Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 21536371
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21536371 telomerase-associated protein 1 [Homo sapiens]
(2627 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 5287 0.0
gi|19913369 transducin beta-like 3 [Homo sapiens] 109 4e-23
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 105 6e-22
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 105 6e-22
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 103 3e-21
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 99 6e-20
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 88 1e-16
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 88 1e-16
gi|26665869 WD repeat domain 51B [Homo sapiens] 88 1e-16
gi|157266266 WD repeat domain 86 [Homo sapiens] 87 2e-16
gi|189571685 WD repeat, sterile alpha motif and U-box domain con... 87 3e-16
gi|189571683 WD repeat, sterile alpha motif and U-box domain con... 87 3e-16
gi|189571681 WD repeat, sterile alpha motif and U-box domain con... 87 3e-16
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 86 5e-16
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 86 5e-16
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 86 5e-16
gi|16554629 WD repeat domain 5 [Homo sapiens] 85 8e-16
gi|16554627 WD repeat domain 5 [Homo sapiens] 85 8e-16
gi|32189425 WD repeat domain 69 [Homo sapiens] 84 1e-15
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 83 4e-15
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 83 4e-15
gi|19913367 transducin beta-like 1Y [Homo sapiens] 83 4e-15
gi|19913365 transducin beta-like 1Y [Homo sapiens] 83 4e-15
gi|15150805 transducin beta-like 1Y [Homo sapiens] 83 4e-15
gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo s... 82 9e-15
gi|113865883 WD repeat domain 38 [Homo sapiens] 81 2e-14
gi|23199987 WD repeat domain 5B [Homo sapiens] 81 2e-14
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 80 2e-14
gi|89886480 zinedin isoform 2 [Homo sapiens] 78 1e-13
gi|89886477 zinedin isoform 1 [Homo sapiens] 78 1e-13
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 5287 bits (13714), Expect = 0.0
Identities = 2627/2627 (100%), Positives = 2627/2627 (100%)
Query: 1 MEKLHGHVSAHPDILSLENRCLAMLPDLQPLEKLHQHVSTHSDILSLKNQCLATLPDLKT 60
MEKLHGHVSAHPDILSLENRCLAMLPDLQPLEKLHQHVSTHSDILSLKNQCLATLPDLKT
Sbjct: 1 MEKLHGHVSAHPDILSLENRCLAMLPDLQPLEKLHQHVSTHSDILSLKNQCLATLPDLKT 60
Query: 61 MEKPHGYVSAHPDILSLENQCLATLSDLKTMEKPHGHVSAHPDILSLENRCLATLSSLKS 120
MEKPHGYVSAHPDILSLENQCLATLSDLKTMEKPHGHVSAHPDILSLENRCLATLSSLKS
Sbjct: 61 MEKPHGYVSAHPDILSLENQCLATLSDLKTMEKPHGHVSAHPDILSLENRCLATLSSLKS 120
Query: 121 TVSASPLFQSLQISHMTQADLYRVNNSNCLLSEPPSWRAQHFSKGLDLSTCPIALKSISA 180
TVSASPLFQSLQISHMTQADLYRVNNSNCLLSEPPSWRAQHFSKGLDLSTCPIALKSISA
Sbjct: 121 TVSASPLFQSLQISHMTQADLYRVNNSNCLLSEPPSWRAQHFSKGLDLSTCPIALKSISA 180
Query: 181 TETAQEATLGRWFDSEEKKGAETQMPSYSLSLGEEEEVEDLAVKLTSGDSESHPEPTDHV 240
TETAQEATLGRWFDSEEKKGAETQMPSYSLSLGEEEEVEDLAVKLTSGDSESHPEPTDHV
Sbjct: 181 TETAQEATLGRWFDSEEKKGAETQMPSYSLSLGEEEEVEDLAVKLTSGDSESHPEPTDHV 240
Query: 241 LQEKKMALLSLLCSTLVSEVNMNNTSDPTLAAIFEICRELALLEPEFILKASLYARQQLN 300
LQEKKMALLSLLCSTLVSEVNMNNTSDPTLAAIFEICRELALLEPEFILKASLYARQQLN
Sbjct: 241 LQEKKMALLSLLCSTLVSEVNMNNTSDPTLAAIFEICRELALLEPEFILKASLYARQQLN 300
Query: 301 VRNVANNILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGDKNKLVPLPAC 360
VRNVANNILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGDKNKLVPLPAC
Sbjct: 301 VRNVANNILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGDKNKLVPLPAC 360
Query: 361 LRTAMTDKFAQFDEYQLAKYNPRKHRAKRHPRRPPRSPGMEPPFSHRCFPRYIGFLREEQ 420
LRTAMTDKFAQFDEYQLAKYNPRKHRAKRHPRRPPRSPGMEPPFSHRCFPRYIGFLREEQ
Sbjct: 361 LRTAMTDKFAQFDEYQLAKYNPRKHRAKRHPRRPPRSPGMEPPFSHRCFPRYIGFLREEQ 420
Query: 421 RKFEKAGDTVSEKKNPPRFTLKKLVQRLHIHKPAQHVQALLGYRYPSNLQLFSRSRLPGP 480
RKFEKAGDTVSEKKNPPRFTLKKLVQRLHIHKPAQHVQALLGYRYPSNLQLFSRSRLPGP
Sbjct: 421 RKFEKAGDTVSEKKNPPRFTLKKLVQRLHIHKPAQHVQALLGYRYPSNLQLFSRSRLPGP 480
Query: 481 WDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISS 540
WDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISS
Sbjct: 481 WDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISS 540
Query: 541 RHHELILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNQALPFPSNITLMRRILTR 600
RHHELILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNQALPFPSNITLMRRILTR
Sbjct: 541 RHHELILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNQALPFPSNITLMRRILTR 600
Query: 601 NEKNRPRRRFLCHLSRQQLRMAMRIPVLYEQLKREKLRVHKARQWKYDGEMLNRYRQALE 660
NEKNRPRRRFLCHLSRQQLRMAMRIPVLYEQLKREKLRVHKARQWKYDGEMLNRYRQALE
Sbjct: 601 NEKNRPRRRFLCHLSRQQLRMAMRIPVLYEQLKREKLRVHKARQWKYDGEMLNRYRQALE 660
Query: 661 TAVNLSVKHSLPLLPGRTVLVYLTDANADRLCPKSNPQGPPLNYALLLIGMMITRAEQVD 720
TAVNLSVKHSLPLLPGRTVLVYLTDANADRLCPKSNPQGPPLNYALLLIGMMITRAEQVD
Sbjct: 661 TAVNLSVKHSLPLLPGRTVLVYLTDANADRLCPKSNPQGPPLNYALLLIGMMITRAEQVD 720
Query: 721 VVLCGGDTLKTAVLKAEEGILKTAIKLQAQVQEFDENDGWSLNTFGKYLLSLAGQRVPVD 780
VVLCGGDTLKTAVLKAEEGILKTAIKLQAQVQEFDENDGWSLNTFGKYLLSLAGQRVPVD
Sbjct: 721 VVLCGGDTLKTAVLKAEEGILKTAIKLQAQVQEFDENDGWSLNTFGKYLLSLAGQRVPVD 780
Query: 781 RVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQYLSTDLNPNDVTLSGCTDAI 840
RVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQYLSTDLNPNDVTLSGCTDAI
Sbjct: 781 RVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQYLSTDLNPNDVTLSGCTDAI 840
Query: 841 LKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLAPVSQQGWRSIR 900
LKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLAPVSQQGWRSIR
Sbjct: 841 LKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLAPVSQQGWRSIR 900
Query: 901 LFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHGIDLRWGVTEEETRRNRQLEVCL 960
LFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHGIDLRWGVTEEETRRNRQLEVCL
Sbjct: 901 LFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHGIDLRWGVTEEETRRNRQLEVCL 960
Query: 961 GEVENAQLFVGILGSRYGYIPPSYNLPDHPHFHWAQQYPSGRSVTEMEVMQFLNRNQRLQ 1020
GEVENAQLFVGILGSRYGYIPPSYNLPDHPHFHWAQQYPSGRSVTEMEVMQFLNRNQRLQ
Sbjct: 961 GEVENAQLFVGILGSRYGYIPPSYNLPDHPHFHWAQQYPSGRSVTEMEVMQFLNRNQRLQ 1020
Query: 1021 PSAQALIYFRDSSFLSSVPDAWKSDFVSESEEAARRISELKSYLSRQKGITCRRYPCEWG 1080
PSAQALIYFRDSSFLSSVPDAWKSDFVSESEEAARRISELKSYLSRQKGITCRRYPCEWG
Sbjct: 1021 PSAQALIYFRDSSFLSSVPDAWKSDFVSESEEAARRISELKSYLSRQKGITCRRYPCEWG 1080
Query: 1081 GVAAGRPYVGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDLVQATFQQLQKP 1140
GVAAGRPYVGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDLVQATFQQLQKP
Sbjct: 1081 GVAAGRPYVGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDLVQATFQQLQKP 1140
Query: 1141 PSPARPRLLQDTVQRLMLPHGRLSLVTGQSGQGKTAFLASLVSALQAPDGAKVASLVFFH 1200
PSPARPRLLQDTVQRLMLPHGRLSLVTGQSGQGKTAFLASLVSALQAPDGAKVASLVFFH
Sbjct: 1141 PSPARPRLLQDTVQRLMLPHGRLSLVTGQSGQGKTAFLASLVSALQAPDGAKVASLVFFH 1200
Query: 1201 FSGARPDQGLALTLLRRLCTYLRGQLKEPGALPSTYRSLVWELQQRLLPKSAESLHPGQT 1260
FSGARPDQGLALTLLRRLCTYLRGQLKEPGALPSTYRSLVWELQQRLLPKSAESLHPGQT
Sbjct: 1201 FSGARPDQGLALTLLRRLCTYLRGQLKEPGALPSTYRSLVWELQQRLLPKSAESLHPGQT 1260
Query: 1261 QVLIIDGADRLVDQNGQLISDWIPKKLPRCVHLVLSVSSDAGLGETLEQSQGAHVLALGP 1320
QVLIIDGADRLVDQNGQLISDWIPKKLPRCVHLVLSVSSDAGLGETLEQSQGAHVLALGP
Sbjct: 1261 QVLIIDGADRLVDQNGQLISDWIPKKLPRCVHLVLSVSSDAGLGETLEQSQGAHVLALGP 1320
Query: 1321 LEASARARLVREELALYGKRLEESPFNNQMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQ 1380
LEASARARLVREELALYGKRLEESPFNNQMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQ
Sbjct: 1321 LEASARARLVREELALYGKRLEESPFNNQMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQ 1380
Query: 1381 VSERLRTLPATVPLLLQHILSTLEKEHGPDVLPQALTALEVTRSGLTVDQLHGVLSVWRT 1440
VSERLRTLPATVPLLLQHILSTLEKEHGPDVLPQALTALEVTRSGLTVDQLHGVLSVWRT
Sbjct: 1381 VSERLRTLPATVPLLLQHILSTLEKEHGPDVLPQALTALEVTRSGLTVDQLHGVLSVWRT 1440
Query: 1441 LPKGTKSWEEAVAAGNSGDPYPMGPFACLVQSLRSLLGEGPLERPGARLCLPDGPLRTAA 1500
LPKGTKSWEEAVAAGNSGDPYPMGPFACLVQSLRSLLGEGPLERPGARLCLPDGPLRTAA
Sbjct: 1441 LPKGTKSWEEAVAAGNSGDPYPMGPFACLVQSLRSLLGEGPLERPGARLCLPDGPLRTAA 1500
Query: 1501 KRCYGKRPGLEDTAHILIAAQLWKTCDADASGTFRSCPPEALGDLPYHLLQSGNRGLLSK 1560
KRCYGKRPGLEDTAHILIAAQLWKTCDADASGTFRSCPPEALGDLPYHLLQSGNRGLLSK
Sbjct: 1501 KRCYGKRPGLEDTAHILIAAQLWKTCDADASGTFRSCPPEALGDLPYHLLQSGNRGLLSK 1560
Query: 1561 FLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVAVFRTFLRQQASILSQY 1620
FLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVAVFRTFLRQQASILSQY
Sbjct: 1561 FLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVAVFRTFLRQQASILSQY 1620
Query: 1621 PRLLPQQAANQPLDSPLCHQASLLSRRWHLQHTLRWLNKPRTMKNQQSSSLSLAVSSSPT 1680
PRLLPQQAANQPLDSPLCHQASLLSRRWHLQHTLRWLNKPRTMKNQQSSSLSLAVSSSPT
Sbjct: 1621 PRLLPQQAANQPLDSPLCHQASLLSRRWHLQHTLRWLNKPRTMKNQQSSSLSLAVSSSPT 1680
Query: 1681 AVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGL 1740
AVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGL
Sbjct: 1681 AVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGL 1740
Query: 1741 LELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYP 1800
LELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYP
Sbjct: 1741 LELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYP 1800
Query: 1801 KSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVG 1860
KSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVG
Sbjct: 1801 KSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVG 1860
Query: 1861 RLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRG 1920
RLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRG
Sbjct: 1861 RLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRG 1920
Query: 1921 HLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSP 1980
HLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSP
Sbjct: 1921 HLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSP 1980
Query: 1981 KVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQ 2040
KVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQ
Sbjct: 1981 KVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQ 2040
Query: 2041 LLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIH 2100
LLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIH
Sbjct: 2041 LLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIH 2100
Query: 2101 SFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEH 2160
SFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEH
Sbjct: 2101 SFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEH 2160
Query: 2161 VVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGAT 2220
VVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGAT
Sbjct: 2161 VVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGAT 2220
Query: 2221 RLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSS 2280
RLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSS
Sbjct: 2221 RLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSS 2280
Query: 2281 AAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHIGALIWSSAHTFFVLSADE 2340
AAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHIGALIWSSAHTFFVLSADE
Sbjct: 2281 AAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHIGALIWSSAHTFFVLSADE 2340
Query: 2341 KISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAPDGHFLILAKADLKLLCMKPG 2400
KISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAPDGHFLILAKADLKLLCMKPG
Sbjct: 2341 KISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAPDGHFLILAKADLKLLCMKPG 2400
Query: 2401 DAPSEIWSSYTENPMILSTHKEYGIFVLQPKDPGVLSFLRQKESGEFEERLNFDINLENP 2460
DAPSEIWSSYTENPMILSTHKEYGIFVLQPKDPGVLSFLRQKESGEFEERLNFDINLENP
Sbjct: 2401 DAPSEIWSSYTENPMILSTHKEYGIFVLQPKDPGVLSFLRQKESGEFEERLNFDINLENP 2460
Query: 2461 SRTLISITQAKPESESSFLCASSDGILWNLAKCSPEGEWTTGNMWQKKANTPETQTPGTD 2520
SRTLISITQAKPESESSFLCASSDGILWNLAKCSPEGEWTTGNMWQKKANTPETQTPGTD
Sbjct: 2461 SRTLISITQAKPESESSFLCASSDGILWNLAKCSPEGEWTTGNMWQKKANTPETQTPGTD 2520
Query: 2521 PSTCRESDASMDSDASMDSEPTPHLKTRQRRKIHSGSVTALHVLPELLVTASKDRDVKLW 2580
PSTCRESDASMDSDASMDSEPTPHLKTRQRRKIHSGSVTALHVLPELLVTASKDRDVKLW
Sbjct: 2521 PSTCRESDASMDSDASMDSEPTPHLKTRQRRKIHSGSVTALHVLPELLVTASKDRDVKLW 2580
Query: 2581 ERPSMQLLGLFRCEGSVSCLEPWLGANSTLQLAVGDVQGNVYFLNWE 2627
ERPSMQLLGLFRCEGSVSCLEPWLGANSTLQLAVGDVQGNVYFLNWE
Sbjct: 2581 ERPSMQLLGLFRCEGSVSCLEPWLGANSTLQLAVGDVQGNVYFLNWE 2627
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 109 bits (272), Expect = 4e-23
Identities = 150/603 (24%), Positives = 241/603 (39%), Gaps = 79/603 (13%)
Query: 1719 DGISACLFLSDDTLFLTAFDGLL-ELWDLQHGCRVLQTKA-HQYQITGCCLSPDCRLLAT 1776
+ I+A D+ + +TA LL W Q G KA H + P LLAT
Sbjct: 67 EDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLAT 126
Query: 1777 VCLGGCLKLWDTVR--GQLAFQHTYPKSLNCVAFHPEGQ--VIATGSWAGSISFFQVDGL 1832
G +++WD VR G F+ + P ++ VAFHP+ ++ + + +I + +
Sbjct: 127 GGCDGAVRVWDIVRHYGTHHFRGS-PGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDR 185
Query: 1833 KVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALF 1892
L A +++ +LAF+ G + D + +W + P AA L
Sbjct: 186 SCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLL 245
Query: 1893 ----------LHAGCQLLTAGEDGKVQVWSGSLGR----------PRGHLGSLSLSPALS 1932
G LTAG+ G ++VW + G+ P L +L+
Sbjct: 246 PEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAG 305
Query: 1933 VALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPK--VLVSGAEDG 1990
V L+ D + Y A +R+ K + G + LDV +L P+ +V +
Sbjct: 306 VVLTATADHNLLLYEARSLRLQKQFA---GYSEEVLDV-----RFLGPEDSHVVVASNSP 357
Query: 1991 SLQGWALKECSLQSLWLLSRFQKPVLGLATSQE--LLASASEDFTVQLWPRQLLTRPHKA 2048
L+ + L+ + Q +L VL L ++ L AS ++D +V++W R +KA
Sbjct: 358 CLKVFELQTSACQ---ILHGHTDIVLALDVFRKGWLFASCAKDQSVRIW------RMNKA 408
Query: 2049 EDFPCGTELRGHEGPVS--CCSFSTDGGSLATGGRDRSLLCWDVRTPKT----------- 2095
C + GH V CCS + L TG +D ++ W + PK
Sbjct: 409 GQVMCVAQGSGHTHSVGTVCCSRLKE-SFLVTGSQDCTVKLWPL--PKALLSKNTAPDNG 465
Query: 2096 PVLI--HSFPACHRDWVTGCAWT-KDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVS 2152
P+L+ + CH + A D LL + S D + LW Q LG F GH+ +
Sbjct: 466 PILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLW 525
Query: 2153 AV--AAVEEHVVSVSRDGTLKVWDHQGVE-LTSIPAHSGPISHCAAAMEPRAAGQPGSEL 2209
V + +++ + + S DGT+K+W Q L + H + A G++L
Sbjct: 526 CVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSR-------GTQL 578
Query: 2210 LVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPK 2269
L + G DG +LW TL H V S LT + D V LW+
Sbjct: 579 L--SSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVT 636
Query: 2270 EAD 2272
EA+
Sbjct: 637 EAE 639
Score = 61.2 bits (147), Expect = 1e-08
Identities = 91/428 (21%), Positives = 167/428 (39%), Gaps = 57/428 (13%)
Query: 1935 LSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPK--VLVSGAEDGSL 1992
LSPD + + RA + + GS +A+ A A P +L +G DG++
Sbjct: 74 LSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAV 133
Query: 1993 QGWALKEC--------SLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTR 2044
+ W + S + L++ P ++ LL S++ D +++W Q
Sbjct: 134 RVWDIVRHYGTHHFRGSPGVVHLVAFHPDP------TRLLLFSSATDAAIRVWSLQ---- 183
Query: 2045 PHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVR----TPKTPVL-- 2098
D C L H V+ +FS DG ++ + GRD+ + WD++ T PV
Sbjct: 184 -----DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFES 238
Query: 2099 IHSFPACHRDWVTGCAWTKDNL-LISCSSDGSVGLWDPESGQRL---------GQFLGHQ 2148
+ + + V+ L ++ G++ +W+ SGQ + GQ L H
Sbjct: 239 VEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTH- 297
Query: 2149 SAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSE 2208
+A V++ + D L +++ + + L A + ++ R G S
Sbjct: 298 ---CTLAHTAGVVLTATADHNLLLYEARSLRLQKQFA-----GYSEEVLDVRFLGPEDSH 349
Query: 2209 LLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVP 2268
++V + + L L GH+ V A V L + ++D SVR+W++
Sbjct: 350 VVVAS---NSPCLKVFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMN 406
Query: 2269 KEADDTCIPRSSAAVTAVAWA----PDGSMAVSGNQAGELILWQEAKAVATAQAPGHIGA 2324
K C+ + S +V S V+G+Q + LW KA+ + G
Sbjct: 407 KAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGP 466
Query: 2325 LIWSSAHT 2332
++ + T
Sbjct: 467 ILLQAQTT 474
Score = 56.2 bits (134), Expect = 4e-07
Identities = 125/582 (21%), Positives = 208/582 (35%), Gaps = 111/582 (19%)
Query: 1787 DTVRGQLAFQHTYPKSLNCVAFHPEG--QVIATGSWAGSISFFQVDGLKVTKDLGAPGAS 1844
+T G F+ Y F+ G Q+ TG + +V+ L+V A GA
Sbjct: 3 ETAAGVGRFKTNYAVERKIEPFYKGGKAQLDQTGQHLFCVCGTRVNILEV-----ASGAV 57
Query: 1845 IRTL---------AFNVP--GGVVAVGRLDSMVELWAWREGARLAAFPA-HHGFVAAALF 1892
+R+L AF++ V+ ++ WAW+EG+ + A H VA F
Sbjct: 58 LRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAF 117
Query: 1893 LHAGCQLLTAGEDGKVQVWS----GSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRA 1948
L T G DG V+VW RG G + L VA PD R+
Sbjct: 118 DPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHL-----VAFHPDPTRL------ 166
Query: 1949 DGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLL 2008
+L S A D +++ W+L++ S L +L
Sbjct: 167 ---------------------------------LLFSSATDAAIRVWSLQDRSC--LAVL 191
Query: 2009 SRFQKPVLGLATSQE--LLASASEDFTVQLWPRQLLTRPHKAEDFPC-GTELRGHEGPVS 2065
+ V LA S + + S+ D +W Q F + E PVS
Sbjct: 192 TAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVS 251
Query: 2066 CCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKD-NLLISC 2124
+ G T G +L W+ + + V + P +T C ++++
Sbjct: 252 QLGVKSPGLYFLTAGDQGTLRVWEAASGQC-VYTQAQPPGPGQELTHCTLAHTAGVVLTA 310
Query: 2125 SSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAV---EEHVVSVSRDGTLKVWDHQGVELT 2181
++D ++ L++ S + QF G+ V V + + HVV S LKV++ Q
Sbjct: 311 TADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQ 370
Query: 2182 SIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLL---GHS 2238
+ H+ + A++ G L + D + R+W Q + GH+
Sbjct: 371 ILHGHTDIV----LALDVFRKGW-----LFASCAKDQSVRIWRMNKAGQVMCVAQGSGHT 421
Query: 2239 GPVRAAAVSETS-GLMLTASEDGSVRLWQVPK------------------EADDTCIPRS 2279
V S ++T S+D +V+LW +PK + C +
Sbjct: 422 HSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKD 481
Query: 2280 SAAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGH 2321
+ +VA AP+ + +G+Q LW + GH
Sbjct: 482 ---INSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGH 520
Score = 49.3 bits (116), Expect = 5e-05
Identities = 92/434 (21%), Positives = 160/434 (36%), Gaps = 79/434 (18%)
Query: 2220 TRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRS 2279
TRLW + H+ PV A TS L+ T DG+VR+W + + S
Sbjct: 101 TRLWKAI----------HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGS 150
Query: 2280 SAAVTAVAWAPDGSMAVSGNQAGE--LILW----QEAKAVATAQAPGHIGALIWSSAHTF 2333
V VA+ PD + + + A + + +W + AV TA + HT
Sbjct: 151 PGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTM 210
Query: 2334 FVLSADEKISEWQVKLRKG--SAPGNLSLHLNRILQED----LGV----LTSLDWAPDGH 2383
D+ W ++ + + P S+ +L E+ LGV L L G
Sbjct: 211 LSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGT 270
Query: 2384 FLILAKADLKLLCMK-----PGDAPSEIWSSYTENPMILSTHKEYGIFVLQPKDPGVLSF 2438
+ A + + + PG + ++T ++L+ ++ + + + + S
Sbjct: 271 LRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAG-VVLTATADHNLLLYEAR-----SL 324
Query: 2439 LRQKESGEFEERLNFDINLENPSRTLISITQAKP--------ESESSFLCASSDGIL--- 2487
QK+ + E + D+ P + + + P S L +D +L
Sbjct: 325 RLQKQFAGYSEEV-LDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALD 383
Query: 2488 -----WNLAKCSPEGE---W---TTGNMWQKKANTPETQTPGT-DPSTCRESDASMDS-D 2534
W A C+ + W G + + T + GT S +ES S D
Sbjct: 384 VFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQD 443
Query: 2535 ASMDSEPTPH---------------LKTRQRRKIHSGSVTALHVLP--ELLVTASKDRDV 2577
++ P P L+ + ++ H + ++ + P +LL T S+DR
Sbjct: 444 CTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTA 503
Query: 2578 KLWERPSMQLLGLF 2591
KLW P QLLG+F
Sbjct: 504 KLWALPQCQLLGVF 517
Score = 33.1 bits (74), Expect = 3.7
Identities = 24/84 (28%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 1682 VAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTA-FDGL 1740
V FS Q A +A+GT+ L L+ + K+ + F+S T L++ DGL
Sbjct: 527 VQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGL 586
Query: 1741 LELWDLQHGCRVLQTKAHQYQITG 1764
++LW +++ V AH+ ++ G
Sbjct: 587 VKLWTIKNNECVRTLDAHEDKVWG 610
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 105 bits (262), Expect = 6e-22
Identities = 181/793 (22%), Positives = 310/793 (39%), Gaps = 108/793 (13%)
Query: 1545 LPYHLLQSGNRGLLSKFLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVA 1604
L YH+ + L + +L + A EL + L+ Y L E D A
Sbjct: 487 LAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEY-------RHILDEKDCA 539
Query: 1605 V---FRTFLRQQASILSQYP-RLLPQQAANQPLDSPLCHQASLLSRRW--HLQHTLRWLN 1658
V F+ FL +L + P + Q +P S + QA L +++ + L W+N
Sbjct: 540 VSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWIN 599
Query: 1659 KPRTMKNQQSSSLSLAVSSSPTAV---AFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVV 1715
K KN + S L V AV FS +GQR A A+ T+ + T ++ +
Sbjct: 600 K----KNITNLS-RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 654
Query: 1716 SGCDGISACLFLSDDTLFLT-AFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCR-- 1772
+ D + C F +DD T + D +++W+ G V H Q+ C +
Sbjct: 655 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 714
Query: 1773 LLATVCLGGCLKLWDTVRGQLA---FQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQV 1829
LLAT LKLWD + + F HT S+N F P+ +++A+ S G++ +
Sbjct: 715 LLATGSSDCFLKLWDLNQKECRNTMFGHT--NSVNHCRFSPDDKLLASCSADGTLKLWDA 772
Query: 1830 DGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWR-EGARLAAFPAHHGFVA 1888
K + +++ N+ ++ +V+ +W +GAR+ + F+
