Search of human proteins with 21389427

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21389427 GA repeat binding protein, beta 2 [Homo sapiens]
         (448 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21389427 GA repeat binding protein, beta 2 [Homo sapiens]          865   0.0  
gi|8051593 GA binding protein transcription factor, beta subunit...   498   e-141
gi|8051595 GA binding protein transcription factor, beta subunit...   482   e-136
gi|8051597 GA binding protein transcription factor, beta subunit...   440   e-123
gi|32483404 GA binding protein transcription factor, beta subuni...   423   e-118
gi|8051599 GA binding protein transcription factor, beta subunit...   423   e-118
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    96   5e-20
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    89   6e-18
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                     89   6e-18
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        88   2e-17
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         88   2e-17
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         88   2e-17
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        88   2e-17
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         88   2e-17
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         88   2e-17
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         88   2e-17
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         88   2e-17
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         84   2e-16
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled...    84   3e-16
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...    84   3e-16
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]             83   4e-16
gi|89363047 death-associated protein kinase 1 [Homo sapiens]           83   6e-16
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                     82   1e-15
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]     81   2e-15
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]     79   8e-15
gi|103471993 huntingtin interacting protein 14 [Homo sapiens]          77   2e-14
gi|239747812 PREDICTED: ankyrin repeat domain 36 [Homo sapiens]        77   3e-14
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...    77   3e-14
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    77   4e-14
gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]          75   9e-14

>gi|21389427 GA repeat binding protein, beta 2 [Homo sapiens]
          Length = 448

 Score =  865 bits (2236), Expect = 0.0
 Identities = 448/448 (100%), Positives = 448/448 (100%)

Query: 1   MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRA 60
           MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRA
Sbjct: 1   MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRA 60

Query: 61  GVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVV 120
           GVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVV
Sbjct: 61  GVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVV 120

Query: 121 ELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSM 180
           ELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSM
Sbjct: 121 ELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSM 180

Query: 181 AAPFIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSN 240
           AAPFIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSN
Sbjct: 181 AAPFIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSN 240

Query: 241 SHRATANTEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPFIV 300
           SHRATANTEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPFIV
Sbjct: 241 SHRATANTEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPFIV 300

Query: 301 TVQDGQQVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELLQQQ 360
           TVQDGQQVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELLQQQ
Sbjct: 301 TVQDGQQVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELLQQQ 360

Query: 361 LQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGE 420
           LQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGE
Sbjct: 361 LQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGE 420

Query: 421 LEERETKVTGSAGTTEPHTRVSMATVSS 448
           LEERETKVTGSAGTTEPHTRVSMATVSS
Sbjct: 421 LEERETKVTGSAGTTEPHTRVSMATVSS 448


>gi|8051593 GA binding protein transcription factor, beta subunit 1
           isoform beta 1 [Homo sapiens]
          Length = 395

 Score =  498 bits (1283), Expect = e-141
 Identities = 274/400 (68%), Positives = 311/400 (77%), Gaps = 11/400 (2%)

Query: 1   MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRA 60
           MSLVDLGK+LLEAAR GQDDEVR LMANGAPFTTDWLGTSPLHLAAQYGHYST EVLLRA
Sbjct: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60

Query: 61  GVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVV 120
           GVSRDARTKVDRTPLHMAA++GHA IVE+L+++GADVNAKDMLKMTALHWATE +H++VV
Sbjct: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120

Query: 121 ELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSM 180
           ELLIKYGADVH  SKF K+AFDI+++  N ++  ILQ AMQNQ+N NPE  + VT  +  
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT--IHA 178

Query: 181 AAP-FIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLS 239
           A P FI   G VVNL  L+SS N+   + +   S VQF NS+TSVLATLAALAEAS PLS
Sbjct: 179 ATPQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLS 238

Query: 240 NSHRA-TANTEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPF 298
           NS       TEE++   SVD +IQQV+ SGGQ+VITIVTDG+ LGN+  SIPT GIGQP 
Sbjct: 239 NSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH-SIPTSGIGQPI 297

Query: 299 IVTVQDGQQVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELLQ 358
           IVT+ DGQQVLTVPA  +AEETVI EE     P  K+  I    N V ES E  ERE LQ
Sbjct: 298 IVTMPDGQQVLTVPATDIAEETVISEE-----PPAKRQCIEIIENRV-ESAEIEEREALQ 351

Query: 359 QQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPN 398
           +QL EANR AQ+YR QLLKKEQEAE YR KLEA+ R Q N
Sbjct: 352 KQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRLQTN 391


>gi|8051595 GA binding protein transcription factor, beta subunit 1
           isoform beta 2 [Homo sapiens]
          Length = 383

 Score =  482 bits (1240), Expect = e-136
 Identities = 270/400 (67%), Positives = 305/400 (76%), Gaps = 23/400 (5%)

Query: 1   MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRA 60
           MSLVDLGK+LLEAAR GQDDEVR LMANGAPFTTDWLGTSPLHLAAQYGHYST EVLLRA
Sbjct: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60

Query: 61  GVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVV 120
           GVSRDARTKVDRTPLHMAA++GHA IVE+L+++GADVNAKDMLKMTALHWATE +H++VV
Sbjct: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120

Query: 121 ELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSM 180
           ELLIKYGADVH  SKF K+AFDI+++  N ++  ILQ AMQNQ+N NPE  + VT  +  
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT--IHA 178

Query: 181 AAP-FIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLS 239
           A P FI   G VVNL            + +   S VQF NS+TSVLATLAALAEAS PLS
Sbjct: 179 ATPQFIIGPGGVVNL------------TDETGVSAVQFGNSSTSVLATLAALAEASAPLS 226

Query: 240 NSHRA-TANTEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPF 298
           NS       TEE++   SVD +IQQV+ SGGQ+VITIVTDG+ LGN+  SIPT GIGQP 
Sbjct: 227 NSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH-SIPTSGIGQPI 285

Query: 299 IVTVQDGQQVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELLQ 358
           IVT+ DGQQVLTVPA  +AEETVI EE     P  K+  I    N V ES E  ERE LQ
Sbjct: 286 IVTMPDGQQVLTVPATDIAEETVISEE-----PPAKRQCIEIIENRV-ESAEIEEREALQ 339

Query: 359 QQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPN 398
           +QL EANR AQ+YR QLLKKEQEAE YR KLEA+ R Q N
Sbjct: 340 KQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRLQTN 379


>gi|8051597 GA binding protein transcription factor, beta subunit 1
           isoform gamma 1 [Homo sapiens]
          Length = 360

 Score =  440 bits (1131), Expect = e-123
 Identities = 243/359 (67%), Positives = 277/359 (77%), Gaps = 11/359 (3%)

Query: 1   MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRA 60
           MSLVDLGK+LLEAAR GQDDEVR LMANGAPFTTDWLGTSPLHLAAQYGHYST EVLLRA
Sbjct: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60

Query: 61  GVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVV 120
           GVSRDARTKVDRTPLHMAA++GHA IVE+L+++GADVNAKDMLKMTALHWATE +H++VV
Sbjct: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120

Query: 121 ELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSM 180
           ELLIKYGADVH  SKF K+AFDI+++  N ++  ILQ AMQNQ+N NPE  + VT  +  
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT--IHA 178

Query: 181 AAP-FIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLS 239
           A P FI   G VVNL  L+SS N+   + +   S VQF NS+TSVLATLAALAEAS PLS
Sbjct: 179 ATPQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLS 238

Query: 240 NSHRA-TANTEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPF 298
           NS       TEE++   SVD +IQQV+ SGGQ+VITIVTDG+ LGN+  SIPT GIGQP 
Sbjct: 239 NSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH-SIPTSGIGQPI 297

Query: 299 IVTVQDGQQVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELL 357
           IVT+ DGQQVLTVPA  +AEETVI EE     P  K+  I    N V ES E   R LL
Sbjct: 298 IVTMPDGQQVLTVPATDIAEETVISEE-----PPAKRQCIEIIENRV-ESAEIEVRSLL 350


>gi|32483404 GA binding protein transcription factor, beta subunit 1
           isoform gamma 2 [Homo sapiens]
          Length = 348

 Score =  423 bits (1088), Expect = e-118
 Identities = 239/359 (66%), Positives = 271/359 (75%), Gaps = 23/359 (6%)

Query: 1   MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRA 60
           MSLVDLGK+LLEAAR GQDDEVR LMANGAPFTTDWLGTSPLHLAAQYGHYST EVLLRA
Sbjct: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60

Query: 61  GVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVV 120
           GVSRDARTKVDRTPLHMAA++GHA IVE+L+++GADVNAKDMLKMTALHWATE +H++VV
Sbjct: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120

Query: 121 ELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSM 180
           ELLIKYGADVH  SKF K+AFDI+++  N ++  ILQ AMQNQ+N NPE  + VT  +  
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT--IHA 178

Query: 181 AAP-FIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLS 239
           A P FI   G VVNL            + +   S VQF NS+TSVLATLAALAEAS PLS
Sbjct: 179 ATPQFIIGPGGVVNL------------TDETGVSAVQFGNSSTSVLATLAALAEASAPLS 226

Query: 240 NSHRA-TANTEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPF 298
           NS       TEE++   SVD +IQQV+ SGGQ+VITIVTDG+ LGN+  SIPT GIGQP 
Sbjct: 227 NSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH-SIPTSGIGQPI 285

Query: 299 IVTVQDGQQVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELL 357
           IVT+ DGQQVLTVPA  +AEETVI EE     P  K+  I    N V ES E   R LL
Sbjct: 286 IVTMPDGQQVLTVPATDIAEETVISEE-----PPAKRQCIEIIENRV-ESAEIEVRSLL 338


>gi|8051599 GA binding protein transcription factor, beta subunit 1
           isoform gamma 2 [Homo sapiens]
          Length = 348

 Score =  423 bits (1088), Expect = e-118
 Identities = 239/359 (66%), Positives = 271/359 (75%), Gaps = 23/359 (6%)

Query: 1   MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRA 60
           MSLVDLGK+LLEAAR GQDDEVR LMANGAPFTTDWLGTSPLHLAAQYGHYST EVLLRA
Sbjct: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60

Query: 61  GVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVV 120
           GVSRDARTKVDRTPLHMAA++GHA IVE+L+++GADVNAKDMLKMTALHWATE +H++VV
Sbjct: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120

Query: 121 ELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSM 180
           ELLIKYGADVH  SKF K+AFDI+++  N ++  ILQ AMQNQ+N NPE  + VT  +  
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT--IHA 178

Query: 181 AAP-FIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLS 239
           A P FI   G VVNL            + +   S VQF NS+TSVLATLAALAEAS PLS
Sbjct: 179 ATPQFIIGPGGVVNL------------TDETGVSAVQFGNSSTSVLATLAALAEASAPLS 226

Query: 240 NSHRA-TANTEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPF 298
           NS       TEE++   SVD +IQQV+ SGGQ+VITIVTDG+ LGN+  SIPT GIGQP 
Sbjct: 227 NSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH-SIPTSGIGQPI 285

Query: 299 IVTVQDGQQVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELL 357
           IVT+ DGQQVLTVPA  +AEETVI EE     P  K+  I    N V ES E   R LL
Sbjct: 286 IVTMPDGQQVLTVPATDIAEETVISEE-----PPAKRQCIEIIENRV-ESAEIEVRSLL 338


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score = 96.3 bits (238), Expect = 5e-20
 Identities = 54/137 (39%), Positives = 80/137 (58%), Gaps = 2/137 (1%)

Query: 10  LLEAARKGQDDEVRTLMA--NGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDAR 67
           LLE+AR G ++++  L+   N     +D   ++PLHLAA Y      ++LL+ G    A+
Sbjct: 181 LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK 240

Query: 68  TKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYG 127
            K D  PLH A + GH  + ELLV++GA VNA D+ + T LH A  ++  +V  LL+ YG
Sbjct: 241 DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300

Query: 128 ADVHAFSKFDKSAFDIA 144
           AD    +  +KSA D+A
Sbjct: 301 ADPTLLNCHNKSAIDLA 317



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 50/139 (35%), Positives = 75/139 (53%), Gaps = 2/139 (1%)

Query: 8   KRLLEAARKGQDDEVRTLMANGAPFTTDWLG--TSPLHLAAQYGHYSTAEVLLRAGVSRD 65
           + L EA R G  + V+ L+      + D  G  ++PLH AA +G     E LL+ G +  
Sbjct: 26  RELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ 85

Query: 66  ARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIK 125
           AR      PLH A + GHA +V LL+R+GAD NA+D    T LH A  +   DV  +L++
Sbjct: 86  ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145

Query: 126 YGADVHAFSKFDKSAFDIA 144
           +GA+    +   ++A D+A
Sbjct: 146 HGAEPTIRNTDGRTALDLA 164



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 48/124 (38%), Positives = 70/124 (56%), Gaps = 2/124 (1%)

Query: 8   KRLLEAARKGQDDEVRTLMANGAPFTTDWLG--TSPLHLAAQYGHYSTAEVLLRAGVSRD 65
           ++LLEAA+ G  + V+ L    +    D  G  ++PLH AA Y   S  E LL+ G    
Sbjct: 494 RQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVH 553

Query: 66  ARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIK 125
           A+ K    PLH A + GH  + ELLV++GA VN  D+ K T LH A  +   ++ +LL++
Sbjct: 554 AKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 613

Query: 126 YGAD 129
           +GAD
Sbjct: 614 HGAD 617



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 63/216 (29%), Positives = 98/216 (45%), Gaps = 18/216 (8%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTTDWLG--TSPLHLAAQYGHYSTAEVLLRAGVSRDAR 67
           LL+AA+KG    V+ L +       D  G  ++PLHLAA Y +   AE LL+ G   +A+
Sbjct: 649 LLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQ 708

Query: 68  TKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYG 127
            K    PLH AA+ GH  +  LL++  A VNA D    T LH A ++    +  LL+ +G
Sbjct: 709 DKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 768

Query: 128 ADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDP---------- 177
           AD    ++  ++  D+    + + +L              P+  N V  P          
Sbjct: 769 ADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSG 828

Query: 178 ------VSMAAPFIFTSGEVVNLASLISSTNTKTTS 207
                 +S A+     SG    L+S++SS+ T+  S
Sbjct: 829 PSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGAS 864



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 57/169 (33%), Positives = 79/169 (46%), Gaps = 22/169 (13%)

Query: 10  LLEAARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLA------AQYGHYSTAEVLLRA-- 60
           L EAA KG+ D    L+ +GA P   +  G + L LA         G Y   E+L  A  
Sbjct: 128 LHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARS 187

Query: 61  -------------GVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTA 107
                         V+  A      TPLH+AA      IV+LL+++GADV+AKD   +  
Sbjct: 188 GNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVP 247

Query: 108 LHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVIL 156
           LH A    H +V ELL+K+GA V+A   +  +    A  KN  E+  +L
Sbjct: 248 LHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 296



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 52/158 (32%), Positives = 76/158 (48%), Gaps = 8/158 (5%)

Query: 7   GKRLLEAARKGQDDEVRT-LMANGAPFTTDWLGTSPLHLAAQYGH---YSTAEVLLRAGV 62
           G  LL+AAR+     ++  L      F       + LH AA   +       E+LLR G 
Sbjct: 332 GHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGA 391

Query: 63  SRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVEL 122
           + + +TK   TPLH+A+   H  +VE++V++ A VNA D L  T+LH A    H     L
Sbjct: 392 NINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRL 451

Query: 123 LIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAM 160
           L+ YG D +  S      F  AL+  N  +  +LQE +
Sbjct: 452 LLSYGCDPNIIS---LQGF-TALQMGNENVQQLLQEGI 485



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 82/328 (25%), Positives = 127/328 (38%), Gaps = 72/328 (21%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGV-----S 63
           L  A   G  +    L+ +GA     D    +PLH AA  G Y   ++LL+ G      +
Sbjct: 563 LHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKN 622

Query: 64  RDARTKVD-------------------------------------------------RTP 74
           RD  T +D                                                  TP
Sbjct: 623 RDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTP 682

Query: 75  LHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFS 134
           LH+AA   +  + E L+++GADVNA+D   +  LH A    H DV  LLIKY A V+A  
Sbjct: 683 LHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATD 742

Query: 135 KFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPV----TDPVS---------MA 181
           K+  +    A +K   ++  +L     +    N E   P+     D VS          A
Sbjct: 743 KWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSA 802

Query: 182 APFIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSNS 241
            P  +   +V+N      +T    +SG    S++  ++S  ++     + +E S  +S+S
Sbjct: 803 LPSCY-KPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNL---SGSFSELSSVVSSS 858

Query: 242 HRATANTEEIIEGNSVDSSIQQVMGSGG 269
               A++ E  E   VD SI Q + + G
Sbjct: 859 GTEGASSLEKKEVPGVDFSITQFVRNLG 886



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 38/111 (34%), Positives = 61/111 (54%), Gaps = 2/111 (1%)

Query: 73  TPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHA 132
           TPLH AA  G   +VE L++NGA+V A+D   +  LH A    H +VV LL+++GAD +A
Sbjct: 60  TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119

Query: 133 FSKFDKSAFDIALEKNNAEI-LVILQEAMQNQV-NVNPERANPVTDPVSMA 181
              ++ +    A  K   ++ +V+LQ   +  + N +   A  + DP + A
Sbjct: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKA 170



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 35/102 (34%), Positives = 52/102 (50%)

Query: 73  TPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHA 132
           TPLH AA      +VE L+++GADV+AKD   +  LH A    H +V ELL+K+GA V+ 
Sbjct: 528 TPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV 587

Query: 133 FSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPV 174
              +  +    A  K   EI  +L +   +    N +   P+
Sbjct: 588 ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL 629



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 33/81 (40%), Positives = 44/81 (54%), Gaps = 1/81 (1%)

Query: 22  VRTLMANGAPF-TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAA 80
           V  L+ +GA     D  G  PLH A  YGHY  AE+L++ G   +       TPLH AAA
Sbjct: 542 VEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAA 601

Query: 81  DGHAHIVELLVRNGADVNAKD 101
            G   I +LL+++GAD   K+
Sbjct: 602 KGKYEICKLLLQHGADPTKKN 622



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 44/152 (28%), Positives = 62/152 (40%), Gaps = 30/152 (19%)

Query: 13  AARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A+ K  +D V  ++ + A     D LG + LH AA  GH  T  +LL  G   +  +   
Sbjct: 407 ASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQG 466

Query: 72  RTPLHM--------------------------AAADGHAHIVELLVRNGADVNAKDM--L 103
            T L M                          AA  G    V+ L      VN +D+   
Sbjct: 467 FTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC-TVQSVNCRDIEGR 525

