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Search of human proteins with 21361749
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361749 ubiquitin thioesterase 49 [Homo sapiens]
(640 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361749 ubiquitin thioesterase 49 [Homo sapiens] 1313 0.0
gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens] 762 0.0
gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens] 762 0.0
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 171 1e-42
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 110 3e-24
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 110 3e-24
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 106 8e-23
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 106 8e-23
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 106 8e-23
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens] 105 2e-22
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens] 105 2e-22
gi|41152235 ubiquitin specific protease 51 [Homo sapiens] 103 5e-22
gi|183396780 ubiquitin specific protease 20 [Homo sapiens] 90 7e-18
gi|183397136 ubiquitin specific protease 20 [Homo sapiens] 90 7e-18
gi|183397134 ubiquitin specific protease 20 [Homo sapiens] 90 7e-18
gi|45267835 ubiquitin specific protease 50 [Homo sapiens] 89 1e-17
gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo sap... 87 4e-17
gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo sapi... 87 4e-17
gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens] 87 5e-17
gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens] 87 5e-17
gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens] 85 2e-16
gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens] 84 5e-16
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens] 83 7e-16
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens] 83 7e-16
gi|122114651 ubiquitin specific peptidase 36 [Homo sapiens] 81 3e-15
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens] 78 2e-14
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens] 77 4e-14
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens] 77 4e-14
gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens] 77 4e-14
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 74 4e-13
>gi|21361749 ubiquitin thioesterase 49 [Homo sapiens]
Length = 640
Score = 1313 bits (3398), Expect = 0.0
Identities = 640/640 (100%), Positives = 640/640 (100%)
Query: 1 MDRCKHVGRLRLAQDHSILNPQKWCCLECATTESVWACLKCSHVACGRYIEDHALKHFEE 60
MDRCKHVGRLRLAQDHSILNPQKWCCLECATTESVWACLKCSHVACGRYIEDHALKHFEE
Sbjct: 1 MDRCKHVGRLRLAQDHSILNPQKWCCLECATTESVWACLKCSHVACGRYIEDHALKHFEE 60
Query: 61 TGHPLAMEVRDLYVFCYLCKDYVLNDNPEGDLKLLRSSLLAVRGQKQDTPVRRGRTLRSM 120
TGHPLAMEVRDLYVFCYLCKDYVLNDNPEGDLKLLRSSLLAVRGQKQDTPVRRGRTLRSM
Sbjct: 61 TGHPLAMEVRDLYVFCYLCKDYVLNDNPEGDLKLLRSSLLAVRGQKQDTPVRRGRTLRSM 120
Query: 121 ASGEDVVLPQRAPQGQPQMLTALWYRRQRLLARTLRLWFEKSSRGQAKLEQRRQEEALER 180
ASGEDVVLPQRAPQGQPQMLTALWYRRQRLLARTLRLWFEKSSRGQAKLEQRRQEEALER
Sbjct: 121 ASGEDVVLPQRAPQGQPQMLTALWYRRQRLLARTLRLWFEKSSRGQAKLEQRRQEEALER 180
Query: 181 KKEEARRRRREVKRRLLEELASTPPRKSARLLLHTPRDAGPAASRPAALPTSRRVPAATL 240
KKEEARRRRREVKRRLLEELASTPPRKSARLLLHTPRDAGPAASRPAALPTSRRVPAATL
Sbjct: 181 KKEEARRRRREVKRRLLEELASTPPRKSARLLLHTPRDAGPAASRPAALPTSRRVPAATL 240
Query: 241 KLRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGK 300
KLRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGK
Sbjct: 241 KLRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGK 300
Query: 301 TQLSGKPTNSSATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRE 360
TQLSGKPTNSSATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRE
Sbjct: 301 TQLSGKPTNSSATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRE 360
Query: 361 LHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGT 420
LHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGT
Sbjct: 361 LHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGT 420
Query: 421 TRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYH 480
TRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYH
Sbjct: 421 TRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYH 480
Query: 481 CIEKGFVPLNQTECLLTEMLAKFTETEALEGRIYACDQCNSKRRKSNPKPLVLSEARKQL 540
CIEKGFVPLNQTECLLTEMLAKFTETEALEGRIYACDQCNSKRRKSNPKPLVLSEARKQL
Sbjct: 481 CIEKGFVPLNQTECLLTEMLAKFTETEALEGRIYACDQCNSKRRKSNPKPLVLSEARKQL 540
Query: 541 MIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQVLTMEPYCCRDMLSSLDKETFAYDL 600
MIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQVLTMEPYCCRDMLSSLDKETFAYDL
Sbjct: 541 MIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQVLTMEPYCCRDMLSSLDKETFAYDL 600
Query: 601 SAVVMHHGKGFGSGHYTAYCYNTEGGACALLCGVGDTERG 640
SAVVMHHGKGFGSGHYTAYCYNTEGGACALLCGVGDTERG
Sbjct: 601 SAVVMHHGKGFGSGHYTAYCYNTEGGACALLCGVGDTERG 640
>gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens]
Length = 712
Score = 762 bits (1968), Expect = 0.0
Identities = 389/652 (59%), Positives = 470/652 (72%), Gaps = 34/652 (5%)
Query: 1 MDRCKHVGRLRLAQDHSILNPQKWCCLECATTESVWACLKCSHVACGRYIEDHALKHFEE 60
MD CKHVG+L+LAQDHS LNPQKW C++C TTES+WACL CSHVACGRYIE+HALKHF+E
Sbjct: 4 MDTCKHVGQLQLAQDHSSLNPQKWHCVDCNTTESIWACLSCSHVACGRYIEEHALKHFQE 63
Query: 61 TGHPLAMEVRDLYVFCYLCKDYVLNDNPEGDLKLLRSSLLAVRGQKQDTPVRRGRTLRSM 120
+ HP+A+EV ++YVFCYLC DYVLNDN GDLKLLR +L A++ Q R GR LRSM
Sbjct: 64 SSHPVALEVNEMYVFCYLCDDYVLNDNTTGDLKLLRRTLSAIKSQNYHCTTRSGRFLRSM 123
Query: 121 ASGEDVVL----PQRAPQGQPQMLTALWYRRQRLLARTLRLWFEKSSRGQAKLEQRRQEE 176
+G+D Q Q + Q+ TALW+RR+ L+ + R WFE+S G+ K E+ QE+
Sbjct: 124 GTGDDSYFLHDGAQSLLQSEDQLYTALWHRRRILMGKIFRTWFEQSPIGRKKQEEPFQEK 183
Query: 177 ALERKKEEARRRRREVKRRLLEELASTPPRKSARLL------------LHTPRDAGPAAS 224
+ K E ++RR+E++ ++ EL S PPRKS RL + P + +
Sbjct: 184 IVV--KREVKKRRQELEYQVKAELESMPPRKSLRLQGLAQSTIIEIVSVQVPAQTPASPA 241
Query: 225 RPAALPTSRRVPAATLK---LRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECF 281
+ L TS + + ++R+P + PGVTGLRNLGNTCYMNS+LQVLSHL FR+CF
Sbjct: 242 KDKVLSTSENEISQKVSDSSVKRRPIVTPGVTGLRNLGNTCYMNSVLQVLSHLLIFRQCF 301
Query: 282 LNLDPSKTEHLFPKATNGKTQLSGKPTNSSATELSLRN----DRAEACEREGFC---WNG 334
L LD ++ + KT+ P + + D C R+ +G
Sbjct: 302 LKLDLNQW---LAMTASEKTRSCKHPPVTDTVVYQMNECQEKDTGFVCSRQSSLSSGLSG 358
Query: 335 RASISRSLELIQNKEPSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRG 394
AS R +ELIQ KEP+S++ISLC ELHTLF+VMWSGKWALVSPFAMLHSVW LIPAFRG
Sbjct: 359 GASKGRKMELIQPKEPTSQYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRG 418
Query: 395 YDQQDAQEFLCELLHKVQQELESEGTTRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVT 454
Y QQDAQEFLCELL K+Q+ELE+ GT+ LIP SQRKL KQVL VVN IFHGQLLSQVT
Sbjct: 419 YAQQDAQEFLCELLDKIQRELETTGTSLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVT 478
Query: 455 CISCNYKSNTIEPFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEALEGRIY 514
C++C+ KSNTIEPFWDLSLEFPERY C K + CL+TEMLAKFTETEALEG+IY
Sbjct: 479 CLACDNKSNTIEPFWDLSLEFPERYQCSGK---DIASQPCLVTEMLAKFTETEALEGKIY 535