Sbjct: 773 TSANERKSI-----NVKQFFLNLED---PQEDMEVIVKCCSWSADGARIMVAAKNKIFL- 823
Query: 1889 AALFLHAGCQL--LTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGY 1946
+H L + G +Q S P+ HL ++LS + D
Sbjct: 824 --FDIHTSGLLGEIHTGHHSTIQYCDFS---PQNHLAVVALSQYCVELWNTDSRSKVADC 878
Query: 1947 RADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLW 2006
R ++ + G+ ++ ++D +++ W K+ S
Sbjct: 879 RGHLSWVHGVMFSPDGSS------------------FLTSSDDQTIRLWETKKVCKNSAV 920
Query: 2007 LLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSC 2066
+L K + + + + + D +L QL+ D+ E VSC
Sbjct: 921 ML----KQEVDVVFQENEVMVLAVDHIRRL---QLINGRTGQIDYLT-------EAQVSC 966
Query: 2067 CSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDN-LLISCS 2125
C S +A G + ++ ++ + I H+ V +T D LIS S
Sbjct: 967 CCLSPHLQYIAFGDENGAIEILELVNNR----IFQSRFQHKKTVWHIQFTADEKTLISSS 1022
Query: 2126 SDGSVGLWDPESGQRLGQFL-GHQSAVSAVAAVEE-HVVSVSRDGTLKVWDH-QGVELTS 2182
D + +W+ + + + FL GHQ V ++ ++S S DGT+KVW+ G +
Sbjct: 1023 DDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1080
Query: 2183 IPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVR 2242
H G + C + + + D ++W L+ H L GH+G VR
Sbjct: 1081 FVCHQGTVLSCDISHDATKFSSTSA---------DKTAKIWSFDLLLPLHELRGHNGCVR 1131
Query: 2243 AAAVSETSGLMLTASEDGSVRLWQVPK-EADDTCIPRSSAA-------VTAVAWAPDGSM 2294
+A S S L+ T ++G +R+W V E C P S VT + ++PDG M
Sbjct: 1132 CSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKM 1191
Query: 2295 AVSGNQAGELILW 2307
+S AG I W
Sbjct: 1192 LIS---AGGYIKW 1201
Score = 59.3 bits (142), Expect = 5e-08
Identities = 103/508 (20%), Positives = 177/508 (34%), Gaps = 76/508 (14%)
Query: 1692 AVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLT-AFDGLLELWDLQHGC 1750
A G+++ + L DL + ++ + ++ C F DD L + + DG L+LWD
Sbjct: 717 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSAN 776
Query: 1751 RVLQTKAHQY------------QITGCCLSPDCRLLATVCLGGCLKLWDT-VRGQLAFQH 1797
Q+ I CC V + L+D G L H
Sbjct: 777 ERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIH 836
Query: 1798 T-YPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGV 1856
T + ++ F P+ + + + D D + + + F+ G
Sbjct: 837 TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 896
Query: 1857 VAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLG 1916
D + LW ++ + +A +F +L ++Q+ +G G
Sbjct: 897 FLTSSDDQTIRLWETKKVCKNSAVMLKQE--VDVVFQENEVMVLAVDHIRRLQLINGRTG 954
Query: 1917 RPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYK-ISSGSQGAQGQALDVAVSAL 1975
+ + L+ + LSP +A G I I + +++ ++ Q
Sbjct: 955 Q----IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 1010
Query: 1976 AWLSPKVLVSGAEDGSLQ--GWALKECS--------------LQSLWLLSR--------- 2010
K L+S ++D +Q W L +C L++ LLS
Sbjct: 1011 FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVW 1070
Query: 2011 -------------FQKPVLGLATSQEL--LASASEDFTVQLWPRQLLTRPHKAEDFPCGT 2055
Q VL S + +S S D T ++W LL H
Sbjct: 1071 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLH--------- 1121
Query: 2056 ELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPK----TPVLIHSFPACHRDWVT 2111
ELRGH G V C +FS D LATG + + W+V + L A H WVT
Sbjct: 1122 ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1181
Query: 2112 GCAWTKDNLLISCSSDGSVGLWDPESGQ 2139
++ D ++ S+ G + W+ +G+
Sbjct: 1182 DLCFSPDGKML-ISAGGYIKWWNVVTGE 1208
Score = 48.9 bits (115), Expect = 7e-05
Identities = 40/158 (25%), Positives = 69/158 (43%), Gaps = 14/158 (8%)
Query: 2159 EHVVSVSRDGTLKVWDHQ-GVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLD 2217
+ + S D TL+V+ + G +L I AH + CA + + R + T +D
Sbjct: 628 QRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR---------FIATCSVD 678
Query: 2218 GATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSG--LMLTASEDGSVRLWQV-PKEADDT 2274
++W+ + HT HS V + +S L+ T S D ++LW + KE +T
Sbjct: 679 KKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNT 738
Query: 2275 CIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQEAKA 2312
++ +V ++PD + S + G L LW A
Sbjct: 739 MFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSA 775
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 105 bits (262), Expect = 6e-22
Identities = 181/793 (22%), Positives = 310/793 (39%), Gaps = 108/793 (13%)
Query: 1545 LPYHLLQSGNRGLLSKFLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVA 1604
L YH+ + L + +L + A EL + L+ Y L E D A
Sbjct: 476 LAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEY-------RHILDEKDCA 528
Query: 1605 V---FRTFLRQQASILSQYP-RLLPQQAANQPLDSPLCHQASLLSRRW--HLQHTLRWLN 1658
V F+ FL +L + P + Q +P S + QA L +++ + L W+N
Sbjct: 529 VSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWIN 588
Query: 1659 KPRTMKNQQSSSLSLAVSSSPTAV---AFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVV 1715
K KN + S L V AV FS +GQR A A+ T+ + T ++ +
Sbjct: 589 K----KNITNLS-RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643
Query: 1716 SGCDGISACLFLSDDTLFLT-AFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCR-- 1772
+ D + C F +DD T + D +++W+ G V H Q+ C +
Sbjct: 644 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 703
Query: 1773 LLATVCLGGCLKLWDTVRGQLA---FQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQV 1829
LLAT LKLWD + + F HT S+N F P+ +++A+ S G++ +
Sbjct: 704 LLATGSSDCFLKLWDLNQKECRNTMFGHT--NSVNHCRFSPDDKLLASCSADGTLKLWDA 761
Query: 1830 DGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWR-EGARLAAFPAHHGFVA 1888
K + +++ N+ ++ +V+ +W +GAR+ + F+
Sbjct: 762 TSANERKSI-----NVKQFFLNLED---PQEDMEVIVKCCSWSADGARIMVAAKNKIFL- 812
Query: 1889 AALFLHAGCQL--LTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGY 1946
+H L + G +Q S P+ HL ++LS + D
Sbjct: 813 --FDIHTSGLLGEIHTGHHSTIQYCDFS---PQNHLAVVALSQYCVELWNTDSRSKVADC 867
Query: 1947 RADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLW 2006
R ++ + G+ ++ ++D +++ W K+ S
Sbjct: 868 RGHLSWVHGVMFSPDGSS------------------FLTSSDDQTIRLWETKKVCKNSAV 909
Query: 2007 LLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSC 2066
+L K + + + + + D +L QL+ D+ E VSC
Sbjct: 910 ML----KQEVDVVFQENEVMVLAVDHIRRL---QLINGRTGQIDYLT-------EAQVSC 955
Query: 2067 CSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDN-LLISCS 2125
C S +A G + ++ ++ + I H+ V +T D LIS S
Sbjct: 956 CCLSPHLQYIAFGDENGAIEILELVNNR----IFQSRFQHKKTVWHIQFTADEKTLISSS 1011
Query: 2126 SDGSVGLWDPESGQRLGQFL-GHQSAVSAVAAVEE-HVVSVSRDGTLKVWDH-QGVELTS 2182
D + +W+ + + + FL GHQ V ++ ++S S DGT+KVW+ G +
Sbjct: 1012 DDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1069
Query: 2183 IPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVR 2242
H G + C + + + D ++W L+ H L GH+G VR
Sbjct: 1070 FVCHQGTVLSCDISHDATKFSSTSA---------DKTAKIWSFDLLLPLHELRGHNGCVR 1120
Query: 2243 AAAVSETSGLMLTASEDGSVRLWQVPK-EADDTCIPRSSAA-------VTAVAWAPDGSM 2294
+A S S L+ T ++G +R+W V E C P S VT + ++PDG M
Sbjct: 1121 CSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKM 1180
Query: 2295 AVSGNQAGELILW 2307
+S AG I W
Sbjct: 1181 LIS---AGGYIKW 1190
Score = 59.3 bits (142), Expect = 5e-08
Identities = 103/508 (20%), Positives = 177/508 (34%), Gaps = 76/508 (14%)
Query: 1692 AVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLT-AFDGLLELWDLQHGC 1750
A G+++ + L DL + ++ + ++ C F DD L + + DG L+LWD
Sbjct: 706 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSAN 765
Query: 1751 RVLQTKAHQY------------QITGCCLSPDCRLLATVCLGGCLKLWDT-VRGQLAFQH 1797
Q+ I CC V + L+D G L H
Sbjct: 766 ERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIH 825
Query: 1798 T-YPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGV 1856
T + ++ F P+ + + + D D + + + F+ G
Sbjct: 826 TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 885
Query: 1857 VAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLG 1916
D + LW ++ + +A +F +L ++Q+ +G G
Sbjct: 886 FLTSSDDQTIRLWETKKVCKNSAVMLKQE--VDVVFQENEVMVLAVDHIRRLQLINGRTG 943
Query: 1917 RPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYK-ISSGSQGAQGQALDVAVSAL 1975
+ + L+ + LSP +A G I I + +++ ++ Q
Sbjct: 944 Q----IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 999
Query: 1976 AWLSPKVLVSGAEDGSLQ--GWALKECS--------------LQSLWLLSR--------- 2010
K L+S ++D +Q W L +C L++ LLS
Sbjct: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVW 1059
Query: 2011 -------------FQKPVLGLATSQEL--LASASEDFTVQLWPRQLLTRPHKAEDFPCGT 2055
Q VL S + +S S D T ++W LL H
Sbjct: 1060 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLH--------- 1110
Query: 2056 ELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPK----TPVLIHSFPACHRDWVT 2111
ELRGH G V C +FS D LATG + + W+V + L A H WVT
Sbjct: 1111 ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1170
Query: 2112 GCAWTKDNLLISCSSDGSVGLWDPESGQ 2139
++ D ++ S+ G + W+ +G+
Sbjct: 1171 DLCFSPDGKML-ISAGGYIKWWNVVTGE 1197
Score = 48.9 bits (115), Expect = 7e-05
Identities = 40/158 (25%), Positives = 69/158 (43%), Gaps = 14/158 (8%)
Query: 2159 EHVVSVSRDGTLKVWDHQ-GVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLD 2217
+ + S D TL+V+ + G +L I AH + CA + + R + T +D
Sbjct: 617 QRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR---------FIATCSVD 667
Query: 2218 GATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSG--LMLTASEDGSVRLWQV-PKEADDT 2274
++W+ + HT HS V + +S L+ T S D ++LW + KE +T
Sbjct: 668 KKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNT 727
Query: 2275 CIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQEAKA 2312
++ +V ++PD + S + G L LW A
Sbjct: 728 MFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSA 764
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 103 bits (256), Expect = 3e-21
Identities = 74/281 (26%), Positives = 128/281 (45%), Gaps = 24/281 (8%)
Query: 2057 LRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWT 2116
L GHEG V CC F +G +LA+ G DR +L W+V ++ H V +
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDN---YATLKGHSGAVMELHYN 118
Query: 2117 KD-NLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVE---EHVVSVSRDGTLKV 2172
D ++L S S+D +V +WD E+G+R+ + GH S V++ + V + S DGT+K+
Sbjct: 119 TDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKL 178
Query: 2173 WDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTH 2232
WD + + +I A + +++ G+D ++W T+
Sbjct: 179 WDIR--KKAAIQTFQNTYQVLAVTFNDTSD-------QIISGGIDNDIKVWDLRQNKLTY 229
Query: 2233 TLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQV-PKEADDTCIPRSSAAV-------T 2284
T+ GH+ V ++S +L+ + D +VR+W V P + C+ V
Sbjct: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLL 289
Query: 2285 AVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHIGAL 2325
+W+PDGS +G+ + +W + PGH G++
Sbjct: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSI 330
Score = 63.2 bits (152), Expect = 3e-09
Identities = 77/323 (23%), Positives = 141/323 (43%), Gaps = 43/323 (13%)
Query: 1875 ARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWS-----GSLGRPRGHLGS---LS 1926
A + H G V F G L +AG D + +W+ + +GH G+ L
Sbjct: 57 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELH 116
Query: 1927 LSPALSVALSPDGDR-VAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVS 1985
+ S+ S D+ VAV G R+ ++ +G V A P+++ +
Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRL-------KGHTSFVNSCYPARRGPQLVCT 169
Query: 1986 GAEDGSLQGWAL-KECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTR 2044
G++DG+++ W + K+ ++Q+ + +Q + + + + S D +++W R
Sbjct: 170 GSDDGTVKLWDIRKKAAIQTFQ--NTYQVLAVTFNDTSDQIISGGIDNDIKVWD----LR 223
Query: 2045 PHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVR--TPKTPVL---- 2098
+K +RGH V+ S S++G L + D ++ WDVR PK +
Sbjct: 224 QNKLT-----YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQ 278
Query: 2099 --IHSFPACHRDWVTGCAWTKDNLLISC-SSDGSVGLWDPESGQRLGQFLGHQSAVSAVA 2155
+H+F + C+W+ D I+ S+D V +WD S + L + GH +++ VA
Sbjct: 279 GNVHNFEKN----LLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVA 334
Query: 2156 --AVEEHVVSVSRDGTLKVWDHQ 2176
E ++S S D L + + Q
Sbjct: 335 FHPDEPIIISASSDKRLYMGEIQ 357
Score = 61.6 bits (148), Expect = 1e-08
Identities = 71/328 (21%), Positives = 121/328 (36%), Gaps = 55/328 (16%)
Query: 1805 CVAFHPEGQVIATGSWAGSISFFQVDG-LKVTKDLGAPGASIRTLAFNVPGGVVAVGRLD 1863
C FHP G +A+ + I + V G L ++ L +N G ++ D
Sbjct: 71 CCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTD 130
Query: 1864 SMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLL-TAGEDGKVQVWSGSLGRPRGHL 1922
V +W G R+ H FV + G QL+ T +DG V++W + +
Sbjct: 131 KTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLW--DIRKKAAIQ 188
Query: 1923 GSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKV 1982
+ L+V + D++
Sbjct: 189 TFQNTYQVLAVTFNDTSDQI---------------------------------------- 208
Query: 1983 LVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQE--LLASASEDFTVQLWPRQ 2040
+SG D ++ W L++ L + + V GL+ S E L S + D TV++W +
Sbjct: 209 -ISGGIDNDIKVWDLRQNKL--TYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265
Query: 2041 LLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIH 2100
+ G + E + CS+S DG +A G DR + WD + + +++
Sbjct: 266 PFAPKERCVKIFQG-NVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRR---ILY 321
Query: 2101 SFPACHRDWVTGCAWTKDN-LLISCSSD 2127
P H + A+ D ++IS SSD
Sbjct: 322 KLPG-HAGSINEVAFHPDEPIIISASSD 348
Score = 51.2 bits (121), Expect = 1e-05
Identities = 69/275 (25%), Positives = 110/275 (40%), Gaps = 30/275 (10%)
Query: 1684 FSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDD--TLFLTAFDGLL 1741
F NG A + + L ++ + + + G G L + D LF + D +
Sbjct: 74 FHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTV 133
Query: 1742 ELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLG---GCLKLWDTVRGQLA---F 1795
+WD + G RV + K H + C P R VC G G +KLWD +R + A F
Sbjct: 134 AVWDSETGERVKRLKGHTSFVNSC--YPARRGPQLVCTGSDDGTVKLWD-IRKKAAIQTF 190
Query: 1796 QHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGG 1855
Q+TY + V F+ I +G I + + K+T + S+ L+ + G
Sbjct: 191 QNTY--QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGS 248
Query: 1856 VVAVGRLDSMVELWAWREGAR----LAAFPAH-HGFVAAAL---FLHAGCQLLTAGEDGK 1907
+ +D+ V +W R A + F + H F L + G ++ D
Sbjct: 249 YLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRF 308
Query: 1908 VQVWSGS----LGRPRGHLGSLSLSPALSVALSPD 1938
V VW + L + GH GS++ VA PD
Sbjct: 309 VYVWDTTSRRILYKLPGHAGSIN-----EVAFHPD 338
Score = 44.7 bits (104), Expect = 0.001
Identities = 33/149 (22%), Positives = 67/149 (44%), Gaps = 10/149 (6%)
Query: 1681 AVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLT-AFDG 1739
AV F+ + G + + + DLR + ++ D ++ S+ + L+ A D
Sbjct: 198 AVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDN 257
Query: 1740 LLELWDL------QHGCRVLQTKAHQYQ--ITGCCLSPDCRLLATVCLGGCLKLWDTVRG 1791
+ +WD+ + ++ Q H ++ + C SPD +A + +WDT
Sbjct: 258 TVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSR 317
Query: 1792 QLAFQHT-YPKSLNCVAFHPEGQVIATGS 1819
++ ++ + S+N VAFHP+ +I + S
Sbjct: 318 RILYKLPGHAGSINEVAFHPDEPIIISAS 346
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 99.0 bits (245), Expect = 6e-20
Identities = 96/349 (27%), Positives = 142/349 (40%), Gaps = 57/349 (16%)
Query: 2025 LASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRS 2084
LAS S D TV+ W T PH F C +GH V S+S DG LA+G ++
Sbjct: 129 LASGSGDTTVRFWDLSTET-PH----FTC----KGHRHWVLSISWSPDGRKLASGCKNGQ 179
Query: 2085 LLCWDVRTPKTPVLIHSFPACHRDWVTGCAWT------KDNLLISCSSDGSVGLWDPESG 2138
+L WD P T + A H W+TG +W + + S S DGSV +WD +G
Sbjct: 180 ILLWD---PSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAG 236
Query: 2139 QRLGQFLGHQSAVSAVAAVEEHVV-SVSRDGTLKVWD-HQGVELTSIPAHSGPISHCA-- 2194
+ GH +V+ + + ++ S S+D T+KVW H GV ++ H ++ A
Sbjct: 237 RCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALS 296
Query: 2195 -------AAMEPRAAGQPGSELL------------------------VVTVGLDGATRLW 2223
A EP A +L +V+ D LW
Sbjct: 297 TDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLW 356
Query: 2224 HPLLVCQTHT-LLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAA 2282
P + T + GH + S S ++ +AS D S++LW + AA
Sbjct: 357 SPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAA 416
Query: 2283 VTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGH---IGALIWS 2328
V +AW+ D + VSG+ L +W PGH + A+ WS
Sbjct: 417 VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWS 465
Score = 90.5 bits (223), Expect = 2e-17
Identities = 93/388 (23%), Positives = 155/388 (39%), Gaps = 83/388 (21%)
Query: 2053 CGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTG 2112
C + L GH V +FS G LA+G D ++ WD+ T +TP H HR WV
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLST-ETP---HFTCKGHRHWVLS 161
Query: 2113 CAWTKD-NLLISCSSDGSVGLWDPESGQRLGQFL-GHQSAVSAVAAVEEH-------VVS 2163
+W+ D L S +G + LWDP +G+++G+ L GH ++ ++ H V S
Sbjct: 162 ISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVAS 221
Query: 2164 VSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLW 2223
S+DG++++WD I C + G + L+ + D ++W
Sbjct: 222 SSKDGSVRIWDTTAGRCERILTGHTQSVTCL---------RWGGDGLLYSASQDRTIKVW 272
Query: 2224 --HPLLVCQTHTLLGHSGPVRAAAVSETSGL----------------------------- 2252
H ++C+ TL GH V A+S L
Sbjct: 273 RAHDGVLCR--TLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERAL 330
Query: 2253 -------------MLTASEDGSVRLWQVPKEADD-TCIPRSSAAVTAVAWAPDGSMAVSG 2298
+++ S+D ++ LW ++ T + A + V ++PD + S
Sbjct: 331 SRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASA 390
Query: 2299 NQAGELILWQEAKAVATAQAPGHIGA---LIWSSAHTFFVL-SADEKISEWQVKLRKGSA 2354
+ + LW A GH+ A + WS+ V S+D + W VK +K
Sbjct: 391 SFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQK--- 447
Query: 2355 PGNLSLHLNRILQEDLGVLTSLDWAPDG 2382
L++ L E + ++DW+PDG
Sbjct: 448 ---LAMDLPGHADE----VYAVDWSPDG 468
Score = 87.8 bits (216), Expect = 1e-16
Identities = 105/387 (27%), Positives = 169/387 (43%), Gaps = 42/387 (10%)
Query: 1806 VAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSM 1865
VAF P G+ +A+GS ++ F+ + + +++++ G +A G +
Sbjct: 120 VAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQ 179
Query: 1866 VELWAWREGARLAAFPAHHGFVAAALF---LHAGCQ---LLTAGEDGKVQVWSGSLGRPR 1919
+ LW G ++ A H L LHA + + ++ +DG V++W + GR
Sbjct: 180 ILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCE 239
Query: 1920 ----GHLGSLSLS--PALSVALSPDGDRVAVGYRA-DGIRIYKISSGSQGAQGQAL--DV 1970
GH S++ + S DR +RA DG+ + AL D
Sbjct: 240 RILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 299
Query: 1971 AVSALAWLSPKVLVSGAE-DGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASAS 2029
A+ A+ + V+ + GSLQ LKE +L S + L R Q P E L S S
Sbjct: 300 ALRTGAFEPAEASVNPQDLQGSLQ--ELKERAL-SRYNLVRGQGP--------ERLVSGS 348
Query: 2030 EDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWD 2089
+DFT+ LW AED T + GH+ ++ FS D +A+ D+S+ WD
Sbjct: 349 DDFTLFLW--------SPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 400
Query: 2090 VRTPKTPVLIHSFPACHRDWVTGCAWTKDN-LLISCSSDGSVGLWDPESGQRLGQFLGHQ 2148
RT K + A V AW+ D+ LL+S SSD ++ +WD ++ + GH
Sbjct: 401 GRTGKYLASLRGHVAA----VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHA 456
Query: 2149 SAVSAV--AAVEEHVVSVSRDGTLKVW 2173
V AV + + V S +D L++W
Sbjct: 457 DEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 81.6 bits (200), Expect = 9e-15
Identities = 97/393 (24%), Positives = 163/393 (41%), Gaps = 41/393 (10%)
Query: 1931 LSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSP--KVLVSGAE 1988
+SVA SP G +A G +R + +S+ + + V +++W SP + L SG +
Sbjct: 118 ISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW-SPDGRKLASGCK 176
Query: 1989 DGSLQGW-------ALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQL 2041
+G + W + + S W+ +P L +AS+S+D +V++W
Sbjct: 177 NGQILLWDPSTGKQVGRTLAGHSKWITGLSWEP-LHANPECRYVASSSKDGSVRIWDTTA 235
Query: 2042 LTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHS 2101
C L GH V+C + DG L + +DR++ W VL +
Sbjct: 236 GR---------CERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDG---VLCRT 282
Query: 2102 FPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVE--- 2158
H WV A + D L + + + + +P+ Q Q L + A+S V
Sbjct: 283 LQG-HGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQEL-KERALSRYNLVRGQG 340
Query: 2159 -EHVVSVSRDGTLKVWD--HQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVG 2215
E +VS S D TL +W LT + H I+ + + R +V +
Sbjct: 341 PERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSR---------IVASAS 391
Query: 2216 LDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTC 2275
D + +LW +L GH V A S S L+++ S D ++++W V +
Sbjct: 392 FDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD 451
Query: 2276 IPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQ 2308
+P + V AV W+PDG SG + L +W+
Sbjct: 452 LPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Score = 66.6 bits (161), Expect = 3e-10
Identities = 98/412 (23%), Positives = 158/412 (38%), Gaps = 79/412 (19%)
Query: 1738 DGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ----- 1792
D + WDL K H++ + SPD R LA+ C G + LWD G+
Sbjct: 135 DTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRT 194
Query: 1793 LAFQHTYPKSLNCVAFH--PEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAF 1850
LA + L+ H PE + +A+ S GS+ + + + L S+ L +
Sbjct: 195 LAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRW 254
Query: 1851 NVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQV 1910
G + + + D +++W AH G + L H
Sbjct: 255 GGDGLLYSASQ-DRTIKVWR-----------AHDGVLCRTLQGH---------------- 286
Query: 1911 WSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDV 1970
GH + ++ALS D R + S Q QG ++
Sbjct: 287 ---------GHWVN-------TMALSTD-----YALRTGAFEPAEASVNPQDLQGSLQEL 325
