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Search of human proteins with 11386139
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11386139 phospholipase C beta 3 [Homo sapiens]
(1234 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11386139 phospholipase C beta 3 [Homo sapiens] 2448 0.0
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 1307 0.0
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 1288 0.0
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 1006 0.0
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 740 0.0
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 738 0.0
gi|14249340 phospholipase C, delta 4 [Homo sapiens] 324 4e-88
gi|78499633 phospholipase C, eta 2 [Homo sapiens] 313 5e-85
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 291 3e-78
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 291 3e-78
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 285 1e-76
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 285 1e-76
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 285 1e-76
gi|19115964 phospholipase C delta 3 [Homo sapiens] 186 2e-46
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 184 3e-46
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 184 3e-46
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 181 4e-45
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 181 4e-45
gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 175 3e-43
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 166 2e-40
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 166 2e-40
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 160 9e-39
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 153 9e-37
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 66 2e-10
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 63 2e-09
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 60 1e-08
gi|148746195 trichohyalin [Homo sapiens] 59 3e-08
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 59 3e-08
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 59 3e-08
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 58 6e-08
>gi|11386139 phospholipase C beta 3 [Homo sapiens]
Length = 1234
Score = 2448 bits (6344), Expect = 0.0
Identities = 1234/1234 (100%), Positives = 1234/1234 (100%)
Query: 1 MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNME 60
MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNME
Sbjct: 1 MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNME 60
Query: 61 VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNF 120
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNF
Sbjct: 61 VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNF 120
Query: 121 MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS 180
MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
Sbjct: 121 MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS 180
Query: 181 ADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY 240
ADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
Sbjct: 181 ADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY 240
Query: 241 LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL 300
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
Sbjct: 241 LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL 300
Query: 301 GGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC 360
GGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
Sbjct: 301 GGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC 360
Query: 361 VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK 420
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
Sbjct: 361 VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK 420
Query: 421 QQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDS 480
QQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDS
Sbjct: 421 QQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDS 480
Query: 481 AGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGD 540
AGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGD
Sbjct: 481 AGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGD 540
Query: 541 EGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV 600
EGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
Sbjct: 541 EGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV 600
Query: 601 KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM 660
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
Sbjct: 601 KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM 660
Query: 661 PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV 720
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
Sbjct: 661 PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV 720
Query: 721 DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP 780
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
Sbjct: 721 DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP 780
Query: 781 FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLI 840
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLI
Sbjct: 781 FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLI 840
Query: 841 YTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQL 900
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQL
Sbjct: 841 YTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQL 900
Query: 901 GSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGH 960
GSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGH
Sbjct: 901 GSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGH 960
Query: 961 KALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVED 1020
KALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVED
Sbjct: 961 KALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVED 1020
Query: 1021 TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF 1080
TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF
Sbjct: 1021 TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF 1080
Query: 1081 KRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLE 1140
KRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLE
Sbjct: 1081 KRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLE 1140
Query: 1141 EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLG 1200
EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLG
Sbjct: 1141 EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLG 1200
Query: 1201 DGPLVACASNGHAPGSSGHLSGADSESQEENTQL 1234
DGPLVACASNGHAPGSSGHLSGADSESQEENTQL
Sbjct: 1201 DGPLVACASNGHAPGSSGHLSGADSESQEENTQL 1234
>gi|12083581 phosphoinositide-specific phospholipase C beta 1 isoform
a [Homo sapiens]
Length = 1216
Score = 1307 bits (3383), Expect = 0.0
Identities = 683/1269 (53%), Positives = 887/1269 (69%), Gaps = 88/1269 (6%)
Query: 1 MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNME 60
MAGAQPGVHALQL+P V ++L++G+KF+KWD++++ + LR DP GFF YWT N E
Sbjct: 1 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE 60
Query: 61 VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNF 120
+ LD+S ++D R GR+A+ PKDPK+RE+L G RLE++++TVV GPD VN LN
Sbjct: 61 TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNI-GRLEQRMITVVYGPDLVNISHLNL 119
Query: 121 MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS 180
+A Q++ AK W+ E+F LA N+LAQN SR+ FL KAYTKLKLQV +GRIP+KNI ++FS
Sbjct: 120 VAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFS 179
Query: 181 ADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY 240
AD+KRVETALE+C L +R++SI ++F+ E++ FLN LC RP+ID I E GAK KPY
Sbjct: 180 ADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPY 239
Query: 241 LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL 300
LT++Q+MDFIN KQRDPRLNE+LYPPL+ Q ++LIEKYEPN + Q+S++GF RYL
Sbjct: 240 LTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYL 299
Query: 301 GGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC 360
GEENG++ E LDL+ DM+QPLS YFINSSHNTYLTAGQLAG SSVEMYRQ LL GCRC
Sbjct: 300 SGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRC 359
Query: 361 VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK 420
VELD WKGR EEEP ITHGFTMTTE+ ++V+EAIAE AFKTSP+P++LSFENHVDS K
Sbjct: 360 VELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPK 419
Query: 421 QQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDS 480
QQAKMAEYCR IFGDALL+EPL+KYPL GVPLPSP DLM +ILVKNKK+ S+ G
Sbjct: 420 QQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEG--- 476
Query: 481 AGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGD 540
+G+K+ EQ+++ S+SS+ EPSSP G
Sbjct: 477 SGKKKLSEQASNTYSDSSSMFEPSSPGAGE------------------------------ 506
Query: 541 EGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV 600
AD E +++D+++ D KK + DEGTA SE ATEEMS LVNYI+PV
Sbjct: 507 ------------ADTESDDDDDDD----DCKKSSMDEGTAGSEAMATEEMSNLVNYIQPV 550
Query: 601 KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM 660
KF+SFE ++KRNK FEMSSFVETK +EQLTKSP+EFVEYNK QLSRIYPKGTRVDSSNYM
Sbjct: 551 KFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYM 610
Query: 661 PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV 720
PQLFWN GCQ+VALNFQT+D+AMQ+N G++EYNG+SGY LKPEFMRRPDK FDPFTE IV
Sbjct: 611 PQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIV 670
Query: 721 DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRK-YRTRTSQGNSFNPVWDEE 779
DGIVAN L VK+ISGQFLSD+KVG YVEVDMFGLPVDTRRK ++T+TSQGN+ NPVW+EE
Sbjct: 671 DGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEE 730
Query: 780 PFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALL 839
P F KVVLPTLA LRIA +EEGGKF+GHRILPV AIR GYHY+CLRNE NQPL LPA+
Sbjct: 731 PIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVF 790
Query: 840 IYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQ 899
+Y E DY+PD + D EAL NPI++V+LM+QRA+QLAAL E E + +E +
Sbjct: 791 VYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSE 850
Query: 900 LGSQPSSNPTPSPLDASPRRPPGPT-----TSPASTSLSSPGQRDDLIASILSEVAPTPL 954
S+ + P + ++ + P P + PA S+ +P + +DLI S+L+EV +
Sbjct: 851 APSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTI 910
Query: 955 DELRGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGG 1014
+EL+ K+ VKL+ + +++++L K+H +K L + + Q + R AL
Sbjct: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQND--YLRRRAALEK 968
Query: 1015 AADVEDTKEGE--------------------DEAKRYQEFQNRQVQSLLELREAQVDAEA 1054
+A + K+ E + ++ + +++Q Q LL LR+ Q +E
Sbjct: 969 SAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEK 1028
Query: 1055 QRRLEHLRQALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDK 1114
++ EH++ +Q+L +V + Q K+LKE+ E+EKKEL+K +D+KR I+EAK +DK
Sbjct: 1029 YQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDK 1088
Query: 1115 HKKEAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQ 1174
+ E E TE+ R +I E V I+RLEEAQ +R ++LV +++ QQ+ +E+PKL +L Q
Sbjct: 1089 SQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQ 1148
Query: 1175 ECQEQRARLPQEI----RRSLLGEMPE--GLGDGPLVACASNG---HAPGSSGHLSGADS 1225
E Q++ RLP EI + ++ G++ E G PL + G H SS L G D
Sbjct: 1149 EYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSSEEL-GGDI 1207
Query: 1226 ESQEENTQL 1234
+E +T L
Sbjct: 1208 PGKEFDTPL 1216
>gi|33356544 phosphoinositide-specific phospholipase C beta 1 isoform
b [Homo sapiens]
Length = 1173
Score = 1288 bits (3332), Expect = 0.0
Identities = 662/1213 (54%), Positives = 859/1213 (70%), Gaps = 81/1213 (6%)
Query: 1 MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNME 60
MAGAQPGVHALQL+P V ++L++G+KF+KWD++++ + LR DP GFF YWT N E
Sbjct: 1 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE 60
Query: 61 VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNF 120
+ LD+S ++D R GR+A+ PKDPK+RE+L G RLE++++TVV GPD VN LN
Sbjct: 61 TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNI-GRLEQRMITVVYGPDLVNISHLNL 119
Query: 121 MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS 180
+A Q++ AK W+ E+F LA N+LAQN SR+ FL KAYTKLKLQV +GRIP+KNI ++FS
Sbjct: 120 VAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFS 179
Query: 181 ADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY 240
AD+KRVETALE+C L +R++SI ++F+ E++ FLN LC RP+ID I E GAK KPY
Sbjct: 180 ADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPY 239
Query: 241 LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL 300
LT++Q+MDFIN KQRDPRLNE+LYPPL+ Q ++LIEKYEPN + Q+S++GF RYL
Sbjct: 240 LTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYL 299
Query: 301 GGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC 360
GEENG++ E LDL+ DM+QPLS YFINSSHNTYLTAGQLAG SSVEMYRQ LL GCRC
Sbjct: 300 SGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRC 359
Query: 361 VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK 420
VELD WKGR EEEP ITHGFTMTTE+ ++V+EAIAE AFKTSP+P++LSFENHVDS K
Sbjct: 360 VELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPK 419
Query: 421 QQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDS 480
QQAKMAEYCR IFGDALL+EPL+KYPL GVPLPSP DLM +ILVKNKK+ S+ G
Sbjct: 420 QQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEG--- 476
Query: 481 AGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGD 540
+G+K+ EQ+++ S+SS+ EPSSP G
Sbjct: 477 SGKKKLSEQASNTYSDSSSMFEPSSPGAGE------------------------------ 506
Query: 541 EGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV 600
AD E +++D+++ D KK + DEGTA SE ATEEMS LVNYI+PV
Sbjct: 507 ------------ADTESDDDDDDD----DCKKSSMDEGTAGSEAMATEEMSNLVNYIQPV 550
Query: 601 KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM 660
KF+SFE ++KRNK FEMSSFVETK +EQLTKSP+EFVEYNK QLSRIYPKGTRVDSSNYM
Sbjct: 551 KFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYM 610
