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Search of human proteins with 21359935
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
(2113 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 4271 0.0
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 2453 0.0
gi|222352127 sidekick 2 [Homo sapiens] 323 1e-87
gi|119220552 sidekick 1 [Homo sapiens] 289 2e-77
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 278 5e-74
gi|157311649 neogenin homolog 1 [Homo sapiens] 244 6e-64
gi|110349719 titin isoform N2-A [Homo sapiens] 241 7e-63
gi|4506569 roundabout 1 isoform a [Homo sapiens] 238 4e-62
gi|19743806 roundabout 1 isoform b [Homo sapiens] 237 8e-62
gi|118572606 hemicentin 1 [Homo sapiens] 235 3e-61
gi|224994173 roundabout 1 isoform d [Homo sapiens] 234 7e-61
gi|224994171 roundabout 1 isoform c [Homo sapiens] 234 7e-61
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 234 7e-61
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 234 7e-61
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 234 7e-61
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 232 3e-60
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 232 3e-60
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 229 2e-59
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 229 3e-59
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 228 4e-59
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 226 2e-58
gi|75709184 contactin 3 [Homo sapiens] 225 3e-58
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 224 7e-58
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 222 3e-57
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 222 3e-57
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 222 3e-57
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 216 2e-55
gi|4827022 contactin 2 precursor [Homo sapiens] 215 4e-55
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 214 5e-55
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 214 9e-55
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 4271 bits (11077), Expect = 0.0
Identities = 2113/2113 (100%), Positives = 2113/2113 (100%)
Query: 1 MTGAGEPRREEPPPQPSAGLRSRESGAPSAGGWERAERGRGAAARPATGPPPRRIGPLYG 60
MTGAGEPRREEPPPQPSAGLRSRESGAPSAGGWERAERGRGAAARPATGPPPRRIGPLYG
Sbjct: 1 MTGAGEPRREEPPPQPSAGLRSRESGAPSAGGWERAERGRGAAARPATGPPPRRIGPLYG 60
Query: 61 MWLVTFLLLLDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWY 120
MWLVTFLLLLDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWY
Sbjct: 61 MWLVTFLLLLDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWY 120
Query: 121 LATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVK 180
LATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVK
Sbjct: 121 LATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVK 180
Query: 181 AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHG 240
AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHG
Sbjct: 181 AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHG 240
Query: 241 GLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAG 300
GLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAG
Sbjct: 241 GLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAG 300
Query: 301 HTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGTYICEVTNTF 360
HTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGTYICEVTNTF
Sbjct: 301 HTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGTYICEVTNTF 360
Query: 361 GSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEA 420
GSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEA
Sbjct: 361 GSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEA 420
Query: 421 ISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVN 480
ISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVN
Sbjct: 421 ISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVN 480
Query: 481 PGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDG 540
PGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDG
Sbjct: 481 PGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDG 540
Query: 541 GVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYK 600
GVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYK
Sbjct: 541 GVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYK 600
Query: 601 DALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQ 660
DALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQ
Sbjct: 601 DALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQ 660
Query: 661 PFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVS 720
PFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVS
Sbjct: 661 PFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVS 720
Query: 721 LKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPK 780
LKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPK
Sbjct: 721 LKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPK 780
Query: 781 VMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKS 840
VMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKS
Sbjct: 781 VMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKS 840
Query: 841 MFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIA 900
MFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIA
Sbjct: 841 MFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIA 900
Query: 901 TKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKA 960
TKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKA
Sbjct: 901 TKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKA 960
Query: 961 RSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSI 1020
RSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSI
Sbjct: 961 RSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSI 1020
Query: 1021 RMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIR 1080
RMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIR
Sbjct: 1021 RMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIR 1080
Query: 1081 GYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSE 1140
GYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSE
Sbjct: 1081 GYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSE 1140
Query: 1141 INATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWG 1200
INATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWG
Sbjct: 1141 INATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWG 1200
Query: 1201 EMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAV 1260
EMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAV
Sbjct: 1201 EMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAV 1260
Query: 1261 PSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQ 1320
PSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQ
Sbjct: 1261 PSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQ 1320
Query: 1321 YLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPA 1380
YLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPA
Sbjct: 1321 YLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPA 1380
Query: 1381 VKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV 1440
VKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV
Sbjct: 1381 VKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV 1440
Query: 1441 QVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSF 1500
QVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSF
Sbjct: 1441 QVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSF 1500
Query: 1501 KLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNL 1560
KLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNL
Sbjct: 1501 KLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNL 1560
Query: 1561 QGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCG 1620
QGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCG
Sbjct: 1561 QGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCG 1620
Query: 1621 NETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFIVRKKRKEKR 1680
NETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFIVRKKRKEKR
Sbjct: 1621 NETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFIVRKKRKEKR 1680
Query: 1681 LKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEGIKQLGDDKA 1740
LKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEGIKQLGDDKA
Sbjct: 1681 LKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEGIKQLGDDKA 1740
Query: 1741 TIPVTDAEFSQAVNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGTNPVSRKNVKSAHST 1800
TIPVTDAEFSQAVNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGTNPVSRKNVKSAHST
Sbjct: 1741 TIPVTDAEFSQAVNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGTNPVSRKNVKSAHST 1800
Query: 1801 RNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDTDKGRNSMVS 1860
RNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDTDKGRNSMVS
Sbjct: 1801 RNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDTDKGRNSMVS 1860
Query: 1861 TESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNENADSMTSMST 1920
TESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNENADSMTSMST
Sbjct: 1861 TESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNENADSMTSMST 1920
Query: 1921 PSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFFRKADGREPC 1980
PSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFFRKADGREPC
Sbjct: 1921 PSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFFRKADGREPC 1980
Query: 1981 PVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHPGAPAAASTATLPQRTLAMPAPP 2040
PVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHPGAPAAASTATLPQRTLAMPAPP
Sbjct: 1981 PVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHPGAPAAASTATLPQRTLAMPAPP 2040
Query: 2041 AGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMSTSGVGRSQK 2100
AGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMSTSGVGRSQK
Sbjct: 2041 AGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMSTSGVGRSQK 2100
Query: 2101 QGAGAYSKSYTLV 2113
QGAGAYSKSYTLV
Sbjct: 2101 QGAGAYSKSYTLV 2113
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 2453 bits (6357), Expect = 0.0
Identities = 1227/2073 (59%), Positives = 1540/2073 (74%), Gaps = 81/2073 (3%)
Query: 61 MWLVTFLLLLDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWY 120
MW++ L L S ED+ +SLYFVN SLQ+V F+S+ G +VPCPAAG P LRWY
Sbjct: 1 MWILA-LSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWY 59
Query: 121 LATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVK 180
LATG++IYDVP IRHVH NGTLQ++PF PS+F++ IHDN Y+CTAEN +GKIRS ++ +K
Sbjct: 60 LATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIK 119
Query: 181 AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHG 240
AV REPYTVRVEDQ++MRGNVAVFKC+IPSSV+ Y++VVSWEKDTVS++ RF IT G
Sbjct: 120 AVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTG 179
Query: 241 GLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAG 300
LYI DVQ ED L YRCIT+H+Y+GETRQSN ARL V+DPA S P+ILDGF ++ AG
Sbjct: 180 ALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAG 239
Query: 301 HTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGTYICEVTNTF 360
VELPC A G+P P RWLKD PL R+ K +TGL I ++R DSG+Y+CEV+N +
Sbjct: 240 QRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRY 299
Query: 361 GSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEA 420
G+A+ G L V PL T++P+K+K+ +GS V LSC++TG+ + + WYRN E++ P +
Sbjct: 300 GTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN 359
Query: 421 ISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVN 480
+ I G+++E L++ KS GAYQCF + +AQD+ + LEDGTP+I+S+FSEKVV+
Sbjct: 360 VRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVS 419
Query: 481 PGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDG 540
P E SLMC KG P PT+TW LDD+PI++ GSHR +Q S+G +S++N++ Q+RDG
Sbjct: 420 PAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDG 479
Query: 541 GVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYK 600
GVYRCTA N G YQARINVRGP SIR M+NITA+AGRDT I+CRVIGYPYYSIKWYK
Sbjct: 480 GVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYK 539
Query: 601 DALLLPDNHRQVVFE-NGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLI 659
++ LLP NHRQV FE NGTLKL+DVQK +DEGEY C+VL+QPQLS SQSVHV VKVPP I
Sbjct: 540 NSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFI 599
Query: 660 QPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSV 719
QPFEFP SIGQ ++IPCVV SGD+PI ITW+KDG+ I GVTI++ +F SSL+IS++
Sbjct: 600 QPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNL 659
Query: 720 SLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPP 779
SL HNGNYTCIA N AA V + QLIVRVPP+FVVQP +QDGIYGKA +LNCS +GYP P
Sbjct: 660 SLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVP 719
Query: 780 KVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISK 839
++WK +KG+G P Q+ P+ L GRIQ+L N SLLI+HV+EED GYYLC+ SN VG D+SK
Sbjct: 720 TIVWKFSKGAGVP-QFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSK 778
Query: 840 SMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAI 899
SM+LTVKIPAMITS+PNTT+A +G KE++CTA GE+PII+RWEK D +I+P+ + RY +
Sbjct: 779 SMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPE-MARYLV 837
Query: 900 ATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVK 959
+TK+ G+EV+STL++ P R DS FFSCHAINSYGEDRG+IQLTVQEPPDPPE+EI++VK
Sbjct: 838 STKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVK 897
Query: 960 ARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYS 1019
AR++ LRWT FDGNS ITG+DIE KNKSDSWD Q T+++SP +N A I+D+HP+S YS
Sbjct: 898 ARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYS 957
Query: 1020 IRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVI 1079
IRMY+ N+IG+SEPS ELTI+ +EAAPDGPP +V L+P++SQSI+VTWKAPKK LQNG+I
Sbjct: 958 IRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGII 1017
Query: 1080 RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSS 1139
RGYQIGYRE S G N Q++I+ + +GDSEVYTLDNL KF QYG+VVQA NRAGTGPSS
Sbjct: 1018 RGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ 1077
Query: 1140 EINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEW 1199
EI TTLEDVPS PPENV+A++ + + ISWS + LNG+L+G+RVI+W+ +DGE
Sbjct: 1078 EIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGEL 1137
Query: 1200 GEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKA 1259
GE++NITTT+ +EL G+EK+TNYS+QVLA+T+AGDGVRS ++ +TKEDVPGPPAG+KA
Sbjct: 1138 GEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKA 1197
Query: 1260 VPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQ 1319
+SAS V VSWLPP K NG+IRKYT+FCS P SE+E SP+ YRI +L+R +
Sbjct: 1198 AAASASMVFVSWLPPLKLNGIIRKYTVFCSHP--YPTVISEFEASPDSFSYRIPNLSRNR 1255
Query: 1320 QYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAP 1379
QY +WV AVTSAGRGNSSE +T+EP KAPA+I++F GTVTTPWMKD+ LPC +VGDP+P
Sbjct: 1256 QYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSP 1315
Query: 1380 AVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLL 1439
AVKW KDS + V++DG R I +NG+ ++R VKAEDSGYY+C A N G D II+NL
Sbjct: 1316 AVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQ 1375
Query: 1440 VQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERS 1499
VQVPPDQPRLTVSKT++SSITL+W+PGDNGGSSIRG++LQYS DNSE+W IS SERS
Sbjct: 1376 VQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERS 1435
Query: 1500 FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLN 1559
++L++LKCGTWYK L A+N VG GRISEIIEAKT G+EP FSK+Q LF IN+T RLN
Sbjct: 1436 YRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLN 1495
Query: 1560 LQGWNNGGCPITAIVLEYRPKGTWAW-QGLRANSSGEVFLTELREATWYELRMRACNSAG 1618
L GWN+GGCPIT+ LEYRP GT W R + S L +L+EATWYEL+MR CNSAG
Sbjct: 1496 LIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAG 1555
Query: 1619 CGNETAQFATLDYDGSTIPP-IKS-AQGE-----GDDVKKLFTIGCPVILATLGVALLFI 1671
C + A FATL+YDGSTIPP IKS Q E + +K L TI C ++ L LL +
Sbjct: 1556 CAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLLLFVLLLV 1615
Query: 1672 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEG 1731
VR++R+E+RLKRLRDAKSLAEML+SKN R+ DT K Q R+HIDIPR QLLIE+++
Sbjct: 1616 VRRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSK-QQQTLRMHIDIPRAQLLIEERDT 1674
Query: 1732 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGTNPVSR 1791
++ + DD++T+ +TDA+F +A +S ++H+ ++ Q+TGPL+D+SD RPGTNP +R
Sbjct: 1675 METI-DDRSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTR 1733
Query: 1792 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTV-TESDSYSASLSQD 1850
+N K+ + RNRY+SQWTL + + A TLT+DWR + +V ESDSYS S SQD
Sbjct: 1734 RNAKAGPTARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQD 1793
Query: 1851 TDKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNE 1910
TD+ R+SMVSTESASSTYEELARAYEHAK+EEQL+HAKF ITECFISD+SS+Q+T GTNE
Sbjct: 1794 TDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNE 1853
Query: 1911 NADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAF 1970
DS+TS STPSE GICRFTASPPKPQD R N+AVP HR D +LP Y + +
Sbjct: 1854 YTDSLTS-STPSESGICRFTASPPKPQDGGRVMNMAVPKAHR--PGDLIHLPPYLRMDFL 1910
Query: 1971 FRKADGREPCPVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHPGAPAAASTATLP 2030
+ G P + +L
Sbjct: 1911 LNR---------------------------------------------GGPGTSRDLSLG 1925
Query: 2031 QRTLAMPAPPAGTAPPAPGPTPAEPPTAPSAA-------PPAPSTEPPRAG---GPHTKM 2080
Q L P P P E ++ S+ P A +T P R G G KM
Sbjct: 1926 QACLEPQKSRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQREGAELGQAAKM 1985
Query: 2081 GGSRDSLLEMSTSGVGRSQKQGAGAYSKSYTLV 2113
S++SLL+ R +G Y+KSYTLV
Sbjct: 1986 SSSQESLLD------SRGHLKGNNPYAKSYTLV 2012
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 323 bits (828), Expect = 1e-87
Identities = 337/1312 (25%), Positives = 546/1312 (41%), Gaps = 145/1312 (11%)
Query: 389 GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCF- 447
G+ ++L+C GS +W N L ++ R +ITS ++H+G Y+C
Sbjct: 41 GNRLVLTCMAEGSWPLEFKWLHNNR-ELTKFSLEYR------YMITSLDRTHAGFYRCIV 93
Query: 448 -----ATRKAQTAQDFAII-ALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTW 501
A + QT A + + E+G S E V + + P P VTW
Sbjct: 94 RNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASF------PQPQVTW 147
Query: 502 ALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARI- 560
D I +++ ++ T+ ++ P D G Y A N ++
Sbjct: 148 FRDGRKIPP-----SSRIAITLENTLVILSTVAP---DAGRYYVQAVNDKNGDNKTSQPI 199
Query: 561 -----NVRGPPS------IRAMRNITAVAGR-DTLINCRVIGYPYYSIK--WYKDALLLP 606
NV GP I +N + VAG + + C P + W KD +LL
Sbjct: 200 TLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLS 259
Query: 607 ----DNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL--SISQSVHVAVKVPPLI- 659
D++R++ N T G D G Y C +++ S+ + +++V PP
Sbjct: 260 GGISDHNRRLTIPNPT--------GSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFV 311
Query: 660 -QPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISS 718
+P A + +++ IPC + G P ITW KD V+ +T + LQIS
Sbjct: 312 KEPERHITAEMEKVVDIPCQ-AKGVPPPSITWYKDAAVV-EVEKLTRFRQRNDGGLQISG 369
Query: 719 VSLKHNGNYTCIASNAAATVSRERQLIVR-VPPRFVVQPNNQDGIYGKAGVLNCSVDGYP 777
+ G + C A NAA V L V + P P + I G + VL C G P
Sbjct: 370 LVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAP 429
Query: 778 PPKVMWKHAK---GSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVG 834
P + W+ + SG+ Q PL + SLLI D G Y C A+N G
Sbjct: 430 RPAITWQKGERILASGSVQLPRFTPLE-------SGSLLISPTHISDAGTYTCLATNSRG 482
Query: 835 TDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIR--WEKGDTVIDPD 892
D S L V IT P IKG + C + + IR WEK + +
Sbjct: 483 VD-EASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTE 541
Query: 893 RVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPE 952
R I NG +L + GD ++C I++ G D L V++ P PE
Sbjct: 542 SHPR--IRLDRNG-----SLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPE 594
Query: 953 ---LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANI 1009
+ V+ R++NL WT+ FDGNS + + +E + W ++ + P +
Sbjct: 595 HPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLAS--VDPKATSVTV 652
Query: 1010 VDLHPASVYSIRMYSFNKIGRSEPSKELT-ISTEEAAPDGPPMDVTLQPVTSQSIQVTWK 1068
L PA Y R+ + N +G+ + SK+ +S E P PP +V T+QSI + W+
Sbjct: 653 KGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQ 712
Query: 1069 APKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQA 1128
P + QNG+++GY I Y Q+ + D L++L + Y + V A
Sbjct: 713 PPPESHQNGILKGYIIRYCLAGLPVGYQFKNI---TDADVNNLLLEDLIIWTNYEIEVAA 769
Query: 1129 FNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRV 1188
+N AG G SS++ TL+ VP+ PP NV A + S +W+ P +NG+ +GY++
Sbjct: 770 YNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKL 829
Query: 1189 IFWSLYVDGEWGEMQNITTTRERVE-------LRGMEKFTNYSVQVLAYTQAGDGVRSSV 1241
I W + E E + T R + + G++KFT Y VL +T GDG RS+
Sbjct: 830 IAW----EPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTP 885
Query: 1242 LYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEY 1301
++T EDVPGP + +S+ VSW P + NG++ Y I + Y
Sbjct: 886 QLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHY 945
Query: 1302 ETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGN-SSEKVTIEPAGKAPAKIISFGGTVT 1360
+ L YR+ L Y + VAA+TS G+G S+ ++ + P + G +
Sbjct: 946 LPN-VTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNI 1004
Query: 1361 TPWMKDVRLPCNSVGDPAPAV-KWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSG 1419
P + V L D ++ +W +++ + + + + R+++ D
Sbjct: 1005 GP--RSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLN 1062
Query: 1420 YYTCTATNTGGFDTIIVNLLVQVPPDQP----------------RLTVSKTSASSITLTW 1463
+TC + F VN++ PP QP +++ S +S+ L W
Sbjct: 1063 PFTCYS-----FRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRW 1117
Query: 1464 IP----GDNGGSSIRGFVLQYSVD--NSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAA 1517
+P NG G+ ++YS + + V ER + ++ L+ T Y+V++ A
Sbjct: 1118 MPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQA 1177
Query: 1518 KNSVGSGRISEIIEAKTHGREPSF--SKDQHLFTHINSTHARLNLQGWNNGGCPITAIVL 1575
N++GSG S+ + +T PS + L T +S R + + + +
Sbjct: 1178 FNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKV 1237
Query: 1576 EYRPKGT------WAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCGN 1621
Y+ K + W +G NSS LT L + YE+++ A G G+
Sbjct: 1238 MYKEKDSDTQPRFWLVEG---NSSRSAQLTGLGKYVLYEVQVLAFTRIGDGS 1286
Score = 218 bits (555), Expect = 5e-56
Identities = 356/1569 (22%), Positives = 598/1569 (38%), Gaps = 169/1569 (10%)
Query: 61 MW--LVTFLLLLDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALR 118
MW L+ LL L + AR +D S YF + ++ +V+ C A GS +
Sbjct: 1 MWGLLIWTLLALHQIRAARAQD-DVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFK 59
Query: 119 WYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFI---HDNDYFCTAENAAGKIRSP 175
W +H N L + + + H Y C N G +
Sbjct: 60 W----------------LHNNRELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQR 103
Query: 176 NIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFF 235
V+ + + + Q G AV + +S + V+W +D I P R
Sbjct: 104 QTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQ--PQVTWFRDGRKIPPSSRIA 161
Query: 236 ITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD---PAESI-PTILDG 291
IT L I DA Y K +G+ + S L+V + PA+ I PTI+
Sbjct: 162 ITLENTLVILSTVAPDAGRYYVQAVNDK-NGDNKTSQPITLTVENVGGPADPIAPTIIIP 220
Query: 292 FHSQEVWAGHT-VELPCTASGYPIPAIR--WLKDGRPLPADSRWTKRITGLTISDLRTED 348
+ V AG + V L C A+ P+ + W KDG L R LTI + D
Sbjct: 221 PKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNR--RLTIPNPTGSD 278
Query: 349 SGTYICEV---TNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVI-LSCALTGSPEF 404
+G Y CE +++ S L V++P P++ T V+ + C G P
Sbjct: 279 AGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPP 338
Query: 405 TIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALE 464
+I WY++ +V ++ R ++ L I+ +G +QCFA A Q +A+
Sbjct: 339 SITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVT 398
Query: 465 DGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYT-MSD 523
P I + V G L C GAP P +TW E I+ GS + ++T +
Sbjct: 399 SIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQ-KGERILASGSVQLPRFTPLES 457
Query: 524 GTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI-RAMRNITAVAGRDT 582
G+ + ++ I D G Y C A N G E A + V I + ++ + + G
Sbjct: 458 GSLL----ISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQA 513
Query: 583 LINCRVIGYPYYSIK--WYKD-ALLLPDNHRQVVFE-NGTLKLTDVQKGMDEGEYLCSVL 638
+ C V P +I+ W KD A L ++H ++ + NG+L ++ G D G Y C V
Sbjct: 514 SMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSG-DIGTYTCRV- 571
Query: 639 IQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRK--DG-- 694
I + S+S H+ V+ P E P A++ + I +TW K DG
Sbjct: 572 ISAGGNDSRSAHLRVRQLP--HAPEHPVATLSTV---------ERRAINLTWTKPFDGNS 620
Query: 695 ---QVIISGSGVTIESKEFMSSLQISSVSLKHNG-------NYTCIASNAAA----TVSR 740
+ I+ S ++S+ + S+ G + A N +
Sbjct: 621 PLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDT 680
Query: 741 ERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCS--VDGYPPPKVMWKHAKG--SGNPQQYH 796
ER + PP P N +G N S + PPP+ H G G +Y
Sbjct: 681 ERVSLPEEPP--TAPPQNVIA----SGRTNQSIMIQWQPPPE---SHQNGILKGYIIRYC 731
Query: 797 PVPLTGRIQILPNSSLLIRHVLEEDIGYYL-----CQASNGVGTDISKSMFLTVKIPAMI 851
L Q + + ++L ED+ + A N G + S + +
Sbjct: 732 LAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVP 791
Query: 852 TSHPNTTIAIKGHAKELNCTARGERPIIIRW-EKGDTVI--DPDRVMRYAIAT-KDNGDE 907
T P A ++ + T P I +G +I +P++ + T + N +
Sbjct: 792 TVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQD 851
Query: 908 VVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP----ELEIREVKARSM 963
+ + + F S + G+ V+ D P L E+ S+
Sbjct: 852 SIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSL 911
Query: 964 NLRWTQRFDGNSIITGFDIEYK--NKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIR 1021
+ W + + N I+TG+ I ++ N++++ + T + + + L + Y+I
Sbjct: 912 KVSWQEPGEKNGILTGYRISWEEYNRTNT----RVTHYLPNVTLEYRVTGLTALTTYTIE 967
Query: 1022 MYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRG 1081
+ + G+ + S S GPP ++ + + +S+ + ++ P + + + R
Sbjct: 968 VAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFR-PGYDGKTSISR- 1025
Query: 1082 YQIGYRENSPGSNGQYSIV-EMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSS 1139
+ + + G ++ ++ ++ D+ + +L F Y ++ N GT PS
Sbjct: 1026 WLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQP 1085
Query: 1140 EINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLK--GYRVIFWSLYVDG 1197
TL+ P P NV + + + W P NG + GY++ + DG
Sbjct: 1086 SRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKY--SRSDG 1143
Query: 1198 EWGEMQNITTTRERVE----LRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGP 1253
+ ++ ++RVE + +E++T Y VQV A+ G G S + +T+E VP
Sbjct: 1144 HGKTLSHV--VQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSS 1201
Query: 1254 -PAGIKAVPSSASSVVVSW--LPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFY 1310
P + A+ +++SS++V W +P NG++ Y + S
Sbjct: 1202 GPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSA 1261
Query: 1311 RIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPA---GKAPAKIISFGGTVTTPWMKDV 1367
++ L + Y + V A T G G+ S +E P I F TT V
Sbjct: 1262 QLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTT----SV 1317
Query: 1368 RLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTC---- 1423
RL + P A + I HRL T V A + YT
Sbjct: 1318 RL----IWQPPAA-------PNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLK 1366
Query: 1424 ---------TATNTGGFDTIIVNLLVQV-------PPDQPRLTVSKTSASSITLTWIPGD 1467
TA G+ L+V PP +P + A S+ L+W PG
Sbjct: 1367 PESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGS 1426
Query: 1468 NGGSSIRGFVLQYSVDNSEEW--KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGR 1525
+G S +R + +Q S W +S + SF +D LK T YK ++ A N +G
Sbjct: 1427 DGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSE 1486
Query: 1526 ISEIIEAKT 1534
SE E+ T
Sbjct: 1487 FSEESESLT 1495
Score = 184 bits (468), Expect = 6e-46
Identities = 186/739 (25%), Positives = 315/739 (42%), Gaps = 87/739 (11%)
Query: 947 PPDPPELEIREVKARSMNLRWTQRFDGNSIITGFDIEYK----NKSDSWDFKQSTRNISP 1002
P P L I + RS+ L++ +DG + I+ + +E + + + W N P
Sbjct: 993 PGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSN-EP 1051
Query: 1003 TINQANIVDLHPASVYSIRMYSFNKIGRSEPSK-ELTISTEEAAPDGPPMDVTLQPVTSQ 1061
+ DL+P + YS RM N +G S PS+ I T +A PD P +V+L+ +
Sbjct: 1052 DARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASET 1111
Query: 1062 SIQVTWKAPKKELQ---NGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKK 1118
S+ + W P E++ N GY+I Y + +V+ + D YT+++L++
Sbjct: 1112 SLWLRWM-PLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERD---YTIEDLEE 1167
Query: 1119 FAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRST 1178
+ +Y V VQAFN G+GP S + T E VPS P NV AL+ TS ++ WSE P +
Sbjct: 1168 WTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEAD 1227
Query: 1179 LNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVR 1238
NG++ GY+V++ D + + +L G+ K+ Y VQVLA+T+ GDG
Sbjct: 1228 RNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP 1287
Query: 1239 SSVLYIQ-TKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPA 1297
S ++ T +DVPGPP GI +SV + W PP PNG+I Y I +
Sbjct: 1288 SHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANT 1347
Query: 1298 PSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGG 1357
+ +P Y L YL + A T G G ++E + + + +
Sbjct: 1348 ATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQ------ 1401
Query: 1358 TVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPV---------------SMDGHRLI 1402
+ P ++ + SV + W S D PV ++ +
Sbjct: 1402 PPSRPMVQQEDVRARSV-----LLSWEPGS-DGLSPVRYYTIQTRELPSGRWALHSASVS 1455
Query: 1403 HTNGTLLLRAVKAEDSGYYTCTATNTGG-----FDTIIVNLLVQVPPDQPR-LTVSKTSA 1456
H + ++ +K S + ATN G ++ + L P + P L+V+ +
Sbjct: 1456 HNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTT 1515
Query: 1457 SSITLTWIPGD----NG-------------GSSIRGFVLQYSVDNSEEWKDVFISSSERS 1499
+S+ + W P NG +RGF L+ + W ++ S R+
Sbjct: 1516 TSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRN 1575
Query: 1500 --------FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI 1551
++LD+L Y+++++ N+VG G S E P+ + +++ H
Sbjct: 1576 LSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPT-AAPRNVVVH- 1633
Query: 1552 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRAN----------SSGEVFLTEL 1601
+T +L++ W P+ + + + + W+ R N + V L L
Sbjct: 1634 GATATQLDVT-WEPP--PLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNL 1690
Query: 1602 REATWYELRMRACNSAGCG 1620
T Y + + A N+AG G
Sbjct: 1691 TGYTAYMVSVAAFNAAGDG 1709
Score = 177 bits (449), Expect = 1e-43
Identities = 126/461 (27%), Positives = 207/461 (44%), Gaps = 41/461 (8%)
Query: 946 EPPDPPELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKN-KSDSWDFKQSTRNISPTI 1004
+PP P ++ +V+ARS+ L W DG S + + I+ + S W ++ +S