Query: 1971 AVSALAWLS------PKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQE- 2023
AL+ + P+ LVSG++D +L W+ E + L ++ Q + + S +
Sbjct: 326 KERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAE-DKKPLTRMTGHQALINQVLFSPDS 384
Query: 2024 -LLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRD 2082
++ASAS D +++LW + T + A LRGH V ++S D L +G D
Sbjct: 385 RIVASASFDKSIKLWDGR--TGKYLA-------SLRGHVAAVYQIAWSADSRLLVSGSSD 435
Query: 2083 RSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLI-SCSSDGSVGLW 2133
+L WDV+ K L P H D V W+ D + S D + +W
Sbjct: 436 STLKVWDVKAQK---LAMDLPG-HADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 42.4 bits (98), Expect = 0.006
Identities = 37/138 (26%), Positives = 63/138 (45%), Gaps = 13/138 (9%)
Query: 1689 QRAAVGTANGTVYLLDLRTWQ--EEKSVVSGCDG----ISACLFLSDDTLFLTA-FDGLL 1741
+R G+ + T++L W E+K ++ G I+ LF D + +A FD +
Sbjct: 342 ERLVSGSDDFTLFL-----WSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSI 396
Query: 1742 ELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQ-HTYP 1800
+LWD + G + + H + S D RLL + LK+WD +LA +
Sbjct: 397 KLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHA 456
Query: 1801 KSLNCVAFHPEGQVIATG 1818
+ V + P+GQ +A+G
Sbjct: 457 DEVYAVDWSPDGQRVASG 474
Score = 41.6 bits (96), Expect = 0.010
Identities = 56/269 (20%), Positives = 101/269 (37%), Gaps = 9/269 (3%)
Query: 1692 AVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLLELWDLQHG-- 1749
A + +G+V + D + E+ + ++ + D L+ + D +++W G
Sbjct: 220 ASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVL 279
Query: 1750 CRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSL---NCV 1806
CR LQ H + + LS D L T + Q + Q ++L N V
Sbjct: 280 CRTLQ--GHGHWVNTMALSTDYAL-RTGAFEPAEASVNPQDLQGSLQELKERALSRYNLV 336
Query: 1807 AFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMV 1866
++++ + + K + A I + F+ +VA D +
Sbjct: 337 RGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSI 396
Query: 1867 ELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLS 1926
+LW R G LA+ H V + L++ D ++VW + L
Sbjct: 397 KLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPG-H 455
Query: 1927 LSPALSVALSPDGDRVAVGYRADGIRIYK 1955
+V SPDG RVA G + +RI++
Sbjct: 456 ADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Score = 32.3 bits (72), Expect = 6.3
Identities = 39/153 (25%), Positives = 64/153 (41%), Gaps = 27/153 (17%)
Query: 2444 SGEFEERLNF-DINLENPSRT-------LISITQAKPESESSFLCASSDGILWNLAKCSP 2495
SG + + F D++ E P T ++SI+ + + + C + +LW+ +
Sbjct: 131 SGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQ 190
Query: 2496 EG-------EWTTGNMWQKKANTPETQTPGTDPSTCRESDASMDSDASMDSEPTPHLKTR 2548
G +W TG W+ PE CR AS D S+ T +
Sbjct: 191 VGRTLAGHSKWITGLSWEPLHANPE----------CRYV-ASSSKDGSVRIWDTTAGRCE 239
Query: 2549 QRRKIHSGSVTALHVLPE-LLVTASKDRDVKLW 2580
+ H+ SVT L + LL +AS+DR +K+W
Sbjct: 240 RILTGHTQSVTCLRWGGDGLLYSASQDRTIKVW 272
Score = 32.0 bits (71), Expect = 8.3
Identities = 23/106 (21%), Positives = 49/106 (46%), Gaps = 1/106 (0%)
Query: 1682 VAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLT-AFDGL 1740
V FS + + A + + ++ L D RT + S+ + + +D L ++ + D
Sbjct: 378 VLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDST 437
Query: 1741 LELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLW 1786
L++WD++ + H ++ SPD + +A+ CL++W
Sbjct: 438 LKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 88.2 bits (217), Expect = 1e-16
Identities = 158/689 (22%), Positives = 271/689 (39%), Gaps = 81/689 (11%)
Query: 1545 LPYHLLQSGNRGLLSKFLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVA 1604
L YH+ + L + +L + A EL + L+ Y L E D A
Sbjct: 487 LAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEY-------RHILDEKDCA 539
Query: 1605 V---FRTFLRQQASILSQYP-RLLPQQAANQPLDSPLCHQASLLSRRW--HLQHTLRWLN 1658
V F+ FL +L + P + Q +P S + QA L +++ + L W+N
Sbjct: 540 VSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWIN 599
Query: 1659 KPRTMKNQQSSSLSLAVSSSPTAV---AFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVV 1715
K KN + S L V AV FS +GQR A A+ T+ + T ++ +
Sbjct: 600 K----KNITNLS-RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 654
Query: 1716 SGCDGISACLFLSDDTLFLT-AFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCR-- 1772
+ D + C F +DD T + D +++W+ G V H Q+ C +
Sbjct: 655 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 714
Query: 1773 LLATVCLGGCLKLWDTVRGQLA---FQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQV 1829
LLAT LKLWD + + F HT S+N F P+ +++A+ S G++ +
Sbjct: 715 LLATGSSDCFLKLWDLNQKECRNTMFGHT--NSVNHCRFSPDDKLLASCSADGTLKLWDA 772
Query: 1830 DGLKVTKDLGAPG-------------ASIRTLAFNVPGGVVAVGRLDSMVELWAWREGAR 1876
K + ++ +++ G + V + + LW ++
Sbjct: 773 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSK 831
Query: 1877 LAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALS 1936
+A H +V +F G LT+ +D +++W ++ L + V
Sbjct: 832 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNS---AVMLKQEVDVVFQ 888
Query: 1937 PDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKV--LVSGAEDGSLQG 1994
+ V D IR ++ +G G + VS LSP + + G E+G+++
Sbjct: 889 ENEVMVLA---VDHIRRLQLINGRTGQIDYLTEAQVSCCC-LSPHLQYIAFGDENGAIEI 944
Query: 1995 WALKECSLQSLWLLSRFQ--KPV--LGLATSQELLASASEDFTVQLWPRQLLTRPHKAED 2050
L + + SRFQ K V + ++ L S+S+D +Q+W QL
Sbjct: 945 LEL----VNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL--------- 991
Query: 2051 FPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWV 2110
C LRGH+ V L + D ++ W++ T CH+ V
Sbjct: 992 DKC-IFLRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNK----EKDFVCHQGTV 1045
Query: 2111 TGCAWTKD-NLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVA-AVEEHVVSVSRD- 2167
C + D S S+D + +W + L + GH V A +V+ +++ D
Sbjct: 1046 LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDN 1105
Query: 2168 GTLKVWDHQGVELTSIPAHSGPISHCAAA 2196
G +++W+ EL + A P+S AA
Sbjct: 1106 GEIRIWNVSNGELLHLCA---PLSEEGAA 1131
Score = 79.7 bits (195), Expect = 3e-14
Identities = 121/566 (21%), Positives = 214/566 (37%), Gaps = 96/566 (16%)
Query: 1808 FHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVE 1867
F +GQ IA+ ++ F+ + + ++ A + AF+ +A +D V+
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 1868 LWAWREGARLAAFPAHHGFVAAALFLHAGCQLL--TAGEDGKVQVWSGSLGRPR----GH 1921
+W G + + H V F ++ LL T D +++W + R GH
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 1922 LGSLSLSPALSVALSPDGDRVAVGYRADG-IRIYKISSGSQGAQ-------------GQA 1967
S++ SPD D++ ADG ++++ +S ++ +
Sbjct: 743 TNSVN-----HCRFSPD-DKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQED 796
Query: 1968 LDVAVSALAWLSPKVLVSGAEDGSLQGW------ALKECSLQSLWLLSRFQKPVLGLATS 2021
++V V +W + + A + W + +C W+ P
Sbjct: 797 MEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSP------D 850
Query: 2022 QELLASASEDFTVQLWPRQLLTRPHK-------------------AEDFPCGTELRGH-- 2060
++S+D T++LW + + + A D +L
Sbjct: 851 GSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRT 910
Query: 2061 -------EGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGC 2113
E VSCC S +A G + ++ ++ + I H+ V
Sbjct: 911 GQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR----IFQSRFQHKKTVWHI 966
Query: 2114 AWTKDN-LLISCSSDGSVGLWDPESGQRLGQFL-GHQSAVSAVAAVEE-HVVSVSRDGTL 2170
+T D LIS S D + +W+ + + + FL GHQ V ++ ++S S DGT+
Sbjct: 967 QFTADEKTLISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSRLLSWSFDGTV 1024
Query: 2171 KVWDH-QGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVC 2229
KVW+ G + H G + C + + + D ++W L+
Sbjct: 1025 KVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSA---------DKTAKIWSFDLLL 1075
Query: 2230 QTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPK-EADDTCIPRSSAA------ 2282
H L GH+G VR +A S S L+ T ++G +R+W V E C P S
Sbjct: 1076 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGG 1135
Query: 2283 -VTAVAWAPDGSMAVSGNQAGELILW 2307
VT + ++PDG M +S AG I W
Sbjct: 1136 WVTDLCFSPDGKMLIS---AGGYIKW 1158
Score = 66.2 bits (160), Expect = 4e-10
Identities = 67/323 (20%), Positives = 127/323 (39%), Gaps = 37/323 (11%)
Query: 2106 HRDWVTGCAWTKDNLLI-SCSSDGSVGLWDPESGQRLGQFLGHQSAV--SAVAAVEEHVV 2162
H D V +++D I SC +D ++ ++ E+G++L + H+ V A + + +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 2163 SVSRDGTLKVWDHQGVELT-SIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATR 2221
+ S D +K+W+ EL + HS ++ C LL+ T D +
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT-------NSSHHLLLATGSSDCFLK 726
Query: 2222 LWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCI----- 2276
LW +T+ GH+ V S L+ + S DG+++LW + I
Sbjct: 727 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQF 786
Query: 2277 ------PRS--SAAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHI----GA 2324
P+ V +W+ DG+ + + ++ LW A GH+ G
Sbjct: 787 FLNLEDPQEDMEVIVKCCSWSADGARIMVAAK-NKIFLWNTDSRSKVADCRGHLSWVHGV 845
Query: 2325 LIWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDW------ 2378
+ +F S D+ I W+ K ++ L ++ + QE+ ++ ++D
Sbjct: 846 MFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQL 905
Query: 2379 --APDGHFLILAKADLKLLCMKP 2399
G L +A + C+ P
Sbjct: 906 INGRTGQIDYLTEAQVSCCCLSP 928
Score = 35.0 bits (79), Expect = 0.98
Identities = 31/131 (23%), Positives = 51/131 (38%), Gaps = 10/131 (7%)
Query: 1697 NGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFL-TAFDGLLELWDLQHGCRVLQT 1755
+GTV + ++ T +EK V + +C D T F T+ D ++W + +
Sbjct: 1021 DGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHEL 1080
Query: 1756 KAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQVI 1815
+ H + S D LLAT G +++W+ G+L C EG
Sbjct: 1081 RGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL--------CAPLSEEG-AA 1131
Query: 1816 ATGSWAGSISF 1826
G W + F
Sbjct: 1132 THGGWVTDLCF 1142
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 88.2 bits (217), Expect = 1e-16
Identities = 158/689 (22%), Positives = 271/689 (39%), Gaps = 81/689 (11%)
Query: 1545 LPYHLLQSGNRGLLSKFLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVA 1604
L YH+ + L + +L + A EL + L+ Y L E D A
Sbjct: 476 LAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEY-------RHILDEKDCA 528
Query: 1605 V---FRTFLRQQASILSQYP-RLLPQQAANQPLDSPLCHQASLLSRRW--HLQHTLRWLN 1658
V F+ FL +L + P + Q +P S + QA L +++ + L W+N
Sbjct: 529 VSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWIN 588
Query: 1659 KPRTMKNQQSSSLSLAVSSSPTAV---AFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVV 1715
K KN + S L V AV FS +GQR A A+ T+ + T ++ +
Sbjct: 589 K----KNITNLS-RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643
Query: 1716 SGCDGISACLFLSDDTLFLT-AFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCR-- 1772
+ D + C F +DD T + D +++W+ G V H Q+ C +
Sbjct: 644 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 703
Query: 1773 LLATVCLGGCLKLWDTVRGQLA---FQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQV 1829
LLAT LKLWD + + F HT S+N F P+ +++A+ S G++ +
Sbjct: 704 LLATGSSDCFLKLWDLNQKECRNTMFGHT--NSVNHCRFSPDDKLLASCSADGTLKLWDA 761
Query: 1830 DGLKVTKDLGAPG-------------ASIRTLAFNVPGGVVAVGRLDSMVELWAWREGAR 1876
K + ++ +++ G + V + + LW ++
Sbjct: 762 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSK 820
Query: 1877 LAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALS 1936
+A H +V +F G LT+ +D +++W ++ L + V
Sbjct: 821 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNS---AVMLKQEVDVVFQ 877
Query: 1937 PDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKV--LVSGAEDGSLQG 1994
+ V D IR ++ +G G + VS LSP + + G E+G+++
Sbjct: 878 ENEVMVLA---VDHIRRLQLINGRTGQIDYLTEAQVSCCC-LSPHLQYIAFGDENGAIEI 933
Query: 1995 WALKECSLQSLWLLSRFQ--KPV--LGLATSQELLASASEDFTVQLWPRQLLTRPHKAED 2050
L + + SRFQ K V + ++ L S+S+D +Q+W QL
Sbjct: 934 LEL----VNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL--------- 980
Query: 2051 FPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWV 2110
C LRGH+ V L + D ++ W++ T CH+ V
Sbjct: 981 DKC-IFLRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNK----EKDFVCHQGTV 1034
Query: 2111 TGCAWTKD-NLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVA-AVEEHVVSVSRD- 2167
C + D S S+D + +W + L + GH V A +V+ +++ D
Sbjct: 1035 LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDN 1094
Query: 2168 GTLKVWDHQGVELTSIPAHSGPISHCAAA 2196
G +++W+ EL + A P+S AA
Sbjct: 1095 GEIRIWNVSNGELLHLCA---PLSEEGAA 1120
Score = 79.7 bits (195), Expect = 3e-14
Identities = 121/566 (21%), Positives = 214/566 (37%), Gaps = 96/566 (16%)
Query: 1808 FHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVE 1867
F +GQ IA+ ++ F+ + + ++ A + AF+ +A +D V+
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
Query: 1868 LWAWREGARLAAFPAHHGFVAAALFLHAGCQLL--TAGEDGKVQVWSGSLGRPR----GH 1921
+W G + + H V F ++ LL T D +++W + R GH
Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
Query: 1922 LGSLSLSPALSVALSPDGDRVAVGYRADG-IRIYKISSGSQGAQ-------------GQA 1967
S++ SPD D++ ADG ++++ +S ++ +
Sbjct: 732 TNSVN-----HCRFSPD-DKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQED 785
Query: 1968 LDVAVSALAWLSPKVLVSGAEDGSLQGW------ALKECSLQSLWLLSRFQKPVLGLATS 2021
++V V +W + + A + W + +C W+ P
Sbjct: 786 MEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSP------D 839
Query: 2022 QELLASASEDFTVQLWPRQLLTRPHK-------------------AEDFPCGTELRGH-- 2060
++S+D T++LW + + + A D +L
Sbjct: 840 GSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRT 899
Query: 2061 -------EGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGC 2113
E VSCC S +A G + ++ ++ + I H+ V
Sbjct: 900 GQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR----IFQSRFQHKKTVWHI 955
Query: 2114 AWTKDN-LLISCSSDGSVGLWDPESGQRLGQFL-GHQSAVSAVAAVEE-HVVSVSRDGTL 2170
+T D LIS S D + +W+ + + + FL GHQ V ++ ++S S DGT+
Sbjct: 956 QFTADEKTLISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSRLLSWSFDGTV 1013
Query: 2171 KVWDH-QGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVC 2229
KVW+ G + H G + C + + + D ++W L+
Sbjct: 1014 KVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSA---------DKTAKIWSFDLLL 1064
Query: 2230 QTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPK-EADDTCIPRSSAA------ 2282
H L GH+G VR +A S S L+ T ++G +R+W V E C P S
Sbjct: 1065 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGG 1124
Query: 2283 -VTAVAWAPDGSMAVSGNQAGELILW 2307
VT + ++PDG M +S AG I W
Sbjct: 1125 WVTDLCFSPDGKMLIS---AGGYIKW 1147
Score = 66.2 bits (160), Expect = 4e-10
Identities = 67/323 (20%), Positives = 127/323 (39%), Gaps = 37/323 (11%)
Query: 2106 HRDWVTGCAWTKDNLLI-SCSSDGSVGLWDPESGQRLGQFLGHQSAV--SAVAAVEEHVV 2162
H D V +++D I SC +D ++ ++ E+G++L + H+ V A + + +
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
Query: 2163 SVSRDGTLKVWDHQGVELT-SIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATR 2221
+ S D +K+W+ EL + HS ++ C LL+ T D +
Sbjct: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT-------NSSHHLLLATGSSDCFLK 715
Query: 2222 LWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCI----- 2276
LW +T+ GH+ V S L+ + S DG+++LW + I
Sbjct: 716 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQF 775
Query: 2277 ------PRS--SAAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHI----GA 2324
P+ V +W+ DG+ + + ++ LW A GH+ G
Sbjct: 776 FLNLEDPQEDMEVIVKCCSWSADGARIMVAAK-NKIFLWNTDSRSKVADCRGHLSWVHGV 834
Query: 2325 LIWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDW------ 2378
+ +F S D+ I W+ K ++ L ++ + QE+ ++ ++D
Sbjct: 835 MFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQL 894
Query: 2379 --APDGHFLILAKADLKLLCMKP 2399
G L +A + C+ P
Sbjct: 895 INGRTGQIDYLTEAQVSCCCLSP 917
Score = 35.0 bits (79), Expect = 0.98
Identities = 31/131 (23%), Positives = 51/131 (38%), Gaps = 10/131 (7%)
Query: 1697 NGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFL-TAFDGLLELWDLQHGCRVLQT 1755
+GTV + ++ T +EK V + +C D T F T+ D ++W + +
Sbjct: 1010 DGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHEL 1069
Query: 1756 KAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQVI 1815
+ H + S D LLAT G +++W+ G+L C EG
Sbjct: 1070 RGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL--------CAPLSEEG-AA 1120
Query: 1816 ATGSWAGSISF 1826
G W + F
Sbjct: 1121 THGGWVTDLCF 1131
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 88.2 bits (217), Expect = 1e-16
Identities = 73/250 (29%), Positives = 111/250 (44%), Gaps = 32/250 (12%)
Query: 2024 LLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDR 2083
LLASAS D TV+LW P K F +E + H PV FS DG LAT D+
Sbjct: 74 LLASASRDRTVRLWI------PDKRGKF---SEFKAHTAPVRSVDFSADGQFLATASEDK 124
Query: 2084 SLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKD-NLLISCSSDGSVGLWDPESGQRLG 2142
S+ W + + ++ H WV ++ D L++SCS D ++ +WD + Q +
Sbjct: 125 SIKVWSMYRQRFLYSLYR----HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180
Query: 2143 QFLGHQSAVSAVAAVEEH-----VVSVSRDGTLKVWDHQGVELTS-IPAHSGPISHCAAA 2196
F +V V+ + + S D T+KVWD + +L HSG ++ +
Sbjct: 181 NF---SDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVN--CIS 235
Query: 2197 MEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTA 2256
P S ++T DG ++ L +TL GH+GPV + S+ L +
Sbjct: 236 FHP-------SGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASG 288
Query: 2257 SEDGSVRLWQ 2266
D V LW+
Sbjct: 289 GADTQVLLWR 298
Score = 68.6 bits (166), Expect = 8e-11
Identities = 68/286 (23%), Positives = 125/286 (43%), Gaps = 7/286 (2%)
Query: 1756 KAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKS-LNCVAFHPEGQV 1814
K H+ IT LSP+ + LAT L LW+ A+++ K + V F P G +
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL 74
Query: 1815 IATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREG 1874
+A+ S ++ + D + A A +R++ F+ G +A D +++W+
Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQ 134
Query: 1875 ARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVA 1934
L + H +V A F G +++ ED +++W + + + S S+ A V
Sbjct: 135 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD-TTNKQCVNNFSDSVGFANFVD 193
Query: 1935 LSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAW-LSPKVLVSGAEDGSLQ 1993
+P G +A ++++ + Q V+ +++ S L++ + DG+L+
Sbjct: 194 FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLK 253
Query: 1994 GWALKECSLQSLWLLSRFQKPVLGLATSQ--ELLASASEDFTVQLW 2037
L E L ++ L PV ++ S+ EL AS D V LW
Sbjct: 254 ILDLLEGRL--IYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 68.6 bits (166), Expect = 8e-11
Identities = 62/272 (22%), Positives = 109/272 (40%), Gaps = 11/272 (4%)
Query: 1680 TAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAF-D 1738
T++ S NG++ A + + + L + + V D +++ F L +A D
Sbjct: 22 TSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRD 81
Query: 1739 GLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQ-H 1797
+ LW + + KAH + S D + LAT +K+W R + + +
Sbjct: 82 RTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLY 141
Query: 1798 TYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVV 1857
+ + C F P+G++I + S +I + + + + FN G +
Sbjct: 142 RHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCI 201
Query: 1858 AVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGR 1917
A D V++W R L + H G V F +G L+TA DG +++ GR
Sbjct: 202 ASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGR 261
Query: 1918 ----PRGHLGSLSLSPALSVALSPDGDRVAVG 1945
+GH G P +V+ S G+ A G
Sbjct: 262 LIYTLQGHTG-----PVFTVSFSKGGELFASG 288
Score = 64.3 bits (155), Expect = 2e-09
Identities = 70/318 (22%), Positives = 128/318 (40%), Gaps = 25/318 (7%)
Query: 2058 RGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTK 2117
+GH+ ++ S +G LAT D L+ W+ + P + H+D VT ++
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFK-PHARAYRY---VGHKDVVTSVQFSP 70
Query: 2118 D-NLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAV--AAVEEHVVSVSRDGTLKVWD 2174
NLL S S D +V LW P+ + +F H + V +V +A + + + S D ++KVW
Sbjct: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130
Query: 2175 -HQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHT 2233
++ L S+ H+ + R A L+V+ D ++W +
Sbjct: 131 MYRQRFLYSLYRHTHWV---------RCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
Query: 2234 LLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGS 2293
G + + + +A D +V++W V S V +++ P G+
Sbjct: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241
Query: 2294 MAVSGNQAGELILWQ--EAKAVATAQAPGHIGALIWSS----AHTFFVLSADEKISEWQV 2347
++ + G L + E + + T Q GH G + S F AD ++ W+
Sbjct: 242 YLITASSDGTLKILDLLEGRLIYTLQ--GHTGPVFTVSFSKGGELFASGGADTQVLLWRT 299
Query: 2348 KLRKGSAPGNLSLHLNRI 2365
+ G +L R+
Sbjct: 300 NFDELHCKGLTKRNLKRL 317
Score = 56.6 bits (135), Expect = 3e-07
Identities = 45/197 (22%), Positives = 82/197 (41%), Gaps = 16/197 (8%)
Query: 2210 LVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPK 2269
L+ + D RLW P + H+ PVR+ S + TASED S+++W + +
Sbjct: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
Query: 2270 EADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHIGALIW-- 2327
+ + R + V ++PDG + VS ++ + +W +G +
Sbjct: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD 193
Query: 2328 --SSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAPDGHFL 2385
S +D+ + W V++ K L + Q G + + + P G++L
Sbjct: 194 FNPSGTCIASAGSDQTVKVWDVRVNK----------LLQHYQVHSGGVNCISFHPSGNYL 243
Query: 2386 ILAKAD--LKLLCMKPG 2400
I A +D LK+L + G
Sbjct: 244 ITASSDGTLKILDLLEG 260
Score = 54.3 bits (129), Expect = 2e-06
Identities = 52/241 (21%), Positives = 94/241 (39%), Gaps = 16/241 (6%)
Query: 1680 TAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEK-----SVVSGCDGISACLFLSDDTLFL 1734