Query: 104 KMTALHWATERHHRDVVELLIKYGADVHAFSK 135
           + T LH+A   +   VVE L+++GADVHA  K
Sbjct: 526 QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDK 557


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score = 89.4 bits (220), Expect = 6e-18
 Identities = 52/137 (37%), Positives = 78/137 (56%), Gaps = 2/137 (1%)

Query: 10  LLEAARKGQDDEVRTLMA--NGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDAR 67
           LLEAAR G ++++  L+   N     +D   ++PLHLAA Y      ++LL+ G    A+
Sbjct: 339 LLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK 398

Query: 68  TKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYG 127
            K    PLH A + GH  + ELL+++GA VNA D+ + T LH A  ++  +V  LL+ +G
Sbjct: 399 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 458

Query: 128 ADVHAFSKFDKSAFDIA 144
           AD    +   KSA D+A
Sbjct: 459 ADPTLVNCHGKSAVDMA 475



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 53/144 (36%), Positives = 77/144 (53%), Gaps = 2/144 (1%)

Query: 5   DLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLG--TSPLHLAAQYGHYSTAEVLLRAGV 62
           D+  RLLEA++ G  + V+ L ++      D  G  ++PLH AA Y   S  E LL  G 
Sbjct: 649 DVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGA 708

Query: 63  SRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVEL 122
              A+ K    PLH A + GH  + ELLVR+GA VN  D+ K T LH A  +   ++ +L
Sbjct: 709 DVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKL 768

Query: 123 LIKYGADVHAFSKFDKSAFDIALE 146
           L+K+GAD    ++   +  D+  E
Sbjct: 769 LLKHGADPTKKNRDGNTPLDLVKE 792



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 54/139 (38%), Positives = 73/139 (52%), Gaps = 2/139 (1%)

Query: 8   KRLLEAARKGQDDEVRTLMANGAPFTTDWLG--TSPLHLAAQYGHYSTAEVLLRAGVSRD 65
           + LLEA R G    V+ L+        D  G  +SPLH AA +G     E LL+ G +  
Sbjct: 184 RELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVH 243

Query: 66  ARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIK 125
           AR      PLH A + GHA +V LL+  GAD NA+D    T LH A  +   DV  +L++
Sbjct: 244 ARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 303

Query: 126 YGADVHAFSKFDKSAFDIA 144
           +GAD +  +   KSA D+A
Sbjct: 304 HGADPNIRNTDGKSALDLA 322



 Score = 79.0 bits (193), Expect = 8e-15
 Identities = 83/264 (31%), Positives = 117/264 (44%), Gaps = 35/264 (13%)

Query: 10   LLEAARKGQDDEVRTLMANGAPFTTDWLG--TSPLHLAAQYGHYSTAEVLLRAGVSRDAR 67
            LL+AA+KG    V+ L         D  G  ++PLHLAA Y +   AE LL  G   +A+
Sbjct: 807  LLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ 866

Query: 68   TKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYG 127
             K    PLH AA+ GH  I  LL++    VNA D    T LH A ++    +  LL+ +G
Sbjct: 867  DKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 926

Query: 128  ADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFT 187
            AD    ++  ++  D+A      +I  +L +AM       PE           A P  F 
Sbjct: 927  ADPTMKNQEGQTPLDLATAD---DIRALLIDAMP------PE-----------ALPTCFK 966

Query: 188  SGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSNSHRATAN 247
                V  ASLIS  +T         S +  ++S  ++   LA LA      SN+    A 
Sbjct: 967  PQATVVSASLISPAST--------PSCLSAASSIDNLTGPLAELAVGGA--SNAGDGAAG 1016

Query: 248  TEEIIEGN--SVDSSIQQVMGSGG 269
            TE   EG    +D +I Q + S G
Sbjct: 1017 TER-KEGEVAGLDMNISQFLKSLG 1039



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 58/169 (34%), Positives = 79/169 (46%), Gaps = 22/169 (13%)

Query: 10  LLEAARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLA------AQYGHYSTAEVLLRA-- 60
           L EAA KG+ D    L+ +GA P   +  G S L LA         G Y   E+L  A  
Sbjct: 286 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARS 345

Query: 61  -------------GVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTA 107
                         V+  A      TPLH+AA      IV+LL+++GADV+AKD   +  
Sbjct: 346 GNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVP 405

Query: 108 LHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVIL 156
           LH A    H +V ELL+K+GA V+A   +  +    A  KN  E+  +L
Sbjct: 406 LHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 454



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 46/127 (36%), Positives = 64/127 (50%), Gaps = 4/127 (3%)

Query: 7   GKRLLEAARKGQDDEVR-TLMANGAPFTTDWLGTSPLHLAAQYGH---YSTAEVLLRAGV 62
           G  LL+AAR+    +V+ TL      F       + LH A    H       E+LLR G 
Sbjct: 490 GHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGA 549

Query: 63  SRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVEL 122
           + + + K   TPLH+AA   H  ++E+L ++GA +NA D L  TALH A    H     L
Sbjct: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609

Query: 123 LIKYGAD 129
           L+ YG+D
Sbjct: 610 LLSYGSD 616



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 34/102 (33%), Positives = 51/102 (50%)

Query: 73  TPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHA 132
           TPLH AA      +VE L+ +GADV+AKD   +  LH A    H +V ELL+++GA V+ 
Sbjct: 686 TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNV 745

Query: 133 FSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPV 174
              +  +    A  K   EI  +L +   +    N +   P+
Sbjct: 746 ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPL 787



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 47/156 (30%), Positives = 75/156 (48%), Gaps = 25/156 (16%)

Query: 10  LLEAARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAA----------QYGHYSTAEVLL 58
           L EAA K + +    L+++GA P   +  G S + +A           ++  +S  +   
Sbjct: 439 LHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAR 498

Query: 59  RAGVSRDART-----------KVDRTPLHMAAADGHA---HIVELLVRNGADVNAKDMLK 104
            A +++  +T           +   T LH A A  H     + ELL+R GA+VN K+   
Sbjct: 499 EADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDF 558

Query: 105 MTALHWATERHHRDVVELLIKYGADVHAFSKFDKSA 140
           MT LH A ER H DV+E+L K+GA ++A     ++A
Sbjct: 559 MTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTA 594



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 44/154 (28%), Positives = 71/154 (46%), Gaps = 12/154 (7%)

Query: 73  TPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHA 132
           +PLH AA  G   +VE L++ GA+V+A+D   +  LH A    H +VV LL+  GAD +A
Sbjct: 218 SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNA 277

Query: 133 FSKFDKSAFDIALEKNNAEILVILQE--AMQNQVNVNPERANPVTDPVSMAAPF------ 184
              ++ +    A  K   ++ ++L +  A  N  N + + A  + DP + A         
Sbjct: 278 RDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKD 337

Query: 185 ----IFTSGEVVNLASLISSTNTKTTSGDPHAST 214
                  SG    L +L++  N    + D   ST
Sbjct: 338 ELLEAARSGNEEKLMALLTPLNVNCHASDGRKST 371



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 25/74 (33%), Positives = 36/74 (48%)

Query: 40  SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNA 99
           +PLH+AA+  H    EVL + G   +A   + +T LH AA  GH     LL+  G+D + 
Sbjct: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619

Query: 100 KDMLKMTALHWATE 113
             +   TA     E
Sbjct: 620 ISLQGFTAAQMGNE 633



 Score = 30.8 bits (68), Expect = 2.6
 Identities = 40/174 (22%), Positives = 66/174 (37%), Gaps = 25/174 (14%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAG-----VS 63
           L  A   G  +    L+ +GA     D    +PLH AA         +LL  G     V+
Sbjct: 406 LHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVN 465

Query: 64  RDARTKVDRTPL----HMAAADGHAHIVELLVRNGADVNAKDMLKM------------TA 107
              ++ VD  P          +   H +    R       K  L +            TA
Sbjct: 466 CHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETA 525

Query: 108 LHWATERHH---RDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQE 158
           LH A    H   + V ELL++ GA+V+  +K   +   +A E+ + +++ +L +
Sbjct: 526 LHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHK 579


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score = 89.4 bits (220), Expect = 6e-18
 Identities = 53/151 (35%), Positives = 81/151 (53%)

Query: 6   LGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRD 65
           L +RLL AA KGQ + V  L+  GA       G +PLHLAA  GH    ++LL+AG   D
Sbjct: 10  LSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLD 69

Query: 66  ARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIK 125
            +   D+T LH A   G+  I+  L+  G  ++ +D    TALH A+        +LL+K
Sbjct: 70  VQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVK 129

Query: 126 YGADVHAFSKFDKSAFDIALEKNNAEILVIL 156
            GA+V A +K   +A  +A + ++++   +L
Sbjct: 130 AGANVLAKNKAGNTALHLACQNSHSQSTRVL 160



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 49/153 (32%), Positives = 75/153 (49%), Gaps = 1/153 (0%)

Query: 10  LLEAARKGQDDEVRTLMANGAP-FTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDART 68
           L EA+  G     + L+  GA     +  G + LHLA Q  H  +  VLL AG   D + 
Sbjct: 112 LHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKN 171

Query: 69  KVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGA 128
               T LH+AA   H  I+ LL+     V+ K+    TALH A   +H+ V ++L++ GA
Sbjct: 172 NAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGA 231

Query: 129 DVHAFSKFDKSAFDIALEKNNAEILVILQEAMQ 161
           D    +   ++  + A   NN E+ ++L +A Q
Sbjct: 232 DTTIVNNAGQTPLETARYHNNPEVALLLTKAPQ 264



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 38/137 (27%), Positives = 69/137 (50%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G + LH A+ +G   +A++L++AG +  A+ K   T LH+A  + H+    +L+  G+  
Sbjct: 108 GNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRA 167

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           + K+    T LH A   +H  ++ LL+     VH  ++   +A  +A   N+ ++  IL 
Sbjct: 168 DLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILL 227

Query: 158 EAMQNQVNVNPERANPV 174
           EA  +   VN     P+
Sbjct: 228 EAGADTTIVNNAGQTPL 244


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 53/155 (34%), Positives = 85/155 (54%), Gaps = 1/155 (0%)

Query: 5   DLGKRLLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVS 63
           D     L AAR G  D+V   +  G    T +  G + LHLAA+ GH    + LL  G S
Sbjct: 9   DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 68

Query: 64  RDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELL 123
            D+ TK   T LH+A+  G A +V++LV+ GA++NA+     T L+ A + +H DVV+ L
Sbjct: 69  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128

Query: 124 IKYGADVHAFSKFDKSAFDIALEKNNAEILVILQE 158
           ++ GA+    ++   +   +AL++ + + + IL E
Sbjct: 129 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLE 163



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 55/162 (33%), Positives = 83/162 (51%), Gaps = 3/162 (1%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G D  V  L+  GAP       G SPLH+AAQ  H    + LL+     D  T   
Sbjct: 285 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 344

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            T LH+AA  GH  + +LL+   A+ NA+ +   T LH A +++   V+ELL+KYGA + 
Sbjct: 345 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 404

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQE--AMQNQVNVNPERA 171
           A ++   +   +A    +  I+++L +  A  +  N+  E A
Sbjct: 405 AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETA 446



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 82/348 (23%), Positives = 148/348 (42%), Gaps = 19/348 (5%)

Query: 13  AARKGQDDEVRTLMAN-GAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA+ G  D  + L+    A  +    G +PLH+AA Y +   A +LL  G S  A  K  
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA      I   L+  GA+ N      +T LH A++  H D+V LL+  GA++H
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 668

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEV 191
             +K   ++  +A +++   +  IL +   +Q       A+       +     + + ++
Sbjct: 669 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQ------DAHTKLGYTPLIVACHYGNVKM 722

Query: 192 VN-LASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSNSHRATANTEE 250
           VN L    ++ N KT +G            T  +   L   A+ +   +N + A A  + 
Sbjct: 723 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 782

Query: 251 IIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPFIVTVQDGQQVLT 310
           +   + VD+   +V+        T +T+   L   +T      + +   V+ ++G   +T
Sbjct: 783 LGYISVVDT--LKVVTEEVTTTTTTITEKHKLNVPET------MTEVLDVSDEEGDDTMT 834

Query: 311 VPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELLQ 358
              G+      +KE  ++ LP     +  +  N +  S EG   + L+
Sbjct: 835 GDGGEYLRPEDLKELGDDSLP---SSQFLDGMNYLRYSLEGGRSDSLR 879



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 42/114 (36%), Positives = 67/114 (58%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+AA YG+ + A +LL  G + D   +   TPLH+A+  G+ ++V+LL+  G  +
Sbjct: 212 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 271

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAE 151
           +AK    +T LH A    H  VVELL++ GA + A +K   S   +A + ++ E
Sbjct: 272 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 325



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 48/141 (34%), Positives = 75/141 (53%), Gaps = 1/141 (0%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A+R G+ + V+ L+ + A P      G +PLH++A+ G    A VLL AG +    TK  
Sbjct: 483 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 542

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA  G   + +LL++  A  ++     +T LH A    ++ V  LL++ GA  H
Sbjct: 543 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 602

Query: 132 AFSKFDKSAFDIALEKNNAEI 152
           A +K   +   IA +KN  +I
Sbjct: 603 ATAKNGYTPLHIAAKKNQMQI 623



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 43/123 (34%), Positives = 69/123 (56%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+A +       E+L++ G S  A T+   TP+H+AA  GH +IV LL++NGA  
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           +  ++   TALH A      +VV  L++ GA V A ++ +++   IA      EI+ +L 
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 496

Query: 158 EAM 160
           + M
Sbjct: 497 QHM 499



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 44/151 (29%), Positives = 79/151 (52%), Gaps = 1/151 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           +AR+GQ D    L+  GA  +     G +PLH+AA+YG    A++LL+   + D+  K  
Sbjct: 516 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 575

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA   +  +  LL+  GA  +A      T LH A +++   +   L+ YGA+ +
Sbjct: 576 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 635

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQN 162
             +K   +   +A ++ + +++ +L +   N
Sbjct: 636 IVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 666



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 50/147 (34%), Positives = 78/147 (53%), Gaps = 5/147 (3%)

Query: 13  AARKGQDDEVRTLMANGAPF---TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           A+++G  + V+ L+  G      T D  G +PLH AA+ GH    E+LL  G    ARTK
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTK 309

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              +PLHMAA   H   V+ L+++ A V+   +  +TALH A    H  V +LL+   A+
Sbjct: 310 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 369

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVIL 156
            +A +    +   IA +KN  +++ +L
Sbjct: 370 PNARALNGFTPLHIACKKNRIKVMELL 396



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 49/164 (29%), Positives = 81/164 (49%), Gaps = 4/164 (2%)

Query: 13  AARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  G  +    L+  GA    T   G +PLH+A++ G+ +  ++LL  G   DA+T+  
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH AA  GH  +VELL+  GA + A+    ++ LH A +  H + V+ L+++ A V 
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVT 175
             +    +A  +A    +  +  +L   +  + N N    N  T
Sbjct: 339 DVTLDYLTALHVAAHCGHYRVTKLL---LDKRANPNARALNGFT 379



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 40/122 (32%), Positives = 65/122 (53%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +P+H+AA  GH +   +LL+ G S D       T LHMAA  G   +V  L+RNGA V
Sbjct: 410 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 469

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           +A+   + T LH A+     ++V+LL+++ A   A +    +   I+  +   ++  +L 
Sbjct: 470 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 529

Query: 158 EA 159
           EA
Sbjct: 530 EA 531



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 52/173 (30%), Positives = 87/173 (50%), Gaps = 5/173 (2%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  G  + V  L+ NGA P  T+  G + LH+AA+ G       LLR G   DAR + +
Sbjct: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
           +TPLH+A+  G   IV+LL+++ A  +A      T LH +      DV  +L++ GA   
Sbjct: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPF 184
             +K   +   +A +  + ++  +L   +Q +   +    N +T P+ +AA +
Sbjct: 537 LATKKGFTPLHVAAKYGSLDVAKLL---LQRRAAADSAGKNGLT-PLHVAAHY 585



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 44/147 (29%), Positives = 72/147 (48%), Gaps = 1/147 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGT-SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR GQ + VR L+ NGA          +PLH+A++ G     ++LL+     DA T   
Sbjct: 450 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 509

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH++A +G   +  +L+  GA  +       T LH A +    DV +LL++  A   
Sbjct: 510 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 569

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQE 158
           +  K   +   +A   +N ++ ++L E
Sbjct: 570 SAGKNGLTPLHVAAHYDNQKVALLLLE 596



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 35/130 (26%), Positives = 68/130 (52%)

Query: 45  AAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLK 104
           AA+ G+       L+ G+  +   +     LH+AA +GH  +V+ L+  G+ V++     
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76

Query: 105 MTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQV 164
            TALH A+     +VV++L+K GA+++A S+   +   +A ++N+ +++  L E   NQ 
Sbjct: 77  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136

Query: 165 NVNPERANPV 174
               +   P+
Sbjct: 137 TATEDGFTPL 146



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 43/157 (27%), Positives = 80/157 (50%), Gaps = 11/157 (7%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           L  A ++G +  V  L+ N    T   +    LH+AA+     +A +LL+   + D ++K
Sbjct: 146 LAVALQQGHNQAVAILLEND---TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 202

Query: 70  --VDRT------PLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVE 121
             V+RT      PLH+AA  G+ ++  LL+  GA V+      +T LH A++R + ++V+
Sbjct: 203 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 262

Query: 122 LLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQE 158
           LL+  G  + A ++   +    A    + +++ +L E
Sbjct: 263 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 299



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 37/123 (30%), Positives = 60/123 (48%), Gaps = 7/123 (5%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A+  GQ + V+ L+  GA        G +PL++AAQ  H    + LL  G ++   T+  
Sbjct: 83  ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 142

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIK--YGAD 129
            TPL +A   GH   V +L+ N    + K  +++ ALH A  +       LL++  + AD
Sbjct: 143 FTPLAVALQQGHNQAVAILLEN----DTKGKVRLPALHIAARKDDTKSAALLLQNDHNAD 198

Query: 130 VHA 132
           V +
Sbjct: 199 VQS 201


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 53/155 (34%), Positives = 85/155 (54%), Gaps = 1/155 (0%)

Query: 5   DLGKRLLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVS 63
           D     L AAR G  D+V   +  G    T +  G + LHLAA+ GH    + LL  G S
Sbjct: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89

Query: 64  RDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELL 123
            D+ TK   T LH+A+  G A +V++LV+ GA++NA+     T L+ A + +H DVV+ L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 124 IKYGADVHAFSKFDKSAFDIALEKNNAEILVILQE 158
           ++ GA+    ++   +   +AL++ + + + IL E
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLE 184