Sbjct: 1401 QPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSAS--VSHNA 1458
Query: 1005 NQANIVDLHPASVYSIRMYSFNKIGRSEPSKEL-TISTEEAAPDGPPMDVTLQPVTSQSI 1063
+ + L P + Y R+ + N IG SE S+E +++T +AAPD P +++ P T+ S+
Sbjct: 1459 SSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSV 1518
Query: 1064 QVTWKAPKKELQNGVIRGYQIGYRE--------------NSPGSN-----GQYSIVEMKA 1104
+ W+ P ++ NG++ G++I YRE N+PG+ YS+ +
Sbjct: 1519 LIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSR 1578
Query: 1105 TGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITS 1164
++ Y LDNL K +Y + + +N G GPSS E VP+ P NV T+
Sbjct: 1579 PSLTQ-YELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATA 1637
Query: 1165 DVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYS 1224
++W PP + NG ++GY++ FW ++ + V+L+ + +T Y
Sbjct: 1638 TQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYM 1697
Query: 1225 VQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKY 1284
V V A+ AGDG RS+ QT++ P P+ +K + +SV VSW P PNG++ Y
Sbjct: 1698 VSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGY 1757
Query: 1285 TIF---CSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVT 1341
+ CS + L+ ++ L G Y + A T VT
Sbjct: 1758 RLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVT 1817
Query: 1342 IEPAGKAPAK-----IISFGGTVTTPWMKDVRLPCNSVGDP 1377
P AP I+ + + W S GDP
Sbjct: 1818 TGPGEGAPGPPGVPIIVRYSSAIAIHW---------SSGDP 1849
Score = 133 bits (335), Expect = 2e-30
Identities = 148/631 (23%), Positives = 259/631 (41%), Gaps = 58/631 (9%)
Query: 939 LIQLTVQEPPDPPE-LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQST 997
+++ T+ + P PP + EV+ S+ L W N II + I ++ + + + +
Sbjct: 1292 ILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTAN-TATV 1350
Query: 998 RNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMD--VTL 1055
++P+ Q L P SVY R+ + + G E ++ L ++TE+ PP V
Sbjct: 1351 EVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQ 1410
Query: 1056 QPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDN 1115
+ V ++S+ ++W+ L +R Y I RE +G++++ + ++ + +D
Sbjct: 1411 EDVRARSVLLSWEPGSDGL--SPVRYYTIQTREL---PSGRWALHSASVSHNASSFIVDR 1465
Query: 1116 LKKFAQYGVVVQAFNRAGTGPSSSEINA-TTLEDVPSQPPENVRALSITSDVAVISWSEP 1174
LK F Y V+A N G S E + TTL+ P + P + T+ +I W P
Sbjct: 1466 LKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPP 1525
Query: 1175 PRSTLNGVLKGYRVIFWSLYVDG--------------EWGEMQNITTTRE-------RVE 1213
+NG+L G+R+ + L +G W E+ ++ + R + E
Sbjct: 1526 AEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYE 1585
Query: 1214 LRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP-GPPAGIKAVPSSASSVVVSWL 1272
L + K Y +++ Y G+G S + E VP P + ++A+ + V+W
Sbjct: 1586 LDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWE 1645
Query: 1273 PP--TKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTS 1330
PP NG I+ Y I+ G + ++ +L Y++ VAA +
Sbjct: 1646 PPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNA 1705
Query: 1331 AG---RGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDS 1387
AG R ++ T + A AP+ + F TT V + + P ++ +
Sbjct: 1706 AGDGPRSTPTQGQTQQAAPSAPSS-VKFSELTTT----SVNVSWEAPQFPNGILEGYRLV 1760
Query: 1388 EDSAIPVSMDGHRLIHT-----NGTLLLRAVK-AEDSGYYTCTATNTGGFDTIIVNLLVQ 1441
+ PV DG I T N L L+ AE Y T + I +
Sbjct: 1761 YEPCSPV--DGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTT 1818
Query: 1442 VP----PDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEW----KDVFI 1493
P P P + + +S+I + W GD G I +V++ + W KD+
Sbjct: 1819 GPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPK 1878
Query: 1494 SSSERSFKLDSLKCGTWYKVKLAAKNSVGSG 1524
S +F +D LK G Y ++ A N G G
Sbjct: 1879 EVSSYTFSMDILKPGVSYDFRVIAVNDYGFG 1909
Score = 122 bits (307), Expect = 3e-27
Identities = 135/523 (25%), Positives = 213/523 (40%), Gaps = 65/523 (12%)
Query: 876 RPIIIRWEKGDTVIDPDRVM----------RYAIATKDNGDEVVSTL--KLKPADRGDSV 923
R +++ WE G + P R R+A+ + S + +LKP S
Sbjct: 1416 RSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFT---SY 1472
Query: 924 FFSCHAINSYGE----DRGLIQLTVQEPPD--PPELEIREVKARSMNLRWTQRFDG--NS 975
F A N G+ + T+Q PD P L + S+ +RW + N
Sbjct: 1473 KFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKING 1532
Query: 976 IITGFDIEYK----------------NKSDSW---DFKQSTRNIS-PTINQANIVDLHPA 1015
I+ GF I Y+ N +W S RN+S P++ Q + +L+
Sbjct: 1533 ILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKH 1592
Query: 1016 SVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQ 1075
Y IRM +N +G S + EA P P +V + T+ + VTW+ P + Q
Sbjct: 1593 RRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQ 1652
Query: 1076 NGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG 1135
NG I+GY+I + E G+ + V+ ++ V L NL + Y V V AFN AG G
Sbjct: 1653 NGDIQGYKIYFWEAQRGNLTER--VKTLFLAENSV-KLKNLTGYTAYMVSVAAFNAAGDG 1709
Query: 1136 PSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLY- 1194
P S+ T + PS P +V+ +T+ +SW P NG+L+GYR+++
Sbjct: 1710 PRSTPTQGQTQQAAPSAP-SSVKFSELTTTSVNVSWEAPQFP--NGILEGYRLVYEPCSP 1766
Query: 1195 VDGEWGEMQNITTTRER------VELRGMEKFTNYSVQVLAYTQA-GDGVRSSVLYIQTK 1247
VDG + I T + ++++ + + Y ++ A T G + ++V
Sbjct: 1767 VDG----VSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVT-TGPG 1821
Query: 1248 EDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFC--SSPGSGQPAPSEYETSP 1305
E PGPP G+ + +S++ + W G I +Y I S G +
Sbjct: 1822 EGAPGPP-GVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEV 1880
Query: 1306 EQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKA 1348
+ + L G Y V AV G G S PA KA
Sbjct: 1881 SSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKA 1923
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 289 bits (740), Expect = 2e-77
Identities = 320/1338 (23%), Positives = 537/1338 (40%), Gaps = 159/1338 (11%)
Query: 389 GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA 448
G+ ++L+C GS +W R D++ S +I S QK +G Y+C
Sbjct: 119 GNRLVLTCLAEGSWPLEFKWMR-------DDSELTTYSSEYKYIIPSLQKLDAGFYRCVV 171
Query: 449 T--------RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVT 500
RK++ + ++ + VS ++N + P P VT
Sbjct: 172 RNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILN-------LLPITSYPRPQVT 224
Query: 501 WALDDEPIV---RDGSHRTNQYTMSDGTT-------ISHMNVTGPQIRDGGVYRCTARNL 550
W + I+ R NQ + TT + +N + + +
Sbjct: 225 WFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARD 284
Query: 551 VGSAEYQARINVRGPPSIRAMRNITAVAGR-DTLINCRVIGYPY--YSIKWYKDALLLPD 607
VG+ E A P + N + VAG +T + C P S+ W ++ + +
Sbjct: 285 VGTPETMA------PTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITS 338
Query: 608 N----HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL--SISQSVHVAVKVPPLI-- 659
R++ N T D G Y+C + + + + PP
Sbjct: 339 GLHSFGRRLTISNPT--------SADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTA 390
Query: 660 QPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS--LQIS 717
+P A + + + I C +P + W KD IS S + + ++S L+I
Sbjct: 391 EPESRISAEVEETVDIGCQAMGVPLPT-LQWYKDA---ISISRLQNPRYKVLASGGLRIQ 446
Query: 718 SVSLKHNGNYTCIASNAAATVSRERQL-IVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGY 776
+ + +G + C ASN + L + + P F +P + G +L C V G
Sbjct: 447 KLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGA 506
Query: 777 PPPKVMWK---HAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGV 833
P P + WK H SG+ + +P R +L + L I V +D G Y C A+N
Sbjct: 507 PKPAITWKRENHILASGSVR----IP---RFMLLESGGLQIAPVFIQDAGNYTCYAANTE 559
Query: 834 GTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIR--WEKGDTVIDP 891
G+ ++ S LTV I P + IKG L+C A + + +R W+K + + P
Sbjct: 560 GS-LNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTP 618
Query: 892 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP 951
R + E +L + GD +SC ++ G D + +L V E P P
Sbjct: 619 SSTSRIVV-------EKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSP 671
Query: 952 E---LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQAN 1008
+ + + ++ L W + FDGNS I + +E + W K N+ P +
Sbjct: 672 QNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPW--KVHLSNVGPEMTGVT 729
Query: 1009 IVDLHPASVYSIRMYSFNKIGRSEPSKELT-ISTEEAAPDGPPMDVTLQPVTSQSIQVTW 1067
+ L PA Y R+ + N++GR + S E + + E P PP ++ T+QSI V W
Sbjct: 730 VSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQW 789
Query: 1068 KAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTL-DNLKKFAQYGVVV 1126
+ P + NGV+RGY + YR G G+Y + T Y L +L + QY + V
Sbjct: 790 QPPPETEHNGVLRGYILRYR--LAGLPGEYQ--QRNITSPEVNYCLVTDLIIWTQYEIQV 845
Query: 1127 QAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGY 1186
A+N AG G S + TL+ VP+ PP+NV+ ++ S W+ PP+ +NG+ +GY
Sbjct: 846 AAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGY 905
Query: 1187 RVIFWSLYVDGEWGEMQNITTTR------ERVELRGMEKFTNYSVQVLAYTQAGDGVRSS 1240
+++ W + E + T + ++KFT Y VL +T GDG S+
Sbjct: 906 KLLAW----PADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPST 961
Query: 1241 VLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSE 1300
+ T+ED PG + +S+ VSW P + NG+I Y I G +
Sbjct: 962 PQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTH 1021
Query: 1301 YETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRG-----NSSEKVTIEPAGKAPAKIIS- 1354
S Y+I L+ Y + VAAVT+ G G S V + G +IS
Sbjct: 1022 TLNSTTH-EYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISN 1080
Query: 1355 --------------FGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHR 1400
G T + W+ + ++ ++GD V ++ + + +
Sbjct: 1081 ISPRSATLQFRPGYDGKTSISRWIVEGQV--GAIGDEEEWVTLYEEENEPDAQMLEIPNL 1138
Query: 1401 LIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPD--QPRLTVSKTSASS 1458
+T+ ++ V Y+ ++ V +Q PPD +TV S +S
Sbjct: 1139 TPYTHYRFRMKQVNIVGPSPYSPSSR---------VIQTLQAPPDVAPTSVTVRTASETS 1189
Query: 1459 ITLTWIP----GDNGGSSIRGFVLQY--SVDNSEEWKDVFISSSERSFKLDSLKCGTWYK 1512
+ L W+P NG G+ ++Y S S V ER F ++ L+ Y+
Sbjct: 1190 LRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYE 1249
Query: 1513 VKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARL---NLQGWNNGGCP 1569
+++ A N+VG+G SE++ +T PS + + ++ST L ++ + G
Sbjct: 1250 LQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLI 1309
Query: 1570 I------TAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCG-NE 1622
+ A L+ P+ +R N + L LR+ YEL++ A G G
Sbjct: 1310 LGYKILFRAKDLDPEPRS----HIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPS 1365
Query: 1623 TAQFATLDYDGSTIPPIK 1640
T D + PP++
Sbjct: 1366 TPLILERTKDDAPGPPVR 1383
Score = 239 bits (610), Expect = 2e-62
Identities = 365/1639 (22%), Positives = 625/1639 (38%), Gaps = 197/1639 (12%)
Query: 3 GAGEPRREEPP-PQPSAGLR-----SRESGAPSAGGWERAERGRGAAARPATGPPPRRIG 56
G G PR P +PS R SR AP G + A GR R A P RR
Sbjct: 24 GPGRPRGSPPGRARPSLAPRPGPEPSRPRAAPETSGGDTAGAGRCGGRRAAKLGPGRR-- 81
Query: 57 PLYGMWLVTFLLLLDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAA 116
G W + L L L +A +D + L Q+ + +V+ C A GS
Sbjct: 82 ---GWWALLALQL--HLLRALAQDDVAPYFKTEPGLPQIHLEGN-RLVLTCLAEGSWPLE 135
Query: 117 LRWY-------LATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAA 169
+W + + Y +P ++ + A Y C N
Sbjct: 136 FKWMRDDSELTTYSSEYKYIIPSLQKLDAGF--------------------YRCVVRNRM 175
Query: 170 GKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSII 229
G + V+ + + + + +G A+ L +S V+W ++ II
Sbjct: 176 GALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPR--PQVTWFREGHKII 233
Query: 230 PEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVT----DPAESI 285
P +R IT L I DA + Y K +GE + S LS+ P
Sbjct: 234 PSNRIAITLENQLVILATTTSDAGAYYVQAVNEK-NGENKTSPFIHLSIARDVGTPETMA 292
Query: 286 PTILDGFHSQEVWAGHT-VELPCTASGYPIP--AIRWLKDGRPLPADSRWTKRITGLTIS 342
PTI+ ++ V AG + L C AS P+ ++ W ++G + + R LTIS
Sbjct: 293 PTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGR--RLTIS 350
Query: 343 DLRTEDSGTYICEVT---NTFGSAEATGILMVIDPLHVTLTPK-KLKTGIGSTVILSCAL 398
+ + D+G Y+CE + F A AT L +I+P + T P+ ++ + TV + C
Sbjct: 351 NPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQA 410
Query: 399 TGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDF 458
G P T++WY++ + + + L++ L I + SG +QCFA+ + Q
Sbjct: 411 MGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTH 470
Query: 459 AIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQ 518
+ + + P + V G L C GAP P +TW ++ I+ GS R +
Sbjct: 471 TYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENH-ILASGSVRIPR 529
Query: 519 YTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI-RAMRNITAV 577
+ + + + + I+D G Y C A N GS A + V SI + +
Sbjct: 530 FMLLES---GGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVI 586
Query: 578 AGRDTLINCRVIGYPYYSIK--WYKD--ALLLPDNHRQVVFENGTLKLTDVQKGMDEGEY 633
G ++C P S++ W KD AL R VV ++G+L ++ G D G+Y
Sbjct: 587 KGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSG-DIGDY 645
Query: 634 LCSVLIQ------------------PQ--LSISQSVHVAVKVPPLIQPFEFPPASIGQLL 673
C ++ + PQ L S H V ++PF+ +L
Sbjct: 646 SCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFD----GNSPIL 701
Query: 674 YIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASN 733
Y +S + P ++ G + +GVT+ + Q ++ G A
Sbjct: 702 YYIVELSENNSPWKVHLSNVGPEM---TGVTVSGLTPARTYQFRVCAVNEVGRGQYSAET 758
Query: 734 AAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQ 793
+ + E PP+ +V + + V PPP+ + G
Sbjct: 759 SRLMLPEEPP---SAPPKNIVASGRTN--------QSIMVQWQPPPETE-HNGVLRGYIL 806
Query: 794 QYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYL-----CQASNGVGTDISKSMFLTVKIP 848
+Y L G Q +S + + L D+ + A NG G + +
Sbjct: 807 RYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQ 866
Query: 849 AMITSHP---------NTTIAIKGH---AKELNCTARGERPIIIRWEKGDTVIDPDRVMR 896
+ T+ P +TTI + + +N +G + ++ W P+ V
Sbjct: 867 GVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYK--LLAWPAD----APEAVTV 920
Query: 897 YAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP----E 952
IA +G LK + + F S + G+ V D P
Sbjct: 921 VTIAPDFHGVHHGHITNLK---KFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGH 977
Query: 953 LEIREVKARSMNLRWTQRFDGNSIITGFDIEYK--NKSDSWDFKQSTRNISPTINQANIV 1010
L E+ S+ + W + + N IITG+ I ++ ++DS + T ++ T ++ I
Sbjct: 978 LSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDS----RLTHTLNSTTHEYKIQ 1033
Query: 1011 DLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKA- 1069
L + Y+I + + +G + S G P ++ + ++ +S + ++
Sbjct: 1034 GLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPG 1093
Query: 1070 --PKKELQNGVIRGYQIGYRENSPGSNGQY-SIVEMKATGDSEVYTLDNLKKFAQYGVVV 1126
K + ++ G Q+G + G ++ ++ E + D+++ + NL + Y +
Sbjct: 1094 YDGKTSISRWIVEG-QVG----AIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRM 1148
Query: 1127 QAFNRAGTGP-SSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLK- 1184
+ N G P S S TL+ P P +V + + + W P S NG +
Sbjct: 1149 KQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPES 1208
Query: 1185 -GYRVIFWSLYVDGEWGEMQNITTTRER-VELRGMEKFTNYSVQVLAYTQAGDGVRSSVL 1242
GYR+ +W + Q ++ ER + +E++ Y +Q+ A+ G G S V+
Sbjct: 1209 VGYRIKYWRSDLQSS-AVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVV 1267
Query: 1243 YIQTKEDVP-GPPAGIKAVPSSASSVVVSW--LPPTKPNGVIRKYTIFCSSPGSGQPAPS 1299
+T+E VP P + A S++ ++++W +P NG+I Y I + S
Sbjct: 1268 RGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRS 1327
Query: 1300 EYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIE-PAGKAPAKIISFGGT 1358
+A L + Y L V A T G G S + +E AP
Sbjct: 1328 HIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPG-------- 1379
Query: 1359 VTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMD-GHRLI----HTNGTLLLRAV 1413
VRL V + + W E + I + +RL HT T+ + A
Sbjct: 1380 ------PPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGAT 1433
Query: 1414 --------KAEDSGY-YTCTATNTGGFDTIIVNLLV-------QVPPDQPRLTVSKTSAS 1457
A +S Y + +A G+ + ++ PP + + ++ +A
Sbjct: 1434 VRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTAR 1493
Query: 1458 SITLTWIPGDNGGSSIRGFVLQYSVDNSEEWK--DVFISSSERSFKLDSLKCGTWYKVKL 1515
S+ L W+PG +G S IR F +Q EW+ IS + +D L+ T YK++L
Sbjct: 1494 SLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRL 1553
Query: 1516 AAKNSVGSGRISEIIEAKT 1534
A N +G S EA T
Sbjct: 1554 KATNDIGDSDFSSETEAVT 1572
Score = 169 bits (428), Expect = 3e-41
Identities = 119/432 (27%), Positives = 201/432 (46%), Gaps = 30/432 (6%)
Query: 945 QEPPDPPELEI--REVKARSMNLRWTQRFDGNSIITGFDIEYKN-KSDSWDFKQSTRNIS 1001
+ P P EL + EV ARS+ L+W DG S I F ++ + W S+ +
Sbjct: 1475 ERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHE 1534
Query: 1002 PTINQANIVD-LHPASVYSIRMYSFNKIGRSEPSKEL-TISTEEAAPDGPPMDVTLQPVT 1059
T A +VD L P + Y +R+ + N IG S+ S E ++T + P PP V+ P T
Sbjct: 1535 AT---ACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHT 1591
Query: 1060 SQSIQVTWKAPKKELQNGVIRGYQIGYRE--NSPGSN-----------------GQYSIV 1100
+ S+ + W+ P+ E NG+++GY+I YRE GS Q S
Sbjct: 1592 TSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFK 1651
Query: 1101 EMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRAL 1160
+ ++ S + L +LKK+ +Y V++ A+N G P+S+ + E P+ P+NV+
Sbjct: 1652 TVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVT 1711
Query: 1161 SITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKF 1220
+T+ ++W PP + NG ++GY++ +W E +M+ + V L+ +
Sbjct: 1712 PLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSH 1771
Query: 1221 TNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV 1280
T Y V + A+ AGDG +S +T + PG P+ + +++++ VSW P NG+
Sbjct: 1772 TKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGI 1831
Query: 1281 IRKYTIFCS--SPGSGQPAPSEYETSPE-QLFYRIAHLNRGQQYLLWVAAVTSAGRGNSS 1337
++ Y + +P G E Q + ++ L +G Y V A T
Sbjct: 1832 LQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQ 1891
Query: 1338 EKVTIEPAGKAP 1349
+T PA +P
Sbjct: 1892 ANITAGPAEGSP 1903
Score = 168 bits (426), Expect = 5e-41
Identities = 167/644 (25%), Positives = 275/644 (42%), Gaps = 77/644 (11%)
Query: 939 LIQLTVQEPPDPP-ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQST 997
+++ T + P PP L EV+ S+ + W + N II G+ I Y+ S S +T
Sbjct: 1369 ILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSS-PHTFTT 1427
Query: 998 RNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMD--VTL 1055
+ T+ Q DL P S Y R+ + + G EP + I+TE+ PP + V
Sbjct: 1428 VEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQ 1487
Query: 1056 QPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDN 1115
VT++S+++ W P + IR + + RE G++ + ++ +D
Sbjct: 1488 AEVTARSLRLQW-VPGSD-GASPIRYFTMQVREL---PRGEWQTYSSSISHEATACVVDR 1542
Query: 1116 LKKFAQYGVVVQAFNRAGTGPSSSEINA-TTLEDVPSQPPENVRALSITSDVAVISWSEP 1174
L+ F Y + ++A N G SSE A TTL+DVP +PP +V A T+ +I W P
Sbjct: 1543 LRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPP 1602
Query: 1175 PRSTLNGVLKGYRVIFWSL-YVDGEWGEMQ---------------------NITTTRERV 1212
+LNG+L+GYR+ + L Y G E + N ++T
Sbjct: 1603 RDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMC 1662
Query: 1213 ELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPG-PPAGIKAVPSSASSVVVSW 1271
EL ++K+ Y V + AY G+ S+ + + E P P ++ P +AS + V+W
Sbjct: 1663 ELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTW 1722
Query: 1272 --LPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFY------RIAHLNRGQQYLL 1323
PP NG I+ Y I+ A S+ ET ++ + R+ +L +YL+
Sbjct: 1723 DPPPPESQNGNIQGYKIYY------WEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLV 1776
Query: 1324 WVAAVTSAGRGNSSEKV---TIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVG----- 1375
++A +AG G S+ T + A AP+ ++F +T P + G
Sbjct: 1777 SISAFNAAGDGPKSDPQQGRTHQAAPGAPS-FLAFSEITSTTLNVSWGEPAAANGILQGY 1835
Query: 1376 ----DPAPAVKWTKDSEDSAIPVSMDGHRLIH----TNGTLLLRAVKAEDSGYYTCTATN 1427
+P V+ S+ + V + R + T G V+A T T
Sbjct: 1836 RVVYEPLAPVQGV--SKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQAR-------TITY 1886
Query: 1428 TGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEE 1487
I + P PR + SAS +TL W G +G + G+V++ +
Sbjct: 1887 GPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGL 1946
Query: 1488 W----KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRIS 1527
W KD+ S++ + LD L+ G Y+ ++ A N G G S
Sbjct: 1947 WDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPS 1990
Score = 121 bits (304), Expect = 6e-27
Identities = 169/756 (22%), Positives = 299/756 (39%), Gaps = 114/756 (15%)
Query: 933 YGEDRGLIQLTVQEPPD--PPELEIREVKARSMNLRWT----QRFDGNSIITGFDIEYKN 986
Y +IQ T+Q PPD P + +R S+ LRW +++GN G+ I+Y
Sbjct: 1159 YSPSSRVIQ-TLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKY-- 1215
Query: 987 KSDSWDFKQSTRNISPTIN-----QANIVDLHPASVYSIRMYSFNKIGRSEPSKELTIST 1041
W + ++ ++ + I +L Y ++M +FN +G S+ + T
Sbjct: 1216 ----WRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRT 1271
Query: 1042 EEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVE 1101
E+ P P +V+ + V+S I +TW + ++ QNG+I GY+I +R + IV
Sbjct: 1272 RESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVR 1331
Query: 1102 MKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINATTLEDVPSQPPENVRAL 1160
T + L L+KF Y + V AF R G G PS+ I T +D P P V
Sbjct: 1332 GNHTQSA---LLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPE 1388
Query: 1161 SITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKF 1220
+ V ++ W P NG++ GY++ + + T + +
Sbjct: 1389 VRLTSVRIV-WQPPEEP--NGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPE 1445
Query: 1221 TNYSVQVLAYTQAGDGVRSSVLYIQT-KEDVPGPPAGIKAVPSS---ASSVVVSWLPPTK 1276
+ Y ++ A T+ G G I T K + P PP + VP + A S+ + W+P +
Sbjct: 1446 SAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPREL-LVPQAEVTARSLRLQWVPGSD 1504
Query: 1277 PNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGN- 1335
IR +T+ G+ S E + L Y L + A G +
Sbjct: 1505 GASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDF 1564
Query: 1336 SSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVS 1395
SSE + P + G TP L ++W + D ++
Sbjct: 1565 SSETEAVTTLQDVPGE--PPGSVSATPHTTSSVL-----------IQW-QPPRDESLNGL 1610
Query: 1396 MDGHRLIHT-------NGT--------LLLRAVKAEDSGYYTCTATNTGG---------- 1430
+ G+R+ + +GT + L A S + T +++T
Sbjct: 1611 LQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKY 1670
Query: 1431 --FDTIIV--NLLVQVPPDQP---------------RLTVSKTSASSITLTWIPG--DNG 1469
++ I+ N++ + P P + V+ +AS + +TW P ++
Sbjct: 1671 RRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQ 1730
Query: 1470 GSSIRGFVLQY----SVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGR 1525
+I+G+ + Y S + +E+ K +F+ E +L +L T Y V ++A N+ G G
Sbjct: 1731 NGNIQGYKIYYWEADSQNETEKMKVLFLP--EPVVRLKNLTSHTKYLVSISAFNAAGDGP 1788
Query: 1526 ISEIIEAKTHGREPSFSKDQHLFTHINSTHARLN----------LQGWNNGGCPITAI-- 1573
S+ + +TH P + F+ I ST ++ LQG+ P+ +
Sbjct: 1789 KSDPQQGRTHQAAPG-APSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQG 1847
Query: 1574 ---VLEYRPKGTW-AWQGLRANSSGEVFLTELREAT 1605
V+ +G W W +R + G + ++ T
Sbjct: 1848 VSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQART 1883
Score = 115 bits (289), Expect = 3e-25
Identities = 167/731 (22%), Positives = 287/731 (39%), Gaps = 83/731 (11%)
Query: 950 PPELEIREVKARSMNLRWTQ--RFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQA 1007
P + V + + L WT D N +I G+ I ++ K + + + T A
Sbjct: 1280 PENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHT-QSA 1338
Query: 1008 NIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTW 1067
+ L +Y +++ +F +IG PS L + + GPP+ + V S+++ W
Sbjct: 1339 LLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVW 1398
Query: 1068 KAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQ 1127
+ P++ NG+I GYQI YR S S ++ VE+ AT +T +L + Y +
Sbjct: 1399 QPPEEP--NGIILGYQIAYRLAS-SSPHTFTTVEVGAT--VRQFTATDLAPESAYIFRLS 1453
Query: 1128 AFNRAGTG-PSSSEINATTLEDVPSQPPEN-VRALSITSDVAVISWSEPPRSTLNGVLKG 1185
A R G G P + + T + P+ P E V +T+ + W P S ++
Sbjct: 1454 AKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWV--PGSDGASPIRY 1511
Query: 1186 YRVIFWSLYVDGEWGEMQN-ITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLY- 1243
+ + L GEW + I+ + + FT+Y +++ A GD SS
Sbjct: 1512 FTMQVREL-PRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEA 1570
Query: 1244 IQTKEDVPG-PPAGIKAVPSSASSVVVSWLPPTKP--NGVIRKYTIFCSS----PGSGQP 1296
+ T +DVPG PP + A P + SSV++ W PP NG+++ Y I+ GSG
Sbjct: 1571 VTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTE 1630
Query: 1297 AP---------------SEYET---SPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE 1338
A S ++T S + HL + ++Y + + A G +S
Sbjct: 1631 AKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASA 1690
Query: 1339 KVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVK------------WTKD 1386
V + APA ++ TP DP P W D
Sbjct: 1691 PVEVFVGEAAPA--MAPQNVQVTPLTAS---QLEVTWDPPPPESQNGNIQGYKIYYWEAD 1745
Query: 1387 SEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTII---VNLLVQVP 1443
S++ + + L + L+ + + + +A N G Q
Sbjct: 1746 SQNETEKMKV----LFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAA 1801
Query: 1444 PDQPR-LTVSKTSASSITLTWIPGDNGGSSIRGFVLQYS----VDNSEEWKDVFISSS-E 1497
P P L S+ +++++ ++W ++G+ + Y V + V + + +
Sbjct: 1802 PGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQ 1861
Query: 1498 RSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHAR 1557
R K+ L G Y ++ A+ + I A P +D + + +
Sbjct: 1862 RWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRD----VLVTKSASE 1917
Query: 1558 LNLQGW---NNGGCPITAIVLEYRPKGTWAWQGL-----RANSSGEVFLTELREATWYEL 1609
L LQ W ++G P T V+E RP W R+ +S + L +LR+ YE
Sbjct: 1918 LTLQ-WTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEF 1976
Query: 1610 RMRACNSAGCG 1620
R+ A N AG G
Sbjct: 1977 RVVAVNEAGYG 1987
Score = 70.1 bits (170), Expect = 2e-11
Identities = 71/293 (24%), Positives = 130/293 (44%), Gaps = 22/293 (7%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNT 1428
L C + DP ++++ ++ A+ S ++ +G+LL+ + D G Y+C +
Sbjct: 593 LHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSE 652
Query: 1429 GGFDTIIVNL-LVQVPPDQPRLTVSKTSASS--ITLTWIPGDNGGSSIRGFVLQYSVDNS 1485
GG D+ + L ++++P L VS S+ S + L+W+ +G S I ++++ S +N+
Sbjct: 653 GGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELS-ENN 711
Query: 1486 EEWKDVFISS---SERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFS 1542
WK V +S+ + L Y+ ++ A N VG G+ S EP +
Sbjct: 712 SPWK-VHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSA 770
Query: 1543 KDQHLFTHINSTHARLNLQGW-------NNGGCPITAIVLEYRPKGTWAWQGLRANSSGE 1595
+++ T+ + +Q W +NG + +L YR G R +S E
Sbjct: 771 PPKNIVAS-GRTNQSIMVQ-WQPPPETEHNG--VLRGYILRYRLAGLPGEYQQRNITSPE 826
Query: 1596 V---FLTELREATWYELRMRACNSAGCGNETAQFATLDYDGSTIPPIKSAQGE 1645
V +T+L T YE+++ A N AG G + G P ++ Q E
Sbjct: 827 VNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTE 879
Score = 42.0 bits (97), Expect = 0.006
Identities = 35/140 (25%), Positives = 59/140 (42%), Gaps = 5/140 (3%)
Query: 912 LKLKPADRGDSVFFSCHAIN-SYGED--RGLIQLTVQEPPDPPELEIREVKARSMNLRWT 968
LK++ +G + FF A +YG + + + P P + A + L+WT
Sbjct: 1864 LKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWT 1923
Query: 969 QRFDGNSIITGFDIEYKNKSDS-WDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNK 1027
+ G++ TG+ IE + + WD S T ++ L Y R+ + N+
Sbjct: 1924 EGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNE 1983
Query: 1028 IGRSEPSKELT-ISTEEAAP 1046
G EPS T +S + AP
Sbjct: 1984 AGYGEPSNPSTAVSAQVEAP 2003
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 278 bits (710), Expect = 5e-74
Identities = 278/1069 (26%), Positives = 452/1069 (42%), Gaps = 128/1069 (11%)
Query: 550 LVGSAEYQARINVRG--PPSIRAMRNIT------AVAGRDTLINCRVI---GYPYYSIKW 598
L G++ + A + V G + A+R ++ + G + L++C G P IKW
Sbjct: 17 LFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPV--IKW 74
Query: 599 YKDA--LLLPDNHRQVVFENGTLKLTDVQKGM----DEGEYLCSVLIQPQLSI-SQSVHV 651
KD L L + R+ NG+L + ++ DEG Y C + SI S++ V
Sbjct: 75 KKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKV 134
Query: 652 AVKVP-PLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEF 710
AV P + E A +G + + C V MP I W+K+ Q + G +
Sbjct: 135 AVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPT-IHWQKNQQDLTPIPGDSRVVVLP 193
Query: 711 MSSLQISSVSLKHNGNYTCIASNAAAT-VSRERQLIVRVPPR------FVVQPNNQDGIY 763
+LQIS + G Y C A N A++ E ++ + P F+ +P+N I
Sbjct: 194 SGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIE 253
Query: 764 GKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGR-IQILPNSSLLIRHVLEEDI 822
GK VL C V GYPPP W + + L + +L S+LLI +V ++D
Sbjct: 254 GKDAVLECCVSGYPPPSFTWLRGE--------EVIQLRSKKYSLLGGSNLLISNVTDDDS 305
Query: 823 GYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRW 882
G Y C + +IS S LTV +P +HP+ A + E CT G+ + W
Sbjct: 306 GMYTCVVTYK-NENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNW 364
Query: 883 EKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQL 942
K V+ P + S L++ + D F+ C A N G + QL
Sbjct: 365 MKNGDVVIPSDYFQIVGG---------SNLRILGVVKSDEGFYQCVAENEAGNAQTSAQL 415
Query: 943 TVQEPPDPPELEIRE---------VKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDF 993
V +P P + V +R + L W + I F + + + D+ +
Sbjct: 416 IVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRE- 474
Query: 994 KQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTE-EAAPDGPPMD 1052
++ P Q + +L P ++Y+ R+ ++N+ G E S+ + ++T+ E GP +
Sbjct: 475 -RALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVEN 533
Query: 1053 VTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYT 1112
+ + SI +TW+ P NG ++GY++ E S G + D Y
Sbjct: 534 LQAVSTSPTSILITWEPPA--YANGPVQGYRLFCTEVSTGKEQNIEV-------DGLSYK 584
Query: 1113 LDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWS 1172
L+ LKKF +Y + A+NR G G S+ +I TL DVPS PP+NV + S +SW
Sbjct: 585 LEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWL 644
Query: 1173 EPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQ 1232
PP T NG + GY++ GEM+ + G+EK + YS QV A T
Sbjct: 645 PPPSGTQNGFITGYKIRHRK---TTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTV 701
Query: 1233 AGDGVRSSVLYIQTKED------VPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTI 1286
G G S+ +T E+ VP P+ + P + + +++SW PP PN V+R Y I
Sbjct: 702 NGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYII 760
Query: 1287 FCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRG------NSSEKV 1340
G G P +Q +Y I L Y++ + A +AG G ++ +
Sbjct: 761 ---GYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSI 817
Query: 1341 T--IEPAGKAPAKIISFGGTV---TTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVS 1395
T +P P + F +V +TP + V + ++ A V W D+++P +
Sbjct: 818 TDPTDPVDYYPL-LDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWA----DNSVPKN 872
Query: 1396 MDGH--RLIHTNGTLLLRA---VKAEDSGYYTCTAT----NTGGFDTIIV---------- 1436
RL A K+ED+ + TAT NT +++V
Sbjct: 873 QKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWS 932
Query: 1437 -----NLLVQVPPDQPR-LTV--SKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNS--- 1485
P P+ LTV + ++ ++W P I ++L Y++D +
