct: 832 CVLLFLSRGANPELRNKEGDT 852 >gi|156142197 euchromatic histone-lysine N-methyltransferase 2 isoform a [Homo sapiens] Length = 1210 Score = 103 bits (257), Expect = 3e-22 Identities = 98/354 (27%), Positives = 151/354 (42%), Gaps = 62/354 (17%) Query: 32 AYTSPPPHSP-FPAHMLMSWSPEECKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGP 90 A +PPP S P S +G GEP R P C L + Sbjct: 561 AAPAPPPLSQDVPGRADTSQPSARMRGHGEP---RRPPCDPLAD---------------- 601 Query: 91 IVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGL-APDSVFDTSDPERWRDFRFNIRA 149 T +SGP+L GC+S + G A + + ER + RF+ R Sbjct: 602 --TIDSSGPSLTLPNG------GCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQ 653 Query: 150 LRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPD---SAPGGRTALHEACAAGHT 206 L +++ +G + + L+L P+ RT LH A G Sbjct: 654 L---------------YLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSV 698 Query: 207 ACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHV 266 HVLL AGA+ N D+ + PL LE A +++ G V + EE+ T LH Sbjct: 699 EICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK-EEDGSTCLHH 757 Query: 267 AARLGHVELADLLLRRGACP-DARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLL 325 AA++G++E+ LLL G +A+++ GWTP++ A + + +++ +L Sbjct: 758 AAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAE-------------HKHIEVIRML 804 Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379 L+ GAD D ++ LH A G AA+ E+LL+ + ++Y G TPLH A Sbjct: 805 LTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 858 Score = 66.6 bits (161), Expect = 5e-11 Identities = 52/141 (36%), Positives = 71/141 (50%), Gaps = 5/141 (3%) Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP--GGRTALHEACAAGHTACVHVLLVA 215 EE+ +T LH AA G+ E++ LLL +A GG T + A H + +LL Sbjct: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807 Query: 216 GADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEE-ETPLHVAARLGHVE 274 GAD + D + LH G+ AE+LL AR D + +TPLH+AAR + + Sbjct: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLN--ARCDLHAVNYHGDTPLHIAARESYHD 865 Query: 275 LADLLLRRGACPDARNAEGWT 295 L L RGA P+ RN EG T Sbjct: 866 CVLLFLSRGANPELRNKEGDT 886 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.136 0.430 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 21,872,311 Number of Sequences: 37866 Number of extensions: 1117158 Number of successful extensions: 8655 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 352 Number of HSP's successfully gapped in prelim test: 35 Number of HSP's that attempted gapping in prelim test: 3088 Number of HSP's gapped (non-prelim): 2048 length of query: 474 length of database: 18,247,518 effective HSP length: 106 effective length of query: 368 effective length of database: 14,233,722 effective search space: 5238009696 effective search space used: 5238009696 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.