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Search of human proteins with 21493024
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
sapiens]
(1684 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa... 3268 0.0
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa... 3254 0.0
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 122 2e-27
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 105 3e-22
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 101 5e-21
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 101 7e-21
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 98 6e-20
gi|110349719 titin isoform N2-A [Homo sapiens] 94 1e-18
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 89 3e-17
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 87 1e-16
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 87 1e-16
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] 87 2e-16
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 87 2e-16
gi|238624188 diffuse panbronchiolitis critical region 1 protein ... 82 3e-15
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 82 4e-15
gi|239740773 PREDICTED: similar to diffuse panbronchiolitis crit... 81 1e-14
gi|87299628 biorientation of chromosomes in cell division 1-like... 79 4e-14
gi|148806928 hypothetical protein LOC57482 [Homo sapiens] 77 1e-13
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 75 7e-13
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 74 9e-13
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 74 9e-13
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 74 2e-12
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 74 2e-12
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 74 2e-12
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 74 2e-12
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 74 2e-12
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 74 2e-12
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 74 2e-12
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 74 2e-12
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 74 2e-12
>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
sapiens]
Length = 1684
Score = 3268 bits (8473), Expect = 0.0
Identities = 1684/1684 (100%), Positives = 1684/1684 (100%)
Query: 1 MLGTITITVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEE 60
MLGTITITVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEE
Sbjct: 1 MLGTITITVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEE 60
Query: 61 LTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDP 120
LTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDP
Sbjct: 61 LTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDP 120
Query: 121 SLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPS 180
SLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPS
Sbjct: 121 SLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPS 180
Query: 181 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 240
KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE
Sbjct: 181 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 240
Query: 241 EDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAP 300
EDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAP
Sbjct: 241 EDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAP 300
Query: 301 LATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAE 360
LATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAE
Sbjct: 301 LATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAE 360
Query: 361 PAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKK 420
PAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKK
Sbjct: 361 PAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKK 420
Query: 421 LFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITC 480
LFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITC
Sbjct: 421 LFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITC 480
Query: 481 LEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKV 540
LEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKV
Sbjct: 481 LEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKV 540
Query: 541 KSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSS 600
KSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSS
Sbjct: 541 KSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSS 600
Query: 601 DEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVST 660
DEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVST
Sbjct: 601 DEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVST 660
Query: 661 WESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKR 720
WESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKR
Sbjct: 661 WESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKR 720
Query: 721 PDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAAT 780
PDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAAT
Sbjct: 721 PDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAAT 780
Query: 781 EVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLE 840
EVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLE
Sbjct: 781 EVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLE 840
Query: 841 REVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEE 900
REVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEE
Sbjct: 841 REVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEE 900
Query: 901 TTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPG 960
TTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPG
Sbjct: 901 TTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPG 960
Query: 961 TGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPE 1020
TGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPE
Sbjct: 961 TGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPE 1020
Query: 1021 SFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVA 1080
SFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVA
Sbjct: 1021 SFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVA 1080
Query: 1081 DFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSK 1140
DFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSK
Sbjct: 1081 DFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSK 1140
Query: 1141 MEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREK 1200
MEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREK
Sbjct: 1141 MEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREK 1200
Query: 1201 VTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKL 1260
VTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKL
Sbjct: 1201 VTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKL 1260
Query: 1261 EHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEAS 1320
EHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEAS
Sbjct: 1261 EHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEAS 1320
Query: 1321 FTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPD 1380
FTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPD
Sbjct: 1321 FTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPD 1380
Query: 1381 CQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENG 1440
CQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENG
Sbjct: 1381 CQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENG 1440
Query: 1441 ILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEG 1500
ILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEG
Sbjct: 1441 ILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEG 1500
Query: 1501 EEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEE 1560
EEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEE
Sbjct: 1501 EEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEE 1560
Query: 1561 VVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTD 1620
VVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTD
Sbjct: 1561 VVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTD 1620
Query: 1621 ASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1680
ASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSE
Sbjct: 1621 ASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1680
Query: 1681 LTES 1684
LTES
Sbjct: 1681 LTES 1684
>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
sapiens]
Length = 1782
Score = 3254 bits (8437), Expect = 0.0
Identities = 1677/1680 (99%), Positives = 1677/1680 (99%)
Query: 5 ITITVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQP 64
I VGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQP
Sbjct: 103 IVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQP 162
Query: 65 TESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGA 124
TESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGA
Sbjct: 163 TESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGA 222
Query: 125 GEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAE 184
GEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAE
Sbjct: 223 GEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAE 282
Query: 185 SPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGK 244
SPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGK
Sbjct: 283 SPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGK 342
Query: 245 AEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATE 304
AEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATE
Sbjct: 343 AEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATE 402
Query: 305 VFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKE 364
VFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKE
Sbjct: 403 VFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKE 462
Query: 365 LVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTS 424
LVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTS
Sbjct: 463 LVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTS 522
Query: 425 TGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKG 484
TGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKG
Sbjct: 523 TGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKG 582
Query: 485 LAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSAT 544
LAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSAT
Sbjct: 583 LAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSAT 642
Query: 545 LSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEG 604
LSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEG
Sbjct: 643 LSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEG 702
Query: 605 GPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESF 664
GPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESF
Sbjct: 703 GPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESF 762
Query: 665 KRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGK 724
KRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGK
Sbjct: 763 KRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGK 822
Query: 725 QEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK 784
QEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK
Sbjct: 823 QEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK 882
Query: 785 ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVI 844
ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVI
Sbjct: 883 ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVI 942
Query: 845 AEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEM 904
AEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEM
Sbjct: 943 AEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEM 1002
Query: 905 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGP 964
VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGP
Sbjct: 1003 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGP 1062
Query: 965 EDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEK 1024
EDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEK
Sbjct: 1063 EDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEK 1122
Query: 1025 APQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDA 1084
APQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDA
Sbjct: 1123 APQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDA 1182
Query: 1085 PGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDT 1144
PGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDT
Sbjct: 1183 PGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDT 1242
Query: 1145 LEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEV 1204
LEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEV
Sbjct: 1243 LEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEV 1302
Query: 1205 ALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1264
ALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET
Sbjct: 1303 ALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1362
Query: 1265 AVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLT 1324
AVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLT
Sbjct: 1363 AVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLT 1422
Query: 1325 AAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAK 1384
AAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAK
Sbjct: 1423 AAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAK 1482
Query: 1385 STPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILEL 1444
STPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILEL
Sbjct: 1483 STPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILEL 1542
Query: 1445 ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQ 1504
ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQ
Sbjct: 1543 ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQ 1602
Query: 1505 ASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLP 1564
ASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLP
Sbjct: 1603 ASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLP 1662
Query: 1565 SEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGG 1624
SEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGG
Sbjct: 1663 SEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGG 1722
Query: 1625 LTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES 1684
LTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES
Sbjct: 1723 LTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES 1782
Score = 53.5 bits (127), Expect = 2e-06
Identities = 142/707 (20%), Positives = 245/707 (34%), Gaps = 115/707 (16%)
Query: 1047 AGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTT------------------ 1088
AG +++ EQ PP+ TP + E G P A+ AP TT
Sbjct: 3 AGSSTEQRSPEQ--PPEGSSTPAEPEPSGGGPSAE-AAPDTTADPAIAASDPATKLLQKN 59
Query: 1089 -QKDEIVEIHEENEVA-----SGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKME 1142
Q I + E++E++ Q G + +E + V Q ++++ SK +
Sbjct: 60 GQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRD 119
Query: 1143 DTLEHTDKEVSVETVS-------------ILSKTEGTQEADQYADEKTKDVPF-----FE 1184
E K V ++ I S +E Q + + D+ F F
Sbjct: 120 SDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFV 179
Query: 1185 GLEGSIDTGITVSREKVTEVALK---GEGTEEAECKKDDAL---ELQSHAKSPPSPVERE 1238
G + ++ T + V + +K GEG A KD +L E S P E+
Sbjct: 180 GFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKP 239
Query: 1239 MVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSP 1298
++RE++ AE + E E EE ++ + S E
Sbjct: 240 EET-LKREQSHAEISPPAESGQAVEECKEEGEEKQEK-------------EPSKSAESPT 285
Query: 1299 PPCLGQEEAVCTKIQVQS-----SEASFTLTAAAEEEKVLGETANILETGETLEPAGAHL 1353
P + + K Q + SF E E + E +T E A +
Sbjct: 286 SPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEV 345
Query: 1354 VLEEKSSEKNEDFAAHPGEDAVPT-----GPDCQAKSTPVIVSATTKKGLSSDLEGEKTT 1408
E+ ++ + AHP E A + + P + +G S + T
Sbjct: 346 ASEKLTASEQ----AHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLAT 401
Query: 1409 SLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVD------- 1461
+ + EV ++ EV VS E E + +E ET S + +++ +
Sbjct: 402 EVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVE-ETAGSVPAEELVEMDAEPQEAEPA 460
Query: 1462 -QFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEES 1520
+ V+ +ET ++ E TQ + D EK +P E + S++E
Sbjct: 461 KELVKLKETC---VSGEDPTQGADLSPD--------EKVLSKPPEGVVSEVEMLSSQERM 509
Query: 1521 ESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLP-----SEEEGGGAGTK 1575
+ S + + S K + G +++ E +P S+EE G +
Sbjct: 510 KVQGSPLKKLFTSTGLKKLSGKKQKGKRGGG--DEESGEHTQVPADSPDSQEEQKGESSA 567
Query: 1576 SVPEDDGHALLAERIEKSLVEPKEDEKGDD--VDDPENQNSALADTDASGGLTKESPDTN 1633
S PE+ +EK L E ++D + ++ D E + + + +
Sbjct: 568 SSPEEPEEITC---LEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVR 624
Query: 1634 GPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1680
P + +KED EL + K + S T +E K E K E
Sbjct: 625 RPSESDKED----ELDKVKSATLSSTESTASEMQEEMKGSVEEPKPE 667
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 122 bits (307), Expect = 2e-27
Identities = 255/1073 (23%), Positives = 405/1073 (37%), Gaps = 171/1073 (15%)
Query: 125 GEAASKESEPKQSTEKPEETLKREQSHAEISPPAES-GQA-----VEECKEEGEEKQEKE 178
GE +E+ + T K EE L+ E E + E GQ +EE +E G E ++E
Sbjct: 1312 GEGLQEEAVQLEET-KTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEE 1370
Query: 179 PSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVD 238
+ E P G ++ + G ++ S + E + + K QE + V
Sbjct: 1371 GVQLEEVKEGPEGGLQGEALEEGLKE--EGLPEEGSVHGQELSEASSPDGKGSQEDDPVQ 1428
Query: 239 TEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKP 298
EE G+A ++E A P EP E SA SE Q P EKP
Sbjct: 1429 EEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSA--------SERQSGSQLEPGLEKP 1480
Query: 299 APLATEVFDEKIEVHQEEVVAE---------------VHVSTVEERTEE--------QKT 335
P AT + E + + AE + VS + ++TE+
Sbjct: 1481 -PGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVA 1539
Query: 336 EVEETAGSVPAEELVEMDAEPQE--AEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSK 393
E+ G + L +M AE Q+ A+ ++ K + + G VL
Sbjct: 1540 ELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGR---------AGRMVLEP 1590
Query: 394 PPEGVVSEVEMLSSQERMKVQGSPLKKLFT--STGLKKLSGKKQK--------GKRGGGD 443
P E + E+ + + Q R +++G F+ + GL LS + G + G +
Sbjct: 1591 PREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEE 1650
Query: 444 EESGEHTQVPA-----DSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGA 498
E E A SP S + G + E + L++ E DGEA E A
Sbjct: 1651 AEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGE-HTDGEAAEVA 1709
Query: 499 T----SDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASE 554
+D R ++ V + + L++ K L E A
Sbjct: 1710 PGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDA-- 1767
Query: 555 MQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQ 614
M +E +G +TS E +G +++ S E GG
Sbjct: 1768 MAQEREGKTHNS---------ETSAGSE----LGEAEQEGEGISERGETGG--------- 1805
Query: 615 KADEAGKDKETGTDGILAGSQEHDPGQ-----GSSSPEQAG-SPTEGEGVSTWESFKRLV 668
G E G A + DPGQ G +PE G + E EGV E+
Sbjct: 1806 ----QGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEA----E 1857
Query: 669 TPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGK--EESWVSIKKFIPGRRKKRPDGKQE 726
++++ + + +SED A + P++E + E W + +P+ +
Sbjct: 1858 GDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEW-----------EVQPESEGA 1906
Query: 727 QAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKEL 786
+AP + A + V A+ E D E E EAQ+A+++A++ E + E S+ +
Sbjct: 1907 EAPEAE---KEAQPETESVEALETEGE-DEPESEGAEAQEAEEAAQEAEGQTQPE-SEVI 1961
Query: 787 SESQVHMMAAAVADGTRAATI-IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIA 845
+ A ++ A + +E + + +E +E EAE E+ E E A
Sbjct: 1962 ESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEG-----EMQEAEEEA 2016
Query: 846 EEEPPTV-TEPLPENREAR---GDTVVSEAELTPEAVTAAETAGPLGAEEGTEA-SAAEE 900
+ E V +P E EA+ G+T +E + PE+ +G EA A EE
Sbjct: 2017 QPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES-------------DGVEAPEAEEE 2063
Query: 901 TTEMVSAVSQLTDSPDTTEEATPVQEVEG-GVPDIEEQERRTQEVLQAVAEKVKEESQLP 959
E V + E QE EG P+ E E E AE + E +
Sbjct: 2064 AQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGI-EAPETE 2122
Query: 960 GTGGPED--VLQPVQRAEAERPEEQAEASGLKKETDVVLK-VDAQEAKTEPFTQGKVVGQ 1016
G PE + P EA+ E EA + E + ++AQEA+ E Q ++ G
Sbjct: 2123 GEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEE--AQPELEGV 2180
Query: 1017 TTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGS 1076
PE+ +A +E IE+ E Q E L GV++ E E P+ VETP E +G
Sbjct: 2181 EAPEAEGEAQPESEGIEAPEAEGEAQPE-LEGVEAPEAEEEAQPEPEGVETP---EAEGE 2236
Query: 1077 TPVADFDAPGTTQKDEIVEIHEENEVASGT-QSGGTEAEAVPAQKERPPAPSS 1128
A ++ G TQ ++ +V+ G QS + P ++RP P S
Sbjct: 2237 ---AQPESEGETQGEK----KGSPQVSLGDGQSEEASESSSPVPEDRPTPPPS 2282
Score = 92.8 bits (229), Expect = 2e-18
Identities = 239/1137 (21%), Positives = 407/1137 (35%), Gaps = 144/1137 (12%)
Query: 212 KTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPR 271
KTS ++P E+ + Q+ T + +A + +E+ ++ A S E +
Sbjct: 1233 KTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLE-Q 1291
Query: 272 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 331
L+ + E+ EE G++G E QEE V ++ + EE +
Sbjct: 1292 LAENTVQEEVQLEETKEGTEG------------------EGLQEEAV-QLEETKTEEGLQ 1332
Query: 332 EQKTEVEETAGSVPAEELVEMDAEPQEAEPA------KELVKLKETCVSGEDPTQGADLS 385
E+ ++EET E E +A+ +E E +E V+L+E E QG L
Sbjct: 1333 EEGVQLEETK-ETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALE 1391
Query: 386 PDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEE 445
K P EG V E LS +GS + S + G +E
Sbjct: 1392 EGLKEEGLPEEGSVHGQE-LSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEP 1450
Query: 446 SGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKK 505
+ + + P + E Q G E+P T + + + Q A E ++S
Sbjct: 1451 TEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSA 1510
Query: 506 REGVTP-WASFKKMVTPKKRVRRPSESDKE-------DELDKVKSATLSSTESTASEMQE 557
P W S T K + + + E + D + + A +Q+
Sbjct: 1511 ALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQD 1570
Query: 558 EMKGSVEEPKPE------EPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGG 611
K +++ + EP R+ T L+ ++ RG + + +G
Sbjct: 1571 STKRELQKLQGRAGRMVLEPPREALTG----ELLLQTQQRRHRLRGLRNLSAFSERTLGL 1626
Query: 612 DHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWES-FKRLVTP 670
G L+ + E +P ++ Q G EGE E+ ++ V+P
Sbjct: 1627 -----------------GPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSP 1669
Query: 671 RKK------SKSKLEEKSE-----DSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKK 719
++ ++E + G + + PGK + + + + G
Sbjct: 1670 MSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGG 1729
Query: 720 RPDGKQEQAPVEDAGPTGANED--DSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQK 777
G Q P D G G + D + +E DA+ +E+ E
Sbjct: 1730 LGPGLS-QGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQER----------EGKTHN 1778
Query: 778 AATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEE 837
+ T EL E++ +G I ER + S E Q EA A +
Sbjct: 1779 SETSAGSELGEAEQE------GEG------ISERGETGGQGSGHEDNLQGEAAAGGDQDP 1826
Query: 838 VLEREVIAEEEPPTVTEPLPENR-----EARGDTVVSEAELTPEA--VTAAETAGPLGAE 890
E P E PE+ EA GD +E E PE+ V A E G A+
Sbjct: 1827 GQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGE--AQ 1884
Query: 891 EGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAE 950
+E E V S+ ++P+ +EA P E + E E ++ AE
Sbjct: 1885 PESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAE 1944
Query: 951 KVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQ 1010
+ +E++ G PE + Q AE E E + L+ E V+ QEA+
Sbjct: 1945 EAAQEAE--GQTQPESEVIESQEAEEEAQPESEDVEALEVE------VETQEAE------ 1990
Query: 1011 GKVVGQTTPESFE-KAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPT 1069
G+ PES + +AP+ ++ +E +++ + E Q + ++ +T
Sbjct: 1991 ----GEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEG 2046
Query: 1070 DS--ETDG-STPVAD---FDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERP 1123
D+ E+DG P A+ +A G Q+ E E H E+E ++ E EA P + E
Sbjct: 2047 DAQPESDGVEAPEAEEEAQEAEGEVQEAE-GEAHPESEDVDAQEA---EGEAQP-ESEGV 2101
Query: 1124 PAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFF 1183
AP + ++ + E E + +E + + E + D + + P
Sbjct: 2102 EAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPES 2161
Query: 1184 EGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQV 1243
EG+E + E A + EG + E + +A E + A+ VE
Sbjct: 2162 EGIEAQ-EAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE----APE 2216
Query: 1244 EREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPP 1300
E+ + EP V + E E E + + V + DG E +S SP P
Sbjct: 2217 AEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVP 2273
Score = 92.0 bits (227), Expect = 4e-18
Identities = 145/700 (20%), Positives = 259/700 (37%), Gaps = 100/700 (14%)
Query: 106 DEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVE 165
++GEG+ KDP LG E + E + T E + E AE + G+ +
Sbjct: 1744 EDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAE-----QEGEGIS 1798
Query: 166 ECKEEGEEKQEKEPSKSAESPTS----PVTSETGSTFKKFFTQGWA-------------- 207
E E G + E + E+ P S+ + +G A
Sbjct: 1799 ERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEG 1858
Query: 208 GWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE----------EDGKAEVASEKLTASEQ 257
++ +P+ ++VEA E + E +PE D E E AE + A +
Sbjct: 1859 DAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPE 1918
Query: 258 AHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEV 317
E E+ E +E + + +EE ++G ++ + + ++ +E+ + E+V
Sbjct: 1919 TESVEALETEGEDEPESEGAEAQ-EAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDV 1977
Query: 318 VA-EVHVSTV----EERTEEQKTEVEETAGSV-PAEELVEMDAEPQEAEPAKELVKLKET 371
A EV V T E + E + E E G + AEE + +++ EA+P E + +E
Sbjct: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQE- 2036
Query: 372 CVSGEDPTQGADLSPDEKVLSKP--------PEGVVSEVEMLSSQERMKVQGSPLKKLFT 423
V GE D P+ + P EG V E E + E V
Sbjct: 2037 -VEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQ------E 2089
Query: 424 STGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEK 483
+ G + + + G+ + E + P ++Q E +G E PE +
Sbjct: 2090 AEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEG------IEAPE-----AE 2138
Query: 484 GLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRP-SESDKEDELDKVKS 542
G A+ + +G + A + + + EG+ + ++ + V P +E + + E + +++
Sbjct: 2139 GEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEA 2198
Query: 543 ATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDE 602
E Q E++G VE P+ EE + V E G ++ + + ++
Sbjct: 2199 ------PEAEGEAQPELEG-VEAPEAEEEAQPEPEGV--ETPEAEGEAQPESEGETQGEK 2249
Query: 603 EGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWE 662
+G P+ GD Q + + D P G +P Q G S
Sbjct: 2250 KGSPQVSLGDGQSEEASESSSPVPED-----RPTPPPSPGGDTPHQRPGSQTGPSSSRAS 2304
Query: 663 SFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPD 722
S+ ++ L + +G H+ ES S
Sbjct: 2305 SWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTS-------------- 2350
Query: 723 GKQEQAPVEDAGP-TGANE--DDSDVPAVVPLSEYDAVER 759
+QE+AP+ P GA+E D + A+ L+ +AV R
Sbjct: 2351 -EQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVGR 2389
Score = 85.1 bits (209), Expect = 5e-16
Identities = 224/1074 (20%), Positives = 406/1074 (37%), Gaps = 134/1074 (12%)
Query: 14 SEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESN--LEELTQPTESQAND 71
+ED ++RDS+++ A+ + + + ++ +E ++ E +E EE Q E++ +
Sbjct: 1272 NEDEAERDSEEQRASSN--LEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEE 1329
Query: 72 IGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAG----DHKDPSLGAGEA 127
++ + K T + + E + QL +++ GEG G + K+ G +
Sbjct: 1330 GLQEEGVQLEETKETEGEGQQE--EEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQG 1387
Query: 128 ASKESEPKQSTEKPEETLKREQSHAEISPP-------------AESGQA---VEECKEEG 171
+ E K+ PEE Q +E S P E+G+A E C EG
Sbjct: 1388 EALEEGLKEEG-LPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEG 1446
Query: 172 EEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQ--GWAGWRKKTSFRKPKEDEVEASEKK 229
E+ + PS +E+ S ++GS + + G ++ + +P + E S
Sbjct: 1447 TEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSV 1506
Query: 230 KEQEPEKVD----------TEEDGKAEVAS--EKLTASEQAHPQEPAESAHEPRLSAEYE 277
D TE+ A +AS +L A + + +
Sbjct: 1507 ACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQ 1566
Query: 278 KVELPSEEQVSGSQGPSE----EKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERT--- 330
+++ ++ ++ QG + E P T + + + + ++S ERT
Sbjct: 1567 RLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGL 1626
Query: 331 -EEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEK 389
T +E A S + +AE +E P + V+ K + +S + T GA P ++
Sbjct: 1627 GPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPK-ATMGATRGPIKE 1685
Query: 390 VLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGG-------- 441
++L + G + T S + +G GG
Sbjct: 1686 AFDLQ--------QILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQG 1737
Query: 442 ---GDEESGEHTQ-VPADSPDSQEEQKGESSASSPE----EPEEITCLEKGLAEVQQDGE 493
+ E GE +Q + D E +G++ A E E E G AE + +G
Sbjct: 1738 PGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGI 1797
Query: 494 AEEGAT-SDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTA 552
+E G T G + + A+ + P +SD + ++ ++ + ES
Sbjct: 1798 SERGETGGQGSGHEDNLQGEAA-------AGGDQDPGQSDGAEGIEAPEAEGEAQPESEG 1850
Query: 553 SEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRAR--RGSSSDEEGGPKAMG 610
E E +G +E + E D EA G ++ + ++ E P++ G
Sbjct: 1851 VE-APEAEGDAQEAEGEAQPESEDV----EAPEAEGEAQPESEDVETPEAEWEVQPESEG 1905
Query: 611 GDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTP 670
+ +A++ + + + + ++ +G+ + E + E EG + ES V
Sbjct: 1906 AEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPES---EVIE 1962
Query: 671 RKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPV 730
++++ + + +SED + VE T + E + ++ P + + ++E P
Sbjct: 1963 SQEAEEEAQPESED-VEALEVEVETQEAEGEAQPESEDVE--APEAEGEMQEAEEEAQPE 2019
Query: 731 ED---AGPTGANEDDSDVPAVVPLSEYDA-VEREKMEAQQAQKSAEQPEQKAATEVSKEL 786
D A P E+ +V +E DA E + +EA +A++ A++ E + +
Sbjct: 2020 SDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAH 2079
Query: 787 SESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAE 846
ES+ + A A+G E P +E +E EAE E +
Sbjct: 2080 PESE--DVDAQEAEG--------EAQPE------SEGVEAPEAEGEAQKAEGI------- 2116
Query: 847 EEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAE-EGTEASAAEETTEMV 905
E P T E PE+ EA+ E V A + G E EG EA AEE +
Sbjct: 2117 EAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ-- 2174
Query: 906 SAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPE 965
+ ++P+ EA P E G+ + E E Q L+ V EE P PE
Sbjct: 2175 -PELEGVEAPEAEGEAQPESE---GI-EAPEAEGEAQPELEGVEAPEAEEEAQP---EPE 2226
Query: 966 DVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTP 1019
V P EA+ PE + E G KK + V D Q + + + TP
Sbjct: 2227 GVETPEAEGEAQ-PESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTP 2279
Score = 76.6 bits (187), Expect = 2e-13
Identities = 184/887 (20%), Positives = 309/887 (34%), Gaps = 143/887 (16%)
Query: 834 LTEEVLEREVIAEE-EPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEG 892
L E ++ EV EE + T E L E +T E L E V ET G +
Sbjct: 1292 LAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEG-LQEEGVQLEETKETEGEGQQ 1350
Query: 893 TEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV----EGGVPDIEEQERRTQEVL--- 945
E + EE E T EE ++EV EGG+ +E +E L
Sbjct: 1351 EEEAQLEEIEE--------TGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEE 1402
Query: 946 -QAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAE---ASGLKKETDVVLKVDAQ 1001
+++ E S G G ED PVQ EA R AE A G ++ T+ +
Sbjct: 1403 GSVHGQELSEASSPDGKGSQED--DPVQEEEAGRASASAEPCPAEGTEEPTEP----PSH 1456
Query: 1002 EAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIP 1061
++T+P + G EK P T + T Q A +S + A+
Sbjct: 1457 LSETDPSASERQSGSQLEPGLEKPPGATMMGQEH---TQAQPTQGAAERSSSVACSAALD 1513
Query: 1062 PDSV-------ETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAE 1114
D + +T ++ VA+ A Q +++++ E +
Sbjct: 1514 CDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLD------------QMAAELQ 1561
Query: 1115 AVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYAD 1174
AQ+ + + + +E E E+ ++T + G + +++
Sbjct: 1562 QDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSE 1621
Query: 1175 EKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAEC-----KKDDALELQSHAK 1229
P L +++ +S +++ + EG E C KK + ++
Sbjct: 1622 RTLGLGP----LSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMG 1677
Query: 1230 SPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAK 1289
+ P++ +Q ++ E H + E E T ++ S + +Q + G
Sbjct: 1678 ATRGPIKEAFDLQQILQRKRGE--HTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLS 1735
Query: 1290 EVSSL------EGSP------PPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETA 1337
+ + EGS P LG+ E + + + +A +E + E
Sbjct: 1736 QGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGE 1795
Query: 1338 NILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKG 1397
I E GET H E N A G D P G
Sbjct: 1796 GISERGETGGQGSGH--------EDNLQGEAAAGGDQDP--------------------G 1827
Query: 1398 LSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQ 1457
S EG + + ++ E +E E E E E ++
Sbjct: 1828 QSDGAEGIEAPEAEGEAQPESE-----------GVEAPEAEGDAQEAEGEAQP------- 1869
Query: 1458 TAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAK 1517
+E+ E Q ++ ++ + + E EG E + ++ P T +
Sbjct: 1870 -------ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESV 1922
Query: 1518 EESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSV 1577
E E+ + S+ + EA E E EG T Q E V+ S+E A ++
Sbjct: 1923 EALETEGEDEPESE-GAEAQEAEEAAQ--EAEGQT----QPESEVIESQE----AEEEAQ 1971
Query: 1578 PEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQ 1637
PE + L +E E + + +DV+ PE + +A ES +
Sbjct: 1972 PESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEM---QEAEEEAQPESDGVEAQPK 2028
Query: 1638 KEKEDAQEVELQ----EGKVHSESDKAITPQAQEELQKQERESAKSE 1680
E E+AQEVE + EG ESD P+A+EE Q+ E E ++E
Sbjct: 2029 SEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAE 2075
Score = 76.3 bits (186), Expect = 2e-13
Identities = 127/558 (22%), Positives = 208/558 (37%), Gaps = 92/558 (16%)
Query: 11 QRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQAN 70
Q +SE +++KE ++ V + +G++E + +E +E T+ ++
Sbjct: 1900 QPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESE 1959
Query: 71 DIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASK 130
I ++ +++ + + V+ L V+ + E A
Sbjct: 1960 VIESQE----------AEEEAQPESEDVEALEVEVETQE------------------AEG 1991
Query: 131 ESEPK-QSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSP 189
E++P+ + E PE + +++ E P ++ +A + K EGEE QE E
Sbjct: 1992 EAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEA--QPKSEGEEAQEVE----------- 2038
Query: 190 VTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKE-QEPEKVDTEEDGKAEVA 248
G T K T+G A +P+ D VEA E ++E QE E E +G+A
Sbjct: 2039 -----GETQK---TEGDA---------QPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPE 2081
Query: 249 SEKLTASE-QAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFD 307
SE + A E + Q +E P E +K E + G P E E +
Sbjct: 2082 SEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE-----GIEAPE 2136
Query: 308 EKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSV-PAEELVEMDAEPQEAEPAKELV 366
+ E E E + E + E + E +E P E VE EA+P E +
Sbjct: 2137 AEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGI 2196
Query: 367 KLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTG 426
+ E + +G + E+ PEGV E + + + +G + G
Sbjct: 2197 EAPEAEGEAQPELEGVEAPEAEEEAQPEPEGV--ETPEAEGEAQPESEGE-------TQG 2247
Query: 427 LKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEE---PEEITCLEK 483
KK S + G G +E S + VP D P G++ P P
Sbjct: 2248 EKKGSPQVSLGD-GQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSW 2306
Query: 484 GLAEVQQDGEAEE--GATSDGEKKREGVTPWASFKKMVTPKKRVRR-PSESDKEDELDKV 540
G Q+D E + G T + K G TP A +K R P S E E +
Sbjct: 2307 GNC-WQKDSENDHVLGDTRSPDAKSTG-TPHAE-------RKATRMYPESSTSEQEEAPL 2357
Query: 541 KSATLSSTESTASEMQEE 558
S T S ++QE+
Sbjct: 2358 GSRTPEQGASEGYDLQED 2375
Score = 69.3 bits (168), Expect = 3e-11
Identities = 252/1209 (20%), Positives = 431/1209 (35%), Gaps = 199/1209 (16%)
Query: 552 ASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEG----GPK 607
A+ E + S E+ ++ + +V E + K G EE K
Sbjct: 1270 ATNEDEAERDSEEQRASSNLEQLAENTVQEEVQL---EETKEGTEGEGLQEEAVQLEETK 1326
Query: 608 AMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRL 667
G ++ + + KET +G Q+ + Q E G + EGV E
Sbjct: 1327 TEEGLQEEGVQLEETKETEGEG-----QQEEEAQLEEIEETGGEGLQEEGVQLEE----- 1376
Query: 668 VTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGK--Q 725
++E E + G +E + E EE V ++ PDGK Q
Sbjct: 1377 ----------VKEGPEGGLQGEALEEGLKE-EGLPEEGSVHGQEL---SEASSPDGKGSQ 1422
Query: 726 EQAPV--EDAGPTGANEDD-----SDVPAVVP--LSEYDAVEREKMEAQQAQKSAEQPEQ 776
E PV E+AG A+ + ++ P P LSE D E+ Q + E+P
Sbjct: 1423 EDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPP- 1481
Query: 777 KAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWIS-----------ASVTEPLE 825
AT + +E +++Q AA + A + + P W+S A + +
Sbjct: 1482 -GATMMGQEHTQAQP-TQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVA 1539
Query: 826 QVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA-----ELTPEAVTA 880
++ A L ++L++ +A E V + L ++ + + A E EA+T
Sbjct: 1540 ELRARWGLQDNDLLDQ--MAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTG 1597
Query: 881 A---ETAGPLGAEEGTE-ASAAEETTEMVSAVS-QLTDSP--DTTEEATPVQEVEGGVPD 933
+T G SA E T + +S L D P T + +E EG
Sbjct: 1598 ELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEG---- 1653
Query: 934 IEEQERRTQEVLQAVAEKVKEESQLPGTGGPE----DVLQPVQRAEAERPE-EQAEASGL 988
E+ + ++ + ++ + T GP D+ Q +QR E + E AE +
Sbjct: 1654 --EEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPG 1711
Query: 989 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESI--ESSELVTTCQAETL 1046
K TD Q A+ G P + P V E E S+ + + L
Sbjct: 1712 KTHTDPTSTRTVQGAE----------GGLGP-GLSQGPGVDEGEDGEGSQRLNRDKDPKL 1760
Query: 1047 AGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIV---EIHEEN--- 1100
+ M E+ + ET SE A+ + G +++ E HE+N
Sbjct: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGE----AEQEGEGISERGETGGQGSGHEDNLQG 1816
Query: 1101 EVASGT-----QSGGTEA-EAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1154
E A+G QS G E EA A+ E P + E E + E + + E
Sbjct: 1817 EAAAGGDQDPGQSDGAEGIEAPEAEGEAQP-------ESEGVEAPEAEGDAQEAEGEAQP 1869
Query: 1155 ETVSILSKTEGTQEADQYADEKTKDV-----PFFEGLEGSIDTGITVSREKVTEVALKGE 1209
E+ + + + + D +T + P EG E + E + AL+ E
Sbjct: 1870 ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAP-EAEKEAQPETESVEALETE 1928
Query: 1210 GTEEAECKKDDALELQSHAKSPPSPVEREM-VVQVEREKTEAEPTHVNEEKLEHETAVTV 1268
G +E E + +A E + A+ + E V++ + + EA+P + E LE E
Sbjct: 1929 GEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQE 1988
Query: 1269 SEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAE 1328
+E ++ + V P +G ++Q EA
Sbjct: 1989 AEGEAQPESEDVEAPEAEG-----------------------EMQEAEEEAQPESDGVEA 2025
Query: 1329 EEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPV 1388
+ K GE A +E GET + G A P D V P+ + +
Sbjct: 2026 QPKSEGEEAQEVE-GETQKTEGD----------------AQPESDGVEA-PEAEEE---- 2063
Query: 1389 IVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKV-SVAIEDLEPENGILELETK 1447
A +G + EGE +S++VD Q A E + S +E E E
Sbjct: 2064 ---AQEAEGEVQEAEGEAHP----ESEDVDAQEAEGEAQPESEGVEAPEAEG-------- 2108
Query: 1448 SSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQET--EKEGEEPQA 1505
++ + I + + E E +E + Q ++QDA E E EG E Q
Sbjct: 2109 EAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQE 2168
Query: 1506 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1565
+ ++ P E E A G+A + + +E E+EG + + E P
Sbjct: 2169 AEEEAQPELEGVEAPE--AEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPE 2226
Query: 1566 EEEGGGAGTKSVPEDDGHALLAERIEKSL-VEPKEDEKGDDVDDPENQNSALADTDASGG 1624
E A ++ PE +G ++ + + + E+ + P ++ G
Sbjct: 2227 GVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGD 2286
Query: 1625 LTKESPDT-NGPKQKE--------KEDAQEVELQEGKVHSESDKAITPQAQEELQKQERE 1675
+ P + GP ++D++ + ++ TP A+ + + E
Sbjct: 2287 TPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPE 2346
Query: 1676 SAKSELTES 1684
S+ SE E+
Sbjct: 2347 SSTSEQEEA 2355
Score = 48.9 bits (115), Expect = 4e-05
Identities = 222/1092 (20%), Positives = 374/1092 (34%), Gaps = 151/1092 (13%)
Query: 109 EGAAGAGDHKDPSL---GAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAES--GQA 163
E AG +DP L GAG ++ + EE + S + S S G
Sbjct: 492 ERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGR 551
Query: 164 VEECKEEGEEKQEKEPSKSAESPTSPVTSETG--STFKKFFTQGWAGWRKKTSFRKPKED 221
+ C + + ++ + P SP S + S + TQG G + T +E
Sbjct: 552 PQGCPGKARAETSQQEASEGGDPASPALSLSSLRSDDLQAETQG-QGTEQATGAAVTREP 610
Query: 222 EVEASEKKKEQE-----PEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEY 276
V + E P + + G+ S AS + P P PR +
Sbjct: 611 LVLGLSCSWDSEGASSTPSTCTSSQQGQRRHRSR---ASAMSSPSSPGLGRVAPRGHPRH 667
Query: 277 EKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTE 336
+ + S +++ P P E+ Q+ V S+ RT+
Sbjct: 668 SHYRKDTHSPLDSSV--TKQVPRP------PERRRACQDGSVPRYSGSSSSTRTQASGNL 719
Query: 337 VEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDP--TQGADLSPDEKVLSKP 394
++GS+P+++L + PA + VSG P A + D +
Sbjct: 720 RPPSSGSLPSQDL--LGTSSATVTPA-----VHSDFVSGVSPHNAPSAGWAGDAGSRTCS 772
Query: 395 PEGVVSEVEMLSSQERMKVQGSPLKKL-FTSTGLKKLSGKKQKGKRGGGDEESGEHTQVP 453
P + S+ G + S+ L G+ ++G G H
Sbjct: 773 PAPIPPHTSDSCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVG----PHRSHCCSQ 828
Query: 454 ADSPDSQEEQKGESSASS-------PEEPEEITCLEKGLAEVQQDGEAEEG-ATSDGEKK 505
+ +QE Q+G S +S P P C ++ + G + + A G
Sbjct: 829 PGTQPAQEAQRGPSPEASWLCGRYCPTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGGSP 888
Query: 506 REGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKG---- 561
+EG RR S S + TL S + QEE G
Sbjct: 889 QEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRS--GGGPQGQEEASGVSPS 946
Query: 562 SVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGK 621
S+ PE R+ ++ E ++ G++ GP+ GD + G+
Sbjct: 947 SLPRSSPEAVVREWLDNIPEEPILMTYELADETT-GAAGGGLRGPEVDPGDDHSLEGLGE 1005
Query: 622 DKETGTDGILAGSQEHDPGQGSSSPEQAGS--------PTEGEGVSTWESFKRLVTPRKK 673
+ G + E DPGQ PE G+ P GEGV + P
Sbjct: 1006 PAQAGQQSL-----EGDPGQ---DPEPEGALLGSSDTGPQSGEGV------PQGAAPEGV 1051
Query: 674 SKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDA 733
S++ E D A +G S PG+ + I + + G ++ RP E +
Sbjct: 1052 SEAP-AEAGADREAPAGCRVSL-RALPGRVSASTQIMRALMGSKQGRPSSVPEV-----S 1104
Query: 734 GPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKEL------S 787
P S + L+ E + + + P + +SK+L
Sbjct: 1105 RPMARRLSCSAGALITCLASLQLFEEDLGSPASKVRFKDSPRYQELLSISKDLWPGCDVG 1164
Query: 788 ESQVH------MMAAAVAD-GTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLE 840
E Q+ + A+ D G+ A T E +P+ S E+++
Sbjct: 1165 EDQLDSGLWELTWSQALPDLGSHAMT--ENFTPTSSSGVDISSGSGGSGESSVPCAMDGT 1222
Query: 841 REVIAEEEPPTVTEPLPENR--EARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAA 898
E P + P++R E+ GD + P + A A +E A
Sbjct: 1223 LVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDE------A 1276
Query: 899 EETTEMVSAVSQLTD-SPDTTEEATPVQEVEGGVPD-------IEEQERRTQEVLQAVAE 950
E +E A S L + +T +E ++E + G ++ +E +T+E LQ
Sbjct: 1277 ERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGV 1336
Query: 951 KVKEESQLPGTGGPEDVLQPVQRAEAERPE-EQAEASGLKKETDVVLKVDAQEAKTEPFT 1009
+++E + G G E+ EA+ E E+ GL++E V +E K P
Sbjct: 1337 QLEETKETEGEGQQEE--------EAQLEEIEETGGEGLQEE-----GVQLEEVKEGP-- 1381
Query: 1010 QGKVVGQTTPESFEKAPQVTE-SIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETP 1068
+G + G+ E ++ E S+ EL +A + G SQE + P
Sbjct: 1382 EGGLQGEALEEGLKEEGLPEEGSVHGQEL---SEASSPDGKGSQE------------DDP 1426
Query: 1069 TDSETDG--STPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAP 1126
E G S A GT + E E + ++ + G++ E E+PP
Sbjct: 1427 VQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLE---PGLEKPPG- 1482
Query: 1127 SSFVFQEETKEQ 1138
++ + QE T+ Q
Sbjct: 1483 ATMMGQEHTQAQ 1494
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 105 bits (263), Expect = 3e-22
Identities = 287/1355 (21%), Positives = 506/1355 (37%), Gaps = 229/1355 (16%)
Query: 11 QRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQAN 70
QR S + + K + +KS + + +EETPE+ + + + +P + ++
Sbjct: 537 QRADSRESLKPAAKPLPSKS-----VRKESKEETPEV--------TKVNHVEKPPKVESK 583
Query: 71 DIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVK----KDEGEGAAGAGDHKDPSLGAGE 126
+ K VKKDK K +T +T K K+E K + +
Sbjct: 584 E------------KVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPK 631
Query: 127 AASKESEPKQSTEKPE------ETLKREQSHAEISPPAESGQ------AVEECKEEGEEK 174
AA +++ K++ KPE E K+E + E P + + +E K+E +++
Sbjct: 632 AAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKE 691
Query: 175 QEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEP 234
++KEP K + T P E KK KK ++ KE + E + K+ +
Sbjct: 692 EKKEPKKEVKKETPP--KEVKKEVKK--------EEKKEVKKEEKEPKKEIKKLPKDAKK 741
Query: 235 EKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYE--KVELPSEEQVSGSQG 292
E K K+ E++ ++ + +A +P+ + + K E + E V+ + G
Sbjct: 742 SSTPLSEAKKPAALKPKVPKKEES-VKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVG 800
Query: 293 PSEEKPAPLAT---EVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEEL 349
A +A E+ E + ++ E + EV+ T P EL
Sbjct: 801 TGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLEL 860
Query: 350 VEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEV-EMLSSQ 408
+E + + +E EP + V KE + T+G SPDE + + EG + E L
Sbjct: 861 IEDEEKLKETEPVEAYVIQKE-----REVTKGPAESPDEGITTTEGEGECEQTPEELEPV 915
Query: 409 ERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESS 468
E+ V ++K + G G EES E + D +E+ + E +
Sbjct: 916 EKQGVD-----------DIEKFEDE------GAGFEESSE-------TGDYEEKAETEEA 951
Query: 469 ASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGE----KKREGVTPW--ASFKKMVTPK 522
E+ EE C+ A E EE A ++ + +KRE V + + M
Sbjct: 952 EEPEEDGEEHVCVS---ASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAI 1008
Query: 523 KRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPK----PEEPKRKVDTS 578
++ ++ DE DK + A E E ++ + V++ EE + T
Sbjct: 1009 EKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTP 1068
Query: 579 VSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHD 638
+G+ SS +E P + +DE +++E + A S
Sbjct: 1069 TKQ-----LGAQSPGREPASSIHDETLPGGSESEATASDE--ENREDQPEEFTATS---- 1117
Query: 639 PGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDT 698
G S+ E + PT + +ST R V + + + E S++ + + E S
Sbjct: 1118 -GYTQSTIEISSEPTPMDEMST----PRDVMSDETNNEETESPSQEFVNITKYESSLYSQ 1172
Query: 699 EPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVE 758
E K + F G + DGK A P + E+D
Sbjct: 1173 EYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDK--------------- 1217
Query: 759 REKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISA 818
++ A + A E KA+T + + S S V + + +SPS +S
Sbjct: 1218 ----FSRSALRDAYCSEVKASTTLDIKDSISAV-----------SSEKVSPSKSPS-LSP 1261
Query: 819 SVTEPLEQVE-AEAAL---LTEEVLEREVIAEEEP--PTVTEPLPENREARGDTVVSEAE 872
S PLE+ E ++ LT ++ AE P P VT+ + E A + E
Sbjct: 1262 SPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVV 1321
Query: 873 LTPEAVTAAETAGPLGAEEGTEASA--AEETTEMVSAVS---QLTDSPDTTEEATPVQEV 927
++VT + P E S+ E E AV + +D+ D E A+ V +
Sbjct: 1322 SPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERAS-VSPM 1380
Query: 928 EGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAE-------AERPE 980
+ VPD E + EKV + P G E + A+ AE P
Sbjct: 1381 DEPVPDSE-----------SPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPF 1429
Query: 981 EQA--------EASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESI 1032
E+ + S + + T L D QE K+ F K E F + + T+ +
Sbjct: 1430 EEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIK-------EDFGQEKK-TDDV 1481
Query: 1033 E--SSELVTTCQAETLAGVKSQEMVMEQ--AIPPD---SVETPTDSETDGSTPVADFDAP 1085
E SS+ L V ++ + Q + D S+ T S+ +TPV + A
Sbjct: 1482 EAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSD-KSATPVDEGVAE 1540
Query: 1086 GTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTL 1145
T H E + T S T + P + P+ + V + E ++D+L
Sbjct: 1541 DTYS-------HMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTE---VDDSL 1590
Query: 1146 EHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVA 1205
+ V+T + +TE + ++ + P F T + R + + ++
Sbjct: 1591 SVS----VVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMS 1646
Query: 1206 LKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQV-EREKTEAE--PTHVNEEKLEH 1262
+ E + + +L + +SP P V+ + E TE + P+ + + L H
Sbjct: 1647 I-----EFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSH 1701
Query: 1263 ETAVTVSEEVS----KQLLQTVNVPIIDGAKEVSS 1293
+ + EE S L + ++V ++ + SS
Sbjct: 1702 K--IPPMEEPSYTQDNDLSELISVSQVEASPSTSS 1734
Score = 84.3 bits (207), Expect = 9e-16
Identities = 307/1496 (20%), Positives = 533/1496 (35%), Gaps = 203/1496 (13%)
Query: 48 IEQIPSSESNLEELTQPTES-QANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKD 106
+E S S+ E+LT+ E +A ++ K K + ++K ++ + V+ ++K
Sbjct: 823 LEAERSLMSSPEDLTKDFEELKAEEVDVTKDIK-PQLELIEDEEKLKETEPVEAYVIQK- 880
Query: 107 EGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEE 166
E E G + D + E E E +Q+ E+ E K Q +I + G EE
Sbjct: 881 EREVTKGPAESPDEGITTTEG---EGECEQTPEELEPVEK--QGVDDIEKFEDEGAGFEE 935
Query: 167 CKEEG--EEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVE 224
E G EEK E E ++ E + S + A R+ +E
Sbjct: 936 SSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVAS 995
Query: 225 ASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSE 284
++ +E E + E G+AE + E+A ++ AE A E EYE ++ +E
Sbjct: 996 GDDRAEEDMDEAI---EKGEAE------QSEEEADEEDKAEDAREE----EYEPEKMEAE 1042
Query: 285 EQV------SGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVE 338
+ V + G +EE+ L T + E + +H T+ +E + T +
Sbjct: 1043 DYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASD 1102
Query: 339 E----------TAGSVPAEELVEMDAEP-------------------QEAE-PAKELVKL 368
E TA S + +E+ +EP +E E P++E V +
Sbjct: 1103 EENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNI 1162
Query: 369 K--ETCVSGEDPTQGADLSP---------DEKVLSKPPEGVVSEVEMLSSQERMKVQGSP 417
E+ + ++ ++ AD++P + K S + SS E K S
Sbjct: 1163 TKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSA 1222
Query: 418 LKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDS----QEEQKGESSASSPE 473
L+ + S +K + K E ++ P+ SP ++ GE S +
Sbjct: 1223 LRDAYCSE-VKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSL 1281
Query: 474 EPEEI-TCLEKGLAEVQQDGE---AEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPS 529
P EI E +A V + EE S +K E V+P S + P+
Sbjct: 1282 TPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPT 1341
Query: 530 ESDKE----DELDKVKSATLSSTESTASEMQEEMKGS-VEEPKP--EEPKRKVDTSVSWE 582
+ + ++K + +S S A + E S ++EP P E P KV + +
Sbjct: 1342 DEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSP 1401
Query: 583 ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGK-DKETGTDGILAGSQEHDPGQ 641
LI GS S+ D+ G A +K+ + G D+ + + + S D +
Sbjct: 1402 PLI--GSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQE 1459
Query: 642 GSSSP-----EQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTP 696
G S+ E G + + V S L +K + + S GS E
Sbjct: 1460 GKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKE---- 1515
Query: 697 DTEPGKEESWVSIKKFIP---GRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL-- 751
DT+ E VS K P G + + A V A ++ + V P
Sbjct: 1516 DTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLH 1575
Query: 752 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAA---TII 808
+E + +++ + + P TE+S E M + + A T +
Sbjct: 1576 AEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPV 1635
Query: 809 EERSPSWISASVTEPLEQVEAEAAL------------------LTE----EV------LE 840
++ S S+ E E A+ +TE EV ++
Sbjct: 1636 QDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQ 1695
Query: 841 REVIAEEEPPTVTEPLPENREARGDTVVSEAELTPE---AVTAAETAGPLGAEEGTEASA 897
++ + PP ++ + VS+ E +P A T ++ A PL + ++ +
Sbjct: 1696 DSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAP 1755
Query: 898 AEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQ 957
+ + S S+ S + E+ +P ++ P E VKE++
Sbjct: 1756 PRDMSLYASLTSEKVQSLEG-EKLSPKSDISPLTP--RESSPLYSPTFSDSTSAVKEKTA 1812
Query: 958 LPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQT 1017
+ P+ A AE +A + + L D E + GK G
Sbjct: 1813 TCHSSSSP----PIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDF 1868
Query: 1018 T-----PESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1072
+ PE ++P E + T + + G +++ P DS + E
Sbjct: 1869 SYAYQKPEETTRSPD-EEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYS---YE 1924
Query: 1073 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1132
T G T D D EI E+ + T G + + + PP S + ++
Sbjct: 1925 TIGKTTKTPEDG------DYSYEIIEKT---TRTPEEGGYSYDISEKTTSPPEVSGYSYE 1975
Query: 1133 EETKEQSKMEDTLE-HTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEG-SI 1190
+ + + ++D + D E T+ S Y+ E T+ + F EG S
Sbjct: 1976 KTERSRRLLDDISNGYDDSEDGGHTLGDPS----------YSYETTEKITSFPESEGYSY 2025
Query: 1191 DTGITVSREKVT-----EVALKGEGTEEAECKKDDALELQSHA-KSPPSPVEREMVV--- 1241
+T +R T E A K T +A + +L A K PS +++ +
Sbjct: 2026 ETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLV 2085
Query: 1242 ---QVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSP 1298
+ + KTE P+ +N LE + +EE K L Q+ P G K+
Sbjct: 2086 SSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDET 2145
Query: 1299 PPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEK 1358
PP E A S+ + EE + ANI E + ++
Sbjct: 2146 PPTSVSESA--------PSQTDSDVPPETEECPSITADANI-----DSEDESETIPTDKT 2192
Query: 1359 SSEKNEDFAAHPGEDAVPT--GPDCQAKSTPVI-VSATTKKGLSSDLEGEKTTSLK 1411
+ K+ D P +D P+ PD + + K L DL+ EKT + K
Sbjct: 2193 VTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLK-EKTKTKK 2247
Score = 71.6 bits (174), Expect = 6e-12
Identities = 250/1215 (20%), Positives = 426/1215 (35%), Gaps = 255/1215 (20%)
Query: 140 KPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFK 199
K + +R S + P A+ + KE EE E E P + E
Sbjct: 531 KQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKE------ 584
Query: 200 KFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLT-ASEQA 258
K +K K + E E+E + KAEVA ++ T +A
Sbjct: 585 ------------KVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKA 632
Query: 259 HPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVV 318
++ + + + + E+ E P +E +E P+ E +K EV ++EV
Sbjct: 633 AKEKTVKKETKVKPEDKKEEKEKPKKEVAK------KEDKTPIKKEEKPKKEEV-KKEVK 685
Query: 319 AEVHVSTVEERTEEQKTEV--EETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGE 376
E+ +E +E K E +E V EE E+ E E EP KE+ KL +
Sbjct: 686 KEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKE--EKEPKKEIKKLPKDAKKSS 743
Query: 377 DPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQK 436
P LS +K + P+ E +KK + G K GK +
Sbjct: 744 TP-----LSEAKKPAALKPKVPKKE--------------ESVKKDSVAAGKPKEKGKIKV 784
Query: 437 GKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEE 496
K+ G E+ + + G ++ +E E L ++ +D E
Sbjct: 785 IKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFE--- 841
Query: 497 GATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDE------LDKVKSATLSSTES 550
E K E V K + P+ + E KE E + K + T ES
Sbjct: 842 ------ELKAEEV----DVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAES 891
Query: 551 -----TASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGG 605
T +E + E + + EE +P E K+ VD +E DE G
Sbjct: 892 PDEGITTTEGEGECEQTPEELEPVE-KQGVDDIEKFE------------------DEGAG 932
Query: 606 --PKAMGGDHQ---KADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVST 660
+ GD++ + +EA + +E G + + + +H SPTE E
Sbjct: 933 FEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKH-------------SPTEDE---- 975
Query: 661 WESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKR 720
ES K ++ + + EK E +G D K E+ S +
Sbjct: 976 -ESAK------AEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQS-------EEEAD 1021
Query: 721 PDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREK--MEAQQAQKSAEQPEQKA 778
+ K E A E+ P +D + V +E E + + Q A+ P ++
Sbjct: 1022 EEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREP 1081
Query: 779 ATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISAS--VTEPLEQVEAEAALLTE 836
A+ + E A A + R E P +A+ T+ ++ +E + E
Sbjct: 1082 ASSIHDETLPGGSESEATASDEENR------EDQPEEFTATSGYTQSTIEISSEPTPMDE 1135
Query: 837 EVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEAS 896
R+V+++E TE ++E T + + E A+ G EG++
Sbjct: 1136 MSTPRDVMSDETNNEETE--SPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTD 1193
Query: 897 AAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQ-AVAEKVKEE 955
A TD D A+ + P E+++ ++ L+ A +VK
Sbjct: 1194 A--------------TDGKDYNASASTISP-----PSSMEEDKFSRSALRDAYCSEVKAS 1234
Query: 956 SQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVG 1015
+ L D+ + +E+ S +
Sbjct: 1235 TTL-------DIKDSISAVSSEKVSPSKSPS---------------------------LS 1260
Query: 1016 QTTPESFEKAP----QVTESIESSELVTTCQAET--LAGVKSQEMVMEQAIPPD----SV 1065
+ P EK P V S+ +E+ + +AE ++ +QE+V E P+ V
Sbjct: 1261 PSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEV 1320
Query: 1066 ETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPA 1125
+P+ S T + + +P T +K H EV E+PPA
Sbjct: 1321 VSPSQSVTGSAGHTPYYQSP-TDEKSS----HLPTEVI-----------------EKPPA 1358
Query: 1126 -PSSFVFQEETKEQ-----SKMEDTLEHTDKEV--------SVETVSILSKTEGTQEADQ 1171
P SF F + E S M++ + ++ + S + S E AD
Sbjct: 1359 VPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADD 1418
Query: 1172 YADEKTKDVPFFE--GLEGSIDTGITVSREKVTEV---ALKGEGTEEAECKKDDALELQS 1226
A + + PF E G +GS D VS T + +G+ T+ A K+D E ++
Sbjct: 1419 KASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKT 1478
Query: 1227 HAKSPPSPVEREMVVQVEREKTEAEPTHVNEEK---LEHETAVTVSEEVSKQLLQTVNVP 1283
S + + ER+ + PT ++ + + +T +++SE T P
Sbjct: 1479 DDVEAMS--SQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSAT---P 1533
Query: 1284 IIDGAKE--VSSLEG 1296
+ +G E S +EG
Sbjct: 1534 VDEGVAEDTYSHMEG 1548
Score = 35.8 bits (81), Expect = 0.36
Identities = 102/451 (22%), Positives = 165/451 (36%), Gaps = 90/451 (19%)
Query: 135 KQSTEKPEET-LKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSE 193
+++T PEE + S SPP SG + E K E + + S + SE
Sbjct: 1944 EKTTRTPEEGGYSYDISEKTTSPPEVSGYSYE--KTERSRRLLDDISNGYDD------SE 1995
Query: 194 TGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLT 253
G + + K TSF + + E S K E +EK+T
Sbjct: 1996 DGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYE------TAEKIT 2049
Query: 254 ASEQA--------------HPQEPAESAHEPRL----SAEYE--KVEL------PSEEQV 287
+ QA + P+E+ + L S EY+ K EL P+ +
Sbjct: 2050 RTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEW 2109
Query: 288 SGSQGPSEEKPAPL-----ATEVFDEKIEVHQEEVVAEVHVS-TVEERTEEQKTEVEETA 341
S+ P+EE PL A K + Q + VS + +T+ E
Sbjct: 2110 FASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEEC 2169
Query: 342 GSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSE 401
S+ A+ ++ + E E P + V K P D SP + P+ + +
Sbjct: 2170 PSITADANIDSEDE-SETIPTDKTVTYKHM---DPPPAPVQDRSPSPR----HPDVSMVD 2221
Query: 402 VEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQE 461