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 55/162 (33%), Positives = 83/162 (51%), Gaps = 3/162 (1%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G D  V  L+  GAP       G SPLH+AAQ  H    + LL+     D  T   
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 365

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            T LH+AA  GH  + +LL+   A+ NA+ +   T LH A +++   V+ELL+KYGA + 
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 425

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQE--AMQNQVNVNPERA 171
           A ++   +   +A    +  I+++L +  A  +  N+  E A
Sbjct: 426 AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETA 467



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 82/348 (23%), Positives = 148/348 (42%), Gaps = 19/348 (5%)

Query: 13  AARKGQDDEVRTLMAN-GAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA+ G  D  + L+    A  +    G +PLH+AA Y +   A +LL  G S  A  K  
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA      I   L+  GA+ N      +T LH A++  H D+V LL+  GA++H
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEV 191
             +K   ++  +A +++   +  IL +   +Q       A+       +     + + ++
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQ------DAHTKLGYTPLIVACHYGNVKM 743

Query: 192 VN-LASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSNSHRATANTEE 250
           VN L    ++ N KT +G            T  +   L   A+ +   +N + A A  + 
Sbjct: 744 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 803

Query: 251 IIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPFIVTVQDGQQVLT 310
           +   + VD+   +V+        T +T+   L   +T      + +   V+ ++G   +T
Sbjct: 804 LGYISVVDT--LKVVTEEVTTTTTTITEKHKLNVPET------MTEVLDVSDEEGDDTMT 855

Query: 311 VPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELLQ 358
              G+      +KE  ++ LP     +  +  N +  S EG   + L+
Sbjct: 856 GDGGEYLRPEDLKELGDDSLP---SSQFLDGMNYLRYSLEGGRSDSLR 900



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 42/114 (36%), Positives = 67/114 (58%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+AA YG+ + A +LL  G + D   +   TPLH+A+  G+ ++V+LL+  G  +
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAE 151
           +AK    +T LH A    H  VVELL++ GA + A +K   S   +A + ++ E
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 346



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 48/141 (34%), Positives = 75/141 (53%), Gaps = 1/141 (0%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A+R G+ + V+ L+ + A P      G +PLH++A+ G    A VLL AG +    TK  
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 563

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA  G   + +LL++  A  ++     +T LH A    ++ V  LL++ GA  H
Sbjct: 564 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623

Query: 132 AFSKFDKSAFDIALEKNNAEI 152
           A +K   +   IA +KN  +I
Sbjct: 624 ATAKNGYTPLHIAAKKNQMQI 644



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 43/123 (34%), Positives = 69/123 (56%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+A +       E+L++ G S  A T+   TP+H+AA  GH +IV LL++NGA  
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           +  ++   TALH A      +VV  L++ GA V A ++ +++   IA      EI+ +L 
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517

Query: 158 EAM 160
           + M
Sbjct: 518 QHM 520



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 44/151 (29%), Positives = 79/151 (52%), Gaps = 1/151 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           +AR+GQ D    L+  GA  +     G +PLH+AA+YG    A++LL+   + D+  K  
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA   +  +  LL+  GA  +A      T LH A +++   +   L+ YGA+ +
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQN 162
             +K   +   +A ++ + +++ +L +   N
Sbjct: 657 IVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 50/147 (34%), Positives = 78/147 (53%), Gaps = 5/147 (3%)

Query: 13  AARKGQDDEVRTLMANGAPF---TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           A+++G  + V+ L+  G      T D  G +PLH AA+ GH    E+LL  G    ARTK
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTK 330

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              +PLHMAA   H   V+ L+++ A V+   +  +TALH A    H  V +LL+   A+
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVIL 156
            +A +    +   IA +KN  +++ +L
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELL 417



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 49/164 (29%), Positives = 81/164 (49%), Gaps = 4/164 (2%)

Query: 13  AARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  G  +    L+  GA    T   G +PLH+A++ G+ +  ++LL  G   DA+T+  
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH AA  GH  +VELL+  GA + A+    ++ LH A +  H + V+ L+++ A V 
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVT 175
             +    +A  +A    +  +  +L   +  + N N    N  T
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLL---LDKRANPNARALNGFT 400



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 40/122 (32%), Positives = 65/122 (53%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +P+H+AA  GH +   +LL+ G S D       T LHMAA  G   +V  L+RNGA V
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           +A+   + T LH A+     ++V+LL+++ A   A +    +   I+  +   ++  +L 
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 550

Query: 158 EA 159
           EA
Sbjct: 551 EA 552



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 52/173 (30%), Positives = 87/173 (50%), Gaps = 5/173 (2%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  G  + V  L+ NGA P  T+  G + LH+AA+ G       LLR G   DAR + +
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
           +TPLH+A+  G   IV+LL+++ A  +A      T LH +      DV  +L++ GA   
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPF 184
             +K   +   +A +  + ++  +L   +Q +   +    N +T P+ +AA +
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLL---LQRRAAADSAGKNGLT-PLHVAAHY 606



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 44/147 (29%), Positives = 72/147 (48%), Gaps = 1/147 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGT-SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR GQ + VR L+ NGA          +PLH+A++ G     ++LL+     DA T   
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH++A +G   +  +L+  GA  +       T LH A +    DV +LL++  A   
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQE 158
           +  K   +   +A   +N ++ ++L E
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLE 617



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 35/130 (26%), Positives = 68/130 (52%)

Query: 45  AAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLK 104
           AA+ G+       L+ G+  +   +     LH+AA +GH  +V+ L+  G+ V++     
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 105 MTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQV 164
            TALH A+     +VV++L+K GA+++A S+   +   +A ++N+ +++  L E   NQ 
Sbjct: 98  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 165 NVNPERANPV 174
               +   P+
Sbjct: 158 TATEDGFTPL 167



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 43/157 (27%), Positives = 80/157 (50%), Gaps = 11/157 (7%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           L  A ++G +  V  L+ N    T   +    LH+AA+     +A +LL+   + D ++K
Sbjct: 167 LAVALQQGHNQAVAILLEND---TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223

Query: 70  --VDRT------PLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVE 121
             V+RT      PLH+AA  G+ ++  LL+  GA V+      +T LH A++R + ++V+
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283

Query: 122 LLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQE 158
           LL+  G  + A ++   +    A    + +++ +L E
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 37/123 (30%), Positives = 60/123 (48%), Gaps = 7/123 (5%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A+  GQ + V+ L+  GA        G +PL++AAQ  H    + LL  G ++   T+  
Sbjct: 104 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 163

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIK--YGAD 129
            TPL +A   GH   V +L+ N    + K  +++ ALH A  +       LL++  + AD
Sbjct: 164 FTPLAVALQQGHNQAVAILLEN----DTKGKVRLPALHIAARKDDTKSAALLLQNDHNAD 219

Query: 130 VHA 132
           V +
Sbjct: 220 VQS 222


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 53/155 (34%), Positives = 85/155 (54%), Gaps = 1/155 (0%)

Query: 5   DLGKRLLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVS 63
           D     L AAR G  D+V   +  G    T +  G + LHLAA+ GH    + LL  G S
Sbjct: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89

Query: 64  RDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELL 123
            D+ TK   T LH+A+  G A +V++LV+ GA++NA+     T L+ A + +H DVV+ L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 124 IKYGADVHAFSKFDKSAFDIALEKNNAEILVILQE 158
           ++ GA+    ++   +   +AL++ + + + IL E
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLE 184



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 55/162 (33%), Positives = 83/162 (51%), Gaps = 3/162 (1%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G D  V  L+  GAP       G SPLH+AAQ  H    + LL+     D  T   
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 365

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            T LH+AA  GH  + +LL+   A+ NA+ +   T LH A +++   V+ELL+KYGA + 
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 425

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQE--AMQNQVNVNPERA 171
           A ++   +   +A    +  I+++L +  A  +  N+  E A
Sbjct: 426 AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETA 467



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 82/348 (23%), Positives = 148/348 (42%), Gaps = 19/348 (5%)

Query: 13  AARKGQDDEVRTLMAN-GAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA+ G  D  + L+    A  +    G +PLH+AA Y +   A +LL  G S  A  K  
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA      I   L+  GA+ N      +T LH A++  H D+V LL+  GA++H
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEV 191
             +K   ++  +A +++   +  IL +   +Q       A+       +     + + ++
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQ------DAHTKLGYTPLIVACHYGNVKM 743

Query: 192 VN-LASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSNSHRATANTEE 250
           VN L    ++ N KT +G            T  +   L   A+ +   +N + A A  + 
Sbjct: 744 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 803

Query: 251 IIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPFIVTVQDGQQVLT 310
           +   + VD+   +V+        T +T+   L   +T      + +   V+ ++G   +T
Sbjct: 804 LGYISVVDT--LKVVTEEVTTTTTTITEKHKLNVPET------MTEVLDVSDEEGDDTMT 855

Query: 311 VPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELLQ 358
              G+      +KE  ++ LP     +  +  N +  S EG   + L+
Sbjct: 856 GDGGEYLRPEDLKELGDDSLP---SSQFLDGMNYLRYSLEGGRSDSLR 900



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 42/114 (36%), Positives = 67/114 (58%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+AA YG+ + A +LL  G + D   +   TPLH+A+  G+ ++V+LL+  G  +
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAE 151
           +AK    +T LH A    H  VVELL++ GA + A +K   S   +A + ++ E
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 346



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 48/141 (34%), Positives = 75/141 (53%), Gaps = 1/141 (0%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A+R G+ + V+ L+ + A P      G +PLH++A+ G    A VLL AG +    TK  
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 563

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA  G   + +LL++  A  ++     +T LH A    ++ V  LL++ GA  H
Sbjct: 564 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623

Query: 132 AFSKFDKSAFDIALEKNNAEI 152
           A +K   +   IA +KN  +I
Sbjct: 624 ATAKNGYTPLHIAAKKNQMQI 644



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 43/123 (34%), Positives = 69/123 (56%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+A +       E+L++ G S  A T+   TP+H+AA  GH +IV LL++NGA  
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           +  ++   TALH A      +VV  L++ GA V A ++ +++   IA      EI+ +L 
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517

Query: 158 EAM 160
           + M
Sbjct: 518 QHM 520



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 44/151 (29%), Positives = 79/151 (52%), Gaps = 1/151 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           +AR+GQ D    L+  GA  +     G +PLH+AA+YG    A++LL+   + D+  K  
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA   +  +  LL+  GA  +A      T LH A +++   +   L+ YGA+ +
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQN 162
             +K   +   +A ++ + +++ +L +   N
Sbjct: 657 IVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 50/147 (34%), Positives = 78/147 (53%), Gaps = 5/147 (3%)

Query: 13  AARKGQDDEVRTLMANGAPF---TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           A+++G  + V+ L+  G      T D  G +PLH AA+ GH    E+LL  G    ARTK
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTK 330

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              +PLHMAA   H   V+ L+++ A V+   +  +TALH A    H  V +LL+   A+
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVIL 156
            +A +    +   IA +KN  +++ +L
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELL 417



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 49/164 (29%), Positives = 81/164 (49%), Gaps = 4/164 (2%)

Query: 13  AARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  G  +    L+  GA    T   G +PLH+A++ G+ +  ++LL  G   DA+T+  
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH AA  GH  +VELL+  GA + A+    ++ LH A +  H + V+ L+++ A V 
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVT 175
             +    +A  +A    +  +  +L   +  + N N    N  T
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLL---LDKRANPNARALNGFT 400



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 40/122 (32%), Positives = 65/122 (53%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +P+H+AA  GH +   +LL+ G S D       T LHMAA  G   +V  L+RNGA V
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           +A+   + T LH A+     ++V+LL+++ A   A +    +   I+  +   ++  +L 
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 550

Query: 158 EA 159
           EA
Sbjct: 551 EA 552



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 52/173 (30%), Positives = 87/173 (50%), Gaps = 5/173 (2%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  G  + V  L+ NGA P  T+  G + LH+AA+ G       LLR G   DAR + +
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
           +TPLH+A+  G   IV+LL+++ A  +A      T LH +      DV  +L++ GA   
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPF 184
             +K   +   +A +  + ++  +L   +Q +   +    N +T P+ +AA +
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLL---LQRRAAADSAGKNGLT-PLHVAAHY 606



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 44/147 (29%), Positives = 72/147 (48%), Gaps = 1/147 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGT-SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR GQ + VR L+ NGA          +PLH+A++ G     ++LL+     DA T   
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH++A +G   +  +L+  GA  +       T LH A +    DV +LL++  A   
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQE 158
           +  K   +   +A   +N ++ ++L E
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLE 617



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 35/130 (26%), Positives = 68/130 (52%)

Query: 45  AAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLK 104
           AA+ G+       L+ G+  +   +     LH+AA +GH  +V+ L+  G+ V++     
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 105 MTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQV 164
            TALH A+     +VV++L+K GA+++A S+   +   +A ++N+ +++  L E   NQ 
Sbjct: 98  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 165 NVNPERANPV 174
               +   P+
Sbjct: 158 TATEDGFTPL 167



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 43/157 (27%), Positives = 80/157 (50%), Gaps = 11/157 (7%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           L  A ++G +  V  L+ N    T   +    LH+AA+     +A +LL+   + D ++K
Sbjct: 167 LAVALQQGHNQAVAILLEND---TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223

Query: 70  --VDRT------PLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVE 121
             V+RT      PLH+AA  G+ ++  LL+  GA V+      +T LH A++R + ++V+
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283

Query: 122 LLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQE 158
           LL+  G  + A ++   +    A    + +++ +L E
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 37/123 (30%), Positives = 60/123 (48%), Gaps = 7/123 (5%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A+  GQ + V+ L+  GA        G +PL++AAQ  H    + LL  G ++   T+  
Sbjct: 104 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 163

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIK--YGAD 129
            TPL +A   GH   V +L+ N    + K  +++ ALH A  +       LL++  + AD
Sbjct: 164 FTPLAVALQQGHNQAVAILLEN----DTKGKVRLPALHIAARKDDTKSAALLLQNDHNAD 219

Query: 130 VHA 132
           V +
Sbjct: 220 VQS 222


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 52/133 (39%), Positives = 79/133 (59%), Gaps = 1/133 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA++G  + V  L++  A     +  G +PLHL AQ GH   A+VL++ GV  DA T++ 
Sbjct: 675 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 734

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+A+  G+  +V+ L+++ ADVNAK  L  + LH A ++ H D+V LL+K GA  +
Sbjct: 735 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794

Query: 132 AFSKFDKSAFDIA 144
             S    +   IA
Sbjct: 795 EVSSDGTTPLAIA 807



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 58/171 (33%), Positives = 85/171 (49%), Gaps = 5/171 (2%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G  + V+ L+ N A P      G +PLH+AA+ GH  T   LL    S+   TK  
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA  G   + ELL+   A  NA     +T LH A   ++ D+V+LL+  G   H
Sbjct: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           + +    +   IA ++N  E   + +  +Q   + N E    VT P+ +AA
Sbjct: 630 SPAWNGYTPLHIAAKQNQVE---VARSLLQYGGSANAESVQGVT-PLHLAA 676



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 48/143 (33%), Positives = 77/143 (53%), Gaps = 3/143 (2%)

Query: 25  LMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHA 84
           L   G+P +  W G +PLH+AA+      A  LL+ G S +A +    TPLH+AA +GHA
Sbjct: 622 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 681

Query: 85  HIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIA 144
            +V LL+   A+ N  +   +T LH   +  H  V ++LIK+G  V A ++   +   +A
Sbjct: 682 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 741

Query: 145 LEKNNAEILVILQEAMQNQVNVN 167
               N +++  L   +Q+Q +VN
Sbjct: 742 SHYGNIKLVKFL---LQHQADVN 761



 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 55/200 (27%), Positives = 106/200 (53%), Gaps = 7/200 (3%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA++ Q +  R+L+  G     + + G +PLHLAAQ GH     +LL    + +   K  
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 701

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+ A +GH  + ++L+++G  V+A   +  T LH A+   +  +V+ L+++ ADV+
Sbjct: 702 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 761

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEV 191
           A +K   S    A ++ + +I+ +L   ++N  + N E ++  T P+++A    + S  V
Sbjct: 762 AKTKLGYSPLHQAAQQGHTDIVTLL---LKNGASPN-EVSSDGTTPLAIAKRLGYIS--V 815

Query: 192 VNLASLISSTNTKTTSGDPH 211
            ++  +++   +     D H
Sbjct: 816 TDVLKVVTDETSFVLVSDKH 835



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 51/156 (32%), Positives = 81/156 (51%), Gaps = 4/156 (2%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  G     + L+  GA P +    G +PLH+A +  H    E+LL+ G S DA T+  
Sbjct: 378 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 437

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+A+  GH  IV+ L++ GA  N  ++   T LH A    H +V + L++  A V+
Sbjct: 438 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 497

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVN 167
           A +K D++    A    +  ++ +L   ++N  N N
Sbjct: 498 AKAKDDQTPLHCAARIGHTNMVKLL---LENNANPN 530



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 55/171 (32%), Positives = 85/171 (49%), Gaps = 5/171 (2%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G       L+ +GAP       G SP+H+AAQ  H     +LL+     D  T   
Sbjct: 312 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 371

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA  GH  + ++L+  GA  N++ +   T LH A +++H  V+ELL+K GA + 
Sbjct: 372 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           A ++   +   +A    +   L I++  +Q   + N      V  P+ MAA
Sbjct: 432 AVTESGLTPLHVASFMGH---LPIVKNLLQRGASPNVSNVK-VETPLHMAA 478



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 47/153 (30%), Positives = 77/153 (50%), Gaps = 1/153 (0%)

Query: 5   DLGKRLLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVS 63
           D     L AAR G  D+    + NG    T +  G + LHLA++ GH      LL   + 
Sbjct: 44  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 103

Query: 64  RDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELL 123
            +  TK   T LH+AA  G   +V  LV  GA+VNA+     T L+ A + +H +VV+ L
Sbjct: 104 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163

Query: 124 IKYGADVHAFSKFDKSAFDIALEKNNAEILVIL 156
           ++ GA+ +  ++   +   +AL++ +  ++  L
Sbjct: 164 LENGANQNVATEDGFTPLAVALQQGHENVVAHL 196



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 66/219 (30%), Positives = 104/219 (47%), Gaps = 10/219 (4%)

Query: 13  AARKGQDDEVRTLMANGAPF---TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           AA+    D VR L+   A     T D L  +PLH+AA  GH+  A+VLL  G   ++R  
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 402

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+A    H  ++ELL++ GA ++A     +T LH A+   H  +V+ L++ GA 
Sbjct: 403 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 462

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSG 189
            +  +   ++   +A    + E+   L   +QN+  VN +  +  T P+  AA    T+ 
Sbjct: 463 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQT-PLHCAARIGHTN- 517