Sbjct: 933 MTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPI 992
Query: 1486 EEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKT 1534
++W IS + ++ L T Y ++ A+NS G G +S+ I +T
Sbjct: 993 DDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRT 1041
Score = 129 bits (323), Expect = 4e-29
Identities = 229/1033 (22%), Positives = 390/1033 (37%), Gaps = 131/1033 (12%)
Query: 300 GHTVELPCTA-SGYPIPAIRWLKDG--RPLPADSRWTKRITG-LTISDL-----RTEDSG 350
G V L C+A S +P I+W KDG L D R + G L I ++ D G
Sbjct: 54 GGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEG 113
Query: 351 TYICEVT--NTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRW 408
Y CE + ++ T + V PL + + +G TV+L C + G P TI W
Sbjct: 114 LYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHW 173
Query: 409 YRNTELVLPDEAIS-IRGLSNETLLITSAQKSHSGAYQCFATRKA--QTAQDFAIIALED 465
+N + + P S + L + L I+ Q G Y+C A A +T + + L D
Sbjct: 174 QKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSD 233
Query: 466 -GTPR---IVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTM 521
G R + S V G+ L C G PPP+ TW +E I R+ +Y++
Sbjct: 234 PGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVI----QLRSKKYSL 289
Query: 522 SDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPP-SIRAMRNITAVAGR 580
G+ + NVT D G+Y C + A + V PP + N+ A
Sbjct: 290 LGGSNLLISNVTDD---DSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESM 346
Query: 581 DTLINCRVIGYPYYSIKWYKDA-LLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLI 639
D C V G P ++ W K+ +++P ++ Q+V L++ V K DEG Y C +
Sbjct: 347 DIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV-GGSNLRILGVVKS-DEGFYQC--VA 402
Query: 640 QPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQ---- 695
+ + +Q+ + P I P++ + +P +VSS +R++WR +
Sbjct: 403 ENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDV--VPVLVSS--RFVRLSWRPPAEAKGN 458
Query: 696 -----VIISGSGVTIE---SKEFMSSLQISSVSLKHNGNYT--CIASNAAATVSRERQLI 745
V S G E + SLQ++ +LK YT +A N + +
Sbjct: 459 IQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIK 518
Query: 746 VRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYH---PVPLTG 802
V P V P + + + + + PP A +G Q Y TG
Sbjct: 519 VATQPELQV-PGPVENLQAVSTSPTSILITWEPP------AYANGPVQGYRLFCTEVSTG 571
Query: 803 RIQILPNSSLLIR-HVLEEDIGYYL-CQASNGVGTDISKSMFLTVKIPAMITSHPNTTIA 860
+ Q + L + L++ Y L A N G +S V + + ++ P
Sbjct: 572 KEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPP----- 626
Query: 861 IKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAI----ATKDNGDEVVSTLKL-- 914
+ ++ R I + W + + Y I T+ E + L
Sbjct: 627 -----QNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWY 681
Query: 915 --KPADRGDSVFFSCHAINSYGEDRGLIQLTVQEP---------PDPPELEIREVKARSM 963
++G F A+ G T + P PD P + +
Sbjct: 682 LFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCI 741
Query: 964 NLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMY 1023
+ WT + N ++ G+ I Y S T + +I L +S Y I +
Sbjct: 742 IMSWTPPLNPNIVVRGYIIGYGVGSP----YAETVRVDSKQRYYSIERLESSSHYVISLK 797
Query: 1024 SFNKIGRSEP------SKELTISTEE-----------------AAPDGPPMDVTLQPVTS 1060
+FN G P ++ +T T+ + P PP+ V +T
Sbjct: 798 AFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTH 857
Query: 1061 QSIQVTW--KAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKK 1118
+++V+W + K + +R Y + +R S ++ +Y + + YT LK
Sbjct: 858 DAVRVSWADNSVPKNQKTSEVRLYTVRWR-TSFSASAKYKSEDTTSLS----YTATGLKP 912
Query: 1119 FAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSD--VAVISWSEPPR 1176
Y V + S +ATT E P+ P+++ ++ ++SW P
Sbjct: 913 NTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLE 972
Query: 1177 STLNGVLKGYRVIFWSLYVD---GEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQA 1233
+ NG + Y ++F++L + +W M+ I+ R ++ + T Y ++ A
Sbjct: 973 A--NGKITAY-ILFYTLDKNIPIDDW-IMETISGDRLTHQIMDLNLDTMYYFRIQARNSK 1028
Query: 1234 GDGVRSSVLYIQT 1246
G G S + +T
Sbjct: 1029 GVGPLSDPILFRT 1041
Score = 103 bits (257), Expect = 2e-21
Identities = 111/427 (25%), Positives = 174/427 (40%), Gaps = 57/427 (13%)
Query: 64 VTFLLLLDSLHKARPEDVG------TSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSA-A 116
+ F+L SL A + G T+L F+++ VT V++ C A
Sbjct: 13 LAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGG-NVLLDCSAESDRGVPV 71
Query: 117 LRW-----YLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDND---YFCTAE-N 167
++W +LA G D + +NG+L + + +S H D Y C A
Sbjct: 72 IKWKKDGIHLALGMD-----ERKQQLSNGSLLIQ----NILHSRHHKPDEGLYQCEASLG 122
Query: 168 AAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVS 227
+G I S +V + + E + G+ + KC + + E + + W+K+
Sbjct: 123 DSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEV---IGEPMPTIHWQKNQQD 179
Query: 228 IIP---EHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAES 284
+ P + R + G L IS +Q D + YRC ++ S T R+ ++DP
Sbjct: 180 LTPIPGDSRVVVLPSGALQISRLQPGD-IGIYRCSARNPASSRTGNEAEVRI-LSDP--- 234
Query: 285 IPTILDGFHSQEVWA----------GHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTK 334
G H Q + G L C SGYP P+ WL+ + S+
Sbjct: 235 ------GLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYS 288
Query: 335 RITG--LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTV 392
+ G L IS++ +DSG Y C VT + A+ L V+ P P L +
Sbjct: 289 LLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDI 348
Query: 393 ILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKA 452
C ++G P T+ W +N ++V+P + I G SN L I KS G YQC A +A
Sbjct: 349 EFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSN--LRILGVVKSDEGFYQCVAENEA 406
Query: 453 QTAQDFA 459
AQ A
Sbjct: 407 GNAQTSA 413
Score = 43.1 bits (100), Expect = 0.003
Identities = 51/207 (24%), Positives = 86/207 (41%), Gaps = 14/207 (6%)
Query: 1440 VQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERS 1499
+QVP L TS +SI +TW P ++G+ L + ++ + +++ + S
Sbjct: 525 LQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDG--LS 582
Query: 1500 FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLN 1559
+KL+ LK T Y ++ A N G G ++ I T PS +NS +++
Sbjct: 583 YKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVS 642
Query: 1560 L----QGWNNGGCPITAIVLEYR-PKGTWAWQGLRANSSGEVFLTELREATWYELRMRAC 1614
G NG IT + +R + L N+ +F T L + + Y ++ A
Sbjct: 643 WLPPPSGTQNGF--ITGYKIRHRKTTRRGEMETLEPNNLWYLF-TGLEKGSQYSFQVSAM 699
Query: 1615 NSAGCGNE----TAQFATLDYDGSTIP 1637
G G TA+ D D S +P
Sbjct: 700 TVNGTGPPSNWYTAETPENDLDESQVP 726
Score = 37.4 bits (85), Expect = 0.16
Identities = 37/140 (26%), Positives = 60/140 (42%), Gaps = 10/140 (7%)
Query: 1012 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTL--QPVTSQSIQVTWKA 1069
L P ++Y + S S +T EAAP P D+T+ + +++ V+W+
Sbjct: 910 LKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQP 969
Query: 1070 PKKELQNGVIRGYQIGYR--ENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQ 1127
P + NG I Y + Y +N P + + +GD + + +L Y +Q
Sbjct: 970 PLEA--NGKITAYILFYTLDKNIPIDDWIMETI----SGDRLTHQIMDLNLDTMYYFRIQ 1023
Query: 1128 AFNRAGTGPSSSEINATTLE 1147
A N G GP S I TL+
Sbjct: 1024 ARNSKGVGPLSDPILFRTLK 1043
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 244 bits (623), Expect = 6e-64
Identities = 258/1029 (25%), Positives = 421/1029 (40%), Gaps = 111/1029 (10%)
Query: 576 AVAGRDTLINCRVIGYPYYSIKWYKDAL---LLPDNHRQVVFENGTLKLTDVQKGM---- 628
+V G ++NC P I+W KD L+ D+ RQ++ +G+L +++V
Sbjct: 64 SVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLL-PDGSLFISNVVHSKHNKP 122
Query: 629 DEGEYLCSVLIQPQLSI-SQSVHVAVKVPPLI--QPFEFPPASI--GQLLYIPCVVSSGD 683
DEG Y C ++ +I S++ + V P QP P+S+ G + C V++
Sbjct: 123 DEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQP---EPSSVYAGNNAILNCEVNADL 179
Query: 684 MPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIA-SNAAATVSRER 742
+P + W ++ Q ++ V K L IS+ + G Y C+ S S E
Sbjct: 180 VPF-VRWEQNRQPLLLDDRVI---KLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEV 235
Query: 743 QLIVRVPPR------FVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYH 796
+L V P F+ QP+ + G+ VL C G P P + W + + + +
Sbjct: 236 ELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTES-- 293
Query: 797 PVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPN 856
+ R+ +L SL I V E+D G Y C A NG T I LTV+ P
Sbjct: 294 ----SERLVLLAGGSLEISDVTEDDAGTYFCIADNGNET-IEAQAELTVQAQPEFLKQPT 348
Query: 857 TTIAIKGHAKELNCTARGERPIIIRWEK-GDTVIDPDRVMRYAIATKDNGDEVVSTLKLK 915
A + C G+ ++W K GD VI D Y K++ +V+ +K
Sbjct: 349 NIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSD----YFKIVKEHNLQVLGLVK-- 402
Query: 916 PADRGDSVFFSCHAINSYGEDRGLIQLTVQE---------PPDPPELEIREVKARSMNLR 966
D F+ C A N G + QL + E P P ++ V R + L
Sbjct: 403 ----SDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLT 458
Query: 967 W-TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSF 1025
W T D + + + Y + + + ++T + P Q I +L PA+VY R+ +
Sbjct: 459 WRTPASDPHGDNLTYSVFYTKEGIARERVENTSH--PGEMQVTIQNLMPATVYIFRVMAQ 516
Query: 1026 NKIGRSEPSKELTISTE-EAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQI 1084
NK G E S L + T+ E GP ++ + SI VTW+ P NG I+ Y++
Sbjct: 517 NKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSG--NGEIQNYKL 574
Query: 1085 GYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINAT 1144
Y E + S YT++ LKK+ +Y V A+N+ G G S+ ++
Sbjct: 575 YYMEKGTDKEQDVDV-------SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVR 627
Query: 1145 TLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQN 1204
TL DVPS P+N+ S +I W P +T NG + GY++ + + E
Sbjct: 628 TLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETL- 686
Query: 1205 ITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKED------VPGPPAGIK 1258
++ T+ + G+++ T Y+ +V A T G G + L +T E VP P+ +
Sbjct: 687 VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLH 746
Query: 1259 AVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRG 1318
P +S+VVSW PP N V+R Y I G G P + +Q +Y I +L+
Sbjct: 747 VRP-LVTSIVVSWTPPENQNIVVRGYAI---GYGIGSPHAQTIKVDYKQRYYTIENLDPS 802
Query: 1319 QQYLLWVAAVTSAGRGNS--SEKVTIEPAGKAPAKIISFGGTVT-----TPWMKDVRLPC 1371
Y++ + A + G G VT + + T TP M V +
Sbjct: 803 SHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQA 862
Query: 1372 NSVGDPAPAVKWTKDS-------EDSA---------IPVSMDGHRLIHTNGTLLLRAVKA 1415
+ + + W +S DS IP + T + L+ +K
Sbjct: 863 SILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKP 922
Query: 1416 EDSGYYTCTATNTGGFDT-------IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDN 1468
++ T T L+ PP + + +I + W P
Sbjct: 923 NTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSE 982
Query: 1469 GGSSIRGFVLQYSVD-NSE--EWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGR 1525
I G+++ YS D N+E +W + + + ++ L T Y K+ A+NS G G
Sbjct: 983 ANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGP 1042
Query: 1526 ISEIIEAKT 1534
+SE ++ +T
Sbjct: 1043 MSEAVQFRT 1051
Score = 145 bits (366), Expect = 4e-34
Identities = 245/1067 (22%), Positives = 409/1067 (38%), Gaps = 136/1067 (12%)
Query: 265 SGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGR 324
SG QS GA + P + +D + G +V L C+A P P I W KDG
Sbjct: 36 SGSAPQSPGASIRTFTPFYFLVEPVDTLSVR----GSSVILNCSAYSEPSPKIEWKKDGT 91
Query: 325 --PLPADSR------WTKRITGLTISDLRTEDSGTYICEVT-NTFGSA-EATGILMVIDP 374
L +D R + I+ + S D G Y C T + G+ T L+V
Sbjct: 92 FLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL 151
Query: 375 LHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLIT 434
T P+ G+ IL+C + +RW +N + +L D+ + L + L+I+
Sbjct: 152 PRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVI--KLPSGMLVIS 209
Query: 435 SAQKSHSGAYQCFATRKA--QTAQDFAIIALEDGTPRIVSSF------SEKVVNPGEQFS 486
+A + G Y+C + + + + L D P ++S S V G+
Sbjct: 210 NATEGDGGLYRCVVESGGPPKYSDEVELKVLPD--PEVISDLVFLKQPSPLVRVIGQDVV 267
Query: 487 LMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCT 546
L C A G P PT+ W ++E + + S R + G ++ +VT D G Y C
Sbjct: 268 LPCVASGLPTPTIKWMKNEEALDTESSER---LVLLAGGSLEISDVTED---DAGTYFCI 321
Query: 547 ARNLVGSAEYQARINVRGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA-LL 604
A N + E QA + V+ P ++ NI A D + C V G P ++KW K+ ++
Sbjct: 322 ADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMV 381
Query: 605 LPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEF 664
+P ++ ++V E+ L V+ DEG Y C I+++ + + E
Sbjct: 382 IPSDYFKIVKEHNLQVLGLVKS--DEGFYQC---------IAENDVGNAQAGAQLIILEH 430
Query: 665 PPASIGQLLYIP-CVVSS--GDMPIRITWRKDGQVIISGSGVTIE---SKEFMSSLQISS 718
PA+ G L P VV+S I++TWR G +T +KE ++ ++ +
Sbjct: 431 APATTGPLPSAPRDVVASLVSTRFIKLTWRTPAS-DPHGDNLTYSVFYTKEGIARERVEN 489
Query: 719 VSLKHNGNYTCIASN-AAATVSRERQLIVR--------VPPRFVVQPNNQDGIYGKAGVL 769
S H G N ATV R + P R QP Q + G A L
Sbjct: 490 TS--HPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQ--LPGPAPNL 545
Query: 770 NCSVDGYPPPKVMWK-HAKGSGNPQQYHPVPL---TGRIQILPNS--SLLIRHVLEEDIG 823
V W+ G+G Q Y + T + Q + S S I + +
Sbjct: 546 RAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEY 605
Query: 824 YYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWE 883
+ A N G +S + + ++ P + L+ R + I+I W+
Sbjct: 606 SFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAP----------QNLSLEVRNSKSIMIHWQ 655
Query: 884 KGDTVIDPDRVMRYAIATK--DNGDEVVSTL--------KLKPADRGDSVFFSCHAINSY 933
++ Y I + +V TL ++ DRG F A+
Sbjct: 656 PPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTIN 715
Query: 934 GEDRGLIQLTVQE----------PPDPPELEIREVKARSMNLRWTQRFDGNSIITGFDIE 983
G L+ + P P L +R + S+ + WT + N ++ G+ I
Sbjct: 716 GTGPATDWLSAETFESDLDETRVPEVPSSLHVRPL-VTSIVVSWTPPENQNIVVRGYAIG 774
Query: 984 YKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTIS--- 1040
Y S T + I +L P+S Y I + +FN +G P E ++
Sbjct: 775 YGIGSP----HAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPH 830
Query: 1041 -----------------TEEAAPDGPPMDVTLQPVTSQSIQVTW--KAPKKELQNGVIRG 1081
+ P PP+ V ++ +I++TW + K + R
Sbjct: 831 TDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRY 890
Query: 1082 YQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEI 1141
Y + ++ N P +N +Y A + Y + LK Y V + S
Sbjct: 891 YTVRWKTNIP-ANTKYK----NANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTA 945
Query: 1142 NATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGE 1201
+ TT E VP+ PP++V +S I + P S NG + GY +I++S V+ E +
Sbjct: 946 HGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGY-IIYYSTDVNAEIHD 1004
Query: 1202 --MQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQT 1246
++ + R +++ + T Y ++ A G G S + +T
Sbjct: 1005 WVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRT 1051
Score = 125 bits (313), Expect = 6e-28
Identities = 183/845 (21%), Positives = 337/845 (39%), Gaps = 111/845 (13%)
Query: 731 ASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSG 790
A + +A S + P F+V+P + + G + +LNCS P PK+ WK
Sbjct: 34 ARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWK------ 87
Query: 791 NPQQYHPVPLTGRIQILPNSSLLIRHVL-----EEDIGYYLCQAS-NGVGTDISKSMFLT 844
+ + R Q+LP+ SL I +V+ + D GYY C A+ +GT IS++ L
Sbjct: 88 KDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLI 147
Query: 845 VKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKG-DTVIDPDRVMRYAIATKD 903
V TS P + G+ LNC + +RWE+ ++ DRV++
Sbjct: 148 VAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKL-----P 202
Query: 904 NGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPEL-EIREVKARS 962
+G V+S A GD + C + S G + ++ ++ PDP + ++ +K S
Sbjct: 203 SGMLVISN-----ATEGDGGLYRC-VVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPS 256
Query: 963 MNLRWT-QRFDGNSIITGF---DIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVY 1018
+R Q + +G I++ ++ D + S R + I D+
Sbjct: 257 PLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAG 316
Query: 1019 SIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSI----QVTWKAPK--K 1072
+ + N E ELT+ +A P+ + S I +VT K K
Sbjct: 317 TYFCIADNGNETIEAQAELTV---QAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVK 373
Query: 1073 ELQNG----------VIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQY 1122
++NG +++ + + G Y + G+++ A
Sbjct: 374 WVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ----------AGA 423
Query: 1123 GVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGV 1182
+++ A TGP +PS P + V +L +++ ++W P S +G
Sbjct: 424 QLIILEHAPATTGP------------LPSAPRDVVASL-VSTRFIKLTW-RTPASDPHGD 469
Query: 1183 LKGYRVIFWSLYVDGEWGEMQNITTTRE-RVELRGMEKFTNYSVQVLAYTQAGDGVRSSV 1241
Y V + + E ++N + E +V ++ + T Y +V+A + G G S+
Sbjct: 470 NLTYSVFYTKEGIARE--RVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAP 527
Query: 1242 LYIQTKEDV--PGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPS 1299
L ++T+ +V PGP ++A +S +S+ V+W P NG I+ Y ++ G+ +
Sbjct: 528 LRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDK---- 583
Query: 1300 EYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKI------- 1352
E + Y I L + +Y V A G G S+ V + P+
Sbjct: 584 EQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLE 643
Query: 1353 ISFGGTVTTPWMKDVRLPCNSVGD-PAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLR 1411
+ ++ W P G +++ K S S + ++ +GT L +
Sbjct: 644 VRNSKSIMIHWQPPA--PATQNGQITGYKIRYRKASRKSDVTETL-------VSGTQLSQ 694
Query: 1412 AVKAEDSGYY------------TCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSI 1459
++ D G T AT+ +T +L P+ P + +SI
Sbjct: 695 LIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSI 754
Query: 1460 TLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKN 1519
++W P +N +RG+ + Y + S + + + +R + +++L + Y + L A N
Sbjct: 755 VVSWTPPENQNIVVRGYAIGYGI-GSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFN 813
Query: 1520 SVGSG 1524
+VG G
Sbjct: 814 NVGEG 818
Score = 113 bits (282), Expect = 2e-24
Identities = 136/575 (23%), Positives = 221/575 (38%), Gaps = 70/575 (12%)
Query: 53 RRIGPLYGMWLVTFLLL-------LDSLHKARPEDVGTSL------YFVNDSLQQVTFSS 99
RR+ WL LLL + + P+ G S+ YF+ + + ++
Sbjct: 8 RRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRG 67
Query: 100 SVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIH-- 157
S V++ C A PS + W D + ++ ++ QL P ++ +H
Sbjct: 68 S-SVILNCSAYSEPSPKIEW---KKDGTF-----LNLVSDDRRQLLPDGSLFISNVVHSK 118
Query: 158 ----DNDYF-CTAE-NAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSS 211
D Y+ C A + G I S ++ +T + E GN A+ C + +
Sbjct: 119 HNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNAD 178
Query: 212 VQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQS 271
+ V V WE++ ++ + R G L IS+ + D YRC+ + G + S
Sbjct: 179 L---VPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDG-GLYRCVVES--GGPPKYS 232
Query: 272 NGARLSVTDPAESIPTILDGFHSQEV----WAGHTVELPCTASGYPIPAIRWLKDGRPLP 327
+ L V E I ++ F Q G V LPC ASG P P I+W+K+ L
Sbjct: 233 DEVELKVLPDPEVISDLV--FLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALD 290
Query: 328 ADSRWTKRIT-----GLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPK 382
+S ++R+ L ISD+ +D+GTY C N + EA L V P
Sbjct: 291 TES--SERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPT 348
Query: 383 KLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSG 442
+ ++ C +TG P T++W +N ++V+P + I + L + KS G
Sbjct: 349 NIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKI--VKEHNLQVLGLVKSDEG 406
Query: 443 AYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
YQC A AQ A + + + P P ++ + +TW
Sbjct: 407 FYQCIAENDVGNAQAGAQLIILEHAPATTGPL------PSAPRDVVASLVSTRFIKLTWR 460
Query: 503 LDDEPIVRDGSHRTNQYT--------MSDGTTISHMNVTGPQIRDGGVY--RCTARNLVG 552
D + YT + + + M VT + VY R A+N G
Sbjct: 461 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 520
Query: 553 SAEYQARINVRGPPSIR---AMRNITAVAGRDTLI 584
S E A + V P ++ N+ A A T I
Sbjct: 521 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSI 555
Score = 58.9 bits (141), Expect = 5e-08
Identities = 77/309 (24%), Positives = 116/309 (37%), Gaps = 17/309 (5%)
Query: 1331 AGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDS 1390
A GN + + E +A + + + D+ C G P P VKW K+ D
Sbjct: 322 ADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNG-DM 380
Query: 1391 AIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV--QVP----- 1443
IP D +++ + +L VK+ D G+Y C A N G L++ P
Sbjct: 381 VIP--SDYFKIVKEHNLQVLGLVKS-DEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437
Query: 1444 -PDQPR-LTVSKTSASSITLTW--IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERS 1499
P PR + S S I LTW D G ++ V + E + E
Sbjct: 438 LPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ 497
Query: 1500 FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINS-THARL 1558
+ +L T Y ++ A+N GSG S + +T +L + S T +
Sbjct: 498 VTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITV 557
Query: 1559 NLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAG 1618
+ +G I L Y KGT Q + SS + L++ T Y R+ A N G
Sbjct: 558 TWETPVSGNGEIQNYKLYYMEKGTDKEQDVDV-SSHSYTINGLKKYTEYSFRVVAYNKHG 616
Query: 1619 CGNETAQFA 1627
G T A
Sbjct: 617 PGVSTPDVA 625
Score = 53.9 bits (128), Expect = 2e-06
Identities = 54/213 (25%), Positives = 89/213 (41%), Gaps = 14/213 (6%)
Query: 1440 VQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERS 1499
VQ+P P L S +SIT+TW +G I+ + L Y +++ +DV +SS S
Sbjct: 536 VQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSS--HS 593
Query: 1500 FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLN 1559
+ ++ LK T Y ++ A N G G + + +T PS + NS ++
Sbjct: 594 YTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIH 653
Query: 1560 LQ----GWNNGGCPITAIVLEYR--PKGTWAWQGLRANSSGEVFLTELREATWYELRMRA 1613
Q NG IT + YR + + + L + + + L T Y R+ A
Sbjct: 654 WQPPAPATQNG--QITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAA 711
Query: 1614 CNSAGCGNET----AQFATLDYDGSTIPPIKSA 1642
G G T A+ D D + +P + S+
Sbjct: 712 LTINGTGPATDWLSAETFESDLDETRVPEVPSS 744
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 241 bits (614), Expect = 7e-63
Identities = 258/1008 (25%), Positives = 415/1008 (41%), Gaps = 95/1008 (9%)
Query: 161 YFCTAENAAGKIRSPNIRVKAVFREP--YTVRVEDQRSMRGNVAV-FKCLIPSSVQEYVS 217
Y C A N AGK + + +EP + ++E R ++ + ++C I S +
Sbjct: 7282 YTCYASNIAGK---DSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPE---I 7335
Query: 218 VVSWEKDTVSIIPEHRF---FITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGA 274
V W KD I +F F+ L + ++ ED+ Y C H +G S+
Sbjct: 7336 KVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDS-GDYTC-EAHNAAGSA--SSST 7391
Query: 275 RLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWT- 333
L V +P P H E G V L C G P + W KD R L + ++
Sbjct: 7392 SLKVKEP----PIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKI 7447
Query: 334 ---KRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGS 390
+T + I ++ D G Y C+ TN GS G + + P + T +G
Sbjct: 7448 MSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVVGK 7507
Query: 391 TVILSCALTGSPEFTIRWYRNT-ELVLPDEAISIRGLSN-ETLLITSAQKSHSGAYQCFA 448
V L + G+ ++ W+++ E+V + I I N TL + + +++G Y C
Sbjct: 7508 EVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQI 7567
Query: 449 TRKAQTAQDFAIIA-LEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEP 507
A + FA ++ LE T IV V G+ +L C G P + W D +
Sbjct: 7568 KNDAGMQECFATLSVLEPAT--IVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKE 7625
Query: 508 IVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG--- 564
+ D N+Y +S +S + + D GVY +N VG A + V
Sbjct: 7626 LTSD-----NKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTV 7680
Query: 565 PPSI-RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHR-QVVFENGTLKLT 622
PPS R ++ ++G ++ C+V G P S+ W+ + + + Q + T LT
Sbjct: 7681 PPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALT 7740
Query: 623 -DVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPP-LIQPFEFPPASIGQLLYIPCVVS 680
++ + D G+Y C + S S + V+ PP +Q + G + +V
Sbjct: 7741 VNMLEESDSGDYTC-IATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVK 7799
Query: 681 SGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSR 740
G P ++W K ++ G + ++ ++ L++ V +G YTCI SN A S
Sbjct: 7800 -GTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASC 7858
Query: 741 ERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPL 800
L ++ P +FV + N+ GK +L + G PP V WK + P Q +
Sbjct: 7859 TTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITT 7918
Query: 801 TGRIQIL--PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTT 858
T + IL P+S++ ED G Y C N G D + L ++ P +
Sbjct: 7919 TEKSAILEIPSSTV-------EDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVK 7971
Query: 859 IAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPAD 918
+++ G + L C G I + W KGDT + P Y + ++N V+TL D
Sbjct: 7972 VSV-GDSASLQCQLAGTPEIGVSWYKGDTKLRP--TTTYKMHFRNN----VATLVFNQVD 8024
Query: 919 RGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPEL--EIREVKAR-SMNLRWTQRFDGNS 975
DS + C A NS GE LTVQE PP ++R+V+ + + + G+
Sbjct: 8025 INDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSE 8084
Query: 976 -IITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPS 1034
I + + K DS + + S + + T+N D A YS + N IG + S
Sbjct: 8085 PISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFK-TDRSLAGQYSCT--ATNPIGSASSS 8141
Query: 1035 KELTISTEEAAPDGPPMDVTLQPVT---------------SQSIQVTWKAPKKELQNGVI 1079
L I TE P P D+ L PV +Q I+V+W +E+++G
Sbjct: 8142 ARL-ILTEGKNP--PFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSG-- 8196
Query: 1080 RGYQIGYRENS---------PGSNGQYSIVEMKATGDSEVYTLDNLKK 1118
YQI Y ENS G +GQY+ + G N+K+
Sbjct: 8197 GKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKE 8244
Score = 224 bits (571), Expect = 7e-58
Identities = 321/1413 (22%), Positives = 525/1413 (37%), Gaps = 145/1413 (10%)
Query: 87 FVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIR--HVHANGTLQL 144
F L+ V + V C GS + WY G + D +++ VH TLQ+
Sbjct: 7117 FFARKLKDVHETLGFPVAFECRINGSEPLQVSWY-KDGVLLKDDANLQTSFVHNVATLQI 7175
Query: 145 YPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREP--YTVRVEDQRSMRGNVA 202
S H Y C+A N G S + + P + ++ G
Sbjct: 7176 LQTDQS------HIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESG 7229
Query: 203 VFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITY---HGGLYISDVQKEDALSTYRCI 259
FKC + + ++W KD I P + +T L + V K DA Y C
Sbjct: 7230 TFKCHVTGTAP---IKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDA-GQYTCY 7285
Query: 260 TKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRW 319
+ + S A+L V +P I + S+ V C G P + W
Sbjct: 7286 ASNIAG---KDSCSAQLGVQEPPRFIKKLEP---SRIVKQDEFTRYECKIGGSPEIKVLW 7339
Query: 320 LKDGRPLPADSRW----TKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPL 375
KD + S++ + L + +L EDSG Y CE N GSA ++ L V +P
Sbjct: 7340 YKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPP 7399
Query: 376 HVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLL-IT 434
P ++T G+ V L C L G+P F + WY++ + + I + T + I
Sbjct: 7400 IFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHIL 7459
Query: 435 SAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGA 494
+ + G YQC AT + IAL+ PR V S+ G++ L +GA
Sbjct: 7460 NVDAADIGEYQCKATNDVGSDTCVGSIALK-APPRFVKKLSDISTVVGKEVQLQTTIEGA 7518
Query: 495 PPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSA 554
P +V W D IVR+ + Y+ + I+ + + + + G Y C +N G
Sbjct: 7519 EPISVVWFKDKGEIVRESDNIWISYSEN----IATLQFSRVEPANAGKYTCQIKNDAGMQ 7574
Query: 555 EYQARINVRGPPSI-RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDAL-LLPDNHRQV 612
E A ++V P +I +I G + C V G P S KW+KD L DN ++
Sbjct: 7575 ECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKI 7634
Query: 613 VFENGT--LKLTDVQKGMDEGEYLCSV---LIQPQLSISQSVHVAVKVPPLIQPFEFPPA 667
F N LK+ +V D G Y V + + + S V P + +
Sbjct: 7635 SFFNKVSGLKIINVAPS-DSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNG 7693
Query: 668 SIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNY 727
G + + C V G PI ++W +G I SG + +L ++ + +G+Y
Sbjct: 7694 LSGSSVVMECKVY-GSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDY 7752
Query: 728 TCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAK 787
TCIA+N A + L VR PP FV +P+ D + G V G PP V W
Sbjct: 7753 TCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGS 7812
Query: 788 GSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI 847
P V L + + L + V G Y C SN G S + L +K
Sbjct: 7813 SELVPGDRCNVSLEDSV-----AELELFDVDTSQSGEYTCIVSNEAGK-ASCTTHLYIKA 7866
Query: 848 PAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDE 907
PA N KG L T G PI + W+K + P + R I T +
Sbjct: 7867 PAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQ--RCNITTTEKS-- 7922
Query: 908 VVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP------DPPELEIREVKAR 961
+ L++ + D+ ++C+ N+ G+D Q+ + EPP +P ++ + + +
Sbjct: 7923 --AILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSASL 7980
Query: 962 SMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIR 1021
L T ++ + + K + + +K RN T+ N VD++ + Y +
Sbjct: 7981 QCQLAGTPEIG----VSWYKGDTKLRPTT-TYKMHFRNNVATL-VFNQVDINDSGEYICK 8034
Query: 1022 MYSFNKIGRSEPSKELTISTEEAAPD------------GPPMDVTLQPVTSQSIQVTWKA 1069
+ N +G S LT+ ++ P G P+ S+ I V+W
Sbjct: 8035 --AENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYK 8092
Query: 1070 PKKELQNGVIRGYQIGYRENSPGSN---------GQYSIVEMKATGDSEVYTLDNLKKFA 1120
K L++ Q + +N+ N GQYS G + L +
Sbjct: 8093 DGKPLKDSP--NVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTE-- 8148
Query: 1121 QYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLN 1180
G P +I ++ V + + ++ T + V SW++ R +
Sbjct: 8149 ------------GKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKV-SWAKDSREIRS 8195
Query: 1181 GVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSS 1240
G Y++ + + T +V+ ++T Y+V + +
Sbjct: 8196 G--GKYQISYLE----------NSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIK 8243
Query: 1241 VLYI---------QTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSP 1291
I +T E+ G ++ + + + V+W N + + T C
Sbjct: 8244 ERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYK----NNIEIQPTSNCEIT 8299
Query: 1292 GSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAK 1351
++ + L R A +N Y V+ AG + + I+ K P
Sbjct: 8300 ---------FKNNTLVLQVRKAGMNDAGLYTCKVS--NDAGSALCTSSIVIKEPKKPPV- 8347
Query: 1352 IISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLR 1411
VT + V+L C+ G ++W K + P L LR
Sbjct: 8348 FDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIK-PSDRCSFSFASGTAVLELR 8406
Query: 1412 AVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP 1444
V DSG Y C A+N G DT + ++ P
Sbjct: 8407 DVAKADSGDYVCKASNVAGSDTTKSKVTIKDKP 8439
Score = 220 bits (561), Expect = 1e-56
Identities = 313/1432 (21%), Positives = 548/1432 (38%), Gaps = 183/1432 (12%)
Query: 103 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHD---- 158
V + C +G+P + WY D +R + + Y + F++ IH
Sbjct: 5534 VSLECELSGTPPFEVVWYK-------DKRQLR------SSKKYKIASKNFHTSIHILNVD 5580
Query: 159 ----NDYFCTAENAAGKIRSPNIRVKAVFREP--YTVRVEDQRSMRGNVAVFKCLIPSSV 212
+Y C A+N G S +EP + ++ + G A + I +
