Search of human proteins with 21361151

Search of human proteins with 21361151

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo
sapiens]
         (743 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo s...  1505   0.0  
gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo ...  1358   0.0  
gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo ...  1176   0.0  
gi|34915994 transducin-like enhancer protein 4 [Homo sapiens]         998   0.0  
gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]         986   0.0  
gi|157384986 transducin-like enhancer protein 3 isoform b [Homo ...   974   0.0  
gi|157384982 transducin-like enhancer protein 3 isoform a [Homo ...   973   0.0  
gi|157384984 transducin-like enhancer protein 3 isoform c [Homo ...   968   0.0  
gi|221136834 transducin-like enhancer of split 6 isoform 1 [Homo...   218   2e-56
gi|13376099 transducin-like enhancer of split 6 isoform 2 [Homo ...   218   2e-56
gi|5706731 amino-terminal enhancer of split isoform b [Homo sapi...   217   3e-56
gi|39812027 amino-terminal enhancer of split isoform c [Homo sap...   214   3e-55
gi|39812019 amino-terminal enhancer of split isoform a [Homo sap...   208   1e-53
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             89   1e-17
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             89   1e-17
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             89   1e-17
gi|26665869 WD repeat domain 51B [Homo sapiens]                        83   8e-16
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    80   5e-15
gi|113865883 WD repeat domain 38 [Homo sapiens]                        80   9e-15
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is...    75   3e-13
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i...    75   3e-13
gi|5174447 guanine nucleotide binding protein (G protein), beta ...    72   2e-12
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     72   2e-12
gi|8923881 WD SOCS-box protein 2 [Homo sapiens]                        70   7e-12
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...    69   2e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     68   4e-11
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H...    66   1e-10
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ...    66   1e-10
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [...    64   4e-10
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     64   5e-10

>gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo
           sapiens]
          Length = 743

 Score = 1505 bits (3897), Expect = 0.0
 Identities = 743/743 (100%), Positives = 743/743 (100%)

Query: 1   MYPQGRHPTPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHY 60
           MYPQGRHPTPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHY
Sbjct: 1   MYPQGRHPTPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHY 60

Query: 61  VMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNS 120
           VMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNS
Sbjct: 61  VMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNS 120

Query: 121 LIGQQLQPLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAE 180
           LIGQQLQPLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAE
Sbjct: 121 LIGQQLQPLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAE 180

Query: 181 GSRVERAPSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVD 240
           GSRVERAPSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVD
Sbjct: 181 GSRVERAPSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVD 240

Query: 241 EDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILNDLPASTPA 300
           EDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILNDLPASTPA
Sbjct: 241 EDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILNDLPASTPA 300

Query: 301 SKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHST 360
           SKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHST
Sbjct: 301 SKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHST 360

Query: 361 LNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYS 420
           LNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYS
Sbjct: 361 LNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYS 420

Query: 421 FHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCV 480
           FHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCV
Sbjct: 421 FHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCV 480

Query: 481 KVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIK 540
           KVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIK
Sbjct: 481 KVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIK 540

Query: 541 AELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDY 600
           AELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDY
Sbjct: 541 AELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDY 600

Query: 601 GTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVR 660
           GTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVR
Sbjct: 601 GTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVR 660

Query: 661 KPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDI 720
           KPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDI
Sbjct: 661 KPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDI 720

Query: 721 SRNNKYIVTGSGDKKATVYEVVY 743
           SRNNKYIVTGSGDKKATVYEVVY
Sbjct: 721 SRNNKYIVTGSGDKKATVYEVVY 743


>gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo
           sapiens]
          Length = 706

 Score = 1358 bits (3514), Expect = 0.0
 Identities = 674/675 (99%), Positives = 674/675 (99%), Gaps = 1/675 (0%)

Query: 9   TPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSY 68
           TPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSY
Sbjct: 22  TPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSY 81

Query: 69  GLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQ-LQ 127
           GLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQ LQ
Sbjct: 82  GLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQQLQ 141

Query: 128 PLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAEGSRVERA 187
           PLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAEGSRVERA
Sbjct: 142 PLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAEGSRVERA 201

Query: 188 PSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVDEDQPSEP 247
           PSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVDEDQPSEP
Sbjct: 202 PSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVDEDQPSEP 261

Query: 248 PSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILNDLPASTPASKSCDSS 307
           PSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILNDLPASTPASKSCDSS
Sbjct: 262 PSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILNDLPASTPASKSCDSS 321

Query: 308 PPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHSTLNGDLSV 367
           PPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHSTLNGDLSV
Sbjct: 322 PPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHSTLNGDLSV 381

Query: 368 PSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADG 427
           PSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADG
Sbjct: 382 PSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADG 441

Query: 428 QMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQ 487
           QMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQ
Sbjct: 442 QMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQ 501

Query: 488 PGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSA 547
           PGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSA
Sbjct: 502 PGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSA 561

Query: 548 PACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTG 607
           PACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTG
Sbjct: 562 PACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTG 621

Query: 608 GLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQL 667
           GLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQL
Sbjct: 622 GLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQL 681

Query: 668 HLHESCVLSLKFASC 682
           HLHESCVLSLKFASC
Sbjct: 682 HLHESCVLSLKFASC 696


>gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo
           sapiens]
          Length = 621

 Score = 1176 bits (3042), Expect = 0.0
 Identities = 599/690 (86%), Positives = 605/690 (87%), Gaps = 71/690 (10%)

Query: 56  MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 115
           MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV
Sbjct: 1   MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60

Query: 116 GELNSLIGQQLQPLSHHAPPVPLT--PRPAGLVGGSATGLLALSGALAAQAQLAAAVKED 173
           GELNSLIG      +  +PP  L    RP+G  GG                         
Sbjct: 61  GELNSLIGS-----ASPSPPESLVEEERPSGPGGGG------------------------ 91

Query: 174 RAGVEAEGSRVERAPSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKS 233
                                   +   +E+ PSG                PYESDEDKS
Sbjct: 92  ------------------------KQRADEKEPSG----------------PYESDEDKS 111

Query: 234 DYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILND 293
           DYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILND
Sbjct: 112 DYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILND 171

Query: 294 LPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSF 353
           LPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSF
Sbjct: 172 LPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSF 231

Query: 354 SLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIP 413
           SLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIP
Sbjct: 232 SLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIP 291

Query: 414 GGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVY 473
           GGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVY
Sbjct: 292 GGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVY 351

Query: 474 TGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLA 533
           TGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLA
Sbjct: 352 TGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLA 411

Query: 534 APTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGAS 593
           APTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGAS
Sbjct: 412 APTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGAS 471

Query: 594 CIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSN 653
           CIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSN
Sbjct: 472 CIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSN 531

Query: 654 VEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESS 713
           VEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESS
Sbjct: 532 VEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESS 591

Query: 714 SVLSCDISRNNKYIVTGSGDKKATVYEVVY 743
           SVLSCDISRNNKYIVTGSGDKKATVYEVVY
Sbjct: 592 SVLSCDISRNNKYIVTGSGDKKATVYEVVY 621


>gi|34915994 transducin-like enhancer protein 4 [Homo sapiens]
          Length = 773

 Score =  998 bits (2580), Expect = 0.0
 Identities = 522/774 (67%), Positives = 608/774 (78%), Gaps = 39/774 (5%)

Query: 1   MYPQGRHPTPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHY 60
           MYPQ RHP P Q  QPFKF+I E CDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHY
Sbjct: 8   MYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHY 67

Query: 61  VMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNS 120
           VMYYEMSYGLNIEMHKQAEIVKRL+ ICAQ+IPFL+QEHQQQV+QAVERAKQVT+ ELN+
Sbjct: 68  VMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNA 127

Query: 121 LIGQQLQP--LSH-HAPPVPLTPRPAGLVG------GSATGLLALSGALAAQAQLAAAVK 171
           +IGQQLQ   LSH H  PVPLTP P+GL        GS+ GLLALS AL  Q+ L   +K
Sbjct: 128 IIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLP--IK 185

Query: 172 EDRAGVEAEGSRVERAPSRSASPSPPESL--VEEERPSGP--GGGGKQRADEKEPSGPYE 227
           +++   + +  R +R   +S+S SP  S    E+ R S        KQ+ +EKE +  Y+
Sbjct: 186 DEKKHHDNDHQR-DRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYD 244