Query: 190 EVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATL 228
            V  L    ++ N  TT+G              +VLA L
Sbjct: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 556



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 35/93 (37%), Positives = 57/93 (61%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+A++ G+     +LL  G   + +TK + TPLH AA +GH  I E+L+ +GA +
Sbjct: 272 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 331

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADV 130
            AK    ++ +H A +  H D V LL++Y A++
Sbjct: 332 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 364



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 47/145 (32%), Positives = 76/145 (52%), Gaps = 1/145 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGT-SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A+R+G    VR L+  GA   T      +PLH AA+ GH   +E+LL  G    A+TK  
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 338

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            +P+HMAA   H   V LL++  A+++   +  +T LH A    H  V ++L+  GA  +
Sbjct: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 398

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
           + +    +   IA +KN+  ++ +L
Sbjct: 399 SRALNGFTPLHIACKKNHVRVMELL 423



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 43/137 (31%), Positives = 70/137 (51%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+A+  GH    + LL+ G S +       TPLHMAA  GH  + + L++N A V
Sbjct: 437 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 496

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           NAK     T LH A    H ++V+LL++  A+ +  +    +   IA  + + E ++ L 
Sbjct: 497 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 556

Query: 158 EAMQNQVNVNPERANPV 174
           E   +Q  +  +   P+
Sbjct: 557 EKEASQACMTKKGFTPL 573



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 43/143 (30%), Positives = 76/143 (53%), Gaps = 4/143 (2%)

Query: 18  QDDEVRT----LMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRT 73
           ++D+ RT    L  +  P      G +PLH+AA Y + + A++LL  G S +   +   T
Sbjct: 215 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 274

Query: 74  PLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAF 133
           PLH+A+  G+  +V LL+  GA +  K   ++T LH A    H  + E+L+ +GA + A 
Sbjct: 275 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 334

Query: 134 SKFDKSAFDIALEKNNAEILVIL 156
           +K   S   +A + ++ + + +L
Sbjct: 335 TKNGLSPIHMAAQGDHLDCVRLL 357



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 44/138 (31%), Positives = 70/138 (50%), Gaps = 1/138 (0%)

Query: 22  VRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAA 80
           V+ L+  GA P  ++    +PLH+AA+ GH   A+ LL+     +A+ K D+TPLH AA 
Sbjct: 453 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 512

Query: 81  DGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSA 140
            GH ++V+LL+ N A+ N       T LH A    H + V  L++  A     +K   + 
Sbjct: 513 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 572

Query: 141 FDIALEKNNAEILVILQE 158
             +A +     +  +L E
Sbjct: 573 LHVAAKYGKVRVAELLLE 590



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 48/153 (31%), Positives = 78/153 (50%), Gaps = 5/153 (3%)

Query: 13  AARKGQDDEVRTLM---ANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           AAR+G  + V  L+   A+ A  T    G +PLH+AA+YG    AE+LL      +A  K
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 600

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+A    +  IV+LL+  G   ++      T LH A +++  +V   L++YG  
Sbjct: 601 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 660

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQN 162
            +A S    +   +A ++ +AE++ +L     N
Sbjct: 661 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 693



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 44/145 (30%), Positives = 67/145 (46%), Gaps = 1/145 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGT-SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G  +  + L+ N A          +PLH AA+ GH +  ++LL    + +  T   
Sbjct: 477 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 536

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA +GH   V  L+   A          T LH A +     V ELL++  A  +
Sbjct: 537 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 596

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
           A  K   +   +A+  NN +I+ +L
Sbjct: 597 AAGKNGLTPLHVAVHHNNLDIVKLL 621



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 50/166 (30%), Positives = 78/166 (46%), Gaps = 13/166 (7%)

Query: 33  TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVR 92
           TT   G + LH+AA  G       L+  G + +A+++   TPL+MAA + H  +V+ L+ 
Sbjct: 106 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165

Query: 93  NGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEI 152
           NGA+ N       T L  A ++ H +VV  LI YG       K    A  IA   ++   
Sbjct: 166 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRT 221

Query: 153 LVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEVVNLASLI 198
             +L   +QN  N +       T P+ +AA +     E +N+A L+
Sbjct: 222 AAVL---LQNDPNPDVLSKTGFT-PLHIAAHY-----ENLNVAQLL 258



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 50/173 (28%), Positives = 84/173 (48%), Gaps = 7/173 (4%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           L  A ++G ++ V  L+  G   T   +    LH+AA+     TA VLL+   + D  +K
Sbjct: 181 LAVALQQGHENVVAHLINYG---TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 237

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+AA   + ++ +LL+  GA VN      +T LH A+ R +  +V LL+  GA 
Sbjct: 238 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 297

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           +   +K + +    A    +  I  IL   + +   +  +  N ++ P+ MAA
Sbjct: 298 IETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLS-PIHMAA 346



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 36/119 (30%), Positives = 58/119 (48%)

Query: 45  AAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLK 104
           AA+ G+   A   LR GV  +   +     LH+A+ +GH  +V  L+     +       
Sbjct: 52  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111

Query: 105 MTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQ 163
            TALH A      +VV  L+ YGA+V+A S+   +   +A ++N+ E++  L E   NQ
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 170


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 52/133 (39%), Positives = 79/133 (59%), Gaps = 1/133 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA++G  + V  L++  A     +  G +PLHL AQ GH   A+VL++ GV  DA T++ 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+A+  G+  +V+ L+++ ADVNAK  L  + LH A ++ H D+V LL+K GA  +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 132 AFSKFDKSAFDIA 144
             S    +   IA
Sbjct: 762 EVSSDGTTPLAIA 774



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 64/256 (25%), Positives = 124/256 (48%), Gaps = 9/256 (3%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA++ Q +  R+L+  G     + + G +PLHLAAQ GH     +LL    + +   K  
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+ A +GH  + ++L+++G  V+A   +  T LH A+   +  +V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEV 191
           A +K   S    A ++ + +I+ +L   ++N  + N E ++  T P+++A    + S  V
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLL---LKNGASPN-EVSSDGTTPLAIAKRLGYIS--V 782

Query: 192 VNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSNSHRATANTEEI 251
            ++  +++   +     D H   + F  +   +L       E  +      R + + +E 
Sbjct: 783 TDVLKVVTDETSFVLVSDKH--RMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840

Query: 252 IEGNSVDSSIQQVMGS 267
            E       + QV+ S
Sbjct: 841 KELLDFVPKLDQVVES 856



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 58/171 (33%), Positives = 85/171 (49%), Gaps = 5/171 (2%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G  + V+ L+ N A P      G +PLH+AA+ GH  T   LL    S+   TK  
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA  G   + ELL+   A  NA     +T LH A   ++ D+V+LL+  G   H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           + +    +   IA ++N  E   + +  +Q   + N E    VT P+ +AA
Sbjct: 597 SPAWNGYTPLHIAAKQNQVE---VARSLLQYGGSANAESVQGVT-PLHLAA 643



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 48/143 (33%), Positives = 77/143 (53%), Gaps = 3/143 (2%)

Query: 25  LMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHA 84
           L   G+P +  W G +PLH+AA+      A  LL+ G S +A +    TPLH+AA +GHA
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648

Query: 85  HIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIA 144
            +V LL+   A+ N  +   +T LH   +  H  V ++LIK+G  V A ++   +   +A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708

Query: 145 LEKNNAEILVILQEAMQNQVNVN 167
               N +++  L   +Q+Q +VN
Sbjct: 709 SHYGNIKLVKFL---LQHQADVN 728



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 51/156 (32%), Positives = 81/156 (51%), Gaps = 4/156 (2%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  G     + L+  GA P +    G +PLH+A +  H    E+LL+ G S DA T+  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+A+  GH  IV+ L++ GA  N  ++   T LH A    H +V + L++  A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVN 167
           A +K D++    A    +  ++ +L   ++N  N N
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNANPN 497



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 55/171 (32%), Positives = 85/171 (49%), Gaps = 5/171 (2%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G       L+ +GAP       G SP+H+AAQ  H     +LL+     D  T   
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA  GH  + ++L+  GA  N++ +   T LH A +++H  V+ELL+K GA + 
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           A ++   +   +A    +   L I++  +Q   + N      V  P+ MAA
Sbjct: 399 AVTESGLTPLHVASFMGH---LPIVKNLLQRGASPNVSNVK-VETPLHMAA 445



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 47/153 (30%), Positives = 77/153 (50%), Gaps = 1/153 (0%)

Query: 5   DLGKRLLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVS 63
           D     L AAR G  D+    + NG    T +  G + LHLA++ GH      LL   + 
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70

Query: 64  RDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELL 123
            +  TK   T LH+AA  G   +V  LV  GA+VNA+     T L+ A + +H +VV+ L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 124 IKYGADVHAFSKFDKSAFDIALEKNNAEILVIL 156
           ++ GA+ +  ++   +   +AL++ +  ++  L
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHL 163



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 66/219 (30%), Positives = 104/219 (47%), Gaps = 10/219 (4%)

Query: 13  AARKGQDDEVRTLMANGAPF---TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           AA+    D VR L+   A     T D L  +PLH+AA  GH+  A+VLL  G   ++R  
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+A    H  ++ELL++ GA ++A     +T LH A+   H  +V+ L++ GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSG 189
            +  +   ++   +A    + E+   L   +QN+  VN +  +  T P+  AA    T+ 
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQT-PLHCAARIGHTN- 484

Query: 190 EVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATL 228
            V  L    ++ N  TT+G              +VLA L
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 35/93 (37%), Positives = 57/93 (61%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+A++ G+     +LL  G   + +TK + TPLH AA +GH  I E+L+ +GA +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADV 130
            AK    ++ +H A +  H D V LL++Y A++
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 47/145 (32%), Positives = 76/145 (52%), Gaps = 1/145 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGT-SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A+R+G    VR L+  GA   T      +PLH AA+ GH   +E+LL  G    A+TK  
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            +P+HMAA   H   V LL++  A+++   +  +T LH A    H  V ++L+  GA  +
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
           + +    +   IA +KN+  ++ +L
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELL 390



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 43/137 (31%), Positives = 70/137 (51%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+A+  GH    + LL+ G S +       TPLHMAA  GH  + + L++N A V
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           NAK     T LH A    H ++V+LL++  A+ +  +    +   IA  + + E ++ L 
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523

Query: 158 EAMQNQVNVNPERANPV 174
           E   +Q  +  +   P+
Sbjct: 524 EKEASQACMTKKGFTPL 540



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 43/143 (30%), Positives = 76/143 (53%), Gaps = 4/143 (2%)

Query: 18  QDDEVRT----LMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRT 73
           ++D+ RT    L  +  P      G +PLH+AA Y + + A++LL  G S +   +   T
Sbjct: 182 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241

Query: 74  PLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAF 133
           PLH+A+  G+  +V LL+  GA +  K   ++T LH A    H  + E+L+ +GA + A 
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301

Query: 134 SKFDKSAFDIALEKNNAEILVIL 156
           +K   S   +A + ++ + + +L
Sbjct: 302 TKNGLSPIHMAAQGDHLDCVRLL 324



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 44/138 (31%), Positives = 70/138 (50%), Gaps = 1/138 (0%)

Query: 22  VRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAA 80
           V+ L+  GA P  ++    +PLH+AA+ GH   A+ LL+     +A+ K D+TPLH AA 
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 81  DGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSA 140
            GH ++V+LL+ N A+ N       T LH A    H + V  L++  A     +K   + 
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 141 FDIALEKNNAEILVILQE 158
             +A +     +  +L E
Sbjct: 540 LHVAAKYGKVRVAELLLE 557



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 48/153 (31%), Positives = 78/153 (50%), Gaps = 5/153 (3%)

Query: 13  AARKGQDDEVRTLM---ANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           AAR+G  + V  L+   A+ A  T    G +PLH+AA+YG    AE+LL      +A  K
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+A    +  IV+LL+  G   ++      T LH A +++  +V   L++YG  
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQN 162
            +A S    +   +A ++ +AE++ +L     N
Sbjct: 628 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 44/145 (30%), Positives = 67/145 (46%), Gaps = 1/145 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGT-SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G  +  + L+ N A          +PLH AA+ GH +  ++LL    + +  T   
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA +GH   V  L+   A          T LH A +     V ELL++  A  +
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
           A  K   +   +A+  NN +I+ +L
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLL 588



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 50/166 (30%), Positives = 78/166 (46%), Gaps = 13/166 (7%)

Query: 33  TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVR 92
           TT   G + LH+AA  G       L+  G + +A+++   TPL+MAA + H  +V+ L+ 
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 93  NGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEI 152
           NGA+ N       T L  A ++ H +VV  LI YG       K    A  IA   ++   
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRT 188

Query: 153 LVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEVVNLASLI 198
             +L   +QN  N +       T P+ +AA +     E +N+A L+
Sbjct: 189 AAVL---LQNDPNPDVLSKTGFT-PLHIAAHY-----ENLNVAQLL 225



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 50/173 (28%), Positives = 84/173 (48%), Gaps = 7/173 (4%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           L  A ++G ++ V  L+  G   T   +    LH+AA+     TA VLL+   + D  +K
Sbjct: 148 LAVALQQGHENVVAHLINYG---TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+AA   + ++ +LL+  GA VN      +T LH A+ R +  +V LL+  GA 
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           +   +K + +    A    +  I  IL   + +   +  +  N ++ P+ MAA
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLS-PIHMAA 313



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 36/119 (30%), Positives = 58/119 (48%)

Query: 45  AAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLK 104
           AA+ G+   A   LR GV  +   +     LH+A+ +GH  +V  L+     +       
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 105 MTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQ 163
            TALH A      +VV  L+ YGA+V+A S+   +   +A ++N+ E++  L E   NQ
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 52/133 (39%), Positives = 79/133 (59%), Gaps = 1/133 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA++G  + V  L++  A     +  G +PLHL AQ GH   A+VL++ GV  DA T++ 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+A+  G+  +V+ L+++ ADVNAK  L  + LH A ++ H D+V LL+K GA  +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 132 AFSKFDKSAFDIA 144
             S    +   IA
Sbjct: 762 EVSSDGTTPLAIA 774



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 64/256 (25%), Positives = 124/256 (48%), Gaps = 9/256 (3%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA++ Q +  R+L+  G     + + G +PLHLAAQ GH     +LL    + +   K  
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+ A +GH  + ++L+++G  V+A   +  T LH A+   +  +V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEV 191
           A +K   S    A ++ + +I+ +L   ++N  + N E ++  T P+++A    + S  V
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLL---LKNGASPN-EVSSDGTTPLAIAKRLGYIS--V 782

Query: 192 VNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSNSHRATANTEEI 251
            ++  +++   +     D H   + F  +   +L       E  +      R + + +E 
Sbjct: 783 TDVLKVVTDETSFVLVSDKH--RMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840

Query: 252 IEGNSVDSSIQQVMGS 267
            E       + QV+ S
Sbjct: 841 KELLDFVPKLDQVVES 856



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 58/171 (33%), Positives = 85/171 (49%), Gaps = 5/171 (2%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G  + V+ L+ N A P      G +PLH+AA+ GH  T   LL    S+   TK  
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA  G   + ELL+   A  NA     +T LH A   ++ D+V+LL+  G   H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           + +    +   IA ++N  E   + +  +Q   + N E    VT P+ +AA
Sbjct: 597 SPAWNGYTPLHIAAKQNQVE---VARSLLQYGGSANAESVQGVT-PLHLAA 643



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 48/143 (33%), Positives = 77/143 (53%), Gaps = 3/143 (2%)

Query: 25  LMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHA 84
           L   G+P +  W G +PLH+AA+      A  LL+ G S +A +    TPLH+AA +GHA
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648

Query: 85  HIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIA 144
            +V LL+   A+ N  +   +T LH   +  H  V ++LIK+G  V A ++   +   +A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708

Query: 145 LEKNNAEILVILQEAMQNQVNVN 167
               N +++  L   +Q+Q +VN
Sbjct: 709 SHYGNIKLVKFL---LQHQADVN 728



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 51/156 (32%), Positives = 81/156 (51%), Gaps = 4/156 (2%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  G     + L+  GA P +    G +PLH+A +  H    E+LL+ G S DA T+  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+A+  GH  IV+ L++ GA  N  ++   T LH A    H +V + L++  A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVN 167
           A +K D++    A    +  ++ +L   ++N  N N
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNANPN 497



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 55/171 (32%), Positives = 85/171 (49%), Gaps = 5/171 (2%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G       L+ +GAP       G SP+H+AAQ  H     +LL+     D  T   
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA  GH  + ++L+  GA  N++ +   T LH A +++H  V+ELL+K GA + 
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           A ++   +   +A    +   L I++  +Q   + N      V  P+ MAA
Sbjct: 399 AVTESGLTPLHVASFMGH---LPIVKNLLQRGASPNVSNVK-VETPLHMAA 445



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 47/153 (30%), Positives = 77/153 (50%), Gaps = 1/153 (0%)

Query: 5   DLGKRLLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVS 63
           D     L AAR G  D+    + NG    T +  G + LHLA++ GH      LL   + 
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70

Query: 64  RDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELL 123
            +  TK   T LH+AA  G   +V  LV  GA+VNA+     T L+ A + +H +VV+ L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 124 IKYGADVHAFSKFDKSAFDIALEKNNAEILVIL 156
           ++ GA+ +  ++   +   +AL++ +  ++  L
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHL 163



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 66/219 (30%), Positives = 104/219 (47%), Gaps = 10/219 (4%)

Query: 13  AARKGQDDEVRTLMANGAPF---TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           AA+    D VR L+   A     T D L  +PLH+AA  GH+  A+VLL  G   ++R  
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+A    H  ++ELL++ GA ++A     +T LH A+   H  +V+ L++ GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSG 189
            +  +   ++   +A    + E+   L   +QN+  VN +  +  T P+  AA    T+ 
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQT-PLHCAARIGHTN- 484

Query: 190 EVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATL 228
            V  L    ++ N  TT+G              +VLA L
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 35/93 (37%), Positives = 57/93 (61%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+A++ G+     +LL  G   + +TK + TPLH AA +GH  I E+L+ +GA +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADV 130
            AK    ++ +H A +  H D V LL++Y A++
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 47/145 (32%), Positives = 76/145 (52%), Gaps = 1/145 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGT-SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A+R+G    VR L+  GA   T      +PLH AA+ GH   +E+LL  G    A+TK  
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            +P+HMAA   H   V LL++  A+++   +  +T LH A    H  V ++L+  GA  +
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
           + +    +   IA +KN+  ++ +L
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELL 390



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 43/137 (31%), Positives = 70/137 (51%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+A+  GH    + LL+ G S +       TPLHMAA  GH  + + L++N A V
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           NAK     T LH A    H ++V+LL++  A+ +  +    +   IA  + + E ++ L 
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523