E L+ ++ + LKK +K K K+ G T+ + SP +
Sbjct: 2222 PEALAIEQNL------------GKALKKDLKEKTKTKKPG--------TKTKSSSPVKKS 2261
Query: 462 EQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTP 521
+ K + A+SP+ GL E +++ + KK+E V A K TP
Sbjct: 2262 DGKSKPLAASPKPA--------GLKE-----SSDKVSRVASPKKKESVEKAA--KPTTTP 2306
Query: 522 KKRVRRPSESDKEDELDKVKSATLSSTESTA 552
+ + R E DKE + SA+ S+ +TA
Sbjct: 2307 EVKAARGEEKDKETKNAANASASKSAKTATA 2337
Score = 35.4 bits (80), Expect = 0.47
Identities = 42/192 (21%), Positives = 81/192 (42%), Gaps = 11/192 (5%)
Query: 1499 EGEEPQASAQDETPITSAKEES--ESTAVGQAHSDISKDMSEASEKTMTVEVEG-STVND 1555
+ E A P S ++ES E+ V + + E+ EK M + + T
Sbjct: 540 DSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETK 599
Query: 1556 QQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSA 1615
+ E +PS+EE + + EK++ + + + D ++ E
Sbjct: 600 PSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKE 659
Query: 1616 LADTDASGGLTKESPDTNGPKQKE--KEDAQEVELQEGKVHSESDKAITP--QAQEELQK 1671
+A + + KE PK++E KE +E++ +E K + K TP + ++E++K
Sbjct: 660 VAKKEDKTPIKKEEK----PKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKK 715
Query: 1672 QERESAKSELTE 1683
+E++ K E E
Sbjct: 716 EEKKEVKKEEKE 727
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
sapiens]
Length = 1411
Score = 101 bits (252), Expect = 5e-21
Identities = 294/1530 (19%), Positives = 551/1530 (36%), Gaps = 220/1530 (14%)
Query: 223 VEASEKKKEQEPEKVDTEEDGKA-EVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVEL 281
V A+ + KEQ +K + ++ + SE ++ E A L A+ +V
Sbjct: 24 VRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDA---ALQAKKTRVSD 80
Query: 282 PSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETA 341
P +S S+ EE+ A T ++ V+ S+++E+ + + + +T
Sbjct: 81 P----ISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTG 136
Query: 342 GSVP-------AEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKP 394
S+P L+ + + AEP+ + ET G P GA P +
Sbjct: 137 NSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPG---MVSA 193
Query: 395 PEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEES--GEHTQV 452
+ S + SS + V+ +K+ + + KG G G + G+ V
Sbjct: 194 GQADSSSEDTSSSSDETDVEVKASEKILQV----RAASAPAKGTPGKGATPAPPGKAGAV 249
Query: 453 PADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEE-GATSDGEKK--REGV 509
+ + + E+ ESS+ + EE T K L + + G+ + GA S K+ R+G
Sbjct: 250 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 309
Query: 510 TPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPE 569
P K K E D + ++ S + ++ S +++ + P E
Sbjct: 310 APAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA-SAPAKE 368
Query: 570 EPKRKVDTSVSWE-----ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKE 624
P++ + + A + VG ++ +R S + + + GK +
Sbjct: 369 SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQ 428
Query: 625 TGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSED 684
+ G G G P + G T V WE + S+S EE S+
Sbjct: 429 VKPASTM-GMGPLGKGAGPVPPGKVGPATPSAQVGKWE---------EDSESSSEESSDS 478
Query: 685 SIAGSGVEHSTPDT-EPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDS 743
S + P P +E+S +I + +P + P + AGP
Sbjct: 479 S------DGEVPTAVAPAQEKSLGNILQ-------AKPTSSPAKGPPQKAGPVAVQ---- 521
Query: 744 DVPAVVPLSEYDAVEREK-----------MEAQQAQKSAEQPEQKAATEVSKELSESQVH 792
V A P+ ++ E M A QA+ + + P+ KA + + + ++V
Sbjct: 522 -VKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVA 580
Query: 793 MMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTV 852
+ +A T SP+ S +V ++ +++ E +EEE +
Sbjct: 581 PVRVGTQAPRKAGTAT---SPAGSSPAVAGGTQRPAEDSSS------SEESDSEEEKTGL 631
Query: 853 TEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLT 912
+ + + V A + + TA L + G T V A Q
Sbjct: 632 AVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGP-------TVTQVKAEKQ-- 682
Query: 913 DSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT-GGPEDVLQPV 971
+ +++EE + +E ++ ++TQ A + GT P V+
Sbjct: 683 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAK---GTISAPGKVVTAA 739
Query: 972 QRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTES 1031
+A+ P + + + V+ + A QT PE E + E
Sbjct: 740 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE--EDSGSSEEE 797
Query: 1032 IESSELVTTCQAETLAGVKSQEMV--MEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQ 1089
+S E +AETLA VK + A+ P +S G+ P PG T
Sbjct: 798 SDSEE-----EAETLAQVKPSGKTHQIRAALAPAK-----ESPRKGAAPTP----PGKTG 843
Query: 1090 KDEIVEIHEENEVASGTQS---GGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE 1146
+++ +S +S G A AQ +PP +F + + + T
Sbjct: 844 PSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPP----LIFVDPNRSPAGPAATPA 899
Query: 1147 HTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVAL 1206
+ T +E T + E +P + L I T + +A
Sbjct: 900 QAQ---AASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAP 956
Query: 1207 KG---------EGTEEAECKKDDALELQSHAKSPPS-PVEREMVVQVEREKTEAEPTHVN 1256
K E + ++ KK + Q K+P S P+ + + + ++ +EA+P
Sbjct: 957 KASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVAR 1016
Query: 1257 EEKLEH-ETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQ 1315
+ ++AV S Q AK + L P + ++A
Sbjct: 1017 TQPSSGVDSAVGTLPATSPQSTSVQ-------AKGTNKLRKPKLPEV--QQATKAPESSD 1067
Query: 1316 SSEASFTLTAAAEEEKVLGETANILETGETL--EPAGAHLVLEEKSSEKNEDFAAHPGED 1373
SE S ++ +EE+ GE ++ TL P+ ++EE ++E +ED P +
Sbjct: 1068 DSEDSSDSSSGSEED---GEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQS 1124
Query: 1374 AVP-------TGPDCQA-KSTPVIVSA---TTKKGLSSDLEGEKTTSLKWKSDEVDEQVA 1422
+ T + QA K+TP + S+ ++ D +G++ + + + +
Sbjct: 1125 LLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTG 1184
Query: 1423 CQEVKVSVAIE-DLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQ 1481
+E + +P+ G + + L NI Q + Q +E Q Q
Sbjct: 1185 GKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQ---------PWPLNEAQVQ 1235
Query: 1482 AHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMS---- 1537
A V+K ++ QE +K + + S++ K + A S K +
Sbjct: 1236 ASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEG 1295
Query: 1538 -EAS---EKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGA----GTKSVPEDDGHALLAER 1589
EAS EKT T +G D+ +V E++G G+ G K PE E
Sbjct: 1296 GEASVSPEKTSTTS-KGKAKRDKASGDV---KEKKGKGSLGSQGAKDEPE--------EE 1343
Query: 1590 IEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQ 1649
++K + +G D +P+++ K+K+K D ++ + +
Sbjct: 1344 LQKGM----GTVEGGDQSNPKSK-----------------------KEKKKSDKRKKDKE 1376
Query: 1650 EGKVHSESDKAITPQAQEELQKQERESAKS 1679
+ + ++ KA T ++ QK++++ K+
Sbjct: 1377 KKEKKKKAKKASTKDSESPSQKKKKKKKKT 1406
Score = 72.8 bits (177), Expect = 3e-12
Identities = 230/1181 (19%), Positives = 400/1181 (33%), Gaps = 242/1181 (20%)
Query: 140 KPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFK 199
K EE + +S P + ++ EE +EE E + K + A + +S + ++ S+ K
Sbjct: 64 KAEEDAALQAKKTRVSDPISTSESSEE-EEEAEAETAKATPRLASTNSSVLGADLPSSMK 122
Query: 200 -KFFTQGWAGWRKKTSFRKPKEDEVEAS-----EKKKEQEPEK-----VDTEEDGKAEV- 247
K + + S P + A+ +K EP +TEE+G
Sbjct: 123 EKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAF 182
Query: 248 ---ASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEE---QVSGSQGPSEEKPAPL 301
A + ++ QA S+ + S++ VE+ + E QV + P++ P
Sbjct: 183 GAAAKPGMVSAGQAD-----SSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKG 237
Query: 302 ATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEET-------------------AG 342
AT K + A E +EE EET A
Sbjct: 238 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 297
Query: 343 SVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL--SKPPEGVVS 400
S PA+E A P V + ED ++ S E+ P G
Sbjct: 298 SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP 357
Query: 401 EVEMLSS--QERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPD 458
+V S+ +E + +P T ++ KQ+ EES + A
Sbjct: 358 QVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNA 417
Query: 459 SQEEQKGESSASSPEEPEEITCLEKGLAEVQ-----------QDGEAEEGATSDGEKKRE 507
+Q + G+S P + L KG V Q G+ EE + S E+ +
Sbjct: 418 AQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 477
Query: 508 ---GVTPWA-------------SFKKMVTPKK-------------RVRRPSESDKEDELD 538
G P A K +P K + +P ++ + E
Sbjct: 478 SSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSE-- 535
Query: 539 KVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWE-ALICVGSSKKRARRG 597
S + S E+ A+ + K +++ P+ + +K +T+ S + A + VG+ R
Sbjct: 536 -ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGT 594
Query: 598 SSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEG 657
++S P GG + P + SSS E++ S E G
Sbjct: 595 ATSPAGSSPAVAGGTQR------------------------PAEDSSSSEESDSEEEKTG 630
Query: 658 VSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRR 717
++ V K L+ K+ + T PG
Sbjct: 631 LAV------TVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG---------------- 668
Query: 718 KKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQK 777
K P Q +A ++ + E DS+ A P +V++ + +A A +A P K
Sbjct: 669 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAK 726
Query: 778 AATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQ----------- 826
+A AA ++RSPS + V P
Sbjct: 727 GT---------------ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVP 771
Query: 827 -------VEAEAALLTEE---VLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPE 876
A+A EE E E +EEE T+ + P + + ++ A+ +P
Sbjct: 772 SVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPR 831
Query: 877 ---AVTAAETAGPLGAEEGTE---ASAAEETTEMVSAVSQLTDS-----------PDTT- 918
A T GP A+ G + S++EE+ A + +T + P+ +
Sbjct: 832 KGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSP 891
Query: 919 --EEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT--------------- 961
ATP Q P + R ++ ++ + + ++E +P T
Sbjct: 892 AGPAATPAQAQAASTP---RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMP 948
Query: 962 GGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQG--KVVGQTTP 1019
+ A A +E + S KK+ +V + + P TQ KV+ Q
Sbjct: 949 TAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKAS 1008
Query: 1020 ESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPV 1079
E+ + S V T A S + QA + + P E +T
Sbjct: 1009 EAQPPVARTQPSSGVDSAVGTLPA------TSPQSTSVQAKGTNKLRKPKLPEVQQAT-- 1060
Query: 1080 ADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQS 1139
AP ++ E + ++ +SG++ G + + P PS + ++
Sbjct: 1061 ---KAPESSDDSE-----DSSDSSSGSEEDGEGPQGAKSAHTLGPTPS--------RTET 1104
Query: 1140 KMEDT-LEHTDKEVSVETVSILS--KTEGTQEADQYADEKT 1177
+E+T E ++ +V + S+LS T G A+ A + T
Sbjct: 1105 LVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKAT 1145
Score = 59.7 bits (143), Expect = 2e-08
Identities = 236/1166 (20%), Positives = 407/1166 (34%), Gaps = 194/1166 (16%)
Query: 118 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEK 177
K +GA A +KES K + P + A+ E Q+ E + +E+
Sbjct: 290 KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQS----SSEESDSEEE 345
Query: 178 EPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKV 237
P+++ S +P + K+ +G A + + + +V E+ E+
Sbjct: 346 APAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES 405
Query: 238 DTEEDGKAEVASEKLTASEQAHPQEPAE---------------------SAHEPRLSAEY 276
D++ + A + + ++ ++ +PA + ++
Sbjct: 406 DSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWE 465
Query: 277 EKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAE--------VHVSTVEE 328
E E SEE S G AP + ++ A+ V V E
Sbjct: 466 EDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 525
Query: 329 RTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSP-- 386
+ + EE++ S +EE Q A+PA ++ + K C + T A ++P
Sbjct: 526 KPMDNSESSEESSDSADSEEAPAAMTAAQ-AKPALKIPQTK-ACPKKTNTTASAKVAPVR 583
Query: 387 -----DEKV----------------LSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTST 425
K +P E S E S +E+ + + +
Sbjct: 584 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 643
Query: 426 GLK-KLSGKKQKGKRGGG------DEESGEHTQVPA----DSPDSQEEQKGESSASSPEE 474
GL+ K + KG G G + TQV A DS S+EE E +A+SP +
Sbjct: 644 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 703
Query: 475 PEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKR--VRRPSESD 532
+ T ++K A+ A + VT A K+ K + VR P S
Sbjct: 704 VK--TSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNST 761
Query: 533 KEDELDKVKSATLSSTESTASEMQ---EEMKGSVEEPKPEEPKRKVDTSV-----SWEAL 584
++ +TA++ Q EE GS EE E + + V + +
Sbjct: 762 VLAR-GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIR 820
Query: 585 ICVGSSKKRARRGSSSDEEG--GPKAMGGDHQKADEAGKDKETGTDGILAGSQEH----- 637
+ +K+ R+G++ G GP A Q D +E+ +DG +
Sbjct: 821 AALAPAKESPRKGAAPTPPGKTGPSAAQAGKQD-DSGSSSEESDSDGEAPAAVTSAQVIK 879
Query: 638 ------DPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 691
DP + + P A +P + + S TPRK S E + S + S
Sbjct: 880 PPLIFVDPNRSPAGP--AATPAQAQAAS---------TPRKARAS--ESTARSSSSESED 926
Query: 692 EHSTPDTE---PGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAV 748
E P T+ PG + V++ P AP ++++ S +
Sbjct: 927 EDVIPATQCLTPGIRTNVVTM-----------PTAHPRIAPKASMAGASSSKESSRIS-- 973
Query: 749 VPLSEYDAVEREKMEAQQAQKS-AEQPEQKAATEV-SKELSESQVHMMAAAVADGTRAAT 806
D ++E Q ++K+ A P +AA +V +++ SE+Q + + G +A
Sbjct: 974 ------DGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAV 1027
Query: 807 -IIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGD 865
+ SP S V+A+ L + + E + T ++ E D
Sbjct: 1028 GTLPATSPQSTS---------VQAKGT----NKLRKPKLPEVQQATKAPESSDDSEDSSD 1074
Query: 866 TVVSEAE--LTPEAVTAAETAGPLGAEEGT--EASAAEETTEMVSAVSQLTDSPDTTEEA 921
+ E P+ +A T GP + T E +AAE + + V A SQ S T
Sbjct: 1075 SSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGL 1134
Query: 922 TPV-QEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQ--------LPGTGGPEDV--LQP 970
TP + P ++ + + K+E++ P TGG E P
Sbjct: 1135 TPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTP 1194
Query: 971 VQRAEAERPEEQAEASGLKKETDVV------------LKVDAQEAK--TEPFTQ-GKVVG 1015
+ + ++ +AS L ++++ +V A K TE Q K V
Sbjct: 1195 QKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVV 1254
Query: 1016 QTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVM----EQAIPPDSVETPTDS 1071
TT ES K + + S + A T K +++ E ++ P+ +T T S
Sbjct: 1255 DTTKESSRKGWESRKRKLSGDQPA---ARTPRSKKKKKLGAGEGGEASVSPE--KTSTTS 1309
Query: 1072 ETDGSTPVADFDAPGTTQKDEI------VEIHEENEVASGTQSGGTEAEAVPAQKERPPA 1125
+ A D K + E EE + GT GG ++ P K+
Sbjct: 1310 KGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSN--PKSKKEKKK 1367
Query: 1126 PSSFVFQEETKEQSKMEDTLEHTDKE 1151
+E KE+ K D E
Sbjct: 1368 SDKRKKDKEKKEKKKKAKKASTKDSE 1393
Score = 39.7 bits (91), Expect = 0.025
Identities = 49/190 (25%), Positives = 78/190 (41%), Gaps = 21/190 (11%)
Query: 1495 ETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVN 1554
ETE+EG P A + + SA GQA S S+D S +S++T VEV+ S
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSA---------GQADSS-SEDTSSSSDET-DVEVKAS--- 217
Query: 1555 DQQLEEVVLPSEEEGGGAGTKSVPEDDGHA-LLAERIEKSLVEPKEDEKGDDVDDPENQN 1613
+++ +V S G G + P G A +A + + E + ++ D E +
Sbjct: 218 -EKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEET 276
Query: 1614 ---SALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQ 1670
AL ASG ++ + K+ ++ A GK KA + +E+ Q
Sbjct: 277 PAAKALLQAKASGKTSQVGAASAPAKESPRKGA--APAPPGKTGPAVAKAQAGKREEDSQ 334
Query: 1671 KQERESAKSE 1680
ES E
Sbjct: 335 SSSEESDSEE 344
Score = 35.4 bits (80), Expect = 0.47
Identities = 29/140 (20%), Positives = 57/140 (40%), Gaps = 17/140 (12%)
Query: 118 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEE-CKEEGEEKQE 176
K LGAGE P++++ + KR+++ ++ G + K+E EE+ +
Sbjct: 1286 KKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ 1345
Query: 177 KEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEK 236
K S S+ ++K K K+D+ + +KKK ++
Sbjct: 1346 KGMGTVEGGDQSNPKSK----------------KEKKKSDKRKKDKEKKEKKKKAKKAST 1389
Query: 237 VDTEEDGKAEVASEKLTASE 256
D+E + + +K TA +
Sbjct: 1390 KDSESPSQKKKKKKKKTAEQ 1409
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 101 bits (251), Expect = 7e-21
Identities = 294/1531 (19%), Positives = 551/1531 (35%), Gaps = 221/1531 (14%)
Query: 223 VEASEKKKEQEPEKVDTEEDGKA-EVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVEL 281
V A+ + KEQ +K + ++ + SE ++ E A L A+ +V
Sbjct: 24 VRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDA---ALQAKKTRVSD 80
Query: 282 PSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETA 341
P +S S+ EE+ A T ++ V+ S+++E+ + + + +T
Sbjct: 81 P----ISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTG 136
Query: 342 GSVP-------AEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKP 394
S+P L+ + + AEP+ + ET G P GA P +
Sbjct: 137 NSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPG---MVSA 193
Query: 395 PEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEES--GEHTQV 452
+ S + SS + V+ +K+ + + KG G G + G+ V
Sbjct: 194 GQADSSSEDTSSSSDETDVEVKASEKILQV----RAASAPAKGTPGKGATPAPPGKAGAV 249
Query: 453 PADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEE-GATSDGEKK--REGV 509
+ + + E+ ESS+ + EE T K L + + G+ + GA S K+ R+G
Sbjct: 250 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 309
Query: 510 TPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPE 569
P K K E D + ++ S + ++ S +++ + P E
Sbjct: 310 APAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA-SAPAKE 368
Query: 570 EPKRKVDTSVSWE-----ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKE 624
P++ + + A + VG ++ +R S + + + GK +
Sbjct: 369 SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQ 428
Query: 625 TGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSED 684
+ G G G P + G T V WE + S+S EE S+
Sbjct: 429 VKPASTM-GMGPLGKGAGPVPPGKVGPATPSAQVGKWE---------EDSESSSEESSDS 478
Query: 685 SIAGSGVEHSTPDT-EPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDS 743
S + P P +E+S +I + +P + P + AGP
Sbjct: 479 S------DGEVPTAVAPAQEKSLGNILQ-------AKPTSSPAKGPPQKAGPVAVQ---- 521
Query: 744 DVPAVVPLSEYDAVEREK-----------MEAQQAQKSAEQPEQKAATEVSKELSESQVH 792
V A P+ ++ E M A QA+ + + P+ KA + + + ++V
Sbjct: 522 -VKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVA 580
Query: 793 MMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTV 852
+ +A T SP+ S +V ++ +++ E +EEE +
Sbjct: 581 PVRVGTQAPRKAGTAT---SPAGSSPAVAGGTQRPAEDSSS------SEESDSEEEKTGL 631
Query: 853 TEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLT 912
+ + + V A + + TA L + G T V A Q
Sbjct: 632 AVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGP-------TVTQVKAEKQ-- 682
Query: 913 DSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT-GGPEDVLQPV 971
+ +++EE + +E ++ ++TQ A + GT P V+
Sbjct: 683 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAK---GTISAPGKVVTAA 739
Query: 972 QRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTES 1031
+A+ P + + + V+ + A QT PE E + E
Sbjct: 740 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE--EDSGSSEEE 797
Query: 1032 IESSELVTTCQAETLAGVKSQEMV--MEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQ 1089
+S E +AETLA VK + A+ P +S G+ P PG T
Sbjct: 798 SDSEE-----EAETLAQVKPSGKTHQIRAALAPAK-----ESPRKGAAPTP----PGKTG 843
Query: 1090 KDEIVEIHEENEVASGTQS---GGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE 1146
+++ +S +S G A AQ +PP +F + + + T
Sbjct: 844 PSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPP----LIFVDPNRSPAGPAATPA 899
Query: 1147 HTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVAL 1206
+ T +E T + E +P + L I T + +A
Sbjct: 900 QAQ---AASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAP 956
Query: 1207 KG---------EGTEEAECKKDDALELQSHAKSPPS-PVEREMVVQVEREKTEAEPTHVN 1256
K E + ++ KK + Q K+P S P+ + + + ++ +EA+P
Sbjct: 957 KASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVAR 1016
Query: 1257 EEKLEH-ETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQ 1315
+ ++AV S Q AK + L P + ++A
Sbjct: 1017 TQPSSGVDSAVGTLPATSPQSTSVQ-------AKGTNKLRKPKLPEV--QQATKAPESSD 1067
Query: 1316 SSEASFTLTAAAEEEKVLGETANILETGETL---EPAGAHLVLEEKSSEKNEDFAAHPGE 1372
SE S ++ +EE+ GE ++ TL P+ ++EE ++E +ED P +
Sbjct: 1068 DSEDSSDSSSGSEED---GEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQ 1124
Query: 1373 DAVP-------TGPDCQA-KSTPVIVSA---TTKKGLSSDLEGEKTTSLKWKSDEVDEQV 1421
+ T + QA K+TP + S+ ++ D +G++ + + + +
Sbjct: 1125 SLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKT 1184
Query: 1422 ACQEVKVSVAIE-DLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQT 1480
+E + +P+ G + + L NI Q + Q +E Q
Sbjct: 1185 GGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQ---------PWPLNEAQV 1235
Query: 1481 QAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMS--- 1537
QA V+K ++ QE +K + + S++ K + A S K +
Sbjct: 1236 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGE 1295
Query: 1538 --EAS---EKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGA----GTKSVPEDDGHALLAE 1588
EAS EKT T +G D+ +V E++G G+ G K PE E
Sbjct: 1296 GGEASVSPEKTSTTS-KGKAKRDKASGDV---KEKKGKGSLGSQGAKDEPE--------E 1343
Query: 1589 RIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVEL 1648
++K + +G D +P+++ K+K+K D ++ +
Sbjct: 1344 ELQKGM----GTVEGGDQSNPKSK-----------------------KEKKKSDKRKKDK 1376
Query: 1649 QEGKVHSESDKAITPQAQEELQKQERESAKS 1679
++ + ++ KA T ++ QK++++ K+
Sbjct: 1377 EKKEKKKKAKKASTKDSESPSQKKKKKKKKT 1407
Score = 73.2 bits (178), Expect = 2e-12
Identities = 222/1146 (19%), Positives = 378/1146 (32%), Gaps = 229/1146 (19%)
Query: 140 KPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFK 199
K EE + +S P + ++ EE +EE E + K + A + +S + ++ S+ K
Sbjct: 64 KAEEDAALQAKKTRVSDPISTSESSEE-EEEAEAETAKATPRLASTNSSVLGADLPSSMK 122
Query: 200 -KFFTQGWAGWRKKTSFRKPKEDEVEAS-----EKKKEQEPEK-----VDTEEDGKAEV- 247
K + + S P + A+ +K EP +TEE+G
Sbjct: 123 EKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAF 182
Query: 248 ---ASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEE---QVSGSQGPSEEKPAPL 301
A + ++ QA S+ + S++ VE+ + E QV + P++ P
Sbjct: 183 GAAAKPGMVSAGQAD-----SSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKG 237
Query: 302 ATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEET-------------------AG 342
AT K + A E +EE EET A
Sbjct: 238 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 297
Query: 343 SVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL--SKPPEGVVS 400
S PA+E A P V + ED ++ S E+ P G
Sbjct: 298 SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP 357
Query: 401 EVEMLSS--QERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPD 458
+V S+ +E + +P T ++ KQ+ EES + A
Sbjct: 358 QVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNA 417
Query: 459 SQEEQKGESSASSPEEPEEITCLEKGLAEVQ-----------QDGEAEEGATSDGEKKRE 507
+Q + G+S P + L KG V Q G+ EE + S E+ +
Sbjct: 418 AQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 477
Query: 508 ---GVTPWA-------------SFKKMVTPKK-------------RVRRPSESDKEDELD 538
G P A K +P K + +P ++ + E
Sbjct: 478 SSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSE-- 535
Query: 539 KVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWE-ALICVGSSKKRARRG 597
S + S E+ A+ + K +++ P+ + +K +T+ S + A + VG+ R
Sbjct: 536 -ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGT 594
Query: 598 SSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEG 657
++S P GG + P + SSS E++ S E G
Sbjct: 595 ATSPAGSSPAVAGGTQR------------------------PAEDSSSSEESDSEEEKTG 630
Query: 658 VSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRR 717
++ V K L+ K+ + T PG
Sbjct: 631 LAV------TVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG---------------- 668
Query: 718 KKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQK 777
K P Q +A ++ + E DS+ A P +V++ + +A A +A P K
Sbjct: 669 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAK 726
Query: 778 AATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQ----------- 826
+A AA ++RSPS + V P
Sbjct: 727 GT---------------ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVP 771
Query: 827 -------VEAEAALLTEE---VLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPE 876
A+A EE E E +EEE T+ + P + + ++ A+ +P
Sbjct: 772 SVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPR 831
Query: 877 ---AVTAAETAGPLGAEEGTE---ASAAEETTEMVSAVSQLTDS-----------PDTT- 918
A T GP A+ G + S++EE+ A + +T + P+ +
Sbjct: 832 KGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSP 891
Query: 919 --EEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT--------------- 961
ATP Q P + R ++ ++ + + ++E +P T
Sbjct: 892 AGPAATPAQAQAASTP---RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMP 948
Query: 962 GGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQG--KVVGQTTP 1019
+ A A +E + S KK+ +V + + P TQ KV+ Q
Sbjct: 949 TAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKAS 1008
Query: 1020 ESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPV 1079
E+ + S V T A S + QA + + P E +T
Sbjct: 1009 EAQPPVARTQPSSGVDSAVGTLPA------TSPQSTSVQAKGTNKLRKPKLPEVQQATKA 1062
Query: 1080 ADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQS 1139
+ D E+ E G +S T P++ E EET +S
Sbjct: 1063 PESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTE--------TLVEETAAES 1114
Query: 1140 KMEDTL 1145
+D +
Sbjct: 1115 SEDDVV 1120
Score = 60.8 bits (146), Expect = 1e-08
Identities = 252/1348 (18%), Positives = 466/1348 (34%), Gaps = 196/1348 (14%)
Query: 401 EVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQ 460
EV+ S Q+ Q L ++T G+K+K + + P + +S
Sbjct: 29 EVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESS 88
Query: 461 EEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEK--KREGVTPWASFKKM 518
EE++ E+ A + + + + +E A ++ EK K P + K
Sbjct: 89 EEEE-EAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKT 147
Query: 519 VTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTS 578
V + P KSA S+ + SE +EE GSV +
Sbjct: 148 VANLLSGKSPR-----------KSAEPSANTTLVSETEEE--GSVP----------AFGA 184
Query: 579 VSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHD 638
+ ++ G + + SSS +E + + A GT G G+
Sbjct: 185 AAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPG--KGATPAP 242
Query: 639 PGQGSS--SPEQAGSPTEGEGVSTWESF-KRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 695
PG+ + S +AG P E S+ ES TP K+ + + + S G+
Sbjct: 243 PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA----- 297
Query: 696 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 755
+ P KE R+ P + P G E+DS S +
Sbjct: 298 --SAPAKESP----------RKGAAPAPPGKTGPAVAKAQAGKREEDSQ-------SSSE 338
Query: 756 AVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSW 815
+ E+ QA+ S + P+ +AA+ +KE AA A +
Sbjct: 339 ESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRK-----GAAPAPPRKTGP--------- 384
Query: 816 ISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTP 875
+A+ + +Q E + E +RE +A V +PL ++ + + + + L
Sbjct: 385 -AAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQV-KPLGKSPQVKPASTMGMGPL-- 440
Query: 876 EAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIE 935
+ AGP+ + A+ + + + DS ++EE++ + E
Sbjct: 441 -----GKGAGPVPPGKVGPATPSAQVGKWEE------DSESSSEESSDSSDGEVPTAVAP 489
Query: 936 EQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVV 995
QE+ +LQA + + P G P+ + +AE+P + +E+S ++ +D
Sbjct: 490 AQEKSLGNILQA------KPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESS--EESSDSA 541
Query: 996 LKVDAQEAKTEPFTQGKV-VGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEM 1054
+A A T + + + QT ++ K T S + + + QA AG +
Sbjct: 542 DSEEAPAAMTAAQAKPALKIPQT--KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 599
Query: 1055 VMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAE 1114
A+ + P + + ++ + G V + + V G Q +A
Sbjct: 600 GSSPAVA-GGTQRPAEDSSSSEESDSEEEKTGLA-----VTVGQAKSVGKGLQ---VKAA 650
Query: 1115 AVPA-----QKERPPAPSSF---VFQEETKEQSKMEDTLEHTD-KEVSVETVSILSKTEG 1165
+VP Q P P V Q + ++Q E + E +D +E + + + +
Sbjct: 651 SVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKK 710
Query: 1166 TQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKV-TEVALKGEGTEEAECKKDDALEL 1224
TQ A + G + T ++++ ++V + + +
Sbjct: 711 TQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASV 770
Query: 1225 QSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPI 1284
S K+ + + + + + +E E ++ + E ET V ++ P
Sbjct: 771 PSVGKAVATAAQAQTGPEEDSGSSEEE----SDSEEEAETLAQVKPSGKTHQIRAALAPA 826
Query: 1285 IDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSS---------EASFTLTAAAE-EEKVLG 1334
+ ++ ++ +PP G A K S EA +T+A + ++
Sbjct: 827 KESPRKGAA--PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIF 884
Query: 1335 ETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPG-----EDAVP----------TGP 1379
N G PA A + + +E A ED +P T
Sbjct: 885 VDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNV 944
Query: 1380 DCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPEN 1439
+ P I + G SS E + + K + E A Q K + A L +
Sbjct: 945 VTMPTAHPRIAPKASMAGASSSKESSRISDGKKQ-----EGPATQVSKKNPASLPLT-QA 998
Query: 1440 GILELETKSSKLVQNIIQT----AVDQFVRTEETATEMLTS------------ELQTQAH 1483
+ L K+S+ + +T VD V T + TS +L
Sbjct: 999 ALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQ 1058
Query: 1484 VIKA--------DSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKD 1535
KA DS D+ +E++GE PQ + T + +E T V + ++ S+D
Sbjct: 1059 ATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTE-TLVEETAAESSED 1117
Query: 1536 MSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLV 1595
A +++ L + P +K+ P+ D ++ S +
Sbjct: 1118 DVVAPSQSL-------------LSGYMTPGLTPANSQASKATPKLDSSPSVS-----STL 1159
Query: 1596 EPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHS 1655
K+D G P+ L + +GG S T +K K+ A + + S
Sbjct: 1160 AAKDDPDGKQEAKPQQAAGML--SPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQS 1217
Query: 1656 ESDKAITPQAQEELQKQERESAKSELTE 1683
+ + Q + Q + S LTE
Sbjct: 1218 NITQCLLGQPWPLNEAQVQASVVKVLTE 1245
Score = 59.3 bits (142), Expect = 3e-08
Identities = 231/1164 (19%), Positives = 403/1164 (34%), Gaps = 189/1164 (16%)
Query: 118 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEK 177
K +GA A +KES K + P + A+ E Q+ E + +E+
Sbjct: 290 KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQS----SSEESDSEEE 345
Query: 178 EPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKV 237
P+++ S +P + K+ +G A + + + +V E+ E+
Sbjct: 346 APAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES 405
Query: 238 DTEEDGKAEVASEKLTASEQAHPQEPAE---------------------SAHEPRLSAEY 276
D++ + A + + ++ ++ +PA + ++
Sbjct: 406 DSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWE 465
Query: 277 EKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAE--------VHVSTVEE 328
E E SEE S G AP + ++ A+ V V E
Sbjct: 466 EDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 525
Query: 329 RTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSP-- 386
+ + EE++ S +EE Q A+PA ++ + K C + T A ++P
Sbjct: 526 KPMDNSESSEESSDSADSEEAPAAMTAAQ-AKPALKIPQTK-ACPKKTNTTASAKVAPVR 583
Query: 387 -----DEKV----------------LSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTST 425
K +P E S E S +E+ + + +
Sbjct: 584 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 643
Query: 426 GLK-KLSGKKQKGKRGGG------DEESGEHTQVPA----DSPDSQEEQKGESSASSPEE 474
GL+ K + KG G G + TQV A DS S+EE E +A+SP +
Sbjct: 644 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 703
Query: 475 PEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKR--VRRPSESD 532
+ T ++K A+ A + VT A K+ K + VR P S
Sbjct: 704 VK--TSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNST 761
Query: 533 KEDELDKVKSATLSSTESTASEMQ---EEMKGSVEEPKPEEPKRKVDTSV-----SWEAL 584
++ +TA++ Q EE GS EE E + + V + +
Sbjct: 762 VLAR-GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIR 820
Query: 585 ICVGSSKKRARRGSSSDEEG--GPKAMGGDHQKADEAGKDKETGTDGILAGSQEH----- 637
+ +K+ R+G++ G GP A Q D +E+ +DG +
Sbjct: 821 AALAPAKESPRKGAAPTPPGKTGPSAAQAGKQD-DSGSSSEESDSDGEAPAAVTSAQVIK 879
Query: 638 ------DPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 691
DP + + P A +P + + ST + + + S S +SED
Sbjct: 880 PPLIFVDPNRSPAGP--AATPAQAQAASTPRKARASESTARSSSS----ESEDEDVIPAT 933
Query: 692 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDA----GPTGANEDDSDVPA 747
+ TP + + P +E + + D GP A + PA
Sbjct: 934 QCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGP--ATQVSKKNPA 991
Query: 748 VVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATI 807
+PL+ Q A K Q +A V++ S V + + +T
Sbjct: 992 SLPLT------------QAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTS 1039
Query: 808 IEERSPSWISASVTEPLEQV--EAEAALLTEEVLEREVIAEEE---------PPTVTEPL 856
++ + + + ++Q E++ +E+ + +EE+ T+ P
Sbjct: 1040 VQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPT 1099
Query: 857 PENREARGDTVVSE--AELTPEAVTAAE--------TAGPLGA-EEGTEASAAEETTEMV 905
P +R +T+V E AE + + V A T G A + ++A+ +++ V
Sbjct: 1100 P----SRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSV 1155
Query: 906 SAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPE 965
S+ D PD +EA P Q P +E + Q K G G P+
Sbjct: 1156 SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQ------KSRKPKKGAGNPQ 1209
Query: 966 --------DVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQT 1017
++ Q + E Q +AS +K T+++ QE K KVV T
Sbjct: 1210 ASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELL----EQERK-------KVV-DT 1257
Query: 1018 TPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVM----EQAIPPDSVETPTDSET 1073
T ES K + + S + A T K +++ E ++ P+ +T T S+
Sbjct: 1258 TKESSRKGWESRKRKLSGDQPA---ARTPRSKKKKKLGAGEGGEASVSPE--KTSTTSKG 1312
Query: 1074 DGSTPVADFDAPGTTQKDEI------VEIHEENEVASGTQSGGTEAEAVPAQKERPPAPS 1127
A D K + E EE + GT GG ++ P K+
Sbjct: 1313 KAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSN--PKSKKEKKKSD 1370
Query: 1128 SFVFQEETKEQSKMEDTLEHTDKE 1151
+E KE+ K D E
Sbjct: 1371 KRKKDKEKKEKKKKAKKASTKDSE 1394
Score = 35.4 bits (80), Expect = 0.47
Identities = 29/140 (20%), Positives = 57/140 (40%), Gaps = 17/140 (12%)
Query: 118 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEE-CKEEGEEKQE 176
K LGAGE P++++ + KR+++ ++ G + K+E EE+ +
Sbjct: 1287 KKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ 1346
Query: 177 KEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEK 236
K S S+ ++K K K+D+ + +KKK ++
Sbjct: 1347 KGMGTVEGGDQSNPKSK----------------KEKKKSDKRKKDKEKKEKKKKAKKAST 1390
Query: 237 VDTEEDGKAEVASEKLTASE 256
D+E + + +K TA +
Sbjct: 1391 KDSESPSQKKKKKKKKTAEQ 1410
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 98.2 bits (243), Expect = 6e-20
Identities = 308/1574 (19%), Positives = 558/1574 (35%), Gaps = 246/1574 (15%)
Query: 209 WRKKTSF-RKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESA 267
W++ + RK K +E A + KK + + + T E + E +E TA +A P+ S
Sbjct: 53 WQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETA--KATPR--LAST 108
Query: 268 HEPRLSAEYE---KVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVS 324
+ L A+ K + +E + +G G S PA T + ++ + +
Sbjct: 109 NSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
Query: 325 TVEERTEE------------------QKTEVEETAGSVPAEELVEMDAEPQEAEPAKELV 366
V E EE Q E S E VE + A+ V
Sbjct: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV 228
Query: 367 KLKETCVSGEDPTQG--ADLSPDEKVLSKPP---------------EGVVSEVEM-LSSQ 408
KE+ P G D++P K + PP EG SE E ++
Sbjct: 229 STKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTR 288
Query: 409 ERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESS 468
++K L+ S K GK G G+ V + + + E+ ESS
Sbjct: 289 SQVKASEKILQVRAASAPAKGTPGK------GATPAPPGKAGAVASQTKAGKPEEDSESS 342
Query: 469 ASSPEEPEEITCLEKGLAEVQQDGEAEE-GATSDGEKK--REGVTPWASFKKMVTPKKRV 525
+ + EE T K L + + G+ + GA S K+ R+G P K K
Sbjct: 343 SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQ 402
Query: 526 RRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWE--- 582
E D + ++ S + ++ S +++ + P E P++ + +
Sbjct: 403 AGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA-SAPAKESPRKGAAPAPPRKTGP 461
Query: 583 --ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPG 640
A + VG ++ +R S + + + GK + + G G
Sbjct: 462 AAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM-GMGPLGKG 520
Query: 641 QGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDT-E 699
G P + G T V WE + S+S EE S+ S + P
Sbjct: 521 AGPVPPGKVGPATPSAQVGKWE---------EDSESSSEESSDSS------DGEVPTAVA 565
Query: 700 PGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVER 759
P +E+S +I + +P + P + AGP V A P+ ++ E
Sbjct: 566 PAQEKSLGNILQ-------AKPTSSPAKGPPQKAGPVAVQ-----VKAEKPMDNSESSEE 613
Query: 760 EK-----------MEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATII 808
M A QA+ + + P+ KA + + + ++V + +A T
Sbjct: 614 SSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT 673
Query: 809 EERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVV 868
SP+ S +V ++ +++ E +EEE + + + + V
Sbjct: 674 ---SPAGSSPAVAGGTQRPAEDSSS------SEESDSEEEKTGLAVTVGQAKSVGKGLQV 724
Query: 869 SEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVE 928
A + + TA L + G T V A Q + +++EE + +E
Sbjct: 725 KAASVPVKGSLGQGTAPVLPGKTGP-------TVTQVKAEKQ--EDSESSEEESDSEEAA 775
Query: 929 GGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT-GGPEDVLQPVQRAEAERPEEQAEASG 987
++ ++TQ A + GT P V+ +A+ P +
Sbjct: 776 ASPAQVKTSVKKTQAKANPAAARAPSAK---GTISAPGKVVTAAAQAKQRSPSKVKPPVR 832
Query: 988 LKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLA 1047
+ + V+ + A QT PE E + E +S E +AETLA
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPE--EDSGSSEEESDSEE-----EAETLA 885
Query: 1048 GVKSQEMV--MEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASG 1105
VK + A+ P +S G+ P PG T +++ +S
Sbjct: 886 QVKPSGKTHQIRAALAPAK-----ESPRKGAAPTP----PGKTGPSAAQAGKQDDSGSSS 936
Query: 1106 TQS---GGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK 1162
+S G A AQ +PP +F + + + T + T
Sbjct: 937 EESDSDGEAPAAVTSAQVIKPP----LIFVDPNRSPAGPAATPAQAQ---AASTPRKARA 989
Query: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKG---------EGTEE 1213
+E T + E +P + L I T + +A K E +
Sbjct: 990 SESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRI 1049
Query: 1214 AECKKDDALELQSHAKSPPS-PVEREMVVQVEREKTEAEPTHVNEEKLEH-ETAVTVSEE 1271
++ KK + Q K+P S P+ + + + ++ +EA+P + ++AV
Sbjct: 1050 SDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPA 1109
Query: 1272 VSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEK 1331
S Q AK + L P + ++A SE S ++ +EE+
Sbjct: 1110 TSPQSTSVQ-------AKGTNKLRKPKLPEV--QQATKAPESSDDSEDSSDSSSGSEED- 1159
Query: 1332 VLGETANILETGETL--EPAGAHLVLEEKSSEKNEDFAAHPGEDAVP-------TGPDCQ 1382
GE ++ TL P+ ++EE ++E +ED P + + T + Q
Sbjct: 1160 --GEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQ 1217
Query: 1383 A-KSTPVIVSA---TTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIE-DLEP 1437
A K+TP + S+ ++ D +G++ + + + + +E + +P
Sbjct: 1218 ASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKP 1277
Query: 1438 ENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETE 1497
+ G + + L NI Q + Q +E Q QA V+K ++ QE +
Sbjct: 1278 KKGAGNPQASTLALQSNITQCLLGQ---------PWPLNEAQVQASVVKVLTELLEQERK 1328
Query: 1498 KEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMS-----EAS---EKTMTVEVE 1549
K + + S++ K + A S K + EAS EKT T +
Sbjct: 1329 KVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTS-K 1387
Query: 1550 GSTVNDQQLEEVVLPSEEEGGGA----GTKSVPEDDGHALLAERIEKSLVEPKEDEKGDD 1605
G D+ +V E++G G+ G K PE E ++K + +G D
Sbjct: 1388 GKAKRDKASGDV---KEKKGKGSLGSQGAKDEPE--------EELQKGM----GTVEGGD 1432
Query: 1606 VDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQA 1665
+P+++ K+K+K D ++ + ++ + ++ KA T +
Sbjct: 1433 QSNPKSK-----------------------KEKKKSDKRKKDKEKKEKKKKAKKASTKDS 1469
Query: 1666 QEELQKQERESAKS 1679
+ QK++++ K+
Sbjct: 1470 ESPSQKKKKKKKKT 1483
Score = 63.9 bits (154), Expect = 1e-09
Identities = 252/1309 (19%), Positives = 440/1309 (33%), Gaps = 185/1309 (14%)
Query: 401 EVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQ 460
EV+ S Q+ Q L ++T G+K+K + + P + +S
Sbjct: 29 EVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESS 88
Query: 461 EEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEK--KREGVTPWASFKKM 518
EE++ E+ A + + + + +E A ++ EK K P + K
Sbjct: 89 EEEE-EAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKT 147
Query: 519 VTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTS 578
V + P KSA S+ + SE +EE GSV +
Sbjct: 148 VANLLSGKSPR-----------KSAEPSANTTLVSETEEE--GSV----------PAFGA 184
Query: 579 VSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHD 638
+ ++ G + + SSS +E D GK + +
Sbjct: 185 AAKPGMVSAGQADSSSEDTSSSSDE------------TDVEGK------PSVKPAQVKAS 226
Query: 639 PGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDT 698
SP + +P G+ K P K K EE+SE S GS E P
Sbjct: 227 SVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAP-- 284
Query: 699 EPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVE 758
G + +K + R P A P A S A P + ++
Sbjct: 285 -AGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSS 343
Query: 759 REKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISA 818
E ++++ E P KA + SQV +A + R P
Sbjct: 344 EESSDSEE-----ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA--APAPPGKTGP 396
Query: 819 SVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEP---LPENREARGDTVVS----EA 871
+V + E + + E E +EEE P +P P+ R A S A
Sbjct: 397 AVAKAQAGKREEDSQSSSE----ESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA 452
Query: 872 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 931
P A +G +E S++EE+ A++ + + P+ G
Sbjct: 453 PAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAM-----NAAQVKPL----GKS 503
Query: 932 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKE 991
P ++ L A V PG GP V + E E E +E S +
Sbjct: 504 PQVKPASTMGMGPLGKGAGPVP-----PGKVGPATPSAQVGKWE-EDSESSSEESSDSSD 557
Query: 992 TDVVLKV-DAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQA--ETLAG 1048
+V V AQE Q K +KA V +++ + + ++ E+
Sbjct: 558 GEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS 617
Query: 1049 VKSQE----MVMEQAIP----PDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEEN 1100
S+E M QA P P + P + T S VA V
Sbjct: 618 ADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR----------VGTQAPR 667
Query: 1101 EVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSIL 1160
+ + T G+ + AV +RP SS + E+S E+ E T V+V +
Sbjct: 668 KAGTATSPAGS-SPAVAGGTQRPAEDSS------SSEESDSEE--EKTGLAVTVGQAKSV 718
Query: 1161 SKTEGTQEADQYADEKTKDVPFFEGLEGSIDTG---ITVSREKVTEVALKGEGTEEAECK 1217
K G Q K VP ++GS+ G + + T +K E E++E
Sbjct: 719 GK--GLQ-------VKAASVP----VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESS 765
Query: 1218 KDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETA-----VTVSEEV 1272
++++ + + A SP ++ V++ + +A P + + VT + +
Sbjct: 766 EEES-DSEEAAASP-----AQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA 819
Query: 1273 SKQLLQTVNVPIIDGAKEVSSLEG-SPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEK 1331
++ V P+ + G + P +G+ A + Q E S + ++ E+
Sbjct: 820 KQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEE 879
Query: 1332 VLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVS 1391
A + +G+T + A +E P + A PT P K+ P
Sbjct: 880 EAETLAQVKPSGKTHQIRAALAPAKES-----------PRKGAAPTPP---GKTGPSAAQ 925
Query: 1392 A-----TTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1446
A + SD +GE ++ + + + + S A P
Sbjct: 926 AGKQDDSGSSSEESDSDGEAPAAVT-SAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP 984
Query: 1447 KSSKLVQNIIQTAVDQFVRTEE-TATEMLTSELQTQ------AHV-IKADSQDAGQETEK 1498
+ ++ ++ +++ + + AT+ LT ++T AH I + AG + K
Sbjct: 985 RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSK 1044
Query: 1499 EGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQL 1558
E + E P T +++ + S +++A+ K + + + Q
Sbjct: 1045 ESSRISDGKKQEGPATQVSKKNPA----------SLPLTQAALKVLAQKASEA----QPP 1090
Query: 1559 EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALAD 1618
PS GT ++ A+ K L +PK E PE+ + +
Sbjct: 1091 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNK-LRKPKLPEVQQATKAPESSDDSEDS 1149
Query: 1619 TDASGGLTKESPDTNGPKQKE----KEDAQEVELQEGKVHSESDKAITP 1663
+D+S G ++ G K E ++E S D + P
Sbjct: 1150 SDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAP 1198
Score = 59.7 bits (143), Expect = 2e-08
Identities = 236/1166 (20%), Positives = 407/1166 (34%), Gaps = 194/1166 (16%)
Query: 118 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEK 177
K +GA A +KES K + P + A+ E Q+ E + +E+
Sbjct: 367 KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQS----SSEESDSEEE 422
Query: 178 EPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKV 237
P+++ S +P + K+ +G A + + + +V E+ E+
Sbjct: 423 APAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES 482
Query: 238 DTEEDGKAEVASEKLTASEQAHPQEPAE---------------------SAHEPRLSAEY 276
D++ + A + + ++ ++ +PA + ++
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWE 542
Query: 277 EKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAE--------VHVSTVEE 328
E E SEE S G AP + ++ A+ V V E
Sbjct: 543 EDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 602
Query: 329 RTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSP-- 386
+ + EE++ S +EE Q A+PA ++ + K C + T A ++P
Sbjct: 603 KPMDNSESSEESSDSADSEEAPAAMTAAQ-AKPALKIPQTK-ACPKKTNTTASAKVAPVR 660
Query: 387 -----DEKV----------------LSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTST 425
K +P E S E S +E+ + + +
Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
Query: 426 GLK-KLSGKKQKGKRGGG------DEESGEHTQVPA----DSPDSQEEQKGESSASSPEE 474
GL+ K + KG G G + TQV A DS S+EE E +A+SP +
Sbjct: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
Query: 475 PEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKR--VRRPSESD 532
+ T ++K A+ A + VT A K+ K + VR P S
Sbjct: 781 VK--TSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNST 838
Query: 533 KEDELDKVKSATLSSTESTASEMQ---EEMKGSVEEPKPEEPKRKVDTSV-----SWEAL 584
++ +TA++ Q EE GS EE E + + V + +
Sbjct: 839 VLAR-GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIR 897
Query: 585 ICVGSSKKRARRGSSSDEEG--GPKAMGGDHQKADEAGKDKETGTDGILAGSQEH----- 637
+ +K+ R+G++ G GP A Q D +E+ +DG +
Sbjct: 898 AALAPAKESPRKGAAPTPPGKTGPSAAQAGKQD-DSGSSSEESDSDGEAPAAVTSAQVIK 956
Query: 638 ------DPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 691
DP + + P A +P + + S TPRK S E + S + S
Sbjct: 957 PPLIFVDPNRSPAGP--AATPAQAQAAS---------TPRKARAS--ESTARSSSSESED 1003
Query: 692 EHSTPDTE---PGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAV 748
E P T+ PG + V++ P AP ++++ S +
Sbjct: 1004 EDVIPATQCLTPGIRTNVVTM-----------PTAHPRIAPKASMAGASSSKESSRIS-- 1050
Query: 749 VPLSEYDAVEREKMEAQQAQKS-AEQPEQKAATEV-SKELSESQVHMMAAAVADGTRAAT 806
D ++E Q ++K+ A P +AA +V +++ SE+Q + + G +A
Sbjct: 1051 ------DGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAV 1104
Query: 807 -IIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGD 865
+ SP S V+A+ L + + E + T ++ E D
Sbjct: 1105 GTLPATSPQSTS---------VQAKGT----NKLRKPKLPEVQQATKAPESSDDSEDSSD 1151
Query: 866 TVVSEAE--LTPEAVTAAETAGPLGAEEGT--EASAAEETTEMVSAVSQLTDSPDTTEEA 921
+ E P+ +A T GP + T E +AAE + + V A SQ S T
Sbjct: 1152 SSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGL 1211
Query: 922 TPV-QEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQ--------LPGTGGPEDV--LQP 970
TP + P ++ + + K+E++ P TGG E P
Sbjct: 1212 TPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTP 1271
Query: 971 VQRAEAERPEEQAEASGLKKETDVV------------LKVDAQEAK--TEPFTQ-GKVVG 1015
+ + ++ +AS L ++++ +V A K TE Q K V
Sbjct: 1272 QKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVV 1331
Query: 1016 QTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVM----EQAIPPDSVETPTDS 1071
TT ES K + + S + A T K +++ E ++ P+ +T T S
Sbjct: 1332 DTTKESSRKGWESRKRKLSGDQPA---ARTPRSKKKKKLGAGEGGEASVSPE--KTSTTS 1386
Query: 1072 ETDGSTPVADFDAPGTTQKDEI------VEIHEENEVASGTQSGGTEAEAVPAQKERPPA 1125
+ A D K + E EE + GT GG ++ P K+
Sbjct: 1387 KGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSN--PKSKKEKKK 1444
Query: 1126 PSSFVFQEETKEQSKMEDTLEHTDKE 1151
+E KE+ K D E
Sbjct: 1445 SDKRKKDKEKKEKKKKAKKASTKDSE 1470
Score = 35.4 bits (80), Expect = 0.47
Identities = 29/140 (20%), Positives = 57/140 (40%), Gaps = 17/140 (12%)
Query: 118 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEE-CKEEGEEKQE 176
K LGAGE P++++ + KR+++ ++ G + K+E EE+ +
Sbjct: 1363 KKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ 1422
Query: 177 KEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEK 236
K S S+ ++K K K+D+ + +KKK ++
Sbjct: 1423 KGMGTVEGGDQSNPKSK----------------KEKKKSDKRKKDKEKKEKKKKAKKAST 1466
Query: 237 VDTEEDGKAEVASEKLTASE 256
D+E + + +K TA +
Sbjct: 1467 KDSESPSQKKKKKKKKTAEQ 1486
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 93.6 bits (231), Expect = 1e-18
Identities = 267/1269 (21%), Positives = 450/1269 (35%), Gaps = 142/1269 (11%)
Query: 135 KQSTEKPEETLKR-EQSHAEISPPAESGQAVEECKEEGEEKQEK--EPSKSAESPTSPVT 191
K EK E+T +R E+ +++ E + + K QE+ E A V
Sbjct: 9183 KPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVI 9242
Query: 192 SETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDT--EEDGKAEVAS 249
SE F + + + E+++ + K+ + P KV E+ EVA
Sbjct: 9243 SEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAP 9302
Query: 250 EKLTASEQAH-------PQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLA 302
+ + P++P +P + E P +V P E+ P P+A
Sbjct: 9303 VPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVA 9362
Query: 303 T--EVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAE 360
E K+ Q+ VV E ++ V +R E V E EE + + +E
Sbjct: 9363 KKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVP 9422
Query: 361 PAKELVKLKETCVSGED---PTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSP 417
P ++ L + V E P A +P PP VS+ ++ +E+ V
Sbjct: 9423 PPPKVPALPKKPVPEEKVAVPVPVAKKAP-------PPRAEVSKKTVV--EEKRFVAEEK 9473
Query: 418 LKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEE 477
L + + +EE G V + +EE+ + EEPEE
Sbjct: 9474 LSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEE 9533
Query: 478 ITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDEL 537
EK L + + EAE ++ ++K+ + P K P +V E+ K+
Sbjct: 9534 YVVEEK-LHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKV---PEAPKKIVP 9589
Query: 538 DKVKSATLSSTESTASEMQEEMKGSVEEPK-PEEPKRKVDTSVSWEALICVGSSKKRARR 596
+K A + E V PK PEEPK+ V +K+
Sbjct: 9590 EKKVPAPVPKKEK------------VPPPKVPEEPKKPVP--------------EKKVPP 9623
Query: 597 GSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGE 656
EE P + H + + K +L + + +P +A P E +
Sbjct: 9624 KVIKMEEPLPAKVTERHMQITQEEK--------VLVAVTKKE------APPKARVPEEPK 9669
Query: 657 GVSTWESFKRLVTPRKKSK-SKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPG 715
E +L R++ +K+ E + + V P EP IK+
Sbjct: 9670 RAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQP------IKEVTIM 9723
Query: 716 RRKKRPDGKQEQAPV---EDAGPTGANEDDSDVPAVVPLSEYDAVER-EKMEAQQAQKSA 771
K+R +E+A E+ D + P EYD E E+ E ++ ++
Sbjct: 9724 EEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHE 9783
Query: 772 EQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEA 831
E + K + E V A + EE+ P I + P +V E
Sbjct: 9784 EYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEP 9843
Query: 832 ALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEE 891
+ EE + R I + E VTEP ++ + P+ V A E E
Sbjct: 9844 KKVFEEKI-RISITKREKEQVTEP------------AAKVPMKPKRVVAEEKVPVPRKEV 9890
Query: 892 GTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK 951
E E+ + T E V+E E + + EE+ +EV+ + K
Sbjct: 9891 APPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHE-EEEFITEEEVVPVIPVK 9949
Query: 952 VKEESQLPGTGGPEDVLQPVQRAEA--------ERPEEQAEASGLKKETDVVLKVDAQEA 1003
V E + P + V P ++ ++PEE+ KKE KV E
Sbjct: 9950 VPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVP--EV 10007
Query: 1004 KTEPFTQGKVVGQTTPESFE----KAPQVTES-IESSELVTTCQAETLAGVKSQEMVMEQ 1058
+P + KV P+ E K P+V + + ++ + A V ++
Sbjct: 10008 PKKPVPEEKVP-VPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKK 10066
Query: 1059 AIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEI-VEIHEENEVASGTQSGGTEAEAVP 1117
IP + TP + + P P + + V + +E EV E E VP
Sbjct: 10067 LIPEEKKPTPVPKKVEAPPP----KVPKKREPVPVPVALPQEEEVLF-------EEEIVP 10115
Query: 1118 AQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKT 1177
++ P E +E E+ + ++EV E I + E ++Y E+
Sbjct: 10116 EEEVLP----------EEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEE 10165
Query: 1178 KDVPFFEGL-----EGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPP 1232
+ VP E L + + + ++KVTE + EEA K + + K
Sbjct: 10166 EFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRII 10225
Query: 1233 SPVEREMVVQVEREKTEAEPTHVNEEKLEHET-AVTVSEEVSKQLLQTVNVPIIDGAKEV 1291
P E E++ E+ E EP ++EE++ E ++ EEV+ + V + A
Sbjct: 10226 LPKEEEVLPVEVTEEPEEEP--ISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTP 10283
Query: 1292 SSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGA 1351
+ PP ++ K+ V + E K + E ++ E + PA
Sbjct: 10284 VPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKG 10343
Query: 1352 HLVLEEKSS 1360
VLEEK S
Sbjct: 10344 RTVLEEKVS 10352
Score = 89.7 bits (221), Expect = 2e-17
Identities = 295/1525 (19%), Positives = 547/1525 (35%), Gaps = 212/1525 (13%)
Query: 119 DPSLGAGEAASKESEPKQSTEKPEETL--KREQSHAEISPPAESGQA------VEECKEE 170
D S A E K+ +K +E + K++ H E ES + VE E
Sbjct: 9029 DVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEP 9088
Query: 171 GEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKK 230
E+ +EP + E E +++ F +G + ++ + + +E+ EA ++++
Sbjct: 9089 FEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQERE 9148
Query: 231 EQEPEKVDTEEDGK----AEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQ 286
+ +K EE + A+V +K + + E + E EKV++ +
Sbjct: 9149 VIQVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPE 9208
Query: 287 VSGSQGPSEEKPAPLATEVFDEKIE-VHQEE-VVAEVHVSTVEERTEEQKTEVEETAGSV 344
VS P + P+ EV + K+ VH ++ V++E + EE V E +
Sbjct: 9209 VSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEI 9268
Query: 345 PAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEM 404
EE + + A + EP ++ +L E P + A + +KV +PP V EV
Sbjct: 9269 VTEEKIHV-AISKRVEPPPKVPELPEKPA----PEEVAPVPIPKKV--EPPAPKVPEVPK 9321
Query: 405 LSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQK 464
E K P K+ + ++ K VP + +K
Sbjct: 9322 KPVPEEKKPVPVPKKEPAAPPKVPEVPKKP-----------------VPEEKIPVPVAKK 9364
Query: 465 GESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKR--EGVTPWASFKKMVTPK 522
E+ + E ++ E+ + V Q E+ A + KK+ E P ++ V P
Sbjct: 9365 KEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPP 9424
Query: 523 KRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWE 582
+V P+ K +KV + + + E K +V E K + K+ +V
Sbjct: 9425 PKV--PALPKKPVPEEKV-AVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQR 9481
Query: 583 ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQG 642
+ S +EEG ++ + ++ +E ++ E ++ +E+ +
Sbjct: 9482 VEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEE--EEAEVTEYEVMEEPEEYVVEE- 9538
Query: 643 SSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGK 702
E E E ++ + + K +K+EE + P+
Sbjct: 9539 --KLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKV---------PEAP--- 9584
Query: 703 EESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKM 762
KK +P ++ P K+E+ P P VP V +K+
Sbjct: 9585 -------KKIVPEKKVPAPVPKKEKVP----------------PPKVPEEPKKPVPEKKV 9621
Query: 763 EAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTE 822
+ + E+P TE ++++ + ++A + A + EE + V +
Sbjct: 9622 PPKVIKM--EEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLK 9679
Query: 823 PLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAE 882
+ E E E +R + +EE ++ P E + + T++ E E A T E
Sbjct: 9680 LKPKREEEPPAKVTEFRKR--VVKEEKVSIEAPKREPQPIKEVTIMEEKE---RAYTLEE 9734
Query: 883 TAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQ 942
A + EE E + E EE P +E + EE E R
Sbjct: 9735 EAVSVQREEEYEEYEEYDYKEF--------------EEYEPTEEYD----QYEEYEEREY 9776
Query: 943 EVLQAVAEKVKE-ESQLPGTGGPEDVLQPVQRAEAER------PEEQAEASGLKKETDVV 995
E + E + E E +P PE+ + +A + PEE+ KK
Sbjct: 9777 ERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKK----- 9831
Query: 996 LKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMV 1055
LK + EP + FE+ +++ + E VT A+ +K + +V
Sbjct: 9832 LKPPPPKVPEEP-----------KKVFEEKIRISITKREKEQVTEPAAKV--PMKPKRVV 9878
Query: 1056 MEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEA 1115
E+ +P E + PV + P + +E+ E EV + +
Sbjct: 9879 AEEKVPVPRKEV--------APPVRVPEVPKELEPEEVAF---EEEVVTHVEE------- 9920
Query: 1116 VPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADE 1175
++ +EE E+ + ++ ++ E V + + + + E
Sbjct: 9921 -------------YLVEEE-------EEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPE 9960
Query: 1176 KTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPV 1235
+ K VP + E KV EV K E K + + P PV
Sbjct: 9961 EKKPVPVPKKKEAP--------PAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPV 10012
Query: 1236 EREMVVQVEREKTEAEPTHVNEEKL----EHETAVTVSEEVSKQLLQTVNVP--IIDGAK 1289
E V +K EA P V E E + V ++V + VP +I K
Sbjct: 10013 PEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEK 10072
Query: 1290 EVS----SLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGET 1345
+ + +E PP + E V + + E EE+VL E +L E
Sbjct: 10073 KPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEE 10132
Query: 1346 LEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLE-- 1403
+ P ++ EE+ E+ P E+ VP + V+ K + + +
Sbjct: 10133 VLPEEEEVLPEEEEIPPEEE-EVPPEEEYVPEEEEF-VPEEEVLPEVKPKVPVPAPVPEI 10190
Query: 1404 GEKTTSLKWKSDEVDEQVACQEVKVSVAIED----LEPENGILELETKSSKLVQNIIQTA 1459
+K T K + +E + +V +E+ L E +L +E + I +
Sbjct: 10191 KKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEE 10250
Query: 1460 VDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASA-----QDETPIT 1514
+ + + E E+ + VIK +A K+ E P A +++ P+
Sbjct: 10251 IPEEPPSIEEVEEVAPPRV---PEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVP 10307
Query: 1515 SAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQL-----EEVVLPS--EE 1567
K+E+ V + + + +K +G TV ++++ +EVV+ E
Sbjct: 10308 VQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLEL 10367
Query: 1568 EGGGAGTKSVPEDDGHALLAERIEK 1592
E A + +PE++ + E E+
Sbjct: 10368 EVVEAEVEEIPEEEEFHEVEEYFEE 10392
Score = 81.3 bits (199), Expect = 7e-15
Identities = 278/1240 (22%), Positives = 436/1240 (35%), Gaps = 157/1240 (12%)
Query: 130 KESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEK------EPSKSA 183
+E+ Q E+ EE + + E P E EE +E E+ E+ EP K
Sbjct: 9734 EEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPI 9793
Query: 184 ESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDG 243
P PV E T K A K P+E KK + P KV E
Sbjct: 9794 --PVKPVPEEPVPTKPK------APPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPK- 9844
Query: 244 KAEVASEKL----TASEQAHPQEPAESAH-EPRLSAEYEKVELPSEEQVSGSQGPSEEKP 298
+V EK+ T E+ EPA +P+ EKV +P +E + P K
Sbjct: 9845 --KVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKE 9902
Query: 299 APLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQE 358
F+E++ H EE + E + E EE+ EE +P ++ E+ +P
Sbjct: 9903 LEPEEVAFEEEVVTHVEEYLVEEEEEYIHE--EEEFITEEEVVPVIPV-KVPEVPRKPVP 9959
Query: 359 AEPAKELVKLKETCVSGEDPTQGADLSPDEKV------LSKPPEGVVSEVEMLSSQERMK 412
E V K+ + P P+EKV KPP V EV E
Sbjct: 9960 EEKKPVPVPKKKEAPPAKVPE--VPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKV 10017
Query: 413 VQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSP 472