Query: 228 SDEDKSDYNLVVD---EDQPSEPPSPATTP----CGKVPICIPARRDLVDSPASLASSLG 280
           SD +KSD NLVVD   ED  S   SPA +P      K  +    ++D   SPAS+ASS  
Sbjct: 245 SDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLL---KKDAPISPASIASSSS 301

Query: 281 SPLPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVA-- 338
           +P  ++KEL LN+  ++TP SKS   +P  DA TPG +S   L  +  KP P  D +A  
Sbjct: 302 TPSSKSKELSLNE-KSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKP-PGVDPLASS 359

Query: 339 LRSPLTLSSPFTTSFSLGSHSTLNGDLSVP-SSYVSLH-LSPQVSSSVV-------YGRS 389
           LR+P+ +  P+ T F +  H+ +NG+L+ P ++Y  LH +SPQ+S++         YGRS
Sbjct: 360 LRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRS 419

Query: 390 PVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHAR 449
           PV+ F+ H H+R  ++  +L  IPGGKPAYSFHVSADGQMQPVPFP DAL+G GIPRHAR
Sbjct: 420 PVVGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHAR 479

Query: 450 QLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSC 509
           Q++TL HGEVVCAVTIS  T+HVYTGGKGCVKVWD+  PG K+PV+QLDCLNRDNYIRSC
Sbjct: 480 QINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSC 539

Query: 510 KLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDG 569
           +LLPDGR+LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALA+SPD+KVCFSCCSDG
Sbjct: 540 RLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDG 599

Query: 570 NIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDF 629
           NI VWDL NQT+VRQFQGHTDGASCIDIS+ GT+LWTGGLDNTVR WDLREGRQLQQHDF
Sbjct: 600 NIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDF 659

Query: 630 SSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVST 689
           +SQIFSLG+CP  +WLAVGME+SNVE+LHV KP+KYQLHLHESCVLSLKFA CG+WFVST
Sbjct: 660 TSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVST 719

Query: 690 GKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY 743
           GKDNLLNAWRTPYGASIFQSKESSSVLSCDIS ++KYIVTGSGDKKATVYEV+Y
Sbjct: 720 GKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 773


>gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]
          Length = 770

 Score =  986 bits (2548), Expect = 0.0
 Identities = 524/777 (67%), Positives = 608/777 (78%), Gaps = 41/777 (5%)

Query: 1   MYPQGRHPTPLQS-GQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 59
           M+PQ RHPTP Q+ GQPFKF+I E  DRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH
Sbjct: 1   MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 60

Query: 60  YVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELN 119
           YVMYYEMSYGLNIEMHKQ EI KRL+ ICAQ+IPFL+QEHQQQV QAVERAKQVT+ ELN
Sbjct: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELN 120

Query: 120 SLIGQQ---LQPLSH-HAPPVPLTPRPAGL-------VGGSATGLLALSGALAAQAQLAA 168
           ++IGQQ    Q LSH H PPVPLTP P+GL       +GGSA GLLALS AL+ Q+ LA 
Sbjct: 121 AIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSA-GLLALSSALSGQSHLA- 178

Query: 169 AVKEDRAGVEAEGSRVERAPSRSASPSPPESLV-EEERPSGPGGGG---KQRADEKEPSG 224
            +K+D+   +AE  R +R P  S S   P+SL   ++R +GP       K++ D+K+ S 
Sbjct: 179 -IKDDKKHHDAEHHR-DREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKD-SS 235

Query: 225 PYESDEDKSDYNLVVD---EDQPSEPPSPATTPCGK-VPICIPARRDLVDSPASLASSLG 280
            Y+SD DKSD NLVVD   ED  S   SPA +P    +      ++D   SPAS ASS  
Sbjct: 236 HYDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSAS 295

Query: 281 SPLPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTD----- 335
           S   ++KE+ L++  ASTP  KS   +P  D  TPG S+   L     KP P+ D     
Sbjct: 296 STSLKSKEMSLHE-KASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKP-PAIDPLVNQ 353

Query: 336 -SVALRSPLTLSSPFTTSFSLGSHSTLNGDLSVP-SSYVSLH-LSPQVSSS------VVY 386
            +  LR+PL +  P+   F +  H+ +NG+L+ P ++Y SLH +SPQ+S++      V Y
Sbjct: 354 AAAGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAY 413

Query: 387 GRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPR 446
           GRSP++ F+  PH+R  ++  +L  IPGGKPAYSFHV+ADGQMQPVPFP DAL+G GIPR
Sbjct: 414 GRSPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPR 473

Query: 447 HARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYI 506
           HARQ++TL HGEVVCAVTIS  T+HVYTGGKGCVKVWD+  PG K+PV+QLDCLNRDNYI
Sbjct: 474 HARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYI 533

Query: 507 RSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCC 566
           RSCKLLPDG +LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALA+SPD+KVCFSCC
Sbjct: 534 RSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCC 593

Query: 567 SDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 626
           SDGNI VWDL NQT+VRQFQGHTDGASCIDIS+ GT+LWTGGLDNTVR WDLREGRQLQQ
Sbjct: 594 SDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ 653

Query: 627 HDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRWF 686
           HDF+SQIFSLG+CP  +WLAVGMESSNVE+LHV KP+KYQLHLHESCVLSLKFA CG+WF
Sbjct: 654 HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWF 713

Query: 687 VSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY 743
           VSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS ++KYIVTGSGDKKATVYEV+Y
Sbjct: 714 VSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 770


>gi|157384986 transducin-like enhancer protein 3 isoform b [Homo
           sapiens]
          Length = 769

 Score =  974 bits (2518), Expect = 0.0
 Identities = 512/778 (65%), Positives = 601/778 (77%), Gaps = 44/778 (5%)

Query: 1   MYPQGRHPTPLQSGQP-FKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 59
           MYPQGRHP P Q GQP FKF++ E CDRIK+EFQFLQAQYHSLK+E +KLA+EKTEMQRH
Sbjct: 1   MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH 60

Query: 60  YVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELN 119
           YVMYYEMSYGLNIEMHKQ EI KRL+ I AQI+PFL+QEHQQQV QAVERAKQVT+ ELN
Sbjct: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN 120

Query: 120 SLIGQQ---LQPLSH--HAPPVPLTPRPAGL-------VGGSATGLLALSGALAAQAQLA 167
           ++IGQQ    Q LSH  H PPV L P P+GL       V GS++GLLAL GAL +QA L 
Sbjct: 121 AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLAL-GALGSQAHLT 179

Query: 168 AAVKEDRAGVEAEGSRVERAPSRSASPSPPESLVEEERPSGPGG----GGKQRADEKEPS 223
             VK+++   E +    ER  S + S SP ESL   E+  G         K++A+EK+  
Sbjct: 180 --VKDEKNHHELDHR--ERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSL 235

Query: 224 GPYESDEDKSDYNLVVDEDQPSEPPSPATTPCGKVPI-----CIPARRDLVDSPASLASS 278
             Y+SD DKSD +LVVD     +P +P  +P    P          ++D   SPAS+ASS
Sbjct: 236 SRYDSDGDKSD-DLVVDVSN-EDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASS 293

Query: 279 LGSPLPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVA 338
             +P  + K+L  ND  +STP  KS   +P  DA TPG S+   L  +  KP P  D +A
Sbjct: 294 SSTPSSKTKDLGHND-KSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKP-PGMDPIA 351

Query: 339 --LRSPLTLSSPFTTSFSLGSHSTLNGDLSVPSSYVSLH-LSPQVSSSVV-----YGRSP 390
             LR+P++++S +   F++ SH  +NG L+ P +Y  LH + PQ+S++       YGRSP
Sbjct: 352 SALRTPISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSP 411

Query: 391 VMAF-----ESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIP 445
           +++F     + HP +R + + SSL SIPGGKPAYSFHVSADGQMQPVPFP DAL G GIP
Sbjct: 412 MVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIP 471

Query: 446 RHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNY 505
           RHARQ++TL+HGEVVCAVTIS  T+HVYTGGKGCVK+WD+ QPG+K+P++QLDCLNRDNY
Sbjct: 472 RHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNY 531

Query: 506 IRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSC 565
           IRSCKLLPDGR+LIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALA+SPDAKVCFSC
Sbjct: 532 IRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSC 591

Query: 566 CSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQ 625
           CSDGNI VWDL NQT+VRQFQGHTDGASCIDIS  GT+LWTGGLDNTVR WDLREGRQLQ
Sbjct: 592 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQ 651

Query: 626 QHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRW 685
           QHDF+SQIFSLG+CP  +WLAVGMESSNVE+LH  KP+KYQLHLHESCVLSLKFA CG+W
Sbjct: 652 QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKW 711