Query: 158 EAMQNQVNVNPERANPV 174
           E   +Q  +  +   P+
Sbjct: 524 EKEASQACMTKKGFTPL 540



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 43/143 (30%), Positives = 76/143 (53%), Gaps = 4/143 (2%)

Query: 18  QDDEVRT----LMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRT 73
           ++D+ RT    L  +  P      G +PLH+AA Y + + A++LL  G S +   +   T
Sbjct: 182 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241

Query: 74  PLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAF 133
           PLH+A+  G+  +V LL+  GA +  K   ++T LH A    H  + E+L+ +GA + A 
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301

Query: 134 SKFDKSAFDIALEKNNAEILVIL 156
           +K   S   +A + ++ + + +L
Sbjct: 302 TKNGLSPIHMAAQGDHLDCVRLL 324



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 44/138 (31%), Positives = 70/138 (50%), Gaps = 1/138 (0%)

Query: 22  VRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAA 80
           V+ L+  GA P  ++    +PLH+AA+ GH   A+ LL+     +A+ K D+TPLH AA 
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 81  DGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSA 140
            GH ++V+LL+ N A+ N       T LH A    H + V  L++  A     +K   + 
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 141 FDIALEKNNAEILVILQE 158
             +A +     +  +L E
Sbjct: 540 LHVAAKYGKVRVAELLLE 557



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 48/153 (31%), Positives = 78/153 (50%), Gaps = 5/153 (3%)

Query: 13  AARKGQDDEVRTLM---ANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           AAR+G  + V  L+   A+ A  T    G +PLH+AA+YG    AE+LL      +A  K
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+A    +  IV+LL+  G   ++      T LH A +++  +V   L++YG  
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQN 162
            +A S    +   +A ++ +AE++ +L     N
Sbjct: 628 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 44/145 (30%), Positives = 67/145 (46%), Gaps = 1/145 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGT-SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G  +  + L+ N A          +PLH AA+ GH +  ++LL    + +  T   
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA +GH   V  L+   A          T LH A +     V ELL++  A  +
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
           A  K   +   +A+  NN +I+ +L
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLL 588



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 50/166 (30%), Positives = 78/166 (46%), Gaps = 13/166 (7%)

Query: 33  TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVR 92
           TT   G + LH+AA  G       L+  G + +A+++   TPL+MAA + H  +V+ L+ 
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 93  NGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEI 152
           NGA+ N       T L  A ++ H +VV  LI YG       K    A  IA   ++   
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRT 188

Query: 153 LVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEVVNLASLI 198
             +L   +QN  N +       T P+ +AA +     E +N+A L+
Sbjct: 189 AAVL---LQNDPNPDVLSKTGFT-PLHIAAHY-----ENLNVAQLL 225



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 50/173 (28%), Positives = 84/173 (48%), Gaps = 7/173 (4%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           L  A ++G ++ V  L+  G   T   +    LH+AA+     TA VLL+   + D  +K
Sbjct: 148 LAVALQQGHENVVAHLINYG---TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+AA   + ++ +LL+  GA VN      +T LH A+ R +  +V LL+  GA 
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           +   +K + +    A    +  I  IL   + +   +  +  N ++ P+ MAA
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLS-PIHMAA 313



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 36/119 (30%), Positives = 58/119 (48%)

Query: 45  AAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLK 104
           AA+ G+   A   LR GV  +   +     LH+A+ +GH  +V  L+     +       
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 105 MTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQ 163
            TALH A      +VV  L+ YGA+V+A S+   +   +A ++N+ E++  L E   NQ
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 52/133 (39%), Positives = 79/133 (59%), Gaps = 1/133 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA++G  + V  L++  A     +  G +PLHL AQ GH   A+VL++ GV  DA T++ 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+A+  G+  +V+ L+++ ADVNAK  L  + LH A ++ H D+V LL+K GA  +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 132 AFSKFDKSAFDIA 144
             S    +   IA
Sbjct: 762 EVSSDGTTPLAIA 774



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 64/256 (25%), Positives = 124/256 (48%), Gaps = 9/256 (3%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA++ Q +  R+L+  G     + + G +PLHLAAQ GH     +LL    + +   K  
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+ A +GH  + ++L+++G  V+A   +  T LH A+   +  +V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEV 191
           A +K   S    A ++ + +I+ +L   ++N  + N E ++  T P+++A    + S  V
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLL---LKNGASPN-EVSSDGTTPLAIAKRLGYIS--V 782

Query: 192 VNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSNSHRATANTEEI 251
            ++  +++   +     D H   + F  +   +L       E  +      R + + +E 
Sbjct: 783 TDVLKVVTDETSFVLVSDKH--RMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840

Query: 252 IEGNSVDSSIQQVMGS 267
            E       + QV+ S
Sbjct: 841 KELLDFVPKLDQVVES 856



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 58/171 (33%), Positives = 85/171 (49%), Gaps = 5/171 (2%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G  + V+ L+ N A P      G +PLH+AA+ GH  T   LL    S+   TK  
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA  G   + ELL+   A  NA     +T LH A   ++ D+V+LL+  G   H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           + +    +   IA ++N  E   + +  +Q   + N E    VT P+ +AA
Sbjct: 597 SPAWNGYTPLHIAAKQNQVE---VARSLLQYGGSANAESVQGVT-PLHLAA 643



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 48/143 (33%), Positives = 77/143 (53%), Gaps = 3/143 (2%)

Query: 25  LMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHA 84
           L   G+P +  W G +PLH+AA+      A  LL+ G S +A +    TPLH+AA +GHA
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648

Query: 85  HIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIA 144
            +V LL+   A+ N  +   +T LH   +  H  V ++LIK+G  V A ++   +   +A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708

Query: 145 LEKNNAEILVILQEAMQNQVNVN 167
               N +++  L   +Q+Q +VN
Sbjct: 709 SHYGNIKLVKFL---LQHQADVN 728



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 51/156 (32%), Positives = 81/156 (51%), Gaps = 4/156 (2%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  G     + L+  GA P +    G +PLH+A +  H    E+LL+ G S DA T+  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+A+  GH  IV+ L++ GA  N  ++   T LH A    H +V + L++  A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVN 167
           A +K D++    A    +  ++ +L   ++N  N N
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNANPN 497



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 55/171 (32%), Positives = 85/171 (49%), Gaps = 5/171 (2%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G       L+ +GAP       G SP+H+AAQ  H     +LL+     D  T   
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA  GH  + ++L+  GA  N++ +   T LH A +++H  V+ELL+K GA + 
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           A ++   +   +A    +   L I++  +Q   + N      V  P+ MAA
Sbjct: 399 AVTESGLTPLHVASFMGH---LPIVKNLLQRGASPNVSNVK-VETPLHMAA 445



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 47/153 (30%), Positives = 77/153 (50%), Gaps = 1/153 (0%)

Query: 5   DLGKRLLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVS 63
           D     L AAR G  D+    + NG    T +  G + LHLA++ GH      LL   + 
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70

Query: 64  RDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELL 123
            +  TK   T LH+AA  G   +V  LV  GA+VNA+     T L+ A + +H +VV+ L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 124 IKYGADVHAFSKFDKSAFDIALEKNNAEILVIL 156
           ++ GA+ +  ++   +   +AL++ +  ++  L
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHL 163



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 66/219 (30%), Positives = 104/219 (47%), Gaps = 10/219 (4%)

Query: 13  AARKGQDDEVRTLMANGAPF---TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           AA+    D VR L+   A     T D L  +PLH+AA  GH+  A+VLL  G   ++R  
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+A    H  ++ELL++ GA ++A     +T LH A+   H  +V+ L++ GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSG 189
            +  +   ++   +A    + E+   L   +QN+  VN +  +  T P+  AA    T+ 
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQT-PLHCAARIGHTN- 484

Query: 190 EVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATL 228
            V  L    ++ N  TT+G              +VLA L
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 35/93 (37%), Positives = 57/93 (61%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+A++ G+     +LL  G   + +TK + TPLH AA +GH  I E+L+ +GA +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADV 130
            AK    ++ +H A +  H D V LL++Y A++
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 47/145 (32%), Positives = 76/145 (52%), Gaps = 1/145 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGT-SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A+R+G    VR L+  GA   T      +PLH AA+ GH   +E+LL  G    A+TK  
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            +P+HMAA   H   V LL++  A+++   +  +T LH A    H  V ++L+  GA  +
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
           + +    +   IA +KN+  ++ +L
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELL 390



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 43/137 (31%), Positives = 70/137 (51%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+A+  GH    + LL+ G S +       TPLHMAA  GH  + + L++N A V
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           NAK     T LH A    H ++V+LL++  A+ +  +    +   IA  + + E ++ L 
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523

Query: 158 EAMQNQVNVNPERANPV 174
           E   +Q  +  +   P+
Sbjct: 524 EKEASQACMTKKGFTPL 540



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 43/143 (30%), Positives = 76/143 (53%), Gaps = 4/143 (2%)

Query: 18  QDDEVRT----LMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRT 73
           ++D+ RT    L  +  P      G +PLH+AA Y + + A++LL  G S +   +   T
Sbjct: 182 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241

Query: 74  PLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAF 133
           PLH+A+  G+  +V LL+  GA +  K   ++T LH A    H  + E+L+ +GA + A 
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301

Query: 134 SKFDKSAFDIALEKNNAEILVIL 156
           +K   S   +A + ++ + + +L
Sbjct: 302 TKNGLSPIHMAAQGDHLDCVRLL 324



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 44/138 (31%), Positives = 70/138 (50%), Gaps = 1/138 (0%)

Query: 22  VRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAA 80
           V+ L+  GA P  ++    +PLH+AA+ GH   A+ LL+     +A+ K D+TPLH AA 
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 81  DGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSA 140
            GH ++V+LL+ N A+ N       T LH A    H + V  L++  A     +K   + 
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 141 FDIALEKNNAEILVILQE 158
             +A +     +  +L E
Sbjct: 540 LHVAAKYGKVRVAELLLE 557



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 48/153 (31%), Positives = 78/153 (50%), Gaps = 5/153 (3%)

Query: 13  AARKGQDDEVRTLM---ANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           AAR+G  + V  L+   A+ A  T    G +PLH+AA+YG    AE+LL      +A  K
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+A    +  IV+LL+  G   ++      T LH A +++  +V   L++YG  
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQN 162
            +A S    +   +A ++ +AE++ +L     N
Sbjct: 628 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 44/145 (30%), Positives = 67/145 (46%), Gaps = 1/145 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGT-SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G  +  + L+ N A          +PLH AA+ GH +  ++LL    + +  T   
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA +GH   V  L+   A          T LH A +     V ELL++  A  +
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
           A  K   +   +A+  NN +I+ +L
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLL 588



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 50/166 (30%), Positives = 78/166 (46%), Gaps = 13/166 (7%)

Query: 33  TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVR 92
           TT   G + LH+AA  G       L+  G + +A+++   TPL+MAA + H  +V+ L+ 
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 93  NGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEI 152
           NGA+ N       T L  A ++ H +VV  LI YG       K    A  IA   ++   
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRT 188

Query: 153 LVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEVVNLASLI 198
             +L   +QN  N +       T P+ +AA +     E +N+A L+
Sbjct: 189 AAVL---LQNDPNPDVLSKTGFT-PLHIAAHY-----ENLNVAQLL 225



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 50/173 (28%), Positives = 84/173 (48%), Gaps = 7/173 (4%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           L  A ++G ++ V  L+  G   T   +    LH+AA+     TA VLL+   + D  +K
Sbjct: 148 LAVALQQGHENVVAHLINYG---TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+AA   + ++ +LL+  GA VN      +T LH A+ R +  +V LL+  GA 
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           +   +K + +    A    +  I  IL   + +   +  +  N ++ P+ MAA
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLS-PIHMAA 313



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 36/119 (30%), Positives = 58/119 (48%)

Query: 45  AAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLK 104
           AA+ G+   A   LR GV  +   +     LH+A+ +GH  +V  L+     +       
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 105 MTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQ 163
            TALH A      +VV  L+ YGA+V+A S+   +   +A ++N+ E++  L E   NQ
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 52/133 (39%), Positives = 79/133 (59%), Gaps = 1/133 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA++G  + V  L++  A     +  G +PLHL AQ GH   A+VL++ GV  DA T++ 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+A+  G+  +V+ L+++ ADVNAK  L  + LH A ++ H D+V LL+K GA  +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 132 AFSKFDKSAFDIA 144
             S    +   IA
Sbjct: 762 EVSSDGTTPLAIA 774



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 64/256 (25%), Positives = 124/256 (48%), Gaps = 9/256 (3%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA++ Q +  R+L+  G     + + G +PLHLAAQ GH     +LL    + +   K  
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+ A +GH  + ++L+++G  V+A   +  T LH A+   +  +V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEV 191
           A +K   S    A ++ + +I+ +L   ++N  + N E ++  T P+++A    + S  V
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLL---LKNGASPN-EVSSDGTTPLAIAKRLGYIS--V 782

Query: 192 VNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSNSHRATANTEEI 251
            ++  +++   +     D H   + F  +   +L       E  +      R + + +E 
Sbjct: 783 TDVLKVVTDETSFVLVSDKH--RMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840

Query: 252 IEGNSVDSSIQQVMGS 267
            E       + QV+ S
Sbjct: 841 KELLDFVPKLDQVVES 856



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 58/171 (33%), Positives = 85/171 (49%), Gaps = 5/171 (2%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G  + V+ L+ N A P      G +PLH+AA+ GH  T   LL    S+   TK  
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA  G   + ELL+   A  NA     +T LH A   ++ D+V+LL+  G   H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           + +    +   IA ++N  E   + +  +Q   + N E    VT P+ +AA
Sbjct: 597 SPAWNGYTPLHIAAKQNQVE---VARSLLQYGGSANAESVQGVT-PLHLAA 643



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 48/143 (33%), Positives = 77/143 (53%), Gaps = 3/143 (2%)

Query: 25  LMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHA 84
           L   G+P +  W G +PLH+AA+      A  LL+ G S +A +    TPLH+AA +GHA
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648

Query: 85  HIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIA 144
            +V LL+   A+ N  +   +T LH   +  H  V ++LIK+G  V A ++   +   +A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708

Query: 145 LEKNNAEILVILQEAMQNQVNVN 167
               N +++  L   +Q+Q +VN
Sbjct: 709 SHYGNIKLVKFL---LQHQADVN 728



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 51/156 (32%), Positives = 81/156 (51%), Gaps = 4/156 (2%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  G     + L+  GA P +    G +PLH+A +  H    E+LL+ G S DA T+  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+A+  GH  IV+ L++ GA  N  ++   T LH A    H +V + L++  A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVN 167
           A +K D++    A    +  ++ +L   ++N  N N
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNANPN 497



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 55/171 (32%), Positives = 85/171 (49%), Gaps = 5/171 (2%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G       L+ +GAP       G SP+H+AAQ  H     +LL+     D  T   
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA  GH  + ++L+  GA  N++ +   T LH A +++H  V+ELL+K GA + 
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           A ++   +   +A    +   L I++  +Q   + N      V  P+ MAA
Sbjct: 399 AVTESGLTPLHVASFMGH---LPIVKNLLQRGASPNVSNVK-VETPLHMAA 445



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 47/153 (30%), Positives = 77/153 (50%), Gaps = 1/153 (0%)

Query: 5   DLGKRLLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVS 63
           D     L AAR G  D+    + NG    T +  G + LHLA++ GH      LL   + 
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70

Query: 64  RDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELL 123
            +  TK   T LH+AA  G   +V  LV  GA+VNA+     T L+ A + +H +VV+ L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 124 IKYGADVHAFSKFDKSAFDIALEKNNAEILVIL 156
           ++ GA+ +  ++   +   +AL++ +  ++  L
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHL 163



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 66/219 (30%), Positives = 104/219 (47%), Gaps = 10/219 (4%)

Query: 13  AARKGQDDEVRTLMANGAPF---TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           AA+    D VR L+   A     T D L  +PLH+AA  GH+  A+VLL  G   ++R  
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+A    H  ++ELL++ GA ++A     +T LH A+   H  +V+ L++ GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSG 189
            +  +   ++   +A    + E+   L   +QN+  VN +  +  T P+  AA    T+ 
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQT-PLHCAARIGHTN- 484

Query: 190 EVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATL 228
            V  L    ++ N  TT+G              +VLA L
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 35/93 (37%), Positives = 57/93 (61%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+A++ G+     +LL  G   + +TK + TPLH AA +GH  I E+L+ +GA +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADV 130
            AK    ++ +H A +  H D V LL++Y A++
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 47/145 (32%), Positives = 76/145 (52%), Gaps = 1/145 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGT-SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A+R+G    VR L+  GA   T      +PLH AA+ GH   +E+LL  G    A+TK  
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            +P+HMAA   H   V LL++  A+++   +  +T LH A    H  V ++L+  GA  +
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
           + +    +   IA +KN+  ++ +L
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELL 390



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 43/137 (31%), Positives = 70/137 (51%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+A+  GH    + LL+ G S +       TPLHMAA  GH  + + L++N A V
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           NAK     T LH A    H ++V+LL++  A+ +  +    +   IA  + + E ++ L 
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523

Query: 158 EAMQNQVNVNPERANPV 174
           E   +Q  +  +   P+
Sbjct: 524 EKEASQACMTKKGFTPL 540



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 43/143 (30%), Positives = 76/143 (53%), Gaps = 4/143 (2%)

Query: 18  QDDEVRT----LMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRT 73
           ++D+ RT    L  +  P      G +PLH+AA Y + + A++LL  G S +   +   T
Sbjct: 182 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241

Query: 74  PLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAF 133
           PLH+A+  G+  +V LL+  GA +  K   ++T LH A    H  + E+L+ +GA + A 
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301

Query: 134 SKFDKSAFDIALEKNNAEILVIL 156
           +K   S   +A + ++ + + +L
Sbjct: 302 TKNGLSPIHMAAQGDHLDCVRLL 324



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 44/138 (31%), Positives = 70/138 (50%), Gaps = 1/138 (0%)

Query: 22  VRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAA 80
           V+ L+  GA P  ++    +PLH+AA+ GH   A+ LL+     +A+ K D+TPLH AA 
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 81  DGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSA 140
            GH ++V+LL+ N A+ N       T LH A    H + V  L++  A     +K   + 
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 141 FDIALEKNNAEILVILQE 158
             +A +     +  +L E
Sbjct: 540 LHVAAKYGKVRVAELLLE 557



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 48/153 (31%), Positives = 78/153 (50%), Gaps = 5/153 (3%)

