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Search of human proteins with 21361399
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361399 alpha isoform of regulatory subunit A, protein
phosphatase 2 [Homo sapiens]
(589 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361399 alpha isoform of regulatory subunit A, protein phosp... 1149 0.0
gi|32455246 beta isoform of regulatory subunit A, protein phosph... 1001 0.0
gi|32455244 beta isoform of regulatory subunit A, protein phosph... 996 0.0
gi|4826934 protein phosphatase 4, regulatory subunit 1 isoform b... 73 6e-13
gi|108936953 protein phosphatase 4, regulatory subunit 1 isoform... 73 6e-13
gi|17402886 HEAT-like repeat-containing protein isoform 1 [Homo ... 71 3e-12
gi|54607053 GCN1 general control of amino-acid synthesis 1-like ... 54 5e-07
gi|54112117 splicing factor 3b, subunit 1 isoform 1 [Homo sapiens] 50 6e-06
gi|23943912 phosphoinositide-3-kinase, regulatory subunit 4 [Hom... 41 0.003
gi|19923142 karyopherin beta 1 [Homo sapiens] 41 0.003
gi|241982712 TBP-interacting protein isoform 1 [Homo sapiens] 37 0.039
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 37 0.066
gi|90903231 huntingtin [Homo sapiens] 36 0.11
gi|23510381 transportin 1 isoform 2 [Homo sapiens] 36 0.11
gi|133925811 transportin 1 isoform 1 [Homo sapiens] 36 0.11
gi|157388904 HEAT repeat containing 2 [Homo sapiens] 35 0.15
gi|109948292 hypothetical protein LOC57614 [Homo sapiens] 35 0.19
gi|112420977 TBP-interacting protein isoform 2 [Homo sapiens] 34 0.33
gi|93102424 hypothetical protein LOC23116 [Homo sapiens] 34 0.33
gi|18034767 phosphorylated CTD interacting factor 1 [Homo sapiens] 34 0.33
gi|62460637 importin 4 [Homo sapiens] 34 0.43
gi|50086624 integrator complex subunit 4 [Homo sapiens] 34 0.43
gi|209969836 transportin 2 (importin 3, karyopherin beta 2b) iso... 33 0.96
gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isof... 33 0.96
gi|209969838 transportin 2 (importin 3, karyopherin beta 2b) iso... 32 1.6
gi|115430243 SCY1-like 1 isoform B [Homo sapiens] 32 2.1
gi|115430241 SCY1-like 1 isoform A [Homo sapiens] 32 2.1
gi|7657530 rhabdoid tumor deletion region protein 1 [Homo sapiens] 32 2.1
gi|50233846 olfactory receptor, family 13, subfamily C, member 3... 32 2.1
gi|88853059 diphthamide biosynthesis protein 2 isoform b [Homo s... 31 2.8
>gi|21361399 alpha isoform of regulatory subunit A, protein
phosphatase 2 [Homo sapiens]
Length = 589
Score = 1149 bits (2971), Expect = 0.0
Identities = 589/589 (100%), Positives = 589/589 (100%)
Query: 1 MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIY 60
MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIY
Sbjct: 1 MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIY 60
Query: 61 DEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHS 120
DEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHS
Sbjct: 61 DEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHS 120
Query: 121 PSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPM 180
PSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPM
Sbjct: 121 PSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPM 180
Query: 181 VRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDL 240
VRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDL
Sbjct: 181 VRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDL 240
Query: 241 EALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRA 300
EALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRA
Sbjct: 241 EALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRA 300
Query: 301 AASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDN 360
AASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDN
Sbjct: 301 AASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDN 360
Query: 361 TIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVR 420
TIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVR
Sbjct: 361 TIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVR 420
Query: 421 LAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHA 480
LAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHA
Sbjct: 421 LAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHA 480
Query: 481 TIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNV 540
TIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNV
Sbjct: 481 TIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNV 540
Query: 541 AKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA 589
AKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
Sbjct: 541 AKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA 589
>gi|32455246 beta isoform of regulatory subunit A, protein
phosphatase 2 isoform a [Homo sapiens]
Length = 601
Score = 1001 bits (2587), Expect = 0.0
Identities = 507/588 (86%), Positives = 548/588 (93%)
Query: 2 AAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYD 61
A DGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYD
Sbjct: 14 AGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYD 73
Query: 62 EDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSP 121
EDEVLLALAEQLG FT LVGGP++ HCLLPPLE+LATVEETVVRDKAVESLR IS EH+P
Sbjct: 74 EDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESLRQISQEHTP 133
Query: 122 SDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMV 181
LEA+FVPLVKRLA GDWFTSRTSACGLFSVCYPR S+AVKAE+RQ FR+LCSDDTPMV
Sbjct: 134 VALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMV 193
Query: 182 RRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLE 241
RRAAASKLGEFAKVLELD+VKSEI+P+F++LASDEQDSVRLLAVEACV+IAQLL Q+DLE
Sbjct: 194 RRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLE 253
Query: 242 ALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAA 301
LVMPTLRQAAEDKSWRVRYMVAD+F+ELQKA+GP+IT DL+PAFQNL+KDCEAEVRAA
Sbjct: 254 TLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAA 313
Query: 302 ASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNT 361
A+HKVKE ENL + RE +IM+QILP IKELVSD NQHVKSALASVIMGLS ILGK+NT
Sbjct: 314 AAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENT 373
Query: 362 IEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRL 421
IEHLLPLFLAQLKDECP+VRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRL
Sbjct: 374 IEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRL 433
Query: 422 AIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHAT 481
AIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAAT+NL KLV+KFG EWA T
Sbjct: 434 AIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNT 493
Query: 482 IIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVA 541
I+PKVL M+ DPNYLHRMTTLFCIN LSE CGQ+ITTK MLP VL+MAGD VANVRFNVA
Sbjct: 494 IVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVRFNVA 553
Query: 542 KSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA 589
KSLQKIGPILD + LQ EVKP+L+KL QD+D+DVKYFAQEA++VL+LA
Sbjct: 554 KSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLALA 601
>gi|32455244 beta isoform of regulatory subunit A, protein
phosphatase 2 isoform b [Homo sapiens]
Length = 667
Score = 996 bits (2576), Expect = 0.0
Identities = 504/586 (86%), Positives = 546/586 (93%)
Query: 2 AAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYD 61
A DGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYD
Sbjct: 14 AGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYD 73
Query: 62 EDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSP 121
EDEVLLALAEQLG FT LVGGP++ HCLLPPLE+LATVEETVVRDKAVESLR IS EH+P
Sbjct: 74 EDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESLRQISQEHTP 133
Query: 122 SDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMV 181
LEA+FVPLVKRLA GDWFTSRTSACGLFSVCYPR S+AVKAE+RQ FR+LCSDDTPMV
Sbjct: 134 VALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMV 193
Query: 182 RRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLE 241
RRAAASKLGEFAKVLELD+VKSEI+P+F++LASDEQDSVRLLAVEACV+IAQLL Q+DLE
Sbjct: 194 RRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLE 253
Query: 242 ALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAA 301
LVMPTLRQAAEDKSWRVRYMVAD+F+ELQKA+GP+IT DL+PAFQNL+KDCEAEVRAA
Sbjct: 254 TLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAA 313
Query: 302 ASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNT 361
A+HKVKE ENL + RE +IM+QILP IKELVSD NQHVKSALASVIMGLS ILGK+NT
Sbjct: 314 AAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENT 373
Query: 362 IEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRL 421
IEHLLPLFLAQLKDECP+VRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRL
Sbjct: 374 IEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRL 433
Query: 422 AIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHAT 481
AIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAAT+NL KLV+KFG EWA T
Sbjct: 434 AIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNT 493
Query: 482 IIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVA 541
I+PKVL M+ DPNYLHRMTTLFCIN LSE CGQ+ITTK MLP VL+MAGD VANVRFNVA
Sbjct: 494 IVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVRFNVA 553
Query: 542 KSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLS 587
KSLQKIGPILD + LQ EVKP+L+KL QD+D+DVKYFAQEA++V++
Sbjct: 554 KSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVVA 599
Score = 100 bits (248), Expect = 5e-21
Identities = 86/414 (20%), Positives = 165/414 (39%), Gaps = 10/414 (2%)
Query: 27 LRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDE-DEVLLALAEQLGTFTTLVGGPEY 85
+R + KL A L ++ +SE++P T DE D V L E + L+ +
Sbjct: 193 VRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDL 252
Query: 86 VHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRT 145
++P L A + VR + + P +P + L R
Sbjct: 253 ETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRA 312
Query: 146 SACGLFSVCYPRV-----SSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDN 200
+A + + + ++ Y + L SD V+ A AS + + +L +N
Sbjct: 313 AAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKEN 372
Query: 201 VKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVR 260
++P+F DE VRL + + +++ L ++P + + AED WRVR
Sbjct: 373 TIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVR 432
Query: 261 YMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCREN 320
+ + L +G E L + D +R AA++ + + + + +N
Sbjct: 433 LAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQN 492
Query: 321 VIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEV 380
I+ ++L + +D N + I LS G++ T + +LP+ L D+ V
Sbjct: 493 TIVPKVLV----MANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANV 548
Query: 381 RLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQL 434
R N+ +L + ++ L + P + +L +D V+ E + ++A +L
Sbjct: 549 RFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVVAQRL 602
>gi|4826934 protein phosphatase 4, regulatory subunit 1 isoform b
[Homo sapiens]
Length = 933
Score = 73.2 bits (178), Expect = 6e-13
Identities = 114/454 (25%), Positives = 183/454 (40%), Gaps = 51/454 (11%)
Query: 156 PRVSSAVKAELRQYFRNLCSD-DTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLAS 214
P ++ A + EL + NL D P V+ A L + LD E I + S
Sbjct: 480 PNITMATRKELEEMIENLEPHIDDPDVK-AQVEVLSAALRASSLD-AHEETISIEKR--S 535
Query: 215 DEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAV 274
D QD + + + C + QED +P + A E+ + Y+ +D +
Sbjct: 536 DLQDELDINELPNCK-----INQEDS----VPLISDAVENMDSTLHYIHSDSDLSNNSSF 586
Query: 275 GPEITKT----DLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMS---QIL 327
P+ + D+VP Q L+ + + + V A V ++ Q
Sbjct: 587 SPDEERRTKVQDVVP--QALLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQNW 644
Query: 328 PCIKE----LVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLN 383
C++E L SD V+ LA I L+ ILG T L+P+F LKD EVR+
Sbjct: 645 HCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKD-LDEVRIG 703
Query: 384 IISNLDCVNEVIGIRQLSQSLLPAIVELAED--AKWRVRLAIIEYMPLLAGQLGVEFFDE 441
++ +L +++ I + + L L D WR R + E + LL +
Sbjct: 704 VLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYD 763
Query: 442 KLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPK---------VLAMSGD 492
L + + D V ++R + + ++V+K HA P V
Sbjct: 764 YLRPIALNLCADKVSSVRWISYKLVSEMVKKL-----HAATPPTFGVDLINELVENFGRC 818
Query: 493 PNYLHRMTTLF-CINVLSEVC-GQDITTKHMLPTVLRMAGDPVANVRFNVAKS-----LQ 545
P + R +F C V+ + C D H++P +L +A D V NVR +AK+ L+
Sbjct: 819 PKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLE 878
Query: 546 KIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFA 579
K + S Q V+ + L D+D DVKYFA
Sbjct: 879 KDYFLASASCHQEAVEQTIMALQMDRDSDVKYFA 912
Score = 55.8 bits (133), Expect = 1e-07
Identities = 41/154 (26%), Positives = 73/154 (47%), Gaps = 2/154 (1%)
Query: 322 IMSQILPCIKELVS-DANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKD-ECPE 379
+ +++ P + EL + D+N VK+ +++ ++P++GKD T +LP F D
Sbjct: 152 VETKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFH 211
Query: 380 VRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFF 439
VR +N + V+G + + LLP +L D W VR A E ++ E
Sbjct: 212 VRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIR 271
Query: 440 DEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKF 473
KL++L + + D +R+AA +L + F
Sbjct: 272 RTKLSALFINLISDPSRWVRQAAFQSLGPFISTF 305
Score = 48.9 bits (115), Expect = 1e-05
Identities = 56/232 (24%), Positives = 93/232 (40%), Gaps = 11/232 (4%)
Query: 89 LLPPLESLATVEETVVRDKAVESLRAIS---HEHSPS---DLEAHFVPLVKR-LAGGDWF 141
+L + LA E VR + +E + I+ E+ PS +P+V R LA +
Sbjct: 70 VLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQ 129
Query: 142 TSRTSACGLFSVCYPRVSSAVKAELRQ---YFRNLCSDDTPMVRRAAASKLGEFAKVLEL 198
+TS L ++ + E + D V+ A + + + A ++
Sbjct: 130 VRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGK 189
Query: 199 DNVKSEIIPMFSNLASD-EQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSW 257
D + I+P F + D VR + +I ++ Q+ E +++P Q D W
Sbjct: 190 DITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVW 249
Query: 258 RVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEF 309
VR A+ F + A EI +T L F NL+ D VR AA + F
Sbjct: 250 GVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPF 301
Score = 37.7 bits (86), Expect = 0.030
Identities = 47/224 (20%), Positives = 84/224 (37%), Gaps = 15/224 (6%)
Query: 367 PLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEY 426
P A+L ++ P + L N + S+ LLP +V D +VR
Sbjct: 83 PTVRAELMEQVPHIALFCQENRPSIPYAF-----SKFLLPIVVRYLADQNNQVRKTSQAA 137
Query: 427 MPLLAGQLGVEFFDEKLNSLCMAWLV----DHVYAIREAATSNLKKLVEKFGKEWAHATI 482
+ L Q +E FD + +C + D ++ A + + K+ GK+ I
Sbjct: 138 LLALLEQELIERFDVE-TKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLI 196
Query: 483 IPKVLAMSGDPNYLHRMTTLFCINVLSEVC---GQDITTKHMLPTVLRMAGDPVANVRFN 539