Query: 515 ACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFD 574
CDQCNSKRR+ + KP+VL+EA+KQLMI LPQVLRLHLKRFRWSGRN+REKIGVHV F+
Sbjct: 536 VCDQCNSKRRRFSSKPVVLTEAQKQLMICHLPQVLRLHLKRFRWSGRNNREKIGVHVGFE 595
Query: 575 QVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHHGKGFGSGHYTAYCYNTEGG 626
++L MEPYCCR+ L SL E F YDLSAVVMHHGKGFGSGHYTAYCYN+EGG
Sbjct: 596 EILNMEPYCCRETLKSLRPECFIYDLSAVVMHHGKGFGSGHYTAYCYNSEGG 647
>gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens]
Length = 712
Score = 762 bits (1968), Expect = 0.0
Identities = 389/652 (59%), Positives = 470/652 (72%), Gaps = 34/652 (5%)
Query: 1 MDRCKHVGRLRLAQDHSILNPQKWCCLECATTESVWACLKCSHVACGRYIEDHALKHFEE 60
MD CKHVG+L+LAQDHS LNPQKW C++C TTES+WACL CSHVACGRYIE+HALKHF+E
Sbjct: 4 MDTCKHVGQLQLAQDHSSLNPQKWHCVDCNTTESIWACLSCSHVACGRYIEEHALKHFQE 63
Query: 61 TGHPLAMEVRDLYVFCYLCKDYVLNDNPEGDLKLLRSSLLAVRGQKQDTPVRRGRTLRSM 120
+ HP+A+EV ++YVFCYLC DYVLNDN GDLKLLR +L A++ Q R GR LRSM
Sbjct: 64 SSHPVALEVNEMYVFCYLCDDYVLNDNTTGDLKLLRRTLSAIKSQNYHCTTRSGRFLRSM 123
Query: 121 ASGEDVVL----PQRAPQGQPQMLTALWYRRQRLLARTLRLWFEKSSRGQAKLEQRRQEE 176
+G+D Q Q + Q+ TALW+RR+ L+ + R WFE+S G+ K E+ QE+
Sbjct: 124 GTGDDSYFLHDGAQSLLQSEDQLYTALWHRRRILMGKIFRTWFEQSPIGRKKQEEPFQEK 183
Query: 177 ALERKKEEARRRRREVKRRLLEELASTPPRKSARLL------------LHTPRDAGPAAS 224
+ K E ++RR+E++ ++ EL S PPRKS RL + P + +
Sbjct: 184 IVV--KREVKKRRQELEYQVKAELESMPPRKSLRLQGLAQSTIIEIVSVQVPAQTPASPA 241
Query: 225 RPAALPTSRRVPAATLK---LRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECF 281
+ L TS + + ++R+P + PGVTGLRNLGNTCYMNS+LQVLSHL FR+CF
Sbjct: 242 KDKVLSTSENEISQKVSDSSVKRRPIVTPGVTGLRNLGNTCYMNSVLQVLSHLLIFRQCF 301
Query: 282 LNLDPSKTEHLFPKATNGKTQLSGKPTNSSATELSLRN----DRAEACEREGFC---WNG 334
L LD ++ + KT+ P + + D C R+ +G
Sbjct: 302 LKLDLNQW---LAMTASEKTRSCKHPPVTDTVVYQMNECQEKDTGFVCSRQSSLSSGLSG 358
Query: 335 RASISRSLELIQNKEPSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRG 394
AS R +ELIQ KEP+S++ISLC ELHTLF+VMWSGKWALVSPFAMLHSVW LIPAFRG
Sbjct: 359 GASKGRKMELIQPKEPTSQYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRG 418
Query: 395 YDQQDAQEFLCELLHKVQQELESEGTTRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVT 454
Y QQDAQEFLCELL K+Q+ELE+ GT+ LIP SQRKL KQVL VVN IFHGQLLSQVT
Sbjct: 419 YAQQDAQEFLCELLDKIQRELETTGTSLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVT 478
Query: 455 CISCNYKSNTIEPFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEALEGRIY 514
C++C+ KSNTIEPFWDLSLEFPERY C K + CL+TEMLAKFTETEALEG+IY
Sbjct: 479 CLACDNKSNTIEPFWDLSLEFPERYQCSGK---DIASQPCLVTEMLAKFTETEALEGKIY 535
Query: 515 ACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFD 574
CDQCNSKRR+ + KP+VL+EA+KQLMI LPQVLRLHLKRFRWSGRN+REKIGVHV F+
Sbjct: 536 VCDQCNSKRRRFSSKPVVLTEAQKQLMICHLPQVLRLHLKRFRWSGRNNREKIGVHVGFE 595
Query: 575 QVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHHGKGFGSGHYTAYCYNTEGG 626
++L MEPYCCR+ L SL E F YDLSAVVMHHGKGFGSGHYTAYCYN+EGG
Sbjct: 596 EILNMEPYCCRETLKSLRPECFIYDLSAVVMHHGKGFGSGHYTAYCYNSEGG 647
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 171 bits (434), Expect = 1e-42
Identities = 123/377 (32%), Positives = 180/377 (47%), Gaps = 70/377 (18%)
Query: 253 TGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNSSA 312
TGLRNLGNTC+MN+ILQ LS++++F C+ P+ + NGKT +G+ T +
Sbjct: 159 TGLRNLGNTCFMNAILQSLSNIEQFC-CYFKELPAV------ELRNGKT--AGRRTYHTR 209
Query: 313 TELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMWSGK 372
++ ++SL E +W G
Sbjct: 210 SQ------------------------------------GDNNVSLVEEFRKTLCALWQGS 233
Query: 373 WALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELES--EGTTRRIL----- 425
SP ++ + VW ++P FRGY QQDA EF+ LL + EL+ G +R +
Sbjct: 234 QTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENS 293
Query: 426 -IPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEK 484
+ S + VV IF G L ++V C+ C +S +PF DLSL+ P ++ ++
Sbjct: 294 TLSASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRS-KR 352
Query: 485 GFVPLNQTECLLTEMLAKFTETEAL-EGRIYACDQCNSKRRKSNPKPLVLSEARKQLMIY 543
N C L + L FT+ E L E +Y C +C K++ + K+ I
Sbjct: 353 SKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKST-----------KKFWIQ 401
Query: 544 RLPQVLRLHLKRFRWSGRNHREKIGVHVVFD-QVLTMEPYCCRDMLSSLDKETFAYDLSA 602
+LP+VL LHLKRF W+ R K+ +V F + L M+ Y S E+ YDL+A
Sbjct: 402 KLPKVLCLHLKRFHWTA-YLRNKVDTYVEFPLRGLDMKCYLLEPENSG--PESCLYDLAA 458
Query: 603 VVMHHGKGFGSGHYTAY 619
VV+HHG G GSGHYTAY
Sbjct: 459 VVVHHGSGVGSGHYTAY 475
Score = 75.1 bits (183), Expect = 2e-13
Identities = 33/96 (34%), Positives = 47/96 (48%), Gaps = 16/96 (16%)
Query: 20 NPQKWCCLECATTESVWACLKCSHVACGRYIEDHALKHFEE----------------TGH 63
+P WCC C + +S W CL CS V CGRY+ HA KH+E+ H
Sbjct: 23 SPSSWCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQVPLTNHKKSEKQDKVQH 82
Query: 64 PLAMEVRDLYVFCYLCKDYVLNDNPEGDLKLLRSSL 99
+ M+ +CY C D+V+ND G ++ +R L
Sbjct: 83 TVCMDCSSYSTYCYRCDDFVVNDTKLGLVQKVREHL 118
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 110 bits (276), Expect = 3e-24
Identities = 117/399 (29%), Positives = 152/399 (38%), Gaps = 126/399 (31%)
Query: 249 APGVTGLRNLGNTCYMNSILQVLSHLQKFRE-CFLNLDPSKTEHLFPKATNGKTQLSGKP 307
A G+ GLRNLGNTC+MNSILQ LS+ ++ R+ C L H +N T L
Sbjct: 54 AQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHH----GSNAHTAL---- 105
Query: 308 TNSSATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRV 367
+ +LIQ SS +
Sbjct: 106 ------------------------------VEEFAKLIQTIWTSSPN------------- 122
Query: 368 MWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGTTRRILIP 427
+VSP + P F GY+QQDAQEFL LL + E+ R L P
Sbjct: 123 ------DVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEV-----NRVTLRP 171
Query: 428 FSQ-----------------RKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWD 470
S RK ++ + +F GQL S +TC C Y S +PFWD
Sbjct: 172 KSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWD 231
Query: 471 LSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEALEG-RIYACDQCNSKRRKSNPK 529
LSL +R E L + + FT+ + L+G C +C ++R
Sbjct: 232 LSLPIAKR-----------GYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKR----- 275
Query: 530 PLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQVLTMEPYCCRDMLS 589
K+ I R P++L LHLKRF S R K+ V F L
Sbjct: 276 ------CIKKFSIQRFPKILVLHLKRFSES-RIRTSKLTTFVNFP-------------LR 315
Query: 590 SLDKETFA--------YDLSAVVMHHGKGFGSGHYTAYC 620
LD FA Y+L AV H G G GHYTAYC
Sbjct: 316 DLDLREFASENTNHAVYNLYAVSNHSGTTMG-GHYTAYC 353
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 110 bits (276), Expect = 3e-24
Identities = 117/399 (29%), Positives = 152/399 (38%), Gaps = 126/399 (31%)
Query: 249 APGVTGLRNLGNTCYMNSILQVLSHLQKFRE-CFLNLDPSKTEHLFPKATNGKTQLSGKP 307
A G+ GLRNLGNTC+MNSILQ LS+ ++ R+ C L H +N T L
Sbjct: 263 AQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHH----GSNAHTAL---- 314
Query: 308 TNSSATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRV 367
+ +LIQ SS +
Sbjct: 315 ------------------------------VEEFAKLIQTIWTSSPN------------- 331