Query: 661 PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV 720
PQLFWN GCQ+VALNFQT+D+AMQ+N G++EYNG+SGY LKPEFMRRPDK FDPFTE IV
Sbjct: 611 PQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIV 670
Query: 721 DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRK-YRTRTSQGNSFNPVWDEE 779
DGIVAN L VK+ISGQFLSD+KVG YVEVDMFGLPVDTRRK ++T+TSQGN+ NPVW+EE
Sbjct: 671 DGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEE 730
Query: 780 PFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALL 839
P F KVVLPTLA LRIA +EEGGKF+GHRILPV AIR GYHY+CLRNE NQPL LPA+
Sbjct: 731 PIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVF 790
Query: 840 IYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQ 899
+Y E DY+PD + D EAL NPI++V+LM+QRA+QLAAL E E + +E +
Sbjct: 791 VYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSE 850
Query: 900 LGSQPSSNPTPSPLDASPRRPPGPT-----TSPASTSLSSPGQRDDLIASILSEVAPTPL 954
S+ + P + ++ + P P + PA S+ +P + +DLI S+L+EV +
Sbjct: 851 APSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTI 910
Query: 955 DELRGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGG 1014
+EL+ K+ VKL+ + +++++L K+H +K L + + Q + R AL
Sbjct: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQND--YLRRRAALEK 968
Query: 1015 AADVEDTKEGE--------------------DEAKRYQEFQNRQVQSLLELREAQVDAEA 1054
+A + K+ E + ++ + +++Q Q LL LR+ Q +E
Sbjct: 969 SAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEK 1028
Query: 1055 QRRLEHLRQALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDK 1114
++ EH++ +Q+L +V + Q K+LKE+ E+EKKEL+K +D+KR I+EAK +DK
Sbjct: 1029 YQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDK 1088
Query: 1115 HKKEAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPK---LLAQ 1171
+ E E TE+ R +I E V I+RLEEAQ +R ++LV +++ QQ+ +E+PK +
Sbjct: 1089 SQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKGEGSSSF 1148
Query: 1172 LAQECQEQRARLP 1184
L++ C E + P
Sbjct: 1149 LSETCHEDPSVSP 1161
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 1006 bits (2602), Expect = 0.0
Identities = 563/1227 (45%), Positives = 762/1227 (62%), Gaps = 104/1227 (8%)
Query: 13 LEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDT 72
L PP V L +G +FIKWD+ET+ + V LRVDP G++LYWT + E++ LDI+SIRDT
Sbjct: 8 LLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDT 67
Query: 73 RTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWS 132
R G++A++PK K+R+V PD K +TVVSGPD V+ F NF++ +++ K W+
Sbjct: 68 RFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWA 127
Query: 133 EELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALES 192
E++ L + L NASR+TFL K KLK+Q+N +G+IPVKN +MF AD+KRVE AL +
Sbjct: 128 EDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSA 187
Query: 193 CGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQ 252
C L ++++I P++F +++ FL LC RP+ID+I AK KPY+T E L FINQ
Sbjct: 188 CHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQ 247
Query: 253 KQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEA 312
KQRD RLN +L+PP RP Q + LI+KYEP+ +R Q+S EG +L G EN +L +
Sbjct: 248 KQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDK 307
Query: 313 LDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPE 372
L L DMTQPL+ YFINSSHNTYLTAGQ +G SS EMYRQ LL GCRCVELD WKG+PP+
Sbjct: 308 LLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPD 367
Query: 373 EEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSI 432
EEP ITHGFTMTT++ ++ +EAIAE+AFKTSPYP+ILSFENHVDS +QQAKMAEYCR+I
Sbjct: 368 EEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTI 427
Query: 433 FGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDSAGRKRPLEQSNS 492
FGD LL EPL+K+PL PGVPLPSP+DL G+IL+KNKK GP S+ +
Sbjct: 428 FGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKN---QFSGPTSSSK--------- 475
Query: 493 ALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGDEGLNRGPYVLGP 552
++ E SSP PS+ P+ E G+EG
Sbjct: 476 ---DTGGEAEGSSP----PSA----------------PAGEGTVWAGEEG---------- 502
Query: 553 ADREDEEEDEEEEEQT------DPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFE 606
+ E+EE +EEEEE++ + KK +DEGTA EV A EEMS+LVNYI+P KF SFE
Sbjct: 503 TELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFE 562
Query: 607 AARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWN 666
+ ++N+ + +SSF E KA + L+K+ ++FV+YNK+Q+SRIYPKGTR+DSSNYMPQ+FWN
Sbjct: 563 FSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWN 622
Query: 667 VGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVAN 726
GCQ+VALNFQT+D+ MQ N VFE+NG+SGYLLK EFMRRPDK F+PF+ +D +VA
Sbjct: 623 AGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVAT 682
Query: 727 ALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQG-NSFNPVWDEEPFDFPK 785
L + VISGQFLS+R V YVEV++FGLP D +R+YRT+ S NS NPVW EEPF F K
Sbjct: 683 TLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEK 742
Query: 786 VVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEAS 845
+++P LASLR+A EEG KF+GHRI+P++A+ SGYH++CL +E+N PL +PAL I+ E
Sbjct: 743 ILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMK 802
Query: 846 DYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQLGSQPS 905
DYIP D AL NPIK S D ++ +L +G G
Sbjct: 803 DYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMG-------------------GLPEK 843
Query: 906 SNPTPSPLDASPRRPPGPTT--SPASTSLSSPGQRDDLIASILSEVAPTPLDELRGHKAL 963
P SP+ + PT+ SPA+ + G R++ + +E L+ELR K +
Sbjct: 844 PFPLASPVASQVNGALAPTSNGSPAARA----GAREEAMKE-AAEPRTASLEELRELKGV 898
Query: 964 VKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQ-----AQAEGRCRLRPG-------- 1010
VKL+ R E++LREL ++ R+ L +R LA+ G C+L PG
Sbjct: 899 VKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRS 958
Query: 1011 ----ALGGAADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQ 1066
GAA E EG D R +E ++R LL E Q + +R+ +H+ + +
Sbjct: 959 LPREESAGAAPGEG-PEGVD--GRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQIS 1015
Query: 1067 RLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSIS--EAKMRDKHKKEAELTEI 1124
++ E+ + + K LKE +E + KE++K L+ KR I DK +E EI
Sbjct: 1016 KMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREI 1075
Query: 1125 NRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKL----LAQLAQECQEQR 1180
N HI E V I+++ E ++ ++L Q L+Q+ E E + LA+ +
Sbjct: 1076 NNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLE 1135
Query: 1181 ARLPQEIRRSLLGEMPEGLGDGPLVAC 1207
A + + +R L P D P AC
Sbjct: 1136 AEVKESVRACLRTCFPSEAKDKPERAC 1162
>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
Length = 1194
Score = 740 bits (1911), Expect = 0.0
Identities = 456/1202 (37%), Positives = 676/1202 (56%), Gaps = 64/1202 (5%)
Query: 4 AQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTL-RVDPNGFFLYWTGPNMEVD 62
A+P Q E P+ L+ G+ F +++EE+ L +VD GFFL W E
Sbjct: 2 AKPYEFNWQKEVPSF---LQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQ 58
Query: 63 TLDISSIRDTRTGRYARLPKDPKIREVL-GFGGPDARLEEKLMTVVSGPDPVNTVFLNFM 121
L+ S I R+G +PKDPKI L G + LE +++ V SG D VN F +
Sbjct: 59 VLECSLINSIRSGA---IPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMV 115
Query: 122 AVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSA 181
A + K W E L + N A N S T L+K + KL N +G+IPV++I + F++
Sbjct: 116 AENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFAS 175
Query: 182 DK--KRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKP 239
K K + AL+ GL +++ I P FS E F K+C R DI+ + +I
Sbjct: 176 GKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTD 235
Query: 240 YLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRY 299
YLT++QL+ F+N+ QRDPRLNE+L+P +A +IE YEP++ ++ +S +GF RY
Sbjct: 236 YLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRY 295
Query: 300 LGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCR 359
L +EN + L+ L+L +M PL+ YFI+SSHNTYLT Q G SSVEMYRQ LL GCR
Sbjct: 296 LMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCR 355
Query: 360 CVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSA 419
CVELD W G+ ++EP ITHG M T++ +DV++AI ETAF TS YPVILSFENH S
Sbjct: 356 CVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHC-SK 414
Query: 420 KQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPD 479
QQ KM++YC +FGD LL + L+ +PL PG LPSP DL +IL+KNK R +P
Sbjct: 415 YQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNK-RLKPEV---- 469
Query: 480 SAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLG 539
K+ LE AL A E +SP D+ + + ++ P + L
Sbjct: 470 ---EKKQLE----ALRSMMEAGESASPA-NILEDDNEEEIESADQEEEAHPEFKFGNELS 521
Query: 540 DEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEP 599
+ L V + ++E+ K + N +ST++NY +P
Sbjct: 522 ADDLGHKEAVANSVKKGLVTVEDEQAWMASYKY-------VGATTNIHPYLSTMINYAQP 574
Query: 600 VKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNY 659
VKF+ F A +RN + MSSF E+ + L +EFV YNK+Q+SRIYPKG RVDSSNY
Sbjct: 575 VKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNY 634
Query: 660 MPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVI 719
MPQ+FWN GCQ+V+LN+QT D+AMQLN G FEYNG GYLLKP+FMRRPD++FDPF+E
Sbjct: 635 MPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETP 694
Query: 720 VDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDT-RRKYRTRTSQGNSFNPVWDE 778
VDG++A V+VISGQFLSD+K+G YVEVDM+GLP DT R+++RTR N NPV++E
Sbjct: 695 VDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNE 754
Query: 779 EPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPAL 838
E F F KV+LP LA LRIA +++ K +G RILP+ +++GY ++ LRNE N+PL LP +
Sbjct: 755 ESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTI 814
Query: 839 LIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQ 898
Y+PD D +AL +P K +S+ ++RA Q+ A+ G + +++
Sbjct: 815 FCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAM-GIETSDIADVPSDTSKND 873
Query: 899 QLGSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELR 958
+ G ++ +P +S R PTT+ A S + +LI + +++L+
Sbjct: 874 KKGKANTAKANVTPQSSSELR---PTTTAALASGVEAKKGIELIPQV-------RIEDLK 923
Query: 959 GHKALVKLRSRQERDLRELRKKHQRKAVTLTR----RLLDGLAQAQAEGRC--RLRPGAL 1012
KA +K +Q+++L L+KKH ++ T+ + ++ +AQ E ++ A+
Sbjct: 924 QMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAM 983
Query: 1013 ---GGAADVEDTKEGE--------DEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHL 1061
GG+ +E KE E D + +E + + E+ E + R HL
Sbjct: 984 KKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHL 1043
Query: 1062 RQALQRLREVVLDANTTQFKRLKEMNEREKKEL---QKILDRKRHNSISEAK-MRDKHKK 1117
Q + L++++++A+ Q ++LK ++RE KE+ Q + + +IS+ K +++K ++
Sbjct: 1044 SQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAER 1103
Query: 1118 EAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQ 1177
E + E+N + + + +RL Q + D+L Q + L+ L ++ +LL Q
Sbjct: 1104 ERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQ 1163
Query: 1178 EQ 1179
Q
Sbjct: 1164 TQ 1165
>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
Length = 1175
Score = 738 bits (1905), Expect = 0.0
Identities = 459/1212 (37%), Positives = 682/1212 (56%), Gaps = 70/1212 (5%)
Query: 4 AQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTL-RVDPNGFFLYWTGPNMEVD 62
A+P Q E P+ L+ G+ F +++EE+ L +VD GFFL W E
Sbjct: 2 AKPYEFNWQKEVPSF---LQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQ 58
Query: 63 TLDISSIRDTRTGRYARLPKDPKIREVL-GFGGPDARLEEKLMTVVSGPDPVNTVFLNFM 121
L+ S I R+G +PKDPKI L G + LE +++ V SG D VN F +
Sbjct: 59 VLECSLINSIRSGA---IPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMV 115
Query: 122 AVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSA 181
A + K W E L + N A N S T L+K + KL N +G+IPV++I + F++
Sbjct: 116 AENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFAS 175
Query: 182 DK--KRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKP 239
K K + AL+ GL +++ I P FS E F K+C R DI+ + +I
Sbjct: 176 GKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTD 235
Query: 240 YLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRY 299
YLT++QL+ F+N+ QRDPRLNE+L+P +A +IE YEP++ ++ +S +GF RY
Sbjct: 236 YLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRY 295
Query: 300 LGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCR 359
L +EN + L+ L+L +M PL+ YFI+SSHNTYLT Q G SSVEMYRQ LL GCR
Sbjct: 296 LMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCR 355
Query: 360 CVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSA 419
CVELD W G+ ++EP ITHG M T++ +DV++AI ETAF TS YPVILSFENH S
Sbjct: 356 CVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHC-SK 414
Query: 420 KQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPD 479
QQ KM++YC +FGD LL + L+ +PL PG LPSP DL +IL+KNK R +P
Sbjct: 415 YQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNK-RLKPEV---- 469
Query: 480 SAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLG 539
K+ LE AL A E +SP D+ + + ++ P + L
Sbjct: 470 ---EKKQLE----ALRSMMEAGESASPA-NILEDDNEEEIESADQEEEAHPEFKFGNELS 521
Query: 540 DEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEP 599
+ L V + ++E+ K + N +ST++NY +P
Sbjct: 522 ADDLGHKEAVANSVKKGLVTVEDEQAWMASYKY-------VGATTNIHPYLSTMINYAQP 574
Query: 600 VKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNY 659
VKF+ F A +RN + MSSF E+ + L +EFV YNK+Q+SRIYPKG RVDSSNY
Sbjct: 575 VKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNY 634
Query: 660 MPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVI 719
MPQ+FWN GCQ+V+LN+QT D+AMQLN G FEYNG GYLLKP+FMRRPD++FDPF+E
Sbjct: 635 MPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETP 694
Query: 720 VDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDT-RRKYRTRTSQGNSFNPVWDE 778
VDG++A V+VISGQFLSD+K+G YVEVDM+GLP DT R+++RTR N NPV++E
