Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 21396500
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21396500 HIRA interacting protein 3 [Homo sapiens]
(556 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21396500 HIRA interacting protein 3 [Homo sapiens] 1097 0.0
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 87 4e-17
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 84 4e-16
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 80 6e-15
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 80 6e-15
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 80 6e-15
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 78 2e-14
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 78 2e-14
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 78 2e-14
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 76 9e-14
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 72 1e-12
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 72 1e-12
gi|50962882 G patch domain containing 8 [Homo sapiens] 71 2e-12
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 70 4e-12
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 70 5e-12
gi|221219020 NYD-SP11 protein [Homo sapiens] 70 7e-12
gi|87299628 biorientation of chromosomes in cell division 1-like... 69 9e-12
gi|68299795 chromodomain helicase DNA binding protein 1 [Homo sa... 69 9e-12
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 69 1e-11
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 69 1e-11
gi|217330641 IWS1 homolog [Homo sapiens] 69 1e-11
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 69 1e-11
gi|210032580 SET domain containing 1B [Homo sapiens] 69 1e-11
gi|157738619 smoothelin-like 1 [Homo sapiens] 69 1e-11
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 68 2e-11
gi|221316599 chromogranin B precursor [Homo sapiens] 68 3e-11
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 68 3e-11
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 68 3e-11
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 68 3e-11
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 67 3e-11
>gi|21396500 HIRA interacting protein 3 [Homo sapiens]
Length = 556
Score = 1097 bits (2838), Expect = 0.0
Identities = 556/556 (100%), Positives = 556/556 (100%)
Query: 1 MAREKEMQEFTRSFFRGRPDLSTLTHSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLK 60
MAREKEMQEFTRSFFRGRPDLSTLTHSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLK
Sbjct: 1 MAREKEMQEFTRSFFRGRPDLSTLTHSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLK 60
Query: 61 MQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGV 120
MQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGV
Sbjct: 61 MQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGV 120
Query: 121 AAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQ 180
AAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQ
Sbjct: 121 AAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQ 180
Query: 181 APGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQRE 240
APGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQRE
Sbjct: 181 APGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQRE 240
Query: 241 EEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAAS 300
EEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAAS
Sbjct: 241 EEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAAS 300
Query: 301 SGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSG 360
SGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSG
Sbjct: 301 SGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSG 360
Query: 361 EESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRG 420
EESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRG
Sbjct: 361 EESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRG 420
Query: 421 EDHPAVMRLKRYIRACGAHRNYKKLLGSCCSHKERLSILRAELEALGMKGTPSLGKCRAL 480
EDHPAVMRLKRYIRACGAHRNYKKLLGSCCSHKERLSILRAELEALGMKGTPSLGKCRAL
Sbjct: 421 EDHPAVMRLKRYIRACGAHRNYKKLLGSCCSHKERLSILRAELEALGMKGTPSLGKCRAL 480
Query: 481 KEQREEAAEVASLDVANIISGSGRPRRRTAWNPLGEAAPPGELYRRTLDSDEERPRPAPP 540
KEQREEAAEVASLDVANIISGSGRPRRRTAWNPLGEAAPPGELYRRTLDSDEERPRPAPP
Sbjct: 481 KEQREEAAEVASLDVANIISGSGRPRRRTAWNPLGEAAPPGELYRRTLDSDEERPRPAPP 540
Query: 541 DWSHMRGIISSDGESN 556
DWSHMRGIISSDGESN
Sbjct: 541 DWSHMRGIISSDGESN 556
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 87.0 bits (214), Expect = 4e-17
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 12/304 (3%)
Query: 119 GVAAEVSPAKEENPRRASKAVEE-SSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVV 177
G A V A++ R EE SS E +D ++GE+ E G+ K+ +
Sbjct: 639 GKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKE-LA 697
Query: 178 KKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKE 237
+K+ K ++ +E + + E Q + E G +E ++E EEE + KE
Sbjct: 698 EKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKE 757
Query: 238 QREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKE 297
E E EE E E ++E+G+ K R+ K EE + + + + G + +EE E
Sbjct: 758 --EGEGEEVEGEREKEEGERKKEERAGKEEKG--EEEGDQGEGEEEETEGRGEEKEEGGE 813
Query: 298 AASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGS 357
+ G+ + + E + G+ G E+EE GKGE + G
Sbjct: 814 VEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGE-----GE 868
Query: 358 TSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSG 417
GEE + E E + E G +GE + ++ +G + E KG + G
Sbjct: 869 EEGEEGEGEGEEEEGEGEGEEEGEGEG-EEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEE 927
Query: 418 RRGE 421
GE
Sbjct: 928 GEGE 931
Score = 85.9 bits (211), Expect = 9e-17
Identities = 88/391 (22%), Positives = 150/391 (38%), Gaps = 43/391 (10%)
Query: 37 SGRSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRF 96
SG H + EE++ + E K + + E + +L +K + + E+K
Sbjct: 664 SGAEHWQDEERE------KGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQ 717
Query: 97 NSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRG 156
+ E E G ++G E +EE + + EE EE + + + G
Sbjct: 718 GHQKERNQEMEE----GGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEG 773
Query: 157 EESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKG 216
E EE GK K Q G+ + + E+ E E E +VE KG
Sbjct: 774 ERKKEERA----GKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVE-----GGEVEEGKG 824
Query: 217 TKSLKESEQESEEEILAQKKEQREEEVEEEEK--EEDEEKGDWKPRTRSN---GRRKSAR 271
+ +E E E EEE ++E+ E E EE E EE+ E+G+ + G +
Sbjct: 825 EREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGE 884
Query: 272 EERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSG 331
E + + + + G+ + EEE + + G+ E + + E + G+ G
Sbjct: 885 GEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDG 944
Query: 332 SSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSS 391
E EE+ G+ E GEE + E E + G G +GE + ++
Sbjct: 945 EGEGEEEEGEWE----------------GEEEEGEGEGEEEGEGEGEEGEGE---GEEEE 985
Query: 392 RKGRTRSSSSSSDGSPEAKGGKAGSGRRGED 422
+G +G E +G + G G E+
Sbjct: 986 GEGEGEEEEGEEEGEEEGEGEEEGEGEGEEE 1016
Score = 83.2 bits (204), Expect = 6e-16
Identities = 96/427 (22%), Positives = 163/427 (38%), Gaps = 48/427 (11%)
Query: 26 HSIVRRRYLAHSGRS-HLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPT 84
H R + + G H E EE++ + EE+ E +E+ +G+R
Sbjct: 719 HQKERNQEMEEGGEEEHGEGEEEEGDREEEEEK-------EGEGKEEGEGEEVEGEREK- 770
Query: 85 PCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSD 144
+ ERK+ + E G E G E KEE VEE
Sbjct: 771 --EEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEE----KEEGGEVEGGEVEEGKG 824
Query: 145 EERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPV 204
E + + + EE E EE+ +G+ + + G+ + EE EE E E
Sbjct: 825 EREEEEEEGEGEEEEGEGEEEEGEGEEEEG-----EGKGEEEGEEGEGEEEGEEGEGEGE 879
Query: 205 QRTAKKV--EGNKGTKSLKESEQESEEEILAQKKEQR-----EEEVEEEEKEEDEEKGDW 257
+ + E +G +E E E EEE + +E+ EEE EE E E +EE+G+
Sbjct: 880 EEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEG 939
Query: 258 KPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKS 317
+ +G + EE + + + G+ + E E +E G++ + E +
Sbjct: 940 EGE---DGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGE 996
Query: 318 EDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGG 377
E+ + G+ +EE+ G+ E +G GEE ERE + G G
Sbjct: 997 EEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEERE----KEGEG 1052
Query: 378 PQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGEDHPAVMRLKRYIRACG 437
+ R R +G + G + + GE++ V ++K ++ G
Sbjct: 1053 EENR-------------RNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVK-YG 1098
Query: 438 AHRNYKK 444
H+ Y+K
Sbjct: 1099 KHKTYQK 1105
Score = 80.1 bits (196), Expect = 5e-15
Identities = 65/295 (22%), Positives = 125/295 (42%), Gaps = 15/295 (5%)
Query: 140 EESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEES 199
+E +++ + + Q E++EE K + G+ K ++ KA VS +A+ E
Sbjct: 590 KEGAEDSKGNGIEEQE-VEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAE 648
Query: 200 EAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKP 259
+ + EG+ G + ++ E+E E+ + + +R E E+E E++E K
Sbjct: 649 DGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGE 708
Query: 260 RTRSNGRRKSAREERSCKQKSQAKRLLGDSDSE----EEQKEAASSGDDSGRDREPPVQR 315
R + ++ER+ + + + G+ + E EE++E G + G E +R
Sbjct: 709 EQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGER 768
Query: 316 KSED---RTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSG---EESDLEREV 369
+ E+ + + + GK G E ++ G+ E T + G G EE ERE
Sbjct: 769 EKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREE 828
Query: 370 SDSEAGGGP---QGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGE 421
+ E G +GE + ++ +G+ +G E + G+ G G E
Sbjct: 829 EEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGE-GEGEEEE 882
Score = 59.7 bits (143), Expect = 7e-09
Identities = 64/258 (24%), Positives = 108/258 (41%), Gaps = 11/258 (4%)
Query: 99 ESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDE--ERQRDLPAQRG 156
E E E + G + G E +EE + + EE E E + + + G
Sbjct: 888 EEEGEGEGEEEEGEGEGEEEG---EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDG 944
Query: 157 EESSEEEEKGYKGKTRK-KPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNK 215
E EEEE ++G+ + + +++ G+ + EE E E E + + E +
Sbjct: 945 EGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGE 1004
Query: 216 GTKSLK-ESEQESEEEILAQ-KKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREE 273
G + + E E+E E E+ + + E+ E E EEEE EE+ E+ + + N R + EE
Sbjct: 1005 GEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEE 1064
Query: 274 RSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSS 333
K + + D EE +K + G + Q+KS TQ G ++ S
Sbjct: 1065 EEGKYQETGEEENERQDGEEYKKVSKIKGSVK-YGKHKTYQKKSVTNTQGNGKEQRSKMP 1123
Query: 334 EDEEDSGKGEPTAKGSRK 351
+ K P+ GS+K
Sbjct: 1124 VQSKRLLKNGPS--GSKK 1139
Score = 48.5 bits (114), Expect = 2e-05
Identities = 62/317 (19%), Positives = 127/317 (40%), Gaps = 50/317 (15%)
Query: 118 NGVAAEVSPAKEENPRRA------SKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKT 171
N + ++SP +++ ++ A+ E+ D + ++ + ++ ++ +G
Sbjct: 511 NEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVS--QGIF 568
Query: 172 RKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEI 231
+P +A V + +E +E+S+ ++ ++VE N+ + +E E +
Sbjct: 569 MTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEE--QEVEANEENVKVHGGRKEKTEIL 626
Query: 232 ---LAQKKEQREEEVEEEEKEED--EEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLL 286
L K E E + + + ED E +GD S+G EER +K + +
Sbjct: 627 SDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGR--- 683
Query: 287 GDSDSEEE-QKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPT 345
G+ + E +KE A + RD E Q++ E Q + + + E+E G+ E
Sbjct: 684 GEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEE-- 741
Query: 346 AKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDG 405
+G R+ EE + E E + G +GER+ ++ +
Sbjct: 742 -EGDRE---------EEEEKEGEGKEEGEGEEVEGEREKEEGERKKEE------------ 779
Query: 406 SPEAKGGKAGSGRRGED 422
+AG +GE+
Sbjct: 780 -------RAGKEEKGEE 789
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 83.6 bits (205), Expect = 4e-16
Identities = 83/344 (24%), Positives = 149/344 (43%), Gaps = 25/344 (7%)
Query: 69 REDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAK 128
RE + D K+ +R D +R++ R N + E E G + E
Sbjct: 95 RERQRDREKERERQTDRERDRQREKER-NRQKERERETEREGERGRDRQTDGQRE----- 148
Query: 129 EENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVS 188
E R A K E +D ERQR R +E E E+ + + R++ K+
Sbjct: 149 RERQRDAEKERERQTDRERQRQTERNRQKER-EREKNRQERRERERQREKENKTEDRHSE 207
Query: 189 RKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEK 248
R + RE E+E E ++ E ++ K+ +E E+++E E ++++ +R++E E E+
Sbjct: 208 RGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKE-RERER 266
Query: 249 EEDEEKG-DWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGR 307
+ D ++ K R R R++ R ER + + + +R + E E++ + R
Sbjct: 267 DRDRDRDRRQKERERQTDRKRQRRTERDRETERKRER---QRERERERERNRKRERERER 323
Query: 308 DREPPVQRKSE-DRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLE 366
+RE QR++E DR + + KR + E D + T + R+ A E + E
Sbjct: 324 ERERERQRETERDREKERERKR---KRQTEMDRERNRQTGREGRRQA--------ERERE 372
Query: 367 REVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAK 410
RE + + + E + R + +K R R + DG E +
Sbjct: 373 RE-RERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETE 415
Score = 79.0 bits (193), Expect = 1e-14
Identities = 84/378 (22%), Positives = 162/378 (42%), Gaps = 32/378 (8%)
Query: 38 GRSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFN 97
GR +++ ++ E+ + Q D R+ + + K+ +R ER+R R
Sbjct: 138 GRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQR-- 195
Query: 98 SESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQR-- 155
E E+ +E D + + + E R+ + + ER+R+ A+R
Sbjct: 196 -EKENKTE----DRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERER 250
Query: 156 -GEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGN 214
E +E +++ + + R + ++Q + RK+ R + E E + ++ E
Sbjct: 251 ASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERE 310
Query: 215 KGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREER 274
+ +E E+E E E Q++ +R+ E E E K + + + D + R R GR + ER
Sbjct: 311 RERNRKRERERERERERERQRETERDREKERERKRKRQTEMD-RERNRQTGREGRRQAER 369
Query: 275 SCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSE 334
+++ + R S E E++E D RDR+ +R++E + G+R +E
Sbjct: 370 ERERERERDR---QSAREREERER-----DRDRDRQKERERQTEKD---RDGQR---ETE 415
Query: 335 DEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKG 394
+ + K + +G + G E D ER+ +D +A G ++ RS+ +
Sbjct: 416 KQREREKDRESERGRERGREREKQKGRERDRERQ-TDRQA-----GRQRKRSTLYVNPPP 469
Query: 395 RT-RSSSSSSDGSPEAKG 411
RT RS SD + +G
Sbjct: 470 RTARSGVVQSDPNRPTRG 487
Score = 68.2 bits (165), Expect = 2e-11
Identities = 62/274 (22%), Positives = 120/274 (43%), Gaps = 20/274 (7%)
Query: 126 PAKEENPRRA------SKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKK 179
P +E+PRR A + + RQ++ +R + +E E + + R+K +K
Sbjct: 31 PGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRK 90
Query: 180 QAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQR 239
+ + R++ RE+ E + + + ++ E N+ + +E+E+E E Q QR
Sbjct: 91 RDRHR---ERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQR 147
Query: 240 EEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAA 299
E E + + ++E E + D + R R R + ER ++ + +R + +KE
Sbjct: 148 ERERQRDAEKERERQTD-RERQRQTERNRQKEREREKNRQERRER------ERQREKENK 200
Query: 300 SSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTS 359
+ S R RE +R++E T+ KR + D + + E + R+ A T
Sbjct: 201 TEDRHSERGRERERERETETETE---RKRQTDRERDRQRKTEREREKQAERERASERETE 257
Query: 360 GEESDLEREVSDSEAGGGPQGERKNRSSKKSSRK 393
+ + ERE Q ER+ ++ +K R+
Sbjct: 258 -RDKERERERDRDRDRDRRQKERERQTDRKRQRR 290
Score = 65.9 bits (159), Expect = 1e-10
Identities = 55/306 (17%), Positives = 120/306 (39%), Gaps = 16/306 (5%)
Query: 115 PAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKK 174
P + G+ A ++ R + E E+RQ + R E E+++ K ++
Sbjct: 37 PRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRE 96
Query: 175 PVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQ 234
++ + R++ R+ +E + + + EG +G + ++E E + A+
Sbjct: 97 RQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAE 156
Query: 235 KKEQREEEVEEE-------EKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLG 287
K+ +R+ + E + +KE + EK + R R R K + E ++ + +
Sbjct: 157 KERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERER 216
Query: 288 DSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAK 347
++++E E+K D RDR+ +R+ E + + + + E + + +
Sbjct: 217 ETETETERKRQT----DRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDR 272
Query: 348 GSRKMARLGSTSGE-----ESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSS 402
R+ R T + E D E E + +NR ++ + R R
Sbjct: 273 DRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRE 332
Query: 403 SDGSPE 408
++ E
Sbjct: 333 TERDRE 338
Score = 45.4 bits (106), Expect = 1e-04
Identities = 38/204 (18%), Positives = 81/204 (39%), Gaps = 5/204 (2%)
Query: 193 REESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDE 252
R S+ES A K + ++ E+E E K++ E + E+ ++
Sbjct: 30 RPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRRE----KRQTERETDRKRERRREK 85
Query: 253 EKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPP 312
++ + R R R + ER ++ +R + +E ++E G + GRDR+
Sbjct: 86 DRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREG-ERGRDRQTD 144
Query: 313 VQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDS 372
QR+ E + + + E + + + + K + + + E + D
Sbjct: 145 GQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDR 204
Query: 373 EAGGGPQGERKNRSSKKSSRKGRT 396
+ G + ER+ + ++ RK +T
Sbjct: 205 HSERGRERERERETETETERKRQT 228
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 79.7 bits (195), Expect = 6e-15
Identities = 60/224 (26%), Positives = 106/224 (47%), Gaps = 9/224 (4%)
Query: 114 PPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRK 173
P + G +E+ + E R E S+ +++R +R E E+E K +GK K
Sbjct: 28 PCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKRER-EKERKRERGKKEK 86
Query: 174 KPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILA 233
K KK+ RK+ R E E E E ++ KK + +G S + E+E +EE
Sbjct: 87 KGERKKEER-----ERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKR 141
Query: 234 QKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEE 293
+++++RE + EE EKE E K K + G ++ R+E+ K++ + +R + E
Sbjct: 142 EERKERERKKEEREKER-ERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKER 200
Query: 294 EQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEE 337
E+KE + + E +R+ + +T + +R G E +E
Sbjct: 201 ERKERRERKKERKKKEERKKERQKDRQTNWREKER--GKRERKE 242
Score = 65.9 bits (159), Expect = 1e-10
Identities = 51/219 (23%), Positives = 98/219 (44%), Gaps = 15/219 (6%)
Query: 204 VQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRS 263
++ +++E K K +ESE++ E ++K +RE+E + E+ + E+KG+ K R
Sbjct: 38 IREREREIETRKEGKKERESERKKERREREKRKREREKE-RKRERGKKEKKGERKKEERE 96
Query: 264 NGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQL 323
+R+ +E + ++K + K+ +E+KE + + G++RE +RK E+R +
Sbjct: 97 RKKRRREKENKEGEEKEKRKK--------KEKKERGRTSKE-GKERERKEERKREERKER 147
Query: 324 KGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERK 383
+ K + ++ K E G ++ R E ER + + + ERK
Sbjct: 148 ERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERK----KERERK 203
Query: 384 NRSSKKSSRKGR-TRSSSSSSDGSPEAKGGKAGSGRRGE 421
R +K RK + R D + + G R E
Sbjct: 204 ERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKE 242
Score = 63.2 bits (152), Expect = 6e-10
Identities = 54/225 (24%), Positives = 107/225 (47%), Gaps = 17/225 (7%)
Query: 160 SEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKS 219
SE E+ + +TRK+ ++++ RK+ R E E+ + E + +K E K K
Sbjct: 36 SEIREREREIETRKEGKKERES------ERKKERREREKRKRE--REKERKRERGKKEKK 87
Query: 220 LKESEQESEEEILAQKKEQRE-EEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQ 278
+ ++E E + ++KE +E EE E+ +K+E +E+G RT G+ + +EER ++
Sbjct: 88 GERKKEERERKKRRREKENKEGEEKEKRKKKEKKERG----RTSKEGKERERKEERKREE 143
Query: 279 KSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEED 338
+ + +R + + E E+KE ++E +RK ++R + K KR E +++
Sbjct: 144 RKERERKKEEREKERERKERKKRERKQVGEKEE--ERKEKERKERK--KRERNRKERKKE 199
Query: 339 SGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERK 383
+ E + + + + D + + E G + ERK
Sbjct: 200 RERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERK 244
Score = 63.2 bits (152), Expect = 6e-10
Identities = 58/235 (24%), Positives = 104/235 (44%), Gaps = 40/235 (17%)
Query: 38 GRSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFN 97
G+ E E K+ + E E K + ++ RE + KKG+R +R+R + N
Sbjct: 51 GKKERESERKKERR---EREKRKREREKERKRE-RGKKEKKGERKKEERERKKRRREKEN 106
Query: 98 SESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGE 157
E E + + K+E R + + E EER+R+ +R E
Sbjct: 107 KEGEEKEKRKKKE-----------------KKERGRTSKEGKERERKEERKREERKER-E 148
Query: 158 ESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGT 217
EE EK + K RKK RKQ E+ EE + E ++ KK E N+
Sbjct: 149 RKKEEREKERERKERKKR------------ERKQVGEKEEERK-EKERKERKKRERNR-- 193
Query: 218 KSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSARE 272
KE ++E E + ++K++R+++ E +++ + + + +W+ + R RK ++
Sbjct: 194 ---KERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 60.1 bits (144), Expect = 5e-09
Identities = 56/238 (23%), Positives = 100/238 (42%), Gaps = 25/238 (10%)
Query: 182 PGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREE 241
PG S R++ RE E + + + +K E + K +E E+E + E KKE++
Sbjct: 32 PGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRE--RGKKEKKG- 88