P K + ++ K K+ VP +P E A P
Sbjct: 10018 PVPVPKKVEAPPAKVPEVPKKPVPEKK------------VPVPAPKKVE----APPAKVP 10061
Query: 473 EEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGV-TPWA-------SFKKMVTPKKR 524
E P+++ EK V + EA KKRE V P A F++ + P++
Sbjct: 10062 EVPKKLIPEEKKPTPVPKKVEAPPPKV---PKKREPVPVPVALPQEEEVLFEEEIVPEEE 10118
Query: 525 VRRPSES--DKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEE--PKRKVDTSVS 580
V E +E+E+ + L E E +E P+ EE P+ +V V
Sbjct: 10119 VLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVK 10178
Query: 581 WEALI--CVGSSKKRARRGS---SSDEEGGPKAMGGDHQKADEAG---KDKETGTDGILA 632
+ + V KK+ EE P + +K +E +E +
Sbjct: 10179 PKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVT 10238
Query: 633 GSQEHDPGQGSSSPEQAGSPTEGEGVS---TWESFKRLVTPRKKSKSKLEEKSEDSIAGS 689
E +P PE+ S E E V+ E K+ V K E ++
Sbjct: 10239 EEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKK 10298
Query: 690 GVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVV 749
E P KE +P KK P+ K+ P ++A P + V
Sbjct: 10299 IPEEKVPVPVQKKEAPPAK----VPEVPKKVPE-KKVLVPKKEAVPPAKGRTVLEEKVSV 10353
Query: 750 PLSEYDAVEREKMEAQQAQKSAEQ-PEQKAATEVSKELSESQVHMMAAAVADGTRAATII 808
+ + V +E++E + + E+ PE++ EV + E + H + + +
Sbjct: 10354 AFRQ-EVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIK--LEQHRVE 10410
Query: 809 EERSPSWISASV----TEPLEQVEAEAALLTEEVLEREVIAEEEPPTVT----EPLPENR 860
EE + + E +E E A + ++I ++PPT EP +
Sbjct: 10411 EEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVP 10470
Query: 861 EARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEE 920
E VV E PE T P E E V + P E
Sbjct: 10471 EVPKKIVVEEKVRVPEEPRVPPTKVP---EVLPPKEVVPEKKVPVPPAKKPEAPPPKVPE 10527
Query: 921 ATP--VQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAER 978
A V E + VP ++ E +V + V + E ++P P+ P + EA +
Sbjct: 10528 APKEVVPEKKVPVPPPKKPEVPPTKVPE-VPKAAVPEKKVPEAIPPKPESPPPEVPEAPK 10586
Query: 979 ---PEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESS 1035
PE++ A+ KK V V EA E + KV P K P+V +
Sbjct: 10587 EVVPEKKVPAAPPKKPE--VTPVKVPEAPKEVVPEKKV-----PVPPPKKPEVPPT---- 10635
Query: 1036 ELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDE-IV 1094
+ + V E + +AIPP E+P P F+ P +E
Sbjct: 10636 ------KVPEVPKVAVPEKKVPEAIPP-KPESP---------PPEVFEEPEEVALEEPPA 10679
Query: 1095 EIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1154
E+ EE E A+ Q + VP +K AP + V ++ K+ + + E V
Sbjct: 10680 EVVEEPEPAAPPQVTVPPKKPVPEKK----AP-AVVAKKPELPPVKVPEVPKEVVPEKKV 10734
Query: 1155 ETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEA 1214
V + + K +VP E + + V ++ A E ++
Sbjct: 10735 PLV--------VPKKPEAPPAKVPEVP----KEVVPEKKVAVPKKPEVPPAKVPEVPKKP 10782
Query: 1215 ECKKDDALELQSHAKSPPSPV---EREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEE 1271
++ A+ + A+SPP V E+ + E E +P V EE+ E E E
Sbjct: 10783 VLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEE-EPEVPPPAVPE 10841
Query: 1272 VSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTK 1311
K+++ VP+I + +PPP + E V K
Sbjct: 10842 EPKKIIPEKKVPVIKKPE-------APPPKEPEPEKVIEK 10874
Score = 80.1 bits (196), Expect = 2e-14
Identities = 319/1546 (20%), Positives = 548/1546 (35%), Gaps = 263/1546 (17%)
Query: 133 EPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGE----EKQEKEPSKSAESPTS 188
+P +KP K++++ PPA+ + ++ +E+ +K++ P+K E P
Sbjct: 9956 KPVPEEKKPVPVPKKKEA-----PPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKK 10010
Query: 189 PVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEV- 247
PV E K PK+ VEA K + P+K E+ K V
Sbjct: 10011 PVPEE------------------KVPVPVPKK--VEAPPAKVPEVPKKPVPEK--KVPVP 10048
Query: 248 ASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFD 307
A +K+ A P+ P + E E + +P + + + P + +P P+ +
Sbjct: 10049 APKKVEAPPAKVPEVPKKLIPE-----EKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQ 10103
Query: 308 EKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVK 367
E+ + +EE+V E V EE ++ EV +P EE E+ E +E P +E V
Sbjct: 10104 EEEVLFEEEIVPEEEVLPEEEEVLPEEEEV------LPEEE--EVLPEEEEIPPEEEEVP 10155
Query: 368 LKETCVSGEDPTQGADLSPDEKVLS--KPPEGVVSEVEMLSSQERMKVQGSPLKKLFTST 425
+E V E+ + P+E+VL KP V + V + + K P K+
Sbjct: 10156 PEEEYVPEEE-----EFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPA 10210
Query: 426 GLKKLSGKKQKGKRGGGDEESG---EHTQVPADSPDSQEEQKGESSASSPEEPEEIT--- 479
+ ++ K ++ + EE E T+ P + P S+EE E S EE EE+
Sbjct: 10211 KVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPP--SIEEVEEVAPPR 10268
Query: 480 ---CLEKGLAE----VQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESD 532
++K + E V + EA S +K E P KK P K P +
Sbjct: 10269 VPEVIKKAVPEAPTPVPKKVEAPPAKVS--KKIPEEKVPVPVQKKEAPPAKVPEVPKKVP 10326
Query: 533 KEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKK 592
++ L K A + T E K SV + K +++ V EA + ++
Sbjct: 10327 EKKVLVPKKEAVPPAKGRTVLEE----KVSVAFRQEVVVKERLELEVV-EAEVEEIPEEE 10381
Query: 593 RARRGSSSDEEGG----PKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQ 648
EEG + + + + +E + ++ + ++E + + +P +
Sbjct: 10382 EFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPK 10441
Query: 649 AGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVE-HSTPDTEPGKEESWV 707
P E + + V PRK+ +K+ E + + V P P K +
Sbjct: 10442 G--PEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVL 10499
Query: 708 SIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQA 767
K+ +P ++ P K+ +AP P VP + + V +K+
Sbjct: 10500 PPKEVVPEKKVPVPPAKKPEAP----------------PPKVPEAPKEVVPEKKVPVPPP 10543
Query: 768 QKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQV 827
+K P + EV K A + E++ P I P +V
Sbjct: 10544 KKPEVPPTK--VPEVPK--------------------AAVPEKKVPEAIPPKPESPPPEV 10581
Query: 828 EAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPL 887
+EV+ E++ P PE T V E E V E P+
Sbjct: 10582 PEAP---------KEVVPEKKVPAAPPKKPEV------TPVKVPEAPKEVVP--EKKVPV 10624
Query: 888 GAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQA 947
+ E T P+ + A P ++V +P + E EV +
Sbjct: 10625 PPPKKPEVPP--------------TKVPEVPKVAVPEKKVPEAIPP--KPESPPPEVFEE 10668
Query: 948 VAEKVKEESQLPGTGGPEDVLQPVQRAEAERP--EEQAEASGLKKETDVVLKVDAQEAKT 1005
E EE PE P ++P E++A A KK +KV +
Sbjct: 10669 PEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEV 10728
Query: 1006 EPFTQGKVVGQTTPESFE-KAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDS 1064
P + +V PE+ K P+V + + + V + + K E V ++ + +
Sbjct: 10729 VPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPE-VPKKPVLEEK 10787
Query: 1065 VETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEE-NEVASGTQSGGTEAEAVPAQKERP 1123
P + P E++EE E+A + E + VP +E
Sbjct: 10788 PAVPVPERAESPPP----------------EVYEEPEEIAPEEEIAPEEEKPVPVAEEEE 10831
Query: 1124 PAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYAD---EKTK-- 1178
P EE K K + + V ++ K E + + EK K
Sbjct: 10832 PEVPPPAVPEEPK-------------KIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLK 10878
Query: 1179 -------DVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECK----KDDALELQSH 1227
P E ++ I + ++KV E E E K + +L
Sbjct: 10879 PRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPE 10938
Query: 1228 AKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDG 1287
K P P E ++ V R++ E E V +KLE V E + ++ V VP +
Sbjct: 10939 RK--PEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTV-- 10994
Query: 1288 AKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLE 1347
+E + +V + + L A + K E I E
Sbjct: 10995 --------------TKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPE 11040
Query: 1348 PAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGP-DCQAKSTPVIVSATTKKGLSSDLEGEK 1406
P + K + A E A P GP K TP + A +K L GEK
Sbjct: 11041 PTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAERRK-LRPGSGGEK 11099
Query: 1407 TTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETK---SSKLVQNII--QTAVD 1461
DE ++K +V ++ ++ I+ E++ SS + + ++ TA+
Sbjct: 11100 PP---------DEAPFTYQLK-AVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAIT 11149
Query: 1462 QFVR-----TEETATEMLTSELQTQAHVIKADSQDAGQET------EKEGEEPQASAQDE 1510
+++ E + + H+I DAG+ T KE +E
Sbjct: 11150 TWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEE 11209
Query: 1511 TPITSAK--EESESTAVGQ-----AHSDISKDMSEASEKTMTVEVEGSTVNDQ-QLEEVV 1562
P+ K EE + GQ + +D+ + + VE G V L +
Sbjct: 11210 LPVRFVKTLEEEVTVVKGQPLYLSCELNKERDVVWRKDGKIVVEKPGRIVPGVIGLMRAL 11269
Query: 1563 LPSEEEGGGAGTKSVPEDDGHAL-------LAERIEKSLVEPKEDE 1601
++ + AGT +V ++ + L + E I LV+P D+
Sbjct: 11270 TINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQ 11315
Score = 49.3 bits (116), Expect = 3e-05
Identities = 88/448 (19%), Positives = 178/448 (39%), Gaps = 55/448 (12%)
Query: 4 TITITVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQ--EETPEII----EQIPSSESN 57
T T V + +++ +++++K TK V D + + T E+I EQ+ +
Sbjct: 453 TTTTAVHIQPAQEQVRKEAEKTAVTKVVVAADKAKEQELKSRTKEVITTKQEQMHVTHEQ 512
Query: 58 LEELTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAG---A 114
+ + T+ T I K + + + ++ T+K V ++++ AA
Sbjct: 513 IRKETEKTFVPKVVISAAKAKEQ---ETRISEEITKKQKQVTQEAIRQETEITAASMVVV 569
Query: 115 GDHKDPSLGAGEAASKESEPKQ-----STEK-PEETLKREQSHAEISPPAESGQAVEECK 168
K L A +E+ +Q S EK +ET K ++ P Q +
Sbjct: 570 ATAKSTKLETVPGAQEETTTQQDQMHLSYEKIMKETRKTVVPKVIVATPKVKEQDLVSRG 629
Query: 169 EEG-----------EEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK 217
EG +EK KE K+A S + T++ +++ + +
Sbjct: 630 REGITTKREQVQITQEKMRKEAEKTALSTIAVATAKA---------------KEQETILR 674
Query: 218 PKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYE 277
+E E+ + KVD + KAE + + A +QA +EP E H A+
Sbjct: 675 TRETMATRQEQIQVTHG-KVDVGK--KAEAVATVVAAVDQARVREPREPGHLEESYAQQT 731
Query: 278 KVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEV 337
+E +E++S ++ + V + ++ + +E H+ T +++ +++
Sbjct: 732 TLEYGYKERISAAKVAEPPQRPASEPHVVPKAVKPRVIQAPSETHIKTTDQKGMHISSQI 791
Query: 338 EETAGSVPAEELVEMDAEPQEAEPAKELVKLK--ETCVSGEDPTQGADLSPDEKVLSKPP 395
++T + E LV +D P+ A P + K+ +T E G+ ++ +K LS
Sbjct: 792 KKTT-DLTTERLVHVDKRPRTASPHFTVSKISVPKTEHGYEASIAGSAIATLQKELSATS 850
Query: 396 EG-----VVSEVEMLSSQERMKVQGSPL 418
V + S+ R++ + +PL
Sbjct: 851 SAQKITKSVKAPTVKPSETRVRAEPTPL 878
Score = 47.8 bits (112), Expect = 9e-05
Identities = 120/544 (22%), Positives = 195/544 (35%), Gaps = 101/544 (18%)
Query: 120 PSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEP 179
P + E E+ P + P E + + A PPAE EE + P
Sbjct: 10641 PKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPAEV----------VEEPEPAAP 10690
Query: 180 SKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDT 239
+ P PV + +KP+ V+ E KE PEK
Sbjct: 10691 PQVTVPPKKPVPEKKAPA---------------VVAKKPELPPVKVPEVPKEVVPEK--- 10732
Query: 240 EEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGP-SEEKP 298
V +K A P+ P E E +++ +K E+P + + P EEKP
Sbjct: 10733 ---KVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVP-KKPEVPPAKVPEVPKKPVLEEKP 10788
Query: 299 A-PLATEVFDEKIEVHQ--EEVVAEVHVSTVEER----TEEQKTEVEETAGSVPAEELVE 351
A P+ EV++ EE+ E ++ EE+ EE++ EV A
Sbjct: 10789 AVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPA---------- 10838
Query: 352 MDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPP--------EGVVSEVE 403
+ EP++ P K++ +K+ + + K+ +PP E V ++
Sbjct: 10839 VPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIF 10898
Query: 404 MLSSQERMKVQGSP-LKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEE 462
L + + KV P + + T LK G+K+ K +P P+ +EE
Sbjct: 10899 QLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRK------------LLPERKPEPKEE 10946
Query: 463 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPK 522
+S E EE K L +V++ E E+ ++ T
Sbjct: 10947 VVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEE-----------VEVPTVT 10995
Query: 523 KRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWE 582
KR R+ E K E +K A + + E+K +P P EP+ T ++
Sbjct: 10996 KRERKIPEPTKVPE---IKPAIPLPAPEPKPKPEAEVK--TIKPPPVEPE---PTPIA-- 11045
Query: 583 ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQG 642
A + V K+A + +E P K G K+T + I A ++ PG G
Sbjct: 11046 APVTVPVVGKKAEAKAPKEEAAKP--------KGPIKGVPKKTPSP-IEAERRKLRPGSG 11096
Query: 643 SSSP 646
P
Sbjct: 11097 GEKP 11100
Score = 42.0 bits (97), Expect = 0.005
Identities = 179/912 (19%), Positives = 327/912 (35%), Gaps = 181/912 (19%)
Query: 841 REVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEE 900
R V EE PP V P+P L P T E P E T+ + ++
Sbjct: 8950 RAVPPEEIPPVVAPPIP--------------LLLP---TPEEKKPPPKRIEVTKKAVKKD 8992
Query: 901 TTEMVSAVSQLTDSPDTTEE-ATPVQEVEGGVPDIEEQERRTQEV----------LQAVA 949
++V+ ++T + ++ P + P+I + + +EV +Q
Sbjct: 8993 AKKVVAKPKEMTPREEIVKKPPPPTTLIPAKAPEIIDVSSKAEEVKIMTITRKKEVQKEK 9052
Query: 950 EKVKEESQ---------LPGTGGPEDVL------QPVQRAEAERPEEQAEASGLKKETDV 994
E V E+ Q + P D L +P ++ E P+E E E V
Sbjct: 9053 EAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEPFEQPYYEEPDEDYE------EIKV 9106
Query: 995 VLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEM 1054
K + E E F +G+ + E + E+ + E++ Q + +S E
Sbjct: 9107 EAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVI---QVQKEVYEESHER 9163
Query: 1055 VMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAE 1114
+ +P + P + + + ++E V++ + EV+ +
Sbjct: 9164 KVPAKVP--EKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSK---------K 9212
Query: 1115 AVPAQKERPPAPSSFVFQE----ETKEQSKMEDTL---EHTDKEVSVETVSILSKTEGTQ 1167
VP + R P + + TK+ E+ + HT++EVSV TV + K T+
Sbjct: 9213 IVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSV-TVPEVQKEIVTE 9271
Query: 1168 EADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSH 1227
E A K + P KV E+ K E A +E
Sbjct: 9272 EKIHVAISKRVEPP-----------------PKVPELPEKPAPEEVAPVPIPKKVE---- 9310
Query: 1228 AKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDG 1287
PP+P V +V ++ E V K E V E K + +
Sbjct: 9311 ---PPAP----KVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPE--------- 9354
Query: 1288 AKEVSSLEGSPPPCLGQEEAVCTKI-QVQSSEASFTLTAAAEEEKVLGETANILETGETL 1346
E P P ++EA K+ +VQ EEK+ T +
Sbjct: 9355 -------EKIPVPVAKKKEAPPAKVPEVQK--------GVVTEEKITIVTQREESPPPAV 9399
Query: 1347 EPAGAHLVLEEKS--SEKNEDFAAHPGEDAVPTGPDCQAK-STPVIVSATTKKGLSSDLE 1403
V EE+ K E+ P A+P P + K + PV V+ KK E
Sbjct: 9400 PEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVA---KKAPPPRAE 9456
Query: 1404 GEKTTSLKWKSDEVDEQVAC---QEVKVS---VAIED----LEPENGILELETKSSKLVQ 1453
K T ++ K +E+++ Q V+V+ V+ E+ E E G+ + + +
Sbjct: 9457 VSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGV-SISVYREEERE 9515
Query: 1454 NIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEK----------EGEEP 1503
+ V ++ EE ++ +L + ++A+ + + EK + EEP
Sbjct: 9516 EEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEP 9575
Query: 1504 QASAQDETP--------ITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVE---GST 1552
+ E P + + + E + + K + E +++E +
Sbjct: 9576 PPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAK 9635
Query: 1553 VNDQQL----EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDD 1608
V ++ + EE VL + + VPE+ A+ E++ K ++PK +E+
Sbjct: 9636 VTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLK--LKPKREEE------ 9687
Query: 1609 PENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGK--VHSESDKAITPQAQ 1666
T+ + KE + ++E + +EV + E K ++ ++A++ Q +
Sbjct: 9688 -----PPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQRE 9742
Query: 1667 EELQKQERESAK 1678
EE ++ E K
Sbjct: 9743 EEYEEYEEYDYK 9754
Score = 41.6 bits (96), Expect = 0.007
Identities = 102/479 (21%), Positives = 169/479 (35%), Gaps = 57/479 (11%)
Query: 645 SPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEE--------KSEDSIAGSGVEHS-- 694
SP ++ SP S S + + RK S + K E +A S
Sbjct: 302 SPVRSVSPAARISTSPIRSVRSPLLMRKTQASTVATGPEVPPPWKQEGYVASSSEAEMRE 361
Query: 695 ---TPDTEPGKEESW-----VSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSD-- 744
T T+ EE W V + I G + +A TGA E D
Sbjct: 362 TTLTTSTQIRTEERWEGRYGVQEQVTISGAAGAAASVSASASYAAEAVATGAKEVKQDAD 421
Query: 745 ----VPAVVPLSEYDAVEREKMEA--QQAQKSAEQPE--QKAATEVSKELSESQVHMMAA 796
V VV + V + A Q AQ++ Q A +V KE ++ V +
Sbjct: 422 KSAAVATVVAAVDMARVREPVISAVEQTAQRTTTTAVHIQPAQEQVRKEAEKTAVTKVVV 481
Query: 797 AVADGTRAATIIEERSPSWISAS-----VTEPLEQVEAEAALLTEEVLEREVIAEEEPPT 851
A AD + + + R+ I+ VT + E E + + V+ E+E
Sbjct: 482 A-ADKAKEQEL-KSRTKEVITTKQEQMHVTHEQIRKETEKTFVPKVVISAAKAKEQETRI 539
Query: 852 VTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETT--------- 902
E + ++ + + E E+T ++ TA E T A EETT
Sbjct: 540 SEEITKKQKQVTQEAIRQETEITAASMVVVATAKSTKLE--TVPGAQEETTTQQDQMHLS 597
Query: 903 -EMVSAVSQLTDSPDTTEEATPVQEVE------GGVPDIEEQERRTQEVLQAVAEKVKEE 955
E + ++ T P V+E + G+ EQ + TQE ++ AEK
Sbjct: 598 YEKIMKETRKTVVPKVIVATPKVKEQDLVSRGREGITTKREQVQITQEKMRKEAEKTALS 657
Query: 956 SQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVG 1015
+ T ++ + + R Q + + DV K +A Q +V
Sbjct: 658 TIAVATAKAKE-QETILRTRETMATRQEQIQVTHGKVDVGKKAEAVATVVAAVDQARVRE 716
Query: 1016 QTTPESFEK--APQVTESIESSELVTTCQ-AETLAGVKSQEMVMEQAIPPDSVETPTDS 1071
P E+ A Q T E ++ + AE S+ V+ +A+ P ++ P+++
Sbjct: 717 PREPGHLEESYAQQTTLEYGYKERISAAKVAEPPQRPASEPHVVPKAVKPRVIQAPSET 775
Score = 35.0 bits (79), Expect = 0.62
Identities = 106/496 (21%), Positives = 179/496 (36%), Gaps = 62/496 (12%)
Query: 222 EVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQE-PAESAHEPRLSAEYEKVE 280
E AS + K E+ EE L A P+ R S + +
Sbjct: 32529 EHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEP 32588
Query: 281 LPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEE-------- 332
+P+ + Q S + T + E+ + E + S V E +E
Sbjct: 32589 VPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTL 32648
Query: 333 --QKTEVEETA-GSVPAEELVEMDAEPQEAEPAKELVKLKETC-VSGEDPTQGADLSPDE 388
QK V E A S P + E + EA + + VK E PT+ +P E
Sbjct: 32649 TIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKP-TPTE 32707
Query: 389 KVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGE 448
KV P + L ++ ++ KL L K+ + G +
Sbjct: 32708 KVQHLPVSAPPKITQFLKAEASKEIA-----KLTCVVESSVLRAKEVTWYKDGKKLKENG 32762
Query: 449 HTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREG 508
H Q S D E K + S + E C G EG TS + G
Sbjct: 32763 HFQFHY-SADGTYELKINNLTESDQG--EYVCEISG-----------EGGTSKTNLQFMG 32808
Query: 509 VTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKP 568
+FK + ++V + SE+ K D+ +TEST + E KP
Sbjct: 32809 ----QAFKSI---HEKVSKISETKKSDQ---------KTTESTVTRKTEPKAPEPISSKP 32852
Query: 569 EEPKRKVDTSVSWEALICVG-SSKKRARRGSSSDEEGGPKAMGGDHQKADEAG------K 621
DT+VS +++ + R + ++G GG ++ +++ G
Sbjct: 32853 VIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIH 32912
Query: 622 DKETGTDGILAGSQEHDPGQGSSSPE---QAGSPTEGEGVSTWESFKRLVTPRKKSKSKL 678
+T G+ + ++ G SSS + +A TE + VST ++ + +TP+KK+ +
Sbjct: 32913 KTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSE--ITPQKKAVVQ- 32969
Query: 679 EEKSEDSIAGSGVEHS 694
EE S+ ++ ++ S
Sbjct: 32970 EEISQKALRSEEIKMS 32985
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 89.4 bits (220), Expect = 3e-17
Identities = 149/599 (24%), Positives = 243/599 (40%), Gaps = 57/599 (9%)
Query: 211 KKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTA--SEQAHPQEPAESAH 268
K+T + + +E + +E+ E+E ++ EE+GK E E+ A E+ PAE A
Sbjct: 452 KETVIVEEQTEETQVTEEVTEEEEKEA-KEEEGKEEEGGEEEEAEGGEEETKSPPAEEAA 510
Query: 269 EPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEE 328
P A+ V+ ++ EE +P + ++ +EE + + E+
Sbjct: 511 SPEKEAK-SPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569
Query: 329 RTEEQKTEVE--ETAGSVPAEELVEMDAEPQEAEPAKELVKLK-ETCVSGEDPTQGADLS 385
+ EV+ E A S PA+E + AE + E AK VK + ++ + P + S
Sbjct: 570 EEAKSPAEVKSPEKAKS-PAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKS 628
Query: 386 PDE-----------KVLSKPPEGVVS-EVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGK 433
P E K +K PE S E E S E+ K SP+K S K S
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAK---SPVKAEAKSPE-KAKSPV 684
Query: 434 KQKGKRGGGDEESGEHTQVPADSPDS-----QEEQKGESSASSPEEPEEITCLEKGLAEV 488
K + K E++ + A SP+ +EE K A SP + EE EK + V
Sbjct: 685 KAEAK---SPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVK-EEAKTPEKAKSPV 740
Query: 489 QQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSST 548
+++ ++ E A S + K V S + K+ R P++ E VK + S
Sbjct: 741 KEEAKSPEKAKSPEKAKTLDV---KSPEAKTPAKEEARSPADKFPEKAKSPVKE-EVKSP 796
Query: 549 ESTASEMQEEMKGSVEE-PKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPK 607
E S ++E+ K +E PK EE K V + + K+ ++ PK
Sbjct: 797 EKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEV----KVKEPPKKAEEEKAPATPK 852
Query: 608 AMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRL 667
K +EA K KE + E P+++ + E E K++
Sbjct: 853 TEEKKDSKKEEAPK-KEAPKPKV-----EEKKEPAVEKPKESKVEAKKEEA---EDKKKV 903
Query: 668 VTPRKKSKSKLEEKSE-DSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQE 726
TP K++ +K+E K + + V PD KE S + KK +K D K+E
Sbjct: 904 PTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKK---DTKEE 960
Query: 727 QAPVEDAGP-TGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK 784
+A + P T A + D S+ A + EK + QK ++ PE+ + +K
Sbjct: 961 KAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTD-QKDSKPPEKATEDKAAK 1018
Score = 89.0 bits (219), Expect = 4e-17
Identities = 133/602 (22%), Positives = 221/602 (36%), Gaps = 70/602 (11%)
Query: 433 KKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDG 492
+K+ + G +EE GE +E + GE SP E + ++ + V+++
Sbjct: 475 EKEAKEEEGKEEEGGEE----------EEAEGGEEETKSPPAEEAASPEKEAKSPVKEEA 524
Query: 493 EAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKS-ATLSSTEST 551
++ A S +++ + S +K +P K + K E ++ KS A + S E
Sbjct: 525 KSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKA 584
Query: 552 ASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGG 611
S +EE K E PE+ K V +K A S EE A
Sbjct: 585 KSPAKEEAKSPAEAKSPEKAKSPVKE-----------EAKSPAEAKSPVKEEAKSPAEVK 633
Query: 612 DHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPR 671
+KA K++ + + +E + SPE+A SP + E S E K V
Sbjct: 634 SPEKAKSPTKEEAKSPEKAKSPEKEE-----AKSPEKAKSPVKAEAKSP-EKAKSPVKAE 687
Query: 672 KKSKSKL-----EEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQE 726
KS K EE A S V+ P K +S V + P + K P ++
Sbjct: 688 AKSPEKAKSPVKEEAKSPEKAKSPVKEEA--KSPEKAKSPVKEEAKTP-EKAKSPVKEEA 744
Query: 727 QAPVEDAGPTGANEDDSDVP-AVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKE 785
++P + P A D P A P E +K + KS + E K+ +
Sbjct: 745 KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKF--PEKAKSPVKEEVKSPEKAKSP 802
Query: 786 LSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIA 845
L E + + EE P V EP ++ E E A T + E++
Sbjct: 803 LKEDAKAPEKEIPKKEEVKSPVKEEEKPQ--EVKVKEPPKKAEEEKAPATPKTEEKKDSK 860
Query: 846 EEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMV 905
+EE P P P+ E + V E EA + AE+ ++
Sbjct: 861 KEEAPKKEAPKPKVEEKKEPAVEKPKESKVEA----------------KKEEAEDKKKVP 904
Query: 906 SAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPE 965
+ + + E+A P ++ E V E + + +E + +K PE
Sbjct: 905 TPEKEAPAKVEVKEDAKPKEKTE--VAKKEPDDAKAKEPSKPAEKK---------EAAPE 953
Query: 966 DVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKA 1025
+ + +A++PEE+ + KE D L + + K E + Q + EKA
Sbjct: 954 K--KDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKA 1011
Query: 1026 PQ 1027
+
Sbjct: 1012 TE 1013
Score = 86.7 bits (213), Expect = 2e-16
Identities = 122/557 (21%), Positives = 216/557 (38%), Gaps = 61/557 (10%)
Query: 25 EMATKSAVVHDITDDGQEETPEIIE-QIPSSESNLEELTQPTESQANDIGFKKVFKFVGF 83
E KS V + + ++PE E + P+ + E+ P + +A K
Sbjct: 513 EKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAK------- 565
Query: 84 KFTVKKDKTEKPDTVQLLTVKKDEG-EGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPE 142
+ +K++ + P V+ K E A + K P +A S E +S + +
Sbjct: 566 --SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPE----KAKSPVKEEAKSPAEAK 619
Query: 143 ETLKRE-QSHAEISPP--AESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFK 199
+K E +S AE+ P A+S E E + EKE +KS E SPV +E S +
Sbjct: 620 SPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSP-E 678
Query: 200 KFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAH 259
K + A + + P ++E ++ EK K E+ + E K+ V E T +
Sbjct: 679 KAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKS 738
Query: 260 PQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVA 319
P + E A P EK + P + + + P + PA +K + V
Sbjct: 739 PVK--EEAKSP------EKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVK 790
Query: 320 EVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPT 379
E V + E+ K + + +P +E V+ P + E + VK+KE E+
Sbjct: 791 E-EVKSPEKAKSPLKEDAKAPEKEIPKKEEVK---SPVKEEEKPQEVKVKEPPKKAEEEK 846
Query: 380 QGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKR 439
A +EK SK E E +E+ + K+ K+ KK
Sbjct: 847 APATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKE-------SKVEAKK----- 894
Query: 440 GGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGAT 499
EE+ + +VP ++ + + + A E+ E +A+ + D + +
Sbjct: 895 ----EEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTE--------VAKKEPDDAKAKEPS 942
Query: 500 SDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEM 559
EKK A+ +K T +++ ++P E K + K TLS S + E
Sbjct: 943 KPAEKKE------AAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEK 996
Query: 560 KGSVEEPKPEEPKRKVD 576
S ++ + P++ +
Sbjct: 997 SSSTDQKDSKPPEKATE 1013
Score = 82.8 bits (203), Expect = 3e-15
Identities = 160/676 (23%), Positives = 257/676 (38%), Gaps = 94/676 (13%)
Query: 218 PKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYE 277
PK V K K +E KV E+ K V E+ T Q +E E + E +
Sbjct: 427 PKIPSVSTHIKVKSEEKIKV-VEKSEKETVIVEEQTEETQV-TEEVTEEEEKEAKEEEGK 484
Query: 278 KVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEV 337
+ E EE+ G + ++ PA A E +EE + + E+ + EV
Sbjct: 485 EEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV 544
Query: 338 E--ETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPP 395
+ E A S PA+E E + P+ P KE K A++ EK S
Sbjct: 545 KSPEKAKS-PAKE--EAKSPPEAKSPEKEEAK------------SPAEVKSPEKAKSPAK 589
Query: 396 EGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPAD 455
E S E S E+ K SP+K+ S K K++ + + +S E + P
Sbjct: 590 EEAKSPAE-AKSPEKAK---SPVKEEAKSPAEAKSPVKEE--AKSPAEVKSPEKAKSP-- 641
Query: 456 SPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASF 515
++EE K A SPE+ EE EK + V+ + ++ E A S K E +P
Sbjct: 642 ---TKEEAKSPEKAKSPEK-EEAKSPEKAKSPVKAEAKSPEKAKS--PVKAEAKSP---- 691
Query: 516 KKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKV 575
+K +P K + E K ++ K S E S ++EE K PE+ K V
Sbjct: 692 EKAKSPVKEEAKSPEKAKSPVKEEAK-----SPEKAKSPVKEEAK------TPEKAKSPV 740
Query: 576 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 635
+A + K+ E K + + ++
Sbjct: 741 K-----------------------------EEAKSPEKAKSPEKAKTLDVKSPEAKTPAK 771
Query: 636 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 695
E PE+A SP + E S ++ L K + ++ +K E + E
Sbjct: 772 EEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEE--VKSPVKEEEK 829
Query: 696 PDTEPGKEESWVSIKKFIPG--RRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSE 753
P KE + ++ P + +++ D K+E+AP ++A E PAV E
Sbjct: 830 PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKE--PAVEKPKE 887
Query: 754 YDAVEREKMEAQQAQK-SAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERS 812
VE +K EA+ +K + E A EV ++ + +A D +A E
Sbjct: 888 -SKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAK---EPSK 943
Query: 813 PSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTV----TEPLPENREARGDTVV 868
P+ + E + E E A EE + E A+E+ T+ ++P E E T
Sbjct: 944 PAEKKEAAPEKKDTKE-EKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQ 1002
Query: 869 SEAELTPEAVTAAETA 884
+++ PE T + A
Sbjct: 1003 KDSK-PPEKATEDKAA 1017
Score = 72.8 bits (177), Expect = 3e-12
Identities = 96/393 (24%), Positives = 165/393 (41%), Gaps = 22/393 (5%)
Query: 118 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEK 177
K+ + +A S E E +S EK + +K E E A+S E E + K
Sbjct: 643 KEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPE---KAKSPVKAEAKSPEKAKSPVK 699
Query: 178 EPSKSAESPTSPVTSETGSTFK-KFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEK 236
E +KS E SPV E S K K + A +K + P ++E ++ EK K E K
Sbjct: 700 EEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKA--KSPVKEEAKSPEKAKSPEKAK 757
Query: 237 -VDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGP-S 294
+D + A E+ + P++ E S E K L + + + P
Sbjct: 758 TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKK 817
Query: 295 EEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDA 354
EE +P+ E ++++V + AE + +TEE+K +E A P +E +
Sbjct: 818 EEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEA---PKKEAPKPKV 874
Query: 355 EPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQ 414
E ++ EPA E K KE+ V + + + D+K + P + ++VE + + K +
Sbjct: 875 E-EKKEPAVE--KPKESKVEAK-----KEEAEDKKKVPTPEKEAPAKVE-VKEDAKPKEK 925
Query: 415 GSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEH-TQVPADSPDSQEEQKGESSASSPE 473
KK K+ S +K + +++ E + P + P ++ + K + S E
Sbjct: 926 TEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKE 985
Query: 474 EPE-EITCLEKGLAEVQQDGEAEEGATSDGEKK 505
+ + EK + Q+D + E AT D K
Sbjct: 986 PSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAK 1018
Score = 72.0 bits (175), Expect = 5e-12
Identities = 140/595 (23%), Positives = 233/595 (39%), Gaps = 85/595 (14%)
Query: 1130 VFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGS 1189
+ +E+T+E E+ E +KE E + G +E + +E+TK P E
Sbjct: 456 IVEEQTEETQVTEEVTEEEEKEAKEEEGK--EEEGGEEEEAEGGEEETKSPPAEEA---- 509
Query: 1190 IDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHA--KSPP---SPVEREMVVQVE 1244
S EK + +K E AE K + E +S A KSP SP + E E
Sbjct: 510 ------ASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPE 563
Query: 1245 REKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQT-----VNVPIIDGAKEVSSLEGSPP 1299
+ E E E E A + ++E +K + P+ + AK S E P
Sbjct: 564 AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK--SPAEAKSP 621
Query: 1300 PCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEP--AGAHLVLEE 1357
+E + +V+S E + + T +EE E A E E P A + + E
Sbjct: 622 V----KEEAKSPAEVKSPEKAKSPT---KEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674
Query: 1358 KSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEV 1417
KS EK A A P+ +AKS PV A + + S ++ E + K KS
Sbjct: 675 KSPEK-----AKSPVKAEAKSPE-KAKS-PVKEEAKSPEKAKSPVKEEAKSPEKAKSPVK 727
Query: 1418 DEQVACQEVKVSVAIEDLEPENG-------ILELETKSSKL-VQNIIQTAVDQF------ 1463
+E ++ K V E PE L++++ +K + ++ D+F
Sbjct: 728 EEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKS 787
Query: 1464 -VRTEETATEMLTSELQTQAHVIKADSQDAGQETE-----KEGEEPQASAQDETPITSAK 1517
V+ E + E S L+ A KA ++ ++ E KE E+PQ E P + +
Sbjct: 788 PVKEEVKSPEKAKSPLKEDA---KAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEE 844
Query: 1518 EESESTAVGQAHSDISKDMSEASEKTMT-VEVEGSTVNDQQLEEVVLPSEEEGGGAGTKS 1576
E++ +T + D K+ + E VE + ++ E V +EE
Sbjct: 845 EKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVP 904
Query: 1577 VPEDDGHALL-----AERIEKSLVEPKE--DEKGDDVDDPENQNSALADTDASGGLTKES 1629
PE + A + A+ EK+ V KE D K + P + A E
Sbjct: 905 TPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEA----------APEK 954
Query: 1630 PDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES 1684
DT K K+ E+ + E + E DK ++ + + ++ +S+ ++ +S
Sbjct: 955 KDTKEEKAKKPEEKPKTEAKA----KEDDKTLSKEPSKPKAEKAEKSSSTDQKDS 1005
Score = 71.2 bits (173), Expect = 8e-12
Identities = 149/722 (20%), Positives = 275/722 (38%), Gaps = 75/722 (10%)
Query: 745 VPAVVPLSEYDAVEREKM-EAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGT- 802
V + + E+ V +++ EA + A + Q+ TE ++L + A +
Sbjct: 283 VQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSL 342
Query: 803 -RAATIIEERSPSWISASVTEPLEQVEAE--------AALLTE--EVLEREVIAEEEPPT 851
R + +E+R + I AS E ++Q++AE AA L E ++L ++ + E
Sbjct: 343 ERQRSELEDRHQADI-ASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAA 401
Query: 852 VTEPLPENREAR---GDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAV 908
+ L E E R G S E P+ + + T + +EE + E++ + V
Sbjct: 402 YRKLL-EGEECRIGFGPIPFSLPEGLPK-IPSVSTHIKVKSEE--KIKVVEKSEKETVIV 457
Query: 909 SQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVL 968
+ T+ TEE T +E E + +E+E +E + E+ K ++
Sbjct: 458 EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAK 517
Query: 969 QPVQR-----AEAERPE-EQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESF 1022
PV+ AEA+ PE E+A++ K + +EAK+ P + + +
Sbjct: 518 SPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAE 577
Query: 1023 EKAPQVTESIESSELVTTCQAETLAGVKS------------QEMVMEQAIPPDSVETPTD 1070
K+P+ +S E + +A++ KS + V E+A P V++P
Sbjct: 578 VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEK 637
Query: 1071 SETDGSTPVADFDAPGTTQKDEIVEIHE-ENEVASGTQS-----GGTEAEAVPAQKERPP 1124
+++ + + +K+E + ++ V + +S +AEA +K + P
Sbjct: 638 AKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSP 697
Query: 1125 APSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFE 1184
E+ K K E K E K + + + + EK K +
Sbjct: 698 VKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAK 757
Query: 1185 GLEGSIDTGITVSREKVTEVA------LKGEGTEEAECKKDDALELQSHAKSPPSPV-ER 1237
L+ T ++E+ A K EE + + L+ AK+P + ++
Sbjct: 758 TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKK 817
Query: 1238 EMVVQVEREKTEAEPTHVNE--EKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLE 1295
E V +E+ + + V E +K E E A + K+ D KE + +
Sbjct: 818 EEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK----------DSKKEEAPKK 867
Query: 1296 GSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVL 1355
+P P + +++ + +S E +K E + T E PA +
Sbjct: 868 EAPKPKVEEKKEPAVEKPKESK---------VEAKKEEAEDKKKVPTPEKEAPAKVEVKE 918
Query: 1356 EEKSSEKNEDFAAHPGEDAVPTGPDCQA-KSTPVIVSATTKKGLSSDLEGEKTTSLKWKS 1414
+ K EK E P +DA P A K TK+ + E + T K K
Sbjct: 919 DAKPKEKTEVAKKEP-DDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKE 977
Query: 1415 DE 1416
D+
Sbjct: 978 DD 979
Score = 64.3 bits (155), Expect = 9e-10
Identities = 129/556 (23%), Positives = 208/556 (37%), Gaps = 110/556 (19%)
Query: 1140 KMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSRE 1199
K E+ ++ +K ETV + +TE TQ ++ +E+ K+ EG +E
Sbjct: 439 KSEEKIKVVEKSEK-ETVIVEEQTEETQVTEEVTEEEEKEAKEEEG------------KE 485
Query: 1200 KVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEK 1259
+ + EG EE E K A E S K SPV+ E E + E E E
Sbjct: 486 EEGGEEEEAEGGEE-ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV 544
Query: 1260 LEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQE-EAVCTKIQVQSSE 1318
E A + ++E +K SPP E E + +V+S E
Sbjct: 545 KSPEKAKSPAKEEAK----------------------SPPEAKSPEKEEAKSPAEVKSPE 582
Query: 1319 ASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTG 1378
+ + A EE K PA A + KS K E A P E P
Sbjct: 583 KA--KSPAKEEAK---------------SPAEAKSPEKAKSPVKEE--AKSPAEAKSPVK 623
Query: 1379 PDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPE 1438
+ AKS + S K S + E + K KS E +E + ++ K V E PE
Sbjct: 624 EE--AKSPAEVKSPEKAK---SPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPE 678
Query: 1439 NGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEK 1498
+ KS V+ E + E S ++ +A + A ++
Sbjct: 679 ------KAKSP--------------VKAEAKSPEKAKSPVKEEAK----SPEKAKSPVKE 714
Query: 1499 EGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQL 1558
E + P+ + E+++S +A S + +++ EK T++V+
Sbjct: 715 EAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP---EKAKSPEKAKTLDVKSPEAKTPAK 771
Query: 1559 EEVVLPS------------EEEGGGAGTKSVPEDDGHALLAERIEKSLVEP--KEDEKGD 1604
EE P+ EE KS ++D A E +K V+ KE+EK
Sbjct: 772 EEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQ 831
Query: 1605 DVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAI--T 1662
+V E A + + +P T K +KE+A + E + KV + + A+
Sbjct: 832 EVKVKEPPKKAEEEKAPA------TPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP 885
Query: 1663 PQAQEELQKQERESAK 1678
+++ E +K+E E K
Sbjct: 886 KESKVEAKKEEAEDKK 901
Score = 55.1 bits (131), Expect = 6e-07
Identities = 115/510 (22%), Positives = 198/510 (38%), Gaps = 55/510 (10%)
Query: 1197 SREKVTEVA--LKGEGTE-EAECKKDDALELQS------HAKSPPSPVEREMVVQVEREK 1247
++E++TE L+ TE EA D+LE Q H S E + E
Sbjct: 314 AQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRN 373
Query: 1248 TE---AEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQ 1304
T+ A ++ L + A+ + ++LL+ I G S EG P +
Sbjct: 374 TKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLP-----K 428
Query: 1305 EEAVCTKIQVQSSEASFTLTAAAEEEKVLGE--TANILETGETLEPAGAHLVLEEKSSEK 1362
+V T I+V+S E + +E+E V+ E T T E E EEK +++
Sbjct: 429 IPSVSTHIKVKSEE-KIKVVEKSEKETVIVEEQTEETQVTEEVTEE-------EEKEAKE 480
Query: 1363 NEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVA 1422
E GE+ G + + KS P +A+ +K S ++ E + + KS E +E +
Sbjct: 481 EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS 540
Query: 1423 CQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQA 1482
EVK + E E KS + + V++ E A E ++ A
Sbjct: 541 PAEVKSPEKAKSPAKEEAKSPPEAKSPEKE----EAKSPAEVKSPEKAKSPAKEEAKSPA 596
Query: 1483 HVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEK 1542
+A S + + K EE ++ A+ ++P+ KEE++S A K +A
Sbjct: 597 ---EAKSPEKAKSPVK--EEAKSPAEAKSPV---KEEAKSPAE-------VKSPEKAKSP 641
Query: 1543 TMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAE--RIEKSLVEPKED 1600
T + EE P + + PE + AE EK+ KE+
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEE 701
Query: 1601 EKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKA 1660
K + + A + A + +E+ K KE+A+ E + +++
Sbjct: 702 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDV 761
Query: 1661 ITPQAQEELQKQER-------ESAKSELTE 1683
+P+A+ +++ R E AKS + E
Sbjct: 762 KSPEAKTPAKEEARSPADKFPEKAKSPVKE 791
Score = 41.6 bits (96), Expect = 0.007
Identities = 53/235 (22%), Positives = 93/235 (39%), Gaps = 36/235 (15%)
Query: 23 DKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVG 82
+KE+ K V + ++ + + ++ E +E T TE + D ++ K
Sbjct: 811 EKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEK-KDSKKEEAPKKEA 869
Query: 83 FKFTVKKDK---TEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASK-----ESEP 134
K V++ K EKP ++ KK+E E D K EA +K +++P
Sbjct: 870 PKPKVEEKKEPAVEKPKESKV-EAKKEEAE------DKKKVPTPEKEAPAKVEVKEDAKP 922
Query: 135 KQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSET 194
K+ TE K+E A+ P++ + E E+ + K+EK + T E
Sbjct: 923 KEKTE----VAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKED 978
Query: 195 GSTFKKFFTQGWAGWRKKTSFRKPKEDEVEAS---EKKKEQEPEKVDTEEDGKAE 246
T K KPK ++ E S ++K + PEK ++ K +
Sbjct: 979 DKTLSK-------------EPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 87.0 bits (214), Expect = 1e-16
Identities = 129/615 (20%), Positives = 231/615 (37%), Gaps = 66/615 (10%)
Query: 212 KTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPR 271
+ S R +E + + + +EP+ + E +AE+ + T + H
Sbjct: 449 RCSERNLQESVLSEQDLMQPEEPDYLLDEMTKEAEIDNSS-TVESLGETTDILNMTHIMS 507
Query: 272 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFD----EKIEVHQEEVVAEVHVS--- 324
L++ + ++L ++ Q E TE D E++ +E + HVS
Sbjct: 508 LNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGI 567
Query: 325 -------TVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKL-----KETC 372
T+E ++E+ EE G AE+ E QE E +E VK+ ++T
Sbjct: 568 FMTQPATTIEAFSDEEVEIPEEKEG---AEDSKGNGIEEQEVEANEENVKVHGGRKEKTE 624
Query: 373 VSGEDPTQGADLSPDE-KVLSKPPEGVV-----------SEVEMLSSQERMKVQGSPLKK 420
+ +D T A++S + K + + +G S E +ER K + +
Sbjct: 625 ILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRG 684
Query: 421 LFT--STGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEI 478
G K+L+ K++ KR G ++E E Q + + E+ GE EE E
Sbjct: 685 EMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEG- 743
Query: 479 TCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELD 538
D E EE +G+++ EG +K +K+ R + +K +E
Sbjct: 744 ------------DREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEG 791
Query: 539 KVKSATLSSTESTASEMQEEMK---GSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRAR 595
TE E +E + G VEE K E + + + G ++
Sbjct: 792 DQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEE-----------GEGEEEEG 840
Query: 596 RGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEG 655
G + EG + G ++ E G+ +E G +G G +E G+G E G EG
Sbjct: 841 EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 900
Query: 656 EGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPG 715
EG E ++ + K EE+ E+ E + E G+ E ++
Sbjct: 901 EGEGEEEGEGE--GEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGE 958
Query: 716 RRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPE 775
+ +G++E + G E++ + E + E + E + + E+ E
Sbjct: 959 EEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEE 1018
Query: 776 QKAATEVSKELSESQ 790
+ EV E E +
Sbjct: 1019 GEVEGEVEGEEGEGE 1033
Score = 84.3 bits (207), Expect = 9e-16
Identities = 120/492 (24%), Positives = 198/492 (40%), Gaps = 71/492 (14%)
Query: 104 KKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQA 163
++++GE G G+ + P G E A KE K+ E+ E+ +REQ H + E Q
Sbjct: 673 EREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQK-EREQGHQK-----ERNQE 726
Query: 164 VEE-CKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDE 222
+EE +EE E +E+E + E E G + G R+K + KE+
Sbjct: 727 MEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGE------GEEVEGEREKEEGERKKEER 780
Query: 223 VEASEKKKEQ----EPEKVDT-------EEDGKAEVASEKLTASEQAHPQEPAESAHEPR 271
EK +E+ E E+ +T EE G+ E + E+ +E E E
Sbjct: 781 AGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEE-- 838
Query: 272 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 331
E E E E + +G EE+ E E+ E EE E E E
Sbjct: 839 ---EGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGE------GEGEE 889
Query: 332 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 391
E + E EE G EE E + E +E E E E+ +G +E+
Sbjct: 890 EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGE-----------EEGEEGEGEGEEEEGE 938
Query: 392 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 451
+ +G E E + +G G ++ G+ ++G+ G G+EE GE
Sbjct: 939 GEGEDGEGEGEEEEGEWEGEEEEGE-------GEGEEEGEGEGEEGE-GEGEEEEGE--- 987
Query: 452 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAE---EGATSDGEKKREG 508
+ + + E++GE EE E G E +++GE E EG +GE + E
Sbjct: 988 --GEGEEEEGEEEGEEEGEGEEEGE-------GEGEEEEEGEVEGEVEGEEGEGEGEEEE 1038
Query: 509 VTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQE--EMKGSVEEP 566
++ + RR E ++E+E ++ + E ++ ++KGSV+
Sbjct: 1039 GEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYG 1098
Query: 567 KPEEPKRKVDTS 578
K + ++K T+
Sbjct: 1099 KHKTYQKKSVTN 1110
Score = 70.5 bits (171), Expect = 1e-11
Identities = 139/690 (20%), Positives = 249/690 (36%), Gaps = 121/690 (17%)
Query: 129 SKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTS 188
S S K P + K++Q+ E++ ++ + +E EE E + K+
Sbjct: 507 SLNSNEKSLKLSPVQKQKKQQTIGELTQ--DTALTENDDSDEYEEMSEMKEGKAC----- 559
Query: 189 PVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKK-----------KEQEPE-- 235
K+ +QG + T+ ++EVE E+K +EQE E
Sbjct: 560 ----------KQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEAN 609
Query: 236 ----KVDTEEDGKAEVASEKLT-----ASEQAHPQEPAESAHEPRLSAEYEKVELPSE-- 284
KV K E+ S+ LT + +A AE E R E+ +E
Sbjct: 610 EENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHW 669
Query: 285 -----EQVSGSQGPSE-EKPAPLATEVFDE---KIEVHQEEVVAEVHVSTVEERTEEQKT 335
E+ +G E E+P E+ ++ K +E+ E +ER +E +
Sbjct: 670 QDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEE 729
Query: 336 EVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPP 395
EE G EE + E +E E G++ +G ++ + +
Sbjct: 730 GGEEEHGEGEEEEGDREEEEEKEGE--------------GKEEGEGEEVEGER----EKE 771
Query: 396 EGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPAD 455
EG + E +E+ + +G G ++ + + + K GG+ E GE + +
Sbjct: 772 EGERKKEERAGKEEKGEEEGD------QGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGE 825
Query: 456 SPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASF 515
+ +EE +GE EE E E+G + +++GE EG E + EG
Sbjct: 826 REEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEG------- 878
Query: 516 KKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKV 575
++ E + E E ++ + E +EE +G EE E
Sbjct: 879 -----EEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGE---- 929
Query: 576 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 635
G ++ G D EG G+ ++ + G+++E +G G
Sbjct: 930 ------------GEGEEEEGEGEGEDGEG-----EGEEEEGEWEGEEEEGEGEGEEEGEG 972
Query: 636 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAG--SGVEH 693
E + G+G E+ EGE E + ++ + + EE+ E + G G E
Sbjct: 973 EGEEGEGEGEEEEGEG--EGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEG 1030
Query: 694 STPDTEPGKEESWVSIKKFIPG--RRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 751
E EE +K G R+ R + ++E+ ++ G D +
Sbjct: 1031 EGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGE------- 1083
Query: 752 SEYDAVEREKMEAQQAQKSAEQPEQKAATE 781
EY V + K + + Q + T+
Sbjct: 1084 -EYKKVSKIKGSVKYGKHKTYQKKSVTNTQ 1112
Score = 56.6 bits (135), Expect = 2e-07
Identities = 149/749 (19%), Positives = 255/749 (34%), Gaps = 114/749 (15%)
Query: 460 QEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMV 519
QE E PEEP+ + L E+ ++ E + +T + + + +
Sbjct: 456 QESVLSEQDLMQPEEPDYL------LDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLN 509
Query: 520 TPKKRVR-RPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKP---------- 568
+ +K ++ P + K+ + + + TE+ S+ EEM ++E K
Sbjct: 510 SNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMS-EMKEGKACKQHVSQGIF 568
Query: 569 -EEPKRKVDTSVSWEALICVGSSKKRARRGSSSDE------EGGPKAMGGDHQKADEAGK 621
+P ++ E I +G+ +E E K GG +K +
Sbjct: 569 MTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSD 628
Query: 622 DKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVST---WESFKRLVTPRKKSKSKL 678
D + ++ + G+ PE G T EG S W+ +R + K + ++
Sbjct: 629 DLTDKAE--VSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEM 686
Query: 679 EEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGA 738
E E + E ++E W KKR +QEQ E
Sbjct: 687 ERPGEG------------EKELAEKEEW-----------KKRDGEEQEQKEREQGHQKER 723
Query: 739 NED-DSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAA 797
N++ + E + +RE+ E ++ + E ++ E KE E + A
Sbjct: 724 NQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGK 783
Query: 798 VADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLP 857
G E E E E E + E ERE EE E
Sbjct: 784 EEKGEEEGDQGEGEEEE-TEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEG 842
Query: 858 ENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDT 917
E E G+ E + G EEG E EE E + +
Sbjct: 843 EEEEGEGEEEEGEGK---------------GEEEGEEGEGEEEGEEGEGEGEEEEGEGEG 887
Query: 918 TEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE 977
EE E E G + EE+ E + + +E + G G E+ + E E
Sbjct: 888 EEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGE 947
Query: 978 RPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKV-VGQTTPESFEKAPQVTESIESSE 1036
EE+ E G ++E + E + E +G+ G+ E E + E E E
Sbjct: 948 GEEEEGEWEGEEEEGE-------GEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGE 1000
Query: 1037 LVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEI 1096
E G + E E + E + E +G + G +++E E
Sbjct: 1001 -------EEGEGEEEGEGEGE-----EEEEGEVEGEVEGE------EGEGEGEEEEGEEE 1042
Query: 1097 HEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVET 1156
EE E E E ++ R +EE +E+ K ++T E ++ E
Sbjct: 1043 GEERE---------KEGEGEENRRNR---------EEEEEEEGKYQETGEEENERQDGEE 1084
Query: 1157 VSILSKTEGTQEADQYADEKTKDVPFFEG 1185
+SK +G+ + ++ + K V +G
Sbjct: 1085 YKKVSKIKGSVKYGKHKTYQKKSVTNTQG 1113
Score = 52.4 bits (124), Expect = 4e-06
Identities = 129/647 (19%), Positives = 229/647 (35%), Gaps = 60/647 (9%)
Query: 1051 SQEMVMEQAIPPDSVETPTDSE--TDGSTPVADFDAPGTTQK-DEIVEIHEENEVASGTQ 1107
S+ + E + + P + + D T A+ D T + E +I + S
Sbjct: 451 SERNLQESVLSEQDLMQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMS-LN 509
Query: 1108 SGGTEAEAVPAQKERPPAPSSFVFQE----ETKEQSKMEDTLEHTDKEVSVETVSI-LSK 1162
S + P QK++ + Q+ E + + E+ E + + + VS +
Sbjct: 510 SNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFM 569
Query: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEG--TEEAECKKDD 1220
T+ + ++DE+ + EG E S GI + E +K G E+ E DD
Sbjct: 570 TQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDD 629
Query: 1221 ALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTV 1280
+ ++ V R E E + E ++ + ++
Sbjct: 630 LTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERP 689
Query: 1281 NVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANIL 1340
+G KE++ E G+E+ + Q E + + EEE GE
Sbjct: 690 G----EGEKELAEKEEWKKRD-GEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEE---- 740
Query: 1341 ETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSS 1400
E G+ E EEK E E+ GE+ + + + +KG
Sbjct: 741 EEGDREEE-------EEKEGEGKEE---GEGEEVEGEREKEEGERKKEERAGKEEKGEEE 790
Query: 1401 DLEGE---KTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQ 1457
+GE + T + + E +V EV+ + E E G E E +
Sbjct: 791 GDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE------- 843
Query: 1458 TAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAK 1517
EE E E + + + + ++ G+E E EGEE + + E
Sbjct: 844 --------EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEG 895
Query: 1518 EESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSV 1577
EE E G+ + + E K E EG + EE E+G G G +
Sbjct: 896 EEEEGEGEGEEEGEGEGEEEEGEGKG---EEEGEEGEGEGEEEEGEGEGEDGEGEGEEEE 952
Query: 1578 PEDDGHALLAERIEKSLVEPK----EDEKGDDVDDPENQNSALADTDASGGLTKESPDTN 1633
E +G E + E + E E ++ + E + + G +E +
Sbjct: 953 GEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGE 1012
Query: 1634 GPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1680
G +++E E EVE +EG+ E + + +EE +++E+E E
Sbjct: 1013 GEEEEEGEVEGEVEGEEGEGEGEEE-----EGEEEGEEREKEGEGEE 1054
Score = 50.1 bits (118), Expect = 2e-05
Identities = 127/605 (20%), Positives = 211/605 (34%), Gaps = 101/605 (16%)
Query: 1085 PGTTQK---DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEE--TKEQS 1139
P TT + DE VEI EE E A ++ G E + V A +E + E + + +
Sbjct: 572 PATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLT 631
Query: 1140 KMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSRE 1199
+ E K V + +GT E E +D E +G D G
Sbjct: 632 DKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDE---EREKGEKDKGRG---- 684
Query: 1200 KVTEVALKGEG----TEEAECKKDDALELQSHAKSPPSPVER--EMVVQVEREKTEAEPT 1253
E+ GEG E+ E KK D E + + ER EM E E E E
Sbjct: 685 ---EMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEE 741
Query: 1254 HVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQ 1313
+ E+ E + E ++ ++G +E E G+EE + +
Sbjct: 742 EGDREEEEEKEGEGKEEGEGEE---------VEGEREKEEGERKKEERAGKEEK--GEEE 790
Query: 1314 VQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGED 1373
E T EEK E +E GE +EE E+ E+ GE+
Sbjct: 791 GDQGEGEEEETEGRGEEK---EEGGEVEGGE----------VEEGKGEREEEEEEGEGEE 837
Query: 1374 AVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIE 1433
G + ++G + EGE + + E +E+ E
Sbjct: 838 EEGEGEE--------------EEGEGEEEEGEGKGEEEGEEGEGEEEG-----------E 872
Query: 1434 DLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAG 1493
+ E E E E + + + + + EE E + + + ++ G
Sbjct: 873 EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEE-------GEGEGEEEEGEGKGEEEG 925
Query: 1494 QETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTV 1553
+E E EGEE + + E +EE G+ + + E E+ E EG
Sbjct: 926 EEGEGEGEEEEGEGEGEDGEGEGEEEE-----GEWEGEEEEGEGEGEEEG---EGEG--- 974
Query: 1554 NDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQN 1613
EEG G G + E +G E + E +E+ +G+ ++ E +
Sbjct: 975 -------------EEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEV 1021
Query: 1614 SALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQE 1673
+ + G +E +++EKE E + + E + +EE ++Q+
Sbjct: 1022 EGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQD 1081
Query: 1674 RESAK 1678
E K
Sbjct: 1082 GEEYK 1086
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 87.0 bits (214), Expect = 1e-16
Identities = 302/1563 (19%), Positives = 543/1563 (34%), Gaps = 262/1563 (16%)
Query: 209 WRKKTSF-RKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESA 267
W++ + RK K +E A + KK + + + T E + E +E TA +A P+ S
Sbjct: 53 WQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETA--KATPR--LAST 108
Query: 268 HEPRLSAEYE---KVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVS 324
+ L A+ K + +E + +G G S PA T + ++ + +
Sbjct: 109 NSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
Query: 325 TVEERTEE------------------QKTEVEETAGSVPAEELVEMDAEPQEAEPAKELV 366
V E EE Q E S E VE + A+ V
Sbjct: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV 228
Query: 367 KLKETCVSGEDPTQG--ADLSPDEKVLSKPP---------------EGVVSEVEM-LSSQ 408
KE+ P G D++P K + PP EG SE E ++
Sbjct: 229 STKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTR 288
Query: 409 ERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESS 468
++K L+ S K GK G G+ V + + + E+ ESS
Sbjct: 289 SQVKASEKILQVRAASAPAKGTPGK------GATPAPPGKAGAVASQTKAGKPEEDSESS 342
Query: 469 ASSPEEPEEITCLEKGLAEVQQDGEAEE-GATSDGEKK--REGVTPWASFKKMVTPKKRV 525
+ + EE T K L + + G+ + GA S K+ R+G P K K
Sbjct: 343 SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQ 402
Query: 526 RRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWE--- 582
E D + ++ S + ++ S +++ + P E P++ + +
Sbjct: 403 AGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA-SAPAKESPRKGAAPAPPRKTGP 461
Query: 583 --ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPG 640
A + VG ++ +R S + + + GK + + G G
Sbjct: 462 AAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM-GMGPLGKG 520
Query: 641 QGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDT-E 699
G P + G T V WE + S+S EE S+ S + P
Sbjct: 521 AGPVPPGKVGPATPSAQVGKWE---------EDSESSSEESSDSS------DGEVPTAVA 565
Query: 700 PGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVER 759
P +E+S +I + +P + P + AGP V A P+ ++ E
Sbjct: 566 PAQEKSLGNILQ-------AKPTSSPAKGPPQKAGPVAVQ-----VKAEKPMDNSESSEE 613
Query: 760 EK-----------MEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATII 808
M A QA+ + + P+ KA + + + ++V + +A T
Sbjct: 614 SSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT 673
Query: 809 EERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVV 868
SP+ S +V ++ +++ E +EEE + + + + V
Sbjct: 674 ---SPAGSSPAVAGGTQRPAEDSSS------SEESDSEEEKTGLAVTVGQAKSVGKGLQV 724
Query: 869 SEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVE 928
A + + TA L + G T V A Q + +++EE + +E
Sbjct: 725 KAASVPVKGSLGQGTAPVLPGKTGP-------TVTQVKAEKQ--EDSESSEEESDSEEAA 775
Query: 929 GGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT-GGPEDVLQPVQRAEAERPEEQAEASG 987
++ ++TQ A + GT P V+ +A+ P +
Sbjct: 776 ASPAQVKTSVKKTQAKANPAAARAPSAK---GTISAPGKVVTAAAQAKQRSPSKVKPPVR 832
Query: 988 LKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLA 1047
+ + V+ + A QT PE E + E +S E +AETLA
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPE--EDSGSSEEESDSEE-----EAETLA 885
Query: 1048 GVKSQEMV--MEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASG 1105
VK + A+ P +S G+ P PG T +++ +S
Sbjct: 886 QVKPSGKTHQIRAALAPAK-----ESPRKGAAPTP----PGKTGPSAAQAGKQDDSGSSS 936
Query: 1106 TQS---GGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK 1162
+S G A AQ +PP +F + + + T + T
Sbjct: 937 EESDSDGEAPAAVTSAQVIKPP----LIFVDPNRSPAGPAATPAQAQ---AASTPRKARA 989
Query: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1222
+E T + E +P + L I T + +A K + K+ +
Sbjct: 990 SESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRI 1049
Query: 1223 ELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNV 1282
+ +K E T V ++AV S Q
Sbjct: 1050 S--------------------DGKKQEGPATQV-------DSAVGTLPATSPQSTSVQ-- 1080
Query: 1283 PIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILET 1342
AK + L P + ++A SE S ++ +EE+ GE ++
Sbjct: 1081 -----AKGTNKLRKPKLPEV--QQATKAPESSDDSEDSSDSSSGSEED---GEGPQGAKS 1130
Query: 1343 GETL--EPAGAHLVLEEKSSEKNEDFAAHPGEDAVP-------TGPDCQA-KSTPVIVSA 1392
TL P+ ++EE ++E +ED P + + T + QA K+TP + S+
Sbjct: 1131 AHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSS 1190
Query: 1393 ---TTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIE-DLEPENGILELETKS 1448
++ D +G++ + + + + +E + +P+ G + +
Sbjct: 1191 PSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQAST 1250
Query: 1449 SKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQ 1508
L NI Q + Q +E Q QA V+K ++ QE +K + + S++
Sbjct: 1251 LALQSNITQCLLGQ---------PWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSR 1301
Query: 1509 DETPITSAKEESESTAVGQAHSDISKDMS-----EAS---EKTMTVEVEGSTVNDQQLEE 1560
K + A S K + EAS EKT T +G D+ +
Sbjct: 1302 KGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTS-KGKAKRDKASGD 1360
Query: 1561 VVLPSEEEGGGA----GTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSAL 1616
V E++G G+ G K PE E ++K + +G D +P+++
Sbjct: 1361 V---KEKKGKGSLGSQGAKDEPE--------EELQKGM----GTVEGGDQSNPKSK---- 1401
Query: 1617 ADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERES 1676
K+K+K D ++ + ++ + ++ KA T ++ QK++++
Sbjct: 1402 -------------------KEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKK 1442
Query: 1677 AKS 1679
K+
Sbjct: 1443 KKT 1445
Score = 80.9 bits (198), Expect = 1e-14
Identities = 242/1223 (19%), Positives = 414/1223 (33%), Gaps = 210/1223 (17%)
Query: 88 KKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPS-----LGAGEAASKESEPKQSTEKPE 142
KK + P + + +++E E + S LGA +S + + K TEK
Sbjct: 74 KKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAG 133
Query: 143 ETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFF 202
+T P +G+ V ++ EPS A + T E GS F
Sbjct: 134 KT-------GNSMPHPATGKTVANLLSGKSPRKSAEPS--ANTTLVSETEEEGSV-PAFG 183
Query: 203 TQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQE 262
G ED +S+ +T+ +GK V ++ AS + +
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSD----------ETDVEGKPSVKPAQVKASSVSTKES 233
Query: 263 PAESAH---------EPRLSA----EYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK 309
PA A P++ ++ + P EE S +G E+ AP T +
Sbjct: 234 PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGT-----R 288
Query: 310 IEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLK 369
+V E + +V ++ + K G A + ++ + +P ++
Sbjct: 289 SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGA-----VASQTKAGKPEEDSESSS 343
Query: 370 ETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLS--SQERMKVQGSPLKKLFTSTGL 427
E E+ T A + +L G S+V S ++E + +P T +
Sbjct: 344 EESSDSEEETPAA-----KALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAV 398
Query: 428 KKLSGKKQKGKRGGGDEESGEHTQVPADS-PDSQEEQKGESSASSPEEPEEITC----LE 482
K K++ EES + PA + P + Q +SA + E P + +
Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458
Query: 483 KGLAEVQ-QDGEAEEGATSDGEKK---RE-------------------------GVTPWA 513
G A Q Q G+ EE + S E+ RE G+ P
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLG 518
Query: 514 SFKKMVTP-KKRVRRPS------ESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEP 566
V P K PS E D E ++ ++ + + QE+ G++ +
Sbjct: 519 KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQA 578
Query: 567 KPEE------PKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQK----- 615
KP P++ +V +A + +S+ S+D E P AM K