Sbjct: 695 VDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNE 754
Query: 779 EPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPAL 838
E F F KV+LP LA LRIA +++ K +G RILP+ +++GY ++ LRNE N+PL LP +
Sbjct: 755 ESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTI 814
Query: 839 LIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQ 898
Y+PD D +AL +P K +S+ ++RA Q+ A+ G + +++
Sbjct: 815 FCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAM-GIETSDIADVPSDTSKND 873
Query: 899 QLGSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELR 958
+ G ++ +P +S R PTT+ A S + +LI + +++L+
Sbjct: 874 KKGKANTAKANVTPQSSSELR---PTTTAALASGVEAKKGIELIPQV-------RIEDLK 923
Query: 959 GHKALVKLRSRQERDLRELRKKHQRKAVTLTR----RLLDGLAQAQAEGRC--RLRPGAL 1012
KA +K +Q+++L L+KKH ++ T+ + ++ +AQ E ++ A+
Sbjct: 924 QMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAM 983
Query: 1013 ---GGAADVEDTKEGE--------DEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHL 1061
GG+ +E KE E D + +E + + E+ E + R HL
Sbjct: 984 KKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHL 1043
Query: 1062 RQALQRLREVVLDANTTQFKRLKEMNEREKKEL---QKILDRKRHNSISEAK-MRDKHKK 1117
Q + L++++++A+ Q ++LK ++RE KE+ Q + + +IS+ K +++K ++
Sbjct: 1044 SQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAER 1103
Query: 1118 EAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQ 1177
E + E+N + + + +RL Q + D+L Q + L+ L ++ + A+E Q
Sbjct: 1104 ERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQN-----EQAKEMQ 1158
Query: 1178 EQRARLPQEIRR 1189
Q +L E+ R
Sbjct: 1159 -QMVKLEAEMDR 1169
>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
Length = 762
Score = 324 bits (830), Expect = 4e-88
Identities = 232/688 (33%), Positives = 340/688 (49%), Gaps = 97/688 (14%)
Query: 165 NQDGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRP 224
NQDG++ + + ++ VE E F +++ + E F +F L R
Sbjct: 149 NQDGKMSFQEVQRLLHL--MNVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRA 206
Query: 225 DIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQ 284
++ ++ A G+ LTL + +DF+ ++Q++ L A LI++YEP+
Sbjct: 207 EVQELFESFSADGQK-LTLLEFLDFLQEEQKERDCTSEL--------ALELIDRYEPSDS 257
Query: 285 FLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGT 344
R +SM+GF YL ++ I L + DMTQPL+ YFI SSHNTYL QL G
Sbjct: 258 GKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLVGDQLCGQ 317
Query: 345 SSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTS 404
SSVE Y +AL GCRCVE+DVW G P EP + HG T+T+ + +DV+ +A+ AF+TS
Sbjct: 318 SSVEGYIRALKRGCRCVEVDVWDG--PSGEPVVYHGHTLTSRILFKDVVATVAQYAFQTS 375
Query: 405 PYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRIL 464
YPVILS E H S +QQ MA + I G+ LL LD + P LPSP++L +IL
Sbjct: 376 DYPVILSLETHC-SWEQQQTMARHLTEILGEQLLSTTLDG--VLP-TQLPSPEELRRKIL 431
Query: 465 VKNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEE 524
VK G+K LE E+
Sbjct: 432 VK---------------GKKLTLE----------------------------------ED 442
Query: 525 VGLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEV 584
+ E+ EP+ + L + E E E +E+ Q KK S+
Sbjct: 443 LEYEEEEAEPELEESELALE--------SQFETEPEPQEQNLQNKDKKK-------KSKP 487
Query: 585 NATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQL 644
+S+LV Y++ V F+SF +++ +E+SSF ETKA + ++ EFV++N QL
Sbjct: 488 ILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQL 547
Query: 645 SRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEF 704
SR+YP G R DSSNY PQ WN GCQ+VA+N QT + M + G F NG GY+LKP+F
Sbjct: 548 SRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDF 607
Query: 705 MRRPDKSFDPFTEVIVDGIVANALRVKVISGQFL-------SDRKVGIYVEVDMFGLPVD 757
+R SF P E + A L ++VISGQ L V V+V +FG+ +D
Sbjct: 608 LRDIQSSFHP--EKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLD 665
Query: 758 TRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGK----FVGHRILPV 813
T R+ T + N FNP W + +V++P LA LR + K F+G LP
Sbjct: 666 TARQ-ETNYVENNGFNPYWGQTLCF--RVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPW 722
Query: 814 SAIRSGYHYVCLRNEANQPLCLPALLIY 841
+ ++ GY ++ L ++ L ++ +Y
Sbjct: 723 TCMQQGYRHIHLLSKDGISLRPASIFVY 750
>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
Length = 1416
Score = 313 bits (803), Expect = 5e-85
Identities = 271/899 (30%), Positives = 404/899 (44%), Gaps = 96/899 (10%)
Query: 118 LNFMAVQDDTAKVWSEELFKLAMNILAQNA------SRNTFLRKAYTKLKLQVNQDGRIP 171
L+ ++ + A+ W L L I +++ +R+ +L++ + + N DG +
Sbjct: 133 LDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEA--DKNGDGSLS 190
Query: 172 VKNILKMFSADKKRVETALESCGLKFNRSESI-RPDEFSLEIFERFLNKLCLRPDIDKIL 230
+ +L++ K V + F +++ E F F + R D+ ++
Sbjct: 191 IGEVLQLLH--KLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLM 248
Query: 231 LEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQ 290
L + K +L L F+ +Q+ + + +IE++EP + +
Sbjct: 249 LTY-SNHKDHLDAASLQRFLQVEQK--------MAGVTLESCQDIIEQFEPCPENKSKGL 299
Query: 291 MSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMY 350
+ ++GF+ Y I E + DMTQPLS YFI SSHNTYL QL S V+MY
Sbjct: 300 LGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMY 359
Query: 351 RQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVIL 410
L GCRCVE+D W G P+ EP + HG+T+T+++ +DV+E I + AF + YPVIL
Sbjct: 360 AWVLQAGCRCVEVDCWDG--PDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVIL 417
Query: 411 SFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKK- 469
S ENH S QQ KMA+Y I GD L L LPSPQ L G+ILVK KK
Sbjct: 418 SIENHC-SVIQQKKMAQYLTDILGDKL---DLSSVSSEDATTLPSPQMLKGKILVKGKKL 473
Query: 470 -------------RHRPSA----------GGPDSAGRKRPLEQSNSALSESSAATEPSSP 506
SA G S RKR + L S E
Sbjct: 474 PANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLD--SLIKESKIR 531
Query: 507 QLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGDEGLNR--GPYVLGPADREDEEE---- 560
P++ S LS ++G + + E +S D G +R G V+G R ++
Sbjct: 532 DCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLK 591
Query: 561 -----DEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCF 615
+E +E Q P + + + +S LV Y + V E + +
Sbjct: 592 KAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASS--W 649
Query: 616 EMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALN 675
++SSF ETKA + L + P +++ +N+QQLSRIYP RVDSSNY PQ FWN GCQ+VALN
Sbjct: 650 QVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALN 709
Query: 676 FQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISG 735
+Q+ +QLN F NG GY+LKP M + F+P +E + G + L +++ISG
Sbjct: 710 YQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQ--GVFNPNSEDPLPGQLKKQLVLRIISG 767
Query: 736 Q--------FLSDRK--VGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPK 785
Q L DR + +VEV++ GLPVD R+ +TR N FNP W EE F
Sbjct: 768 QQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSRE-QTRVVDDNGFNPTW-EETLVF-M 824
Query: 786 VVLPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYT 842
V +P +A +R ++ G F+G R L S++ GY +V L ++ ++
Sbjct: 825 VHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEE-----ASIFVHV 879
Query: 843 EASDYIPDDHQ--DYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQL 900
SD Q + K SL A + A S+ + T+SQ+
Sbjct: 880 AVSDISGKVKQALGLKGLFLRGPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKP 939
Query: 901 GSQP------SSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTP 953
G + + T S A PPGP +P + + PG LS P P
Sbjct: 940 GRRGFPELVLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLP 998
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 291 bits (744), Expect = 3e-78
Identities = 222/680 (32%), Positives = 323/680 (47%), Gaps = 104/680 (15%)
Query: 161 KLQVNQDGRIPVKNILKMFSADKKRVETALESCGLK-FNRSESIRPDEFSLEIFERFLNK 219
K N+D ++ K + +V+ +S K F + + D E E F
Sbjct: 151 KADKNKDNKMSFKELQNFLKELNIQVD---DSYARKIFRECDHSQTDSLEDEEIEAFYKM 207
Query: 220 LCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKY 279
L R +ID+ E G+ L+++QL+ F+ +QR+ P+ A LIE+Y
Sbjct: 208 LTQRVEIDRTFAEAAGSGET-LSVDQLVTFLQHQQREEAAG--------PALALSLIERY 258
Query: 280 EPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAG 339
EP++ + QM+ +GF YL + L + DM QPLS Y ++SSHNTYL
Sbjct: 259 EPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLED 318
Query: 340 QLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAET 399
QLAG SS E Y +AL GCRC+ELD W G P +EP I HG+T T+++ DVL AI +
Sbjct: 319 QLAGPSSTEAYIRALCKGCRCLELDCWDG--PNQEPIIYHGYTFTSKILFCDVLRAIRDY 376
Query: 400 AFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDL 459
AFK SPYPVILS ENH + +QQ MA + + +
Sbjct: 377 AFKASPYPVILSLENHC-TLEQQRVMARHLHA---------------------------I 408
Query: 460 MGRILVKNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGL 519
+G +L+ RPL+ ++L PS QL L
Sbjct: 409 LGPMLLN------------------RPLDGVTNSL--------PSPEQLKGKI------L 436
Query: 520 SNGEEVGLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGT 579
G+++G P G EG GP +EDE E + + +
Sbjct: 437 LKGKKLGGLLPP-------GGEG--------GPEATVVSDEDEAAEMEDEAVRSRVQHKP 481
Query: 580 ASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCF-EMSSFVETKAMEQLTKSPMEFVE 638
++ +E+S +V Y + V F F + + F EM+SF E +A+ L +S FV
Sbjct: 482 KEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVR 541
Query: 639 YNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGY 698
+N LSRIYP G R DSSNY P WN GCQ+VALNFQT M + G F+ NG GY
Sbjct: 542 HNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGY 601
Query: 699 LLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFL------SDRKVGIYVEVDMF 752
+LKP F+R P+ +F+P L ++VISGQ L + V V V++
Sbjct: 602 VLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIH 661
Query: 753 GLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLR--IAAFEEGGK--FVGH 808
G+ D + +T N FNP WD E F F +VV+P LA +R + ++ K F+G
Sbjct: 662 GVSRDVASR-QTAVITNNGFNPWWDTE-FAF-EVVVPDLALIRFLVEDYDASSKNDFIGQ 718
Query: 809 RILPVSAIRSGYHYVCLRNE 828
+P+++++ GY +V L ++
Sbjct: 719 STIPLNSLKQGYRHVHLMSK 738
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 291 bits (744), Expect = 3e-78
Identities = 222/680 (32%), Positives = 323/680 (47%), Gaps = 104/680 (15%)
Query: 161 KLQVNQDGRIPVKNILKMFSADKKRVETALESCGLK-FNRSESIRPDEFSLEIFERFLNK 219
K N+D ++ K + +V+ +S K F + + D E E F
Sbjct: 172 KADKNKDNKMSFKELQNFLKELNIQVD---DSYARKIFRECDHSQTDSLEDEEIEAFYKM 228
Query: 220 LCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKY 279
L R +ID+ E G+ L+++QL+ F+ +QR+ P+ A LIE+Y
Sbjct: 229 LTQRVEIDRTFAEAAGSGET-LSVDQLVTFLQHQQREEAAG--------PALALSLIERY 279
Query: 280 EPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAG 339
EP++ + QM+ +GF YL + L + DM QPLS Y ++SSHNTYL
Sbjct: 280 EPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLED 339
Query: 340 QLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAET 399
QLAG SS E Y +AL GCRC+ELD W G P +EP I HG+T T+++ DVL AI +
Sbjct: 340 QLAGPSSTEAYIRALCKGCRCLELDCWDG--PNQEPIIYHGYTFTSKILFCDVLRAIRDY 397
Query: 400 AFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDL 459
AFK SPYPVILS ENH + +QQ MA + + +
Sbjct: 398 AFKASPYPVILSLENHC-TLEQQRVMARHLHA---------------------------I 429
Query: 460 MGRILVKNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGL 519
+G +L+ RPL+ ++L PS QL L
Sbjct: 430 LGPMLLN------------------RPLDGVTNSL--------PSPEQLKGKI------L 457
Query: 520 SNGEEVGLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGT 579
G+++G P G EG GP +EDE E + + +
Sbjct: 458 LKGKKLGGLLPP-------GGEG--------GPEATVVSDEDEAAEMEDEAVRSRVQHKP 502
Query: 580 ASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCF-EMSSFVETKAMEQLTKSPMEFVE 638
++ +E+S +V Y + V F F + + F EM+SF E +A+ L +S FV
Sbjct: 503 KEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVR 562
Query: 639 YNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGY 698
+N LSRIYP G R DSSNY P WN GCQ+VALNFQT M + G F+ NG GY
Sbjct: 563 HNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGY 622
Query: 699 LLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFL------SDRKVGIYVEVDMF 752
+LKP F+R P+ +F+P L ++VISGQ L + V V V++
Sbjct: 623 VLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIH 682
Query: 753 GLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLR--IAAFEEGGK--FVGH 808
G+ D + +T N FNP WD E F F +VV+P LA +R + ++ K F+G
Sbjct: 683 GVSRDVASR-QTAVITNNGFNPWWDTE-FAF-EVVVPDLALIRFLVEDYDASSKNDFIGQ 739
Query: 809 RILPVSAIRSGYHYVCLRNE 828
+P+++++ GY +V L ++
Sbjct: 740 STIPLNSLKQGYRHVHLMSK 759
>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
Length = 1002
Score = 285 bits (730), Expect = 1e-76
Identities = 227/665 (34%), Positives = 328/665 (49%), Gaps = 71/665 (10%)
Query: 209 SLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLR 268
+ E F F + LR D+ +LL K K +LT+E+L F+ +Q+ +N V
Sbjct: 200 TFEEFCVFYKMMSLRRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT----- 250
Query: 269 PSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFI 328
+I+K+E +++ ++ + +EGF+ ++ I ++ DM QPL Y+I
Sbjct: 251 TDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYI 310
Query: 329 NSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVP 388
SSHNTYLT QL S V+MY + L GCRCVE+D W G P+ EP + HG+T+T+++
Sbjct: 311 ASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKIL 368
Query: 389 LRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLA 448
RDV+E I + AF + +PVILS ENH S +QQ K+A+Y + IFGD L + +D
Sbjct: 369 FRDVVETINKHAFVKNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVD---TG 424
Query: 449 PGVPLPSPQDLMGRILVKNKK--------RHRPSAGGPDSAGR-----KRPLEQSNSALS 495
LPSPQ L G+ILVK KK DSA K L SN
Sbjct: 425 ECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTE 484
Query: 496 E----------SSAATEPSSPQLGSPSSDSCPGLSNGEEVGL-----EKPSLEP--QKSL 538
S E P S + L GL + P ++ +KS
Sbjct: 485 HQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSH 544