Sbjct: 5581 TSDIGEYHCKAQNEVG---SDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQ 5637
Query: 213 QEYVSVVSWEKDTVSIIPE-HRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQS 271
+V W K+ +I E IT+ + K + + + I + K G R+
Sbjct: 5638 PIFVQ---WLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRE- 5693
Query: 272 NGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSR 331
N A L V +PA I++ V G T L C +G P ++ W KDG+ L + +
Sbjct: 5694 NMATLMVLEPA----VIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQK 5749
Query: 332 ----WTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLK-T 386
+ +I+ L I + +D+GTY +V N G + T ++ V D ++LK T
Sbjct: 5750 HKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNT 5809
Query: 387 G--IGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNE-TLLITSAQKSHSGA 443
G +G++ IL C + GS ++ W+ ++ N TL + S S G
Sbjct: 5810 GGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGN 5869
Query: 444 YQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWAL 503
Y C A A + + A++ +++ P V V PG+ + +G PP V W
Sbjct: 5870 YTCVAANVAGSDECRAVLTVQE-PPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFR 5928
Query: 504 DDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR 563
+V+ R N Y T++ + + I G Y C N G A R+ V+
Sbjct: 5929 GARELVK--GDRCNIYFED---TVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVK 5983
Query: 564 GPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLT 622
P + ++ + + + G+ ++ G S+ W KD + + + + +
Sbjct: 5984 EPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCIL 6043
Query: 623 DVQKGM--DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVS 680
++ D G+Y C + + + ++ ++ P + E A++G + + C V+
Sbjct: 6044 EILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVA 6103
Query: 681 SGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVS- 739
G I ++W K + +++L + V++ +G YTC A N+ T S
Sbjct: 6104 -GTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASS 6162
Query: 740 ------RERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQ 793
+ERQL PP F Q + + G L C ++G P +V W
Sbjct: 6163 KTVFRIQERQL----PPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCW---------- 6208
Query: 794 QYHPVPLTGRIQILPNS---SLLIRHVLEEDI---GYYLCQASNGVGTDISKSMFLTVKI 847
Y L + L S ++ +L+ D+ G Y C ASN +GT S S LT +
Sbjct: 6209 -YRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGT-ASSSARLTARE 6266
Query: 848 PA---MITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDN 904
P P + I G + + C G +P+ I W K + I P Y I N
Sbjct: 6267 PKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGG--NYTITCVGN 6324
Query: 905 GDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPD-PPELEIREVKARSM 963
L++ +GDS ++C A N G+D QL+V+EPP +LE +V +
Sbjct: 6325 TPH----LRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGE 6380
Query: 964 NLRWTQRFDGNSIITGFDIEYKNKSD---SWDFKQSTRNISPTINQANIVDLHPASVYSI 1020
+++ + G+ I ++N S+ SW + S IN ++ ++ AS
Sbjct: 6381 SIQLECKISGSPEIKVS--WFRNDSELHESWKYNMSF------INSVALLTINEASAEDS 6432
Query: 1021 RMY---SFNKIGRSEPSKELTIS-----TEEAAPDGP--PMDVTLQPVTSQS--IQVTWK 1068
Y + N +G + S LT+ T++ +P G DV LQ S + +V W
Sbjct: 6433 GDYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWV 6492
Query: 1069 APKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQA 1128
+K+++N ++ S + I+ ++A+ E + +A
Sbjct: 6493 KDRKQVRNSK------KFKITSKHFDTSLHILNLEASDVGEYHC--------------KA 6532
Query: 1129 FNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRV 1188
N G+ S + +PP V+ LS TS + L +++G++
Sbjct: 6533 TNEVGSDTCSCSVKF-------KEPPRFVKKLSDTSTLI------GDAVELRAIVEGFQP 6579
Query: 1189 IFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYS-VQVLAYTQAG--DGVRSSVLYIQ 1245
I ++ ++R E+ + T S + +A Q G + S Q
Sbjct: 6580 I--------------SVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQ 6625
Query: 1246 TKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSP 1305
K D + ++ P T G + + C G+ + + ++
Sbjct: 6626 IKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTG--NPFALECVVTGTPELSAKWFKDGR 6683
Query: 1306 E---QLFYRIAHLNRGQQYLLWVAAVTSAGR---------GNSSEKVTIEPAGK-APAKI 1352
E + I +N+ + A ++ G G S+ V++ + + P
Sbjct: 6684 ELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSF 6743
Query: 1353 ISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRA 1412
I V V L C G +V W +D + TL L
Sbjct: 6744 IRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSS-FSENVCTLNLSL 6802
Query: 1413 VKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP--DQPRLTVSKTSASSITLT 1462
++ D+G YTC A N G D L VQ PP +Q +V S+T T
Sbjct: 6803 LEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFT 6854
Score = 220 bits (560), Expect = 1e-56
Identities = 222/863 (25%), Positives = 358/863 (41%), Gaps = 68/863 (7%)
Query: 111 GSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAG 170
GS + W L D+I + +IR N LY HD Y C A+N AG
Sbjct: 4511 GSLPITVTW-LKDSDEITEDDNIRMTFENNVASLYLSGIEVK----HDGKYVCQAKNDAG 4565
Query: 171 KIR-SPNIRVKAVFREPYTVRVEDQRSM---RGNVAVFKCLIPSSVQEYVSVVSWEKDTV 226
R S + VK EP T+ E+ S+ +G+ A + S +E + W KD
Sbjct: 4566 IQRCSALLSVK----EPATI-TEEAVSIDVTQGDPATLQVKF-SGTKEITA--KWFKDGQ 4617
Query: 227 SIIPEHRFFITYHGGLYISDVQKEDALSTYRCI-TKHKYSGE---------TRQSNGARL 276
+ ++ I+ D +S + I T+ K SGE R S AR+
Sbjct: 4618 ELTLGSKYKISV-----------TDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARI 4666
Query: 277 SVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWT--- 333
+V D P+ + G ++L C +G +I+W KD + + A ++
Sbjct: 4667 NVLDLIIP-PSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSF 4725
Query: 334 -KRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTV 392
L IS L DSGTY C TN G + +G L V +P + P+ + V
Sbjct: 4726 HDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRV 4785
Query: 393 ILSCALTGSPEFTIRWYRNTELVLPDEAISI-RGLSNETLLITSAQKSHSGAYQCFATRK 451
L + G+ TI+W+++ + + A S+ + ++ +L + +A+ + SG Y C +
Sbjct: 4786 QLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSND 4845
Query: 452 AQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRD 511
TA A + +++ I V+ G+ + C G P V+W LD I
Sbjct: 4846 VGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAI 4905
Query: 512 GSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS-IRA 570
H + DG ++ ++G ++ + G Y C ARN G+A + V+ PP+ IR
Sbjct: 4906 QKH---GISFIDG--LATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRE 4960
Query: 571 MRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQK--GM 628
++ + V D + C V G P + + W K+ + + + + + ++ + K
Sbjct: 4961 LKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPS 5020
Query: 629 DEGEYLCSVLIQPQLSISQSVHVAVKVPP-LIQPFEFPPASIGQLLYIPCVVSSGDMPIR 687
D GEY C ++ S S S VA+K PP I+ E + V +G PI
Sbjct: 5021 DTGEYQC-IVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTV-AGSPPIS 5078
Query: 688 ITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVR 747
ITW KD Q++ V I + +++LQI SV H+G YTC A N + L+V+
Sbjct: 5079 ITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQ 5138
Query: 748 VPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQIL 807
P + V + + D L C V G P KV W P +Y + +
Sbjct: 5139 EPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNV--- 5195
Query: 808 PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMF--LTVKIPAMITSHPNTTIAIKGHA 865
+S I+ V+++D G Y + N G+ + L IP T + G +
Sbjct: 5196 --ASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSS 5253
Query: 866 KELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFF 925
+ C G PI +W K I R + E V+ L+L+ D+ +
Sbjct: 5254 IHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLE-VNNLELE-----DTANY 5307
Query: 926 SCHAINSYGEDRGLIQLTVQEPP 948
+C N G+D LTV+EPP
Sbjct: 5308 TCKVSNVAGDDACSGILTVKEPP 5330
Score = 220 bits (560), Expect = 1e-56
Identities = 319/1394 (22%), Positives = 532/1394 (38%), Gaps = 156/1394 (11%)
Query: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDN-DYFCTA 165
C +GS + +W+ G +I R V ++ L N + D +Y C
Sbjct: 5258 CKVSGSLPISAQWF-KDGKEISTSAKYRLVCHERSVSL-----EVNNLELEDTANYTCKV 5311
Query: 166 ENAAGKIRSPNIRVKAVFREP--YTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEK 223
N AG I +EP + V+ Q+++ + FK ++ + + W K
Sbjct: 5312 SNVAGDDACSGI---LTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPP---FKIKWFK 5365
Query: 224 DTVSIIPEHRFFITYHGGLYISDVQKEDALST--YRCITKHKYSGETRQSNGARLSVTDP 281
D V ++ + FI G ++ DA T Y C H + S L VT+P
Sbjct: 5366 DDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTC---HVTNDVGSDSCTTMLLVTEP 5422
Query: 282 AESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKR----IT 337
+ + + S+ V AG + L C +G P + W ++ LPA ++ +
Sbjct: 5423 PKFVKKLEA---SKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVA 5479
Query: 338 GLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCA 397
+ +++L TEDSG +ICE N GS + ++V +P + P ++T + V L C
Sbjct: 5480 VIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECE 5539
Query: 398 LTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLL-ITSAQKSHSGAYQCFATRKAQTAQ 456
L+G+P F + WY++ + + I + T + I + S G Y C A + +
Sbjct: 5540 LSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDT 5599
Query: 457 DFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRT 516
+ L++ PR VS + V GE L + +GA P V W + E ++R+ +
Sbjct: 5600 CVCTVKLKE-PPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIR 5658
Query: 517 NQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRN-IT 575
+ + T + + + G Y C +N G E A + V P I +T
Sbjct: 5659 ITFVENVAT----LQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMT 5714
Query: 576 AVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHR-QVVFEN--GTLKLTDVQKGMDEGE 632
G + C+V G P S++WYKD LL + + + F N +L++ V++ D G
Sbjct: 5715 VTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVER-QDAGT 5773
Query: 633 YLCSVLIQPQLSISQSVHVAV------KVPPLIQPFEFPPASIGQLLYIPCVVS---SGD 683
Y Q Q ++ +S AV VPP F + G +L C++ +G
Sbjct: 5774 YT----FQVQNNVGKSSCTAVVDVSDRAVPP---SFTRRLKNTGGVLGASCILECKVAGS 5826
Query: 684 MPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQ 743
PI + W + I+SG+ + + +LQ++S+ GNYTC+A+N A +
Sbjct: 5827 SPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAV 5886
Query: 744 LIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGR 803
L V+ PP FV +P + + GK + G PP KV W + R
Sbjct: 5887 LTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGA--------RELVKGDR 5938
Query: 804 IQILPNSSLLIRHVLEEDI---GYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIA 860
I ++ + DI G Y C SN G S + L VK PA +
Sbjct: 5939 CNIYFEDTVAELELFNIDISQSGEYTCVVSNNAG-QASCTTRLFVKEPAAFLKRLSDHSV 5997
Query: 861 IKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRG 920
G + L T G PI + W+K I K L++ + +
Sbjct: 5998 EPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEK------TCILEILNSTKR 6051
Query: 921 DSVFFSCHAINSYGED-RGLIQLTVQEPPDPPELE-IREVKARSMNLRWTQRFDGNSIIT 978
D+ +SC N G D G + T++ P ELE + S++L+ ++
Sbjct: 6052 DAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVS 6111
Query: 979 GFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELT 1038
+ + K + T N++ + N V+++ + Y+ + + N IG +
Sbjct: 6112 WYKGDTKLRPTPEYRTYFTNNVATLV--FNKVNINDSGEYTCK--AENSIGTASSKTVFR 6167
Query: 1039 ISTEEAAPD------------GPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGY 1086
I + P G P+ +T + S IQV W ++GV+
Sbjct: 6168 IQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCW------YRDGVL------L 6215
Query: 1087 RENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTL 1146
R++ N Q S V+ AT ++ D L QY A N GT SS+ + T
Sbjct: 6216 RDD---ENLQTSFVDNVAT--LKILQTD-LSHSGQYS--CSASNPLGTASSSARL---TA 6264
Query: 1147 EDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNIT 1206
+ P +++ +SI V+ G F +V G + IT
Sbjct: 6265 REPKKSPFFDIKPVSI------------------DVIAGESADF-ECHVTG--AQPMRIT 6303
Query: 1207 TTRERVELRGMEKFTNYSV------QVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAV 1260
+++ E+R +T V ++L + G + +D+ +K
Sbjct: 6304 WSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEP 6363
Query: 1261 PSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSP---EQLFYRIAHLNR 1317
P V L +K + C GS + S + E Y ++ +N
Sbjct: 6364 PK-----FVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINS 6418
Query: 1318 GQQYLLWVAAVTSAG-------RGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLP 1370
+ A+ +G G + KAP V DV L
Sbjct: 6419 VALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQ 6478
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
C G P V W KD + H + +L + ++A D G Y C ATN G
Sbjct: 6479 CEISGTPPFEVVWVKDRKQVRNSKKFK-ITSKHFDTSLHILNLEASDVGEYHCKATNEVG 6537
Query: 1431 FDTIIVNLLVQVPP 1444
DT ++ + PP
Sbjct: 6538 SDTCSCSVKFKEPP 6551
Score = 216 bits (551), Expect = 1e-55
Identities = 239/994 (24%), Positives = 387/994 (38%), Gaps = 97/994 (9%)
Query: 92 LQQVTFSSSVGVVVPCPAAGSPSAALRWY----LATGDDIYDVPHIRHVHANGTLQLYPF 147
L+ + + + V + C GS + WY L D+ + +V LQ
Sbjct: 6181 LKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQ---- 6236
Query: 148 SPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREP-----YTVRVEDQRSMRGNVA 202
H Y C+A N G S + REP + ++ + G A
Sbjct: 6237 -----TDLSHSGQYSCSASNPLGTASSS---ARLTAREPKKSPFFDIKPVSIDVIAGESA 6288
Query: 203 VFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG---LYISDVQKEDALSTYRCI 259
F+C + + ++ W KD I P + IT G L I V K D+ Y C
Sbjct: 6289 DFECHVTGAQPMRIT---WSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDS-GQYTCQ 6344
Query: 260 TKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRW 319
+ + A+LSV +P + + + S+ G +++L C SG P + W
Sbjct: 6345 ATNDVG---KDMCSAQLSVKEPPKFVKKLEA---SKVAKQGESIQLECKISGSPEIKVSW 6398
Query: 320 LKDGRPLPADSRWT----KRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPL 375
++ L ++ + LTI++ EDSG YICE N G A + L V P
Sbjct: 6399 FRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPP 6458
Query: 376 HVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLL-IT 434
T P + GS VIL C ++G+P F + W ++ + V + I +T L I
Sbjct: 6459 VFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHIL 6518
Query: 435 SAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGA 494
+ + S G Y C AT + + + ++ PR V S+ G+ L +G
Sbjct: 6519 NLEASDVGEYHCKATNEVGSDTCSCSVKFKE-PPRFVKKLSDTSTLIGDAVELRAIVEGF 6577
Query: 495 PPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSA 554
P +V W D ++R+ + + I+ + + P+ + G Y C +N G
Sbjct: 6578 QPISVVWLKDRGEVIRESENTRISFI----DNIATLQLGSPEASNSGKYICQIKNDAGMR 6633
Query: 555 EYQARINVRGPPSI-RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDAL-LLPDNHRQV 612
E A + V P I +T G + C V G P S KW+KD L D+ +
Sbjct: 6634 ECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHI 6693
Query: 613 VFEN--GTLKLTDVQKGMDEGEYLCSVLIQPQLS-ISQSVHVAVKV--PPLIQPFEFPPA 667
F N +LK+ + D+G Y V S + SVHV+ ++ P I+ + A
Sbjct: 6694 TFINKVASLKIPCAEMS-DKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNA 6752
Query: 668 SIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNY 727
+G + + C VS G PI + W +DG I+SG E + +L +S + G Y
Sbjct: 6753 ILGASVVLECRVS-GSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIY 6811
Query: 728 TCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAK 787
TC+A+N A + L V+ PP F P++ + + G + + G PP KV W
Sbjct: 6812 TCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGS 6871
Query: 788 GSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI 847
P + + L + + L + V + G Y C +N G+ S + L VK
Sbjct: 6872 RELVPGESCNISLEDFV-----TELELFEVQPLESGDYSCLVTNDAGS-ASCTTHLFVKE 6925
Query: 848 PAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDE 907
PA G L T G PI + W K + +I + K E
Sbjct: 6926 PATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILE 6985
Query: 908 VV-STLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP--------------DPPE 952
++ ST++ D +SC N G+D ++V EPP +P
Sbjct: 6986 ILESTIE-------DYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPAT 7038
Query: 953 LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDL 1012
L+ + + + W + + +++KN N++ + N VD
Sbjct: 7039 LQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKN------------NVASLV--INKVDH 7084
Query: 1013 HPASVYSIRMYSFNKIGRSEPSKELTISTEEAAP 1046
YS + + N +G S L I + P
Sbjct: 7085 SDVGEYSCK--ADNSVGAVASSAVLVIKARKLPP 7116
Score = 216 bits (550), Expect = 2e-55
Identities = 202/878 (23%), Positives = 357/878 (40%), Gaps = 62/878 (7%)
Query: 103 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYF 162
+ + C +GSP + W+ ++++ N L SA +S DY
Sbjct: 6382 IQLECKISGSPEIKVSWF-RNDSELHESWKYNMSFINSVALLTINEASAEDS----GDYI 6436
Query: 163 CTAENAAGKIR-SPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSW 221
C A N G S + VKA +T + +++G+ + +C I + V W
Sbjct: 6437 CEAHNGVGDASCSTALTVKAP--PVFTQKPSPVGALKGSDVILQCEISGTPP---FEVVW 6491
Query: 222 EKDTVSIIPEHRFFIT---YHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSV 278
KD + +F IT + L+I +++ D + Y C ++ +T + +
Sbjct: 6492 VKDRKQVRNSKKFKITSKHFDTSLHILNLEASD-VGEYHCKATNEVGSDTCSCS---VKF 6547
Query: 279 TDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTK---- 334
+P + + D G VEL G+ ++ WLKD + +S T+
Sbjct: 6548 KEPPRFVKKLSD----TSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFI 6603
Query: 335 -RITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVI 393
I L + +SG YIC++ N G E + +L V++P + P+ + G+
Sbjct: 6604 DNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFA 6663
Query: 394 LSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSN-ETLLITSAQKSHSGAYQCFATRKA 452
L C +TG+PE + +W+++ + D I ++ +L I A+ S G Y
Sbjct: 6664 LECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSV 6723
Query: 453 QTAQDFAIIALEDGT--PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVR 510
+ + + D P + + G L C G+ P +V W D IV
Sbjct: 6724 GKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIV- 6782
Query: 511 DGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI-R 569
S Q + S+ ++++ P D G+Y C A N+ GS E A + V+ PPS +
Sbjct: 6783 --SGPKCQSSFSENVCTLNLSLLEPS--DTGIYTCVAANVAGSDECSAVLTVQEPPSFEQ 6838
Query: 570 AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDAL-LLPDNHRQVVFENGT--LKLTDVQK 626
++ + G + G P + +KW+K + L+P + E+ L+L +VQ
Sbjct: 6839 TPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQP 6898
Query: 627 GMDEGEYLCSVLIQPQLSISQSVHVAVKVPP-LIQPFEFPPASIGQLLYIPCVVSSGDMP 685
++ G+Y C V S S + H+ VK P ++ G + + + G P
Sbjct: 6899 -LESGDYSCLVTNDAG-SASCTTHLFVKEPATFVKRLADFSVETGSPIVLEATYT-GTPP 6955
Query: 686 IRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLI 745
I ++W KD +I +I E + L+I +++ Y+C+ N A E +
Sbjct: 6956 ISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEALVS 7015
Query: 746 VRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMW--KHAKGSGNPQQYHPVPLTGR 803
V PP F+ + + + G+ L C VDG P ++ W +H K P +
Sbjct: 7016 VLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAY--------K 7067
Query: 804 IQILPN-SSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTV--KIPAMITSHPNTTIA 860
+Q N +SL+I V D+G Y C+A N VG S ++ + K+P
Sbjct: 7068 MQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHE 7127
Query: 861 IKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRG 920
G C G P+ + W K ++ D ++ + V+TL++ D+
Sbjct: 7128 TLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHN------VATLQILQTDQS 7181
Query: 921 DSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREV 958
++C A N G +L + E PP +++ V
Sbjct: 7182 HIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPV 7219
Score = 214 bits (544), Expect = 9e-55
Identities = 199/816 (24%), Positives = 319/816 (39%), Gaps = 69/816 (8%)
Query: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTV--RVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218
Y C AEN AG S + + +EP + R E + G+ A + + + +
Sbjct: 3994 YTCLAENEAGSQTSVG---ELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPE---LK 4047
Query: 219 VSWEKDTVSIIPEHRFFITYHG---------------GLYISDVQKEDALSTYRCITKHK 263
W KD ++ ++ I++ G Y ++ E S+ C T
Sbjct: 4048 PKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSS--CETTF- 4104
Query: 264 YSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDG 323
T T P ++ ++++G T L C +G + W KDG
Sbjct: 4105 ----TVLDRDIAPFFTKPLRNVDSVVNG----------TCRLDCKIAGSLPMRVSWFKDG 4150
Query: 324 RPLPADSRW----TKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTL 379
+ + A R+ + L I + D+G + C TN+ GS +++G L+V +P
Sbjct: 4151 KEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVT 4210
Query: 380 TPKKLKTGIGSTVILSCALTGSPEFTIRWYR-NTELVLPDEAISIRGLSNETLLITSAQK 438
P GS V L GS TIRW++ N ELV + +L + +
Sbjct: 4211 KPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKT 4270
Query: 439 SHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPT 498
S SG Y C + A + A + +++ + +++ G+ L C G PP
Sbjct: 4271 SDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPIK 4330
Query: 499 VTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQA 558
+TW +D I HR MS + + + +T I D G Y C A+N GS +
Sbjct: 4331 ITWFANDREIKESSKHR-----MSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSS 4385
Query: 559 RINVRGPPSI-RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENG 617
+ V+ P + + I + D ++ V G P + I W+KD +L + F
Sbjct: 4386 IVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQD 4445
Query: 618 TLKLTDVQK--GMDEGEYLCSVLIQPQLSISQSVHVAVKVPP-LIQPFEFPPASIGQLLY 674
L + K D GEY C V + SI S V ++ PP I+ E + G
Sbjct: 4446 HLVSLQILKFVAADAGEYQCRVTNEVGSSIC-SARVTLREPPSFIKKIESTSSLRGGTAA 4504
Query: 675 IPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNA 734
+ G +PI +TW KD I + + + ++SL +S + +KH+G Y C A N
Sbjct: 4505 FQATLK-GSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKND 4563
Query: 735 AATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQ 794
A L V+ P + + D G L G W
Sbjct: 4564 AGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGS 4623
Query: 795 YHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMF--LTVKIPAMIT 852
+ + +T + IL I ++D G Y + N VG K+ L + IP T
Sbjct: 4624 KYKISVTDTVSILK-----IISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFT 4678
Query: 853 SHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTL 912
+IKG +L C G PI I+W K D I +Y + DN + L
Sbjct: 4679 KKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASE--KYKFSFHDN----TAFL 4732
Query: 913 KLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
++ + DS ++C A N G ++ LTV+EPP
Sbjct: 4733 EISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPP 4768
Score = 214 bits (544), Expect = 9e-55
Identities = 249/1031 (24%), Positives = 423/1031 (41%), Gaps = 81/1031 (7%)
Query: 160 DYFCTAENAAGKIRSP-NIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218
+Y C A N G +I +KA R + ++ D ++ G + I + E +SV
Sbjct: 7468 EYQCKATNDVGSDTCVGSIALKAPPR--FVKKLSDISTVVGKEVQLQTTIEGA--EPISV 7523
Query: 219 VSWEKDTVSIIPEH-RFFITYHGG---LYISDVQKEDALSTYRCITKHKYSGETRQSNGA 274
V W KD I+ E +I+Y L S V+ +A Y C K+ Q A
Sbjct: 7524 V-WFKDKGEIVRESDNIWISYSENIATLQFSRVEPANA-GKYTCQIKNDAG---MQECFA 7578
Query: 275 RLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWT- 333
LSV +PA TI++ S +V G T L CT +G P + +W KDG+ L +D+++
Sbjct: 7579 TLSVLEPA----TIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKI 7634
Query: 334 ---KRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLK--TGI 388
+++GL I ++ DSG Y EV N G T L V D +KLK G+
Sbjct: 7635 SFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGL 7694
Query: 389 -GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNE-TLLITSAQKSHSGAYQC 446
GS+V++ C + GSP ++ W+ + N L + ++S SG Y C
Sbjct: 7695 SGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTC 7754
Query: 447 FATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDE 506
AT A + + A + + + P V V G + KG PP +V+W
Sbjct: 7755 IATNMAGSDECSAPLTVRE-PPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSS 7813
Query: 507 PIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPP 566
+V ++ +S +++ + + G Y C N G A + ++ P
Sbjct: 7814 ELVPG-----DRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPA 7868
Query: 567 S-IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQ 625
++ + + + G+ ++ G P S+ W K+ + + + R + + ++
Sbjct: 7869 KFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIP 7928
Query: 626 KGM--DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGD 683
D G+Y C + + + ++ P ++ E S+G + C ++ G
Sbjct: 7929 SSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSASLQCQLA-GT 7987
Query: 684 MPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQ 743
I ++W K + + + + +++L + V + +G Y C A N+ VS
Sbjct: 7988 PEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTF 8047
Query: 744 LIV---RVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPL 800
L V ++PP F Q + G V +C++ G P V W G P + P
Sbjct: 8048 LTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYK---DGKPLKDSPNVQ 8104
Query: 801 TGRIQILPNSSLLIRHVLEEDI-GYYLCQASNGVGTDISKSMFLTV--KIPAMITSHPNT 857
T L N++ L + + G Y C A+N +G+ S + + K P
Sbjct: 8105 TS---FLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAP 8161
Query: 858 TIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPA 917
A+ G + + C G +PI + W K I +Y I+ +N + L +
Sbjct: 8162 VDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGG--KYQISYLENS----AHLTVLKV 8215
Query: 918 DRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPEL------EIREVKARSMNLRWTQRF 971
D+GDS ++C+A+N G+D QL ++E PP + E + S L R
Sbjct: 8216 DKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLE--GRV 8273
Query: 972 DGNSIITGFDIEYKNKSDSWDFKQSTRNISPTI-NQANIVDLHPASVYSIRMYSFNKIGR 1030
G+ IT YKN + Q T N T N ++ + A + +Y+ K+
Sbjct: 8274 AGSQPIT--VAWYKNNIEI----QPTSNCEITFKNNTLVLQVRKAGMNDAGLYTC-KVSN 8326
Query: 1031 SEPSKELTISTEEAAPDGPPM-DVTLQPVT-SQSIQVTWKAPKKELQNGVIRGYQIGYRE 1088
S T S P PP+ D L PVT S+ V + + I+ + G RE
Sbjct: 8327 DAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAG-RE 8385
Query: 1089 NSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLED 1148
P +S A+G + V L ++ K V +A N AG+ + S++ T++D
Sbjct: 8386 IKPSDRCSFSF----ASG-TAVLELRDVAKADSGDYVCKASNVAGSDTTKSKV---TIKD 8437
Query: 1149 VPSQPPENVRA 1159
P+ P +A
Sbjct: 8438 KPAVAPATKKA 8448
Score = 206 bits (523), Expect = 3e-52
Identities = 186/746 (24%), Positives = 306/746 (41%), Gaps = 43/746 (5%)
Query: 219 VSWEKDTVSIIPEHRFFITYHGGLYISDVQ--KEDALSTYRCITKHKYSGETRQSNGARL 276
V+W KD + P + I + + ++ K TY C ++ S A +
Sbjct: 3675 VTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSS---SCSATV 3731
Query: 277 SVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI 336
+V +P + + + + G + L C G P+ + W K+ + L +
Sbjct: 3732 TVREPPSFVKKVDPSYL---MLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYF 3788
Query: 337 TG----LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTV 392
L I+D++ EDSG+Y CE N GS + +++ +P T + G+
Sbjct: 3789 VNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKTLEPADIVRGTNA 3848
Query: 393 ILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLL---ITSAQKSHSGAYQCFAT 449
+L C ++G+ F I W+++ + + + R S ++L+ I S + G Y+C
Sbjct: 3849 LLQCEVSGTGPFEISWFKDKKQIRSSK--KYRLFSQKSLVCLEIFSFNSADVGEYECVVA 3906
Query: 450 RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIV 509
+ A L++ P V + + G+ +L A +G+ P +VTW E I
Sbjct: 3907 NEVGKCGCMATHLLKE-PPTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIR 3965
Query: 510 RDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIR 569
DG + MS ++ + + QI GG Y C A N GS + V+ P I
Sbjct: 3966 EDGKIK-----MSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKII 4020
Query: 570 AMRNITAV-AGRDTLINCRVIGYPYYSIKWYKDAL-LLPDNHRQVVFENGTLKLTDVQKG 627
+ V AG + V G P KWYKD L+ ++ F+N +L
Sbjct: 4021 ERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAE 4080
Query: 628 M-DEGEYLCSVLIQPQLSISQSVHVAVK---VPPLIQPFEFPPASIGQLLYIPCVVSSGD 683
+ D G+Y + + S ++ + P +P + + + C ++ G
Sbjct: 4081 LHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIA-GS 4139
Query: 684 MPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQ 743
+P+R++W KDG+ I + I E +SL+I V + GN+TC A+N+ +
Sbjct: 4140 LPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGA 4199
Query: 744 LIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGR 803
LIV+ PP FV +P ++D + G A L + G P + W KG+ +T
Sbjct: 4200 LIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRW--FKGNKELVSGGSCYITKE 4257
Query: 804 IQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPA-MITSHPNTTIAIK 862
SSL + V D G Y C+ SN G + S L VK PA + + + K
Sbjct: 4258 AL---ESSLELYLVKTSDSGTYTCKVSNVAG-GVECSANLFVKEPATFVEKLEPSQLLKK 4313
Query: 863 GHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDS 922
G A +L C G PI I W D I R + E + L+L DS
Sbjct: 4314 GDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFV------ESTAVLRLTDVGIEDS 4367
Query: 923 VFFSCHAINSYGEDRGLIQLTVQEPP 948
+ C A N G D + V+E P
Sbjct: 4368 GEYMCEAQNEAGSDHCSSIVIVKESP 4393
Score = 201 bits (512), Expect = 5e-51
Identities = 316/1447 (21%), Positives = 537/1447 (37%), Gaps = 168/1447 (11%)
Query: 160 DYFCTAENAAGKIRSPNIRVKAVFREPYTV--RVEDQRSMRGNVAVFKCLIPSSVQEYVS 217
+Y C N GK + +EP T +V+D ++ G + + S E +S
Sbjct: 3900 EYECVVANEVGKC---GCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAVRGS--EPIS 3954
Query: 218 VVSWEKDTVSIIPEHRFFITYHGG---LYISDVQKEDALSTYRCITKHKYSGETRQSNGA 274
V +W K I + + +++ G L I DVQ Y C+ +++ +T +
Sbjct: 3955 V-TWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFG-GKYTCLAENEAGSQT---SVG 4009
Query: 275 RLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWT- 333
L V +PA+ I++ +V AG L T +G P +W KDGRPL A ++
Sbjct: 4010 ELIVKEPAK----IIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRI 4065
Query: 334 ---KRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLK---TG 387
+ L DSG Y E++N GS+ V+D K L+ +
Sbjct: 4066 SFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSV 4125
Query: 388 IGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLL-ITSAQKSHSGAYQC 446
+ T L C + GS + W+++ + + + I + L I + +G + C
Sbjct: 4126 VNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTC 4185
Query: 447 FATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDE 506
AT + + +++ P V+ K V PG L +G+ P T+ W ++
Sbjct: 4186 RATNSVGSKDSSGALIVQE-PPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNK 4244
Query: 507 PIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPP 566
+V GS + + + + + D G Y C N+ G E A + V+ P
Sbjct: 4245 ELVSGGSCYITKEALESSLELYLVKTS-----DSGTYTCKVSNVAGGVECSANLFVKEPA 4299
Query: 567 SIRAMRNITAVA--GRDTLINCRVIGYPYYSIKWYKDALLLPDN--HRQVVFEN-GTLKL 621
+ + + G T + C+V G P I W+ + + ++ HR E+ L+L
Sbjct: 4300 TFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRL 4359
Query: 622 TDVQKGM-DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVS 680
TDV G+ D GEY+C + S+ V VK P EF P + + + +
Sbjct: 4360 TDV--GIEDSGEYMCEAQNEAGSDHCSSI-VIVKESPYFTK-EFKPIEVLKEYDVMLLAE 4415
Query: 681 -SGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVS 739
+G P ITW KD ++ SG ++ + SLQI G Y C +N +