+P+ M D H C ++C GQ T + +LP ++ D V VR
Sbjct: 197 LPRFCEMCCDCRMFH--VRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKA 254
Query: 540 VAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEAL 583
A+ + ++++ + L D V+ A ++L
Sbjct: 255 CAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSL 298
Score = 37.0 bits (84), Expect = 0.051
Identities = 46/255 (18%), Positives = 98/255 (38%), Gaps = 13/255 (5%)
Query: 307 KEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTI---- 362
+ + L C + +L I L D+ V++ L + ++ ++
Sbjct: 51 RSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYA 110
Query: 363 --EHLLPLFLAQLKDECPEVRLNIISNLDCV--NEVIGIRQLSQSLLPAIVEL-AEDAKW 417
+ LLP+ + L D+ +VR + L + E+I + + P ++EL A D+
Sbjct: 111 FSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSND 170
Query: 418 RVRLAIIEYMPLLAGQLGVEFFDEK-LNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKE 476
V+ + M +A +G + + L C ++ +R+ +N + G++
Sbjct: 171 DVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQ 230
Query: 477 WAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANV 536
++P+ + D + R C +S Q+I + + + DP V
Sbjct: 231 ATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWV 290
Query: 537 RFNVAKSLQKIGPIL 551
R + Q +GP +
Sbjct: 291 R---QAAFQSLGPFI 302
Score = 33.1 bits (74), Expect = 0.73
Identities = 52/252 (20%), Positives = 97/252 (38%), Gaps = 13/252 (5%)
Query: 38 IALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLA 97
+A+ LG + T ++L+P + D DEV + + + L F L+ + L E L
Sbjct: 673 LAVILGDQLTAADLVPIFNGFLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLV 732
Query: 98 TVEETVVRDKA--VESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCY 155
T R +A E L + +SP D+ + P+ L + R + L S
Sbjct: 733 TDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMV 792
Query: 156 PRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFA-------KVLELDNVKSEIIPM 208
++ +A N ++ + + + F L +D ++P
Sbjct: 793 KKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPH 852
Query: 209 FSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFT 268
LA+D +VR+L + + Q L ++D L + Q A +++ M D
Sbjct: 853 LLTLANDRVPNVRVLLAK---TLRQTLLEKDY-FLASASCHQEAVEQTIMALQMDRDSDV 908
Query: 269 ELQKAVGPEITK 280
+ ++ P TK
Sbjct: 909 KYFASIHPASTK 920
>gi|108936953 protein phosphatase 4, regulatory subunit 1 isoform a
[Homo sapiens]
Length = 950
Score = 73.2 bits (178), Expect = 6e-13
Identities = 114/454 (25%), Positives = 183/454 (40%), Gaps = 51/454 (11%)
Query: 156 PRVSSAVKAELRQYFRNLCSD-DTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLAS 214
P ++ A + EL + NL D P V+ A L + LD E I + S
Sbjct: 497 PNITMATRKELEEMIENLEPHIDDPDVK-AQVEVLSAALRASSLD-AHEETISIEKR--S 552
Query: 215 DEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAV 274
D QD + + + C + QED +P + A E+ + Y+ +D +
Sbjct: 553 DLQDELDINELPNCK-----INQEDS----VPLISDAVENMDSTLHYIHSDSDLSNNSSF 603
Query: 275 GPEITKT----DLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMS---QIL 327
P+ + D+VP Q L+ + + + V A V ++ Q
Sbjct: 604 SPDEERRTKVQDVVP--QALLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQNW 661
Query: 328 PCIKE----LVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLN 383
C++E L SD V+ LA I L+ ILG T L+P+F LKD EVR+
Sbjct: 662 HCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKD-LDEVRIG 720
Query: 384 IISNLDCVNEVIGIRQLSQSLLPAIVELAED--AKWRVRLAIIEYMPLLAGQLGVEFFDE 441
++ +L +++ I + + L L D WR R + E + LL +
Sbjct: 721 VLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYD 780
Query: 442 KLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPK---------VLAMSGD 492
L + + D V ++R + + ++V+K HA P V
Sbjct: 781 YLRPIALNLCADKVSSVRWISYKLVSEMVKKL-----HAATPPTFGVDLINELVENFGRC 835
Query: 493 PNYLHRMTTLF-CINVLSEVC-GQDITTKHMLPTVLRMAGDPVANVRFNVAKS-----LQ 545
P + R +F C V+ + C D H++P +L +A D V NVR +AK+ L+
Sbjct: 836 PKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLE 895
Query: 546 KIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFA 579
K + S Q V+ + L D+D DVKYFA
Sbjct: 896 KDYFLASASCHQEAVEQTIMALQMDRDSDVKYFA 929
Score = 55.8 bits (133), Expect = 1e-07
Identities = 41/154 (26%), Positives = 73/154 (47%), Gaps = 2/154 (1%)
Query: 322 IMSQILPCIKELVS-DANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKD-ECPE 379
+ +++ P + EL + D+N VK+ +++ ++P++GKD T +LP F D
Sbjct: 169 VETKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFH 228
Query: 380 VRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFF 439
VR +N + V+G + + LLP +L D W VR A E ++ E
Sbjct: 229 VRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIR 288
Query: 440 DEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKF 473
KL++L + + D +R+AA +L + F
Sbjct: 289 RTKLSALFINLISDPSRWVRQAAFQSLGPFISTF 322
Score = 48.9 bits (115), Expect = 1e-05
Identities = 56/232 (24%), Positives = 93/232 (40%), Gaps = 11/232 (4%)
Query: 89 LLPPLESLATVEETVVRDKAVESLRAIS---HEHSPS---DLEAHFVPLVKR-LAGGDWF 141
+L + LA E VR + +E + I+ E+ PS +P+V R LA +
Sbjct: 87 VLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQ 146
Query: 142 TSRTSACGLFSVCYPRVSSAVKAELRQ---YFRNLCSDDTPMVRRAAASKLGEFAKVLEL 198
+TS L ++ + E + D V+ A + + + A ++
Sbjct: 147 VRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGK 206
Query: 199 DNVKSEIIPMFSNLASD-EQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSW 257
D + I+P F + D VR + +I ++ Q+ E +++P Q D W
Sbjct: 207 DITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVW 266
Query: 258 RVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEF 309
VR A+ F + A EI +T L F NL+ D VR AA + F
Sbjct: 267 GVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPF 318
Score = 37.7 bits (86), Expect = 0.030
Identities = 47/224 (20%), Positives = 84/224 (37%), Gaps = 15/224 (6%)
Query: 367 PLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEY 426
P A+L ++ P + L N + S+ LLP +V D +VR
Sbjct: 100 PTVRAELMEQVPHIALFCQENRPSIPYAF-----SKFLLPIVVRYLADQNNQVRKTSQAA 154
Query: 427 MPLLAGQLGVEFFDEKLNSLCMAWLV----DHVYAIREAATSNLKKLVEKFGKEWAHATI 482
+ L Q +E FD + +C + D ++ A + + K+ GK+ I
Sbjct: 155 LLALLEQELIERFDVE-TKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLI 213
Query: 483 IPKVLAMSGDPNYLHRMTTLFCINVLSEVC---GQDITTKHMLPTVLRMAGDPVANVRFN 539
+P+ M D H C ++C GQ T + +LP ++ D V VR
Sbjct: 214 LPRFCEMCCDCRMFH--VRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKA 271
Query: 540 VAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEAL 583
A+ + ++++ + L D V+ A ++L
Sbjct: 272 CAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSL 315
Score = 37.0 bits (84), Expect = 0.051
Identities = 46/255 (18%), Positives = 98/255 (38%), Gaps = 13/255 (5%)
Query: 307 KEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTI---- 362
+ + L C + +L I L D+ V++ L + ++ ++
Sbjct: 68 RSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYA 127
Query: 363 --EHLLPLFLAQLKDECPEVRLNIISNLDCV--NEVIGIRQLSQSLLPAIVEL-AEDAKW 417
+ LLP+ + L D+ +VR + L + E+I + + P ++EL A D+
Sbjct: 128 FSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSND 187
Query: 418 RVRLAIIEYMPLLAGQLGVEFFDEK-LNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKE 476
V+ + M +A +G + + L C ++ +R+ +N + G++
Sbjct: 188 DVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQ 247
Query: 477 WAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANV 536
++P+ + D + R C +S Q+I + + + DP V