Query: 242 EVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASS 301
E +KEE E K + + G K R+++ K++ + + E E+KE
Sbjct: 89 ---ERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSK----EGKERERKEERKR 141
Query: 302 GDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGE 361
+ R+R+ + K +R + K +R ++EE K RK + + +
Sbjct: 142 EERKERERKKEEREKERERKERKKRERKQVGEKEEERKEK-------ERKERKKRERNRK 194
Query: 362 ESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRR 419
E ERE + + ERK KK RK + R ++ + +G + R+
Sbjct: 195 ERKKERERKE-------RRERKKERKKKEERK-KERQKDRQTNWREKERGKRERKERK 244
Score = 37.4 bits (85), Expect = 0.036
Identities = 35/174 (20%), Positives = 67/174 (38%), Gaps = 9/174 (5%)
Query: 257 WKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRK 316
W+ R R R+E +++S+ K+ + + + ++E + ++++ +RK
Sbjct: 34 WQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKG--ERK 91
Query: 317 SEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGG 376
E+R + K + E E G+ + K K R G TS E + ER+
Sbjct: 92 KEERERKKRRR------EKENKEGEEKEKRKKKEKKER-GRTSKEGKERERKEERKREER 144
Query: 377 GPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGEDHPAVMRLK 430
+ +K K+ RK R + E + K R+ + R K
Sbjct: 145 KERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKK 198
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 79.7 bits (195), Expect = 6e-15
Identities = 69/274 (25%), Positives = 129/274 (47%), Gaps = 12/274 (4%)
Query: 43 EPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKK--GKRPPTPCSDPERKRFRFNSES 100
+PE + A K L+EE + DE S +D+ + KK GK+ D E K + NSES
Sbjct: 1228 DPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKN-QVNSES 1286
Query: 101 ESGSEASS-PDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEES 159
+S SE S P Y ++ + + EE + +K E + R R + E
Sbjct: 1287 DSDSEESKKPRYRHRLLRHKLTVSDGESGEE---KKTKPKEHKEVKGRNRRKVSSEDSED 1343
Query: 160 SEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKS 219
S+ +E G + + +Q P S ++K EE++ S + +R KV+ + +++
Sbjct: 1344 SDFQESGVSEEVSESE--DEQRPRTRS-AKKAELEENQRSYKQKKKRRRIKVQEDSSSEN 1400
Query: 220 LKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREE--RSCK 277
SE+E EE+ +++E+ EEE EE+E ++ + G + + R + R E + K
Sbjct: 1401 KSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALK 1460
Query: 278 QKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREP 311
++ + ++ + + + E E+ +D+ + P
Sbjct: 1461 EEEERRKRIAEREREREKLREVIEIEDASPTKCP 1494
Score = 70.5 bits (171), Expect = 4e-12
Identities = 61/280 (21%), Positives = 115/280 (41%), Gaps = 49/280 (17%)
Query: 129 EENPRRASKAVEES-SDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASV 187
EE +R K EE+ DEE + + ++ +S E ++ Y+ + + +
Sbjct: 1259 EEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDG------ 1312
Query: 188 SRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEE 247
E EE + +P + K+V+G K E ++S+ + E V EE
Sbjct: 1313 ------ESGEEKKTKPKEH--KEVKGRNRRKVSSEDSEDSDFQ---------ESGVSEEV 1355
Query: 248 KEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGR 307
E ++E+ +PRTRS + + +RS KQK + +R+ DS E K + ++
Sbjct: 1356 SESEDEQ---RPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKE 1412
Query: 308 DREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLER 367
+ E + + E+ EDE D K KG +K+ ++ ++ +
Sbjct: 1413 EEEEEEEEEEEE-------------EEDENDDSKS--PGKGRKKIRKILKDDKLRTETQN 1457
Query: 368 EVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSP 407
+ + E ER+ R +++ + + R D SP
Sbjct: 1458 ALKEEE-------ERRKRIAEREREREKLREVIEIEDASP 1490
Score = 51.6 bits (122), Expect = 2e-06
Identities = 85/414 (20%), Positives = 154/414 (37%), Gaps = 51/414 (12%)
Query: 46 EKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSE 105
+K+ +K + E ++ RE+ K K+ +D E+K + ++ +
Sbjct: 961 KKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKD 1020
Query: 106 ASSPDYFGPPAKNGVAAEVSPAKE--------ENPR-----RASKAVEESSDEERQRDLP 152
S DY G + + S K+ E R ++S+ ++ S + ++
Sbjct: 1021 ELS-DYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSM 1079
Query: 153 AQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKK-- 210
+ G SS++ K + + R+ K+ S S EES E + QRT+ K
Sbjct: 1080 KEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKK 1139
Query: 211 --VEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRS----- 263
+ K SL+ S + + +I + E++ + E ++ KP T +
Sbjct: 1140 AVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSS 1199
Query: 264 -NGRRKSAREERSCKQKSQAKRLLGDSDSE------------EEQKEAASSGDDSGRDRE 310
G +S+ +E KS + D D EE K SS +D D E
Sbjct: 1200 HTGFCQSSGDE--ALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDE 1257
Query: 311 PP--VQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLERE 368
P +R + + G + E DS E +K R RL L +
Sbjct: 1258 PEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEE--SKKPRYRHRL---------LRHK 1306
Query: 369 VSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGED 422
++ S+ G + + K + K+ + R + SS S+ S + G + ED
Sbjct: 1307 LTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESED 1360
Score = 50.4 bits (119), Expect = 4e-06
Identities = 84/396 (21%), Positives = 161/396 (40%), Gaps = 36/396 (9%)
Query: 128 KEENPRRASKAVEESSDEERQRDLPAQ-----RGEESSEEEEKGYKGKTRKKPVVKKQAP 182
K++ +R K+ SD + ++ A+ + + ++ E Y + K+ +K +
Sbjct: 735 KDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKE--IKSMSK 792
Query: 183 GKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEE 242
A+ + K+ +++ ++ ++ +KK N+G K+LK S++ S ++ A++K++RE
Sbjct: 793 IGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDD--AERKQERETF 850
Query: 243 VEEEEKEEDE----EKGDWKPRTRSNGRRKSAREERSCKQKS-QAKRLLGDSDSEEEQKE 297
E + + E D P+ + ++ S K++S + + ++++E+ K
Sbjct: 851 SSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKH 910
Query: 298 AASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKG----SRKMA 353
+ +D + K LK + S +D++ S KG K +K+
Sbjct: 911 LKTKTCKKVQDGLSDIAEKF-----LKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVI 965
Query: 354 RL-----GSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGS-- 406
++ S+ G E ERE G Q + +K S+K R ++S + S
Sbjct: 966 KMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDY 1025
Query: 407 PEAKGGKAGSGRRGEDHPAVMRLKRYIRACGAHRNYKKLLGSCCSHKERLSILRAELEAL 466
E GK S ED K A G + KLLG ++ S E ++
Sbjct: 1026 AEKSTGKGDSCDSSEDK------KSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSM 1079
Query: 467 GMKGTPSLGKCRALKEQREEAAEVASLDVANIISGS 502
G S K E RE + + I SGS
Sbjct: 1080 KEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGS 1115
Score = 50.1 bits (118), Expect = 5e-06
Identities = 67/305 (21%), Positives = 125/305 (40%), Gaps = 39/305 (12%)
Query: 128 KEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASV 187
K++ ++ V++ S +E+ R ++E+ K K KT KK + +
Sbjct: 872 KKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFL 931
Query: 188 SRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEE 247
+ Q+ E SE+ + + + T +K + + K + + EQ+ E +K EE+
Sbjct: 932 KKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFP 991
Query: 248 KEEDEEKGDWKPRTRSNGRRKSAR-EERSCKQKSQ----AKRLLGDSDSEEEQKEAASSG 302
K + K ++G +KS + +++ K+K + A++ G DS + ++ S
Sbjct: 992 KGIKQIKNG-----TTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKN 1046
Query: 303 DDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEE 362
GR++ K K L SS +D + T K S K S+
Sbjct: 1047 GAYGREK--------------KRCKLLGKSSRKRQDCSSSD-TEKYSMKEDGCNSSDKRL 1091
Query: 363 SDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGED 422
+E ER+N SSK+++++ +S SSSSD ++ K R
Sbjct: 1092 KRIELR------------ERRNLSSKRNTKE--IQSGSSSSDAEESSEDNKKKKQRTSSK 1137
Query: 423 HPAVM 427
AV+
Sbjct: 1138 KKAVI 1142
Score = 34.7 bits (78), Expect = 0.24
Identities = 40/205 (19%), Positives = 72/205 (35%), Gaps = 11/205 (5%)
Query: 227 SEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLL 286
S+EE KE+++ V +K++ + N KS + E + Q S + +L
Sbjct: 639 SDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSE-TVDQNSDSDEML 697
Query: 287 GDSDSEEEQKEAASSGDDSGRDR-------EPPVQRKSEDRTQLKGGKRLSGSSEDEEDS 339
++SS D + Q +D+ + K SGS D +
Sbjct: 698 AILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKG 757
Query: 340 GKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERK---NRSSKKSSRKGRT 396
+ + +K +S +S+LE+E+ G + +K N SS +
Sbjct: 758 KSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKH 817
Query: 397 RSSSSSSDGSPEAKGGKAGSGRRGE 421
+ G K + GS E
Sbjct: 818 SKKGMDNQGHKNLKTSQEGSSDDAE 842
Score = 31.2 bits (69), Expect = 2.6
Identities = 65/317 (20%), Positives = 114/317 (35%), Gaps = 35/317 (11%)
Query: 74 DLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGP-PAKNGVAAEVSPAKEENP 132
++ KK K+ ++ +F ++ SE SS A V A++
Sbjct: 313 EMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADI-------- 364
Query: 133 RRASKAVEESSDEERQRDLPAQRGEESSEEE---EKGYKGKTRK--KPVV---KKQAPGK 184
++A A+EE + E R + A E++++E + ++ K RK KP K + +
Sbjct: 365 KKAHLALEEDLNSEF-RAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSE 423
Query: 185 ASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEE---------EILAQK 235
A +SRKQ E ++ K G + KS ++ E + E +I++
Sbjct: 424 AKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVP 483
Query: 236 KEQREE-----EVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSD 290
E+ E E + + +GD T S + S K +
Sbjct: 484 SSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGG---IKSKT 540
Query: 291 SEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSR 350
+ + KE P ++ Q K G + G + E G G+ +
Sbjct: 541 TAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEH 600
Query: 351 KMARLGSTSGEESDLER 367
+ S EESDL R
Sbjct: 601 LVENEVSLLLEESDLRR 617
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 79.7 bits (195), Expect = 6e-15
Identities = 69/274 (25%), Positives = 129/274 (47%), Gaps = 12/274 (4%)
Query: 43 EPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKK--GKRPPTPCSDPERKRFRFNSES 100
+PE + A K L+EE + DE S +D+ + KK GK+ D E K + NSES
Sbjct: 1266 DPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKN-QVNSES 1324
Query: 101 ESGSEASS-PDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEES 159
+S SE S P Y ++ + + EE + +K E + R R + E
Sbjct: 1325 DSDSEESKKPRYRHRLLRHKLTVSDGESGEE---KKTKPKEHKEVKGRNRRKVSSEDSED 1381
Query: 160 SEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKS 219
S+ +E G + + +Q P S ++K EE++ S + +R KV+ + +++
Sbjct: 1382 SDFQESGVSEEVSESE--DEQRPRTRS-AKKAELEENQRSYKQKKKRRRIKVQEDSSSEN 1438
Query: 220 LKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREE--RSCK 277
SE+E EE+ +++E+ EEE EE+E ++ + G + + R + R E + K
Sbjct: 1439 KSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALK 1498
Query: 278 QKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREP 311
++ + ++ + + + E E+ +D+ + P
Sbjct: 1499 EEEERRKRIAEREREREKLREVIEIEDASPTKCP 1532
Score = 70.5 bits (171), Expect = 4e-12
Identities = 61/280 (21%), Positives = 115/280 (41%), Gaps = 49/280 (17%)
Query: 129 EENPRRASKAVEES-SDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASV 187
EE +R K EE+ DEE + + ++ +S E ++ Y+ + + +
Sbjct: 1297 EEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDG------ 1350
Query: 188 SRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEE 247
E EE + +P + K+V+G K E ++S+ + E V EE
Sbjct: 1351 ------ESGEEKKTKPKEH--KEVKGRNRRKVSSEDSEDSDFQ---------ESGVSEEV 1393
Query: 248 KEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGR 307
E ++E+ +PRTRS + + +RS KQK + +R+ DS E K + ++
Sbjct: 1394 SESEDEQ---RPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKE 1450
Query: 308 DREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLER 367
+ E + + E+ EDE D K KG +K+ ++ ++ +
Sbjct: 1451 EEEEEEEEEEEE-------------EEDENDDSKS--PGKGRKKIRKILKDDKLRTETQN 1495
Query: 368 EVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSP 407
+ + E ER+ R +++ + + R D SP
Sbjct: 1496 ALKEEE-------ERRKRIAEREREREKLREVIEIEDASP 1528
Score = 51.6 bits (122), Expect = 2e-06
Identities = 85/414 (20%), Positives = 154/414 (37%), Gaps = 51/414 (12%)
Query: 46 EKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSE 105
+K+ +K + E ++ RE+ K K+ +D E+K + ++ +
Sbjct: 999 KKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKD 1058
Query: 106 ASSPDYFGPPAKNGVAAEVSPAKE--------ENPR-----RASKAVEESSDEERQRDLP 152
S DY G + + S K+ E R ++S+ ++ S + ++
Sbjct: 1059 ELS-DYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSM 1117
Query: 153 AQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKK-- 210
+ G SS++ K + + R+ K+ S S EES E + QRT+ K
Sbjct: 1118 KEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKK 1177
Query: 211 --VEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRS----- 263
+ K SL+ S + + +I + E++ + E ++ KP T +
Sbjct: 1178 AVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSS 1237
Query: 264 -NGRRKSAREERSCKQKSQAKRLLGDSDSE------------EEQKEAASSGDDSGRDRE 310
G +S+ +E KS + D D EE K SS +D D E
Sbjct: 1238 HTGFCQSSGDE--ALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDE 1295
Query: 311 PP--VQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLERE 368
P +R + + G + E DS E +K R RL L +
Sbjct: 1296 PEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEE--SKKPRYRHRL---------LRHK 1344
Query: 369 VSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGED 422
++ S+ G + + K + K+ + R + SS S+ S + G + ED
Sbjct: 1345 LTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESED 1398
Score = 50.4 bits (119), Expect = 4e-06
Identities = 84/396 (21%), Positives = 161/396 (40%), Gaps = 36/396 (9%)
Query: 128 KEENPRRASKAVEESSDEERQRDLPAQ-----RGEESSEEEEKGYKGKTRKKPVVKKQAP 182
K++ +R K+ SD + ++ A+ + + ++ E Y + K+ +K +
Sbjct: 773 KDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKE--IKSMSK 830
Query: 183 GKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEE 242
A+ + K+ +++ ++ ++ +KK N+G K+LK S++ S ++ A++K++RE
Sbjct: 831 IGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDD--AERKQERETF 888
Query: 243 VEEEEKEEDE----EKGDWKPRTRSNGRRKSAREERSCKQKS-QAKRLLGDSDSEEEQKE 297
E + + E D P+ + ++ S K++S + + ++++E+ K
Sbjct: 889 SSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKH 948
Query: 298 AASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKG----SRKMA 353
+ +D + K LK + S +D++ S KG K +K+
Sbjct: 949 LKTKTCKKVQDGLSDIAEKF-----LKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVI 1003
Query: 354 RL-----GSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGS-- 406
++ S+ G E ERE G Q + +K S+K R ++S + S
Sbjct: 1004 KMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDY 1063
Query: 407 PEAKGGKAGSGRRGEDHPAVMRLKRYIRACGAHRNYKKLLGSCCSHKERLSILRAELEAL 466
E GK S ED K A G + KLLG ++ S E ++
Sbjct: 1064 AEKSTGKGDSCDSSEDK------KSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSM 1117
Query: 467 GMKGTPSLGKCRALKEQREEAAEVASLDVANIISGS 502
G S K E RE + + I SGS
Sbjct: 1118 KEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGS 1153
Score = 50.1 bits (118), Expect = 5e-06
Identities = 67/305 (21%), Positives = 125/305 (40%), Gaps = 39/305 (12%)
Query: 128 KEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASV 187
K++ ++ V++ S +E+ R ++E+ K K KT KK + +
Sbjct: 910 KKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFL 969
Query: 188 SRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEE 247
+ Q+ E SE+ + + + T +K + + K + + EQ+ E +K EE+
Sbjct: 970 KKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFP 1029
Query: 248 KEEDEEKGDWKPRTRSNGRRKSAR-EERSCKQKSQ----AKRLLGDSDSEEEQKEAASSG 302
K + K ++G +KS + +++ K+K + A++ G DS + ++ S
Sbjct: 1030 KGIKQIKNG-----TTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKN 1084
Query: 303 DDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEE 362
GR++ K K L SS +D + T K S K S+
Sbjct: 1085 GAYGREK--------------KRCKLLGKSSRKRQDCSSSD-TEKYSMKEDGCNSSDKRL 1129
Query: 363 SDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGED 422
+E ER+N SSK+++++ +S SSSSD ++ K R
Sbjct: 1130 KRIELR------------ERRNLSSKRNTKE--IQSGSSSSDAEESSEDNKKKKQRTSSK 1175
Query: 423 HPAVM 427
AV+
Sbjct: 1176 KKAVI 1180
Score = 34.7 bits (78), Expect = 0.24
Identities = 40/205 (19%), Positives = 72/205 (35%), Gaps = 11/205 (5%)
Query: 227 SEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLL 286
S+EE KE+++ V +K++ + N KS + E + Q S + +L
Sbjct: 677 SDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSE-TVDQNSDSDEML 735
Query: 287 GDSDSEEEQKEAASSGDDSGRDR-------EPPVQRKSEDRTQLKGGKRLSGSSEDEEDS 339
++SS D + Q +D+ + K SGS D +
Sbjct: 736 AILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKG 795
Query: 340 GKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERK---NRSSKKSSRKGRT 396
+ + +K +S +S+LE+E+ G + +K N SS +
Sbjct: 796 KSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKH 855
Query: 397 RSSSSSSDGSPEAKGGKAGSGRRGE 421
+ G K + GS E
Sbjct: 856 SKKGMDNQGHKNLKTSQEGSSDDAE 880
Score = 31.2 bits (69), Expect = 2.6
Identities = 65/317 (20%), Positives = 114/317 (35%), Gaps = 35/317 (11%)
Query: 74 DLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGP-PAKNGVAAEVSPAKEENP 132
++ KK K+ ++ +F ++ SE SS A V A++
Sbjct: 351 EMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADI-------- 402
Query: 133 RRASKAVEESSDEERQRDLPAQRGEESSEEE---EKGYKGKTRK--KPVV---KKQAPGK 184
++A A+EE + E R + A E++++E + ++ K RK KP K + +
Sbjct: 403 KKAHLALEEDLNSEF-RAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSE 461
Query: 185 ASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEE---------EILAQK 235
A +SRKQ E ++ K G + KS ++ E + E +I++
Sbjct: 462 AKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVP 521
Query: 236 KEQREE-----EVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSD 290
E+ E E + + +GD T S + S K +
Sbjct: 522 SSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGG---IKSKT 578
Query: 291 SEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSR 350
+ + KE P ++ Q K G + G + E G G+ +
Sbjct: 579 TAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEH 638
Query: 351 KMARLGSTSGEESDLER 367
+ S EESDL R
Sbjct: 639 LVENEVSLLLEESDLRR 655
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 78.2 bits (191), Expect = 2e-14
Identities = 84/375 (22%), Positives = 154/375 (41%), Gaps = 23/375 (6%)
Query: 43 EPEEKQALKRLVEEELLKMQV-DEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESE 101
E EE ++ + E K +EA S + K+ + P PE+ + E++
Sbjct: 534 EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 593
Query: 102 SGSEASSPDYFGPPAK---NGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEE 158
S +EA SP+ P K A SP KEE A E + + + + +
Sbjct: 594 SPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAK 653
Query: 159 SSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKG-- 216
S E+EE K + + ++P KA S +A +S E PV+ AK E K
Sbjct: 654 SPEKEEAKSPEKAKSPVKAEAKSPEKAK-SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPV 712
Query: 217 ---TKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRT---RSNGRRKSA 270
KS ++++ +EE A+ E+ + V+EE K ++ K K +T +S + A
Sbjct: 713 KEEAKSPEKAKSPVKEE--AKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPA 770
Query: 271 REE-RSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRL 329
+EE RS K K + + ++A S + + E + +K E ++ +K
Sbjct: 771 KEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVK----- 825
Query: 330 SGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKK 389
E ++ EP K + A + E+ D ++E + + P+ E K + +
Sbjct: 826 --EEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
Query: 390 SSRKGRTRSSSSSSD 404
++ + + ++
Sbjct: 884 KPKESKVEAKKEEAE 898
Score = 75.1 bits (183), Expect = 2e-13
Identities = 99/440 (22%), Positives = 177/440 (40%), Gaps = 64/440 (14%)
Query: 39 RSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNS 98
+S + E K + E+ +EA S + K+ + P PE+ +
Sbjct: 585 KSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE 644
Query: 99 ESESGSEASSPD----YFGPPAKNGVAAEV-------SPAKEE--NPRRASKAVEESSDE 145
E++S +A SP+ AK+ V AE SP K E +P +A V+E +
Sbjct: 645 EAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKS 704
Query: 146 ERQRDLPAQRGEESSEEEEKGYKGKTR-----KKPV-------VKKQAPGKA---SVSRK 190
+ P + +S E+ + K + + K PV K ++P KA V
Sbjct: 705 PEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSP 764
Query: 191 QAREESEESEAEPVQRTAKKVEG---------NKGTKSLKESEQESEEEILAQKKEQREE 241
+A+ ++E P + +K + K LKE + E+EI KKE+ +
Sbjct: 765 EAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEI--PKKEEVKS 822
Query: 242 EVEEEEKEE-----------DEEKGDWKPRT--RSNGRRKSAREERSCKQKSQAKRLLG- 287
V+EEEK + +EEK P+T + + +++ A ++ + K K + K+
Sbjct: 823 PVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAV 882
Query: 288 ----DSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGE 343
+S E +++EA ++E P K E + K ++ + ++ +D+ E
Sbjct: 883 EKPKESKVEAKKEEAEDKKKVPTPEKEAPA--KVEVKEDAKPKEKTEVAKKEPDDAKAKE 940
Query: 344 PTAKGSRKMA--RLGSTSGEESDLEREVSDSEAGGGPQGERKNRS-SKKSSRKGRTRSSS 400
P+ +K A T E++ E +EA + ++ SK + K SS+
Sbjct: 941 PSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSST 1000
Query: 401 SSSDGSPEAKG--GKAGSGR 418
D P K KA G+
Sbjct: 1001 DQKDSKPPEKATEDKAAKGK 1020
Score = 62.0 bits (149), Expect = 1e-09
Identities = 70/302 (23%), Positives = 125/302 (41%), Gaps = 13/302 (4%)
Query: 113 GPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTR 172
G P V+ + EE + K+ +E+ E Q + Q EE +EEEEK K +
Sbjct: 425 GLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTE-ETQVTEEVTEEEEKEAKEEEG 483
Query: 173 KKPV--VKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEE 230
K+ +++A G ++ EE+ E E ++ + KS ++ E +S E
Sbjct: 484 KEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAE 543
Query: 231 ILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSD 290
+ + E+ + +EE K E K K +S KS + +S K +AK ++
Sbjct: 544 V--KSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKS-PAKEEAKS-PAEAK 599