T+V FS +G A + + TV R W +K + + + F +D
Sbjct: 64 TSVQFSPHGNLLASASRDRTV-----RLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLA 118
Query: 1735 TAF-DGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQL 1793
TA D +++W + + H + + SPD RL+ + +K+WDT Q
Sbjct: 119 TASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC 178
Query: 1794 AFQHTYPKSL---NCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAF 1850
+ + S+ N V F+P G IA+ ++ + V K+ + + ++F
Sbjct: 179 V--NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISF 236
Query: 1851 NVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQV 1910
+ G + D +++ EG + H G V F G + G D +V +
Sbjct: 237 HPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLL 296
Query: 1911 W 1911
W
Sbjct: 297 W 297
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 87.0 bits (214), Expect = 2e-16
Identities = 60/220 (27%), Positives = 88/220 (40%), Gaps = 23/220 (10%)
Query: 2060 HEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDN 2119
H G ++ S S DG L TG D + W + L+ H +VT C +D
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQG----HESYVTFCQ-LEDE 68
Query: 2120 LLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWD----- 2174
+CS+D ++ WD +GQ L + GH S V+ + + S S D T +VW
Sbjct: 69 AAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQ 128
Query: 2175 -------HQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLL 2227
H+ LT + + A E A G L+VT DG ++W
Sbjct: 129 MSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGG------LLVTGSTDGTAKVWQVAS 182
Query: 2228 VCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQV 2267
C TL GH+G V + T S D ++R W +
Sbjct: 183 GCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
Score = 68.2 bits (165), Expect = 1e-10
Identities = 90/389 (23%), Positives = 141/389 (36%), Gaps = 76/389 (19%)
Query: 1845 IRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQL----- 1899
I L+ + G + G D LW+ +G A H +V CQL
Sbjct: 18 INWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTF-------CQLEDEAA 70
Query: 1900 LTAGEDGKVQVWSGSLGRP----RGHLGSLS-LSPALSVALSPDGDRVAVGYRADGIRIY 1954
T D ++ W G+ RGH ++ + A + S DR A R++
Sbjct: 71 FTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTA--------RVW 122
Query: 1955 KISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKP 2014
+ G + + V LA+ +P W L P
Sbjct: 123 SVDKGQMSREFRGHRNCVLTLAYSAP--------------WDLPST-------------P 155
Query: 2015 VLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGG 2074
A + LL + S D T ++W + C LRGH G V C T G
Sbjct: 156 CAEEAAAGGLLVTGSTDGTAKVW---------QVASGCCHQTLRGHTGAVLCLVLDTPGH 206
Query: 2075 SLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWD 2134
+ TG D ++ WD+ + + + HR V C + L+ S S+D +V W
Sbjct: 207 TAFTGSTDATIRAWDILSGEQLRVFRE----HRGSVI-CLELVNRLVYSGSADRTVKCWL 261
Query: 2135 PESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCA 2194
++G+ + F H+ VSA+ + + S D + +D Q EL + I +C
Sbjct: 262 ADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCI 321
Query: 2195 AAMEPRAAGQPGSELLVVTVGLDGATRLW 2223
+ GQ ++ T DGA RLW
Sbjct: 322 -----QVHGQ-----VLYTASHDGALRLW 340
Score = 47.8 bits (112), Expect = 1e-04
Identities = 70/338 (20%), Positives = 125/338 (36%), Gaps = 36/338 (10%)
Query: 1682 VAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLL 1741
++ S +GQR G+ +GT L Q +++ G + L D+ F + D +
Sbjct: 21 LSLSPDGQRLLTGSEDGTARLWSTADGQC-CALLQGHESYVTFCQLEDEAAFTCSADCTI 79
Query: 1742 ELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ--------- 1792
WD+ G + LQ I L + +L ++ ++W +GQ
Sbjct: 80 RRWDVLTG-QCLQVYRGHTSIVNRILVANNQLFSS-SYDRTARVWSVDKGQMSREFRGHR 137
Query: 1793 ---LAFQHTYP---KSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIR 1846
L ++ P S C G ++ TGS G+ +QV + L ++
Sbjct: 138 NCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVL 197
Query: 1847 TLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGE-D 1905
L + PG G D+ + W G +L F H G V + L +L+ +G D
Sbjct: 198 CLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV---ICLELVNRLVYSGSAD 254
Query: 1906 GKVQVWSGSLGRP----RGHLGSLS-LSPALSVALSPDGDRVAVGYRADGIRIYKISSGS 1960
V+ W G H ++S L + GD A + A + ++ G
Sbjct: 255 RTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRG- 313
Query: 1961 QGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALK 1998
+ + +VL + + DG+L+ W ++
Sbjct: 314 --------HTFIINCIQVHGQVLYTASHDGALRLWDVR 343
Score = 40.8 bits (94), Expect = 0.018
Identities = 46/180 (25%), Positives = 75/180 (41%), Gaps = 10/180 (5%)
Query: 1682 VAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLL 1741
+ T G A G+ + T+ D+ + E+ V G CL L + ++ + D +
Sbjct: 199 LVLDTPGHTAFTGSTDATIRAWDILSG-EQLRVFREHRGSVICLELVNRLVYSGSADRTV 257
Query: 1742 ELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQL--AFQ-HT 1798
+ W G V AH+ ++ L L T C + +D G+L F+ HT
Sbjct: 258 KCWLADTGECVRTFTAHRRNVSA--LKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHT 315
Query: 1799 YPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVA 1858
+ +NC+ H GQV+ T S G++ + V GL+ P S+ L N G A
Sbjct: 316 F--IINCIQVH--GQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSRLFSNKVGCAAA 371
>gi|189571685 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 86.7 bits (213), Expect = 3e-16
Identities = 83/305 (27%), Positives = 135/305 (44%), Gaps = 29/305 (9%)
Query: 2019 ATSQELLASASEDFTVQLWP-RQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLA 2077
A S LLA+ S D T++L+ R PH + L+ H V CC FS G LA
Sbjct: 19 AFSFSLLATCSLDKTIRLYSLRDFTELPH--------SPLKFHTYAVHCCCFSPSGHILA 70
Query: 2078 TGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNL-LISCSSDGSVGLWDPE 2136
+ D + + W+ + ++ V C ++ D+ L S ++DG+V LW+ +
Sbjct: 71 SCSTDGTTVLWNTENGQMLAVMEQPSGSP---VRVCQFSPDSTCLASGAADGTVVLWNAQ 127
Query: 2137 SGQ--RLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCA 2194
S + R G A A + V+ S G L VWD + L S AH I+ C
Sbjct: 128 SYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDLGITCCD 187
Query: 2195 AAMEPRAAGQPGSELL-VVTVGLDGATRLWHPLLVCQTH----------TLLGHSGPVRA 2243
+ +P + G+ G + + + G D ++W +V TH TL GH PV A
Sbjct: 188 FSSQPVSDGEQGLQFFRLASCGQDCQVKIW---IVSFTHILGFELKYKSTLSGHCAPVLA 244
Query: 2244 AAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGE 2303
A S ++++ S D SV ++ E + + + VT A+AP+ + +G+
Sbjct: 245 CAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKT 304
Query: 2304 LILWQ 2308
+ +WQ
Sbjct: 305 VNIWQ 309
Score = 74.3 bits (181), Expect = 1e-12
Identities = 81/317 (25%), Positives = 134/317 (42%), Gaps = 25/317 (7%)
Query: 1832 LKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPA--HHGFVAA 1889
+K+ L G + AF+ ++A LD + L++ R+ L P H V
Sbjct: 2 VKLIHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHC 59
Query: 1890 ALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRAD 1949
F +G L + DG +W+ G+ + S SP SPD +A G
Sbjct: 60 CCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADG 119
Query: 1950 GIRIYKISSGSQGAQGQALDVAVSALAWLSP--KVLVSGAEDGSLQGWALKECSLQS--- 2004
+ ++ S G D +++A A+ SP V+G+ G L W K L S
Sbjct: 120 TVVLWNAQSYKLYRCGSVKDGSLAACAF-SPNGSFFVTGSSCGDLTVWDDKMRCLHSEKA 178
Query: 2005 ----LWLLSRFQKPVLGLATSQEL--LASASEDFTVQLWPRQLLTRPH-KAEDFPCGTEL 2057
+ +PV + LAS +D V++W +++ H + + L
Sbjct: 179 HDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW---IVSFTHILGFELKYKSTL 235
Query: 2058 RGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTK 2117
GH PV C+FS DG L +G D+S++ +D T ++H+ H +VT CA+
Sbjct: 236 SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTEN---ILHTLTQ-HTRYVTTCAFAP 291
Query: 2118 DNLLISCSS-DGSVGLW 2133
+ LL++ S D +V +W
Sbjct: 292 NTLLLATGSMDKTVNIW 308
Score = 61.2 bits (147), Expect = 1e-08
Identities = 63/257 (24%), Positives = 104/257 (40%), Gaps = 24/257 (9%)
Query: 1719 DGISACLFLSDDTLFLTAFDGLLELWDLQHGCRVLQT--KAHQYQITGCCLSPDCRLLAT 1776
D ++ C F S L + D + L+ L+ + + K H Y + CC SP +LA+
Sbjct: 13 DDVNCCAF-SFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILAS 71
Query: 1777 VCLGGCLKLWDTVRGQLAFQHTYPKS--LNCVAFHPEGQVIATGSWAGSISFFQVDGLKV 1834
G LW+T GQ+ P + F P+ +A+G+ G++ + K+
Sbjct: 72 CSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKL 131
Query: 1835 TKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGAR-LAAFPAHHGFVAAALFL 1893
+ S+ AF+ G G S +L W + R L + AH + F
Sbjct: 132 YRCGSVKDGSLAACAFSPNGSFFVTG--SSCGDLTVWDDKMRCLHSEKAHDLGITCCDFS 189
Query: 1894 -------HAGCQ---LLTAGEDGKVQVWSGS----LGRPRGHLGSLS--LSPALSVALSP 1937
G Q L + G+D +V++W S LG + +LS +P L+ A S
Sbjct: 190 SQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSH 249
Query: 1938 DGDRVAVGYRADGIRIY 1954
DG + G + +Y
Sbjct: 250 DGQMLVSGSVDKSVIVY 266
Score = 51.2 bits (121), Expect = 1e-05
Identities = 58/227 (25%), Positives = 98/227 (43%), Gaps = 23/227 (10%)
Query: 1664 KNQQSSSLSLAVSSSPTAVA-FSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGIS 1722
+N Q ++ S SP V FS + A G A+GTV L + ++++ + ++
Sbjct: 84 ENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLA 143
Query: 1723 ACLFLSDDTLFLTAFD-GLLELWDLQHGCRVLQTKAHQYQITGCC------LSPDCRLLA 1775
AC F + + F+T G L +WD + C + KAH IT CC +S + L
Sbjct: 144 ACAFSPNGSFFVTGSSCGDLTVWDDKMRC-LHSEKAHDLGIT-CCDFSSQPVSDGEQGLQ 201
Query: 1776 TVCLGGC-----LKLWD-TVRGQLAFQHTYPKSLN-------CVAFHPEGQVIATGSWAG 1822
L C +K+W + L F+ Y +L+ AF +GQ++ +GS
Sbjct: 202 FFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDK 261
Query: 1823 SISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELW 1869
S+ + + + L + T AF ++A G +D V +W
Sbjct: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
Score = 47.0 bits (110), Expect = 2e-04
Identities = 28/101 (27%), Positives = 47/101 (46%), Gaps = 1/101 (0%)
Query: 2210 LVVTVGLDGATRLWHPLLVCQTHTLLGHSG-PVRAAAVSETSGLMLTASEDGSVRLWQVP 2268
++ + DG T LW+ + SG PVR S S + + + DG+V LW
Sbjct: 68 ILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQ 127
Query: 2269 KEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQE 2309
C ++ A A++P+GS V+G+ G+L +W +
Sbjct: 128 SYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDD 168
>gi|189571683 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 86.7 bits (213), Expect = 3e-16
Identities = 83/305 (27%), Positives = 135/305 (44%), Gaps = 29/305 (9%)
Query: 2019 ATSQELLASASEDFTVQLWP-RQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLA 2077
A S LLA+ S D T++L+ R PH + L+ H V CC FS G LA
Sbjct: 19 AFSFSLLATCSLDKTIRLYSLRDFTELPH--------SPLKFHTYAVHCCCFSPSGHILA 70
Query: 2078 TGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNL-LISCSSDGSVGLWDPE 2136
+ D + + W+ + ++ V C ++ D+ L S ++DG+V LW+ +
Sbjct: 71 SCSTDGTTVLWNTENGQMLAVMEQPSGSP---VRVCQFSPDSTCLASGAADGTVVLWNAQ 127
Query: 2137 SGQ--RLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCA 2194
S + R G A A + V+ S G L VWD + L S AH I+ C
Sbjct: 128 SYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDLGITCCD 187
Query: 2195 AAMEPRAAGQPGSELL-VVTVGLDGATRLWHPLLVCQTH----------TLLGHSGPVRA 2243
+ +P + G+ G + + + G D ++W +V TH TL GH PV A
Sbjct: 188 FSSQPVSDGEQGLQFFRLASCGQDCQVKIW---IVSFTHILGFELKYKSTLSGHCAPVLA 244
Query: 2244 AAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGE 2303
A S ++++ S D SV ++ E + + + VT A+AP+ + +G+
Sbjct: 245 CAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKT 304
Query: 2304 LILWQ 2308
+ +WQ
Sbjct: 305 VNIWQ 309
Score = 74.3 bits (181), Expect = 1e-12
Identities = 81/317 (25%), Positives = 134/317 (42%), Gaps = 25/317 (7%)
Query: 1832 LKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPA--HHGFVAA 1889
+K+ L G + AF+ ++A LD + L++ R+ L P H V
Sbjct: 2 VKLIHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHC 59
Query: 1890 ALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRAD 1949
F +G L + DG +W+ G+ + S SP SPD +A G
Sbjct: 60 CCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADG 119
Query: 1950 GIRIYKISSGSQGAQGQALDVAVSALAWLSP--KVLVSGAEDGSLQGWALKECSLQS--- 2004
+ ++ S G D +++A A+ SP V+G+ G L W K L S
Sbjct: 120 TVVLWNAQSYKLYRCGSVKDGSLAACAF-SPNGSFFVTGSSCGDLTVWDDKMRCLHSEKA 178
Query: 2005 ----LWLLSRFQKPVLGLATSQEL--LASASEDFTVQLWPRQLLTRPH-KAEDFPCGTEL 2057
+ +PV + LAS +D V++W +++ H + + L
Sbjct: 179 HDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW---IVSFTHILGFELKYKSTL 235
Query: 2058 RGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTK 2117
GH PV C+FS DG L +G D+S++ +D T ++H+ H +VT CA+
Sbjct: 236 SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTEN---ILHTLTQ-HTRYVTTCAFAP 291
Query: 2118 DNLLISCSS-DGSVGLW 2133
+ LL++ S D +V +W
Sbjct: 292 NTLLLATGSMDKTVNIW 308
Score = 61.2 bits (147), Expect = 1e-08
Identities = 63/257 (24%), Positives = 104/257 (40%), Gaps = 24/257 (9%)
Query: 1719 DGISACLFLSDDTLFLTAFDGLLELWDLQHGCRVLQT--KAHQYQITGCCLSPDCRLLAT 1776
D ++ C F S L + D + L+ L+ + + K H Y + CC SP +LA+
Sbjct: 13 DDVNCCAF-SFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILAS 71
Query: 1777 VCLGGCLKLWDTVRGQLAFQHTYPKS--LNCVAFHPEGQVIATGSWAGSISFFQVDGLKV 1834
G LW+T GQ+ P + F P+ +A+G+ G++ + K+
Sbjct: 72 CSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKL 131
Query: 1835 TKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGAR-LAAFPAHHGFVAAALFL 1893
+ S+ AF+ G G S +L W + R L + AH + F
Sbjct: 132 YRCGSVKDGSLAACAFSPNGSFFVTG--SSCGDLTVWDDKMRCLHSEKAHDLGITCCDFS 189
Query: 1894 -------HAGCQ---LLTAGEDGKVQVWSGS----LGRPRGHLGSLS--LSPALSVALSP 1937
G Q L + G+D +V++W S LG + +LS +P L+ A S
Sbjct: 190 SQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSH 249
Query: 1938 DGDRVAVGYRADGIRIY 1954
DG + G + +Y
Sbjct: 250 DGQMLVSGSVDKSVIVY 266
Score = 51.2 bits (121), Expect = 1e-05
Identities = 58/227 (25%), Positives = 98/227 (43%), Gaps = 23/227 (10%)
Query: 1664 KNQQSSSLSLAVSSSPTAVA-FSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGIS 1722
+N Q ++ S SP V FS + A G A+GTV L + ++++ + ++
Sbjct: 84 ENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLA 143
Query: 1723 ACLFLSDDTLFLTAFD-GLLELWDLQHGCRVLQTKAHQYQITGCC------LSPDCRLLA 1775
AC F + + F+T G L +WD + C + KAH IT CC +S + L
Sbjct: 144 ACAFSPNGSFFVTGSSCGDLTVWDDKMRC-LHSEKAHDLGIT-CCDFSSQPVSDGEQGLQ 201
Query: 1776 TVCLGGC-----LKLWD-TVRGQLAFQHTYPKSLN-------CVAFHPEGQVIATGSWAG 1822
L C +K+W + L F+ Y +L+ AF +GQ++ +GS
Sbjct: 202 FFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDK 261
Query: 1823 SISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELW 1869
S+ + + + L + T AF ++A G +D V +W
Sbjct: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
Score = 47.0 bits (110), Expect = 2e-04
Identities = 28/101 (27%), Positives = 47/101 (46%), Gaps = 1/101 (0%)
Query: 2210 LVVTVGLDGATRLWHPLLVCQTHTLLGHSG-PVRAAAVSETSGLMLTASEDGSVRLWQVP 2268
++ + DG T LW+ + SG PVR S S + + + DG+V LW
Sbjct: 68 ILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQ 127
Query: 2269 KEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQE 2309
C ++ A A++P+GS V+G+ G+L +W +
Sbjct: 128 SYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDD 168
>gi|189571681 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 86.7 bits (213), Expect = 3e-16
Identities = 83/305 (27%), Positives = 135/305 (44%), Gaps = 29/305 (9%)
Query: 2019 ATSQELLASASEDFTVQLWP-RQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLA 2077
A S LLA+ S D T++L+ R PH + L+ H V CC FS G LA
Sbjct: 19 AFSFSLLATCSLDKTIRLYSLRDFTELPH--------SPLKFHTYAVHCCCFSPSGHILA 70
Query: 2078 TGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNL-LISCSSDGSVGLWDPE 2136
+ D + + W+ + ++ V C ++ D+ L S ++DG+V LW+ +
Sbjct: 71 SCSTDGTTVLWNTENGQMLAVMEQPSGSP---VRVCQFSPDSTCLASGAADGTVVLWNAQ 127
Query: 2137 SGQ--RLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCA 2194
S + R G A A + V+ S G L VWD + L S AH I+ C
Sbjct: 128 SYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDLGITCCD 187
Query: 2195 AAMEPRAAGQPGSELL-VVTVGLDGATRLWHPLLVCQTH----------TLLGHSGPVRA 2243
+ +P + G+ G + + + G D ++W +V TH TL GH PV A
Sbjct: 188 FSSQPVSDGEQGLQFFRLASCGQDCQVKIW---IVSFTHILGFELKYKSTLSGHCAPVLA 244
Query: 2244 AAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGE 2303
A S ++++ S D SV ++ E + + + VT A+AP+ + +G+
Sbjct: 245 CAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKT 304
Query: 2304 LILWQ 2308
+ +WQ
Sbjct: 305 VNIWQ 309
Score = 74.3 bits (181), Expect = 1e-12
Identities = 81/317 (25%), Positives = 134/317 (42%), Gaps = 25/317 (7%)
Query: 1832 LKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPA--HHGFVAA 1889
+K+ L G + AF+ ++A LD + L++ R+ L P H V
Sbjct: 2 VKLIHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHC 59
Query: 1890 ALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRAD 1949
F +G L + DG +W+ G+ + S SP SPD +A G
Sbjct: 60 CCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADG 119
Query: 1950 GIRIYKISSGSQGAQGQALDVAVSALAWLSP--KVLVSGAEDGSLQGWALKECSLQS--- 2004
+ ++ S G D +++A A+ SP V+G+ G L W K L S
Sbjct: 120 TVVLWNAQSYKLYRCGSVKDGSLAACAF-SPNGSFFVTGSSCGDLTVWDDKMRCLHSEKA 178
Query: 2005 ----LWLLSRFQKPVLGLATSQEL--LASASEDFTVQLWPRQLLTRPH-KAEDFPCGTEL 2057
+ +PV + LAS +D V++W +++ H + + L
Sbjct: 179 HDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW---IVSFTHILGFELKYKSTL 235
Query: 2058 RGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTK 2117
GH PV C+FS DG L +G D+S++ +D T ++H+ H +VT CA+
Sbjct: 236 SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTEN---ILHTLTQ-HTRYVTTCAFAP 291
Query: 2118 DNLLISCSS-DGSVGLW 2133
+ LL++ S D +V +W
Sbjct: 292 NTLLLATGSMDKTVNIW 308
Score = 61.2 bits (147), Expect = 1e-08
Identities = 63/257 (24%), Positives = 104/257 (40%), Gaps = 24/257 (9%)
Query: 1719 DGISACLFLSDDTLFLTAFDGLLELWDLQHGCRVLQT--KAHQYQITGCCLSPDCRLLAT 1776
D ++ C F S L + D + L+ L+ + + K H Y + CC SP +LA+
Sbjct: 13 DDVNCCAF-SFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILAS 71
Query: 1777 VCLGGCLKLWDTVRGQLAFQHTYPKS--LNCVAFHPEGQVIATGSWAGSISFFQVDGLKV 1834
G LW+T GQ+ P + F P+ +A+G+ G++ + K+
Sbjct: 72 CSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKL 131
Query: 1835 TKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGAR-LAAFPAHHGFVAAALFL 1893
+ S+ AF+ G G S +L W + R L + AH + F
Sbjct: 132 YRCGSVKDGSLAACAFSPNGSFFVTG--SSCGDLTVWDDKMRCLHSEKAHDLGITCCDFS 189
Query: 1894 -------HAGCQ---LLTAGEDGKVQVWSGS----LGRPRGHLGSLS--LSPALSVALSP 1937
G Q L + G+D +V++W S LG + +LS +P L+ A S
Sbjct: 190 SQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSH 249
Query: 1938 DGDRVAVGYRADGIRIY 1954
DG + G + +Y
Sbjct: 250 DGQMLVSGSVDKSVIVY 266
Score = 51.2 bits (121), Expect = 1e-05
Identities = 58/227 (25%), Positives = 98/227 (43%), Gaps = 23/227 (10%)
Query: 1664 KNQQSSSLSLAVSSSPTAVA-FSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGIS 1722
+N Q ++ S SP V FS + A G A+GTV L + ++++ + ++
Sbjct: 84 ENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLA 143
Query: 1723 ACLFLSDDTLFLTAFD-GLLELWDLQHGCRVLQTKAHQYQITGCC------LSPDCRLLA 1775
AC F + + F+T G L +WD + C + KAH IT CC +S + L
Sbjct: 144 ACAFSPNGSFFVTGSSCGDLTVWDDKMRC-LHSEKAHDLGIT-CCDFSSQPVSDGEQGLQ 201
Query: 1776 TVCLGGC-----LKLWD-TVRGQLAFQHTYPKSLN-------CVAFHPEGQVIATGSWAG 1822
L C +K+W + L F+ Y +L+ AF +GQ++ +GS
Sbjct: 202 FFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDK 261
Query: 1823 SISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELW 1869
S+ + + + L + T AF ++A G +D V +W
Sbjct: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
Score = 47.0 bits (110), Expect = 2e-04
Identities = 28/101 (27%), Positives = 47/101 (46%), Gaps = 1/101 (0%)
Query: 2210 LVVTVGLDGATRLWHPLLVCQTHTLLGHSG-PVRAAAVSETSGLMLTASEDGSVRLWQVP 2268
++ + DG T LW+ + SG PVR S S + + + DG+V LW
Sbjct: 68 ILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQ 127
Query: 2269 KEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQE 2309
C ++ A A++P+GS V+G+ G+L +W +
Sbjct: 128 SYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDD 168
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 85.9 bits (211), Expect = 5e-16
Identities = 85/305 (27%), Positives = 139/305 (45%), Gaps = 41/305 (13%)
Query: 2057 LRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWV--TGCA 2114
L+GH+ V C G + +G D +L W T K C R V TG
Sbjct: 258 LKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGK----------CLRTLVGHTGGV 306
Query: 2115 WT---KDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLK 2171
W+ +DN++IS S+D ++ +W+ E+G+ + GH S V + E+ VVS SRD TL+
Sbjct: 307 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLR 366
Query: 2172 VWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQT 2231
VWD + + + + H AA + G+ VV+ D ++W P
Sbjct: 367 VWDIETGQCLHV-----LMGHVAAVRCVQYDGR-----RVVSGAYDFMVKVWDPETETCL 416
Query: 2232 HTLLGHSGPVRAAAVSETSGL-MLTASEDGSVRLWQVPKEADDTCIPRSSA--AVTAVAW 2288
HTL GH+ V + + G+ +++ S D S+R+W V CI + ++T+
Sbjct: 417 HTLQGHTNRVYSL---QFDGIHVVSGSLDTSIRVWDV---ETGNCIHTLTGHQSLTSGME 470
Query: 2289 APDGSMAVSGNQAGELILW--QEAKAVATAQAPG-HIGALIWSSAHTFFVL--SADEKIS 2343
D ++ VSGN + +W + + + T Q P H A+ + FV+ S D +
Sbjct: 471 LKD-NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVK 529
Query: 2344 EWQVK 2348
W +K
Sbjct: 530 LWDLK 534
Score = 51.2 bits (121), Expect = 1e-05
Identities = 67/295 (22%), Positives = 117/295 (39%), Gaps = 39/295 (13%)
Query: 1854 GGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSG 1913
G + G D+ +++W+ G L H G V ++ +++ D ++VW+
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNA 330
Query: 1914 SLGRP----RGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALD 1969
G GH ++ + RV G R +R++ I +G Q L
Sbjct: 331 ETGECIHTLYGHTSTVR-------CMHLHEKRVVSGSRDATLRVWDIETG------QCLH 377
Query: 1970 VAVSALAWL-----SPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQEL 2024