Sbjct: 248 ATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWV 307
Query: 537 RFNVAKSLQKIGPIL 551
R + Q +GP +
Sbjct: 308 R---QAAFQSLGPFI 319
Score = 33.1 bits (74), Expect = 0.73
Identities = 52/252 (20%), Positives = 97/252 (38%), Gaps = 13/252 (5%)
Query: 38 IALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLA 97
+A+ LG + T ++L+P + D DEV + + + L F L+ + L E L
Sbjct: 690 LAVILGDQLTAADLVPIFNGFLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLV 749
Query: 98 TVEETVVRDKA--VESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCY 155
T R +A E L + +SP D+ + P+ L + R + L S
Sbjct: 750 TDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMV 809
Query: 156 PRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFA-------KVLELDNVKSEIIPM 208
++ +A N ++ + + + F L +D ++P
Sbjct: 810 KKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPH 869
Query: 209 FSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFT 268
LA+D +VR+L + + Q L ++D L + Q A +++ M D
Sbjct: 870 LLTLANDRVPNVRVLLAK---TLRQTLLEKDY-FLASASCHQEAVEQTIMALQMDRDSDV 925
Query: 269 ELQKAVGPEITK 280
+ ++ P TK
Sbjct: 926 KYFASIHPASTK 937
>gi|17402886 HEAT-like repeat-containing protein isoform 1 [Homo
sapiens]
Length = 873
Score = 70.9 bits (172), Expect = 3e-12
Identities = 110/552 (19%), Positives = 213/552 (38%), Gaps = 54/552 (9%)
Query: 85 YVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFV--PLVKRLAGGDWFT 142
Y H L + +T V + +E+L ++ E P + H + PLV +
Sbjct: 130 YTHSFLQVILLHLEHRDTGVSNAWLETLLSVI-EVLPKETLRHEILNPLVSKAQLSQTVQ 188
Query: 143 SRTSACGLFSVCYPRVSS-AVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNV 201
SR +C + + + +K E+ ++LC D VR +L A+ + +
Sbjct: 189 SRLVSCKILGKLTNKFDAHTIKREILPLVKSLCQDVEYEVRSCMCRQLENIAQGIGTELT 248
Query: 202 KSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWR--- 258
KS ++P L+ DE SVRL A E VN+ + +D ++P ++ E KS++
Sbjct: 249 KSVVLPELIELSRDEGSSVRLAAFETLVNLLDIFDTDDRSQTILPLVKSFCE-KSFKADE 307
Query: 259 -VRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADC 317
+ ++ +L + T + + K C ++ H + +
Sbjct: 308 SILISLSFHLGKLCHGLYGIFTPDQHLRFLEFYKKLCTLGLQQENGHNENQIPPQILEQE 367
Query: 318 RENVIM----SQILPCIKELVSDANQH-----------------VKSALASVIMGLSPIL 356
++ + + + P + V N H V+ +A +S +L
Sbjct: 368 KKYISVRKNCAYNFPAMIVFVDPKNFHMELYSTFFCLCHDPEVPVRYTIAICFYEVSKLL 427
Query: 357 GKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVI------GIRQLSQSLLPAIV- 409
+ H + L+DE EV +I +L + E++ +++ S LP ++
Sbjct: 428 NSGVYLIH--KELITLLQDESLEVLDALIDHLPEILELMSTGGESSVQENKLSSLPDLIP 485
Query: 410 -------ELAEDAKWRVRLAIIEYMPLLAGQLGV-EFFDEKLNSLCMAWLVDHVYAIREA 461
A KWR +++ L + + + L + + ++V +++A
Sbjct: 486 ALTAAEQRAAASLKWRTHEKLLQKYACLPHVISSDQIYYRFLQRMFTIMMTNNVLPVQKA 545
Query: 462 ATSNLKKLVEKFGKEWAHATIIPKVLAMSGD-PNYLHRMTTLFCINVLSEVCGQDITTKH 520
A+ L + K+ +I K++ G +Y +R+ L + E+ + K+
Sbjct: 546 ASRTLCIFLRYNRKQEQRHEVIQKLIEQLGQGKSYWNRLRFLDTCEFIIEIFSKSFFCKY 605
Query: 521 MLPTVLRMAGDPVANVRFNVAKSLQKIGPIL----DNSTLQSEVKPILEKLTQDQDVDVK 576
+ + DPVANVR + L K+ L D LQ + + L Q++D DV
Sbjct: 606 FFLPAIELTHDPVANVRMKLCYLLPKVKSTLKIPADKHLLQQLEMCVRKLLCQEKDKDVL 665
Query: 577 YFAQEALTVLSL 588
+ TVL L
Sbjct: 666 AIVKR--TVLEL 675
Score = 39.7 bits (91), Expect = 0.008
Identities = 51/229 (22%), Positives = 91/229 (39%), Gaps = 7/229 (3%)
Query: 347 SVIMGLSPILGKDN---TIEHLLPLFLAQLKDECPEVRLNIISNLDCV--NEVIGIRQLS 401
SVI L P L + N T+ +LP L E++L + + +E + I +
Sbjct: 73 SVIANL-PFLMRQNPTETLRRVLPKVREALHVAGVEMQLTAAMSFLTILQDESVSIHAYT 131
Query: 402 QSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFF-DEKLNSLCMAWLVDHVYAIRE 460
S L I+ E V A +E + + L E E LN L + R
Sbjct: 132 HSFLQVILLHLEHRDTGVSNAWLETLLSVIEVLPKETLRHEILNPLVSKAQLSQTVQSRL 191
Query: 461 AATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKH 520
+ L KL KF I+P V ++ D Y R + +++ G ++T
Sbjct: 192 VSCKILGKLTNKFDAHTIKREILPLVKSLCQDVEYEVRSCMCRQLENIAQGIGTELTKSV 251
Query: 521 MLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQ 569
+LP ++ ++ D ++VR ++L + I D + P+++ +
Sbjct: 252 VLPELIELSRDEGSSVRLAAFETLVNLLDIFDTDDRSQTILPLVKSFCE 300
Score = 30.0 bits (66), Expect = 6.2
Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 5/90 (5%)
Query: 23 EDVQLRLNSI--KKLSTIALALGVERTRSELLPFLTDTIYDE-DEVLLALAEQLGTFTTL 79
+DV+ + S ++L IA +G E T+S +LP L + DE V LA E L +
Sbjct: 222 QDVEYEVRSCMCRQLENIAQGIGTELTKSVVLPELIELSRDEGSSVRLAAFETLVNLLDI 281
Query: 80 VGGPEYVHCLLPPLESLATVEETVVRDKAV 109
+ +LP ++S E++ D+++
Sbjct: 282 FDTDDRSQTILPLVKSFC--EKSFKADESI 309
>gi|54607053 GCN1 general control of amino-acid synthesis 1-like 1
[Homo sapiens]
Length = 2671
Score = 53.5 bits (127), Expect = 5e-07
Identities = 124/590 (21%), Positives = 217/590 (36%), Gaps = 62/590 (10%)
Query: 35 LSTIALALGV-ERTRSELLPFLTDTIYDED-----EVLLALAEQLGTFTTLVGGPEYVHC 88
L+ + LG+ + E++ LTD I D+ E L E L T + P VH
Sbjct: 1401 LAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALFAFEMLCTMLGKLFEPYVVH- 1459
Query: 89 LLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSA- 147
+LP L VR+ A + +A+ S ++ L+ L W T S
Sbjct: 1460 VLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVE 1519
Query: 148 -CGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEII 206
G + C P+ S+ + + +D V++A L + V+ + +
Sbjct: 1520 LLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVIRNPEILAIAP 1579
Query: 207 PMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADK 266
+ L + + + L + L AL+MP +++A +D+S R M A
Sbjct: 1580 VLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSL-ALIMPIVQRAFQDRSTDTRKMAAQI 1638
Query: 267 FTEL-----QKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENV 321
+ QK + P + + P + + D EVR ++ + + + C E++
Sbjct: 1639 IGNMYSLTDQKDLAPYL--PSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCFEDL 1696
Query: 322 IMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLK--DECPE 379
+ + E S LA V+ GL +E L+P +A D P
Sbjct: 1697 LPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGV-----EKLEKLMPEIVATASKVDIAPH 1751
Query: 380 VRLNIISNLDCVNEVIG------IRQLSQSLLPAIV---ELAEDAKWRVRLAIIEY---- 426
VR I + + G + + +L A+ E D R +I
Sbjct: 1752 VRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRAGQRVISMYAET 1811
Query: 427 -MPLLAGQLGVEFFDE----KLNSL-CMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHA 480
+ LL QL FD+ + +S+ + L+ H+ + T+ + FG ++
Sbjct: 1812 AIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASEDDNFGTAQSNK 1871
Query: 481 TIIP--------KVLA----MSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPT---- 524
II +VLA D + R +L ++ V T + +LPT
Sbjct: 1872 AIITALGVERRNRVLAGLYMGRSDTQLVVRQASLHVWKIV--VSNTPRTLREILPTLFGL 1929
Query: 525 VLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVD 574
+L A+ R A++L + L L E+ PILE+ + Q D
Sbjct: 1930 LLGFLASTCADKRTIAARTLGDLVRKLGEKIL-PEIIPILEEGLRSQKSD 1978
Score = 48.1 bits (113), Expect = 2e-05
Identities = 76/351 (21%), Positives = 131/351 (37%), Gaps = 54/351 (15%)
Query: 205 IIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRY--- 261
IIP +DE + VR A+ A + + + + AL++P L Q D WR+R+
Sbjct: 1778 IIPCILKALADENEFVRDTALRAGQRVISMYAETAI-ALLLPQLEQGLFDDLWRIRFSSV 1836
Query: 262 -MVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCREN 320
++ D + G T+T + + K L + R
Sbjct: 1837 QLLGDLLFHISGVTGKMTTET------------ASEDDNFGTAQSNKAIITALGVERRNR 1884
Query: 321 VIMSQIL--PCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLP----LFLAQLK 374