Query: 291 SEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSR 350
S E+ K S + + PV+ +++ ++K ++ +++E S P S
Sbjct: 600 SPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKS----PEKAKSP 655
Query: 351 KMARLGSTSGEESDLEREVSDSEAGGGP-QGERKNRSSKKSSRKGRTRS-SSSSSDGSPE 408
+ S +S ++ E E P + E K+ KS K +S + S E
Sbjct: 656 EKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 715
Query: 409 AK 410
AK
Sbjct: 716 AK 717
Score = 60.5 bits (145), Expect = 4e-09
Identities = 68/304 (22%), Positives = 116/304 (38%), Gaps = 26/304 (8%)
Query: 123 EVSPAKEENPRRASKAVEESSD--EERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKK- 179
E AKEE + EE ++ EE + PA+ S E+E K + K P K
Sbjct: 474 EEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEA-ASPEKEAKSPVKEEAKSPAEAKS 532
Query: 180 ------QAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGT------KSLKESEQES 227
++P + K EE+++ P ++ +K E K+ +++E+
Sbjct: 533 PEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 592
Query: 228 EEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLG 287
+ A+ E+ + V+EE K E K K +S KS + +S ++
Sbjct: 593 KSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKA 652
Query: 288 DSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAK 347
S +EE K + + + P + KS + + K ++ ++E S P
Sbjct: 653 KSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKS----PEKA 708
Query: 348 GSRKMARLGSTSGEESDLEREVSDSEAGGGP-QGERKNRSSKKSSRKGRTRSSSSSSDGS 406
S S +S ++ E E P + E K+ KS K +T S
Sbjct: 709 KSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVK-----S 763
Query: 407 PEAK 410
PEAK
Sbjct: 764 PEAK 767
Score = 58.2 bits (139), Expect = 2e-08
Identities = 68/286 (23%), Positives = 117/286 (40%), Gaps = 16/286 (5%)
Query: 129 EENPRRASKAVEESSDEERQRDLPAQRGEESSEEEE-KGYKGKTRKKPVVKKQAPGKASV 187
EE E + +EE++ + EE EEEE +G + +T+ P + +P K +
Sbjct: 458 EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEA- 516
Query: 188 SRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEE 247
K +E +S AE ++ + KS ++++ ++EE A+ + + +EE
Sbjct: 517 --KSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE--AKSPPEAKSPEKEEA 572
Query: 248 KEEDEEKGDWKPRTRSNGRRKSAREERSC-KQKSQAKRLLGDSDSEEEQKEAASSGDDSG 306
K E K K ++ + KS E +S K KS K ++ S E K S
Sbjct: 573 KSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKE---EAKSPAEAKSPVKEEAKSP 629
Query: 307 RDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLE 366
+ + P + KS + + K ++ ++E S P S A S +S ++
Sbjct: 630 AEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKS----PEKAKSPVKAEAKSPEKAKSPVK 685
Query: 367 REVSDSEAGGGP-QGERKNRSSKKSSRKGRTRS-SSSSSDGSPEAK 410
E E P + E K+ KS K +S + S EAK
Sbjct: 686 AEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK 731
Score = 51.6 bits (122), Expect = 2e-06
Identities = 56/229 (24%), Positives = 108/229 (47%), Gaps = 19/229 (8%)
Query: 198 ESEAEPVQRTAKK-VEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGD 256
E + + V+++ K+ V + T+ + +E+ +EEE +KE +EEE +EEE E+EE
Sbjct: 441 EEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEE----EKEAKEEEGKEEEGGEEEEAEG 496
Query: 257 WKPRTRSNGRRKSAREERSCKQ--KSQAKRLLGDSDSEEEQKEAASSGDD--SGRDREPP 312
+ T+S ++A E+ K K +AK ++++ +KE A S + S + P
Sbjct: 497 GEEETKSPPAEEAASPEKEAKSPVKEEAK---SPAEAKSPEKEEAKSPAEVKSPEKAKSP 553
Query: 313 VQRKSEDRTQLKGGKRLSGSSEDEEDSGK--GEPTAKGSRKMARLGSTSGEESDLEREV- 369
+ +++ + K ++ S E S + P + ++ A S +S ++ E
Sbjct: 554 AKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK 613
Query: 370 SDSEAGGGPQGERKNRSSKKSSRKGRT----RSSSSSSDGSPEAKGGKA 414
S +EA + E K+ + KS K ++ + S SPE + K+
Sbjct: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKS 662
Score = 30.4 bits (67), Expect = 4.4
Identities = 63/313 (20%), Positives = 113/313 (36%), Gaps = 71/313 (22%)
Query: 226 ESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRL 285
+SEE+I +K ++E + EE+ EE +
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQ--------------------------------- 465
Query: 286 LGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPT 345
+ + +EEE+KEA ++ G++ E + ++E GG+ + S EE + E
Sbjct: 466 VTEEVTEEEEKEAK---EEEGKEEEGGEEEEAE------GGEEETKSPPAEE-AASPEKE 515
Query: 346 AKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDG 405
AK K E S +EA + E K+ + KS K + S
Sbjct: 516 AKSPVK--------------EEAKSPAEAKSPEKEEAKSPAEVKSPEKAK-------SPA 554
Query: 406 SPEAKGGKAGSGRRGEDHPAVMRLKRYIRACGAHRNYKKLLGSCCSHKERLSILRAELEA 465
EAK E+ + +K +A + K S ++ S ++ E ++
Sbjct: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS 614
Query: 466 LGMKGTPSLGKCRALKEQREEAAEVASLDVANIISGSGRPRRRTAWNPLGEAAPPGELYR 525
+P +KE+ + AEV S + A + A +P E A E +
Sbjct: 615 PAEAKSP-------VKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAK 667
Query: 526 RTLDSDEERPRPA 538
+ ++ + P A
Sbjct: 668 SPVKAEAKSPEKA 680
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 77.8 bits (190), Expect = 2e-14
Identities = 80/336 (23%), Positives = 151/336 (44%), Gaps = 34/336 (10%)
Query: 120 VAAEVSPAKEENPRRA--SKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVV 177
+++++ K E P+ K VEE +E + D E SE EE T + V
Sbjct: 432 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVED-------EKSEMEE-ALTAITEELAVS 483
Query: 178 KKQAPGKASVSRKQAREESEESEA---EPVQRTAKKVEGNKGTKSLKESEQESEEEILAQ 234
K+ +A+ +++ E EE A PV+ TA +V+ +G K +E ++E EEE
Sbjct: 484 MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGA 543
Query: 235 KKEQREEEVEEEEKEEDEEKG---DWKPRTRSNGRRKSAREERSCKQKSQ----AKRLLG 287
K +Q EE E+E ++E+G + + + G A+EE+ ++KS+ + L+
Sbjct: 544 KSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVA 603
Query: 288 DSDSEEEQKEAA----SSGDDSGRDREP--PVQRKSED---RTQLKGGKRLSGSSEDEED 338
D+ E+ +K + S ++ G+ P PV+ K + ++ ++ + E+
Sbjct: 604 DAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE 663
Query: 339 SGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRS 398
GK P +K + + +S +E S +E G G Q E + + K++ ++ +
Sbjct: 664 KGK-SPVSKS--PVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEK 720
Query: 399 SSSSSDGSPEAKGGKAGSGRRGEDHPAVMRLKRYIR 434
PE K KA S + E V+ + + ++
Sbjct: 721 KEEKPKDVPEKK--KAESPVKEEAVAEVVTITKSVK 754
Score = 61.2 bits (147), Expect = 2e-09
Identities = 80/332 (24%), Positives = 131/332 (39%), Gaps = 61/332 (18%)
Query: 54 VEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFG 113
V+EE + + +E E++ D K + S+ E + E E G + +
Sbjct: 520 VKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEE 579
Query: 114 PPAKNGVAAE------------VSPAKEENPRRASKAVEESSDEERQRD-LPAQRGEESS 160
AK E V+ AK E P +A V +S EE+ + +P EE
Sbjct: 580 AEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKG 639
Query: 161 EE-------EEKGY----------KGKT----------RKKPVVK---KQAPGKASVSRK 190
+ EEKG KGK+ K PV K ++A KA V +
Sbjct: 640 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKG 699
Query: 191 QAREESEES--EAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQK---KEQREEEVEE 245
+ +EE E+ EA ++ KK E K K++E +EE +A+ + + +E+
Sbjct: 700 EQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEK 759
Query: 246 EEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAK-------RLLGDSDSEEEQKEA 298
E KEE + K + ++ G S E K K + G + E+E KE
Sbjct: 760 ETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEK 819
Query: 299 ASSGDD------SGRDREPPVQRKSEDRTQLK 324
S ++ +G D P ++K D+++ K
Sbjct: 820 GSGREEEKGVVTNGLDLSPADEKKGGDKSEEK 851
Score = 59.3 bits (142), Expect = 9e-09
Identities = 88/393 (22%), Positives = 148/393 (37%), Gaps = 50/393 (12%)
Query: 45 EEKQALKRLVEEELLKMQVDEAASREDKLDLTKK------GKRPPTPCSDPERKRFRFNS 98
E ++AL + EE + M+ ++ + E+K + + K+ P + PE K
Sbjct: 468 EMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEK 527
Query: 99 ESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEE 158
E E G E + G AK+ A E KE S EE EE + + A+ GEE
Sbjct: 528 EEEEGQEEEEEEDEG--AKSDQAEEGGSEKE-----GSSEKEEGEQEEGETEAEAE-GEE 579
Query: 159 SSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEE-SEAEPVQRTAKKVEGNKGT 217
+ +EEK + E+SEE + E + AK + K
Sbjct: 580 AEAKEEK-------------------------KVEEKSEEVATKEELVADAKVEKPEKAK 614
Query: 218 KSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCK 277
+ +S E + + K E+ K EEKG P +S K
Sbjct: 615 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK-SPVPKSPVEEKGKSPVSKSP 673
Query: 278 QKSQAKRLLGDSDSEEEQKEA-ASSGDDSGRDREPPVQRKSEDRTQLKGGK------RLS 330
+ +AK + S EE + +A G+ + + + E++ + K K +
Sbjct: 674 VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKK 733
Query: 331 GSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAG--GGPQGERKNRSSK 388
S +E++ T S K+ T E L++E +AG GG + E ++ +K
Sbjct: 734 AESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAK 793
Query: 389 KSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGE 421
S ++ + E + + GSGR E
Sbjct: 794 GSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 826
Score = 54.7 bits (130), Expect = 2e-07
Identities = 62/328 (18%), Positives = 129/328 (39%), Gaps = 21/328 (6%)
Query: 116 AKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKP 175
A + E++ + +E + A++ EE + E + + +++ E K +G+ ++
Sbjct: 472 ALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEE 531
Query: 176 VVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQK 235
+++ QA E E E + ++ EG ++ E + EE+ + +K
Sbjct: 532 GQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEK 591
Query: 236 KEQ---REEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQA---------- 282
E+ +EE V + + E+ E+ P++ + KS + ++K ++
Sbjct: 592 SEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 651
Query: 283 -KRLLGDSDSEEEQKEAASSGDDSGRDREP-PVQRKSEDRTQLKGGKRLSGSSEDEE--D 338
K + S EE+ K S + + P P E +++ + GK E++E +
Sbjct: 652 GKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKE 711
Query: 339 SGKGEPTAKGSRKMARLGSTSGEESDLER----EVSDSEAGGGPQGERKNRSSKKSSRKG 394
+ K E K K + ES ++ EV E++ + K ++
Sbjct: 712 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 771
Query: 395 RTRSSSSSSDGSPEAKGGKAGSGRRGED 422
+ + + GS E K G R ED
Sbjct: 772 KEKEKAGGEGGSEEEGSDKGAKGSRKED 799
Score = 53.1 bits (126), Expect = 6e-07
Identities = 80/287 (27%), Positives = 125/287 (43%), Gaps = 45/287 (15%)
Query: 38 GRSHLEPEEKQALKRLVEEELLKMQVDEAASRED-----KLDLTKKGKRPPTPCSDPERK 92
G + E E ++A + EE+ ++ + +E A++E+ K++ +K K P P S E K
Sbjct: 569 GETEAEAEGEEAEAK--EEKKVEEKSEEVATKEELVADAKVEKPEKAKSP-VPKSPVEEK 625
Query: 93 RFRFNSESESGSEASSPDYFGPPAKNGVA-AEVSPAKEENPRRASKA---------VEES 142
+S + SP P + G + SP +E+ SK+ V +S
Sbjct: 626 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKS 685
Query: 143 SDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREE-SEESEA 201
EE + +GE+ EEEEK K +++ V KK+ K +K+A EE+ A
Sbjct: 686 PVEEAKSKAEVGKGEQK-EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVA 744
Query: 202 EPVQRTAK-KVEGNKGTKSL-KESEQESEEEILAQK------------KEQREEEV---- 243
E V T KV K TK K +QE E+E + K R+E++
Sbjct: 745 EVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNG 804
Query: 244 EEEEKEEDE----EKGDWKPRTR---SNGRRKSAREERSCKQKSQAK 283
E E KEE E EKG + + +NG S +E+ KS+ K
Sbjct: 805 EVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEK 851
Score = 32.0 bits (71), Expect = 1.5
Identities = 51/198 (25%), Positives = 72/198 (36%), Gaps = 38/198 (19%)
Query: 34 LAHSGRSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKR 93
+ S + HLE E K+ K L +E+ + E S E+ D KG R ++
Sbjct: 749 ITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR---------KED 799
Query: 94 FRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDL-P 152
N E E E ++E + S EE DL P
Sbjct: 800 IAVNGEVEGKEE---------------------VEQETKEKGSGREEEKGVVTNGLDLSP 838
Query: 153 AQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKA-----SVSRKQAREESEESEAEPVQRT 207
A + + EEK KT +K + + G SV+ Q EE EE+ E + T
Sbjct: 839 ADEKKGGDKSEEKVVVTKTVEK-ITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVST 897
Query: 208 AKKVEGNKGTKSLKESEQ 225
KKVE +KE Q
Sbjct: 898 -KKVEKVTSHAIVKEVTQ 914
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 77.8 bits (190), Expect = 2e-14
Identities = 80/336 (23%), Positives = 151/336 (44%), Gaps = 34/336 (10%)
Query: 120 VAAEVSPAKEENPRRA--SKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVV 177
+++++ K E P+ K VEE +E + D E SE EE T + V
Sbjct: 56 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVED-------EKSEMEE-ALTAITEELAVS 107
Query: 178 KKQAPGKASVSRKQAREESEESEA---EPVQRTAKKVEGNKGTKSLKESEQESEEEILAQ 234
K+ +A+ +++ E EE A PV+ TA +V+ +G K +E ++E EEE
Sbjct: 108 MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGA 167
Query: 235 KKEQREEEVEEEEKEEDEEKG---DWKPRTRSNGRRKSAREERSCKQKSQ----AKRLLG 287
K +Q EE E+E ++E+G + + + G A+EE+ ++KS+ + L+
Sbjct: 168 KSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVA 227
Query: 288 DSDSEEEQKEAA----SSGDDSGRDREP--PVQRKSED---RTQLKGGKRLSGSSEDEED 338
D+ E+ +K + S ++ G+ P PV+ K + ++ ++ + E+
Sbjct: 228 DAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE 287
Query: 339 SGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRS 398
GK P +K + + +S +E S +E G G Q E + + K++ ++ +
Sbjct: 288 KGK-SPVSKS--PVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEK 344
Query: 399 SSSSSDGSPEAKGGKAGSGRRGEDHPAVMRLKRYIR 434
PE K KA S + E V+ + + ++
Sbjct: 345 KEEKPKDVPEKK--KAESPVKEEAVAEVVTITKSVK 378
Score = 61.2 bits (147), Expect = 2e-09
Identities = 80/332 (24%), Positives = 131/332 (39%), Gaps = 61/332 (18%)
Query: 54 VEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFG 113
V+EE + + +E E++ D K + S+ E + E E G + +
Sbjct: 144 VKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEE 203
Query: 114 PPAKNGVAAE------------VSPAKEENPRRASKAVEESSDEERQRD-LPAQRGEESS 160
AK E V+ AK E P +A V +S EE+ + +P EE
Sbjct: 204 AEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKG 263
Query: 161 EE-------EEKGY----------KGKT----------RKKPVVK---KQAPGKASVSRK 190
+ EEKG KGK+ K PV K ++A KA V +
Sbjct: 264 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKG 323
Query: 191 QAREESEES--EAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQK---KEQREEEVEE 245
+ +EE E+ EA ++ KK E K K++E +EE +A+ + + +E+
Sbjct: 324 EQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEK 383
Query: 246 EEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAK-------RLLGDSDSEEEQKEA 298
E KEE + K + ++ G S E K K + G + E+E KE
Sbjct: 384 ETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEK 443
Query: 299 ASSGDD------SGRDREPPVQRKSEDRTQLK 324
S ++ +G D P ++K D+++ K
Sbjct: 444 GSGREEEKGVVTNGLDLSPADEKKGGDKSEEK 475
Score = 59.3 bits (142), Expect = 9e-09
Identities = 88/393 (22%), Positives = 148/393 (37%), Gaps = 50/393 (12%)
Query: 45 EEKQALKRLVEEELLKMQVDEAASREDKLDLTKK------GKRPPTPCSDPERKRFRFNS 98
E ++AL + EE + M+ ++ + E+K + + K+ P + PE K
Sbjct: 92 EMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEK 151
Query: 99 ESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEE 158
E E G E + G AK+ A E KE S EE EE + + A+ GEE
Sbjct: 152 EEEEGQEEEEEEDEG--AKSDQAEEGGSEKE-----GSSEKEEGEQEEGETEAEAE-GEE 203
Query: 159 SSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEE-SEAEPVQRTAKKVEGNKGT 217
+ +EEK + E+SEE + E + AK + K
Sbjct: 204 AEAKEEK-------------------------KVEEKSEEVATKEELVADAKVEKPEKAK 238
Query: 218 KSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCK 277
+ +S E + + K E+ K EEKG P +S K
Sbjct: 239 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK-SPVPKSPVEEKGKSPVSKSP 297
Query: 278 QKSQAKRLLGDSDSEEEQKEA-ASSGDDSGRDREPPVQRKSEDRTQLKGGK------RLS 330
+ +AK + S EE + +A G+ + + + E++ + K K +
Sbjct: 298 VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKK 357
Query: 331 GSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAG--GGPQGERKNRSSK 388
S +E++ T S K+ T E L++E +AG GG + E ++ +K
Sbjct: 358 AESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAK 417
Query: 389 KSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGE 421
S ++ + E + + GSGR E
Sbjct: 418 GSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 450
Score = 54.7 bits (130), Expect = 2e-07
Identities = 62/328 (18%), Positives = 129/328 (39%), Gaps = 21/328 (6%)
Query: 116 AKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKP 175
A + E++ + +E + A++ EE + E + + +++ E K +G+ ++
Sbjct: 96 ALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEE 155
Query: 176 VVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQK 235
+++ QA E E E + ++ EG ++ E + EE+ + +K
Sbjct: 156 GQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEK 215
Query: 236 KEQ---REEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQA---------- 282
E+ +EE V + + E+ E+ P++ + KS + ++K ++
Sbjct: 216 SEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 275
Query: 283 -KRLLGDSDSEEEQKEAASSGDDSGRDREP-PVQRKSEDRTQLKGGKRLSGSSEDEE--D 338
K + S EE+ K S + + P P E +++ + GK E++E +
Sbjct: 276 GKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKE 335
Query: 339 SGKGEPTAKGSRKMARLGSTSGEESDLER----EVSDSEAGGGPQGERKNRSSKKSSRKG 394
+ K E K K + ES ++ EV E++ + K ++
Sbjct: 336 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 395
Query: 395 RTRSSSSSSDGSPEAKGGKAGSGRRGED 422
+ + + GS E K G R ED
Sbjct: 396 KEKEKAGGEGGSEEEGSDKGAKGSRKED 423
Score = 53.1 bits (126), Expect = 6e-07
Identities = 80/287 (27%), Positives = 125/287 (43%), Gaps = 45/287 (15%)
Query: 38 GRSHLEPEEKQALKRLVEEELLKMQVDEAASRED-----KLDLTKKGKRPPTPCSDPERK 92
G + E E ++A + EE+ ++ + +E A++E+ K++ +K K P P S E K
Sbjct: 193 GETEAEAEGEEAEAK--EEKKVEEKSEEVATKEELVADAKVEKPEKAKSP-VPKSPVEEK 249
Query: 93 RFRFNSESESGSEASSPDYFGPPAKNGVA-AEVSPAKEENPRRASKA---------VEES 142
+S + SP P + G + SP +E+ SK+ V +S
Sbjct: 250 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKS 309
Query: 143 SDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREE-SEESEA 201
EE + +GE+ EEEEK K +++ V KK+ K +K+A EE+ A
Sbjct: 310 PVEEAKSKAEVGKGEQK-EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVA 368
Query: 202 EPVQRTAK-KVEGNKGTKSL-KESEQESEEEILAQK------------KEQREEEV---- 243
E V T KV K TK K +QE E+E + K R+E++
Sbjct: 369 EVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNG 428
Query: 244 EEEEKEEDE----EKGDWKPRTR---SNGRRKSAREERSCKQKSQAK 283
E E KEE E EKG + + +NG S +E+ KS+ K
Sbjct: 429 EVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEK 475
Score = 32.0 bits (71), Expect = 1.5
Identities = 51/198 (25%), Positives = 72/198 (36%), Gaps = 38/198 (19%)
Query: 34 LAHSGRSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKR 93
+ S + HLE E K+ K L +E+ + E S E+ D KG R ++
Sbjct: 373 ITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR---------KED 423
Query: 94 FRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDL-P 152
N E E E ++E + S EE DL P
Sbjct: 424 IAVNGEVEGKEE---------------------VEQETKEKGSGREEEKGVVTNGLDLSP 462
Query: 153 AQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKA-----SVSRKQAREESEESEAEPVQRT 207
A + + EEK KT +K + + G SV+ Q EE EE+ E + T
Sbjct: 463 ADEKKGGDKSEEKVVVTKTVEK-ITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVST 521
Query: 208 AKKVEGNKGTKSLKESEQ 225
KKVE +KE Q
Sbjct: 522 -KKVEKVTSHAIVKEVTQ 538
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 75.9 bits (185), Expect = 9e-14
Identities = 96/413 (23%), Positives = 162/413 (39%), Gaps = 68/413 (16%)
Query: 64 DEAASREDKLDLTKKGKRPPTPCSD-PERKRFRFNSESESGSEASSPDYFGPPAKNGVAA 122
D+ + K +KG +P + P +K +S+S+S SE P P +
Sbjct: 134 DDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPK----ITP 189
Query: 123 EVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQ-- 180
A+ + P + ++A + ++ + + SS++ E+ T KK V KKQ
Sbjct: 190 VTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVV 249
Query: 181 --APGKASVSRKQAREESEESEAEPVQRTAKKVEGNKG-------------TKSLKESEQ 225
AP KA+ + + SE+S ++ + K ++ G KSL
Sbjct: 250 AKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPP 309
Query: 226 ESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTR---SNGRRKSAREERSCKQKSQA 282
+ E Q E E+ +E + +EEK KP T+ S K +++ + S +
Sbjct: 310 KKAVE-KQQPVESSEDSSDESDSSSEEEK---KPPTKAVVSKATTKPPPAKKAAESSSDS 365
Query: 283 KRLLGDSDSEEEQKEAASSGDDSGR----DREPPVQRKSEDRTQLKGGKRL------SGS 332
D E K A ++ + S + + P V+ + + + GG++L S S
Sbjct: 366 SDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSS 425
Query: 333 SEDEEDSGKGEPTAK------------------------GSRKMARLGSTSGEESDLERE 368
SE+E S + E T K GSR + +S E + E +
Sbjct: 426 SEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEE-EEK 484
Query: 369 VSDSEAGGGPQGERKNRSSKK--SSRKGRTRSSSSSS--DGSPEAKGGKAGSG 417
S S PQ + K S++KG+ SS+SSS D S E + G G
Sbjct: 485 TSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKG 537
Score = 71.6 bits (174), Expect = 2e-12
Identities = 85/357 (23%), Positives = 140/357 (39%), Gaps = 29/357 (8%)
Query: 79 GKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENP--RRAS 136
G +PP + ++ + +S S++SS + PP K A VS A + P ++A+
Sbjct: 305 GTQPPKKAVEKQQP-VESSEDSSDESDSSSEEEKKPPTK----AVVSKATTKPPPAKKAA 359
Query: 137 KAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASV-------SR 189
++ +SSD + D A + + T K P VK A K V +R
Sbjct: 360 ESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTR 419
Query: 190 KQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKE 249
K SEE + + KK+ K+ ++ + Q + + E
Sbjct: 420 KADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSE 479
Query: 250 EDEEKGDW-----KPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDD 304
E+EEK KP+ + G S + + K K+++ DS EE++E G
Sbjct: 480 EEEEKTSKSAVKKKPQKVAGGAAPS-KPASAKKGKAESSNSSSSDDSSEEEEEKLK-GKG 537
Query: 305 SGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAK--GSRKMARLGSTSGE- 361
S R + P S Q GK S E+EE+ K GS K + + E
Sbjct: 538 SPRPQAPKANGTSALTAQ--NGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEA 595
Query: 362 ESDLEREVSDSEAGGGPQ---GERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAG 415