V + +A + + +VSGA D ++ W + + L L V L
Sbjct: 378 VLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPE--TETCLHTLQGHTNRVYSLQFDGIH 435
Query: 2025 LASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRS 2084
+ S S D ++++W E C L GH+ S L +G D +
Sbjct: 436 VVSGSLDTSIRVWD---------VETGNCIHTLTGHQSLTS--GMELKDNILVSGNADST 484
Query: 2085 LLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQ 2139
+ WD++T + + P H+ VT C N +I+ S DG+V LWD ++G+
Sbjct: 485 VKIWDIKTGQCLQTLQG-PNKHQSAVT-CLQFNKNFVITSSDDGTVKLWDLKTGE 537
Score = 35.0 bits (79), Expect = 0.98
Identities = 26/96 (27%), Positives = 45/96 (46%), Gaps = 11/96 (11%)
Query: 1705 LRTWQEEKS----VVSGCDGISACLFLSDDTLFLTAFDGLLELWDLQHGCRVLQT----K 1756
+R W E ++G +++ + L D+ L D +++WD++ G + LQT
Sbjct: 445 IRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG-QCLQTLQGPN 503
Query: 1757 AHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ 1792
HQ +T CL + + T G +KLWD G+
Sbjct: 504 KHQSAVT--CLQFNKNFVITSSDDGTVKLWDLKTGE 537
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 85.9 bits (211), Expect = 5e-16
Identities = 85/305 (27%), Positives = 139/305 (45%), Gaps = 41/305 (13%)
Query: 2057 LRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWV--TGCA 2114
L+GH+ V C G + +G D +L W T K C R V TG
Sbjct: 376 LKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGK----------CLRTLVGHTGGV 424
Query: 2115 WT---KDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLK 2171
W+ +DN++IS S+D ++ +W+ E+G+ + GH S V + E+ VVS SRD TL+
Sbjct: 425 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLR 484
Query: 2172 VWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQT 2231
VWD + + + + H AA + G+ VV+ D ++W P
Sbjct: 485 VWDIETGQCLHV-----LMGHVAAVRCVQYDGR-----RVVSGAYDFMVKVWDPETETCL 534
Query: 2232 HTLLGHSGPVRAAAVSETSGL-MLTASEDGSVRLWQVPKEADDTCIPRSSA--AVTAVAW 2288
HTL GH+ V + + G+ +++ S D S+R+W V CI + ++T+
Sbjct: 535 HTLQGHTNRVYSL---QFDGIHVVSGSLDTSIRVWDV---ETGNCIHTLTGHQSLTSGME 588
Query: 2289 APDGSMAVSGNQAGELILW--QEAKAVATAQAPG-HIGALIWSSAHTFFVL--SADEKIS 2343
D ++ VSGN + +W + + + T Q P H A+ + FV+ S D +
Sbjct: 589 LKD-NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVK 647
Query: 2344 EWQVK 2348
W +K
Sbjct: 648 LWDLK 652
Score = 51.2 bits (121), Expect = 1e-05
Identities = 67/295 (22%), Positives = 117/295 (39%), Gaps = 39/295 (13%)
Query: 1854 GGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSG 1913
G + G D+ +++W+ G L H G V ++ +++ D ++VW+
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNA 448
Query: 1914 SLGRP----RGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALD 1969
G GH ++ + RV G R +R++ I +G Q L
Sbjct: 449 ETGECIHTLYGHTSTVR-------CMHLHEKRVVSGSRDATLRVWDIETG------QCLH 495
Query: 1970 VAVSALAWL-----SPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQEL 2024
V + +A + + +VSGA D ++ W + + L L V L
Sbjct: 496 VLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPE--TETCLHTLQGHTNRVYSLQFDGIH 553
Query: 2025 LASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRS 2084
+ S S D ++++W E C L GH+ S L +G D +
Sbjct: 554 VVSGSLDTSIRVWD---------VETGNCIHTLTGHQSLTS--GMELKDNILVSGNADST 602
Query: 2085 LLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQ 2139
+ WD++T + + P H+ VT C N +I+ S DG+V LWD ++G+
Sbjct: 603 VKIWDIKTGQCLQTLQG-PNKHQSAVT-CLQFNKNFVITSSDDGTVKLWDLKTGE 655
Score = 35.0 bits (79), Expect = 0.98
Identities = 26/96 (27%), Positives = 45/96 (46%), Gaps = 11/96 (11%)
Query: 1705 LRTWQEEKS----VVSGCDGISACLFLSDDTLFLTAFDGLLELWDLQHGCRVLQT----K 1756
+R W E ++G +++ + L D+ L D +++WD++ G + LQT
Sbjct: 563 IRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG-QCLQTLQGPN 621
Query: 1757 AHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ 1792
HQ +T CL + + T G +KLWD G+
Sbjct: 622 KHQSAVT--CLQFNKNFVITSSDDGTVKLWDLKTGE 655
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 85.9 bits (211), Expect = 5e-16
Identities = 85/305 (27%), Positives = 139/305 (45%), Gaps = 41/305 (13%)
Query: 2057 LRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWV--TGCA 2114
L+GH+ V C G + +G D +L W T K C R V TG
Sbjct: 296 LKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGK----------CLRTLVGHTGGV 344
Query: 2115 WT---KDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLK 2171
W+ +DN++IS S+D ++ +W+ E+G+ + GH S V + E+ VVS SRD TL+
Sbjct: 345 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLR 404
Query: 2172 VWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQT 2231
VWD + + + + H AA + G+ VV+ D ++W P
Sbjct: 405 VWDIETGQCLHV-----LMGHVAAVRCVQYDGR-----RVVSGAYDFMVKVWDPETETCL 454
Query: 2232 HTLLGHSGPVRAAAVSETSGL-MLTASEDGSVRLWQVPKEADDTCIPRSSA--AVTAVAW 2288
HTL GH+ V + + G+ +++ S D S+R+W V CI + ++T+
Sbjct: 455 HTLQGHTNRVYSL---QFDGIHVVSGSLDTSIRVWDV---ETGNCIHTLTGHQSLTSGME 508
Query: 2289 APDGSMAVSGNQAGELILW--QEAKAVATAQAPG-HIGALIWSSAHTFFVL--SADEKIS 2343
D ++ VSGN + +W + + + T Q P H A+ + FV+ S D +
Sbjct: 509 LKD-NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVK 567
Query: 2344 EWQVK 2348
W +K
Sbjct: 568 LWDLK 572
Score = 51.2 bits (121), Expect = 1e-05
Identities = 67/295 (22%), Positives = 117/295 (39%), Gaps = 39/295 (13%)
Query: 1854 GGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSG 1913
G + G D+ +++W+ G L H G V ++ +++ D ++VW+
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNA 368
Query: 1914 SLGRP----RGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALD 1969
G GH ++ + RV G R +R++ I +G Q L
Sbjct: 369 ETGECIHTLYGHTSTVR-------CMHLHEKRVVSGSRDATLRVWDIETG------QCLH 415
Query: 1970 VAVSALAWL-----SPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQEL 2024
V + +A + + +VSGA D ++ W + + L L V L
Sbjct: 416 VLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPE--TETCLHTLQGHTNRVYSLQFDGIH 473
Query: 2025 LASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRS 2084
+ S S D ++++W E C L GH+ S L +G D +
Sbjct: 474 VVSGSLDTSIRVWD---------VETGNCIHTLTGHQSLTS--GMELKDNILVSGNADST 522
Query: 2085 LLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQ 2139
+ WD++T + + P H+ VT C N +I+ S DG+V LWD ++G+
Sbjct: 523 VKIWDIKTGQCLQTLQG-PNKHQSAVT-CLQFNKNFVITSSDDGTVKLWDLKTGE 575
Score = 35.0 bits (79), Expect = 0.98
Identities = 26/96 (27%), Positives = 45/96 (46%), Gaps = 11/96 (11%)
Query: 1705 LRTWQEEKS----VVSGCDGISACLFLSDDTLFLTAFDGLLELWDLQHGCRVLQT----K 1756
+R W E ++G +++ + L D+ L D +++WD++ G + LQT
Sbjct: 483 IRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG-QCLQTLQGPN 541
Query: 1757 AHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ 1792
HQ +T CL + + T G +KLWD G+
Sbjct: 542 KHQSAVT--CLQFNKNFVITSSDDGTVKLWDLKTGE 575
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 85.1 bits (209), Expect = 8e-16
Identities = 69/255 (27%), Positives = 120/255 (47%), Gaps = 26/255 (10%)
Query: 2019 ATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLAT 2078
++ LL SAS+D T+++W C L+GH V CC+F+ + +
Sbjct: 96 SSDSNLLVSASDDKTLKIWD---------VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 2079 GGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKD-NLLISCSSDGSVGLWDPES 2137
G D S+ WDV+T K + + PA H D V+ + +D +L++S S DG +WD S
Sbjct: 147 GSFDESVRIWDVKTGK---CLKTLPA-HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202
Query: 2138 GQRLGQFLGHQS-AVSAV--AAVEEHVVSVSRDGTLKVWDH-QGVELTSIPAHSGPISHC 2193
GQ L + + VS V + +++++ + D TLK+WD+ +G L + H +C
Sbjct: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE-KYC 261
Query: 2194 AAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLM 2253
A G+ +V+ D +W+ L GH+ V + A T ++
Sbjct: 262 IFANFSVTGGK-----WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316
Query: 2254 LTAS--EDGSVRLWQ 2266
+A+ D +++LW+
Sbjct: 317 ASAALENDKTIKLWK 331
Score = 84.3 bits (207), Expect = 1e-15
Identities = 76/283 (26%), Positives = 119/283 (42%), Gaps = 21/283 (7%)
Query: 2057 LRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWT 2116
L GH VS FS +G LA+ D+ + W K I H+ ++ AW+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG----HKLGISDVAWS 96
Query: 2117 KD-NLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEH--VVSVSRDGTLKVW 2173
D NLL+S S D ++ +WD SG+ L GH + V + +VS S D ++++W
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 2174 DHQ-GVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTH 2232
D + G L ++PAHS P+S A+ G L+V+ DG R+W
Sbjct: 157 DVKTGKCLKTLPAHSDPVS----AVHFNRDGS-----LIVSSSYDGLCRIWDTASGQCLK 207
Query: 2233 TLLGHSGP-VRAAAVSETSGLMLTASEDGSVRLWQVPKEA---DDTCIPRSSAAVTAVAW 2288
TL+ P V S +L A+ D +++LW K T + A
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS 267
Query: 2289 APDGSMAVSGNQAGELILWQEAKAVATAQAPGHIGALIWSSAH 2331
G VSG++ + +W + GH +I ++ H
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310
Score = 73.6 bits (179), Expect = 2e-12
Identities = 61/264 (23%), Positives = 117/264 (44%), Gaps = 11/264 (4%)
Query: 1658 NKPRTMKNQQSSSLSLAV-SSSPTAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVS 1716
+KP +K + +LA + + ++V FS NG+ A +A+ + + + EK++
Sbjct: 26 SKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 85
Query: 1717 GCDGISACLFLSDDTLFLTAFDG-LLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLA 1775
GIS + SD L ++A D L++WD+ G + K H + C +P L+
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
Query: 1776 TVCLGGCLKLWDTVRGQ-LAFQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDG--- 1831
+ +++WD G+ L + ++ V F+ +G +I + S+ G +
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205
Query: 1832 LKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHG---FVA 1888
LK D P S + F+ G + LD+ ++LW + +G L + H +
Sbjct: 206 LKTLIDDDNPPVSF--VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 263
Query: 1889 AALFLHAGCQLLTAGEDGKVQVWS 1912
A + G +++ ED V +W+
Sbjct: 264 ANFSVTGGKWIVSGSEDNLVYIWN 287
Score = 69.7 bits (169), Expect = 4e-11
Identities = 70/253 (27%), Positives = 110/253 (43%), Gaps = 30/253 (11%)
Query: 2023 ELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRD 2082
E LAS+S D +++W A D + GH+ +S ++S+D L + D
Sbjct: 58 EWLASSSADKLIKIWG---------AYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDD 108
Query: 2083 RSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWT-KDNLLISCSSDGSVGLWDPESGQRL 2141
++L WDV + K + H ++V C + + NL++S S D SV +WD ++G+ L
Sbjct: 109 KTLKIWDVSSGKCLKTLKG----HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL 164
Query: 2142 GQFLGHQSAVSAVAAVEEH--VVSVSRDGTLKVWDHQGVEL--TSIPAHSGPISHCAAAM 2197
H VSAV + +VS S DG ++WD + T I + P+S +
Sbjct: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224
Query: 2198 EPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRA--AAVSETSG-LML 2254
G +L T LD +LW T GH A S T G ++
Sbjct: 225 N-------GKYILAAT--LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 2255 TASEDGSVRLWQV 2267
+ SED V +W +
Sbjct: 276 SGSEDNLVYIWNL 288
Score = 64.7 bits (156), Expect = 1e-09
Identities = 63/292 (21%), Positives = 123/292 (42%), Gaps = 17/292 (5%)
Query: 1758 HQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHT---YPKSLNCVAFHPEGQV 1814
H ++ SP+ LA+ +K+W G+ F+ T + ++ VA+ + +
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGISDVAWSSDSNL 101
Query: 1815 IATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREG 1874
+ + S ++ + V K K L + FN ++ G D V +W + G
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 1875 ARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVA 1934
L PAH V+A F G ++++ DG ++W + G+ L P V
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221
Query: 1935 LSPDGDRVAVGYRADGIRIYKISSGS-----QGAQGQALDVAVSALAWLSPKVLVSGAED 1989
SP+G + + ++++ S G G + + + + + K +VSG+ED
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN-FSVTGGKWIVSGSED 280
Query: 1990 GSLQGWALKECSLQSLWLLSRFQKPVLGLA--TSQELLASAS--EDFTVQLW 2037
+ W L+ + + + L V+ A ++ ++ASA+ D T++LW
Sbjct: 281 NLVYIWNLQ--TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 57.8 bits (138), Expect = 1e-07
Identities = 60/266 (22%), Positives = 106/266 (39%), Gaps = 9/266 (3%)
Query: 1738 DGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ-LAFQ 1796
D L+++W G H+ I+ S D LL + LK+WD G+ L
Sbjct: 66 DKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125
Query: 1797 HTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGV 1856
+ + C F+P+ +I +GS+ S+ + V K K L A + + FN G +
Sbjct: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
Query: 1857 VAVGRLDSMVELWAWREGARL-AAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSL 1915
+ D + +W G L + V+ F G +L A D +++W S
Sbjct: 186 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
Query: 1916 GR-PRGHLGSLSLSPALSVALSPDGDRVAVGYRADG-IRIYKISSGS--QGAQGQALDVA 1971
G+ + + G + + S G + V D + I+ + + Q QG DV
Sbjct: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT-DVV 304
Query: 1972 VSALAWLSPKVLVSGA--EDGSLQGW 1995
+S + ++ S A D +++ W
Sbjct: 305 ISTACHPTENIIASAALENDKTIKLW 330
Score = 41.2 bits (95), Expect = 0.014
Identities = 27/123 (21%), Positives = 49/123 (39%), Gaps = 4/123 (3%)
Query: 2233 TLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDG 2292
TL GH+ V + S + ++S D +++W + I ++ VAW+ D
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 2293 SMAVSGNQAGELILWQEAKAVATAQAPGHIGALIWSS----AHTFFVLSADEKISEWQVK 2348
++ VS + L +W + GH + + ++ S DE + W VK
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 2349 LRK 2351
K
Sbjct: 160 TGK 162
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 85.1 bits (209), Expect = 8e-16
Identities = 69/255 (27%), Positives = 120/255 (47%), Gaps = 26/255 (10%)
Query: 2019 ATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLAT 2078
++ LL SAS+D T+++W C L+GH V CC+F+ + +
Sbjct: 96 SSDSNLLVSASDDKTLKIWD---------VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 2079 GGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKD-NLLISCSSDGSVGLWDPES 2137
G D S+ WDV+T K + + PA H D V+ + +D +L++S S DG +WD S
Sbjct: 147 GSFDESVRIWDVKTGK---CLKTLPA-HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202
Query: 2138 GQRLGQFLGHQS-AVSAV--AAVEEHVVSVSRDGTLKVWDH-QGVELTSIPAHSGPISHC 2193
GQ L + + VS V + +++++ + D TLK+WD+ +G L + H +C
Sbjct: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE-KYC 261
Query: 2194 AAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLM 2253
A G+ +V+ D +W+ L GH+ V + A T ++
Sbjct: 262 IFANFSVTGGK-----WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316
Query: 2254 LTAS--EDGSVRLWQ 2266
+A+ D +++LW+
Sbjct: 317 ASAALENDKTIKLWK 331
Score = 84.3 bits (207), Expect = 1e-15
Identities = 76/283 (26%), Positives = 119/283 (42%), Gaps = 21/283 (7%)
Query: 2057 LRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWT 2116
L GH VS FS +G LA+ D+ + W K I H+ ++ AW+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG----HKLGISDVAWS 96
Query: 2117 KD-NLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEH--VVSVSRDGTLKVW 2173
D NLL+S S D ++ +WD SG+ L GH + V + +VS S D ++++W
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 2174 DHQ-GVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTH 2232
D + G L ++PAHS P+S A+ G L+V+ DG R+W
Sbjct: 157 DVKTGKCLKTLPAHSDPVS----AVHFNRDGS-----LIVSSSYDGLCRIWDTASGQCLK 207
Query: 2233 TLLGHSGP-VRAAAVSETSGLMLTASEDGSVRLWQVPKEA---DDTCIPRSSAAVTAVAW 2288
TL+ P V S +L A+ D +++LW K T + A
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS 267
Query: 2289 APDGSMAVSGNQAGELILWQEAKAVATAQAPGHIGALIWSSAH 2331
G VSG++ + +W + GH +I ++ H
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310
Score = 73.6 bits (179), Expect = 2e-12
Identities = 61/264 (23%), Positives = 117/264 (44%), Gaps = 11/264 (4%)
Query: 1658 NKPRTMKNQQSSSLSLAV-SSSPTAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVS 1716
+KP +K + +LA + + ++V FS NG+ A +A+ + + + EK++
Sbjct: 26 SKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 85
Query: 1717 GCDGISACLFLSDDTLFLTAFDG-LLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLA 1775
GIS + SD L ++A D L++WD+ G + K H + C +P L+
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
Query: 1776 TVCLGGCLKLWDTVRGQ-LAFQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDG--- 1831
+ +++WD G+ L + ++ V F+ +G +I + S+ G +
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205
Query: 1832 LKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHG---FVA 1888
LK D P S + F+ G + LD+ ++LW + +G L + H +
Sbjct: 206 LKTLIDDDNPPVSF--VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 263
Query: 1889 AALFLHAGCQLLTAGEDGKVQVWS 1912
A + G +++ ED V +W+
Sbjct: 264 ANFSVTGGKWIVSGSEDNLVYIWN 287
Score = 69.7 bits (169), Expect = 4e-11
Identities = 70/253 (27%), Positives = 110/253 (43%), Gaps = 30/253 (11%)
Query: 2023 ELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRD 2082
E LAS+S D +++W A D + GH+ +S ++S+D L + D
Sbjct: 58 EWLASSSADKLIKIWG---------AYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDD 108
Query: 2083 RSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWT-KDNLLISCSSDGSVGLWDPESGQRL 2141
++L WDV + K + H ++V C + + NL++S S D SV +WD ++G+ L
Sbjct: 109 KTLKIWDVSSGKCLKTLKG----HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL 164
Query: 2142 GQFLGHQSAVSAVAAVEEH--VVSVSRDGTLKVWDHQGVEL--TSIPAHSGPISHCAAAM 2197
H VSAV + +VS S DG ++WD + T I + P+S +
Sbjct: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224
Query: 2198 EPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRA--AAVSETSG-LML 2254
G +L T LD +LW T GH A S T G ++
Sbjct: 225 N-------GKYILAAT--LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 2255 TASEDGSVRLWQV 2267
+ SED V +W +
Sbjct: 276 SGSEDNLVYIWNL 288
Score = 64.7 bits (156), Expect = 1e-09
Identities = 63/292 (21%), Positives = 123/292 (42%), Gaps = 17/292 (5%)
Query: 1758 HQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHT---YPKSLNCVAFHPEGQV 1814
H ++ SP+ LA+ +K+W G+ F+ T + ++ VA+ + +
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGISDVAWSSDSNL 101
Query: 1815 IATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREG 1874
+ + S ++ + V K K L + FN ++ G D V +W + G
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 1875 ARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVA 1934
L PAH V+A F G ++++ DG ++W + G+ L P V
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221
Query: 1935 LSPDGDRVAVGYRADGIRIYKISSGS-----QGAQGQALDVAVSALAWLSPKVLVSGAED 1989
SP+G + + ++++ S G G + + + + + K +VSG+ED
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN-FSVTGGKWIVSGSED 280
Query: 1990 GSLQGWALKECSLQSLWLLSRFQKPVLGLA--TSQELLASAS--EDFTVQLW 2037
+ W L+ + + + L V+ A ++ ++ASA+ D T++LW
Sbjct: 281 NLVYIWNLQ--TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 57.8 bits (138), Expect = 1e-07
Identities = 60/266 (22%), Positives = 106/266 (39%), Gaps = 9/266 (3%)
Query: 1738 DGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ-LAFQ 1796
D L+++W G H+ I+ S D LL + LK+WD G+ L
Sbjct: 66 DKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125
Query: 1797 HTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGV 1856
+ + C F+P+ +I +GS+ S+ + V K K L A + + FN G +
Sbjct: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
Query: 1857 VAVGRLDSMVELWAWREGARL-AAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSL 1915
+ D + +W G L + V+ F G +L A D +++W S
Sbjct: 186 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
Query: 1916 GR-PRGHLGSLSLSPALSVALSPDGDRVAVGYRADG-IRIYKISSGS--QGAQGQALDVA 1971
G+ + + G + + S G + V D + I+ + + Q QG DV
Sbjct: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT-DVV 304
Query: 1972 VSALAWLSPKVLVSGA--EDGSLQGW 1995
+S + ++ S A D +++ W
Sbjct: 305 ISTACHPTENIIASAALENDKTIKLW 330
Score = 41.2 bits (95), Expect = 0.014
Identities = 27/123 (21%), Positives = 49/123 (39%), Gaps = 4/123 (3%)
Query: 2233 TLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDG 2292
TL GH+ V + S + ++S D +++W + I ++ VAW+ D
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 2293 SMAVSGNQAGELILWQEAKAVATAQAPGHIGALIWSS----AHTFFVLSADEKISEWQVK 2348
++ VS + L +W + GH + + ++ S DE + W VK
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 2349 LRK 2351
K
Sbjct: 160 TGK 162
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 84.3 bits (207), Expect = 1e-15
Identities = 70/325 (21%), Positives = 140/325 (43%), Gaps = 15/325 (4%)
Query: 1680 TAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSD--DTLFLTAF 1737
T VA + +G G+ + T L D + +E ++ + + A F + D + +F
Sbjct: 96 TNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSF 155
Query: 1738 DGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQ- 1796
D +LW ++ G + H +I +P L+AT + KLWD G+ +
Sbjct: 156 DKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL 215
Query: 1797 HTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGV 1856
+ + ++F+ G I TGS+ ++ + D + L A I + +FN +
Sbjct: 216 RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSL 275
Query: 1857 VAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGS-- 1914
+ G +D +LW G +A H + + F + G + TA DG +++S +
Sbjct: 276 ILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR 335
Query: 1915 --LGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGS--QGAQGQALDV 1970
+ + GH G +S ++ +P G+ + G RI+ +G Q +G ++
Sbjct: 336 KCIAKLEGHEGEIS-----KISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEI 390
Query: 1971 AVSALAWLSPKVLVSGAEDGSLQGW 1995
A + ++++G++D + + W
Sbjct: 391 FSCAFNY-KGNIVITGSKDNTCRIW 414
Score = 82.4 bits (202), Expect = 5e-15
Identities = 86/385 (22%), Positives = 154/385 (40%), Gaps = 66/385 (17%)
Query: 1756 KAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ-LAFQHTYPKSLNCVAFH-PEGQ 1813