V+ + + +V A+ HV + S T+ +LP L L L
Sbjct: 1885 VLAGLYMGRSDTQLVVRQASLHVWKIVVS---------NTPRTLREILPTLFGLLLGFLA 1935
Query: 375 DECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAE--------DAKWRVRLAIIEY 426
C + R L + +R+L + +LP I+ + E D + V + + E
Sbjct: 1936 STCADKRTIAARTLGDL-----VRKLGEKILPEIIPILEEGLRSQKSDERQGVCIGLSEI 1990
Query: 427 MPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKV 486
M + V +F E L L D + +REAA ++L G + A I+P +
Sbjct: 1991 MKSTSRD-AVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQ-ALEDILPFL 2048
Query: 487 LAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVR 537
L D + F ++ L +V I ++ +LP ++ P N R
Sbjct: 2049 LKQLDDEE-----VSEFALDGLKQVMA--IKSRVVLPYLVPKLTTPPVNTR 2092
>gi|54112117 splicing factor 3b, subunit 1 isoform 1 [Homo sapiens]
Length = 1304
Score = 50.1 bits (118), Expect = 6e-06
Identities = 131/633 (20%), Positives = 253/633 (39%), Gaps = 102/633 (16%)
Query: 13 IAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFL-----TDTIYDEDEVLL 67
I+ + ++ N D +R + + + +A ALG+ LLPFL + + +
Sbjct: 610 ISTMRPDIDNMDEYVRNTTARAFAVVASALGIP----SLLPFLKAVCKSKKSWQARHTGI 665
Query: 68 ALAEQLGTFTTLVGGPEYVHCLLPPLESLATV-------EETVVRDKAVESLRAISHEHS 120
+ +Q+ L+G +LP L SL + E+ VR + ++ A++ +
Sbjct: 666 KIVQQIAI---LMGC-----AILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAAT 717
Query: 121 PSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYF---------R 171
P +E+ L G + A L ++ Y + + AE Y+ R
Sbjct: 718 PYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGY--LIPLMDAEYANYYTREVMLILIR 775
Query: 172 NLCSDDTPM---VRRAAASKLGEFAKVLELDNVKSEIIPMF------SNLASDEQDSVRL 222
S D M V + G +E + +K+EI+P F +A D ++ +L
Sbjct: 776 EFQSPDEEMKKIVLKVVKQCCGTDG--VEANYIKTEILPPFFKHFWQHRMALDRRNYRQL 833
Query: 223 LAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGP------ 276
V+ V +A + ++ + ++ L+ AE + R MV + ++ +G
Sbjct: 834 --VDTTVELANKVGAAEIISRIVDDLKDEAE----QYRKMVMETIEKIMGNLGAADIDHK 887
Query: 277 --EITKTDLVPAFQ------NLMKDCEAEVRAAASHKVKEFCENLSADC--RENVIMSQI 326
E ++ AFQ ++M + V A +VK + + R N +++
Sbjct: 888 LEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKV 947
Query: 327 LPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIIS 386
+L+S +K+ +MG HL + L +E PEV +I+
Sbjct: 948 RQQAADLISRTAVVMKTCQEEKLMG------------HLGVVLYEYLGEEYPEVLGSILG 995
Query: 387 NLDCVNEVIGIRQLS---QSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFD-EK 442
L + VIG+ +++ + LLP + + ++ +V+ I+ + +A + G E+ +
Sbjct: 996 ALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADR-GAEYVSARE 1054
Query: 443 LNSLC---MAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRM 499
+C + L H AIR A + + + G AT++ + +R+
Sbjct: 1055 WMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQ----NRV 1110
Query: 500 TTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSL----QKIGPILDNST 555
T I +++E C + +LP ++ P NV+ V KSL + IG +
Sbjct: 1111 CTTVAIAIVAETC----SPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEM--GKD 1164
Query: 556 LQSEVKPILEKLTQDQDVDVKYFAQEALTVLSL 588
V P+LE D+D+ + A + +SL
Sbjct: 1165 YIYAVTPLLEDALMDRDLVHRQTASAVVQHMSL 1197
>gi|23943912 phosphoinositide-3-kinase, regulatory subunit 4 [Homo
sapiens]
Length = 1358
Score = 41.2 bits (95), Expect = 0.003
Identities = 39/150 (26%), Positives = 65/150 (43%), Gaps = 13/150 (8%)
Query: 290 LMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASV- 348
+ KD + H + E E + +++S I C++ L ++ S LA++
Sbjct: 346 IRKDLGNIIHNLCGHDLPEKAEGEPKENGLVILVSVITSCLQTL-----KYCDSKLAALE 400
Query: 349 -IMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVI------GIRQLS 401
I+ L+P L + ++ + P L D P VR + L V ++ I
Sbjct: 401 LILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYP 460
Query: 402 QSLLPAIVELAEDAKWRVRLAIIEYMPLLA 431
+ +LP I LA+D VRLA E + LLA
Sbjct: 461 EYILPGIAHLAQDDATIVRLAYAENIALLA 490
Score = 31.2 bits (69), Expect = 2.8
Identities = 70/287 (24%), Positives = 121/287 (42%), Gaps = 36/287 (12%)
Query: 143 SRTSACGLFSVCYPRVSSAVKAE-LRQYFRNLCSDDTPMVRRAAASKLGE-FAKVLELD- 199
S+ +A L PR+S + + + Y + +D P VR A L + A V E+
Sbjct: 394 SKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVKEVPR 453
Query: 200 ---NVKSE-IIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLR------ 249
N+ E I+P ++LA D+ VRL E NIA LL + L L + L+
Sbjct: 454 NDINIYPEYILPGIAHLAQDDATIVRLAYAE---NIA-LLAETALRFLELVQLKNLNMEN 509
Query: 250 QAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVR-AAASHKVKE 308
++ V + + TELQ E+ + +V L+ D E V+ + +
Sbjct: 510 DPNNEEIDEVTHPNGNYDTELQAL--HEMVQQKVV----TLLSDPENIVKQTLMENGITR 563
Query: 309 FCENLSADCRENVIMSQILPCIKELVSDANQ-HVKSALASVIMGLSPILGKDNTIEHLLP 367
C +V++S ++ ++D N H++ A I+G++ +G ++ L P
Sbjct: 564 LCVFFGRQKANDVLLSHMI----TFLNDKNDWHLRGAFFDSIVGVAAYVGWQSS-SILKP 618
Query: 368 LFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAED 414
L L D V + + L C+ + +G+ Q P + E A D
Sbjct: 619 LLQQGLSDAEEFVIVKALYALTCMCQ-LGLLQ-----KPHVYEFASD 659
>gi|19923142 karyopherin beta 1 [Homo sapiens]
Length = 876
Score = 41.2 bits (95), Expect = 0.003
Identities = 37/181 (20%), Positives = 75/181 (41%), Gaps = 13/181 (7%)
Query: 168 QYFRNLCSDDTPMVRRAA-ASKLG---EFAKVLELDNVKSEIIPMFSNLAS------DEQ 217
+++ N+C ++ + A+ A++ G E ++P+ + + D+
Sbjct: 281 EFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDD 340
Query: 218 DSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPE 277
D A C+ + ++D+ V+P +++ ++ WR R F + + P
Sbjct: 341 DWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPS 400
Query: 278 ITKTDLV---PAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELV 334
K ++ P LMKD VR A+ V CE L +V ++ +L C+ E +
Sbjct: 401 QLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGL 460
Query: 335 S 335
S
Sbjct: 461 S 461
>gi|241982712 TBP-interacting protein isoform 1 [Homo sapiens]
Length = 1236
Score = 37.4 bits (85), Expect = 0.039
Identities = 93/471 (19%), Positives = 170/471 (36%), Gaps = 84/471 (17%)
Query: 6 GDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIA---LALGVERTRSELLPFLTDTIYDE 62
GDD + +L+D LRNE RL +IK L+ +A L L ++ +E L L +
Sbjct: 607 GDDLEPTLLLLLDRLRNEIT--RLPAIKALTLVAVSPLQLDLQPILAEALHILASFLRKN 664
Query: 63 DEVL----LALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHE 118
L LA + L L P V +L L +L + V AV+ L ++
Sbjct: 665 QRALRLATLAALDALAQSQGLSLPPSAVQAVLAELPALVNESDMHVAQLAVDFLATVTQA 724
Query: 119 HSPSDLE------AHFVPLVKR-------LAGGDWFTSRTSACGLFSVCYPRVSSAVKAE 165
S +E + + L++ LA + F V Y ++ S + A
Sbjct: 725 QPASLVEVSGPVLSELLRLLRSPLLPAGVLAAAEGFLQALVGTRPPCVDYAKLISLLTAP 784
Query: 166 LRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQD-----SV 220
+ + D P + + L L E S L D + V
Sbjct: 785 VYEQ----AVDGGPGLHKQVFHSLARCVAALSA-ACPQEAASTASRLVCDARSPHSSTGV 839
Query: 221 RLLAVEACVNIAQLL---PQEDLEALVMPTLRQAAED----------------------- 254
++LA + + Q+ Q +L+A+++ L +ED
Sbjct: 840 KVLAFLSLAEVGQVAGPGHQRELKAVLLEALGSPSEDVRAAASYALGRVGAGSLPDFLPF 899
Query: 255 ------KSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKE 308
R +Y++ E A P+ K + L + CE +E
Sbjct: 900 LLEQIEAEPRRQYLLLHSLREALGAAQPDSLKPYAEDIWALLFQRCEG---------AEE 950
Query: 309 FCENLSADCRENVIM---SQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHL 365
+ A+C +++ S +LP +++ ++ H +S + + + L I + + I+ L
Sbjct: 951 GTRGVVAECIGKLVLVNPSFLLPRLRKQLAAGRPHTRSTVITAVKFL--ISDQPHPIDPL 1008
Query: 366 LPLFLAQLKDECPEVRLNI------ISNLDCVNEVIGIRQLSQSLLPAIVE 410
L F+ + + + LN+ N N+ +R L +LP + +