E+ +++ P+ GE++ S + R+ S +D S +AK G AG
Sbjct: 596 ETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAG 652
Score = 67.0 bits (162), Expect = 4e-11
Identities = 94/378 (24%), Positives = 138/378 (36%), Gaps = 72/378 (19%)
Query: 92 KRFRFNSESESGSEASSPDYFGPPAKNGVA----AEVSPAKEENPRRASKAVEESS---D 144
K+ +S+SE SE + GPPAK + P K S + EESS D
Sbjct: 79 KKKASSSDSEDSSEEEE-EVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDD 137
Query: 145 EERQRDLPAQRG---------------------EESSEEEEKGYKGKTRKKPVVKK---Q 180
EE Q+ P Q+G +SS E+E K + PV K +
Sbjct: 138 EEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTK 197
Query: 181 APGK--------------ASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQE 226
AP K +S S + S++SE E T KK K + +
Sbjct: 198 APPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAA 257
Query: 227 SEEEILAQKKEQREEEVEEEEKEEDEEK-GDWK--------PRTRSNGRR--KSAREERS 275
+ + E + EEE+K+ + K G + P +S G + K A E++
Sbjct: 258 TTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQ 317
Query: 276 CKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSED 335
+ S+ DS SEEE+K + + PP ++ +E + S SSED
Sbjct: 318 PVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSD----SDSSED 373
Query: 336 EEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGR 395
+E K T K S + T+ + GGG K +RK
Sbjct: 374 DEAPSKPAGTTKNSSNKPAV--TTKSPAVKPAAAPKQPVGGG---------QKLLTRKAD 422
Query: 396 TRSSSSSSDGSPEAKGGK 413
+ SS S S E K K
Sbjct: 423 SSSSEEESSSSEEEKTKK 440
Score = 62.4 bits (150), Expect = 1e-09
Identities = 95/394 (24%), Positives = 148/394 (37%), Gaps = 52/394 (13%)
Query: 48 QALKRLVEEELLKMQVDEAASREDKLDLT-KKGKRPPTPC------SDPERKRFRFNSES 100
Q K+ VE++ V+ + D+ D + ++ K+PPT + P + S S
Sbjct: 307 QPPKKAVEKQ---QPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSS 363
Query: 101 ESGSEASSPDYFGPPAKNGVA-------AEVSPAKEENPRRASKAVEESSDE--ERQRDL 151
+S SS D P G A + + P A K + R+ D
Sbjct: 364 DSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADS 423
Query: 152 PAQRGEESSEEEEKGYKGKTRKKP---------VVKKQAPGKASVSRKQAREESEESEAE 202
+ E SS EEEK K KP + KQAP + S + S E E E
Sbjct: 424 SSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEE 483
Query: 203 PVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTR 262
++A K + K S+ S ++ K E ++ EE+EEK K R
Sbjct: 484 KTSKSAVKKKPQKVAGGAAPSKPASAKK---GKAESSNSSSSDDSSEEEEEKLKGKGSPR 540
Query: 263 SNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSG--RDREPPVQRKSEDR 320
+ + + + AK + EEE+K+AA SG + R+ K +
Sbjct: 541 PQAPKANGTSALTAQNGKAAK---NSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAET 597
Query: 321 TQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDS-----EAG 375
Q K K + ++ + KGE A + R EE +++ V+D+
Sbjct: 598 PQAKKIKLQTPNTFPKRK--KGEKRASSPFRRVR-----EEEIEVDSRVADNSFDAKRGA 650
Query: 376 GGPQGERKNRSSK----KSSRKGRTRSSSSSSDG 405
G GER N+ K KS R +T+ S G
Sbjct: 651 AGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRG 684
Score = 60.8 bits (146), Expect = 3e-09
Identities = 82/385 (21%), Positives = 133/385 (34%), Gaps = 56/385 (14%)
Query: 80 KRPPTPC-SDPERKRFRFNSESESGSEASSPDYFGP-----------PAKNGVAAEVSPA 127
K PP P + P+ + S S S S +SS D P K VA A
Sbjct: 197 KAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKA 256
Query: 128 KEENPRRASKAVEESSDEERQRDLPAQR--GEESS-----EEEEKGYKGKTRKKPVVKKQ 180
R++S + + SSDEE ++ P + G SS K G K V+KQ
Sbjct: 257 ATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQ 316
Query: 181 APGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQRE 240
P ++S + S E E +P + K + K +E S+
Sbjct: 317 QPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSS---------- 366
Query: 241 EEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQA----------KRLLGDSD 290
+ + ED+E T N K A +S K A K L +D
Sbjct: 367 ----DSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKAD 422
Query: 291 SEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLK-------------GGKRLSGSSEDEE 337
S ++E++SS ++ + + K+ + L S SSE+EE
Sbjct: 423 SSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEE 482
Query: 338 DSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTR 397
+ K +K+A + S S + + S + + K R +
Sbjct: 483 EKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQ 542
Query: 398 SSSSSSDGSPEAKGGKAGSGRRGED 422
+ ++ + A+ GKA E+
Sbjct: 543 APKANGTSALTAQNGKAAKNSEEEE 567
Score = 50.4 bits (119), Expect = 4e-06
Identities = 68/315 (21%), Positives = 113/315 (35%), Gaps = 54/315 (17%)
Query: 157 EESSEEEEK--GYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGN 214
E+SSEEEE+ G K P + P + ++ SEES + + KK
Sbjct: 88 EDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQ 147
Query: 215 KGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREER 274
KG K ++ + A K+ + + + + EDE + KP+ + K+ +
Sbjct: 148 KGVKPQAKAAK-------APPKKAKSSDSDSDSSSEDEPPKNQKPKI-TPVTVKAQTKAP 199
Query: 275 SCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQL----------- 323
++ K G + S ++SS DDS ++ +K+ + Q+
Sbjct: 200 PKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATT 259
Query: 324 ---KGGKRLSGSSEDEEDSGK-------------------------GEPTAKGSRKMARL 355
K SS++EE+ K +P K K +
Sbjct: 260 PTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPV 319
Query: 356 GSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDG----SPEAKG 411
S S + SD S+ E + ++K K SSS SSD EA
Sbjct: 320 ES-SEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPS 378
Query: 412 GKAGSGRRGEDHPAV 426
AG+ + + PAV
Sbjct: 379 KPAGTTKNSSNKPAV 393
Score = 47.4 bits (111), Expect = 4e-05
Identities = 50/232 (21%), Positives = 94/232 (40%), Gaps = 20/232 (8%)
Query: 170 KTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEE 229
K+ K P K QA G + K+A++++ S++E ++V+G K+ +++
Sbjct: 59 KSAKVPERKLQANGPVA---KKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLP 115
Query: 230 EILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDS 289
A K EE ++DEE D K + G + A+ ++ +K+++ DS
Sbjct: 116 PGKAAAKASESSSSEESSDDDDEE--DQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDS 173
Query: 290 DSEEE----QKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSS---------EDE 336
SE+E QK + + + PP + + ++ GK S SS + E
Sbjct: 174 SSEDEPPKNQKPKITPVTVKAQTKAPP--KPARAAPKIANGKAASSSSSSSSSSSSDDSE 231
Query: 337 EDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSK 388
E+ P +K + + R+ S SE + E + + K
Sbjct: 232 EEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMK 283
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 72.4 bits (176), Expect = 1e-12
Identities = 71/350 (20%), Positives = 151/350 (43%), Gaps = 19/350 (5%)
Query: 36 HSGRSHLEPEEK--QALKRLVEEELLKMQ-----VDEAASREDKLDLTKKGKRPPTPCSD 88
HS + ++P E QA + +EE + +++ + A E +KG R +
Sbjct: 255 HSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRS 314
Query: 89 PERKRFRFNSE---SESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDE 145
R + +S S+S + S + K+ ++ K R K+ S
Sbjct: 315 KSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSR 374
Query: 146 ERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQ 205
++++D + E+ +E+ K + R+K K++ GK + R + RE+ E + E +
Sbjct: 375 DKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGK-NKDRDKEREKDREKDKEKDR 433
Query: 206 RTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNG 265
++ E K KE EQ+ E+E +++ R +E++E+ K++ + + + S
Sbjct: 434 EREREKEHEKDRDKEKEKEQDKEKE----REKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489
Query: 266 RRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDR-TQLK 324
R S+RE R + +S ++ S+ +++++ S R+++ + K D ++ +
Sbjct: 490 SRSSSRERRRRRSRSSSR---SPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERR 546
Query: 325 GGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEA 374
+R + + D E K S + +S + +EV D +A
Sbjct: 547 ERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDA 596
Score = 66.6 bits (161), Expect = 6e-11
Identities = 72/305 (23%), Positives = 121/305 (39%), Gaps = 38/305 (12%)
Query: 129 EENPRRASKAVEESSDEERQRDL---PAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKA 185
E P+ A+K +EE R+ A E E KG + ++ + + + +
Sbjct: 265 EMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHS 324
Query: 186 SVSRKQAREESEE---SEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEE 242
R Q++ S S + R K K +KS + + S ++K+ RE+
Sbjct: 325 RRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKI 384
Query: 243 VEEEE-KEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASS 301
E+E KE+D EK + RE+ K+K + K D D E E+
Sbjct: 385 KEKERVKEKDREK-------------EREREKEREKEKERGKNK--DRDKEREKDREKDK 429
Query: 302 GDDSGRDREPPVQR---KSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGST 358
D R+RE ++ K +++ Q K +R S++ ++ K + K SR R +
Sbjct: 430 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD---KKSRTPPRSYNA 486
Query: 359 SGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGR 418
S RE + R++RSS +S R +T SS SP ++ K
Sbjct: 487 SRRSRSSSRE----------RRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 536
Query: 419 RGEDH 423
+ DH
Sbjct: 537 KERDH 541
Score = 62.0 bits (149), Expect = 1e-09
Identities = 71/339 (20%), Positives = 134/339 (39%), Gaps = 28/339 (8%)
Query: 100 SESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEES 159
+ S + P P A EV E S A+E S + +R R
Sbjct: 254 NHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTR 313
Query: 160 SEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKG-TK 218
S+ RK+ K ++ S +R ++R++ P ++ +K E K ++
Sbjct: 314 SKSRSSSKSHSRRKRSQSKHRS---RSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSR 370
Query: 219 SLKESEQESEEEILAQKK--EQREEEVEEEE-KEEDEEKGDWKPRTRSNGRRKSAREERS 275
S +++ E + +K+ ++++ E E E KE ++EK K + R R K RE+
Sbjct: 371 SHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD-REKDK 429
Query: 276 CKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSED 335
K + + + + D ++E+++ + +DR + K + + + R +S
Sbjct: 430 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489
Query: 336 EEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKK------ 389
S SR+ R S S S + ++ P +N+ KK
Sbjct: 490 SRSS---------SRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD 540
Query: 390 --SSRKGRTRSSS---SSSDGSPEAKGGKAGSGRRGEDH 423
S R+ R RS+S SS+D + K K + + ++H
Sbjct: 541 HISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 579
Score = 37.4 bits (85), Expect = 0.036
Identities = 45/210 (21%), Positives = 87/210 (41%), Gaps = 21/210 (10%)
Query: 229 EEILAQKKEQRE---EEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAK-R 284
EE++ + +E + +E E + +E KG + R+ + + +S+ + S +++SQ+K R
Sbjct: 276 EEVMKRVREAQSFISAAIEPESGKSNERKGG-RSRSHTRSKSRSSSKSHSRRKRSQSKHR 334
Query: 285 LLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEP 344
+ S QK+ S + P +++S+ R + K R S S + +D+
Sbjct: 335 SRSHNRSRSRQKDRRRS--------KSPHKKRSKSRERRKSRSR-SHSRDKRKDT---RE 382
Query: 345 TAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGER---KNRSSKKSSRKGRTRSSSS 401
K ++ E + ERE + E G ++ K+R K + R R
Sbjct: 383 KIKEKERVKEKDREKEREREKERE-KEKERGKNKDRDKEREKDREKDKEKDREREREKEH 441
Query: 402 SSDGSPEAKGGKAGSGRRGEDHPAVMRLKR 431
D E + + R +D + KR
Sbjct: 442 EKDRDKEKEKEQDKEKEREKDRSKEIDEKR 471
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 72.4 bits (176), Expect = 1e-12
Identities = 71/350 (20%), Positives = 151/350 (43%), Gaps = 19/350 (5%)
Query: 36 HSGRSHLEPEEK--QALKRLVEEELLKMQ-----VDEAASREDKLDLTKKGKRPPTPCSD 88
HS + ++P E QA + +EE + +++ + A E +KG R +
Sbjct: 139 HSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRS 198
Query: 89 PERKRFRFNSE---SESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDE 145
R + +S S+S + S + K+ ++ K R K+ S
Sbjct: 199 KSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSR 258
Query: 146 ERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQ 205
++++D + E+ +E+ K + R+K K++ GK + R + RE+ E + E +
Sbjct: 259 DKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGK-NKDRDKEREKDREKDKEKDR 317
Query: 206 RTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNG 265
++ E K KE EQ+ E+E +++ R +E++E+ K++ + + + S
Sbjct: 318 EREREKEHEKDRDKEKEKEQDKEKE----REKDRSKEIDEKRKKDKKSRTPPRSYNASRR 373
Query: 266 RRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDR-TQLK 324
R S+RE R + +S ++ S+ +++++ S R+++ + K D ++ +
Sbjct: 374 SRSSSRERRRRRSRSSSR---SPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERR 430
Query: 325 GGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEA 374
+R + + D E K S + +S + +EV D +A
Sbjct: 431 ERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDA 480
Score = 66.6 bits (161), Expect = 6e-11
Identities = 72/305 (23%), Positives = 121/305 (39%), Gaps = 38/305 (12%)
Query: 129 EENPRRASKAVEESSDEERQRDL---PAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKA 185
E P+ A+K +EE R+ A E E KG + ++ + + + +
Sbjct: 149 EMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHS 208
Query: 186 SVSRKQAREESEE---SEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEE 242
R Q++ S S + R K K +KS + + S ++K+ RE+
Sbjct: 209 RRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKI 268
Query: 243 VEEEE-KEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASS 301
E+E KE+D EK + RE+ K+K + K D D E E+
Sbjct: 269 KEKERVKEKDREK-------------EREREKEREKEKERGKNK--DRDKEREKDREKDK 313
Query: 302 GDDSGRDREPPVQR---KSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGST 358
D R+RE ++ K +++ Q K +R S++ ++ K + K SR R +
Sbjct: 314 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD---KKSRTPPRSYNA 370
Query: 359 SGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGR 418
S RE + R++RSS +S R +T SS SP ++ K
Sbjct: 371 SRRSRSSSRE----------RRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 420
Query: 419 RGEDH 423
+ DH
Sbjct: 421 KERDH 425
Score = 62.0 bits (149), Expect = 1e-09
Identities = 71/339 (20%), Positives = 134/339 (39%), Gaps = 28/339 (8%)
Query: 100 SESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEES 159
+ S + P P A EV E S A+E S + +R R
Sbjct: 138 NHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTR 197
Query: 160 SEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKG-TK 218
S+ RK+ K ++ S +R ++R++ P ++ +K E K ++
Sbjct: 198 SKSRSSSKSHSRRKRSQSKHRS---RSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSR 254
Query: 219 SLKESEQESEEEILAQKK--EQREEEVEEEE-KEEDEEKGDWKPRTRSNGRRKSAREERS 275
S +++ E + +K+ ++++ E E E KE ++EK K + R R K RE+
Sbjct: 255 SHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD-REKDK 313
Query: 276 CKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSED 335
K + + + + D ++E+++ + +DR + K + + + R +S
Sbjct: 314 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 373
Query: 336 EEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKK------ 389
S SR+ R S S S + ++ P +N+ KK
Sbjct: 374 SRSS---------SRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD 424
Query: 390 --SSRKGRTRSSS---SSSDGSPEAKGGKAGSGRRGEDH 423
S R+ R RS+S SS+D + K K + + ++H
Sbjct: 425 HISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 463
Score = 37.4 bits (85), Expect = 0.036
Identities = 45/210 (21%), Positives = 87/210 (41%), Gaps = 21/210 (10%)
Query: 229 EEILAQKKEQRE---EEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAK-R 284
EE++ + +E + +E E + +E KG + R+ + + +S+ + S +++SQ+K R
Sbjct: 160 EEVMKRVREAQSFISAAIEPESGKSNERKGG-RSRSHTRSKSRSSSKSHSRRKRSQSKHR 218
Query: 285 LLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEP 344
+ S QK+ S + P +++S+ R + K R S S + +D+
Sbjct: 219 SRSHNRSRSRQKDRRRS--------KSPHKKRSKSRERRKSRSR-SHSRDKRKDT---RE 266
Query: 345 TAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGER---KNRSSKKSSRKGRTRSSSS 401
K ++ E + ERE + E G ++ K+R K + R R
Sbjct: 267 KIKEKERVKEKDREKEREREKERE-KEKERGKNKDRDKEREKDREKDKEKDREREREKEH 325
Query: 402 SSDGSPEAKGGKAGSGRRGEDHPAVMRLKR 431
D E + + R +D + KR
Sbjct: 326 EKDRDKEKEKEQDKEKEREKDRSKEIDEKR 355
>gi|50962882 G patch domain containing 8 [Homo sapiens]
Length = 1502
Score = 71.2 bits (173), Expect = 2e-12
Identities = 85/388 (21%), Positives = 147/388 (37%), Gaps = 45/388 (11%)
Query: 37 SGRSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRF 96
SG+SH ++K+ K + K +E +S+ + + +KK K+ RKR +
Sbjct: 669 SGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKK---------RKRKKN 719
Query: 97 NSESESGSEAS-SPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQR 155
S + + SE P+ PP SPA RRA D+ ++R LPA+
Sbjct: 720 KSSAPADSERGPKPE---PPGSG------SPAPPRRRRRAQ-------DDSQRRSLPAEE 763
Query: 156 GEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNK 215
G ++E G G +S + + E + +R K
Sbjct: 764 GSSGKKDEGGG----------------GSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRS 807
Query: 216 GTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERS 275
+S S E ++ + + Q+ EE EE+E+ G R+RS R+ + S
Sbjct: 808 SHRSQPSSGDEDSDDASSHRLHQKSPSQYSEE-EEEEDSGSEHSRSRSRSGRRHSSHRSS 866
Query: 276 CKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSED 335
+ S + D Q+ + DR ++S D S
Sbjct: 867 RRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRH 926
Query: 336 EEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGR 395
+ S + + S+ +R S + E S R S S + + +R++RS+ S + R
Sbjct: 927 KYSSSDDDYSLSCSQSRSRSRSHTRERS-RSRGRSRSSSCSRSRSKRRSRSTTAHSWQ-R 984
Query: 396 TRSSSSSSDGSPEAKGGKAGSGRRGEDH 423
+RS S S + ++GS +R H
Sbjct: 985 SRSYSRDRSRSTRSPSQRSGSRKRSWGH 1012
Score = 50.8 bits (120), Expect = 3e-06
Identities = 76/364 (20%), Positives = 134/364 (36%), Gaps = 39/364 (10%)
Query: 92 KRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAK-EENPRRASKAVEESSDEERQRD 150
K SE GS+A AK + +VS E + ++ S+ S+ ++
Sbjct: 466 KETSMTEPSEPGSKAE--------AKKALGGDVSDQSLESHSQKVSETQMCESNSSKETS 517
Query: 151 LPAQRGEESSEEEEKGYKGKTRKK-PVVKK------QAPGKASVSRKQAREESEESEAEP 203
L G+ES E G K T PV+ K Q P + + K E S P
Sbjct: 518 LATPAGKESQE----GPKHPTGPFFPVLSKDESTALQWPSELLIFTKA--EPSISYSCNP 571
Query: 204 V----QRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKP 259
+ + + K KGT+ K+ S++ + + ++ E + +E G K
Sbjct: 572 LYFDFKLSRNKDARTKGTEKPKDIGSSSKDHL---------QGLDPGEPNKSKEVGGEKI 622
Query: 260 RTRSNGRRKSAREERSCKQ-KSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSE 318
S GR + +C Q S++E+ + S + SG+ ++K +
Sbjct: 623 VRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRH--KKKKK 680
Query: 319 DRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGG- 377
+ K ++ +E++ + +K +K R + S +D ER G G
Sbjct: 681 HKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGS 740
Query: 378 PQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGEDHPAVMRLKRYIRACG 437
P R+ R ++ S++ + SS E GG + G H + R G
Sbjct: 741 PAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAG 800
Query: 438 AHRN 441
R+
Sbjct: 801 TKRS 804
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 70.5 bits (171), Expect = 4e-12
Identities = 90/396 (22%), Positives = 156/396 (39%), Gaps = 75/396 (18%)
Query: 36 HSGRSHLEPEEKQAL-------KRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSD 88
H R+ + EE++ L K L+ ++LLK Q ++ +++ KK +
Sbjct: 827 HVARARKQDEEERELRAKQEQEKELLRQKLLKEQEEKRLREKEE---QKKLLEQRAQYVE 883
Query: 89 PERKRFRFNSESESGSEASSPDYFGPPAKNG----------VAAEVSPAKEENPRRASKA 138
+ F E+E+ E G +K G ++ +K++ R+ S +
Sbjct: 884 KTKNILMFTGETEATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGS 943
Query: 139 VEESSDEE-----RQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAR 193
+E DEE +++ +GEE S+++E T P KK+ P KA
Sbjct: 944 EQEGEDEEGGERKKKKRRRHPKGEEGSDDDE------TENGPKPKKRRPPKA-------- 989
Query: 194 EESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEE 253
E+ +A +R ++G +K++ S +S +E + ++ + DE+
Sbjct: 990 ---EKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRNSNSNSDSDED 1046
Query: 254 KGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPV 313
+ R+K A E SDS+E Q + SG ++G R P
Sbjct: 1047 EQ----------RKKCASSE---------------SDSDENQNK---SGSEAGSPRRPRR 1078
Query: 314 QRKSE--DRTQLKGGKRLSGSSEDEEDSGKGEPTAKG-SRKMARLGSTSGEESDLEREVS 370
QR + D Q +R SGS + + +S + + G S +R S S E S
Sbjct: 1079 QRSDQDSDSDQPSRKRRPSGSEQSDNESVQSGRSHSGVSENDSRPASPSAESDHESERGS 1138
Query: 371 DSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGS 406
D+E G QG + S+ + R S SD S
Sbjct: 1139 DNEGSG--QGSGNESEPEGSNNEASDRGSEHGSDDS 1172
Score = 67.4 bits (163), Expect = 3e-11
Identities = 60/239 (25%), Positives = 112/239 (46%), Gaps = 48/239 (20%)
Query: 223 SEQESEEEILAQK--KEQREEEVEEEEKEED--EEKGDWKPRTRS----NGRRKSAREE- 273
++QE E+E+L QK KEQ E+ + E+E+++ E++ + +T++ G ++ +E+
Sbjct: 843 AKQEQEKELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKK 902
Query: 274 ------RSCKQKSQAKRLLGDSD------SEEEQKEAASSGDDSGRDREPPVQRKSEDRT 321
R K+ + + D S+++++ S + G D E ++K + R
Sbjct: 903 RGGGGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEGGERKKKKRRR 962
Query: 322 QLKGGKRLSGSSEDEEDSG---------KGE-----------PTAKGSRKMARLGSTSGE 361
KG + GS +DE ++G K E P+ KG K + S+S +
Sbjct: 963 HPKGEE---GSDDDETENGPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAIISSSDD 1019
Query: 362 ESDLER-EVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRR 419
SD ++ +++D G P+ N S + ++ + SS S SD + G +AGS RR
Sbjct: 1020 SSDEDKLKIADE---GHPRNSNSNSDSDEDEQRKKCASSESDSDENQNKSGSEAGSPRR 1075
Score = 63.5 bits (153), Expect = 5e-10
Identities = 68/320 (21%), Positives = 134/320 (41%), Gaps = 55/320 (17%)
Query: 145 EERQRDLPAQRGEESS--------EEEEKGYKGKTRKKPVVKKQAP------------GK 184
+E +R+L A++ +E E+EEK + K +K +++++A G+
Sbjct: 835 DEEERELRAKQEQEKELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGE 894
Query: 185 ASVSRKQAR--------------EESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEE 230
++++ R +E + + +KK + KG+ S +E E E E
Sbjct: 895 TEATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEGGE 954
Query: 231 ILAQKKEQREEEVEEEEKEEDEEKGDWKPRTR---SNGRRKSAREER---SCKQKSQAKR 284