Query: 368 MWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGTTRRILIP 427
+VSP + P F GY+QQDAQEFL LL + E+ R L P
Sbjct: 332 ------DVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEV-----NRVTLRP 380
Query: 428 FSQ-----------------RKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWD 470
S RK ++ + +F GQL S +TC C Y S +PFWD
Sbjct: 381 KSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWD 440
Query: 471 LSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEALEG-RIYACDQCNSKRRKSNPK 529
LSL +R E L + + FT+ + L+G C +C ++R
Sbjct: 441 LSLPIAKR-----------GYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKR----- 484
Query: 530 PLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQVLTMEPYCCRDMLS 589
K+ I R P++L LHLKRF S R K+ V F L
Sbjct: 485 ------CIKKFSIQRFPKILVLHLKRFSES-RIRTSKLTTFVNFP-------------LR 524
Query: 590 SLDKETFA--------YDLSAVVMHHGKGFGSGHYTAYC 620
LD FA Y+L AV H G G GHYTAYC
Sbjct: 525 DLDLREFASENTNHAVYNLYAVSNHSGTTMG-GHYTAYC 562
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 106 bits (264), Expect = 8e-23
Identities = 122/440 (27%), Positives = 186/440 (42%), Gaps = 75/440 (17%)
Query: 202 STPPRKSARLLLHTPRDAGPAASRPAALPTSRRVPAATLKLRRQPAMAPGVTGLRNLGN- 260
STPP A+ + RD P+ L S P T ++ + P VT N N
Sbjct: 691 STPPTHKAKPQIPAERDR-----EPSKLKRSYSSPDITQAIQEEEKRKPTVTPTVNRENK 745
Query: 261 -TCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLS--GKPTNSSATELSL 317
TCY + + LS Q NL+P +F + T L G ++ L
Sbjct: 746 PTCYPKAEISRLSASQ-----IRNLNP-----VFGGSGPALTGLRNLGNTCYMNSILQCL 795
Query: 318 RNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMWSGKWALVS 377
N A C+ I+RS L E + E + + +W+G++ +S
Sbjct: 796 CNAPHLADYFNRNCYQD--DINRSNLLGHKGE-------VAEEFGIIMKALWTGQYRYIS 846
Query: 378 PFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGTTRRI-------LIPFSQ 430
P ++ + F GY QQD+QE L L+ + ++L +R L F
Sbjct: 847 PKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKA 906
Query: 431 RKLTKQVLKVVN-----TIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKG 485
+ Q K +N +F GQ S V C++C+ KS T E F LSL
Sbjct: 907 AEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSL------------ 954
Query: 486 FVPLNQT-ECLLTEMLAKFTETEAL-EGRIYACDQCNSKRRKSNPKPLVLSEARKQLMIY 543
PL T +C L + L F++ E L + + C C ++R ++ K++ I+
Sbjct: 955 --PLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARR-----------DSLKKIEIW 1001
Query: 544 RLPQVLRLHLKRFRWSGRNHREKIGVHVVFD-QVLTMEPYCCRDMLSSLDKETFAYDLSA 602
+LP VL +HLKRF + GR ++K+ V F + L + Y ++L K Y+L +
Sbjct: 1002 KLPPVLLVHLKRFSYDGR-WKQKLQTSVDFPLENLDLSQYVIGPK-NNLKK----YNLFS 1055
Query: 603 VVMHHGKGFGSGHYTAYCYN 622
V H+G G GHYTAYC N
Sbjct: 1056 VSNHYG-GLDGGHYTAYCKN 1074
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 106 bits (264), Expect = 8e-23
Identities = 122/440 (27%), Positives = 186/440 (42%), Gaps = 75/440 (17%)
Query: 202 STPPRKSARLLLHTPRDAGPAASRPAALPTSRRVPAATLKLRRQPAMAPGVTGLRNLGN- 260
STPP A+ + RD P+ L S P T ++ + P VT N N
Sbjct: 691 STPPTHKAKPQIPAERDR-----EPSKLKRSYSSPDITQAIQEEEKRKPTVTPTVNRENK 745
Query: 261 -TCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLS--GKPTNSSATELSL 317
TCY + + LS Q NL+P +F + T L G ++ L
Sbjct: 746 PTCYPKAEISRLSASQ-----IRNLNP-----VFGGSGPALTGLRNLGNTCYMNSILQCL 795
Query: 318 RNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMWSGKWALVS 377
N A C+ I+RS L E + E + + +W+G++ +S
Sbjct: 796 CNAPHLADYFNRNCYQD--DINRSNLLGHKGE-------VAEEFGIIMKALWTGQYRYIS 846
Query: 378 PFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGTTRRI-------LIPFSQ 430
P ++ + F GY QQD+QE L L+ + ++L +R L F
Sbjct: 847 PKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKA 906
Query: 431 RKLTKQVLKVVN-----TIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKG 485
+ Q K +N +F GQ S V C++C+ KS T E F LSL
Sbjct: 907 AEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSL------------ 954
Query: 486 FVPLNQT-ECLLTEMLAKFTETEAL-EGRIYACDQCNSKRRKSNPKPLVLSEARKQLMIY 543
PL T +C L + L F++ E L + + C C ++R ++ K++ I+
Sbjct: 955 --PLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARR-----------DSLKKIEIW 1001
Query: 544 RLPQVLRLHLKRFRWSGRNHREKIGVHVVFD-QVLTMEPYCCRDMLSSLDKETFAYDLSA 602
+LP VL +HLKRF + GR ++K+ V F + L + Y ++L K Y+L +
Sbjct: 1002 KLPPVLLVHLKRFSYDGR-WKQKLQTSVDFPLENLDLSQYVIGPK-NNLKK----YNLFS 1055
Query: 603 VVMHHGKGFGSGHYTAYCYN 622
V H+G G GHYTAYC N
Sbjct: 1056 VSNHYG-GLDGGHYTAYCKN 1074
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 106 bits (264), Expect = 8e-23
Identities = 122/440 (27%), Positives = 186/440 (42%), Gaps = 75/440 (17%)
Query: 202 STPPRKSARLLLHTPRDAGPAASRPAALPTSRRVPAATLKLRRQPAMAPGVTGLRNLGN- 260
STPP A+ + RD P+ L S P T ++ + P VT N N
Sbjct: 691 STPPTHKAKPQIPAERDR-----EPSKLKRSYSSPDITQAIQEEEKRKPTVTPTVNRENK 745
Query: 261 -TCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLS--GKPTNSSATELSL 317
TCY + + LS Q NL+P +F + T L G ++ L
Sbjct: 746 PTCYPKAEISRLSASQ-----IRNLNP-----VFGGSGPALTGLRNLGNTCYMNSILQCL 795
Query: 318 RNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMWSGKWALVS 377
N A C+ I+RS L E + E + + +W+G++ +S
Sbjct: 796 CNAPHLADYFNRNCYQD--DINRSNLLGHKGE-------VAEEFGIIMKALWTGQYRYIS 846
Query: 378 PFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGTTRRI-------LIPFSQ 430
P ++ + F GY QQD+QE L L+ + ++L +R L F
Sbjct: 847 PKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKA 906
Query: 431 RKLTKQVLKVVN-----TIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKG 485
+ Q K +N +F GQ S V C++C+ KS T E F LSL
Sbjct: 907 AEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSL------------ 954
Query: 486 FVPLNQT-ECLLTEMLAKFTETEAL-EGRIYACDQCNSKRRKSNPKPLVLSEARKQLMIY 543
PL T +C L + L F++ E L + + C C ++R ++ K++ I+
Sbjct: 955 --PLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARR-----------DSLKKIEIW 1001
Query: 544 RLPQVLRLHLKRFRWSGRNHREKIGVHVVFD-QVLTMEPYCCRDMLSSLDKETFAYDLSA 602
+LP VL +HLKRF + GR ++K+ V F + L + Y ++L K Y+L +
Sbjct: 1002 KLPPVLLVHLKRFSYDGR-WKQKLQTSVDFPLENLDLSQYVIGPK-NNLKK----YNLFS 1055
Query: 603 VVMHHGKGFGSGHYTAYCYN 622
V H+G G GHYTAYC N
Sbjct: 1056 VSNHYG-GLDGGHYTAYCKN 1074
>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
Length = 438
Score = 105 bits (261), Expect = 2e-22
Identities = 111/393 (28%), Positives = 150/393 (38%), Gaps = 108/393 (27%)
Query: 251 GVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNS 310
G+ GL NLGNTC+MN I+Q L+H R+ FL+ D + E P
Sbjct: 76 GLRGLINLGNTCFMNCIVQALTHTPILRDFFLS-DRHRCEMPSP---------------- 118
Query: 311 SATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMWS 370
EL L CE SL REL +S
Sbjct: 119 ---ELCL------VCEMS---------------------------SLFREL-------YS 135
Query: 371 GKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGTTRRILIPFSQ 430
G + P+ +LH VW GY QQDA EFL L + + + + + P
Sbjct: 136 GNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAANNP--- 192
Query: 431 RKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKGFVPLN 490
+++ IF G L S VTC +C+ S TI+P WD+SL+ P F P++