Query: 686 FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY 743
           FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS ++KYIVTGSGDKKATVYEV+Y
Sbjct: 712 FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 769


>gi|157384982 transducin-like enhancer protein 3 isoform a [Homo
           sapiens]
          Length = 772

 Score =  973 bits (2515), Expect = 0.0
 Identities = 512/781 (65%), Positives = 601/781 (76%), Gaps = 47/781 (6%)

Query: 1   MYPQGRHPTPLQSGQP-FKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 59
           MYPQGRHP P Q GQP FKF++ E CDRIK+EFQFLQAQYHSLK+E +KLA+EKTEMQRH
Sbjct: 1   MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH 60

Query: 60  YVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELN 119
           YVMYYEMSYGLNIEMHKQ EI KRL+ I AQI+PFL+QEHQQQV QAVERAKQVT+ ELN
Sbjct: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN 120

Query: 120 SLIGQQ---LQPLSH--HAPPVPLTPRPAGL-------VGGSATGLLALSGALAAQAQLA 167
           ++IGQQ    Q LSH  H PPV L P P+GL       V GS++GLLAL GAL +QA L 
Sbjct: 121 AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLAL-GALGSQAHLT 179

Query: 168 AAVKEDRAGVEAEGSRVERAPSRSASPSPPESLVEEERPSGPGG----GGKQRADEKEPS 223
             VK+++   E +    ER  S + S SP ESL   E+  G         K++A+EK+  
Sbjct: 180 --VKDEKNHHELDHR--ERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSL 235

Query: 224 GPYESDEDKSDYNLVVDEDQPSEPPSPATTPCGKVPI-----CIPARRDLVDSPASLASS 278
             Y+SD DKSD +LVVD     +P +P  +P    P          ++D   SPAS+ASS
Sbjct: 236 SRYDSDGDKSD-DLVVDVSN-EDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASS 293

Query: 279 LGSPLPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSV- 337
             +P  + K+L  ND  +STP  KS   +P  DA TPG S+   L  +  KP P  D + 
Sbjct: 294 SSTPSSKTKDLGHND-KSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKP-PGMDPIG 351

Query: 338 ----ALRSPLTLSSPFTTSFSLGSHSTLNGDLSVPSSYVSLH-LSPQVSSSVV-----YG 387
               ALR+P++++S +   F++ SH  +NG L+ P +Y  LH + PQ+S++       YG
Sbjct: 352 IMASALRTPISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYG 411

Query: 388 RSPVMAF-----ESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGA 442
           RSP+++F     + HP +R + + SSL SIPGGKPAYSFHVSADGQMQPVPFP DAL G 
Sbjct: 412 RSPMVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGP 471

Query: 443 GIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNR 502
           GIPRHARQ++TL+HGEVVCAVTIS  T+HVYTGGKGCVK+WD+ QPG+K+P++QLDCLNR
Sbjct: 472 GIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNR 531

Query: 503 DNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVC 562
           DNYIRSCKLLPDGR+LIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALA+SPDAKVC
Sbjct: 532 DNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVC 591

Query: 563 FSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGR 622
           FSCCSDGNI VWDL NQT+VRQFQGHTDGASCIDIS  GT+LWTGGLDNTVR WDLREGR
Sbjct: 592 FSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGR 651

Query: 623 QLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASC 682
           QLQQHDF+SQIFSLG+CP  +WLAVGMESSNVE+LH  KP+KYQLHLHESCVLSLKFA C
Sbjct: 652 QLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYC 711

Query: 683 GRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVV 742
           G+WFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS ++KYIVTGSGDKKATVYEV+
Sbjct: 712 GKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVI 771

Query: 743 Y 743
           Y
Sbjct: 772 Y 772


>gi|157384984 transducin-like enhancer protein 3 isoform c [Homo
           sapiens]
          Length = 760

 Score =  968 bits (2502), Expect = 0.0
 Identities = 509/776 (65%), Positives = 597/776 (76%), Gaps = 49/776 (6%)

Query: 1   MYPQGRHPTPLQSGQP-FKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 59
           MYPQGRHP P Q GQP FKF++ E CDRIK+EFQFLQAQYHSLK+E +KLA+EKTEMQRH
Sbjct: 1   MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH 60

Query: 60  YVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELN 119
           YVMYYEMSYGLNIEMHKQ EI KRL+ I AQI+PFL+QEHQQQV QAVERAKQVT+ ELN
Sbjct: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN 120

Query: 120 SLIGQQ---LQPLSH--HAPPVPLTPRPAGL-------VGGSATGLLALSGALAAQAQLA 167
           ++IGQQ    Q LSH  H PPV L P P+GL       V GS++GLLAL GAL +QA L 
Sbjct: 121 AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLAL-GALGSQAHLT 179

Query: 168 AAVKEDRAGVEAEGSRVERAPSRSASPSPPESLVEEERPSGPGG----GGKQRADEKEPS 223
             VK+++   E +    ER  S + S SP ESL   E+  G         K++A+EK+  
Sbjct: 180 --VKDEKNHHELDHR--ERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSL 235

Query: 224 GPYESDEDKSDYNLVVDEDQPSEPPSPATTPCGKVPI-----CIPARRDLVDSPASLASS 278
             Y+SD DKSD +LVVD     +P +P  +P    P          ++D   SPAS+ASS
Sbjct: 236 SRYDSDGDKSD-DLVVDVSN-EDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASS 293

Query: 279 LGSPLPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVA 338
             +P  + K+L  ND  +STP  KS   +P  DA TPG S+   L  + A         A
Sbjct: 294 SSTPSSKTKDLGHND-KSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPAS--------A 344

Query: 339 LRSPLTLSSPFTTSFSLGSHSTLNGDLSVPSSYVSLH-LSPQVSSSVV-----YGRSPVM 392
           LR+P++++S +   F++ SH  +NG L+ P +Y  LH + PQ+S++       YGRSP++
Sbjct: 345 LRTPISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMV 404

Query: 393 AF-----ESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRH 447
           +F     + HP +R + + SSL SIPGGKPAYSFHVSADGQMQPVPFP DAL G GIPRH
Sbjct: 405 SFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRH 464

Query: 448 ARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIR 507
           ARQ++TL+HGEVVCAVTIS  T+HVYTGGKGCVK+WD+ QPG+K+P++QLDCLNRDNYIR
Sbjct: 465 ARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIR 524

Query: 508 SCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCS 567
           SCKLLPDGR+LIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALA+SPDAKVCFSCCS
Sbjct: 525 SCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCS 584

Query: 568 DGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQH 627
           DGNI VWDL NQT+VRQFQGHTDGASCIDIS  GT+LWTGGLDNTVR WDLREGRQLQQH
Sbjct: 585 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQH 644

Query: 628 DFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRWFV 687
           DF+SQIFSLG+CP  +WLAVGMESSNVE+LH  KP+KYQLHLHESCVLSLKFA CG+WFV
Sbjct: 645 DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFV 704

Query: 688 STGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY 743
           STGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS ++KYIVTGSGDKKATVYEV+Y
Sbjct: 705 STGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 760


>gi|221136834 transducin-like enhancer of split 6 isoform 1 [Homo
           sapiens]
          Length = 572

 Score =  218 bits (554), Expect = 2e-56
 Identities = 114/314 (36%), Positives = 182/314 (57%), Gaps = 10/314 (3%)

Query: 437 DALVGAG----IPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDV-GQPGA- 490
           DAL G      +P    ++  LAHGE+V A  IS  T+HV+T G+  +KVW + GQ    
Sbjct: 262 DALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAED 321

Query: 491 KTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGG-EASTLSIWDLAAPTPRIKAELTSSAPA 549
           + P + L       ++R+C L  + RSL+ GG   +++S+WDLAAP+  +K +L  +   
Sbjct: 322 RFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGLN 381

Query: 550 CYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGL 609
           C AL  + DA + F+  + G + +WDL++Q++VR  +G+ DG   I +  Y   +WTGG 
Sbjct: 382 CQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYN--IWTGGP 439

Query: 610 DNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHL 669
           D  +RCWD R   +  ++ F SQI SL H P +DW+ +GM +    +      +++ +  
Sbjct: 440 DACLRCWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVGQ 499

Query: 670 HESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVT 729
            +S +LS+KF+  G+W+ S G D+ L  +  P G  +F+  E S V  CD+S NN+ +VT
Sbjct: 500 KDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMSPVTCCDVSSNNRLVVT 559

Query: 730 GSGDKKATVYEVVY 743
           GSG+  A+VY++ Y
Sbjct: 560 GSGE-HASVYQITY 572


>gi|13376099 transducin-like enhancer of split 6 isoform 2 [Homo
           sapiens]
          Length = 449

 Score =  218 bits (554), Expect = 2e-56
 Identities = 114/314 (36%), Positives = 182/314 (57%), Gaps = 10/314 (3%)

Query: 437 DALVGAG----IPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDV-GQPGA- 490
           DAL G      +P    ++  LAHGE+V A  IS  T+HV+T G+  +KVW + GQ    
Sbjct: 139 DALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAED 198

Query: 491 KTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGG-EASTLSIWDLAAPTPRIKAELTSSAPA 549
           + P + L       ++R+C L  + RSL+ GG   +++S+WDLAAP+  +K +L  +   
Sbjct: 199 RFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGLN 258

Query: 550 CYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGL 609
           C AL  + DA + F+  + G + +WDL++Q++VR  +G+ DG   I +  Y   +WTGG 
Sbjct: 259 CQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYN--IWTGGP 316

Query: 610 DNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHL 669
           D  +RCWD R   +  ++ F SQI SL H P +DW+ +GM +    +      +++ +  
Sbjct: 317 DACLRCWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVGQ 376

Query: 670 HESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVT 729
            +S +LS+KF+  G+W+ S G D+ L  +  P G  +F+  E S V  CD+S NN+ +VT
Sbjct: 377 KDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMSPVTCCDVSSNNRLVVT 436

Query: 730 GSGDKKATVYEVVY 743
           GSG+  A+VY++ Y
Sbjct: 437 GSGE-HASVYQITY 449


>gi|5706731 amino-terminal enhancer of split isoform b [Homo
           sapiens]
          Length = 197

 Score =  217 bits (553), Expect = 3e-56
 Identities = 121/189 (64%), Positives = 142/189 (75%), Gaps = 13/189 (6%)

Query: 1   MYPQGRHPTPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHY 60
           M+PQ RH       Q  KF+  + CDRIK+EFQ LQAQYHSLKLEC+KLASEK+EMQRHY
Sbjct: 2   MFPQSRHSGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHY 61

Query: 61  VMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNS 120
           VMYYEMSYGLNIEMHKQAEIVKRL+GICAQ++P+L+QEHQQQVL A+ERAKQVT  ELNS
Sbjct: 62  VMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNS 121

Query: 121 LIGQQLQ--PLSH-HAPPVPLTPRPAGL------VGGSATGLLALSGALAAQAQLAAAVK 171
           +I QQLQ   LS   A  +PLTP P GL         + TGLL+LS AL +QA L+   K
Sbjct: 122 IIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTGLLSLS-ALGSQAHLS---K 177

Query: 172 EDRAGVEAE 180
           ED+ G + +
Sbjct: 178 EDKNGHDGD 186


>gi|39812027 amino-terminal enhancer of split isoform c [Homo
           sapiens]
          Length = 196

 Score =  214 bits (544), Expect = 3e-55
 Identities = 119/188 (63%), Positives = 140/188 (74%), Gaps = 12/188 (6%)

Query: 1   MYPQGRHPTPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHY 60
           M+PQ RH       Q  KF+  + CDRIK+EFQ LQAQYHSLKLEC+KLASEK+EMQRHY
Sbjct: 2   MFPQSRHSGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHY 61

Query: 61  VMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNS 120
           VMYYEMSYGLNIEMHKQAEIVKRL+GICAQ++P+L+QEHQQQVL A+ERAKQVT  ELNS
Sbjct: 62  VMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNS 121

Query: 121 LIGQ-QLQPLSH-HAPPVPLTPRPAGL------VGGSATGLLALSGALAAQAQLAAAVKE 172
           +I Q Q   LS   A  +PLTP P GL         + TGLL+LS AL +QA L+   KE
Sbjct: 122 IIRQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTGLLSLS-ALGSQAHLS---KE 177

Query: 173 DRAGVEAE 180
           D+ G + +
Sbjct: 178 DKNGHDGD 185


>gi|39812019 amino-terminal enhancer of split isoform a [Homo
           sapiens]
          Length = 264

 Score =  208 bits (530), Expect = 1e-53
 Identities = 116/175 (66%), Positives = 136/175 (77%), Gaps = 13/175 (7%)

Query: 15  QPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEM 74
           Q  KF+  + CDRIK+EFQ LQAQYHSLKLEC+KLASEK+EMQRHYVMYYEMSYGLNIEM
Sbjct: 83  QQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNIEM 142

Query: 75  HKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQLQ--PLSH- 131
           HKQAEIVKRL+GICAQ++P+L+QEHQQQVL A+ERAKQVT  ELNS+I QQLQ   LS  
Sbjct: 143 HKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQL 202

Query: 132 HAPPVPLTPRPAGL------VGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAE 180
            A  +PLTP P GL         + TGLL+LS AL +QA L+   KED+ G + +
Sbjct: 203 QALALPLTPLPVGLQPPSLPAVSAGTGLLSLS-ALGSQAHLS---KEDKNGHDGD 253


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 61/258 (23%), Positives = 108/258 (41%), Gaps = 10/258 (3%)

Query: 448 ARQLHTLAHGEVVCAVTISGSTQHVYTGGKG-CVKVWDVGQPGAKTPVAQLDCLNRDNYI 506
           +R      H + V  V  S S   + +G +   V++W     G  T             +
Sbjct: 14  SRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT-----V 68

Query: 507 RSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCC 566
           RS     DG+S +   +  T+ +W  A    +    L+           SPD ++  S  
Sbjct: 69  RSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 126

Query: 567 SDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 626
            D  + +WD  ++  V  +  H    + +D    GT +   G+DNTV+ WD+R  R LQ 
Sbjct: 127 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 186

Query: 627 HDF-SSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFASCGR 684
           +   S+ +  L   P+ ++L      S ++IL + +    Y LH H+    ++ F+  G 
Sbjct: 187 YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGE 246

Query: 685 WFVSTGKDNLLNAWRTPY 702
           +F S G D  +  W++ +
Sbjct: 247 YFASGGSDEQVMVWKSNF 264



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 34/133 (25%), Positives = 58/133 (43%), Gaps = 2/133 (1%)

Query: 568 DGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLR-EGRQLQQ 626
           D  ++VW ++ Q+   +F GH D  +C++ S  G  L +G  D TVR W    +G     
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 627 HDFSSQIFSLGHCPNQDWLAVGMESSNVEILHV-RKPEKYQLHLHESCVLSLKFASCGRW 685
              ++ + S+  C +        +   V++    R+   + L  H + V   KF+  GR 
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121

Query: 686 FVSTGKDNLLNAW 698
            VS   D  +  W
Sbjct: 122 IVSASDDKTVKLW 134


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 61/258 (23%), Positives = 108/258 (41%), Gaps = 10/258 (3%)

Query: 448 ARQLHTLAHGEVVCAVTISGSTQHVYTGGKG-CVKVWDVGQPGAKTPVAQLDCLNRDNYI 506
           +R      H + V  V  S S   + +G +   V++W     G  T             +
Sbjct: 52  SRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT-----V 106

Query: 507 RSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCC 566
           RS     DG+S +   +  T+ +W  A    +    L+           SPD ++  S  
Sbjct: 107 RSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 164

Query: 567 SDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 626
            D  + +WD  ++  V  +  H    + +D    GT +   G+DNTV+ WD+R  R LQ 
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224

Query: 627 HDF-SSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFASCGR 684
           +   S+ +  L   P+ ++L      S ++IL + +    Y LH H+    ++ F+  G 
Sbjct: 225 YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGE 284

Query: 685 WFVSTGKDNLLNAWRTPY 702
           +F S G D  +  W++ +
Sbjct: 285 YFASGGSDEQVMVWKSNF 302



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 40/167 (23%), Positives = 74/167 (44%), Gaps = 3/167 (1%)

Query: 577 QNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLR-EGRQLQQHDFSSQIFS 635
           ++ ++ R F+GH D  +C+D S    +L +G +D+ +  W ++ + R  +       +  
Sbjct: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66

Query: 636 LGHCPNQDWLAVGMESSNVEILHVR-KPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNL 694
           +   P+   LA G     V I     K E      H + V S+ F S G+ FV+   D  
Sbjct: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126