Query: 13  AARKGQDDEVRTLM---ANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           AAR+G  + V  L+   A+ A  T    G +PLH+AA+YG    AE+LL      +A  K
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+A    +  IV+LL+  G   ++      T LH A +++  +V   L++YG  
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQN 162
            +A S    +   +A ++ +AE++ +L     N
Sbjct: 628 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 44/145 (30%), Positives = 67/145 (46%), Gaps = 1/145 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGT-SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G  +  + L+ N A          +PLH AA+ GH +  ++LL    + +  T   
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA +GH   V  L+   A          T LH A +     V ELL++  A  +
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
           A  K   +   +A+  NN +I+ +L
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLL 588



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 50/166 (30%), Positives = 78/166 (46%), Gaps = 13/166 (7%)

Query: 33  TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVR 92
           TT   G + LH+AA  G       L+  G + +A+++   TPL+MAA + H  +V+ L+ 
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 93  NGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEI 152
           NGA+ N       T L  A ++ H +VV  LI YG       K    A  IA   ++   
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRT 188

Query: 153 LVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEVVNLASLI 198
             +L   +QN  N +       T P+ +AA +     E +N+A L+
Sbjct: 189 AAVL---LQNDPNPDVLSKTGFT-PLHIAAHY-----ENLNVAQLL 225



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 50/173 (28%), Positives = 84/173 (48%), Gaps = 7/173 (4%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           L  A ++G ++ V  L+  G   T   +    LH+AA+     TA VLL+   + D  +K
Sbjct: 148 LAVALQQGHENVVAHLINYG---TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+AA   + ++ +LL+  GA VN      +T LH A+ R +  +V LL+  GA 
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           +   +K + +    A    +  I  IL   + +   +  +  N ++ P+ MAA
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLS-PIHMAA 313



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 36/119 (30%), Positives = 58/119 (48%)

Query: 45  AAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLK 104
           AA+ G+   A   LR GV  +   +     LH+A+ +GH  +V  L+     +       
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 105 MTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQ 163
            TALH A      +VV  L+ YGA+V+A S+   +   +A ++N+ E++  L E   NQ
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 54/171 (31%), Positives = 94/171 (54%), Gaps = 5/171 (2%)

Query: 13  AARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           +AR+G +D    L+ +GA  + T   G +PLH+AA+YG    A +LL+   S DA  K  
Sbjct: 539 SAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSG 598

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA   +  +  LL+  GA  +A      T LH A +++  D+   L++YGAD +
Sbjct: 599 LTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN 658

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAA 182
           A ++   ++  +A ++ + +++ +L   +    NVN    + +T P+ +AA
Sbjct: 659 AVTRQGIASVHLAAQEGHVDMVSLL---LGRNANVNLSNKSGLT-PLHLAA 705



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 49/155 (31%), Positives = 82/155 (52%), Gaps = 1/155 (0%)

Query: 5   DLGKRLLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVS 63
           D     L AAR G  ++    + NG      +  G + LHLA++ GH      LL+   +
Sbjct: 40  DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 99

Query: 64  RDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELL 123
            DA TK   T LH+A+  G A +V++LV NGA+VNA+     T L+ A + +H +VV+ L
Sbjct: 100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159

Query: 124 IKYGADVHAFSKFDKSAFDIALEKNNAEILVILQE 158
           +  GA     ++   +   +AL++ + +++ +L E
Sbjct: 160 LDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE 194



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 54/147 (36%), Positives = 74/147 (50%), Gaps = 1/147 (0%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           +AR G+ D V+ L+  GA P      G +PLHL+A+ GH   A  LL  G S    TK  
Sbjct: 506 SARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKG 565

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA  G   +  LL++  A  +A     +T LH A    ++ V  LL+  GA  H
Sbjct: 566 FTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPH 625

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQE 158
           A +K   +   IA +KN  +I   L E
Sbjct: 626 AAAKNGYTPLHIAAKKNQMDIATTLLE 652



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 62/198 (31%), Positives = 100/198 (50%), Gaps = 18/198 (9%)

Query: 13  AARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA++G  D V  L+   A    ++  G +PLHLAAQ    + AEVL+  G   DA+TK+ 
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+    G+  IV  L+++ A VNAK     T LH A ++ H  ++ +L++  A  +
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790

Query: 132 AFSKFDKSAFDIALEKNNAEIL----VILQEAM-------QNQVNVNPERANPV----TD 176
             +    +A  IA       ++    ++ +E M       ++++NV PE  N V     D
Sbjct: 791 ELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNV-PETMNEVLDMSDD 849

Query: 177 PVSMA-APFIFTSGEVVN 193
            V  A AP + + GE ++
Sbjct: 850 EVRKANAPEMLSDGEYIS 867



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 49/145 (33%), Positives = 75/145 (51%), Gaps = 1/145 (0%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  G  + V  LM +GA P TT+  G + LH+AA+ G       L++ G   +A+ K D
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
           +TPLH++A  G A IV+ L++ GA  NA      T LH +    H DV   L+ +GA + 
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
             +K   +   +A +    E+  +L
Sbjct: 560 ITTKKGFTPLHVAAKYGKLEVANLL 584



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 53/161 (32%), Positives = 81/161 (50%), Gaps = 3/161 (1%)

Query: 14  ARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDR 72
           AR G +  V  L+   AP  +    G SPLH+A Q  H +  ++LL+  V  D  T    
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL 368

Query: 73  TPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHA 132
           T LH+AA  GH  + ++L+   A+ NAK +   T LH A +++   V+ELL+K+GA + A
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428

Query: 133 FSKFDKSAFDIALEKNNAEILVILQE--AMQNQVNVNPERA 171
            ++   +   +A    +  I+  L    A  N  NV  E A
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETA 469



 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 48/145 (33%), Positives = 77/145 (53%), Gaps = 4/145 (2%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+A +       E+LL+ G S  A T+   TP+H+AA  GH +IV  L+ +GA  
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           N  ++   TALH A      +VV  L++ GA V A +K D++   I+     A+   I+Q
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKAD---IVQ 516

Query: 158 EAMQNQVNVNPERANPVTDPVSMAA 182
           + +Q   + N    +  T P+ ++A
Sbjct: 517 QLLQQGASPNAATTSGYT-PLHLSA 540



 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 43/130 (33%), Positives = 74/130 (56%), Gaps = 3/130 (2%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLH+AA YG+ + A +LL    + D   + D TPLH+A+  G+A++V+LL+  GA +
Sbjct: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           +AK    +T LH      H  VVE+L+   A + + +K   S   +A + ++   + +L 
Sbjct: 295 DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLL- 353

Query: 158 EAMQNQVNVN 167
             +Q+ V V+
Sbjct: 354 --LQHNVPVD 361



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 85/350 (24%), Positives = 141/350 (40%), Gaps = 54/350 (15%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA+ G+ +    L+   A P      G +PLH+AA Y +   A +LL  G S  A  K  
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA      I   L+  GAD NA     + ++H A +  H D+V LL+   A+V+
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691

Query: 132 AFSKFDKSAFDIALEK---NNAEILV---------------------------ILQEAMQ 161
             +K   +   +A ++   N AE+LV                           I+   +Q
Sbjct: 692 LSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ 751

Query: 162 NQVNVNPERANPVTDPVSMAAPFIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNST 221
           +   VN +  N  T P+  AA    T   ++N+    +++  + T     A  +      
Sbjct: 752 HSAKVNAKTKNGYT-PLHQAAQQGHT--HIINVLLQNNASPNELTVNGNTALGIARRLGY 808

Query: 222 TSVLATLAALAEASVPLSNSHRATANTEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVP 281
            SV+ TL  + E           T  T  + E + +  ++ + M      V+ +  D V 
Sbjct: 809 ISVVDTLKIVTE----------ETMTTTTVTEKHKM--NVPETM----NEVLDMSDDEVR 852

Query: 282 LGNIQTSIPTGGIGQPFIVTVQDGQQVLTVPAGKVAEETVIKEEEEEKLP 331
             N    +  G     +I  V++G+  +T    K      +KE  ++ LP
Sbjct: 853 KANAPEMLSDG----EYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLP 898



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 44/145 (30%), Positives = 73/145 (50%), Gaps = 1/145 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGT-SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR GQ + VR L+ +GA          +PLH++A+ G     + LL+ G S +A T   
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH++A +GH  +   L+ +GA ++       T LH A +    +V  LL++  A   
Sbjct: 533 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 592

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
           A  K   +   +A   +N ++ ++L
Sbjct: 593 AAGKSGLTPLHVAAHYDNQKVALLL 617



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 53/191 (27%), Positives = 95/191 (49%), Gaps = 12/191 (6%)

Query: 22  VRTLMANGAPF---TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMA 78
           V+ L+ +  P    T D+L  + LH+AA  GHY  A+VLL    + +A+     TPLH+A
Sbjct: 350 VQLLLQHNVPVDDVTNDYL--TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIA 407

Query: 79  AADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDK 138
                  ++ELL+++GA + A     +T +H A    H ++V  L+ +GA  +  +   +
Sbjct: 408 CKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE 467

Query: 139 SAFDIALEKNNAEIL-VILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEVVNLASL 197
           +A  +A     AE++  ++Q+  Q +     ++      P+ ++A  +  +  V  L   
Sbjct: 468 TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQT-----PLHISAR-LGKADIVQQLLQQ 521

Query: 198 ISSTNTKTTSG 208
            +S N  TTSG
Sbjct: 522 GASPNAATTSG 532



 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 39/136 (28%), Positives = 72/136 (52%), Gaps = 3/136 (2%)

Query: 40  SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNA 99
           +PLH+A++ G+ +  ++LL  G   DA+T+   TPLH  A  GH  +VE+L+   A + +
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329

Query: 100 KDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEA 159
           K    ++ LH AT+  H + V+LL+++   V   +    +A  +A    + ++  +L   
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL--- 386

Query: 160 MQNQVNVNPERANPVT 175
           +  + N N +  N  T
Sbjct: 387 LDKKANPNAKALNGFT 402



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 41/145 (28%), Positives = 69/145 (47%), Gaps = 1/145 (0%)

Query: 13  AARKGQDDEVRTLMANGAPF-TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A +K +   +  L+ +GA        G +P+H+AA  GH +    L+  G S +      
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            T LHMAA  G A +V  LV++GA V AK     T LH +      D+V+ L++ GA  +
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
           A +    +   ++  + + ++   L
Sbjct: 527 AATTSGYTPLHLSAREGHEDVAAFL 551



 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 56/200 (28%), Positives = 99/200 (49%), Gaps = 10/200 (5%)

Query: 13  AARKGQDDEVRTLMANGAPF---TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           A+++G  + V+ L+  GA     T D  G +PLH  A+ GH    E+LL       ++TK
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRD--GLTPLHCGARSGHEQVVEMLLDRAAPILSKTK 332

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              +PLHMA    H + V+LL+++   V+      +TALH A    H  V ++L+   A+
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSG 189
            +A +    +   IA +KN  +++ +L   +++  ++     + +T P+ +AA F+    
Sbjct: 393 PNAKALNGFTPLHIACKKNRIKVMELL---LKHGASIQAVTESGLT-PIHVAA-FMGHVN 447

Query: 190 EVVNLASLISSTNTKTTSGD 209
            V  L    +S NT    G+
Sbjct: 448 IVSQLMHHGASPNTTNVRGE 467



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 43/145 (29%), Positives = 67/145 (46%), Gaps = 5/145 (3%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A+  GQ + V+ L+ NGA        G +PL++AAQ  H    + LL  G S+   T+  
Sbjct: 114 ASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDG 173

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPL +A   GH  +V LL+ N    + K  +++ ALH A  +       LL++   +  
Sbjct: 174 FTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLLQNDNNAD 229

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
             SK   +   IA    N  +  +L
Sbjct: 230 VESKSGFTPLHIAAHYGNINVATLL 254



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 48/195 (24%), Positives = 89/195 (45%), Gaps = 16/195 (8%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           L  A ++G D  V  L+ N    T   +    LH+AA+      A +LL+   + D  +K
Sbjct: 177 LAVALQQGHDQVVSLLLEND---TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESK 233

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
              TPLH+AA  G+ ++  LL+   A V+      +T LH A++R + ++V+LL+  GA 
Sbjct: 234 SGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAK 293

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPV--SMAAPFIFT 187
           + A ++   +         + +++ +L            +RA P+       ++   + T
Sbjct: 294 IDAKTRDGLTPLHCGARSGHEQVVEMLL-----------DRAAPILSKTKNGLSPLHMAT 342

Query: 188 SGEVVNLASLISSTN 202
            G+ +N   L+   N
Sbjct: 343 QGDHLNCVQLLLQHN 357


>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 2 [Homo sapiens]
          Length = 1390

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 51/150 (34%), Positives = 81/150 (54%), Gaps = 1/150 (0%)

Query: 10   LLEAARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDART 68
            L  AA +G+ +    L+ +GA  + T+  G  PL  AA+ GH+    +LL  G   +   
Sbjct: 1075 LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSD 1134

Query: 69   KVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGA 128
            K  RTPL +AA +GH   VE L+  GA +++ D   ++AL WA  + HR VV+ L++ GA
Sbjct: 1135 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGA 1194

Query: 129  DVHAFSKFDKSAFDIALEKNNAEILVILQE 158
             +    K  ++  D+A    +AE ++ L E
Sbjct: 1195 AIDQTDKNGRTPLDLAAFYGDAETVLYLVE 1224



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 45/145 (31%), Positives = 64/145 (44%), Gaps = 1/145 (0%)

Query: 13   AARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
            AAR+G    VR L+  G     +D  G +PL +AA  GH ST E LL  G +  +  K  
Sbjct: 1111 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1170

Query: 72   RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
             + L  A   GH  +V+ LV  GA ++  D    T L  A      + V  L++ GA + 
Sbjct: 1171 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1230

Query: 132  AFSKFDKSAFDIALEKNNAEILVIL 156
                      D A+   N  ++V L
Sbjct: 1231 HVDHSGMRPLDRAIGCRNTSVVVAL 1255



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 51/158 (32%), Positives = 74/158 (46%), Gaps = 9/158 (5%)

Query: 10   LLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDART 68
            L+ AA +G    V  L++ GA  ++ D  G S L  A   GH +  + L+  G + D   
Sbjct: 1141 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTD 1200

Query: 69   KVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGA 128
            K  RTPL +AA  G A  V  LV  GA +   D   M  L  A    +  VV  L++ GA
Sbjct: 1201 KNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260

Query: 129  DVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNV 166
                  K   +A+ +A  K   +IL+IL + +  + NV
Sbjct: 1261 ------KLGNAAWAMATSK--PDILIILLQKLMEEGNV 1290



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 51/162 (31%), Positives = 65/162 (40%), Gaps = 12/162 (7%)

Query: 6    LGKRLLEAARKGQDDEVRTLMA---------NGAPFTTDWLGTSPLHLAAQYGHYSTAEV 56
            L + L  AA  G    V+ L+          NG    T W G + L  AA  G     E+
Sbjct: 1033 LQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTD--TLW-GETALTAAAGRGKLEVCEL 1089

Query: 57   LLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHH 116
            LL  G +     +    PL  AA  GH  IV LL+  G DVN  D    T L  A    H
Sbjct: 1090 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGH 1149

Query: 117  RDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQE 158
               VE L+  GA + +  K   SA   A  K +  ++  L E
Sbjct: 1150 LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1191



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 33/105 (31%), Positives = 50/105 (47%), Gaps = 3/105 (2%)

Query: 23   RTLMANGAP--FTTDWLGTSP-LHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAA 79
            R L+  GA   + T+ L  +P L + +  GH     +LL  G   D  ++   T L  AA
Sbjct: 909  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968

Query: 80   ADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLI 124
            A GH  +V LL + G  V+  D     AL  +  R H D+++ L+
Sbjct: 969  AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLL 1013



 Score = 36.6 bits (83), Expect = 0.047
 Identities = 35/131 (26%), Positives = 58/131 (44%), Gaps = 10/131 (7%)

Query: 36   WLGTSPLHLAAQYG--------HYSTAEVLLRAGVSRDARTKV-DRTPLHMAAAD-GHAH 85
            W+G S   L+A           +   + +L+  G + + RT+V +  P+    +  GH  
Sbjct: 882  WIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEE 941

Query: 86   IVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIAL 145
            +V LL+  GA ++      MTAL +A    H  +V LL K G  V    K  + A   + 
Sbjct: 942  VVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSA 1001

Query: 146  EKNNAEILVIL 156
             + + +IL  L
Sbjct: 1002 LRGHGDILQYL 1012


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 51/150 (34%), Positives = 81/150 (54%), Gaps = 1/150 (0%)

Query: 10   LLEAARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDART 68
            L  AA +G+ +    L+ +GA  + T+  G  PL  AA+ GH+    +LL  G   +   
Sbjct: 1083 LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSD 1142

Query: 69   KVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGA 128
            K  RTPL +AA +GH   VE L+  GA +++ D   ++AL WA  + HR VV+ L++ GA
Sbjct: 1143 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGA 1202

Query: 129  DVHAFSKFDKSAFDIALEKNNAEILVILQE 158
             +    K  ++  D+A    +AE ++ L E
Sbjct: 1203 AIDQTDKNGRTPLDLAAFYGDAETVLYLVE 1232



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 45/145 (31%), Positives = 64/145 (44%), Gaps = 1/145 (0%)

Query: 13   AARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
            AAR+G    VR L+  G     +D  G +PL +AA  GH ST E LL  G +  +  K  
Sbjct: 1119 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1178

Query: 72   RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
             + L  A   GH  +V+ LV  GA ++  D    T L  A      + V  L++ GA + 
Sbjct: 1179 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1238

Query: 132  AFSKFDKSAFDIALEKNNAEILVIL 156
                      D A+   N  ++V L
Sbjct: 1239 HVDHSGMRPLDRAIGCRNTSVVVAL 1263



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 51/158 (32%), Positives = 74/158 (46%), Gaps = 9/158 (5%)

Query: 10   LLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDART 68
            L+ AA +G    V  L++ GA  ++ D  G S L  A   GH +  + L+  G + D   
Sbjct: 1149 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTD 1208

Query: 69   KVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGA 128
            K  RTPL +AA  G A  V  LV  GA +   D   M  L  A    +  VV  L++ GA
Sbjct: 1209 KNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268

Query: 129  DVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNV 166
                  K   +A+ +A  K   +IL+IL + +  + NV
Sbjct: 1269 ------KLGNAAWAMATSK--PDILIILLQKLMEEGNV 1298



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 51/162 (31%), Positives = 65/162 (40%), Gaps = 12/162 (7%)