Sbjct: 193 ----NHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSC----TSFWPMS 244
Query: 491 QTE-------------CLLTEMLAKFTETEAL-EGRIYACDQCNSKRRKSNPKPLVLSEA 536
LT+ L +FT E L C C S E+
Sbjct: 245 PGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQS-----------YQES 293
Query: 537 RKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQVLTMEPYCCRDMLSSLD---- 592
KQL + +LP V H KRF S + R KI ++ F L M P+ S ++
Sbjct: 294 TKQLTMNKLPVVACFHFKRFEHSAK-QRRKITTYISFPLELDMTPFMASSKESRMNGQLQ 352
Query: 593 ------KETFAYDLSAVVMHHGKGFGSGHYTAY 619
Y L AVV H G SGHYT++
Sbjct: 353 LPTNSGNNENKYSLFAVVNHQGT-LESGHYTSF 384
>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
Length = 525
Score = 105 bits (261), Expect = 2e-22
Identities = 90/296 (30%), Positives = 126/296 (42%), Gaps = 49/296 (16%)
Query: 349 EPSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELL 408
E S L E+ +LF+ +SG + P+ +LH VW+ GY+QQDA EFL L
Sbjct: 212 EMQSPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAAL 271
Query: 409 HKVQQELESEGTTRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPF 468
+ + + + ++ P +++ IF G L S VTC C+ S TI+PF
Sbjct: 272 DVLHRHCKGDDNGKKANNP-------NHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPF 324
Query: 469 WDLSLEFPERYHCIEKGFVPLN--------------QTECLLTEMLAKFTETEAL-EGRI 513
WD+SL+ P F PL+ LT+ L +FT E L
Sbjct: 325 WDISLDLPGS----STPFWPLSPGSEGNVVNGESHVSGTTTLTDCLRRFTRPEHLGSSAK 380
Query: 514 YACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVF 573
C C+S E+ KQL + +LP V HLKRF S + R KI +V F
Sbjct: 381 IKCSGCHS-----------YQESTKQLTMKKLPIVACFHLKRFEHSAK-LRRKITTYVSF 428
Query: 574 DQVLTMEPYCCRDMLSSLD----------KETFAYDLSAVVMHHGKGFGSGHYTAY 619
L M P+ S ++ Y L AVV H G SGHYT++
Sbjct: 429 PLELDMTPFMASSKESRMNGQYQQPTDSLNNDNKYSLFAVVNHQGT-LESGHYTSF 483
Score = 42.0 bits (97), Expect = 0.002
Identities = 18/33 (54%), Positives = 24/33 (72%)
Query: 251 GVTGLRNLGNTCYMNSILQVLSHLQKFRECFLN 283
G+ GL NLGNTC+MN I+Q L+H R+ FL+
Sbjct: 174 GLRGLINLGNTCFMNCIVQALTHTPLLRDFFLS 206
Score = 35.8 bits (81), Expect = 0.12
Identities = 15/53 (28%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 37 ACLKCSHVACGRYIEDHALKHFEETGHPLAMEVRDLYVFCYLCKDYVLNDNPE 89
+CL C C + + H +H + H LA+++ ++C+LC+DY+ + + E
Sbjct: 75 SCLYCVFFGC--FTKKHIHEHAKAKRHNLAIDLMYGGIYCFLCQDYIYDKDME 125
>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
Length = 711
Score = 103 bits (257), Expect = 5e-22
Identities = 85/289 (29%), Positives = 126/289 (43%), Gaps = 40/289 (13%)
Query: 351 SSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHK 410
+S + L E+ +LF M+SG P+ +LH +W GY QQDA EFL +L
Sbjct: 401 TSPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDV 460
Query: 411 VQQELESEGTTRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWD 470
+ + + + + P +++ IF G L S VTC +C+ S TI+P WD
Sbjct: 461 LHRHSKDDSGGQEANNP-------NCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWD 513
Query: 471 LSLEFPERYHCI-----EKGFVPLNQTECL-----LTEMLAKFTETEAL-EGRIYACDQC 519
+SL+ P E+ +++ + + LT+ L FT E L C+ C
Sbjct: 514 ISLDLPGSCATFDSQNPERADSTVSRDDHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSC 573
Query: 520 NSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQVLTM 579
S E+ KQL + +LP V HLKRF G+ R KI + F L M
Sbjct: 574 QS-----------YQESTKQLTMKKLPIVACFHLKRFEHVGK-QRRKINTFISFPLELDM 621
Query: 580 EPYCCRDMLSSLDK---------ETFAYDLSAVVMHHGKGFGSGHYTAY 619
P+ S + + Y L AV+ HHG SGHYT++
Sbjct: 622 TPFLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGT-LESGHYTSF 669
Score = 46.6 bits (109), Expect = 7e-05
Identities = 29/97 (29%), Positives = 45/97 (46%), Gaps = 10/97 (10%)
Query: 197 LEELASTPPRKSARLLLHTPRDAGPAA-------SRPAALPTSRRVPAATL---KLRRQP 246
+E++A K RLL T D + + T + P K R++
Sbjct: 297 IEQIAKETKEKILRLLTSTSTDVSHQQFMTSGFEDKQSTCETKEQEPKLVKPKKKRRKKS 356
Query: 247 AMAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLN 283
G+ GL NLGNTC+MN I+Q L+H+ ++ FL+
Sbjct: 357 VYTVGLRGLINLGNTCFMNCIVQALTHIPLLKDFFLS 393
Score = 45.8 bits (107), Expect = 1e-04
Identities = 24/76 (31%), Positives = 39/76 (51%), Gaps = 3/76 (3%)
Query: 26 CLECAT-TESVWACLKCSHVACGRYIEDHALKHFEETGHPLAMEVRDLYVFCYLCKDYVL 84
C C+T + +CL C C + E H KH E H LA+++ ++C++CKDYV
Sbjct: 236 CHVCSTHMNRLHSCLSCVFFGC--FTEKHIHKHAETKQHHLAVDLYHGVIYCFMCKDYVY 293
Query: 85 NDNPEGDLKLLRSSLL 100
+ + E K + +L
Sbjct: 294 DKDIEQIAKETKEKIL 309
>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 89.7 bits (221), Expect = 7e-18
Identities = 71/245 (28%), Positives = 105/245 (42%), Gaps = 58/245 (23%)
Query: 423 RILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFP-----E 477
++L S+R+ ++ V++ IF G +LS V C++C+ S T+E F DLSL P
Sbjct: 427 QVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLA 486
Query: 478 RYHCIEKGFVPLNQTEC----------------------------------LLTEMLAKF 503
+ H VP C L + LA F
Sbjct: 487 KLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAF 546
Query: 504 TETEALEG-RIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRN 562
+ L+G +Y+C++C R K + RLP++L +HLKRFR
Sbjct: 547 FAADELKGDNMYSCERCKKLRN-----------GVKYCKVLRLPEILCIHLKRFRHEVM- 594
Query: 563 HREKIGVHVVFD-QVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHHGKGFGSGHYTAYCY 621
+ KI HV F + L + P+ ++ S + YDL +V+ HHG GSGHY AYC
Sbjct: 595 YSFKINSHVSFPLEGLDLRPFLAKECTSQIT----TYDLLSVICHHGTA-GSGHYIAYCQ 649
Query: 622 NTEGG 626
N G
Sbjct: 650 NVING 654
Score = 51.2 bits (121), Expect = 3e-06
Identities = 25/85 (29%), Positives = 39/85 (45%), Gaps = 3/85 (3%)
Query: 2 DRCKHVGRLRLAQDHSILNPQKWCCLECATT-ESVWACLK--CSHVACGRYIEDHALKHF 58
D C H+ + +L K C C T ++WACL+ C +V CG DH+ H
Sbjct: 6 DLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADHSTIHA 65
Query: 59 EETGHPLAMEVRDLYVFCYLCKDYV 83
+ H L + + ++CY C+ V
Sbjct: 66 QAKKHNLTVNLTTFRLWCYACEKEV 90
Score = 50.8 bits (120), Expect = 4e-06
Identities = 44/166 (26%), Positives = 65/166 (39%), Gaps = 60/166 (36%)
Query: 251 GVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNS 310
G+TG++NLGN+CYMN+ LQ LS+ + FL G + KP
Sbjct: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFLE-------------CGGLVRTDKKP--- 186
Query: 311 SATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMWS 370
C + + +S E+ K PS
Sbjct: 187 ------------------ALCKSYQKLVS---EVWHKKRPS------------------- 206
Query: 371 GKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELE 416
V P ++ H + + P FRGY QQD QEFL L+ ++ +EL+
Sbjct: 207 ----YVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELK 248
>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 89.7 bits (221), Expect = 7e-18
Identities = 71/245 (28%), Positives = 105/245 (42%), Gaps = 58/245 (23%)
Query: 423 RILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFP-----E 477
++L S+R+ ++ V++ IF G +LS V C++C+ S T+E F DLSL P
Sbjct: 427 QVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLA 486
Query: 478 RYHCIEKGFVPLNQTEC----------------------------------LLTEMLAKF 503
+ H VP C L + LA F
Sbjct: 487 KLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAF 546