Query: 695 LNAWRTPYGASIFQSKESSSVLSC-DISRNNKYIVTGSGDKKATVYE 740
           +  W T     +F   +  + + C   S + + IV+ S DK   +++
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 40/167 (23%), Positives = 68/167 (40%), Gaps = 2/167 (1%)

Query: 534 APTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGAS 593
           A  P ++        A   +  S + K   S   D  ++VW ++ Q+   +F GH D  +
Sbjct: 6   AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65

Query: 594 CIDISDYGTRLWTGGLDNTVRCWDLR-EGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESS 652
           C++ S  G  L +G  D TVR W    +G        ++ + S+  C +        +  
Sbjct: 66  CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125

Query: 653 NVEILHV-RKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAW 698
            V++    R+   + L  H + V   KF+  GR  VS   D  +  W
Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 61/258 (23%), Positives = 108/258 (41%), Gaps = 10/258 (3%)

Query: 448 ARQLHTLAHGEVVCAVTISGSTQHVYTGGKG-CVKVWDVGQPGAKTPVAQLDCLNRDNYI 506
           +R      H + V  V  S S   + +G +   V++W     G  T             +
Sbjct: 52  SRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT-----V 106

Query: 507 RSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCC 566
           RS     DG+S +   +  T+ +W  A    +    L+           SPD ++  S  
Sbjct: 107 RSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 164

Query: 567 SDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 626
            D  + +WD  ++  V  +  H    + +D    GT +   G+DNTV+ WD+R  R LQ 
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224

Query: 627 HDF-SSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFASCGR 684
           +   S+ +  L   P+ ++L      S ++IL + +    Y LH H+    ++ F+  G 
Sbjct: 225 YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGE 284

Query: 685 WFVSTGKDNLLNAWRTPY 702
           +F S G D  +  W++ +
Sbjct: 285 YFASGGSDEQVMVWKSNF 302



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 40/167 (23%), Positives = 74/167 (44%), Gaps = 3/167 (1%)

Query: 577 QNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLR-EGRQLQQHDFSSQIFS 635
           ++ ++ R F+GH D  +C+D S    +L +G +D+ +  W ++ + R  +       +  
Sbjct: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66

Query: 636 LGHCPNQDWLAVGMESSNVEILHVR-KPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNL 694
           +   P+   LA G     V I     K E      H + V S+ F S G+ FV+   D  
Sbjct: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126

Query: 695 LNAWRTPYGASIFQSKESSSVLSC-DISRNNKYIVTGSGDKKATVYE 740
           +  W T     +F   +  + + C   S + + IV+ S DK   +++
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 40/167 (23%), Positives = 68/167 (40%), Gaps = 2/167 (1%)

Query: 534 APTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGAS 593
           A  P ++        A   +  S + K   S   D  ++VW ++ Q+   +F GH D  +
Sbjct: 6   AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65

Query: 594 CIDISDYGTRLWTGGLDNTVRCWDLR-EGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESS 652
           C++ S  G  L +G  D TVR W    +G        ++ + S+  C +        +  
Sbjct: 66  CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125

Query: 653 NVEILHV-RKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAW 698
            V++    R+   + L  H + V   KF+  GR  VS   D  +  W
Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 83.2 bits (204), Expect = 8e-16
 Identities = 63/259 (24%), Positives = 106/259 (40%), Gaps = 10/259 (3%)

Query: 447 HARQLHTLAHGEVVCAVTISGSTQHVYTGGKG-CVKVWDVGQPGAKTPVAQLDCLNRDNY 505
           HAR    + H +VV +V  S     + +  +   V++W   + G  +             
Sbjct: 50  HARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKA-----HTAP 104

Query: 506 IRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSC 565
           +RS     DG+ L    E  ++ +W +     R    L            SPD ++  SC
Sbjct: 105 VRSVDFSADGQFLATASEDKSIKVWSMYRQ--RFLYSLYRHTHWVRCAKFSPDGRLIVSC 162

Query: 566 CSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQ 625
             D  I +WD  N+  V  F      A+ +D +  GT + + G D TV+ WD+R  + LQ
Sbjct: 163 SEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQ 222

Query: 626 QHD-FSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEK-YQLHLHESCVLSLKFASCG 683
            +   S  +  +   P+ ++L        ++IL + +    Y L  H   V ++ F+  G
Sbjct: 223 HYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGG 282

Query: 684 RWFVSTGKDNLLNAWRTPY 702
             F S G D  +  WRT +
Sbjct: 283 ELFASGGADTQVLLWRTNF 301



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 45/212 (21%), Positives = 90/212 (42%), Gaps = 3/212 (1%)

Query: 533 AAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGA 592
           A   P ++        A  +L +SP+ K   +   D  +++W+ +      ++ GH D  
Sbjct: 4   ATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVV 63

Query: 593 SCIDISDYGTRLWTGGLDNTVRCW-DLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMES 651
           + +  S +G  L +   D TVR W   + G+  +    ++ + S+    +  +LA   E 
Sbjct: 64  TSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASED 123

Query: 652 SNVEILHV-RKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSK 710
            ++++  + R+   Y L+ H   V   KF+  GR  VS  +D  +  W T     +    
Sbjct: 124 KSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS 183

Query: 711 ESSSVLS-CDISRNNKYIVTGSGDKKATVYEV 741
           +S    +  D + +   I +   D+   V++V
Sbjct: 184 DSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 73/304 (24%), Positives = 126/304 (41%), Gaps = 21/304 (6%)

Query: 449 RQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLN-RDNYIR 507
           RQ H L  G    A +  G+ Q   T G     +   G P   +  A +  L+  +  + 
Sbjct: 19  RQRHELLLG----AGSGPGAGQQQATPGA----LLQAGPPRCSSLQAPIMLLSGHEGEVY 70

Query: 508 SCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCS 567
            CK  P+G +L   G    + +W++        A L   + A   L  + D  + FS  +
Sbjct: 71  CCKFHPNGSTLASAGFDRLILLWNVYGDCDNY-ATLKGHSGAVMELHYNTDGSMLFSAST 129

Query: 568 DGNIVVWDLQNQTMVRQFQGHTDGA-SCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 626
           D  + VWD +    V++ +GHT    SC         + TG  D TV+ WD+R+   +Q 
Sbjct: 130 DKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT 189

Query: 627 HDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFASCGRW 685
              + Q+ ++      D +  G   +++++  +R+ +  Y +  H   V  L  +S G +
Sbjct: 190 FQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSY 249

Query: 686 FVSTGKDNLLNAWRT-PYG-----ASIFQSKE---SSSVLSCDISRNNKYIVTGSGDKKA 736
            +S   DN +  W   P+        IFQ        ++L C  S +   I  GS D+  
Sbjct: 250 LLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFV 309

Query: 737 TVYE 740
            V++
Sbjct: 310 YVWD 313



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 29/150 (19%), Positives = 60/150 (40%), Gaps = 12/150 (8%)

Query: 446 RHARQLHTLAHGEVVCAVTISGSTQHVYTGG-KGCVKVWDVGQPGAKTPVAQLDCLNRDN 504
           R    + T  +   V AVT + ++  + +GG    +KVWD+ Q      +         +
Sbjct: 182 RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR-----GHAD 236

Query: 505 YIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPR------IKAELTSSAPACYALAVSPD 558
            +    L  +G  L+     +T+ +WD+    P+       +  + +        + SPD
Sbjct: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296

Query: 559 AKVCFSCCSDGNIVVWDLQNQTMVRQFQGH 588
                +  +D  + VWD  ++ ++ +  GH
Sbjct: 297 GSKIAAGSADRFVYVWDTTSRRILYKLPGH 326


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 74/290 (25%), Positives = 116/290 (40%), Gaps = 23/290 (7%)

Query: 456 HGEVVCAVTISGSTQHVYTGGK-GCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 514
           HG  V +   S   Q + TG + GCV  W+         +           ++ C+  PD
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG-----GHTGPVKFCRFSPD 74

Query: 515 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVW 574
           G          T+ +WD+A    +    L     +   ++ SPD++   S   D  +++W
Sbjct: 75  GHLFASASCDCTVRLWDVARA--KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLW 132

Query: 575 DLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIF 634
           D+Q+  M+R   GH D     D S     L TG  D+TV  WDLR       H       
Sbjct: 133 DVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE--- 189

Query: 635 SLGHCPNQDWL---AVGMESSNV--EILHVRKPEK----YQLHLHESCVLSLKFASCGRW 685
             GH  N   L   A G+ +S    + +H+ KP       QL  H + V S+ F+    W
Sbjct: 190 --GHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELW 247