Sbjct: 579 KPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKI 638
Query: 616 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 675
K+T T A ++ G+ +P +AG+ T G S + P + S
Sbjct: 639 PQTKACPKKTNT---TASAKVAPVRVGTQAPRKAGTATSPAGSSPAVA-GGTQRPAEDSS 694
Query: 676 SKLEEKSEDSIAGSGVE-----------HSTPDTEPGKEESWVSIKKFIPGRRKKRPDGK 724
S E SE+ G V + P K +PG K P
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG--KTGPTVT 752
Query: 725 QEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK 784
Q +A ++ + E DS+ A P +V++ + +A A +A P K
Sbjct: 753 QVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGT----- 805
Query: 785 ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQ------------------ 826
+A AA ++RSPS + V P
Sbjct: 806 ----------ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 855
Query: 827 VEAEAALLTEE---VLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPE---AVTA 880
A+A EE E E +EEE T+ + P + + ++ A+ +P A T
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP 915
Query: 881 AETAGPLGAEEGTE---ASAAEETTEMVSAVSQLTDS-----------PDTT---EEATP 923
GP A+ G + S++EE+ A + +T + P+ + ATP
Sbjct: 916 PGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATP 975
Query: 924 VQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTG------GPEDVLQPVQRAEAE 977
Q P + R ++ ++ + + ++E +P T V P
Sbjct: 976 AQAQAASTP---RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIA 1032
Query: 978 RPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSEL 1037
A AS K+ + + + T+ + + T+P+S + T + +L
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKL 1092
Query: 1038 VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDA------PGTTQK- 1090
QA T A S + DS ++ + SE DG P A P T+
Sbjct: 1093 PEVQQA-TKAPESSDD-------SEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETL 1144
Query: 1091 -DEIVEIHEENEVASGTQ---SGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE 1146
+E E++V + +Q SG PA + A +D +
Sbjct: 1145 VEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPD 1204
Query: 1147 HTDKEVSVETVSILSKTEGTQEA 1169
+ + +LS G +EA
Sbjct: 1205 GKQEAKPQQAAGMLSPKTGGKEA 1227
Score = 65.9 bits (159), Expect = 3e-10
Identities = 273/1431 (19%), Positives = 471/1431 (32%), Gaps = 189/1431 (13%)
Query: 401 EVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQ 460
EV+ S Q+ Q L ++T G+K+K + + P + +S
Sbjct: 29 EVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESS 88
Query: 461 EEQKGESSASSPEEPE-------------EITCLEKGLAEVQQDGEAEEGATSDGEKKR- 506
EE++ + ++ P + EK AE ++ G+ K
Sbjct: 89 EEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTV 148
Query: 507 EGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTEST--ASEMQEEMKGSVE 564
+ S +K P SE+++E + +A S A E+ S +
Sbjct: 149 ANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSD 208
Query: 565 EPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKE 624
E E V ++ S ++A + P+ GG A A K +E
Sbjct: 209 ETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEE 268
Query: 625 TGTDGILAGSQEHDPGQGSSSPEQAGSP-------------TEGEGVSTWESFKRLVTPR 671
E + G+ S +A T G+G + K
Sbjct: 269 ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVAS 328
Query: 672 KKSKSKLEEKSEDSI-AGSGVEHSTPDTE---PGKEESWVSIKKFIPGRRKKRPDGKQEQ 727
+ K EE SE S S E TP + K S K+ P
Sbjct: 329 QTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP 388
Query: 728 APVEDAGP------TGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATE 781
AP GP G E+DS S + + E+ QA+ S + P+ +AA+
Sbjct: 389 APPGKTGPAVAKAQAGKREEDSQ-------SSSEESDSEEEAPAQAKPSGKAPQVRAASA 441
Query: 782 VSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLER 841
+KE S + A G AA + + +S E EA AA+ +V
Sbjct: 442 PAKE-SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500
Query: 842 EVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEA-VTAAETAGPLGAEEGTEASAAEE 900
+ +P + P + A TP A V E +EE +++S E
Sbjct: 501 GKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEV 560
Query: 901 TTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEES---- 956
T + A + S +A P G P ++ +Q AEK + S
Sbjct: 561 PTAVAPAQEK---SLGNILQAKPTSSPAKGPP-----QKAGPVAVQVKAEKPMDNSESSE 612
Query: 957 QLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQ 1016
+ + E+ + A+A+ + + K+T+ + K
Sbjct: 613 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTA 672
Query: 1017 TTPESFEKA-----PQVTESIESSELVTTCQAET-LAGVKSQEMVMEQAIPPDSVETPT- 1069
T+P A + E SSE + + +T LA Q + + + + P
Sbjct: 673 TSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVK 732
Query: 1070 DSETDGSTPV-ADFDAPGTTQ-KDEIVEIHEENEVASGTQSGG------------TEAEA 1115
S G+ PV P TQ K E E E +E S ++ T+A+A
Sbjct: 733 GSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKA 792
Query: 1116 VPAQKERPPAPSSF---------VFQEETKEQSKMEDTLEHTDKEVSV----ETVSILSK 1162
PA P A + Q + + SK++ + + + +V + K
Sbjct: 793 NPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGK 852
Query: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEG-TEEAECKKDDA 1221
T Q E+ GS + E T +K G T + A
Sbjct: 853 AVATAAQAQTGPEED---------SGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 903
Query: 1222 LELQSHAKSPPSPVER-EMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTV 1280
E +P P + Q ++ + ++ E AVT ++ + L+
Sbjct: 904 KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLI--- 960
Query: 1281 NVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASF-TLTAAAEEEKVLGETANI 1339
+D + + +P Q +A T + ++SE++ + ++ +E+E V+ T +
Sbjct: 961 ---FVDPNRSPAGPAATP----AQAQAASTPRKARASESTARSSSSESEDEDVIPATQCL 1013
Query: 1340 -------LETGETLEP--------AGAHLVLEEK--SSEKNEDFAAHPGEDAVPTGPDCQ 1382
+ T T P AGA E S K ++ A + AV T P
Sbjct: 1014 TPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATS 1073
Query: 1383 AKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQ---------------------- 1420
+ST V T K E ++ T SD+ ++
Sbjct: 1074 PQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT 1133
Query: 1421 VACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQT 1480
+ + +E+ E+ ++ S L+ + + AT L S
Sbjct: 1134 LGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSV 1193
Query: 1481 QAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQA------------ 1528
+ + D D QE +PQ +A +P T KE + T ++
Sbjct: 1194 SSTLAAKDDPDGKQEA-----KPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQA 1248
Query: 1529 -----HSDISKDMSEASEKTMTVEVEGSTVN------DQQLEEVVLPSEEEG--GGAGTK 1575
S+I++ + +V+ S V +Q+ ++VV ++E G K
Sbjct: 1249 STLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRK 1308
Query: 1576 SVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNS---ALADTDASGGLTKESPDT 1632
D A R +K + E G+ PE ++ A D + G KE
Sbjct: 1309 RKLSGDQPAARTPRSKKK-KKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGK 1367
Query: 1633 NGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTE 1683
+ +D E ELQ+G E P++++E +K ++ E E
Sbjct: 1368 GSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKE 1418
Score = 58.2 bits (139), Expect = 7e-08
Identities = 205/1036 (19%), Positives = 358/1036 (34%), Gaps = 169/1036 (16%)
Query: 118 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEK 177
K +GA A +KES K + P + A+ E Q+ E + +E+
Sbjct: 367 KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQS----SSEESDSEEE 422
Query: 178 EPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKV 237
P+++ S +P + K+ +G A + + + +V E+ E+
Sbjct: 423 APAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES 482
Query: 238 DTEEDGKAEVASEKLTASEQAHPQEPAE---------------------SAHEPRLSAEY 276
D++ + A + + ++ ++ +PA + ++
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWE 542
Query: 277 EKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAE--------VHVSTVEE 328
E E SEE S G AP + ++ A+ V V E
Sbjct: 543 EDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 602
Query: 329 RTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSP-- 386
+ + EE++ S +EE Q A+PA ++ + K C + T A ++P
Sbjct: 603 KPMDNSESSEESSDSADSEEAPAAMTAAQ-AKPALKIPQTK-ACPKKTNTTASAKVAPVR 660
Query: 387 -----DEKV----------------LSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTST 425
K +P E S E S +E+ + + +
Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
Query: 426 GLK-KLSGKKQKGKRGGG------DEESGEHTQVPA----DSPDSQEEQKGESSASSPEE 474
GL+ K + KG G G + TQV A DS S+EE E +A+SP +
Sbjct: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
Query: 475 PEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKR--VRRPSESD 532
+ T ++K A+ A + VT A K+ K + VR P S
Sbjct: 781 VK--TSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNST 838
Query: 533 KEDELDKVKSATLSSTESTASEMQ---EEMKGSVEEPKPEEPKRKVDTSV-----SWEAL 584
++ +TA++ Q EE GS EE E + + V + +
Sbjct: 839 VLAR-GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIR 897
Query: 585 ICVGSSKKRARRGSSSDEEG--GPKAMGGDHQKADEAGKDKETGTDGILAGSQEH----- 637
+ +K+ R+G++ G GP A Q D +E+ +DG +
Sbjct: 898 AALAPAKESPRKGAAPTPPGKTGPSAAQAGKQD-DSGSSSEESDSDGEAPAAVTSAQVIK 956
Query: 638 ------DPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGS-- 689
DP + + P A +P + + ST + + + S S E + ED I +
Sbjct: 957 PPLIFVDPNRSPAGP--AATPAQAQAASTPRKARASESTARSSSS--ESEDEDVIPATQC 1012
Query: 690 ---GVEHST-------PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDA-GPTGA 738
G+ + P P + S K + DGK+++ P G
Sbjct: 1013 LTPGIRTNVVTMPTAHPRIAPKASMAGASSSK----ESSRISDGKKQEGPATQVDSAVGT 1068
Query: 739 NEDDSDVPAVVPLSEYDAVEREKM-EAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAA 797
S V + + + K+ E QQA K+ E + + S SE A
Sbjct: 1069 LPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGA 1128
Query: 798 VADGT------RAATIIEER------------SPSWISASVTEPLEQVEAEAALLTEEV- 838
+ T R T++EE S S +S +T L ++A+ T ++
Sbjct: 1129 KSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLD 1188
Query: 839 ----LEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTE 894
+ + A+++P E P+ E T ++ P +
Sbjct: 1189 SSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKE-AASGTTPQKSRKPKKGAGNPQ 1247
Query: 895 ASAAEETTEMVSAVSQ-LTDSPDTTEEATPVQEVEGGVPDIEEQERR-----TQEVLQ-- 946
AS T + S ++Q L P EA V + ++ EQER+ T+E +
Sbjct: 1248 AS----TLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKG 1303
Query: 947 --------------AVAEKVKEESQL-PGTGGPEDVLQPVQRAEAERPEEQAEASGLKKE 991
A + K++ +L G GG V ++ ++ +ASG KE
Sbjct: 1304 WESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKE 1363
Query: 992 TDVVLKVDAQEAKTEP 1007
+ +Q AK EP
Sbjct: 1364 KKGKGSLGSQGAKDEP 1379
Score = 57.0 bits (136), Expect = 2e-07
Identities = 211/1064 (19%), Positives = 369/1064 (34%), Gaps = 224/1064 (21%)
Query: 54 SESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAG 113
S+S+ E L +Q +G K + + T+ + + K G G
Sbjct: 482 SDSDREALAAMNAAQVKPLG--------------KSPQVKPASTMGMGPLGKGAGPVPPG 527
Query: 114 AGDHKDPSLGAG------EAASKESEPKQSTEKPEETLKREQ------------SHAEIS 155
PS G E++S+ES E P ++ S
Sbjct: 528 KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG 587
Query: 156 PPAESGQAVEECKEE---GEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKK 212
PP ++G + K E + +E S SA+S +P Q +
Sbjct: 588 PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAA--------QAKPALKIP 639
Query: 213 TSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRL 272
+ PK+ AS K P +V T+ KA A+ +S PA + R
Sbjct: 640 QTKACPKKTNTTASAKVA---PVRVGTQAPRKAGTATSPAGSS-------PAVAGGTQR- 688
Query: 273 SAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK-----IEVHQEEV-----VAEVH 322
P+E+ S + SEE+ LA V K ++V V + +
Sbjct: 689 ---------PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT 739
Query: 323 VSTVEERTEEQKTEV--EETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQ 380
+ +T T+V E+ S +EE E D+E A PA+ +K+T
Sbjct: 740 APVLPGKTGPTVTQVKAEKQEDSESSEE--ESDSEEAAASPAQVKTSVKKTQAKANP--- 794
Query: 381 GADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKK----------- 429
A +P K P VV+ + KV+ P++ ST L +
Sbjct: 795 AAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVK-PPVRNPQNSTVLARGPASVPSVGKA 853
Query: 430 --LSGKKQKGKR---GGGDEESGEHTQVPADS---PDSQEEQKGESSASSPEEPEE---I 478
+ + Q G G +EES + + P + Q + A + E P +
Sbjct: 854 VATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAP 913
Query: 479 TCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMV------------TPKKRVR 526
T K Q G+ ++ +S E +G P A V +P
Sbjct: 914 TPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAA 973
Query: 527 RPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTS------VS 580
P+++ K + A+ S+ S++SE ++E + + V T ++
Sbjct: 974 TPAQAQAASTPRKAR-ASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIA 1032
Query: 581 WEALICVGSSKKRARRGSSSDEEGGP-----KAMGGDHQKADEAGKDKETGTDGI----- 630
+A + SS K + R S ++ GP A+G + ++ + GT+ +
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKL 1092
Query: 631 -----LAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEE----K 681
+ E SS +GS +GEG +S L ++++ +EE
Sbjct: 1093 PEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAES 1152
Query: 682 SEDSIAGSGVE----HSTPDTEPGKEESWVSIKKFIPG-------RRKKRPDGKQEQAPV 730
SED + + TP P ++ + K K PDGKQE P
Sbjct: 1153 SEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQ 1212
Query: 731 EDAG----PTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKEL 786
+ AG TG E S ++++ +K A P+
Sbjct: 1213 QAAGMLSPKTGGKEAASGT--------------TPQKSRKPKKGAGNPQ----------- 1247
Query: 787 SESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLE--QVEAEAALLTEEVLEREVI 844
A+T+ + + + PL QV+A + E+LE+E
Sbjct: 1248 -----------------ASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQE-- 1288
Query: 845 AEEEPPTVTEPLPENREARGDTVVSE--AELTPEAVTAAETAGPLGAEEGTEASAAEETT 902
++ T E + E+R + + A TP ++ LGA EG EAS + E T
Sbjct: 1289 RKKVVDTTKESSRKGWESRKRKLSGDQPAARTPR----SKKKKKLGAGEGGEASVSPEKT 1344
Query: 903 EMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQL-PGT 961
TT + ++ G D++E++ + Q ++ +EE Q GT
Sbjct: 1345 -------------STTSKGKAKRDKASG--DVKEKKGKGSLGSQGAKDEPEEELQKGMGT 1389
Query: 962 GGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKT 1005
D P + E ++ +++ + K++ K +++++
Sbjct: 1390 VEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSES 1433
Score = 35.4 bits (80), Expect = 0.47
Identities = 29/140 (20%), Positives = 57/140 (40%), Gaps = 17/140 (12%)
Query: 118 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEE-CKEEGEEKQE 176
K LGAGE P++++ + KR+++ ++ G + K+E EE+ +
Sbjct: 1325 KKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ 1384
Query: 177 KEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEK 236
K S S+ ++K K K+D+ + +KKK ++
Sbjct: 1385 KGMGTVEGGDQSNPKSK----------------KEKKKSDKRKKDKEKKEKKKKAKKAST 1428
Query: 237 VDTEEDGKAEVASEKLTASE 256
D+E + + +K TA +
Sbjct: 1429 KDSESPSQKKKKKKKKTAEQ 1448
>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
Length = 3664
Score = 86.7 bits (213), Expect = 2e-16
Identities = 245/1245 (19%), Positives = 409/1245 (32%), Gaps = 175/1245 (14%)
Query: 17 VSKRDSDKEMATKSA----VVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDI 72
+ KRDS ++ + + V D +DG+ ++ S L L + E + +
Sbjct: 1359 IIKRDSLRKRSVRDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRER 1418
Query: 73 GFKKVFKFVGFKF-TVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKD-PSLGAGEAASK 130
+ KF + DKT PDT LL K D S A +K
Sbjct: 1419 DERLSSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNK 1478
Query: 131 ESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQE-------------- 176
+ E S +P + ++ + E+ KEE +E+QE
Sbjct: 1479 DKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQ 1538
Query: 177 ------------------------KEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKK 212
K+ S+ A S T + +F ++K
Sbjct: 1539 DSKRLQHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEK 1598
Query: 213 TSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRL 272
+KPKE E + + + PE +D + + S E A SA E
Sbjct: 1599 EKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTT 1658
Query: 273 SAEYEKVELPSEEQVSGSQGPSEE-----KPAPLATEVFDEKIEV----HQEEVVAEVHV 323
+ + L +EE+ SEE +PAP E E++++ ++ A +
Sbjct: 1659 GDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQL-EQVDLPPGADPDKEAAMMPA 1717
Query: 324 STVEERTEEQKTEVE---ETAGSVPAEELVEMDAEPQEAEPAKELVKLKETC--VSGEDP 378
E + +Q ++ T G+ ++ +D EP +P + + E E P
Sbjct: 1718 GVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKP 1777
Query: 379 TQGADLSPDEKVL------SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSG 432
AD PD S+PP EV+ + + K S K +
Sbjct: 1778 DATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVE 1837
Query: 433 KKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGE----------SSASSPEEPEEITCLE 482
K K D E + + P E K E +SA+ E PE
Sbjct: 1838 KPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEP----S 1893
Query: 483 KGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKS 542
L+ ++ AT + R V K+ V +P + K E + ++
Sbjct: 1894 LPLSRTRRRNVRSVYATMGDHENRSPV------------KEPVEQPRVTRKRLERELQEA 1941
Query: 543 ATLSSTESTASEMQEEMKGSVEEP-KPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSD 601
A + +T + + EE + +EP + W R+ R +
Sbjct: 1942 AAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGW-----------RSPRSQKTA 1990
Query: 602 EEGGPKAMGGDHQKADEAGKDK---ETGTD-GILAGSQEHDPGQGSSSPEQ------AGS 651
GGP+ G ++ +A + + E G G+ S E + + EQ AG+
Sbjct: 1991 AGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGT 2050
Query: 652 PTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKK 711
+ E ++ P K SKSK +A K S ++
Sbjct: 2051 DKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLA------------VDKSASLKNVDA 2098
Query: 712 FIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVP----AVVPLSEYDAVEREKMEAQQA 767
+ P G QA ++G + + S+ P + + D V+ +K E ++
Sbjct: 2099 AV------SPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDK-EPEKE 2151
Query: 768 QKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQV 827
SA P + AT+++K++ Q A +A+ + +A + +P Q
Sbjct: 2152 DVSASGPSPE-ATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQA 2210
Query: 828 -EAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGP 886
E E A ++ ++ E E P P S+ +L P A A
Sbjct: 2211 SETELAAAIGSII-NDISGEPENFPAPPPYPGE---------SQTDLQPPAGAQALQPSE 2260
Query: 887 LGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEE---QERRTQE 943
G E S ET + ++PD + T +E G + + + ++E
Sbjct: 2261 EGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKE 2320
Query: 944 VLQAVAEKVKEESQLPGT----GGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVD 999
V + K K + + + V+ PV+ E + Q E+ + T V
Sbjct: 2321 VEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEA 2380
Query: 1000 AQEAKTEPFTQGKVVGQTTPES----FEKAPQVTESIESSELVTTCQAETLAGVKSQEMV 1055
QE K Q + T P+S K P S S E+ + T A V
Sbjct: 2381 PQEEK-----QSEKPHSTPPQSCTSDLSKIPSTENS--SQEISVEERTPTKASVPPD--- 2430
Query: 1056 MEQAIPPDSVETPTDSETDGSTPVADF--DAPGTTQKDEIVEIHEENEVASGTQSGGTEA 1113
+PP P D E V P T D + I V + S +
Sbjct: 2431 ----LPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVAS 2486
Query: 1114 EAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVS 1158
+P Q QEE + QS L K V+T S
Sbjct: 2487 GGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSS 2531
Score = 70.9 bits (172), Expect = 1e-11
Identities = 354/1845 (19%), Positives = 648/1845 (35%), Gaps = 292/1845 (15%)
Query: 18 SKRDSDKE---MATKSAVVHDITDDGQEETPEIIEQIPS-SESNLEELTQPTESQANDIG 73
S RD D E + + VH +P E++PS SE L + + +
Sbjct: 711 SDRDRDHERRPIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLS 770
Query: 74 ---FKKVFKFVGFKFTVKKDKTEKPDT------------VQLLTVKKDEGEGAAGAGDHK 118
++K+ K ++T K +KT+K T ++ V+KD+ + G
Sbjct: 771 PPRYEKLDKSRLERYT-KNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVH 829
Query: 119 DPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEEC------KEEGE 172
PS + E +E+E +QS EKP K + A+ A++ + C KE+
Sbjct: 830 SPSSQSSET-DQENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEG 888
Query: 173 EKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTS------FRKPKE----DE 222
+ + P + ++ T ++ + +K + S + PKE
Sbjct: 889 KVIDHTPVEKLKAKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLSSH 948
Query: 223 VEASEKK---KEQEPEKVDTEEDGKAEVASEKLTASEQ--------AHPQEPAESAHEPR 271
VE EK+ K ++ K + DG + V EKL A ++ A Q+P P
Sbjct: 949 VEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPE 1008
Query: 272 LS----AEYEKVELPSEEQVSGSQGPSEEKPAPLATEVF---DEKIEVHQEEVVAE---- 320
+ ++ ++ S E + +G +E KP + E+ +KI++ + VA
Sbjct: 1009 MEDARVLSKKQPDVSSREVILLREGEAERKP--VRKEILKRESKKIKLDRLNTVASPKDC 1066
Query: 321 -----VHVSTVEERTEEQKTEVEETAG-SVPAEELVEMDAEPQEAE-----------PAK 363
+ V + + + + + E AG SV +E+ P + + P +
Sbjct: 1067 QELASISVGSGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPER 1126
Query: 364 ELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFT 423
E V+ + E P + + V ++ G+ +++ S + Q +++
Sbjct: 1127 EDVRKNYCSLRDETPERKSGQEKSHSVNTEEKIGI--DIDHTQSYRKQMEQSRRKQQMEM 1184
Query: 424 STGLKKLSGKKQKG----KRGGGDEESGEHTQ-VPADSPDSQEEQ----------KGESS 468
+ G +K +R E G+ Q V DSP S++++ K E +
Sbjct: 1185 EIAKSEKFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERN 1244
Query: 469 ASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRP 528
S + E + G V+ G E G + V + V P +
Sbjct: 1245 YRSSRQISEDSERTGGSPSVRH-GSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITVR 1303
Query: 529 SESDKEDELDKVKSATLSS-TESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICV 587
ES K + D + ++ + S + E + + + + ++ + D S ++I
Sbjct: 1304 EESLKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFP-NSIIKR 1362
Query: 588 GSSKKRARRG-------SSSDEEGGPKAMGGDHQKADEAGK---------DKETGTDGIL 631
S +KR+ R S SDE+G K+ E+ + DK D L
Sbjct: 1363 DSLRKRSVRDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERL 1422
Query: 632 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 691
+ S E + + + T+ + E K L + R+++ S L+ S + +
Sbjct: 1423 SSSLERNKFYSFALDKTITPDTK----ALLERAKSLSSSREENWSFLDWDSRFANFRNNK 1478
Query: 692 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVED------------------- 732
+ D+ P SW KK I + + D K+E E+
Sbjct: 1479 DKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQ 1538
Query: 733 -------------------------AGPTGANE--DDSDVPAVVPLSEYDAVEREKMEAQ 765
GAN D P V+ S + + R + + +
Sbjct: 1539 DSKRLQHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEK 1598
Query: 766 QAQKSAEQPEQKAATE----VSKELSESQVHMMAAAVADGTRAATIIE-ERSPSWISASV 820
+ + ++ E++ TE + E++ + + G + T++ E +PS + +
Sbjct: 1599 EKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTT 1658
Query: 821 TEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTA 880
+ EA L+TEE EE +EP P E + + +L P A
Sbjct: 1659 GDK----TVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQ-----LEQVDLPPGADPD 1709
Query: 881 AETA-GPLGAEEGT--------EASAAEETTEMVSAVSQLTDSPDTTEE-ATPVQEVEGG 930
E A P G EEG+ +A A S + PD+T+ + P Q+ E
Sbjct: 1710 KEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEA 1769
Query: 931 VPDIEEQERRTQEVLQAVAEKVK--EESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGL 988
E+ T + +K + ESQ P + E + P A+ ++P + +
Sbjct: 1770 NEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLE--VDPPVAAKDKKPNKSKRSKTP 1827
Query: 989 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAG 1048
+ V + K+E + K+ +P E + +E+ ++ T + A
Sbjct: 1828 VQAAAVSIVEKPVTRKSERIDREKLKRSNSPRG-EAQKLLELKMEAEKITRTASKNSAAD 1886
Query: 1049 VKSQEMVMEQAIPPDSVET-------PTDSETDGSTPVAD-FDAPGTTQKDEIVEIHEEN 1100
++ E ++P T + + +PV + + P T+K E
Sbjct: 1887 LEHP----EPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRK------RLER 1936
Query: 1101 EVASGTQSGGTEAEAVPA--QKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVS 1158
E+ EA AVP ++ RPP +EE E + +TL+ + S
Sbjct: 1937 EL--------QEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRS----- 1983
Query: 1159 ILSKTEGTQEADQYADEKTKDVPFFEGL--EGSIDTG--ITVSREKVTEVALKGE-GTEE 1213
+++ T +K K+ P + E + + G I V + A + E G+E+
Sbjct: 1984 --PRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQ 2041
Query: 1214 AECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVS 1273
+KD + K+PP V+V +K E ++ + + V + S
Sbjct: 2042 KRDRKDAGTD-----KNPPETAP----VEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSAS 2092
Query: 1274 KQLLQTVNVP----IIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE 1329
+ + P G +E + SP ++ Q++S E+
Sbjct: 2093 LKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKED 2152
Query: 1330 EKVLGET--ANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTP 1387
G + A L LE A H+ ++S + + A E P D A
Sbjct: 2153 VSASGPSPEATQLAKQMELEQAVEHIAKLAEAS-ASAAYKADAPEGLAPEDRDKPAHQAS 2211
Query: 1388 VIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETK 1447
A + +D+ GE E + DL+P G L+
Sbjct: 2212 ETELAAAIGSIINDISGE------------PENFPAPPPYPGESQTDLQPPAGAQALQPS 2259
Query: 1448 SSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAH--VIKADSQDAGQETEKEGEEPQA 1505
++ + T+E + +L +E T++ + A AG KE +
Sbjct: 2260 -------------EEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSS 2306
Query: 1506 SAQDETPITSAKEESESTAV----GQAHSDISKDMSEASEKTMT-VEVEGSTVNDQQLEE 1560
P +E E T V G+ + S+ ++K + VE N Q E
Sbjct: 2307 ETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGES 2366
Query: 1561 VVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTD 1620
P+ EG P+++ ++ EK P + D P +NS+ +
Sbjct: 2367 ---PAANEGTTVQHPEAPQEE------KQSEKPHSTPPQSCTSDLSKIPSTENSSQEISV 2417
Query: 1621 ASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHS--ESDKAITP 1663
TK S + P + E +VHS ESD P
Sbjct: 2418 EERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPP 2462
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 86.7 bits (213), Expect = 2e-16
Identities = 302/1564 (19%), Positives = 543/1564 (34%), Gaps = 263/1564 (16%)
Query: 209 WRKKTSF-RKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESA 267
W++ + RK K +E A + KK + + + T E + E +E TA +A P+ S
Sbjct: 53 WQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETA--KATPR--LAST 108
Query: 268 HEPRLSAEYE---KVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVS 324
+ L A+ K + +E + +G G S PA T + ++ + +
Sbjct: 109 NSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
Query: 325 TVEERTEE------------------QKTEVEETAGSVPAEELVEMDAEPQEAEPAKELV 366
V E EE Q E S E VE + A+ V
Sbjct: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV 228
Query: 367 KLKETCVSGEDPTQG--ADLSPDEKVLSKPP---------------EGVVSEVEM-LSSQ 408
KE+ P G D++P K + PP EG SE E ++
Sbjct: 229 STKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTR 288
Query: 409 ERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESS 468
++K L+ S K GK G G+ V + + + E+ ESS
Sbjct: 289 SQVKASEKILQVRAASAPAKGTPGK------GATPAPPGKAGAVASQTKAGKPEEDSESS 342
Query: 469 ASSPEEPEEITCLEKGLAEVQQDGEAEE-GATSDGEKK--REGVTPWASFKKMVTPKKRV 525
+ + EE T K L + + G+ + GA S K+ R+G P K K
Sbjct: 343 SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQ 402
Query: 526 RRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWE--- 582
E D + ++ S + ++ S +++ + P E P++ + +
Sbjct: 403 AGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA-SAPAKESPRKGAAPAPPRKTGP 461
Query: 583 --ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPG 640
A + VG ++ +R S + + + GK + + G G
Sbjct: 462 AAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM-GMGPLGKG 520
Query: 641 QGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDT-E 699
G P + G T V WE + S+S EE S+ S + P
Sbjct: 521 AGPVPPGKVGPATPSAQVGKWE---------EDSESSSEESSDSS------DGEVPTAVA 565
Query: 700 PGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVER 759
P +E+S +I + +P + P + AGP V A P+ ++ E
Sbjct: 566 PAQEKSLGNILQ-------AKPTSSPAKGPPQKAGPVAVQ-----VKAEKPMDNSESSEE 613
Query: 760 EK-----------MEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATII 808
M A QA+ + + P+ KA + + + ++V + +A T
Sbjct: 614 SSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT 673
Query: 809 EERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVV 868
SP+ S +V ++ +++ E +EEE + + + + V
Sbjct: 674 ---SPAGSSPAVAGGTQRPAEDSSS------SEESDSEEEKTGLAVTVGQAKSVGKGLQV 724
Query: 869 SEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVE 928
A + + TA L + G T V A Q + +++EE + +E
Sbjct: 725 KAASVPVKGSLGQGTAPVLPGKTGP-------TVTQVKAEKQ--EDSESSEEESDSEEAA 775
Query: 929 GGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT-GGPEDVLQPVQRAEAERPEEQAEASG 987
++ ++TQ A + GT P V+ +A+ P +
Sbjct: 776 ASPAQVKTSVKKTQAKANPAAARAPSAK---GTISAPGKVVTAAAQAKQRSPSKVKPPVR 832
Query: 988 LKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLA 1047
+ + V+ + A QT PE E + E +S E +AETLA
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPE--EDSGSSEEESDSEE-----EAETLA 885
Query: 1048 GVKSQEMV--MEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASG 1105
VK + A+ P +S G+ P PG T +++ +S
Sbjct: 886 QVKPSGKTHQIRAALAPAK-----ESPRKGAAPTP----PGKTGPSAAQAGKQDDSGSSS 936
Query: 1106 TQS---GGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK 1162
+S G A AQ +PP +F + + + T + T
Sbjct: 937 EESDSDGEAPAAVTSAQVIKPP----LIFVDPNRSPAGPAATPAQAQ---AASTPRKARA 989
Query: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1222
+E T + E +P + L I T + +A K + K+ +
Sbjct: 990 SESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRI 1049
Query: 1223 ELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNV 1282
+ +K E T V ++AV S Q
Sbjct: 1050 S--------------------DGKKQEGPATQV-------DSAVGTLPATSPQSTSVQ-- 1080
Query: 1283 PIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILET 1342
AK + L P + ++A SE S ++ +EE+ GE ++
Sbjct: 1081 -----AKGTNKLRKPKLPEV--QQATKAPESSDDSEDSSDSSSGSEED---GEGPQGAKS 1130
Query: 1343 GETL---EPAGAHLVLEEKSSEKNEDFAAHPGEDAVP-------TGPDCQA-KSTPVIVS 1391
TL P+ ++EE ++E +ED P + + T + QA K+TP + S
Sbjct: 1131 AHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDS 1190
Query: 1392 A---TTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIE-DLEPENGILELETK 1447
+ ++ D +G++ + + + + +E + +P+ G +
Sbjct: 1191 SPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQAS 1250
Query: 1448 SSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASA 1507
+ L NI Q + Q +E Q QA V+K ++ QE +K + + S+
Sbjct: 1251 TLALQSNITQCLLGQ---------PWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESS 1301
Query: 1508 QDETPITSAKEESESTAVGQAHSDISKDMS-----EAS---EKTMTVEVEGSTVNDQQLE 1559
+ K + A S K + EAS EKT T +G D+
Sbjct: 1302 RKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTS-KGKAKRDKASG 1360
Query: 1560 EVVLPSEEEGGGA----GTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSA 1615
+V E++G G+ G K PE E ++K + +G D +P+++
Sbjct: 1361 DV---KEKKGKGSLGSQGAKDEPE--------EELQKGM----GTVEGGDQSNPKSK--- 1402
Query: 1616 LADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERE 1675
K+K+K D ++ + ++ + ++ KA T ++ QK++++
Sbjct: 1403 --------------------KEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKK 1442
Query: 1676 SAKS 1679
K+
Sbjct: 1443 KKKT 1446
Score = 80.5 bits (197), Expect = 1e-14
Identities = 242/1224 (19%), Positives = 414/1224 (33%), Gaps = 211/1224 (17%)
Query: 88 KKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPS-----LGAGEAASKESEPKQSTEKPE 142
KK + P + + +++E E + S LGA +S + + K TEK
Sbjct: 74 KKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAG 133
Query: 143 ETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFF 202
+T P +G+ V ++ EPS A + T E GS F
Sbjct: 134 KT-------GNSMPHPATGKTVANLLSGKSPRKSAEPS--ANTTLVSETEEEGSV-PAFG 183
Query: 203 TQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQE 262
G ED +S+ +T+ +GK V ++ AS + +
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSD----------ETDVEGKPSVKPAQVKASSVSTKES 233
Query: 263 PAESAH---------EPRLSA----EYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK 309
PA A P++ ++ + P EE S +G E+ AP T +
Sbjct: 234 PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGT-----R 288
Query: 310 IEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLK 369
+V E + +V ++ + K G A + ++ + +P ++
Sbjct: 289 SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGA-----VASQTKAGKPEEDSESSS 343
Query: 370 ETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLS--SQERMKVQGSPLKKLFTSTGL 427
E E+ T A + +L G S+V S ++E + +P T +
Sbjct: 344 EESSDSEEETPAA-----KALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAV 398
Query: 428 KKLSGKKQKGKRGGGDEESGEHTQVPADS-PDSQEEQKGESSASSPEEPEEITC----LE 482
K K++ EES + PA + P + Q +SA + E P + +
Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458
Query: 483 KGLAEVQ-QDGEAEEGATSDGEKK---RE-------------------------GVTPWA 513
G A Q Q G+ EE + S E+ RE G+ P
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLG 518
Query: 514 SFKKMVTP-KKRVRRPS------ESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEP 566
V P K PS E D E ++ ++ + + QE+ G++ +
Sbjct: 519 KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQA 578
Query: 567 KPEE------PKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQK----- 615
KP P++ +V +A + +S+ S+D E P AM K
Sbjct: 579 KPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKI 638
Query: 616 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 675
K+T T A ++ G+ +P +AG+ T G S + P + S
Sbjct: 639 PQTKACPKKTNT---TASAKVAPVRVGTQAPRKAGTATSPAGSSPAVA-GGTQRPAEDSS 694
Query: 676 SKLEEKSEDSIAGSGVE-----------HSTPDTEPGKEESWVSIKKFIPGRRKKRPDGK 724
S E SE+ G V + P K +PG K P
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG--KTGPTVT 752
Query: 725 QEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK 784
Q +A ++ + E DS+ A P +V++ + +A A +A P K
Sbjct: 753 QVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGT----- 805
Query: 785 ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQ------------------ 826
+A AA ++RSPS + V P
Sbjct: 806 ----------ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 855
Query: 827 VEAEAALLTEE---VLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPE---AVTA 880
A+A EE E E +EEE T+ + P + + ++ A+ +P A T
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP 915
Query: 881 AETAGPLGAEEGTE---ASAAEETTEMVSAVSQLTDS-----------PDTT---EEATP 923
GP A+ G + S++EE+ A + +T + P+ + ATP
Sbjct: 916 PGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATP 975
Query: 924 VQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTG------GPEDVLQPVQRAEAE 977
Q P + R ++ ++ + + ++E +P T V P
Sbjct: 976 AQAQAASTP---RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIA 1032
Query: 978 RPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSEL 1037
A AS K+ + + + T+ + + T+P+S + T + +L
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKL 1092
Query: 1038 VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDA-------PGTTQK 1090
QA T A S + DS ++ + SE DG P A P T+
Sbjct: 1093 PEVQQA-TKAPESSDD-------SEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTET 1144
Query: 1091 --DEIVEIHEENEVASGTQ---SGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTL 1145
+E E++V + +Q SG PA + A +D
Sbjct: 1145 LVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDP 1204
Query: 1146 EHTDKEVSVETVSILSKTEGTQEA 1169
+ + + +LS G +EA
Sbjct: 1205 DGKQEAKPQQAAGMLSPKTGGKEA 1228
Score = 69.7 bits (169), Expect = 2e-11
Identities = 256/1311 (19%), Positives = 459/1311 (35%), Gaps = 196/1311 (14%)
Query: 486 AEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSAT- 544
+E+ + +AEE A +K R V+ SE ++E E + K+
Sbjct: 57 SELGRKRKAEEDAALQAKKTR------------VSDPISTSESSEEEEEAEAETAKATPR 104
Query: 545 LSSTESTA------SEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGS 598
L+ST S+ S M+E+ K E+ + A + G S +++ S
Sbjct: 105 LASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPS 164
Query: 599 SS-------DEEGGPKAMGGDHQ-------KADEAGKDKETGTDGI-LAGSQEHDPGQGS 643
++ +EEG A G + +AD + +D + +D + G P Q
Sbjct: 165 ANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVK 224
Query: 644 SS-------PEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTP 696
+S P + +P G+ K P K K EE+SE S GS E P
Sbjct: 225 ASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAP 284
Query: 697 ---DTEPGKEESWVSIK------KFIPGR-RKKRPDGK------QEQA--PVEDAGPTGA 738
++ E + ++ K PG+ P GK Q +A P ED+ +
Sbjct: 285 AGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE 344
Query: 739 NEDDS--DVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAA----------------- 779
DS + PA L + A + + + E P + AA
Sbjct: 345 ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAG 404
Query: 780 -----TEVSKELSESQVHMMAAAVADG----TRAATIIEERSPSWISASVTEPLEQVEAE 830
++ S E S+S+ A A G RAA+ + SP A+ P + A
Sbjct: 405 KREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPR-KGAAPAPPRKTGPAA 463
Query: 831 AALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAE 890
A + + E + EE + E L A+ + ++ P + GPLG
Sbjct: 464 AQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG---MGPLGKG 520
Query: 891 EG-TEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVA 949
G T DS ++EE++ + E QE+ +LQA
Sbjct: 521 AGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQA-- 578
Query: 950 EKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFT 1009
+ + P G P+ + +AE+P + +E+S ++ +D +A A T
Sbjct: 579 ----KPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESS--EESSDSADSEEAPAAMTAAQA 632
Query: 1010 QGKV-VGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETP 1068
+ + + QT ++ K T S + + + QA AG + A+ + P
Sbjct: 633 KPALKIPQT--KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAV-AGGTQRP 689
Query: 1069 TDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVP-----AQKERP 1123
+ + ++ + G V + + V G Q +A +VP Q P
Sbjct: 690 AEDSSSSEESDSEEEKTGLA-----VTVGQAKSVGKGLQ---VKAASVPVKGSLGQGTAP 741
Query: 1124 PAPSS---FVFQEETKEQSKMEDTLEHTD-KEVSVETVSILSKTEGTQEADQYADEKTKD 1179
P V Q + ++Q E + E +D +E + + + + TQ A +
Sbjct: 742 VLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPS 801
Query: 1180 VPFFEGLEGSIDTGITVSREK-VTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVERE 1238
G + T ++++ ++V + + + S K+ + + +
Sbjct: 802 AKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQ 861
Query: 1239 MVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSP 1298
+ + +E E ++ + E ET V ++ P AKE S +G+
Sbjct: 862 TGPEEDSGSSEEE----SDSEEEAETLAQVKPSGKTHQIRAALAP----AKE-SPRKGAA 912
Query: 1299 PPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEK 1358
P G+ + Q S ++EE GE + + + ++P L+ +
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGS-----SSEESDSDGEAPAAVTSAQVIKPP---LIFVDP 964
Query: 1359 SSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVD 1418
+ + G A P QA STP A+ SS E E + + +
Sbjct: 965 N-------RSPAGPAATPA--QAQAASTPRKARASESTARSSSSESEDEDVIP-ATQCLT 1014
Query: 1419 EQVACQEVKVSVAIEDLEPENGILELET--KSSKLVQNIIQ----TAVDQFVRTEETATE 1472
+ V + A + P+ + + +SS++ Q T VD V T +
Sbjct: 1015 PGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSP 1074
Query: 1473 MLTS------------ELQTQAHVIKA--------DSQDAGQETEKEGEEPQASAQDETP 1512
TS +L KA DS D+ +E++GE PQ + T
Sbjct: 1075 QSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1134
Query: 1513 ITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGA 1572
+ +E T V + ++ S+D A +++ L + P
Sbjct: 1135 VGPTPSRTE-TLVEETAAESSEDDVVAPSQSL-------------LSGYMTPGLTPANSQ 1180
Query: 1573 GTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDT 1632
+K+ P+ D ++ S + K+D G P+ L + +GG S T
Sbjct: 1181 ASKATPKLDSSPSVS-----STLAAKDDPDGKQEAKPQQAAGML--SPKTGGKEAASGTT 1233
Query: 1633 NGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTE 1683
+K K+ A + + S + + Q + Q + S LTE
Sbjct: 1234 PQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTE 1284
Score = 66.6 bits (161), Expect = 2e-10
Identities = 274/1432 (19%), Positives = 471/1432 (32%), Gaps = 190/1432 (13%)
Query: 401 EVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQ 460
EV+ S Q+ Q L ++T G+K+K + + P + +S
Sbjct: 29 EVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESS 88
Query: 461 EEQKGESSASSPEEPE-------------EITCLEKGLAEVQQDGEAEEGATSDGEKKR- 506
EE++ + ++ P + EK AE ++ G+ K
Sbjct: 89 EEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTV 148
Query: 507 EGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTEST--ASEMQEEMKGSVE 564
+ S +K P SE+++E + +A S A E+ S +
Sbjct: 149 ANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSD 208
Query: 565 EPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKE 624
E E V ++ S ++A + P+ GG A A K +E
Sbjct: 209 ETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEE 268
Query: 625 TGTDGILAGSQEHDPGQGSSSPEQAGSP-------------TEGEGVSTWESFKRLVTPR 671
E + G+ S +A T G+G + K
Sbjct: 269 ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVAS 328
Query: 672 KKSKSKLEEKSEDSI-AGSGVEHSTPDTE---PGKEESWVSIKKFIPGRRKKRPDGKQEQ 727
+ K EE SE S S E TP + K S K+ P
Sbjct: 329 QTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP 388
Query: 728 APVEDAGP------TGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATE 781
AP GP G E+DS S + + E+ QA+ S + P+ +AA+
Sbjct: 389 APPGKTGPAVAKAQAGKREEDSQ-------SSSEESDSEEEAPAQAKPSGKAPQVRAASA 441
Query: 782 VSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLER 841
+KE S + A G AA + + +S E EA AA+ +V
Sbjct: 442 PAKE-SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500
Query: 842 EVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEA-VTAAETAGPLGAEEGTEASAAEE 900
+ +P + P + A TP A V E +EE +++S E
Sbjct: 501 GKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEV 560
Query: 901 TTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEES---- 956
T + A + S +A P G P ++ +Q AEK + S
Sbjct: 561 PTAVAPAQEK---SLGNILQAKPTSSPAKGPP-----QKAGPVAVQVKAEKPMDNSESSE 612
Query: 957 QLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQ 1016
+ + E+ + A+A+ + + K+T+ + K
Sbjct: 613 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTA 672
Query: 1017 TTPESFEKA-----PQVTESIESSELVTTCQAET-LAGVKSQEMVMEQAIPPDSVETPT- 1069
T+P A + E SSE + + +T LA Q + + + + P
Sbjct: 673 TSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVK 732
Query: 1070 DSETDGSTPV-ADFDAPGTTQ-KDEIVEIHEENEVASGTQSGG------------TEAEA 1115
S G+ PV P TQ K E E E +E S ++ T+A+A
Sbjct: 733 GSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKA 792
Query: 1116 VPAQKERPPAPSSF---------VFQEETKEQSKMEDTLEHTDKEVSV----ETVSILSK 1162
PA P A + Q + + SK++ + + + +V + K
Sbjct: 793 NPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGK 852
Query: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEG-TEEAECKKDDA 1221
T Q E+ GS + E T +K G T + A
Sbjct: 853 AVATAAQAQTGPEED---------SGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 903
Query: 1222 LELQSHAKSPPSPVER-EMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTV 1280
E +P P + Q ++ + ++ E AVT ++ + L+
Sbjct: 904 KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLI--- 960
Query: 1281 NVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASF-TLTAAAEEEKVLGETANI 1339
+D + + +P Q +A T + ++SE++ + ++ +E+E V+ T +
Sbjct: 961 ---FVDPNRSPAGPAATP----AQAQAASTPRKARASESTARSSSSESEDEDVIPATQCL 1013
Query: 1340 -------LETGETLEP--------AGAHLVLEEK--SSEKNEDFAAHPGEDAVPTGPDCQ 1382
+ T T P AGA E S K ++ A + AV T P
Sbjct: 1014 TPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATS 1073
Query: 1383 AKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQ---------------------- 1420
+ST V T K E ++ T SD+ ++
Sbjct: 1074 PQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT 1133
Query: 1421 -VACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQ 1479
V + +E+ E+ ++ S L+ + + AT L S
Sbjct: 1134 LVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPS 1193
Query: 1480 TQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQA----------- 1528
+ + D D QE +PQ +A +P T KE + T ++
Sbjct: 1194 VSSTLAAKDDPDGKQEA-----KPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQ 1248
Query: 1529 ------HSDISKDMSEASEKTMTVEVEGSTVN------DQQLEEVVLPSEEEG--GGAGT 1574
S+I++ + +V+ S V +Q+ ++VV ++E G
Sbjct: 1249 ASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESR 1308
Query: 1575 KSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNS---ALADTDASGGLTKESPD 1631
K D A R +K + E G+ PE ++ A D + G KE
Sbjct: 1309 KRKLSGDQPAARTPRSKKK-KKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKG 1367
Query: 1632 TNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTE 1683
+ +D E ELQ+G E P++++E +K ++ E E
Sbjct: 1368 KGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKE 1419
Score = 61.2 bits (147), Expect = 8e-09
Identities = 219/1059 (20%), Positives = 362/1059 (34%), Gaps = 213/1059 (20%)
Query: 54 SESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAG 113
S+S+ E L +Q +G K + + T+ + + K G G
Sbjct: 482 SDSDREALAAMNAAQVKPLG--------------KSPQVKPASTMGMGPLGKGAGPVPPG 527
Query: 114 AGDHKDPSLGAG------EAASKESEPKQSTEKPEETLKREQ------------SHAEIS 155
PS G E++S+ES E P ++ S
Sbjct: 528 KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG 587
Query: 156 PPAESGQAVEECKEE---GEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKK 212
PP ++G + K E + +E S SA+S +P Q +
Sbjct: 588 PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAA--------QAKPALKIP 639
Query: 213 TSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRL 272
+ PK+ AS K P +V T+ KA A+ +S PA + R
Sbjct: 640 QTKACPKKTNTTASAKVA---PVRVGTQAPRKAGTATSPAGSS-------PAVAGGTQR- 688
Query: 273 SAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK-----IEVHQEEV-----VAEVH 322
P+E+ S + SEE+ LA V K ++V V + +
Sbjct: 689 ---------PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT 739
Query: 323 VSTVEERTEEQKTEV--EETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQ 380
+ +T T+V E+ S +EE E D+E A PA+ +K+T
Sbjct: 740 APVLPGKTGPTVTQVKAEKQEDSESSEE--ESDSEEAAASPAQVKTSVKKTQAKANP--- 794
Query: 381 GADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRG 440
A +P K P VV+ + KV+ P++ ST L RG
Sbjct: 795 AAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVK-PPVRNPQNSTVLA----------RG 843
Query: 441 GGDEES-GEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEE--- 496
S G+ A + EE G S S E E T LA+V+ G+ +
Sbjct: 844 PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAET-----LAQVKPSGKTHQIRA 898
Query: 497 GATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQ 556
E R+G P P K +++ K+D+ SS ES +
Sbjct: 899 ALAPAKESPRKGAAP-------TPPGKTGPSAAQAGKQDDSGS------SSEESDSDGEA 945
Query: 557 EEMKGSVEEPKPE----EPKRKVDTSVSWEALICVGSSKKRAR------RGSSSDEEGG- 605
S + KP +P R + A S+ ++AR R SSS+ E
Sbjct: 946 PAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDED 1005
Query: 606 -------------------PKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSS- 645
P A KA AG + I G ++ P S
Sbjct: 1006 VIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSA 1065
Query: 646 ----PEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPG 701
P + T + T ++ P + +K E S+DS S + S+ E G
Sbjct: 1066 VGTLPATSPQSTSVQAKGT-NKLRKPKLPEVQQATKAPESSDDSEDSS--DSSSGSEEDG 1122
Query: 702 KEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEY--DAVER 759
+ + G R + E+ E ++EDD P+ LS Y +
Sbjct: 1123 EGPQGAKSAHTLVGPTPSRTETLVEETAAE------SSEDDVVAPSQSLLSGYMTPGLTP 1176
Query: 760 EKMEAQQAQKSAEQPEQKAATEVSK-------ELSESQVHMMAAAVADGTRAA---TIIE 809
+A +A + ++T +K E Q M + G AA T +
Sbjct: 1177 ANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQK 1236
Query: 810 ERSPSW-----------ISASVTEPL---------EQVEAEAALLTEEVLEREVIAEEEP 849
R P + +++T+ L QV+A + E+LE+E ++
Sbjct: 1237 SRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQE--RKKVV 1294
Query: 850 PTVTEPLPENREARGDTVVSE--AELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSA 907
T E + E+R + + A TP + + LGA EG EAS + E T
Sbjct: 1295 DTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKK----LGAGEGGEASVSPEKT----- 1345
Query: 908 VSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQL-PGTGGPED 966
TT + ++ G D++E++ + Q ++ +EE Q GT D
Sbjct: 1346 --------STTSKGKAKRDKASG--DVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGD 1395
Query: 967 VLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKT 1005
P + E ++ +++ + K++ K +++++
Sbjct: 1396 QSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSES 1434
Score = 57.8 bits (138), Expect = 9e-08
Identities = 101/452 (22%), Positives = 163/452 (36%), Gaps = 65/452 (14%)
Query: 150 SHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGW 209
+H I+P A A +E K E P + V S G T Q +
Sbjct: 1027 AHPRIAPKASMAGA-----SSSKESSRISDGKKQEGPATQVDSAVG-TLPATSPQSTSVQ 1080
Query: 210 RKKTS-FRKPKEDEVEASEKKKEQEPEKVDT-------EEDGKAEVASEKLTASEQAHPQ 261
K T+ RKPK EV+ + K E + D+ EEDG+ ++ P
Sbjct: 1081 AKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPS 1140
Query: 262 EPAESAHEPRLSAEYEKVELPSEEQVSGSQGPS---EEKPAPLATEVFDEKIEVHQEEVV 318
E + + V PS+ +SG P A AT D V
Sbjct: 1141 RTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAA 1200
Query: 319 AEVHVSTVEERTEE------QKTEVEETA-GSVPAEELVEMDAEPQEAEPAKELVKLKET 371
+ E + ++ KT +E A G+ P + L
Sbjct: 1201 KDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQ 1260
Query: 372 CVSGED-PTQGADLSPD-EKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKK 429
C+ G+ P A + KVL++ E +V + + K S +KL +
Sbjct: 1261 CLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAAR 1320
Query: 430 LSGKKQKGKRGGGDEESGEHTQVPADSPDSQ-------------EEQKGESSASS---PE 473
K+K K G G E GE + P + + +E+KG+ S S +
Sbjct: 1321 TPRSKKKKKLGAG--EGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKD 1378
Query: 474 EPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDK 533
EPEE L+KG+ G E G S+ + K+E KK +R + +K
Sbjct: 1379 EPEEE--LQKGM------GTVEGGDQSNPKSKKE-------------KKKSDKRKKDKEK 1417
Query: 534 EDELDKVKSATLSSTESTASEMQEEMKGSVEE 565
+++ K K A+ +ES + + +++ K + E+
Sbjct: 1418 KEKKKKAKKASTKDSESPSQKKKKKKKKTAEQ 1449
Score = 35.4 bits (80), Expect = 0.47
Identities = 29/140 (20%), Positives = 57/140 (40%), Gaps = 17/140 (12%)
Query: 118 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEE-CKEEGEEKQE 176
K LGAGE P++++ + KR+++ ++ G + K+E EE+ +
Sbjct: 1326 KKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ 1385
Query: 177 KEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEK 236
K S S+ ++K K K+D+ + +KKK ++
Sbjct: 1386 KGMGTVEGGDQSNPKSK----------------KEKKKSDKRKKDKEKKEKKKKAKKAST 1429
Query: 237 VDTEEDGKAEVASEKLTASE 256
D+E + + +K TA +
Sbjct: 1430 KDSESPSQKKKKKKKKTAEQ 1449
>gi|238624188 diffuse panbronchiolitis critical region 1 protein [Homo
sapiens]
Length = 1393
Score = 82.4 bits (202), Expect = 3e-15
Identities = 262/1342 (19%), Positives = 451/1342 (33%), Gaps = 209/1342 (15%)
Query: 116 DHKDPSLGAGEAASKESEP----KQSTEKPEETLKREQSHAE--ISPPAESGQAVEEC-- 167
+H+ P ++++ +P ++S + + T ++S + I+P +S +
Sbjct: 114 NHEAPPTSEENSSNQGKDPMIRNQRSVDPADSTTTHKESAGKKHITPAPKSKINCRKSTT 173
Query: 168 -KEEGEEKQEK--EPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVE 224
K K +K P + + S ++ + T F G + ++K++ K
Sbjct: 174 GKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHKTTTSFHNSGNSQTKQKSTSFPEKITAAS 233
Query: 225 ASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSE 284
+ K PE+ + ED + VAS+KL + QE +SA L
Sbjct: 234 KTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTKNIQE--------TISANELTQSLAEP 285
Query: 285 EQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSV 344
+ G P+P E E + +S E ++T E TA
Sbjct: 286 TEHGGRTANENNTPSPA------EPTENRERTANENTTLSPAEPIENRERTANENTA--- 336
Query: 345 PAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEM 404
A P E +E+ + T + +PT+ + + +E P E E
Sbjct: 337 ------PFPAGPTE---NREMTANENTTLFPAEPTEHGERTANENTTPSPAE-PTEHGER 386
Query: 405 LSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQV--------PADS 456
+++ P T G + + E GE T + PA+
Sbjct: 387 TANENTTPSPAEP-----TEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEP 441
Query: 457 PDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFK 516
+++E E++ SP P E ++ A E T + E A+ K
Sbjct: 442 TENRERTANENTTPSPAGPTE-----------NRETTANEKTTLSPVEPTENRETTANEK 490
Query: 517 KMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVD 576
+P + P+E+ + K+ T SS E T + + P P EP +
Sbjct: 491 TTPSPAE----PTENGQRTPFANEKT-TSSSAEPTEHGERTPLANENTTPSPAEPTENRE 545
Query: 577 TSVSWEALICVGSSKKRARRGSSSDEEGGPK-AMGGDHQKADEAGKDKETGTDGILAGSQ 635
+ + + + R ++E+ P A ++ + +K T + +
Sbjct: 546 RTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQRTPFANEKTTSSSAEPTEHE 605
Query: 636 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 695
E P ++ PTE + E+ TP ++ E + + T
Sbjct: 606 ERTPLANENTTPSPAEPTENRERTANEN----TTPSPAGPTENREMTANEKTTLFPAEPT 661
Query: 696 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 755
+ E E S P +R E+ A PT E LS +
Sbjct: 662 ENRERTANEKTTS-SPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLANENTTLSPAE 720
Query: 756 AVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSW 815
E + A +K+ P + + +E+ A +G R E+ +P
Sbjct: 721 PTENRERTAN--EKTTPFPAEPTENR-ERTANENTTPSPAQPTENGDRTPLANEKTTP-- 775
Query: 816 ISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTP 875
S+ EP E + T E+ + EP AE TP
Sbjct: 776 ---SLAEPTENGKR-----TPFANEKTTSSSAEP------------------TEHAERTP 809
Query: 876 EAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIE 935
A T+ P E E +A E+TT+ + ++ +S E+ TP P
Sbjct: 810 LA-NENTTSSPAEPTENRERTANEKTTQFPAEPTENRES-TANEKTTPFP----AEPTEN 863
Query: 936 EQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVV 995
+ + + AE + E P + L P + P E E +
Sbjct: 864 REWTANENTTLSPAEPTEHEEMTP-LANEKTTLSPAE------PTENGERT--------- 907
Query: 996 LKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMV 1055
PFT K TTP S E + ++E+ T +AE + +
Sbjct: 908 -----------PFTNEK----TTPSSAEPTEHGERTPLANEITTPSRAEPTE--HGERIA 950
Query: 1056 MEQAIPPDSVETPTDSETDGSTPVADFDAPGT---TQKDEIVEIHEENEVASGTQSGGTE 1112
E+A P +P G T V + P + T+ E + EN S T+S TE
Sbjct: 951 NEKATP-----SPAKPTEHGETTVNEDTTPSSAEPTENGERTPLANENTTTSPTES--TE 1003
Query: 1113 AEAVPAQKERPPAPSSFVFQEETKEQSKMEDTL-------EHTDKEVSVETVSILSKTEG 1165
A ++ P+P+ E + S E T+ EH + S + S +
Sbjct: 1004 HGERTANEKTTPSPAEPTEHGE-RTPSANEKTIPSPAKPTEHEEMTPSANENTTPSPVKP 1062
Query: 1166 TQEADQ--YADEKTKDVPFFEGLEGSIDTG--ITVSREKVTEVALK----GEGTEEAECK 1217
T+ ++ A+EK P EG + G T + EK+T K GE T K
Sbjct: 1063 TEHGEKTTLANEKITLSP-----EGPTEHGAKTTSANEKITPSLAKPTEHGERTTSPNDK 1117
Query: 1218 -----------KDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAV 1266
+D A +P P++ + EK T V E+ EH
Sbjct: 1118 ITSSAAESTEHRDRATSANVITPAPAEPIKHAKRTTLAHEKM----TQVTEKSTEHPEKT 1173
Query: 1267 TVSEEVSKQLLQTVNVPIIDGAKEVSSL-EGSPPPCLGQEEAVCTKIQVQSSEASFTLTA 1325
T + E + +T P + K + + + +P P E T + ++ +A T
Sbjct: 1174 TSTTE---KTTRTPEKPTLYSEKTICTKGKNTPVPEKPTENLGNTTLTTETIKAPVKSTE 1230
Query: 1326 AAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKS 1385
E +TA + +T + L SS N+ H VPTG S
Sbjct: 1231 NPE------KTAAVTKTIKPSVKVTGDKSLTTTSSHLNKTEVTH----QVPTG------S 1274
Query: 1386 TPVIVSATTKKGLSSDLEGEKT 1407
+I S T ++S+ G ++
Sbjct: 1275 FTLITSRTKLSSITSEATGNES 1296
Score = 65.1 bits (157), Expect = 6e-10
Identities = 181/883 (20%), Positives = 299/883 (33%), Gaps = 118/883 (13%)
Query: 842 EVIAEEEPPTVTEPLPENREARGD---TVVSEAELTPEAVTAAETAGPLGAEEGTEASAA 898
++ A + T PE E D TV S+ LT ET + A E T++ A
Sbjct: 228 KITAASKTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTKNIQET---ISANELTQSLA- 283
Query: 899 EETTEMVSAVSQLTDSPD----------TTEEATPVQEVEGGVPDIEEQERRTQEVLQAV 948
E TE + ++P T E T + E IE +ER E
Sbjct: 284 -EPTEHGGRTANENNTPSPAEPTENRERTANENTTLSPAE----PIENRERTANENTAPF 338
Query: 949 AEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPF 1008
E ++ T L P + P E E + + T + EP
Sbjct: 339 PAGPTENREM--TANENTTLFPAE------PTEHGERTANENTTP---------SPAEPT 381
Query: 1009 TQGKVVGQ--TTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVE 1066
G+ TTP E + +++ T+ AE+ + + E P +
Sbjct: 382 EHGERTANENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEP 441
Query: 1067 TP----TDSETDGSTPVADFDAPGTTQKDEI----VEIHEENEVASGTQSGGTEAEAVPA 1118
T T +E +P + TT ++ VE E E + ++ + AE
Sbjct: 442 TENRERTANENTTPSPAGPTENRETTANEKTTLSPVEPTENRETTANEKTTPSPAEPTEN 501
Query: 1119 QKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTK 1178
+ P F E S E T EH ++ + S E T+ ++ A+EKT
Sbjct: 502 GQRTP-------FANEKTTSSSAEPT-EHGERTPLANENTTPSPAEPTENRERTANEKTT 553
Query: 1179 DVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVERE 1238
P E E T + + EK T E TE + + S + P ER
Sbjct: 554 PSPA-EPTENGDRTPL--ANEKTTPSL--AEPTENGQRTPFANEKTTSSSAEPTEHEERT 608
Query: 1239 MVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSP 1298
+ + AEPT E T + + + + + A+ + E +
Sbjct: 609 PLANENTTPSPAEPTENRERTANENTTPSPAGPTENREMTANEKTTLFPAEPTENRERTA 668
Query: 1299 PPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEK 1358
A T+ ++ A+ T+++ E GE + TL PA E
Sbjct: 669 NEKTTSSPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLANENTTLSPAEPTENRERT 728
Query: 1359 SSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTT-SLKWKSDEV 1417
++EK F A P E+ T + +T + T+ G + L EKTT SL ++
Sbjct: 729 ANEKTTPFPAEPTENRERTANE----NTTPSPAQPTENGDRTPLANEKTTPSLAEPTENG 784
Query: 1418 DEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSE 1477
E S + E E ++ +N + + E TA E T
Sbjct: 785 KRTPFANEKTTSSSAEPTEHAE-------RTPLANENTTSSPAEPTENRERTANEKTT-- 835
Query: 1478 LQTQAHVIKADSQDAGQETEKEGEEP----QASAQDETPITSAK--EESESTAVGQAHSD 1531
Q A + A ++T EP + +A + T ++ A+ E E T + +
Sbjct: 836 -QFPAEPTENRESTANEKTTPFPAEPTENREWTANENTTLSPAEPTEHEEMTPLANEKTT 894
Query: 1532 IS-KDMSEASEKTMTVEVEGSTVNDQQLE---------EVVLPSEEEGGGAGTKSVPEDD 1581
+S + +E E+T + + + + E E+ PS E P +
Sbjct: 895 LSPAEPTENGERTPFTNEKTTPSSAEPTEHGERTPLANEITTPSRAE---------PTEH 945
Query: 1582 GHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKE 1641
G + E+ S +P E + + DT S P NG +
Sbjct: 946 GERIANEKATPSPAKPTE----------HGETTVNEDTTPSSA----EPTENGERTPLAN 991
Query: 1642 DAQEVELQEGKVHSE--SDKAITPQAQEELQKQERESAKSELT 1682
+ E H E +++ TP E + ER + +E T
Sbjct: 992 ENTTTSPTESTEHGERTANEKTTPSPAEPTEHGERTPSANEKT 1034
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 82.0 bits (201), Expect = 4e-15
Identities = 349/1765 (19%), Positives = 614/1765 (34%), Gaps = 351/1765 (19%)
Query: 91 KTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGE---------AASKESEPKQSTEKP 141
+TEK V +K +G D P AG+ + E +P S
Sbjct: 1921 RTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSPTSK 1980
Query: 142 EETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKF 201
E ++ S E+ +SGQ + K E + + + E V E G +
Sbjct: 1981 TERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQR 2040
Query: 202 FTQGWAGWRKKTSFRKPKEDEVEASEKKKEQE-PEKVDTEEDGKAEVASEKLTASEQAHP 260
Q K R P E+ + K + GK +V S K+ Q+ P
Sbjct: 2041 EAQKTENQTIKRGQRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVP 2100
Query: 261 QEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAE 320
+E E +E K ++ E+ Q + K + +EV +++E + +
Sbjct: 2101 EE------ESHRESEVPKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDK----- 2149
Query: 321 VHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQ 380
+ E TE+ + +++ S P +D E PA + L+ + G
Sbjct: 2150 YQQFRLSEETEKAQLHLDQVLTS-PFNTTFPLDYMKDEFLPA---LSLQSGALDGS---- 2201
Query: 381 GADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQG--------------SPLKKLFTSTG 426
++ +E V P ++ +SS+E K +G SP KK TG
Sbjct: 2202 -SESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSP-KKSEEQTG 2259
Query: 427 LKKLSGKKQ--------------KGKRGGGDEESGEHTQVPADSPDS--QEEQKGESSAS 470
K S K + K GG +E T+ S +S +E G +
Sbjct: 2260 ETKESTKTETTTEIRSEKEHPTTKDITGGSEERGATVTEDSETSTESFQKEATLGSPKDT 2319
Query: 471 SPEEPEEIT-CLEKGLAEVQQDGEAEEGATSDGEKK--------------REGVTPWASF 515
SP+ ++ T LA+ G EE A +G++ +E
Sbjct: 2320 SPKRQDDCTGSCSVALAKETPTGLTEEAACDEGQRTFGSSAHKTQTDSEVQESTATSDET 2379
Query: 516 KKMVTPKKRVRRPS--ESDKEDELDKVKSATLS----STESTASEMQEEMKGSVEEPKPE 569