Query: 539 GDEGL-NRGPYVLGPADRED--EEEDEEEEEQTDPKK--PTTDEGTASSEVNATEEMSTL 593
G + N G + R +DEE+ +Q+ K+ G + E+S L
Sbjct: 545 GRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDL 604
Query: 594 VNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTR 653
V Y V + + SF ET+A + + + +F+ YN++QL+RIYP R
Sbjct: 605 VVYTNSVAAQDIV---DDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYR 661
Query: 654 VDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFD 713
+DSSN+ P +WN GCQLVALN+Q+ MQLN F+ NG GY+LKP+ M + +F+
Sbjct: 662 IDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFN 719
Query: 714 PFTEVIVDGIVANALRVKVISGQFL--------SDRK--VGIYVEVDMFGLPVDTRRKYR 763
PF+ + L +KVISGQ L DR + +VEV++ GLPVD K +
Sbjct: 720 PFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDC-CKDQ 778
Query: 764 TRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGY 820
TR N FNPVW EE F V +P +A +R ++ G FVG R + S++ GY
Sbjct: 779 TRVVDDNGFNPVW-EETLTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGY 836
Query: 821 HYVCL 825
+V L
Sbjct: 837 RHVYL 841
>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
Length = 1693
Score = 285 bits (730), Expect = 1e-76
Identities = 227/665 (34%), Positives = 328/665 (49%), Gaps = 71/665 (10%)
Query: 209 SLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLR 268
+ E F F + LR D+ +LL K K +LT+E+L F+ +Q+ +N V
Sbjct: 200 TFEEFCVFYKMMSLRRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT----- 250
Query: 269 PSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFI 328
+I+K+E +++ ++ + +EGF+ ++ I ++ DM QPL Y+I
Sbjct: 251 TDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYI 310
Query: 329 NSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVP 388
SSHNTYLT QL S V+MY + L GCRCVE+D W G P+ EP + HG+T+T+++
Sbjct: 311 ASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKIL 368
Query: 389 LRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLA 448
RDV+E I + AF + +PVILS ENH S +QQ K+A+Y + IFGD L + +D
Sbjct: 369 FRDVVETINKHAFVKNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVD---TG 424
Query: 449 PGVPLPSPQDLMGRILVKNKK--------RHRPSAGGPDSAGR-----KRPLEQSNSALS 495
LPSPQ L G+ILVK KK DSA K L SN
Sbjct: 425 ECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTE 484
Query: 496 E----------SSAATEPSSPQLGSPSSDSCPGLSNGEEVGL-----EKPSLEP--QKSL 538
S E P S + L GL + P ++ +KS
Sbjct: 485 HQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSH 544
Query: 539 GDEGL-NRGPYVLGPADRED--EEEDEEEEEQTDPKK--PTTDEGTASSEVNATEEMSTL 593
G + N G + R +DEE+ +Q+ K+ G + E+S L
Sbjct: 545 GRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDL 604
Query: 594 VNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTR 653
V Y V + + SF ET+A + + + +F+ YN++QL+RIYP R
Sbjct: 605 VVYTNSVAAQDIV---DDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYR 661
Query: 654 VDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFD 713
+DSSN+ P +WN GCQLVALN+Q+ MQLN F+ NG GY+LKP+ M + +F+
Sbjct: 662 IDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFN 719
Query: 714 PFTEVIVDGIVANALRVKVISGQFL--------SDRK--VGIYVEVDMFGLPVDTRRKYR 763
PF+ + L +KVISGQ L DR + +VEV++ GLPVD K +
Sbjct: 720 PFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDC-CKDQ 778
Query: 764 TRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGY 820
TR N FNPVW EE F V +P +A +R ++ G FVG R + S++ GY
Sbjct: 779 TRVVDDNGFNPVW-EETLTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGY 836
Query: 821 HYVCL 825
+V L
Sbjct: 837 RHVYL 841
>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
Length = 1655
Score = 285 bits (730), Expect = 1e-76
Identities = 227/665 (34%), Positives = 328/665 (49%), Gaps = 71/665 (10%)
Query: 209 SLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLR 268
+ E F F + LR D+ +LL K K +LT+E+L F+ +Q+ +N V
Sbjct: 182 TFEEFCVFYKMMSLRRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT----- 232
Query: 269 PSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFI 328
+I+K+E +++ ++ + +EGF+ ++ I ++ DM QPL Y+I
Sbjct: 233 TDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYI 292
Query: 329 NSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVP 388
SSHNTYLT QL S V+MY + L GCRCVE+D W G P+ EP + HG+T+T+++
Sbjct: 293 ASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKIL 350
Query: 389 LRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLA 448
RDV+E I + AF + +PVILS ENH S +QQ K+A+Y + IFGD L + +D
Sbjct: 351 FRDVVETINKHAFVKNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVD---TG 406
Query: 449 PGVPLPSPQDLMGRILVKNKK--------RHRPSAGGPDSAGR-----KRPLEQSNSALS 495
LPSPQ L G+ILVK KK DSA K L SN
Sbjct: 407 ECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTE 466
Query: 496 E----------SSAATEPSSPQLGSPSSDSCPGLSNGEEVGL-----EKPSLEP--QKSL 538
S E P S + L GL + P ++ +KS
Sbjct: 467 HQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSH 526
Query: 539 GDEGL-NRGPYVLGPADRED--EEEDEEEEEQTDPKK--PTTDEGTASSEVNATEEMSTL 593
G + N G + R +DEE+ +Q+ K+ G + E+S L
Sbjct: 527 GRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDL 586
Query: 594 VNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTR 653
V Y V + + SF ET+A + + + +F+ YN++QL+RIYP R
Sbjct: 587 VVYTNSVAAQDIV---DDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYR 643
Query: 654 VDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFD 713
+DSSN+ P +WN GCQLVALN+Q+ MQLN F+ NG GY+LKP+ M + +F+
Sbjct: 644 IDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFN 701
Query: 714 PFTEVIVDGIVANALRVKVISGQFL--------SDRK--VGIYVEVDMFGLPVDTRRKYR 763
PF+ + L +KVISGQ L DR + +VEV++ GLPVD K +
Sbjct: 702 PFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDC-CKDQ 760
Query: 764 TRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGY 820
TR N FNPVW EE F V +P +A +R ++ G FVG R + S++ GY
Sbjct: 761 TRVVDDNGFNPVW-EETLTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGY 818
Query: 821 HYVCL 825
+V L
Sbjct: 819 RHVYL 823
>gi|19115964 phospholipase C delta 3 [Homo sapiens]
Length = 789
Score = 186 bits (471), Expect = 2e-46
Identities = 132/397 (33%), Positives = 201/397 (50%), Gaps = 41/397 (10%)
Query: 118 LNFMAVQDDTAKVWSEELFKLAMNILAQNASR------NTFLRKAYTKLKLQVNQDGRIP 171
L+ A + A+ W L KL + A + +++L +A + NQD ++
Sbjct: 150 LDLAAPTAEEAQRWVRGLTKLRARLDAMSQRERLDHWIHSYLHRADS------NQDSKMS 203
Query: 172 ---VKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDK 228
+K++L+M + D + L F + D E FL +L RP++++
Sbjct: 204 FKEIKSLLRMVNVDMNDMYAYL-----LFKECDHSNNDRLEGAEIEEFLRRLLKRPELEE 258
Query: 229 ILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLER 288
I + + + L+ +L++F+ + + ++A+ LI+ YE N+ +
Sbjct: 259 IFHQYSGEDR-VLSAPELLEFLEDQGEEGATL---------ARAQQLIQTYELNETAKQH 308
Query: 289 DQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVE 348
+ M+++GF YL E L + DM QPL+ YFI+SSHNTYLT Q+ G SS E
Sbjct: 309 ELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTE 368
Query: 349 MYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPV 408
Y +A GCRCVELD W+G P EP I HG T+T+++ RDV++A+ + AF SPYPV
Sbjct: 369 AYVRAFAQGCRCVELDCWEG--PGGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPV 426
Query: 409 ILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNK 468
ILS ENH +QQA MA + +I GD L+ + LD LPSP+ L GR+LVK K
Sbjct: 427 ILSLENHC-GLEQQAAMARHLCTILGDMLVTQALDS---PNPEELPSPEQLKGRVLVKGK 482
Query: 469 KRHRPSAGGPDS---AGRKRPLEQSNSALSESSAATE 502
K P+A D + R+ E E AA +
Sbjct: 483 K--LPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQ 517
Score = 155 bits (391), Expect = 3e-37
Identities = 104/301 (34%), Positives = 155/301 (51%), Gaps = 27/301 (8%)
Query: 553 ADREDEEEDEEEEEQTDPKKPTTDEGTASSEV--NATEEMSTLVNYIEPVKFKSFEAARK 610
+DRE+EEED+EEEE+ E A + + E+S L Y + ++ A
Sbjct: 496 SDREEEEEDDEEEEEEV-------EAAAQRRLAKQISPELSALAVYCHATRLRTLHPAPN 548
Query: 611 RNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQ 670
+ ++SS E KA + + ++ FV +N +QL+R+YP G R++S+NY PQ WN GCQ
Sbjct: 549 APQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQ 608
Query: 671 LVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRV 730
LVALNFQT M LNAG F NG+ GY+LKP +R+PD +FDP G L +
Sbjct: 609 LVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDP----EYPGPPRTTLSI 664
Query: 731 KVISGQFLSDRK-------VGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDF 783
+V++ Q L V V +++ G+P D R+ T N FNP W + F
Sbjct: 665 QVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQ-ETDYVLNNGFNPRWG-QTLQF 722
Query: 784 PKVVLPTLASLRIAAFE----EGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALL 839
++ P LA +R + FVG LP+S+++ GY ++ L ++ L L
Sbjct: 723 -QLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLF 781
Query: 840 I 840
I
Sbjct: 782 I 782
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 184 bits (468), Expect = 3e-46
Identities = 109/283 (38%), Positives = 160/283 (56%), Gaps = 15/283 (5%)
Query: 556 EDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCF 615
E E DE+EE + ++ + D ++ E+S LV+ + V+++ FE + K +
Sbjct: 552 EGEVTDEDEEAEMS-RRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYW 610
Query: 616 EMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALN 675
EM SF ET+A + P +FV YNK+ LSRIYP R+DSSN PQ FWN GCQ+VA+N
Sbjct: 611 EMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMN 670
Query: 676 FQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISG 735
FQT M L+ G F NG GY+L+P MR F T+ I+ G+ AL +K+ISG
Sbjct: 671 FQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISG 730
Query: 736 QFLSDRK--------VGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVV 787
Q K + YV +++ G+P D + RT+T Q NS NP++D E F+F +V
Sbjct: 731 QNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQ-RTKTVQQNSDNPIFD-ETFEF-QVN 787
Query: 788 LPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGYHYVCLRN 827
LP LA +R ++ G +F+G +P ++ GY +V LR+
Sbjct: 788 LPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRS 830
Score = 153 bits (387), Expect = 9e-37
Identities = 128/424 (30%), Positives = 202/424 (47%), Gaps = 44/424 (10%)
Query: 58 NMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVF 117
++E LDIS+I++ R G+ ++ G D E+ +++ G N
Sbjct: 152 DLEKAKLDISAIKEIRLGKNTETFRNN--------GLADQICEDCAFSILHGE---NYES 200
Query: 118 LNFMAVQDDTAKVWSEELFKLAMNILA--------QNASRNTFLRKAYTKLKLQVN---- 165
L+ +A D A +W L L QN R +L+ + + N
Sbjct: 201 LDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIML 260
Query: 166 QDGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPD 225
+D + ++K + K + L+ ++ ++ E + E E F +LC RP+
Sbjct: 261 EDTSV---ELIKQLNPTLKEAKIRLKFKEIQKSK-EKLTTRVTEEEFCEAFC-ELCTRPE 315
Query: 226 IDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQF 285
+ +L++I +K K YL LM F+ +Q + E + + I +YE +++
Sbjct: 316 VYFLLVQI-SKNKEYLDANDLMLFLEAEQGVTHITEDICLDI--------IRRYELSEEG 366
Query: 286 LERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTS 345
++ ++++GF++YL E I E ++ DMTQPLS Y+IN+SHNTYL Q G +
Sbjct: 367 RQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPA 426
Query: 346 SVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSP 405
+ Y +AL GCR VELDV G + EP + + MTT V R V+E I + AF S
Sbjct: 427 DINGYIRALKMGCRSVELDVSDG--SDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASE 484
Query: 406 YPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILV 465
YP+IL NH S QQ MA+ + +FG+ L E PL LPSP+ L I+V
Sbjct: 485 YPLILCLGNHC-SLPQQKVMAQQMKKVFGNKLYTEA----PLPSESYLPSPEKLKRMIIV 539
Query: 466 KNKK 469
K KK
Sbjct: 540 KGKK 543
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 184 bits (468), Expect = 3e-46
Identities = 109/283 (38%), Positives = 160/283 (56%), Gaps = 15/283 (5%)
Query: 556 EDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCF 615
E E DE+EE + ++ + D ++ E+S LV+ + V+++ FE + K +
Sbjct: 454 EGEVTDEDEEAEMS-RRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYW 512
Query: 616 EMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALN 675
EM SF ET+A + P +FV YNK+ LSRIYP R+DSSN PQ FWN GCQ+VA+N
Sbjct: 513 EMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMN 572
Query: 676 FQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISG 735
FQT M L+ G F NG GY+L+P MR F T+ I+ G+ AL +K+ISG
Sbjct: 573 FQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISG 632
Query: 736 QFLSDRK--------VGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVV 787
Q K + YV +++ G+P D + RT+T Q NS NP++D E F+F +V
Sbjct: 633 QNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQ-RTKTVQQNSDNPIFD-ETFEF-QVN 689
Query: 788 LPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGYHYVCLRN 827
LP LA +R ++ G +F+G +P ++ GY +V LR+
Sbjct: 690 LPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRS 732
Score = 153 bits (387), Expect = 9e-37
Identities = 128/424 (30%), Positives = 202/424 (47%), Gaps = 44/424 (10%)
Query: 58 NMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVF 117
++E LDIS+I++ R G+ ++ G D E+ +++ G N
Sbjct: 54 DLEKAKLDISAIKEIRLGKNTETFRNN--------GLADQICEDCAFSILHGE---NYES 102
Query: 118 LNFMAVQDDTAKVWSEELFKLAMNILA--------QNASRNTFLRKAYTKLKLQVN---- 165
L+ +A D A +W L L QN R +L+ + + N
Sbjct: 103 LDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIML 162
Query: 166 QDGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPD 225
+D + ++K + K + L+ ++ ++ E + E E F +LC RP+
Sbjct: 163 EDTSV---ELIKQLNPTLKEAKIRLKFKEIQKSK-EKLTTRVTEEEFCEAFC-ELCTRPE 217
Query: 226 IDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQF 285
+ +L++I +K K YL LM F+ +Q + E + + I +YE +++
Sbjct: 218 VYFLLVQI-SKNKEYLDANDLMLFLEAEQGVTHITEDICLDI--------IRRYELSEEG 268
Query: 286 LERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTS 345