KAH +T L+ T KLWDT G+ L + + +AF+ P G
Sbjct: 89 KAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGD 148
Query: 1814 VIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWRE 1873
IATGS+ + + V+ K A I L+FN +VA G +D+ +LW +
Sbjct: 149 KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN 208
Query: 1874 GARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSV 1933
G + RGH + +S+
Sbjct: 209 GEEVYTL--------------------------------------RGHSAEI-----ISL 225
Query: 1934 ALSPDGDRVAVGYRADGIRIYKISSGSQG--AQGQALDVAVSALAWLSPKVLVSGAEDGS 1991
+ + GDR+ G + ++ +G + G +++ ++ W ++++G+ D +
Sbjct: 226 SFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNW-DCSLILTGSMDKT 284
Query: 1992 LQGWALKECSLQSLWLLSRFQKPVLGLATSQ--ELLASASEDFTVQLWPRQLLTRPHKAE 2049
+ W + + + L+ +L +L+A+AS D T +++ A
Sbjct: 285 CKLW--DATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF---------SAA 333
Query: 2050 DFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDW 2109
C +L GHEG +S SF+ G L TG D++ WD +T + ++ H D
Sbjct: 334 TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEG----HTDE 389
Query: 2110 VTGCAWT-KDNLLISCSSDGSVGLW 2133
+ CA+ K N++I+ S D + +W
Sbjct: 390 IFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 80.1 bits (196), Expect = 3e-14
Identities = 80/348 (22%), Positives = 148/348 (42%), Gaps = 36/348 (10%)
Query: 1929 PALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSP--KVLVSG 1986
P +VAL+ G G +++ +SG + + V A+A+ +P + +G
Sbjct: 94 PLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATG 153
Query: 1987 AEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPH 2046
+ D + + W+++ + + L L+A+ S D T +LW
Sbjct: 154 SFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW--------- 204
Query: 2047 KAEDFPCGTE---LRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTP-KTPVLIHSF 2102
D G E LRGH + SF+T G + TG D +++ WD T K +LI
Sbjct: 205 ---DIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIG-- 259
Query: 2103 PACHRDWVTGCAWTKD-NLLISCSSDGSVGLWDPESGQRLGQFLGHQSAV--SAVAAVEE 2159
H ++ ++ D +L+++ S D + LWD +G+ + GH + S +
Sbjct: 260 ---HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK 316
Query: 2160 HVVSVSRDGTLKVWDHQGVE-LTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDG 2218
+ + S DGT +++ + + + H G IS + P+ G+ LL T D
Sbjct: 317 LIATASADGTARIFSAATRKCIAKLEGHEGEISKIS--FNPQ-----GNHLL--TGSSDK 367
Query: 2219 ATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQ 2266
R+W L GH+ + + A + +++T S+D + R+W+
Sbjct: 368 TARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 75.5 bits (184), Expect = 7e-13
Identities = 72/312 (23%), Positives = 123/312 (39%), Gaps = 29/312 (9%)
Query: 2016 LGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELR---GHEGPVSCCSFSTD 2072
+ L S + S D T +LW D G EL GH V +F+
Sbjct: 98 VALNKSGSCFITGSYDRTCKLW------------DTASGEELNTLEGHRNVVYAIAFNNP 145
Query: 2073 -GGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVG 2131
G +ATG D++ W V T K H+F + V + L+ + S D +
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKC---YHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAK 202
Query: 2132 LWDPESGQRLGQFLGHQSAVSAVA--AVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGP 2189
LWD ++G+ + GH + + +++ + +++ S D T+ VWD +I
Sbjct: 203 LWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL----- 257
Query: 2190 ISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSET 2249
I HCA E +A L++T +D +LW TL GH + + T
Sbjct: 258 IGHCA---EISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314
Query: 2250 SGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQE 2309
L+ TAS DG+ R++ + ++ +++ P G+ ++G+ +W
Sbjct: 315 GKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDA 374
Query: 2310 AKAVATAQAPGH 2321
GH
Sbjct: 375 QTGQCLQVLEGH 386
Score = 70.1 bits (170), Expect = 3e-11
Identities = 49/196 (25%), Positives = 90/196 (45%), Gaps = 2/196 (1%)
Query: 1676 SSSPTAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLT 1735
S+ +++F+T+G R G+ + TV + D T ++ ++ C IS+ F D +L LT
Sbjct: 219 SAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILT 278
Query: 1736 -AFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWD-TVRGQL 1793
+ D +LWD +G V H +I C +L+AT G +++ R +
Sbjct: 279 GSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCI 338
Query: 1794 AFQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVP 1853
A + ++ ++F+P+G + TGS + + + + L I + AFN
Sbjct: 339 AKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYK 398
Query: 1854 GGVVAVGRLDSMVELW 1869
G +V G D+ +W
Sbjct: 399 GNIVITGSKDNTCRIW 414
Score = 62.4 bits (150), Expect = 6e-09
Identities = 58/274 (21%), Positives = 111/274 (40%), Gaps = 18/274 (6%)
Query: 2057 LRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWT 2116
L+ H P++ + + G TG DR+ WD + + + HR+ V A+
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEG----HRNVVYAIAFN 143
Query: 2117 K--DNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEH--VVSVSRDGTLKV 2172
+ + + S D + LW E+G+ F GH + + ++ + V + S D T K+
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
Query: 2173 WDHQ-GVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQT 2231
WD Q G E+ ++ HS I ++ +G ++T D +W +
Sbjct: 204 WDIQNGEEVYTLRGHSAEI----ISLSFNTSGD-----RIITGSFDHTVVVWDADTGRKV 254
Query: 2232 HTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPD 2291
+ L+GH + +A+ + L+LT S D + +LW + + +
Sbjct: 255 NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314
Query: 2292 GSMAVSGNQAGELILWQEAKAVATAQAPGHIGAL 2325
G + + + G ++ A A+ GH G +
Sbjct: 315 GKLIATASADGTARIFSAATRKCIAKLEGHEGEI 348
Score = 61.2 bits (147), Expect = 1e-08
Identities = 61/278 (21%), Positives = 112/278 (40%), Gaps = 27/278 (9%)
Query: 2122 ISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVA---AVEEHVVSVSRDGTLKVWDHQ-G 2177
I+ S D + LWD SG+ L GH++ V A+A + + + S D T K+W + G
Sbjct: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG 167
Query: 2178 VELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGH 2237
+ H+ I + P++ LV T +D +LW + +TL GH
Sbjct: 168 KCYHTFRGHTAEI--VCLSFNPQST-------LVATGSMDTTAKLWDIQNGEEVYTLRGH 218
Query: 2238 SGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVS 2297
S + + + + + ++T S D +V +W + A +++ ++ D S+ ++
Sbjct: 219 SAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILT 278
Query: 2298 GNQAGELILWQEAKAVATAQAPGHIGALIWS----SAHTFFVLSADEKISEWQVKLRKGS 2353
G+ LW A GH ++ S + SAD + RK
Sbjct: 279 GSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCI 338
Query: 2354 APGNLSLHLNRILQEDLGVLTSLDWAPDGHFLILAKAD 2391
A L+ G ++ + + P G+ L+ +D
Sbjct: 339 AK----------LEGHEGEISKISFNPQGNHLLTGSSD 366
>gi|4502477 beta-transducin repeat containing protein isoform 2 [Homo
sapiens]
Length = 569
Score = 82.8 bits (203), Expect = 4e-15
Identities = 77/292 (26%), Positives = 127/292 (43%), Gaps = 39/292 (13%)
Query: 1995 WALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCG 2054
W SLQ + S K V L + + S D T+++W + L C
Sbjct: 250 WRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTL---------ECK 300
Query: 2055 TELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPK-TPVLIHSFPACHRDWVTGC 2113
L GH G V C + D + TG D ++ WDV T + LIH H + V
Sbjct: 301 RILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNTLIH-----HCEAVLHL 353
Query: 2114 AWTKDNLLISCSSDGSVGLWDPESGQRL---GQFLGHQSAVSAVAAVEEHVVSVSRDGTL 2170
+ + ++++CS D S+ +WD S + +GH++AV+ V ++++VS S D T+
Sbjct: 354 RF-NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTI 412
Query: 2171 KVWDHQGVE-LTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVC 2229
KVW+ E + ++ H I A ++ R + LVV+ D RLW
Sbjct: 413 KVWNTSTCEFVRTLNGHKRGI----ACLQYR-------DRLVVSGSSDNTIRLWDIECGA 461
Query: 2230 QTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSA 2281
L GH VR + + +++ + DG +++W + D PR+ A
Sbjct: 462 CLRVLEGHEELVR--CIRFDNKRIVSGAYDGKIKVWDLVAALD----PRAPA 507
Score = 68.6 bits (166), Expect = 8e-11
Identities = 66/285 (23%), Positives = 118/285 (41%), Gaps = 58/285 (20%)
Query: 1981 KVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQ 2040
+V+++G+ D +++ W + + L L + VL L + ++ + S+D ++ +W
Sbjct: 318 RVIITGSSDSTVRVWDVNTGEM--LNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMA 375
Query: 2041 LLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIH 2100
T D L GH V+ F D + + DR++ W+ T + ++
Sbjct: 376 SPT------DITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLN 427
Query: 2101 SFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEH 2160
H+ + C +D L++S SSD ++ LWD E G L GH+ V + +
Sbjct: 428 G----HKRGIA-CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR 482
Query: 2161 VVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGAT 2220
+VS + DG +KVWD AA++PRA P L +
Sbjct: 483 IVSGAYDGKIKVWD------------------LVAALDPRA---PAGTLCL--------- 512
Query: 2221 RLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLW 2265
TL+ HSG V E ++++S D ++ +W
Sbjct: 513 -----------RTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIW 544
Score = 60.8 bits (146), Expect = 2e-08
Identities = 56/242 (23%), Positives = 100/242 (41%), Gaps = 16/242 (6%)
Query: 2072 DGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVG 2131
D + +G RD ++ WD T + ++ H V C + ++I+ SSD +V
Sbjct: 276 DDQKIVSGLRDNTIKIWDKNTLECKRILTG----HTGSVL-CLQYDERVIITGSSDSTVR 330
Query: 2132 LWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPIS 2191
+WD +G+ L + H AV + +V+ S+D ++ VWD T I +
Sbjct: 331 VWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDM--ASPTDITLRRVLVG 388
Query: 2192 HCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSG 2251
H AA + +V+ D ++W+ TL GH + A +
Sbjct: 389 HRAAVNV-----VDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQYRDR 441
Query: 2252 LMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQEAK 2311
L+++ S D ++RLW + A + V + + D VSG G++ +W
Sbjct: 442 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVA 499
Query: 2312 AV 2313
A+
Sbjct: 500 AL 501
Score = 43.9 bits (102), Expect = 0.002
Identities = 55/247 (22%), Positives = 99/247 (40%), Gaps = 20/247 (8%)
Query: 1689 QRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLLELWDLQH 1748
Q+ G + T+ + D T E K +++G G CL + + + D + +WD+
Sbjct: 278 QKIVSGLRDNTIKIWDKNTL-ECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNT 336
Query: 1749 GCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWD-------TVRGQLAFQHTYPK 1801
G +L T H + L + ++ T + +WD T+R L +
Sbjct: 337 G-EMLNTLIHHCEAV-LHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLV---GHRA 391
Query: 1802 SLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGR 1861
++N V F + + I + S +I + + + L I L + +V G
Sbjct: 392 AVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGS 447
Query: 1862 LDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWS-GSLGRPRG 1920
D+ + LW GA L H V F + ++++ DGK++VW + PR
Sbjct: 448 SDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK--RIVSGAYDGKIKVWDLVAALDPRA 505
Query: 1921 HLGSLSL 1927
G+L L
Sbjct: 506 PAGTLCL 512
>gi|16117783 beta-transducin repeat containing protein isoform 1 [Homo
sapiens]
Length = 605
Score = 82.8 bits (203), Expect = 4e-15
Identities = 77/292 (26%), Positives = 127/292 (43%), Gaps = 39/292 (13%)
Query: 1995 WALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCG 2054
W SLQ + S K V L + + S D T+++W + L C
Sbjct: 286 WRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTL---------ECK 336
Query: 2055 TELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPK-TPVLIHSFPACHRDWVTGC 2113
L GH G V C + D + TG D ++ WDV T + LIH H + V
Sbjct: 337 RILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNTLIH-----HCEAVLHL 389
Query: 2114 AWTKDNLLISCSSDGSVGLWDPESGQRL---GQFLGHQSAVSAVAAVEEHVVSVSRDGTL 2170
+ + ++++CS D S+ +WD S + +GH++AV+ V ++++VS S D T+
Sbjct: 390 RF-NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTI 448
Query: 2171 KVWDHQGVE-LTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVC 2229
KVW+ E + ++ H I A ++ R + LVV+ D RLW
Sbjct: 449 KVWNTSTCEFVRTLNGHKRGI----ACLQYR-------DRLVVSGSSDNTIRLWDIECGA 497
Query: 2230 QTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSA 2281
L GH VR + + +++ + DG +++W + D PR+ A
Sbjct: 498 CLRVLEGHEELVR--CIRFDNKRIVSGAYDGKIKVWDLVAALD----PRAPA 543
Score = 68.6 bits (166), Expect = 8e-11
Identities = 66/285 (23%), Positives = 118/285 (41%), Gaps = 58/285 (20%)
Query: 1981 KVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQ 2040
+V+++G+ D +++ W + + L L + VL L + ++ + S+D ++ +W
Sbjct: 354 RVIITGSSDSTVRVWDVNTGEM--LNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMA 411
Query: 2041 LLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIH 2100
T D L GH V+ F D + + DR++ W+ T + ++
Sbjct: 412 SPT------DITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLN 463
Query: 2101 SFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEH 2160
H+ + C +D L++S SSD ++ LWD E G L GH+ V + +
Sbjct: 464 G----HKRGIA-CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR 518
Query: 2161 VVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGAT 2220
+VS + DG +KVWD AA++PRA P L +
Sbjct: 519 IVSGAYDGKIKVWD------------------LVAALDPRA---PAGTLCL--------- 548
Query: 2221 RLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLW 2265
TL+ HSG V E ++++S D ++ +W
Sbjct: 549 -----------RTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIW 580
Score = 60.8 bits (146), Expect = 2e-08
Identities = 56/242 (23%), Positives = 100/242 (41%), Gaps = 16/242 (6%)
Query: 2072 DGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVG 2131
D + +G RD ++ WD T + ++ H V C + ++I+ SSD +V
Sbjct: 312 DDQKIVSGLRDNTIKIWDKNTLECKRILTG----HTGSVL-CLQYDERVIITGSSDSTVR 366
Query: 2132 LWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPIS 2191
+WD +G+ L + H AV + +V+ S+D ++ VWD T I +
Sbjct: 367 VWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDM--ASPTDITLRRVLVG 424
Query: 2192 HCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSG 2251
H AA + +V+ D ++W+ TL GH + A +
Sbjct: 425 HRAAVNV-----VDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQYRDR 477
Query: 2252 LMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQEAK 2311
L+++ S D ++RLW + A + V + + D VSG G++ +W
Sbjct: 478 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVA 535
Query: 2312 AV 2313
A+
Sbjct: 536 AL 537
Score = 43.9 bits (102), Expect = 0.002
Identities = 55/247 (22%), Positives = 99/247 (40%), Gaps = 20/247 (8%)
Query: 1689 QRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLLELWDLQH 1748
Q+ G + T+ + D T E K +++G G CL + + + D + +WD+
Sbjct: 314 QKIVSGLRDNTIKIWDKNTL-ECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNT 372
Query: 1749 GCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWD-------TVRGQLAFQHTYPK 1801
G +L T H + L + ++ T + +WD T+R L +
Sbjct: 373 G-EMLNTLIHHCEAV-LHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLV---GHRA 427
Query: 1802 SLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGR 1861
++N V F + + I + S +I + + + L I L + +V G
Sbjct: 428 AVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGS 483
Query: 1862 LDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWS-GSLGRPRG 1920
D+ + LW GA L H V F + ++++ DGK++VW + PR
Sbjct: 484 SDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK--RIVSGAYDGKIKVWDLVAALDPRA 541
Query: 1921 HLGSLSL 1927
G+L L
Sbjct: 542 PAGTLCL 548
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 82.8 bits (203), Expect = 4e-15
Identities = 79/303 (26%), Positives = 122/303 (40%), Gaps = 35/303 (11%)
Query: 1982 VLVSGAEDGSLQGWALKECSLQ-SLWLLSRF-----------QKPVLGLATSQE--LLAS 2027
+L SG+ D + + W L E S S L+ R K V L + + LLA
Sbjct: 193 LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAM 252
Query: 2028 ASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLC 2087
S D ++W E+ + L H+GP+ ++ G + + G D++ +
Sbjct: 253 GSYDGFARIW----------TENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTII 302
Query: 2088 WDVRT--PKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFL 2145
WD T K HS PA DW + SCS+D + + + F
Sbjct: 303 WDAHTGEAKQQFPFHSAPALDVDWQNNMTFA------SCSTDMCIHVCRLGCDHPVKTFQ 356
Query: 2146 GHQSAVSAVAAVEEHVV--SVSRDGTLKVWD-HQGVELTSIPAHSGPISHCAAAMEPRAA 2202
GH + V+A+ ++ S S D TLK+W Q + + AHS I + A
Sbjct: 357 GHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPAT 416
Query: 2203 GQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSV 2262
P S +++ + D RLW THTL+ H PV + A S + + S D V
Sbjct: 417 SNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYV 476
Query: 2263 RLW 2265
+W
Sbjct: 477 HIW 479
Score = 73.2 bits (178), Expect = 3e-12
Identities = 82/334 (24%), Positives = 131/334 (39%), Gaps = 62/334 (18%)
Query: 2055 TELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPK----TPVLI--------HSF 2102
T LRGHE V C+++ LA+G D + W++ T +++ H
Sbjct: 173 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
Query: 2103 PACHRDWVTGCAWTKDNLLISCSS-DGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEE-- 2159
P+ ++D VT W D L++ S DG +W E+G H+ + A+ ++
Sbjct: 233 PS-NKD-VTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 2160 HVVSVSRDGTLKVWD-HQGVELTSIPAHSGP-----------ISHCAAAM---------- 2197
+V+S D T +WD H G P HS P + C+ M
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
Query: 2198 -----------EPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHS-------- 2238
E A S +L+ + D ++W H L HS
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKW 409
Query: 2239 GPVRAAAVSETSGLML-TASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVS 2297
P A + S +ML +AS D +VRLW V + + + V +VA++PDG S
Sbjct: 410 SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLAS 469
Query: 2298 GNQAGELILW--QEAKAVATAQAPGHIGALIWSS 2329
G+ + +W Q V + Q G I + W++
Sbjct: 470 GSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNA 503
Score = 64.3 bits (155), Expect = 2e-09
Identities = 77/301 (25%), Positives = 128/301 (42%), Gaps = 28/301 (9%)
Query: 1845 IRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGE 1904
+ +L +N G ++A+G D +W G + H G + A + G +L+AG
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGV 296
Query: 1905 DGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRAD-GIRIYKISSGSQGA 1963
D +W G + S +PAL V + D I + ++
Sbjct: 297 DKTTIIWDAHTGEAKQQFPFHS-APALDV--DWQNNMTFASCSTDMCIHVCRLGCDHPVK 353
Query: 1964 QGQALDVAVSALAW-LSPKVLVSGAEDGSLQGWALK-ECSLQSLWLLSR----FQKPVLG 2017
Q V+A+ W S +L S ++D +L+ W++K + + L S+ + G
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTG 413
Query: 2018 LATSQE----LLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDG 2073
ATS +LASAS D TV+LW E C L H+ PV +FS DG
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLW---------DVEQGVCTHTLMKHQEPVYSVAFSPDG 464
Query: 2074 GSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLW 2133
LA+G D+ + W+ ++ L+HS+ + C + + + + +SDGSV +
Sbjct: 465 KYLASGSFDKYVHIWNTQSGS---LVHSYQGTGGIFEV-CWNARGDKVGASASDGSVCVL 520
Query: 2134 D 2134
D
Sbjct: 521 D 521
Score = 40.4 bits (93), Expect = 0.023
Identities = 21/89 (23%), Positives = 38/89 (42%)
Query: 1736 AFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAF 1795
+FD + LWD++ G HQ + SPD + LA+ + +W+T G L
Sbjct: 429 SFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVH 488
Query: 1796 QHTYPKSLNCVAFHPEGQVIATGSWAGSI 1824
+ + V ++ G + + GS+
Sbjct: 489 SYQGTGGIFEVCWNARGDKVGASASDGSV 517
Score = 37.4 bits (85), Expect = 0.20
Identities = 63/318 (19%), Positives = 117/318 (36%), Gaps = 44/318 (13%)
Query: 1756 KAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRG------QLAFQHTYP--------- 1800
+ H+ ++ C +P LLA+ ++W+ QL +H
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235
Query: 1801 KSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVG 1860
K + + ++ +G ++A GS+ G + +G + LG I L +N G V
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIWTENG-NLASTLGQHKGPIFALKWNKKGNYVLSA 294
Query: 1861 RLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRP-- 1918
+D +W G FP H A + + D + V P
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFP-FHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVK 353
Query: 1919 --RGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALA 1976
+GH ++ ++ P G +A ++I+ + + QA + +
Sbjct: 354 TFQGHTNEVN-----AIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIK 408
Query: 1977 WL----------SPKVLVSGAEDGSLQGWALKE--CSLQSLWLLSRFQKPVLGLATSQE- 2023
W S +L S + D +++ W +++ C+ L + Q+PV +A S +
Sbjct: 409 WSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCT----HTLMKHQEPVYSVAFSPDG 464
Query: 2024 -LLASASEDFTVQLWPRQ 2040
LAS S D V +W Q
Sbjct: 465 KYLASGSFDKYVHIWNTQ 482
Score = 32.7 bits (73), Expect = 4.8
Identities = 35/179 (19%), Positives = 69/179 (38%), Gaps = 17/179 (9%)
Query: 1748 HGCR------VLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQ-HTYP 1800
H CR V + H ++ P LLA+ LK+W + +
Sbjct: 342 HVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHS 401
Query: 1801 KSLNCVAFHPEGQ---------VIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFN 1851
K + + + P G ++A+ S+ ++ + V+ T L + ++AF+
Sbjct: 402 KEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFS 461
Query: 1852 VPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQV 1910
G +A G D V +W + G+ + ++ G + + G ++ + DG V V
Sbjct: 462 PDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGG-IFEVCWNARGDKVGASASDGSVCV 519
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 82.8 bits (203), Expect = 4e-15
Identities = 79/303 (26%), Positives = 122/303 (40%), Gaps = 35/303 (11%)