K + P+ V+ + ES + + + L+ +E ++ + + S ++
Sbjct: 2380 KALPLPEASVKTDTGTESKPQGVIRSPQGLELALPSRDSEVLSAVADDSLAVSHKDSLEA 2439
Query: 570 EPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGG---DHQKADEAGKDKETG 626
P + ++S + K+ R S PK G H A E
Sbjct: 2440 SPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKTELL 2499
Query: 627 TDGILA---------GSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSK 677
T+ GS E D + +S E +G + E VTP+ S
Sbjct: 2500 TEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDVST 2559
Query: 678 -----LEEKSEDSIAGSGVEHS-TPDTEPGKEESWVSIKKFIPGRRKKRPDGKQE----- 726
+ E +E+ + +G + TP+ E K + + + + K++ D K+E
Sbjct: 2560 PKPAVIHECAEEDDSENGEKKRFTPEEEMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEE 2619
Query: 727 -----------QAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPE 775
V++ TG+ ED+S VP +V E+++ S+E
Sbjct: 2620 SSSSSDPDADCSVDVDEPKHTGSGEDESGVPVLVT-----------SESRKVSSSSE--- 2665
Query: 776 QKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASV--TEPLEQVEAEAAL 833
SE ++ + G +I + PS + +S+ E+V+ + +
Sbjct: 2666 -----------SEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMDSNSSPEEVQFQPVV 2714
Query: 834 LTEEVLEREVIAEEEPPTVTEP------LPENREARGDTVVSEAELTPEAVTAAETAGPL 887
+ + +EEP E L E+R A V +EAE +T P
Sbjct: 2715 SKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHA----VSTEAEDRSYDKLNRDTDQPK 2770
Query: 888 GAE-EGTEASAAEETTEMVSAVSQLTDSPDTTEE-----------ATPVQEVEGGVPDIE 935
+ G EA + + VS+ Q D E+ T ++ EG D+
Sbjct: 2771 ICDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEKDTEGEELDVS 2830
Query: 936 EQERRTQEVLQAVAEKVKEESQLP------GTGGPEDV--LQPVQRAEAERPEEQAEA-- 985
E + +E S LP G ED+ +Q+ E + +E E
Sbjct: 2831 RAESPQAD---CPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTDETFENLP 2887
Query: 986 -------SGLKKETD-----VVLKVDAQEAK------TEPFTQGKVVGQTTPESFEKAPQ 1027
S + +TD V + A+ + T P+ V Q+ S E Q
Sbjct: 2888 KDCPSQDSSITTQTDRFSMDVPVSDLAENDEIYDPQITSPYEN--VPSQSFFSSEESKTQ 2945
Query: 1028 V----TESIESSEL-------------VTTCQAETLAGVKS----QEMVMEQA------- 1059
T S SSE+ V + + T+ +S Q++ ME
Sbjct: 2946 TDANHTTSFHSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQESTLWE 3005
Query: 1060 IPPDSVETPTDSETDGSTPVA------------DFDAPGTTQ---KDEIVE--IHEENEV 1102
+ DSV + + +T V D D+ ++ DE E + EE +
Sbjct: 3006 MQSDSVSSSFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQK 3065
Query: 1103 ASGT----QSGGTEAEAVPAQ---KERPPAPSS--FVFQEETKEQSKMEDTLEHTDKEVS 1153
G QS GT + PA+ +E P F+FQE + ++ T + +
Sbjct: 3066 IFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYA 3125
Query: 1154 VETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEE 1213
E+ + ++E D K EG G+ + S E + K +E
Sbjct: 3126 DESFHFFQIGQESREETLSEDVK-------EGATGADPLPLETSAESLALSESKETVDDE 3178
Query: 1214 AECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVS 1273
A+ DD E + + + +M + E E V + L
Sbjct: 3179 ADLLPDDVSEEVEEIPASDAQLNSQMGISASTETPTKEAVSVGTKDLP------------ 3226
Query: 1274 KQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVL 1333
+QT ++P + G K++S + S P Q + V S + ++ EE+K +
Sbjct: 3227 --TVQTGDIPPLSGVKQISCPDSSEPAVQVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSV 3284
Query: 1334 GETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSAT 1393
E + +N F + V T P STP SA
Sbjct: 3285 IEIPT--------------------APMENVPFTESKSKIPVRTMP----TSTPAPPSAE 3320
Query: 1394 TKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLV- 1452
+ +S D S + ++ DE ++ V V ++ +E + + +L+T K V
Sbjct: 3321 YESSVSEDF-----LSSVDEENKADEAKPKSKLPVKVPLQRVEQQ--LSDLDTSVQKTVA 3373
Query: 1453 ---QNIIQTAVDQFVRTEETATEM---LTSELQTQAHV-IKADSQDAGQETEKEGEE--- 1502
Q++ A D ++E A+ + ++T+++ + +S++ +E E E EE
Sbjct: 3374 PQGQDMASIAPDNRSKSESDASSLDSKTKCPVKTRSYTETETESRERAEELELESEEGAT 3433
Query: 1503 ------PQASAQDETPITSAKEESESTAVGQAH------------SDISKDMSEASEKTM 1544
+ + + +S + + T + H +IS + S+ ++
Sbjct: 3434 RPKILTSRLPVKSRSTTSSCRGGTSPTKESKEHFFDLYRNSIEFFEEISDEASKLVDRLT 3493
Query: 1545 TVEVEGSTVNDQQ----LEEVVL----PSEEEGGGAGTKSVPED--DGHALLAERIEKSL 1594
E E V+D + LE V+ P E E SVPED D + E IE +L
Sbjct: 3494 QSEREQEIVSDDESSSALEVSVIENLPPVETE------HSVPEDIFDTRPIWDESIE-TL 3546
Query: 1595 VEPKEDEKG-DDVDDPENQNSALAD 1618
+E DE G D +DP+++ + +
Sbjct: 3547 IERIPDENGHDHAEDPQDEQERIEE 3571
Score = 78.2 bits (191), Expect = 6e-14
Identities = 323/1614 (20%), Positives = 538/1614 (33%), Gaps = 256/1614 (15%)
Query: 120 PSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISP--------------------PAE 159
PSL + A PK + + + H +SP PA
Sbjct: 1811 PSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPAS 1870
Query: 160 SGQAVEECK--EEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKK---TS 214
S E+ + + P S ++ P S +G T K+ K +
Sbjct: 1871 SSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSP 1930
Query: 215 FRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVA-SEKLTASEQAHPQEPAESAHEPRLS 273
R K V S + + +P + + V+ S K P E E
Sbjct: 1931 GRTEKRLPVSPSGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSPTSKTERIEETMSV 1990
Query: 274 AEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEE--VVAEVHVSTVEERT- 330
E K ++ G E K A K+ V +E+ ++ + E +T
Sbjct: 1991 RELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQREAQKTENQTI 2050
Query: 331 -EEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELV---------------------KL 368
Q+ V TA S + + + ++A KE V ++
Sbjct: 2051 KRGQRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVPEEESHRESEV 2110
Query: 369 KETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVE-------MLSSQERMKVQ------- 414
+ ++ E +SPD K + E + E+E S+E K Q
Sbjct: 2111 PKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDKYQQFRLSEETEKAQLHLDQVL 2170
Query: 415 GSPLKKLFTSTGLKK--LSGKKQKGKRGGGDEESGEHTQVPADSP-----------DSQE 461
SP F +K L + G ES ++ V A SP S+E
Sbjct: 2171 TSPFNTTFPLDYMKDEFLPALSLQSGALDGSSESLKNEGV-AGSPCGSLMEGTPQISSEE 2229
Query: 462 EQKGESSASSPE-EPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVT 520
K E A +PE PE ++ K E Q GE +E K E T S K+ T
Sbjct: 2230 SYKHEGLAETPETSPESLSFSPKKSEE--QTGETKEST------KTETTTEIRSEKEHPT 2281
Query: 521 PKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVS 580
K + SE ++ + T S ST S +E GS PK PKR+ D + S
Sbjct: 2282 TKD-ITGGSE-------ERGATVTEDSETSTESFQKEATLGS---PKDTSPKRQDDCTGS 2330
Query: 581 WEALICVGSSKKRARRGSSSDE--EGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHD 638
C + K G + + + G + G K D E + +
Sbjct: 2331 -----CSVALAKETPTGLTEEAACDEGQRTFGSSAHKTQ---TDSEVQESTATSDETKAL 2382
Query: 639 PGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDT 698
P +S G+ ++ +GV L P + S+ L ++DS+A S +
Sbjct: 2383 PLPEASVKTDTGTESKPQGVIRSPQGLELALPSRDSE-VLSAVADDSLAVSHKDSLEASP 2441
Query: 699 EPGKEESWVSIKKFIPGRRKKRP-DGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAV 757
S + P K+ P E +PVE G +PA V +E
Sbjct: 2442 VLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKTE---- 2497
Query: 758 EREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWIS 817
TEV+ S +A D +++E S +S
Sbjct: 2498 --------------------LLTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLS 2537
Query: 818 ASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPE- 876
T E+V E T +V + +P + E E+ G+ + TPE
Sbjct: 2538 PD-TPSSEEVSYEVTPKTTDV------STPKPAVIHECAEEDDSENGE----KKRFTPEE 2586
Query: 877 ----AVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQ----EVE 928
VT + L E + +E + S+ S D+ + + P E E
Sbjct: 2587 EMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSGEDE 2646
Query: 929 GGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGL 988
GVP + E R + + +E E +QL + +PV R + P + S
Sbjct: 2647 SGVPVLVTSESRK---VSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMDSNS 2703
Query: 989 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAG 1048
E ++ +K F + + +S E+ + E V+T +AE +
Sbjct: 2704 SPEE---VQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVST-EAEDRSY 2759
Query: 1049 VKSQEMVMEQAIPPDSVETPTDSETDGSTPVAD-FDAPGTTQKDEIVEIHEENEVASGTQ 1107
K + I D S + + PV+ +P DE I++E+ GT
Sbjct: 2760 DKLNRDTDQPKI-CDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTH 2818
Query: 1108 SGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEV--SVETVSILSKTEG 1165
TE E + R +P + E S + L KE+ + S + KTE
Sbjct: 2819 EKDTEGEELDV--SRAESPQADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEV 2876
Query: 1166 TQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQ 1225
T + D+ + KD P S D+ IT ++ + + E E
Sbjct: 2877 T-KTDETFENLPKDCP-------SQDSSITTQTDRFSMDVPVSDLAENDEI-------YD 2921
Query: 1226 SHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPII 1285
SP V + E KT+ + H +VT++ V ++ + + +
Sbjct: 2922 PQITSPYENVPSQSFFSSEESKTQTDANHTTSFHSSEVYSVTITSPVEDVVVASSSSGTV 2981
Query: 1286 DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGET 1345
+ S+ EG Q+E+ ++Q S +SF T +A V + + ++ T
Sbjct: 2982 --LSKESNFEGQDIKMESQQESTLWEMQSDSVSSSFEPTMSATTTVVGEQISKVIITKTD 3039
Query: 1346 LEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGE 1405
++ + E+ +E F A E+ GL D + +
Sbjct: 3040 VDSDSWSEIRED-----DEAFEARVKEEEQKI------------------FGLMVDRQSQ 3076
Query: 1406 KTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVR 1465
TT D P E T +S+ + Q F
Sbjct: 3077 GTT------------------------PDTTPARTPTEEGTPTSEQNPFLFQEG-KLFEM 3111
Query: 1466 TEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKE-----ES 1520
T A +M ++ Q++ +ET E + A+ D P+ ++ E ES
Sbjct: 3112 TRSGAIDMTKRSYADESFHFFQIGQESREETLSEDVKEGATGADPLPLETSAESLALSES 3171
Query: 1521 ESTAVGQAH---SDISKDMSE--ASEKTMTVEVEGSTVNDQQLEEVV------LPSEEEG 1569
+ T +A D+S+++ E AS+ + ++ S + +E V LP+ + G
Sbjct: 3172 KETVDDEADLLPDDVSEEVEEIPASDAQLNSQMGISASTETPTKEAVSVGTKDLPTVQTG 3231
Query: 1570 -----GGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDD--PENQNSAL 1616
G S P+ A+ + +L ++GDD D PE Q S +
Sbjct: 3232 DIPPLSGVKQISCPDSSEPAVQVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSVI 3285
Score = 68.9 bits (167), Expect = 4e-11
Identities = 306/1527 (20%), Positives = 528/1527 (34%), Gaps = 297/1527 (19%)
Query: 168 KEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASE 227
+ E +++QE+E ++E ++ET S K + + E SE
Sbjct: 1458 ESESDQEQEEEIDMTSEKNDETESTET-SVLKSHLVN-------EVPVLASPDLLSEVSE 1509
Query: 228 KKKE--QEPEKVDTEEDGKA-EVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSE 284
K++ + + T+ KA + ++L + + P EP E R+ + EKV +E
Sbjct: 1510 MKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVE--RVKEDLEKV---NE 1564
Query: 285 EQVSGSQGPSEEKPAPLATE----------VFDEKIEVHQEEVVAEV-HVSTVEERTEEQ 333
SG+ E +E V DE+IE +++ E+ VE R +++
Sbjct: 1565 ILRSGTCTRDESSVQSSRSERGLVEEEWVIVSDEEIEEARQKAPLEITEYPCVEVRIDKE 1624
Query: 334 -KTEVEETAGSV------PAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSP 386
K +VE+ + + V + E + K K + V +G D+ P
Sbjct: 1625 IKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAVGRSSEKEGKDIPP 1684
Query: 387 DEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEES 446
DE S+Q++ K S G+KK +K K K+ +E
Sbjct: 1685 DETQ---------------STQKQHK----------PSLGIKKPVRRKLKEKQKQKEEGL 1719
Query: 447 GEHTQVPADSPDSQEEQKGESSASSPEEPEEITCL-----EKGLAEVQQDGEAEEGATSD 501
+ S EE GE +PE + E + ++ +A + D
Sbjct: 1720 QASAEKAELKKGSSEESLGEDPGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVED 1779
Query: 502 GEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKG 561
+K R + K+ V PKK RP + +K
Sbjct: 1780 EQKGRSKLPIRVKGKEDV-PKKTTHRPHPA-----------------------ASPSLKS 1815
Query: 562 SVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGK 621
P PK + +++S SS K R H + K
Sbjct: 1816 ERHAPGSPSPKTERHSTLS--------SSAKTER-----------------HPPVSPSSK 1850
Query: 622 DKETGTDGILAGSQEHDPGQGSSSPEQ---AGSPTEGEGVSTWESFKRLVTPRKKSKSKL 678
++ A ++ H P SS E+ T+ E S S K P K
Sbjct: 1851 TEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKT 1910
Query: 679 EEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAG---- 734
+++ S +G +H P PG+ E K +P R D Q PV AG
Sbjct: 1911 DKRPPVSPSGRTEKH--PPVSPGRTE------KRLPVSPSGRTDKHQ---PVSTAGKTEK 1959
Query: 735 --PTGANEDDSDVPAVVPLSEYDAVE-----REKMEAQQA-------------QKSA--E 772
P + P V P S+ + +E RE M+A Q+ KSA +
Sbjct: 1960 HLPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQK 2019
Query: 773 QPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAA 832
QP++K V KE ++ A T TI + + ++ +V +
Sbjct: 2020 QPQEKGKVRVEKEKGP----ILTQREAQKTENQTIKRGQRLPVTGTAESKRGVRVSSIGV 2075
Query: 833 LLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSE----------AELTPEAVTAAE 882
+ +E + + P + +PE R V E +++P+ T+ +
Sbjct: 2076 KKEDAAGGKEKVLSHKIPEPVQSVPEEESHRESEVPKEKMADEQGDMDLQISPDRKTSTD 2135
Query: 883 TAGPLGAE-----EGTEASAAEETTEMVSAVSQLTDSPDTT--------EEATPVQEVEG 929
+ + E + + +EET + + Q+ SP T +E P ++
Sbjct: 2136 FSEVIKQELEDNDKYQQFRLSEETEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQS 2195
Query: 930 GVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAE--AERPEEQAEASG 987
G D + + + V + + E G P+ + + E AE PE E+
Sbjct: 2196 GALDGSSESLKNEGVAGSPCGSLME-------GTPQISSEESYKHEGLAETPETSPESLS 2248
Query: 988 LKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIE--SSELVTTCQAET 1045
+ K + Q +T+ T+ + TT EK T+ I S E T ++
Sbjct: 2249 FSPK-----KSEEQTGETKESTKTET---TTEIRSEKEHPTTKDITGGSEERGATVTEDS 2300
Query: 1046 LAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASG 1105
+S + P D+ D T GS VA K+ + EE G
Sbjct: 2301 ETSTESFQKEATLGSPKDTSPKRQDDCT-GSCSVA-------LAKETPTGLTEEAACDEG 2352
Query: 1106 TQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEG 1165
++ G+ A E S +ETK E +++ TD + ++ +G
Sbjct: 2353 QRTFGSSAHKTQTDSE---VQESTATSDETKALPLPEASVK-TDTGTESKPQGVIRSPQG 2408
Query: 1166 TQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQ 1225
+ A D E L D + VS + E + E + + K D+LE
Sbjct: 2409 LELALPSRDS--------EVLSAVADDSLAVSHKDSLEASPVLE--DNSSHKTPDSLEPS 2458
Query: 1226 SHAKSP------PSPVEREMVVQVEREKTEAEPTHVNEEKLEHET-AVTVSEEVSKQLLQ 1278
+SP SPVE +M K P+H +T +T V +LL+
Sbjct: 2459 PLKESPCRDSLESSPVEPKM-------KAGIFPSHFPLPAAVAKTELLTEVASVRSRLLR 2511
Query: 1279 TVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEE---KVLGE 1335
DG+ E SLE T + S ++ + + EE +V +
Sbjct: 2512 DP-----DGSAEDDSLEQ-------------TSLMESSGKSPLSPDTPSSEEVSYEVTPK 2553
Query: 1336 TANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTK 1395
T ++ T +PA H EE SE E P E+ + TK
Sbjct: 2554 TTDV----STPKPAVIHECAEEDDSENGEKKRFTPEEE---------------MFKMVTK 2594
Query: 1396 KGLSSDLEGEKTTSLKWKSDEVDEQVACQ---EVKVSVAIEDL------EPENGILELET 1446
+ +LE E +K + E+ + + SV +++ E E+G+ L T
Sbjct: 2595 IKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSGEDESGVPVLVT 2654
Query: 1447 KSSKLVQNIIQTAVDQFVRTEETATEMLTSE--LQTQAHVIKADSQDAGQETEKEGEEPQ 1504
S+ V + ++ + + ++ A L E ++ Q S D+ E+ +P
Sbjct: 2655 SESRKVSSSSESE-PELAQLKKGADSGLLPEPVIRVQPPSPLPSSMDSNSSPEEVQFQPV 2713
Query: 1505 ASAQ---------DETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVND 1555
S Q E P S +E+ + + + +S + + S + + + + D
Sbjct: 2714 VSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYDKLNRDTDQPKICD 2773
Query: 1556 QQLEEVVLPSEEEGG-GAGTKSVPEDD 1581
E + PS +G +S DD
Sbjct: 2774 GHGCEAMSPSSSAAPVSSGLQSPTGDD 2800
Score = 38.5 bits (88), Expect = 0.056
Identities = 251/1268 (19%), Positives = 439/1268 (34%), Gaps = 205/1268 (16%)
Query: 36 ITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKP 95
+ +D QEE P E+ SES+L E ++A D + K+ + + K
Sbjct: 2722 MNEDTQEE-PGKSEEEKDSESHLAEDRHAVSTEAEDRSYDKLNR------DTDQPKICDG 2774
Query: 96 DTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQST-EKPEETLKREQSHAEI 154
+ ++ ++G + KES Q T EK E + + S AE
Sbjct: 2775 HGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEKDTEGEELDVSRAE- 2833
Query: 155 SPPAE-------SGQAVEEC-KEEGEEKQEKEPSKSAESPTSPV-TSETGSTFKKFFTQG 205
SP A+ S ++ C EG+E E + S+ T T ET K
Sbjct: 2834 SPQADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTDETFENLPKDCPSQ 2893
Query: 206 WAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAE 265
+ +T + +E + +P+ E+ V S+ +SE++ Q A
Sbjct: 2894 DSSITTQTDRFSMDVPVSDLAENDEIYDPQITSPYEN----VPSQSFFSSEESKTQTDAN 2949
Query: 266 SAHEPRLSAEYE-KVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVS 324
S Y + P E+ V S E D K+E QE + E+
Sbjct: 2950 HTTSFHSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQESTLWEMQSD 3009
Query: 325 TVEERTE-----------EQKTEVEETAGSVPAEELVEM--DAEPQEAEPAKELVKLKET 371
+V E EQ ++V T V ++ E+ D E EA +E K+
Sbjct: 3010 SVSSSFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGL 3069
Query: 372 CVSGEDPTQGADLSP--------------------DEKVLSKPPEGVV------------ 399
V + D +P + K+ G +
Sbjct: 3070 MVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESF 3129
Query: 400 --------SEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGG---DEESGE 448
S E LS + G+ L TS LS K+ D+ S E
Sbjct: 3130 HFFQIGQESREETLSEDVKEGATGADPLPLETSAESLALSESKETVDDEADLLPDDVSEE 3189
Query: 449 HTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQ------DGEAEEGATSDG 502
++PA S Q G S+++ E ++ K L VQ G +
Sbjct: 3190 VEEIPA-SDAQLNSQMGISASTETPTKEAVSVGTKDLPTVQTGDIPPLSGVKQISCPDSS 3248
Query: 503 EKKREGVTPWASFKKMVTPKKRVRRPSESDKEDE-LDKVKSATLSSTESTASEMQEEMKG 561
E + +++ + V + P S +E + + ++ +A + + T S+ + ++
Sbjct: 3249 EPAVQVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSVIEIPTAPMENVPFTESKSKIPVR- 3307
Query: 562 SVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGK 621
++ P P + ++SVS + L SS DEE KADEA K
Sbjct: 3308 TMPTSTPAPPSAEYESSVSEDFL-------------SSVDEE----------NKADEA-K 3343
Query: 622 DKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEK 681
K + E +S ++ +P +G+ +++ + P +SKS+ +
Sbjct: 3344 PKSKLPVKVPLQRVEQQLSDLDTSVQKTVAP-QGQDMAS-------IAPDNRSKSESDAS 3395
Query: 682 SEDSIAGSGVE-HSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANE 740
S DS V+ S +TE E + + RP + PV+ T +
Sbjct: 3396 SLDSKTKCPVKTRSYTETETESRERAEEL-ELESEEGATRPKILTSRLPVKSRSTTSSCR 3454
Query: 741 DDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVAD 800
+ P + + R +E + E+S E S+ + +
Sbjct: 3455 GGTS-PTKESKEHFFDLYRNSIEFFE--------------EISDEASK-----LVDRLTQ 3494
Query: 801 GTRAATII-EERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLP-E 858
R I+ ++ S S + SV E L VE E + + E++ + I +E T+ E +P E
Sbjct: 3495 SEREQEIVSDDESSSALEVSVIENLPPVETEHS-VPEDIFDTRPIWDESIETLIERIPDE 3553
Query: 859 NREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTT 918
N + E E E + A A LG A + T E + + ++P++
Sbjct: 3554 NGHDHAEDPQDEQERIEERL--AYIADHLGFSWTELARELDFTEEQIHQIR--IENPNSL 3609
Query: 919 EE----------------ATPVQEVE-----GGVPDIEEQERRTQEVLQAVAEKVKEESQ 957
++ AT VE + + E T+ + + ++ E Q
Sbjct: 3610 QDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQ 3669
Query: 958 ---LPGTGGPEDVLQPVQRAEAERPEEQAEAS------------------GLKKETDVVL 996
L + G + + + A+ ++ EEQA + G D V
Sbjct: 3670 TITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVP 3729
Query: 997 KVDAQEAKTE--PFTQGKVVGQTTPESFEKAPQVTE-SIESSELVTTCQAETLAGVKSQE 1053
K + + T P T + V Q + P+ + + VTT ET K+
Sbjct: 3730 KTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMI 3789
Query: 1054 MVMEQAIPPDSVETPTDSE---TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGG 1110
+ + P+ V TP + E T +P + +E E EE+ +
Sbjct: 3790 VPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIV 3849
Query: 1111 TEAEAVPAQKERPPAPSSF-------VFQEETKEQSKMEDTLEHT-DKEVSVETVSILSK 1162
A+ P ER ++F ET + + D HT K+V+ + +
Sbjct: 3850 ESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVS 3909
Query: 1163 TEGTQEAD 1170
+EGT++ +
Sbjct: 3910 SEGTEKEE 3917
Score = 37.0 bits (84), Expect = 0.16
Identities = 162/868 (18%), Positives = 290/868 (33%), Gaps = 130/868 (14%)
Query: 870 EAELTPEAVTAAETAG--PLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 927
E E T +V + P+ A + +E +++ + LT + V+E+
Sbjct: 1478 ETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKEL 1537
Query: 928 EGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAER--------- 978
V EE+ E+++ V E +++ +++ +G VQ + +ER
Sbjct: 1538 ---VKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTRDESSVQSSRSERGLVEEEWVI 1594
Query: 979 -PEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKV-------VGQTTPESFEKAPQVTE 1030
+E+ E + K ++ + E + + +GKV V T + P E
Sbjct: 1595 VSDEEIEEARQKAPLEIT-EYPCVEVRIDKEIKGKVEKDSTGLVNYLTDDLNTCVPLPKE 1653
Query: 1031 SIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1090
+++ + + E LA +S E + IPPD T S P P +
Sbjct: 1654 QLQTVQDKAGKKCEALAVGRSSEKEGKD-IPPDE----TQSTQKQHKPSLGIKKPVRRKL 1708
Query: 1091 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDK 1150
E + EE G Q+ +AE E + E +E T
Sbjct: 1709 KEKQKQKEE-----GLQASAEKAELKKGSSEESLGEDPGLAPEPLPTVKATSPLIEETP- 1762
Query: 1151 EVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEG 1210
SI K + Q+ + + +P R K E K +
Sbjct: 1763 -----IGSIKDKVKALQKRVEDEQKGRSKLPI---------------RVKGKEDVPK-KT 1801
Query: 1211 TEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSE 1270
T +L+ + HA PSP KTE P K E + V+ S
Sbjct: 1802 THRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPSA 1861
Query: 1271 EVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEE 1330
+ + + P +K SP TK + + S S T T
Sbjct: 1862 KTER------HSPASSSSKTEKHSPVSPS----------TKTE-RHSPVSSTKTERHPPV 1904
Query: 1331 KVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQA-KSTPVI 1389
G+T + + P+G +EK+ + E +P P + K PV
Sbjct: 1905 SPSGKT----DKRPPVSPSGR--------TEKHPPVSPGRTEKRLPVSPSGRTDKHQPVS 1952
Query: 1390 VSATTKKGL----SSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI--EDLEPENGILE 1443
+ T+K L S E + S K++ ++E ++ +E+ + + + + G+ E
Sbjct: 1953 TAGKTEKHLPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFE 2012
Query: 1444 LETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQT--------------QAHVIKADS 1489
++ K Q + V++ T E +E QT ++ S
Sbjct: 2013 HKSAKQKQPQEKGKVRVEKEKGPILTQREAQKTENQTIKRGQRLPVTGTAESKRGVRVSS 2072
Query: 1490 QDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVE 1549
+E G+E S + P+ S EE S++ K+ + M +++
Sbjct: 2073 IGVKKEDAAGGKEKVLSHKIPEPVQSVPEEES-----HRESEVPKEKMADEQGDMDLQIS 2127
Query: 1550 GSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDE------KG 1603
EV+ E+ + E+ A L +++ L P K
Sbjct: 2128 PDRKTSTDFSEVIKQELEDNDKYQQFRLSEETEKAQL--HLDQVLTSPFNTTFPLDYMKD 2185
Query: 1604 DDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVH--------- 1654
+ + Q+ AL D S K P E ++ +E H
Sbjct: 2186 EFLPALSLQSGAL---DGSSESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPET 2242
Query: 1655 SESDKAITPQAQEELQKQERESAKSELT 1682
S + +P+ EE + +ES K+E T
Sbjct: 2243 SPESLSFSPKKSEEQTGETKESTKTETT 2270
>gi|239740773 PREDICTED: similar to diffuse panbronchiolitis critical
region 1 [Homo sapiens]
Length = 1400
Score = 80.9 bits (198), Expect = 1e-14
Identities = 218/1167 (18%), Positives = 391/1167 (33%), Gaps = 168/1167 (14%)
Query: 116 DHKDPSLGAGEAASKESEP----KQSTEKPEETLKREQSHAE--ISPPAESGQAVEEC-- 167
+H+ P ++++ +P ++S + + T ++S + I+P +S +
Sbjct: 176 NHEAPPTSEENSSNQGKDPMIRNQRSVDPADSTTTHKESAGKKHITPAPKSKINCRKSTT 235
Query: 168 -KEEGEEKQEK--EPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVE 224
K K +K P + + S ++ + T F G + ++K++ K
Sbjct: 236 GKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHKTTTSFHNSGNSQTKQKSTSFPEKITAAS 295
Query: 225 ASEKKKEQEPEKVDTEEDGKAEVASEKL------------------------------TA 254
+ K PE+ + ED + VAS+KL TA
Sbjct: 296 KTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTKNIQETISANELTQSLAEPTEHGGRTA 355
Query: 255 SEQ--AHPQEPAE----SAHEPRLSAEYEKVE----LPSEEQVSGSQGPSE--EKPAPLA 302
+E P EP E +A+E + E E +E GP+E E A
Sbjct: 356 NENNTPSPAEPTENRERTANENTTLSPAEPTENRERTANENTAPFPAGPTENREMTANEN 415
Query: 303 TEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE--------------- 347
T +F + H E E + E TE + E PAE
Sbjct: 416 TTLFPAEPTEHGERTANENTTPSPAEPTEHGERTANENTTPSPAEPTEHGERTPFANDKT 475
Query: 348 --------------ELVEMDAEPQEAEPA--KELVKLKETCVSGEDPTQGADLSPDEKVL 391
L + P AEP +E + T S PT+ + + +EK
Sbjct: 476 TSSSAESTEHGERTPLANENTTPSPAEPTENRERTANENTTPSPAGPTENRETTANEKTT 535
Query: 392 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 451
P V E + K SP + T G + ++ E GE T
Sbjct: 536 LSP----VEPTENRETTANEKTTPSPAEP--TENGQRTPFANEKTTSSSAEPTEHGERTP 589
Query: 452 V--------PADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGE 503
+ PA+ +++E E + SP EP E E AE T +G+
Sbjct: 590 LANENTTPSPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAE--PTENGQ 647
Query: 504 KKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSV 563
+ TP+A+ +K +E + +E + + + + + +E +E
Sbjct: 648 R-----TPFAN-------EKTTSSSAEPTEHEERTPLANENTTPSPAEPTENRERTANEN 695
Query: 564 EEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDK 623
P P P + + + + + + R ++ P + Q+ A +K
Sbjct: 696 TTPSPAGPTENREMTANEKTTLFPAEPTENRERTANEKTTSSPAEPTENGQRTPFA-NEK 754
Query: 624 ETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSE 683
T + E P ++ PTE + E TP ++ E++
Sbjct: 755 TTSSSAEPTEHGERTPLANENTTLSPAGPTENRERTANEK----TTPFPAEPTENRERTA 810
Query: 684 DSIAGSGVEHSTPD----TEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGAN 739
+ E++TP TE G + + ++ +K P + +GK + P + T ++
Sbjct: 811 N-------ENTTPSPAQPTENG-DRTPLANEKTTPSLAEPTENGK--RTPFANEKTTSSS 860
Query: 740 EDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVA 799
+ ++ PL+ + + +++A + + E ++ + A
Sbjct: 861 AEPTEHAERTPLANENTTSSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPFPA 920
Query: 800 DGTRAATIIEERSPSWISASVTEPLEQVEAE--AALLTEEVLE---REVIAEEEPPTVTE 854
+ T E R + + P E E E L+ +E L+ R+ E P +
Sbjct: 921 EPT------ENREWTANENTTLSPAEPTEHEEMTPLMVDENLQAPFRQGSCAERPKDICA 974
Query: 855 PLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDS 914
+ T SE+ E +T++ T T +S A E T +A+ + +
Sbjct: 975 TV-------ASTTGSESSTASEIITSS-TMSVSATASSTASSTASEITMSSAAIPVSSTA 1026
Query: 915 PDTTEEATPVQE-VEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQR 973
+T +T V E V + +E T + V T G ++
Sbjct: 1027 YETIRFSTAVSEPVTASILALESTLAFTTVSNTTTSSTVTSVPTTASTSGSKN----TTA 1082
Query: 974 AEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIE 1033
EA E A ++T V + A++ P T K TT S ++
Sbjct: 1083 CEATMSETTIAAITASEDTTVSTQTSVIAAESVPHTATKTPTDTTTASVSATVPKNNTLS 1142
Query: 1034 SSELVTTCQAETLAGVKSQEMVMEQAIPPDSVET--PTDSETDGSTPVADFDAPGTTQKD 1091
V T T S+ M S T PT T S A + P + D
Sbjct: 1143 ----VITSTPSTAPNTASKTMTTASKTTTTSTITSLPTTVFTTTSKITAGSEIPTASTTD 1198
Query: 1092 EIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKE 1151
A T++ GT E+ P+ PA ++ T + E+T HT
Sbjct: 1199 SAT-------TAISTKASGTTVESAPSTAPPTPAETTTASVPTTTSTTGSENTGHHTVSS 1251
Query: 1152 VSVETVSILSKTEGTQEADQYADEKTK 1178
V + S++ E + + T+
Sbjct: 1252 VPTTVFATASESSTGSETTRASTSATE 1278
Score = 58.5 bits (140), Expect = 5e-08
Identities = 122/584 (20%), Positives = 200/584 (34%), Gaps = 54/584 (9%)
Query: 842 EVIAEEEPPTVTEPLPENREARGD---TVVSEAELTPEAVTAAETAGPLGAEEGTEASAA 898
++ A + T PE E D TV S+ LT ET + A E T++ A
Sbjct: 290 KITAASKTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTKNIQET---ISANELTQSLA- 345
Query: 899 EETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQL 958
E TE + ++P +P + E E + E+ E+
Sbjct: 346 -EPTEHGGRTANENNTP------SPAEPTENRERTANENTTLSPAEPTENRERTANENTA 398
Query: 959 PGTGGPEDVLQPVQRAEAE----RPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVV 1014
P GP + + P E E + + T + EP G+
Sbjct: 399 PFPAGPTENREMTANENTTLFPAEPTEHGERTANENTTP---------SPAEPTEHGERT 449
Query: 1015 GQ--TTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETP---- 1068
TTP E + +++ T+ AE+ + + E P + T
Sbjct: 450 ANENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEPTENRER 509
Query: 1069 TDSETDGSTPVADFDAPGTTQKDEI----VEIHEENEVASGTQSGGTEAEAVPAQKERPP 1124
T +E +P + TT ++ VE E E + ++ + AE + P
Sbjct: 510 TANENTTPSPAGPTENRETTANEKTTLSPVEPTENRETTANEKTTPSPAEPTENGQRTP- 568
Query: 1125 APSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFE 1184
F E S E T EH ++ + S E T+ ++ A+EKT P E
Sbjct: 569 ------FANEKTTSSSAEPT-EHGERTPLANENTTPSPAEPTENRERTANEKTTPSPA-E 620
Query: 1185 GLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVE 1244
E T + + EK T E TE + + S + P ER +
Sbjct: 621 PTENGDRTPL--ANEKTTPSL--AEPTENGQRTPFANEKTTSSSAEPTEHEERTPLANEN 676
Query: 1245 REKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQ 1304
+ AEPT E T + + + + + A+ + E +
Sbjct: 677 TTPSPAEPTENRERTANENTTPSPAGPTENREMTANEKTTLFPAEPTENRERTANEKTTS 736
Query: 1305 EEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNE 1364
A T+ ++ A+ T+++ E GE + TL PAG E ++EK
Sbjct: 737 SPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLANENTTLSPAGPTENRERTANEKTT 796
Query: 1365 DFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTT 1408
F A P E+ T + +T + T+ G + L EKTT
Sbjct: 797 PFPAEPTENRERTANE----NTTPSPAQPTENGDRTPLANEKTT 836
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 79.0 bits (193), Expect = 4e-14
Identities = 336/1704 (19%), Positives = 595/1704 (34%), Gaps = 224/1704 (13%)
Query: 13 DSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDI 72
DS + +R +K+ T+ H E+T ++ ++ + E +E L P+E +N
Sbjct: 327 DSNEKGERKKEKKEKTEKKFDHS---KKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKA 383
Query: 73 ----GFKKVFKFVGFKFTVKKDKT-EKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAG-E 126
G K+ F + D T T L + ++D E + ++ + + E
Sbjct: 384 KTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDE 443
Query: 127 AASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESP 186
+K+++ K T E + HA + P + + +E +Q ++ S + E
Sbjct: 444 EKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQ-SIAKEKE 502
Query: 187 TSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAE 246
+ + R+K ++ ++ E S K K Q VD EE
Sbjct: 503 ERLLRRQIN--------------REKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKS 548
Query: 247 VASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVF 306
+ + E ++ E + LS + +K EE Q E+ L T
Sbjct: 549 LEPKAARIKEVLKERKVLEK--KVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEH 606
Query: 307 DEKIEVHQEEVVAEVHVST---------------VEERTEEQKTEVE-ETAGSVPAEELV 350
EK ++ + + VH + V+E E K E E + S P ++
Sbjct: 607 CEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPV--IM 664
Query: 351 EMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQER 410
E E + K V+ E C E+P + +EK L K SE L S +
Sbjct: 665 EGVQEETDTRDVKRQVERSEICT--EEPQKQKSTLKNEKHLKKDD----SETPHLKSLLK 718
Query: 411 MKVQGSPLKKLFTSTGLK-KLSGK-KQKGK--RGGGDEESGEHTQVPADSPDSQEEQKGE 466
+V+ S K T + KLS K K KG GDE ++ ++ ++Q +
Sbjct: 719 KEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQ 778
Query: 467 SSASSPEEPEEITCL--EKGLAEVQQDGE--------AEEGATSDGEKKREGVTPWASFK 516
+ SS ++ E + E+ L+ + +DG+ +E + KK ++ + K
Sbjct: 779 TKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLS---AEK 835
Query: 517 KMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEP--KPEE---P 571
K R S+ K+ K TL + SE + +M + + KPEE
Sbjct: 836 TKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHK 895
Query: 572 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 631
+++ S+ E L+ SK + ++ + E G ++A DKE T+
Sbjct: 896 EKRRTKSLLEEKLVLKSKSKTQGKQVKVVETE----LQEGATKQATTPKPDKEKNTEEND 951
Query: 632 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK-SKLEEKSEDSIAGSG 690
+ Q + E P S+ S ++ + R K +K + KS+ +
Sbjct: 952 SEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTR 1011
Query: 691 VEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVP 750
+E D K S K I KK+ + K DD D V
Sbjct: 1012 LERKLSDGH--KSRSLKHSSKDI----KKKDENKS---------------DDKDGKEVDS 1050
Query: 751 LSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEE 810
E ME + +++ E +S+E+++ + + A ++ + ++ +
Sbjct: 1051 SHEKARGNSSLMEKKLSRRLCENRRGS----LSQEMAKGEEKLAANTLSTPSGSSLQRPK 1106
Query: 811 RSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLP-ENREARGDTVVS 869
+S EP+E +++E + E V E + + + EN + + V
Sbjct: 1107 KSGDMTLIPEQEPME-IDSEPGV--ENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQ 1163
Query: 870 EAELTPEAVTAAETAGPLGAEEGTEASA-AEETTEMVSAVSQLTDSPDTTEEATPVQE-- 926
+ EL + TA GT ++ +E+ + S +++ + P ++
Sbjct: 1164 KDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEP 1223
Query: 927 VEGGVPDIE-EQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEA 985
+ G ++ + E + +L A +E + + L T E V Q A E +
Sbjct: 1224 IHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTAAEEHVAQG--DATLEHSTNLDSS 1281
Query: 986 SGLKKETDVVLKVDAQEAKTEPFTQGKVV-----GQTTPESFEKAPQVTESIESSELVTT 1040
L T V L+ ++ + P + V T+P P + ++ SE++ T
Sbjct: 1282 PSLSSVTVVPLR-ESYDPDVIPLFDKRTVLEGSTASTSPADHSALPNQSLTVRESEVLKT 1340
Query: 1041 CQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGT-TQKDEIVEIHEE 1099
+DS+ G D A + T K I E H+
Sbjct: 1341 ----------------------------SDSKEGGEGFTVDTPAKASITSKRHIPEAHQA 1372
Query: 1100 NEVASGTQSG-----GTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1154
+ G Q G++ V + E V + + E L+ T K +V
Sbjct: 1373 T-LLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIK-ATV 1430
Query: 1155 ETVSILSKTEGTQ-------EADQYADE---KTKDVPFFEGLEGSI-DTGITVSREKVTE 1203
E K +G ++YA+ K K P G + D I V R
Sbjct: 1431 EN----GKKDGIAVDHVVGLNTEKYAETVKLKHKRSP------GKVKDISIDVERRNENS 1480
Query: 1204 VALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHE 1263
G+ A + P E+ V TE + V ++
Sbjct: 1481 EVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVAT----STEGKDKDVTLSPVKAG 1536
Query: 1264 TAVTVSEEV--SKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASF 1321
A T S E S+ L ++ +G + + + P +G E + CT +
Sbjct: 1537 PATTTSSETRQSEVALPCTSIEADEGLI-IGTHSRNNPLHVGAEASECTVFAAAEEGGAV 1595
Query: 1322 TLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDC 1381
AE E L T + GE+ E A A E + A H +
Sbjct: 1596 VTEGFAESETFLTST----KEGESGECAVA-----ESEDRAADLLAVHAVKIEANVNSVV 1646
Query: 1382 QAKSTPVIVSATTKK----GLSSD---LEGEKTTSLKWKSDEVDEQVACQEVKVSVAIED 1434
+ + SA +++ LS D +EG T + +SD + S++ E+
Sbjct: 1647 TEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSISSEE 1706
Query: 1435 LEPENGILELETKSSKLVQNIIQTAV----DQFVRTEETATEMLTSELQTQAHVIKADSQ 1490
++ G + + + T D FV T + T A V+ D+
Sbjct: 1707 VDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVLGDND 1766
Query: 1491 -DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDI--SKDMSEASEKTMTVE 1547
G +EG+ S D T SA + T G+ + S+D SE + E
Sbjct: 1767 APPGTSASQEGD---GSVNDGTEGESAVTSTGITEDGEGPASCTGSEDSSEGFAISSESE 1823
Query: 1548 VEGSTVNDQQL--EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDD 1605
G + D + E +P G P DD E I S +EDE+G+D
Sbjct: 1824 ENGESAMDSTVAKEGTNVPLVAAG--------PCDD------EGIVTSTGAKEEDEEGED 1869
Query: 1606 VDDPENQNSALADTDASGGLTKES 1629
V + + + GL +ES
Sbjct: 1870 VVTSTGRGNEIGHASTCTGLGEES 1893
Score = 77.0 bits (188), Expect = 1e-13
Identities = 339/1758 (19%), Positives = 640/1758 (36%), Gaps = 233/1758 (13%)
Query: 4 TITITVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQ 63
T T T +R SED++ DKE +T D +G E P+ E+ +EE+
Sbjct: 243 TDTSTDKERTSEDMA----DKEKSTA-----DSGGEGLETAPKS-EEFSDLPCPVEEIKN 292
Query: 64 PTESQANDIGFKKVFKFVGFKFTVKK-DKTEK-PDTVQLLTVKKDEGEGAAGAGDHKDPS 121
T+ N I K + + K DK EK PD+ + KK++ E DH S
Sbjct: 293 YTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKS 352
Query: 122 LGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSK 181
E K + KQ+ EK E+LK P+E K + K + +
Sbjct: 353 ----EDTQKVKDEKQAKEKEVESLKL---------PSE--------KNSNKAKTVEGTKE 391
Query: 182 SAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEE 241
S V T T T + SF + E+EV S+ +E E D E+
Sbjct: 392 DFSLIDSDVDGLTDITVSSVHTSDLS------SFEEDTEEEVVTSDSMEEGEITSDDEEK 445
Query: 242 DGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQG----PSEEK 297
+ + + ++ +SE H+P L Y K S+++++ Q E++
Sbjct: 446 NKQNKTKTQTSDSSEGKTKSVRHAYVHKPYL---YSKYYSDSDDELTVEQRRQSIAKEKE 502
Query: 298 PAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQ 357
L ++ EK+E +++ E+T+ KT+ + SV EE EP+
Sbjct: 503 ERLLRRQINREKLEEKRKQKA---------EKTKSSKTK-GQGRSSVDLEESSTKSLEPK 552
Query: 358 EAEPAKELVK-----LKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMK 412
A KE++K K+ +S + ++ + K K + E L + E +
Sbjct: 553 AAR-IKEVLKERKVLEKKVALSKKRKKDSRNVEENSK---KKQQYEEDSKETLKTSEHCE 608
Query: 413 VQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSP 472
+ K+ +S LK + K + K ES V + +S+ E++ + S+P
Sbjct: 609 KE-----KISSSKELKHVHAKSEPSKPARRLSESLH--VVDENKNESKLEREHKRRTSTP 661
Query: 473 EEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKK--MVTP--KKRVRRP 528
E + E +V++ E E T + +K++ + KK TP K +++
Sbjct: 662 VIMEGVQ-EETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKE 720
Query: 529 SESDKE-DELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICV 587
+S KE E +K S S + G E E KV+ ++
Sbjct: 721 VKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENI-------- 772
Query: 588 GSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPE 647
K+ + SSD++ K+ + +K GKD + ++ I+ +
Sbjct: 773 --QKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERR 830
Query: 648 QAGSPTEGEGVSTWESFKRL-----------VTPRKKSKSKLEEKSEDSIAGSGVEHSTP 696
+ T+ E S S ++ +T +++S+S E+K D + + + P
Sbjct: 831 LSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKC-DMDSTNMDSNLKP 889
Query: 697 DTEPGKEESWVS--IKKFIPGRRKKRPDGKQ---EQAPVEDAGPTGANEDDSDVPAVVPL 751
+ KE+ +++ + + K + GKQ + +++ A D
Sbjct: 890 EEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEE 949
Query: 752 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVA------DGTRAA 805
++ + + K+E + +++ +P + A+ + + H +A D +
Sbjct: 950 NDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTS 1009
Query: 806 TIIEER-SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARG 864
T +E + S S S+ + ++ + +++ +EV + E L E + +R
Sbjct: 1010 TRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRR 1069
Query: 865 DTVVSEAELTPEAVTAAE--TAGPLGAEEGTEASAAEETTEMVSAVSQ---LTDSPDTTE 919
L+ E E A L G+ +++ +M Q DS E
Sbjct: 1070 LCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVE 1129
Query: 920 EATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERP 979
V + + + +Q+ ++ + Q + V+++ T + +
Sbjct: 1130 NVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGV 1189
Query: 980 EEQAEASGLKKETDVVLKVDAQEA-------KTEPFTQG----KVVGQTTPESFEKAPQV 1028
+E + T + K+ Q A + EP +G + +T AP
Sbjct: 1190 NSNSEKHADHRST-LTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSE 1248
Query: 1029 TESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTT 1088
+ ++ + T + G + +E + DS +P+ S P+ + P
Sbjct: 1249 NDRVQKNLKNTAAEEHVAQG----DATLEHSTNLDS--SPSLSSVT-VVPLRESYDP--- 1298
Query: 1089 QKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHT 1148
+++ + ++ V G+ A PA P S V + E + S ++ E
Sbjct: 1299 ---DVIPLFDKRTVLE-----GSTASTSPADHSALPNQSLTVRESEVLKTSDSKEGGEGF 1350
Query: 1149 DKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKG 1208
+ + SI SK EA Q K L GS TG+ V E +T+
Sbjct: 1351 TVDTPAK-ASITSKRH-IPEAHQATLLDGKQGKVIMPL-GSKLTGVIVENENITK----- 1402
Query: 1209 EGTEEAECKKDDALELQSHAKSP-PSPVER--------EMVVQVEREKTEAEPTHVNEEK 1259
EG KK++ L + + K + VE + VV + EK + K
Sbjct: 1403 EGGLVDMAKKENDLNAEPNLKQTIKATVENGKKDGIAVDHVVGLNTEK------YAETVK 1456
Query: 1260 LEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCL----GQEEAVCTKIQVQ 1315
L+H+ + +++S + + +D S+ GS P L GQ E V T +
Sbjct: 1457 LKHKRSPGKVKDISIDVERRNENSEVD----TSAGSGSAPSVLHQRNGQTEDVATGPRRA 1512
Query: 1316 SSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDF--------- 1366
+ T T +++ L T + E + + L S E +E
Sbjct: 1513 EKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNN 1572
Query: 1367 AAHPGEDAVPTGPDCQAKSTPVIVS---ATTKKGLSSDLEGEK-TTSLKWKSDEVDEQVA 1422
H G +A A+ +V+ A ++ L+S EGE ++ D + +A
Sbjct: 1573 PLHVGAEASECTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLA 1632
Query: 1423 CQEVKVSVAIEDL---EPENGILELE---------TKSSKLVQNIIQTAVDQFVRTEETA 1470
VK+ + + E ++ + ++ S++V+ I F+ E+
Sbjct: 1633 VHAVKIEANVNSVVTEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTI-----TFISEVESD 1687
Query: 1471 TEMLTSELQTQAHVIKADSQDA--------GQETEKEGEEPQASAQDET------PITSA 1516
+ ++ + +A I ++ D G + E EG A+ + +T A
Sbjct: 1688 GAVTSAGTEIRAGSISSEEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGA 1747
Query: 1517 --KEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGT 1574
+EE T G D ++ + V T + + + + EG + T
Sbjct: 1748 GPREERMVTGAGVVLGDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCT 1807
Query: 1575 KSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNG 1634
S +G A+ +E E + D E N L A+G E T+
Sbjct: 1808 GSEDSSEGFAISSES------EENGESAMDSTVAKEGTNVPLV---AAGPCDDEGIVTST 1858
Query: 1635 PKQKEKEDAQEVELQEGK 1652
++E E+ ++V G+
Sbjct: 1859 GAKEEDEEGEDVVTSTGR 1876
Score = 69.3 bits (168), Expect = 3e-11
Identities = 186/896 (20%), Positives = 347/896 (38%), Gaps = 142/896 (15%)
Query: 846 EEEPPT--VTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTE 903
+E+P T +T+ +P T A + +A++ ET L E ASAA +TE
Sbjct: 176 DEKPDTSLITQGVP--------TPGPSANVANDAMSILETITSLNQE----ASAARASTE 223
Query: 904 MVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGG 963
T + T+E A+ + ++ER ++++ A+K K + G G
Sbjct: 224 --------TSNAKTSERASKKLPSQPTTDTSTDKERTSEDM----ADKEKSTADSGGEG- 270
Query: 964 PEDVLQPVQRAE--AERPEEQAEASGLKKETD--VVLKVDAQEAKTEPFTQGKVVGQTTP 1019
L+ ++E ++ P E KE + ++L D Q+ +E + G+ P
Sbjct: 271 ----LETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKP 326
Query: 1020 ESFEKAPQVTESIESSE--LVTTCQAETLAGVKSQEMVMEQAIPPDSVETPT-------- 1069
+S EK + E E +E + ++E VK ++ E+ + +S++ P+
Sbjct: 327 DSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV--ESLKLPSEKNSNKAK 384
Query: 1070 ------------DSETDGSTPV-------ADFDAPGTTQKDEIV--EIHEENEVASGTQ- 1107
DS+ DG T + +D + ++E+V + EE E+ S +
Sbjct: 385 TVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEE 444
Query: 1108 --------------SGGTEAEAVPAQKERPPAPSSFVF---QEETKEQSKMEDTLEHTDK 1150
S G A +P S + E T EQ + E ++
Sbjct: 445 KNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEER 504
Query: 1151 EVSVETVSILSKTEGTQEADQYADEKTK-----DVPFFEGLEGSIDTGITVSREKVTEVA 1205
+ + + + Q+A++ KTK V E S++ +E + E
Sbjct: 505 LLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERK 564
Query: 1206 LKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETA 1265
+ + ++ +K D+ ++ ++K E E E E ++E L+H A
Sbjct: 565 VLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKE-LKHVHA 623
Query: 1266 VTVSEEVSKQLLQTVNVPIIDGAKEVSSLE-------GSPPPCLGQEEAVCTKIQVQSSE 1318
+ + +++L ++++V +D K S LE +P G +E T+ + E
Sbjct: 624 KSEPSKPARRLSESLHV--VDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVE 681
Query: 1319 ASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEE-KSSEKNEDFAAHPGEDAVPT 1377
S T +++K + L+ ++ P L+ +E KSS++ + P ED +
Sbjct: 682 RSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSV 741
Query: 1378 ----GPDCQAKSTPVIVSATTKKGLSSDLEGEK-TTSLKWKSDEVDEQVA--CQEVKVSV 1430
DC K+ +++KGL + +K + K SD+ E+ + E K+SV
Sbjct: 742 KHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSV 801
Query: 1431 AIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1490
+D +P + + II+T D+ VR E E S +T+A S
Sbjct: 802 LGKDGKP-------------VSEYIIKT--DENVRKENNKKERRLSAEKTKAEHKSRRSS 846
Query: 1491 DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEG 1550
D+ + + G + + + SES + + D S +M + V E
Sbjct: 847 DSKIQKDSLGSKQHG--------ITLQRRSESYSEDKCDMD-STNMDSNLKPEEVVHKEK 897
Query: 1551 STVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKED-EKGDDVDDP 1609
E++VL S+ + G K V + L E K PK D EK + +D
Sbjct: 898 RRTKSLLEEKLVLKSKSKTQGKQVKVVETE-----LQEGATKQATTPKPDKEKNTEENDS 952
Query: 1610 ENQNSALADT---DASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAIT 1662
E Q + + + +G ++ +K+ + +L K +SDK T
Sbjct: 953 EKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDST 1008
Score = 50.1 bits (118), Expect = 2e-05
Identities = 210/1044 (20%), Positives = 356/1044 (34%), Gaps = 166/1044 (15%)
Query: 137 STEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGS 196
+TEK ET+K + SP +++ E E E + S + S S + G
Sbjct: 1447 NTEKYAETVKLKHKR---SPGKVKDISIDV--ERRNENSEVDTSAGSGSAPSVLHQRNGQ 1501
Query: 197 TFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASE 256
T T R+ ++ V S + K+++ + + G A S + SE
Sbjct: 1502 TEDV-----------ATGPRRAEKTSVATSTEGKDKDVT-LSPVKAGPATTTSSETRQSE 1549
Query: 257 QAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEE 316
A P E+ E + G+ S P + E + + EE
Sbjct: 1550 VALPCTSIEA----------------DEGLIIGTH--SRNNPLHVGAEASECTVFAAAEE 1591
Query: 317 VVAEVHVSTVEERTEEQKTEVEETAGSVPAE------ELVEMDAEPQEAEPAKELVKLKE 370
A V E T T+ E+ AE +L+ + A EA + + K+
Sbjct: 1592 GGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANVNSVVTEEKD 1651
Query: 371 TCVSGEDPTQGAD--LSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLK 428
V+ + D LS D +++ EG ++ + + S + G+ ++ S +
Sbjct: 1652 DAVTSAGSEEKCDGSLSRDSEIV----EGTITFISEVESDGAVTSAGTEIRA--GSISSE 1705
Query: 429 KLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEV 488
++ G + R G +E+ S + + P E +T G V
Sbjct: 1706 EVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVT----GAGVV 1761
Query: 489 QQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSST 548
D +A G TS ++ V + VT D E S S
Sbjct: 1762 LGDNDAPPG-TSASQEGDGSVNDGTEGESAVTSTGITE-----DGEGPASCTGSEDSSEG 1815
Query: 549 ESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKA 608
+ +SE +E + +++ +E T+V L+ G D+EG +
Sbjct: 1816 FAISSESEENGESAMDSTVAKE-----GTNVP---LVAAGPC----------DDEGIVTS 1857
Query: 609 MGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWES----- 663
G + DE G+D T T + ++ G S+ G E EGV ES
Sbjct: 1858 TGAKEE--DEEGEDVVTST------GRGNEIGHASTC---TGLGEESEGVLICESAEGDS 1906
Query: 664 -----FKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWV--SIKKFIPGR 716
+ + + E + DS++G TE G +++ + S K +
Sbjct: 1907 QIGTVVEHVEAEAGAAIMNANENNVDSMSG---------TEKGSKDTDICSSAKGIVESS 1957
Query: 717 RKKRPDGKQEQAPVEDA--GP-TGANEDDSD----------VPAVVPLSEYDA-VEREKM 762
GK E PV GP T A D SD + + YD V E
Sbjct: 1958 VTSAVSGKDEVTPVPGGCEGPMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVP 2017
Query: 763 EAQQAQKS-AEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWI----S 817
E + A S +E+ ++ T V E E M A D T ++ ++ + +
Sbjct: 2018 ECEVAHTSPSEKEDEDIITSVENE--ECDGLMATTASGDITNQNSLAGGKNQGKVLIIST 2075
Query: 818 ASVTEPLEQVEA--------EAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVS 869
++ + QV A AL TEE +E + EE P+P GD
Sbjct: 2076 STTNDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEE---FEAPMPS--AVSGDDSQL 2130
Query: 870 EAELTPEAVTAAETAGPLGAE------EGTEASAAEETTEMVSAVSQLTDSPDTTEEATP 923
A + E A + +G E T AE + +AV + P A
Sbjct: 2131 TASRSEEKDECAMISTSIGEEFELPISSATTIKCAESLQPVAAAVEERATGPVLISTA-- 2188
Query: 924 VQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQA 983
+ EG +P + + L + +++ K+E L T E+ V E E+A
Sbjct: 2189 --DFEGPMPSAPPE---AESPLASTSKEEKDECALISTSIAEECEASVSGVVVESENERA 2243
Query: 984 EASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQA 1043
+K+ ++ + E P V P+ E P VT + E + T
Sbjct: 2244 GTVMEEKDGSGIISTSSVEDCEGP------VSSAVPQE-EGDPSVTPAEEMGD---TAMI 2293
Query: 1044 ETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVA 1103
T + +++ + + T T E + ++ HEEN++
Sbjct: 2294 STSTSEGCEAVMIGAVLQDEDRLTITRVEDLSDAAIISTSTAECMPISASIDRHEENQLT 2353
Query: 1104 SGTQSGGTEAEAVPAQKERPPAPS 1127
+ G + A K + P PS
Sbjct: 2354 ADNPEGNGDLSATEVSKHKVPMPS 2377
Score = 41.6 bits (96), Expect = 0.007
Identities = 137/685 (20%), Positives = 234/685 (34%), Gaps = 128/685 (18%)
Query: 100 LLTVKKDEGEGAAGAGDHKDPSLGAGE--AASKESEPKQSTEKPEETLKREQSHAEISPP 157
+L V +EG G HK PS G G A E E K E PE I P
Sbjct: 2399 VLAVSTEEGHN--GPSVHK-PSAGQGHPSAVCAEKEEKHGKECPE-----------IGPF 2444
Query: 158 AESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK 217
A GQ E++ + + SP T G + ++ G S
Sbjct: 2445 AGRGQKESTLHLINAEEKNVLLNSLQKEDKSPETGTAGGSSTASYSAGRGLEGNANSPAH 2504
Query: 218 PKEDEVEASEKKKEQEPE------------KVDTEEDGKAEVASEKLTASEQAHPQEPAE 265
+ E + + K+ K D + VA +EQ ++ +
Sbjct: 2505 LRGPEQTSGQTAKDPSVSIRYLAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLK 2564
Query: 266 SAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVST 325
++ ++ + K+ PS + PA + + K E Q+ + +
Sbjct: 2565 TSTTKCITGQESKIA-PSHTMIP---------PATYSVALLAPKCE--QDLTIKNDYSGK 2612
Query: 326 VEERTEEQKT-EVEETAGSVPAEE--LVEMDAEPQ------EAEPAKELVKLK------- 369
++ +KT + T S P E +V + +E E P L LK
Sbjct: 2613 WTDQASAEKTGDDNSTRKSFPEEGDIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKM 2672
Query: 370 ETCVSGEDPTQGADLSPDEKVLSKPPEGVVS-EVEMLSSQERMKVQGSPLKKLFTSTGLK 428
E V E+ G L+P E + P G+ + E L E + V+ S +
Sbjct: 2673 EAYVPSEEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNEEIHSES 2732
Query: 429 KLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKG-------ESSASSPEEPEEIT-C 480
G+ G++ + SG V AD + +EE++ + SS +EP++
Sbjct: 2733 YNKGEISSGRKDNAEAISGH--SVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDV 2790
Query: 481 LEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKV 540
L+ + Q+ E + E R+ +EL K
Sbjct: 2791 LDSRIETAQRQCPETEPHDTKEENSRD--------------------------LEELPKT 2824
Query: 541 KSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSS 600
S T S+T M+E+ + S E E+P++ D ++ S
Sbjct: 2825 SSETNSTTSRV---MEEKDEYSSSETTGEKPEQNDDDTI-------------------KS 2862
Query: 601 DEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVST 660
EE P + + G+ ++ + L + G + EQ+ S ++ + + T
Sbjct: 2863 QEEDQPIII------KRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQT 2916
Query: 661 WESFKRLVTPRKKSKSK--LEEKSEDSIAGSGVEHS-----TPDTEPGKEESWVSIKKFI 713
ES K +++S S EEK S+ G + + D E + E
Sbjct: 2917 DESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSD 2976
Query: 714 PGRRKKRPDGKQEQAPVEDAGPTGA 738
P KK + +E+ E+ P+GA
Sbjct: 2977 PVEDKKEQESDEEEEEEEEDEPSGA 3001
Score = 41.2 bits (95), Expect = 0.009
Identities = 87/421 (20%), Positives = 152/421 (36%), Gaps = 64/421 (15%)
Query: 11 QRDSEDVSKRDSDKE----MATKSAVVHDITDDGQEETP-------------EIIEQIPS 53
++ +D S R S E M T S+ ++ D G EE+P ++ +PS
Sbjct: 2620 EKTGDDNSTRKSFPEEGDIMVTVSSE-ENVCDIGNEESPLNVLGGLKLKANLKMEAYVPS 2678
Query: 54 SESNLEELTQPTESQAND--IGFKKVFK---FVGFKFTVKKDKTEKPDTVQLLTVKKDEG 108
E E+ P ES G ++ + V V+ + + + K G
Sbjct: 2679 EEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNK--G 2736
Query: 109 EGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQ------ 162
E ++G D+ + G S E++PK+ E+ KR++ +S E
Sbjct: 2737 EISSGRKDNAEAISGH----SVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLD 2792
Query: 163 -----AVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK 217
A +C E ++E S+ E +SET ST + + +T+ K
Sbjct: 2793 SRIETAQRQCPETEPHDTKEENSRDLEE-LPKTSSETNSTTSRVMEEKDEYSSSETTGEK 2851
Query: 218 PK---EDEVEASE-------KKKEQEPEKVDTE------EDGKAE---VASEKLTASEQA 258
P+ +D +++ E K+K P K E +D K + V E+ +S +
Sbjct: 2852 PEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKL 2911
Query: 259 HPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFD----EKIEVHQ 314
+ ES E E EE++ S KP T D E Q
Sbjct: 2912 KVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQ 2971
Query: 315 EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVS 374
+ V V +E EE++ E E+ +A+ + + + + + +E
Sbjct: 2972 KSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPP 3031
Query: 375 G 375
G
Sbjct: 3032 G 3032
Score = 40.4 bits (93), Expect = 0.015
Identities = 75/374 (20%), Positives = 146/374 (39%), Gaps = 49/374 (13%)
Query: 226 SEKKKEQE----PEKV-DTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVE 280
SE++K E PE + + G AE+ E L +E + + +E S Y K E
Sbjct: 2678 SEEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGE 2737
Query: 281 LPS-----EEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKT 335
+ S E +SG ++ K E+ E H + + H + E+ ++
Sbjct: 2738 ISSGRKDNAEAISGHSVEADPKEV--------EEEERHMPKRKRKQHYLSSEDEPDDNP- 2788
Query: 336 EVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGA-----DLSPDEKV 390
+V ++ + E + + E +++L +L +T T + S E
Sbjct: 2789 DVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETT 2848
Query: 391 LSKPPEGVVSEVEMLSSQER------MKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDE 444
KP + ++ + + SQE + +G P K +T K K G
Sbjct: 2849 GEKPEQ---NDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQS 2905
Query: 445 ESGEHTQV-PADSPDSQEEQKGESSASSPEEPEEI--TCLEKGLAEVQQDGEAEEGATSD 501
S +V D + + E S S+ + E+I + +G + +++ +S+
Sbjct: 2906 PSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSE 2965
Query: 502 GEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVK----SATLSSTESTASEMQE 557
E+KR+ K V+ ++ ESD+E+E ++ + T S+T S A +
Sbjct: 2966 PERKRQ---------KSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKT 3016
Query: 558 EMKGSVEEPKPEEP 571
++ S++ + P
Sbjct: 3017 QLSPSIKRKREVSP 3030
Score = 39.3 bits (90), Expect = 0.033
Identities = 47/203 (23%), Positives = 85/203 (41%), Gaps = 35/203 (17%)
Query: 6 TITVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEI-IEQIPSS---------E 55
TI + D + KR + + DD + +T + +EQ PSS E
Sbjct: 2859 TIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDE 2918
Query: 56 SNLEELTQPTESQANDIGFKKVFKFVGFK-------FTVKKD-KTEKPDTVQLLTV---- 103
SN E S +ND G +K+ V + TV D ++ +P+ + +V
Sbjct: 2919 SNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPV 2978
Query: 104 --KKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESG 161
KK++ + +D GA ++ SE ++S + ++KR++ E+SPP
Sbjct: 2979 EDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKR---EVSPPG--- 3032
Query: 162 QAVEECKEEGEEKQEKEPSKSAE 184
+ G+++ E+ P K A+
Sbjct: 3033 -----ARTRGQQRVEEAPVKKAK 3050
Score = 36.2 bits (82), Expect = 0.28
Identities = 50/205 (24%), Positives = 87/205 (42%), Gaps = 27/205 (13%)
Query: 1472 EMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSD 1531
E +TS L +A +A ++ + +T + + S P T + E T
Sbjct: 206 ETITS-LNQEASAARASTETSNAKTSERASKKLPSQ----PTTDTSTDKERT-------- 252
Query: 1532 ISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIE 1591
S+DM++ + T EG + E LP E TK E + LL + ++
Sbjct: 253 -SEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTK---EHNNLILLNKDVQ 308
Query: 1592 KSLVEPKE------DEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQE 1645
+ E K ++K D + E + T+ +K+S DT K K+++ A+E
Sbjct: 309 QESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQ--KVKDEKQAKE 366
Query: 1646 VELQEGKVHSE--SDKAITPQAQEE 1668
E++ K+ SE S+KA T + +E
Sbjct: 367 KEVESLKLPSEKNSNKAKTVEGTKE 391
>gi|148806928 hypothetical protein LOC57482 [Homo sapiens]
Length = 1233
Score = 77.4 bits (189), Expect = 1e-13
Identities = 249/1299 (19%), Positives = 459/1299 (35%), Gaps = 236/1299 (18%)
Query: 10 GQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIE--QIPSSESNLEELTQPTES 67
G+ E+ S E+ T+ +V ++ +TP + +P + S +EE P +
Sbjct: 65 GEASLEEDLFLTSPMEIVTQQDIVLSDAENKSSDTPSSLSPLNLPGAGSEMEEKVAPVKP 124
Query: 68 QANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEA 127
K+ F G +V D + L + D A HK
Sbjct: 125 SRP----KRHFSSAGTIESVNLD------AIPLAIARLDNS-----AAKHK--------L 161
Query: 128 ASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPT 187
A K KQ K L ++ H + G C ++ E +P+ E P
Sbjct: 162 AVKPK--KQRVSKKHRRLAQDPQHEQ------GGLESRPCLDQNGHPGEDKPTWHEEEP- 212
Query: 188 SPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKK--------------EQE 233
+P+ SE ++ + WR+ + K K + EA+EK++ E+
Sbjct: 213 NPLDSEEERRRQEDY------WRELEA--KCKRQKAEAAEKRRLEEQRLQALERRLWEEN 264
Query: 234 PEKVDTEEDGKAE---VASEKLTASEQAHPQE-PAESAHEPRLSAEYEKVELPSEEQVSG 289
+ EE+G+ + + +E+ EQ E P E R E E++E E +
Sbjct: 265 RRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQ 324
Query: 290 SQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEEL 349
+Q +EE+ +E+ +EE + EE E E+E ++
Sbjct: 325 AQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELE--------QQE 376
Query: 350 VEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEV-----EM 404
E+ P+ E E + E GE+ +G D + G +SE+ E
Sbjct: 377 AEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWR-------GQLSELLNDFEER 429
Query: 405 LSSQERMKVQG----SPLKKLFTSTGLKKLSGKKQKGKRG---GGDEESGEHTQVPADSP 457
L QER+K +G S + + ++Q+G+ G G D E + D+
Sbjct: 430 LEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDTE 489
Query: 458 DSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKK 517
+++ +A P E +E LE+G +K E + ++
Sbjct: 490 PLLKQEGPVEAAQPPVERKEAAALEQG-------------------RKVEELRWQEVDER 530
Query: 518 MVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPK-----PEEPK 572
P+ + S K+ KV + ++ + T + + +EPK P +
Sbjct: 531 QTMPRPYTFQVSSGGKQILFPKVNLSPVTPAKDTG------LTAAPQEPKAPKASPVQHA 584
Query: 573 RKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKAD---EAGKDKETGTDG 629
SV A++ G+ S ++ K++ G +K AG++ G
Sbjct: 585 LPSSLSVPHTAILVTGAQLCGPAVNLSQIKDTACKSLLGLEEKKHAEAPAGENPPRGPGD 644
Query: 630 ILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGS 689
AGS G + P Q SP+ ++ W S + + +S + E+ +
Sbjct: 645 ARAGS-------GKAKPRQE-SPSSASALAEWASIRSRILKNAESDPRSSERDQ------ 690
Query: 690 GVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAG----PTGANEDDSDV 745
PG E + GR R G Q + P +A P D
Sbjct: 691 --------LRPGDEST-------PRGRCDSR--GNQRKTPPVNAKFSIMPAWQKFSDGGT 733
Query: 746 PAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAA 805
+E +++ + M ++++A QP E+ K +S++H A +G + A
Sbjct: 734 ETSKQSTEAESIRKRPM-LGPSEETAPQPPPAGVRELGKGPEKSEMHREPADTTEGCKFA 792
Query: 806 TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGD 865
+ PS++ S+ P ++V+A E T ++ N A+ D
Sbjct: 793 KDL----PSFLVPSLPYP----------------PQKVVAHTEFTTSSDSETANGIAKPD 832
Query: 866 TVV--SEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDS-PDTTEEAT 922
V+ E + +P + T L + A ++ + S+ D+ P A
Sbjct: 833 PVMPGGEEKASPFGIKLRRTNYSL--RFNCDQQAEQKKKKRHSSTGDSADAGPPAAGSAR 890
Query: 923 PVQEVEGGV----PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAER 978
+E+EG P + ++ ++ + AE S GP P ++
Sbjct: 891 GEKEMEGVALKHGPSLPQERKQAPSTRRDSAEPSSSRSVPVAHPGP-----PPASSQTPA 945
Query: 979 PEEQAEAS--GLKKETDVVLKVDAQEAKTEPFTQ----------GKVVGQTTPESFEKAP 1026
PE A+ L ++ + K +Q P ++ + G+ PE E +
Sbjct: 946 PEHDKAANKMPLAQKPALAPKPTSQTPPASPLSKLSRPYLVELLSRRAGRPDPEPSEPSK 1005
Query: 1027 QVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPG 1086
+ ES + E + +E + P T E TP A G
Sbjct: 1006 EDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPEA-----G 1060
Query: 1087 TTQKDEIVEIH--EENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDT 1144
+K + H + +++ ++ + QK++ F Q+ T+E+ K
Sbjct: 1061 RKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQK-----GFREQQATREERKQARE 1115
Query: 1145 LEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEV 1204
+ +K +S E VS+ S G+ + GS+ + EK E
Sbjct: 1116 AKQAEK-LSKENVSV-SVQPGSSSVSR---------------AGSLHKSTALPEEKRPET 1158
Query: 1205 ALKGEGTEEAECKKDDAL----ELQSHAKSPPSPVEREM 1239
A+ E + KK + L ++ +PP+P+ +E+
Sbjct: 1159 AVSRLERRE-QLKKANTLPTSVTVEISDSAPPAPLVKEV 1196
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 74.7 bits (182), Expect = 7e-13
Identities = 191/939 (20%), Positives = 322/939 (34%), Gaps = 168/939 (17%)
Query: 88 KKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPS-----LGAGEAASKESEPKQSTEKPE 142
KK + P + + +++E E + S LGA +S + + K TEK
Sbjct: 74 KKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAG 133
Query: 143 ETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFF 202
+T P +G+ V ++ EPS A + T E GS F
Sbjct: 134 KT-------GNSMPHPATGKTVANLLSGKSPRKSAEPS--ANTTLVSETEEEGSV-PAFG 183
Query: 203 TQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQE 262
G ED +S+ +T+ +GK V ++ AS + +
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSD----------ETDVEGKPSVKPAQVKASSVSTKES 233
Query: 263 PAESAH---------EPRLSA----EYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK 309