Sbjct: 1009 LKSFIGEFMESLQDPDLNVRRATLAFFNSAVHNKPSLVRDLLDDILPLLYQ 1059
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 36.6 bits (83), Expect = 0.066
Identities = 26/67 (38%), Positives = 37/67 (55%), Gaps = 2/67 (2%)
Query: 522 LPTVLRMAGDPVANVRFNVAKSLQKIGPI-LDNSTLQSEV-KPILEKLTQDQDVDVKYFA 579
+P++ ++ GDP A +R NVA +L +GP L LQ EV + +LE D +VK A
Sbjct: 1194 VPSMTQLLGDPQAGIRRNVASALGNLGPEGLGEELLQCEVPQRLLEMACGDPQPNVKEAA 1253
Query: 580 QEALTVL 586
AL L
Sbjct: 1254 LIALRSL 1260
>gi|90903231 huntingtin [Homo sapiens]
Length = 3144
Score = 35.8 bits (81), Expect = 0.11
Identities = 49/218 (22%), Positives = 88/218 (40%), Gaps = 39/218 (17%)
Query: 191 EFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQ 250
EF K+L + + +F + D + VR++A E + + L +L L + ++
Sbjct: 122 EFQKLLGI------AMELFLLCSDDAESDVRMVADECLNKVIKALMDSNLPRLQLELYKE 175
Query: 251 AAEDKSWRVRYMVADKFTELQKAVGPEITK---TDLVPAFQNLMKDCEAEVR---AAASH 304
++ + R +F EL V P+ + +L+P K E V+ AAA
Sbjct: 176 IKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVP 235
Query: 305 KVKEFCENLSADCRENVIMSQIL-------PCIKELVSDA----------NQHVKSALAS 347
K+ N + D V++ + P I+ + + Q+ S L +
Sbjct: 236 KIMASFGNFANDNEIKVLLKAFIANLKSSSPTIRRTAAGSAVSICQHSRRTQYFYSWLLN 295
Query: 348 VIMGLSP----------ILGKDNTIEHLLPLFLAQLKD 375
V++GL ILG T+ +L+PL Q+KD
Sbjct: 296 VLLGLLVPVEDEHSTLLILGVLLTLRYLVPLLQQQVKD 333
>gi|23510381 transportin 1 isoform 2 [Homo sapiens]
Length = 890
Score = 35.8 bits (81), Expect = 0.11
Identities = 73/376 (19%), Positives = 137/376 (36%), Gaps = 58/376 (15%)
Query: 98 TVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLA-GGDWFTSRTSACGLFSVCYP 156
T+ + +R + +L +++ + +L H +PL+K L +W + L ++
Sbjct: 369 TISDWNLRKCSAAALDVLANVYR-DELLPHILPLLKELLFHHEWVVKESGILVLGAIAEG 427
Query: 157 RVSSAVK--AELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLAS 214
+ + EL + SD +VR L +A + + + P+ + L
Sbjct: 428 CMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLK 487
Query: 215 DEQDSVRLLAVEACVNIAQLLPQEDLE-----ALVMPTLRQAAEDKSWRVRYMVADKFTE 269
DS + + AC A L + E A ++ TL A + ++ D
Sbjct: 488 RILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGT 547
Query: 270 LQKAVGPEITKTDLV-----PAFQ--NLMKD----------CEAEVRAAASHKVKEFCEN 312
L +VG + K + + P Q N++KD C + V A +CE
Sbjct: 548 LADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEP 607
Query: 313 LSADC----RENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHL--- 365
+ C ++ + + + + ++ ++ GL+ LG IE L
Sbjct: 608 VYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLG--GNIEQLVAR 665
Query: 366 ---LPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLA 422
L L ++D+ PEVR QS + +L + V+
Sbjct: 666 SNILTLMYQCMQDKMPEVR--------------------QSSFALLGDLTKACFQHVKPC 705
Query: 423 IIEYMPLLAGQLGVEF 438
I ++MP+L L EF
Sbjct: 706 IADFMPILGTNLNPEF 721
Score = 30.0 bits (66), Expect = 6.2
Identities = 23/74 (31%), Positives = 37/74 (50%), Gaps = 12/74 (16%)
Query: 32 IKKLSTIALALGVERTRSELLPFLT---DTIYD-----EDEVLLALAEQLGTFTTLVGG- 82
+++ + A A E +EL+P+L DT+ + + LL L + +GT VG
Sbjct: 496 VQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHH 555
Query: 83 ---PEYVHCLLPPL 93
PEY+ L+PPL
Sbjct: 556 LNKPEYIQMLMPPL 569
>gi|133925811 transportin 1 isoform 1 [Homo sapiens]
Length = 898
Score = 35.8 bits (81), Expect = 0.11
Identities = 73/376 (19%), Positives = 137/376 (36%), Gaps = 58/376 (15%)
Query: 98 TVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLA-GGDWFTSRTSACGLFSVCYP 156
T+ + +R + +L +++ + +L H +PL+K L +W + L ++
Sbjct: 377 TISDWNLRKCSAAALDVLANVYR-DELLPHILPLLKELLFHHEWVVKESGILVLGAIAEG 435
Query: 157 RVSSAVK--AELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLAS 214
+ + EL + SD +VR L +A + + + P+ + L
Sbjct: 436 CMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLK 495
Query: 215 DEQDSVRLLAVEACVNIAQLLPQEDLE-----ALVMPTLRQAAEDKSWRVRYMVADKFTE 269
DS + + AC A L + E A ++ TL A + ++ D
Sbjct: 496 RILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGT 555
Query: 270 LQKAVGPEITKTDLV-----PAFQ--NLMKD----------CEAEVRAAASHKVKEFCEN 312
L +VG + K + + P Q N++KD C + V A +CE
Sbjct: 556 LADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEP 615
Query: 313 LSADC----RENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHL--- 365
+ C ++ + + + + ++ ++ GL+ LG IE L
Sbjct: 616 VYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLG--GNIEQLVAR 673
Query: 366 ---LPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLA 422
L L ++D+ PEVR QS + +L + V+
Sbjct: 674 SNILTLMYQCMQDKMPEVR--------------------QSSFALLGDLTKACFQHVKPC 713
Query: 423 IIEYMPLLAGQLGVEF 438
I ++MP+L L EF
Sbjct: 714 IADFMPILGTNLNPEF 729
Score = 30.0 bits (66), Expect = 6.2
Identities = 23/74 (31%), Positives = 37/74 (50%), Gaps = 12/74 (16%)
Query: 32 IKKLSTIALALGVERTRSELLPFLT---DTIYD-----EDEVLLALAEQLGTFTTLVGG- 82
+++ + A A E +EL+P+L DT+ + + LL L + +GT VG
Sbjct: 504 VQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHH 563
Query: 83 ---PEYVHCLLPPL 93
PEY+ L+PPL
Sbjct: 564 LNKPEYIQMLMPPL 577
>gi|157388904 HEAT repeat containing 2 [Homo sapiens]
Length = 855
Score = 35.4 bits (80), Expect = 0.15
Identities = 48/191 (25%), Positives = 77/191 (40%), Gaps = 15/191 (7%)
Query: 63 DEVLLALAEQLGTFTTLVGGPEYVH---------CLLPPLESLATVEETVVRDKAVESLR 113
+E+ LAL + LG L G H C L L+ A V A +
Sbjct: 139 EELRLALVQLLGLAVDLCGAALAPHLDDALRALRCSL--LDPFAAVRRESCSCAAALAQA 196
Query: 114 AISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNL 173
H H S E+ PL++ ++ W + +V + +V L + + L
Sbjct: 197 TPDHFHMQS--ESLIGPLMQTISHQHWKVRVAAIEATGAVIHFGNGKSVDDVLSHFAQRL 254
Query: 174 CSDDTPMVRRAAASKLGEFAKVL-ELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIA 232
DD P VRRA AS +G + L + + ++IP+ + +DE VR LA ++
Sbjct: 255 F-DDVPQVRRAVASVVGGWLLCLRDRYSFFHKLIPLLLSSLNDEVPEVRQLAASLWEDVG 313
Query: 233 QLLPQEDLEAL 243
+E+ E L
Sbjct: 314 LQWQKENEEDL 324
Score = 31.6 bits (70), Expect = 2.1
Identities = 21/60 (35%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Query: 323 MSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEH-LLPLFLAQLKDECPEVR 381
+ +L + + D V+ A+ASV+ G L + H L+PL L+ L DE PEVR
Sbjct: 243 VDDVLSHFAQRLFDDVPQVRRAVASVVGGWLLCLRDRYSFFHKLIPLLLSSLNDEVPEVR 302
>gi|109948292 hypothetical protein LOC57614 [Homo sapiens]
Length = 1216
Score = 35.0 bits (79), Expect = 0.19
Identities = 24/73 (32%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Query: 192 FAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQ- 250
FA+ + V++E++P + + RLL E+C +A LP+E +LV+ L+Q
Sbjct: 588 FARHVGPTRVEAELLPQCWEQINHKYPERRLLVAESCGALAPYLPKEIRSSLVLSMLQQM 647
Query: 251 AAEDKSWRVRYMV 263
EDK+ VR V
Sbjct: 648 LMEDKADLVREAV 660
Score = 29.6 bits (65), Expect = 8.1
Identities = 19/76 (25%), Positives = 34/76 (44%)
Query: 201 VKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVR 260
V + P L+SD + SVR+ + A I + + Q +L V L ED ++ +
Sbjct: 1000 VDKRVAPALVTLSSDPEFSVRIATIPAFGTIMETVIQRELLERVKMQLASFLEDPQYQDQ 1059
Query: 261 YMVADKFTELQKAVGP 276
+ + + + VGP
Sbjct: 1060 HSLHTEIIKTFGRVGP 1075
>gi|112420977 TBP-interacting protein isoform 2 [Homo sapiens]
Length = 1119
Score = 34.3 bits (77), Expect = 0.33
Identities = 36/127 (28%), Positives = 54/127 (42%), Gaps = 9/127 (7%)
Query: 6 GDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIA---LALGVERTRSELLPFLTDTIYDE 62
GDD + +L+D LRNE RL +IK L+ +A L L ++ +E L L +