Query: 1982 VLVSGAEDGSLQGWALKECSLQ-SLWLLSRF-----------QKPVLGLATSQE--LLAS 2027
+L SG+ D + + W L E S S L+ R K V L + + LLA
Sbjct: 193 LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAM 252
Query: 2028 ASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLC 2087
S D ++W E+ + L H+GP+ ++ G + + G D++ +
Sbjct: 253 GSYDGFARIW----------TENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTII 302
Query: 2088 WDVRT--PKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFL 2145
WD T K HS PA DW + SCS+D + + + F
Sbjct: 303 WDAHTGEAKQQFPFHSAPALDVDWQNNMTFA------SCSTDMCIHVCRLGCDHPVKTFQ 356
Query: 2146 GHQSAVSAVAAVEEHVV--SVSRDGTLKVWD-HQGVELTSIPAHSGPISHCAAAMEPRAA 2202
GH + V+A+ ++ S S D TLK+W Q + + AHS I + A
Sbjct: 357 GHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPAT 416
Query: 2203 GQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSV 2262
P S +++ + D RLW THTL+ H PV + A S + + S D V
Sbjct: 417 SNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYV 476
Query: 2263 RLW 2265
+W
Sbjct: 477 HIW 479
Score = 73.2 bits (178), Expect = 3e-12
Identities = 82/334 (24%), Positives = 131/334 (39%), Gaps = 62/334 (18%)
Query: 2055 TELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPK----TPVLI--------HSF 2102
T LRGHE V C+++ LA+G D + W++ T +++ H
Sbjct: 173 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
Query: 2103 PACHRDWVTGCAWTKDNLLISCSS-DGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEE-- 2159
P+ ++D VT W D L++ S DG +W E+G H+ + A+ ++
Sbjct: 233 PS-NKD-VTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 2160 HVVSVSRDGTLKVWD-HQGVELTSIPAHSGP-----------ISHCAAAM---------- 2197
+V+S D T +WD H G P HS P + C+ M
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
Query: 2198 -----------EPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHS-------- 2238
E A S +L+ + D ++W H L HS
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKW 409
Query: 2239 GPVRAAAVSETSGLML-TASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVS 2297
P A + S +ML +AS D +VRLW V + + + V +VA++PDG S
Sbjct: 410 SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLAS 469
Query: 2298 GNQAGELILW--QEAKAVATAQAPGHIGALIWSS 2329
G+ + +W Q V + Q G I + W++
Sbjct: 470 GSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNA 503
Score = 64.3 bits (155), Expect = 2e-09
Identities = 77/301 (25%), Positives = 128/301 (42%), Gaps = 28/301 (9%)
Query: 1845 IRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGE 1904
+ +L +N G ++A+G D +W G + H G + A + G +L+AG
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGV 296
Query: 1905 DGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRAD-GIRIYKISSGSQGA 1963
D +W G + S +PAL V + D I + ++
Sbjct: 297 DKTTIIWDAHTGEAKQQFPFHS-APALDV--DWQNNMTFASCSTDMCIHVCRLGCDHPVK 353
Query: 1964 QGQALDVAVSALAW-LSPKVLVSGAEDGSLQGWALK-ECSLQSLWLLSR----FQKPVLG 2017
Q V+A+ W S +L S ++D +L+ W++K + + L S+ + G
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTG 413
Query: 2018 LATSQE----LLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDG 2073
ATS +LASAS D TV+LW E C L H+ PV +FS DG
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLW---------DVEQGVCTHTLMKHQEPVYSVAFSPDG 464
Query: 2074 GSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLW 2133
LA+G D+ + W+ ++ L+HS+ + C + + + + +SDGSV +
Sbjct: 465 KYLASGSFDKYVHIWNTQSGS---LVHSYQGTGGIFEV-CWNARGDKVGASASDGSVCVL 520
Query: 2134 D 2134
D
Sbjct: 521 D 521
Score = 40.4 bits (93), Expect = 0.023
Identities = 21/89 (23%), Positives = 38/89 (42%)
Query: 1736 AFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAF 1795
+FD + LWD++ G HQ + SPD + LA+ + +W+T G L
Sbjct: 429 SFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVH 488
Query: 1796 QHTYPKSLNCVAFHPEGQVIATGSWAGSI 1824
+ + V ++ G + + GS+
Sbjct: 489 SYQGTGGIFEVCWNARGDKVGASASDGSV 517
Score = 37.4 bits (85), Expect = 0.20
Identities = 63/318 (19%), Positives = 117/318 (36%), Gaps = 44/318 (13%)
Query: 1756 KAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRG------QLAFQHTYP--------- 1800
+ H+ ++ C +P LLA+ ++W+ QL +H
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235
Query: 1801 KSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVG 1860
K + + ++ +G ++A GS+ G + +G + LG I L +N G V
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIWTENG-NLASTLGQHKGPIFALKWNKKGNYVLSA 294
Query: 1861 RLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRP-- 1918
+D +W G FP H A + + D + V P
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFP-FHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVK 353
Query: 1919 --RGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALA 1976
+GH ++ ++ P G +A ++I+ + + QA + +
Sbjct: 354 TFQGHTNEVN-----AIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIK 408
Query: 1977 WL----------SPKVLVSGAEDGSLQGWALKE--CSLQSLWLLSRFQKPVLGLATSQE- 2023
W S +L S + D +++ W +++ C+ L + Q+PV +A S +
Sbjct: 409 WSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCT----HTLMKHQEPVYSVAFSPDG 464
Query: 2024 -LLASASEDFTVQLWPRQ 2040
LAS S D V +W Q
Sbjct: 465 KYLASGSFDKYVHIWNTQ 482
Score = 32.7 bits (73), Expect = 4.8
Identities = 35/179 (19%), Positives = 69/179 (38%), Gaps = 17/179 (9%)
Query: 1748 HGCR------VLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQ-HTYP 1800
H CR V + H ++ P LLA+ LK+W + +
Sbjct: 342 HVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHS 401
Query: 1801 KSLNCVAFHPEGQ---------VIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFN 1851
K + + + P G ++A+ S+ ++ + V+ T L + ++AF+
Sbjct: 402 KEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFS 461
Query: 1852 VPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQV 1910
G +A G D V +W + G+ + ++ G + + G ++ + DG V V
Sbjct: 462 PDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGG-IFEVCWNARGDKVGASASDGSVCV 519
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 82.8 bits (203), Expect = 4e-15
Identities = 79/303 (26%), Positives = 122/303 (40%), Gaps = 35/303 (11%)
Query: 1982 VLVSGAEDGSLQGWALKECSLQ-SLWLLSRF-----------QKPVLGLATSQE--LLAS 2027
+L SG+ D + + W L E S S L+ R K V L + + LLA
Sbjct: 193 LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAM 252
Query: 2028 ASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLC 2087
S D ++W E+ + L H+GP+ ++ G + + G D++ +
Sbjct: 253 GSYDGFARIW----------TENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTII 302
Query: 2088 WDVRT--PKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFL 2145
WD T K HS PA DW + SCS+D + + + F
Sbjct: 303 WDAHTGEAKQQFPFHSAPALDVDWQNNMTFA------SCSTDMCIHVCRLGCDHPVKTFQ 356
Query: 2146 GHQSAVSAVAAVEEHVV--SVSRDGTLKVWD-HQGVELTSIPAHSGPISHCAAAMEPRAA 2202
GH + V+A+ ++ S S D TLK+W Q + + AHS I + A
Sbjct: 357 GHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPAT 416
Query: 2203 GQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSV 2262
P S +++ + D RLW THTL+ H PV + A S + + S D V
Sbjct: 417 SNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYV 476
Query: 2263 RLW 2265
+W
Sbjct: 477 HIW 479
Score = 73.2 bits (178), Expect = 3e-12
Identities = 82/334 (24%), Positives = 131/334 (39%), Gaps = 62/334 (18%)
Query: 2055 TELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPK----TPVLI--------HSF 2102
T LRGHE V C+++ LA+G D + W++ T +++ H
Sbjct: 173 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
Query: 2103 PACHRDWVTGCAWTKDNLLISCSS-DGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEE-- 2159
P+ ++D VT W D L++ S DG +W E+G H+ + A+ ++
Sbjct: 233 PS-NKD-VTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 2160 HVVSVSRDGTLKVWD-HQGVELTSIPAHSGP-----------ISHCAAAM---------- 2197
+V+S D T +WD H G P HS P + C+ M
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
Query: 2198 -----------EPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHS-------- 2238
E A S +L+ + D ++W H L HS
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKW 409
Query: 2239 GPVRAAAVSETSGLML-TASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVS 2297
P A + S +ML +AS D +VRLW V + + + V +VA++PDG S
Sbjct: 410 SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLAS 469
Query: 2298 GNQAGELILW--QEAKAVATAQAPGHIGALIWSS 2329
G+ + +W Q V + Q G I + W++
Sbjct: 470 GSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNA 503
Score = 64.3 bits (155), Expect = 2e-09
Identities = 77/301 (25%), Positives = 128/301 (42%), Gaps = 28/301 (9%)
Query: 1845 IRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGE 1904
+ +L +N G ++A+G D +W G + H G + A + G +L+AG
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGV 296
Query: 1905 DGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRAD-GIRIYKISSGSQGA 1963
D +W G + S +PAL V + D I + ++
Sbjct: 297 DKTTIIWDAHTGEAKQQFPFHS-APALDV--DWQNNMTFASCSTDMCIHVCRLGCDHPVK 353
Query: 1964 QGQALDVAVSALAW-LSPKVLVSGAEDGSLQGWALK-ECSLQSLWLLSR----FQKPVLG 2017
Q V+A+ W S +L S ++D +L+ W++K + + L S+ + G
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTG 413
Query: 2018 LATSQE----LLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDG 2073
ATS +LASAS D TV+LW E C L H+ PV +FS DG
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLW---------DVEQGVCTHTLMKHQEPVYSVAFSPDG 464
Query: 2074 GSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLW 2133
LA+G D+ + W+ ++ L+HS+ + C + + + + +SDGSV +
Sbjct: 465 KYLASGSFDKYVHIWNTQSGS---LVHSYQGTGGIFEV-CWNARGDKVGASASDGSVCVL 520
Query: 2134 D 2134
D
Sbjct: 521 D 521
Score = 40.4 bits (93), Expect = 0.023
Identities = 21/89 (23%), Positives = 38/89 (42%)
Query: 1736 AFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAF 1795
+FD + LWD++ G HQ + SPD + LA+ + +W+T G L
Sbjct: 429 SFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVH 488
Query: 1796 QHTYPKSLNCVAFHPEGQVIATGSWAGSI 1824
+ + V ++ G + + GS+
Sbjct: 489 SYQGTGGIFEVCWNARGDKVGASASDGSV 517
Score = 37.4 bits (85), Expect = 0.20
Identities = 63/318 (19%), Positives = 117/318 (36%), Gaps = 44/318 (13%)
Query: 1756 KAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRG------QLAFQHTYP--------- 1800
+ H+ ++ C +P LLA+ ++W+ QL +H
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235
Query: 1801 KSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVG 1860
K + + ++ +G ++A GS+ G + +G + LG I L +N G V
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIWTENG-NLASTLGQHKGPIFALKWNKKGNYVLSA 294
Query: 1861 RLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRP-- 1918
+D +W G FP H A + + D + V P
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFP-FHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVK 353
Query: 1919 --RGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALA 1976
+GH ++ ++ P G +A ++I+ + + QA + +
Sbjct: 354 TFQGHTNEVN-----AIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIK 408
Query: 1977 WL----------SPKVLVSGAEDGSLQGWALKE--CSLQSLWLLSRFQKPVLGLATSQE- 2023
W S +L S + D +++ W +++ C+ L + Q+PV +A S +
Sbjct: 409 WSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCT----HTLMKHQEPVYSVAFSPDG 464
Query: 2024 -LLASASEDFTVQLWPRQ 2040
LAS S D V +W Q
Sbjct: 465 KYLASGSFDKYVHIWNTQ 482
Score = 32.7 bits (73), Expect = 4.8
Identities = 35/179 (19%), Positives = 69/179 (38%), Gaps = 17/179 (9%)
Query: 1748 HGCR------VLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQ-HTYP 1800
H CR V + H ++ P LLA+ LK+W + +
Sbjct: 342 HVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHS 401
Query: 1801 KSLNCVAFHPEGQ---------VIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFN 1851
K + + + P G ++A+ S+ ++ + V+ T L + ++AF+
Sbjct: 402 KEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFS 461
Query: 1852 VPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQV 1910
G +A G D V +W + G+ + ++ G + + G ++ + DG V V
Sbjct: 462 PDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGG-IFEVCWNARGDKVGASASDGSVCV 519
>gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo
sapiens]
Length = 475
Score = 81.6 bits (200), Expect = 9e-15
Identities = 83/305 (27%), Positives = 133/305 (43%), Gaps = 34/305 (11%)
Query: 2027 SASEDFTVQLWPRQLLTRPHKAEDFPCGTELR--GHEGPVSCCSFSTDGGSLATGGRDRS 2084
SA++D ++ W + + H G E + GH V C + S+DG LA+G R +
Sbjct: 163 SAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKL 222
Query: 2085 LLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTK-DNLLISCSSDGSVGLWDPESGQRLGQ 2143
+L W+ ++ + +++F HRD V+G A+ + + L S S D SV +W+ +
Sbjct: 223 ILIWEAQSCQH---LYTFTG-HRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVET 278
Query: 2144 FLGHQSAVSAVAAVEEH--VVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRA 2201
GHQ AV+A+ A+ V + RDGT++VW H G I C +
Sbjct: 279 LFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSID-CIHLI---- 333
Query: 2202 AGQPGSELLVVTVGLDGATRLW-----HPL-LVCQTHTLLGHSGP-----VRAAAVSETS 2250
+E +V+ DG+ LW PL L + H L G G + + A +
Sbjct: 334 -----NEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNT 388
Query: 2251 GLMLTASEDGSVRLWQVP---KEADDTCIPRSSAAVTAVAWAPDGSMAVSG-NQAGELIL 2306
L+ T S VRLWQ ++ D C + ++ ++ G V+G Q L
Sbjct: 389 DLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAGVGQEHRLGR 448
Query: 2307 WQEAK 2311
W K
Sbjct: 449 WWRIK 453
Score = 65.9 bits (159), Expect = 5e-10
Identities = 72/321 (22%), Positives = 132/321 (41%), Gaps = 45/321 (14%)
Query: 2057 LRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRT-------PKTPVLIHSFPACHRDW 2109
LRGH+ ++C + D ++ + +D S++ W V + P+ P H
Sbjct: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201
Query: 2110 VTGCAWTKDNLLISCSSDGS--VGLWDPESGQRLGQFLGHQSAVSAVA--AVEEHVVSVS 2165
V A + D ++ S D S + +W+ +S Q L F GH+ AVS +A + S S
Sbjct: 202 VLCMAISSDGKYLA-SGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTS 260
Query: 2166 RDGTLKVWD-HQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWH 2224
D ++KVW+ + + ++ H ++ A E V G DG R+W
Sbjct: 261 HDRSVKVWNVAENSYVETLFGHQDAVA---------ALDALSRECCVTAGGRDGTVRVWK 311
Query: 2225 PLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAA-- 2282
Q GH G + + M++ ++DGSV LW + K+ + R +
Sbjct: 312 IPEESQL-VFYGHQGSIDCIHLINEEH-MVSGADDGSVALWGLSKKR-PLALQREAHGLR 368
Query: 2283 ----------VTAVAWAPDGSMAVSGNQAGELILWQ------EAKAVATAQAPGHIGALI 2326
+++VA + + +G+ + + LWQ + + G I +L
Sbjct: 369 GEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLK 428
Query: 2327 WSSAHTFFV--LSADEKISEW 2345
+SS+ F V + + ++ W
Sbjct: 429 FSSSGDFLVAGVGQEHRLGRW 449
Score = 44.3 bits (103), Expect = 0.002
Identities = 80/362 (22%), Positives = 139/362 (38%), Gaps = 36/362 (9%)
Query: 1700 VYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLLELWDLQHGC----RVLQT 1755
+YL LR +EEK+ + L +D L L ++Q RVL
Sbjct: 85 LYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVL-- 142
Query: 1756 KAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLN----------- 1804
+ HQ IT ++PD + + + W G+ H P++
Sbjct: 143 RGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKL--HVIPRAKKGAEGKPPGHSS 200
Query: 1805 ---CVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGR 1861
C+A +G+ +A+G + I ++ + ++ LAF +
Sbjct: 201 HVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTS 260
Query: 1862 LDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVW---SGSLGRP 1918
D V++W E + + H VAA L C + G DG V+VW S
Sbjct: 261 HDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVF 320
Query: 1919 RGHLGSLS----LSPALSVALSPDGDRVAVGY-RADGIRIYKISSGSQGAQGQALDVAVS 1973
GH GS+ ++ V+ + DG G + + + + + G +G G +S
Sbjct: 321 YGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWIS 380
Query: 1974 AL-AWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDF 2032
++ A L+ ++ +G+ ++ W E + L LL P++G S L S+S DF
Sbjct: 381 SVAALLNTDLVATGSHSSCVRLWQCGE-GFRQLDLLCDI--PLVGFINS--LKFSSSGDF 435
Query: 2033 TV 2034
V
Sbjct: 436 LV 437
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 80.9 bits (198), Expect = 2e-14
Identities = 76/275 (27%), Positives = 116/275 (42%), Gaps = 8/275 (2%)
Query: 1683 AFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTA-FDGLL 1741
AFS +GQ G+ +G VY + R+ Q + + C F D LF +A D +
Sbjct: 28 AFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTV 87
Query: 1742 ELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ-LAFQHTYP 1800
LWD+ + K HQ + SPD R LA+ + LWD GQ L +
Sbjct: 88 RLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHR 147
Query: 1801 KSLNCVAFHPEGQVIATGSWAGSISFF---QVDGLKVTKDLGAPGASIRTLAFNVPGGVV 1857
S+ F P +ATGSW ++ + V + L A+I L ++ G++
Sbjct: 148 DSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA-SGLL 206
Query: 1858 AVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGR 1917
A G D + +W + L H +V + F L +AG V+VW + G+
Sbjct: 207 ASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGK 266
Query: 1918 PRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIR 1952
L + L A + A +PDG ++ V AD R
Sbjct: 267 CLETLKGV-LDVAHTCAFTPDG-KILVSGAADQTR 299
Score = 75.9 bits (185), Expect = 5e-13
Identities = 70/279 (25%), Positives = 126/279 (45%), Gaps = 16/279 (5%)
Query: 1721 ISACLFLSDDTLFLTAF-DGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCL 1779
+++ F D + LT DG + W+ + G + + H + C SPD L A+
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASC 83
Query: 1780 GGCLKLWDTVRGQ-LAFQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDL 1838
++LWD R + L + +S+ V+F P+ + +A+G W + + V ++ + L
Sbjct: 84 DCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLL 143
Query: 1839 GAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVA-AALFLHAGC 1897
SI++ F+ +A G DS V +W R + A G A + ++
Sbjct: 144 VGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSAS 203
Query: 1898 QLLTAGE-DGKVQVW----SGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIR 1952
LL +G D + +W S L + +GH+ + S+A SPD +A + ++
Sbjct: 204 GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVK-----SIAFSPDELWLASAGYSRMVK 258
Query: 1953 IYKISSGS--QGAQGQALDVAVSALAWLSPKVLVSGAED 1989
++ ++G + +G LDVA + K+LVSGA D
Sbjct: 259 VWDCNTGKCLETLKG-VLDVAHTCAFTPDGKILVSGAAD 296
Score = 73.6 bits (179), Expect = 2e-12
Identities = 64/239 (26%), Positives = 97/239 (40%), Gaps = 56/239 (23%)
Query: 1981 KVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQE--LLASASEDFTVQLWP 2038
++L++G+EDG + GW + S Q LW L PV S + L ASAS D TV+LW
Sbjct: 34 QMLLTGSEDGCVYGWETR--SGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Query: 2039 RQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPK---- 2094
C L+GH+ V SFS D LA+GG D+ ++ WDV++ +
Sbjct: 92 ---------VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRL 142
Query: 2095 -------------------------------------TPVLIHSFPACHRDWVTGCAWTK 2117
TP + H H ++ ++
Sbjct: 143 LVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA 202
Query: 2118 DNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEH--VVSVSRDGTLKVWD 2174
LL S S D ++ +W P + L Q GH + V ++A + + S +KVWD
Sbjct: 203 SGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261
Score = 70.9 bits (172), Expect = 2e-11
Identities = 76/298 (25%), Positives = 116/298 (38%), Gaps = 26/298 (8%)
Query: 1876 RLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVAL 1935
R+ F H G V ++ F G LLT EDG V W G+ LG P
Sbjct: 13 RVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGG-HTGPVKFCRF 71
Query: 1936 SPDGDRVAVGYRADGIRIYKISSGS-----QGAQGQALDVAVSALAWLSPKVLVSGAEDG 1990
SPDG A +R++ ++ +G Q V+ S + L SG D
Sbjct: 72 SPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSP----DSRQLASGGWDK 127
Query: 1991 SLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTR--PHKA 2048
+ W ++ + L + R + + LA+ S D TV +W +++T H+A
Sbjct: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187
Query: 2049 EDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRD 2108
L GH +SC +S G LA+G D+++ W T + + H
Sbjct: 188 --------LEGHSANISCLCYSA-SGLLASGSWDKTIHIWKPTTSSLLIQLKG----HVT 234
Query: 2109 WVTGCAWTKDNL-LISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVS 2165
WV A++ D L L S V +WD +G+ L G A + + VS
Sbjct: 235 WVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVS 292
Score = 66.2 bits (160), Expect = 4e-10
Identities = 69/295 (23%), Positives = 113/295 (38%), Gaps = 33/295 (11%)
Query: 1803 LNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRL 1862
+N AF P+GQ++ TGS G + ++ ++ LG ++ F+ G + A
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASC 83
Query: 1863 DSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPR--- 1919
D V LW L H V F QL + G D +V +W G+
Sbjct: 84 DCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLL 143
Query: 1920 -GHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALD---VAVSAL 1975
GH S+ S SP + +A G + I+ + + QAL+ +S L
Sbjct: 144 VGHRDSIQSSD-----FSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
Query: 1976 AWLSPKVLVSGAEDGSLQGWALKECSL------QSLWLLSRFQKPVLGLATSQELLASAS 2029
+ + +L SG+ D ++ W SL W+ S + + + LASA
Sbjct: 199 CYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKS------IAFSPDELWLASAG 252
Query: 2030 EDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRS 2084
V++W C L+G C+F+ DG L +G D++
Sbjct: 253 YSRMVKVW---------DCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Score = 57.8 bits (138), Expect = 1e-07
Identities = 68/296 (22%), Positives = 117/296 (39%), Gaps = 29/296 (9%)
Query: 2106 HRDWVTGCAWTKDN-LLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVA-AVEEHV-V 2162
H V A++ D +L++ S DG V W+ SGQ L + GH V + + H+
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 2163 SVSRDGTLKVWDHQGVE-LTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATR 2221
S S D T+++WD + L + H + + + + R + + G D