PA A P++ ++ + P EE S +G E+ AP T +
Sbjct: 234 PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGT-----R 288
Query: 310 IEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLK 369
+V E + +V ++ + K G A + ++ + +P ++
Sbjct: 289 SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGA-----VASQTKAGKPEEDSESSS 343
Query: 370 ETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLS--SQERMKVQGSPLKKLFTSTGL 427
E E+ T A + +L G S+V S ++E + +P T +
Sbjct: 344 EESSDSEEETPAA-----KALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAV 398
Query: 428 KKLSGKKQKGKRGGGDEESGEHTQVPADS-PDSQEEQKGESSASSPEEPEEITC----LE 482
K K++ EES + PA + P + Q +SA + E P + +
Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458
Query: 483 KGLAEVQ-QDGEAEEGATSDGEKK---RE-------------------------GVTPWA 513
G A Q Q G+ EE + S E+ RE G+ P
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLG 518
Query: 514 SFKKMVTP-KKRVRRPS------ESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEP 566
V P K PS E D E ++ ++ + + QE+ G++ +
Sbjct: 519 KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQA 578
Query: 567 KPEE------PKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQK----- 615
KP P++ +V +A + +S+ S+D E P AM K
Sbjct: 579 KPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKI 638
Query: 616 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 675
K+T T A ++ G+ +P +AG+ T G S + P + S
Sbjct: 639 PQTKACPKKTNT---TASAKVAPVRVGTQAPRKAGTATSPAGSSPAVA-GGTQRPAEDSS 694
Query: 676 SKLEEKSEDSIAGSGVE-----------HSTPDTEPGKEESWVSIKKFIPGRRKKRPDGK 724
S E SE+ G V + P K +PG K P
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG--KTGPTVT 752
Query: 725 QEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK 784
Q +A ++ + E DS+ A P +V++ + +A A +A P K
Sbjct: 753 QVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGT----- 805
Query: 785 ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQ------------------ 826
+A AA ++RSPS + V P
Sbjct: 806 ----------ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 855
Query: 827 VEAEAALLTEE---VLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPE---AVTA 880
A+A EE E E +EEE T+ + P + + ++ A+ +P A T
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP 915
Query: 881 AETAGPLGAEEGTE---ASAAEETTEMVSAVSQLTDSPD 916
GP A+ G + S++EE+ A + +T + D
Sbjct: 916 PGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQD 954
Score = 63.9 bits (154), Expect = 1e-09
Identities = 203/992 (20%), Positives = 344/992 (34%), Gaps = 154/992 (15%)
Query: 486 AEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSAT- 544
+E+ + +AEE A +K R V+ SE ++E E + K+
Sbjct: 57 SELGRKRKAEEDAALQAKKTR------------VSDPISTSESSEEEEEAEAETAKATPR 104
Query: 545 LSSTESTA------SEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGS 598
L+ST S+ S M+E+ K E+ + A + G S +++ S
Sbjct: 105 LASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPS 164
Query: 599 SS-------DEEGGPKAMGGDHQ-------KADEAGKDKETGTDGI-LAGSQEHDPGQGS 643
++ +EEG A G + +AD + +D + +D + G P Q
Sbjct: 165 ANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVK 224
Query: 644 SS-------PEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTP 696
+S P + +P G+ K P K K EE+SE S GS E P
Sbjct: 225 ASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAP 284
Query: 697 DTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDA 756
G + +K + R P A P A S A P + ++
Sbjct: 285 ---AGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSES 341
Query: 757 VEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWI 816
E ++++ E P KA + SQV +A + R P
Sbjct: 342 SSEESSDSEE-----ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA--APAPPGKT 394
Query: 817 SASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEP---LPENREARGDTVVS---- 869
+V + E + + E E +EEE P +P P+ R A S
Sbjct: 395 GPAVAKAQAGKREEDSQSSSE----ESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKG 450
Query: 870 EAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEG 929
A P A +G +E S++EE+ A++ + + P+ G
Sbjct: 451 AAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAM-----NAAQVKPL----G 501
Query: 930 GVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLK 989
P ++ L A V PG GP V + E E E +E S
Sbjct: 502 KSPQVKPASTMGMGPLGKGAGPVP-----PGKVGPATPSAQVGKWE-EDSESSSEESSDS 555
Query: 990 KETDVVLKV-DAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQA--ETL 1046
+ +V V AQE Q K +KA V +++ + + ++ E+
Sbjct: 556 SDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESS 615
Query: 1047 AGVKSQE----MVMEQAIP----PDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHE 1098
S+E M QA P P + P + T S VA V
Sbjct: 616 DSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR----------VGTQA 665
Query: 1099 ENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVS 1158
+ + T G+ + AV +RP SS + E+S E+ E T V+V
Sbjct: 666 PRKAGTATSPAGS-SPAVAGGTQRPAEDSS------SSEESDSEE--EKTGLAVTVGQAK 716
Query: 1159 ILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTG---ITVSREKVTEVALKGEGTEEAE 1215
+ K G Q K VP ++GS+ G + + T +K E E++E
Sbjct: 717 SVGK--GLQ-------VKAASVP----VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 763
Query: 1216 CKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETA-----VTVSE 1270
++++ + + A SP ++ V++ + +A P + + VT +
Sbjct: 764 SSEEES-DSEEAAASP-----AQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAA 817
Query: 1271 EVSKQLLQTVNVPIIDGAKEVSSLEG-SPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE 1329
+ ++ V P+ + G + P +G+ A + Q E S + ++
Sbjct: 818 QAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDS 877
Query: 1330 EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVI 1389
E+ A + +G+T + A +E P + A PT P K+ P
Sbjct: 878 EEEAETLAQVKPSGKTHQIRAALAPAKES-----------PRKGAAPTPP---GKTGPSA 923
Query: 1390 VSA-----TTKKGLSSDLEGEKTTSLKWKSDE 1416
A + SD +GE ++ D+
Sbjct: 924 AQAGKQDDSGSSSEESDSDGEAPAAVTSAQDQ 955
Score = 55.1 bits (131), Expect = 6e-07
Identities = 186/949 (19%), Positives = 313/949 (32%), Gaps = 140/949 (14%)
Query: 815 WISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELT 874
W S + E +AAL ++ +P + +E E EA +T A+ T
Sbjct: 53 WQQTSELGRKRKAEEDAALQAKKT------RVSDPISTSESSEEEEEAEAET----AKAT 102
Query: 875 PEAVTAAETAGPLGAE-EGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPD 933
P A+ + LGA+ + A+ TE P T + + +
Sbjct: 103 PRL--ASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKS 160
Query: 934 IEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETD 993
E T + + +EE +P G +P + + + S ETD
Sbjct: 161 AEPSANTT------LVSETEEEGSVPAFGA---AAKPGMVSAGQADSSSEDTSSSSDETD 211
Query: 994 VVLK-------VDAQEAKTEPFTQGKV------VGQTTPE-------SFEKAPQVTESIE 1033
V K V A T+ K VG TP+ ++A + E E
Sbjct: 212 VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESE 271
Query: 1034 SSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETD-GSTPVADFDAPGTTQKDE 1092
SSE + + E AG +SQ E+ + + P G+TP A + +
Sbjct: 272 SSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTK 331
Query: 1093 IVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEV 1152
+ E++E +S +S +E E A+ S Q E +
Sbjct: 332 AGKPEEDSE-SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAP 390
Query: 1153 SVETVSILSKTE-GTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGT 1211
+T ++K + G +E D + + D S + ++ ++
Sbjct: 391 PGKTGPAVAKAQAGKREEDSQSSSEESD---------SEEEAPAQAKPSGKAPQVRAASA 441
Query: 1212 EEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEE 1271
E + A K+ P+ + ++ Q E ++ +E + + E L A V
Sbjct: 442 PAKESPRKGAAPAPPR-KTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500
Query: 1272 VSKQLLQTVNV----PIIDGAKEVSSLE---GSPPPCLGQEEAVCTKIQVQSSEAS---F 1321
++ + P+ GA V + +P +G+ E +SS++S
Sbjct: 501 GKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEV 560
Query: 1322 TLTAAAEEEKVLGETANILETGETLEPAG---------AHLVLEEK------SSEKNEDF 1366
A +EK LG NIL+ T PA A V EK SSE++ D
Sbjct: 561 PTAVAPAQEKSLG---NILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS 617
Query: 1367 AAH------------------PGEDAVP--TGPDCQAKSTPVIVS--ATTKKGLSSDLEG 1404
A P A P T AK PV V A K G ++ G
Sbjct: 618 ADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAG 677
Query: 1405 EKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQT---AVD 1461
++ + +E D E E L + +K V +Q +V
Sbjct: 678 SSPAVAGGTQRPAEDSSSSEE-------SDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 730
Query: 1462 QFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESE 1521
+ +L + +KA+ Q+ + +E+E + +A+A TS K+
Sbjct: 731 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 790
Query: 1522 STAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVL-PSEEEGGGAGTKSVPED 1580
A + +K A K +T + + +++ V P G SVP
Sbjct: 791 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 850
Query: 1581 DGHALLAERIEKSLVEPKEDE-KGDDVDDPENQNSALADTDASG---------------- 1623
A + + P+ED ++ D E + LA SG
Sbjct: 851 GKAVATAAQAQTG---PEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESP 907
Query: 1624 --GLTKESPDTNGPK--QKEKEDAQEVELQEGKVHSESDKAITPQAQEE 1668
G P GP Q K+D +E E+ A+T +E
Sbjct: 908 RKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQDQE 956
Score = 38.5 bits (88), Expect = 0.056
Identities = 74/379 (19%), Positives = 145/379 (38%), Gaps = 50/379 (13%)
Query: 1329 EEKVLGETANILETGETL-EPAGAHLVLE-------EKSSEKNEDFAAHPGEDAVPTGPD 1380
+EK ET +TG ++ PA V KS+E + + + + P
Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPA 181
Query: 1381 CQAKSTPVIVSA---------TTKKGLSSDLEGE---KTTSLKWKSDEVDEQVACQEVKV 1428
A + P +VSA T+ +D+EG+ K +K S E A +
Sbjct: 182 FGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPA 241
Query: 1429 SVAIEDLEPE--NGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIK 1486
+ D+ P+ G L ++ K + + ++ +EE A S+++ +++
Sbjct: 242 PGKVGDVTPQVKGGALPPAKRAKKPEEE--SESSEEGSESEEEAPAGTRSQVKASEKILQ 299
Query: 1487 ADSQDA-GQETEKEGEEP-----QASAQDETPITSAKEESESTAVGQAHSDISKDMSEAS 1540
+ A + T +G P + +T +E+SES++ S S++ + A+
Sbjct: 300 VRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSS---EESSDSEEETPAA 356
Query: 1541 EKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKED 1600
+ + + G T Q+ P++E + P G A + K+ +E+
Sbjct: 357 KALLQAKASGKT---SQVGAASAPAKESPRKGAAPAPPGKTGPA-----VAKAQAGKREE 408
Query: 1601 EKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKA 1660
+ ++ +++ A A SG ++P KE ++G + K
Sbjct: 409 DSQSSSEESDSEEEAPAQAKPSG----KAPQVRAASAPAKESP-----RKGAAPAPPRKT 459
Query: 1661 ITPQAQEELQKQERESAKS 1679
AQ ++ KQE +S S
Sbjct: 460 GPAAAQVQVGKQEEDSRSS 478
Score = 31.6 bits (70), Expect = 6.8
Identities = 49/229 (21%), Positives = 79/229 (34%), Gaps = 31/229 (13%)
Query: 1481 QAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTA------VGQAHSDIS- 1533
QA D+ + ET+ EG+ AQ + S KE A VG +
Sbjct: 195 QADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKG 254
Query: 1534 ------------KDMSEASEKTMTVEVEGSTVNDQQLE------EVVLPSEEEGGGAGTK 1575
++ SE+SE+ E E Q++ +V S G G
Sbjct: 255 GALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG 314
Query: 1576 SVPEDDGHA-LLAERIEKSLVEPKEDEKGDDVDDPENQN---SALADTDASGGLTKESPD 1631
+ P G A +A + + E + ++ D E + AL ASG ++
Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374
Query: 1632 TNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1680
+ K+ ++ A GK KA + +E+ Q ES E
Sbjct: 375 SAPAKESPRKGA--APAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE 421
Score = 31.2 bits (69), Expect = 8.9
Identities = 48/197 (24%), Positives = 82/197 (41%), Gaps = 29/197 (14%)
Query: 1495 ETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGS-TV 1553
ETE+EG P A + + SA GQA S S+D S +S++T +VEG +V
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSA---------GQADSS-SEDTSSSSDET---DVEGKPSV 218
Query: 1554 NDQQLEEVVLPSEEE-------GGGAGTKSVPEDDGHAL-LAERIEKSLVEPKEDEKGDD 1605
Q++ + ++E G P+ G AL A+R +K E + E+G +
Sbjct: 219 KPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSE 278
Query: 1606 VDD--PENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITP 1663
++ P S + ++ + S G K A GK + + +
Sbjct: 279 SEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPA-----PPGKAGAVASQTKAG 333
Query: 1664 QAQEELQKQERESAKSE 1680
+ +E+ + ES+ SE
Sbjct: 334 KPEEDSESSSEESSDSE 350
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 74.3 bits (181), Expect = 9e-13
Identities = 124/482 (25%), Positives = 189/482 (39%), Gaps = 77/482 (15%)
Query: 213 TSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRL 272
+ +KPK VEA K K Q + E+ K E ++ + A +E A S E +
Sbjct: 434 SKIQKPK---VEAP-KLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKK 489
Query: 273 SAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEE 332
A EK E P E EE+ A + V EV +EE E EE +E
Sbjct: 490 EAAEEKEEEPEAE---------EEEVAAKKSPVKATAPEVKEEEGEKE------EEEGQE 534
Query: 333 QKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLS 392
++ E +E A S AEE +E KE + +E E + A+ ++KV
Sbjct: 535 EEEEEDEGAKSDQAEE----GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE 590
Query: 393 KPPEGVVSEVEMLSSQ--ERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHT 450
K E V ++ E+++ E+ + SP+ K S ++KGK
Sbjct: 591 KSEE-VATKEELVADAKVEKPEKAKSPVPK----------SPVEEKGK------------ 627
Query: 451 QVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVT 510
+ P S E+KG+S P+ P E EKG + V + E+G K +
Sbjct: 628 ---SPVPKSPVEEKGKSPV--PKSPVE----EKGKSPVPKSPVEEKG------KSPVSKS 672
Query: 511 PWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEE 570
P K PK V E+ + E+ K + E + +E+++ E+PK
Sbjct: 673 PVEEKAKSPVPKSPV---EEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVP 729
Query: 571 PKRKVDTSVSWEALICVGSSKK--RARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTD 628
K+K ++ V EA+ V + K + + EEG P + +KA G +E G+D
Sbjct: 730 EKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSD 789
Query: 629 GILAGSQEHDPG-----QGSSSPEQ----AGSPTEGEGVSTWESFKRLVTPRKKSKSKLE 679
GS++ D +G EQ GS E E KK K E
Sbjct: 790 KGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSE 849
Query: 680 EK 681
EK
Sbjct: 850 EK 851
Score = 70.9 bits (172), Expect = 1e-11
Identities = 119/495 (24%), Positives = 186/495 (37%), Gaps = 116/495 (23%)
Query: 139 EKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAE---SPTSPVTSETG 195
E E K E A + E +++E K+E E++E+EP E + SPV +
Sbjct: 459 ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAP 518
Query: 196 STFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTAS 255
K +E E E E ++E+E E + D E SEK +S
Sbjct: 519 EV-------------------KEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS 559
Query: 256 EQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATE---VFDEKIEV 312
E+ +E + E AE E+ E E++V EEK +AT+ V D K+E
Sbjct: 560 EK---EEGEQEEGETEAEAEGEEAEAKEEKKV-------EEKSEEVATKEELVADAKVE- 608
Query: 313 HQEEVVAEVHVSTVEERTEE--QKTEVEETAGS-VPAEELVEMDAEPQEAEPAKELVKLK 369
E+ + V S VEE+ + K+ VEE S VP + E P P +E
Sbjct: 609 KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE----- 663
Query: 370 ETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKK 429
G+ P + + +EK S P+ V E
Sbjct: 664 ----KGKSPVSKSPV--EEKAKSPVPKSPVEEA--------------------------- 690
Query: 430 LSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQ 489
K K + G G+++ E +V +E K E E+P+++ +K + V+
Sbjct: 691 ----KSKAEVGKGEQKEEEEKEV-------KEAPKEEKVEKKEEKPKDVPEKKKAESPVK 739
Query: 490 QDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTE 549
++ AE +VT K V+ E + ++E ++ E
Sbjct: 740 EEAVAE----------------------VVTITKSVKVHLEKETKEEGKPLQQE--KEKE 775
Query: 550 STASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAM 609
E E +GS K + RK D +V+ E ++ +GS +EE G
Sbjct: 776 KAGGEGGSEEEGS---DKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTN 832
Query: 610 GGDHQKADE-AGKDK 623
G D ADE G DK
Sbjct: 833 GLDLSPADEKKGGDK 847
Score = 68.9 bits (167), Expect = 4e-11
Identities = 154/765 (20%), Positives = 291/765 (38%), Gaps = 80/765 (10%)
Query: 221 DEVEASEK---KKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAE------SAHEPR 271
D+ EA+ + K +E V E D K + +++ H +E A+ ++H
Sbjct: 197 DDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITV 256
Query: 272 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 331
+Y K ++ + + SQ S +HQ E + + + E E
Sbjct: 257 ERKDYLKTDISTALKEIRSQLESHSDQ------------NMHQAEEWFKCRYAKLTEAAE 304
Query: 332 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKV- 390
+ K + + AE ++ ++ E E + + E +S + DLS +
Sbjct: 305 QNKEAIRSAKEEI-AEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTI 363
Query: 391 --LSKPPEGVVSEV--------EMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRG 440
L G E+ ++L+ + + ++ + +KL L G++ +
Sbjct: 364 QQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKL--------LEGEETRFSTF 415
Query: 441 GGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATS 500
G +T P + S+ ++ E ++ K + E+ ++ + E+ S
Sbjct: 416 AGSITGPLYTHRPPITISSKIQKP-------KVEAPKLKVQHKFVEEIIEETKVED-EKS 467
Query: 501 DGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMK 560
+ E+ +T + M KK E + E E ++V +A S ++TA E++EE +
Sbjct: 468 EMEEALTAITEELAVS-MKEEKKEAAEEKEEEPEAEEEEV-AAKKSPVKATAPEVKEE-E 524
Query: 561 GSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAG 620
G EE + +E + + D + GS K+ + ++E G + ++A+
Sbjct: 525 GEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKE 584
Query: 621 KDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEE 680
+ K +A +E PE+A SP V E K V KS +EE
Sbjct: 585 EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVE--EKGKSPV-----PKSPVEE 637
Query: 681 KSEDSIAGSGVEH---STPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDA---- 733
K + + S VE S P +E+ + K + K P K +PVE+A
Sbjct: 638 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPK---SPVEEAKSKA 694
Query: 734 --GPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQP-EQKAATEVSKELSESQ 790
G E++ P E + EK + +K AE P +++A EV +
Sbjct: 695 EVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVK 754
Query: 791 VHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPP 850
VH+ +G E+ S E ++ A+ + + + EV +EE
Sbjct: 755 VHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK-GAKGSRKEDIAVNGEVEGKEEVE 813
Query: 851 TVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQ 910
T+ RE V + +L+P A E G ++ E +T E +++
Sbjct: 814 QETKEKGSGREEEKGVVTNGLDLSP----ADEKK---GGDKSEEKVVVTKTVEKITSEGG 866
Query: 911 LTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEE 955
+ T+ T Q+VE EE+ T++V + + + +E
Sbjct: 867 DGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKE 911
Score = 58.9 bits (141), Expect = 4e-08
Identities = 104/430 (24%), Positives = 157/430 (36%), Gaps = 48/430 (11%)
Query: 801 GTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENR 860
G+ + R P IS+ + +P +VEA + + +E E+I E + V + E
Sbjct: 417 GSITGPLYTHRPPITISSKIQKP--KVEAPKLKVQHKFVE-EIIEETK---VEDEKSEME 470
Query: 861 EARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEE 920
EA +T E + + AEE E AEE +P+ EE
Sbjct: 471 EAL-------TAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEE 523
Query: 921 ATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPE 980
+E EG EE+E + AE+ E + G+ E+ Q EAE
Sbjct: 524 EGEKEEEEGQ----EEEEEEDEGAKSDQAEEGGSEKE--GSSEKEEGEQEEGETEAEAEG 577
Query: 981 EQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTT 1040
E+AEA KK +E E T+ ++V E EKA E +
Sbjct: 578 EEAEAKEEKK---------VEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKS 628
Query: 1041 CQAETLAGVKSQEMVMEQAIPPDSVETPTDS--ETDGSTPVA----DFDAPGTTQKDEIV 1094
++ K + V + + S E G +PV+ + A K +
Sbjct: 629 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVE 688
Query: 1095 EIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1154
E + EV G Q E E A KE +E+ K+ + + +E
Sbjct: 689 EAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK----EEKPKDVPEKKKAESPVKEEAVA 744
Query: 1155 ETVSILS------KTEGTQEADQYADEKTKDVPFFEG---LEGSIDTGITVSREKVTEVA 1205
E V+I + E +E EK K+ EG EGS D G SR++ V
Sbjct: 745 EVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGS-DKGAKGSRKEDIAVN 803
Query: 1206 LKGEGTEEAE 1215
+ EG EE E
Sbjct: 804 GEVEGKEEVE 813
Score = 57.4 bits (137), Expect = 1e-07
Identities = 101/409 (24%), Positives = 155/409 (37%), Gaps = 46/409 (11%)
Query: 4 TITITVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQ 63
T + V ++ + + + ++E + V + PE+ E+ E EE
Sbjct: 477 TEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEE----EGEKEEEEG 532
Query: 64 PTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLG 123
E + D G K G + E+ + + T + EGE A + K
Sbjct: 533 QEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS 592
Query: 124 AGEAASKESEPKQSTEKPEETL---------KREQSHAEISPPAESGQA------VEEC- 167
A +E EKPE+ ++ +S SP E G++ VEE
Sbjct: 593 EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 652
Query: 168 -----KEEGEEKQEKEPSKSA--ESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK--- 217
K EEK + SKS E SPV K G G +K+ ++
Sbjct: 653 KSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVG-KGEQKEEEEKEVKE 711
Query: 218 -PKEDEVEASEKKKEQEPEKVDTEEDGKAEVASE--KLTASEQAHPQEPAESAHEPRLSA 274
PKE++VE E+K + PEK E K E +E +T S + H ++ + +P L
Sbjct: 712 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKP-LQQ 770
Query: 275 EYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQE-EVVAEVHVSTVEERT--E 331
E EK E+ G G EE A E I V+ E E EV T E+ + E
Sbjct: 771 EKEK------EKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGRE 824
Query: 332 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQ 380
E+K V PA+E D ++ K + K+ T G+ T+
Sbjct: 825 EEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKI--TSEGGDGATK 871
Score = 55.1 bits (131), Expect = 6e-07
Identities = 148/783 (18%), Positives = 282/783 (36%), Gaps = 85/783 (10%)
Query: 933 DIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGLK 989
D +QE R + K + QL ED+ + +R E E R + +A L+
Sbjct: 148 DAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALR 207
Query: 990 KETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTE------SIESSELVTTCQA 1043
K+ + V + K Q +V + E A + + ++E + + T +
Sbjct: 208 KDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDIS 267
Query: 1044 ETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEE-NEV 1102
L ++SQ + S + +E A K+ I EE E
Sbjct: 268 TALKEIRSQ-------LESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEY 320
Query: 1103 ASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK 1162
QS E E+V KE S + + + S +DT++ + E+ +K
Sbjct: 321 RRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRG------TK 374
Query: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1222
E + +Y D ++ ++D I R+ L+GE T +
Sbjct: 375 WEMARHLREYQD--------LLNVKMALDIEIAAYRK-----LLEGEETRFSTFAGSITG 421
Query: 1223 ELQSHAKSPPSPVEREMVVQVEREKTEA--------------EPTHVNEEKLEHETAVT- 1267
L +H PP + + +++ K EA E T V +EK E E A+T
Sbjct: 422 PLYTHR--PPITISSK----IQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTA 475
Query: 1268 VSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAA 1327
++EE++ + + K+ ++ E P +EE K V+++
Sbjct: 476 ITEELAVSMKEE---------KKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGE 526
Query: 1328 EEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTP 1387
+EE+ E + G + A +E SSEK E +A G + +AK
Sbjct: 527 KEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEK 586
Query: 1388 VIVSAT----TKKGLSSDLEGEKTTSLKWK--SDEVDEQVACQEVKVSVAIEDLEPENGI 1441
+ + TK+ L +D + EK K V+E+ K V + P
Sbjct: 587 KVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 646
Query: 1442 LELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGE 1501
E S + ++ ++ V + + ++ K+ ++ E ++E E
Sbjct: 647 PVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEE 706
Query: 1502 EPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEV 1561
+ A E + +E+ + + K+ + A T+T V+ + + E
Sbjct: 707 KEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGK 766
Query: 1562 VLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDA 1621
L E+E AG + E++G A+ K + + +G + + E + +
Sbjct: 767 PLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 826
Query: 1622 SGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSEL 1681
G +T D + +K+ D E +K + + E++ + + A +
Sbjct: 827 KGVVT-NGLDLSPADEKKGGDKSE------------EKVVVTKTVEKITSEGGDGATKYI 873
Query: 1682 TES 1684
T+S
Sbjct: 874 TKS 876
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 74.3 bits (181), Expect = 9e-13
Identities = 124/482 (25%), Positives = 189/482 (39%), Gaps = 77/482 (15%)
Query: 213 TSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRL 272
+ +KPK VEA K K Q + E+ K E ++ + A +E A S E +
Sbjct: 58 SKIQKPK---VEAP-KLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKK 113
Query: 273 SAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEE 332
A EK E P E EE+ A + V EV +EE E EE +E
Sbjct: 114 EAAEEKEEEPEAE---------EEEVAAKKSPVKATAPEVKEEEGEKE------EEEGQE 158
Query: 333 QKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLS 392
++ E +E A S AEE +E KE + +E E + A+ ++KV
Sbjct: 159 EEEEEDEGAKSDQAEE----GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE 214
Query: 393 KPPEGVVSEVEMLSSQ--ERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHT 450
K E V ++ E+++ E+ + SP+ K S ++KGK
Sbjct: 215 KSEE-VATKEELVADAKVEKPEKAKSPVPK----------SPVEEKGK------------ 251
Query: 451 QVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVT 510
+ P S E+KG+S P+ P E EKG + V + E+G K +
Sbjct: 252 ---SPVPKSPVEEKGKSPV--PKSPVE----EKGKSPVPKSPVEEKG------KSPVSKS 296
Query: 511 PWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEE 570
P K PK V E+ + E+ K + E + +E+++ E+PK
Sbjct: 297 PVEEKAKSPVPKSPV---EEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVP 353
Query: 571 PKRKVDTSVSWEALICVGSSKK--RARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTD 628
K+K ++ V EA+ V + K + + EEG P + +KA G +E G+D
Sbjct: 354 EKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSD 413
Query: 629 GILAGSQEHDPG-----QGSSSPEQ----AGSPTEGEGVSTWESFKRLVTPRKKSKSKLE 679
GS++ D +G EQ GS E E KK K E
Sbjct: 414 KGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSE 473
Query: 680 EK 681
EK
Sbjct: 474 EK 475
Score = 70.9 bits (172), Expect = 1e-11
Identities = 119/495 (24%), Positives = 186/495 (37%), Gaps = 116/495 (23%)
Query: 139 EKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAE---SPTSPVTSETG 195
E E K E A + E +++E K+E E++E+EP E + SPV +
Sbjct: 83 ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAP 142
Query: 196 STFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTAS 255
K +E E E E ++E+E E + D E SEK +S
Sbjct: 143 EV-------------------KEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS 183
Query: 256 EQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATE---VFDEKIEV 312
E+ +E + E AE E+ E E++V EEK +AT+ V D K+E
Sbjct: 184 EK---EEGEQEEGETEAEAEGEEAEAKEEKKV-------EEKSEEVATKEELVADAKVE- 232
Query: 313 HQEEVVAEVHVSTVEERTEE--QKTEVEETAGS-VPAEELVEMDAEPQEAEPAKELVKLK 369
E+ + V S VEE+ + K+ VEE S VP + E P P +E
Sbjct: 233 KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE----- 287
Query: 370 ETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKK 429
G+ P + + +EK S P+ V E
Sbjct: 288 ----KGKSPVSKSPV--EEKAKSPVPKSPVEEA--------------------------- 314
Query: 430 LSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQ 489
K K + G G+++ E +V +E K E E+P+++ +K + V+
Sbjct: 315 ----KSKAEVGKGEQKEEEEKEV-------KEAPKEEKVEKKEEKPKDVPEKKKAESPVK 363
Query: 490 QDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTE 549
++ AE +VT K V+ E + ++E ++ E
Sbjct: 364 EEAVAE----------------------VVTITKSVKVHLEKETKEEGKPLQQE--KEKE 399
Query: 550 STASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAM 609
E E +GS K + RK D +V+ E ++ +GS +EE G
Sbjct: 400 KAGGEGGSEEEGS---DKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTN 456
Query: 610 GGDHQKADE-AGKDK 623
G D ADE G DK
Sbjct: 457 GLDLSPADEKKGGDK 471
Score = 68.2 bits (165), Expect = 7e-11
Identities = 109/492 (22%), Positives = 195/492 (39%), Gaps = 32/492 (6%)
Query: 474 EPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDK 533
E ++ K + E+ ++ + E+ S+ E+ +T + M KK E +
Sbjct: 66 EAPKLKVQHKFVEEIIEETKVED-EKSEMEEALTAITEELAVS-MKEEKKEAAEEKEEEP 123
Query: 534 EDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKR 593
E E ++V +A S ++TA E++EE +G EE + +E + + D + GS K+
Sbjct: 124 EAEEEEV-AAKKSPVKATAPEVKEE-EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEG 181
Query: 594 ARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPT 653
+ ++E G + ++A+ + K +A +E PE+A SP
Sbjct: 182 SSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPV 241
Query: 654 EGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEH---STPDTEPGKEESWVSIK 710
V E K V KS +EEK + + S VE S P +E+ +
Sbjct: 242 PKSPVE--EKGKSPV-----PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVS 294
Query: 711 KFIPGRRKKRPDGKQEQAPVEDA------GPTGANEDDSDVPAVVPLSEYDAVEREKMEA 764
K + K P K +PVE+A G E++ P E + EK +
Sbjct: 295 KSPVEEKAKSPVPK---SPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD 351
Query: 765 QQAQKSAEQP-EQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEP 823
+K AE P +++A EV +VH+ +G E+ S E
Sbjct: 352 VPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEG 411
Query: 824 LEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAET 883
++ A+ + + + EV +EE T+ RE V + +L+P A E
Sbjct: 412 SDK-GAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSP----ADEK 466
Query: 884 AGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQE 943
G ++ E +T E +++ + T+ T Q+VE EE+ T++
Sbjct: 467 K---GGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKK 523
Query: 944 VLQAVAEKVKEE 955
V + + + +E
Sbjct: 524 VEKVTSHAIVKE 535
Score = 58.9 bits (141), Expect = 4e-08
Identities = 104/430 (24%), Positives = 157/430 (36%), Gaps = 48/430 (11%)
Query: 801 GTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENR 860
G+ + R P IS+ + +P +VEA + + +E E+I E + V + E
Sbjct: 41 GSITGPLYTHRPPITISSKIQKP--KVEAPKLKVQHKFVE-EIIEETK---VEDEKSEME 94
Query: 861 EARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEE 920
EA +T E + + AEE E AEE +P+ EE
Sbjct: 95 EAL-------TAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEE 147
Query: 921 ATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPE 980
+E EG EE+E + AE+ E + G+ E+ Q EAE
Sbjct: 148 EGEKEEEEGQ----EEEEEEDEGAKSDQAEEGGSEKE--GSSEKEEGEQEEGETEAEAEG 201
Query: 981 EQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTT 1040
E+AEA KK +E E T+ ++V E EKA E +
Sbjct: 202 EEAEAKEEKK---------VEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKS 252
Query: 1041 CQAETLAGVKSQEMVMEQAIPPDSVETPTDS--ETDGSTPVA----DFDAPGTTQKDEIV 1094
++ K + V + + S E G +PV+ + A K +
Sbjct: 253 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVE 312
Query: 1095 EIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1154
E + EV G Q E E A KE +E+ K+ + + +E
Sbjct: 313 EAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK----EEKPKDVPEKKKAESPVKEEAVA 368
Query: 1155 ETVSILS------KTEGTQEADQYADEKTKDVPFFEG---LEGSIDTGITVSREKVTEVA 1205
E V+I + E +E EK K+ EG EGS D G SR++ V
Sbjct: 369 EVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGS-DKGAKGSRKEDIAVN 427
Query: 1206 LKGEGTEEAE 1215
+ EG EE E
Sbjct: 428 GEVEGKEEVE 437
Score = 57.4 bits (137), Expect = 1e-07
Identities = 101/409 (24%), Positives = 155/409 (37%), Gaps = 46/409 (11%)
Query: 4 TITITVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQ 63
T + V ++ + + + ++E + V + PE+ E+ E EE
Sbjct: 101 TEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEE----EGEKEEEEG 156
Query: 64 PTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLG 123
E + D G K G + E+ + + T + EGE A + K
Sbjct: 157 QEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS 216
Query: 124 AGEAASKESEPKQSTEKPEETL---------KREQSHAEISPPAESGQA------VEEC- 167
A +E EKPE+ ++ +S SP E G++ VEE
Sbjct: 217 EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 276
Query: 168 -----KEEGEEKQEKEPSKSA--ESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK--- 217
K EEK + SKS E SPV K G G +K+ ++
Sbjct: 277 KSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVG-KGEQKEEEEKEVKE 335
Query: 218 -PKEDEVEASEKKKEQEPEKVDTEEDGKAEVASE--KLTASEQAHPQEPAESAHEPRLSA 274
PKE++VE E+K + PEK E K E +E +T S + H ++ + +P L
Sbjct: 336 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKP-LQQ 394
Query: 275 EYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQE-EVVAEVHVSTVEERT--E 331
E EK E+ G G EE A E I V+ E E EV T E+ + E
Sbjct: 395 EKEK------EKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGRE 448
Query: 332 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQ 380
E+K V PA+E D ++ K + K+ T G+ T+
Sbjct: 449 EEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKI--TSEGGDGATK 495
Score = 56.2 bits (134), Expect = 3e-07
Identities = 117/507 (23%), Positives = 193/507 (38%), Gaps = 89/507 (17%)
Query: 1117 PAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEK 1176
P RPP S Q+ E K++ ++H E +E + DEK
Sbjct: 46 PLYTHRPPITISSKIQKPKVEAPKLK--VQHKFVEEIIEETKV-------------EDEK 90
Query: 1177 TKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVE 1236
++ ++ +T E++ V++K E E AE K+++ + + SPV+
Sbjct: 91 SE-----------MEEALTAITEELA-VSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVK 138
Query: 1237 REMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEG 1296
E E + E EE+ E E A + E +G E EG
Sbjct: 139 ATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAE--------------EGGSE---KEG 181
Query: 1297 SPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETL---------- 1346
S G++E T+ + + EA A+EEK + E + + T E L
Sbjct: 182 SSEKEEGEQEEGETEAEAEGEEAE------AKEEKKVEEKSEEVATKEELVADAKVEKPE 235
Query: 1347 ---EPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKG---LSS 1400
P V E+ S + G+ VP P + +PV S +KG +S
Sbjct: 236 KAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSK 295
Query: 1401 DLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQ---NIIQ 1457
EK S KS V+E + EV E+ E E E K K + ++ +
Sbjct: 296 SPVEEKAKSPVPKS-PVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPE 354
Query: 1458 TAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAK 1517
+ EE E++T + H+ K ++++ G+ ++E E+ +A + S +
Sbjct: 355 KKKAESPVKEEAVAEVVTITKSVKVHLEK-ETKEEGKPLQQEKEKEKAGGEG----GSEE 409
Query: 1518 EESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGA--GTK 1575
E S+ A G DI+ + EVEG +Q+ +E EEE G G
Sbjct: 410 EGSDKGAKGSRKEDIA----------VNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLD 459
Query: 1576 SVPEDDGHALLAERIEKSLVEPKEDEK 1602
P D+ ++ E+ +V K EK
Sbjct: 460 LSPADEKKG--GDKSEEKVVVTKTVEK 484
Score = 43.9 bits (102), Expect = 0.001
Identities = 86/463 (18%), Positives = 174/463 (37%), Gaps = 35/463 (7%)
Query: 1229 KSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVT-VSEEVSKQLLQTVNVPIIDG 1287
++P V+ + V ++ E T V +EK E E A+T ++EE++ + +
Sbjct: 66 EAPKLKVQHKFVEEI------IEETKVEDEKSEMEEALTAITEELAVSMKEE-------- 111
Query: 1288 AKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLE 1347
K+ ++ E P +EE K V+++ +EE+ E + G +
Sbjct: 112 -KKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 170
Query: 1348 PAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSAT----TKKGLSSDLE 1403
A +E SSEK E +A G + +AK + + TK+ L +D +
Sbjct: 171 QAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAK 230
Query: 1404 GEKTTSLKWK--SDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVD 1461
EK K V+E+ K V + P E S + ++ ++
Sbjct: 231 VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 290
Query: 1462 QFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESE 1521
V + + ++ K+ ++ E ++E E+ A E + +E+ +
Sbjct: 291 SPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPK 350
Query: 1522 STAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDD 1581
+ K+ + A T+T V+ + + E L E+E AG + E++
Sbjct: 351 DVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEE 410
Query: 1582 GHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKE 1641
G A+ K + + +G + + E + + G +T D + +K+
Sbjct: 411 GSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVT-NGLDLSPADEKKGG 469
Query: 1642 DAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES 1684
D E +K + + E++ + + A +T+S
Sbjct: 470 DKSE------------EKVVVTKTVEKITSEGGDGATKYITKS 500
Score = 40.8 bits (94), Expect = 0.011
Identities = 62/305 (20%), Positives = 116/305 (38%), Gaps = 42/305 (13%)
Query: 1407 TTSLKWKSDEVDE-QVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVR 1465
T S K + +V+ ++ Q V IE+ + E+ E+E + + + + + ++
Sbjct: 55 TISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKE 114
Query: 1466 TEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDE--------------- 1510
E E +E + A A + E+EGE+ + Q+E
Sbjct: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174
Query: 1511 ---------TPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEE- 1560
+EE E+ A + +K+ + EK+ V + V D ++E+
Sbjct: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234
Query: 1561 -------VVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQN 1613
P EE+G KS E+ G + + KS VE EKG P++
Sbjct: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKS----PVPKSPVE----EKGKS-PVPKSPV 285
Query: 1614 SALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQE 1673
+ S +E + PK +E + E+ +G+ E +K + +EE +++
Sbjct: 286 EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK 345
Query: 1674 RESAK 1678
E K
Sbjct: 346 EEKPK 350
Score = 32.0 bits (71), Expect = 5.2
Identities = 36/143 (25%), Positives = 63/143 (44%), Gaps = 21/143 (14%)
Query: 1546 VEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDD 1605
VE V + +EE++ EE KS E+ A+ E + S+ E K++ +
Sbjct: 65 VEAPKLKVQHKFVEEII----EETKVEDEKSEMEEALTAI-TEELAVSMKEEKKEAAEEK 119
Query: 1606 VDDPENQNSALADTDASGGLTKESP-DTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQ 1664
++PE + +A K+SP P+ KE+E +E E + + E + A + Q
Sbjct: 120 EEEPEAEEEEVA--------AKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQ 171
Query: 1665 AQE-------ELQKQERESAKSE 1680
A+E +K+E E + E
Sbjct: 172 AEEGGSEKEGSSEKEEGEQEEGE 194
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 73.6 bits (179), Expect = 2e-12
Identities = 115/543 (21%), Positives = 205/543 (37%), Gaps = 85/543 (15%)
Query: 89 KDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKP----EET 144
+D +E+ + VQ KK A K L G+AA+K SE S E EE
Sbjct: 88 EDSSEEEEEVQGPPAKK-------AAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEED 140
Query: 145 LKREQSHAEISPPAESGQA----VEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKK 200
K++ + P A++ +A + + + E EP K+ + +PVT + +
Sbjct: 141 QKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPP 200
Query: 201 FFTQGWAGWRKKTSFRKPK-EDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAH 259
K + PK + AS D E+ KA +K +Q
Sbjct: 201 -----------KPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVV 249
Query: 260 PQEPAESAHEP-RLSAEYEKVELPSEEQ----VSGSQGPSEEKPAP--------LATEVF 306
+ P ++A P R S+ E EE+ + GP P P L T+
Sbjct: 250 AKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPP 309
Query: 307 DEKIEVHQ-----EEVVAEVHVSTVEERTEEQKTEVEE-TAGSVPAEELVEMDAEPQEAE 360
+ +E Q E+ E S+ EE+ K V + T PA++ E ++ +++
Sbjct: 310 KKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSD 369
Query: 361 -------PAKELVKLKETCVSGEDPTQGADLSP----------DEKVLSKPPEGVVSEVE 403
P+K K + T+ + P +K+L++ + SE E
Sbjct: 370 SSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEE 429
Query: 404 MLSSQE-RMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEE 462
SS+E + K + K T+ L K+ +G D S +DS S+EE
Sbjct: 430 SSSSEEEKTKKMVATTKPKATAKAALSLPAKQ--APQGSRDSSSD------SDSSSSEEE 481
Query: 463 QKGESSASSPEEPEEIT---------CLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWA 513
++ S ++ ++P+++ +KG AE +++ + + EK + +P
Sbjct: 482 EEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRP 541
Query: 514 SFKKM----VTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPE 569
K + + S++E+E K + +S + S Q E E P+ +
Sbjct: 542 QAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAK 601
Query: 570 EPK 572
+ K
Sbjct: 602 KIK 604
Score = 64.7 bits (156), Expect = 7e-10
Identities = 122/574 (21%), Positives = 227/574 (39%), Gaps = 94/574 (16%)
Query: 3 GTITITVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQE-ETPEIIEQIPSSESNLEEL 61
G + S + S D D+E K V + + + P + S+S+
Sbjct: 117 GKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSE 176
Query: 62 TQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPS 121
+P ++Q I V K +T+ P K G+ A+ + S
Sbjct: 177 DEPPKNQKPKITPVTV-----------KAQTKAPPKPARAAPKIANGKAASSS------S 219
Query: 122 LGAGEAASKESEPKQSTEKPEETLKREQSHAEI-----SPPAESGQAVEECKEEGEEKQE 176
+ ++S +SE +++ P++T+ ++Q A+ + P + E+ + EE+++
Sbjct: 220 SSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSD-EEEEQ 278
Query: 177 KEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEK 236
K+P K+ P S V + KK + G +K ++P VE+SE ++
Sbjct: 279 KKPMKNKPGPYSSVPPPSAPPPKK--SLGTQPPKKAVEKQQP----VESSEDSSDESDSS 332
Query: 237 VDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEE 296
+ E+ + K T ++ ++ AES+ + S E E PS+ +G+ S
Sbjct: 333 SEEEKKPPTKAVVSKAT-TKPPPAKKAAESSSDSSDSDSSEDDEAPSKP--AGTTKNSSN 389
Query: 297 KPA-----PLATEVFDEKIEVH--QEEVVAEVHVSTVEERT---EEQKTE---------- 336
KPA P K V Q+ + + S+ EE + EE+KT+
Sbjct: 390 KPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKA 449
Query: 337 VEETAGSVPAEELVE-----------MDAEPQEAEPAKELVKLKETCVSG-EDPTQGADL 384
+ A S+PA++ + +E +E + +K VK K V+G P++ A
Sbjct: 450 TAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASA 509
Query: 385 SPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDE 444
+ S S E +E++K +GSP + + G L+ Q GK E
Sbjct: 510 KKGKAESSNSSSSDDSSEE---EEEKLKGKGSPRPQAPKANGTSALTA--QNGKAAKNSE 564
Query: 445 ESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEK 504
E +EE+K +++ + + G + ++ EA + A + K
Sbjct: 565 E--------------EEEEKKKAA---------VVVSKSGSLKKRKQNEAAKEAETPQAK 601
Query: 505 KREGVTPWASFKKMVTPKKRVRRPSESDKEDELD 538
K + TP +F K +KR P +E+E++
Sbjct: 602 KIKLQTP-NTFPKRKKGEKRASSPFRRVREEEIE 634
Score = 63.5 bits (153), Expect = 2e-09
Identities = 110/534 (20%), Positives = 199/534 (37%), Gaps = 51/534 (9%)
Query: 219 KEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQA--------HPQEPAESAHEP 270
+E+EV+ KK P K GKA + + ++SE++ ++P + +P
Sbjct: 93 EEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKP 152
Query: 271 RLSAEY---EKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVE 327
+ A +K + + S S+ + P T V K + A
Sbjct: 153 QAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPV-TVKAQTKAPPKPARAAPKIAN 211
Query: 328 ERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELV---KLKETCVSGEDPTQGADL 384
+ + ++ S +EE + A P++ P K++V +K + D
Sbjct: 212 GKAASSSSSSSSSSSSDDSEE-EKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDS 270
Query: 385 SPDEKVLSKPP----EGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRG 440
S DE+ K P G S V S+ P KK + KK K+Q
Sbjct: 271 SSDEEEEQKKPMKNKPGPYSSVPPPSA--------PPPKKSLGTQPPKKAVEKQQ----- 317
Query: 441 GGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATS 500
ES E + +DS S+EE+K + A + + +K +++
Sbjct: 318 --PVESSEDSSDESDS-SSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDD 374
Query: 501 DGEKKREGVTPWASFKKMVTPKKRVRRPSESDKE-----DELDKVKSATLSSTESTASEM 555
+ K G T +S K VT K +P+ + K+ +L K+ + SS E ++S
Sbjct: 375 EAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSE 434
Query: 556 QEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQK 615
+E+ K V KP+ + + AL + R SSSD + + + +
Sbjct: 435 EEKTKKMVATTKPK--------ATAKAALSLPAKQAPQGSRDSSSDSDSS-SSEEEEEKT 485
Query: 616 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 675
+ A K K G A S+ +G + + S ++ E K +PR ++
Sbjct: 486 SKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSS-SDDSSEEEEEKLKGKGSPRPQAP 544
Query: 676 SKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAP 729
+ + G ++S + E K+ + V K +RK+ K+ + P
Sbjct: 545 KANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETP 598
Score = 61.6 bits (148), Expect = 6e-09
Identities = 108/506 (21%), Positives = 185/506 (36%), Gaps = 35/506 (6%)
Query: 406 SSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKG 465
SS+E +VQG P KK + K++ K + S E + S D EE +
Sbjct: 90 SSEEEEEVQGPPAKK--AAVPAKRVGLPPGKAAAKASESSSSEES-----SDDDDEEDQK 142
Query: 466 ESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREG-VTPWASFKKMVTPKKR 524
+ +P+ D +++ + + K ++ +TP + P K
Sbjct: 143 KQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPK- 201
Query: 525 VRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEAL 584
P+ + + K S++ SS+ S++S+ EE K + PK PK++V +A
Sbjct: 202 ---PARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAAT-PKKTVPKKQVVAKAPVKAA 257
Query: 585 ICVGSSKKRARRGSSSDEEGGPKAM---GGDHQKADEAG---KDKETGTDGILAGSQEHD 638
+ SS +EE K M G + K GT ++
Sbjct: 258 TTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQ 317
Query: 639 PGQGS-SSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPD 697
P + S S +++ S +E E ++ T + K E S DS S + S D
Sbjct: 318 PVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDS---SDSDSSEDD 374
Query: 698 TEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAV 757
P K P K P K AP + P G + A SE
Sbjct: 375 EAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQ---PVGGGQKLLTRKADSSSSE---E 428
Query: 758 EREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWIS 817
E E ++ +K + KA + + L Q + + + +++ EE + S
Sbjct: 429 ESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKS 488
Query: 818 ASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEA 877
A +P Q A A ++ ++ AE + ++ E E + + + P+A
Sbjct: 489 AVKKKP--QKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEE---EKLKGKGSPRPQA 543
Query: 878 VTAAETAGPLGAEEGTEASAAEETTE 903
A T+ L A+ G A +EE E
Sbjct: 544 PKANGTSA-LTAQNGKAAKNSEEEEE 568
Score = 47.0 bits (110), Expect = 2e-04
Identities = 44/162 (27%), Positives = 72/162 (44%), Gaps = 29/162 (17%)
Query: 93 EKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEA-ASKESEPKQSTEKPEETLKREQSH 151
E+ + VKK + A GA K S G+A +S S S+E+ EE LK + S
Sbjct: 480 EEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSP 539
Query: 152 AEISP--------PAESGQAVEECKEEGEEK----------------QEKEPSKSAESP- 186
+P A++G+A + +EE EEK ++ E +K AE+P
Sbjct: 540 RPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQ 599
Query: 187 TSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEK 228
+ +T +TF K + R + FR+ +E+E+E +
Sbjct: 600 AKKIKLQTPNTFPK---RKKGEKRASSPFRRVREEEIEVDSR 638
Score = 44.3 bits (103), Expect = 0.001
Identities = 122/630 (19%), Positives = 225/630 (35%), Gaps = 90/630 (14%)
Query: 833 LLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEG 892
L + +V ER++ A + + ++ + E P A AA A +G G
Sbjct: 58 LKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPG 117
Query: 893 TEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKV 952
A+ A E++ ++EE++ D +E++++ Q V + V +
Sbjct: 118 KAAAKASESS--------------SSEESSD---------DDDEEDQKKQPVQKGVKPQA 154
Query: 953 KEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGK 1012
K P D +E E P+ Q K T V +K + K
Sbjct: 155 KAAKAPPKKAKSSDS-DSDSSSEDEPPKNQKP-----KITPVTVKAQTKAPPKPARAAPK 208
Query: 1013 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1072
+ S + + S +S E E A + + +Q + V+ T
Sbjct: 209 IANGKAASSSSSSSSSSSSDDSEE-------EKAAATPKKTVPKKQVVAKAPVKAAT--- 258
Query: 1073 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1132
TP + + DE E + + G S A P +K P +
Sbjct: 259 ----TPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVE 314
Query: 1133 EETKEQSKMEDTLEHTDKEVSVE----TVSILSKTEGTQEADQYADEKTKDVPFFEGLEG 1188
++ +S ED+ + +D E T +++SK TK P + E
Sbjct: 315 KQQPVESS-EDSSDESDSSSEEEKKPPTKAVVSKAT------------TKPPPAKKAAES 361
Query: 1189 SIDTGITVSREKVTEVALKGEGTEE------AECKKDDALELQSHAKSPPSPVEREMVVQ 1242
S D+ + S E E K GT + A K A++ + K P ++ + +
Sbjct: 362 SSDSSDSDSSED-DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRK 420
Query: 1243 VEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCL 1302
+ +E E + EEK + A T + +K L G+++ SS S
Sbjct: 421 ADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSS--DSDSSSS 478
Query: 1303 GQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEK 1362
+EE +K V+ + +KV G A +PA A E S+
Sbjct: 479 EEEEEKTSKSAVKK-----------KPQKVAGGAA-------PSKPASAKKGKAESSNSS 520
Query: 1363 NEDFAAHPGEDAV--PTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQ 1420
+ D ++ E+ + P QA + T + G ++ E+ K + V +
Sbjct: 521 SSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKS 580
Query: 1421 VACQEVKVSVAIEDLE-PENGILELETKSS 1449
+ ++ K + A ++ E P+ ++L+T ++
Sbjct: 581 GSLKKRKQNEAAKEAETPQAKKIKLQTPNT 610
Score = 43.5 bits (101), Expect = 0.002
Identities = 119/617 (19%), Positives = 207/617 (33%), Gaps = 114/617 (18%)
Query: 1078 PVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKER-PPAPSSFVFQEETK 1136
PVA + D EE EV Q + AVPA++ PP ++ E +
Sbjct: 73 PVAKKAKKKASSSDSEDSSEEEEEV----QGPPAKKAAVPAKRVGLPPGKAAAKASESSS 128
Query: 1137 EQSKMEDTLEHTDKEVSVE----------------TVSILSKTEGTQEADQYADEKTKDV 1180
+ +D E K+ V+ S S ++ + E + ++K K
Sbjct: 129 SEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKIT 188
Query: 1181 PFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMV 1240
P + + K+ + + D E + A +P V ++ V
Sbjct: 189 PVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQV 248
Query: 1241 VQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTV-----NVPIIDGAKEVSSLE 1295
V K PT + E + + EE K+ ++ +VP SL
Sbjct: 249 VAKAPVKAATTPTRKSSSS---EDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLG 305
Query: 1296 GSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVL 1355
PP ++AV + V+SSE S + ++ EE+ T ++ T P
Sbjct: 306 TQPP-----KKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPA----- 355
Query: 1356 EEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSD 1415
+K++E + D + + D +A S P + TTK + K+ +
Sbjct: 356 -KKAAESSSDSSDSDSSE------DDEAPSKP---AGTTKNSSNKPAVTTKSPA------ 399
Query: 1416 EVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLT 1475
V A +P G +L T+
Sbjct: 400 ------------VKPAAAPKQPVGGGQKLLTR---------------------------- 419
Query: 1476 SELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKD 1535
KADS + +E+ EE T + + + S QA S+D
Sbjct: 420 ----------KADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQG-SRD 468
Query: 1536 MSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLV 1595
S S+ + + E E T ++ P + GG A +K G A +
Sbjct: 469 SSSDSDSSSSEEEEEKTSKSAVKKK---PQKVAGGAAPSKPASAKKGKAESSNSSSSDDS 525
Query: 1596 EPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEV-----ELQE 1650
+E+EK P Q T A ++ + +++EK+ A V L++
Sbjct: 526 SEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKK 585
Query: 1651 GKVHSESDKAITPQAQE 1667
K + + +A TPQA++
Sbjct: 586 RKQNEAAKEAETPQAKK 602
Score = 34.3 bits (77), Expect = 1.0
Identities = 39/201 (19%), Positives = 78/201 (38%), Gaps = 18/201 (8%)
Query: 1486 KADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMT 1545
KA S D+ ++ E E P+ TP+T + +A I+ + +S + +
Sbjct: 163 KAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSS 222
Query: 1546 VEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEP-KEDEKGD 1604
S+ +D + EE+ K+VP+ ++A+ K+ P ++ +
Sbjct: 223 ---SSSSSDDSE--------EEKAAATPKKTVPKKQ---VVAKAPVKAATTPTRKSSSSE 268
Query: 1605 DVDDPENQNSALADTDASGGLTKESPDTNGPKQKE---KEDAQEVELQEGKVHSESDKAI 1661
D E + + G + P + P +K + + VE Q+ SE
Sbjct: 269 DSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDE 328
Query: 1662 TPQAQEELQKQERESAKSELT 1682
+ + EE +K ++ S+ T
Sbjct: 329 SDSSSEEEKKPPTKAVVSKAT 349
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 73.6 bits (179), Expect = 2e-12
Identities = 228/1214 (18%), Positives = 451/1214 (37%), Gaps = 194/1214 (15%)
Query: 126 EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEE-----KQEKEPS 180
EAA + K+S ++ + L R+ S AEI A +A E + EE + + E +
Sbjct: 1406 EAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 181 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 240
+ + ++ Q + R+ +DE S++K++ E E + +
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVE-LASR 1520
Query: 241 EDGKAEVASEK-----------LTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 289
+AE A EK L A E AE ++ E + +E ++
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Query: 290 SQGPSEEKPAPLATEVFDEKIEVHQ--EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE 347
+ EK A L + +E + V Q EE ER E+ E E + A
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-AERELERWQLKAN 1639
Query: 348 ELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS 407
E + + + +E K L + E Q + + + K E V + E+
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQ-------AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 408 Q---ERMKVQGSPLKKLFTSTGLKKLSGKKQKG--KRGGGDEESGEHTQVPADSPDSQEE 462
+ +R +G+ ++L L +L + ++G +R +EE + A + +Q+
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--TQKR 1750
Query: 463 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG---ATSDGEKKREGVTPWASFKKMV 519
Q+ E+ + E+ K AE + +E+ ++ + RE A + +
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810
Query: 520 TPKKRVRRPSESD---KEDELDKVKSATLSST-ESTASEMQEEMKGSVEEPKPEEPKRKV 575
KR R+ +E D + E ++V + L++ E+T + + E+ +E + E +R
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870
Query: 576 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 635
+ + ++R ++ + + +KA ++ +++ G L
Sbjct: 1871 EDE----------AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG----LVEDT 1916
Query: 636 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 695
Q + E E L R ++ L K + + +
Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 696 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 755
+ E + E+ ++K + + +Q +A +E+
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEA---ARQRKAALEE----------------------- 2010
Query: 756 AVEREKMEAQQAQKSAEQPEQKAATEV-------SKEL-SESQVHMMAAAVADGTRAATI 807
VER K + ++A++ E+ EQ++A ++ K L +E + H A + T+
Sbjct: 2011 -VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 808 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 867
+E+ SV + L + EAEAA E E + E + E E +
Sbjct: 2070 QQEQ-------SVLDQL-RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 868 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 927
+A+ +A AAE +E + AE+ +++
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA---------------------LRQK 2160
Query: 928 EGGVPDIEEQERRTQEVLQAVAEKVKE----ESQLPGTGGPEDVL-QPVQRAEAERPEEQ 982
+ ++E+ ++ ++ L+ A+ +E QL T +++L + +QR +AE E
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2220
Query: 983 AEASGLKKETDVVLKVDAQE-----AKTEPFTQGKVV------GQTTPESFEKAPQVTES 1031
+ S +++E V +V +E A+ E + ++ + E EK QV E
Sbjct: 2221 RQRSQVEEELFSV-RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE- 2278
Query: 1032 IESSEL-VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1090
E++ L V +A L + +++ ++A+ ++ + + T K
Sbjct: 2279 -EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-----------ATRLK 2326
Query: 1091 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE---H 1147
E + ++ E+A +A + KE+ + Q+ +E + TLE
Sbjct: 2327 AEAELLQQQKELAQ------EQARRLQEDKEQ-------MAQQLAEETQGFQRTLEAERQ 2373
Query: 1148 TDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALK 1207
E+S E + + A A+E + R++ E+ K
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----------------RKQAEEIGEK 2416
Query: 1208 GEGTEEAECKK---DDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1264
TE A +K LE+Q + RE + ++EREK + + +L+ E
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ-QEAKLLQLKSEE 2475
Query: 1265 AVTVSEEVSKQLLQ 1278
TV +E QLLQ
Sbjct: 2476 MQTVQQE---QLLQ 2486
Score = 68.6 bits (166), Expect = 5e-11
Identities = 263/1431 (18%), Positives = 535/1431 (37%), Gaps = 181/1431 (12%)
Query: 272 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 331
L+++Y K + ++ + +E++ A + + + + ++ +AE H +
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 332 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 391
E K + V E +DA+ Q+ +EL +L++ S + ++
Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ--------------SSEAEIQ 1434
Query: 392 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 451
+K + +E L +E ++V +L + + +RGG + E + +
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRV--------------VRLQLEATERQRGGAEGEL-QALR 1479
Query: 452 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTP 511
A+ ++Q+ Q E + + ++ K AEV+ + A + EK+R
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQR----A 1534
Query: 512 WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEP 571
+ +++ + R + + +V+ A ++ S +E+Q + E K +
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQL 1592
Query: 572 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 631
+R + E + V ++ A R + E + + K E +
Sbjct: 1593 ERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 632 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 691
A + E+ E E ++ ++ V R+ ++ +LE++ + +
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------L 1700
Query: 692 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 751
T E+ + + R + G+Q++ +E+ E + L
Sbjct: 1701 AEGTAQQRLAAEQELIRL-------RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 752 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER 811
A R +ME A K+ + E ++ +E SK+ E++ + R + EE
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1813
Query: 812 SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA 871
A ++ EAE L + E + T E + +EA + + A
Sbjct: 1814 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK---TEAEIALKEKEAENERLRRLA 1870
Query: 872 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 931
E EA E AA+ ++ ++QL + D + ++ +G V
Sbjct: 1871 E--DEAF----------QRRRLEEQAAQHKADIEERLAQLRKASD-----SELERQKGLV 1913
Query: 932 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGL 988
D Q R+ +E + +A K E G E L + R+ AE R +EQAE
Sbjct: 1914 EDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAA 1970
Query: 989 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTC--QAETL 1046
++ ++ A+E + + +V E E A Q ++E E + +A L
Sbjct: 1971 RQR-----QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRL 2024
Query: 1047 AGVKSQEMVMEQAIPPDSVETPTDSETDG---STPVADFDAPGTTQKDEIVEIHEENEVA 1103
QE + + ++ + +E + + + T Q+++ V + + A
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV-LDQLRGEA 2083
Query: 1104 SGTQSGGTEAEAVPAQKERPPAPSSFVFQE-ETKEQSKMEDTLEHTDKEVSVETVSILSK 1162
+ EAE Q ER A S +E E +QS E + + E + +
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL----R 2139
Query: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1222
E QEA + A + + + + ++ +K E L+ + E E L
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEME-----KHKKFAEQTLRQKAQVEQEL---TTL 2191
Query: 1223 ELQSHAKSPPSPVEREMVVQVEREKTEA--EPTHVNEEKLEHETAVTVSEEVS--KQLLQ 1278
LQ + E + +++ E TEA + + V EE + EE+S K ++
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM---EELSKLKARIE 2248
Query: 1279 TVNVPII----DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE----- 1329
N +I D + E + +E A ++ V + EA+ A E+
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---RLSVAAQEAARLRQLAEEDLAQQR 2305
Query: 1330 ---EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1386
EK+L E ++ L+ A A L+ ++K E ++ A ED K
Sbjct: 2306 ALAEKMLKEKMQAVQEATRLK-AEAELLQQQK--ELAQEQARRLQED----------KEQ 2352
Query: 1387 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1446
A +G LE E+ L+ ++ E++ + ++S A E
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEA--ERLKLRVAEMSRA--QARAEEDAQRFRK 2408