Query: 686 FVSTGKDNLLNAWRTPYGASIFQSKESSSVL-SCDISRNNKYIVTGSGDK 734
             S G   ++  W    G  +   K    V  +C  + + K +V+G+ D+
Sbjct: 248 LASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297



 Score = 31.2 bits (69), Expect = 3.6
 Identities = 36/163 (22%), Positives = 60/163 (36%), Gaps = 3/163 (1%)

Query: 582 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQL-QQHDFSSQIFSLGHCP 640
           V+ F  H    +    S  G  L TG  D  V  W+ R G+ L +    +  +      P
Sbjct: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73

Query: 641 NQDWLAVGMESSNVEILHVRKPEKYQ-LHLHESCVLSLKFASCGRWFVSTGKDNLLNAWR 699
           +    A       V +  V + +  + L  H+  V ++ F+   R   S G D  +  W 
Sbjct: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133

Query: 700 TPYGASI-FQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEV 741
              G  +        S+ S D S     + TGS D    ++++
Sbjct: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176



 Score = 30.8 bits (68), Expect = 4.8
 Identities = 48/202 (23%), Positives = 69/202 (34%), Gaps = 48/202 (23%)

Query: 456 HGEVVCAVTISGSTQHVYTGG-KGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 514
           H   V  V+ S  ++ + +GG    V +WDV Q G    + +L   +RD+ I+S    P 
Sbjct: 104 HQRSVETVSFSPDSRQLASGGWDKRVMLWDV-QSGQ---MLRLLVGHRDS-IQSSDFSPT 158

Query: 515 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPA-----CYA----------------- 552
              L  G   ST+ IWDL   TP +  +      A     CY+                 
Sbjct: 159 VNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIW 218

Query: 553 --------------------LAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGA 592
                               +A SPD     S      + VWD      +   +G  D A
Sbjct: 219 KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVA 278

Query: 593 SCIDISDYGTRLWTGGLDNTVR 614
                +  G  L +G  D T R
Sbjct: 279 HTCAFTPDGKILVSGAADQTRR 300


>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
           isoform a [Homo sapiens]
          Length = 353

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 68/299 (22%), Positives = 126/299 (42%), Gaps = 23/299 (7%)

Query: 456 HG-EVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 514
           HG +V+C        + V +   G V VWD      +  V  + C     ++ +C   P 
Sbjct: 62  HGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVT-MPC----TWVMACAYAPS 116

Query: 515 GRSLIVGGEASTLSIWDLA-------APTPRIKAELTSSAPACYALAVSPDAKVCFSCCS 567
           G ++  GG  +  S++ L        A   +  A  T+   AC     + D ++  +   
Sbjct: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF--TNSDMQI-LTASG 173

Query: 568 DGNIVVWDLQNQTMVRQFQGHTDGASCIDI--SDYGTRLWTGGLDNTVRCWDLREGRQLQ 625
           DG   +WD+++  +++ F GH     C+D+  S+ G    +GG D     WD+R G+ +Q
Sbjct: 174 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 233

Query: 626 QHD-FSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVL---SLKFAS 681
             +   S I S+ + P+ D  A G + +   +  +R   +  ++  ES +    S+ F+ 
Sbjct: 234 AFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSL 293

Query: 682 CGRWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISRNNKYIVTGSGDKKATVY 739
            GR   +   D  +N W    G+ +       + V +  +S +     +GS D    V+
Sbjct: 294 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352


>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
           isoform b [Homo sapiens]
          Length = 395

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 68/299 (22%), Positives = 126/299 (42%), Gaps = 23/299 (7%)

Query: 456 HG-EVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 514
           HG +V+C        + V +   G V VWD      +  V  + C     ++ +C   P 
Sbjct: 104 HGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVT-MPC----TWVMACAYAPS 158

Query: 515 GRSLIVGGEASTLSIWDLA-------APTPRIKAELTSSAPACYALAVSPDAKVCFSCCS 567
           G ++  GG  +  S++ L        A   +  A  T+   AC     + D ++  +   
Sbjct: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF--TNSDMQI-LTASG 215

Query: 568 DGNIVVWDLQNQTMVRQFQGHTDGASCIDI--SDYGTRLWTGGLDNTVRCWDLREGRQLQ 625
           DG   +WD+++  +++ F GH     C+D+  S+ G    +GG D     WD+R G+ +Q
Sbjct: 216 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 275

Query: 626 QHD-FSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVL---SLKFAS 681
             +   S I S+ + P+ D  A G + +   +  +R   +  ++  ES +    S+ F+ 
Sbjct: 276 AFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSL 335

Query: 682 CGRWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISRNNKYIVTGSGDKKATVY 739
            GR   +   D  +N W    G+ +       + V +  +S +     +GS D    V+
Sbjct: 336 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394


>gi|5174447 guanine nucleotide binding protein (G protein), beta
           polypeptide 2-like 1 [Homo sapiens]
          Length = 317

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 65/272 (23%), Positives = 108/272 (39%), Gaps = 20/272 (7%)

Query: 443 GIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGG-KGCVKVWDVGQPGAKTPVAQLDCLN 501
           GIP+ A +     H   V  V IS   Q   +G   G +++WD+      T       + 
Sbjct: 53  GIPQRALR----GHSHFVSDVVISSDGQFALSGSWDGTLRLWDL-----TTGTTTRRFVG 103

Query: 502 RDNYIRSCKLLPDGRSLIVGGEASTLSIWD-LAAPTPRIKAELTSSAPACYALAVSPDAK 560
               + S     D R ++ G    T+ +W+ L      ++ E  S   +C   + +    
Sbjct: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNP 163

Query: 561 VCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLRE 620
           +  SC  D  + VW+L N  +     GHT   + + +S  G+   +GG D     WDL E
Sbjct: 164 IIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE 223

Query: 621 GRQLQQHDFSSQIFSLGHCPNQDWLAVGMESS----NVEILHVRKPEKYQLHLHESCV-- 674
           G+ L   D    I +L   PN+ WL      S    ++E   +    K ++    S    
Sbjct: 224 GKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283

Query: 675 ---LSLKFASCGRWFVSTGKDNLLNAWRTPYG 703
               SL +++ G+   +   DNL+  W+   G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 62/289 (21%), Positives = 110/289 (38%), Gaps = 37/289 (12%)

Query: 488 PGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAE----- 542
           P + T +      N +  + + ++ PD + L  G + S + +W L +   ++K+E     
Sbjct: 253 PPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSK--KLKSEPHQVD 310

Query: 543 ---------------------------LTSSAPACYALAVSPDAKVCFSCCSDGNIVVWD 575
                                      L       Y+     D+    SC  D +I  WD
Sbjct: 311 VSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWD 370

Query: 576 LQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQH-DFSSQIF 634
           L + T    +QGH      +DIS Y     +G  D T R W       L+ +    + + 
Sbjct: 371 LGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVD 430

Query: 635 SLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHL-HESCVLSLKFASCGRWFVSTGKDN 693
            +   PN ++LA G     V +   ++    +L   H   VLSL F+  G++  S G+D 
Sbjct: 431 CVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ 490

Query: 694 LLNAWRTPYGASIFQSK-ESSSVLSCDISRNNKYIVTGSGDKKATVYEV 741
            L  W    G    + +  + ++ S   S ++  I + S D    V+++
Sbjct: 491 RLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 34/126 (26%), Positives = 57/126 (45%), Gaps = 11/126 (8%)

Query: 494 VAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYAL 553
           +A +DC+         K  P+   L  G    T+ +W  +A         T       +L
Sbjct: 426 LADVDCV---------KFHPNSNYLATGSTDKTVRLW--SAQQGNSVRLFTGHRGPVLSL 474

Query: 554 AVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTV 613
           A SP+ K   S   D  + +WDL + T+ ++ +GHTD  + +  S     + +  +DN+V
Sbjct: 475 AFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSV 534

Query: 614 RCWDLR 619
           R WD+R
Sbjct: 535 RVWDIR 540



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 24/73 (32%), Positives = 37/73 (50%), Gaps = 2/73 (2%)

Query: 506 IRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSC 565
           + S    P+G+ L   GE   L +WDLA+ T  +  EL        +L  SPD+ +  S 
Sbjct: 471 VLSLAFSPNGKYLASAGEDQRLKLWDLASGT--LYKELRGHTDNITSLTFSPDSGLIASA 528

Query: 566 CSDGNIVVWDLQN 578
             D ++ VWD++N
Sbjct: 529 SMDNSVRVWDIRN 541


>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
          Length = 404

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 64/277 (23%), Positives = 108/277 (38%), Gaps = 43/277 (15%)