++ ++++GF++YL E I E ++ DMTQPLS Y+IN+SHNTYL Q G +
Sbjct: 269 RQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPA 328
Query: 346 SVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSP 405
+ Y +AL GCR VELDV G + EP + + MTT V R V+E I + AF S
Sbjct: 329 DINGYIRALKMGCRSVELDVSDG--SDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASE 386
Query: 406 YPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILV 465
YP+IL NH S QQ MA+ + +FG+ L E PL LPSP+ L I+V
Sbjct: 387 YPLILCLGNHC-SLPQQKVMAQQMKKVFGNKLYTEA----PLPSESYLPSPEKLKRMIIV 441
Query: 466 KNKK 469
K KK
Sbjct: 442 KGKK 445
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 181 bits (459), Expect = 4e-45
Identities = 135/418 (32%), Positives = 214/418 (51%), Gaps = 44/418 (10%)
Query: 64 LDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAV 123
+DI SI++ RTG+ + + I + + E+ +V+ G N L+ +A
Sbjct: 186 IDIKSIKEVRTGKNTDIFRSNGISDQIS--------EDCAFSVIYGE---NYESLDLVAN 234
Query: 124 QDDTAKVWSEEL--------FKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNI 175
D A +W L L M +Q+ R +++ + ++++ V+ G I + N
Sbjct: 235 SADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEI--DVDNLGHITLCNA 292
Query: 176 LKMFSADKKRVETA-LESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIG 234
++ ++T+ +E + ++S+ E + E F ++LC RP+I +L++
Sbjct: 293 VQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFS 352
Query: 235 AKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSME 294
+ K +L + LM F+ +Q +NE + + +I KYEP+++ E+ +S++
Sbjct: 353 SN-KEFLDTKDLMMFLEAEQGVAHINEEI--------SLEIIHKYEPSKEGQEKGWLSID 403
Query: 295 GFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQAL 354
GF+ YL + I E + DM QPLS YFINSSHNTYL Q G S + Y +AL
Sbjct: 404 GFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRAL 463
Query: 355 LWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFEN 414
GCR VELDVW G P+ EP I G TMT+++ R V++ I + AF S YP+IL EN
Sbjct: 464 KMGCRSVELDVWDG--PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLEN 521
Query: 415 HVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVP---LPSPQDLMGRILVKNKK 469
H S KQQ M ++ + + GD L Y +P V LPSP L G+IL+K KK
Sbjct: 522 HC-SIKQQKVMVQHMKKLLGDKL-------YTTSPNVEESYLPSPDVLKGKILIKAKK 571
Score = 171 bits (432), Expect = 5e-42
Identities = 101/299 (33%), Positives = 159/299 (53%), Gaps = 14/299 (4%)
Query: 554 DREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNK 613
D DE+E E ++ + +E+S LV+ + V+FK F+ + + K
Sbjct: 582 DVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQK 641
Query: 614 CFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVA 673
+E+ SF E A + ++P +FV YNK+ L+R++P R+DSSN PQ FW GCQ+VA
Sbjct: 642 YWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVA 701
Query: 674 LNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVI 733
+NFQT + M LN G F NG GY+L+P MR F T+ V G+ L +K+I
Sbjct: 702 MNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKII 761
Query: 734 SGQFLSDRK--------VGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPK 785
SGQ K V YV V++ G+P D + RT+T N P++DE F+F +
Sbjct: 762 SGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ-RTKTVHQNGDAPIFDES-FEF-Q 818
Query: 786 VVLPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIY 841
+ LP LA +R ++ G +F+G +P +++GY +V L++ + L +L ++
Sbjct: 819 INLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVH 877
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 181 bits (459), Expect = 4e-45
Identities = 135/418 (32%), Positives = 214/418 (51%), Gaps = 44/418 (10%)
Query: 64 LDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAV 123
+DI SI++ RTG+ + + I + + E+ +V+ G N L+ +A
Sbjct: 60 IDIKSIKEVRTGKNTDIFRSNGISDQIS--------EDCAFSVIYGE---NYESLDLVAN 108
Query: 124 QDDTAKVWSEEL--------FKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNI 175
D A +W L L M +Q+ R +++ + ++++ V+ G I + N
Sbjct: 109 SADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEI--DVDNLGHITLCNA 166
Query: 176 LKMFSADKKRVETA-LESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIG 234
++ ++T+ +E + ++S+ E + E F ++LC RP+I +L++
Sbjct: 167 VQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFS 226
Query: 235 AKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSME 294
+ K +L + LM F+ +Q +NE + + +I KYEP+++ E+ +S++
Sbjct: 227 SN-KEFLDTKDLMMFLEAEQGVAHINEEI--------SLEIIHKYEPSKEGQEKGWLSID 277
Query: 295 GFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQAL 354
GF+ YL + I E + DM QPLS YFINSSHNTYL Q G S + Y +AL
Sbjct: 278 GFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRAL 337
Query: 355 LWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFEN 414
GCR VELDVW G P+ EP I G TMT+++ R V++ I + AF S YP+IL EN
Sbjct: 338 KMGCRSVELDVWDG--PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLEN 395
Query: 415 HVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVP---LPSPQDLMGRILVKNKK 469
H S KQQ M ++ + + GD L Y +P V LPSP L G+IL+K KK
Sbjct: 396 HC-SIKQQKVMVQHMKKLLGDKL-------YTTSPNVEESYLPSPDVLKGKILIKAKK 445
Score = 171 bits (432), Expect = 5e-42
Identities = 101/299 (33%), Positives = 159/299 (53%), Gaps = 14/299 (4%)
Query: 554 DREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNK 613
D DE+E E ++ + +E+S LV+ + V+FK F+ + + K
Sbjct: 456 DVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQK 515
Query: 614 CFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVA 673
+E+ SF E A + ++P +FV YNK+ L+R++P R+DSSN PQ FW GCQ+VA
Sbjct: 516 YWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVA 575
Query: 674 LNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVI 733
+NFQT + M LN G F NG GY+L+P MR F T+ V G+ L +K+I
Sbjct: 576 MNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKII 635
Query: 734 SGQFLSDRK--------VGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPK 785
SGQ K V YV V++ G+P D + RT+T N P++DE F+F +
Sbjct: 636 SGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ-RTKTVHQNGDAPIFDES-FEF-Q 692
Query: 786 VVLPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIY 841
+ LP LA +R ++ G +F+G +P +++GY +V L++ + L +L ++
Sbjct: 693 INLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVH 751
>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
Length = 608
Score = 175 bits (443), Expect = 3e-43
Identities = 101/273 (36%), Positives = 160/273 (58%), Gaps = 16/273 (5%)
Query: 197 FNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRD 256
F ++ ++ ++E F + R +I +I ++ + L L F+ Q+Q
Sbjct: 44 FKDNDRLKQGRITIEEFRAIYRIITHREEIIEIF-NTYSENRKILLASNLAQFLTQEQYA 102
Query: 257 PRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLS 316
+++ + A +I+KYEP ++ + QMS+EGF+RY+ E + E +
Sbjct: 103 AEMSKAI--------AFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVY 154
Query: 317 TDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPF 376
DMT PL+ YFI+SSHNTYL + QL G S + Y AL+ GCRC+E+D W G + EP
Sbjct: 155 QDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDG--AQNEPV 212
Query: 377 ITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDA 436
+ HG+T+T+++ + V++AI + AF TS YPV+LS ENH +A+Q+ MA+ ++ FG++
Sbjct: 213 VYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEV-MADNLQATFGES 271
Query: 437 LLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKK 469
LL + LD +P LPSP+ L +ILVKNKK
Sbjct: 272 LLSDMLDDFP----DTLPSPEALKFKILVKNKK 300
Score = 149 bits (377), Expect = 1e-35
Identities = 98/261 (37%), Positives = 147/261 (56%), Gaps = 15/261 (5%)
Query: 590 MSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYP 649
+S LV Y + KFKSF+ +R + E +S ET+A + EF+ + ++ ++RIYP
Sbjct: 349 LSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYP 408
Query: 650 KGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPD 709
K TR DSSN+ PQ FWN+GCQ+VALNFQT + M L G F NG SGY+LKP F+R
Sbjct: 409 KATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESK 468
Query: 710 KSFDPFTEVIVDGIVANALRVKVISGQFL-----SDRKVGIYVEVDMFGLPVDTRRKYRT 764
F+P I +G+ L +++ISG L S K V +++FG+P D + K +T
Sbjct: 469 SYFNPSN--IKEGMPI-TLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPND-QMKQQT 524
Query: 765 RTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEE----GGKFVGHRILPVSAIRSGY 820
R + N+F+P W+ E F F + +P LA +R + G +F+G LP+ + GY
Sbjct: 525 RVIKKNAFSPRWN-ETFTF-IIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGY 582
Query: 821 HYVCLRNEANQPLCLPALLIY 841
+ L + + L +L +Y
Sbjct: 583 RRIPLFSRMGESLEPASLFVY 603
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 166 bits (419), Expect = 2e-40
Identities = 112/302 (37%), Positives = 160/302 (52%), Gaps = 22/302 (7%)
Query: 557 DEEEDEEEEEQTDPKKPTTDEGTASSEVNATE----------EMSTLVNYIEPVKFKSFE 606
D D +EE Q KK TA + + + E+S LV Y PV F +
Sbjct: 910 DVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEK 969
Query: 607 AARKRNKCFEMSSFVETKAMEQLTKSP-MEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFW 665
+R +MSSF ETKA + + K+ +F++YN+ QLSRIYPKG R+DSSNY P W
Sbjct: 970 IGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMW 1029
Query: 666 NVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVA 725
G QLVALNFQT D MQ+N +F GY+L+P MR D++FDPF + + G+
Sbjct: 1030 ICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR--DEAFDPFDKSSLRGLEP 1087
Query: 726 NALRVKVISGQFLSDRKVGI---YVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFD 782
A+ ++V+ + L GI +VE+++ G D+ K +T N NPVW +PF
Sbjct: 1088 CAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDS-TKQKTEFVVDNGLNPVWPAKPFH 1146
Query: 783 FPKVVLPTLASLRIAAFEE----GGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPAL 838
F ++ P A LR +EE F+ PV +++GY V L+N ++ L L +L
Sbjct: 1147 F-QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASL 1205
Query: 839 LI 840
LI
Sbjct: 1206 LI 1207
Score = 145 bits (365), Expect = 3e-34
Identities = 127/426 (29%), Positives = 195/426 (45%), Gaps = 38/426 (8%)
Query: 61 VDTLDISSIRDTRTGR-YARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLN 119
+D +I IR +T R + R +DP R PD + ++ G + L+
Sbjct: 73 IDIREIKEIRPGKTSRDFDRYQEDPAFR-------PD---QSHCFVILYGME-FRLKTLS 121
Query: 120 FMAVQDDTAKVWSEELFKLAMNILAQNASRNT--FLRKAYTKLKLQVNQDGRIPVKNILK 177
A +D +W + L L + L +LRK + + N++ RI K++
Sbjct: 122 LQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQF--YSVDRNREDRISAKDLKN 179
Query: 178 MFSADKKRVETAL---ESCGLKFNRSESIRPDEFSLEIFERFL---NKLCLRPDIDKILL 231
M S RV E RS I +F+ +++ + K P ++ L
Sbjct: 180 MLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFA-QLYRSLMYSAQKTMDLPFLEASTL 238
Query: 232 EIGAKGKPY-LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQ 290
G + + ++L + F+ Q + L+ R ++ + +E
Sbjct: 239 RAGERPELCRVSLPEFQQFLLDYQGE------LWAVDRLQVQEFMLSFLRDPLREIEEPY 292
Query: 291 MSMEGFSRYLGGEENGILPLEALDLSTD-MTQPLSAYFINSSHNTYLTAGQLAGTSSVEM 349
++ F +L +EN + + + D M PLS Y+I+SSHNTYLT Q + SS+E
Sbjct: 293 FFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEA 352
Query: 350 YRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVI 409
Y + L GCRC+ELD W G P+ P I HG T+TT++ DVL I E AF S YPVI
Sbjct: 353 YARCLRMGCRCIELDCWDG--PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVI 410
Query: 410 LSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKK 469
LS E+H S QQ MA+Y + + GD LL +P++ LPSP L +IL+K+KK
Sbjct: 411 LSIEDHC-SIAQQRNMAQYFKKVLGDTLLTKPVE----ISADGLPSPNQLKRKILIKHKK 465
Query: 470 RHRPSA 475
SA
Sbjct: 466 LAEGSA 471
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 166 bits (419), Expect = 2e-40
Identities = 112/302 (37%), Positives = 160/302 (52%), Gaps = 22/302 (7%)
Query: 557 DEEEDEEEEEQTDPKKPTTDEGTASSEVNATE----------EMSTLVNYIEPVKFKSFE 606
D D +EE Q KK TA + + + E+S LV Y PV F +
Sbjct: 910 DVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEK 969
Query: 607 AARKRNKCFEMSSFVETKAMEQLTKSP-MEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFW 665
+R +MSSF ETKA + + K+ +F++YN+ QLSRIYPKG R+DSSNY P W
Sbjct: 970 IGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMW 1029
Query: 666 NVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVA 725
G QLVALNFQT D MQ+N +F GY+L+P MR D++FDPF + + G+
Sbjct: 1030 ICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR--DEAFDPFDKSSLRGLEP 1087
Query: 726 NALRVKVISGQFLSDRKVGI---YVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFD 782
A+ ++V+ + L GI +VE+++ G D+ K +T N NPVW +PF
Sbjct: 1088 CAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDS-TKQKTEFVVDNGLNPVWPAKPFH 1146
Query: 783 FPKVVLPTLASLRIAAFEE----GGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPAL 838
F ++ P A LR +EE F+ PV +++GY V L+N ++ L L +L
Sbjct: 1147 F-QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASL 1205
Query: 839 LI 840
LI
Sbjct: 1206 LI 1207
Score = 145 bits (365), Expect = 3e-34
Identities = 127/426 (29%), Positives = 195/426 (45%), Gaps = 38/426 (8%)
Query: 61 VDTLDISSIRDTRTGR-YARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLN 119
+D +I IR +T R + R +DP R PD + ++ G + L+
Sbjct: 73 IDIREIKEIRPGKTSRDFDRYQEDPAFR-------PD---QSHCFVILYGME-FRLKTLS 121
Query: 120 FMAVQDDTAKVWSEELFKLAMNILAQNASRNT--FLRKAYTKLKLQVNQDGRIPVKNILK 177
A +D +W + L L + L +LRK + + N++ RI K++
Sbjct: 122 LQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQF--YSVDRNREDRISAKDLKN 179
Query: 178 MFSADKKRVETAL---ESCGLKFNRSESIRPDEFSLEIFERFL---NKLCLRPDIDKILL 231
M S RV E RS I +F+ +++ + K P ++ L
Sbjct: 180 MLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFA-QLYRSLMYSAQKTMDLPFLEASTL 238
Query: 232 EIGAKGKPY-LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQ 290
G + + ++L + F+ Q + L+ R ++ + +E
Sbjct: 239 RAGERPELCRVSLPEFQQFLLDYQGE------LWAVDRLQVQEFMLSFLRDPLREIEEPY 292
Query: 291 MSMEGFSRYLGGEENGILPLEALDLSTD-MTQPLSAYFINSSHNTYLTAGQLAGTSSVEM 349