Query: 1447 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADS-QDAGQETEKEGEEPQA 1505
++ ++ + + +T + T+E T + T E+Q Q A+ ++A E E+E E+ Q
Sbjct: 2409 QAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464
Query: 1506 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1565
A K + SE+ TV+ E Q L++ L S
Sbjct: 2465 EA--------------------------KLLQLKSEEMQTVQQEQLLQETQALQQSFL-S 2497
Query: 1566 EEEGGGAGTKSVPEDDG--HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASG 1623
E++ + + ++ L + + K+ +E ++ + E Q +A + +
Sbjct: 2498 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR-LVASMEEAR 2556
Query: 1624 GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQER 1674
E+ + KQ+E + ++ Q+ ++ +E ++ + Q Q L++Q R
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHR 2606
Score = 52.4 bits (124), Expect = 4e-06
Identities = 179/996 (17%), Positives = 359/996 (36%), Gaps = 124/996 (12%)
Query: 733 AGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVH 792
A PT +E + + + + A+ EK++ Q ++ ++L E+Q
Sbjct: 1059 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1118
Query: 793 MMAAAVADGTRAA-----TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE 847
+ T+A+ E + P++ ++ + L + L + ER+V E
Sbjct: 1119 PATLPELEATKASLKKLRAQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVER 1176
Query: 848 EPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEETTEM 904
V + L + T V + EL + E+A PLGA E+ M
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236
Query: 905 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK----VKEESQLPG 960
A SQ E+A ++E+E +EE +R ++ + A+ + V ++QL
Sbjct: 1237 PLADSQAVREQLRQEQAL-LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1293
Query: 961 TGGPEDVLQPVQRAEAERPEEQA--EASGLKKETDVVLKVDAQEAKTEPFT------QGK 1012
E V P ++ + + E E L+ + + +Q K T + +
Sbjct: 1294 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 1013 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1072
+ Q E E+ +V ++E + A+ A + + ++Q + + V
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR----- 1404
Query: 1073 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1132
D + ++E+ ++ + +E Q+ +AEA + R +
Sbjct: 1405 ---EEAAVDAQQQKRSIQEELQQLRQSSEAE--IQAKARQAEAAERSRLR--------IE 1451
Query: 1133 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDT 1192
EE + + E E ++ ++ E + + A E+ E L +
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQVQD 1505
Query: 1193 GITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEP 1252
R+ E+A + + EA +K AL+ R + ER +AE
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--------RLQAEEAERRLRQAEV 1557
Query: 1253 THVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKI 1312
+ ++ ETA +E LQ+ A++ + LE S L +E ++
Sbjct: 1558 ERARQVQVALETAQRSAEAE----LQSKRASF---AEKTAQLERS----LQEEHVAVAQL 1606
Query: 1313 QVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGE 1372
+ EA AE E+ E LE + L L+ + + + A
Sbjct: 1607 R---EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA----- 1658
Query: 1373 DAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI 1432
QA++ A + E + + E+++Q +++ A
Sbjct: 1659 ---------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQ 1706
Query: 1433 EDLEPENGILEL--ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1490
+ L E ++ L ET+ + + +++ + + R AT+ EL+ + ++A+ +
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK-RQELEAELAKVRAEME 1765
Query: 1491 -----DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSE-ASEKTM 1544
A E E ++ + E +E +E A +A ++ +K + A E
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1825
Query: 1545 TVEVEGSTVNDQQL-----------EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1593
E V ++L E + E+E + + ED+ A R+E+
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE--AFQRRRLEEQ 1883
Query: 1594 LVEPKED--------EKGDDVDDPENQNSALADT-DASGGLTKESPDTNGPKQKEKEDAQ 1644
+ K D K D + E Q + DT + +E +K
Sbjct: 1884 AAQHKADIEERLAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 1645 EVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1680
E+EL+ G++ S ++ + + Q EL+ + +E
Sbjct: 1943 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978
Score = 45.4 bits (106), Expect = 5e-04
Identities = 184/981 (18%), Positives = 369/981 (37%), Gaps = 114/981 (11%)
Query: 24 KEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEE-LTQPTESQANDIGFKKVFKFVG 82
KE ++ + + +D + + EQ ++++EE L Q ++ +++ +K G
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----G 1911
Query: 83 FKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGD----------HKDPSLGAGEAASKES 132
+ + + + ++L +K + AAG + + + +L + E A E+
Sbjct: 1912 LVEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969
Query: 133 EPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTS 192
++ EE +RE A +A + K EE E+ +K E+ +
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERA 2028
Query: 193 ETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEED---GKAEVAS 249
E S + Q A ++ + K V+ E++ +Q ++ + D G+AE A
Sbjct: 2029 EQESARQLQLAQE-AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2087
Query: 250 EKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK 309
+E+A Q E+A R E E+++ +EEQ ++ ++ L E E
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-ARAQAQAAAEKLRKEAEQEA 2146
Query: 310 IEVHQEEVVAEVHVSTVEERTEEQKTEVEET--AGSVPAEELVEMDAEPQEAEPAKELVK 367
Q E A + E+ K E+T + +EL + + +E + K L+
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 368 LKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS-QERMKVQGSPL-------- 418
+ + E S E+ L V ++E LS + R++ + L
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELF----SVRVQMEELSKLKARIEAENRALILRDKDNT 2262
Query: 419 KKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEI 478
++ K ++ + +E+ Q+ + Q + + +E
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322
Query: 479 TCLEKGLAEVQQDGE-AEEGATSDGEKKREGVTPWA----SFKKMVTPKKRVRRPSESDK 533
T L+ +QQ E A+E A E K + A F++ + ++ +R E
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--QRQLEMSA 2380
Query: 534 EDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKR 593
E E K++ A +S ++ A E + + EE + + T ++ + + + + +
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR----TELATQEKVTLVQTLEI 2436
Query: 594 ARRGSSSDEEGGPKAMG---GDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAG 650
R+ S D E +A+ + +K + K + ++ + QE + + Q
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE--TQALQQS 2494
Query: 651 SPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK 710
+E + + E F ++ K+KLE+ +D +A + +EE
Sbjct: 2495 FLSEKDSLLQRERF------IEQEKAKLEQLFQDEVA---------KAQQLREEQ----- 2534
Query: 711 KFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKS 770
+R+++ ++ Q V + +++ + V R++ E QQ ++
Sbjct: 2535 -----QRQQQQMEQERQRLVASMEEARRRQHEAE----------EGVRRKQEELQQLEQQ 2579
Query: 771 AEQPEQKAATEVSK-----ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLE 825
Q E+ A E + +L E Q H A A ++ A+ + ++ ++ P
Sbjct: 2580 RRQQEELLAEENQRLREQLQLLEEQ-HRAALAHSEEVTASQVAATKTLPNGRDALDGPAA 2638
Query: 826 QVEAEAALLTEEVLEREVIAEE-EPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETA 884
+ E E + + L R+V A+ + + R A+G T V E + +
Sbjct: 2639 EAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGR 2695
Query: 885 GPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEV 944
+ G A E + +A+ + SP T Q G + D R T
Sbjct: 2696 SSIA---GLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLT--- 2749
Query: 945 LQAVAEKVKEESQLPGTGGPE 965
V E VKE G GPE
Sbjct: 2750 ---VNEAVKE-----GVVGPE 2762
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 73.6 bits (179), Expect = 2e-12
Identities = 228/1214 (18%), Positives = 451/1214 (37%), Gaps = 194/1214 (15%)
Query: 126 EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEE-----KQEKEPS 180
EAA + K+S ++ + L R+ S AEI A +A E + EE + + E +
Sbjct: 1410 EAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1468
Query: 181 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 240
+ + ++ Q + R+ +DE S++K++ E E + +
Sbjct: 1469 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVE-LASR 1524
Query: 241 EDGKAEVASEK-----------LTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 289
+AE A EK L A E AE ++ E + +E ++
Sbjct: 1525 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1584
Query: 290 SQGPSEEKPAPLATEVFDEKIEVHQ--EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE 347
+ EK A L + +E + V Q EE ER E+ E E + A
Sbjct: 1585 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-AERELERWQLKAN 1643
Query: 348 ELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS 407
E + + + +E K L + E Q + + + K E V + E+
Sbjct: 1644 EALRLRLQAEEVAQQKSLAQ-------AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696
Query: 408 Q---ERMKVQGSPLKKLFTSTGLKKLSGKKQKG--KRGGGDEESGEHTQVPADSPDSQEE 462
+ +R +G+ ++L L +L + ++G +R +EE + A + +Q+
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--TQKR 1754
Query: 463 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG---ATSDGEKKREGVTPWASFKKMV 519
Q+ E+ + E+ K AE + +E+ ++ + RE A + +
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1814
Query: 520 TPKKRVRRPSESD---KEDELDKVKSATLSST-ESTASEMQEEMKGSVEEPKPEEPKRKV 575
KR R+ +E D + E ++V + L++ E+T + + E+ +E + E +R
Sbjct: 1815 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1874
Query: 576 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 635
+ + ++R ++ + + +KA ++ +++ G L
Sbjct: 1875 EDE----------AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG----LVEDT 1920
Query: 636 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 695
Q + E E L R ++ L K + + +
Sbjct: 1921 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1980
Query: 696 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 755
+ E + E+ ++K + + +Q +A +E+
Sbjct: 1981 AEEERRRREAEERVQKSLAAEEEA---ARQRKAALEE----------------------- 2014
Query: 756 AVEREKMEAQQAQKSAEQPEQKAATEV-------SKEL-SESQVHMMAAAVADGTRAATI 807
VER K + ++A++ E+ EQ++A ++ K L +E + H A + T+
Sbjct: 2015 -VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2073
Query: 808 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 867
+E+ SV + L + EAEAA E E + E + E E +
Sbjct: 2074 QQEQ-------SVLDQL-RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2125
Query: 868 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 927
+A+ +A AAE +E + AE+ +++
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA---------------------LRQK 2164
Query: 928 EGGVPDIEEQERRTQEVLQAVAEKVKE----ESQLPGTGGPEDVL-QPVQRAEAERPEEQ 982
+ ++E+ ++ ++ L+ A+ +E QL T +++L + +QR +AE E
Sbjct: 2165 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2224
Query: 983 AEASGLKKETDVVLKVDAQE-----AKTEPFTQGKVV------GQTTPESFEKAPQVTES 1031
+ S +++E V +V +E A+ E + ++ + E EK QV E
Sbjct: 2225 RQRSQVEEELFSV-RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE- 2282
Query: 1032 IESSEL-VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1090
E++ L V +A L + +++ ++A+ ++ + + T K
Sbjct: 2283 -EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-----------ATRLK 2330
Query: 1091 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE---H 1147
E + ++ E+A +A + KE+ + Q+ +E + TLE
Sbjct: 2331 AEAELLQQQKELAQ------EQARRLQEDKEQ-------MAQQLAEETQGFQRTLEAERQ 2377
Query: 1148 TDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALK 1207
E+S E + + A A+E + R++ E+ K
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----------------RKQAEEIGEK 2420
Query: 1208 GEGTEEAECKK---DDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1264
TE A +K LE+Q + RE + ++EREK + + +L+ E
Sbjct: 2421 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ-QEAKLLQLKSEE 2479
Query: 1265 AVTVSEEVSKQLLQ 1278
TV +E QLLQ
Sbjct: 2480 MQTVQQE---QLLQ 2490
Score = 68.6 bits (166), Expect = 5e-11
Identities = 263/1431 (18%), Positives = 535/1431 (37%), Gaps = 181/1431 (12%)
Query: 272 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 331
L+++Y K + ++ + +E++ A + + + + ++ +AE H +
Sbjct: 1333 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1392
Query: 332 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 391
E K + V E +DA+ Q+ +EL +L++ S + ++
Sbjct: 1393 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ--------------SSEAEIQ 1438
Query: 392 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 451
+K + +E L +E ++V +L + + +RGG + E + +
Sbjct: 1439 AKARQAEAAERSRLRIEEEIRV--------------VRLQLEATERQRGGAEGEL-QALR 1483
Query: 452 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTP 511
A+ ++Q+ Q E + + ++ K AEV+ + A + EK+R
Sbjct: 1484 ARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQR----A 1538
Query: 512 WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEP 571
+ +++ + R + + +V+ A ++ S +E+Q + E K +
Sbjct: 1539 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQL 1596
Query: 572 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 631
+R + E + V ++ A R + E + + K E +
Sbjct: 1597 ERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1651
Query: 632 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 691
A + E+ E E ++ ++ V R+ ++ +LE++ + +
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------L 1704
Query: 692 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 751
T E+ + + R + G+Q++ +E+ E + L
Sbjct: 1705 AEGTAQQRLAAEQELIRL-------RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757
Query: 752 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER 811
A R +ME A K+ + E ++ +E SK+ E++ + R + EE
Sbjct: 1758 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1817
Query: 812 SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA 871
A ++ EAE L + E + T E + +EA + + A
Sbjct: 1818 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK---TEAEIALKEKEAENERLRRLA 1874
Query: 872 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 931
E EA E AA+ ++ ++QL + D + ++ +G V
Sbjct: 1875 E--DEAF----------QRRRLEEQAAQHKADIEERLAQLRKASD-----SELERQKGLV 1917
Query: 932 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGL 988
D Q R+ +E + +A K E G E L + R+ AE R +EQAE
Sbjct: 1918 EDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAA 1974
Query: 989 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTC--QAETL 1046
++ ++ A+E + + +V E E A Q ++E E + +A L
Sbjct: 1975 RQR-----QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRL 2028
Query: 1047 AGVKSQEMVMEQAIPPDSVETPTDSETDG---STPVADFDAPGTTQKDEIVEIHEENEVA 1103
QE + + ++ + +E + + + T Q+++ V + + A
Sbjct: 2029 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV-LDQLRGEA 2087
Query: 1104 SGTQSGGTEAEAVPAQKERPPAPSSFVFQE-ETKEQSKMEDTLEHTDKEVSVETVSILSK 1162
+ EAE Q ER A S +E E +QS E + + E + +
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL----R 2143
Query: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1222
E QEA + A + + + + ++ +K E L+ + E E L
Sbjct: 2144 KEAEQEAARRAQAEQAALRQKQAADAEME-----KHKKFAEQTLRQKAQVEQEL---TTL 2195
Query: 1223 ELQSHAKSPPSPVEREMVVQVEREKTEA--EPTHVNEEKLEHETAVTVSEEVS--KQLLQ 1278
LQ + E + +++ E TEA + + V EE + EE+S K ++
Sbjct: 2196 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM---EELSKLKARIE 2252
Query: 1279 TVNVPII----DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE----- 1329
N +I D + E + +E A ++ V + EA+ A E+
Sbjct: 2253 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---RLSVAAQEAARLRQLAEEDLAQQR 2309
Query: 1330 ---EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1386
EK+L E ++ L+ A A L+ ++K E ++ A ED K
Sbjct: 2310 ALAEKMLKEKMQAVQEATRLK-AEAELLQQQK--ELAQEQARRLQED----------KEQ 2356
Query: 1387 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1446
A +G LE E+ L+ ++ E++ + ++S A E
Sbjct: 2357 MAQQLAEETQGFQRTLEAERQRQLEMSAEA--ERLKLRVAEMSRA--QARAEEDAQRFRK 2412
Query: 1447 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADS-QDAGQETEKEGEEPQA 1505
++ ++ + + +T + T+E T + T E+Q Q A+ ++A E E+E E+ Q
Sbjct: 2413 QAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2468
Query: 1506 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1565
A K + SE+ TV+ E Q L++ L S
Sbjct: 2469 EA--------------------------KLLQLKSEEMQTVQQEQLLQETQALQQSFL-S 2501
Query: 1566 EEEGGGAGTKSVPEDDG--HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASG 1623
E++ + + ++ L + + K+ +E ++ + E Q +A + +
Sbjct: 2502 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR-LVASMEEAR 2560
Query: 1624 GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQER 1674
E+ + KQ+E + ++ Q+ ++ +E ++ + Q Q L++Q R
Sbjct: 2561 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHR 2610
Score = 52.4 bits (124), Expect = 4e-06
Identities = 179/996 (17%), Positives = 359/996 (36%), Gaps = 124/996 (12%)
Query: 733 AGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVH 792
A PT +E + + + + A+ EK++ Q ++ ++L E+Q
Sbjct: 1063 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1122
Query: 793 MMAAAVADGTRAA-----TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE 847
+ T+A+ E + P++ ++ + L + L + ER+V E
Sbjct: 1123 PATLPELEATKASLKKLRAQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVER 1180
Query: 848 EPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEETTEM 904
V + L + T V + EL + E+A PLGA E+ M
Sbjct: 1181 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1240
Query: 905 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK----VKEESQLPG 960
A SQ E+A ++E+E +EE +R ++ + A+ + V ++QL
Sbjct: 1241 PLADSQAVREQLRQEQAL-LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1297
Query: 961 TGGPEDVLQPVQRAEAERPEEQA--EASGLKKETDVVLKVDAQEAKTEPFT------QGK 1012
E V P ++ + + E E L+ + + +Q K T + +
Sbjct: 1298 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1353
Query: 1013 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1072
+ Q E E+ +V ++E + A+ A + + ++Q + + V
Sbjct: 1354 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR----- 1408
Query: 1073 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1132
D + ++E+ ++ + +E Q+ +AEA + R +
Sbjct: 1409 ---EEAAVDAQQQKRSIQEELQQLRQSSEAE--IQAKARQAEAAERSRLR--------IE 1455
Query: 1133 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDT 1192
EE + + E E ++ ++ E + + A E+ E L +
Sbjct: 1456 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQVQD 1509
Query: 1193 GITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEP 1252
R+ E+A + + EA +K AL+ R + ER +AE
Sbjct: 1510 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--------RLQAEEAERRLRQAEV 1561
Query: 1253 THVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKI 1312
+ ++ ETA +E LQ+ A++ + LE S L +E ++
Sbjct: 1562 ERARQVQVALETAQRSAEAE----LQSKRASF---AEKTAQLERS----LQEEHVAVAQL 1610
Query: 1313 QVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGE 1372
+ EA AE E+ E LE + L L+ + + + A
Sbjct: 1611 R---EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA----- 1662
Query: 1373 DAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI 1432
QA++ A + E + + E+++Q +++ A
Sbjct: 1663 ---------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQ 1710
Query: 1433 EDLEPENGILEL--ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1490
+ L E ++ L ET+ + + +++ + + R AT+ EL+ + ++A+ +
Sbjct: 1711 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK-RQELEAELAKVRAEME 1769
Query: 1491 -----DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSE-ASEKTM 1544
A E E ++ + E +E +E A +A ++ +K + A E
Sbjct: 1770 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1829
Query: 1545 TVEVEGSTVNDQQL-----------EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1593
E V ++L E + E+E + + ED+ A R+E+
Sbjct: 1830 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE--AFQRRRLEEQ 1887
Query: 1594 LVEPKED--------EKGDDVDDPENQNSALADT-DASGGLTKESPDTNGPKQKEKEDAQ 1644
+ K D K D + E Q + DT + +E +K
Sbjct: 1888 AAQHKADIEERLAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946
Query: 1645 EVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1680
E+EL+ G++ S ++ + + Q EL+ + +E
Sbjct: 1947 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1982
Score = 45.4 bits (106), Expect = 5e-04
Identities = 184/981 (18%), Positives = 369/981 (37%), Gaps = 114/981 (11%)
Query: 24 KEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEE-LTQPTESQANDIGFKKVFKFVG 82
KE ++ + + +D + + EQ ++++EE L Q ++ +++ +K G
Sbjct: 1861 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----G 1915
Query: 83 FKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGD----------HKDPSLGAGEAASKES 132
+ + + + ++L +K + AAG + + + +L + E A E+
Sbjct: 1916 LVEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1973
Query: 133 EPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTS 192
++ EE +RE A +A + K EE E+ +K E+ +
Sbjct: 1974 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERA 2032
Query: 193 ETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEED---GKAEVAS 249
E S + Q A ++ + K V+ E++ +Q ++ + D G+AE A
Sbjct: 2033 EQESARQLQLAQE-AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2091
Query: 250 EKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK 309
+E+A Q E+A R E E+++ +EEQ ++ ++ L E E
Sbjct: 2092 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-ARAQAQAAAEKLRKEAEQEA 2150
Query: 310 IEVHQEEVVAEVHVSTVEERTEEQKTEVEET--AGSVPAEELVEMDAEPQEAEPAKELVK 367
Q E A + E+ K E+T + +EL + + +E + K L+
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2210
Query: 368 LKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS-QERMKVQGSPL-------- 418
+ + E S E+ L V ++E LS + R++ + L
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELF----SVRVQMEELSKLKARIEAENRALILRDKDNT 2266
Query: 419 KKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEI 478
++ K ++ + +E+ Q+ + Q + + +E
Sbjct: 2267 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2326
Query: 479 TCLEKGLAEVQQDGE-AEEGATSDGEKKREGVTPWA----SFKKMVTPKKRVRRPSESDK 533
T L+ +QQ E A+E A E K + A F++ + ++ +R E
Sbjct: 2327 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--QRQLEMSA 2384
Query: 534 EDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKR 593
E E K++ A +S ++ A E + + EE + + T ++ + + + + +
Sbjct: 2385 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR----TELATQEKVTLVQTLEI 2440
Query: 594 ARRGSSSDEEGGPKAMG---GDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAG 650
R+ S D E +A+ + +K + K + ++ + QE + + Q
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE--TQALQQS 2498
Query: 651 SPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK 710
+E + + E F ++ K+KLE+ +D +A + +EE
Sbjct: 2499 FLSEKDSLLQRERF------IEQEKAKLEQLFQDEVA---------KAQQLREEQ----- 2538
Query: 711 KFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKS 770
+R+++ ++ Q V + +++ + V R++ E QQ ++
Sbjct: 2539 -----QRQQQQMEQERQRLVASMEEARRRQHEAE----------EGVRRKQEELQQLEQQ 2583
Query: 771 AEQPEQKAATEVSK-----ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLE 825
Q E+ A E + +L E Q H A A ++ A+ + ++ ++ P
Sbjct: 2584 RRQQEELLAEENQRLREQLQLLEEQ-HRAALAHSEEVTASQVAATKTLPNGRDALDGPAA 2642
Query: 826 QVEAEAALLTEEVLEREVIAEE-EPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETA 884
+ E E + + L R+V A+ + + R A+G T V E + +
Sbjct: 2643 EAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGR 2699
Query: 885 GPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEV 944
+ G A E + +A+ + SP T Q G + D R T
Sbjct: 2700 SSIA---GLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLT--- 2753
Query: 945 LQAVAEKVKEESQLPGTGGPE 965
V E VKE G GPE
Sbjct: 2754 ---VNEAVKE-----GVVGPE 2766
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 73.6 bits (179), Expect = 2e-12
Identities = 228/1214 (18%), Positives = 451/1214 (37%), Gaps = 194/1214 (15%)
Query: 126 EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEE-----KQEKEPS 180
EAA + K+S ++ + L R+ S AEI A +A E + EE + + E +
Sbjct: 1406 EAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 181 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 240
+ + ++ Q + R+ +DE S++K++ E E + +
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVE-LASR 1520
Query: 241 EDGKAEVASEK-----------LTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 289
+AE A EK L A E AE ++ E + +E ++
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Query: 290 SQGPSEEKPAPLATEVFDEKIEVHQ--EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE 347
+ EK A L + +E + V Q EE ER E+ E E + A
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-AERELERWQLKAN 1639
Query: 348 ELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS 407
E + + + +E K L + E Q + + + K E V + E+
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQ-------AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 408 Q---ERMKVQGSPLKKLFTSTGLKKLSGKKQKG--KRGGGDEESGEHTQVPADSPDSQEE 462
+ +R +G+ ++L L +L + ++G +R +EE + A + +Q+
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--TQKR 1750
Query: 463 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG---ATSDGEKKREGVTPWASFKKMV 519
Q+ E+ + E+ K AE + +E+ ++ + RE A + +
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810
Query: 520 TPKKRVRRPSESD---KEDELDKVKSATLSST-ESTASEMQEEMKGSVEEPKPEEPKRKV 575
KR R+ +E D + E ++V + L++ E+T + + E+ +E + E +R
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870
Query: 576 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 635
+ + ++R ++ + + +KA ++ +++ G L
Sbjct: 1871 EDE----------AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG----LVEDT 1916
Query: 636 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 695
Q + E E L R ++ L K + + +
Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 696 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 755
+ E + E+ ++K + + +Q +A +E+
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEA---ARQRKAALEE----------------------- 2010
Query: 756 AVEREKMEAQQAQKSAEQPEQKAATEV-------SKEL-SESQVHMMAAAVADGTRAATI 807
VER K + ++A++ E+ EQ++A ++ K L +E + H A + T+
Sbjct: 2011 -VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 808 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 867
+E+ SV + L + EAEAA E E + E + E E +
Sbjct: 2070 QQEQ-------SVLDQL-RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 868 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 927
+A+ +A AAE +E + AE+ +++
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA---------------------LRQK 2160
Query: 928 EGGVPDIEEQERRTQEVLQAVAEKVKE----ESQLPGTGGPEDVL-QPVQRAEAERPEEQ 982
+ ++E+ ++ ++ L+ A+ +E QL T +++L + +QR +AE E
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2220
Query: 983 AEASGLKKETDVVLKVDAQE-----AKTEPFTQGKVV------GQTTPESFEKAPQVTES 1031
+ S +++E V +V +E A+ E + ++ + E EK QV E
Sbjct: 2221 RQRSQVEEELFSV-RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE- 2278
Query: 1032 IESSEL-VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1090
E++ L V +A L + +++ ++A+ ++ + + T K
Sbjct: 2279 -EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-----------ATRLK 2326
Query: 1091 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE---H 1147
E + ++ E+A +A + KE+ + Q+ +E + TLE
Sbjct: 2327 AEAELLQQQKELAQ------EQARRLQEDKEQ-------MAQQLAEETQGFQRTLEAERQ 2373
Query: 1148 TDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALK 1207
E+S E + + A A+E + R++ E+ K
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----------------RKQAEEIGEK 2416
Query: 1208 GEGTEEAECKK---DDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1264
TE A +K LE+Q + RE + ++EREK + + +L+ E
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ-QEAKLLQLKSEE 2475
Query: 1265 AVTVSEEVSKQLLQ 1278
TV +E QLLQ
Sbjct: 2476 MQTVQQE---QLLQ 2486
Score = 68.6 bits (166), Expect = 5e-11
Identities = 263/1431 (18%), Positives = 535/1431 (37%), Gaps = 181/1431 (12%)
Query: 272 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 331
L+++Y K + ++ + +E++ A + + + + ++ +AE H +
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 332 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 391
E K + V E +DA+ Q+ +EL +L++ S + ++
Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ--------------SSEAEIQ 1434
Query: 392 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 451
+K + +E L +E ++V +L + + +RGG + E + +
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRV--------------VRLQLEATERQRGGAEGEL-QALR 1479
Query: 452 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTP 511
A+ ++Q+ Q E + + ++ K AEV+ + A + EK+R
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQR----A 1534
Query: 512 WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEP 571
+ +++ + R + + +V+ A ++ S +E+Q + E K +
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQL 1592
Query: 572 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 631
+R + E + V ++ A R + E + + K E +
Sbjct: 1593 ERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 632 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 691
A + E+ E E ++ ++ V R+ ++ +LE++ + +
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------L 1700
Query: 692 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 751
T E+ + + R + G+Q++ +E+ E + L
Sbjct: 1701 AEGTAQQRLAAEQELIRL-------RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 752 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER 811
A R +ME A K+ + E ++ +E SK+ E++ + R + EE
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1813
Query: 812 SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA 871
A ++ EAE L + E + T E + +EA + + A
Sbjct: 1814 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK---TEAEIALKEKEAENERLRRLA 1870
Query: 872 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 931
E EA E AA+ ++ ++QL + D + ++ +G V
Sbjct: 1871 E--DEAF----------QRRRLEEQAAQHKADIEERLAQLRKASD-----SELERQKGLV 1913
Query: 932 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGL 988
D Q R+ +E + +A K E G E L + R+ AE R +EQAE
Sbjct: 1914 EDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAA 1970
Query: 989 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTC--QAETL 1046
++ ++ A+E + + +V E E A Q ++E E + +A L
Sbjct: 1971 RQR-----QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRL 2024
Query: 1047 AGVKSQEMVMEQAIPPDSVETPTDSETDG---STPVADFDAPGTTQKDEIVEIHEENEVA 1103
QE + + ++ + +E + + + T Q+++ V + + A
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV-LDQLRGEA 2083
Query: 1104 SGTQSGGTEAEAVPAQKERPPAPSSFVFQE-ETKEQSKMEDTLEHTDKEVSVETVSILSK 1162
+ EAE Q ER A S +E E +QS E + + E + +
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL----R 2139
Query: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1222
E QEA + A + + + + ++ +K E L+ + E E L
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEME-----KHKKFAEQTLRQKAQVEQEL---TTL 2191
Query: 1223 ELQSHAKSPPSPVEREMVVQVEREKTEA--EPTHVNEEKLEHETAVTVSEEVS--KQLLQ 1278
LQ + E + +++ E TEA + + V EE + EE+S K ++
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM---EELSKLKARIE 2248
Query: 1279 TVNVPII----DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE----- 1329
N +I D + E + +E A ++ V + EA+ A E+
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---RLSVAAQEAARLRQLAEEDLAQQR 2305
Query: 1330 ---EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1386
EK+L E ++ L+ A A L+ ++K E ++ A ED K
Sbjct: 2306 ALAEKMLKEKMQAVQEATRLK-AEAELLQQQK--ELAQEQARRLQED----------KEQ 2352
Query: 1387 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1446
A +G LE E+ L+ ++ E++ + ++S A E
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEA--ERLKLRVAEMSRA--QARAEEDAQRFRK 2408
Query: 1447 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADS-QDAGQETEKEGEEPQA 1505
++ ++ + + +T + T+E T + T E+Q Q A+ ++A E E+E E+ Q
Sbjct: 2409 QAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464
Query: 1506 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1565
A K + SE+ TV+ E Q L++ L S
Sbjct: 2465 EA--------------------------KLLQLKSEEMQTVQQEQLLQETQALQQSFL-S 2497
Query: 1566 EEEGGGAGTKSVPEDDG--HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASG 1623
E++ + + ++ L + + K+ +E ++ + E Q +A + +
Sbjct: 2498 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR-LVASMEEAR 2556
Query: 1624 GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQER 1674
E+ + KQ+E + ++ Q+ ++ +E ++ + Q Q L++Q R
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHR 2606
Score = 52.4 bits (124), Expect = 4e-06
Identities = 179/996 (17%), Positives = 359/996 (36%), Gaps = 124/996 (12%)
Query: 733 AGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVH 792
A PT +E + + + + A+ EK++ Q ++ ++L E+Q
Sbjct: 1059 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1118
Query: 793 MMAAAVADGTRAA-----TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE 847
+ T+A+ E + P++ ++ + L + L + ER+V E
Sbjct: 1119 PATLPELEATKASLKKLRAQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVER 1176
Query: 848 EPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEETTEM 904
V + L + T V + EL + E+A PLGA E+ M
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236
Query: 905 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK----VKEESQLPG 960
A SQ E+A ++E+E +EE +R ++ + A+ + V ++QL
Sbjct: 1237 PLADSQAVREQLRQEQAL-LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1293
Query: 961 TGGPEDVLQPVQRAEAERPEEQA--EASGLKKETDVVLKVDAQEAKTEPFT------QGK 1012
E V P ++ + + E E L+ + + +Q K T + +
Sbjct: 1294 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 1013 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1072
+ Q E E+ +V ++E + A+ A + + ++Q + + V
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR----- 1404
Query: 1073 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1132
D + ++E+ ++ + +E Q+ +AEA + R +
Sbjct: 1405 ---EEAAVDAQQQKRSIQEELQQLRQSSEAE--IQAKARQAEAAERSRLR--------IE 1451
Query: 1133 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDT 1192
EE + + E E ++ ++ E + + A E+ E L +
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQVQD 1505
Query: 1193 GITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEP 1252
R+ E+A + + EA +K AL+ R + ER +AE
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--------RLQAEEAERRLRQAEV 1557
Query: 1253 THVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKI 1312
+ ++ ETA +E LQ+ A++ + LE S L +E ++
Sbjct: 1558 ERARQVQVALETAQRSAEAE----LQSKRASF---AEKTAQLERS----LQEEHVAVAQL 1606
Query: 1313 QVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGE 1372
+ EA AE E+ E LE + L L+ + + + A
Sbjct: 1607 R---EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA----- 1658
Query: 1373 DAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI 1432
QA++ A + E + + E+++Q +++ A
Sbjct: 1659 ---------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQ 1706
Query: 1433 EDLEPENGILEL--ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1490
+ L E ++ L ET+ + + +++ + + R AT+ EL+ + ++A+ +
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK-RQELEAELAKVRAEME 1765
Query: 1491 -----DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSE-ASEKTM 1544
A E E ++ + E +E +E A +A ++ +K + A E
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1825
Query: 1545 TVEVEGSTVNDQQL-----------EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1593
E V ++L E + E+E + + ED+ A R+E+
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE--AFQRRRLEEQ 1883
Query: 1594 LVEPKED--------EKGDDVDDPENQNSALADT-DASGGLTKESPDTNGPKQKEKEDAQ 1644
+ K D K D + E Q + DT + +E +K
Sbjct: 1884 AAQHKADIEERLAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 1645 EVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1680
E+EL+ G++ S ++ + + Q EL+ + +E
Sbjct: 1943 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978
Score = 45.4 bits (106), Expect = 5e-04
Identities = 184/981 (18%), Positives = 369/981 (37%), Gaps = 114/981 (11%)
Query: 24 KEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEE-LTQPTESQANDIGFKKVFKFVG 82
KE ++ + + +D + + EQ ++++EE L Q ++ +++ +K G
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----G 1911
Query: 83 FKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGD----------HKDPSLGAGEAASKES 132
+ + + + ++L +K + AAG + + + +L + E A E+
Sbjct: 1912 LVEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969
Query: 133 EPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTS 192
++ EE +RE A +A + K EE E+ +K E+ +
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERA 2028
Query: 193 ETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEED---GKAEVAS 249
E S + Q A ++ + K V+ E++ +Q ++ + D G+AE A
Sbjct: 2029 EQESARQLQLAQE-AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2087
Query: 250 EKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK 309
+E+A Q E+A R E E+++ +EEQ ++ ++ L E E
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-ARAQAQAAAEKLRKEAEQEA 2146
Query: 310 IEVHQEEVVAEVHVSTVEERTEEQKTEVEET--AGSVPAEELVEMDAEPQEAEPAKELVK 367
Q E A + E+ K E+T + +EL + + +E + K L+
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 368 LKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS-QERMKVQGSPL-------- 418
+ + E S E+ L V ++E LS + R++ + L
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELF----SVRVQMEELSKLKARIEAENRALILRDKDNT 2262
Query: 419 KKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEI 478
++ K ++ + +E+ Q+ + Q + + +E
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322
Query: 479 TCLEKGLAEVQQDGE-AEEGATSDGEKKREGVTPWA----SFKKMVTPKKRVRRPSESDK 533
T L+ +QQ E A+E A E K + A F++ + ++ +R E
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--QRQLEMSA 2380
Query: 534 EDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKR 593
E E K++ A +S ++ A E + + EE + + T ++ + + + + +
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR----TELATQEKVTLVQTLEI 2436
Query: 594 ARRGSSSDEEGGPKAMG---GDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAG 650
R+ S D E +A+ + +K + K + ++ + QE + + Q
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE--TQALQQS 2494
Query: 651 SPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK 710
+E + + E F ++ K+KLE+ +D +A + +EE
Sbjct: 2495 FLSEKDSLLQRERF------IEQEKAKLEQLFQDEVA---------KAQQLREEQ----- 2534
Query: 711 KFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKS 770
+R+++ ++ Q V + +++ + V R++ E QQ ++
Sbjct: 2535 -----QRQQQQMEQERQRLVASMEEARRRQHEAE----------EGVRRKQEELQQLEQQ 2579
Query: 771 AEQPEQKAATEVSK-----ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLE 825
Q E+ A E + +L E Q H A A ++ A+ + ++ ++ P
Sbjct: 2580 RRQQEELLAEENQRLREQLQLLEEQ-HRAALAHSEEVTASQVAATKTLPNGRDALDGPAA 2638
Query: 826 QVEAEAALLTEEVLEREVIAEE-EPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETA 884
+ E E + + L R+V A+ + + R A+G T V E + +
Sbjct: 2639 EAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGR 2695
Query: 885 GPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEV 944
+ G A E + +A+ + SP T Q G + D R T
Sbjct: 2696 SSIA---GLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLT--- 2749
Query: 945 LQAVAEKVKEESQLPGTGGPE 965
V E VKE G GPE
Sbjct: 2750 ---VNEAVKE-----GVVGPE 2762
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 73.6 bits (179), Expect = 2e-12
Identities = 228/1214 (18%), Positives = 451/1214 (37%), Gaps = 194/1214 (15%)
Query: 126 EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEE-----KQEKEPS 180
EAA + K+S ++ + L R+ S AEI A +A E + EE + + E +
Sbjct: 1374 EAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1432
Query: 181 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 240
+ + ++ Q + R+ +DE S++K++ E E + +
Sbjct: 1433 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVE-LASR 1488
Query: 241 EDGKAEVASEK-----------LTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 289
+AE A EK L A E AE ++ E + +E ++
Sbjct: 1489 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1548
Query: 290 SQGPSEEKPAPLATEVFDEKIEVHQ--EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE 347
+ EK A L + +E + V Q EE ER E+ E E + A
Sbjct: 1549 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-AERELERWQLKAN 1607
Query: 348 ELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS 407
E + + + +E K L + E Q + + + K E V + E+
Sbjct: 1608 EALRLRLQAEEVAQQKSLAQ-------AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660
Query: 408 Q---ERMKVQGSPLKKLFTSTGLKKLSGKKQKG--KRGGGDEESGEHTQVPADSPDSQEE 462
+ +R +G+ ++L L +L + ++G +R +EE + A + +Q+
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--TQKR 1718
Query: 463 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG---ATSDGEKKREGVTPWASFKKMV 519
Q+ E+ + E+ K AE + +E+ ++ + RE A + +
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1778
Query: 520 TPKKRVRRPSESD---KEDELDKVKSATLSST-ESTASEMQEEMKGSVEEPKPEEPKRKV 575
KR R+ +E D + E ++V + L++ E+T + + E+ +E + E +R
Sbjct: 1779 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1838
Query: 576 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 635
+ + ++R ++ + + +KA ++ +++ G L
Sbjct: 1839 EDE----------AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG----LVEDT 1884
Query: 636 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 695
Q + E E L R ++ L K + + +
Sbjct: 1885 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1944
Query: 696 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 755
+ E + E+ ++K + + +Q +A +E+
Sbjct: 1945 AEEERRRREAEERVQKSLAAEEEA---ARQRKAALEE----------------------- 1978
Query: 756 AVEREKMEAQQAQKSAEQPEQKAATEV-------SKEL-SESQVHMMAAAVADGTRAATI 807
VER K + ++A++ E+ EQ++A ++ K L +E + H A + T+
Sbjct: 1979 -VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2037
Query: 808 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 867
+E+ SV + L + EAEAA E E + E + E E +
Sbjct: 2038 QQEQ-------SVLDQL-RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2089
Query: 868 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 927
+A+ +A AAE +E + AE+ +++
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA---------------------LRQK 2128
Query: 928 EGGVPDIEEQERRTQEVLQAVAEKVKE----ESQLPGTGGPEDVL-QPVQRAEAERPEEQ 982
+ ++E+ ++ ++ L+ A+ +E QL T +++L + +QR +AE E
Sbjct: 2129 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2188
Query: 983 AEASGLKKETDVVLKVDAQE-----AKTEPFTQGKVV------GQTTPESFEKAPQVTES 1031
+ S +++E V +V +E A+ E + ++ + E EK QV E
Sbjct: 2189 RQRSQVEEELFSV-RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE- 2246
Query: 1032 IESSEL-VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1090
E++ L V +A L + +++ ++A+ ++ + + T K
Sbjct: 2247 -EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-----------ATRLK 2294
Query: 1091 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE---H 1147
E + ++ E+A +A + KE+ + Q+ +E + TLE
Sbjct: 2295 AEAELLQQQKELAQ------EQARRLQEDKEQ-------MAQQLAEETQGFQRTLEAERQ 2341
Query: 1148 TDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALK 1207
E+S E + + A A+E + R++ E+ K
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----------------RKQAEEIGEK 2384
Query: 1208 GEGTEEAECKK---DDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1264
TE A +K LE+Q + RE + ++EREK + + +L+ E
Sbjct: 2385 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ-QEAKLLQLKSEE 2443
Query: 1265 AVTVSEEVSKQLLQ 1278
TV +E QLLQ
Sbjct: 2444 MQTVQQE---QLLQ 2454
Score = 68.6 bits (166), Expect = 5e-11
Identities = 263/1431 (18%), Positives = 535/1431 (37%), Gaps = 181/1431 (12%)
Query: 272 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 331
L+++Y K + ++ + +E++ A + + + + ++ +AE H +
Sbjct: 1297 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1356
Query: 332 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 391
E K + V E +DA+ Q+ +EL +L++ S + ++
Sbjct: 1357 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ--------------SSEAEIQ 1402
Query: 392 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 451
+K + +E L +E ++V +L + + +RGG + E + +
Sbjct: 1403 AKARQAEAAERSRLRIEEEIRV--------------VRLQLEATERQRGGAEGEL-QALR 1447
Query: 452 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTP 511
A+ ++Q+ Q E + + ++ K AEV+ + A + EK+R
Sbjct: 1448 ARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQR----A 1502
Query: 512 WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEP 571
+ +++ + R + + +V+ A ++ S +E+Q + E K +
Sbjct: 1503 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQL 1560
Query: 572 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 631
+R + E + V ++ A R + E + + K E +
Sbjct: 1561 ERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1615
Query: 632 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 691
A + E+ E E ++ ++ V R+ ++ +LE++ + +
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------L 1668
Query: 692 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 751
T E+ + + R + G+Q++ +E+ E + L
Sbjct: 1669 AEGTAQQRLAAEQELIRL-------RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721
Query: 752 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER 811
A R +ME A K+ + E ++ +E SK+ E++ + R + EE
Sbjct: 1722 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1781
Query: 812 SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA 871
A ++ EAE L + E + T E + +EA + + A
Sbjct: 1782 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK---TEAEIALKEKEAENERLRRLA 1838
Query: 872 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 931
E EA E AA+ ++ ++QL + D + ++ +G V
Sbjct: 1839 E--DEAF----------QRRRLEEQAAQHKADIEERLAQLRKASD-----SELERQKGLV 1881
Query: 932 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGL 988
D Q R+ +E + +A K E G E L + R+ AE R +EQAE
Sbjct: 1882 EDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAA 1938
Query: 989 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTC--QAETL 1046
++ ++ A+E + + +V E E A Q ++E E + +A L
Sbjct: 1939 RQR-----QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRL 1992
Query: 1047 AGVKSQEMVMEQAIPPDSVETPTDSETDG---STPVADFDAPGTTQKDEIVEIHEENEVA 1103
QE + + ++ + +E + + + T Q+++ V + + A
Sbjct: 1993 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV-LDQLRGEA 2051
Query: 1104 SGTQSGGTEAEAVPAQKERPPAPSSFVFQE-ETKEQSKMEDTLEHTDKEVSVETVSILSK 1162
+ EAE Q ER A S +E E +QS E + + E + +
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL----R 2107
Query: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1222
E QEA + A + + + + ++ +K E L+ + E E L
Sbjct: 2108 KEAEQEAARRAQAEQAALRQKQAADAEME-----KHKKFAEQTLRQKAQVEQEL---TTL 2159
Query: 1223 ELQSHAKSPPSPVEREMVVQVEREKTEA--EPTHVNEEKLEHETAVTVSEEVS--KQLLQ 1278
LQ + E + +++ E TEA + + V EE + EE+S K ++
Sbjct: 2160 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM---EELSKLKARIE 2216
Query: 1279 TVNVPII----DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE----- 1329
N +I D + E + +E A ++ V + EA+ A E+
Sbjct: 2217 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---RLSVAAQEAARLRQLAEEDLAQQR 2273
Query: 1330 ---EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1386
EK+L E ++ L+ A A L+ ++K E ++ A ED K
Sbjct: 2274 ALAEKMLKEKMQAVQEATRLK-AEAELLQQQK--ELAQEQARRLQED----------KEQ 2320
Query: 1387 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1446
A +G LE E+ L+ ++ E++ + ++S A E
Sbjct: 2321 MAQQLAEETQGFQRTLEAERQRQLEMSAEA--ERLKLRVAEMSRA--QARAEEDAQRFRK 2376
Query: 1447 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADS-QDAGQETEKEGEEPQA 1505
++ ++ + + +T + T+E T + T E+Q Q A+ ++A E E+E E+ Q
Sbjct: 2377 QAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2432
Query: 1506 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1565
A K + SE+ TV+ E Q L++ L S
Sbjct: 2433 EA--------------------------KLLQLKSEEMQTVQQEQLLQETQALQQSFL-S 2465
Query: 1566 EEEGGGAGTKSVPEDDG--HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASG 1623
E++ + + ++ L + + K+ +E ++ + E Q +A + +
Sbjct: 2466 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR-LVASMEEAR 2524
Query: 1624 GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQER 1674
E+ + KQ+E + ++ Q+ ++ +E ++ + Q Q L++Q R
Sbjct: 2525 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHR 2574
Score = 52.4 bits (124), Expect = 4e-06
Identities = 179/996 (17%), Positives = 359/996 (36%), Gaps = 124/996 (12%)
Query: 733 AGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVH 792
A PT +E + + + + A+ EK++ Q ++ ++L E+Q
Sbjct: 1027 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1086
Query: 793 MMAAAVADGTRAA-----TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE 847
+ T+A+ E + P++ ++ + L + L + ER+V E
Sbjct: 1087 PATLPELEATKASLKKLRAQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVER 1144
Query: 848 EPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEETTEM 904
V + L + T V + EL + E+A PLGA E+ M
Sbjct: 1145 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1204
Query: 905 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK----VKEESQLPG 960
A SQ E+A ++E+E +EE +R ++ + A+ + V ++QL
Sbjct: 1205 PLADSQAVREQLRQEQAL-LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1261
Query: 961 TGGPEDVLQPVQRAEAERPEEQA--EASGLKKETDVVLKVDAQEAKTEPFT------QGK 1012
E V P ++ + + E E L+ + + +Q K T + +
Sbjct: 1262 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1317
Query: 1013 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1072
+ Q E E+ +V ++E + A+ A + + ++Q + + V
Sbjct: 1318 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR----- 1372
Query: 1073 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1132
D + ++E+ ++ + +E Q+ +AEA + R +
Sbjct: 1373 ---EEAAVDAQQQKRSIQEELQQLRQSSEAE--IQAKARQAEAAERSRLR--------IE 1419
Query: 1133 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDT 1192
EE + + E E ++ ++ E + + A E+ E L +
Sbjct: 1420 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQVQD 1473
Query: 1193 GITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEP 1252
R+ E+A + + EA +K AL+ R + ER +AE
Sbjct: 1474 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--------RLQAEEAERRLRQAEV 1525
Query: 1253 THVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKI 1312
+ ++ ETA +E LQ+ A++ + LE S L +E ++
Sbjct: 1526 ERARQVQVALETAQRSAEAE----LQSKRASF---AEKTAQLERS----LQEEHVAVAQL 1574
Query: 1313 QVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGE 1372
+ EA AE E+ E LE + L L+ + + + A
Sbjct: 1575 R---EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA----- 1626
Query: 1373 DAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI 1432
QA++ A + E + + E+++Q +++ A
Sbjct: 1627 ---------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQ 1674
Query: 1433 EDLEPENGILEL--ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1490
+ L E ++ L ET+ + + +++ + + R AT+ EL+ + ++A+ +
Sbjct: 1675 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK-RQELEAELAKVRAEME 1733
Query: 1491 -----DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSE-ASEKTM 1544
A E E ++ + E +E +E A +A ++ +K + A E
Sbjct: 1734 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1793
Query: 1545 TVEVEGSTVNDQQL-----------EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1593
E V ++L E + E+E + + ED+ A R+E+
Sbjct: 1794 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE--AFQRRRLEEQ 1851
Query: 1594 LVEPKED--------EKGDDVDDPENQNSALADT-DASGGLTKESPDTNGPKQKEKEDAQ 1644
+ K D K D + E Q + DT + +E +K
Sbjct: 1852 AAQHKADIEERLAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910
Query: 1645 EVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1680
E+EL+ G++ S ++ + + Q EL+ + +E
Sbjct: 1911 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1946
Score = 45.4 bits (106), Expect = 5e-04
Identities = 184/981 (18%), Positives = 369/981 (37%), Gaps = 114/981 (11%)
Query: 24 KEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEE-LTQPTESQANDIGFKKVFKFVG 82
KE ++ + + +D + + EQ ++++EE L Q ++ +++ +K G
Sbjct: 1825 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----G 1879
Query: 83 FKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGD----------HKDPSLGAGEAASKES 132
+ + + + ++L +K + AAG + + + +L + E A E+
Sbjct: 1880 LVEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1937
Query: 133 EPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTS 192
++ EE +RE A +A + K EE E+ +K E+ +
Sbjct: 1938 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERA 1996
Query: 193 ETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEED---GKAEVAS 249
E S + Q A ++ + K V+ E++ +Q ++ + D G+AE A
Sbjct: 1997 EQESARQLQLAQE-AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2055
Query: 250 EKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK 309
+E+A Q E+A R E E+++ +EEQ ++ ++ L E E
Sbjct: 2056 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-ARAQAQAAAEKLRKEAEQEA 2114
Query: 310 IEVHQEEVVAEVHVSTVEERTEEQKTEVEET--AGSVPAEELVEMDAEPQEAEPAKELVK 367
Q E A + E+ K E+T + +EL + + +E + K L+
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2174
Query: 368 LKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS-QERMKVQGSPL-------- 418
+ + E S E+ L V ++E LS + R++ + L
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELF----SVRVQMEELSKLKARIEAENRALILRDKDNT 2230
Query: 419 KKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEI 478
++ K ++ + +E+ Q+ + Q + + +E
Sbjct: 2231 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2290
Query: 479 TCLEKGLAEVQQDGE-AEEGATSDGEKKREGVTPWA----SFKKMVTPKKRVRRPSESDK 533
T L+ +QQ E A+E A E K + A F++ + ++ +R E
Sbjct: 2291 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--QRQLEMSA 2348
Query: 534 EDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKR 593
E E K++ A +S ++ A E + + EE + + T ++ + + + + +
Sbjct: 2349 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR----TELATQEKVTLVQTLEI 2404
Query: 594 ARRGSSSDEEGGPKAMG---GDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAG 650
R+ S D E +A+ + +K + K + ++ + QE + + Q
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE--TQALQQS 2462
Query: 651 SPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK 710
+E + + E F ++ K+KLE+ +D +A + +EE
Sbjct: 2463 FLSEKDSLLQRERF------IEQEKAKLEQLFQDEVA---------KAQQLREEQ----- 2502
Query: 711 KFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKS 770
+R+++ ++ Q V + +++ + V R++ E QQ ++
Sbjct: 2503 -----QRQQQQMEQERQRLVASMEEARRRQHEAE----------EGVRRKQEELQQLEQQ 2547
Query: 771 AEQPEQKAATEVSK-----ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLE 825
Q E+ A E + +L E Q H A A ++ A+ + ++ ++ P
Sbjct: 2548 RRQQEELLAEENQRLREQLQLLEEQ-HRAALAHSEEVTASQVAATKTLPNGRDALDGPAA 2606
Query: 826 QVEAEAALLTEEVLEREVIAEE-EPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETA 884
+ E E + + L R+V A+ + + R A+G T V E + +
Sbjct: 2607 EAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGR 2663
Query: 885 GPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEV 944
+ G A E + +A+ + SP T Q G + D R T
Sbjct: 2664 SSIA---GLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLT--- 2717
Query: 945 LQAVAEKVKEESQLPGTGGPE 965
V E VKE G GPE
Sbjct: 2718 ---VNEAVKE-----GVVGPE 2730
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 73.6 bits (179), Expect = 2e-12
Identities = 228/1214 (18%), Positives = 451/1214 (37%), Gaps = 194/1214 (15%)
Query: 126 EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEE-----KQEKEPS 180
EAA + K+S ++ + L R+ S AEI A +A E + EE + + E +
Sbjct: 1543 EAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1601
Query: 181 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 240
+ + ++ Q + R+ +DE S++K++ E E + +
Sbjct: 1602 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVE-LASR 1657
Query: 241 EDGKAEVASEK-----------LTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 289
+AE A EK L A E AE ++ E + +E ++
Sbjct: 1658 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1717
Query: 290 SQGPSEEKPAPLATEVFDEKIEVHQ--EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE 347
+ EK A L + +E + V Q EE ER E+ E E + A
Sbjct: 1718 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-AERELERWQLKAN 1776
Query: 348 ELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS 407
E + + + +E K L + E Q + + + K E V + E+
Sbjct: 1777 EALRLRLQAEEVAQQKSLAQ-------AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829
Query: 408 Q---ERMKVQGSPLKKLFTSTGLKKLSGKKQKG--KRGGGDEESGEHTQVPADSPDSQEE 462
+ +R +G+ ++L L +L + ++G +R +EE + A + +Q+
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--TQKR 1887
Query: 463 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG---ATSDGEKKREGVTPWASFKKMV 519
Q+ E+ + E+ K AE + +E+ ++ + RE A + +
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1947
Query: 520 TPKKRVRRPSESD---KEDELDKVKSATLSST-ESTASEMQEEMKGSVEEPKPEEPKRKV 575
KR R+ +E D + E ++V + L++ E+T + + E+ +E + E +R
Sbjct: 1948 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 2007
Query: 576 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 635
+ + ++R ++ + + +KA ++ +++ G L
Sbjct: 2008 EDE----------AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG----LVEDT 2053
Query: 636 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 695
Q + E E L R ++ L K + + +
Sbjct: 2054 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 2113
Query: 696 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 755
+ E + E+ ++K + + +Q +A +E+
Sbjct: 2114 AEEERRRREAEERVQKSLAAEEEA---ARQRKAALEE----------------------- 2147
Query: 756 AVEREKMEAQQAQKSAEQPEQKAATEV-------SKEL-SESQVHMMAAAVADGTRAATI 807
VER K + ++A++ E+ EQ++A ++ K L +E + H A + T+
Sbjct: 2148 -VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2206
Query: 808 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 867
+E+ SV + L + EAEAA E E + E + E E +
Sbjct: 2207 QQEQ-------SVLDQL-RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2258
Query: 868 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 927
+A+ +A AAE +E + AE+ +++
Sbjct: 2259 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA---------------------LRQK 2297
Query: 928 EGGVPDIEEQERRTQEVLQAVAEKVKE----ESQLPGTGGPEDVL-QPVQRAEAERPEEQ 982
+ ++E+ ++ ++ L+ A+ +E QL T +++L + +QR +AE E
Sbjct: 2298 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2357
Query: 983 AEASGLKKETDVVLKVDAQE-----AKTEPFTQGKVV------GQTTPESFEKAPQVTES 1031
+ S +++E V +V +E A+ E + ++ + E EK QV E
Sbjct: 2358 RQRSQVEEELFSV-RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE- 2415
Query: 1032 IESSEL-VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1090
E++ L V +A L + +++ ++A+ ++ + + T K
Sbjct: 2416 -EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-----------ATRLK 2463
Query: 1091 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE---H 1147
E + ++ E+A +A + KE+ + Q+ +E + TLE
Sbjct: 2464 AEAELLQQQKELAQ------EQARRLQEDKEQ-------MAQQLAEETQGFQRTLEAERQ 2510
Query: 1148 TDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALK 1207
E+S E + + A A+E + R++ E+ K
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----------------RKQAEEIGEK 2553
Query: 1208 GEGTEEAECKK---DDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1264
TE A +K LE+Q + RE + ++EREK + + +L+ E
Sbjct: 2554 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ-QEAKLLQLKSEE 2612
Query: 1265 AVTVSEEVSKQLLQ 1278
TV +E QLLQ
Sbjct: 2613 MQTVQQE---QLLQ 2623
Score = 68.6 bits (166), Expect = 5e-11
Identities = 263/1431 (18%), Positives = 535/1431 (37%), Gaps = 181/1431 (12%)
Query: 272 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 331
L+++Y K + ++ + +E++ A + + + + ++ +AE H +
Sbjct: 1466 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1525
Query: 332 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 391
E K + V E +DA+ Q+ +EL +L++ S + ++
Sbjct: 1526 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ--------------SSEAEIQ 1571
Query: 392 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 451
+K + +E L +E ++V +L + + +RGG + E + +