Query: 458 EVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRS 517
           +V C V  +G          G +K+W+V     +T +  L+     + +R     P G  
Sbjct: 120 DVSCLVLATGLND-------GQIKIWEV-----QTGLLLLNLSGHQDVVRDLSFTPSGSL 167

Query: 518 LIVGGEAS-TLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDL 576
           ++V      TL IWDL     +I+  L+      Y  ++SPD  +  S   + ++ +W +
Sbjct: 168 ILVSASRDKTLRIWDLNKHGKQIQV-LSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSM 226

Query: 577 QNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSL 636
           ++ T++R+ +GH       D S     L T   D  V  WD   G +L+         SL
Sbjct: 227 RSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLR---------SL 277

Query: 637 GHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLN 696
            H      +   M+ S+V               H S + S+ F+  G +  +   D LL 
Sbjct: 278 HHTQ----VDPAMDDSDV---------------HISSLRSVCFSPEGLYLATVADDRLLR 318

Query: 697 AWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGD 733
            W       I  +  ++  L C    +   I TG+ D
Sbjct: 319 IWALELKTPIAFAPMTNG-LCCTFFPHGGVIATGTRD 354


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 54/213 (25%), Positives = 92/213 (43%), Gaps = 6/213 (2%)

Query: 526 TLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQF 585
           ++ +W L +  P   A++         +   P  +   + C D +  +WDL+ Q  +   
Sbjct: 304 SVKLWSLDSDEP--VADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQ 361

Query: 586 QGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQ-QHDFSSQIFSLGHCPNQDW 644
           +GH+ G   I     G+   TGGLD   R WDLR GR +        +I+ +   PN   
Sbjct: 362 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYH 421

Query: 645 LAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFASCGRWFVSTGK-DNLLNAWRTPY 702
           +A G   +  ++  +R+    Y +  H++ V  +KF      F+ TG  DN    W  P 
Sbjct: 422 IATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPG 481

Query: 703 GASI-FQSKESSSVLSCDISRNNKYIVTGSGDK 734
            + +   +     V+  DIS + + I T S D+
Sbjct: 482 WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDR 514



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 52/248 (20%), Positives = 78/248 (31%), Gaps = 51/248 (20%)

Query: 503 DNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVC 562
           D  I  C   P+ + L     +    +W +  P   +   L        A+   P + V 
Sbjct: 231 DRPISYCHFSPNSKMLATACWSGLCKLWSV--PDCNLLHTLRGHNTNVGAIVFHPKSTVS 288

Query: 563 F--------SCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVR 614
                    SC +DG++ +W L +   V   +GHT   + +     G  L T   D + R
Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348

Query: 615 CWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCV 674
            WDL                                 +  EILH           H   V
Sbjct: 349 LWDLE--------------------------------AQEEILHQEG--------HSMGV 368

Query: 675 LSLKFASCGRWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISRNNKYIVTGSGD 733
             + F   G    + G D     W    G  I F       +   + S N  +I TGSGD
Sbjct: 369 YDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGD 428

Query: 734 KKATVYEV 741
               V+++
Sbjct: 429 NTCKVWDL 436


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 48/211 (22%), Positives = 92/211 (43%), Gaps = 10/211 (4%)

Query: 454 LAHGEVVCAVTIS-GSTQHVYTGGKGC-VKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKL 511
           +AH   V ++ +   S + + TGG  C V +W + +P        +      + + S +L
Sbjct: 17  VAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCI-----MSLTGHTSPVESVRL 71

Query: 512 LPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNI 571
                 ++ G ++ ++ +WDL A   +I   L        +L   P  +   S   D NI
Sbjct: 72  NTPEELIVAGSQSGSIRVWDLEAA--KILRTLMGHKANICSLDFHPYGEFVASGSQDTNI 129

Query: 572 VVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQH-DFS 630
            +WD++ +  V +++GH+    C+  S  G  L +   D+TV+ WDL  G+ + +    +
Sbjct: 130 KLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189

Query: 631 SQIFSLGHCPNQDWLAVGMESSNVEILHVRK 661
             +  +   PN+  LA G     +    + K
Sbjct: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 34/177 (19%), Positives = 77/177 (43%), Gaps = 3/177 (1%)

Query: 568 DGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ- 626
           D  + +W +     +    GHT     + ++     +  G    ++R WDL   + L+  
Sbjct: 42  DCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTL 101

Query: 627 HDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFASCGRW 685
               + I SL   P  +++A G + +N+++  +R+    ++   H   V  L+F+  G+W
Sbjct: 102 MGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKW 161

Query: 686 FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIV-TGSGDKKATVYEV 741
             S   D+ +  W    G  + +    +  ++      N+Y++ +GS D+    +++
Sbjct: 162 LASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218


>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
           sapiens]
          Length = 340

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 57/249 (22%), Positives = 99/249 (39%), Gaps = 28/249 (11%)

Query: 502 RDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKV 561
           R +++ +C   P G  +  GG  +  SI++L +    +K     SA   Y          
Sbjct: 96  RSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGY---------- 145

Query: 562 CFSCC---SDGNIV---------VWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGL 609
             SCC    D NIV         +WD++       F GHT     + +S       +G  
Sbjct: 146 -LSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGAC 204

Query: 610 DNTVRCWDLREGRQLQQH-DFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLH 668
           D + + WD+REG   Q      S I ++   PN + +  G + ++  +  +R  ++    
Sbjct: 205 DASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICF 264

Query: 669 LHESC---VLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSC-DISRNN 724
            HES    + S+ F+  GR   +   D   N W +     +       + +SC  ++ + 
Sbjct: 265 SHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADG 324

Query: 725 KYIVTGSGD 733
             + TGS D
Sbjct: 325 MAVATGSWD 333



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 50/198 (25%), Positives = 82/198 (41%), Gaps = 7/198 (3%)

Query: 505 YIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFS 564
           Y+  C+ L D   +   G+ +T ++WD+   T + K         C +LAVSPD  +  S
Sbjct: 145 YLSCCRFLDDNNIVTSSGD-TTCALWDIE--TGQQKTVFVGHTGDCMSLAVSPDFNLFIS 201

Query: 565 CCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQL 624
              D +  +WD++  T  + F GH    + I     G  + TG  D + R +DLR  ++L
Sbjct: 202 GACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQEL 261

Query: 625 ---QQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQ-LHLHESCVLSLKFA 680
                      I S+    +   L  G +  N  +    K E+   L  H++ V  L   
Sbjct: 262 ICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVT 321

Query: 681 SCGRWFVSTGKDNLLNAW 698
           + G    +   D+ L  W
Sbjct: 322 ADGMAVATGSWDSFLKIW 339



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 31/137 (22%), Positives = 59/137 (43%), Gaps = 5/137 (3%)

Query: 481 KVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIK 540
           K+WDV +   +           ++ I +    P+G ++  G + ++  ++DL A    I 
Sbjct: 209 KLWDVREGTCRQTFT-----GHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELIC 263

Query: 541 AELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDY 600
               S      ++A S   ++ F+   D N  VWD      V    GH +  SC+ ++  
Sbjct: 264 FSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTAD 323

Query: 601 GTRLWTGGLDNTVRCWD 617
           G  + TG  D+ ++ W+
Sbjct: 324 GMAVATGSWDSFLKIWN 340



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 44/211 (20%), Positives = 76/211 (36%), Gaps = 8/211 (3%)

Query: 538 RIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDI 597
           R +  L       YA+  + D+K+  S   DG ++VWD      V      +        
Sbjct: 46  RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY 105

Query: 598 SDYGTRLWTGGLDNTVRCWDL--REGRQLQQHDFSSQIFSLGHCP--NQDWLAVGMESSN 653
           +  G  +  GGLDN    ++L  REG      + S+    L  C   + + +      + 
Sbjct: 106 APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTT 165

Query: 654 VEILHVRKPEKYQLHL-HESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGA--SIFQSK 710
             +  +   ++  + + H    +SL  +     F+S   D     W    G     F   
Sbjct: 166 CALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGH 225

Query: 711 ESSSVLSCDISRNNKYIVTGSGDKKATVYEV 741
           ES     C    N + I TGS D    ++++
Sbjct: 226 ESDINAIC-FFPNGEAICTGSDDASCRLFDL 255


>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
           sapiens]
          Length = 421

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 64/261 (24%), Positives = 97/261 (37%), Gaps = 43/261 (16%)