++ F +L +EN + + + D M PLS Y+I+SSHNTYLT Q + SS+E
Sbjct: 293 FFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEA 352
Query: 350 YRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVI 409
Y + L GCRC+ELD W G P+ P I HG T+TT++ DVL I E AF S YPVI
Sbjct: 353 YARCLRMGCRCIELDCWDG--PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVI 410
Query: 410 LSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKK 469
LS E+H S QQ MA+Y + + GD LL +P++ LPSP L +IL+K+KK
Sbjct: 411 LSIEDHC-SIAQQRNMAQYFKKVLGDTLLTKPVE----ISADGLPSPNQLKRKILIKHKK 465
Query: 470 RHRPSA 475
SA
Sbjct: 466 LAEGSA 471
>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
Length = 2302
Score = 160 bits (404), Expect = 9e-39
Identities = 89/196 (45%), Positives = 124/196 (63%), Gaps = 4/196 (2%)
Query: 275 LIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPL-EALDLSTDMTQPLSAYFINSSHN 333
+I+K+EP+ + MS EGF+R+L +EN E+ + ++ PLS Y+I SSHN
Sbjct: 1349 IIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLSYYYIESSHN 1408
Query: 334 TYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVL 393
TYLT QL G SSVE+Y Q LL GCR VELD W G + P I HG T+TT++P ++V+
Sbjct: 1409 TYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDG--DDGMPIIYHGHTLTTKIPFKEVV 1466
Query: 394 EAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPL 453
EAI +AF S P+I+S ENH S QQ KMAE +++FG+ L+ + L + + L
Sbjct: 1467 EAIDRSAFINSDLPIIISIENHC-SLPQQRKMAEIFKTVFGEKLVTKFLFETDFSDDPML 1525
Query: 454 PSPQDLMGRILVKNKK 469
PSP L ++L+KNKK
Sbjct: 1526 PSPDQLRKKVLLKNKK 1541
Score = 130 bits (328), Expect = 6e-30
Identities = 91/276 (32%), Positives = 141/276 (51%), Gaps = 11/276 (3%)
Query: 604 SFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQL 663
S A + KC+ +SS E A + + ++ QL R YP TR+DSSN P +
Sbjct: 1744 SLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLM 1803
Query: 664 FWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPD----KSFDPFTEVI 719
FW G QLVALN+QT D+ + LNA +FE NG GY+LKP + + + F P E
Sbjct: 1804 FWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPL-ERD 1862
Query: 720 VDGIVANALRVKVISGQFL--SDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWD 777
+D + + ++SGQ + S+ +EVD+ G+P+D+ +RT+ N+ NP+W+
Sbjct: 1863 LDSMDPAVYSLTIVSGQNVCPSNSMGSPCIEVDVLGMPLDSCH-FRTKPIHRNTLNPMWN 1921
Query: 778 EEPFDFPKVVLPTLASLRIAAFEEGGKFV-GHRILPVSAIRSGYHYVCLRNEANQPLCLP 836
E+ F F V L LR A E V RI+P+ A++ GY ++ LRN N+ L +
Sbjct: 1922 EQ-FLF-HVHFEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEIS 1979
Query: 837 ALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQR 872
+L I + + + A ++ N + L R
Sbjct: 1980 SLFINSRRMEENSSGNTMSASSMFNTEERKCLQTHR 2015
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 153 bits (387), Expect = 9e-37
Identities = 101/278 (36%), Positives = 152/278 (54%), Gaps = 18/278 (6%)
Query: 589 EMSTLVNYIEPVKFKSFEAARKRNKCF-EMSSFVETKAMEQLTKSPMEFVEYNKQQLSRI 647
E+S LV Y +P S N F E+ SFVETKA + + P++ ++YN++ L+R+
Sbjct: 929 ELSDLVVYCKPT---SKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRV 985
Query: 648 YPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRR 707
YPKG RVDSSNY P W G Q+VALNFQT D MQ+N +F NGR+GY+L+PE MR
Sbjct: 986 YPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR- 1044
Query: 708 PDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGI---YVEVDMFGLPVDTRRKYRT 764
+ +DP I+ L VKV+ + L I +VEV++ G D K++T
Sbjct: 1045 -TEKYDPMPPESQRKILM-TLTVKVLGARHLPKLGRSIACPFVEVEICGAEYD-NNKFKT 1101
Query: 765 RTSQGNSFNPVW--DEEPFDFPKVVLPTLASLRIAAFEE----GGKFVGHRILPVSAIRS 818
N +P+W +E F ++ P LA LR +EE F+ H P+ A++S
Sbjct: 1102 TVVNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKS 1160
Query: 819 GYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYA 856
G+ V L+N ++ + L +LL++ E + + + Y+
Sbjct: 1161 GFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYS 1198
Score = 148 bits (373), Expect = 4e-35
Identities = 138/430 (32%), Positives = 202/430 (46%), Gaps = 61/430 (14%)
Query: 64 LDISSIRDTRTGRYAR-LPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMA 122
LDI I++ R G+ ++ + +R+ E+ T++ G V + L+ A
Sbjct: 65 LDIMEIKEIRPGKNSKDFERAKAVRQK----------EDCCFTILYGTQFVLST-LSLAA 113
Query: 123 VQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGR--IPVKNILKMFS 180
+ A W L L A NAS T + K V+Q R I ++ + +
Sbjct: 114 DSKEDAVNWLSGLKILHQE--AMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILP 171
Query: 181 ADKKRVETALESCGLKFNRSESIR----PDEFSLEIFERFLNKLCLRPDI--------DK 228
+V +A KF + + + DE S E F F KL D
Sbjct: 172 LINFKVSSA------KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDS 225
Query: 229 ILLEIGAKGKPYLTLEQLMDF----INQKQRD--PRLNEVLYPPLRPSQARLLIEKY-EP 281
+ +G +P + L DF I+++Q LN+V R + + + E
Sbjct: 226 SVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKV-----RERMTKFIDDTMRET 280
Query: 282 NQQFLERDQMSMEGFSRYLGGEENGILP--LEALDLSTDMTQPLSAYFINSSHNTYLTAG 339
+ FL D+ F YL EN I +A+D+ DM PLS Y+I+SSHNTYLT
Sbjct: 281 AEPFLFVDE-----FLTYLFSRENSIWDEKYDAVDMQ-DMNNPLSHYWISSSHNTYLTGD 334
Query: 340 QLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAET 399
QL SS E Y + L GCRC+ELD W G P+ +P I HG+T TT++ DV++AI +
Sbjct: 335 QLRSESSPEAYIRCLRMGCRCIELDCWDG--PDGKPVIYHGWTRTTKIKFDDVVQAIKDH 392
Query: 400 AFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDL 459
AF TS +PVILS E H S +QQ MA+ + +FGD LL +P + A LPSP L
Sbjct: 393 AFVTSSFPVILSIEEHC-SVEQQRHMAKAFKEVFGDLLLTKPTE----ASADQLPSPSQL 447
Query: 460 MGRILVKNKK 469
+I++K+KK
Sbjct: 448 REKIIIKHKK 457
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 65.9 bits (159), Expect = 2e-10
Identities = 88/358 (24%), Positives = 153/358 (42%), Gaps = 67/358 (18%)
Query: 871 QRARQLAALIGESEAQAGQETCQDTQSQQLGSQPSSNPTPSPLDASPRR--PPGPTTSPA 928
+ A++ + G + + + + + P+ +P PSP A P++ PP T + A
Sbjct: 512 EEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDA 571
Query: 929 STSLSSPGQRDDLIASILSEVAPTPLDELRGHKALVKLRSRQERDLRELRKKHQRKAVTL 988
+ S P + S P+ + +L + + R RE R++ +++
Sbjct: 572 AVLTSPPAPAPPVTPS-------KPMAGTTDREEATRLLAEKRRQAREQREREEQE---- 620
Query: 989 TRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKEGEDEAKRYQEFQNRQVQSLLELREA 1048
RRL QAE R+R L A + E E E EA+R +E + R+ +A
Sbjct: 621 -RRL-------QAERDKRMREEQL--AREAEARAEREAEARRREEQEARE--------KA 662
Query: 1049 QVDAEAQRRLEHLR-QALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSIS 1107
Q + E Q RL+ + +A R RE +A + +R K ++E++ ++ RKR I
Sbjct: 663 QAEQEEQERLQKQKEEAEARSRE---EAERQRLEREKHFQQQEQERQER---RKRLEEIM 716
Query: 1108 EAKMRDKHKKEAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPK 1167
K +++E++E ++ ++ N+ E K R Q++ +Q +EEP
Sbjct: 717 ------KRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQ---KEEP- 766
Query: 1168 LLAQLAQECQEQRARLPQEIRRSLLG-EMPEGLGDG--PLVACASNGHAP-GSSGHLS 1221
+PQE + SL E+P L +G PL A NG + G SG S
Sbjct: 767 ---------------IPQEPQWSLPSKELPASLVNGLQPLPAHQENGFSTNGPSGDKS 809
Score = 42.7 bits (99), Expect = 0.002
Identities = 45/211 (21%), Positives = 81/211 (38%), Gaps = 13/211 (6%)
Query: 446 PLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPD--SAGRKRPLEQSNSALSESSAATEP 503
P P P + GR+ K + + PSA GP+ S ++R + SA S A +
Sbjct: 491 PPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPA 550
Query: 504 SSPQLGSPSSDSCPGLSNGEEVGLEK-----PSLEPQKSL-GDEGLNRGPYVLGPADRED 557
SP P + P + + L P + P K + G +L R+
Sbjct: 551 PSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQA 610
Query: 558 EEEDEEEEE----QTDPKKPTTDEGTA-SSEVNATEEMSTLVNYIEPVKFKSFEAARKRN 612
E+ E EE+ Q + K +E A +E A E + + K+ ++
Sbjct: 611 REQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQE 670
Query: 613 KCFEMSSFVETKAMEQLTKSPMEFVEYNKQQ 643
+ + E ++ E+ + +E ++ +QQ
Sbjct: 671 RLQKQKEEAEARSREEAERQRLEREKHFQQQ 701
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 63.2 bits (152), Expect = 2e-09
Identities = 67/291 (23%), Positives = 134/291 (46%), Gaps = 23/291 (7%)
Query: 893 QDTQSQQLGSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPT 952
Q +Q+++LG P A PP ++ ++ P Q + + E
Sbjct: 542 QHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQ 601
Query: 953 PLDELRGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGAL 1012
L++ + H L S+QE+ +++LR+K ++ RL Q+ + R RL+
Sbjct: 602 VLEQDQRH----LLESKQEK-MQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQK--- 653
Query: 1013 GGAADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRL---- 1068
A + E+ + E+E++R + QVQS + E Q+ AE + L+ LR+ L+
Sbjct: 654 --AIEEEEARMREEESQRL-SWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAE 710
Query: 1069 REVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRH 1128
R + N ++LKE E +K Q L+ + ++ + + + + +++ + + + H
Sbjct: 711 RASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEH 770
Query: 1129 ITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQ 1179
E + RL + + +H +V+ Q+ +Q+ ++E AQL Q+C Q
Sbjct: 771 SAE----LERLCSSLEAKHREVVSSLQKKIQEAQQKEE---AQL-QKCLGQ 813
Score = 55.8 bits (133), Expect = 2e-07
Identities = 61/314 (19%), Positives = 142/314 (45%), Gaps = 16/314 (5%)
Query: 884 EAQAGQETCQDTQSQQLGSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIA 943
E GQE +D + +++ P+ +P P PP + A ++ ++ +A
Sbjct: 548 ELGPGQEEAEDPE-EKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAM------EEAVA 600
Query: 944 SILSEVAPTPLD--ELRGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQA 1001
+L + L+ + + + KL +E ++ L ++ ++ +L RL + + +A
Sbjct: 601 QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 660
Query: 1002 EGRCRLRPGALGGAADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHL 1061
R A V+ + + +++ R + Q +Q L E E+Q AE +
Sbjct: 661 RMREEESQRLSWLRAQVQSSTQADEDQIRAE--QEASLQKLREELESQQKAERASLEQKN 718
Query: 1062 RQALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAEL 1121
RQ L++L+E + + ++ L E+ ++L++ L+ +R +++ + + E
Sbjct: 719 RQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLC 778
Query: 1122 TEINRRHITESVNSI-RRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLA---QLAQECQ 1177
+ + +H E V+S+ ++++EAQ++ +L QV ++ ++ + +L+ +
Sbjct: 779 SSLEAKH-REVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLR 837
Query: 1178 EQRARLPQEIRRSL 1191
E+R + E R L
Sbjct: 838 EKRQEVEGEHERRL 851
Score = 42.7 bits (99), Expect = 0.002
Identities = 48/183 (26%), Positives = 82/183 (44%), Gaps = 30/183 (16%)
Query: 956 ELRGHKA--LVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALG 1013
EL GH L +L+ ER+L +R++ ++ L RR E +L+ L
Sbjct: 879 ELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRR--------HREQERKLQDLELD 930
Query: 1014 GAADVEDTK------EGEDEAKRYQEFQNRQVQSLLELREAQVDA------EAQRRLEHL 1061
+D K E ++E R ++ Q VQ + L+ + A EAQ+ HL
Sbjct: 931 LETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHL 990
Query: 1062 RQALQRLREVV--LDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEA 1119
Q+ Q+LRE++ L A + + ++ + + ++LQK H S EA+ + K
Sbjct: 991 LQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQK------HFSSLEAEAQKKQHLLR 1044
Query: 1120 ELT 1122
E+T
Sbjct: 1045 EVT 1047
Score = 42.4 bits (98), Expect = 0.003
Identities = 79/373 (21%), Positives = 157/373 (42%), Gaps = 49/373 (13%)
Query: 864 KHVSLMDQRARQLAALIGESEAQAGQETCQDTQ----SQQLGSQPSSNPTPSPLDASPRR 919
K SL R R L I E EA+ +E Q Q +Q + + +AS ++
Sbjct: 640 KEQSLSSLRER-LQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQK 698
Query: 920 PPGPTTSPASTSLSSPGQRD-DLIASILSEVAPTPLDELRG-----HKALVKLRSRQERD 973
S +S Q++ ++ + E+ + E KAL +LR + E +
Sbjct: 699 LREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGE 758
Query: 974 LRE----LRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKEGEDEAK 1029
+E L K+H + L L + + + +++ A ++ G+ E +
Sbjct: 759 RKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCL-GQVEHR 817
Query: 1030 RYQEFQN-----RQVQSLLELREAQVDAEAQRRLEHLRQALQRL---------------R 1069
+Q+ + ++ SLL + +V+ E +RRL+ +++ Q++ R
Sbjct: 818 VHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQR 877
Query: 1070 EVVLDANTTQFKRLKEMNERE-----KKELQKILDRKRHNSISEAKMRDKHKKEAELTEI 1124
+L T + +RL+ +ERE +++ +++ D +R + E K++D E +L E
Sbjct: 878 AELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQD---LELDL-ET 933
Query: 1125 NRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLP 1184
+ + + + EE ++ +L+ Q+QV L EE Q +E Q++ L
Sbjct: 934 RAKDVKARLALLEVQEETARREKQQLLDVQRQV--ALKSEEATATHQQLEEAQKEHTHLL 991
Query: 1185 QEIR--RSLLGEM 1195
Q + R +L E+
Sbjct: 992 QSNQQLREILDEL 1004
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 60.5 bits (145), Expect = 1e-08
Identities = 55/214 (25%), Positives = 94/214 (43%), Gaps = 20/214 (9%)
Query: 904 PSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGHKAL 963
P+ P P+ A P P P P +S+P + AS+ + T +E L
Sbjct: 427 PAMAPAPASAPA-PASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEA---TRL 482
Query: 964 VKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKE 1023
+ + R R+ RE ++ +R+ L R+ + LAQ AE R R E+++
Sbjct: 483 LAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRRE---------EESRR 533
Query: 1024 GEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLE---HLRQALQRLREVVLDANTTQF 1080
E E R +E Q ++ LRE + AQR+ E +R+ +R+R+ F
Sbjct: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQ----EREKHF 589
Query: 1081 KRLKEMNEREKKELQKILDRKRHNSISEAKMRDK 1114
+R ++ KK L++I+ R R ++ K D+
Sbjct: 590 QREEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
Score = 32.3 bits (72), Expect = 2.9
Identities = 26/117 (22%), Positives = 57/117 (48%), Gaps = 10/117 (8%)
Query: 1084 KEMNEREKKELQKILDRKRH---NSISEAKMRDKHKKEAELTEINRRHITESV------N 1134
+E ERE++E +++ +KR ++E + + ++ L R E +
Sbjct: 494 REKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEER 553