Query: 6    LGKRLLEAARKGQDDEVRTLMA---------NGAPFTTDWLGTSPLHLAAQYGHYSTAEV 56
            L + L  AA  G    V+ L+          NG    T W G + L  AA  G     E+
Sbjct: 1041 LQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTD--TLW-GETALTAAAGRGKLEVCEL 1097

Query: 57   LLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHH 116
            LL  G +     +    PL  AA  GH  IV LL+  G DVN  D    T L  A    H
Sbjct: 1098 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGH 1157

Query: 117  RDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQE 158
               VE L+  GA + +  K   SA   A  K +  ++  L E
Sbjct: 1158 LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1199



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 33/105 (31%), Positives = 50/105 (47%), Gaps = 3/105 (2%)

Query: 23   RTLMANGAP--FTTDWLGTSP-LHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAA 79
            R L+  GA   + T+ L  +P L + +  GH     +LL  G   D  ++   T L  AA
Sbjct: 917  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976

Query: 80   ADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLI 124
            A GH  +V LL + G  V+  D     AL  +  R H D+++ L+
Sbjct: 977  AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLL 1021



 Score = 36.6 bits (83), Expect = 0.047
 Identities = 35/131 (26%), Positives = 58/131 (44%), Gaps = 10/131 (7%)

Query: 36   WLGTSPLHLAAQYG--------HYSTAEVLLRAGVSRDARTKV-DRTPLHMAAAD-GHAH 85
            W+G S   L+A           +   + +L+  G + + RT+V +  P+    +  GH  
Sbjct: 890  WIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEE 949

Query: 86   IVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIAL 145
            +V LL+  GA ++      MTAL +A    H  +V LL K G  V    K  + A   + 
Sbjct: 950  VVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSA 1009

Query: 146  EKNNAEILVIL 156
             + + +IL  L
Sbjct: 1010 LRGHGDILQYL 1020


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 56/148 (37%), Positives = 76/148 (51%), Gaps = 1/148 (0%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDART 68
           LL AA  G+   +R L+A GA     D  G + L LAA  G     EVLL  G     R 
Sbjct: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266

Query: 69  KVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGA 128
           +  R+ LH AAA GH   V+LLV  GA+V+A+D L +T LH A+   H +V   L+  GA
Sbjct: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGA 326

Query: 129 DVHAFSKFDKSAFDIALEKNNAEILVIL 156
            V A     K+   +A E+ +   + +L
Sbjct: 327 QVDATGWLRKTPLHLAAERGHGPTVGLL 354



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 46/117 (39%), Positives = 62/117 (52%), Gaps = 1/117 (0%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  G+  ++  L+ +GA P   D  G S LH AA  GH    ++L+  G   DAR  + 
Sbjct: 243 AAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLG 302

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGA 128
            TPLH A+ +GH  +   L+  GA V+A   L+ T LH A ER H   V LL+  GA
Sbjct: 303 LTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 49/121 (40%), Positives = 60/121 (49%), Gaps = 5/121 (4%)

Query: 13  AARKGQDDEVRTLMANGAPF-TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A  +G    VR L+  GAP    D  G + LH AA +GH   AE+LL+ G S  AR+   
Sbjct: 81  AVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTG 140

Query: 72  RTPLHMAAADGH----AHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYG 127
            TPLH AAA GH    A ++E      A   A+D    TA HWA       V+ELL   G
Sbjct: 141 LTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGG 200

Query: 128 A 128
           A
Sbjct: 201 A 201



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 43/116 (37%), Positives = 57/116 (49%), Gaps = 1/116 (0%)

Query: 2   SLVDLGKRLLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRA 60
           S+V     LL+A  +G    V  L+  GA     D  G +PLHLA   GH     +LL+ 
Sbjct: 37  SVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQR 96

Query: 61  GVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHH 116
           G    A  +  RT LH AA  GH+ + ELL++ GA   A+    +T LHWA    H
Sbjct: 97  GAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGH 152



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 37/78 (47%), Positives = 44/78 (56%)

Query: 57  LLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHH 116
           LLR G S + R    RTPLH+A   GHA +V LL++ GA V A D    TALH A    H
Sbjct: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119

Query: 117 RDVVELLIKYGADVHAFS 134
             V ELL++ GA   A S
Sbjct: 120 SRVAELLLQRGASAAARS 137



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 25/61 (40%), Positives = 33/61 (54%), Gaps = 1/61 (1%)

Query: 10  LLEAARKGQDDEVRTLMANGAPF-TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDART 68
           L  A+R+G  +    L+  GA    T WL  +PLHLAA+ GH  T  +LL  G S   RT
Sbjct: 306 LHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRT 365

Query: 69  K 69
           +
Sbjct: 366 Q 366



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 25/75 (33%), Positives = 38/75 (50%)

Query: 82  GHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAF 141
           G A +V  L+R GA V  +D    T LH A  R H  +V LL++ GA V A  +  ++A 
Sbjct: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111

Query: 142 DIALEKNNAEILVIL 156
             A    ++ +  +L
Sbjct: 112 HEAAWHGHSRVAELL 126


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 50/145 (34%), Positives = 77/145 (53%), Gaps = 1/145 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G  D ++ L  N  P    D  G   LH+AA+YGH   A++L   G + + + K +
Sbjct: 419 AARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE 478

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH AA  G+  + + L   G +VN K+    T L  A+ R + D+VE L ++GAD++
Sbjct: 479 ETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLN 538

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
           A  K    A  +A+ +   E++  L
Sbjct: 539 ACDKDGHIALHLAVRRCQMEVIKTL 563



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 54/151 (35%), Positives = 78/151 (51%), Gaps = 1/151 (0%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G  D  + L + G+ P   D    +PLH AA +G+YS A+ L  AG + + + +  
Sbjct: 452 AARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREG 511

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPL  A+A G+  IVE L  +GAD+NA D     ALH A  R   +V++ L+  G  V 
Sbjct: 512 ETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVD 571

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQN 162
              +   +   +A +  N  I+V L EA  N
Sbjct: 572 YQDRHGNTPLHVACKDGNMPIVVALCEANCN 602



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 46/148 (31%), Positives = 66/148 (44%), Gaps = 1/148 (0%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDART 68
           LL A+ +G  D V  L  +GA     D  G   LHLA +       + LL  G   D + 
Sbjct: 515 LLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQD 574

Query: 69  KVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGA 128
           +   TPLH+A  DG+  IV  L     +++  +    T LH A      DVV  L   GA
Sbjct: 575 RHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGA 634

Query: 129 DVHAFSKFDKSAFDIALEKNNAEILVIL 156
            V A +   K+A D+A  + +  +  +L
Sbjct: 635 SVEALTTDGKTAEDLARSEQHEHVAGLL 662



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 40/120 (33%), Positives = 55/120 (45%), Gaps = 1/120 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A R+ Q + ++TL++ G      D  G +PLH+A + G+      L  A  + D   K  
Sbjct: 551 AVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYG 610

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
           RTPLH+AA +G   +V  L   GA V A      TA   A    H  V  LL +   D H
Sbjct: 611 RTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTH 670



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 38/137 (27%), Positives = 61/137 (44%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           GT PL +AA  G+    ++L++ G   D + K     ++ AA  GH   ++ L  N   +
Sbjct: 379 GTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPL 438

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           + KD     ALH A    H DV +LL  +G++ +   K +++    A       +   L 
Sbjct: 439 DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALC 498

Query: 158 EAMQNQVNVNPERANPV 174
           EA  N    N E   P+
Sbjct: 499 EAGCNVNIKNREGETPL 515


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 51/121 (42%), Positives = 69/121 (57%), Gaps = 3/121 (2%)

Query: 37  LGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGAD 96
           L  +PLH+AA+ GH STA +LL  G  ++A T    T LH+AA +GH   V+LLV   AD
Sbjct: 636 LAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKAD 695

Query: 97  VNAKDMLKMTALHWATERHHRDVVELLIKYGADV-HAFSKFDKSAFDIALEKNNAEILVI 155
           V A+  L  TALH A    H +VVE L+   ADV   F +   SA  +A +  +A+ +  
Sbjct: 696 VLARGPLNQTALHLAAAHGHSEVVEELV--SADVIDLFDEQGLSALHLAAQGRHAQTVET 753

Query: 156 L 156
           L
Sbjct: 754 L 754



 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 51/151 (33%), Positives = 74/151 (49%), Gaps = 8/151 (5%)

Query: 13  AARKGQDDEVRTLMANGAPFTTD----WLGTSPLHLAAQYGHYSTAEVLLRA-GVSRDAR 67
           A + GQ++ VR L+  G   +      WL   PLH AA  GH    ++L +  GVS +A+
Sbjct: 544 ACQHGQENIVRILLRRGVDVSLQGKDAWL---PLHYAAWQGHLPIVKLLAKQPGVSVNAQ 600

Query: 68  TKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYG 127
           T   RTPLH+AA  GH  +  +L+   +DVN   +L  T LH A E  H     LL+  G
Sbjct: 601 TLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRG 660

Query: 128 ADVHAFSKFDKSAFDIALEKNNAEILVILQE 158
           A   A +    +A  +A    +   + +L E
Sbjct: 661 AGKEAMTSDGYTALHLAARNGHLATVKLLVE 691



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 44/122 (36%), Positives = 64/122 (52%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLHLAAQ GHY  A +L+      +  + + +TPLH+AA  GH     LL+  GA  
Sbjct: 604 GRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGK 663

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
            A      TALH A    H   V+LL++  ADV A    +++A  +A    ++E++  L 
Sbjct: 664 EAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV 723

Query: 158 EA 159
            A
Sbjct: 724 SA 725



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 89/343 (25%), Positives = 146/343 (42%), Gaps = 55/343 (16%)

Query: 4   VDLGKRLLE-AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAG 61
           +D G  LL  A   GQ++  + L+ N A P  ++  G++PLH+A +       E+LL   
Sbjct: 435 LDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARK 494

Query: 62  VSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVE 121
           +S +A+ +   T LH AA +G      LL+   A VN  D    T +H A +    ++V 
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554

Query: 122 LLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMA 181
           +L++ G DV    K        A  + +  I+ +L  A Q  V+VN +  +  T P+ +A
Sbjct: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL--AKQPGVSVNAQTLDGRT-PLHLA 611

Query: 182 AP--------FIFTSGEVVNLASLISSTNTKTTSGDPHASTVQF------------SNST 221
           A          +      VN+ SL++ T     +   H ST +             S+  
Sbjct: 612 AQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY 671

Query: 222 TSV--------LATLAALAE------ASVPLSNS--HRATAN-----TEEIIEGNSVDSS 260
           T++        LAT+  L E      A  PL+ +  H A A+      EE++  + +D  
Sbjct: 672 TALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLF 731

Query: 261 IQQ--------VMGSGGQRVITIVTDGVPLGNIQTSIPTGGIG 295
            +Q          G   Q V T++  G  + N+Q+    GG G
Sbjct: 732 DEQGLSALHLAAQGRHAQTVETLLRHGAHI-NLQSLKFQGGHG 773


>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
          Length = 1050

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 52/146 (35%), Positives = 79/146 (54%), Gaps = 3/146 (2%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGTS-PLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  G+ D +  L+ +GA         + PLHLA Q GH+   + LL +    + +    
Sbjct: 751 AALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSG 810

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPL  A + GH  +V LL+++GA +NA +    TALH A    H  VVELL+ +GA V 
Sbjct: 811 NTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQ 870

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQ 157
             +K  ++A D A  + N++I+ +LQ
Sbjct: 871 VLNKRQRTAVDCA--EQNSKIMELLQ 894



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 38/119 (31%), Positives = 66/119 (55%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G+SPLH+AA +G      +LL+ G +  AR      PLH+A   GH  +V+ L+ + A  
Sbjct: 744 GSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP 803

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVIL 156
           N KD+   T L +A    H ++V LL+++GA ++A +    +A   A+ + +  ++ +L
Sbjct: 804 NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELL 862



 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 54/201 (26%), Positives = 89/201 (44%), Gaps = 8/201 (3%)

Query: 13  AARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  GQ   +  L++ GA    TD+ G +PLHLA Q G+ S   +LL    S + +    
Sbjct: 470 AAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNG 529

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKM---TALHWATERHHRDVVELLIKYGA 128
            TPLH+A   GH   V+ LV    +    D+      T LH A    ++ V+E L++ GA
Sbjct: 530 NTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGA 589

Query: 129 DVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTS 188
                ++  ++    AL   N++IL +++    +          PV  P   +   I   
Sbjct: 590 STEIQNRLKETPLKCAL---NSKILSVMEAYHLSFERRQKSSEAPVQSP-QRSVDSISQE 645

Query: 189 GEVVNLASLISSTNTKTTSGD 209
               + +S+ +S+  + T  D
Sbjct: 646 SSTSSFSSMSASSRQEETKKD 666



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 33/99 (33%), Positives = 48/99 (48%)

Query: 31  PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELL 90
           PF+ D  G +PLH+AA  G  S  ++L+  G   +A      TPLH+A   G+  +  LL
Sbjct: 456 PFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLL 515

Query: 91  VRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
           +   A    +D    T LH A    H D V+ L+ Y  +
Sbjct: 516 LHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVE 554



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 26/108 (24%), Positives = 56/108 (51%), Gaps = 3/108 (2%)

Query: 60  AGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDV 119
           +G+  +  ++   +PLH+AA  G A ++ LL+++GA+  A++  +   LH A ++ H  V
Sbjct: 733 SGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQV 792

Query: 120 VELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVN 167
           V+ L+   A  +       +    A    + E++ +L   +Q+  ++N
Sbjct: 793 VKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALL---LQHGASIN 837


>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
          Length = 305

 Score = 79.0 bits (193), Expect = 8e-15
 Identities = 54/164 (32%), Positives = 83/164 (50%), Gaps = 6/164 (3%)

Query: 11  LEAARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           L+AA + Q+  +   + +G  P   D L  + LH A   GH      LL AG + DAR  
Sbjct: 116 LKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDL 175

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
           +DRTP+  A   GH  I++ L+  GA VNA+D +  T LH A    H D +E LI+ GA 
Sbjct: 176 LDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAH 235

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVIL-----QEAMQNQVNVNP 168
           ++A  K   +A   A+   + + + +L     +  ++N  +V P
Sbjct: 236 LNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTP 279



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 1/102 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A R G    ++ L+  GA     D +G++PLH+A +  H    E L+  G   +A+ K  
Sbjct: 184 ACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEG 243

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATE 113
            T LH A   G    ++LL+  GA++  ++   +T +  A +
Sbjct: 244 DTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARD 285


>gi|103471993 huntingtin interacting protein 14 [Homo sapiens]
          Length = 632

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 60/159 (37%), Positives = 80/159 (50%), Gaps = 3/159 (1%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A R+G    V  LM  GA P   D  G S +HLAAQ+GH S    L+  G   D   +  
Sbjct: 131 ATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNG 190

Query: 72  RTPLHMAAADGHA-HIVELLVRNGADVNAKDML-KMTALHWATERHHRDVVELLIKYGAD 129
            TPL  AA   H+     LL+     VN  D   K TALHWA    +  V+ LL++ GA+
Sbjct: 191 MTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGAN 250

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNP 168
           V A +   +SA D+A ++ N  ++  LQEA Q +   NP
Sbjct: 251 VDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNP 289



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 50/156 (32%), Positives = 73/156 (46%), Gaps = 8/156 (5%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLG----TSPLHLAAQYGHYSTAEVLLRAGVSRDART 68
           AA   + D V+  ++ GA    D LG    ++PLH A + GH S    L++ G       
Sbjct: 97  AAINNRIDLVKYYISKGA--IVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLID 154

Query: 69  KVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHR-DVVELLIKYG 127
               + +H+AA  GH  IV  L+  G DV+  D   MT L WA  R H  D   LL+ + 
Sbjct: 155 GEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFN 214

Query: 128 ADVHAFSKFDK-SAFDIALEKNNAEILVILQEAMQN 162
             V+   K+ K +A   A+   N  ++ +L EA  N
Sbjct: 215 VSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGAN 250



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 37/113 (32%), Positives = 51/113 (45%), Gaps = 1/113 (0%)

Query: 45  AAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDM-L 103
           A QYG Y     L+ AG       K + T LH AA +    +V+  +  GA V+     L
Sbjct: 64  ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123

Query: 104 KMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVIL 156
             T LHWAT + H  +V  L+KYGAD         S   +A +  +  I+  L
Sbjct: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYL 176


>gi|239747812 PREDICTED: ankyrin repeat domain 36 [Homo sapiens]
          Length = 753

 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 60/200 (30%), Positives = 97/200 (48%), Gaps = 3/200 (1%)

Query: 10  LLEAARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDART 68
           L++A +  Q+     L+ NGA P  TD+ G + LH A      S  E LL  G + +  +
Sbjct: 423 LIKAVQLRQEACATLLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECS 482

Query: 69  KVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGA 128
           K +  PL  A +     +VE L++  A+VNA D L  +AL  A     +D+V LL+++  
Sbjct: 483 KCEYQPLLFAVSRRKVKMVEFLLKKKANVNAIDYLGRSALIHAVTLGEKDIVILLLQHNI 542

Query: 129 DVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTS 188
           DV +   F K A D A+E  N  I  ++ E  + +    P  +NPV+     A     TS
Sbjct: 543 DVLSRDAFRKIAGDYAIEAKNRVIFDLIYEYKRKRYEDLPINSNPVSSQKQPALK--ATS 600

Query: 189 GEVVNLASLISSTNTKTTSG 208
           G+  +++++ +       SG
Sbjct: 601 GKEDSISNIATEIKDGQKSG 620



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 34/126 (26%), Positives = 57/126 (45%), Gaps = 3/126 (2%)

Query: 42  LHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKD 101
           LHLA   G      +L+      +   + DRTPL  A          LL++NGA+ N  D
Sbjct: 390 LHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGANPNITD 449

Query: 102 MLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQ 161
               TALH+A       ++E L+ +G ++   SK +      A+ +   +++  L   ++
Sbjct: 450 FFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKVKMVEFL---LK 506

Query: 162 NQVNVN 167
            + NVN
Sbjct: 507 KKANVN 512



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 39/155 (25%), Positives = 71/155 (45%), Gaps = 4/155 (2%)

Query: 13  AARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A   GQ + V  L++        D    +PL  A Q    + A +LL+ G + +      
Sbjct: 393 ACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGANPNITDFFG 452

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
           RT LH A  +    ++E L+ +G ++      +   L +A  R    +VE L+K  A+V+
Sbjct: 453 RTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKVKMVEFLLKKKANVN 512

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNV 166
           A     +SA   A+     +I+++L   +Q+ ++V
Sbjct: 513 AIDYLGRSALIHAVTLGEKDIVILL---LQHNIDV 544


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 99/411 (24%), Positives = 178/411 (43%), Gaps = 52/411 (12%)