+KK++R EE ++DE + KP+ R ++K+ + ER S K K ++K
Sbjct: 955 --RKKKKRRRHPKGEEGSDDDETENGPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKA 1012
Query: 285 LLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEP 344
++ SD ++ + + D G R S++ Q ++ SSE + D + +
Sbjct: 1013 IISSSDDSSDEDKLKIA--DEGHPRNSNSNSDSDEDEQ----RKKCASSESDSDENQNKS 1066
Query: 345 TAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSD 404
++ S ++SD ++ G Q S +S + GR+ S S +D
Sbjct: 1067 GSEAGSPRRPRRQRSDQDSDSDQPSRKRRPSGSEQ------SDNESVQSGRSHSGVSEND 1120
Query: 405 GSPEAKGGKAG-SGRRGEDH 423
P + ++ RG D+
Sbjct: 1121 SRPASPSAESDHESERGSDN 1140
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 70.1 bits (170), Expect = 5e-12
Identities = 93/375 (24%), Positives = 158/375 (42%), Gaps = 48/375 (12%)
Query: 121 AAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQ 180
A E E N R+ + VE+ R+R R S + + K+R + K
Sbjct: 156 ALEKLDGTEVNGRKI-RLVEDKPGSRRRRSYSRSRSHSRSRSRSR-HSRKSRSRSGSSKS 213
Query: 181 APGKA-SVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQR 239
+ K+ S SR +R S+ + +KK + +K S S + ++ K+Q
Sbjct: 214 SHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQA 273
Query: 240 EEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAA 299
EE+++ + KP++RS R KS + RS +SQ +R+ EEE++ +
Sbjct: 274 EEKIQNNDNVG-------KPKSRSPSRHKSKSKSRS---RSQERRV------EEEKRGSV 317
Query: 300 SSGDDSGRDREPPVQRKSEDRTQLKGGKRL-SGSSEDEEDSGKGEPTAKGSRKMARLGST 358
S G R +E + R+S R++ KGG R S S +D KG K SR+ +R S
Sbjct: 318 SRG----RSQEKSL-RQSRSRSRSKGGSRSRSRSRSKSKDKRKGR---KRSREESRSRSR 369
Query: 359 SGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRK------GRTRSSSSSSDGSPEAKGG 412
S +S+ R+ +G +++ S SS+K R++S S S S E +
Sbjct: 370 SRSKSERSRK----------RGSKRD-SKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHA 418
Query: 413 KAGSGR---RGEDHPAVMRLKRYIRACGAHRNYKKLLGSCCSHKERLSILRAELEALGMK 469
K+ S + RGE A + R+ ++ L S + S R+ ++
Sbjct: 419 KSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRS 478
Query: 470 GTPSLGKCRALKEQR 484
+ S + R+ R
Sbjct: 479 ASRSPSRSRSRSHSR 493
Score = 68.6 bits (166), Expect = 1e-11
Identities = 92/399 (23%), Positives = 162/399 (40%), Gaps = 58/399 (14%)
Query: 35 AHSGRSH---LEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPER 91
AH GR + +E +KR +E K+ E R+ +L K G R R
Sbjct: 135 AHKGRKNEGVIEFVSYSDMKRALE----KLDGTEVNGRKIRLVEDKPGSR---------R 181
Query: 92 KRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDL 151
+R S S S S + S +++G + SK+ S R R
Sbjct: 182 RRSYSRSRSHSRSRSRSRHSRKSRSRSG----------SSKSSHSKSRSRSRSGSRSRSK 231
Query: 152 PAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKV 211
R + S +++ + +++K + + GK SR ++++++EE K+
Sbjct: 232 SRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGK---SRSKSKDQAEE-----------KI 277
Query: 212 EGNKGT---KSLKESEQESEEEILAQKKEQREEEVEEEE--KEEDEEKGDWKPRTRSNGR 266
+ N KS S +S+ + ++ +E+R EE + + +EK + R+RS +
Sbjct: 278 QNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSK 337
Query: 267 RKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQR---------KS 317
S RS + KS+ KR G S EE + + S S R R+ +R K
Sbjct: 338 GGSRSRSRS-RSKSKDKR-KGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKK 395
Query: 318 EDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGG 377
++ T + S S E + K E + + R + T+ E R S+S++
Sbjct: 396 KEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSR--SNSKSKPN 453
Query: 378 PQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGS 416
E ++RS S + R++S S S+ SP ++ S
Sbjct: 454 LPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHS 492
Score = 58.2 bits (139), Expect = 2e-08
Identities = 78/339 (23%), Positives = 131/339 (38%), Gaps = 36/339 (10%)
Query: 89 PERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQ 148
P R + S G S D +GPP + V EN + +
Sbjct: 73 PRRDGSYGSGRSGYGYRRSGRDKYGPPTRTEYRLIV-----EN-------LSSRCSWQDL 120
Query: 149 RDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTA 208
+D Q GE + + KG K + + V + K+A E+ + +E R
Sbjct: 121 KDYMRQAGEVTYADAHKGRKNEGVIEFV--------SYSDMKRALEKLDGTEVNG--RKI 170
Query: 209 KKVEGNKGTKSLKE-SEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRR 267
+ VE G++ + S S ++ + R+ + K + R+RS R
Sbjct: 171 RLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKS--RSRSRSGSRS 228
Query: 268 KSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGK 327
+S RS + +S++K+ S S+E+ + + S S + + K ++ + GK
Sbjct: 229 RSKSRSRS-QSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNV--GK 285
Query: 328 RLSGSSEDEEDSGKGEPTAKGSR-KMARLGSTS---GEESDLEREVSDSEAGGGPQGERK 383
S S + K ++ R + + GS S +E L + S S + GG + +
Sbjct: 286 PKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSR 345
Query: 384 NRSSKKSSRKGRTR----SSSSSSDGSPEAKGGKAGSGR 418
+RS K RKGR R S S S S + K GS R
Sbjct: 346 SRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKR 384
Score = 53.9 bits (128), Expect = 4e-07
Identities = 69/359 (19%), Positives = 142/359 (39%), Gaps = 42/359 (11%)
Query: 1 MAREKEMQEFTRSFFRGRPDLSTLTHSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLK 60
+ +K RS+ R R + + S R+ + SG S + ++ R K
Sbjct: 172 LVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSK 231
Query: 61 MQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKN-- 118
+ SR +KK K P +++ R S S S + S D +N
Sbjct: 232 SR-----SRSQSRSRSKKEKS-----RSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNND 281
Query: 119 --GVAAEVSPAKEENPRRA-SKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKP 175
G SP++ ++ ++ S++ E +EE++ + R +E S + + + +++
Sbjct: 282 NVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRS-RSRSKGGS 340
Query: 176 VVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQK 235
+ ++ K+ RK + EES + R+ K E ++ S ++S+ S
Sbjct: 341 RSRSRSRSKSKDKRKGRKRSREESRSR--SRSRSKSERSRKRGSKRDSKAGS-------- 390
Query: 236 KEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQ 295
+++K+ED ++ + +RS ++E K +S + G+S++
Sbjct: 391 --------SKKKKKEDTDRSQSRSPSRS-----VSKEREHAKSESSQREGRGESENAGTN 437
Query: 296 KEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMAR 354
+E S + + + SE R++ K + S+ S P+ SR +R
Sbjct: 438 QETRSRSRSNSKSKP---NLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSR 493
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 69.7 bits (169), Expect = 7e-12
Identities = 90/367 (24%), Positives = 164/367 (44%), Gaps = 38/367 (10%)
Query: 9 EFTRS---FFRGRPDLSTLTHSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLKMQVDE 65
EFTR F +G+ L+ + ++++R + L K AL++L +E K+ +E
Sbjct: 2037 EFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILK-ALQKLTRDER-KLTQEE 2094
Query: 66 AASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVS 125
+ K L K +R S + K + F SE SE + K+
Sbjct: 2095 IKMTKMKRALFVKERRLSIEQSKLDIKEWDF---SEKRSELT---------KDEKKLARK 2142
Query: 126 PAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKG----------YKGKTRKKP 175
K N R EE EE + L + E ++EE+G K + RK+
Sbjct: 2143 QRKLANKMRRMINKEEKMTEEESK-LARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRK 2201
Query: 176 VVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSL----KESEQESEEEI 231
K+ K S + ESEE +E ++ ++E + S +E E+E EEE
Sbjct: 2202 EAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEE 2261
Query: 232 LAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQ--AKRLLGDS 289
+ +++E+R+EE E EEK+ ++E+ + K + + + + +E ++K + ++
Sbjct: 2262 VREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESL 2321
Query: 290 DSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGS 349
EEE++E+ S ++ R++E ++++ + + Q + K L G E +G P KG
Sbjct: 2322 SDEEEEEESCSLEEEVDREKE-ILKKEKQFKLQEQRRKSLRG-RERVLSILRGVPHGKG- 2378
Query: 350 RKMARLG 356
+ RLG
Sbjct: 2379 -RAIRLG 2384
Score = 53.5 bits (127), Expect = 5e-07
Identities = 85/367 (23%), Positives = 151/367 (41%), Gaps = 48/367 (13%)
Query: 55 EEELLKMQVDEAASREDKLDLTKKGKRP----------PTPCSDPERKRFRFNSESESGS 104
EEE + + + E+ + KKGK+ S E K+ F + G
Sbjct: 1346 EEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKK-TFQKSPKQGR 1404
Query: 105 EASSPDYFGPPAKNGVAAEVSPAKEENPRRAS---KAVEESSDEERQRDLPAQRGEESSE 161
+A + K + E EE A+ K V++ P+ + + +
Sbjct: 1405 KAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAW 1464
Query: 162 EEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEES---EAEPVQRTAK-------KV 211
+E K G+TRK K+ K + ++ ++ E E E +Q K +V
Sbjct: 1465 DEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQV 1524
Query: 212 EGNKGTKSLKESEQESEEEILAQKK-----EQREEEVEEEEKE-EDEEKGDWKPRTRSNG 265
N + KE + + EEE+ +++ E++E++V EE++ ++E K R R+
Sbjct: 1525 WENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARA 1584
Query: 266 RRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQR---KSEDRTQ 322
+K A+EER Q+ + ++EE+K A + + DRE ++ T
Sbjct: 1585 EKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETL 1644
Query: 323 LKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGER 382
+ G++L S E E+ + K + AK K+AR EE L ++ GG E
Sbjct: 1645 AQRGEKL--SQEAEKLAQKRKKLAKKWEKVAR------EEEKLAKK-------GGKLAEV 1689
Query: 383 KNRSSKK 389
KN ++K
Sbjct: 1690 KNILAQK 1696
Score = 47.0 bits (110), Expect = 5e-05
Identities = 68/287 (23%), Positives = 121/287 (42%), Gaps = 41/287 (14%)
Query: 51 KRLVEEELL------KMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGS 104
KRL++EE K+ +E +EDK ++ K+ + K ++ E E
Sbjct: 1487 KRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTL 1546
Query: 105 EASSPDYFGPPAKNGVAAEVSPAKEENP-----RRASKAVEESSDEER----QRDLPAQR 155
E G + V E +EE+ R+ ++A ++ + EER + + AQ
Sbjct: 1547 E-EEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQE 1605
Query: 156 GEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQA----REESEESEAEPVQRTAKKV 211
+ ++EE K + + ++ A + ++K+ R E EAE + + KK+
Sbjct: 1606 ERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKL 1665
Query: 212 EGNKGTKSLKESEQESEE--------EILAQKKE---QREEEVEEEEKEE---------D 251
K K +E E+ +++ ILAQK E QRE+ ++ +EKE D
Sbjct: 1666 -AKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWD 1724
Query: 252 EEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEA 298
E+ WK + K E++ ++ +A + SEEE K A
Sbjct: 1725 MEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLA 1771
Score = 41.2 bits (95), Expect = 0.003
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 17/177 (9%)
Query: 153 AQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVE 212
AQRGE+ S+E EK + ++K + KK K AREE + ++ K +
Sbjct: 1645 AQRGEKLSQEAEKLAQ---KRKKLAKKW--------EKVAREEEKLAKKGGKLAEVKNIL 1693
Query: 213 GNKGTKSLKESEQ--ESEEEILAQKKEQREEEVEE---EEKEEDEEKGDWKPRTRSNGRR 267
K + L + EQ + +E+ LAQ+ E+ E ++EE +E+E ++E+G +
Sbjct: 1694 AQK-VEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEE 1752
Query: 268 KSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLK 324
+ A + K + +L + + ++KE + + + E + RK E + K
Sbjct: 1753 EEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKK 1809
Score = 35.4 bits (80), Expect = 0.14
Identities = 54/225 (24%), Positives = 97/225 (43%), Gaps = 43/225 (19%)
Query: 128 KEEN-PRRASKAVEESSDEERQRDLPAQRGEESSEEEEK----GYKGKTRKKPVVKK--- 179
KEE +R K +E+ ++R A++ E+ + EEEK G K K + +K
Sbjct: 1640 KEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEE 1699
Query: 180 --QAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKE--------------- 222
Q K+ +E EE E + + + K+ E N+ L E
Sbjct: 1700 LPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQ 1759
Query: 223 ----SEQES----EEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREER 274
SE+E+ EEE+L Q+KE+ + +E+ EE+E G + + + + + ER
Sbjct: 1760 REKLSEEETKLAQEEELLIQEKEKLAQH-KEKMPEEEERLGRKREQLIEKKMKLAQKRER 1818
Query: 275 ---SCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRK 316
S ++ ++ K +L ++K A + +++E QRK
Sbjct: 1819 WINSMEELTKNKMIL------YQKKNLAQEKKNLAQEKEKLAQRK 1857
Score = 34.7 bits (78), Expect = 0.24
Identities = 60/262 (22%), Positives = 103/262 (39%), Gaps = 44/262 (16%)
Query: 30 RRRYLAHSGRSHLEPEEKQALK--RLVE-EELLKMQVDEAASREDKLDLTKKGKRPPTPC 86
+R+ LA EEK A K +L E + +L +V+E RE LD +K
Sbjct: 1661 KRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQ---- 1716
Query: 87 SDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEE 146
E + ++ E E+S +EE + K VEE
Sbjct: 1717 ---ELEELEWDME-----------------------ELSWKEEELNQEEGKLVEEKKKLA 1750
Query: 147 RQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQR 206
+ + A + E+ SEEE K ++ + Q K + +++ EE E + Q
Sbjct: 1751 EEEEALAWQREKLSEEETK-----LAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQL 1805
Query: 207 TAKKVE-GNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNG 265
KK++ K + + E+ ++ +++ +K+ + +E+K +EK R + N
Sbjct: 1806 IEKKMKLAQKRERWINSMEELTKNKMILYQKKN----LAQEKKNLAQEKEKLAQR-KENL 1860
Query: 266 RRKSAREERSCKQKSQAKRLLG 287
R S KQ Q K LG
Sbjct: 1861 LYNKERLTHSKKQLVQVKNKLG 1882
Score = 30.4 bits (67), Expect = 4.4
Identities = 42/206 (20%), Positives = 81/206 (39%), Gaps = 17/206 (8%)
Query: 138 AVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESE 197
+++ S E + L E SE K KG+ R + VKK + +K +S+
Sbjct: 1050 SLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLRGLKKTKERDSK 1109
Query: 198 ESEAEPVQRTAKKVEGNKGTKSLK-ESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGD 256
+ EP +E GT++ E E+ S + + + + +E+D K
Sbjct: 1110 QMSTEP-----GLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISKDH 1164
Query: 257 WKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRK 316
+ + + R++++ QK + K +++ KEA +++ PPV +
Sbjct: 1165 IALTLKRLQKIRDKRDKKATAQKLKKKH-------KKKGKEAKVINEET----TPPVMEQ 1213
Query: 317 SEDRTQLKGGKRLSGSSEDEEDSGKG 342
+ G+ SG S +G G
Sbjct: 1214 PVTKKVKIQGRGASGISGRRSTAGDG 1239
Score = 29.6 bits (65), Expect = 7.6
Identities = 31/138 (22%), Positives = 62/138 (44%), Gaps = 5/138 (3%)
Query: 153 AQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVE 212
AQ E+ ++E+E K K + KK + S+++KQ + E+ + + V+
Sbjct: 1889 AQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMK---LALEKAMVQ 1945
Query: 213 GNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSARE 272
G K + + +E E+ + + K EE++ E +E KG+ P T + +
Sbjct: 1946 GKKRLRGELDIAKE-EKALNLEMKRLAEEKMRLVEGKETLSKGE-TPETSRQRKMTQVEQ 2003
Query: 273 ERSCKQKSQAKRLLGDSD 290
E ++ S +++L D
Sbjct: 2004 ELFERKLSLEEKILLHED 2021
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 69.3 bits (168), Expect = 9e-12
Identities = 107/502 (21%), Positives = 189/502 (37%), Gaps = 82/502 (16%)
Query: 18 RPDLSTLTHSIVR---RRYLAHSGRSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLD 74
+PD S +T + +A+ S LE + L +E E ++ +
Sbjct: 178 KPDTSLITQGVPTPGPSANVANDAMSILE-----TITSLNQEASAARASTETSNAKTSER 232
Query: 75 LTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEE---- 130
+KK PT + +++R SE + E S+ D G E +P EE
Sbjct: 233 ASKKLPSQPTTDTSTDKER---TSEDMADKEKSTAD------SGGEGLETAPKSEEFSDL 283
Query: 131 ---------------NPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKP 175
N +K V++ S E++ + +GE+ + EKG + K +K+
Sbjct: 284 PCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKS--TDKGEKKPDSNEKGERKKEKKEK 341
Query: 176 VVKKQAPGKAS------VSRKQAREESEESEAEPVQRT---AKKVEGNK----------- 215
KK K S KQA+E+ ES P ++ AK VEG K
Sbjct: 342 TEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVD 401
Query: 216 ----------GTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNG 265
T L E+++EEE++ + E ++E++ + K + S G
Sbjct: 402 GLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEG 461
Query: 266 RRKSAREERSCKQKSQAKRLLGDSDSE---EEQKEAASSGDDSGRDREPPVQRKSEDRTQ 322
+ KS R K +K DSD E E+++++ + + R + K E++ +
Sbjct: 462 KTKSVRHAYVHKPYLYSK-YYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRK 520
Query: 323 LKGGKRLSGSSEDEEDSG---KGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQ 379
K K S ++ + S + T K AR+ E LE++V+ S+
Sbjct: 521 QKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDS 580
Query: 380 GERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGR----RGEDHPAVMRLKRYIRA 435
+ S KK + ++ + +S+ + K + + + E RL +
Sbjct: 581 RNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHV 640
Query: 436 CGAHRNYKKLLGSCCSHKERLS 457
++N KL HK R S
Sbjct: 641 VDENKNESKLER---EHKRRTS 659
Score = 51.6 bits (122), Expect = 2e-06
Identities = 64/270 (23%), Positives = 110/270 (40%), Gaps = 33/270 (12%)
Query: 42 LEPEEKQALKRLVEEELLKMQVDEAASREDKLDL---TKKGKRPPTPCSDPERKRFRFNS 98
+E EE+ KR ++ L + DE D LD T + + P T D + + R
Sbjct: 2761 VEEEERHMPKRKRKQHYLSSE-DEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLE 2819
Query: 99 E-SESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGE 157
E ++ SE +S K+ ++ S E P + +S +E++ + +RG
Sbjct: 2820 ELPKTSSETNSTTSRVMEEKDEYSS--SETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGR 2877
Query: 158 ESSEEEEKGYKGKTRKKP----VVKKQAPGKASVSRKQAREESEES-----------EAE 202
E K K K V +Q+P + + Q E ++E+ + E
Sbjct: 2878 PRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGE 2937
Query: 203 PVQRTAKKVEGNKGTKSLKESE-----------QESEEEILAQKKEQREEEVEEEEKEED 251
T+ + G K +SL S+ Q+S + + KKEQ +E EEEE+E++
Sbjct: 2938 EKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDE 2997
Query: 252 EEKGDWKPRTRSNGRRKSAREERSCKQKSQ 281
+ TRS +R + S K+K +
Sbjct: 2998 PSGATTRSTTRSEAQRSKTQLSPSIKRKRE 3027
Score = 50.8 bits (120), Expect = 3e-06
Identities = 71/317 (22%), Positives = 125/317 (39%), Gaps = 47/317 (14%)
Query: 89 PERKRFRFNSESESGSEASSPDYFGPPAKNGVA----AEVSPAKEENPRRASKAVEESSD 144
P+RKR + SE + +PD + E KEEN R + + SS+
Sbjct: 2769 PKRKRKQHYLSSEDEPD-DNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSE 2827
Query: 145 EERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASV-SRKQAREESEESEAEP 203
+ +E S E G K + +K Q + + RK+ R P
Sbjct: 2828 TNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKY-----P 2882
Query: 204 VQRTAKKVEGNK---GTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPR 260
V+ T K + +K G ++++S S+ +++ Q E +E +E+ + G+ K
Sbjct: 2883 VETTLKMKDDSKTDTGIVTVEQSPSSSKLKVM-QTDESNKETANLQERSISNDDGEEKIV 2941
Query: 261 TRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDR 320
T + RR+ + +RS A+ SE E+K S D PV+ K E
Sbjct: 2942 T--SVRRRGRKPKRSLTVSDDAE------SSEPERKRQKSVSD--------PVEDKKEQE 2985
Query: 321 TQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGE---ESDLEREVSDSEAGGG 377
S E+EE+ + EP+ +R R + + ++R+ S G
Sbjct: 2986 -----------SDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGAR 3034
Query: 378 PQGERKNRSS--KKSSR 392
+G+++ + KK+ R
Sbjct: 3035 TRGQQRVEEAPVKKAKR 3051
Score = 46.6 bits (109), Expect = 6e-05
Identities = 81/364 (22%), Positives = 145/364 (39%), Gaps = 53/364 (14%)
Query: 54 VEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFG 113
VEE + K S +DK + K + ERK + + SE
Sbjct: 768 VEENIQKQSQQTKLSSDDKTERKSKHRN--------ERKLSVLGKDGKPVSEYIIKTDEN 819
Query: 114 PPAKNG-----VAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEE------ 162
+N ++AE + A+ ++ R + +++ S +Q + QR ES E
Sbjct: 820 VRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMD 879
Query: 163 ----------EEKGYKGKTRKKPVVKKQAPGKASVSRKQARE----ESEESEAEPVQRTA 208
EE +K K R K +++++ K S S+ Q ++ E+E E Q T
Sbjct: 880 STNMDSNLKPEEVVHKEKRRTKSLLEEKLVLK-SKSKTQGKQVKVVETELQEGATKQATT 938
Query: 209 KKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRK 268
K + K T+ E +SE++ ++ +++ EE E E + S+ R K
Sbjct: 939 PKPDKEKNTE-----ENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAK 993
Query: 269 S--AREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGG 326
A+E+ + S + RL E+K + S + +++K E+++ K G
Sbjct: 994 LPLAKEKYKSDKDSTSTRL--------ERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDG 1045
Query: 327 KRLSGSSEDEEDSGKGEPTAKGSRKMA--RLGSTSGEESDLEREVSDSEAGGGPQGERKN 384
K + SS ++ K SR++ R GS S E + E +++ + P G
Sbjct: 1046 KEVD-SSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLA-ANTLSTPSGSSLQ 1103
Query: 385 RSSK 388
R K
Sbjct: 1104 RPKK 1107
Score = 42.4 bits (98), Expect = 0.001
Identities = 62/346 (17%), Positives = 135/346 (39%), Gaps = 21/346 (6%)
Query: 40 SHLEPEE-----KQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRF 94
S+L+PEE K+ K L+EE+L+ + ++ K+ T+ + + P+ +
Sbjct: 885 SNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKE 944
Query: 95 RFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQ 154
+ E++S + S P + GV + A +S A D + LP
Sbjct: 945 KNTEENDSEKQRKSKVEDKPFEETGVEPVLETA-------SSSAHSTQKDSSHRAKLPLA 997
Query: 155 RGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVS-RKQAREESEESEAEPVQRTAKKVEG 213
+ + S+++ + + + K ++ +S +K+ +S++ + + V + +K G
Sbjct: 998 KEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARG 1057
Query: 214 NKGTKSLKESEQ--ESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAR 271
N K S + E+ L+Q+ + EE++ +P+ + +
Sbjct: 1058 NSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQ 1117
Query: 272 EERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSG--RDREPPVQRKSEDRTQLKGGKRL 329
E + + + S +++ + + DS + + +K E RT K
Sbjct: 1118 EPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKAT 1177
Query: 330 SGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAG 375
+ + + G+G S K A ST ++ ++ VS G
Sbjct: 1178 APAYK----PGRGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPG 1219
Score = 41.2 bits (95), Expect = 0.003
Identities = 89/394 (22%), Positives = 150/394 (38%), Gaps = 51/394 (12%)
Query: 56 EELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESES-----GSEASSPD 110
E+ L ++ D + D+ K G T S PE SE G+E S +
Sbjct: 2600 EQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEEGDIMVTVSSEENVCDIGNEESPLN 2659
Query: 111 YFGP---PAKNGVAAEVSPAKEEN-----PRRASKAVEESSDEERQRDLPAQRGEESSEE 162
G A + A V +E+N P + + S E QR+ ES
Sbjct: 2660 VLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPSGIAELQRE--PLLVNESLNV 2717
Query: 163 EEKGYKGKTRKKPVVKKQAPGKASVSRKQARE----ESEESEAEPVQRTAKKVEGNKGTK 218