Query: 1135 SIRRLEEAQK-QRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRS 1190
++R EEA++ QR A ++ +++ +E K + QE E++ RL + ++R+
Sbjct: 554 ALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRT 610
Score = 31.2 bits (69), Expect = 6.4
Identities = 26/103 (25%), Positives = 44/103 (42%), Gaps = 10/103 (9%)
Query: 1090 EKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLEEAQKQRHDR 1149
EK+ L + K E + ++ K+E + T RRLE Q +
Sbjct: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQARE--- 541
Query: 1150 LVAGQQQVLQQLAEE---EPKLLAQLAQECQEQRARLPQEIRR 1189
+++ LQ+ AEE + A+ AQ +E+ AR+ +E R
Sbjct: 542 ----KEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER 580
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 58.9 bits (141), Expect = 3e-08
Identities = 55/228 (24%), Positives = 103/228 (45%), Gaps = 19/228 (8%)
Query: 970 QERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKEGEDEAK 1029
+ R+L ELR+K + + R D + Q + E R R L E+ K E+E +
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL----RKEEEKLQEEEPQ 266
Query: 1030 RYQEFQNRQVQ----SLLELREAQVDAEAQ----RRLEHLRQALQRLREVVLDANTTQFK 1081
R +E Q + Q ELR + + E Q RR + LR+ + R + Q +
Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQE 326
Query: 1082 RLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLEE 1141
R ++ ER +++L++ + +R + + ++E E E R E ++L
Sbjct: 327 RREQQEERREQQLRREQEERREQQL-------RREQEEERREQQLRREQEEERREQQLRR 379
Query: 1142 AQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRR 1189
Q+ R ++ + +QQ+ ++ + L + Q +EQ+ R Q++RR
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 427
Score = 54.3 bits (129), Expect = 7e-07
Identities = 57/245 (23%), Positives = 111/245 (45%), Gaps = 18/245 (7%)
Query: 967 RSRQERDLR--ELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKE- 1023
R R+E +L+ E + H+++ RR D Q QAE + L + + +E
Sbjct: 739 RRRRESELQWQEEERAHRQQQEEEQRR--DFTWQWQAEEKSERGRQRLSARPPLREQRER 796
Query: 1024 ---GEDEAKRYQEF---QNRQVQSLLELREAQVDAEAQRRLEHL--RQALQRLREVVLDA 1075
E+ +R Q F + + Q + RE + + + E L R+ Q+L+E
Sbjct: 797 QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGL 856
Query: 1076 NTTQFKRLKEMNEREKK---ELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITES 1132
Q +R + R++K +L++ R+RH ++ ++++ +KE +L + +
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916
Query: 1133 VNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLL 1192
RR +E ++Q + Q++ +QL EE + + +E Q ++ + Q+ LL
Sbjct: 917 EREKRRRQEQERQYREEEQLQQEE--EQLLREEREKRRRQERERQYRKDKKLQQKEEQLL 974
Query: 1193 GEMPE 1197
GE PE
Sbjct: 975 GEEPE 979
Score = 53.5 bits (127), Expect = 1e-06
Identities = 61/244 (25%), Positives = 108/244 (44%), Gaps = 14/244 (5%)
Query: 957 LRGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGR-CRLRPGALGGA 1015
LR + L + + + R+ +E R++ Q + R L + Q E R +LR
Sbjct: 300 LRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEER 359
Query: 1016 ADVEDTKEGEDEAKRYQ---EFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVV 1072
+ + +E E+E + Q E Q R+ Q L RE Q+ E Q R E + Q+LR
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQL--RREQQLRREQQLRREQQLRREQQLRREQ 417
Query: 1073 LDANTTQFKRLKEMNEREKKELQKILDRK-------RHNSISEAKMRDKHKKEAELTEIN 1125
Q +R +E E+K Q+ +++ R + + + ++H++E ++
Sbjct: 418 QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK 477
Query: 1126 RRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQ 1185
R E +LEE +++R + QQ +Q E +L Q +E +QR R Q
Sbjct: 478 RDQEEERRERWLKLEE-EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ 536
Query: 1186 EIRR 1189
++RR
Sbjct: 537 QLRR 540
Score = 53.5 bits (127), Expect = 1e-06
Identities = 58/247 (23%), Positives = 109/247 (44%), Gaps = 16/247 (6%)
Query: 955 DELRGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGG 1014
++ R ++ +L+ +E+ LRE R+K +R+ R L Q + + LG
Sbjct: 925 EQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ--------LLGE 976
Query: 1015 AADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLD 1074
+ +E E + + +E Q + Q L E RE + E +R+ + Q +++ +
Sbjct: 977 EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE 1036
Query: 1075 ANTTQFKRLKEMNEREKKELQ----KILDRKRHNSISEAKMRDKHKKEAELTEINRRHIT 1130
+ + +E RE++ELQ ++L +R ++ +++KE EL + + +
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETR-RRQELERQYRKEEELQQEEEQLLR 1095
Query: 1131 ESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRS 1190
E RR E ++ R + + QQ+ Q L EE K Q + + + QE
Sbjct: 1096 EEPEKRRRQERERQCREEEEL--QQEEEQLLREEREKRRRQELERQYREEEEVQQE-EEQ 1152
Query: 1191 LLGEMPE 1197
LL E PE
Sbjct: 1153 LLREEPE 1159
Score = 48.9 bits (115), Expect = 3e-05
Identities = 48/222 (21%), Positives = 100/222 (45%), Gaps = 15/222 (6%)
Query: 965 KLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKEG 1024
+L+ +E+ LRE R+K +R+ R D L Q + + L + +E
Sbjct: 995 ELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQ--------LLREEREKRRLQER 1046
Query: 1025 EDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRLK 1084
E + + +E Q + Q L E RE + E +R+ + Q +++ + + ++ +
Sbjct: 1047 ERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER 1106
Query: 1085 EMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLEEAQK 1144
E RE++ELQ + + + + ++E E + + + R EE +K
Sbjct: 1107 ERQCREEEELQ-----QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR-EEPEK 1160
Query: 1145 QRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQE 1186
+R L Q + ++L +EE +LL + ++ +++R R +E
Sbjct: 1161 RRRQEL-ERQYREEEELQQEEEQLLREEQEKRRQERERQYRE 1201
Score = 48.1 bits (113), Expect = 5e-05
Identities = 49/220 (22%), Positives = 100/220 (45%), Gaps = 31/220 (14%)
Query: 964 VKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKE 1023
+KL + R+ +E R++ R+ R L + + E R + R
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERRE--QRLKRQEEEERLQQR-------------LR 533
Query: 1024 GEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRL 1083
E + +R QE + Q+ RE + E +RR + L++ + R+ +L + +R
Sbjct: 534 SEQQLRREQEERREQLLK----REEEKRLEQERREQRLKREQEERRDQLLKRE--EERRQ 587
Query: 1084 KEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLEEAQ 1143
+ + +++ L++ L R+ + + + R++ K E E R+ + +S EE +
Sbjct: 588 QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKS-------EEQE 640
Query: 1144 KQRHDRLVAGQQQVLQQLA---EEEPKLLAQLAQECQEQR 1180
++R +L QQ+ +Q EEE +L +L +E +E+R
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680
Score = 45.4 bits (106), Expect = 3e-04
Identities = 58/237 (24%), Positives = 100/237 (42%), Gaps = 23/237 (9%)
Query: 965 KLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKEG 1024
+LR QE + E + + +R+ L R Q E R L+ + E K+
Sbjct: 424 QLRREQEEERHEQKHEQERREQRLKRE--------QEERRDWLKREEETERHEQERRKQ- 474
Query: 1025 EDEAKRYQEFQNRQVQSLLE---LREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFK 1081
+ KR QE + R+ LE RE Q E Q R E + QRL+ + Q
Sbjct: 475 --QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL 532
Query: 1082 RLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLEE 1141
R ++ RE++E ++ L ++ E + R++ K + ++ E +RL+
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR 592
Query: 1142 AQKQR-HDRLVAGQQQVLQQLAEEEPKLLAQLAQE--------CQEQRARLPQEIRR 1189
Q++R RL + + L+Q E +L + +E +EQ R Q++RR
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRR 649
Score = 44.7 bits (104), Expect = 6e-04
Identities = 54/238 (22%), Positives = 101/238 (42%), Gaps = 32/238 (13%)
Query: 965 KLRSRQERDLRE--LRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTK 1022
+LR QE + RE LR++ Q + RR + Q +LR E
Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR---------EQQL 413
Query: 1023 EGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKR 1082
E + +R Q+ + Q + E + Q +RR + L++ + R+ + KR
Sbjct: 414 RREQQLRREQQLRREQEEERHEQKHEQ-----ERREQRLKREQEERRDWL--------KR 460
Query: 1083 LKEMNEREKKELQKILDRKRHNSISEAKMR---DKHKKEAELTEINRRHITESVNSIRRL 1139
+E E++ ++ L R + E ++ ++ +++ E E R E R
Sbjct: 461 EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLK 520
Query: 1140 EEAQKQRHDRLVAGQQQVLQQLAEEEPKLL-----AQLAQECQEQRARLPQEIRRSLL 1192
+ +++R + + +QQ+ ++ E +LL +L QE +EQR + QE RR L
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578
Score = 44.3 bits (103), Expect = 7e-04
Identities = 52/233 (22%), Positives = 105/233 (45%), Gaps = 20/233 (8%)
Query: 968 SRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQA-EGRCRLRPGALGGAADVEDTKEGED 1026
SRQERD + ++ + + R+ ++ Q + EG+ +LR + E + +
Sbjct: 1573 SRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQERE 1632
Query: 1027 EAK-----RYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQ-----RLREVVLDAN 1076
E + R ++F + Q + RE Q+ + R+ Q LQ +LR D
Sbjct: 1633 EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK 1692
Query: 1077 TTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSI 1136
+ ++ ERE+K LQ+ +R + + ++ ++E E ++ R+
Sbjct: 1693 FREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE------RY 1746
Query: 1137 RRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRR 1189
R++ E ++ R +R +QQ+ +Q + + + QL QE +EQ+ R + R+
Sbjct: 1747 RKILEEEQLRPER---EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRK 1796
Score = 43.9 bits (102), Expect = 0.001
Identities = 41/179 (22%), Positives = 85/179 (47%), Gaps = 6/179 (3%)
Query: 1022 KEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFK 1081
+E E + + ++ Q + Q L E RE + E +R+ ++ Q+ +++ + + +
Sbjct: 924 QEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRR 983
Query: 1082 RLKEMNEREKKELQ---KILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRR 1138
+ +E RE++ELQ + L R+ + +++K+ EL + + + E RR
Sbjct: 984 QEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE-REKRR 1042
Query: 1139 LEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPE 1197
L+E ++Q + Q++ +QL EE + + E Q ++ Q+ LL E PE
Sbjct: 1043 LQERERQYREEEELQQEE--EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099
Score = 43.5 bits (101), Expect = 0.001
Identities = 63/265 (23%), Positives = 111/265 (41%), Gaps = 31/265 (11%)
Query: 952 TPLDELR-----GHKALVKLRSRQERDLRELR-----------KKHQRKAVTLTRRLLDG 995
T LDE + G ++L++ R RQE D R ++ ++K R L +G
Sbjct: 93 TGLDEEKRARCDGKESLLQDR-RQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEG 151
Query: 996 LAQAQAEGRCRLRPGALGGAADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQ 1055
Q++ + R R +E ++ +R E + Q E E D E
Sbjct: 152 EEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFP-DEEQL 210
Query: 1056 RRLEHLRQALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEA---KMR 1112
RR E L + E Q + +E E+E ++ + +L RK + E + R
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL-RKEEEKLQEEEPQRQR 269
Query: 1113 DKHKKEAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQL 1172
+ ++E +L ++ R+ + R+ EE Q+QR R +Q L++ EEE + +
Sbjct: 270 ELQEEEEQLRKLERQELRRE----RQEEEQQQQRLRR-----EQQLRRKQEEERREQQEE 320
Query: 1173 AQECQEQRARLPQEIRRSLLGEMPE 1197
+E QE+R + + + L E E
Sbjct: 321 RREQQERREQQEERREQQLRREQEE 345
Score = 43.1 bits (100), Expect = 0.002
Identities = 40/170 (23%), Positives = 79/170 (46%), Gaps = 17/170 (10%)
Query: 1027 EAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQ-------RLREVVLDANTTQ 1079
E + + + + + + LLELR + + Q+R E + Q R RE VL +
Sbjct: 200 ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL---RKE 256
Query: 1080 FKRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRL 1139
++L+E + ++ELQ+ ++ R E + R++ ++E + + R +RR
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQLRKLERQELR-RERQEEEQQQQRLRRE------QQLRRK 309
Query: 1140 EEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRR 1189
+E +++ QQ+ +Q E + L + +E +EQ+ R QE R
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEER 359
Score = 42.7 bits (99), Expect = 0.002
Identities = 55/216 (25%), Positives = 93/216 (43%), Gaps = 17/216 (7%)
Query: 969 RQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVE-DTKEGEDE 1027
RQERD + L ++ Q + ++L + E L+ G E D K E+E
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE 1697
Query: 1028 AK-RYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRLKEM 1086
+ R QE + + +Q +LR E +R+ Q Q + L K L+E
Sbjct: 1698 QQLRRQERERKFLQEEQQLRRQ----ELERKFREEEQLRQETEQEQLRRQERYRKILEEE 1753
Query: 1087 NEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLEEAQKQR 1146
R ++E Q++ ++R E + + ++E +L ES R E+ +++R
Sbjct: 1754 QLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRS------QESDRKFREEEQLRQER 1807
Query: 1147 HDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRAR 1182
++ + QQ+ + EEE QL E QEQR R
Sbjct: 1808 EEQQLRPQQRDGKYRWEEE-----QLQLEEQEQRLR 1838
Score = 38.1 bits (87), Expect = 0.052
Identities = 46/235 (19%), Positives = 100/235 (42%), Gaps = 16/235 (6%)
Query: 967 RSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKEGED 1026
R + R R R++ +R L R ++ L Q + + RL+ + K E
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ-RLKREEPEEERRQQLLKSEEQ 639
Query: 1027 EAKRYQEFQNRQVQSLLE-LREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRLKE 1085
E +R Q+ + Q + + L+ + + ++RL+ + +R +E+ + +R+K
Sbjct: 640 EERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS 699
Query: 1086 MNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITE----SVNSIRRLEE 1141
+ + +L+ D ++ S + ++ ++ E E RR +E R ++
Sbjct: 700 RIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQ 759
Query: 1142 AQKQRHD---------RLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRAR-LPQE 1186
++QR D + G+Q++ + E + A+E Q++ R LP+E
Sbjct: 760 EEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEE 814
Score = 38.1 bits (87), Expect = 0.052
Identities = 52/234 (22%), Positives = 100/234 (42%), Gaps = 26/234 (11%)
Query: 967 RSRQERDLRELRKKHQRKAVTLTRRLL---DGLAQAQAEGRCRLRPGALGGAADVEDTKE 1023