Query: 10  LLEAARKGQDDEVRTLMANGAPF-TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDART 68
           L+EAA++G  + V+ L+A GA    T   G + L  A + GH   A+VLL+AG   +  +
Sbjct: 568 LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 627

Query: 69  KVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLK-MTALHWATERHHRDVVELLIKYG 127
           +  RTPL  AA  GH   V+ L+  GA+VN        T L  A    H  VVELL+ +G
Sbjct: 628 EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687

Query: 128 ADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFT 187
           AD     K   +    A +  +  ++  L +   N ++  P     +T P          
Sbjct: 688 ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPP-----SHDLN 742

Query: 188 SGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSNSHRATAN 247
               V + +L      +     P            +V  TL    +A+    +S    AN
Sbjct: 743 RAPRVPVQALPMVVPPQEPDKPP-----------ANVATTLPIRNKAASKQKSSSHLPAN 791

Query: 248 TEEI---IEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPFIVTVQD 304
           ++++   I   S +S +++  G         +T+               + Q     ++ 
Sbjct: 792 SQDVQGYITNQSPESIVEEAQGK--------LTE---------------LEQRIKEAIEK 828

Query: 305 GQQVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNEREL---LQQQL 361
             Q+ ++   ++A    + +E+ E+L  T++ +I +K   +EE ++  EREL    QQQL
Sbjct: 829 NAQLQSL---ELAHADQLTKEKIEELNKTREEQIQKKQKILEELQK-VERELQLKTQQQL 884

Query: 362 QEANRRAQEYRHQLLKKEQEAEQYRLKLEAI-ARQQPNGVDFTMVEEVAEV 411
           ++     +  R QL +++Q++ Q+   L  +   +Q +  D+  +++V  V
Sbjct: 885 KKQYLEVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPV 935



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 48/119 (40%), Positives = 64/119 (53%), Gaps = 3/119 (2%)

Query: 10   LLEAARKGQDDEVRTLMANGAPFTTDWLGTS---PLHLAAQYGHYSTAEVLLRAGVSRDA 66
            L+EAA  G  +  R L+  GA      + +S    L +AA  GHY   E+L+  G   D 
Sbjct: 1289 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDV 1348

Query: 67   RTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIK 125
            R K   TPL +AA  GH  +V+LLV+ GADV+A D  K+T L  A  + H  VV  L+K
Sbjct: 1349 RNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 56/206 (27%), Positives = 98/206 (47%), Gaps = 9/206 (4%)

Query: 10   LLEAARKGQDDEVRTLMANGAPFTTDWLGT--SPLHLAAQYGHYSTAEVLLRAGVSRDAR 67
            L+ AA  G    V  L+ NGA        T  +PL LA   G     E+LL  G +++ R
Sbjct: 1120 LILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR 1179

Query: 68   TKVDRTPLHMAAADGHAHIVELLVRNGADVNAK--DMLKMTALHWATERHHRDVVELLIK 125
               D TPL +AA+ G+ +I+++L+  GA++N++    L ++ L  A    H   V+LL+ 
Sbjct: 1180 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD 1239

Query: 126  YGADVHAFSKFDK-SAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVS----M 180
             G+D++A  + ++ +A  +A  +   E++ +L +   N  +       P+ +  S     
Sbjct: 1240 MGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1299

Query: 181  AAPFIFTSGEVVNLASLISSTNTKTT 206
                +   G  VN   + SS +T  T
Sbjct: 1300 VGRVLLDKGADVNAPPVPSSRDTALT 1325



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 5/162 (3%)

Query: 8   KRLLEAARKGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVS-RD 65
           + L EA  +G  + VR L+  G         G S L LA   G+Y  A+VLL    +  D
Sbjct: 236 RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 295

Query: 66  ARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIK 125
              K D TPL  AA  GH  IV+LL+ + ADVNA+     TAL +A    + DVV++L++
Sbjct: 296 RGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLE 355

Query: 126 YGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVN 167
            GA +      +++     +E  +A  + + +  ++N   +N
Sbjct: 356 SGASI---EDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN 394



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 62/216 (28%), Positives = 93/216 (43%), Gaps = 9/216 (4%)

Query: 42   LHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAK- 100
            L LA   GH    + LL  G S + R K   TPL +AA  GH  +VE+L+ NGAD+ A+ 
Sbjct: 1087 LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 1146

Query: 101  DMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAM 160
            +  K T L  A     ++VVELL+  GA+    +  D +   +A       I+ IL  A 
Sbjct: 1147 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA- 1205

Query: 161  QNQVNVNPERANPVTDPVSMAAPFIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNS 220
                 +N    + +     M A     +  V  L  + S  N +  +    A T+     
Sbjct: 1206 --GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263

Query: 221  TTSVLATLAALAEASVPLSNSHRATANTEEIIEGNS 256
             T V++ L    +A+V     HRA      ++E  S
Sbjct: 1264 RTEVVSLLLD-RKANV----EHRAKTGLTPLMEAAS 1294



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 108/458 (23%), Positives = 184/458 (40%), Gaps = 77/458 (16%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTTDWLG-TSPLHLAAQYGHYSTAEVLLRAGVSRDART 68
           L+EA   G  +  R L+ +GA          SPL LAA  GH   A +L+  G S +   
Sbjct: 438 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN 497

Query: 69  KVDRTPLHMAAADGHAHIVELLVRNGADVNAK---------------------------- 100
               TPL  AA +GH  +V LL+  GA++NA+                            
Sbjct: 498 DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAG 557

Query: 101 ---DMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
              ++   T L  A +  H ++V+ L+  GA+VHA +    +A   A E  + ++  +L 
Sbjct: 558 ADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL- 616

Query: 158 EAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEVVNLASLIS---STNTKTTSGDPHAST 214
             +Q   ++  E     T P+  AA     +G V  +  LIS   + N  T + D    +
Sbjct: 617 --LQAGADLEHESEGGRT-PLMKAA----RAGHVCTVQFLISKGANVNRTTANNDHTVLS 669

Query: 215 VQFSNSTTSVLATLAALAEASVPLSNSHRATANTEEIIE-GNSVDSSIQQVMGSGGQRVI 273
           +  +    +V+  L  LA  + P   +HR    +  +IE      +S+   +      ++
Sbjct: 670 LACAGGHLAVVELL--LAHGADP---THRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLL 724

Query: 274 TI----VTDGVPLGNIQTSIPTGGI-GQPFIVTVQDGQQ-----VLTVPAGKVAEETVIK 323
           +     VT   P  +     P   +   P +V  Q+  +       T+P   +  +   K
Sbjct: 725 SAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLP---IRNKAASK 781

Query: 324 EEEEEKLPLTKKPRIGEKTN----SVEESKEGNERELLQQQLQEANRRAQ----EYRH-Q 374
           ++    LP   +   G  TN    S+ E  +G   EL Q+  +   + AQ    E  H  
Sbjct: 782 QKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHAD 841

Query: 375 LLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVD 412
            L KE+  E  + + E I ++Q       ++EE+ +V+
Sbjct: 842 QLTKEKIEELNKTREEQIQKKQ------KILEELQKVE 873



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 38/122 (31%), Positives = 67/122 (54%), Gaps = 2/122 (1%)

Query: 13   AARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDART-KV 70
            A   G ++ V+TL+  GA     D  G +PL LAA  GH    E+LL  G   +A++ + 
Sbjct: 1090 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 1149

Query: 71   DRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADV 130
              TPL +A + G   +VELL+  GA+   +++   T L  A    + +++++L+  GA++
Sbjct: 1150 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 1209

Query: 131  HA 132
            ++
Sbjct: 1210 NS 1211



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 55/218 (25%), Positives = 90/218 (41%), Gaps = 16/218 (7%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFTT--DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDAR 67
           L+EA   G  +  R L+ NGA   T  +    S L LA   GH      LL AG  ++ +
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHK 430

Query: 68  TKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYG 127
           T    T L  A  DGH  +  LL+ +GA VN       + L  A    H ++  LLI+ G
Sbjct: 431 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 490

Query: 128 ADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMA------ 181
           A +   +    +    A  + + E++ +L   +    N+N +        +++A      
Sbjct: 491 ASLEEVNDEGYTPLMEAAREGHEEMVALL---LGQGANINAQTEETQETALTLACCGGFL 547

Query: 182 --APFIFTSGEVVNLASLISSTNTKTTSGDPHASTVQF 217
             A F+  +G  + L     ST     + + H   V++
Sbjct: 548 EVADFLIKAGADIELG---CSTPLMEAAQEGHLELVKY 582



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 39/131 (29%), Positives = 66/131 (50%), Gaps = 1/131 (0%)

Query: 40  SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNA 99
           +PL  AA  GH    ++LL      +A++    T L  A A G+  +V++L+ +GA +  
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 100 KDMLKMTALHWATERHHRDVVELLIKYGADVHAFS-KFDKSAFDIALEKNNAEILVILQE 158
            +    T L  A    H +V  LL++ GA ++  S +F +SA  +A  K + E++  L E
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422

Query: 159 AMQNQVNVNPE 169
           A  +Q +   E
Sbjct: 423 AGADQEHKTDE 433



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 60/229 (26%), Positives = 96/229 (41%), Gaps = 47/229 (20%)

Query: 13   AARKGQDDEVRTLMANGAPF---TTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
            AA  G  + ++ L+  GA     T   LG SPL LAA  GH +  ++LL  G   +A+ +
Sbjct: 1190 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIE 1249

Query: 70   VDR----------------------------------TPLHMAAADGHAHIVELLVRNGA 95
             +R                                  TPL  AA+ G+A +  +L+  GA
Sbjct: 1250 TNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1309

Query: 96   DVNAKDM--LKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEIL 153
            DVNA  +   + TAL  A ++ H    ELLI  GA +   +K   +   +A    + +++
Sbjct: 1310 DVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVV 1369

Query: 154  VILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEVVNLASLISSTN 202
             +L +A  +    +  +  P+     MAA   F  G V  +  L+   N
Sbjct: 1370 QLLVQAGADVDAADNRKITPL-----MAA---FRKGHVKVVRYLVKEVN 1410



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 44/147 (29%), Positives = 72/147 (48%), Gaps = 15/147 (10%)

Query: 65   DARTKVDR-TPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELL 123
            DA+T+ +  T L +A A GH  +V+ L+  GA +  +D    T L  A    H  VVE+L
Sbjct: 1076 DAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEIL 1135

Query: 124  IKYGADVHAFSKFDK-SAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTD--PVSM 180
            +  GAD+ A S+  K +   +A      E++ +L     N+ + N      V+D  P+S+
Sbjct: 1136 LDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRN------VSDYTPLSL 1189

Query: 181  AAPFIFTSGEVVNLASLISSTNTKTTS 207
            AA     SG  VN+  ++ +   +  S
Sbjct: 1190 AA-----SGGYVNIIKILLNAGAEINS 1211


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 49/151 (32%), Positives = 76/151 (50%), Gaps = 1/151 (0%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           A  +G+   ++ L+ +GA P   D  G  PLH AA  G Y   ++LLR G S +  T   
Sbjct: 534 AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG 593

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
            TPLH+AA  GH  I+ LL  + A++ A   +  T LH A       VV  L++ GAD +
Sbjct: 594 WTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPN 653

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQN 162
           A  +   +   +A++++    ++ L E   N
Sbjct: 654 AAEQSGWTPLHLAVQRSTFLSVINLLEHHAN 684



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 51/145 (35%), Positives = 74/145 (51%), Gaps = 1/145 (0%)

Query: 10  LLEAARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDART 68
           LL AA+  Q D    L+A+GA     D  G +PLH AAQ G   TA +LL  G   DA+ 
Sbjct: 399 LLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQE 458

Query: 69  KVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGA 128
           +   TPLH+AA +   ++  LLV   AD N  +    T LH A    H  +V+LL   GA
Sbjct: 459 REGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGA 518

Query: 129 DVHAFSKFDKSAFDIALEKNNAEIL 153
           ++ A  +  ++   +A+E+     +
Sbjct: 519 ELDAQQRNLRTPLHLAVERGKVRAI 543



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 46/151 (30%), Positives = 79/151 (52%), Gaps = 1/151 (0%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA+   ++  R L++  A P   +  G +PLH+AA +GH S  ++L   G   DA+ +  
Sbjct: 468 AAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL 527

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
           RTPLH+A   G    ++ L+++GA  +A D      LH A  R    + ++L++YGA + 
Sbjct: 528 RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLE 587

Query: 132 AFSKFDKSAFDIALEKNNAEILVILQEAMQN 162
             +    +   +A  K + EI+ +L E+  N
Sbjct: 588 LPTHQGWTPLHLAAYKGHLEIIHLLAESHAN 618



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 46/122 (37%), Positives = 65/122 (53%)

Query: 38  GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADV 97
           G +PLHLAA  GH     +L  +  +  A   V+ TPLH+AA  G   +V  L++ GAD 
Sbjct: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP 652

Query: 98  NAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQ 157
           NA +    T LH A +R     V  L+++ A+VHA +K   +   +A  K N  IL +L 
Sbjct: 653 NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLV 712

Query: 158 EA 159
           EA
Sbjct: 713 EA 714



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 42/117 (35%), Positives = 62/117 (52%), Gaps = 1/117 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA+ G D   R L+ +GA     +  G +PLHLAAQ    + A +L+      +      
Sbjct: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGA 128
           +TPLH+AA  GH  +V+LL   GA+++A+     T LH A ER     ++ L+K GA
Sbjct: 495 KTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGA 551



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 38/112 (33%), Positives = 58/112 (51%), Gaps = 1/112 (0%)

Query: 13  AARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AAR G++  V  L+  GA P   +  G +PLHLA Q   + +   LL    +  AR KV 
Sbjct: 633 AARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVG 692

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELL 123
            TP H+AA  G+  I+++LV  GA ++ +D +  T L  A     + ++  L
Sbjct: 693 WTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score = 55.8 bits (133), Expect = 8e-08
 Identities = 41/145 (28%), Positives = 65/145 (44%), Gaps = 1/145 (0%)

Query: 13  AARKGQDDEVRTLMANGAPFTTDWLGT-SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
           AA  G    V+ L + GA          +PLHLA + G     + LL++G   DA  +  
Sbjct: 501 AAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSG 560

Query: 72  RTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVH 131
             PLH AAA G   I ++L+R GA +        T LH A  + H +++ LL +  A++ 
Sbjct: 561 YGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMG 620

Query: 132 AFSKFDKSAFDIALEKNNAEILVIL 156
           A    + +   +A       ++  L
Sbjct: 621 ALGAVNWTPLHLAARHGEEAVVSAL 645



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 42/145 (28%), Positives = 63/145 (43%), Gaps = 4/145 (2%)

Query: 40  SPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNA 99
           +PLH     G      +LL   V  D +T    TPL +AA D    +  LL+ +GAD N 
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 100 KDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEA 159
            D      LH+A +        LL+ +GA V A  +   +   +A + N   +  +L   
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL--- 480

Query: 160 MQNQVNVNPERANPVTDPVSMAAPF 184
           +  Q + N   A   T P+ +AA F
Sbjct: 481 VSRQADPNLHEAEGKT-PLHVAAYF 504



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 39/149 (26%), Positives = 71/149 (47%), Gaps = 7/149 (4%)

Query: 13  AARKGQDDEVRTLMAN----GAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDART 68
           AA KG  + +  L  +    GA    +W   +PLHLAA++G  +    LL+ G   +A  
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNW---TPLHLAARHGEEAVVSALLQCGADPNAAE 656

Query: 69  KVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGA 128
           +   TPLH+A        V  L+ + A+V+A++ +  T  H A  + +  ++++L++ GA
Sbjct: 657 QSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA 716

Query: 129 DVHAFSKFDKSAFDIALEKNNAEILVILQ 157
            +        +   +AL      I+  L+
Sbjct: 717 QLDVQDGVSCTPLQLALRSRKQGIMSFLE 745



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 38/142 (26%), Positives = 65/142 (45%), Gaps = 1/142 (0%)

Query: 16  KGQDDEVRTLMANGAPFTTDWL-GTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTP 74
           +G  ++VR L+A+          G +PL +AAQ        +LL  G   +   +    P
Sbjct: 372 QGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431

Query: 75  LHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFS 134
           LH AA +G      LL+ +GA V+A++    T LH A + +  +V  LL+   AD +   
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491

Query: 135 KFDKSAFDIALEKNNAEILVIL 156
              K+   +A    +  ++ +L
Sbjct: 492 AEGKTPLHVAAYFGHVSLVKLL 513


>gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]
          Length = 327

 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 53/161 (32%), Positives = 80/161 (49%), Gaps = 7/161 (4%)

Query: 3   LVDLG--KRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLH-----LAAQYGHYSTAE 55
           ++D+G  + L+E  +K +  +   L A+  P       T P+       AA  G     E
Sbjct: 106 IIDVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIE 165

Query: 56  VLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERH 115
             L  G S D   +  RT LH A+ +GH  I+E L+ NGA V+ +D L  TA+HWA    
Sbjct: 166 KFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGG 225

Query: 116 HRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVIL 156
           H +VV+LL  +GAD +   K   +A   A+  N  +I+ +L
Sbjct: 226 HLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLL 266



 Score = 72.4 bits (176), Expect = 8e-13
 Identities = 44/134 (32%), Positives = 71/134 (52%), Gaps = 1/134 (0%)

Query: 11  LEAARKGQDDEVRTLMANGAPFTT-DWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTK 69
           L+AA +G+   +   +A+G    T D    + LH A+  GH    E LL  G + D + +
Sbjct: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
           +D T +H A   GH  +V+LL  +GAD N +D    TALH A   +   +++LL+ +GAD
Sbjct: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGAD 272

Query: 130 VHAFSKFDKSAFDI 143
           +   +   K+  D+
Sbjct: 273 MMTKNLAGKTPTDL 286



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 25/88 (28%), Positives = 43/88 (48%)

Query: 70  VDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGAD 129
           VD      AA +G   ++E  + +G   +  D  + TALH A+   H +++E L+  GA 
Sbjct: 147 VDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206

Query: 130 VHAFSKFDKSAFDIALEKNNAEILVILQ 157
           V    + D +A   A    + E++ +LQ
Sbjct: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQ 234


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.126    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,147,734
Number of Sequences: 37866
Number of extensions: 668847
Number of successful extensions: 7803
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 470
Number of HSP's successfully gapped in prelim test: 329
Number of HSP's that attempted gapping in prelim test: 3599
Number of HSP's gapped (non-prelim): 3281
length of query: 448
length of database: 18,247,518
effective HSP length: 106
effective length of query: 342
effective length of database: 14,233,722
effective search space: 4867932924
effective search space used: 4867932924
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.