E G++ T ++ + G+ S RK E S E++ + V+ + + K +
Sbjct: 2718 ENSGFR--TNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQ 2775
Query: 219 SLKESEQESEE--EILAQKKEQREEEVEEEE----KEEDEEKGDWKPRTRSNGRRKSAR- 271
SE E ++ ++L + E + + E E KEE+ + P+T S ++R
Sbjct: 2776 HYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRV 2835
Query: 272 ----EERSCKQKSQAKRLLGDSDS--EEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKG 325
+E S + + K D D+ +E+ + GR R+ PV+ T LK
Sbjct: 2836 MEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVE------TTLK- 2888
Query: 326 GKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNR 385
+D+ + G T + S ++L +ES+ E + GE K
Sbjct: 2889 -------MKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIV 2941
Query: 386 SSKKSSRKGRTRSSSSSSD---GSPEAKGGKAGS 416
+S + + RS + S D PE K K+ S
Sbjct: 2942 TSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVS 2975
Score = 32.0 bits (71), Expect = 1.5
Identities = 36/210 (17%), Positives = 78/210 (37%), Gaps = 8/210 (3%)
Query: 42 LEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESE 101
+E +++ + E+ + D S+E+ + K KR P P + +S+
Sbjct: 2836 MEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRG-RPRKYPVETTLKMKDDSK 2894
Query: 102 SGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEE------RQRDLPAQR 155
+ + + + P + + + +E +++ EE R+R +R
Sbjct: 2895 TDTGIVTVEQ-SPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKR 2953
Query: 156 GEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNK 215
S++ E + R+K V K S ++ EE E+ + R+ + E +
Sbjct: 2954 SLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQR 3013
Query: 216 GTKSLKESEQESEEEILAQKKEQREEEVEE 245
L S + E + + ++ VEE
Sbjct: 3014 SKTQLSPSIKRKREVSPPGARTRGQQRVEE 3043
>gi|68299795 chromodomain helicase DNA binding protein 1 [Homo
sapiens]
Length = 1710
Score = 69.3 bits (168), Expect = 9e-12
Identities = 73/305 (23%), Positives = 127/305 (41%), Gaps = 42/305 (13%)
Query: 143 SDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRK-----------Q 191
SDEE R+ GE S +++ G + + G +S S Q
Sbjct: 5 SDEESVRN---SSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSESGSQ 61
Query: 192 AREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEK--- 248
+ ES+ S VQ KV+G + KS IL ++++Q++++ +
Sbjct: 62 SESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAILKKQQQQQQQQQHQASSNSG 121
Query: 249 -EEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGR 307
EED + + S +RK ++E S + G SDSE E++ SS D++
Sbjct: 122 SEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSG-SDSESEEEREKSSCDETES 180
Query: 308 DREPP---VQRKSEDRTQLKGGKRLSG-------SSEDEEDSGKGEPTAKGSRKMARLGS 357
D EP RK ++R++ K GK++ G SSE+++D + + SR+ A +
Sbjct: 181 DYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDNDKRSSRRQATVNV 240
Query: 358 TSGEESDLEREVSDSEAGGG---PQGERKN----------RSSKKSSRKGRTRSSSSSSD 404
+ E+ +++ + D G PQ E + R +K + T + +D
Sbjct: 241 SYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEAD 300
Query: 405 GSPEA 409
G P A
Sbjct: 301 GDPNA 305
Score = 51.2 bits (121), Expect = 2e-06
Identities = 56/263 (21%), Positives = 102/263 (38%), Gaps = 35/263 (13%)
Query: 159 SSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTK 218
S EE + G++ + A G S S + + S++ + + G++
Sbjct: 5 SDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSG-------SSDSDSGSE 57
Query: 219 SLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQ 278
S +SE ES+ RE +V+ + + D + WK ++SA ++ +Q
Sbjct: 58 SGSQSESESDTS--------RENKVQAKPPKVDGAEF-WKSSPSILAVQRSAILKKQQQQ 108
Query: 279 KSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEED 338
+ Q + + EE ++ DDS + V+RK ED +
Sbjct: 109 QQQQQHQASSNSGSEEDSSSSEDSDDSSSE----VKRKKH-------------KDEDWQM 151
Query: 339 SGKGEPTAKGSRKMAR--LGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRT 396
SG G P+ GS + +S +E++ + E + PQ K+++ KK + +
Sbjct: 152 SGSGSPSQSGSDSESEEEREKSSCDETESDYEPKNKVKSRKPQNRSKSKNGKKILGQKKR 211
Query: 397 RSSSSSSDGSPEAKGGKAGSGRR 419
+ SS D E S RR
Sbjct: 212 QIDSSEEDDDEEDYDNDKRSSRR 234
Score = 36.2 bits (82), Expect = 0.081
Identities = 37/165 (22%), Positives = 67/165 (40%), Gaps = 2/165 (1%)
Query: 90 ERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEES-SDEERQ 148
++++ + + S SGSE S + E+ S + +S SD E +
Sbjct: 108 QQQQQQHQASSNSGSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSGSDSESE 167
Query: 149 RDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAR-EESEESEAEPVQRT 207
+ +E+ + E K K+RK K GK + +K+ + + SEE + E
Sbjct: 168 EEREKSSCDETESDYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDN 227
Query: 208 AKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDE 252
K+ + T ++ E E + E E+V + E+EE E
Sbjct: 228 DKRSSRRQATVNVSYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFE 272
Score = 34.7 bits (78), Expect = 0.24
Identities = 38/206 (18%), Positives = 76/206 (36%), Gaps = 22/206 (10%)
Query: 175 PVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQ 234
P K++ ++ +E E E EP + ++ T + +E+L+Q
Sbjct: 959 PFNKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQ 1018
Query: 235 KKEQREEEVEEEEKEEDEEKG--DWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSE 292
K ++E++ E + E+ +W+ + RR+ EER + + + +
Sbjct: 1019 FKVANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEER----QKELEEIYMLPRMR 1074
Query: 293 EEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKM 352
K+ + +G + R R +R SGS D GK R +
Sbjct: 1075 NCAKQISFNGSEGRRSRS----------------RRYSGSDSDSISEGKRPKKRGRPRTI 1118
Query: 353 ARLGSTSGEESDLEREVSDSEAGGGP 378
R ++++ R + + GGP
Sbjct: 1119 PRENIKGFSDAEIRRFIKSYKKFGGP 1144
Score = 29.6 bits (65), Expect = 7.6
Identities = 29/116 (25%), Positives = 50/116 (43%), Gaps = 23/116 (19%)
Query: 150 DLPAQRGEESSEEEEKGYKGKTRKKPVVKKQA-PGKASVSRKQAREESEESEAEPVQRTA 208
D P ++ + + Y K + + KK+A G S R++AR A
Sbjct: 1291 DDPDKKPQAKQLQTRADYLIKLLSRDLAKKEALSGAGSSKRRKAR--------------A 1336
Query: 209 KKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSN 264
KK NK KS+K +EEI + E+ +E++ + E K D + R++ +
Sbjct: 1337 KK---NKAMKSIKV-----KEEIKSDSSPLPSEKSDEDDDKLSESKSDGRERSKKS 1384
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 68.9 bits (167), Expect = 1e-11
Identities = 63/292 (21%), Positives = 118/292 (40%), Gaps = 48/292 (16%)
Query: 120 VAAEVSPAKEENPRRA---SKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPV 176
V EV P + + R+ S +EE+ D Q A+ +E+ EE+ K + +
Sbjct: 30 VTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQA--VAETKQEAVVEEDYNENAKNGEAKI 87
Query: 177 VKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKK 236
+ A S K+ E EE+ + ++ +K +E +A +
Sbjct: 88 TE------APASEKEIVEVKEENIEDATEKGGEK------------------KEAVAAEV 123
Query: 237 EQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQK 296
+ EE+ +E+E++++EEKG+ + + +E+++ +K + + D E+ K
Sbjct: 124 KNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGK 183
Query: 297 EAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLG 356
G + G D +++ EDR + GK E + GK KG +K +
Sbjct: 184 GNGEDGKEKGED-----EKEEEDRKETGDGK--------ENEDGK----EKGDKKEGK-- 224
Query: 357 STSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPE 408
+E + ERE + GG + K + K +G+ DG E
Sbjct: 225 DVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDGKKE 276
Score = 63.9 bits (154), Expect = 4e-10
Identities = 68/248 (27%), Positives = 102/248 (41%), Gaps = 39/248 (15%)
Query: 65 EAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSES-ESGSEASSPDYFGPPAKNGVAAE 123
EA ED + K G+ T E++ E+ E +E G K VAAE
Sbjct: 69 EAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEK------GGEKKEAVAAE 122
Query: 124 VSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPG 183
V +E+ K EE +EE+ + + +E EE+ K K K K++ G
Sbjct: 123 VKNEEEDQ-----KEDEEDQNEEK-GEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDG 176
Query: 184 KASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEV 243
K K E+ +E + K+ E K T KE+E E+ KKE ++ +V
Sbjct: 177 KKGEDGKGNGEDGKEKGED-----EKEEEDRKETGDGKENEDGKEK---GDKKEGKDVKV 228
Query: 244 EEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGD 303
+E+EKE ++ K D + EE + K+K K EEE KE +
Sbjct: 229 KEDEKEREDGKED-----------EGGNEEEAGKEKEDLK-------EEEEGKEEDEIKE 270
Query: 304 DSGRDREP 311
D G+ EP
Sbjct: 271 DDGKKEEP 278
Score = 33.5 bits (75), Expect = 0.53
Identities = 47/248 (18%), Positives = 80/248 (32%), Gaps = 58/248 (23%)
Query: 178 KKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKK- 236
K++A G+ + ++ R + S K + ++ +K EE I +
Sbjct: 3 KRKAAGQGDMRQEPKRRSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQA 62
Query: 237 --EQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEE 294
E ++E V EE+ E+ + NG K S K+ + K EE
Sbjct: 63 VAETKQEAVVEEDYNENAK----------NGEAKITEAPASEKEIVEVK--------EEN 104
Query: 295 QKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMAR 354
++A G + V+ + ED+ EDEED + +
Sbjct: 105 IEDATEKGGEKKEAVAAEVKNEEEDQ------------KEDEEDQNEEK----------- 141
Query: 355 LGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKA 414
G E+ D +GE + K + KG + KG
Sbjct: 142 -GEAGKEDKD-------------EKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGE 187
Query: 415 GSGRRGED 422
+GED
Sbjct: 188 DGKEKGED 195
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 68.9 bits (167), Expect = 1e-11
Identities = 45/194 (23%), Positives = 99/194 (51%), Gaps = 13/194 (6%)
Query: 128 KEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASV 187
+ E+ R+ + E ER+++ +RG++ ++ +K +GK R++ +++ K
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90
Query: 188 SRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEE 247
+++ + + E+ + E QR ++ K K KE E+E+++ ++K++R+++ +E
Sbjct: 91 EKERRKRKKEKKKRERKQRGRRE---RKKKKERKERERENKQRRERKRKKRRKKKRRKER 147
Query: 248 KEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGR 307
K E +E+G R R+K +EER K++ K + E E+KE + +
Sbjct: 148 KRE-KERG-----KRERKRKKRKKEEREKKRERNRK----ERKKERERKERRERKKERKK 197
Query: 308 DREPPVQRKSEDRT 321
+R +RK + +T
Sbjct: 198 ERRKKKERKKDRKT 211
Score = 61.2 bits (147), Expect = 2e-09
Identities = 39/179 (21%), Positives = 87/179 (48%), Gaps = 6/179 (3%)
Query: 152 PAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKV 211
P + E ++E + + + R++ +K+ GK +++ RE +E E + +R ++
Sbjct: 28 PCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRK 87
Query: 212 EGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAR 271
E + + ++ E++ E +++ +RE + ++E KE + E + R R R+K R
Sbjct: 88 ERREKERRKRKKEKKKRER---KQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRR 144
Query: 272 EERSCKQ---KSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGK 327
+ER ++ K + KR + E+++E R+R+ +RK E + + + K
Sbjct: 145 KERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKK 203
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/169 (21%), Positives = 82/169 (48%), Gaps = 2/169 (1%)
Query: 128 KEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASV 187
KE R K ++ ER ++ +R E + +E+ K + ++K KK+ +
Sbjct: 52 KERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGR 111
Query: 188 SRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEE 247
++ ++E +E E E QR +K + + K KE ++E E +K+++R++E E E
Sbjct: 112 RERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKE--ERE 169
Query: 248 KEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQK 296
K+ + + + K RR+ +E + ++K + ++ +D + + +
Sbjct: 170 KKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQ 218
Score = 56.6 bits (135), Expect = 6e-08
Identities = 43/201 (21%), Positives = 85/201 (42%), Gaps = 16/201 (7%)
Query: 85 PCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSD 144
PC+ E +R + E E K E +E + K +
Sbjct: 28 PCTQRESERKKERRERE---------------KRKREREKERKRERGKKEKKKRKKRERG 72
Query: 145 EERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPV 204
+ER+R + + E++ K K KK +KQ + +K+ +E E++
Sbjct: 73 KERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRE 132
Query: 205 QRTAKKVEGNKGTKSLKESEQ-ESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRS 263
++ K+ + + + +E E+ + E + +KKE+RE++ E KE +E+ + R R
Sbjct: 133 RKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERK 192
Query: 264 NGRRKSAREERSCKQKSQAKR 284
R+K R+++ K+ + R
Sbjct: 193 KERKKERRKKKERKKDRKTDR 213
Score = 55.5 bits (132), Expect = 1e-07
Identities = 44/169 (26%), Positives = 82/169 (48%), Gaps = 8/169 (4%)
Query: 189 RKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEE- 247
RK+ R E E+ + E ++ K+ G K K K+ E+ E E +++E++ +E E+E
Sbjct: 36 RKKERREREKRKRER-EKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKER 94
Query: 248 --KEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDS 305
++++++K + K R R ++K R+ER + K + +R ++ +KE +
Sbjct: 95 RKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERG 154
Query: 306 GRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMAR 354
R+R+ +RK E+R + + R E E K K RK R
Sbjct: 155 KRERKRK-KRKKEEREKKRERNRKERKKERER---KERRERKKERKKER 199
Score = 54.7 bits (130), Expect = 2e-07
Identities = 42/188 (22%), Positives = 86/188 (45%), Gaps = 7/188 (3%)
Query: 223 SEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGR-RKSAREERSCKQKSQ 281
+++ESE + +++E+R+ E E+E K E +K K + R G+ R+ R+ER ++K +
Sbjct: 30 TQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKER 89
Query: 282 AKRLLGDSDSEEEQKEAASSG------DDSGRDREPPVQRKSEDRTQLKGGKRLSGSSED 335
++ E++++E G ++RE +++ E + + + K+ +
Sbjct: 90 REKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKR 149
Query: 336 EEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGR 395
E++ GK E K +K R + ++E E + +K R KK +K R
Sbjct: 150 EKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDR 209
Query: 396 TRSSSSSS 403
+ S
Sbjct: 210 KTDRQTDS 217
Score = 38.1 bits (87), Expect = 0.021
Identities = 42/198 (21%), Positives = 82/198 (41%), Gaps = 11/198 (5%)
Query: 46 EKQALKRLVEEELLKMQVDEAASRE-DKLDLTKKGKRPPTPCSDPERKRFRFNSESESGS 104
E + K E E K + ++ RE K + K+ KR ER+R R E +
Sbjct: 33 ESERKKERREREKRKREREKERKRERGKKEKKKRKKRE----RGKERERKRKEREKQRKE 88
Query: 105 EASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGE----ESS 160
K + +E ++ K E + + R+R +R + E
Sbjct: 89 RREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERK 148
Query: 161 EEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKV-EGNKGTKS 219
E+E+G + + RKK K++ K +RK+ ++E E E ++ KK K K
Sbjct: 149 REKERGKRERKRKKR-KKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKK 207
Query: 220 LKESEQESEEEILAQKKE 237
++++++++ ++ +E
Sbjct: 208 DRKTDRQTDSQVFRPLRE 225
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 68.6 bits (166), Expect = 1e-11
Identities = 91/414 (21%), Positives = 163/414 (39%), Gaps = 69/414 (16%)
Query: 55 EEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGP 114
+ E+ ++Q A+ E T+ +P S+ E S+SE+ E P
Sbjct: 158 DSEIEELQKSPASDSE-----TEDALKPQISDSESEEPPRHQASDSEN-EEPPKPRMSDS 211
Query: 115 PAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKK 174
++ +VS ++ E P R ++SD E + +LP R +S E+ ++ +
Sbjct: 212 ESEELPKPQVSDSESEEPPR-----HQASDSENE-ELPKPRISDSESEDPPRHQASDSEN 265
Query: 175 PVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQ 234
+ K S S R ++ +SE E + + ++G + S+ E+E+ +
Sbjct: 266 EELPKPRISD-SESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHK 324
Query: 235 KKEQREEEVEEEEKEED------------------------EEKGDWKPRTRSNGRRKSA 270
+K + +++ + E K ED EE+ K + S+ K
Sbjct: 325 QKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEG 384
Query: 271 REERSCKQKSQAKRLLGDSDSEEEQKEAA------SSGDDSGRD--------REPPVQRK 316
EE+ K+K+ SDSE+E+K +A S DDS D RE +
Sbjct: 385 EEEKVAKRKAAVL-----SDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASD 439
Query: 317 SEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLE--------RE 368
SE+ + GK LS +E+D G + G+ + + GE D E +E
Sbjct: 440 SEE----EAGKELSDKKNEEKDL-FGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQE 494
Query: 369 VSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGED 422
+ E G E ++ S + ++G+ S + + K +G RR D
Sbjct: 495 DLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRD 548
Score = 64.3 bits (155), Expect = 3e-10
Identities = 80/385 (20%), Positives = 141/385 (36%), Gaps = 32/385 (8%)
Query: 64 DEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESES-----GSEASSPDYFGPPAKN 118
+E + RED L KG +D +SESE S++ S + PPA +
Sbjct: 51 NETSDREDGLP---KGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASD 107
Query: 119 GVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVK 178
+V+ ++ ++ + SD E + L + SE E+ G + +
Sbjct: 108 SENEDVNQHGSDSESEETRKLP-GSDSENEELLNGHASD--SENEDVGKHPASDSEIEEL 164
Query: 179 KQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQ 238
+++P S + + + +SE+E R N+ + S+ ESEE Q +
Sbjct: 165 QKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDS 224
Query: 239 REEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQ--------------AKR 284
EE + + E + KPR + R + S + + +
Sbjct: 225 ESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRN 284
Query: 285 LLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEP 344
DS++EE K S + G + P ++ED ++ K+ S +D + KGE
Sbjct: 285 QASDSENEELPKPRVSDSESEGPQKGPASDSETEDASR---HKQKPESDDDSDRENKGED 341
Query: 345 TAKGSRKM---ARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSS 401
T + + + SD E E + + E++ K + RK S S
Sbjct: 342 TEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSE 401
Query: 402 SSDGSPEAKGGKAGSGRRGEDHPAV 426
+ AK + S D AV
Sbjct: 402 DEE-KASAKKSRVVSDADDSDSDAV 425
Score = 56.2 bits (134), Expect = 8e-08
Identities = 92/404 (22%), Positives = 153/404 (37%), Gaps = 57/404 (14%)
Query: 56 EELLKMQVDEAASRE---DKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYF 112
+E L + ++ S E K ++ +R P SD E + ++ GS++ S +
Sbjct: 72 DEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENE-----DVNQHGSDSESEETR 126
Query: 113 GPPAK--------NGVAAEVSPAKEENPRRASKAVEE-----SSDEERQRDLPAQRGEES 159
P NG A++ + +EE +SD E + L Q +
Sbjct: 127 KLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSE 186
Query: 160 SEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKS 219
SEE + + + K + S + + ESE EP + A E N+
Sbjct: 187 SEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESE-EPPRHQASDSE-NEELPK 244
Query: 220 LKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQK 279
+ S+ ESE+ Q + EE+ + + D E D S+ + + R +
Sbjct: 245 PRISDSESEDPPRHQASDSENEEL-PKPRISDSESEDPPRNQASDSENEELPKPRVSDSE 303
Query: 280 SQAKRLLGDSDSEEE----QKEAASSGDDSGRDREPPVQRKSEDR----TQLKGGKRLSG 331
S+ + SDSE E K+ S DDS R+ + D + + K S
Sbjct: 304 SEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSS 363
Query: 332 SSEDE----------EDSGKGEPTAKGSRKMARLGSTSGEE---SDLEREVSDSEAGGGP 378
SE+E ED +GE RK A L + EE + R VSD++
Sbjct: 364 DSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDAD----- 418
Query: 379 QGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGED 422
+ S KS ++ +T +S S E + GK S ++ E+
Sbjct: 419 -DSDSDAVSDKSGKREKTIASDS------EEEAGKELSDKKNEE 455
Score = 48.1 bits (113), Expect = 2e-05
Identities = 73/356 (20%), Positives = 122/356 (34%), Gaps = 58/356 (16%)
Query: 40 SHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTP---CSDPERKRFRF 96
S E K + EEL K QV ++ S E + P SD E +
Sbjct: 198 SENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPR 257
Query: 97 NSESESGSEA------SSPDYFGPPAKNGVAAE--------VSPAKEENPRRASKAVEES 142
+ S+S +E S + PP +E VS ++ E P++ + E+
Sbjct: 258 HQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSET 317
Query: 143 SDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAE 202
D R + P ++ S+ E KG + + + + EE + +
Sbjct: 318 EDASRHKQKP--ESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKM 375
Query: 203 PVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQRE-EEVEEEEKEEDEEKGDWKPRT 261
K+ E K K +SE+E A K+ R + ++ + + +K + +T
Sbjct: 376 DSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKT 435
Query: 262 RSNGRRKSAREERSCKQKSQAKRLLGDS-------------------DSEEEQ------- 295
++ + A +E S K K++ K L G D EEE+
Sbjct: 436 IASDSEEEAGKELSDK-KNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQE 494
Query: 296 -----------KEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSG 340
KEA S D R + S+ L+ K +SG D G
Sbjct: 495 DLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGG 550
Score = 43.9 bits (102), Expect = 4e-04
Identities = 45/239 (18%), Positives = 92/239 (38%), Gaps = 25/239 (10%)
Query: 183 GKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEE 242
G+ V+ + + ++ E T+ + +G + +SE + + A E E
Sbjct: 29 GEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELH 88
Query: 243 VEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLG--------------D 288
+++ E EE+ + S+ + + S + + ++L G D
Sbjct: 89 RQKDSDSESEERAE---PPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASD 145
Query: 289 SDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKG 348
S++E+ K AS + + P ++ED + ++S S +E + +
Sbjct: 146 SENEDVGKHPASDSEIEELQKSPASDSETEDALK----PQISDSESEEPPRHQASDSENE 201
Query: 349 SRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSP 407
R+ + EE + +VSDSE+ P R S ++ + R S S S+ P
Sbjct: 202 EPPKPRMSDSESEELP-KPQVSDSESEEPP---RHQASDSENEELPKPRISDSESEDPP 256
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 68.6 bits (166), Expect = 1e-11
Identities = 111/491 (22%), Positives = 191/491 (38%), Gaps = 72/491 (14%)
Query: 43 EPEEKQALKRLV---EEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSE 99
E EEK +KRL + + + ++E R+ +++T + + P R+ +S
Sbjct: 25 EQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIR--------NSPYRRE---DSM 73
Query: 100 SESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEES 159
+ G E S PP + +V K+E + A + + E +R + ++
Sbjct: 74 EDRGEEDDSLA-IKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDK 132
Query: 160 SEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQARE----ESEESEAEPVQRTAKKVEGNK 215