Sbjct: 514 GDDLEPTLLLLLDRLRNEIT--RLPAIKALTLVAVSPLQLDLQPILAEALHILASFLRKN 571
Query: 63 DEVL----LALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHE 118
L LA + L L P V +L L +L + V AV+ L ++
Sbjct: 572 QRALRLATLAALDALAQSQGLSLPPSAVQAVLAELPALVNESDMHVAQLAVDFLATVTQA 631
Query: 119 HSPSDLE 125
S +E
Sbjct: 632 QPASLVE 638
>gi|93102424 hypothetical protein LOC23116 [Homo sapiens]
Length = 1720
Score = 34.3 bits (77), Expect = 0.33
Identities = 39/190 (20%), Positives = 77/190 (40%), Gaps = 15/190 (7%)
Query: 253 EDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCEN 312
+ + ++ R ++ ++ P T + F +L+ + + H E
Sbjct: 361 DQEDYKNRTQAVEELKQVLGKFNPSSTPHSSLVGFISLLYNLLDDSNFKVVHGTLEVLHL 420
Query: 313 LSADCRENV--IMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFL 370
L E V + ++ ++++D +K + + L +G + +L L L
Sbjct: 421 LVIRLGEQVQQFLGPVIAASVKVLADNKLVIKQEYMKIFLKLMKEVGP----QQVLCLLL 476
Query: 371 AQLKDECPEVRLNIISNLDCV-----NEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIE 425
LK + VR +++ C +E + +LS L PA+V D+K RVR A +E
Sbjct: 477 EHLKHKHSRVREEVVNICICSLLTYPSEDFDLPKLSFDLAPALV----DSKRRVRQAALE 532
Query: 426 YMPLLAGQLG 435
+LA +G
Sbjct: 533 AFAVLASSMG 542
>gi|18034767 phosphorylated CTD interacting factor 1 [Homo sapiens]
Length = 704
Score = 34.3 bits (77), Expect = 0.33
Identities = 54/241 (22%), Positives = 100/241 (41%), Gaps = 35/241 (14%)
Query: 165 ELRQYFRNLCSD----DTP-------MVRRAAASKLGEFAKVLELDNVKSEIIP-MFSNL 212
+LRQ++R LC + P M+ R K + L N + + P MF +
Sbjct: 211 KLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGSD---PLLPSNCEPVVSPSMFREI 267
Query: 213 ASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQK 272
+D +RL ++ +LL + A + R A+ D V++ V D F+ L+K
Sbjct: 268 MNDIP--IRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRK 325
Query: 273 AVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENV--IMSQILPCI 330
+K D + ++L + C V AAA V+ C + E V I + L +
Sbjct: 326 --DHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAIL 383
Query: 331 KELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDC 390
KE ++ ++ V++ + + + P+ LA P V +++ +N+ C
Sbjct: 384 KE--NNISEEVEAPEV------------EPRLVYCYPVRLAVSAPPMPSVEMHMENNVVC 429
Query: 391 V 391
+
Sbjct: 430 I 430
>gi|62460637 importin 4 [Homo sapiens]
Length = 1081
Score = 33.9 bits (76), Expect = 0.43
Identities = 55/211 (26%), Positives = 85/211 (40%), Gaps = 24/211 (11%)
Query: 224 AVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDL 283
AV+ +A LP E L +MP L +A +S R L G I + L
Sbjct: 333 AVQVVDMLALHLPPEKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLL 392
Query: 284 VPAFQNLMK---DCEAEVRAAASHKVKEFCENL----SADCRENVIMSQILPCIKELVSD 336
P Q + K D VR AA + +F ENL S+ RE +M +L +K +
Sbjct: 393 PPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSRE--VMPLLLAYLKSVPLG 450
Query: 337 ANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIG 396
H+ A ++ +N +E+L P L E E L ++ N
Sbjct: 451 HTHHLAKACYAL----------ENFVENLGPKVQPYL-PELMECMLQLLRNPSSPR---- 495
Query: 397 IRQLSQSLLPAIVELAEDAKWRVRLAIIEYM 427
++L+ S L AI A+ + AI+E++
Sbjct: 496 AKELAVSALGAIATAAQASLLPYFPAIMEHL 526
>gi|50086624 integrator complex subunit 4 [Homo sapiens]
Length = 963
Score = 33.9 bits (76), Expect = 0.43
Identities = 60/275 (21%), Positives = 101/275 (36%), Gaps = 30/275 (10%)
Query: 175 SDDTPMVRRAAASKLGEF-AKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQ 233
SD P VR AA + + + L+L I L SD+ + VR AV+ ++Q
Sbjct: 205 SDQDPRVRTAAIKAMLQLHERGLKLHQT---IYNQACKLLSDDYEQVRSAAVQLIWVVSQ 261
Query: 234 LLPQ---------EDLEAL--VMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTD 282
L P+ E++ + + D SW VR A +++ + +T
Sbjct: 262 LYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRVQAAKLLGSMEQVSSHFLEQTL 321
Query: 283 LVPAFQNLMKDCEAEVRAAASHKVKEFCENLS----ADCRE------NVIMSQILPCIKE 332
+L + A RA + EF A E N+I S
Sbjct: 322 DKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKEEVDTGAVNLIESGACGAFVH 381
Query: 333 LVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVN 392
+ D V+ A + L+ + E L + DE EVRL I + ++
Sbjct: 382 GLEDEMYEVRIAAVEALCMLAQ--SSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKIS 439
Query: 393 EVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYM 427
I +R + L ++ + ED+ +R A+ E +
Sbjct: 440 NNITLR---EDQLDTVLAVLEDSSRDIREALHELL 471
>gi|209969836 transportin 2 (importin 3, karyopherin beta 2b)
isoform 3 [Homo sapiens]
Length = 887
Score = 32.7 bits (73), Expect = 0.96
Identities = 92/455 (20%), Positives = 155/455 (34%), Gaps = 72/455 (15%)
Query: 123 DLEAHFVPLVKRLA-GGDWFTSRTSACGLFSVCYPRVSSAVK--AELRQYFRNLCSDDTP 179
+L H +PL+K L +W + L ++ + V EL + SD
Sbjct: 390 ELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKA 449
Query: 180 MVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQED 239
+VR A L +A + + P+ + L D + + AC A L +
Sbjct: 450 LVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEAC 509
Query: 240 LEAL-----VMPTLRQAAEDKSWRVRYMVADKFTELQKAVG-----PEITKTDLVPAFQ- 288
E + ++ TL A + ++ D L +VG PE + + P Q
Sbjct: 510 TELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQK 569
Query: 289 -NLMKD----------CEAEVRAAASHKVKEFCENLSADC----RENVIMSQILPCIKEL 333
N +KD C + V A +CE + C ++ + + + E
Sbjct: 570 WNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQ 629
Query: 334 VSDANQHVKSALASVIMGLSPILGKDNTIEHL------LPLFLAQLKDECPEVRLNIISN 387
++ ++ GL+ LG +E L + L ++D PEVR
Sbjct: 630 YEAPDKDFMIVALDLLSGLAEGLG--GHVEQLVARSNIMTLLFQCMQDSMPEVR------ 681
Query: 388 LDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLC 447
QS + +L + V+ I E+MP+L L EF N+
Sbjct: 682 --------------QSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFISVCNNA-- 725
Query: 448 MAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINV 507
W + + A ++V E + PK L + T I
Sbjct: 726 -TWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLEN----------TAITIGR 774
Query: 508 LSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAK 542
L VC Q++ ML +R + N+R N K
Sbjct: 775 LGYVCPQEVAP--MLQQFIRPWCTSLRNIRDNEEK 807
Score = 29.6 bits (65), Expect = 8.1
Identities = 23/74 (31%), Positives = 38/74 (51%), Gaps = 12/74 (16%)
Query: 32 IKKLSTIALALGVERTRSELLPFLT---DTIYD-----EDEVLLALAEQLGTFTTLVGG- 82
+++ + A A E +EL+P+L+ DT+ + + LL L + +GT VG
Sbjct: 493 VQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHH 552
Query: 83 ---PEYVHCLLPPL 93
PEY+ L+PPL
Sbjct: 553 LNQPEYIQKLMPPL 566
>gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isoform
2 [Homo sapiens]
Length = 887
Score = 32.7 bits (73), Expect = 0.96
Identities = 92/455 (20%), Positives = 155/455 (34%), Gaps = 72/455 (15%)
Query: 123 DLEAHFVPLVKRLA-GGDWFTSRTSACGLFSVCYPRVSSAVK--AELRQYFRNLCSDDTP 179
+L H +PL+K L +W + L ++ + V EL + SD
Sbjct: 390 ELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKA 449
Query: 180 MVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQED 239
+VR A L +A + + P+ + L D + + AC A L +
Sbjct: 450 LVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEAC 509
Query: 240 LEAL-----VMPTLRQAAEDKSWRVRYMVADKFTELQKAVG-----PEITKTDLVPAFQ- 288
E + ++ TL A + ++ D L +VG PE + + P Q
Sbjct: 510 TELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQK 569
Query: 289 -NLMKD----------CEAEVRAAASHKVKEFCENLSADC----RENVIMSQILPCIKEL 333
N +KD C + V A +CE + C ++ + + + E
Sbjct: 570 WNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQ 629
Query: 334 VSDANQHVKSALASVIMGLSPILGKDNTIEHL------LPLFLAQLKDECPEVRLNIISN 387