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ---------LASGGWDKRVM 130
Query: 2222 LWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLW---QVPKEADDTCIPR 2278
LW L+GH ++++ S T + T S D +V +W V +
Sbjct: 131 LWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEG 190
Query: 2279 SSAAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHIGALIWSSAHTFFVLSA 2338
SA ++ + ++ G +A SG+ + +W+ + Q GH+ W + F S
Sbjct: 191 HSANISCLCYSASGLLA-SGSWDKTIHIWKPTTSSLLIQLKGHV---TWVKSIAF---SP 243
Query: 2339 DEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLT---SLDWAPDGHFLILAKAD 2391
DE W + + L+ GVL + + PDG L+ AD
Sbjct: 244 DEL---WLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 80.9 bits (198), Expect = 2e-14
Identities = 74/283 (26%), Positives = 118/283 (41%), Gaps = 21/283 (7%)
Query: 2057 LRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWT 2116
L GH VS FS +G LA+ DR ++ W K ++ H ++ AW+
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYG----HNLEISDVAWS 92
Query: 2117 KD-NLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSA--VAAVEEHVVSVSRDGTLKVW 2173
D + L+S S D ++ LWD SG+ L GH + V ++S S D T+K+W
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 2174 D-HQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTH 2232
+ G L ++ AHS P+S A+ +G L+V+ DG R+W
Sbjct: 153 EVKTGKCLKTLSAHSDPVS----AVHFNCSGS-----LIVSGSYDGLCRIWDAASGQCLK 203
Query: 2233 TLLGHSG-PVRAAAVSETSGLMLTASEDGSVRLWQVPKE---ADDTCIPRSSAAVTAVAW 2288
TL+ PV S +LTA+ D +++LW + T + A
Sbjct: 204 TLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFS 263
Query: 2289 APDGSMAVSGNQAGELILWQEAKAVATAQAPGHIGALIWSSAH 2331
G VSG++ + +W + GH +I ++ H
Sbjct: 264 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACH 306
Score = 75.1 bits (183), Expect = 9e-13
Identities = 66/248 (26%), Positives = 113/248 (45%), Gaps = 26/248 (10%)
Query: 2025 LASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRS 2084
L SAS+D T++LW C L+GH V CC+F+ + +G D +
Sbjct: 98 LVSASDDKTLKLWD---------VRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDET 148
Query: 2085 LLCWDVRTPKTPVLIHSFPACHRDWVTGCAWT-KDNLLISCSSDGSVGLWDPESGQRLGQ 2143
+ W+V+T K + + H D V+ + +L++S S DG +WD SGQ L
Sbjct: 149 VKIWEVKTGKCLKTL----SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKT 204
Query: 2144 FLGHQS-AVSAV--AAVEEHVVSVSRDGTLKVWDH-QGVELTSIPAHSGPISHCAAAMEP 2199
+ + VS V + +++++ + D TLK+WD+ +G L + H +C A
Sbjct: 205 LVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNE-KYCIFANFS 263
Query: 2200 RAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTAS-- 2257
G+ +V+ D +W+ L GH+ V +AA T L+ +A+
Sbjct: 264 VTGGK-----WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALE 318
Query: 2258 EDGSVRLW 2265
D +++LW
Sbjct: 319 NDKTIKLW 326
Score = 67.8 bits (164), Expect = 1e-10
Identities = 56/241 (23%), Positives = 105/241 (43%), Gaps = 10/241 (4%)
Query: 1680 TAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDG 1739
++V FS NG+ A +A+ + + + EK++ IS + SD + ++A D
Sbjct: 45 SSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDD 104
Query: 1740 -LLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ-LAFQH 1797
L+LWD++ G + K H + C +P L+ + +K+W+ G+ L
Sbjct: 105 KTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLS 164
Query: 1798 TYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDG---LKVTKDLGAPGASIRTLAFNVPG 1854
+ ++ V F+ G +I +GS+ G + LK D P S + F+ G
Sbjct: 165 AHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSF--VKFSPNG 222
Query: 1855 GVVAVGRLDSMVELWAWREGARLAAFPAHHG---FVAAALFLHAGCQLLTAGEDGKVQVW 1911
+ LD+ ++LW + G L + H + A + G +++ ED V +W
Sbjct: 223 KYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 282
Query: 1912 S 1912
+
Sbjct: 283 N 283
Score = 67.8 bits (164), Expect = 1e-10
Identities = 68/253 (26%), Positives = 107/253 (42%), Gaps = 30/253 (11%)
Query: 2023 ELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRD 2082
E LAS+S D + +W A D L GH +S ++S+D L + D
Sbjct: 54 EWLASSSADRLIIIWG---------AYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDD 104
Query: 2083 RSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWT-KDNLLISCSSDGSVGLWDPESGQRL 2141
++L WDVR+ K + H ++V C + NL+IS S D +V +W+ ++G+ L
Sbjct: 105 KTLKLWDVRSGKCLKTLKG----HSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCL 160
Query: 2142 GQFLGHQSAVSAV--AAVEEHVVSVSRDGTLKVWDHQGVEL--TSIPAHSGPISHCAAAM 2197
H VSAV +VS S DG ++WD + T + + P+S +
Sbjct: 161 KTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSP 220
Query: 2198 EPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRA--AAVSETSG-LML 2254
+ ++T LD +LW T GH A S T G ++
Sbjct: 221 NGK---------YILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIV 271
Query: 2255 TASEDGSVRLWQV 2267
+ SED V +W +
Sbjct: 272 SGSEDNLVYIWNL 284
Score = 58.9 bits (141), Expect = 6e-08
Identities = 61/290 (21%), Positives = 120/290 (41%), Gaps = 13/290 (4%)
Query: 1758 HQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQ-HTYPKSLNCVAFHPEGQVIA 1816
H ++ SP+ LA+ + +W G+ + + ++ VA+ + +
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99
Query: 1817 TGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGAR 1876
+ S ++ + V K K L + FN P ++ G D V++W + G
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159
Query: 1877 LAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALS 1936
L AH V+A F +G +++ DG ++W + G+ L P V S
Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFS 219
Query: 1937 PDGDRVAVGYRADGIRIYKISSGS-----QGAQGQALDVAVSALAWLSPKVLVSGAEDGS 1991
P+G + + ++++ S G G + + + + + K +VSG+ED
Sbjct: 220 PNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFAN-FSVTGGKWIVSGSEDNL 278
Query: 1992 LQGWALKECSLQSLWLLSRFQKPVLGLA--TSQELLASAS--EDFTVQLW 2037
+ W L+ + + + L V+ A ++ L+ASA+ D T++LW
Sbjct: 279 VYIWNLQ--TKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 39.7 bits (91), Expect = 0.040
Identities = 28/123 (22%), Positives = 49/123 (39%), Gaps = 4/123 (3%)
Query: 2233 TLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDG 2292
TL+GH+ V + S + ++S D + +W + + + ++ VAW+ D
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 2293 SMAVSGNQAGELILWQEAKAVATAQAPGHIGALIWSS----AHTFFVLSADEKISEWQVK 2348
S VS + L LW GH + + ++ S DE + W+VK
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
Query: 2349 LRK 2351
K
Sbjct: 156 TGK 158
Score = 33.5 bits (75), Expect = 2.8
Identities = 30/118 (25%), Positives = 52/118 (44%), Gaps = 6/118 (5%)
Query: 2252 LMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQEAK 2311
L L++S + S + + P A + + AV++V ++P+G S + +I+W
Sbjct: 13 LALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYD 72
Query: 2312 AVATAQAPGH---IGALIWSSAHTFFVLSADEK-ISEWQVKLRKGSAPGNLSLHLNRI 2365
GH I + WSS + V ++D+K + W V R G L H N +
Sbjct: 73 GKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDV--RSGKCLKTLKGHSNYV 128
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 80.5 bits (197), Expect = 2e-14
Identities = 73/329 (22%), Positives = 133/329 (40%), Gaps = 44/329 (13%)
Query: 1982 VLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQL 2041
V+VS +ED +++ W + + + S +LLAS S D T++LW Q
Sbjct: 122 VMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ- 180
Query: 2042 LTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHS 2101
F C + GH+ VS + +G + + RD+++ W+V +T + +
Sbjct: 181 --------GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV---QTGYCVKT 229
Query: 2102 FPACHRDWVTGCAWTKDNLLI-SCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVA-AVEE 2159
F HR+WV +D LI SCS+D +V +W + + + H+ V ++ A E
Sbjct: 230 FTG-HREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPES 288
Query: 2160 HVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGA 2219
S+S A E + +G+PG LL + D
Sbjct: 289 SYSSISE---------------------------ATGSETKKSGKPGPFLL--SGSRDKT 319
Query: 2220 TRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRS 2279
++W TL+GH VR +L+ ++D ++R+W + +
Sbjct: 320 IKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAH 379
Query: 2280 SAAVTAVAWAPDGSMAVSGNQAGELILWQ 2308
VT++ + V+G+ + +W+
Sbjct: 380 EHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 73.9 bits (180), Expect = 2e-12
Identities = 91/424 (21%), Positives = 154/424 (36%), Gaps = 107/424 (25%)
Query: 2002 LQSLWL-LSRFQKPVLGLATSQELLASASEDFTV------QLWPRQLLTRPHKAEDFPCG 2054
L+ W + R QK V+ L + L A E+FT + P++ + RP P
Sbjct: 51 LEKKWTSVIRLQKKVMELESK---LNEAKEEFTSGGPLGQKRDPKEWIPRP------PEK 101
Query: 2055 TELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCA 2114
L GH PV+ F + + D ++ WD T + H D V +
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKG----HTDSVQDIS 157
Query: 2115 WT-KDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVE--EHVVSVSRDGTLK 2171
+ LL SCS+D ++ LWD + + + GH VS+VA + +H+VS SRD T+K
Sbjct: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIK 217
Query: 2172 VWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQT 2231
+W+ Q +C
Sbjct: 218 MWEVQ-------------TGYC-------------------------------------V 227
Query: 2232 HTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPD 2291
T GH VR ++ L+ + S D +VR+W V + + V ++WAP+
Sbjct: 228 KTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPE 287
Query: 2292 --------------------GSMAVSGNQAGELILWQEAKAVATAQAPGH---IGALIWS 2328
G +SG++ + +W + + GH + +++
Sbjct: 288 SSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFH 347
Query: 2329 SAHTFFVLSADEK-ISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAPDGHFLIL 2387
S F + AD+K + W K ++ N H +TSLD+ +++
Sbjct: 348 SGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHF----------VTSLDFHKTAPYVVT 397
Query: 2388 AKAD 2391
D
Sbjct: 398 GSVD 401
Score = 63.5 bits (153), Expect = 3e-09
Identities = 73/327 (22%), Positives = 134/327 (40%), Gaps = 52/327 (15%)
Query: 1879 AFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLG----RPRGHLGS---LSLSPAL 1931
A H V +F +++A ED ++VW G +GH S +S +
Sbjct: 103 ALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSG 162
Query: 1932 SVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWL-SPKVLVSGAEDG 1990
+ S D + G + G D VS++A + + +VS + D
Sbjct: 163 KLLASCSADMTIKLWDFQGFECIRTMHGH--------DHNVSSVAIMPNGDHIVSASRDK 214
Query: 1991 SLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAED 2050
+++ W ++ + R ++ L+AS S D TV++W + T+
Sbjct: 215 TIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW--VVATK------ 266
Query: 2051 FPCGTELRGHEGPVSCCSFSTD--------------------GGSLATGGRDRSLLCWDV 2090
C ELR HE V C S++ + G L +G RD+++ WDV
Sbjct: 267 -ECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV 325
Query: 2091 RTPKTPVLIHSFPACHRDWVTGCAW-TKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQS 2149
T + + H +WV G + + ++SC+ D ++ +WD ++ + + H+
Sbjct: 326 STGMCLMTL----VGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEH 381
Query: 2150 AVSAV--AAVEEHVVSVSRDGTLKVWD 2174
V+++ +VV+ S D T+KVW+
Sbjct: 382 FVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 47.4 bits (111), Expect = 2e-04
Identities = 56/312 (17%), Positives = 123/312 (39%), Gaps = 41/312 (13%)
Query: 1806 VAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSM 1865
V FHP V+ + S +I + + + L S++ ++F+ G ++A D
Sbjct: 114 VIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMT 173
Query: 1866 VELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRP----RGH 1921
++LW ++ + H V++ + G +++A D +++W G GH
Sbjct: 174 IKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGH 233
Query: 1922 LGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPK 1981
+ + V + DG +A +R++ +++ A+ + + V ++W
Sbjct: 234 REWVRM-----VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPES 288
Query: 1982 ---------------------VLVSGAEDGSLQGWALKE-CSLQSLWLLSRFQKPVLGLA 2019
L+SG+ D +++ W + L +L + + VL
Sbjct: 289 SYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVL-FH 347
Query: 2020 TSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATG 2079
+ + + S ++D T+++W + + C L HE V+ F + TG
Sbjct: 348 SGGKFILSCADDKTLRVWDYK---------NKRCMKTLNAHEHFVTSLDFHKTAPYVVTG 398
Query: 2080 GRDRSLLCWDVR 2091
D+++ W+ R
Sbjct: 399 SVDQTVKVWECR 410
Score = 46.2 bits (108), Expect = 4e-04
Identities = 43/232 (18%), Positives = 94/232 (40%), Gaps = 24/232 (10%)
Query: 1682 VAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSD-DTLFLTAFDGL 1740
++F +G+ A +A+ T+ L D + ++ +++ +S+ + + D + + D
Sbjct: 156 ISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKT 215
Query: 1741 LELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQ-HTY 1799
+++W++Q G V H+ + + D L+A+ +++W + + +
Sbjct: 216 IKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREH 275
Query: 1800 PKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAV 1859
+ C+++ PE + GS TK G PG + +
Sbjct: 276 EHVVECISWAPESSYSSISEATGS----------ETKKSGKPGPFLLS------------ 313
Query: 1860 GRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVW 1911
G D +++W G L H +V LF G +L+ +D ++VW
Sbjct: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Score = 39.3 bits (90), Expect = 0.052
Identities = 30/133 (22%), Positives = 53/133 (39%), Gaps = 1/133 (0%)
Query: 1738 DGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ-LAFQ 1796
D +++WD + G K H + +LLA+ +KLWD + +
Sbjct: 129 DATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTM 188
Query: 1797 HTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGV 1856
H + +++ VA P G I + S +I ++V K +R + N G +
Sbjct: 189 HGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTL 248
Query: 1857 VAVGRLDSMVELW 1869
+A D V +W
Sbjct: 249 IASCSNDQTVRVW 261
>gi|89886480 zinedin isoform 2 [Homo sapiens]
Length = 760
Score = 78.2 bits (191), Expect = 1e-13
Identities = 79/304 (25%), Positives = 125/304 (41%), Gaps = 37/304 (12%)
Query: 2021 SQELLASASEDFTVQLWPRQ--LLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLAT 2078
SQ L +ASED T++LW Q + + + A D R H GPV + ++ +
Sbjct: 456 SQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYS 515
Query: 2079 GGRDRSLLCW-------DVRTPKTPVLIHSFPACHRDWVTGCAWTKDNL-LISCSSDGSV 2130
GG D + W D P ++ H D V G A++ + L SCS+DG+V
Sbjct: 516 GGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTV 575
Query: 2131 GLWDPESGQRL-------GQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQ-GVELTS 2182
+WDP S G ++V+ + H+V+ R G ++D + G L +
Sbjct: 576 RIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLT 635
Query: 2183 IPAH--SGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGP 2240
+ + SGP P QP L +T D R H+++ H
Sbjct: 636 LESRGSSGPTQINQVVSHPN---QP----LTITAHDDRGIRFLDNRTGKPVHSMVAHLDA 688
Query: 2241 VRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSA-------AVTAVAWAPDGS 2293
V AV +++ S D S+RLW + + TC+ +A A+ AVA P +
Sbjct: 689 VTCLAVDPNGAFLMSGSHDCSLRLWSLDNK---TCVQEITAHRKKHEEAIHAVACHPSKA 745
Query: 2294 MAVS 2297
+ S
Sbjct: 746 LIAS 749
Score = 48.9 bits (115), Expect = 7e-05
Identities = 70/312 (22%), Positives = 129/312 (41%), Gaps = 49/312 (15%)
Query: 2116 TKDNLL---ISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAA--VEEHVVSVSRDGTL 2170
T DN L +S S D W+P+ R H + ++A + +++ S DGTL
Sbjct: 415 TNDNDLSCDLSDSKDAFKKTWNPKFTLR-----SHYDGIRSLAFHHSQSALLTASEDGTL 469
Query: 2171 KVWDHQGV------------ELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDG 2218
K+W+ Q + + AH GP+ A G++ + + +
Sbjct: 470 KLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPD 529
Query: 2219 ATRL----WHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDT 2274
+ + P ++ +H L GH V A S TS + + S DG+VR+W P +
Sbjct: 530 LSMDPYDGYDPSVL--SHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD-PSSSSPA 586
Query: 2275 CI---PRSS--AAVTAVAW-APDGSMAVSGNQAGELILW--QEAKAVATAQAPGHIGAL- 2325
C+ P +S T+VA+ + + + V+ ++G+ +L+ + A+ T ++ G G
Sbjct: 587 CLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQ 646
Query: 2326 ---IWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAPDG 2382
+ S + ++A + + R G ++ HL+ + T L P+G
Sbjct: 647 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAV--------TCLAVDPNG 698
Query: 2383 HFLILAKADLKL 2394
FL+ D L
Sbjct: 699 AFLMSGSHDCSL 710
Score = 46.2 bits (108), Expect = 4e-04
Identities = 64/306 (20%), Positives = 115/306 (37%), Gaps = 49/306 (16%)
Query: 1882 AHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDR 1941
+H+ + + F H+ LLTA EDG +++W+ +L + P +
Sbjct: 443 SHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHA--------- 493
Query: 1942 VAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECS 2001
+RA +G L VA+ + + + SG D + W + + S
Sbjct: 494 ----FRAH--------------RGPVLAVAMGS----NSEYCYSGGADACIHSWKIPDLS 531
Query: 2002 LQSL---------WLLSRFQKPVLGLATS--QELLASASEDFTVQLWPRQLLTRPHKAED 2050
+ +L V GLA S + LAS S D TV++W + P
Sbjct: 532 MDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPS-SSSPACLCT 590
Query: 2051 FPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWV 2110
FP +E H P S ST+ + R + +D+ + + S + +
Sbjct: 591 FPTASE---HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQI 647
Query: 2111 TG-CAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEE--HVVSVSRD 2167
+ L I+ D + D +G+ + + H AV+ +A ++S S D
Sbjct: 648 NQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHD 707
Query: 2168 GTLKVW 2173
+L++W
Sbjct: 708 CSLRLW 713
>gi|89886477 zinedin isoform 1 [Homo sapiens]
Length = 753
Score = 78.2 bits (191), Expect = 1e-13
Identities = 79/304 (25%), Positives = 125/304 (41%), Gaps = 37/304 (12%)
Query: 2021 SQELLASASEDFTVQLWPRQ--LLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLAT 2078
SQ L +ASED T++LW Q + + + A D R H GPV + ++ +
Sbjct: 449 SQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYS 508
Query: 2079 GGRDRSLLCW-------DVRTPKTPVLIHSFPACHRDWVTGCAWTKDNL-LISCSSDGSV 2130
GG D + W D P ++ H D V G A++ + L SCS+DG+V
Sbjct: 509 GGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTV 568
Query: 2131 GLWDPESGQRL-------GQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQ-GVELTS 2182
+WDP S G ++V+ + H+V+ R G ++D + G L +
Sbjct: 569 RIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLT 628
Query: 2183 IPAH--SGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGP 2240
+ + SGP P QP L +T D R H+++ H
Sbjct: 629 LESRGSSGPTQINQVVSHPN---QP----LTITAHDDRGIRFLDNRTGKPVHSMVAHLDA 681
Query: 2241 VRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSA-------AVTAVAWAPDGS 2293
V AV +++ S D S+RLW + + TC+ +A A+ AVA P +
Sbjct: 682 VTCLAVDPNGAFLMSGSHDCSLRLWSLDNK---TCVQEITAHRKKHEEAIHAVACHPSKA 738
Query: 2294 MAVS 2297
+ S
Sbjct: 739 LIAS 742
Score = 48.9 bits (115), Expect = 7e-05
Identities = 70/312 (22%), Positives = 129/312 (41%), Gaps = 49/312 (15%)
Query: 2116 TKDNLL---ISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAA--VEEHVVSVSRDGTL 2170
T DN L +S S D W+P+ R H + ++A + +++ S DGTL
Sbjct: 408 TNDNDLSCDLSDSKDAFKKTWNPKFTLR-----SHYDGIRSLAFHHSQSALLTASEDGTL 462
Query: 2171 KVWDHQGV------------ELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDG 2218
K+W+ Q + + AH GP+ A G++ + + +
Sbjct: 463 KLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPD 522
Query: 2219 ATRL----WHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDT 2274
+ + P ++ +H L GH V A S TS + + S DG+VR+W P +
Sbjct: 523 LSMDPYDGYDPSVL--SHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD-PSSSSPA 579
Query: 2275 CI---PRSS--AAVTAVAW-APDGSMAVSGNQAGELILW--QEAKAVATAQAPGHIGAL- 2325
C+ P +S T+VA+ + + + V+ ++G+ +L+ + A+ T ++ G G
Sbjct: 580 CLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQ 639
Query: 2326 ---IWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAPDG 2382
+ S + ++A + + R G ++ HL+ + T L P+G
Sbjct: 640 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAV--------TCLAVDPNG 691
Query: 2383 HFLILAKADLKL 2394
FL+ D L
Sbjct: 692 AFLMSGSHDCSL 703
Score = 46.2 bits (108), Expect = 4e-04
Identities = 64/306 (20%), Positives = 115/306 (37%), Gaps = 49/306 (16%)
Query: 1882 AHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDR 1941
+H+ + + F H+ LLTA EDG +++W+ +L + P +
Sbjct: 436 SHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHA--------- 486
Query: 1942 VAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECS 2001
+RA +G L VA+ + + + SG D + W + + S
Sbjct: 487 ----FRAH--------------RGPVLAVAMGS----NSEYCYSGGADACIHSWKIPDLS 524
Query: 2002 LQSL---------WLLSRFQKPVLGLATS--QELLASASEDFTVQLWPRQLLTRPHKAED 2050
+ +L V GLA S + LAS S D TV++W + P
Sbjct: 525 MDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPS-SSSPACLCT 583
Query: 2051 FPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWV 2110
FP +E H P S ST+ + R + +D+ + + S + +
Sbjct: 584 FPTASE---HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQI 640
Query: 2111 TG-CAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEE--HVVSVSRD 2167
+ L I+ D + D +G+ + + H AV+ +A ++S S D
Sbjct: 641 NQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHD 700
Query: 2168 GTLKVW 2173
+L++W
Sbjct: 701 CSLRLW 706
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 107,708,663
Number of Sequences: 37866
Number of extensions: 5127784
Number of successful extensions: 18968
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 176
Number of HSP's successfully gapped in prelim test: 162
Number of HSP's that attempted gapping in prelim test: 14467
Number of HSP's gapped (non-prelim): 2792
length of query: 2627
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2508
effective length of database: 13,741,464
effective search space: 34463591712
effective search space used: 34463591712
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.