+ E + K + + +++ + RK+ RE E ++ + E +R + E K
Sbjct: 133 ARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRK 192
Query: 216 GTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTR--SNGRRKSAREE 273
E+E+ E+ A + RE+ ++ + PR R RK +EE
Sbjct: 193 --------EREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEE 244
Query: 274 RSCKQKSQAKRLLGD----SDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRL 329
K + + LL D SDSE + A SS +SG E + + E+ + +G
Sbjct: 245 -----KMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEE--EEEEEEEEEEEGSTSE 297
Query: 330 SGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKK 389
E+EE+ + E T S + S E E E+S+ E ER+N +
Sbjct: 298 ESEEEEEEEEEEEEETGSNSEE----ASEQSAEEVSEEEMSEDE-------ERENENHLL 346
Query: 390 SSRKGR-TRSSSSSSDGSPEAKGGKAGSGRRGE-----DHPAV--MRLKRYIRACGAHRN 441
+ R R S S + E G S E D PA+ + LK+ +
Sbjct: 347 VVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQEL------PK 400
Query: 442 YKKLLGSCCSHKERLSILRAELEALGM------KGTPSLGKCRALK-EQREEAAEVASLD 494
Y L C S +E + R E G+ K T + + LK E+ +E + SL
Sbjct: 401 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR 460
Query: 495 VANIISGSGRP 505
N I + P
Sbjct: 461 EINTILKAQHP 471
Score = 64.3 bits (155), Expect = 3e-10
Identities = 80/417 (19%), Positives = 163/417 (39%), Gaps = 73/417 (17%)
Query: 120 VAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKK 179
+ E KE+ + K ++ S D + +RD S EE E + + +
Sbjct: 16 ILQEKKRRKEQEEKAEIKRLKNSDDRDSKRD--------SLEEGEL----RDHCMEITIR 63
Query: 180 QAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQR 239
+P + S + EE + +P Q+ ++K + K+ +++ ++ ++KE+
Sbjct: 64 NSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEK----VHHRKDEKRKEKKHARVKEKERE 119
Query: 240 EEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERS----CKQKSQAKRLLGDSDSEE-E 294
E + +E+D+ + +W+ + R R+ +R ER ++K + +R + + E+ E
Sbjct: 120 HERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQRE 179
Query: 295 QKEAASSGDDSGRDRE----------------------------PPVQRKSEDRTQLKGG 326
QKE ++ ++RE PP R +R +L G
Sbjct: 180 QKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPP--RPPRERFELGDG 237
Query: 327 KR-----------LSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAG 375
++ L +D DS + +A+ S + GS EE + E E S +
Sbjct: 238 RKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE 297
Query: 376 GGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGEDHPAVMRLKRYIRA 435
+ E + ++ + +S S++ E + + R E+H V+ R+ R
Sbjct: 298 ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE-DEERENENHLLVVPESRFDRD 356
Query: 436 CGAHRNYKKLLGSCCSHKERL----------SILRAELEALGMKGTPSLGKCRALKE 482
G ++ +G L ++ EL+ K P+L CR+++E
Sbjct: 357 SGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEE 413
Score = 58.5 bits (140), Expect = 2e-08
Identities = 76/330 (23%), Positives = 119/330 (36%), Gaps = 78/330 (23%)
Query: 26 HSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTP 85
H+ V+ + H R E+ +A + ++ +M + + D+L+
Sbjct: 110 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQL--------- 160
Query: 86 CSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDE 145
ERKR R E E + E R +A E +
Sbjct: 161 ----ERKRERERKMREQQKE----------------------QREQKERERRAEERRKER 194
Query: 146 ERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEE------- 198
E +R++ A + +K + P + + RK +EE E
Sbjct: 195 EARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSD 254
Query: 199 ----SEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEK 254
S++E +A+ G+ S +E E+E EEE E+ EEE EEEE+EE+E
Sbjct: 255 LQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEE-- 312
Query: 255 GDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQ 314
T SN S E+S ++ SEEE E D R+ E +
Sbjct: 313 ------TGSNSEEAS---EQSAEEV-----------SEEEMSE------DEERENENHLL 346
Query: 315 RKSEDRTQLKGGKRLSGSSEDEEDSGKGEP 344
E R G+ S E EE+ G+G P
Sbjct: 347 VVPESRFDRDSGE----SEEAEEEVGEGTP 372
Score = 37.0 bits (84), Expect = 0.048
Identities = 43/201 (21%), Positives = 74/201 (36%), Gaps = 7/201 (3%)
Query: 229 EEILAQKKEQREEEVEEEEKE-EDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLG 287
+EIL +KK ++E+E + E K ++ + D K + G + E + + +
Sbjct: 14 DEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSM 73
Query: 288 DSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAK 347
+ EE+ A R +E RK E R + K + E E E K
Sbjct: 74 EDRGEEDDSLAIKPPQQMSR-KEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDK 132
Query: 348 GSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSP 407
R+ R + ++ RE S E Q ERK +K + + + +
Sbjct: 133 ARREWER-----QKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRA 187
Query: 408 EAKGGKAGSGRRGEDHPAVMR 428
E + + + R H MR
Sbjct: 188 EERRKEREARREVSAHHRTMR 208
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 68.6 bits (166), Expect = 1e-11
Identities = 73/312 (23%), Positives = 117/312 (37%), Gaps = 30/312 (9%)
Query: 78 KGKRPPTPCSDPERKRFR----FNSESESGSEASSPDYFGPPAK------NGVAAEVSPA 127
K K PP S ++KR R + E E D P + GV PA
Sbjct: 965 KRKEPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPA 1024
Query: 128 K--------EENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKK 179
+ EE+ + + +ES++EE + + EE EE++ R + +
Sbjct: 1025 RPLELDSGGEEDEKESLSEEQESTEEEEEAE------EEEEEEDDDDDDSDDRDE---SE 1075
Query: 180 QAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQR 239
++S ++E + E E V K E ++S + SE ES E E
Sbjct: 1076 NDDEDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDE 1135
Query: 240 EEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAR---EERSCKQKSQAKRLLGDSDSEEEQK 296
EE V EE+EE+EE+ + ++ + EE + + A LG + + +
Sbjct: 1136 EEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIET 1195
Query: 297 EAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLG 356
EA + + EPP+ E+ + G S++ EP AK L
Sbjct: 1196 EAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLS 1255
Query: 357 STSGEESDLERE 368
E DLE E
Sbjct: 1256 PERAPEHDLEVE 1267
Score = 54.3 bits (129), Expect = 3e-07
Identities = 78/342 (22%), Positives = 122/342 (35%), Gaps = 61/342 (17%)
Query: 50 LKRLVEEELLKMQVDEAASRE-----DKLDLTKKGKRPPTPCSD------PERKRFRFNS 98
LK +++ +L + V+ A R DK + K P + P+ K +
Sbjct: 872 LKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASC 931
Query: 99 ESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEE 158
ES + Y G G+ + + R+ S D++R R P+ +E
Sbjct: 932 LLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKEPPDTTSSGDQKRLR--PSTSVDE 989
Query: 159 SSEEEEKGYKGKTRKKPV-VKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGT 217
EE E+ P + K+ P V R+ AR +S E ++
Sbjct: 990 EDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPLELDSGGEEDEK----------- 1038
Query: 218 KSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCK 277
+SL E EQES EE EEE EEEE+EED++ D R S
Sbjct: 1039 ESLSE-EQESTEE---------EEEAEEEEEEEDDDDDDSDDRDES-------------- 1074
Query: 278 QKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEE 337
++D E+ AS D+ D E V + + S S + E
Sbjct: 1075 ----------ENDDEDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSE--SSESSEFE 1122
Query: 338 DSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQ 379
S + P++ + EE + E +S A GP+
Sbjct: 1123 SSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPE 1164
Score = 46.6 bits (109), Expect = 6e-05
Identities = 56/258 (21%), Positives = 97/258 (37%), Gaps = 46/258 (17%)
Query: 178 KKQAPGKASVSRKQAREESEESEAEPVQRTAK---------------------KVEGNKG 216
KK+ KAS++ ++ E +E +P R A + G
Sbjct: 899 KKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIR 958
Query: 217 TKSLKESEQESEEEILA--QKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREER 274
S K +E + + QK+ + V+EE++E + E R R +R
Sbjct: 959 LPSFKVKRKEPPDTTSSGDQKRLRPSTSVDEEDEESERE------RDRDMADTPCELAKR 1012
Query: 275 SCK----QKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLS 330
K ++ A+ L DS EE++KE+ S +S + E + + E+
Sbjct: 1013 DPKGVGVRRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRD 1072
Query: 331 GSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKS 390
S D+ED+ E + K +E D + E + S + + SS+ S
Sbjct: 1073 ESENDDEDTALSEASEK-------------DEGDSDEEETVSIVTSKAEATSSSESSESS 1119
Query: 391 SRKGRTRSSSSSSDGSPE 408
+ + SS SSS+ E
Sbjct: 1120 EFESSSESSPSSSEDEEE 1137
>gi|157738619 smoothelin-like 1 [Homo sapiens]
Length = 512
Score = 68.6 bits (166), Expect = 1e-11
Identities = 76/313 (24%), Positives = 136/313 (43%), Gaps = 32/313 (10%)
Query: 127 AKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKT-RKKPVVKKQAPGKA 185
A+E+ ++ K E+ + D P G + EE KG GK + P + KA
Sbjct: 15 AREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEKA 74
Query: 186 SVSRKQARE-ESEESEAEPVQRTAKKVEGNK--GTKSLKESEQESEEEIL-AQKKEQREE 241
+ E + E + + V+ +++ G K LK+ + E EE + +Q+ R+E
Sbjct: 75 PAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKE 134
Query: 242 EVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSD------SEEEQ 295
E + E KE +E K T ++ ++K+ EE+ K +S K D D + EE+
Sbjct: 135 ETKSEPKEAEE-----KESTLASEKQKA--EEKEAKPESGQKADANDRDKPEPKATVEEE 187
Query: 296 KEAASSGDDSGRDRE---PPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKM 352
+S +++G+ +E P ++ +++ + + K + ED K EP ++
Sbjct: 188 DAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAV------VEDEAKAEPKEPDGKEE 241
Query: 353 ARLGSTSGEESDLEREVSDSEAG--GGPQGERKNRSSKK-SSRKGRTRSSSSSSDGSPEA 409
A+ G+ EE+D + E D+E G P E++ K+ G SS SP
Sbjct: 242 AKHGAK--EEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTG 299
Query: 410 KGGKAGSGRRGED 422
+G + G D
Sbjct: 300 EGHNLSTDGLGPD 312
Score = 65.1 bits (157), Expect = 2e-10
Identities = 101/439 (23%), Positives = 169/439 (38%), Gaps = 74/439 (16%)
Query: 86 CSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDE 145
CS R++ E + G + P A N + EE A KA+ E
Sbjct: 11 CSAEAREKM----EQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPT 66
Query: 146 E--RQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQARE--ESEESEA 201
E +Q PA+ G + + E G K +++A GK + +E E EE+
Sbjct: 67 ESGKQEKAPAEDGMSAELQGEAN--GLDEVKVESQREAGGKEDAEAELKKEDGEKEETTV 124
Query: 202 EPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRT 261
+ T +K E TKS + +E E + ++K++ E+E + E ++ + KP
Sbjct: 125 GSQEMTGRKEE----TKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEP 180
Query: 262 RSN--------------GRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGR 307
++ G+RK E S + K +A D +++ E ++A +
Sbjct: 181 KATVEEEDAKTASQEETGQRK----ECSTEPKEKAT----DEEAKAESQKAVVEDEAKAE 232
Query: 308 DREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGE-ESDLE 366
+EP + +++ G K + + E+ ED+ + EP GS S E E D+E
Sbjct: 233 PKEPDGKEEAK-----HGAKEEADAKEEAEDAEEAEP-----------GSPSEEQEQDVE 276
Query: 367 RE---------VSDSEAGGGPQGERKNRSS----KKSSRKGRTRSSSSSSDGS--PEAKG 411
+E S E P GE N S+ G+T S+S S S P++
Sbjct: 277 KEPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPP 336
Query: 412 GKAGSGRRGEDHPAVMRLKRYIRACGAHRNYKKLL-----GSCCSHKERLSILRAELEAL 466
SG + E P R+ R G +K + G+ +A A+
Sbjct: 337 ESPSSGEKKEKAPE-RRVSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAI 395
Query: 467 GMKGTPSLGKCRALKEQRE 485
G L CRA+ ++ E
Sbjct: 396 GGVKNMLLEWCRAMTKKYE 414
Score = 51.2 bits (121), Expect = 2e-06
Identities = 59/271 (21%), Positives = 108/271 (39%), Gaps = 26/271 (9%)
Query: 65 EAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESG--SEASSPDYFGPPAKNGVAA 122
EA +ED KK D E++ S+ +G E S ++ +A+
Sbjct: 101 EAGGKEDAEAELKK--------EDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLAS 152
Query: 123 EVSPA--KEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQ 180
E A KE P KA D+ + + +++ +EE G + + +P K++
Sbjct: 153 EKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEP--KEK 210
Query: 181 APGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQRE 240
A + + + Q +E++AEP + K+ E G K ++++E+E+ A+ E
Sbjct: 211 ATDEEAKAESQKAVVEDEAKAEPKEPDGKE-EAKHGAKEEADAKEEAEDAEEAEPGSPSE 269
Query: 241 EEVEEEEKEEDEEKG-------DWKPRTRSNGRRKS----AREERSCKQKSQAKRLLGDS 289
E+ ++ EKE + G +W G S + + Q S + S
Sbjct: 270 EQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPS 329
Query: 290 DSEEEQKEAASSGDDSGRDREPPVQRKSEDR 320
D + E+ SSG+ + E V + R
Sbjct: 330 DVPQSPPESPSSGEKKEKAPERRVSAPARPR 360
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 68.2 bits (165), Expect = 2e-11
Identities = 101/437 (23%), Positives = 165/437 (37%), Gaps = 54/437 (12%)
Query: 128 KEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASV 187
++E+ + K +ESS E+R+R +R + S + R PV +++ +
Sbjct: 147 QDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRR------RSSPVRRERKRSHSRS 200
Query: 188 SRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKK-----EQREEE 242
R + + S E ++T + E + K E S +IL K E +E
Sbjct: 201 PRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPS 260
Query: 243 VEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSG 302
E+ K+E +EK +PR+RS + +S RS +R S S ++ +
Sbjct: 261 PEKNSKKE-KEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRR 319
Query: 303 DDSGRDREPP---------VQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEP-------TA 346
S R R PP + +S R + + LSGSS S P T+
Sbjct: 320 RPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTS 379
Query: 347 KGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGS 406
RK RL S S R S P K R S + RTR S S S
Sbjct: 380 SPPRKTRRL---SPSASPPRRRHRPSPPATPPP---KTRHSPTPQQSNRTRKSRVSV--S 431
Query: 407 PEAKGGKA--GSGRRGEDHPAVMRLKRYIRACGAHRNYKKLLGSCCSHKERLSILRAELE 464
P GK G + P+ R + + + + + S ++R R +
Sbjct: 432 PGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQ 491
Query: 465 ALGMKGTPSLGKCRALKEQREEAAEVASLDVANIISGSGRPRRRTAWNPLGEAAP-PGEL 523
+ G+ S + +++R + + V + +V GR RR +P A+P P +
Sbjct: 492 SSSDSGSSS-----SSEDERPKRSHVKNGEV-------GRRRRH---SPSRSASPSPRKR 536
Query: 524 YRRTLDSDEERPRPAPP 540
+ T R P+PP
Sbjct: 537 QKETSPRGRRRRSPSPP 553
Score = 49.7 bits (117), Expect = 7e-06
Identities = 98/497 (19%), Positives = 172/497 (34%), Gaps = 102/497 (20%)
Query: 3 REKEMQEF-----TRSFFRGRPDLSTLTHSIVRRRYLAHSGRSHLEPEEKQALKRLVEEE 57
+EKE ++ +RS R R + +H+ RRR+ + S RS+ P + + +R
Sbjct: 267 KEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRS-RSY-SPRRRPSPRR----- 319
Query: 58 LLKMQVDEAASREDKLDLTKKGKRPPTP----CSDPERKRFRFNSE-SESGSEASSPDYF 112
R T + PP P P R+R R ++ S S S +SS
Sbjct: 320 -----------RPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSR 368
Query: 113 GPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLP---AQRGEESSEEEEKGYKG 169
PP K P + +P R ++ + S+ R+R P A ++
Sbjct: 369 SPPKK-------PPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSN 421
Query: 170 KTRKKPVVKKQAPGKAS--VSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQES 227
+TRK V +PG+ S V++ + E+ E P R KVE L ESE++
Sbjct: 422 RTRKSRV--SVSPGRTSGKVTKHKGTEKRESPSPAPKPR---KVE-------LSESEEDK 469
Query: 228 EEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLG 287
++ A Q+ + + ++ + G +R + +++ +
Sbjct: 470 GGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSA 529
Query: 288 DSDSEEEQKEAASSGDDSGRDREPPVQRKSED------------------RTQLKGGKRL 329
+ QKE + G PP +R+ RT +R
Sbjct: 530 SPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRR 589
Query: 330 SGS-----------------------SEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLE 366
S S S + P+ R+++ S +
Sbjct: 590 SPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVT 649
Query: 367 REVSDSEAGGGPQGERKNRS---------SKKSSRKGRTRSSSSSSDGSPEAKGGKAGSG 417
+ S S + +G +RS +K+ S R R+ +SS P +G +
Sbjct: 650 KRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQ 709
Query: 418 RRGEDHPAVMRLKRYIR 434
RR P+ ++R R
Sbjct: 710 RRQSPSPSTRPIRRVSR 726
Score = 45.4 bits (106), Expect = 1e-04
Identities = 44/188 (23%), Positives = 80/188 (42%), Gaps = 3/188 (1%)
Query: 224 EQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAK 283
+++ E+E LA K+Q +E+ ++ +KEE E + + R+RS RRKS R ++ S +
Sbjct: 133 QRQIEQEKLASMKKQ-DEDKDKRDKEEKESSREKRERSRSPRRRKS-RSPSPRRRSSPVR 190
Query: 284 RLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLK-GGKRLSGSSEDEEDSGKG 342
R S S + S +++ E ++K + + S+ D K
Sbjct: 191 RERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKP 250
Query: 343 EPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSS 402
EP + S +E + R S S + + ++ S + R+ R+RS S S
Sbjct: 251 EPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYS 310
Query: 403 SDGSPEAK 410
P +
Sbjct: 311 PRRRPSPR 318
Score = 39.3 bits (90), Expect = 0.010
Identities = 79/395 (20%), Positives = 134/395 (33%), Gaps = 64/395 (16%)
Query: 80 KRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRR----- 134
K+PP S P RK R + + P PPA SP +++ R
Sbjct: 372 KKPPKRTSSPPRKTRRLSPSASPPRRRHRPS---PPATPPPKTRHSPTPQQSNRTRKSRV 428
Query: 135 -------ASKAVEESSDEERQRDLPA---QRGEESSEEEEKGYKGKTRKKPVVKKQAPGK 184
+ K + E+R+ PA ++ E S EE+KG K ++Q +
Sbjct: 429 SVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQ 488
Query: 185 ASVSRKQAREESEESEAEPVQRTAKKVEGNKG-----TKSLKESEQESEEEILAQKKEQR 239
S + S + P + K E + ++S S ++ ++E + + +R
Sbjct: 489 NQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRR 548
Query: 240 EEEVEEEEKEEDEEKG------------------DWKPRTRS-NGRRKSAREERSCKQKS 280
+ PR RS + RR S +R
Sbjct: 549 SPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSP 608
Query: 281 QAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKG----GKRLSGSSEDE 336
KR +++ + S PP +++S T+ + K GSS
Sbjct: 609 PPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSR 668
Query: 337 E--DSGKGEPTAKGS---RKMARLGSTS------GEESDLEREVSDSEA-------GGGP 378
++ +P + S R A S+S G S +R S S + P
Sbjct: 669 STREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTP 728
Query: 379 QGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGK 413
+ ++ +++ S + R SSS S GSPE K
Sbjct: 729 EPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKK 763
Score = 35.4 bits (80), Expect = 0.14
Identities = 42/182 (23%), Positives = 73/182 (40%), Gaps = 12/182 (6%)
Query: 77 KKGKRPPTP-----CSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEEN 131
++ R P P + P + R S S S S + P PPA SP+ +
Sbjct: 722 RRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWS 781
Query: 132 PR---RASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVS 188
P + +K+ S R D Q G ++++K K K KK K+ + +V+
Sbjct: 782 PAVPVKKAKSPTPSPSPPRNSD---QEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVA 838
Query: 189 RKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEK 248
A + + A A++ E + KE+E E+E+ + +K RE+ + K
Sbjct: 839 AAAAAAVTPAAIAAATTTLAQE-EPVAAPEPKKETESEAEDNLDDLEKHLREKALRSMRK 897
Query: 249 EE 250
+
Sbjct: 898 AQ 899
Score = 34.3 bits (77), Expect = 0.31
Identities = 42/212 (19%), Positives = 77/212 (36%), Gaps = 25/212 (11%)
Query: 51 KRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPC-------SDPERKRFRFNSESESG 103
KR V Q ++ L+ K ++ +P S KR + +
Sbjct: 632 KRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAP 691
Query: 104 SEASSPDYFGPPAKNGVAAEVSPAKEENP-------RRASKAVEESSDEERQRDLPAQRG 156
+SSP PP + G ++ SP + ++P RR S+ E ++ P
Sbjct: 692 QTSSSP----PPVRRGASS--SPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVR 745
Query: 157 EESSEEEEKGYKGKTRKKPV-----VKKQAPGKASVSRKQAREESEESEAEPVQRTAKKV 211
SS G KKP V+ Q+P ++ + + R + +
Sbjct: 746 RVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQE 805
Query: 212 EGNKGTKSLKESEQESEEEILAQKKEQREEEV 243
G K K K+ + + +++ KK ++E+ V
Sbjct: 806 GGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAV 837
Score = 33.5 bits (75), Expect = 0.53
Identities = 75/393 (19%), Positives = 136/393 (34%), Gaps = 75/393 (19%)
Query: 60 KMQVDEAASREDKLDLTK----KGKRPPTPCSDPERKRFRFN---SESESGSEASSPDYF 112
K + A + K++L++ KG + S +R+++R S S+SGS +SS D
Sbjct: 447 KRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDE- 505
Query: 113 GPPAKNGVAAEVSPAKEENPRRAS-----KAVEESSDEERQRDLPA-------------- 153
P + EV + +P R++ K +E+S R+R P+
Sbjct: 506 RPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAP 565
Query: 154 ------------QRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEA 201
+R S + + P+ ++ +P R + + A
Sbjct: 566 PPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRA 625
Query: 202 EPVQRTAKKVEGNKGTKSLKESEQESEEEILAQK--------KEQREEEVEEEEKEEDEE 253
P ++V + K + L+ K + RE + K
Sbjct: 626 SPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPS 685
Query: 254 KGDWKPRTRSN------GRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGR 307
P+T S+ G S + +S ++ R + + ++ K+AAS S
Sbjct: 686 PRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQS-- 743
Query: 308 DREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGST--------S 359
V+R S R+ +SGS E P+ S+ + S S
Sbjct: 744 -----VRRVSSSRS-------VSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKS 791
Query: 360 GEESDLEREVSDSEAGGGPQGERKNRSSKKSSR 392
S SD E GG + ++K++ KK +
Sbjct: 792 PTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKK 824
>gi|221316599 chromogranin B precursor [Homo sapiens]
Length = 677
Score = 67.8 bits (164), Expect = 3e-11
Identities = 105/479 (21%), Positives = 168/479 (35%), Gaps = 49/479 (10%)
Query: 34 LAHSGRSHLEPEEKQALK---------RLVEEELLKMQVDEAASREDKLDLTKKGKRPPT 84
L+ S + PE +Q LK E E K +V D + + R
Sbjct: 45 LSKSSAPPITPECRQVLKTSRKDVKDKETTENENTKFEVRLLRDPADASEAHESSSRGEA 104
Query: 85 PCSDPERKRFRFNSESESGSE--------ASSPDYFGPPAKNGVAAEVSPAKEENPRRAS 136
E + +++E +E A P + P+ + V+ EV E +R
Sbjct: 105 GAPGEEDIQGPTKADTEKWAEGGGHSRERADEPQWSLYPSDSQVSEEVKTRHSEKSQR-- 162
Query: 137 KAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREES 196
E+ +EE + +RGE+SSEE+ G+T+ + +++ +AS +K+ E
Sbjct: 163 ---EDEEEEEGENYQKGERGEDSSEEKHLEEPGETQNAFLNERK---QASAIKKE--ELV 214
Query: 197 EESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGD 256
SE + +K + + E S+E + K Q + E EE EED