++ ++ GL+ LG +E L + L ++D PEVR
Sbjct: 630 YEAPDKDFMIVALDLLSGLAEGLG--GHVEQLVARSNIMTLLFQCMQDSMPEVR------ 681
Query: 388 LDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLC 447
QS + +L + V+ I E+MP+L L EF N+
Sbjct: 682 --------------QSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFISVCNNA-- 725
Query: 448 MAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINV 507
W + + A ++V E + PK L + T I
Sbjct: 726 -TWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLEN----------TAITIGR 774
Query: 508 LSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAK 542
L VC Q++ ML +R + N+R N K
Sbjct: 775 LGYVCPQEVAP--MLQQFIRPWCTSLRNIRDNEEK 807
Score = 29.6 bits (65), Expect = 8.1
Identities = 23/74 (31%), Positives = 38/74 (51%), Gaps = 12/74 (16%)
Query: 32 IKKLSTIALALGVERTRSELLPFLT---DTIYD-----EDEVLLALAEQLGTFTTLVGG- 82
+++ + A A E +EL+P+L+ DT+ + + LL L + +GT VG
Sbjct: 493 VQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHH 552
Query: 83 ---PEYVHCLLPPL 93
PEY+ L+PPL
Sbjct: 553 LNQPEYIQKLMPPL 566
>gi|209969838 transportin 2 (importin 3, karyopherin beta 2b)
isoform 1 [Homo sapiens]
Length = 897
Score = 32.0 bits (71), Expect = 1.6
Identities = 91/455 (20%), Positives = 154/455 (33%), Gaps = 62/455 (13%)
Query: 123 DLEAHFVPLVKRLA-GGDWFTSRTSACGLFSVCYPRVSSAVK--AELRQYFRNLCSDDTP 179
+L H +PL+K L +W + L ++ + V EL + SD
Sbjct: 390 ELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKA 449
Query: 180 MVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQED 239
+VR A L +A + + P+ + L D + + AC A L +
Sbjct: 450 LVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEAC 509
Query: 240 LEAL-----VMPTLRQAAEDKSWRVRYMVADKFTELQKAVG-----PEITKTDLVPAFQ- 288
E + ++ TL A + ++ D L +VG PE + + P Q
Sbjct: 510 TELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQK 569
Query: 289 -NLMKD----------CEAEVRAAASHKVKEFCENLSADC----RENVIMSQILPCIKEL 333
N +KD C + V A +CE + C ++ + + + E
Sbjct: 570 WNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQ 629
Query: 334 VSDANQHVKSALASVIMGLSPILGKDNTIEHL------LPLFLAQLKDECPEVRLNIISN 387
++ ++ GL+ LG +E L + L ++D PEVR
Sbjct: 630 YEAPDKDFMIVALDLLSGLAEGLG--GHVEQLVARSNIMTLLFQCMQDSMPEVR------ 681
Query: 388 LDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLC 447
QS + +L + V+ I E+MP+L L EF N+
Sbjct: 682 --------------QSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFISVCNNA-- 725
Query: 448 MAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINV 507
W + + A ++V E + PK L + I
Sbjct: 726 -TWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTGRLTSPSAIPAITIGR 784
Query: 508 LSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAK 542
L VC Q++ ML +R + N+R N K
Sbjct: 785 LGYVCPQEVAP--MLQQFIRPWCTSLRNIRDNEEK 817
Score = 29.6 bits (65), Expect = 8.1
Identities = 23/74 (31%), Positives = 38/74 (51%), Gaps = 12/74 (16%)
Query: 32 IKKLSTIALALGVERTRSELLPFLT---DTIYD-----EDEVLLALAEQLGTFTTLVGG- 82
+++ + A A E +EL+P+L+ DT+ + + LL L + +GT VG
Sbjct: 493 VQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHH 552
Query: 83 ---PEYVHCLLPPL 93
PEY+ L+PPL
Sbjct: 553 LNQPEYIQKLMPPL 566
>gi|115430243 SCY1-like 1 isoform B [Homo sapiens]
Length = 791
Score = 31.6 bits (70), Expect = 2.1
Identities = 43/238 (18%), Positives = 88/238 (36%), Gaps = 7/238 (2%)
Query: 236 PQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCE 295
P++ V+P L A E + +V ++ K + E + ++P + +
Sbjct: 305 PEDFCRHKVLPQLLTAFEFGN--AGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTD 362
Query: 296 AEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPI 355
+R ++++F + L E + +QI P + D N ++ ++ L+P
Sbjct: 363 RAMRIRLLQQMEQFIQYLD----EPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPK 418
Query: 356 LGKDNTIEHLLPLFL-AQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAED 414
L + N L+ F Q KDE +R N L + + + L A D
Sbjct: 419 LNEANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATRD 478
Query: 415 AKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEK 472
R+A + + +K+ + VD ++R+ A ++ + K
Sbjct: 479 PFAPSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSK 536
>gi|115430241 SCY1-like 1 isoform A [Homo sapiens]
Length = 808
Score = 31.6 bits (70), Expect = 2.1
Identities = 43/238 (18%), Positives = 88/238 (36%), Gaps = 7/238 (2%)
Query: 236 PQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCE 295
P++ V+P L A E + +V ++ K + E + ++P + +
Sbjct: 305 PEDFCRHKVLPQLLTAFEFGN--AGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTD 362
Query: 296 AEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPI 355
+R ++++F + L E + +QI P + D N ++ ++ L+P
Sbjct: 363 RAMRIRLLQQMEQFIQYLD----EPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPK 418
Query: 356 LGKDNTIEHLLPLFL-AQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAED 414
L + N L+ F Q KDE +R N L + + + L A D
Sbjct: 419 LNEANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATRD 478
Query: 415 AKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEK 472
R+A + + +K+ + VD ++R+ A ++ + K
Sbjct: 479 PFAPSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSK 536
>gi|7657530 rhabdoid tumor deletion region protein 1 [Homo sapiens]
Length = 348
Score = 31.6 bits (70), Expect = 2.1
Identities = 32/131 (24%), Positives = 55/131 (41%), Gaps = 14/131 (10%)
Query: 312 NLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPIL-GKDNTIE-HLLPLF 369
++S + ++ V ++P + L+ D +HVKS A +M + I GK +E + L
Sbjct: 218 SISREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGALMFATVITEGKYAALEAQAIGLL 277
Query: 370 LAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAI------------VELAEDAKW 417
L L RLN L + E R+ Q+ +P V A
Sbjct: 278 LELLHSPMTIARLNATKALTMLAEAPEGRKALQTHVPTFRAMEVETYEKPQVAEALQRAA 337
Query: 418 RVRLAIIEYMP 428
R+ +++IE+ P
Sbjct: 338 RIAISVIEFKP 348
>gi|50233846 olfactory receptor, family 13, subfamily C, member 3
[Homo sapiens]
Length = 347
Score = 31.6 bits (70), Expect = 2.1
Identities = 21/69 (30%), Positives = 36/69 (52%), Gaps = 1/69 (1%)
Query: 318 RENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDEC 377
R +I+S++ + VS + + SA+ +++ P G +N I H LA LK C
Sbjct: 161 RYPIILSKVAYVLMASVSWLSGGINSAVQTLLAMRLPFCG-NNIINHFACEILAVLKLAC 219
Query: 378 PEVRLNIIS 386
++ LNII+
Sbjct: 220 ADISLNIIT 228
>gi|88853059 diphthamide biosynthesis protein 2 isoform b [Homo
sapiens]
Length = 261
Score = 31.2 bits (69), Expect = 2.8
Identities = 31/105 (29%), Positives = 44/105 (41%), Gaps = 5/105 (4%)
Query: 5 DGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDE 64
DG L +A + +L E V L+ +A+A +E T + L DT Y
Sbjct: 30 DGVYELERVAGFVRDLGCERVALQFPDQLLGDAVAVAARLEETTGSKMFILGDTAYGSCC 89
Query: 65 VLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAV 109
V + AEQ G + GP CL PP L V+R ++V
Sbjct: 90 VDVLGAEQAGAQALIHFGPA---CLSPPARPLPVA--FVLRQRSV 129
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,280,349
Number of Sequences: 37866
Number of extensions: 761904
Number of successful extensions: 2190
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 1990
Number of HSP's gapped (non-prelim): 115
length of query: 589
length of database: 18,247,518
effective HSP length: 108
effective length of query: 481
effective length of database: 14,157,990
effective search space: 6809993190
effective search space used: 6809993190
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.