Query: 504 TETEALEG-RIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRN 562
+ L+G +Y+C++C R K + RLP++L +HLKRFR
Sbjct: 547 FAADELKGDNMYSCERCKKLRN-----------GVKYCKVLRLPEILCIHLKRFRHEVM- 594
Query: 563 HREKIGVHVVFD-QVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHHGKGFGSGHYTAYCY 621
+ KI HV F + L + P+ ++ S + YDL +V+ HHG GSGHY AYC
Sbjct: 595 YSFKINSHVSFPLEGLDLRPFLAKECTSQIT----TYDLLSVICHHGTA-GSGHYIAYCQ 649
Query: 622 NTEGG 626
N G
Sbjct: 650 NVING 654
Score = 51.2 bits (121), Expect = 3e-06
Identities = 25/85 (29%), Positives = 39/85 (45%), Gaps = 3/85 (3%)
Query: 2 DRCKHVGRLRLAQDHSILNPQKWCCLECATT-ESVWACLK--CSHVACGRYIEDHALKHF 58
D C H+ + +L K C C T ++WACL+ C +V CG DH+ H
Sbjct: 6 DLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADHSTIHA 65
Query: 59 EETGHPLAMEVRDLYVFCYLCKDYV 83
+ H L + + ++CY C+ V
Sbjct: 66 QAKKHNLTVNLTTFRLWCYACEKEV 90
Score = 50.8 bits (120), Expect = 4e-06
Identities = 44/166 (26%), Positives = 65/166 (39%), Gaps = 60/166 (36%)
Query: 251 GVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNS 310
G+TG++NLGN+CYMN+ LQ LS+ + FL G + KP
Sbjct: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFLE-------------CGGLVRTDKKP--- 186
Query: 311 SATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMWS 370
C + + +S E+ K PS
Sbjct: 187 ------------------ALCKSYQKLVS---EVWHKKRPS------------------- 206
Query: 371 GKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELE 416
V P ++ H + + P FRGY QQD QEFL L+ ++ +EL+
Sbjct: 207 ----YVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELK 248
>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 89.7 bits (221), Expect = 7e-18
Identities = 71/245 (28%), Positives = 105/245 (42%), Gaps = 58/245 (23%)
Query: 423 RILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFP-----E 477
++L S+R+ ++ V++ IF G +LS V C++C+ S T+E F DLSL P
Sbjct: 427 QVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLA 486
Query: 478 RYHCIEKGFVPLNQTEC----------------------------------LLTEMLAKF 503
+ H VP C L + LA F
Sbjct: 487 KLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAF 546
Query: 504 TETEALEG-RIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRN 562
+ L+G +Y+C++C R K + RLP++L +HLKRFR
Sbjct: 547 FAADELKGDNMYSCERCKKLRN-----------GVKYCKVLRLPEILCIHLKRFRHEVM- 594
Query: 563 HREKIGVHVVFD-QVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHHGKGFGSGHYTAYCY 621
+ KI HV F + L + P+ ++ S + YDL +V+ HHG GSGHY AYC
Sbjct: 595 YSFKINSHVSFPLEGLDLRPFLAKECTSQIT----TYDLLSVICHHGTA-GSGHYIAYCQ 649
Query: 622 NTEGG 626
N G
Sbjct: 650 NVING 654
Score = 51.2 bits (121), Expect = 3e-06
Identities = 25/85 (29%), Positives = 39/85 (45%), Gaps = 3/85 (3%)
Query: 2 DRCKHVGRLRLAQDHSILNPQKWCCLECATT-ESVWACLK--CSHVACGRYIEDHALKHF 58
D C H+ + +L K C C T ++WACL+ C +V CG DH+ H
Sbjct: 6 DLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADHSTIHA 65
Query: 59 EETGHPLAMEVRDLYVFCYLCKDYV 83
+ H L + + ++CY C+ V
Sbjct: 66 QAKKHNLTVNLTTFRLWCYACEKEV 90
Score = 50.8 bits (120), Expect = 4e-06
Identities = 44/166 (26%), Positives = 65/166 (39%), Gaps = 60/166 (36%)
Query: 251 GVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNS 310
G+TG++NLGN+CYMN+ LQ LS+ + FL G + KP
Sbjct: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFLE-------------CGGLVRTDKKP--- 186
Query: 311 SATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMWS 370
C + + +S E+ K PS
Sbjct: 187 ------------------ALCKSYQKLVS---EVWHKKRPS------------------- 206
Query: 371 GKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELE 416
V P ++ H + + P FRGY QQD QEFL L+ ++ +EL+
Sbjct: 207 ----YVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELK 248
>gi|45267835 ubiquitin specific protease 50 [Homo sapiens]
Length = 339
Score = 89.0 bits (219), Expect = 1e-17
Identities = 80/282 (28%), Positives = 120/282 (42%), Gaps = 52/282 (18%)
Query: 358 CRELHTLFRV----MWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQ 413
C E+ T F MW G VSP ++ +L PAF QQDAQEFL +L+++ +
Sbjct: 90 CSEVATAFAYLMTDMWLGDSDCVSPEIFWSALGNLYPAFTKKMQQDAQEFLICVLNELHE 149
Query: 414 ELE----------SEGTTRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSN 463
L+ +G+T+R RK ++ +F QL + C+ C +
Sbjct: 150 ALKKYHYSRRRSYEKGSTQRCC-----RKWITTETSIITQLFEEQLNYSIVCLKCEKCTY 204
Query: 464 TIEPFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEALE-GRIYACDQCNSK 522
E F SL P +Y EC L + L F + +AL C C +K
Sbjct: 205 KNEVFTVFSLPIPSKY-------------ECSLRDCLQCFFQQDALTWNNEIHCSFCETK 251
Query: 523 RRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHRE-KIGVHVVFDQVLTMEP 581
+ E + I + P+++ HLKRF G R+ + +H L + P
Sbjct: 252 Q-----------ETAVRASISKAPKIIIFHLKRFDIQGTTKRKLRTDIHYPLTN-LDLTP 299
Query: 582 YCCRDMLSSLDKETFAYDLSAVVMHHGKGFGSGHYTAYCYNT 623
Y C S+ ++ Y+L AVV H G GHYTA+C N+
Sbjct: 300 YIC-----SIFRKYPKYNLCAVVNHFG-DLDGGHYTAFCKNS 335
Score = 35.8 bits (81), Expect = 0.12
Identities = 18/32 (56%), Positives = 21/32 (65%)
Query: 251 GVTGLRNLGNTCYMNSILQVLSHLQKFRECFL 282
GVTGL NLGNTC +N+I Q L + E FL
Sbjct: 42 GVTGLWNLGNTCCVNAISQCLCSILPLVEYFL 73
>gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo
sapiens]
Length = 359
Score = 87.4 bits (215), Expect = 4e-17
Identities = 72/233 (30%), Positives = 106/233 (45%), Gaps = 39/233 (16%)
Query: 392 FRGYDQQDAQEFLCELLHKVQQELESEGTTRRILIPFSQRKLT------KQVLKVVNTIF 445
F Y QQDA EFL LL+ + L+ E + + K L V+ IF
Sbjct: 106 FDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIF 165
Query: 446 HGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTE 505
G L ++ C++C S+ E F DLS++ + +T L F+
Sbjct: 166 QGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTS---------------ITHCLRDFSN 210
Query: 506 TEAL-EGRIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHR 564
TE L + Y C+ C SK+ EA+K++ + +LP +L LHLKRF++ + HR
Sbjct: 211 TETLCSEQKYYCETCCSKQ-----------EAQKRMRVKKLPMILALHLKRFKYMEQLHR 259
Query: 565 -EKIGVHVVFDQVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHHGKGFGSGHY 616
K+ VVF L + + +LD+ YDL AVV+H G G GHY
Sbjct: 260 YTKLSYRVVFP--LELRLFNTSSDAVNLDR---MYDLVAVVVHCGSGPNRGHY 307
Score = 36.6 bits (83), Expect = 0.073
Identities = 16/26 (61%), Positives = 18/26 (69%)
Query: 254 GLRNLGNTCYMNSILQVLSHLQKFRE 279
GL N GNTCY NS+LQ L + FRE
Sbjct: 29 GLVNFGNTCYCNSVLQALYFCRPFRE 54
>gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo
sapiens]
Length = 366
Score = 87.4 bits (215), Expect = 4e-17
Identities = 72/233 (30%), Positives = 106/233 (45%), Gaps = 39/233 (16%)
Query: 392 FRGYDQQDAQEFLCELLHKVQQELESEGTTRRILIPFSQRKLT------KQVLKVVNTIF 445
F Y QQDA EFL LL+ + L+ E + + K L V+ IF
Sbjct: 113 FDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIF 172
Query: 446 HGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTE 505
G L ++ C++C S+ E F DLS++ + +T L F+
Sbjct: 173 QGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTS---------------ITHCLRDFSN 217
Query: 506 TEAL-EGRIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHR 564