Sbjct: 4416 VAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSI 4475
Query: 740 RERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVP 799
++ +R PP F+ + + + G ++ G P V W K S + +
Sbjct: 4476 CSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTW--LKDSDEITEDDNIR 4533
Query: 800 LTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTI 859
+T + +SL + + + G Y+CQA N G ++ L+VK PA IT +
Sbjct: 4534 MTFENNV---ASLYLSGIEVKHDGKYVCQAKNDAGIQRCSAL-LSVKEPATITEEAVSID 4589
Query: 860 AIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADR 919
+G L G + I +W K + +Y I+ D VS LK+ ++
Sbjct: 4590 VTQGDPATLQVKFSGTKEITAKWFKDGQELTLGS--KYKISVTDT----VSILKIISTEK 4643
Query: 920 GDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRFDGNSIITG 979
DS ++ N G ++ V + PP + K S+ + D I+ G
Sbjct: 4644 KDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSF---IDLECIVAG 4700
Query: 980 F---------DIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGR 1030
D + + S+ + F I+Q D + Y+ + NK G
Sbjct: 4701 SHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTD---SGTYTCS--ATNKAGH 4755
Query: 1031 SEPSKELTISTE-------EAAPDGPPMDVTLQPVTSQSIQVT--WKAPKKELQNGVIRG 1081
++ S LT+ ++ P V L+ + + +T W KEL +G R
Sbjct: 4756 NQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARS 4815
Query: 1082 YQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEI 1141
+++++ S + KAT DS Y + Q N GT S + +
Sbjct: 4816 V---WKDDTSTS---LELFAAKAT-DSGTY-------------ICQLSNDVGTATSKATL 4855
Query: 1142 NATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGE 1201
+PP+ ++ S V+ +T + G I S Y+DG
Sbjct: 4856 FV-------KEPPQFIKKPS-----PVLVLRNGQSTTFECQITGTPKIRVSWYLDGN--- 4900
Query: 1202 MQNITTTRERVELRGMEKFTNYSVQVLAYTQ-AGDGVRSSVLYIQTKEDVPGPPAGIKAV 1260
E+ ++K + LA Q +G V +S Y+ + G
Sbjct: 4901 -----------EITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGT------- 4942
Query: 1261 PSSASSVVVSWLPPT-----KPNGVIRKYTIFCSSPGSGQPA-------------PSEYE 1302
+S S + PPT KP V++ + +G P S+
Sbjct: 4943 -ASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKY 5001
Query: 1303 TSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTP 1362
T +++ H+ + + G S T A K P I TT
Sbjct: 5002 TLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCST-RVALKEPPSFIKKIENTTTV 5060
Query: 1363 WMKDVRLPCNSVGDPAPAVKWTKDS----EDSAIPVSMDGHRLIHTNGTLLLRAVKAEDS 1418
G P ++ W KD ED + +S + + TL +R+V S
Sbjct: 5061 LKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISF-----VDSVATLQIRSVDNGHS 5115
Query: 1419 GYYTCTATNTGGFDTIIVNLLVQVPPD--QPRLTVSKTSASSITLTWIPGDNGGSSIRGF 1476
G YTC A N G + LLVQ P + +V T +TL + ++
Sbjct: 5116 GRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWL 5175
Query: 1477 VLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHG 1536
+ S + F ++ SF++ S+ + +N GS +
Sbjct: 5176 KDGKQIVPSRYFSMSF-ENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQN 5234
Query: 1537 REPSFSK 1543
PSF+K
Sbjct: 5235 IPPSFTK 5241
Score = 198 bits (503), Expect = 5e-50
Identities = 243/1028 (23%), Positives = 404/1028 (39%), Gaps = 133/1028 (12%)
Query: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIH--------D 158
C AGS +++W+ DD + + A+ + Y FS +F+
Sbjct: 4696 CIVAGSHPISIQWFK---DD-------QEISAS---EKYKFSFHDNTAFLEISQLEGTDS 4742
Query: 159 NDYFCTAENAAGKIR-SPNIRVKAVFREPYTVRVEDQRSMRGNVAV-FKCLIPSSVQEYV 216
Y C+A N AG + S ++ VK PY V + + N V K L+ +
Sbjct: 4743 GTYTCSATNKAGHNQCSGHLTVK---EPPYFVEKPQSQDVNPNTRVQLKALVGGTAP--- 4796
Query: 217 SVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALS-------------TYRCITKHK 263
+ W KD + H G S V K+D + TY C +
Sbjct: 4797 MTIKWFKDNKEL----------HSGAARS-VWKDDTSTSLELFAAKATDSGTYICQLSND 4845
Query: 264 YSGETRQSNGARLSVTDPAESI----PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRW 319
T + A L V +P + I P ++ + G + C +G P + W
Sbjct: 4846 VGTATSK---ATLFVKEPPQFIKKPSPVLV-------LRNGQSTTFECQITGTPKIRVSW 4895
Query: 320 LKDGRPLPA-DSRWTKRITGLT---ISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPL 375
DG + A I GL IS R E+SGTY+CE N G+A + L V +P
Sbjct: 4896 YLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPP 4955
Query: 376 HVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRG-LSNETLLIT 434
K ++ S V L C +TG+P F + W +N + + ++ +S L IT
Sbjct: 4956 TFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHIT 5015
Query: 435 SAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGA 494
S +G YQC + + + +AL++ P + + G+
Sbjct: 5016 KCDPSDTGEYQCIVSNEGGSCSCSTRVALKE-PPSFIKKIENTTTVLKSSATFQSTVAGS 5074
Query: 495 PPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSA 554
PP ++TW DD+ + D N Y +S +++ + + G Y C A+N G
Sbjct: 5075 PPISITWLKDDQILDEDD----NVY-ISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVE 5129
Query: 555 EYQARINVRGPPSIRAMRNITAVAGRDTL-INCRVIGYPYYSIKWYKDAL-LLPDNHRQV 612
A + V+ P I V +D + + C V G P +KW KD ++P + +
Sbjct: 5130 RCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSM 5189
Query: 613 VFENG--TLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAV---KVPP-LIQPFEFPP 666
FEN + ++ V K D G+Y V S S ++ V +PP +
Sbjct: 5190 SFENNVASFRIQSVMK-QDSGQYTFKVE-NDFGSSSCDAYLRVLDQNIPPSFTKKLTKMD 5247
Query: 667 ASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGN 726
+G +++ C VS G +PI W KDG+ I + + + E SL+++++ L+ N
Sbjct: 5248 KVLGSSIHMECKVS-GSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTAN 5306
Query: 727 YTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMW--K 784
YTC SN A + L V+ PP F+V+P Q I + G PP K+ W
Sbjct: 5307 YTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKD 5366
Query: 785 HAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLT 844
+ P+ + + L G S L + V G Y C +N VG+D +M L
Sbjct: 5367 DVELVSGPKCF--IGLEG-----STSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLV 5419
Query: 845 VKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDN 904
+ P + + I G + L C G I + W + + + R
Sbjct: 5420 TEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFI---- 5475
Query: 905 GDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP----DPPELEIREVKA 960
+ V+ +++ DS F C A N G ++ V+EPP PP +E +
Sbjct: 5476 --DSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAE 5533
Query: 961 RSM--NLRWTQRFDGNSIITGFDIEYKNK---SDSWDFKQSTRNISPTINQANIVDLHPA 1015
S+ L T F+ + YK+K S +K +++N +I +I+++ +
Sbjct: 5534 VSLECELSGTPPFE--------VVWYKDKRQLRSSKKYKIASKNFHTSI---HILNVDTS 5582
Query: 1016 SVYSIRMYSFNKIGR---------SEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVT 1066
+ + N++G EP + ++ G P ++ +Q I V
Sbjct: 5583 DIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQ 5642
Query: 1067 WKAPKKEL 1074
W K+E+
Sbjct: 5643 WLKEKEEV 5650
Score = 198 bits (503), Expect = 5e-50
Identities = 212/885 (23%), Positives = 354/885 (40%), Gaps = 73/885 (8%)
Query: 93 QQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPH-IRHVHANGTLQLYPFSPSA 151
+ +T ++ + C G+P + +W+ + D H I ++ +L++ P A
Sbjct: 6652 EPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLKI----PCA 6707
Query: 152 FNSFIHDNDYFCTAENAAGKIR-SPNIRVKAVFREPYTVR-VEDQRSMRGNVAVFKCLIP 209
S Y +N+ GK + ++ V P +R ++D ++ G V +C +
Sbjct: 6708 EMS--DKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVS 6765
Query: 210 SSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG---LYISDVQKEDALSTYRCITKHKYSG 266
S V W +D I+ + ++ L +S ++ D Y C+ +
Sbjct: 6766 GSAP---ISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDT-GIYTCVAANVAGS 6821
Query: 267 ETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPL 326
+ A L+V +P P+ S EV G ++ G P ++W K R L
Sbjct: 6822 D---ECSAVLTVQEP----PSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSREL 6874
Query: 327 -PADS---RWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPK 382
P +S +T L + +++ +SG Y C VTN GSA T L V +P
Sbjct: 6875 VPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLA 6934
Query: 383 KLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLL-ITSAQKSHS 441
GS ++L TG+P ++ W ++ L+ E SI T+L I +
Sbjct: 6935 DFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDY 6994
Query: 442 GAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTW 501
Y C +A A++++ + P + GE +L C G P ++W
Sbjct: 6995 AQYSCLIENEAGQDICEALVSVLE-PPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISW 7053
Query: 502 ALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARIN 561
+ + Y M ++ + + D G Y C A N VG+ A +
Sbjct: 7054 YKEHTKL-----RSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLV 7108
Query: 562 VRG---PPSI-RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDN-HRQVVFEN 616
++ PP R ++++ G CR+ G + WYKD +LL D+ + Q F +
Sbjct: 7109 IKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVH 7168
Query: 617 GTLKLTDVQKGMDE-GEYLCSVLIQPQLSISQSVHVAV---KVPPLIQPFEFPPASI--- 669
L +Q G+Y CS P + S S + + +VPP F+ P S+
Sbjct: 7169 NVATLQILQTDQSHIGQYNCSAS-NPLGTASSSAKLILSEHEVPPF---FDLKPVSVDLA 7224
Query: 670 -GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYT 728
G+ C V+ G PI+ITW KD + I G + E ++L + V G YT
Sbjct: 7225 LGESGTFKCHVT-GTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYT 7283
Query: 729 CIASNAAATVSRERQLIVRVPPRFV--VQPN---NQDGIYGKAGVLNCSVDGYPPPKVMW 783
C ASN A S QL V+ PPRF+ ++P+ QD + C + G P KV+W
Sbjct: 7284 CYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQD----EFTRYECKIGGSPEIKVLW 7339
Query: 784 KHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFL 843
+ + + +L +L + ED G Y C+A N G+ S S L
Sbjct: 7340 YKDETEIQESSKFRMSFVDSVAVLEMHNLSV-----EDSGDYTCEAHNAAGS-ASSSTSL 7393
Query: 844 TVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKD 903
VK P + P+ +KG L C +G P + W K R +R K
Sbjct: 7394 KVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYK------DKRELRSGKKYKI 7447
Query: 904 NGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
+ ++++ + D D + C A N G D + + ++ PP
Sbjct: 7448 MSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPP 7492
Score = 196 bits (497), Expect = 3e-49
Identities = 334/1536 (21%), Positives = 578/1536 (37%), Gaps = 214/1536 (13%)
Query: 92 LQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANG--TLQLYPFSP 149
L+ V VV+ C +GS ++ W+ G++I P + + TL L P
Sbjct: 6747 LKDVNAILGASVVLECRVSGSAPISVGWF-QDGNEIVSGPKCQSSFSENVCTLNLSLLEP 6805
Query: 150 SAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREP--YTVRVEDQRSMRGNVAVFKCL 207
S Y C A N AG S +EP + + + G F +
Sbjct: 6806 S------DTGIYTCVAANVAG---SDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSV 6856
Query: 208 IPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHG---GLYISDVQKEDALSTYRCITKHKY 264
I + V W K + ++P I+ L + +VQ ++ Y C+ +
Sbjct: 6857 IRGTPP---FKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLES-GDYSCLVTNDA 6912
Query: 265 SGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGR 324
+ ++ L V +PA + + D V G + L T +G P ++ W+KD
Sbjct: 6913 GSASCTTH---LFVKEPATFVKRLADF----SVETGSPIVLEATYTGTPPISVSWIKDEY 6965
Query: 325 PLPADSR----WTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLT 380
+ R T++ T L I + ED Y C + N G ++ V++P +
Sbjct: 6966 LISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEP 7025
Query: 381 PKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSN-ETLLITSAQKS 439
+ ++ IG L C + G+PE I WY+ + A ++ +N +L+I S
Sbjct: 7026 LEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHS 7085
Query: 440 HSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQF----SLMCAAKGAP 495
G Y C A A++ ++ ++ F+ K+ + E + C G+
Sbjct: 7086 DVGEYSCKADNSVGAVASSAVLVIK--ARKLPPFFARKLKDVHETLGFPVAFECRINGSE 7143
Query: 496 PPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAE 555
P V+W D + D + +T+ + + T+ + I G Y C+A N +G+A
Sbjct: 7144 PLQVSWYKDGVLLKDDANLQTS--FVHNVATLQILQTDQSHI---GQYNCSASNPLGTAS 7198
Query: 556 YQARINVRG---PPSIRAMR-NITAVAGRDTLINCRVIGYPYYSIKWYKD--ALLLPDNH 609
A++ + PP ++ G C V G I W KD + N+
Sbjct: 7199 SSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNY 7258
Query: 610 RQVVFEN-GTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPAS 668
+ + EN TL + V KG D G+Y C S S + V+ PP P
Sbjct: 7259 KMTLVENTATLTVLKVGKG-DAGQYTCYASNIAGKD-SCSAQLGVQEPPRFIKKLEPSRI 7316
Query: 669 IGQLLYIPCVVSSGDMP-IRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNY 727
+ Q + G P I++ W KD I S + + ++ L++ ++S++ +G+Y
Sbjct: 7317 VKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDY 7376
Query: 728 TCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMW---K 784
TC A NAA + S L V+ PP F +P+ + + G L C + G PP V W K
Sbjct: 7377 TCEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDK 7436
Query: 785 HAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLE---EDIGYYLCQASNGVGTDISKSM 841
SG + +I+ + L H+L DIG Y C+A+N VG+D
Sbjct: 7437 RELRSGK-----------KYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGS 7485
Query: 842 FLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRW--EKGDTVIDPDRVMRYAI 899
+ +K P + + G +L T G PI + W +KG+ V + D + I
Sbjct: 7486 -IALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIW---I 7541
Query: 900 ATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP---DPPE---- 952
+ +N ++TL+ + ++ ++C N G L+V EP + PE
Sbjct: 7542 SYSEN----IATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKV 7597
Query: 953 -------LEIREVKARSMNLRWTQRFDGNSIITG--FDIEYKNKSDSWDFKQSTRNISPT 1003
LE ++ +W + DG + + + I + NK
Sbjct: 7598 TTGDTCTLECTVAGTPELSTKWFK--DGKELTSDNKYKISFFNK---------------- 7639
Query: 1004 INQANIVDLHPAS--VYSIRMYSFNKIGRSEPSKELTISTEEAAPD------------GP 1049
++ I+++ P+ VYS + N +G+ + L +S P G
Sbjct: 7640 VSGLKIINVAPSDSGVYSFEVQ--NPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGS 7697
Query: 1050 PMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSE 1109
+ + + S I V+W E+ +G R YQ +N+ V M DS
Sbjct: 7698 SVVMECKVYGSPPISVSWFHEGNEISSG--RKYQTTLTDNTCALT-----VNMLEESDSG 7750
Query: 1110 VYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPS--QPPENVRALSITSDVA 1167
YT A N AG+ S+ + T+ + PS Q P+ + L+ T+
Sbjct: 7751 DYTCI-------------ATNMAGSDECSAPL---TVREPPSFVQKPDPMDVLTGTN--- 7791
Query: 1168 VISWSEPPRSTLNGVLKG---YRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYS 1224
T ++KG + V ++ + G+ N++ EL + T+ S
Sbjct: 7792 ---------VTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQS 7842
Query: 1225 VQV--LAYTQAGDGVRSSVLYIQTKEDV----------PGPPAGIKAVPSSASSVVVSWL 1272
+ + +AG ++ LYI+ G P ++ + + V+W
Sbjct: 7843 GEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTW- 7901
Query: 1273 PPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAG 1332
K NG+ + C+ + + A E +S + QY ++ ++G
Sbjct: 7902 ---KKNGINVTPSQRCNITTTEKSAILEIPSST---------VEDAGQYNCYIE--NASG 7947
Query: 1333 RGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAI 1392
+ + S ++ I P + V L C G P V W K +
Sbjct: 7948 KDSCSAQILI----LEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYK-GDTKLR 8002
Query: 1393 PVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQ---VPPDQPR- 1448
P + + TL+ V DSG Y C A N+ G + L VQ +PP R
Sbjct: 8003 PTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQ 8062
Query: 1449 -LTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSE--RSFKLDSL 1505
V +T + + S+ + + +S + F+ ++ FK D
Sbjct: 8063 LRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRS 8122
Query: 1506 KCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSF 1541
G + A N +GS S + T G+ P F
Sbjct: 8123 LAGQY---SCTATNPIGSASSSARL-ILTEGKNPPF 8154
Score = 182 bits (463), Expect = 2e-45
Identities = 210/913 (23%), Positives = 355/913 (38%), Gaps = 96/913 (10%)
Query: 92 LQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSA 151
L++ S VV+ C GSP ++ W+ G++I + + T L
Sbjct: 7688 LKETNGLSGSSVVMECKVYGSPPISVSWF-HEGNEISSGRKYQTTLTDNTCALTVNMLEE 7746
Query: 152 FNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREP--YTVRVEDQRSMRGNVAVFKCLIP 209
+S DY C A N AG S REP + + + + G F ++
Sbjct: 7747 SDS----GDYTCIATNMAG---SDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVK 7799
Query: 210 SSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG---LYISDVQKEDALSTYRCITKHKYSG 266
+ VSW K + ++P R ++ L + DV + Y CI ++
Sbjct: 7800 GTPP---FSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQS-GEYTCIVSNEAG- 7854
Query: 267 ETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPL 326
+ S L + PA+ + + D + G + L T +G P ++ W K+G +
Sbjct: 7855 --KASCTTHLYIKAPAKFVKRLND----YSIEKGKPLILEGTFTGTPPISVTWKKNGINV 7908
Query: 327 PADSRW----TKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPK 382
R T++ L I ED+G Y C + N G + +++++P + +
Sbjct: 7909 TPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLE 7968
Query: 383 KLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSN-ETLLITSAQKSHS 441
+K +G + L C L G+PE + WY+ + P + +N TL+ + S
Sbjct: 7969 PVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDS 8028
Query: 442 GAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLM----CAAKGAPPP 497
G Y C A + +++ ++ SFS ++ + E L CA G+ P
Sbjct: 8029 GEYICKAENSVGEVSASTFLTVQE--QKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPI 8086
Query: 498 TVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQ 557
+V+W D +P+ + +T+ D T ++ T + G Y CTA N +GSA
Sbjct: 8087 SVSWYKDGKPLKDSPNVQTS---FLDNTATLNIFKTDRSL--AGQYSCTATNPIGSASSS 8141
Query: 558 ARINV---RGPP--SIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQV 612
AR+ + + PP IR + + AV G C V G + W KD+ + +
Sbjct: 8142 ARLILTEGKNPPFFDIR-LAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQ 8200
Query: 613 V--FENGT-LKLTDVQKGMDEGEYLCSVLIQ-------PQLSISQSVHVAVKVPPLIQP- 661
+ EN L + V KG D G+Y C + + QL+I + + +PP
Sbjct: 8201 ISYLENSAHLTVLKVDKG-DSGQYTCYAVNEVGKDSCTAQLNIKERL-----IPPSFTKR 8254
Query: 662 -FEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVS 720
E + G + V+ G PI + W K+ I S I K LQ+
Sbjct: 8255 LSETVEETEGNSFKLEGRVA-GSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAG 8313
Query: 721 LKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGV---LNCSVDGYP 777
+ G YTC SN A + ++++ P + V + + G L+C V G
Sbjct: 8314 MNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSE 8373
Query: 778 PPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDI 837
P ++ W A P +L +R V + D G Y+C+ASN G+D
Sbjct: 8374 PIRIQWLKAGREIKPSDRCSFSFASGTAVLE-----LRDVAKADSGDYVCKASNVAGSDT 8428
Query: 838 SKSMFLTVKIPAM--------------ITSHPNTTIAIKGHAKELNCTARGERPIIIRWE 883
+KS PA+ S P + ++ G+ ++W
Sbjct: 8429 TKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWT 8488
Query: 884 KGD--TVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQ 941
KG + RV + GDE + L+++ + DS + C A N +GE +
Sbjct: 8489 KGKWRQLNQGGRVFIH-----QKGDE--AKLEIRDTTKTDSGLYRCVAFNEHGEIESNVN 8541
Query: 942 LTVQEPPDPPELE 954
L V E ++E
Sbjct: 8542 LQVDERKKQEKIE 8554
Score = 182 bits (461), Expect = 4e-45
Identities = 214/895 (23%), Positives = 352/895 (39%), Gaps = 81/895 (9%)
Query: 86 YFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGD-DIYDVPHIRHVHANGTLQL 144
YFV + L+ + + V + C AG+P + WY GD + P R N L
Sbjct: 6080 YFVTE-LEPLEAAVGDSVSLQCQVAGTPEITVSWY--KGDTKLRPTPEYRTYFTNNVATL 6136
Query: 145 YPFSPSAFNSF-IHDN-DYFCTAENAAGKIRSPNIRVKAVFR-------EPYTVRVEDQR 195
FN I+D+ +Y C AEN+ G S K VFR + +++D
Sbjct: 6137 ------VFNKVNINDSGEYTCKAENSIGTASS-----KTVFRIQERQLPPSFARQLKDIE 6185
Query: 196 SMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALST 255
G C + S V W +D V + + ++ + + + D +
Sbjct: 6186 QTVGLPVTLTCRLNGSAP---IQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHS 6242
Query: 256 --YRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYP 313
Y C + S+ ARL+ +P +S P S +V AG + + C +G
Sbjct: 6243 GQYSCSASNPLG---TASSSARLTAREPKKS-PFFDIKPVSIDVIAGESADFECHVTGAQ 6298
Query: 314 IPAIRWLKDGRPLPADSRWTKRITG----LTISDLRTEDSGTYICEVTNTFGSAEATGIL 369
I W KD + + +T G L I + DSG Y C+ TN G + L
Sbjct: 6299 PMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQL 6358
Query: 370 MVIDPLHVTLTPKKLKTG----IGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRG 425
V +P KKL+ G ++ L C ++GSPE + W+RN + ++
Sbjct: 6359 SVKEPPKFV---KKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSF 6415
Query: 426 LSNETLL-ITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQ 484
+++ LL I A SG Y C A A + ++ P S G
Sbjct: 6416 INSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVK-APPVFTQKPSPVGALKGSD 6474
Query: 485 FSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYR 544
L C G PP V W D + + + ++ ++ + +++ + D G Y
Sbjct: 6475 VILQCEISGTPPFEVVWVKDRKQV-----RNSKKFKITSKHFDTSLHILNLEASDVGEYH 6529
Query: 545 CTARNLVGSAEYQARINVRGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKD-- 601
C A N VGS + + PP ++ + + + + G + V G+ S+ W KD
Sbjct: 6530 CKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRG 6589
Query: 602 -ALLLPDNHRQVVFEN-GTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLI 659
+ +N R +N TL+L + + G+Y+C + + +V ++ +I
Sbjct: 6590 EVIRESENTRISFIDNIATLQLGS-PEASNSGKYICQIKNDAGMRECSAVLTVLEPARII 6648
Query: 660 QPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSV 719
+ E + G + CVV +G + W KDG+ + + S I ++SL+I
Sbjct: 6649 EKPEPMTVTTGNPFALECVV-TGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCA 6707
Query: 720 SLKHNGNYTCIASNAAATVSRERQLIVR---VPPRFVVQPNNQDGIYGKAGVLNCSVDGY 776
+ G Y+ N+ + + V VPP F+ + + + I G + VL C V G
Sbjct: 6708 EMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGS 6767
Query: 777 PPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLE-EDIGYYLCQASNGVGT 835
P V W GN P + N L +LE D G Y C A+N G+
Sbjct: 6768 APISVGWFQ---DGNEIVSGP---KCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGS 6821
Query: 836 DISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVM 895
D S LTV+ P P++ + G + RG P ++W KG + P
Sbjct: 6822 D-ECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESC 6880
Query: 896 RYAIATKDNGDEVVSTLKL---KPADRGDSVFFSCHAINSYGEDRGLIQLTVQEP 947
++ ++ V+ L+L +P + GD +SC N G L V+EP
Sbjct: 6881 NISL------EDFVTELELFEVQPLESGD---YSCLVTNDAGSASCTTHLFVKEP 6926
Score = 167 bits (424), Expect = 8e-41
Identities = 310/1488 (20%), Positives = 558/1488 (37%), Gaps = 162/1488 (10%)
Query: 187 YTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG---LY 243
+T +EDQ G AV +C V + V W K+ I+ ++ I G L
Sbjct: 12287 FTKPLEDQTVEEGATAVLEC----EVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLV 12342
Query: 244 ISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDP-AESIPTILDGFHSQEVWAGHT 302
I D ED + TY C K L+V P E + + D ++ A
Sbjct: 12343 IHDCTPED-IKTYTCDAKDF-------KTSCNLNVVPPHVEFLRPLTDLQVREKEMARFE 12394
Query: 303 VELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG----LTISDLRTEDSGTYICEVTN 358
EL + ++W KDG + ++ G L I+ +D Y CEV
Sbjct: 12395 CELSRENA-----KVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVR- 12448
Query: 359 TFGSAEATGILMVIDPLHV-TLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLP 417
+A +G+L V++ V T ++ T+ L C ++ P + WY+ E ++
Sbjct: 12449 ---TARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVS-KPGAEVIWYKGDEEIIE 12504
Query: 418 DEAISIRGLSNETLL-ITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSE 476
I + +L I +A +G Y C + +++ + + + +S
Sbjct: 12505 TGRYEILTEGRKRILVIQNAHLEDAGNYNC----RLPSSRTDGKVKVHELAAEFISKPQN 12560
Query: 477 KVVNPGEQFSLMCAAKGAPPPTVTWALDDEP--------IVRDGSHRTNQYTMSDGTTIS 528
+ GE+ +C+ P V W DD+ ++ DG R + D T
Sbjct: 12561 LEILEGEKAEFVCSISKESFP-VQWKRDDKTLESGDKYDVIADGKKRV--LVVKDAT--- 12614
Query: 529 HMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLI-NCR 587
++D G Y +VG+A A + V I T V + ++ NC
Sbjct: 12615 --------LQDMGTYVV----MVGAARAAAHLTVIEKLRIVVPLKDTRVKEQQEVVFNCE 12662
Query: 588 VIGYPYYSIKWYKDALLLPDNHRQVVFENG---TLKLTDVQKGMDEGEYLCSVLIQPQLS 644
V KW+++ + D+ + ++ + TL++ D D+ Y S+ +
Sbjct: 12663 V-NTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLD-DQANYNVSLTNHRGEN 12720
Query: 645 ISQSVHVAVKVPPL--IQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSG 702
+ + ++ V+ L ++P + + + C V+ + + + W K+G+ + +
Sbjct: 12721 VKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVNR--LNVTLKWTKNGEEVPFDNR 12778
Query: 703 VTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGI 762
V+ ++ L I G Y A + LI+ P FV +Q
Sbjct: 12779 VSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAEL---LIIEAPTEFVEHLEDQTVT 12835
Query: 763 YGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDI 822
V +C + +++ + ++Y G I L+I+ +D
Sbjct: 12836 EFDDAVFSCQLSREKANVKWYRNGREIKEGKKYK-FEKDGSIH-----RLIIKDCRLDDE 12889
Query: 823 GYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRW 882
Y C GV S++ +IP I P + G A + + + ++W
Sbjct: 12890 CEYAC----GVEDRKSRARLFVEEIPVEIIRPPQDILEAPG-ADVVFLAELNKDKVEVQW 12944
Query: 883 EKGDTVI---DPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGL 939
+ + V+ D ++M + + +KP D+G+ F I E R
Sbjct: 12945 LRNNMVVVQGDKHQMM------SEGKIHRLQICDIKPRDQGEYRF-----IAKDKEARAK 12993
Query: 940 IQLTVQEPPDPPELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQ---- 995
++L + ++ + + + + +D Y W FK+
Sbjct: 12994 LELAAAPKIKTADQDLVVDVGKPLTM-----------VVPYDA-YPKAEAEW-FKENEPL 13040
Query: 996 STRNISPTINQAN--IVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDV 1053
ST+ I T Q + I++ ++ NK G++E L + GP ++
Sbjct: 13041 STKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVP----GPVRNL 13096
Query: 1054 TLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTL 1113
+ + + W+ P + + +I GY + R+ + + V +S +T+
Sbjct: 13097 EVTETFDGEVSLAWEEPLTDGGSKII-GYVVERRDIK-----RKTWVLATDRAESCEFTV 13150
Query: 1114 DNLKKFA-QYGVVVQAFNRAGTGP---SSSEINATTLEDVPSQPPENVRALSITSDVAVI 1169
L+K +Y V A NR GTG + + + A + DVP PP NV + +
Sbjct: 13151 TGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPG-PPLNVTITDVNRFGVSL 13209
Query: 1170 SWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLA 1229
+W EPP + Y VI W + + + + YS +V A
Sbjct: 13210 TW-EPPEYDGGAEITNY-VIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRA 13267
Query: 1230 YTQAGDGVRSSVL-YIQTKEDV--PGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IRKYT 1285
+ G G S+ +++ + + P PP + + + SSV + W PP K G I Y
Sbjct: 13268 QNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYI 13327
Query: 1286 IFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE---KVTI 1342
I G + PE L Y++ L +G +YL V+A AG + SE +T
Sbjct: 13328 IERCEEGKDNWIRCNMKLVPE-LTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTA 13386
Query: 1343 EPAGKAPAKIISF---GGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE--DSAIPVSMD 1397
+ A P +S G V P + +P S G P P W + ++ V M
Sbjct: 13387 DDAFVEPTMDLSAFKDGLEVIVPNPITILVP--STGYPRPTATWCFGDKVLETGDRVKM- 13443
Query: 1398 GHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR-LTVSKTSA 1456
+ + L++ + D G YT N + +++ V P P+ L +
Sbjct: 13444 --KTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITK 13501
Query: 1457 SSITLTWIP-GDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKL 1515
S+ LTW P D+GGS + G+V++ + + W V ++ F + L G Y K+
Sbjct: 13502 DSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKEYLFKV 13561
Query: 1516 AAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGW----NNGGCPIT 1571
A+N G G ++ + P+ D A W N+GG I
Sbjct: 13562 CARNKCGPGE-PAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIK 13620
Query: 1572 AIVLEYRPKGTWAWQGL-RANSSGEVFLTELREATWYELRMRACNSAG 1618
++E P+G+ W + ++ +T L E WY R++A N G
Sbjct: 13621 GYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQG 13668
Score = 160 bits (406), Expect = 9e-39
Identities = 198/841 (23%), Positives = 321/841 (38%), Gaps = 91/841 (10%)
Query: 164 TAENAAGK---IRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVF---KCLIPSSVQEYVS 217
T + AGK + N+ +F E VR+ RS++ V V + ++ V E
Sbjct: 3119 TRMSDAGKYTVVAGGNVSTAKLFVEGRDVRI---RSIKKEVQVIEKQRAVVEFEVNEDDV 3175
Query: 218 VVSWEKDTVSII----PEHRFFITYH-GGLYISDVQKEDALSTYRCITKHKYSGETRQSN 272
W KD + I H++ + ++IS+ ++ DA Y + +G R S
Sbjct: 3176 DAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDA-GEYTFV-----AGRNRSSV 3229
Query: 273 GARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRW 332
++ +P P +L V +G SG P P I W K+ + L +
Sbjct: 3230 TLYVNAPEP----PQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKC 3285
Query: 333 TKRITG----LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVT---------- 378
G L + + ED+ Y CE N +G A + L V P V+
Sbjct: 3286 KFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPP 3345
Query: 379 --LTP-KKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLL-IT 434
+TP + T G C ++G+ + + WY + + P + + L I
Sbjct: 3346 AIITPLQDTVTSEGQPARFQCRVSGT-DLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIA 3404
Query: 435 SAQKSHSGAYQCFATRKAQTAQDFAIIALE------------------DGTPRIVSSFSE 476
A G Y A+ A ++LE P I
Sbjct: 3405 EAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEP 3464
Query: 477 KVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQ 536
V G C + AP W I + +++ ++ IS + + Q
Sbjct: 3465 LEVALGHLAKFTCEIQSAPNVRFQWFKAGREI-----YESDKCSIRSSKYISSLEILRTQ 3519
Query: 537 IRDGGVYRCTARNLVGSAEYQARINVRG---PPSIRAMRNITAVAGRDTLINCRVIGYPY 593
+ D G Y C A N GS A + V P + +++T G+ C V G P
Sbjct: 3520 VVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPV 3579
Query: 594 YSIKWYKD--ALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV 651
W KD AL N R EN + D G Y C + I Q+ +
Sbjct: 3580 IETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELI 3639
Query: 652 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM 711
+ P I+ E ++I + +++ C V D + +TW KDGQ + G I ++ +
Sbjct: 3640 IIDKPHFIKELEPVQSAINKKVHLECQVDE-DRKVTVTWSKDGQKLPPGKDYKICFEDKI 3698
Query: 712 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFV--VQPNNQDGIYGKAGVL 769
++L+I LK +G Y C ASN A + S + VR PP FV V P+ + G++ L
Sbjct: 3699 ATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYL-MLPGESARL 3757
Query: 770 NCSVDGYPPPKVMW-KHAKGSGNPQQYHPVPLTGRIQILPNSSLL-IRHVLEEDIGYYLC 827
+C + G P +V W K+ K T R+ + + ++L I V ED G Y C
Sbjct: 3758 HCKLKGSPVIQVTWFKNNKELSESN-------TVRMYFVNSEAILDITDVKVEDSGSYSC 3810
Query: 828 QASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDT 887
+A N VG+D S S + +K P ++G L C G P I W K
Sbjct: 3811 EAVNDVGSD-SCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKK 3869
Query: 888 VIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEP 947
I + +Y + ++ + + L++ + D + C N G+ + ++EP
Sbjct: 3870 QIRSSK--KYRLFSQKS----LVCLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEP 3923
Query: 948 P 948
P
Sbjct: 3924 P 3924
Score = 153 bits (386), Expect = 2e-36
Identities = 191/771 (24%), Positives = 305/771 (39%), Gaps = 97/771 (12%)
Query: 901 TKDNGDEVVS-TLKLKPADRGDSVFFSCHAINSYGE------DRGLIQLTVQEPPDPPEL 953
TK N ++ TLK G F AIN G + Q PP PP
Sbjct: 19535 TKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAF 19594
Query: 954 -EIREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNK-SDSWDFKQSTRNISPTINQANIV 1010
++ + S++L W + +DG S I G+ +E K SD+W +N+ T + +
Sbjct: 19595 PKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKT--RFEVT 19652