R +E++L+ L ++ Q + ++L DGL + Q R + + +E+ ++
Sbjct: 824 RREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERK 883
Query: 1024 GEDE---AKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF 1080
AK + Q R+ Q LL+ E ++ E + + Q Q E Q
Sbjct: 884 RRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREE-------EQL 936
Query: 1081 KRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLE 1140
++ +E RE++E ++ +R+R +++K+ +L + + + E RR E
Sbjct: 937 QQEEEQLLREEREKRRRQERER-----------QYRKDKKLQQKEEQLLGEEPEKRRRQE 985
Query: 1141 EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGE 1194
+K R + + QQ+ Q L EE K Q + ++ L QE + L E
Sbjct: 986 REKKYREEEEL--QQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037
Score = 37.7 bits (86), Expect = 0.068
Identities = 36/162 (22%), Positives = 71/162 (43%), Gaps = 10/162 (6%)
Query: 1019 EDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTT 1078
+ ++ E E +R+Q+ + E E + EA+RR ++ Q LRE
Sbjct: 1274 QQERDREQERRRWQQRDRHFPEE--EQLEREEQKEAKRRDRKSQEEKQLLRE------ER 1325
Query: 1079 QFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINR-RHITESVNSIR 1137
+ KR ++ +R+ +E +++L + + + RD+ +E EL + R E +R
Sbjct: 1326 EEKRRRQETDRKFREEEQLLQEREEQPLRRQE-RDRKFREEELRHQEQGRKFLEEEQRLR 1384
Query: 1138 RLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQ 1179
R E +K + Q+ QQL ++ + + Q+ Q
Sbjct: 1385 RQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQ 1426
Score = 37.7 bits (86), Expect = 0.068
Identities = 51/257 (19%), Positives = 110/257 (42%), Gaps = 36/257 (14%)
Query: 969 RQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCR--------LRPGALGGAADVED 1020
RQERD R+ R++ R R+ L+ Q + R R LR G +
Sbjct: 1496 RQERD-RKFREQELRSQEP-ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDR 1553
Query: 1021 TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF 1080
++ +E + QE + +Q+ R+ +++ + RR E R+ ++ +++ Q
Sbjct: 1554 DRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQL 1613
Query: 1081 KRLKE---------MNEREKKEL------QKILDRKRHNSISEAKMRDKHKKEAELTEIN 1125
++ ++ + ERE+++L +K L+ + E + + +H ++ + E
Sbjct: 1614 RQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEE 1673
Query: 1126 RRHITESVNSIRRLEEAQK-----------QRHDRLVAGQQQVLQQLAEEEPKLLAQLAQ 1174
+ +RR E +K +R + + +QQ+ +Q E + + QL Q
Sbjct: 1674 QLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQ 1733
Query: 1175 ECQEQRARLPQEIRRSL 1191
E ++++ R + R+ L
Sbjct: 1734 ETEQEQLRRQERYRKIL 1750
Score = 37.0 bits (84), Expect = 0.12
Identities = 47/257 (18%), Positives = 104/257 (40%), Gaps = 36/257 (14%)
Query: 958 RGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAAD 1017
R ++ +L+ +E+ L E R+ +R+ + R + L Q + + L +
Sbjct: 1048 RQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ--------LLREEPE 1099
Query: 1018 VEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANT 1077
+E E + + +E Q + Q L E RE + E +R+ + Q +++ +
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE 1159
Query: 1078 TQFKRLKEMNEREKKELQKILDR-----------------KRHNSISEAKMRDKHKKEAE 1120
+ ++ E RE++ELQ+ ++ + + K + +++ E +
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ 1219
Query: 1121 LTEINRRHITESVNSIR--------RLEEAQKQRHD---RLVAGQQQVLQQLAEEEPKLL 1169
+++ + E N++R R E +Q D R QQ + L E++ +
Sbjct: 1220 RSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDR 1279
Query: 1170 AQLAQECQEQRARLPQE 1186
Q + Q++ P+E
Sbjct: 1280 EQERRRWQQRDRHFPEE 1296
Score = 36.6 bits (83), Expect = 0.15
Identities = 46/234 (19%), Positives = 106/234 (45%), Gaps = 8/234 (3%)
Query: 967 RSRQERDLRELRKKHQRKAVTLTRRLLDG--LAQAQAEGRCRLRPGALGGAADVEDTKEG 1024
R R + +L ++ Q++A R+ + L + + E + R + + + +E
Sbjct: 1289 RDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQER 1348
Query: 1025 EDEAKRYQE----FQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF 1080
E++ R QE F+ +++ + R+ + + RR E R+ L+ +++ Q
Sbjct: 1349 EEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQL 1408
Query: 1081 KRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLE 1140
++ ++ RE+++ +R R E ++R + ++E + E ++ E R E
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFREEEQQVR-RQERERKFLEEEQQLRQERHRKFREEE 1467
Query: 1141 EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGE 1194
+ ++R ++ + Q++ + L EE+ + ++ +EQ R QE R L E
Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELR-SQEPERKFLEE 1520
Score = 36.6 bits (83), Expect = 0.15
Identities = 54/243 (22%), Positives = 99/243 (40%), Gaps = 26/243 (10%)
Query: 961 KALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCR---LRPGALGGAAD 1017
K L++ ++R +E +K + + L R L + + + + R LR G
Sbjct: 1318 KQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFL 1377
Query: 1018 VEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANT 1077
E+ + E +R +F + Q + RE Q+ + R+ Q L R D
Sbjct: 1378 EEEQRLRRQERER--KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER---DRKF 1432
Query: 1078 TQFKRLKEMNEREKK--ELQKILDRKRHNSISEAKMRDKHKKEAELTEINR-RHITESVN 1134
+ ++ ERE+K E ++ L ++RH E + + ++E +L R R E
Sbjct: 1433 REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ 1492
Query: 1135 SIRRLEEAQKQRHDRLVAGQ--------------QQVLQQLAEEEPKLLAQ-LAQECQEQ 1179
+RR E +K R L + + QQ ++ +EE +L Q Q+ ++
Sbjct: 1493 QLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552
Query: 1180 RAR 1182
R R
Sbjct: 1553 RDR 1555
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 58.9 bits (141), Expect = 3e-08
Identities = 55/223 (24%), Positives = 111/223 (49%), Gaps = 21/223 (9%)
Query: 961 KALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVED 1020
+ +++ R R E+ E +K+ ++K + + + AE + + + A
Sbjct: 579 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAA--------- 629
Query: 1021 TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF 1080
K E EA+R QE + R+ LR Q + E +R E L++ + +E + A +
Sbjct: 630 KKMEEVEARRKQEEEARR------LRWLQQEEEERRHQELLQKKKEEEQERLRKA--AEA 681
Query: 1081 KRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLE 1140
KRL E E+E++E ++ R++ E + +++ ++E +L E RR E + + R L+
Sbjct: 682 KRLAEQREQERREQER---REQERREQERREQERREQERQLAEQERRREQERLQAERELQ 738
Query: 1141 EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQ-LAQECQEQRAR 1182
E +K + Q+++ ++ +EE + LA+ QE QE++A+
Sbjct: 739 EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 781
Score = 52.4 bits (124), Expect = 3e-06
Identities = 45/166 (27%), Positives = 83/166 (50%), Gaps = 16/166 (9%)
Query: 1029 KRYQEFQN-RQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRLKEMN 1087
K Q +N R+ + +LR +V+ + +RRLE ++ + VL A +R+++M
Sbjct: 537 KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR----ERVEQMK 592
Query: 1088 EREKKELQKI---LDRKRHNSISEAKMRDKHKKEAELTEIN----RRHITESVNSIRRLE 1140
E +KK++++ +D K + E +K KK+A ++ RR E +R L+
Sbjct: 593 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652
Query: 1141 -EAQKQRHDRLVAGQQQVLQQ---LAEEEPKLLAQLAQECQEQRAR 1182
E +++RH L+ +++ Q+ A E +L Q QE +EQ R
Sbjct: 653 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 698
Score = 38.5 bits (88), Expect = 0.040
Identities = 39/184 (21%), Positives = 86/184 (46%), Gaps = 18/184 (9%)
Query: 1015 AADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLRE---V 1071
A + K ED+ +R +E + ++ + L ++ +A+ R+E +++ ++ E
Sbjct: 551 AEQLRRQKVEEDKRRRLEEVKLKREERLRKV------LQARERVEQMKEEKKKQIEQKFA 604
Query: 1072 VLDANTTQFK--RLKEMNEREKKELQKILD----RKRHNSISEAKMRDKHKKEAELTEIN 1125
+D T + K RL E ++K +K+ + RK+ + + ++E E+
Sbjct: 605 QIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELL 664
Query: 1126 RRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQ 1185
++ E +R+ EA++ R Q++ Q+ E+E + + QE +EQ +L +
Sbjct: 665 QKKKEEEQERLRKAAEAKRLAEQR---EQERREQERREQERREQERREQERREQERQLAE 721
Query: 1186 EIRR 1189
+ RR
Sbjct: 722 QERR 725
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 58.9 bits (141), Expect = 3e-08
Identities = 55/223 (24%), Positives = 111/223 (49%), Gaps = 21/223 (9%)
Query: 961 KALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVED 1020
+ +++ R R E+ E +K+ ++K + + + AE + + + A
Sbjct: 575 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAA--------- 625
Query: 1021 TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF 1080
K E EA+R QE + R+ LR Q + E +R E L++ + +E + A +
Sbjct: 626 KKMEEVEARRKQEEEARR------LRWLQQEEEERRHQELLQKKKEEEQERLRKA--AEA 677
Query: 1081 KRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLE 1140
KRL E E+E++E ++ R++ E + +++ ++E +L E RR E + + R L+
Sbjct: 678 KRLAEQREQERREQER---REQERREQERREQERREQERQLAEQERRREQERLQAERELQ 734
Query: 1141 EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQ-LAQECQEQRAR 1182
E +K + Q+++ ++ +EE + LA+ QE QE++A+
Sbjct: 735 EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 777
Score = 52.8 bits (125), Expect = 2e-06
Identities = 45/170 (26%), Positives = 85/170 (50%), Gaps = 16/170 (9%)
Query: 1025 EDEAKRYQEFQN-RQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRL 1083
+ + K Q +N R+ + +LR +V+ + +RRLE ++ + VL A +R+
Sbjct: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR----ERV 584
Query: 1084 KEMNEREKKELQKI---LDRKRHNSISEAKMRDKHKKEAELTEIN----RRHITESVNSI 1136
++M E +KK++++ +D K + E +K KK+A ++ RR E +
Sbjct: 585 EQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 644
Query: 1137 RRLE-EAQKQRHDRLVAGQQQVLQQ---LAEEEPKLLAQLAQECQEQRAR 1182
R L+ E +++RH L+ +++ Q+ A E +L Q QE +EQ R
Sbjct: 645 RWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 694
Score = 38.5 bits (88), Expect = 0.040
Identities = 39/184 (21%), Positives = 86/184 (46%), Gaps = 18/184 (9%)
Query: 1015 AADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLRE---V 1071
A + K ED+ +R +E + ++ + L ++ +A+ R+E +++ ++ E
Sbjct: 547 AEQLRRQKVEEDKRRRLEEVKLKREERLRKV------LQARERVEQMKEEKKKQIEQKFA 600
Query: 1072 VLDANTTQFK--RLKEMNEREKKELQKILD----RKRHNSISEAKMRDKHKKEAELTEIN 1125
+D T + K RL E ++K +K+ + RK+ + + ++E E+
Sbjct: 601 QIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELL 660
Query: 1126 RRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQ 1185
++ E +R+ EA++ R Q++ Q+ E+E + + QE +EQ +L +
Sbjct: 661 QKKKEEEQERLRKAAEAKRLAEQR---EQERREQERREQERREQERREQERREQERQLAE 717
Query: 1186 EIRR 1189
+ RR
Sbjct: 718 QERR 721
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 57.8 bits (138), Expect = 6e-08
Identities = 66/274 (24%), Positives = 124/274 (45%), Gaps = 25/274 (9%)
Query: 955 DELRGHKALVKLRSRQERDLRELR-KKHQRKAVTLTRRLLDGLAQAQAEGRCRLR----- 1008
D+L + + + +ERD E ++ + KA++L R L + + Q R +
Sbjct: 1447 DQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEM 1506
Query: 1009 PGALGGAADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDA--EAQRRLEHLRQALQ 1066
+ DV + +++KR E Q ++++ LE E ++ A +A+ RLE QA++
Sbjct: 1507 EDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK 1566
Query: 1067 RLREVVLDANTTQFKRLKEMNEREKKELQ-KILDRKRHNSISEAKMR----DKHKKEAEL 1121
E L Q + K+ R+ +E++ ++ D ++ S++ A + D EA +
Sbjct: 1567 AQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHI 1626
Query: 1122 TEINRRHITESVNSIRRLEEAQK---QRHDRLVAGQQQVLQQLAEEEPKL------LAQL 1172
N+ E++ +R+L+ K + D A ++++L Q E E KL + QL
Sbjct: 1627 DSANKNR-DEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQL 1685
Query: 1173 AQE--CQEQRARLPQEIRRSLLGEMPEGLGDGPL 1204
+E E+ R Q+ R L E+ G G L
Sbjct: 1686 QEELAAAERAKRQAQQERDELADEIANSSGKGAL 1719
Score = 46.6 bits (109), Expect = 1e-04
Identities = 53/204 (25%), Positives = 99/204 (48%), Gaps = 23/204 (11%)
Query: 1017 DVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRR----LEHL--RQALQRLRE 1070
D+E E E+E ++ + + +++Q ++ E Q++ E R LE + L++L E
Sbjct: 919 DLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEE 978
Query: 1071 --VVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRR- 1127
++L+ + + K++ E E L + S S AK+++KH EA +T++ R
Sbjct: 979 EQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKH--EAMITDLEERL 1036
Query: 1128 -----HITESVNSIRRLEEAQKQRHDRLVAGQQQVLQ---QLAEEEPKLLAQLAQECQE- 1178
E + R+LE D++ Q Q+ + QLA++E +L A LA+ +E
Sbjct: 1037 RREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEA 1096
Query: 1179 -QRARLPQEIR--RSLLGEMPEGL 1199
Q+ ++IR S + E+ E L
Sbjct: 1097 AQKNMALKKIRELESQISELQEDL 1120
Score = 31.6 bits (70), Expect = 4.9
Identities = 49/206 (23%), Positives = 94/206 (45%), Gaps = 41/206 (19%)
Query: 1025 EDEAKRYQEFQNRQVQSL-LELREAQVDAEAQR-RLEHLRQALQRLREVV--LDANTTQF 1080
+D + QE +NRQ SL +L++ + + + R +LE +A L + + L A
Sbjct: 1311 QDTQELLQE-ENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADM 1369
Query: 1081 KRLKEMN-------EREKKELQKILD--RKRH-------NSISEAKMRDKHKKEAELTEI 1124
K+ E + E K++LQK L+ +RH + + + K R + + + L ++
Sbjct: 1370 KKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL 1429
Query: 1125 NRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKL-------------LAQ 1171
+ + S LE+ QK + D+L+A ++ + + AEE + LA+
Sbjct: 1430 DHQR-----QSACNLEKKQK-KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLAR 1483
Query: 1172 LAQECQEQRARLPQEIRRSLLGEMPE 1197
+E EQ+A L + + + EM +
Sbjct: 1484 ALEEAMEQKAEL-ERLNKQFRTEMED 1508
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,926,512
Number of Sequences: 37866
Number of extensions: 2478427
Number of successful extensions: 24034
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 198
Number of HSP's successfully gapped in prelim test: 868
Number of HSP's that attempted gapping in prelim test: 17580
Number of HSP's gapped (non-prelim): 5229
length of query: 1234
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1120
effective length of database: 13,930,794
effective search space: 15602489280
effective search space used: 15602489280
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.