TE L + Y C+ C SK+ EA+K++ + +LP +L LHLKRF++ + HR
Sbjct: 218 TETLCSEQKYYCETCCSKQ-----------EAQKRMRVKKLPMILALHLKRFKYMEQLHR 266
Query: 565 -EKIGVHVVFDQVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHHGKGFGSGHY 616
K+ VVF L + + +LD+ YDL AVV+H G G GHY
Sbjct: 267 YTKLSYRVVFP--LELRLFNTSSDAVNLDR---MYDLVAVVVHCGSGPNRGHY 314
Score = 36.6 bits (83), Expect = 0.073
Identities = 16/26 (61%), Positives = 18/26 (69%)
Query: 254 GLRNLGNTCYMNSILQVLSHLQKFRE 279
GL N GNTCY NS+LQ L + FRE
Sbjct: 36 GLVNFGNTCYCNSVLQALYFCRPFRE 61
>gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens]
Length = 485
Score = 87.0 bits (214), Expect = 5e-17
Identities = 90/378 (23%), Positives = 149/378 (39%), Gaps = 108/378 (28%)
Query: 254 GLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNSSAT 313
GL NLG TCY+N+ LQV FLNL+ + +L P S+ +
Sbjct: 90 GLTNLGATCYVNTFLQVW---------FLNLELRQALYLCP---------------STCS 125
Query: 314 ELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMWSGKW 373
+ L + E ++ EP + +C L LF ++ +
Sbjct: 126 DYMLGDGIQEE---------------------KDYEPQT----ICEHLQYLFALLQNSNR 160
Query: 374 ALVSPFAMLHSVWSLIPAFRGYD---QQDAQEFLCELLHKVQQELESEGTTRRILIPFSQ 430
+ P + ++ G D QQDAQEF + ++ L
Sbjct: 161 RYIDPSGFVKAL--------GLDTGQQQDAQEFSKLFMSLLEDTLS-------------- 198
Query: 431 RKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKGFVPLN 490
++ V +V F G+ C C +S + F++L L
Sbjct: 199 KQKNPDVRNIVQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNI--------------- 243
Query: 491 QTECLLTEMLAKFTETEALEG-RIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVL 549
Q LT+ +++F + E LEG Y C+ C SK+ A +++ + LP L
Sbjct: 244 QGHKQLTDCISEFLKEEKLEGDNRYFCENCQSKQN-----------ATRKIRLLSLPCTL 292
Query: 550 RLHLKRFRWSGRN-HREKIGVHVVFDQVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHHG 608
L L RF + + H++K+ ++ F ++L MEPY ++ Y+LSAV++H G
Sbjct: 293 NLQLMRFVFDRQTGHKKKLNTYIGFSEILDMEPYV------EHKGGSYVYELSAVLIHRG 346
Query: 609 KGFGSGHYTAYCYNTEGG 626
SGHY A+ + + G
Sbjct: 347 VSAYSGHYIAHVKDPQSG 364
>gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens]
Length = 1035
Score = 87.0 bits (214), Expect = 5e-17
Identities = 90/378 (23%), Positives = 149/378 (39%), Gaps = 108/378 (28%)
Query: 254 GLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNSSAT 313
GL NLG TCY+N+ LQV FLNL+ + +L P S+ +
Sbjct: 90 GLTNLGATCYVNTFLQVW---------FLNLELRQALYLCP---------------STCS 125
Query: 314 ELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMWSGKW 373
+ L + E ++ EP + +C L LF ++ +
Sbjct: 126 DYMLGDGIQEE---------------------KDYEPQT----ICEHLQYLFALLQNSNR 160
Query: 374 ALVSPFAMLHSVWSLIPAFRGYD---QQDAQEFLCELLHKVQQELESEGTTRRILIPFSQ 430
+ P + ++ G D QQDAQEF + ++ L
Sbjct: 161 RYIDPSGFVKAL--------GLDTGQQQDAQEFSKLFMSLLEDTLS-------------- 198
Query: 431 RKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKGFVPLN 490
++ V +V F G+ C C +S + F++L L
Sbjct: 199 KQKNPDVRNIVQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNI--------------- 243
Query: 491 QTECLLTEMLAKFTETEALEG-RIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVL 549
Q LT+ +++F + E LEG Y C+ C SK+ A +++ + LP L
Sbjct: 244 QGHKQLTDCISEFLKEEKLEGDNRYFCENCQSKQN-----------ATRKIRLLSLPCTL 292
Query: 550 RLHLKRFRWSGRN-HREKIGVHVVFDQVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHHG 608
L L RF + + H++K+ ++ F ++L MEPY ++ Y+LSAV++H G
Sbjct: 293 NLQLMRFVFDRQTGHKKKLNTYIGFSEILDMEPYV------EHKGGSYVYELSAVLIHRG 346
Query: 609 KGFGSGHYTAYCYNTEGG 626
SGHY A+ + + G
Sbjct: 347 VSAYSGHYIAHVKDPQSG 364
>gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens]
Length = 370
Score = 84.7 bits (208), Expect = 2e-16
Identities = 76/238 (31%), Positives = 112/238 (47%), Gaps = 45/238 (18%)
Query: 392 FRGYDQQDAQEFLCELLHKV----QQELESEGTTRRIL---IPFSQRKLTKQVLKVVNTI 444
F Y QQDA EFL LL+ + Q+E + E R+ I T V + I
Sbjct: 117 FDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWV-DEI 175
Query: 445 FHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERY---HCIEKGFVPLNQTECLLTEMLA 501
F G L ++ C++C S+ E F DLS++ + HC+ +GF + TE L +E
Sbjct: 176 FQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCL-RGF---SNTETLCSEYK- 230
Query: 502 KFTETEALEGRIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGR 561
Y C++C SK+ EA K++ + +LP +L LHLKRF++ +
Sbjct: 231 ------------YYCEECRSKQ-----------EAHKRMKVKKLPMILALHLKRFKYMDQ 267
Query: 562 NHR-EKIGVHVVFDQVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHHGKGFGSGHYTA 618
HR K+ VVF L + + ++ D+ YDL AVV+H G G GHY A
Sbjct: 268 LHRYTKLSYRVVFP--LELRLFNTSGDATNPDR---MYDLVAVVVHCGSGPNRGHYIA 320
Score = 37.7 bits (86), Expect = 0.033
Identities = 21/41 (51%), Positives = 23/41 (56%), Gaps = 2/41 (4%)
Query: 254 GLRNLGNTCYMNSILQVLSHLQKFRECFL--NLDPSKTEHL 292
GL N GNTCY NS+LQ L + FRE L P K E L
Sbjct: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESL 80
>gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens]
Length = 1316
Score = 83.6 bits (205), Expect = 5e-16
Identities = 100/404 (24%), Positives = 157/404 (38%), Gaps = 115/404 (28%)
Query: 228 ALPTSRRVPAATLKLRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPS 287
A P P+ + L+ Q G GL+NLGNTC+ N+ LQ L++ L+ + S
Sbjct: 87 APPQKVLFPSEKICLKWQQTHRVGA-GLQNLGNTCFANAALQCLTYTPPLANYMLSHEHS 145
Query: 288 KTEHLFPKATNGKTQLSGKPTNSSATELSLRNDRAEACEREGFCW--NGRASISRSLELI 345
KT C EGFC +A I+++L
Sbjct: 146 KT-----------------------------------CHAEGFCMMCTMQAHITQAL--- 167
Query: 346 QNKEPSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLC 405
S ++ P +++ + + FR +Q+DA EFL
Sbjct: 168 ------------------------SNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQ 203
Query: 406 ELLHKVQQELESEGTTRRILIPFSQRKLTK--QVLKVVNTIFHGQLLSQVTCISCNYKSN 463
+ +Q+ + KL + Q +V IF G L S+V C++C S+
Sbjct: 204 YTVDAMQKACLN-----------GSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSD 252
Query: 464 TIEPFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEALEG-RIYACDQCNSK 522
T +P+ D++LE K +N+ L +F + E L+G Y C +C
Sbjct: 253 TFDPYLDITLEI--------KAAQSVNKA-------LEQFVKPEQLDGENSYKCSKCKK- 296
Query: 523 RRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRF-RWSGRNHREKIGVHVVFDQVLTMEP 581
+ A K+ I+R VL L LKRF ++G KI V + + L + P
Sbjct: 297 ----------MVPASKRFTIHRSSNVLTLSLKRFANFTG----GKIAKDVKYPEYLDIRP 342
Query: 582 YCCRDMLSSLDKETFAYDLSAVVMHHGKGFGSGHYTAYCYNTEG 625
Y +S + E Y L AV++H G +GHY Y + G
Sbjct: 343 Y-----MSQPNGEPIVYVLYAVLVHTGFNCHAGHYFCYIKASNG 381
>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 83.2 bits (204), Expect = 7e-16
Identities = 79/262 (30%), Positives = 113/262 (43%), Gaps = 59/262 (22%)
Query: 389 IPAFRGYDQQDAQEFLCELLHKVQQELESEGTTRRILIPFS------------------- 429
+P+F GY QQDAQEFL L+ ++ E+ G ++
Sbjct: 291 VPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELS 350
Query: 430 ---------QRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYH 480
+R L ++ K+V+ +F GQL S + C +C Y+S T E F DLSL P
Sbjct: 351 DDDRANLMWKRYLEREDSKIVD-LFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIP---- 405