Query: 1011 DLHPASVYSIRMYSFNKIGRSEPS--------KELTISTE-EAAPD---------GPPMD 1052
L + Y R+Y+ NKIG S+PS K++ I E E D G M
Sbjct: 19653 GLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMR 19712
Query: 1053 VTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYT 1112
+ + ++TW P L++ +IG +++K+T
Sbjct: 19713 LYVPVKGRPPPKITWSKPNVNLRD------RIG--------------LDIKSTDFDTFLR 19752
Query: 1113 LDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWS 1172
+N+ K+ ++ N G + + D P PP NV I+ D A ++W
Sbjct: 19753 CENVNKYDAGKYILTLENSCGKKEYTIVVKVL---DTPG-PPVNVTVKEISKDSAYVTW- 19807
Query: 1173 EPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELR--GMEKFTNYSVQVLAY 1230
EPP + Y V D E +TT + R +E+ +Y +V A
Sbjct: 19808 EPPIIDGGSPIINYVV----QKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAE 19863
Query: 1231 TQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNG--VIRKYTIFC 1288
+ G G PGP +K S SS + W P G +I F
Sbjct: 19864 NEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFL 19923
Query: 1289 SSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKA 1348
+ Q L Y L G++Y V+A G G SE +T+
Sbjct: 19924 TEENKWQRVMKSLS-----LQYSAKDLTEGKEYTFRVSAENENGEGTPSE-ITVVARDDV 19977
Query: 1349 PAKIISFGGTVTTPWM----KDVRLPCNSVGDPAPAVKWTKDSEDSAIP--VSMDGHRLI 1402
A + G ++ + RL G PAP+V W K + A VS++ +
Sbjct: 19978 VAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAV- 20036
Query: 1403 HTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR--LTVSKTSASSIT 1460
N TL++ + D+G YT T N G +++ V P P + + +A ++T
Sbjct: 20037 --NTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMT 20094
Query: 1461 LTWIPG-DNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKN 1519
L W P D+GGS I ++L+ + +W + + +F++ L G Y +++A+N
Sbjct: 20095 LKWAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAEN 20154
Query: 1520 --SVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNN----GGCPITAI 1573
VG G SE I A+ P ++ ++ H ++L W + GG PIT
Sbjct: 20155 KYGVGEGLKSEPIVARHPFDVPDAPPPPNI---VDVRHDSVSLT-WTDPKKTGGSPITGY 20210
Query: 1574 VLEYRPKGTWAWQGLRANSS----GEVFLTELREATWYELRMRACNSAGCG 1620
LE++ + + W+ RAN + + +T L E YE R+ A N AG G
Sbjct: 20211 HLEFKERNSLLWK--RANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVG 20259
Score = 150 bits (379), Expect = 1e-35
Identities = 227/1002 (22%), Positives = 394/1002 (39%), Gaps = 121/1002 (12%)
Query: 681 SGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSR 740
SG P +TW + + + + TIE+ SS+ I + H G Y+ +A N A
Sbjct: 16549 SGKPPPTVTWNMNERTLPQEA--TIETTAISSSMVIKNCQRSHQGVYSLLAKNEAG---- 16602
Query: 741 ERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPP------PKVMWKHAKGSGNPQQ 794
ER+ + V V P + +C + + P P + K + +
Sbjct: 16603 ERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRA 16662
Query: 795 YHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN--GVGTDISKSMFLTVKIPAMIT 852
+ PV T + + ++ +++ ++ A N G+G + S L ++ P +
Sbjct: 16663 WTPVTYT-----VTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVP 16717
Query: 853 SHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVID---PDRVMRYAIATKDNGDEVV 909
P + +K K T P +++ G +I+ R++ K D ++
Sbjct: 16718 ERPED-LEVKEVTKN-TVTLTWNPP---KYDGGSEIINYVLESRLIGTEKFHKVTNDNLL 16772
Query: 910 ST-LKLKPADRGDSVFFSCHAINSYGEDRGLI---QLTVQEPPDPP--ELEIREVKARSM 963
S +K GD+ + A+N G+ + +T ++ PP L+ R+ +
Sbjct: 16773 SRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRD----KL 16828
Query: 964 NLRWTQRFDGNSIITGFDIE----YKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYS 1019
+R + F +G +K+++D + ++ +P + +
Sbjct: 16829 TIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGK 16888
Query: 1020 IRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKE----LQ 1075
+ N G + ++ + P GP V+ VT + ++WK P + +
Sbjct: 16889 YCVVVENSTGSRKGFCQVNVVDRPGPPVGP---VSFDEVTKDYMVISWKPPLDDGGSKIT 16945
Query: 1076 NGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYT--LDNLKKFAQYGVVVQAFNRAG 1133
N +I ++G V M T S T + L + Y + A N G
Sbjct: 16946 NYIIEKKEVG------------KDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYG 16993
Query: 1134 TGPS--SSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPP---RSTLNGVLKGYRV 1188
S + A VP P + + +T D A+++W++P + N +L+
Sbjct: 16994 ISDPLVSDSMKAKDRFRVPDAPDQPI-VTEVTKDSALVTWNKPHDGGKPITNYILEKRET 17052
Query: 1189 IF--WSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDG---VRSSVLY 1243
+ W+ + T R L G + Y +V A + G G S ++
Sbjct: 17053 MSKRWARVTKDP---IHPYTKFRVPDLLEGCQ----YEFRVSAENEIGIGDPSPPSKPVF 17105
Query: 1244 IQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEY- 1301
+ P PP +A+ ++ +SV ++W PP G I Y + G + + +
Sbjct: 17106 AKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHT 17165
Query: 1302 -ETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE-------KVTIEP------AGK 1347
E+ PE Y++ L GQ Y V AV +AG + + K +EP A
Sbjct: 17166 PESCPETK-YKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANM 17224
Query: 1348 APAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGT 1407
A + I G T+ RL G P P V W K+ D+ +D +
Sbjct: 17225 AREQHIKVGDTL--------RLSAIIKGVPFPKVTWKKEDRDAPTKARID---VTPVGSK 17273
Query: 1408 LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR-LTVSKTSASSITLTWI-P 1465
L +R ED G Y+ T N G T+ V +LV P PR L VS+ S LTW P
Sbjct: 17274 LEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEP 17333
Query: 1466 GDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGR 1525
D+GGS I +V++ S +W + +S ++S L G Y ++AA+N G G
Sbjct: 17334 LDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGP 17393
Query: 1526 ISEI---IEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWN----NGGCPITAIVLEYR 1578
E I+A P KD H H++ ++L WN +GG PIT ++EY+
Sbjct: 17394 FVETPKPIKALDPLHPPGPPKDLH---HVDVDKTEVSLV-WNKPDRDGGSPITGYLVEYQ 17449
Query: 1579 PKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCG 1620
+GT W + ++ E +T L++ Y R++A N G G
Sbjct: 17450 EEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLG 17491
Score = 149 bits (376), Expect = 3e-35
Identities = 265/1227 (21%), Positives = 447/1227 (36%), Gaps = 199/1227 (16%)
Query: 313 PIPAIRWLKDGRPLPADSRWT----KRITGLTISDLRTEDSGTYICEVTNTFGSAEATGI 368
P ++W+KD + L R K + L I R D+G Y T G +T
Sbjct: 3084 PDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKY----TVVAGGNVSTAK 3139
Query: 369 LMVID-PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYR-----NTELVLPDEAIS 422
L V + + K+++ ++ + + WY+ N ++ + +
Sbjct: 3140 LFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVN-EDDVDAHWYKDGIEINFQVQERHKYVV 3198
Query: 423 IRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPG 482
R + + I+ ++S +G Y A R + + P+++ V G
Sbjct: 3199 ERRIHR--MFISETRQSDAGEYTFVAGRNRSSV---TLYVNAPEPPQVLQELQPVTVQSG 3253
Query: 483 EQFSLMCAAKGAPPPTVTWALDDEPIVRDGS-----HRTNQYTMSDGTTISHMNVTGPQI 537
+ G P P ++W +E ++ G H +YT+ + P+
Sbjct: 3254 KPARFCAVISGRPQPKISW-YKEEQLLSTGFKCKFLHDGQEYTLL-------LIEAFPE- 3304
Query: 538 RDGGVYRCTARNLVGSAEYQARINVR--------------GPPSIRAMRNITAVAGRDTL 583
D VY C A+N G A A ++V P I +++ G+
Sbjct: 3305 -DAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPAR 3363
Query: 584 INCRVIGYPYYSIKWY-KDALLLPDNHRQVVFENGTLKLTDVQK-GMDEGEY-------L 634
CRV G + WY KD + P ++ T +L + DEG Y +
Sbjct: 3364 FQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAV 3422
Query: 635 CSVLIQPQLS-----------ISQSVHVAVKVPPLIQ-PFEFPPASIGQLLYIPCVVSSG 682
V LS I Q + + +K P+I+ E ++G L C + S
Sbjct: 3423 GQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSA 3482
Query: 683 DMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRER 742
+R W K G+ I +I S +++SSL+I + G YTC ASN +VS
Sbjct: 3483 PN-VRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTA 3541
Query: 743 QLIVR--VPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPL 800
L V PP F+ +P + GKA C+V G P + +W+ + +P +
Sbjct: 3542 TLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISD 3601
Query: 801 TGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIA 860
IL S+L I +D G Y C+ASN G DI ++ + + P I A
Sbjct: 3602 AENKHILELSNLTI-----QDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSA 3656
Query: 861 IKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRG 920
I L C +R + + W K + P + Y I +D ++TL++ A
Sbjct: 3657 INKKV-HLECQVDEDRKVTVTWSKDGQKLPPGK--DYKICFEDK----IATLEIPLAKLK 3709
Query: 921 DSVFFSCHAINSYGEDRGLIQLTVQEPP------DPPELEIREVKARSMNLRWTQRFDGN 974
DS + C A N G +TV+EPP DP L + AR + G+
Sbjct: 3710 DSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHC-----KLKGS 3764
Query: 975 SIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYS---FNKIGRS 1031
+I +KN + +S +N I+D+ V YS N +G
Sbjct: 3765 PVIQV--TWFKNNKE---LSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSD 3819
Query: 1032 EPSKELTIS-------TEEAAPDGPPMDVTLQPVTSQS--IQVTWKAPKKELQNGVIRGY 1082
S E+ I T E A + LQ S + +++W KK+++
Sbjct: 3820 SCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIR------- 3872
Query: 1083 QIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEIN 1142
S+ +Y + K+ E+++ ++ VV + G
Sbjct: 3873 ----------SSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVGKCGC-------M 3915
Query: 1143 ATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEM 1202
AT L +PP V+ + D+ + TL ++G S + W +
Sbjct: 3916 ATHLL---KEPPTFVKKVD---DLIALGGQTV---TLQAAVRG------SEPISVTWMKG 3960
Query: 1203 QNITTTRERVEL---RGMEKFTNYSVQV--------LAYTQAGDGVRSSVLYIQTKEDV- 1250
Q + ++++ G+ VQ+ LA +AG L ++ +
Sbjct: 3961 QEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKII 4020
Query: 1251 ---------PGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEY 1301
G PA ++ + + W +P +KY I +
Sbjct: 4021 ERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRI-------------SF 4067
Query: 1302 ETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAP--AKIISFGGTV 1359
+ + QL + A L+ QY ++ G + T+ AP K + +V
Sbjct: 4068 KNNVAQLKFYSAELHDSGQYTFEIS--NEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSV 4125
Query: 1360 TTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAE--D 1417
RL C G V W KD ++ A + D +R+ GT L ++ + D
Sbjct: 4126 VNG---TCRLDCKIAGSLPMRVSWFKDGKEIA---ASDRYRIAFVEGTASLEIIRVDMND 4179
Query: 1418 SGYYTCTATNTGGFDTIIVNLLVQVPP 1444
+G +TC ATN+ G L+VQ PP
Sbjct: 4180 AGNFTCRATNSVGSKDSSGALIVQEPP 4206
Score = 139 bits (349), Expect = 4e-32
Identities = 301/1447 (20%), Positives = 524/1447 (36%), Gaps = 200/1447 (13%)
Query: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKR----ITGLTI 341
P + F S V G +++ SG P P I W KDG PL +R +T L+I
Sbjct: 23230 PDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSI 23289
Query: 342 SDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSC---AL 398
+ +D G Y V N G A+ ++ +D P K ++ LS
Sbjct: 23290 KETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLY 23349
Query: 399 TGSPEFT--IRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQ 456
TG + T I R+T + D + ++ TL +T + ++ FA + Q
Sbjct: 23350 TGGCQITNYIVQKRDTTTTVWDVVSAT--VARTTLKVTKLKTGTEYQFRIFAENRY--GQ 23405
Query: 457 DFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRT 516
FA+ + P IV+ + K PG + A + W EP+ GS
Sbjct: 23406 SFAL----ESDP-IVAQYPYK--EPGPPGTPFATAISKDSMVIQW---HEPVNNGGSPVI 23455
Query: 517 NQYT-MSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI-RAMRNI 574
+ + +I V I D + A+NL EY+ R+ + +A +N
Sbjct: 23456 GYHLERKERNSILWTKVNKTIIHDT---QFKAQNLEEGIEYEFRVYAENIVGVGKASKNS 23512
Query: 575 TAVAGRDTLINCRVIGYPY--------YSIKWYK--------------DALLLPDNHRQV 612
RD C G P +++W K + LPD
Sbjct: 23513 ECYVARDP---CDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMK 23569
Query: 613 VFENGTLKLTDVQKGMDEGE-YLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQ 671
++ G+ E + Y V+ + + E P S+
Sbjct: 23570 ASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDP 23629
Query: 672 LLYIPCVVSSGDM----------PI-RITWRKDGQVIISGSGVTIESKEFMSSLQISSVS 720
VV++G+ P+ I W + + I + I++ +F + L +
Sbjct: 23630 KFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAI 23689
Query: 721 LKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLN--CSVDGYPP 778
G Y ASN A + S V + + +P +G GV + CS+ PP
Sbjct: 23690 RIDGGQYILRASNVAGSKS------FPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPP 23743
Query: 779 PKVMWKHAKGSGNPQQYHPVPL--TGRI-------QILPNSSLLIRHVLEEDIGYYLCQA 829
+ G+ ++ V T R+ +++ NS L + +LE + + A
Sbjct: 23744 -------LQDGGSDISHYVVEKRETSRLAWTVVASEVVTNS-LKVTKLLEGNEYVFRIMA 23795
Query: 830 SN--GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDT 887
N GVG + + L +K P ++ P K L T + + + W + D+
Sbjct: 23796 VNKYGVGEPLESAPVL-MKNPFVLPGPP----------KSLEVTNIAKDSMTVCWNRPDS 23844
Query: 888 VIDPDRVMRYAIATKDNGD--------EVVSTLKLKPADRGDS--VFFSCHAINSYGEDR 937
++ Y + +D ++ L+L+ + F A N+ G
Sbjct: 23845 D-GGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGE 23903
Query: 938 GLIQLT-------VQEPPDPPELEIREVKARSMNLRWTQR-FDGNSIITGFDIEYKNKSD 989
V +P P I + S+ L W + +DG S I G+ +E K+D
Sbjct: 23904 PSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEIC-KAD 23962
Query: 990 SWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGP 1049
+++ T + + I L Y IR+ + NK+G E + E + P
Sbjct: 23963 EEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAP 24022
Query: 1050 PMD--------VTLQPVTSQSIQVTWKA-PKKELQNGVIRGYQIGYRENSPGSNGQYSIV 1100
+D + ++ S I + +K P E+ RE ++ V
Sbjct: 24023 ELDLDSELRKGIVVRAGGSARIHIPFKGRPTPEITWS---------REEGEFTDK----V 24069
Query: 1101 EMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRAL 1160
+++ + ++DN + +++ N +G S S + D P PP+N+
Sbjct: 24070 QIEKGVNYTQLSIDNCDRNDAGKYILKLENSSG---SKSAFVTVKVLDTPG-PPQNLAVK 24125
Query: 1161 SITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKF 1220
+ D A + W EPP +K Y + + T +VE + +
Sbjct: 24126 EVRKDSAFLVW-EPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVE--NLTEG 24182
Query: 1221 TNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV 1280
Y +V+A + G GV + + P PP + S +S + W P G
Sbjct: 24183 AIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGS 24242
Query: 1281 -IRKYTIFCSSPGSGQPAPSEYETSPEQLFYR--IAHLNRGQQYLLWVAAVTSAGRGNS- 1336
+ Y + G+ ++ E + L+ GQ+Y V A G+ +
Sbjct: 24243 RVLGYVVEMQPKGT-----EKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPR 24297
Query: 1337 -------SEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSED 1389
++ +TI+P+ K P S +D+++ +G P P + W KD E
Sbjct: 24298 VLGVPVIAKDLTIQPSLKLPFNTYSIQAG------EDLKIEIPVIGRPRPNISWVKDGEP 24351
Query: 1390 SAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQP-- 1447
++ T+ L ++ +D G YT TATN+ G T ++++V P P
Sbjct: 24352 LKQTTRVNVEETA-TSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVG 24410
Query: 1448 RLTVSKTSASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLK 1506
+ + SA + ++W P GG I ++++ + W V + + + K+ LK
Sbjct: 24411 PVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLK 24470
Query: 1507 CGTWYKVKLAAKNSVGSGR--ISEIIEAKTHGREP---------SFSKDQHLFTHINSTH 1555
GT Y+ ++ A+N G S+ + + +EP S SKDQ L
Sbjct: 24471 TGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPV- 24529
Query: 1556 ARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRAN--SSGEVFLTELREATWYELRMRA 1613
N+GG I LE + K + W L + T L E YE ++ A
Sbjct: 24530 --------NDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSA 24581
Query: 1614 CNSAGCG 1620
N G G
Sbjct: 24582 ENIVGIG 24588
Score = 135 bits (341), Expect = 3e-31
Identities = 148/616 (24%), Positives = 245/616 (39%), Gaps = 48/616 (7%)
Query: 1046 PDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENS----PGSNGQYSIVE 1101
P+GP + + VTS+ ++W P + I Y + RE S + + +
Sbjct: 21558 PEGP---LAVTEVTSEKCVLSWFPPLDD-GGAKIDHYIVQKRETSRLAWTNVASEVQVTK 21613
Query: 1102 MKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINATTLEDVPSQPPENVRAL 1160
+K T L K +Y V A N+ G G P SE P PP+N
Sbjct: 21614 LKVT---------KLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVT 21664
Query: 1161 SITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKF 1220
+IT D V+ W P + ++ ++ W + T T R ++ G+ +
Sbjct: 21665 TITKDSMVVCWGHPDSDGGSEIIN--YIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEG 21722
Query: 1221 TNYSVQVLAYTQAGDGVRSSVLYIQTKEDV---PGPPAGIKAVPSSASSVVVSWLPPTKP 1277
Y +++A AG S D PGPP + + +S SS+ ++W P
Sbjct: 21723 HEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYD 21782
Query: 1278 NGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNS 1336
G I Y + + P + + Y I L Q+Y + + A+ S G G
Sbjct: 21783 GGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLG-- 21840
Query: 1337 SEKVTIEPAGKAPAKII--------SFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE 1388
E + KA +++ VT +RL G PAP VKW +D
Sbjct: 21841 -EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHG 21899
Query: 1389 DSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR 1448
+S S++ + L++ V DSG Y T N+ G + VN+ V P P+
Sbjct: 21900 ESLDKASIES---TSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTPGPPQ 21956
Query: 1449 -LTVSKTSASSITLTWIPGD-NGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLK 1506
L V + + +S+TLTW P +GGS I+ ++++ + + V + + S+K+D L+
Sbjct: 21957 DLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQ 22016
Query: 1507 CGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGW--- 1563
G Y ++ A+N G G +E E+ P T ++ T ++L W
Sbjct: 22017 EGCSYYFRVLAENEYGIGLPAETAESVKASERP---LPPGKITLMDVTRNSVSL-SWEKP 22072
Query: 1564 -NNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCGNE 1622
++GG I ++E + KG+ W E +T L + Y R+ A N G +
Sbjct: 22073 EHDGGSRILGYIVEMQTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDP 22132
Query: 1623 TAQFATLDYDGSTIPP 1638
+ IPP
Sbjct: 22133 RQLSVPVIAKDLVIPP 22148
Score = 135 bits (340), Expect = 4e-31
Identities = 226/1010 (22%), Positives = 388/1010 (38%), Gaps = 119/1010 (11%)
Query: 669 IGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYT 728
+G L + ++ P ++TW+K+ + + + I+ S L+I + + + G Y+
Sbjct: 17232 VGDTLRLSAIIKGVPFP-KVTWKKEDRD--APTKARIDVTPVGSKLEIRNAAHEDGGIYS 17288
Query: 729 CIASNAAATVSRERQLIVRV---PPRFV-VQPNNQDGIY---------GKAGVLNCSVDG 775
N A + + +++V PPR + V +D Y G + + N V+
Sbjct: 17289 LTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVER 17348
Query: 776 YPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGT 835
W P+ T + S +H+ E + + A N G
Sbjct: 17349 RDVASAQWS------------PLSATSK-----KKSHFAKHLNEGNQYLFRVAAENQYG- 17390
Query: 836 DISKSMFLTVKIP--AMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDR 893
+ F+ P A+ HP G K+L+ + + + W K PDR
Sbjct: 17391 ---RGPFVETPKPIKALDPLHP------PGPPKDLHHVDVDKTEVSLVWNK------PDR 17435
Query: 894 -----VMRYAIATKDNGDE------VVSTLK--LKPADRGDSVFFSCHAINSYGEDRGLI 940
+ Y + ++ G + V+ L+ + +G + F A N G GL
Sbjct: 17436 DGGSPITGYLVEYQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVG--LGLP 17493
Query: 941 QLTV----QEPPDPP--ELEIREVKARSMNLRWTQRFDGNSIITGFDIEY-KNKSDSWDF 993
T+ QE PP EL+++ ++ + T RF +II G + K +D +
Sbjct: 17494 DTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFP--AIIRGVPVPTAKWTTDGSEI 17551
Query: 994 KQSTRNISPTINQANIVDLHPASVYSIRMYSF---NKIGRSEPSKELTISTEEAAPDGPP 1050
K T N ++++ + Y N G + LT+ P GP
Sbjct: 17552 KTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGP- 17610
Query: 1051 MDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEV 1110
+ + VT + + ++W+ PK + + VI Y + ++ + G S +G S+
Sbjct: 17611 --INILDVTPEHMTISWQPPKDDGGSPVIN-YIVEKQDTRKDTWGVVS------SGSSKT 17661
Query: 1111 -YTLDNLKKFAQYGVVVQAFNRAGTGPS-SSEINATTLEDVPSQPPENVRALSITSDVAV 1168
+ +L+K +Y V+A N+ G GP S + P PP IT + A
Sbjct: 17662 KLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT 17721
Query: 1169 ISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVL 1228
+SW+ P +S + GY + V G+W + + + G+ + Y +V
Sbjct: 17722 VSWTLP-KSDGGSPITGYYME--RREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVF 17778
Query: 1229 AYTQAG---DGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IRKY 1284
A AG S + PGPP K S + + W P G I Y
Sbjct: 17779 AENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGY 17838
Query: 1285 TIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE--KVTI 1342
+ C PG+ Q + Q +R+ L G +Y + A G G E + I
Sbjct: 17839 VVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVI 17898
Query: 1343 EPAGKAPAKI---ISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH 1399
P ++ ++ +T + +R+ G P P + WTK+ + +D
Sbjct: 17899 AKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLI 17958
Query: 1400 RLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF--DTIIVNLLVQVPPDQPRLTVSKTSAS 1457
+ + + AV+A D G Y +A N+ G + IVN+L + P Q L V+ +
Sbjct: 17959 QDLPRVELQIKEAVRA-DHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQ-NLKVTNVTKE 18016
Query: 1458 SITLTWI-PGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLA 1516
+ T++W P DNGGS I F+++Y N + W V ++R K + L +Y ++
Sbjct: 18017 NCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYY-FRVC 18075
Query: 1517 AKNSVGSGRISEIIEAKTH--GREPSFSKDQHLFTHINSTHARLNLQGWN----NGGCPI 1570
A+N VG G IE KT P + HI W +GG P
Sbjct: 18076 AENKVGVG---PTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPN 18132
Query: 1571 TAIVLEYRPKGTWAWQGLRANSSGEV--FLTELREATWYELRMRACNSAG 1618
+ +E R KG+ W+ + S E + E YE R++ N G
Sbjct: 18133 LSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNEGG 18182
Score = 132 bits (333), Expect = 3e-30
Identities = 159/611 (26%), Positives = 253/611 (41%), Gaps = 47/611 (7%)
Query: 1058 VTSQSIQVTWKAPKKELQNGV--IRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDN 1115
+T + + + W AP L +G I Y I RE S + ++++E K S YT
Sbjct: 28064 ITGEKMTLWWDAP---LNDGCAPITHYIIEKRETSRLA---WALIEDKCEAQS--YTAIK 28115
Query: 1116 LKKFAQYGVVVQAFNRAGTG------PSSSEINATTLEDVPSQP-PENVRALSITSDVAV 1168
L +Y V A N+ G G P ++I T + D P P P N+ SIT
Sbjct: 28116 LINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYT-VPDAPGIPEPSNITGNSIT----- 28169
Query: 1169 ISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRE-RVELRGMEKFTNYSVQV 1227
++W+ P S ++ Y ++ W ++ + E R ++ G+ + Y V
Sbjct: 28170 LTWARP-ESDGGSEIQQY-ILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHV 28227
Query: 1228 LAYTQAGDGVRSSVL-YIQTKEDV--PGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IRK 1283
+A AG G S + I+ +E V PGPP +K +S ++V + W P G+ I
Sbjct: 28228 MAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIG 28287
Query: 1284 YTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKV-TI 1342
Y I G E + Y + L G++Y V+A+ AG+G+S E TI
Sbjct: 28288 YIIEMCKADLGDWHKVNAEACVKTR-YTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTI 28346
Query: 1343 EPAGKAPAKII----SFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDG 1398
+ + A + +F T +RL G P P W+K DS + + D
Sbjct: 28347 KAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKP--DSNLSLRAD- 28403
Query: 1399 HRLIHTN---GTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR-LTVSKT 1454
IHT TL + D+G YT T N G +I + V P P +T
Sbjct: 28404 ---IHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDV 28460
Query: 1455 SASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKV 1513
+ S TL W P +GG+ I +V++ + W+ + + + FK++ L G Y
Sbjct: 28461 TRGSATLMWDAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYF 28520
Query: 1514 KLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAI 1573
+++A N G G E+ E +P+ + + S+ L+ ++GG IT
Sbjct: 28521 RVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGY 28580
Query: 1574 VLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCGNETAQFATLDYDG 1633
+LE R KG+ W + L E T YE R++A N AG F+++
Sbjct: 28581 LLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKE 28640
Query: 1634 STIPPIKSAQG 1644
I P G
Sbjct: 28641 PQIEPTADLTG 28651
Score = 132 bits (331), Expect = 5e-30
Identities = 182/774 (23%), Positives = 307/774 (39%), Gaps = 82/774 (10%)
Query: 925 FSCHAINSYGEDRGLIQLTV--QEPPDPPELEIR-EVKARSMNLRWTQRFDGNSIITGFD 981
F A+N GE + L V Q+ PP +++R V+ ++ ++ + + +TG
Sbjct: 15367 FRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLP 15426
Query: 982 ---IEY-KNKS------DSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRS 1031
IE+ KN++ D+ + + S + +I + + + N++G
Sbjct: 15427 MPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLG-- 15484
Query: 1032 EPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNG--VIRGYQIGYREN 1089
S + E PP ++ + + ++S +TW AP L NG I Y I R+
Sbjct: 15485 --SVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAP---LDNGGSEITHYVIDKRD- 15538
Query: 1090 SPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLED- 1148
S + E+ T + Y + L QY V+A N+ G + ++D
Sbjct: 15539 --ASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKS-DKVVIQDP 15595
Query: 1149 --VPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGE--WGEMQN 1204
+P PP + L+ T ++SW+ PP + GY + +G W +
Sbjct: 15596 YRLPG-PPGKPKVLARTKGSMLVSWT-PPLDNGGSPITGY---WLEKREEGSPYWSRVSR 15650
Query: 1205 ITTTRERVELRGME-------KFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDV---PGPP 1254
T+ V L+G+E + Y + +A AG G S + D PGPP
Sbjct: 15651 APITK--VGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPP 15708
Query: 1255 AGIKAVPSSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQ----PAPSEYETSPEQLF 1309
+ + + SS+ + W PP K G I+ Y + G+ P + T+ E +
Sbjct: 15709 SCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCECV- 15767
Query: 1310 YRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAG---KAPAKIISFGGT--VTTPWM 1364
+ +L ++Y V AV AG S+ PA + P I G +
Sbjct: 15768 --VPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAG 15825
Query: 1365 KDVRLPCNSVGDPAPAVKWTKDSE------DSAIPVSMDGH-RLIHTNGTLLLRAVKAED 1417
+R+P G P P W D + D + D + +++ K
Sbjct: 15826 SQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSH 15885
Query: 1418 SGYYTCTATNTGGFDTIIVNLLVQVPPDQPR-LTVSKTSASSITLTW-IPGDNGGSSIRG 1475
+G Y+ TA N G T + V P P+ L VS + S L+W +P D+GG I+G
Sbjct: 15886 TGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWKMPDDDGGDRIKG 15945
Query: 1476 FVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTH 1535
+V++ + + W V +F + L Y ++ A+N G G E I+ +T
Sbjct: 15946 YVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQ-RTT 16004
Query: 1536 GREPSFSKDQHLFTHINSTHARLNLQGW----NNGGCPITAIVLE---YRPKGT--WAWQ 1586
R+P + D + I W N+GG P+T ++E + P GT AW+
Sbjct: 16005 ARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWR 16064
Query: 1587 GLRANSSGEVFLT--ELREATWYELRMRACNSAGCGNETAQFATLDYDGSTIPP 1638
E+ T +L E YE R++A N+AG +A D +PP
Sbjct: 16065 QCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPP 16118
Score = 126 bits (317), Expect = 2e-28
Identities = 154/614 (25%), Positives = 250/614 (40%), Gaps = 41/614 (6%)
Query: 1026 NKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIG 1085
N +G + + + I + P GP + + VT++ I + W+ P + I Y +
Sbjct: 26949 NAMGSASATIRVQILDKPGPPGGP---IEFKTVTAEKITLLWRPPADD-GGAKITHYIVE 27004
Query: 1086 YRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINAT 1144
RE S +S+V + + T + K +Y V+A N+ G G P S+
Sbjct: 27005 KRETS---RVVWSMVSEHL--EECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVA 27059
Query: 1145 TLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQN 1204
V PP IT + + WS P + + GY + G W ++
Sbjct: 27060 KNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDI-SGYFLEKRDKKSLG-WFKVLK 27117
Query: 1205 ITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRS--SVLYIQTKE-DVPGPPAGIKAVP 1261
T R ++ G+ + ++Y +V A AG G S S Y D PGPPA I+
Sbjct: 27118 ETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIAD 27177
Query: 1262 SSASSVVVSWLPPTKPNG-VIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQ 1320
S+ SS+ + W P G + Y + + + Y +++L G
Sbjct: 27178 STKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVN 27237
Query: 1321 YLLWVAAVTSAGRG---NSSEKVTIEPAGKAPA--KIISFGGTVTTPWMKDVRLPCNSVG 1375
Y V+AV AG+G +E V + +AP ++ +V +DV++ G
Sbjct: 27238 YYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKG 27297
Query: 1376 DPAPAVKWTKDSEDSAIPVSMDGHRLIH---TNGTLLLRAVKAEDSGYYTCTATNTGG-- 1430
P P V W KD ++ + D I ++ L + V D+G Y T N G
Sbjct: 27298 RPPPTVTWRKDEKN----LGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEP 27353
Query: 1431 -FDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPG-DNGGSSIRGFVLQYSVDNSEEW 1488
T+ V +L P +L V S ++TL W P +GGS I +V++ W
Sbjct: 27354 KSSTVSVKVL-DTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTW 27412
Query: 1489 KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLF 1548
V S SFKL L T + ++ A+N +G G E E P+ +D
Sbjct: 27413 SVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRD---L 27469
Query: 1549 THINSTHARLNLQGWN----NGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREA 1604
+ +ST + L W +GG IT V+E + KG W + + E+ +++L+E
Sbjct: 27470 SMKDSTKTSVIL-SWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQ 27528
Query: 1605 TWYELRMRACNSAG 1618
+ E R+ A N G
Sbjct: 27529 SVLEFRVFAKNEKG 27542
Score = 126 bits (317), Expect = 2e-28
Identities = 183/798 (22%), Positives = 312/798 (39%), Gaps = 85/798 (10%)
Query: 874 GERPIIIRWEKGDTVIDPDRVMRYAIA---------TKDNGDEVVSTLKLKPAD--RGDS 922
G+ III+W K ++ + + Y + T+ N D VV +LK G
Sbjct: 29252 GKEHIIIQWTKPESD-GGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCD 29310
Query: 923 VFFSCHAINSYGEDRGLIQ---LTVQEP---PDPPEL-EIREVKARSMNLRWTQ-RFDGN 974
F A+N+ G ++ +EP P PP + + S++L WT+ +DG
Sbjct: 29311 YQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGG 29370
Query: 975 SIITGFDIEYKNK-SDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSE- 1032
+ I G+ +E + K +D W + I T + + DL YS R+ + N G SE
Sbjct: 29371 TDIVGYVLEMQEKDTDQWYRVHTNATIRNT--EFTVPDLKMGQKYSFRVAAVNVKGMSEY 29428
Query: 1033 --------PSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQI 1084
P + + I E A D VT++ S + V+ + +G +
Sbjct: 29429 SESIAEIEPVERIEIPDLELADD-LKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDL 29487
Query: 1085 GYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINAT 1144
R +I++ T + +D + ++ ++A N++G S
Sbjct: 29488 ASR----------AIID--TTESYSLLIVDKVNRYDAGKYTIEAENQSG---KKSATVLV 29532
Query: 1145 TLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQN 1204
+ D P P +V+ ++ D I+W P T++G I + +
Sbjct: 29533 KVYDTPGPCP-SVKVKEVSRDSVTITWEIP---TIDGGAPVNNYIVEKR--EAAMRAFKT 29586
Query: 1205 ITT--TRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPS 1262
+TT ++ + G+ + T Y +VL G G +VP PA ++ V
Sbjct: 29587 VTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDV 29646
Query: 1263 SASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQY 1321
+ S+V ++W P G + Y + G+ + P L + + LN G+QY
Sbjct: 29647 TKSTVTLAWEKPLYDGGSRLTGYVLEACKAGT-ERWMKVVTLKPTVLEHTVTSLNEGEQY 29705
Query: 1322 LLWVAAVTSAGRGNSSEKVT---IEPAGKAPAKIISF--GGTVTTPWMKDVRLPCNSVGD 1376
L + A G E VT ++ P +S T+ P + V L G
Sbjct: 29706 LFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGR 29765
Query: 1377 PAPAVKW----TKDSEDSAIPVSMDGHRLIHTN-GTLLLRAVKAEDSGYYTCTATNTGGF 1431
P PA W +K E + V HT L +R D+G YT N G