Query: 478 GCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEAS-TLSIWDLAAPT 536
           G +K+WDV      T    L+ ++    +R     PDG  ++V      TL +WDL    
Sbjct: 150 GRIKIWDV-----YTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDG 204

Query: 537 PRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCID 596
             +K  L       Y+ A SPD+ +  S  +   + +W++   TM+R+ +GH       D
Sbjct: 205 NMMKV-LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACD 263

Query: 597 ISDYGTRLWTGGLDNTVRCWDLREGRQLQQ--HDF--SSQIFSLGHCPNQDWLAVGMESS 652
            S  G  L T   D  V  WD   G  L +  H F   + IF+ G   N  W        
Sbjct: 264 FSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGG--ANDRW-------- 313

Query: 653 NVEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKES 712
                                V S+ F+  G    S   D ++  WR      + Q    
Sbjct: 314 ---------------------VRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPL 351

Query: 713 SSVLSCDISRNNKYIVTGSGD 733
           S+ L C  S +   +  G+ D
Sbjct: 352 SNGLCCAFSTDGSVLAAGTHD 372



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 36/140 (25%), Positives = 58/140 (41%), Gaps = 9/140 (6%)

Query: 451 LHTLAHGEVVCAVTIS--GSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRS 508
           L+ + H EVV  +T +  GS   V       ++VWD+   G    V +       N++ S
Sbjct: 164 LNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLR----GHQNWVYS 219

Query: 509 CKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSD 568
           C   PD   L   G +  + +W++   T   K E         A   SPD  +  +   D
Sbjct: 220 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE--GHHHDVVACDFSPDGALLATASYD 277

Query: 569 GNIVVWDLQNQTMVRQFQGH 588
             + +WD  N  ++ +F GH
Sbjct: 278 TRVYIWDPHNGDILMEF-GH 296


>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
           [Homo sapiens]
          Length = 340

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 52/239 (21%), Positives = 97/239 (40%), Gaps = 8/239 (3%)

Query: 502 RDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAA--PTPRIKAELTSSAPACYALAVSPDA 559
           R +++ +C   P G  +  GG  +  SI++L       R+  EL              D+
Sbjct: 96  RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDS 155

Query: 560 KVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLR 619
           ++  S   D    +WD++       F GH+     + +S       +G  D + + WD+R
Sbjct: 156 QIVTS-SGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIR 214

Query: 620 EGRQLQQH-DFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESC---VL 675
           +G   Q      S I ++   PN    A G + +   +  +R  ++  L+ H++    + 
Sbjct: 215 DGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGIT 274

Query: 676 SLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSC-DISRNNKYIVTGSGD 733
           S+ F+  GR  ++   D   N W T  G          + +SC  ++ +   + TGS D
Sbjct: 275 SVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 47/198 (23%), Positives = 83/198 (41%), Gaps = 7/198 (3%)

Query: 505 YIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFS 564
           Y+  C+ L D + +   G+ +T ++WD+   T +     T  +    +L++SPD +   S
Sbjct: 145 YLSCCRFLDDSQIVTSSGD-TTCALWDIE--TAQQTTTFTGHSGDVMSLSLSPDMRTFVS 201

Query: 565 CCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQ- 623
              D +  +WD+++    + F GH    + +     G    TG  D T R +DLR  ++ 
Sbjct: 202 GACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQEL 261

Query: 624 -LQQHD-FSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKY-QLHLHESCVLSLKFA 680
            L  HD     I S+    +   L  G +  N  +    K ++   L  H++ V  L   
Sbjct: 262 LLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVT 321

Query: 681 SCGRWFVSTGKDNLLNAW 698
             G    +   D+ L  W
Sbjct: 322 DDGMAVATGSWDSFLRIW 339



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 29/137 (21%), Positives = 57/137 (41%), Gaps = 5/137 (3%)

Query: 481 KVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIK 540
           K+WD+     +  + +       + I +    P+G +   G + +T  ++DL A    + 
Sbjct: 209 KLWDI-----RDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLL 263

Query: 541 AELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDY 600
               +      ++A S   ++  +   D N  VWD           GH +  SC+ ++D 
Sbjct: 264 YSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDD 323

Query: 601 GTRLWTGGLDNTVRCWD 617
           G  + TG  D+ +R W+
Sbjct: 324 GMAVATGSWDSFLRIWN 340



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 39/210 (18%), Positives = 70/210 (33%), Gaps = 6/210 (2%)

Query: 538 RIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDI 597
           R +  L       YA+    D+++  S   DG +++WD      +      +        
Sbjct: 46  RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAY 105

Query: 598 SDYGTRLWTGGLDNTVRCWDL--REGRQLQQHDFSSQIFSLGHCP--NQDWLAVGMESSN 653
           +  G  +  GGLDN    ++L  REG      +       L  C   +   +      + 
Sbjct: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTT 165

Query: 654 VEILHVRKPEKYQLHL-HESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQ-SKE 711
             +  +   ++      H   V+SL  +   R FVS   D     W    G      +  
Sbjct: 166 CALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGH 225

Query: 712 SSSVLSCDISRNNKYIVTGSGDKKATVYEV 741
            S + +     N     TGS D    ++++
Sbjct: 226 VSDINAVSFFPNGYAFATGSDDATCRLFDL 255


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 64/270 (23%), Positives = 103/270 (38%), Gaps = 49/270 (18%)

Query: 514 DGRSLIVGGEA-STLSIWDLAAPT---------------------PRIKAELTSS----- 546
           D  SLI GG A ST+ +W +                          RI  E T+S     
Sbjct: 480 DDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKIL 539

Query: 547 ---APACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTR 603
              +   Y  + SPD     S   DG + +W LQ  T +  ++GH         S YG  
Sbjct: 540 YGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYY 599

Query: 604 LWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHC---------PNQDWLAVGMESSNV 654
             +GG D   R W          H    +IF+ GH          PN +++A G     V
Sbjct: 600 FVSGGHDRVARLW-------ATDHYQPLRIFA-GHLADVNCTRFHPNSNYVATGSADRTV 651

Query: 655 EILHVRKPEKYQLHL-HESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSK-ES 712
            +  V      ++   H+  + SL F+  GR+  +   D  +  W   +G  + + K  +
Sbjct: 652 RLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHT 711

Query: 713 SSVLSCDISRNNKYIVTGSGDKKATVYEVV 742
            +V S   SR+ + + +GS D    +++ +
Sbjct: 712 DTVCSLRFSRDGEILASGSMDNTVRLWDAI 741



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 39/138 (28%), Positives = 66/138 (47%), Gaps = 5/138 (3%)

Query: 513 PDGRSLIVGGEASTLSIWD-LAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNI 571
           P+   +  G    T+ +WD L     RI    T      ++L  SP+ +   +  +DG +
Sbjct: 637 PNSNYVATGSADRTVRLWDVLNGNCVRI---FTGHKGPIHSLTFSPNGRFLATGATDGRV 693

Query: 572 VVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD-LREGRQLQQHDFS 630
           ++WD+ +  MV + +GHTD    +  S  G  L +G +DNTVR WD ++    L+  DF+
Sbjct: 694 LLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFT 753

Query: 631 SQIFSLGHCPNQDWLAVG 648
           +    +    N   L +G
Sbjct: 754 TATGHINLPENSQELLLG 771



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 35/186 (18%), Positives = 74/186 (39%), Gaps = 34/186 (18%)

Query: 591 GASCIDISDYGTRLWTGGLDNTVRCWDL--REGRQLQQ---------------------- 626
           G + +D++D  + +  G  D+TVR W +  ++ R ++Q                      
Sbjct: 472 GLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEK 531

Query: 627 --------HDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHL-HESCVLSL 677
                   +  S  ++     P++++L    E   V +  ++       +  H   V   
Sbjct: 532 TASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDT 591

Query: 678 KFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCD-ISRNNKYIVTGSGDKKA 736
           +F+  G +FVS G D +   W T +   +       + ++C     N+ Y+ TGS D+  
Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTV 651

Query: 737 TVYEVV 742
            +++V+
Sbjct: 652 RLWDVL 657


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,869,622
Number of Sequences: 37866
Number of extensions: 1907040
Number of successful extensions: 11115
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 195
Number of HSP's successfully gapped in prelim test: 720
Number of HSP's that attempted gapping in prelim test: 8348
Number of HSP's gapped (non-prelim): 2733
length of query: 743
length of database: 18,247,518
effective HSP length: 110
effective length of query: 633
effective length of database: 14,082,258
effective search space: 8914069314
effective search space used: 8914069314
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.