Query: 481 CIEKGFVPLNQTECLLTEMLAKFTETEALEG-RIYACDQCNSKRRKSNPKPLVLSEARKQ 539
+KGF + L + FT+ E LE CD+C K R + K+
Sbjct: 406 --KKGFA---GGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRST-----------KK 449
Query: 540 LMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFD-QVLTMEPYCCRDMLSSLDKETFAY 598
L + R P++L LHL RF + R +K V V F Q L++ + S + Y
Sbjct: 450 LTVQRFPRILVLHLNRFS-ASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPV------Y 502
Query: 599 DLSAVVMHHGKGFGSGHYTAYC 620
L A+ H G GHYTA C
Sbjct: 503 QLYALCNHSG-SVHYGHYTALC 523
Score = 41.2 bits (95), Expect = 0.003
Identities = 18/38 (47%), Positives = 25/38 (65%)
Query: 248 MAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLD 285
+ G GLRNLGNTC++N++LQ LS + R+ L D
Sbjct: 207 LGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRD 244
>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 83.2 bits (204), Expect = 7e-16
Identities = 79/262 (30%), Positives = 113/262 (43%), Gaps = 59/262 (22%)
Query: 389 IPAFRGYDQQDAQEFLCELLHKVQQELESEGTTRRILIPFS------------------- 429
+P+F GY QQDAQEFL L+ ++ E+ G ++
Sbjct: 291 VPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELS 350
Query: 430 ---------QRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYH 480
+R L ++ K+V+ +F GQL S + C +C Y+S T E F DLSL P
Sbjct: 351 DDDRANLMWKRYLEREDSKIVD-LFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIP---- 405
Query: 481 CIEKGFVPLNQTECLLTEMLAKFTETEALEG-RIYACDQCNSKRRKSNPKPLVLSEARKQ 539
+KGF + L + FT+ E LE CD+C K R + K+
Sbjct: 406 --KKGFA---GGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRST-----------KK 449
Query: 540 LMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFD-QVLTMEPYCCRDMLSSLDKETFAY 598
L + R P++L LHL RF + R +K V V F Q L++ + S + Y
Sbjct: 450 LTVQRFPRILVLHLNRFS-ASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPV------Y 502
Query: 599 DLSAVVMHHGKGFGSGHYTAYC 620
L A+ H G GHYTA C
Sbjct: 503 QLYALCNHSG-SVHYGHYTALC 523
Score = 41.2 bits (95), Expect = 0.003
Identities = 18/38 (47%), Positives = 25/38 (65%)
Query: 248 MAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLD 285
+ G GLRNLGNTC++N++LQ LS + R+ L D
Sbjct: 207 LGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRD 244
>gi|122114651 ubiquitin specific peptidase 36 [Homo sapiens]
Length = 1123
Score = 81.3 bits (199), Expect = 3e-15
Identities = 98/397 (24%), Positives = 153/397 (38%), Gaps = 111/397 (27%)
Query: 229 LPTSRRV--PAATLKLRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDP 286
+P ++V P L LR + G GL NLGNTC++N+ +Q L++ P
Sbjct: 97 VPAPQKVLFPTERLSLRWERVFRVGA-GLHNLGNTCFLNATIQCLTYT-----------P 144
Query: 287 SKTEHLFPKATNGKTQLSGKPTNSSATELSLRNDRAEACEREGFCWNGRASISRSLELIQ 346
+L K + A +C + FC L ++Q
Sbjct: 145 PLANYLLSK------------------------EHARSCHQGSFCM---------LCVMQ 171
Query: 347 NKEPSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCE 406
N H + SG + P + + + + FR +Q+DA EFL
Sbjct: 172 N--------------HIVQAFANSGN--AIKPVSFIRDLKKIARHFRFGNQEDAHEFLRY 215
Query: 407 LLHKVQQELESEGTTRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIE 466
+ +Q + L ++ Q +V+ IF G L S+V C C S+T +
Sbjct: 216 TIDAMQ---------KACLNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYD 266
Query: 467 PFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEALEG-RIYACDQCNSKRRK 525
P+ D++LE + + + L F + + L G Y C +C K
Sbjct: 267 PYLDVALEIRQAAN---------------IVRALELFVKADVLSGENAYMCAKCKKK--- 308
Query: 526 SNPKPLVLSEARKQLMIYRLPQVLRLHLKRF-RWSGRNHREKIGVHVVFDQVLTMEPYCC 584
A K+ I+R VL L LKRF +SG KI V + + L + PY
Sbjct: 309 --------VPASKRFTIHRTSNVLTLSLKRFANFSG----GKITKDVGYPEFLNIRPY-- 354
Query: 585 RDMLSSLDKETFAYDLSAVVMHHGKGFGSGHYTAYCY 621
+S + + Y L AV++H G +GHY YCY
Sbjct: 355 ---MSQNNGDPVMYGLYAVLVHSGYSCHAGHY--YCY 386
>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
Length = 952
Score = 78.2 bits (191), Expect = 2e-14
Identities = 65/239 (27%), Positives = 92/239 (38%), Gaps = 67/239 (28%)
Query: 250 PGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTN 309
PG+ GL NLGNTC+MNS +Q LS+ E FL N K Q
Sbjct: 257 PGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFL---------------NDKYQ------- 294
Query: 310 SSATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMW 369
EL+ N P + + L + MW
Sbjct: 295 ---EELNFDN------------------------------PLGMRGEIAKSYAELIKQMW 321
Query: 370 SGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL------------ES 417
SGK++ V+P A V P F GY QQD QE L LL + ++L ++
Sbjct: 322 SGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDA 381
Query: 418 EGTTRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFP 476
+G +++ + K+ ++ IFHG S + C C S T +PF L+L P
Sbjct: 382 DGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLP 440
Score = 49.7 bits (117), Expect = 8e-06
Identities = 34/92 (36%), Positives = 50/92 (54%), Gaps = 6/92 (6%)
Query: 535 EARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQVLTMEPYCCRDMLSSLDKE 594
+A K+L ++ LP VL +HLKRF +S R R+K+ V F + + L + +
Sbjct: 788 QATKKLDLWSLPPVLVVHLKRFSYS-RYMRDKLDTLVDF----PINDLDMSEFLINPNAG 842
Query: 595 TFAYDLSAVVMHHGKGFGSGHYTAYCYNTEGG 626
Y+L AV H+G G G GHYTA+ N + G
Sbjct: 843 PCRYNLIAVSNHYG-GMGGGHYTAFAKNKDDG 873
>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
Length = 822
Score = 77.4 bits (189), Expect = 4e-14
Identities = 54/155 (34%), Positives = 77/155 (49%), Gaps = 12/155 (7%)
Query: 474 EFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEAL-EGRIYACDQCNSKRRKSNPKPLV 532
E PE C N EC + L +FT E L + C+ C ++R+ + PK +
Sbjct: 610 EDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVC-TRRQCNGPKANI 668
Query: 533 LSE-------ARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQVLTMEPYCCR 585
E A+KQ++I P VL LHLKRF+ +G N R K+ H+ F ++L + P+C
Sbjct: 669 KGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLR-KVNKHIKFPEILDLAPFCTL 727
Query: 586 DMLSSLDKET-FAYDLSAVVMHHGKGFGSGHYTAY 619
+ ++ T Y L VV H G SGHYTAY
Sbjct: 728 KCKNVAEENTRVLYSLYGVVEHSGT-MRSGHYTAY 761
Score = 58.2 bits (139), Expect = 2e-08
Identities = 65/237 (27%), Positives = 91/237 (38%), Gaps = 59/237 (24%)
Query: 252 VTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNSS 311
V GL NLGNTC+ N+++Q LS RE + ++SG
Sbjct: 194 VKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEV-----------------KMSGTIVKIE 236
Query: 312 ATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMWSG 371
+L+L + LE+ N EP L + M
Sbjct: 237 PPDLAL---------------------TEPLEI--NLEPPGP---LTLAMSQFLNEMQET 270
Query: 372 KWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGTTRRILIPF--S 429
K +V+P + V F+GY QQD+QE L LL ++ E E + ++ IL F S
Sbjct: 271 KKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAE-EHQRVSKGILKAFGNS 329
Query: 430 QRKL-------------TKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSL 473
KL K + V+ IF G+L S + C C S E F DLSL
Sbjct: 330 TEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSL 386
Score = 50.1 bits (118), Expect = 6e-06
Identities = 33/101 (32%), Positives = 48/101 (47%), Gaps = 22/101 (21%)