Sbjct: 29766 PPPAASWFFAGSKLRESERVTVET------HTKVAKLTIRETTIRDTGEYTLELKNVTGT 29819
Query: 1432 DTIIVNLLVQVPPDQPR--LTVSKTSASSITLTWIPGD-NGGSSIRGFVLQYSVDNSEEW 1488
+ + +++ P P + + + A+SIT++W P + +GG+ + G+V++ + W
Sbjct: 29820 TSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQRDAHRPGW 29879
Query: 1489 KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRI--SEIIEAKTHGREPSFSKDQH 1546
V S + +FK L G Y ++AA N G G SE+IE ++ R P +
Sbjct: 29880 LPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQ 29939
Query: 1547 LFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFL----TELR 1602
+F ++GG +T ++E + W +R N T L
Sbjct: 29940 IFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRW--VRVNKVPVTMTRYRSTGLT 29997
Query: 1603 EATWYELRMRACNSAGCG 1620
E YE R+ A N+ G G
Sbjct: 29998 EGLEYEHRVTAINARGSG 30015
Score = 125 bits (315), Expect = 3e-28
Identities = 158/709 (22%), Positives = 285/709 (40%), Gaps = 75/709 (10%)
Query: 947 PPDPPEL-EIREVKARSMNLRWTQR-FDGNSIITGFDIEYKNKS-DSWDFKQSTRNISPT 1003
PP PP ++ + S++L W++ +DG + + G+ +E K + D W +
Sbjct: 25002 PPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQG- 25060
Query: 1004 INQANIVDLHPASVYSIRMYSFNKIGRSEPSK--ELTISTEEAAPDGPPMDVTLQPVTSQ 1061
Q + L + Y+ R+ + N G EP+ ++ E P +D L+ V
Sbjct: 25061 -KQFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVL 25119
Query: 1062 SIQVTWKA-------PKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLD 1114
T + P+ E++ E + G + +E+ T + +D
Sbjct: 25120 RASATLRLFVTIKGRPEPEVK-----------WEKAEGILTDRAQIEV--TSSFTMLVID 25166
Query: 1115 NLKKF--AQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWS 1172
N+ +F +Y + ++ +G ++ +N L D PS P N+ + D +SW
Sbjct: 25167 NVTRFDSGRYNLTLEN----NSGSKTAFVNVRVL-DSPSAPV-NLTIREVKKDSVTLSW- 25219
Query: 1173 EPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQ 1232
EPP + Y V N T T R+E +++ +Y +VLA +
Sbjct: 25220 EPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIE--NLQEGCSYYFRVLASNE 25277
Query: 1233 AGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IRKYTIFCSSP 1291
G G+ + + P PP + V + ++ + W P G I Y + +
Sbjct: 25278 YGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTK 25337
Query: 1292 GSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE--------KVTIE 1343
GS + + T + L I+ L G++Y+ VAAV GR + + + I+
Sbjct: 25338 GSEKWSTC---TQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIK 25394
Query: 1344 PAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDS----EDSAIPVSMDGH 1399
P+ + P T + +++ G P V W KD E + + VS
Sbjct: 25395 PSVELPFH------TFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSS-- 25446
Query: 1400 RLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR-LTVSKTSASS 1458
T +L ++ ED G Y +N+ G T+ + ++V P P + + + S S
Sbjct: 25447 ---KTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDS 25503
Query: 1459 ITLTWIPGD-NGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAA 1517
IT++W P + +GG I ++++ S W V + + S K+ L G+ Y+ ++ A
Sbjct: 25504 ITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCA 25563
Query: 1518 KNSVGSGRISE--IIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVL 1575
+N G SE + A+ P + ST N+GG + L
Sbjct: 25564 ENRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHL 25623
Query: 1576 EYRPKGTWAWQGLRAN----SSGEVFLTELREATWYELRMRACNSAGCG 1620
EY+ + + W +AN + ++ ++ L E YE R+ A N AG G
Sbjct: 25624 EYKERSSILWS--KANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIG 25670
Score = 125 bits (313), Expect = 6e-28
Identities = 158/694 (22%), Positives = 282/694 (40%), Gaps = 37/694 (5%)
Query: 943 TVQEPPDPPELEIREVKARSMNLRWTQR-FDGNSIITGFDIEYK-NKSDSWDFKQSTRNI 1000
TV +P P + + S+++ W + +DG S ITG+ +E + D W +
Sbjct: 21752 TVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGL 21811
Query: 1001 SPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTS 1060
T I L Y IR+Y+ N G EP+ L T +A P ++ L
Sbjct: 21812 KAT--SYTITGLTENQEYKIRIYAMNSEGLGEPA--LVPGTPKAEDRMLPPEIELDADLR 21867
Query: 1061 QSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFA 1120
+ + + + I+G + + +++T + + N+ +F
Sbjct: 21868 KVVTIRACCTLRLFVP--IKGRPAPEVKWARDHGESLDKASIESTSSYTLLIVGNVNRFD 21925
Query: 1121 QYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLN 1180
++ N +G+ S+ +N L D P PP++++ +T ++W +PP
Sbjct: 21926 SGKYILTVENSSGS--KSAFVNVRVL-DTPG-PPQDLKVKEVTKTSVTLTW-DPPLLDGG 21980
Query: 1181 GVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSS 1240
+K Y V N T +V+ +++ +Y +VLA + G G+ +
Sbjct: 21981 SKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQ--LQEGCSYYFRVLAENEYGIGLPAE 22038
Query: 1241 VLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPS 1299
+ P PP I + + +SV +SW P G I Y + + GS + A
Sbjct: 22039 TAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATC 22098
Query: 1300 EYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNS---SEKVTIEPAGKAPAKIISFG 1356
E I L +G++Y V+A G + S V + PA + F
Sbjct: 22099 ATVKVTEAT---ITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFN 22155
Query: 1357 GTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAE 1416
T T +D+++ +G P PAV W KD+ ++ N L ++ E
Sbjct: 22156 -TFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAEST-ENNSLLTIKDACRE 22213
Query: 1417 DSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR--LTVSKTSASSITLTWIPGD-NGGSSI 1473
D G+Y TN+ G +N++V P P + + + +A SITL+W P +GGSSI
Sbjct: 22214 DVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSI 22273
Query: 1474 RGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAK 1533
++++ ++ W+ V + + + K LK G Y+ ++AA+N G S + ++
Sbjct: 22274 NNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGK---STYLNSE 22330
Query: 1534 THGREPSFSKDQHLFTHINSTHARLNLQ-GWN----NGGCPITAIVLEYRPKGTWAWQGL 1588
+ F T + + +R +++ WN +GG + LE + + + W L
Sbjct: 22331 PTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKL 22390
Query: 1589 RANSSGEVFL--TELREATWYELRMRACNSAGCG 1620
+ T L E YE R+ A N G G
Sbjct: 22391 NKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIG 22424
Score = 124 bits (311), Expect = 1e-27
Identities = 182/811 (22%), Positives = 326/811 (40%), Gaps = 71/811 (8%)
Query: 862 KGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGD 921
+G L +G+ I +W K I R IAT + E+V +K ADRGD
Sbjct: 30150 QGGVIRLTIPIKGKPFPICKWTKEGQDISK----RAMIATSETHTELV----IKEADRGD 30201
Query: 922 SVFFSCHAINSYGEDRGLIQLTVQEPPDPPE--LEIREVKARSMNLRW-TQRFDGNSIIT 978
S + N G+ I++ V P+ PE LE +++ RS+ + W DG + I
Sbjct: 30202 SGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADIL 30261
Query: 979 GFDIEYKN--KSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKE 1036
G+ +E + K+ + R S + L Y R+ + N+ G S+P K
Sbjct: 30262 GYILERREVPKAAWYTIDSRVRGTSLVVK-----GLKENVEYHFRVSAENQFGISKPLKS 30316
Query: 1037 ---LTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGS 1093
+T T P+ P + VT S+ ++W PK + + GY I +E S
Sbjct: 30317 EEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDD-GGSRVTGYYIERKETSTDK 30375
Query: 1094 NGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAG---TGPSSSEINATTLEDVP 1150
+++ ++ T +YT+ L A+Y + A N G T P+S + D P
Sbjct: 30376 WVRHNKTQITTT----MYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKP 30431
Query: 1151 SQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRE 1210
SQP E + LSI+ D + W +P +L GY V + D W + +
Sbjct: 30432 SQPGE-LEILSISKDSVTLQWEKPECDGGKEIL-GYWVEY-RQSGDSAWKKSNKERIKDK 30488
Query: 1211 RVELRGMEKFTNYSVQVLAYTQAG-DGVRSSVLYIQTK---EDVPGPPAGIKAVPSS-AS 1265
+ + G+ + T Y +V A + G R + + I+TK + PG +K V +
Sbjct: 30489 QFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGE 30548
Query: 1266 SVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQ--QYLL 1323
+ +S +P I+ Y G +Y+ S + + + + Q + +
Sbjct: 30549 AAQLSCQIVGRPLPDIKWYRF-----GKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVY 30603
Query: 1324 WVAAVTSAGRGNSSEKVTIEPAGK----APAKIISFGGTVTTPWMKDVRLPCNSVGDPAP 1379
A G +S K+ ++ + P K +G +T +RL +G P P
Sbjct: 30604 TCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGST-----LRLHVMYIGRPVP 30658
Query: 1380 AVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLL 1439
A+ W + ++ H ++ + +G Y +N G I+++
Sbjct: 30659 AMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVE 30718
Query: 1440 VQVPPDQPR--LTVSKTSASSITLTW-IPGDNGGSSIRGFVLQ-YSVDNSEEWKDVFISS 1495
+Q PD+P + + +S ++W P D+GGS I +V++ EW+ V +
Sbjct: 30719 IQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAI 30778
Query: 1496 SERSFKLDSLKCGTWYKVKLAAKNSVGSG---RISEIIEAKTHGREPSFSKDQHLFTHIN 1552
S + ++ +L Y +++A+N+ G +S ++ K+ +P + + T +
Sbjct: 30779 SVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPG-APGKPTITAVT 30837
Query: 1553 STHARLNLQGW----NNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLT--ELREATW 1606
+ W ++GG I LE R K W + E + L E
Sbjct: 30838 KDSC---VVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLE 30894
Query: 1607 YELRMRACNSAGCGNETAQFATLDYDGSTIP 1637
YE R++ C + G +E ++ + S +P
Sbjct: 30895 YEFRVK-CENLGGESEWSEISEPITPKSDVP 30924
Score = 124 bits (310), Expect = 1e-27
Identities = 196/879 (22%), Positives = 318/879 (36%), Gaps = 99/879 (11%)
Query: 793 QQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDI---------SKSMFL 843
++ P ++ + SL++ + E + A N VG + +K L
Sbjct: 18839 EEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLL 18898
Query: 844 TVKI--PAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIAT 901
KI P IT + I+ H G+ +W+KG+ D V+ +
Sbjct: 18899 PPKILMPEQITIKAGKKLRIEAHVY-------GKPHPTCKWKKGE-----DEVVTSSHLA 18946
Query: 902 KDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPE--LEIREVK 959
D S L +K R DS ++S A NS G D I++ V + P PP+ +I ++
Sbjct: 18947 VHKADSS-SILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDID 19005
Query: 960 ARSMNLRW-TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVY 1018
A + +L W DG S IT + +E K D T S T + L P Y
Sbjct: 19006 ADACSLSWHIPLEDGGSNITNYIVE---KCDVSRGDWVTALASVTKTSCRVGKLIPGQEY 19062
Query: 1019 SIRMYSFNKIGRSEP--SKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQN 1076
R+ + N+ G SEP S ++ P P + + V I V W P + +
Sbjct: 19063 IFRVRAENRFGISEPLTSPKMVAQFPFGVP-SEPKNARVTKVNKDCIFVAWDRPDSDGGS 19121
Query: 1077 GVIRGYQIGYRENSPGSNGQYSIVEMKATGD---SEVYTLDNLKKFAQYGVVVQAFNRAG 1133
+I GY I +E + S++ +KA S Y L + +Y + A N+AG
Sbjct: 19122 PII-GYLIERKERN-------SLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAG 19173
Query: 1134 TGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSL 1193
+ P S T +P PP + +T + W+ P + ++ GY V L
Sbjct: 19174 SSPPSKPTEYVTAR-MPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKII-GYFVEACKL 19231
Query: 1194 YVDGEWGEMQNI--TTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP 1251
D +W +E G+E+ Y + +A T S P
Sbjct: 19232 PGD-KWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSE----------P 19280
Query: 1252 GPPAGIKA--VPS--SASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQ 1307
P I A VP S + S L V T+F G+P P+
Sbjct: 19281 SDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVF------GKPMPTVSWKKDGT 19334
Query: 1308 LFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDV 1367
L + Q L + S R +S + TI + +K + V
Sbjct: 19335 LLKPAEGIKMAMQRNLCTLELFSVNRKDSGD-YTITAENSSGSKSATIKLKVLDKPGPPA 19393
Query: 1368 RLPCNSVGDPAPAVKWTKDSEDSAIPVS---MDGHRLIHTN-----------GTLLLRAV 1413
+ N + + W ED ++ +D N + + +
Sbjct: 19394 SVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLI 19453
Query: 1414 KAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQP-----RLTVSKTSASSITLTW-IPGD 1467
+ + + C G D + + P P +S + +T++W P D
Sbjct: 19454 EGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPAD 19513
Query: 1468 NGGSSIRGFVLQYSVDNSEEWKDVFISS-SERSFKLDSLKCGTWYKVKLAAKNSVGSGRI 1526
+GGS I G++L+ + W V ER+ K L+ GT Y+ ++ A N G G+
Sbjct: 19514 DGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKP 19573
Query: 1527 SEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWN----NGGCPITAIVLEYR--PK 1580
S+ +A + R+P + F + T W +GG PI ++E +
Sbjct: 19574 SDASKA-AYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADS 19632
Query: 1581 GTWAWQGLRANSSGEVF-LTELREATWYELRMRACNSAG 1618
W L N F +T L E T Y+ R+ A N G
Sbjct: 19633 DNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIG 19671
Score = 124 bits (310), Expect = 1e-27
Identities = 149/609 (24%), Positives = 243/609 (39%), Gaps = 44/609 (7%)
Query: 1034 SKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGS 1093
+K +++ + GP +T+ VT + + W P+++ I Y + RE S
Sbjct: 29128 TKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQED-GGAEITHYIVERRET---S 29183
Query: 1094 NGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSE-INATTLEDVPS 1151
+ IVE + S Y + L K +Y V+A N+ G G P SE I A +PS
Sbjct: 29184 RLNWVIVEGECPTLS--YVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPS 29241
Query: 1152 QPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTR-- 1209
PP + + +I W++ P S + Y V + E +++ TR
Sbjct: 29242 -PPGIPEEVGTGKEHIIIQWTK-PESDGGNEISNYLV---------DKREKKSLRWTRVN 29290
Query: 1210 -------ERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVL-YIQTKED--VPGPPAGIKA 1259
R+++ + + +Y +V A AG+ S +I +E PGPP+ +
Sbjct: 29291 KDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRV 29350
Query: 1260 VPSSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRG 1318
V ++ S+ ++W P G I Y + + Q + + + L G
Sbjct: 29351 VDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMG 29410
Query: 1319 QQYLLWVAAVTSAGRGNSSEKVT-IEPAGKAPAKIISFGG----TVTTPWMKDVRLPCNS 1373
Q+Y VAAV G SE + IEP + + TVT +RL +
Sbjct: 29411 QKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSV 29470
Query: 1374 VGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDT 1433
G P P + W+K D A +D + L++ V D+G YT A N G +
Sbjct: 29471 SGRPPPVITWSKQGIDLASRAIID---TTESYSLLIVDKVNRYDAGKYTIEAENQSGKKS 29527
Query: 1434 IIVNLLV-QVPPDQPRLTVSKTSASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDV 1491
V + V P P + V + S S+T+TW IP +GG+ + ++++ +K V
Sbjct: 29528 ATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTV 29587
Query: 1492 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI 1551
S+ +++ L GT Y ++ +N G G E +A P +
Sbjct: 29588 TTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVT 29647
Query: 1552 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSG--EVFLTELREATWYEL 1609
ST + +GG +T VLE GT W + E +T L E Y
Sbjct: 29648 KSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLF 29707
Query: 1610 RMRACNSAG 1618
R+RA N G
Sbjct: 29708 RIRAQNEKG 29716
Score = 123 bits (308), Expect = 2e-27
Identities = 169/723 (23%), Positives = 285/723 (39%), Gaps = 94/723 (13%)
Query: 946 EPPDPP-ELEIREVKARSMNLRWTQR-FDGNSIITGFDIEYKNK----SDSWDFKQSTRN 999
EPP PP + + S+ L W + +DG + I G+ +E + K S +K+
Sbjct: 18495 EPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAA 18554
Query: 1000 ISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPS--KELTISTEEAAPDGPPMDVTLQ- 1056
+ + L Y R+ + N++G P+ KE E P +D +++
Sbjct: 18555 AQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRK 18614
Query: 1057 --------PVTSQSI-------QVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVE 1101
P+ +I +VTW+ K + N V+R Q+ + + ++
Sbjct: 18615 LVIVRAGCPIRLFAIVRGRPAPKVTWR--KVGIDN-VVRKGQVDLVDTMA-----FLVIP 18666
Query: 1102 MKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSS----SEINATTLEDVPSQPPENV 1157
DS Y+L + + V V GP S S++ T+ V PPEN
Sbjct: 18667 NSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCH-VSWAPPEND 18725
Query: 1158 RALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGM 1217
+T ++ E R T WS + + +
Sbjct: 18726 GGSQVTH--YIVEKREADRKT------------WSTVTP---------EVKKTSFHVTNL 18762
Query: 1218 EKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDV---PGPPAGIKAVPSSASSVVVSWLPP 1274
Y +V A + G GV + V D P PP ++ + +S ++WLPP
Sbjct: 18763 VPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPP 18822
Query: 1275 TKPNGV-IRKYTIFCSSPGSGQPAPSEYETSP-EQLFYRIAHLNRGQQYLLWVAAVTSAG 1332
+ G I Y S QPA E S + L + L G++Y VAA + G
Sbjct: 18823 LRDGGAKIDGY--ITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVG 18880
Query: 1333 RGNSSEKVTIEPAGKA--PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDS 1390
E + A + P KI+ +T K +R+ + G P P KW K ++
Sbjct: 18881 VSLPREAEGVYEAKEQLLPPKIL-MPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDE- 18938
Query: 1391 AIPVSMDGHRLIH---TNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQ--VPPD 1445
V H +H ++ L+++ V +DSGYY+ TA N+ G DT + ++V P
Sbjct: 18939 ---VVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPP 18995
Query: 1446 QPRLTVSKTSASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDS 1504
QP +S A + +L+W IP ++GGS+I ++++ + +W S ++ S ++
Sbjct: 18996 QPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGK 19055
Query: 1505 LKCGTWYKVKLAAKNSVGSGRISE-IIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGW 1563
L G Y ++ A+N G ISE + K + P + + + W
Sbjct: 19056 LIPGQEYIFRVRAENRFG---ISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAW 19112
Query: 1564 ----NNGGCPITAIVLEYRPKGTWAWQGLRANS----SGEVFLTELREATWYELRMRACN 1615
++GG PI ++E + + + W ++AN S E L E Y R+ A N
Sbjct: 19113 DRPDSDGGSPIIGYLIERKERNSLLW--VKANDTLVRSTEYPCAGLVEGLEYSFRIYALN 19170
Query: 1616 SAG 1618
AG
Sbjct: 19171 KAG 19173
Score = 122 bits (307), Expect = 3e-27
Identities = 150/629 (23%), Positives = 250/629 (39%), Gaps = 48/629 (7%)
Query: 1048 GPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGD 1107
GPP++ + + S+ W+ P + + +I + P S + + +T
Sbjct: 14803 GPPINFVFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEW----IVVTSTLR 14858
Query: 1108 SEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDV-PSQPPENVRALSITSDV 1166
Y++ L + +Y V+A NR G GP + P P+ +TS+
Sbjct: 14859 HCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNS 14918
Query: 1167 AVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQ 1226
++ W+EP + + GY + + W + + + G+ + Y +
Sbjct: 14919 MLVKWNEPKDN--GSPILGYWLEKREVN-STHWSRVNKSLLNALKANVDGLLEGLTYVFR 14975
Query: 1227 VLAYTQAGDGVRSSVLYIQTKEDV---PGPPAGIKAVPSSASSVVVSWLPPT-KPNGVIR 1282
V A AG G S +T D PGPP + +S++++ + W PP G I
Sbjct: 14976 VCAENAAGPGKFSPPSDPKTAHDPISPPGPPIP-RVTDTSSTTIELEWEPPAFNGGGEIV 15034
Query: 1283 KYTIFCSSPGSGQPAPSEYETSPEQLF----YRIAHLNRGQQYLLWVAAVTSAGRG--NS 1336
Y + G+ +E+ E++ Y + + G Y L V+AV +AG G
Sbjct: 15035 GYFVDKQLVGT-----NEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGE 15089
Query: 1337 SEKVTIEPAGKAPAKI--ISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPV 1394
++ VT+ + PA +S G + K +R+P G P P WTK+ +
Sbjct: 15090 TQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGE----- 15144
Query: 1395 SMDGHRLIHTN-GT---LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV-QVPPDQPRL 1449
+D R++ N GT L+++ +D G Y TATN+ G + V VP L
Sbjct: 15145 -LDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPGPVLDL 15203
Query: 1450 TVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCG 1508
T+ L W P D+GGS I GF+++ W+ I + + L G
Sbjct: 15204 KPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQP-IETERSKCDITGLLEG 15262
Query: 1509 TWYKVKLAAKNSVGSG---RISEIIEAKTHGREPSFSKDQHLFTHINSTHARLN-LQGWN 1564
YK ++ AKN G G I I+ G P S ++ +T + L+ + +
Sbjct: 15263 QEYKFRVIAKNKFGCGPPVEIGPILAVDPLG--PPTSPERLTYTERTKSTITLDWKEPRS 15320
Query: 1565 NGGCPITAIVLEYR--PKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCGNE 1622
NGG PI ++E R K + R + + L E YE R++A N G
Sbjct: 15321 NGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEP 15380
Query: 1623 TAQFATLDYDGSTIPPIK-SAQGEGDDVK 1650
+ + D P IK GD +K
Sbjct: 15381 SLPLNVVIQDDEVPPTIKLRLSVRGDTIK 15409
Score = 122 bits (306), Expect = 4e-27
Identities = 173/777 (22%), Positives = 307/777 (39%), Gaps = 78/777 (10%)
Query: 881 RWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLI 940
RW++ + DP + M ++ K G G F +AIN+ G +
Sbjct: 16362 RWKRVNR--DPIKAMTLGVSYKVTG-----------LIEGSDYQFRVYAINAAGVGPASL 16408
Query: 941 Q---LTVQEP---PDPPELEIREVKARSMNLRWTQRF-DGNSIITGFDIEYKNKS-DSWD 992
T ++P P PP ++ + S +L W+ DG S +TG+ +EYK + + W+
Sbjct: 16409 PSDPATARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWE 16468
Query: 993 FKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMD 1052
K + + T + + L + Y R+ + N G EP + + + P D
Sbjct: 16469 -KGKDKEVRGT--KLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSP--D 16523
Query: 1053 VTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVE--------MKA 1104
+ L I V GVIR I Y P +++ E ++
Sbjct: 16524 LQLDASVRDRIVVH--------AGGVIR--IIAYVSGKPPPTVTWNMNERTLPQEATIET 16573
Query: 1105 TGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITS 1164
T S + N ++ Q + A N AG + ++ DVP A ++T+
Sbjct: 16574 TAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVL---DVPGPVGTPFLAHNLTN 16630
Query: 1165 DVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYS 1224
+ ++W P + + + D T TR+ ++G+ + Y
Sbjct: 16631 ESCKLTWFSPEDDGGSPITN---YVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYF 16687
Query: 1225 VQVLAYTQAGDGV---RSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV- 1280
++ A G G S L I+ VP P ++ + ++V ++W PP G
Sbjct: 16688 FRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSE 16747
Query: 1281 IRKYTIFCSSPGSGQPAPSEYETSPEQLF---YRIAHLNRGQQYLLWVAAVTSAGRGNSS 1337
I Y + G+ + ++ + + L Y + L G Y V+AV G+G S
Sbjct: 16748 IINYVLESRLIGTEK----FHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPS 16803
Query: 1338 ---EKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPV 1394
+ +T + P + F +T + L G P P V W KD D +
Sbjct: 16804 FCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADV---L 16860
Query: 1395 SMDGHRLIHTNGTLLLRAVKAE--DSGYYTCTATNTGGFDTII--VNLLVQVPPDQPRLT 1450
D + T TL L +KA+ DSG Y N+ G VN++ + P ++
Sbjct: 16861 EDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVS 16920
Query: 1451 VSKTSASSITLTWIPG-DNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGT 1509
+ + + ++W P D+GGS I ++++ + W V +S++ + K+ L G
Sbjct: 16921 FDEVTKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGK 16980
Query: 1510 WYKVKLAAKN--SVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGG 1567
Y ++ A+N + +S+ ++AK R P + DQ + T + A + ++GG
Sbjct: 16981 DYIFRIHAENLYGISDPLVSDSMKAKDRFRVPD-APDQPIVTEVTKDSALVTWNKPHDGG 17039
Query: 1568 CPITAIVLEYRPKGTWAWQGLR---ANSSGEVFLTELREATWYELRMRACNSAGCGN 1621
PIT +LE R + W + + + + +L E YE R+ A N G G+
Sbjct: 17040 KPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGD 17096
Score = 122 bits (306), Expect = 4e-27
Identities = 228/1015 (22%), Positives = 393/1015 (38%), Gaps = 165/1015 (16%)
Query: 688 ITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVR 747
I W K Q + + + + I+S +F +SL + +GNY A N A ER + V
Sbjct: 22575 IQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAG----ERSVTVN 22630
Query: 748 V-------PPRFVV--------------QPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHA 786
V PP V +P QDG + ++N V+ +++W
Sbjct: 22631 VKVLDRPGPPEGPVVISGVTAEKCTLAWKPPLQDG---GSDIINYIVERRETSRLVW--- 22684
Query: 787 KGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN--GVGTDISKSMFLT 844
+ +Q L S + +LE + + A N GVG + +S +
Sbjct: 22685 -----------TVVDANVQTL---SCKVTKLLEGNEYTFRIMAVNKYGVGEPL-ESEPVV 22729
Query: 845 VKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDN 904
K P ++ P A E+ + +I+ WE+ + ++ Y + +D
Sbjct: 22730 AKNPFVVPDAPK--------APEVTTVTKDS--MIVVWERPASD-GGSEILGYVLEKRDK 22778
Query: 905 GD--------EVVSTLKLKPAD--RGDSVFFSCHAINSYGEDRGLIQLTVQE-------P 947
++ L+L+ F A N+ G Q+ P
Sbjct: 22779 EGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKP 22838
Query: 948 PDPPELEIREVKARSMNLRWTQR-FDGNSIITGFDIEYKNKS-DSWDFKQSTRNISPT-I 1004
P ++ ++ S+ L W++ +DG I G+ +E + S W I+ T I
Sbjct: 22839 GPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNI 22898
Query: 1005 NQANIVDLHPASVYSIRMYSFNKIGRSEPSK---ELTISTEEAAPDGPPMDVTLQPVT-- 1059
+++ H Y+ R+ + NK G E + + + + APD +D+ L+ +
Sbjct: 22899 EVEKLLEKHE---YNFRICAINKAGVGEHADVPGPIIVEEKLEAPD-IDLDLELRKIINI 22954
Query: 1060 ----SQSIQVTWKA-PKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLD 1114
S + V K P E++ G + G +I+++ ++ S V LD
Sbjct: 22955 RAGGSLRLFVPIKGRPTPEVKWGKV-----------DGEIRDAAIIDVTSSFTSLV--LD 23001
Query: 1115 NLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEP 1174
N+ ++ + N +GT S + D PS PP N++ IT D I+W EP
Sbjct: 23002 NVNRYDSGKYTLTLENSSGT---KSAFVTVRVLDTPS-PPVNLKVTEITKDSVSITW-EP 23056
Query: 1175 PRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAG 1234
P +K Y V + N +++ +++ +Y +V A + G
Sbjct: 23057 PLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQ--LQEGCSYYFRVTAENEYG 23114
Query: 1235 DGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGS 1293
G+ + +VP PP I + +SV +SW P G I +Y + + S
Sbjct: 23115 IGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHS 23174
Query: 1294 GQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNS--------SEKVTIEPA 1345
+ + S + + I +L +G++YL V AV GR + ++ + IEP
Sbjct: 23175 EKWSECARVKSLQAV---ITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPD 23231
Query: 1346 GKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTN 1405
K PA S+ V +D+++ G P P + WTKD +P+ R+ T+
Sbjct: 23232 VK-PA-FSSYSVQVG----QDLKIEVPISGRPKPTITWTKDG----LPLKQTT-RINVTD 23280
Query: 1406 G----TLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR--LTVSKTSASSI 1459
TL ++ +D G Y T N G T + ++ PD P+ + SA SI
Sbjct: 23281 SLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESI 23340
Query: 1460 TLTWIPG-DNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAK 1518
TL+W P GG I +++Q + W V + + + K+ LK GT Y+ ++ A+
Sbjct: 23341 TLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAE 23400
Query: 1519 NSVGSGRI--SEIIEAKTHGREP---------SFSKDQHLFTHINSTHARLNLQGWNNGG 1567
N G S+ I A+ +EP + SKD + NNGG
Sbjct: 23401 NRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPV---------NNGG 23451
Query: 1568 CPITAIVLEYRPKGTWAWQGLRAN--SSGEVFLTELREATWYELRMRACNSAGCG 1620
P+ LE + + + W + + L E YE R+ A N G G
Sbjct: 23452 SPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVG 23506
Score = 121 bits (304), Expect = 6e-27
Identities = 230/1034 (22%), Positives = 385/1034 (37%), Gaps = 167/1034 (16%)
Query: 670 GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTC 729
G++L I ++ +P+ I+W KDG I + I S + + L + + G Y
Sbjct: 25804 GEVLKINADIAGRPLPV-ISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVL 25862
Query: 730 IASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGS 789
N A T S V P P +G+ + CS+ W
Sbjct: 25863 TLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAE----KCSLS--------W------ 25904
Query: 790 GNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN-----------------G 832
G PQ+ + I +S L + E ++ C+ + G
Sbjct: 25905 GRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYG 25964
Query: 833 VGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELN--CTARGERP--------IIIRW 882
VG + +S+ + P + S P T++ I KE C +R E II R
Sbjct: 25965 VGEPL-ESVAIKALDPFTVPSPP-TSLEITSVTKESMTLCWSRPESDGGSEISGYIIERR 26022
Query: 883 EKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPAD--RGDSVFFSCHAINSYG-----E 935
EK +R+ K + V L++K G + +A N+ G E
Sbjct: 26023 EKNS--------LRWVRVNK----KPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSE 26070
Query: 936 DRGLIQLT--VQEPPDPPELEIREVKARSMNLRWTQR-FDGNSIITGFDIEYKNKSDSWD 992
LI+ V P P + +I + ++ + W + FDG + ITG+ +EYK KSD D
Sbjct: 26071 TSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYK-KSDDTD 26129
Query: 993 FKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMD 1052
+K S +++ T + I L + Y R+ S NK+G S+PS + + P D
Sbjct: 26130 WKTSIQSLRGT--EYTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFD 26187
Query: 1053 VTLQ-----------------PVTSQSI-QVTWKAPKKELQNGVIRGYQIGYRENSPGSN 1094
+ + P + + V W P +L+ R ++
Sbjct: 26188 IDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRT----------RAYVDTTD 26237
Query: 1095 GQYSI-VEMKATGDSEVYTL--DNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPS 1151
+ S+ +E DS YTL N+ A +VV+ + G
Sbjct: 26238 SRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPG------------------ 26279
Query: 1152 QPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRER 1211
PP N+ +T + AV+SW + P + +K Y + W + N R
Sbjct: 26280 -PPTNITVQDVTKESAVLSW-DVPENDGGAPVKNYHIEKREASKKA-WVSVTN-NCNRLS 26335
Query: 1212 VELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDV-----PGPPAGIKAVPSSASS 1266
++ +++ Y +V + G G+ + +TKE V P PP + S S
Sbjct: 26336 YKVTNLQEGAIYYFRVSGENEFGVGIPA-----ETKEGVKITEKPSPPEKLGVTSISKDS 26390
Query: 1267 VVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWV 1325
V ++WL P G I Y + G S + ++ L +Y V
Sbjct: 26391 VSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHV---VSGLRENSEYFFRV 26447
Query: 1326 AAVTSAGRGNSSE-------KVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPA 1378
A AG + E K +EP S V V +P + G P
Sbjct: 26448 FAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPIS--GKPL 26505
Query: 1379 PAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNL 1438
P V ++D + + + N T+ L+ D+G Y TA N+ G +N+
Sbjct: 26506 PKVTLSRDGVPLKATMRFNTE-ITAENLTINLKESVTADAGRYEITAANSSGTTKAFINI 26564
Query: 1439 LVQVPPDQPR--LTVSKTSASSITLTWIPGD-NGGSSIRGFVLQYSVDNSEEWKDVFISS 1495
+V P P + +S + S+TL W P +GGS + ++L ++ W +V +
Sbjct: 26565 VVLDRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATV 26624
Query: 1496 SERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIE-AKTHGREPSFSKDQHLFTHINST 1554
+ K+ L G Y+ ++ A+N G IS+ I+ A + P + + +
Sbjct: 26625 ARTMMKVMKLTTGEEYQFRIKAENRFG---ISDHIDSACVTVKLPYTTPGPPSTPWVTNV 26681
Query: 1555 HARLNLQGW----NNGGCPITAIVLEYRPKGTWAWQGLRANS----SGEVFLTELREATW 1606
GW +NGG + LE + + + WQ +AN + +T +
Sbjct: 26682 TRESITVGWHEPVSNGGSAVVGYHLEMKDRNSILWQ--KANKLVIRTTHFKVTTISAGLI 26739
Query: 1607 YELRMRACNSAGCG 1620
YE R+ A N+AG G
Sbjct: 26740 YEFRVYAENAAGVG 26753
Score = 119 bits (299), Expect = 2e-26
Identities = 230/1045 (22%), Positives = 400/1045 (38%), Gaps = 147/1045 (14%)
Query: 670 GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMS------SLQISSVSLKH 723
G+ ++IP V+ MP +I W K+ VI + +KE +S L I +
Sbjct: 15413 GEPVHIPADVTGLPMP-KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVRED 15471
Query: 724 NGNYTCIASNAAATVSRERQLIVR---VPPR-FVVQPNNQDGIY---------GKAGVLN 770
G YT ASN +V R + V PPR V + Y G + + +
Sbjct: 15472 KGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGGSEITH 15531
Query: 771 CSVDGYPPP--KVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQ 828
+D K W+ + ++Y G +++PN R +
Sbjct: 15532 YVIDKRDASRKKAEWEEVTNTAVEKRY------GIWKLIPNGQYEFR-----------VR 15574
Query: 829 ASNGVG-TDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKG-D 886
A N G +D KS + ++ P + P G K L AR + +++ W D
Sbjct: 15575 AVNKYGISDECKSDKVVIQDPYRLPGPP-------GKPKVL---ARTKGSMLVSWTPPLD 15624
Query: 887 TVIDPDRVMRYAIATKDNGDEVVSTLKLKPADR---------------GDSVFFSCHAIN 931