Sbjct: 215 ARSETHAAGHSQEKTHSREKSSQESGEETGSQENHPQESKGQPRSQEESEEGEEDATSEV 274
Query: 257 WKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRK 316
K RTR +R +RS + S G E E+ + + RD R
Sbjct: 275 DKRRTRPRHHHGRSRPDRSSQGGSLPSEEKGHPQEESEESNVSMASLGEKRDHHSTHYRA 334
Query: 317 SEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGG 376
SE+ + EE G A + R EE R S+
Sbjct: 335 SEEEPEY-----------GEEIKGYPGVQAPEDLEWERYRGRGSEEYRAPRPQSEE---S 380
Query: 377 GPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGEDHPAVM---RLKRYI 433
+ +++N S + + S + E G+ GR GE M R ++
Sbjct: 381 WDEEDKRNYPSLELDKMAHGYGEESEEERGLEPGKGRHHRGRGGEPRAYFMSDTREEKRF 440
Query: 434 RACGAHRNYKKLLGSCCSHKE-RLSILRAELEALGMKGTP----SLGKCRALKEQREEA 487
G HR + + H + L G +G P G + KE REEA
Sbjct: 441 LGEGHHRVQENQMDKARRHPQGAWKELDRNYLNYGEEGAPGKWQQQGDLQDTKENREEA 499
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 67.8 bits (164), Expect = 3e-11
Identities = 91/443 (20%), Positives = 177/443 (39%), Gaps = 48/443 (10%)
Query: 3 REKEMQEFTRSFFRGRPDLSTLTHSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLKMQ 62
R+K +QE P ++ + S+ RR + + +E+++ R E+ + +
Sbjct: 107 RQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETE 166
Query: 63 VDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEA--------SSPDYFGP 114
+ +++ ++ K+ + E ++ + S E+ E S +
Sbjct: 167 TVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVM 226
Query: 115 PAKNGVAAEVSPAKEENPRRASKAV--EESSDEERQRDLPAQRGEESSEEEEKGYKGKTR 172
KNG + P +EE + S + E +EE + A+R +EE E+ K +
Sbjct: 227 SLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERER-IKAEQD 285
Query: 173 KKPVVKK---QAPGKASVSRKQARE--------ESEESEAEPVQRTAKKVE-GNKGTKSL 220
KK ++ +A KA+ ++ RE E E+ AE QR ++ + + + +
Sbjct: 286 KKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRI 345
Query: 221 KESEQESEEE---ILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCK 277
KE E+ + EE I ++K EE +EE++ K + + R + +K A +E K
Sbjct: 346 KEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIK 405
Query: 278 QKSQAKRLLG----DSDSEEEQKEAA---SSGDDSGRDREPPVQRKSEDRTQLK----GG 326
+ +++ G + ++E++ + A G++ G + ++ ED+ K
Sbjct: 406 GEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKD 465
Query: 327 KRLSGSSEDEE------DSGKGEPTAKGSRKMARLGSTSGEESDLER-----EVSDSEAG 375
+++ E +E D KG K E+ R V EA
Sbjct: 466 EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAE 525
Query: 376 GGPQGERKNRSSKKSSRKGRTRS 398
G PQ E R + R+G T S
Sbjct: 526 GAPQVEAGKRLEELRRRRGETES 548
Score = 51.6 bits (122), Expect = 2e-06
Identities = 68/277 (24%), Positives = 120/277 (43%), Gaps = 35/277 (12%)
Query: 39 RSHLEPEEKQALKRLVEEELLKMQVDEA--ASREDKLDLTKKGKRPPTPCSDPERKRFRF 96
R+ E EEK VEE+ Q++E A +E K+ KG++ E K
Sbjct: 372 RARAEEEEKAK----VEEQKRNKQLEEKKHAMQETKI----KGEKVEQKI---EGKWVNE 420
Query: 97 NSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRG 156
E + + G V A+ +E+ P EE DE+ ++D +
Sbjct: 421 KKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKK---EEIKDEKIKKDKEPKEE 477
Query: 157 EESSEEEEKGYKG-----------KTRKKPVVKKQAPGKASVSRKQAREESEESEA---- 201
+S + +KG+ K + + G+ASV K+A E + + EA
Sbjct: 478 VKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEA-EGAPQVEAGKRL 536
Query: 202 EPVQRTAKKVEGNKGTKSLKESEQES--EEEILAQKKEQREEEVEEEEKEEDEEKGDWKP 259
E ++R + E + K LK+ +QE+ E E L +K+E+R + +EEEE+ +E+ D K
Sbjct: 537 EELRRRRGETESEEFEK-LKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 595
Query: 260 RTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQK 296
R RR ER + ++ ++ + + +++K
Sbjct: 596 REEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 632
Score = 47.4 bits (111), Expect = 4e-05
Identities = 57/290 (19%), Positives = 114/290 (39%), Gaps = 24/290 (8%)
Query: 123 EVSPAKEENPRRASKAVEESSDEERQRDLPAQR--GEESSEEEEKGYKGKTRKKPVVKKQ 180
E A+E R + + + +EE + Q ++S +E+ T + +
Sbjct: 34 EEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 93
Query: 181 APGKASVSRKQAREESEESEAEPVQR----TAKKVEGNKGTKSLKESEQESEEEILAQKK 236
A ++R++ R + EA Q+ T + ++ ++ E+E +K
Sbjct: 94 AAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKS 153
Query: 237 EQREEEVEEEEKE---EDEEKGDWKPRTRSNGRRKSAREERSCKQK------SQAKRLLG 287
E R+E E EE E + +K DW+ + K EE K K +Q + ++
Sbjct: 154 ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVE 213
Query: 288 DSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAK 347
+ +E +++ S + E P ++ E+R Q G +S + EE E +
Sbjct: 214 EKTTESQEETVVMSLKNGQISSEEP--KQEEEREQ--GSDEISHHEKMEE-----EDKER 264
Query: 348 GSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTR 397
+ ARL + E E++ ++ + E K + ++ R+ R
Sbjct: 265 AEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEER 314
Score = 43.1 bits (100), Expect = 7e-04
Identities = 71/322 (22%), Positives = 119/322 (36%), Gaps = 54/322 (16%)
Query: 144 DEERQRDLPAQRGEESSEEEEK-GYKGKTRKKPVVKKQAPGKASVSRKQAREESEE---- 198
D ER+R+L Q+ EE E E+ Y+ + ++ +A R + ++E E
Sbjct: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV 62
Query: 199 -SEAEPVQRTAKKVEGNKGTKSLKESEQESEE---EILAQKKEQRE---EEVEEEEKEED 251
+ E + + E K T + + E + E E LA+++E+R+ +E E +KE D
Sbjct: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD 122
Query: 252 EEKGD----WKPRTRSNGRRKSAREERSCKQKSQAKRL---------------------- 285
D R N ++ E+ K +S+ +R
Sbjct: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEE 182
Query: 286 --LGDSDSEEEQKEAASSGDDSGRDREPPVQRK---SEDRT---QLKGGKRLSGSSEDEE 337
D + EEE++E G E V+ K S++ T LK G+ S + EE
Sbjct: 183 NKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEE 242
Query: 338 DSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTR 397
+ +G KM EE D ER ++ + ER K R R
Sbjct: 243 EREQGSDEISHHEKM--------EEEDKERAEAERARLEAEERERIKAEQDKKIADERAR 294
Query: 398 SSSSSSDGSPEAKGGKAGSGRR 419
+ + E + +A R
Sbjct: 295 IEAEEKAAAQERERREAEERER 316
Score = 38.1 bits (87), Expect = 0.021
Identities = 79/403 (19%), Positives = 144/403 (35%), Gaps = 70/403 (17%)
Query: 54 VEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFG 113
VE+++ V+E ++EDKL K+ + + KR + +
Sbjct: 409 VEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDK------------- 455
Query: 114 PPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGE---ESSEEEEKGYKGK 170
P K + K++ P+ K+ + ++ ++ +Q GE + E +
Sbjct: 456 PTFKKEEIKDEKIKKDKEPKEEVKSFMDR--KKGFTEVKSQNGEFMTHKLKHTENTFSRP 513
Query: 171 TRKKPVVKKQAPGKASVS---------RKQAREESEESEAEPVQRTAKKVEGNKGTKSLK 221
+ V K+A G V R++ ESEE E ++ +E + K +
Sbjct: 514 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 573
Query: 222 ESEQESEEEILAQKKEQREEEVEEEEKE----------------------EDEEKGDWKP 259
E + EEE +K+E+ + ++ EEE++ ED D KP
Sbjct: 574 ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKP 633
Query: 260 -------------RTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSG 306
R+ KS ++ K QA ++ DS EQ +A G S
Sbjct: 634 FKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQA-AIVSKIDSRLEQYTSAIEGTKSA 692
Query: 307 RDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLE 366
+ +P S+ +G + + S E+ + PTA G+ G G S +
Sbjct: 693 KPTKPAA---SDLPVPAEGVRNI--KSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRIN 747
Query: 367 REVSDSEAGGGPQGERKN--RSSKKSSRKGRTRSSSSSSDGSP 407
++ + G + + R SS++ S SP
Sbjct: 748 EWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSP 790
Score = 33.9 bits (76), Expect = 0.40
Identities = 42/225 (18%), Positives = 83/225 (36%), Gaps = 6/225 (2%)
Query: 206 RTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNG 265
R K+ E + + + +EE A+++ +R + +K+E+E G + N
Sbjct: 11 RRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNA 70
Query: 266 RRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKG 325
+ EE K + ++ GD ++ ++ A R +E ++K D T
Sbjct: 71 QNSVPDEE--AKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDA 128
Query: 326 GKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNR 385
L S + D+ + E T K + +R EE++ V+ S + +N+
Sbjct: 129 SLSLP-SRRMQNDTAENETTEKEEKSESRQERYEIEETE---TVTKSYQKNDWRDAEENK 184
Query: 386 SSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGEDHPAVMRLK 430
K + S G + + ++ VM LK
Sbjct: 185 KEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLK 229
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 67.8 bits (164), Expect = 3e-11
Identities = 111/472 (23%), Positives = 182/472 (38%), Gaps = 89/472 (18%)
Query: 55 EEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGP 114
E++ L ++ + SR++K+ K KR E++R R +S
Sbjct: 45 EDDSLAIKPPQQMSRKEKVHHRKDEKRK-------EKRRHRSHS---------------- 81
Query: 115 PAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKK 174
A+ G A V + E+ RR K E D+ R R+ Q+ E + E + + +
Sbjct: 82 -AEGGKHARVKEKEREHERR--KRHREEQDKAR-REWERQKRREMAREHSRRERDRL--- 134
Query: 175 PVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQ 234
+Q K RK ++ E+ E + +R A++ + E+E+ E+ A
Sbjct: 135 ----EQLERKRERERKMREQQKEQREQKERERRAEE----------RRKEREARREVSAH 180
Query: 235 KKEQREEEVEEEEKEEDEEKGDWKPRTR--SNGRRKSAREERSCKQKSQAKRLLGD---- 288
+ RE+ ++ + PR R RK +EE K + + LL D
Sbjct: 181 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEE-----KMEERDLLSDLQDI 235
Query: 289 SDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKG 348
SDSE + A SS +SG E + + E+ + +G E+EE+ + E T
Sbjct: 236 SDSERKTSSAESSSAESGSGSEE--EEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSN 293
Query: 349 SRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGR-TRSSSSSSDGSP 407
S + S E E E+S+ E ER+N + + R R S S +
Sbjct: 294 SEE----ASEQSAEEVSEEEMSEDE-------ERENENHLLVVPESRFDRDSGESEEAEE 342
Query: 408 EAKGGKAGSGRRGE-----DHPAV--MRLKRYIRACGAHRNYKKLLGSCCSHKERLSILR 460
E G S E D PA+ + LK+ + Y L C S +E + R
Sbjct: 343 EVGEGTPQSSALTEGDYVPDSPALSPIELKQEL------PKYLPALQGCRSVEEFQCLNR 396
Query: 461 AELEALGM------KGTPSLGKCRALK-EQREEAAEVASLDVANIISGSGRP 505
E G+ K T + + LK E+ +E + SL N I + P
Sbjct: 397 IEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 448
Score = 59.3 bits (142), Expect = 9e-09
Identities = 78/405 (19%), Positives = 155/405 (38%), Gaps = 76/405 (18%)
Query: 139 VEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEE 198
+ +S D + +RD S EE E + + + + +P + S + EE +
Sbjct: 1 MSQSDDRDSKRD--------SLEEGEL----RDHRMEITIRNSPYRREDSMEDRGEEDDS 48
Query: 199 SEAEPVQRTAKKV-------EGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEED 251
+P Q+ ++K E K + + E + ++KE+ E + +E+D
Sbjct: 49 LAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQD 108
Query: 252 EEKGDWKPRTRSNGRRKSAREER----SCKQKSQAKRLLGDSDSEE-EQKEAASSGDDSG 306
+ + +W+ + R R+ +R ER ++K + +R + + E+ EQKE ++
Sbjct: 109 KARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERR 168
Query: 307 RDRE----------------------------PPVQRKSEDRTQLKGGKR---------- 328
++RE PP R +R +L G++
Sbjct: 169 KEREARREVSAHHRTMREDYSDKVKASHWSRSPP--RPPRERFELGDGRKPVKEEKMEER 226
Query: 329 -LSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSS 387
L +D DS + +A+ S + GS EE + E E S + + E +
Sbjct: 227 DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEE 286
Query: 388 KKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGEDHPAVMRLKRYIRACGAHRNYKKLLG 447
++ + +S S++ E + + R E+H V+ R+ R G ++ +G
Sbjct: 287 EEETGSNSEEASEQSAEEVSEEEMSE-DEERENENHLLVVPESRFDRDSGESEEAEEEVG 345
Query: 448 SCCSHKERL----------SILRAELEALGMKGTPSLGKCRALKE 482
L ++ EL+ K P+L CR+++E
Sbjct: 346 EGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEE 390
Score = 58.5 bits (140), Expect = 2e-08
Identities = 76/330 (23%), Positives = 119/330 (36%), Gaps = 78/330 (23%)
Query: 26 HSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTP 85
H+ V+ + H R E+ +A + ++ +M + + D+L+
Sbjct: 87 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQL--------- 137
Query: 86 CSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDE 145
ERKR R E E + E R +A E +
Sbjct: 138 ----ERKRERERKMREQQKE----------------------QREQKERERRAEERRKER 171
Query: 146 ERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEE------- 198
E +R++ A + +K + P + + RK +EE E
Sbjct: 172 EARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSD 231
Query: 199 ----SEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEK 254
S++E +A+ G+ S +E E+E EEE E+ EEE EEEE+EE+E
Sbjct: 232 LQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEE-- 289
Query: 255 GDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQ 314
T SN S E+S ++ SEEE E D R+ E +
Sbjct: 290 ------TGSNSEEAS---EQSAEEV-----------SEEEMSE------DEERENENHLL 323
Query: 315 RKSEDRTQLKGGKRLSGSSEDEEDSGKGEP 344
E R G+ S E EE+ G+G P
Sbjct: 324 VVPESRFDRDSGE----SEEAEEEVGEGTP 349
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 67.8 bits (164), Expect = 3e-11
Identities = 78/369 (21%), Positives = 149/369 (40%), Gaps = 37/369 (10%)
Query: 131 NPRRASKAVEESSDEERQRDL--PAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVS 188
+P R ++E+ +E+ + P Q + K K K +K VK++ +
Sbjct: 31 SPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKE--REHER 88
Query: 189 RKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQ-----ESEEEILAQKKEQREEEV 243
RK+ REE +++ E ++ +++ + EQ E E ++ Q+KEQRE+
Sbjct: 89 RKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ-- 146
Query: 244 EEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGD 303
+E E+ +E + + + R + ++ RE+ S K K+ S
Sbjct: 147 KERERRAEERRKEREARREVSAHHRTMREDYSDKVKA--------SHWSRSPPRPPRERF 198
Query: 304 DSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEES 363
+ G R+P + K E+R L +D DS + +A+ S + GS EE
Sbjct: 199 ELGDGRKPVKEEKMEERD-------LLSDLQDISDSERKTSSAESSSAESGSGSEEEEEE 251
Query: 364 DLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGEDH 423
+ E E S + + E + ++ + +S S++ E + + R E+H
Sbjct: 252 EEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE-DEERENENH 310
Query: 424 PAVMRLKRYIRACGAHRNYKKLLGSCCSHKERL----------SILRAELEALGMKGTPS 473
V+ R+ R G ++ +G L ++ EL+ K P+
Sbjct: 311 LLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPA 370
Query: 474 LGKCRALKE 482
L CR+++E
Sbjct: 371 LQGCRSVEE 379
Score = 64.7 bits (156), Expect = 2e-10
Identities = 98/437 (22%), Positives = 164/437 (37%), Gaps = 57/437 (13%)
Query: 94 FRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPA 153
+R E E PP + +V K+E + A + + E +R
Sbjct: 33 YRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRH 92
Query: 154 QRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQARE----ESEESEAEPVQRTAK 209
+ ++ + E + K + + +++ + RK+ RE E ++ + E +R +
Sbjct: 93 REEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERR 152
Query: 210 KVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTR--SNGRR 267
E K E+E+ E+ A + RE+ ++ + PR R R
Sbjct: 153 AEERRK--------EREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGR 204
Query: 268 KSAREERSCKQKSQAKRLLGD----SDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQL 323
K +EE K + + LL D SDSE + A SS +SG E + + E+ +
Sbjct: 205 KPVKEE-----KMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEE--EEEEEEEEEE 257
Query: 324 KGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERK 383
+G E+EE+ + E T S + S E E E+S+ E ER+
Sbjct: 258 EGSTSEESEEEEEEEEEEEEETGSNSEE----ASEQSAEEVSEEEMSEDE-------ERE 306
Query: 384 NRSSKKSSRKGR-TRSSSSSSDGSPEAKGGKAGSGRRGE-----DHPAV--MRLKRYIRA 435
N + + R R S S + E G S E D PA+ + LK+ +
Sbjct: 307 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQEL-- 364
Query: 436 CGAHRNYKKLLGSCCSHKERLSILRAELEALGM------KGTPSLGKCRALK-EQREEAA 488
Y L C S +E + R E G+ K T + + LK E+ +E
Sbjct: 365 ----PKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF 420
Query: 489 EVASLDVANIISGSGRP 505
+ SL N I + P
Sbjct: 421 PITSLREINTILKAQHP 437
Score = 58.5 bits (140), Expect = 2e-08
Identities = 76/330 (23%), Positives = 119/330 (36%), Gaps = 78/330 (23%)
Query: 26 HSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTP 85
H+ V+ + H R E+ +A + ++ +M + + D+L+
Sbjct: 76 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQL--------- 126
Query: 86 CSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDE 145
ERKR R E E + E R +A E +
Sbjct: 127 ----ERKRERERKMREQQKE----------------------QREQKERERRAEERRKER 160
Query: 146 ERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEE------- 198
E +R++ A + +K + P + + RK +EE E
Sbjct: 161 EARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSD 220
Query: 199 ----SEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEK 254
S++E +A+ G+ S +E E+E EEE E+ EEE EEEE+EE+E
Sbjct: 221 LQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEE-- 278
Query: 255 GDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQ 314
T SN S E+S ++ SEEE E D R+ E +
Sbjct: 279 ------TGSNSEEAS---EQSAEEV-----------SEEEMSE------DEERENENHLL 312
Query: 315 RKSEDRTQLKGGKRLSGSSEDEEDSGKGEP 344
E R G+ S E EE+ G+G P
Sbjct: 313 VVPESRFDRDSGE----SEEAEEEVGEGTP 338
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 67.4 bits (163), Expect = 3e-11
Identities = 47/227 (20%), Positives = 100/227 (44%), Gaps = 5/227 (2%)
Query: 115 PAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKK 174
P G+ A ++ +R V E +++ER RD R E +E+E K+
Sbjct: 60 PRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDR-ERRRKEKETNRNRDREKQ 118
Query: 175 PVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQ 234
+++ + R++ R+ E E + + ++ + K +E+E E E + +
Sbjct: 119 TEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDRERE 178
Query: 235 KKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEE 294
K+++RE E + +++ D EK + R R++ + ER + + +R ++D E
Sbjct: 179 KQKERETE-RDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGER---ETDRRRE 234
Query: 295 QKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGK 341
++ G + R+R+ +RK E + + K ++ E + K
Sbjct: 235 RQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKK 281
Score = 59.3 bits (142), Expect = 9e-09
Identities = 45/218 (20%), Positives = 98/218 (44%), Gaps = 12/218 (5%)
Query: 189 RKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEK 248
R + RE++E+ +R ++ K T ++ E+++E E +++ E+ + E+
Sbjct: 81 RDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIE-----RDREREKQKGRER 135
Query: 249 EEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSE-EEQKEAASSGDDSGR 307
E D + + R R R + ++R +++++ +R + D E E+QKE + D R
Sbjct: 136 ERDRGRERERDRDREKERERQTEKDRDGQRETETER---ERDREREKQKERETERD---R 189
Query: 308 DREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLER 367
DR+ +++ E +T + ++ +E + ++ + R+ + G+E D ER
Sbjct: 190 DRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRER 249
Query: 368 EVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDG 405
+ + + +K R KK K R +G
Sbjct: 250 DRKEERKKERKKERKKERKEKKKEEKRREDKKRKWGEG 287
Score = 55.8 bits (133), Expect = 1e-07
Identities = 41/183 (22%), Positives = 82/183 (44%), Gaps = 10/183 (5%)
Query: 128 KEENPRR-ASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKAS 186
KE N R K E D ER++ +R + E E+ + ++ +K G+
Sbjct: 107 KETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRE 166
Query: 187 VS----RKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEE 242
R + RE+ +E E E + + E + ++ +E +++ + + Q++ RE E
Sbjct: 167 TETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGE 226
Query: 243 VEEE---EKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAA 299
E + E++ D ++G K R R R++ ++ER ++K + K + E++K
Sbjct: 227 RETDRRRERQRDRDRG--KERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKKRKW 284
Query: 300 SSG 302
G
Sbjct: 285 GEG 287
Score = 52.4 bits (124), Expect = 1e-06
Identities = 43/218 (19%), Positives = 92/218 (42%), Gaps = 22/218 (10%)
Query: 39 RSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNS 98
R E E + KR E + + + RE + ++ + +R ER+R R
Sbjct: 85 REKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQ--KGRERERDRGRE 142
Query: 99 ESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEE 158
+ ++G + + + R K E D +RQRD +R +
Sbjct: 143 RERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQ 202
Query: 159 SSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTK 218
+ E ++ K +T ++ RE E E E +R ++ + ++G +
Sbjct: 203 TDRERDRQRKTQTERQ------------------RETDREGERETDRRRERQRDRDRGKE 244
Query: 219 SLKESEQESE--EEILAQKKEQREEEVEEEEKEEDEEK 254
+E +++ E +E ++K++R+E+ +EE++ ED+++
Sbjct: 245 RDRERDRKEERKKERKKERKKERKEKKKEEKRREDKKR 282
Score = 45.4 bits (106), Expect = 1e-04
Identities = 50/224 (22%), Positives = 84/224 (37%), Gaps = 21/224 (9%)
Query: 209 KKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRK 268
K +G+ + +++E+E +K RE +E+E + ++ R R K
Sbjct: 70 KDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREK 129
Query: 269 SAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKR 328
ER + + +R D D E+E++ D R+ E +R DR + K +R
Sbjct: 130 QKGRERERDRGRERER---DRDREKERERQTEKDRDGQRETETERER---DREREKQKER 183
Query: 329 LSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGE-----------ESDLERE-VSDSEAGG 376
+ D + + E + R+ R T E E+D RE D + G
Sbjct: 184 ETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGK 243
Query: 377 GPQGERKNRSSKKSSRK---GRTRSSSSSSDGSPEAKGGKAGSG 417
ER + +K RK + R + E K K G G
Sbjct: 244 ERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKKRKWGEG 287
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.303 0.123 0.332
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,050,416
Number of Sequences: 37866
Number of extensions: 1441433
Number of successful extensions: 42673
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 980
Number of HSP's successfully gapped in prelim test: 1611
Number of HSP's that attempted gapping in prelim test: 10137
Number of HSP's gapped (non-prelim): 12233
length of query: 556
length of database: 18,247,518
effective HSP length: 107
effective length of query: 449
effective length of database: 14,195,856
effective search space: 6373939344
effective search space used: 6373939344
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.