Query: 4 CKHVGRLRLAQDH---SILNPQKWCCLECATTE--------------SVWACLKCSHVAC 46
C+H+ R L Q + +++N + C +C T SVW CLKC H C
Sbjct: 24 CRHI-RKGLEQGNLKKALVNVEWNICQDCKTDNKVKDKAEEETEEKPSVWLCLKCGHQGC 82
Query: 47 GRYI-EDHALKHF---EETGHPLAMEVRDLYVFCYLCKDYV 83
GR E HALKH+ H L + + + V+CY+C + V
Sbjct: 83 GRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEV 123
>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 77.4 bits (189), Expect = 4e-14
Identities = 54/155 (34%), Positives = 77/155 (49%), Gaps = 12/155 (7%)
Query: 474 EFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEAL-EGRIYACDQCNSKRRKSNPKPLV 532
E PE C N EC + L +FT E L + C+ C ++R+ + PK +
Sbjct: 611 EDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVC-TRRQCNGPKANI 669
Query: 533 LSE-------ARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQVLTMEPYCCR 585
E A+KQ++I P VL LHLKRF+ +G N R K+ H+ F ++L + P+C
Sbjct: 670 KGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLR-KVNKHIKFPEILDLAPFCTL 728
Query: 586 DMLSSLDKET-FAYDLSAVVMHHGKGFGSGHYTAY 619
+ ++ T Y L VV H G SGHYTAY
Sbjct: 729 KCKNVAEENTRVLYSLYGVVEHSGT-MRSGHYTAY 762
Score = 58.2 bits (139), Expect = 2e-08
Identities = 65/237 (27%), Positives = 91/237 (38%), Gaps = 59/237 (24%)
Query: 252 VTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNSS 311
V GL NLGNTC+ N+++Q LS RE + ++SG
Sbjct: 195 VKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEV-----------------KMSGTIVKIE 237
Query: 312 ATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMWSG 371
+L+L + LE+ N EP L + M
Sbjct: 238 PPDLAL---------------------TEPLEI--NLEPPGP---LTLAMSQFLNEMQET 271
Query: 372 KWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGTTRRILIPF--S 429
K +V+P + V F+GY QQD+QE L LL ++ E E + ++ IL F S
Sbjct: 272 KKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAE-EHQRVSKGILKAFGNS 330
Query: 430 QRKL-------------TKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSL 473
KL K + V+ IF G+L S + C C S E F DLSL
Sbjct: 331 TEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSL 387
Score = 50.1 bits (118), Expect = 6e-06
Identities = 33/101 (32%), Positives = 48/101 (47%), Gaps = 22/101 (21%)
Query: 4 CKHVGRLRLAQDH---SILNPQKWCCLECATTE--------------SVWACLKCSHVAC 46
C+H+ R L Q + +++N + C +C T SVW CLKC H C
Sbjct: 24 CRHI-RKGLEQGNLKKALVNVEWNICQDCKTDNKVKDKAEEETEEKPSVWLCLKCGHQGC 82
Query: 47 GRYI-EDHALKHF---EETGHPLAMEVRDLYVFCYLCKDYV 83
GR E HALKH+ H L + + + V+CY+C + V
Sbjct: 83 GRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEV 123
>gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 77.4 bits (189), Expect = 4e-14
Identities = 54/155 (34%), Positives = 77/155 (49%), Gaps = 12/155 (7%)
Query: 474 EFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEAL-EGRIYACDQCNSKRRKSNPKPLV 532
E PE C N EC + L +FT E L + C+ C ++R+ + PK +
Sbjct: 611 EDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVC-TRRQCNGPKANI 669
Query: 533 LSE-------ARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQVLTMEPYCCR 585
E A+KQ++I P VL LHLKRF+ +G N R K+ H+ F ++L + P+C
Sbjct: 670 KGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLR-KVNKHIKFPEILDLAPFCTL 728
Query: 586 DMLSSLDKET-FAYDLSAVVMHHGKGFGSGHYTAY 619
+ ++ T Y L VV H G SGHYTAY
Sbjct: 729 KCKNVAEENTRVLYSLYGVVEHSGT-MRSGHYTAY 762
Score = 58.2 bits (139), Expect = 2e-08
Identities = 65/237 (27%), Positives = 91/237 (38%), Gaps = 59/237 (24%)
Query: 252 VTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNSS 311
V GL NLGNTC+ N+++Q LS RE + ++SG
Sbjct: 195 VKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEV-----------------KMSGTIVKIE 237
Query: 312 ATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMWSG 371
+L+L + LE+ N EP L + M
Sbjct: 238 PPDLAL---------------------TEPLEI--NLEPPGP---LTLAMSQFLNEMQET 271
Query: 372 KWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGTTRRILIPF--S 429
K +V+P + V F+GY QQD+QE L LL ++ E E + ++ IL F S
Sbjct: 272 KKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAE-EHQRVSKGILKAFGNS 330
Query: 430 QRKL-------------TKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSL 473
KL K + V+ IF G+L S + C C S E F DLSL
Sbjct: 331 TEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSL 387
Score = 50.1 bits (118), Expect = 6e-06
Identities = 33/101 (32%), Positives = 48/101 (47%), Gaps = 22/101 (21%)
Query: 4 CKHVGRLRLAQDH---SILNPQKWCCLECATTE--------------SVWACLKCSHVAC 46
C+H+ R L Q + +++N + C +C T SVW CLKC H C
Sbjct: 24 CRHI-RKGLEQGNLKKALVNVEWNICQDCKTDNKVKDKAEEETEEKPSVWLCLKCGHQGC 82
Query: 47 GRYI-EDHALKHF---EETGHPLAMEVRDLYVFCYLCKDYV 83
GR E HALKH+ H L + + + V+CY+C + V
Sbjct: 83 GRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEV 123
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 73.9 bits (180), Expect = 4e-13
Identities = 69/287 (24%), Positives = 112/287 (39%), Gaps = 69/287 (24%)
Query: 220 GPAASRPAALPTSRRVPAATLKLRRQPAMAP-GVTGLRNLGNTCYMNSILQVLSHLQKFR 278
G ++ + P A + K+ RQ G TGL NLGNTC+MNS +Q +S+ Q
Sbjct: 498 GEVHNKDMSWPEEMSFTANSSKIDRQKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLT 557
Query: 279 ECFLNLDPSKTEHLFPKATNGKTQLSGKPTNSSATELSLRNDRAEACEREGFCWNGRASI 338
+ F++ HL+ + G
Sbjct: 558 QYFIS-----GRHLYELNRTNPIGMKG--------------------------------- 579
Query: 339 SRSLELIQNKEPSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQ 398
H++ C L + +WSG V+P + ++ P F G+ QQ
Sbjct: 580 ---------------HMAKC--YGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQ 622
Query: 399 DAQEFLCELLHKVQQEL------------ESEGTTRRILIPFSQRKLTKQVLKVVNTIFH 446
D+QE L LL + ++L +S+G + + ++ ++ +FH
Sbjct: 623 DSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFH 682
Query: 447 GQLLSQVTCISCNYKSNTIEPFWDLSLEFP-ERYHCIEKGFVPLNQT 492
GQL SQV C +C + S +PF LSL P + Y +E + L+ T
Sbjct: 683 GQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMDLEITVIKLDGT 729
Score = 34.7 bits (78), Expect = 0.28
Identities = 24/72 (33%), Positives = 34/72 (47%), Gaps = 17/72 (23%)
Query: 488 PLNQTECLLTEMLAKFTETEAL-EGRIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLP 546
P+N CL FT E L E +Y C +C + A K+L ++RLP
Sbjct: 1030 PINLDSCLRA-----FTSEEELGESEMYYCSKCKTH-----------CLATKKLDLWRLP 1073
Query: 547 QVLRLHLKRFRW 558
L +HLKRF++
Sbjct: 1074 PFLIIHLKRFQF 1085
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.135 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,720,928
Number of Sequences: 37866
Number of extensions: 1217135
Number of successful extensions: 8516
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 186
Number of HSP's successfully gapped in prelim test: 154
Number of HSP's that attempted gapping in prelim test: 6333
Number of HSP's gapped (non-prelim): 1631
length of query: 640
length of database: 18,247,518
effective HSP length: 109
effective length of query: 531
effective length of database: 14,120,124
effective search space: 7497785844
effective search space used: 7497785844
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.