Sbjct: 1572 AKARQAEAAERSRLRIEEEIRV--------------VRLQLEATERQRGGAEGEL-QALR 1616
Query: 452 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTP 511
A+ ++Q+ Q E + + ++ K AEV+ + A + EK+R
Sbjct: 1617 ARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQR----A 1671
Query: 512 WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEP 571
+ +++ + R + + +V+ A ++ S +E+Q + E K +
Sbjct: 1672 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQL 1729
Query: 572 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 631
+R + E + V ++ A R + E + + K E +
Sbjct: 1730 ERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784
Query: 632 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 691
A + E+ E E ++ ++ V R+ ++ +LE++ + +
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------L 1837
Query: 692 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 751
T E+ + + R + G+Q++ +E+ E + L
Sbjct: 1838 AEGTAQQRLAAEQELIRL-------RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890
Query: 752 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER 811
A R +ME A K+ + E ++ +E SK+ E++ + R + EE
Sbjct: 1891 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1950
Query: 812 SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA 871
A ++ EAE L + E + T E + +EA + + A
Sbjct: 1951 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK---TEAEIALKEKEAENERLRRLA 2007
Query: 872 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 931
E EA E AA+ ++ ++QL + D + ++ +G V
Sbjct: 2008 E--DEAF----------QRRRLEEQAAQHKADIEERLAQLRKASD-----SELERQKGLV 2050
Query: 932 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGL 988
D Q R+ +E + +A K E G E L + R+ AE R +EQAE
Sbjct: 2051 EDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAA 2107
Query: 989 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTC--QAETL 1046
++ ++ A+E + + +V E E A Q ++E E + +A L
Sbjct: 2108 RQR-----QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRL 2161
Query: 1047 AGVKSQEMVMEQAIPPDSVETPTDSETDG---STPVADFDAPGTTQKDEIVEIHEENEVA 1103
QE + + ++ + +E + + + T Q+++ V + + A
Sbjct: 2162 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV-LDQLRGEA 2220
Query: 1104 SGTQSGGTEAEAVPAQKERPPAPSSFVFQE-ETKEQSKMEDTLEHTDKEVSVETVSILSK 1162
+ EAE Q ER A S +E E +QS E + + E + +
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL----R 2276
Query: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1222
E QEA + A + + + + ++ +K E L+ + E E L
Sbjct: 2277 KEAEQEAARRAQAEQAALRQKQAADAEME-----KHKKFAEQTLRQKAQVEQEL---TTL 2328
Query: 1223 ELQSHAKSPPSPVEREMVVQVEREKTEA--EPTHVNEEKLEHETAVTVSEEVS--KQLLQ 1278
LQ + E + +++ E TEA + + V EE + EE+S K ++
Sbjct: 2329 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM---EELSKLKARIE 2385
Query: 1279 TVNVPII----DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE----- 1329
N +I D + E + +E A ++ V + EA+ A E+
Sbjct: 2386 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---RLSVAAQEAARLRQLAEEDLAQQR 2442
Query: 1330 ---EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1386
EK+L E ++ L+ A A L+ ++K E ++ A ED K
Sbjct: 2443 ALAEKMLKEKMQAVQEATRLK-AEAELLQQQK--ELAQEQARRLQED----------KEQ 2489
Query: 1387 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1446
A +G LE E+ L+ ++ E++ + ++S A E
Sbjct: 2490 MAQQLAEETQGFQRTLEAERQRQLEMSAEA--ERLKLRVAEMSRA--QARAEEDAQRFRK 2545
Query: 1447 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADS-QDAGQETEKEGEEPQA 1505
++ ++ + + +T + T+E T + T E+Q Q A+ ++A E E+E E+ Q
Sbjct: 2546 QAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2601
Query: 1506 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1565
A K + SE+ TV+ E Q L++ L S
Sbjct: 2602 EA--------------------------KLLQLKSEEMQTVQQEQLLQETQALQQSFL-S 2634
Query: 1566 EEEGGGAGTKSVPEDDG--HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASG 1623
E++ + + ++ L + + K+ +E ++ + E Q +A + +
Sbjct: 2635 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR-LVASMEEAR 2693
Query: 1624 GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQER 1674
E+ + KQ+E + ++ Q+ ++ +E ++ + Q Q L++Q R
Sbjct: 2694 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHR 2743
Score = 52.4 bits (124), Expect = 4e-06
Identities = 179/996 (17%), Positives = 359/996 (36%), Gaps = 124/996 (12%)
Query: 733 AGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVH 792
A PT +E + + + + A+ EK++ Q ++ ++L E+Q
Sbjct: 1196 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1255
Query: 793 MMAAAVADGTRAA-----TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE 847
+ T+A+ E + P++ ++ + L + L + ER+V E
Sbjct: 1256 PATLPELEATKASLKKLRAQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVER 1313
Query: 848 EPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEETTEM 904
V + L + T V + EL + E+A PLGA E+ M
Sbjct: 1314 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1373
Query: 905 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK----VKEESQLPG 960
A SQ E+A ++E+E +EE +R ++ + A+ + V ++QL
Sbjct: 1374 PLADSQAVREQLRQEQAL-LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1430
Query: 961 TGGPEDVLQPVQRAEAERPEEQA--EASGLKKETDVVLKVDAQEAKTEPFT------QGK 1012
E V P ++ + + E E L+ + + +Q K T + +
Sbjct: 1431 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1486
Query: 1013 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1072
+ Q E E+ +V ++E + A+ A + + ++Q + + V
Sbjct: 1487 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR----- 1541
Query: 1073 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1132
D + ++E+ ++ + +E Q+ +AEA + R +
Sbjct: 1542 ---EEAAVDAQQQKRSIQEELQQLRQSSEAE--IQAKARQAEAAERSRLR--------IE 1588
Query: 1133 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDT 1192
EE + + E E ++ ++ E + + A E+ E L +
Sbjct: 1589 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQVQD 1642
Query: 1193 GITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEP 1252
R+ E+A + + EA +K AL+ R + ER +AE
Sbjct: 1643 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--------RLQAEEAERRLRQAEV 1694
Query: 1253 THVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKI 1312
+ ++ ETA +E LQ+ A++ + LE S L +E ++
Sbjct: 1695 ERARQVQVALETAQRSAEAE----LQSKRASF---AEKTAQLERS----LQEEHVAVAQL 1743
Query: 1313 QVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGE 1372
+ EA AE E+ E LE + L L+ + + + A
Sbjct: 1744 R---EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA----- 1795
Query: 1373 DAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI 1432
QA++ A + E + + E+++Q +++ A
Sbjct: 1796 ---------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQ 1843
Query: 1433 EDLEPENGILEL--ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1490
+ L E ++ L ET+ + + +++ + + R AT+ EL+ + ++A+ +
Sbjct: 1844 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK-RQELEAELAKVRAEME 1902
Query: 1491 -----DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSE-ASEKTM 1544
A E E ++ + E +E +E A +A ++ +K + A E
Sbjct: 1903 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1962
Query: 1545 TVEVEGSTVNDQQL-----------EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1593
E V ++L E + E+E + + ED+ A R+E+
Sbjct: 1963 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE--AFQRRRLEEQ 2020
Query: 1594 LVEPKED--------EKGDDVDDPENQNSALADT-DASGGLTKESPDTNGPKQKEKEDAQ 1644
+ K D K D + E Q + DT + +E +K
Sbjct: 2021 AAQHKADIEERLAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079
Query: 1645 EVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1680
E+EL+ G++ S ++ + + Q EL+ + +E
Sbjct: 2080 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2115
Score = 45.4 bits (106), Expect = 5e-04
Identities = 184/981 (18%), Positives = 369/981 (37%), Gaps = 114/981 (11%)
Query: 24 KEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEE-LTQPTESQANDIGFKKVFKFVG 82
KE ++ + + +D + + EQ ++++EE L Q ++ +++ +K G
Sbjct: 1994 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----G 2048
Query: 83 FKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGD----------HKDPSLGAGEAASKES 132
+ + + + ++L +K + AAG + + + +L + E A E+
Sbjct: 2049 LVEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 2106
Query: 133 EPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTS 192
++ EE +RE A +A + K EE E+ +K E+ +
Sbjct: 2107 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERA 2165
Query: 193 ETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEED---GKAEVAS 249
E S + Q A ++ + K V+ E++ +Q ++ + D G+AE A
Sbjct: 2166 EQESARQLQLAQE-AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2224
Query: 250 EKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK 309
+E+A Q E+A R E E+++ +EEQ ++ ++ L E E
Sbjct: 2225 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-ARAQAQAAAEKLRKEAEQEA 2283
Query: 310 IEVHQEEVVAEVHVSTVEERTEEQKTEVEET--AGSVPAEELVEMDAEPQEAEPAKELVK 367
Q E A + E+ K E+T + +EL + + +E + K L+
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343
Query: 368 LKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS-QERMKVQGSPL-------- 418
+ + E S E+ L V ++E LS + R++ + L
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELF----SVRVQMEELSKLKARIEAENRALILRDKDNT 2399
Query: 419 KKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEI 478
++ K ++ + +E+ Q+ + Q + + +E
Sbjct: 2400 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2459
Query: 479 TCLEKGLAEVQQDGE-AEEGATSDGEKKREGVTPWA----SFKKMVTPKKRVRRPSESDK 533
T L+ +QQ E A+E A E K + A F++ + ++ +R E
Sbjct: 2460 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--QRQLEMSA 2517
Query: 534 EDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKR 593
E E K++ A +S ++ A E + + EE + + T ++ + + + + +
Sbjct: 2518 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR----TELATQEKVTLVQTLEI 2573
Query: 594 ARRGSSSDEEGGPKAMG---GDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAG 650
R+ S D E +A+ + +K + K + ++ + QE + + Q
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE--TQALQQS 2631
Query: 651 SPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK 710
+E + + E F ++ K+KLE+ +D +A + +EE
Sbjct: 2632 FLSEKDSLLQRERF------IEQEKAKLEQLFQDEVA---------KAQQLREEQ----- 2671
Query: 711 KFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKS 770
+R+++ ++ Q V + +++ + V R++ E QQ ++
Sbjct: 2672 -----QRQQQQMEQERQRLVASMEEARRRQHEAE----------EGVRRKQEELQQLEQQ 2716
Query: 771 AEQPEQKAATEVSK-----ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLE 825
Q E+ A E + +L E Q H A A ++ A+ + ++ ++ P
Sbjct: 2717 RRQQEELLAEENQRLREQLQLLEEQ-HRAALAHSEEVTASQVAATKTLPNGRDALDGPAA 2775
Query: 826 QVEAEAALLTEEVLEREVIAEE-EPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETA 884
+ E E + + L R+V A+ + + R A+G T V E + +
Sbjct: 2776 EAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGR 2832
Query: 885 GPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEV 944
+ G A E + +A+ + SP T Q G + D R T
Sbjct: 2833 SSIA---GLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLT--- 2886
Query: 945 LQAVAEKVKEESQLPGTGGPE 965
V E VKE G GPE
Sbjct: 2887 ---VNEAVKE-----GVVGPE 2899
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 73.6 bits (179), Expect = 2e-12
Identities = 228/1214 (18%), Positives = 451/1214 (37%), Gaps = 194/1214 (15%)
Query: 126 EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEE-----KQEKEPS 180
EAA + K+S ++ + L R+ S AEI A +A E + EE + + E +
Sbjct: 1384 EAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1442
Query: 181 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 240
+ + ++ Q + R+ +DE S++K++ E E + +
Sbjct: 1443 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVE-LASR 1498
Query: 241 EDGKAEVASEK-----------LTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 289
+AE A EK L A E AE ++ E + +E ++
Sbjct: 1499 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1558
Query: 290 SQGPSEEKPAPLATEVFDEKIEVHQ--EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE 347
+ EK A L + +E + V Q EE ER E+ E E + A
Sbjct: 1559 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-AERELERWQLKAN 1617
Query: 348 ELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS 407
E + + + +E K L + E Q + + + K E V + E+
Sbjct: 1618 EALRLRLQAEEVAQQKSLAQ-------AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1670
Query: 408 Q---ERMKVQGSPLKKLFTSTGLKKLSGKKQKG--KRGGGDEESGEHTQVPADSPDSQEE 462
+ +R +G+ ++L L +L + ++G +R +EE + A + +Q+
Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--TQKR 1728
Query: 463 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG---ATSDGEKKREGVTPWASFKKMV 519
Q+ E+ + E+ K AE + +E+ ++ + RE A + +
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1788
Query: 520 TPKKRVRRPSESD---KEDELDKVKSATLSST-ESTASEMQEEMKGSVEEPKPEEPKRKV 575
KR R+ +E D + E ++V + L++ E+T + + E+ +E + E +R
Sbjct: 1789 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1848
Query: 576 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 635
+ + ++R ++ + + +KA ++ +++ G L
Sbjct: 1849 EDE----------AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG----LVEDT 1894
Query: 636 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 695
Q + E E L R ++ L K + + +
Sbjct: 1895 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1954
Query: 696 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 755
+ E + E+ ++K + + +Q +A +E+
Sbjct: 1955 AEEERRRREAEERVQKSLAAEEEA---ARQRKAALEE----------------------- 1988
Query: 756 AVEREKMEAQQAQKSAEQPEQKAATEV-------SKEL-SESQVHMMAAAVADGTRAATI 807
VER K + ++A++ E+ EQ++A ++ K L +E + H A + T+
Sbjct: 1989 -VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2047
Query: 808 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 867
+E+ SV + L + EAEAA E E + E + E E +
Sbjct: 2048 QQEQ-------SVLDQL-RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2099
Query: 868 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 927
+A+ +A AAE +E + AE+ +++
Sbjct: 2100 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA---------------------LRQK 2138
Query: 928 EGGVPDIEEQERRTQEVLQAVAEKVKE----ESQLPGTGGPEDVL-QPVQRAEAERPEEQ 982
+ ++E+ ++ ++ L+ A+ +E QL T +++L + +QR +AE E
Sbjct: 2139 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2198
Query: 983 AEASGLKKETDVVLKVDAQE-----AKTEPFTQGKVV------GQTTPESFEKAPQVTES 1031
+ S +++E V +V +E A+ E + ++ + E EK QV E
Sbjct: 2199 RQRSQVEEELFSV-RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE- 2256
Query: 1032 IESSEL-VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1090
E++ L V +A L + +++ ++A+ ++ + + T K
Sbjct: 2257 -EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-----------ATRLK 2304
Query: 1091 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE---H 1147
E + ++ E+A +A + KE+ + Q+ +E + TLE
Sbjct: 2305 AEAELLQQQKELAQ------EQARRLQEDKEQ-------MAQQLAEETQGFQRTLEAERQ 2351
Query: 1148 TDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALK 1207
E+S E + + A A+E + R++ E+ K
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----------------RKQAEEIGEK 2394
Query: 1208 GEGTEEAECKK---DDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1264
TE A +K LE+Q + RE + ++EREK + + +L+ E
Sbjct: 2395 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ-QEAKLLQLKSEE 2453
Query: 1265 AVTVSEEVSKQLLQ 1278
TV +E QLLQ
Sbjct: 2454 MQTVQQE---QLLQ 2464
Score = 68.6 bits (166), Expect = 5e-11
Identities = 263/1431 (18%), Positives = 535/1431 (37%), Gaps = 181/1431 (12%)
Query: 272 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 331
L+++Y K + ++ + +E++ A + + + + ++ +AE H +
Sbjct: 1307 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1366
Query: 332 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 391
E K + V E +DA+ Q+ +EL +L++ S + ++
Sbjct: 1367 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ--------------SSEAEIQ 1412
Query: 392 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 451
+K + +E L +E ++V +L + + +RGG + E + +
Sbjct: 1413 AKARQAEAAERSRLRIEEEIRV--------------VRLQLEATERQRGGAEGEL-QALR 1457
Query: 452 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTP 511
A+ ++Q+ Q E + + ++ K AEV+ + A + EK+R
Sbjct: 1458 ARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQR----A 1512
Query: 512 WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEP 571
+ +++ + R + + +V+ A ++ S +E+Q + E K +
Sbjct: 1513 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQL 1570
Query: 572 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 631
+R + E + V ++ A R + E + + K E +
Sbjct: 1571 ERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1625
Query: 632 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 691
A + E+ E E ++ ++ V R+ ++ +LE++ + +
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------L 1678
Query: 692 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 751
T E+ + + R + G+Q++ +E+ E + L
Sbjct: 1679 AEGTAQQRLAAEQELIRL-------RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1731
Query: 752 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER 811
A R +ME A K+ + E ++ +E SK+ E++ + R + EE
Sbjct: 1732 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1791
Query: 812 SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA 871
A ++ EAE L + E + T E + +EA + + A
Sbjct: 1792 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK---TEAEIALKEKEAENERLRRLA 1848
Query: 872 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 931
E EA E AA+ ++ ++QL + D + ++ +G V
Sbjct: 1849 E--DEAF----------QRRRLEEQAAQHKADIEERLAQLRKASD-----SELERQKGLV 1891
Query: 932 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGL 988
D Q R+ +E + +A K E G E L + R+ AE R +EQAE
Sbjct: 1892 EDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAA 1948
Query: 989 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTC--QAETL 1046
++ ++ A+E + + +V E E A Q ++E E + +A L
Sbjct: 1949 RQR-----QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRL 2002
Query: 1047 AGVKSQEMVMEQAIPPDSVETPTDSETDG---STPVADFDAPGTTQKDEIVEIHEENEVA 1103
QE + + ++ + +E + + + T Q+++ V + + A
Sbjct: 2003 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV-LDQLRGEA 2061
Query: 1104 SGTQSGGTEAEAVPAQKERPPAPSSFVFQE-ETKEQSKMEDTLEHTDKEVSVETVSILSK 1162
+ EAE Q ER A S +E E +QS E + + E + +
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL----R 2117
Query: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1222
E QEA + A + + + + ++ +K E L+ + E E L
Sbjct: 2118 KEAEQEAARRAQAEQAALRQKQAADAEME-----KHKKFAEQTLRQKAQVEQEL---TTL 2169
Query: 1223 ELQSHAKSPPSPVEREMVVQVEREKTEA--EPTHVNEEKLEHETAVTVSEEVS--KQLLQ 1278
LQ + E + +++ E TEA + + V EE + EE+S K ++
Sbjct: 2170 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM---EELSKLKARIE 2226
Query: 1279 TVNVPII----DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE----- 1329
N +I D + E + +E A ++ V + EA+ A E+
Sbjct: 2227 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---RLSVAAQEAARLRQLAEEDLAQQR 2283
Query: 1330 ---EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1386
EK+L E ++ L+ A A L+ ++K E ++ A ED K
Sbjct: 2284 ALAEKMLKEKMQAVQEATRLK-AEAELLQQQK--ELAQEQARRLQED----------KEQ 2330
Query: 1387 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1446
A +G LE E+ L+ ++ E++ + ++S A E
Sbjct: 2331 MAQQLAEETQGFQRTLEAERQRQLEMSAEA--ERLKLRVAEMSRA--QARAEEDAQRFRK 2386
Query: 1447 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADS-QDAGQETEKEGEEPQA 1505
++ ++ + + +T + T+E T + T E+Q Q A+ ++A E E+E E+ Q
Sbjct: 2387 QAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2442
Query: 1506 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1565
A K + SE+ TV+ E Q L++ L S
Sbjct: 2443 EA--------------------------KLLQLKSEEMQTVQQEQLLQETQALQQSFL-S 2475
Query: 1566 EEEGGGAGTKSVPEDDG--HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASG 1623
E++ + + ++ L + + K+ +E ++ + E Q +A + +
Sbjct: 2476 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR-LVASMEEAR 2534
Query: 1624 GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQER 1674
E+ + KQ+E + ++ Q+ ++ +E ++ + Q Q L++Q R
Sbjct: 2535 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHR 2584
Score = 52.4 bits (124), Expect = 4e-06
Identities = 179/996 (17%), Positives = 359/996 (36%), Gaps = 124/996 (12%)
Query: 733 AGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVH 792
A PT +E + + + + A+ EK++ Q ++ ++L E+Q
Sbjct: 1037 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1096
Query: 793 MMAAAVADGTRAA-----TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE 847
+ T+A+ E + P++ ++ + L + L + ER+V E
Sbjct: 1097 PATLPELEATKASLKKLRAQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVER 1154
Query: 848 EPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEETTEM 904
V + L + T V + EL + E+A PLGA E+ M
Sbjct: 1155 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1214
Query: 905 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK----VKEESQLPG 960
A SQ E+A ++E+E +EE +R ++ + A+ + V ++QL
Sbjct: 1215 PLADSQAVREQLRQEQAL-LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1271
Query: 961 TGGPEDVLQPVQRAEAERPEEQA--EASGLKKETDVVLKVDAQEAKTEPFT------QGK 1012
E V P ++ + + E E L+ + + +Q K T + +
Sbjct: 1272 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1327
Query: 1013 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1072
+ Q E E+ +V ++E + A+ A + + ++Q + + V
Sbjct: 1328 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR----- 1382
Query: 1073 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1132
D + ++E+ ++ + +E Q+ +AEA + R +
Sbjct: 1383 ---EEAAVDAQQQKRSIQEELQQLRQSSEAE--IQAKARQAEAAERSRLR--------IE 1429
Query: 1133 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDT 1192
EE + + E E ++ ++ E + + A E+ E L +
Sbjct: 1430 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQVQD 1483
Query: 1193 GITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEP 1252
R+ E+A + + EA +K AL+ R + ER +AE
Sbjct: 1484 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--------RLQAEEAERRLRQAEV 1535
Query: 1253 THVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKI 1312
+ ++ ETA +E LQ+ A++ + LE S L +E ++
Sbjct: 1536 ERARQVQVALETAQRSAEAE----LQSKRASF---AEKTAQLERS----LQEEHVAVAQL 1584
Query: 1313 QVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGE 1372
+ EA AE E+ E LE + L L+ + + + A
Sbjct: 1585 R---EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA----- 1636
Query: 1373 DAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI 1432
QA++ A + E + + E+++Q +++ A
Sbjct: 1637 ---------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQ 1684
Query: 1433 EDLEPENGILEL--ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1490
+ L E ++ L ET+ + + +++ + + R AT+ EL+ + ++A+ +
Sbjct: 1685 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK-RQELEAELAKVRAEME 1743
Query: 1491 -----DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSE-ASEKTM 1544
A E E ++ + E +E +E A +A ++ +K + A E
Sbjct: 1744 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1803
Query: 1545 TVEVEGSTVNDQQL-----------EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1593
E V ++L E + E+E + + ED+ A R+E+
Sbjct: 1804 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE--AFQRRRLEEQ 1861
Query: 1594 LVEPKED--------EKGDDVDDPENQNSALADT-DASGGLTKESPDTNGPKQKEKEDAQ 1644
+ K D K D + E Q + DT + +E +K
Sbjct: 1862 AAQHKADIEERLAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920
Query: 1645 EVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1680
E+EL+ G++ S ++ + + Q EL+ + +E
Sbjct: 1921 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1956
Score = 45.4 bits (106), Expect = 5e-04
Identities = 184/981 (18%), Positives = 369/981 (37%), Gaps = 114/981 (11%)
Query: 24 KEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEE-LTQPTESQANDIGFKKVFKFVG 82
KE ++ + + +D + + EQ ++++EE L Q ++ +++ +K G
Sbjct: 1835 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----G 1889
Query: 83 FKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGD----------HKDPSLGAGEAASKES 132
+ + + + ++L +K + AAG + + + +L + E A E+
Sbjct: 1890 LVEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1947
Query: 133 EPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTS 192
++ EE +RE A +A + K EE E+ +K E+ +
Sbjct: 1948 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERA 2006
Query: 193 ETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEED---GKAEVAS 249
E S + Q A ++ + K V+ E++ +Q ++ + D G+AE A
Sbjct: 2007 EQESARQLQLAQE-AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2065
Query: 250 EKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK 309
+E+A Q E+A R E E+++ +EEQ ++ ++ L E E
Sbjct: 2066 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-ARAQAQAAAEKLRKEAEQEA 2124
Query: 310 IEVHQEEVVAEVHVSTVEERTEEQKTEVEET--AGSVPAEELVEMDAEPQEAEPAKELVK 367
Q E A + E+ K E+T + +EL + + +E + K L+
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
Query: 368 LKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS-QERMKVQGSPL-------- 418
+ + E S E+ L V ++E LS + R++ + L
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELF----SVRVQMEELSKLKARIEAENRALILRDKDNT 2240
Query: 419 KKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEI 478
++ K ++ + +E+ Q+ + Q + + +E
Sbjct: 2241 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2300
Query: 479 TCLEKGLAEVQQDGE-AEEGATSDGEKKREGVTPWA----SFKKMVTPKKRVRRPSESDK 533
T L+ +QQ E A+E A E K + A F++ + ++ +R E
Sbjct: 2301 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--QRQLEMSA 2358
Query: 534 EDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKR 593
E E K++ A +S ++ A E + + EE + + T ++ + + + + +
Sbjct: 2359 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR----TELATQEKVTLVQTLEI 2414
Query: 594 ARRGSSSDEEGGPKAMG---GDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAG 650
R+ S D E +A+ + +K + K + ++ + QE + + Q
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE--TQALQQS 2472
Query: 651 SPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK 710
+E + + E F ++ K+KLE+ +D +A + +EE
Sbjct: 2473 FLSEKDSLLQRERF------IEQEKAKLEQLFQDEVA---------KAQQLREEQ----- 2512
Query: 711 KFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKS 770
+R+++ ++ Q V + +++ + V R++ E QQ ++
Sbjct: 2513 -----QRQQQQMEQERQRLVASMEEARRRQHEAE----------EGVRRKQEELQQLEQQ 2557
Query: 771 AEQPEQKAATEVSK-----ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLE 825
Q E+ A E + +L E Q H A A ++ A+ + ++ ++ P
Sbjct: 2558 RRQQEELLAEENQRLREQLQLLEEQ-HRAALAHSEEVTASQVAATKTLPNGRDALDGPAA 2616
Query: 826 QVEAEAALLTEEVLEREVIAEE-EPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETA 884
+ E E + + L R+V A+ + + R A+G T V E + +
Sbjct: 2617 EAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGR 2673
Query: 885 GPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEV 944
+ G A E + +A+ + SP T Q G + D R T
Sbjct: 2674 SSIA---GLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLT--- 2727
Query: 945 LQAVAEKVKEESQLPGTGGPE 965
V E VKE G GPE
Sbjct: 2728 ---VNEAVKE-----GVVGPE 2740
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 73.6 bits (179), Expect = 2e-12
Identities = 228/1214 (18%), Positives = 451/1214 (37%), Gaps = 194/1214 (15%)
Query: 126 EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEE-----KQEKEPS 180
EAA + K+S ++ + L R+ S AEI A +A E + EE + + E +
Sbjct: 1392 EAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1450
Query: 181 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 240
+ + ++ Q + R+ +DE S++K++ E E + +
Sbjct: 1451 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVE-LASR 1506
Query: 241 EDGKAEVASEK-----------LTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 289
+AE A EK L A E AE ++ E + +E ++
Sbjct: 1507 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1566
Query: 290 SQGPSEEKPAPLATEVFDEKIEVHQ--EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE 347
+ EK A L + +E + V Q EE ER E+ E E + A
Sbjct: 1567 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-AERELERWQLKAN 1625
Query: 348 ELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS 407
E + + + +E K L + E Q + + + K E V + E+
Sbjct: 1626 EALRLRLQAEEVAQQKSLAQ-------AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1678
Query: 408 Q---ERMKVQGSPLKKLFTSTGLKKLSGKKQKG--KRGGGDEESGEHTQVPADSPDSQEE 462
+ +R +G+ ++L L +L + ++G +R +EE + A + +Q+
Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--TQKR 1736
Query: 463 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG---ATSDGEKKREGVTPWASFKKMV 519
Q+ E+ + E+ K AE + +E+ ++ + RE A + +
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1796
Query: 520 TPKKRVRRPSESD---KEDELDKVKSATLSST-ESTASEMQEEMKGSVEEPKPEEPKRKV 575
KR R+ +E D + E ++V + L++ E+T + + E+ +E + E +R
Sbjct: 1797 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1856
Query: 576 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 635
+ + ++R ++ + + +KA ++ +++ G L
Sbjct: 1857 EDE----------AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG----LVEDT 1902
Query: 636 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 695
Q + E E L R ++ L K + + +
Sbjct: 1903 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1962
Query: 696 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 755
+ E + E+ ++K + + +Q +A +E+
Sbjct: 1963 AEEERRRREAEERVQKSLAAEEEA---ARQRKAALEE----------------------- 1996
Query: 756 AVEREKMEAQQAQKSAEQPEQKAATEV-------SKEL-SESQVHMMAAAVADGTRAATI 807
VER K + ++A++ E+ EQ++A ++ K L +E + H A + T+
Sbjct: 1997 -VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2055
Query: 808 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 867
+E+ SV + L + EAEAA E E + E + E E +
Sbjct: 2056 QQEQ-------SVLDQL-RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2107
Query: 868 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 927
+A+ +A AAE +E + AE+ +++
Sbjct: 2108 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA---------------------LRQK 2146
Query: 928 EGGVPDIEEQERRTQEVLQAVAEKVKE----ESQLPGTGGPEDVL-QPVQRAEAERPEEQ 982
+ ++E+ ++ ++ L+ A+ +E QL T +++L + +QR +AE E
Sbjct: 2147 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2206
Query: 983 AEASGLKKETDVVLKVDAQE-----AKTEPFTQGKVV------GQTTPESFEKAPQVTES 1031
+ S +++E V +V +E A+ E + ++ + E EK QV E
Sbjct: 2207 RQRSQVEEELFSV-RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE- 2264
Query: 1032 IESSEL-VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1090
E++ L V +A L + +++ ++A+ ++ + + T K
Sbjct: 2265 -EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-----------ATRLK 2312
Query: 1091 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE---H 1147
E + ++ E+A +A + KE+ + Q+ +E + TLE
Sbjct: 2313 AEAELLQQQKELAQ------EQARRLQEDKEQ-------MAQQLAEETQGFQRTLEAERQ 2359
Query: 1148 TDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALK 1207
E+S E + + A A+E + R++ E+ K
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----------------RKQAEEIGEK 2402
Query: 1208 GEGTEEAECKK---DDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1264
TE A +K LE+Q + RE + ++EREK + + +L+ E
Sbjct: 2403 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ-QEAKLLQLKSEE 2461
Query: 1265 AVTVSEEVSKQLLQ 1278
TV +E QLLQ
Sbjct: 2462 MQTVQQE---QLLQ 2472
Score = 68.6 bits (166), Expect = 5e-11
Identities = 263/1431 (18%), Positives = 535/1431 (37%), Gaps = 181/1431 (12%)
Query: 272 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 331
L+++Y K + ++ + +E++ A + + + + ++ +AE H +
Sbjct: 1315 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1374
Query: 332 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 391
E K + V E +DA+ Q+ +EL +L++ S + ++
Sbjct: 1375 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ--------------SSEAEIQ 1420
Query: 392 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 451
+K + +E L +E ++V +L + + +RGG + E + +
Sbjct: 1421 AKARQAEAAERSRLRIEEEIRV--------------VRLQLEATERQRGGAEGEL-QALR 1465
Query: 452 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTP 511
A+ ++Q+ Q E + + ++ K AEV+ + A + EK+R
Sbjct: 1466 ARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQR----A 1520
Query: 512 WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEP 571
+ +++ + R + + +V+ A ++ S +E+Q + E K +
Sbjct: 1521 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQL 1578
Query: 572 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 631
+R + E + V ++ A R + E + + K E +
Sbjct: 1579 ERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1633
Query: 632 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 691
A + E+ E E ++ ++ V R+ ++ +LE++ + +
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------L 1686
Query: 692 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 751
T E+ + + R + G+Q++ +E+ E + L
Sbjct: 1687 AEGTAQQRLAAEQELIRL-------RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1739
Query: 752 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER 811
A R +ME A K+ + E ++ +E SK+ E++ + R + EE
Sbjct: 1740 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1799
Query: 812 SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA 871
A ++ EAE L + E + T E + +EA + + A
Sbjct: 1800 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK---TEAEIALKEKEAENERLRRLA 1856
Query: 872 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 931
E EA E AA+ ++ ++QL + D + ++ +G V
Sbjct: 1857 E--DEAF----------QRRRLEEQAAQHKADIEERLAQLRKASD-----SELERQKGLV 1899
Query: 932 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGL 988
D Q R+ +E + +A K E G E L + R+ AE R +EQAE
Sbjct: 1900 EDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAA 1956
Query: 989 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTC--QAETL 1046
++ ++ A+E + + +V E E A Q ++E E + +A L
Sbjct: 1957 RQR-----QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRL 2010
Query: 1047 AGVKSQEMVMEQAIPPDSVETPTDSETDG---STPVADFDAPGTTQKDEIVEIHEENEVA 1103
QE + + ++ + +E + + + T Q+++ V + + A
Sbjct: 2011 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV-LDQLRGEA 2069
Query: 1104 SGTQSGGTEAEAVPAQKERPPAPSSFVFQE-ETKEQSKMEDTLEHTDKEVSVETVSILSK 1162
+ EAE Q ER A S +E E +QS E + + E + +
Sbjct: 2070 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL----R 2125
Query: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1222
E QEA + A + + + + ++ +K E L+ + E E L
Sbjct: 2126 KEAEQEAARRAQAEQAALRQKQAADAEME-----KHKKFAEQTLRQKAQVEQEL---TTL 2177
Query: 1223 ELQSHAKSPPSPVEREMVVQVEREKTEA--EPTHVNEEKLEHETAVTVSEEVS--KQLLQ 1278
LQ + E + +++ E TEA + + V EE + EE+S K ++
Sbjct: 2178 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM---EELSKLKARIE 2234
Query: 1279 TVNVPII----DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE----- 1329
N +I D + E + +E A ++ V + EA+ A E+
Sbjct: 2235 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---RLSVAAQEAARLRQLAEEDLAQQR 2291
Query: 1330 ---EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1386
EK+L E ++ L+ A A L+ ++K E ++ A ED K
Sbjct: 2292 ALAEKMLKEKMQAVQEATRLK-AEAELLQQQK--ELAQEQARRLQED----------KEQ 2338
Query: 1387 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1446
A +G LE E+ L+ ++ E++ + ++S A E
Sbjct: 2339 MAQQLAEETQGFQRTLEAERQRQLEMSAEA--ERLKLRVAEMSRA--QARAEEDAQRFRK 2394
Query: 1447 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADS-QDAGQETEKEGEEPQA 1505
++ ++ + + +T + T+E T + T E+Q Q A+ ++A E E+E E+ Q
Sbjct: 2395 QAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2450
Query: 1506 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1565
A K + SE+ TV+ E Q L++ L S
Sbjct: 2451 EA--------------------------KLLQLKSEEMQTVQQEQLLQETQALQQSFL-S 2483
Query: 1566 EEEGGGAGTKSVPEDDG--HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASG 1623
E++ + + ++ L + + K+ +E ++ + E Q +A + +
Sbjct: 2484 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR-LVASMEEAR 2542
Query: 1624 GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQER 1674
E+ + KQ+E + ++ Q+ ++ +E ++ + Q Q L++Q R
Sbjct: 2543 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHR 2592
Score = 52.4 bits (124), Expect = 4e-06
Identities = 179/996 (17%), Positives = 359/996 (36%), Gaps = 124/996 (12%)
Query: 733 AGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVH 792
A PT +E + + + + A+ EK++ Q ++ ++L E+Q
Sbjct: 1045 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1104
Query: 793 MMAAAVADGTRAA-----TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE 847
+ T+A+ E + P++ ++ + L + L + ER+V E
Sbjct: 1105 PATLPELEATKASLKKLRAQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVER 1162
Query: 848 EPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEETTEM 904
V + L + T V + EL + E+A PLGA E+ M
Sbjct: 1163 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1222
Query: 905 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK----VKEESQLPG 960
A SQ E+A ++E+E +EE +R ++ + A+ + V ++QL
Sbjct: 1223 PLADSQAVREQLRQEQAL-LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1279
Query: 961 TGGPEDVLQPVQRAEAERPEEQA--EASGLKKETDVVLKVDAQEAKTEPFT------QGK 1012
E V P ++ + + E E L+ + + +Q K T + +
Sbjct: 1280 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1335
Query: 1013 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1072
+ Q E E+ +V ++E + A+ A + + ++Q + + V
Sbjct: 1336 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR----- 1390
Query: 1073 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1132
D + ++E+ ++ + +E Q+ +AEA + R +
Sbjct: 1391 ---EEAAVDAQQQKRSIQEELQQLRQSSEAE--IQAKARQAEAAERSRLR--------IE 1437
Query: 1133 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDT 1192
EE + + E E ++ ++ E + + A E+ E L +
Sbjct: 1438 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQVQD 1491
Query: 1193 GITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEP 1252
R+ E+A + + EA +K AL+ R + ER +AE
Sbjct: 1492 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--------RLQAEEAERRLRQAEV 1543
Query: 1253 THVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKI 1312
+ ++ ETA +E LQ+ A++ + LE S L +E ++
Sbjct: 1544 ERARQVQVALETAQRSAEAE----LQSKRASF---AEKTAQLERS----LQEEHVAVAQL 1592
Query: 1313 QVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGE 1372
+ EA AE E+ E LE + L L+ + + + A
Sbjct: 1593 R---EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA----- 1644
Query: 1373 DAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI 1432
QA++ A + E + + E+++Q +++ A
Sbjct: 1645 ---------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQ 1692
Query: 1433 EDLEPENGILEL--ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1490
+ L E ++ L ET+ + + +++ + + R AT+ EL+ + ++A+ +
Sbjct: 1693 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK-RQELEAELAKVRAEME 1751
Query: 1491 -----DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSE-ASEKTM 1544
A E E ++ + E +E +E A +A ++ +K + A E
Sbjct: 1752 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1811
Query: 1545 TVEVEGSTVNDQQL-----------EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1593
E V ++L E + E+E + + ED+ A R+E+
Sbjct: 1812 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE--AFQRRRLEEQ 1869
Query: 1594 LVEPKED--------EKGDDVDDPENQNSALADT-DASGGLTKESPDTNGPKQKEKEDAQ 1644
+ K D K D + E Q + DT + +E +K
Sbjct: 1870 AAQHKADIEERLAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1928
Query: 1645 EVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1680
E+EL+ G++ S ++ + + Q EL+ + +E
Sbjct: 1929 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1964
Score = 45.4 bits (106), Expect = 5e-04
Identities = 184/981 (18%), Positives = 369/981 (37%), Gaps = 114/981 (11%)
Query: 24 KEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEE-LTQPTESQANDIGFKKVFKFVG 82
KE ++ + + +D + + EQ ++++EE L Q ++ +++ +K G
Sbjct: 1843 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----G 1897
Query: 83 FKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGD----------HKDPSLGAGEAASKES 132
+ + + + ++L +K + AAG + + + +L + E A E+
Sbjct: 1898 LVEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1955
Query: 133 EPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTS 192
++ EE +RE A +A + K EE E+ +K E+ +
Sbjct: 1956 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERA 2014
Query: 193 ETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEED---GKAEVAS 249
E S + Q A ++ + K V+ E++ +Q ++ + D G+AE A
Sbjct: 2015 EQESARQLQLAQE-AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2073
Query: 250 EKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK 309
+E+A Q E+A R E E+++ +EEQ ++ ++ L E E
Sbjct: 2074 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-ARAQAQAAAEKLRKEAEQEA 2132
Query: 310 IEVHQEEVVAEVHVSTVEERTEEQKTEVEET--AGSVPAEELVEMDAEPQEAEPAKELVK 367
Q E A + E+ K E+T + +EL + + +E + K L+
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2192
Query: 368 LKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS-QERMKVQGSPL-------- 418
+ + E S E+ L V ++E LS + R++ + L
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELF----SVRVQMEELSKLKARIEAENRALILRDKDNT 2248
Query: 419 KKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEI 478
++ K ++ + +E+ Q+ + Q + + +E
Sbjct: 2249 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2308
Query: 479 TCLEKGLAEVQQDGE-AEEGATSDGEKKREGVTPWA----SFKKMVTPKKRVRRPSESDK 533
T L+ +QQ E A+E A E K + A F++ + ++ +R E
Sbjct: 2309 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--QRQLEMSA 2366
Query: 534 EDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKR 593
E E K++ A +S ++ A E + + EE + + T ++ + + + + +
Sbjct: 2367 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR----TELATQEKVTLVQTLEI 2422
Query: 594 ARRGSSSDEEGGPKAMG---GDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAG 650
R+ S D E +A+ + +K + K + ++ + QE + + Q
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE--TQALQQS 2480
Query: 651 SPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK 710
+E + + E F ++ K+KLE+ +D +A + +EE
Sbjct: 2481 FLSEKDSLLQRERF------IEQEKAKLEQLFQDEVA---------KAQQLREEQ----- 2520
Query: 711 KFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKS 770
+R+++ ++ Q V + +++ + V R++ E QQ ++
Sbjct: 2521 -----QRQQQQMEQERQRLVASMEEARRRQHEAE----------EGVRRKQEELQQLEQQ 2565
Query: 771 AEQPEQKAATEVSK-----ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLE 825
Q E+ A E + +L E Q H A A ++ A+ + ++ ++ P
Sbjct: 2566 RRQQEELLAEENQRLREQLQLLEEQ-HRAALAHSEEVTASQVAATKTLPNGRDALDGPAA 2624
Query: 826 QVEAEAALLTEEVLEREVIAEE-EPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETA 884
+ E E + + L R+V A+ + + R A+G T V E + +
Sbjct: 2625 EAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGR 2681
Query: 885 GPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEV 944
+ G A E + +A+ + SP T Q G + D R T
Sbjct: 2682 SSIA---GLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLT--- 2735
Query: 945 LQAVAEKVKEESQLPGTGGPE 965
V E VKE G GPE
Sbjct: 2736 ---VNEAVKE-----GVVGPE 2748
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 73.6 bits (179), Expect = 2e-12
Identities = 228/1214 (18%), Positives = 451/1214 (37%), Gaps = 194/1214 (15%)
Query: 126 EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEE-----KQEKEPS 180
EAA + K+S ++ + L R+ S AEI A +A E + EE + + E +
Sbjct: 1433 EAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1491
Query: 181 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 240
+ + ++ Q + R+ +DE S++K++ E E + +
Sbjct: 1492 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVE-LASR 1547
Query: 241 EDGKAEVASEK-----------LTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 289
+AE A EK L A E AE ++ E + +E ++
Sbjct: 1548 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1607
Query: 290 SQGPSEEKPAPLATEVFDEKIEVHQ--EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE 347
+ EK A L + +E + V Q EE ER E+ E E + A
Sbjct: 1608 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-AERELERWQLKAN 1666
Query: 348 ELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS 407
E + + + +E K L + E Q + + + K E V + E+
Sbjct: 1667 EALRLRLQAEEVAQQKSLAQ-------AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1719
Query: 408 Q---ERMKVQGSPLKKLFTSTGLKKLSGKKQKG--KRGGGDEESGEHTQVPADSPDSQEE 462
+ +R +G+ ++L L +L + ++G +R +EE + A + +Q+
Sbjct: 1720 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--TQKR 1777
Query: 463 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG---ATSDGEKKREGVTPWASFKKMV 519
Q+ E+ + E+ K AE + +E+ ++ + RE A + +
Sbjct: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1837
Query: 520 TPKKRVRRPSESD---KEDELDKVKSATLSST-ESTASEMQEEMKGSVEEPKPEEPKRKV 575
KR R+ +E D + E ++V + L++ E+T + + E+ +E + E +R
Sbjct: 1838 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1897
Query: 576 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 635
+ + ++R ++ + + +KA ++ +++ G L
Sbjct: 1898 EDE----------AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG----LVEDT 1943
Query: 636 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 695
Q + E E L R ++ L K + + +
Sbjct: 1944 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 2003
Query: 696 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 755
+ E + E+ ++K + + +Q +A +E+
Sbjct: 2004 AEEERRRREAEERVQKSLAAEEEA---ARQRKAALEE----------------------- 2037
Query: 756 AVEREKMEAQQAQKSAEQPEQKAATEV-------SKEL-SESQVHMMAAAVADGTRAATI 807
VER K + ++A++ E+ EQ++A ++ K L +E + H A + T+
Sbjct: 2038 -VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2096
Query: 808 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 867
+E+ SV + L + EAEAA E E + E + E E +
Sbjct: 2097 QQEQ-------SVLDQL-RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2148
Query: 868 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 927
+A+ +A AAE +E + AE+ +++
Sbjct: 2149 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA---------------------LRQK 2187
Query: 928 EGGVPDIEEQERRTQEVLQAVAEKVKE----ESQLPGTGGPEDVL-QPVQRAEAERPEEQ 982
+ ++E+ ++ ++ L+ A+ +E QL T +++L + +QR +AE E
Sbjct: 2188 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2247
Query: 983 AEASGLKKETDVVLKVDAQE-----AKTEPFTQGKVV------GQTTPESFEKAPQVTES 1031
+ S +++E V +V +E A+ E + ++ + E EK QV E
Sbjct: 2248 RQRSQVEEELFSV-RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE- 2305
Query: 1032 IESSEL-VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1090
E++ L V +A L + +++ ++A+ ++ + + T K
Sbjct: 2306 -EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-----------ATRLK 2353
Query: 1091 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE---H 1147
E + ++ E+A +A + KE+ + Q+ +E + TLE
Sbjct: 2354 AEAELLQQQKELAQ------EQARRLQEDKEQ-------MAQQLAEETQGFQRTLEAERQ 2400
Query: 1148 TDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALK 1207
E+S E + + A A+E + R++ E+ K
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----------------RKQAEEIGEK 2443
Query: 1208 GEGTEEAECKK---DDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1264
TE A +K LE+Q + RE + ++EREK + + +L+ E
Sbjct: 2444 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ-QEAKLLQLKSEE 2502
Query: 1265 AVTVSEEVSKQLLQ 1278
TV +E QLLQ
Sbjct: 2503 MQTVQQE---QLLQ 2513
Score = 68.6 bits (166), Expect = 5e-11
Identities = 263/1431 (18%), Positives = 535/1431 (37%), Gaps = 181/1431 (12%)
Query: 272 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 331
L+++Y K + ++ + +E++ A + + + + ++ +AE H +
Sbjct: 1356 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1415
Query: 332 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 391
E K + V E +DA+ Q+ +EL +L++ S + ++
Sbjct: 1416 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ--------------SSEAEIQ 1461
Query: 392 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 451
+K + +E L +E ++V +L + + +RGG + E + +
Sbjct: 1462 AKARQAEAAERSRLRIEEEIRV--------------VRLQLEATERQRGGAEGEL-QALR 1506
Query: 452 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTP 511
A+ ++Q+ Q E + + ++ K AEV+ + A + EK+R
Sbjct: 1507 ARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQR----A 1561
Query: 512 WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEP 571
+ +++ + R + + +V+ A ++ S +E+Q + E K +
Sbjct: 1562 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQL 1619
Query: 572 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 631
+R + E + V ++ A R + E + + K E +
Sbjct: 1620 ERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1674
Query: 632 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 691
A + E+ E E ++ ++ V R+ ++ +LE++ + +
Sbjct: 1675 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------L 1727
Query: 692 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 751
T E+ + + R + G+Q++ +E+ E + L
Sbjct: 1728 AEGTAQQRLAAEQELIRL-------RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1780
Query: 752 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER 811
A R +ME A K+ + E ++ +E SK+ E++ + R + EE
Sbjct: 1781 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1840
Query: 812 SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA 871
A ++ EAE L + E + T E + +EA + + A
Sbjct: 1841 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK---TEAEIALKEKEAENERLRRLA 1897
Query: 872 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 931
E EA E AA+ ++ ++QL + D + ++ +G V
Sbjct: 1898 E--DEAF----------QRRRLEEQAAQHKADIEERLAQLRKASD-----SELERQKGLV 1940
Query: 932 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGL 988
D Q R+ +E + +A K E G E L + R+ AE R +EQAE
Sbjct: 1941 EDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAA 1997
Query: 989 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTC--QAETL 1046
++ ++ A+E + + +V E E A Q ++E E + +A L
Sbjct: 1998 RQR-----QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRL 2051
Query: 1047 AGVKSQEMVMEQAIPPDSVETPTDSETDG---STPVADFDAPGTTQKDEIVEIHEENEVA 1103
QE + + ++ + +E + + + T Q+++ V + + A
Sbjct: 2052 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV-LDQLRGEA 2110
Query: 1104 SGTQSGGTEAEAVPAQKERPPAPSSFVFQE-ETKEQSKMEDTLEHTDKEVSVETVSILSK 1162
+ EAE Q ER A S +E E +QS E + + E + +
Sbjct: 2111 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL----R 2166
Query: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1222
E QEA + A + + + + ++ +K E L+ + E E L
Sbjct: 2167 KEAEQEAARRAQAEQAALRQKQAADAEME-----KHKKFAEQTLRQKAQVEQEL---TTL 2218
Query: 1223 ELQSHAKSPPSPVEREMVVQVEREKTEA--EPTHVNEEKLEHETAVTVSEEVS--KQLLQ 1278
LQ + E + +++ E TEA + + V EE + EE+S K ++
Sbjct: 2219 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM---EELSKLKARIE 2275
Query: 1279 TVNVPII----DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE----- 1329
N +I D + E + +E A ++ V + EA+ A E+
Sbjct: 2276 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---RLSVAAQEAARLRQLAEEDLAQQR 2332
Query: 1330 ---EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1386
EK+L E ++ L+ A A L+ ++K E ++ A ED K
Sbjct: 2333 ALAEKMLKEKMQAVQEATRLK-AEAELLQQQK--ELAQEQARRLQED----------KEQ 2379
Query: 1387 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1446
A +G LE E+ L+ ++ E++ + ++S A E
Sbjct: 2380 MAQQLAEETQGFQRTLEAERQRQLEMSAEA--ERLKLRVAEMSRA--QARAEEDAQRFRK 2435
Query: 1447 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADS-QDAGQETEKEGEEPQA 1505
++ ++ + + +T + T+E T + T E+Q Q A+ ++A E E+E E+ Q
Sbjct: 2436 QAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2491
Query: 1506 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1565
A K + SE+ TV+ E Q L++ L S
Sbjct: 2492 EA--------------------------KLLQLKSEEMQTVQQEQLLQETQALQQSFL-S 2524
Query: 1566 EEEGGGAGTKSVPEDDG--HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASG 1623
E++ + + ++ L + + K+ +E ++ + E Q +A + +
Sbjct: 2525 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR-LVASMEEAR 2583
Query: 1624 GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQER 1674
E+ + KQ+E + ++ Q+ ++ +E ++ + Q Q L++Q R
Sbjct: 2584 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHR 2633
Score = 52.4 bits (124), Expect = 4e-06
Identities = 179/996 (17%), Positives = 359/996 (36%), Gaps = 124/996 (12%)
Query: 733 AGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVH 792
A PT +E + + + + A+ EK++ Q ++ ++L E+Q
Sbjct: 1086 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1145
Query: 793 MMAAAVADGTRAA-----TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE 847
+ T+A+ E + P++ ++ + L + L + ER+V E
Sbjct: 1146 PATLPELEATKASLKKLRAQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVER 1203
Query: 848 EPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEETTEM 904
V + L + T V + EL + E+A PLGA E+ M
Sbjct: 1204 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1263
Query: 905 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK----VKEESQLPG 960
A SQ E+A ++E+E +EE +R ++ + A+ + V ++QL
Sbjct: 1264 PLADSQAVREQLRQEQAL-LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1320
Query: 961 TGGPEDVLQPVQRAEAERPEEQA--EASGLKKETDVVLKVDAQEAKTEPFT------QGK 1012
E V P ++ + + E E L+ + + +Q K T + +
Sbjct: 1321 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376
Query: 1013 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1072
+ Q E E+ +V ++E + A+ A + + ++Q + + V
Sbjct: 1377 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR----- 1431
Query: 1073 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1132
D + ++E+ ++ + +E Q+ +AEA + R +
Sbjct: 1432 ---EEAAVDAQQQKRSIQEELQQLRQSSEAE--IQAKARQAEAAERSRLR--------IE 1478
Query: 1133 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDT 1192
EE + + E E ++ ++ E + + A E+ E L +
Sbjct: 1479 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQVQD 1532
Query: 1193 GITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEP 1252
R+ E+A + + EA +K AL+ R + ER +AE
Sbjct: 1533 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--------RLQAEEAERRLRQAEV 1584
Query: 1253 THVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKI 1312
+ ++ ETA +E LQ+ A++ + LE S L +E ++
Sbjct: 1585 ERARQVQVALETAQRSAEAE----LQSKRASF---AEKTAQLERS----LQEEHVAVAQL 1633
Query: 1313 QVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGE 1372
+ EA AE E+ E LE + L L+ + + + A
Sbjct: 1634 R---EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA----- 1685
Query: 1373 DAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI 1432
QA++ A + E + + E+++Q +++ A
Sbjct: 1686 ---------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQ 1733
Query: 1433 EDLEPENGILEL--ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1490
+ L E ++ L ET+ + + +++ + + R AT+ EL+ + ++A+ +
Sbjct: 1734 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK-RQELEAELAKVRAEME 1792
Query: 1491 -----DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSE-ASEKTM 1544
A E E ++ + E +E +E A +A ++ +K + A E
Sbjct: 1793 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1852
Query: 1545 TVEVEGSTVNDQQL-----------EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1593
E V ++L E + E+E + + ED+ A R+E+
Sbjct: 1853 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE--AFQRRRLEEQ 1910
Query: 1594 LVEPKED--------EKGDDVDDPENQNSALADT-DASGGLTKESPDTNGPKQKEKEDAQ 1644
+ K D K D + E Q + DT + +E +K
Sbjct: 1911 AAQHKADIEERLAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969
Query: 1645 EVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1680
E+EL+ G++ S ++ + + Q EL+ + +E
Sbjct: 1970 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2005
Score = 45.4 bits (106), Expect = 5e-04
Identities = 184/981 (18%), Positives = 369/981 (37%), Gaps = 114/981 (11%)
Query: 24 KEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEE-LTQPTESQANDIGFKKVFKFVG 82
KE ++ + + +D + + EQ ++++EE L Q ++ +++ +K G
Sbjct: 1884 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----G 1938
Query: 83 FKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGD----------HKDPSLGAGEAASKES 132
+ + + + ++L +K + AAG + + + +L + E A E+
Sbjct: 1939 LVEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1996
Query: 133 EPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTS 192
++ EE +RE A +A + K EE E+ +K E+ +
Sbjct: 1997 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERA 2055
Query: 193 ETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEED---GKAEVAS 249
E S + Q A ++ + K V+ E++ +Q ++ + D G+AE A
Sbjct: 2056 EQESARQLQLAQE-AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2114
Query: 250 EKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK 309
+E+A Q E+A R E E+++ +EEQ ++ ++ L E E
Sbjct: 2115 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-ARAQAQAAAEKLRKEAEQEA 2173
Query: 310 IEVHQEEVVAEVHVSTVEERTEEQKTEVEET--AGSVPAEELVEMDAEPQEAEPAKELVK 367
Q E A + E+ K E+T + +EL + + +E + K L+
Sbjct: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
Query: 368 LKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS-QERMKVQGSPL-------- 418
+ + E S E+ L V ++E LS + R++ + L
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELF----SVRVQMEELSKLKARIEAENRALILRDKDNT 2289
Query: 419 KKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEI 478
++ K ++ + +E+ Q+ + Q + + +E
Sbjct: 2290 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2349
Query: 479 TCLEKGLAEVQQDGE-AEEGATSDGEKKREGVTPWA----SFKKMVTPKKRVRRPSESDK 533
T L+ +QQ E A+E A E K + A F++ + ++ +R E
Sbjct: 2350 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--QRQLEMSA 2407
Query: 534 EDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKR 593
E E K++ A +S ++ A E + + EE + + T ++ + + + + +
Sbjct: 2408 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR----TELATQEKVTLVQTLEI 2463
Query: 594 ARRGSSSDEEGGPKAMG---GDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAG 650
R+ S D E +A+ + +K + K + ++ + QE + + Q
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE--TQALQQS 2521
Query: 651 SPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK 710
+E + + E F ++ K+KLE+ +D +A + +EE
Sbjct: 2522 FLSEKDSLLQRERF------IEQEKAKLEQLFQDEVA---------KAQQLREEQ----- 2561
Query: 711 KFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKS 770
+R+++ ++ Q V + +++ + V R++ E QQ ++
Sbjct: 2562 -----QRQQQQMEQERQRLVASMEEARRRQHEAE----------EGVRRKQEELQQLEQQ 2606
Query: 771 AEQPEQKAATEVSK-----ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLE 825
Q E+ A E + +L E Q H A A ++ A+ + ++ ++ P
Sbjct: 2607 RRQQEELLAEENQRLREQLQLLEEQ-HRAALAHSEEVTASQVAATKTLPNGRDALDGPAA 2665
Query: 826 QVEAEAALLTEEVLEREVIAEE-EPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETA 884
+ E E + + L R+V A+ + + R A+G T V E + +
Sbjct: 2666 EAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGR 2722
Query: 885 GPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEV 944
+ G A E + +A+ + SP T Q G + D R T
Sbjct: 2723 SSIA---GLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLT--- 2776
Query: 945 LQAVAEKVKEESQLPGTGGPE 965
V E VKE G GPE
Sbjct: 2777 ---VNEAVKE-----GVVGPE 2789
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.298 0.119 0.311
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,346,277
Number of Sequences: 37866
Number of extensions: 3735173
Number of successful extensions: 26308
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 168
Number of HSP's successfully gapped in prelim test: 1449
Number of HSP's that attempted gapping in prelim test: 13505
Number of HSP's gapped (non-prelim): 9215
length of query: 1684
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1568
effective length of database: 13,855,062
effective search space: 21724737216
effective search space used: 21724737216
T: 11
A: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 44 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.