P + Y + ++ G S + P + G F AIN
Sbjct: 15625 NGGSP--ITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAIN 15682
Query: 932 SYG-------EDRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRF-DGNSIITGFDIE 983
+ G D + + P P E+++ S++L W DG S I G+ +E
Sbjct: 15683 AAGIGPPSEPSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVE 15742
Query: 984 YKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEE 1043
+ + + + + + T + + +L Y R+ + N+ G SEPS +
Sbjct: 15743 MQEEGTTDWKRVNEPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESEPS--------D 15794
Query: 1044 AAPDGPPMDVTLQPVTSQSIQ----VTWKAPKKELQNGVIRG-------YQIGYRENSPG 1092
+ P D+ +P I + KA + VI+G ++ +
Sbjct: 15795 TTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAM 15854
Query: 1093 SNGQYSIVE---MKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDV 1149
+G + I E ++ +S V + K+ + A N+AG ++ + DV
Sbjct: 15855 KDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVM---DV 15911
Query: 1150 PSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTR 1209
P PP++++ IT +SW P + + KGY + +DG+ N
Sbjct: 15912 PG-PPKDLKVSDITRGSCRLSWKMPDDDGGDRI-KGY--VIEKRTIDGKAWTKVNPDCGS 15967
Query: 1210 ERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDV---PGPPAGIKAVPSSASS 1266
+ + Y +V A + G G + T D P PP +K + ++
Sbjct: 15968 TTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNT 16027
Query: 1267 VVVSWLPPTKPNGV-IRKYTIFCSS---PGSGQPAPSEY-ETSPEQLFYRIAHLNRGQQY 1321
V +SW PP G + Y + C + G+ + A + + E+L + + L G +Y
Sbjct: 16028 VHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEY 16087
Query: 1322 LLWVAAVTSAGRGNSSEKVTIEPAGKAPAKI---ISFGGTVTTPWMKDVRLPCNSVGDPA 1378
V AV +AG S T+ P + I + +V + G P
Sbjct: 16088 EFRVKAVNAAGVSKPS--ATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPF 16145
Query: 1379 PAVKWTK---DSEDSAIPVSMDGH---RLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFD 1432
P + W K D+ PV D H ++ TL++ + D+G YT TA N G
Sbjct: 16146 PTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTA 16205
Query: 1433 T--IIVNLLVQVPPDQPRLTVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVDNSEEWK 1489
+ + +N+L + P + SA +TL+W P D+GGS I +V++ N + W
Sbjct: 16206 SKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWV 16265
Query: 1490 DVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFS----KDQ 1545
V E ++ + L G Y ++ A+N G I E ++++ FS D+
Sbjct: 16266 HVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYG---IGEPLDSEPETARNLFSVPGAPDK 16322
Query: 1546 HLFTHINSTHARLNLQGWN----NGGCPITAIVLEYRPKGTWAWQ-----GLRANSSGEV 1596
+ + +N W +GG P+T LE + + W+ ++A + G
Sbjct: 16323 PTVSSVTRNSMTVN---WEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTLGVS 16379
Query: 1597 F-LTELREATWYELRMRACNSAGCG 1620
+ +T L E + Y+ R+ A N+AG G
Sbjct: 16380 YKVTGLIEGSDYQFRVYAINAAGVG 16404
Score = 119 bits (298), Expect = 3e-26
Identities = 169/713 (23%), Positives = 286/713 (40%), Gaps = 62/713 (8%)
Query: 942 LTVQEPPDPP----ELEIREVKARSMNLRWTQ-RFDGNSIITGFDIEY-KNKSDSWDFKQ 995
+ +++P DPP + +++V S+ L WT+ DG + I + IE K +D W +
Sbjct: 13975 ILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEW--VR 14032
Query: 996 STRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSK--ELTISTEEAAPDGPPMDV 1053
+ T Q + L YS R+ + NK G SEPS+ + + E+ P PP +
Sbjct: 14033 VAEGVPTT--QHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWL 14090
Query: 1054 TLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTL 1113
+ +T + + W P+K+ I Y + R+ G ++ T T+
Sbjct: 14091 EVINITKNTADLKWTVPEKD-GGSPITNYIVEKRDVR--RKGWQTV---DTTVKDTKCTV 14144
Query: 1114 DNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQP--PENVRALSITSDVAVISW 1171
L + + Y V A N G + ++ +D + P P + + +T + W
Sbjct: 14145 TPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKW 14204
Query: 1172 SEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYT 1231
EPP++ ++ Y VI + W + + + + T QV A
Sbjct: 14205 -EPPKNDGGRPIQRY-VIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAEN 14262
Query: 1232 QAGDGVRSS---VLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNG--VIRKYTI 1286
+AG G S +L I+ P PP + + + ++W PP K G +I +
Sbjct: 14263 EAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVE 14322
Query: 1287 FCSSPGSGQPAPSEYETSP-EQLFYRIAH-LNRGQQYLLWVAAVTSAGRGNSSE----KV 1340
C G + P + L +++ + ++Y+L V AV + G SE V
Sbjct: 14323 MCPV---GTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVV 14379
Query: 1341 TIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSED---SAIPVSMD 1397
+P K + + V + +P +V P P V W KD ++ S +
Sbjct: 14380 AKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAV--PVPTVSWHKDGKEVKASDRLTMKN 14437
Query: 1398 GHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNL-LVQVPPDQPRLTVSKTSA 1456
H H +RA D+G YT T N G T +N+ ++ +P + S +
Sbjct: 14438 DHISAHLEVPKSVRA----DAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITK 14493
Query: 1457 SSITLTWIPGD-NGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKL 1515
SS LTW P + +GG+ I +VL+ + V ++ S+ + L Y ++
Sbjct: 14494 SSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRV 14553
Query: 1516 AAKNSVGSGRISEIIEAKTH--GREPSFSKDQHLFTHINSTHARLNLQGWN----NGGCP 1569
A N VG G E IE K ++P D + +++ A W +GG
Sbjct: 14554 KAVNKVGGG---EYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSK 14610
Query: 1570 ITAIVLEYRPKGTWAWQGLRANSSGEVFLT----ELREATWYELRMRACNSAG 1618
I ++E KG W+ R N LT L E Y+ R+RA N+AG
Sbjct: 14611 IMGYIIEKIAKGEERWK--RCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAG 14661
Score = 119 bits (298), Expect = 3e-26
Identities = 164/717 (22%), Positives = 286/717 (39%), Gaps = 87/717 (12%)
Query: 946 EPPDPP-ELEIREVKARSMNLRWTQR-FDGNSIITGFDIEYKN-KSDSWDFKQSTRNISP 1002
+PP PP ++ I + S+ L W++ +DG S +TG+ +E + + + W + +
Sbjct: 27165 DPPGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRT 27224
Query: 1003 TINQANIVDLHPASVYSIRMYSFNKIGRSEPSK------------------ELTISTEEA 1044
T + + +L P Y R+ + N G+ EP + ++ + T
Sbjct: 27225 T--EYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVI 27282
Query: 1045 APDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKA 1104
A G + V + VTW+ +K L GS+ +YSI +
Sbjct: 27283 AKAGEDVQVLIPFKGRPPPTVTWRKDEKNL-----------------GSDARYSI---EN 27322
Query: 1105 TGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITS 1164
T S + T+ + + ++ N G P SS ++ L D P+ + ++ ++
Sbjct: 27323 TDSSSLLTIPQVTRNDTGKYILTIENGVGE-PKSSTVSVKVL-DTPAAC-QKLQVKHVSR 27379
Query: 1165 DVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYS 1224
+ W +PP + Y VI W + + ++ +L + + T +
Sbjct: 27380 GTVTLLW-DPPLIDGGSPIINY-VIEKRDATKRTWSVVSHKCSSTS-FKLIDLSEKTPFF 27436
Query: 1225 VQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNG-VIRK 1283
+VLA + G G +VP P + S+ +SV++SW P G VI +
Sbjct: 27437 FRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFDGGSVITE 27496
Query: 1284 YTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIE 1343
Y + G G+ S S + ++ L V A G S+ VTI
Sbjct: 27497 YVV--ERKGKGEQTWSHAGIS-KTCEIEVSQLKEQSVLEFRVFAKNEKGL---SDPVTIG 27550
Query: 1344 PAGKAPAKIISF-------GGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDS----EDSAI 1392
P I G VT +V L G P P++ W KD E +
Sbjct: 27551 PITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFV 27610
Query: 1393 PVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR--LT 1450
S +++ TL ++ K E G YT N + + ++ PP +P+ +
Sbjct: 27611 RFSKTENKI-----TLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKGPIR 27665
Query: 1451 VSKTSASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGT 1509
+ A S+ L+W +P DNGG I + ++ + WK V S + +FK+ +L
Sbjct: 27666 FDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDA 27725
Query: 1510 WYKVKLAAKNSVGSGR--ISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWN--- 1564
Y+ ++ A+N G + +S II AK R P ++ N T ++L W+
Sbjct: 27726 EYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIY---NVTSDGMSLT-WDAPV 27781
Query: 1565 -NGGCPITAIVLEYRPKGTWAWQGLRAN--SSGEVFLTELREATWYELRMRACNSAG 1618
+GG +T +E + + + WQ + + S E T L E Y+ R+ A NSAG
Sbjct: 27782 YDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAG 27838
Score = 117 bits (294), Expect = 9e-26
Identities = 151/617 (24%), Positives = 241/617 (39%), Gaps = 52/617 (8%)
Query: 1031 SEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENS 1090
S SK TI + GPP V + + S ++W+ P ++ I Y + RE S
Sbjct: 19373 SSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLED-GGSEITNYIVDKRETS 19431
Query: 1091 PGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVP 1150
+ Q S AT +++ L + +Y + A N+ G G + P
Sbjct: 19432 RPNWAQVS-----ATVPITSCSVEKLIEGHEYQFRICAENKYGVG--DPVFTEPAIAKNP 19484
Query: 1151 SQPPENVRA---LSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITT 1207
PP +IT D +SW +PP + GY + W ++
Sbjct: 19485 YDPPGRCDPPVISNITKDHMTVSW-KPPADDGGSPITGYLLEKRETQAVN-WTKVNRKPI 19542
Query: 1208 TRERVELRGMEKFTNYSVQVLAYTQAGDGV---RSSVLYIQTKEDVPGPPAGIKAVPSSA 1264
++ G+++ T Y +V A +AG G S Y + + PGPPA K ++
Sbjct: 19543 IERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTR 19602
Query: 1265 SSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLL 1323
SSV +SW P G I Y + S + ++ + + L QY
Sbjct: 19603 SSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQF 19662
Query: 1324 WVAAVTSAGRGNSSE--------KVTIEPAGKAPA---KIISFGGTVTTPWMKDVRLPCN 1372
V AV G + S+ + I P G+ A K + VT +RL
Sbjct: 19663 RVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVT------MRLYVP 19716
Query: 1373 SVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRA--VKAEDSGYYTCTATNTGG 1430
G P P + W+K + + + +D + T+ LR V D+G Y T N+ G
Sbjct: 19717 VKGRPPPKITWSKPNVNLRDRIGLD---IKSTDFDTFLRCENVNKYDAGKYILTLENSCG 19773
Query: 1431 FD--TIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGD-NGGSSIRGFVLQYSVDNSEE 1487
TI+V +L P +TV + S S +TW P +GGS I +V+Q +
Sbjct: 19774 KKEYTIVVKVL-DTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKS 19832
Query: 1488 WKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHL 1547
W V S+ SF++ +L+ G Y ++ A+N G G E +A + P D
Sbjct: 19833 WSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVD--- 19889
Query: 1548 FTHINSTHARLNLQGW----NNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELRE 1603
+ S GW ++GG I V+++ + WQ + + S + +L E
Sbjct: 19890 -LKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEEN-KWQRVMKSLSLQYSAKDLTE 19947
Query: 1604 ATWYELRMRACNSAGCG 1620
Y R+ A N G G
Sbjct: 19948 GKEYTFRVSAENENGEG 19964
Score = 117 bits (293), Expect = 1e-25
Identities = 175/756 (23%), Positives = 289/756 (38%), Gaps = 85/756 (11%)
Query: 833 VGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPD 892
V T + +FL VK+ A +T T I EL T G+ I W K D ++ D
Sbjct: 13682 VDTQEAPEIFLDVKLLAGLTVKAGTKI-------ELPATVTGKPEPKITWTKADMILKQD 13734
Query: 893 RVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP- 951
+ + K ST+ + + R D+ + A+N G ++++ V + P PP
Sbjct: 13735 KRITIENVPKK------STVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPA 13788
Query: 952 ELEIREVKARSMNLRWT-QRFDGNSIITGFDIEYK-NKSDSWDFKQSTRNISPTINQANI 1009
+I +V S L W R DG S IT + +E + S+ W +S T+ N
Sbjct: 13789 AFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVW------HKLSSTVKDTNF 13842
Query: 1010 --VDLHPASVYSIRMYSFNKIGRSEPSKELTISTE-EAAPDGPPMDVTLQPVTSQSIQVT 1066
L P Y R+ + N G EP + I+ + + P GPP + +T ++ +T
Sbjct: 13843 KATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLT 13902
Query: 1067 WKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVV 1126
W P + I GY + + + + + +K T Y + L +Y V
Sbjct: 13903 WCEPDDD-GGSPITGYWVERLDPDTDKWVRCNKMPVKDT----TYRVKGLTNKKKYRFRV 13957
Query: 1127 QAFNRAGTGPSSSEINATTLEDV--PSQPPENVRALSITSDVAVISWSEPPRSTLNGVLK 1184
A N AG G S ++D P PP + ++W++P ++
Sbjct: 13958 LAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDG-GAKIE 14016
Query: 1185 GYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGD---GVRSSV 1241
Y + D EW + T + + L G+ + YS +V A +AG+ S
Sbjct: 14017 SYVIEMLKTGTD-EWVRVAEGVPTTQHL-LPGLMEGQEYSFRVRAVNKAGESEPSEPSDP 14074
Query: 1242 LYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNG-VIRKYTIFCSSPGSGQPAPSE 1300
+ + K P PP ++ + + ++ + W P K G I Y + +
Sbjct: 14075 VLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIV--EKRDVRRKGWQT 14132
Query: 1301 YETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVT 1360
+T+ + + L G Y+ VAA + G+ + +E IE + A T T
Sbjct: 14133 VDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTE---IEDSVLAK-------DTFT 14182
Query: 1361 TPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGY 1420
TP L V +KW D P+ +I L R VKA +
Sbjct: 14183 TPG-PPYALAVVDVTKRHVDLKWEPPKNDGGRPIQ---RYVIEKKERLGTRWVKAGKTAG 14238
Query: 1421 YTCT-----------------ATNTGGF-----DTIIVNLLVQVPPDQPRLTVSKTSA-- 1456
C A N G T I+++ P P L + T A
Sbjct: 14239 PDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGR 14298
Query: 1457 SSITLTWIPGD-NGGSSIRGFVLQYSVDNSEEWKDVFISS-SERSFKL-DSLKCGTWYKV 1513
I + W P + NGGS I G+ ++ +E+W V + FK+ + + Y +
Sbjct: 14299 KHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVL 14358
Query: 1514 KLAAKNSVGSGRISEIIE---AKTHGREPSFSKDQH 1546
++ A N++G SEI E AK +P+ + H
Sbjct: 14359 RVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETH 14394
Score = 117 bits (293), Expect = 1e-25
Identities = 309/1434 (21%), Positives = 528/1434 (36%), Gaps = 204/1434 (14%)
Query: 300 GHTVELPCTASGYPIPAIRWLKDGRPLPAD-----SRWTKRITGLTISDLRTEDSGTYIC 354
GH V L G P P+I WLKDG PL S+ +IT L+I + + E G Y
Sbjct: 27578 GHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKIT-LSIKNAKKEHGGKYTV 27636
Query: 355 EVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCAL---TGSPEFTIRWYRN 411
+ N ++ + P P + +VILS + G E T
Sbjct: 27637 ILDNAVCRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEK 27696
Query: 412 TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIV 471
E + + ++ T + + K ++ A + +Q + IV
Sbjct: 27697 RETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLV-------SSIIV 27749
Query: 472 SSFSEKVVNP-GEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYT-MSDGTTISH 529
+ ++ P G+ + G ++TW D P+ GS T + + +I
Sbjct: 27750 AKHQFRIPGPPGKPVIYNVTSDGM---SLTW---DAPVYDGGSEVTGFHVEKKERNSILW 27803
Query: 530 MNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVI 589
V I G YR T LV +YQ R+ + + + + TL V
Sbjct: 27804 QKVNTSPI-SGREYRATG--LVEGLDYQFRVYAENSAGLSSPSD----PSKFTLAVSPVD 27856
Query: 590 --GYPYY--------SIKWYKDALLLPDNHRQVVFENGTLK----------LTDVQK--- 626
G P Y ++KW L D ++V + + TDV +
Sbjct: 27857 PPGTPDYIDVTRETITLKWNPP---LRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQY 27913
Query: 627 ---GMDEGE-YLCSVLIQPQLSI----SQSVHVAV----KVPPLIQ--PFEFPPASI--G 670
G+ G+ Y ++ + + SQS + + VPP+++ P F I G
Sbjct: 27914 TVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSG 27973
Query: 671 QLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCI 730
+ L I +V +P R+TW KDG I + I +SL + + H G YT
Sbjct: 27974 ESLRIKALVQGRPVP-RVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVE 28032
Query: 731 ASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSG 790
A NA+ + E ++ V+ P VV P I G+ +W A
Sbjct: 28033 AKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGE-------------KMTLWWDA---- 28075
Query: 791 NPQQYHPVPLTGRIQILPNSSLLIRHVLE---EDIGYYLCQASNGVGTDISKSMFLTVKI 847
P P+T I +S L ++E E Y + NG S +
Sbjct: 28076 -PLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGV 28134
Query: 848 PAMITSHP------NTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIAT 901
+ S P T G + N T I + W + ++ + +Y +
Sbjct: 28135 GRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNS---ITLTWARPES-DGGSEIQQYILER 28190
Query: 902 KDNGD----EVVS-------TLKLKPADRGDSVFFSCHAINS--YGEDRGLIQL-TVQEP 947
++ +V+S K+ G+ F A N+ G G+ +L +EP
Sbjct: 28191 REKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREP 28250
Query: 948 PDPP----ELEIREVKARSMNLRWTQR-FDGNSIITGFDIEYKNKSDSWDFKQSTRNISP 1002
+PP +++ + +++L W++ FDG I G+ IE K+D D+ + +
Sbjct: 28251 VNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIE-MCKADLGDWHKVNAE-AC 28308
Query: 1003 TINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQS 1062
+ + DL Y R+ + N G+ + S E+T G V
Sbjct: 28309 VKTRYTVTDLQAGEEYKFRVSAINGAGKGD-SCEVT---------GTIKAVDRLTAPELD 28358
Query: 1063 IQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLD-------- 1114
I +K IR + I Y + P +S + + ++++T D
Sbjct: 28359 IDANFKQTHVVRAGASIRLF-IAY-QGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVE 28416
Query: 1115 --NLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWS 1172
N +Y + V+ N +G S S + D P PP + +T A + W
Sbjct: 28417 NCNRNDAGKYTLTVE--NNSG---SKSITFTVKVLDTPG-PPGPITFKDVTRGSATLMWD 28470
Query: 1173 EPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQ 1232
P L+G + + + ++ + TR+ ++ + + Y +V A +
Sbjct: 28471 AP---LLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNE 28527
Query: 1233 AGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IRKYTIFCSSP 1291
G G + + P PP + V +S SS V++WL P G I Y +
Sbjct: 28528 YGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQK 28587
Query: 1292 GSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAG----RGNSSEKVTIEPAGK 1347
GS + + +QL + + L +Y V A AG R S + EP +
Sbjct: 28588 GSDFWVEAGH---TKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIE 28644
Query: 1348 APAKIISFGGTVTT-----PWMKDVRLPCNSVGDPAPAVKW------TKDSEDSAIPVSM 1396
A + + T P+ DV + G PAP V W K+++ +I +
Sbjct: 28645 PTADLTGITNQLITCKAGSPFTIDVPIS----GRPAPKVTWKLEEMRLKETDRVSITTTK 28700
Query: 1397 DGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV--QVPPDQPRLTVSKT 1454
D TL ++ DSG Y T NT G T V ++V + P + VS
Sbjct: 28701 D-------RTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVSSV 28753
Query: 1455 SASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKV 1513
SA S L+W P D GG+ I ++++ + W+ V S K+ L Y
Sbjct: 28754 SAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSF 28813
Query: 1514 KLAAKNSVGSGRISEIIEA----KTHGREPSFSKDQHLFTHINSTHARLNL-QGWNNGGC 1568
+++++N G +S+ +E+ H P + + H+++ + + +++GG
Sbjct: 28814 RVSSENRFG---VSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPYHDGGS 28870
Query: 1569 PITAIVLEYRPKGTWAWQGLRANS----SGEVFLTELREATWYELRMRACNSAG 1618
I +E + + T W ++ N +T L E Y+ R A N+AG
Sbjct: 28871 KIIGYWVEKKERNTILW--VKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAG 28922
Score = 115 bits (288), Expect = 5e-25
Identities = 159/695 (22%), Positives = 278/695 (40%), Gaps = 49/695 (7%)
Query: 947 PPDPPEL-EIREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTI 1004
PP PP + + +S +L W + +DG ITG+ +E++ D K +T + I
Sbjct: 20672 PPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTT-GTALRI 20730
Query: 1005 NQANIVDLHPASVYSIRMYSFNKIGRSEPS--KELTISTEEAAPDGPPMDVTLQP--VTS 1060
Q + DL Y+ R+ + N G EP+ ++ I E APD +D L+ V
Sbjct: 20731 TQFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFE-LDAELRRTLVVR 20789
Query: 1061 QSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFA 1120
+ + P K ++ + +++ + +I ++E +TL + +
Sbjct: 20790 AGLSIRIFVPIKGRP-----APEVTWTKDNINLKNRANIE------NTESFTLLIIPECN 20838
Query: 1121 QY--GVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRST 1178
+Y G V G S +N L D P P N+R IT D + W P
Sbjct: 20839 RYDTGKFVMTIENPA-GKKSGFVNVRVL-DTPG-PVLNLRPTDITKDSVTLHWDLP---L 20892
Query: 1179 LNGVLKGYRVIFWSLYVDGEWGEMQNITTTRER---VELRGMEKFTNYSVQVLAYTQAGD 1235
++G G R+ + + + + TT+ ++ G+ + Y +V+A + G
Sbjct: 20893 IDG---GSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGI 20949
Query: 1236 GVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSG 1294
G + + P PP + + + S+V ++W P G I Y I GS
Sbjct: 20950 GEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSD 21009
Query: 1295 QPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRG--NSSEKVTIEPAGKAPAKI 1352
Q + T+ + L + +L G++Y V AV SAGR S V ++ P
Sbjct: 21010 QWT---HITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELD 21066
Query: 1353 IS--FGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLL 1410
+ + V ++++ +G P P V W K + T+ L +
Sbjct: 21067 LRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTW-KKGDQILKQTQRVNFETTATSTILNI 21125
Query: 1411 RAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR--LTVSKTSASSITLTWIPGDN 1468
DSG Y TA N G ++ + V P P + + S+ +T +W P +N
Sbjct: 21126 NECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPEN 21185
Query: 1469 -GGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKN--SVGSGR 1525
GG I +V++ +S W ++ + ++K L G Y+ ++ A+N VG G
Sbjct: 21186 DGGVPISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGI 21245
Query: 1526 ISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAW 1585
S I A + P + + + ++GG PI +E + + W
Sbjct: 21246 TSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILW 21305
Query: 1586 QGL-RANSSGEVFLTE-LREATWYELRMRACNSAG 1618
Q + +A G +F + L + YE R+ A N AG
Sbjct: 21306 QTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAG 21340
Score = 114 bits (286), Expect = 8e-25
Identities = 223/1025 (21%), Positives = 384/1025 (37%), Gaps = 111/1025 (10%)
Query: 667 ASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGN 726
A + LY+P G P +ITW K + G+ I+S +F + L+ +V+ G
Sbjct: 19707 AGVTMRLYVPV---KGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGK 19763
Query: 727 YTCIASNAAATVSRERQLIVRV------PPRFVVQPNNQDGIY---------GKAGVLNC 771
Y N+ +E ++V+V P V+ ++D Y G + ++N
Sbjct: 19764 YILTLENSCG--KKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINY 19821
Query: 772 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN 831
V + W + + L S R E + G
Sbjct: 19822 VVQKRDAERKSWSTVTTECSKTSFRVANLE------EGKSYFFRVFAENEYGI----GDP 19871
Query: 832 GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP 891
G D K A T P + ++ +K +C+ I W+K +
Sbjct: 19872 GETRDAVK---------ASQTPGPVVDLKVRSVSKS-SCS--------IGWKKPHSD-GG 19912
Query: 892 DRVMRYAI--ATKDNG-DEVVSTLKL----KPADRGDSVFFSCHAINSYGEDR-GLIQLT 943
R++ Y + T++N V+ +L L K G F A N GE I +
Sbjct: 19913 SRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTPSEITVV 19972
Query: 944 VQEPPDPPELEIREVKARSMNLRWTQRFDGNSIITGF---DIEYKNKSDSWDFKQSTRNI 1000
++ P+L+++ + + F I G + +K D
Sbjct: 19973 ARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVE 20032
Query: 1001 SPTINQANIV---DLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQP 1057
S +N IV A Y+I + N G E + + + + P GP +
Sbjct: 20033 SSAVNTTLIVYDCQKSDAGKYTITLK--NVAGTKEGTISIKVVGKPGIPTGP---IKFDE 20087
Query: 1058 VTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLK 1117
VT++++ + W AP K+ I Y + R++ N ++ V + + + L
Sbjct: 20088 VTAEAMTLKW-APPKDDGGSEITNYILEKRDSV---NNKW--VTCASAVQKTTFRVTRLH 20141
Query: 1118 KFAQYGVVVQAFNRAGTGPS--SSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPP 1175
+ +Y V A N+ G G S I A DVP PP + + D ++W++P
Sbjct: 20142 EGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPP-NIVDVRHDSVSLTWTDP- 20199
Query: 1176 RSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRER-VELRGMEKFTNYSVQVLAYTQAG 1234
+ T + GY + F + + N T R R ++ G+ + Y +V+A AG
Sbjct: 20200 KKTGGSPITGYHLEFKER--NSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAG 20257
Query: 1235 DGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNG-VIRKYTIFCSSPGS 1293
G S D PP + + + +SV + W P G + Y + S
Sbjct: 20258 VGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPS 20317
Query: 1294 GQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGR----GNSSEKVTIEPAGKAP 1349
+ + PE F + L G +Y + A +AG S+E + + +AP
Sbjct: 20318 KSWMKANHVNVPECAF-TVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAP 20376
Query: 1350 AKIISFGGTVTTPWMKD----------VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH 1399
++ P +KD V + +G P P W+K +D P +
Sbjct: 20377 TIVLD-------PTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIR-PSDITQI 20428
Query: 1400 RLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV-QVPPDQPRLTVSKTSASS 1458
T+ L ++ +D+G YT TATN G V + V VP + +S SA
Sbjct: 20429 TSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEK 20488
Query: 1459 ITLTWIPG-DNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAA 1517
TLTW P ++GGS I+ ++L+ + W V L G Y +++A
Sbjct: 20489 ATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSA 20548
Query: 1518 KNSVGSGRISEIIEAKTHGR-EPSFSKDQHLFTHINSTHARLN-LQGWNNGGCPITAIVL 1575
N G G + K R P ++ +++ A ++ + ++GG IT +
Sbjct: 20549 VNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHV 20608
Query: 1576 EYRPKGTWAW-QGLRANSSG-EVFLTELREATWYELRMRACNSAGCGNETAQFATLDYDG 1633
E R K + W + ++ S +T L+E + YE R+ A N AG G + ++
Sbjct: 20609 ERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKD 20668
Query: 1634 STIPP 1638
+ PP
Sbjct: 20669 AAYPP 20673
Score = 114 bits (285), Expect = 1e-24
Identities = 136/591 (23%), Positives = 232/591 (39%), Gaps = 40/591 (6%)
Query: 1048 GPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGD 1107
GPP V + V+++ +TW P ++ I+ Y + RE S +++V
Sbjct: 20474 GPPGPVEISNVSAEKATLTWTPPLED-GGSPIKSYILEKRETS---RLLWTVVSEDIQSC 20529
Query: 1108 SEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINATTLEDVPSQPPENVRALSITSDV 1166
V T L + +Y V A N G G P SE P PPE ++T +
Sbjct: 20530 RHVAT--KLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNT 20587
Query: 1167 AVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRE--------RVELRGME 1218
A +SW P + GY V E E +++ R R ++ G++
Sbjct: 20588 ATVSWKRPVDDG-GSEITGYHV---------ERREKKSLRWVRAIKTPVSDLRCKVTGLQ 20637
Query: 1219 KFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDV---PGPPAGIKAVPSSASSVVVSWLPPT 1275
+ + Y +V A +AG G S +D PGPP+ ++ S ++W P
Sbjct: 20638 EGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPH 20697
Query: 1276 KPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRG 1334
G+ I Y + G T+ + + L ++Y ++A+ AG G
Sbjct: 20698 YDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVG 20757
Query: 1335 NSSEKVTIEPAGKAPAKIISFGG----TVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDS 1390
+ +E + A T+ +R+ G PAP V WTKD+ +
Sbjct: 20758 EPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINL 20817
Query: 1391 AIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLT 1450
+++ + L++ D+G + T N G + VN+ V P P L
Sbjct: 20818 KNRANIEN---TESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPG-PVLN 20873
Query: 1451 VSKTSAS--SITLTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKC 1507
+ T + S+TL W +P +GGS I ++++ + + + ++K+ L
Sbjct: 20874 LRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSE 20933
Query: 1508 GTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGG 1567
G Y ++ A+N G G +E E PS ++ ST + + ++GG
Sbjct: 20934 GCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGG 20993
Query: 1568 CPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAG 1618
IT V+E + KG+ W + E + L E Y ++ A NSAG
Sbjct: 20994 SKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAG 21044
Score = 113 bits (283), Expect = 2e-24
Identities = 182/774 (23%), Positives = 299/774 (38%), Gaps = 80/774 (10%)
Query: 893 RVMRYAIATKDNGDEV---VSTLK-----LKPADRGDSVFFSCHAINSYGED--RGLIQL 942
++ Y I + G + ++T+K ++ G+ F A+NS G R +
Sbjct: 20995 KITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPV 21054
Query: 943 TVQEPPDPPELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSD-SWD-----FKQS 996
V+E PEL++R + + + + G++I + + K +W KQ+
Sbjct: 21055 IVKEQTMLPELDLRGIYQKLVIAK-----AGDNIKVEIPVLGRPKPTVTWKKGDQILKQT 21109
Query: 997 TRNISPTINQANIVDLHPASVYSIRMYSF---NKIGRSEPSKELTISTEEAAPDGPPMDV 1053
R T + I++++ Y N +G E +TI + P P +
Sbjct: 21110 QRVNFETTATSTILNINECVRSDSGPYPLTARNIVG--EVGDVITIQVHDI-PGPPTGPI 21166
Query: 1054 TLQPVTSQSIQVTWKAPKKELQNGV-IRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYT 1112
V+S + +W P+ + GV I Y + R+ + VE+ T Y
Sbjct: 21167 KFDEVSSDFVTFSWDPPEND--GGVPISNYVVEMRQTD-----STTWVELATTVIRTTYK 21219
Query: 1113 LDNLKKFAQYGVVVQAFNRAGTGP--SSSEINATTLEDVPSQPPENVRALSITSDVAVIS 1170
L +Y V+A NR G GP +S+ I A VP PP + ++T D IS
Sbjct: 21220 ATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPG-PPGTPQVTAVTKDSMTIS 21278
Query: 1171 WSEPPRSTLNGVLKGYRV-------IFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNY 1223
W EP + +L GY V I W + + G+ Y
Sbjct: 21279 WHEPLSDGGSPIL-GYHVERKERNGILWQT--------VSKALVPGNIFKSSGLTDGIAY 21329
Query: 1224 SVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IR 1282
+V+A AG S D PP + + +V + W P G I
Sbjct: 21330 EFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVTLKWAKPEYTGGFKIT 21389
Query: 1283 KYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGR----GNSSE 1338
Y + +G+ + + E F ++ L Y V A +AG S+
Sbjct: 21390 SYIVEKRDLPNGRWLKANFSNILENEF-TVSGLTEDAAYEFRVIAKNAAGAISPPSEPSD 21448
Query: 1339 KVTIEPAGKAPA-KI-ISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSM 1396
+T +AP K+ + F TV + RL + G P P ++W+KD ++ +
Sbjct: 21449 AITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKL 21508
Query: 1397 DGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR--LTVSKT 1454
+ ++ + L+ + DSG YT TATN GGF I N+ V P P L V++
Sbjct: 21509 E-IKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEV 21567
Query: 1455 SASSITLTWIPG-DNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKV 1513
++ L+W P D+GG+ I +++Q + W +V K+ L G Y
Sbjct: 21568 TSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIF 21627
Query: 1514 KLAAKNSVGSGR--ISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPIT 1571
++ A N G G SE + A P K+ + T + ++GG I
Sbjct: 21628 RVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEII 21687
Query: 1572 AIVLEYRPKGTWAWQGLRANSSGEVFLTELR-------EATWYELRMRACNSAG 1618
++E R K W ++ N LT+LR E YE R+ A N+AG
Sbjct: 21688 NYIVERRDKAGQRW--IKCNKK---TLTDLRYKVSGLTEGHEYEFRIMAENAAG 21736
Score = 110 bits (276), Expect = 1e-23
Identities = 158/710 (22%), Positives = 279/710 (39%), Gaps = 60/710 (8%)
Query: 947 PPDPPELEIREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTIN 1005
PP PP + + + ++ L W F+G I G+ ++ K + ++ + T + +
Sbjct: 15002 PPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVD-KQLVGTNEWSRCTEKMIK-VR 15059
Query: 1006 QANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQV 1065
Q + ++ + Y +R+ + N G P + ++ E P PP V L IQ+
Sbjct: 15060 QYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAE--PQEPPA-VELDVSVKGGIQI 15116
Query: 1066 TWKAPKKELQNGVIRGYQIGYR--ENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYG 1123
A K V+ G + + G + +V SE+ D L+K +G
Sbjct: 15117 M--AGKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRK--DHG 15172
Query: 1124 -VVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPR---STL 1179
V+ A N G+ +++ + DVP P +++ + + +++WS+P S +
Sbjct: 15173 RYVITATNSCGSKFAAARVEVF---DVPG-PVLDLKPVVTNRKMCLLNWSDPEDDGGSEI 15228
Query: 1180 NGVL---KGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDG 1236
G + K ++ W Q I T R + ++ G+ + Y +V+A + G G
Sbjct: 15229 TGFIIERKDAKMHTWR----------QPIETERSKCDITGLLEGQEYKFRVIAKNKFGCG 15278
Query: 1237 VRSSVLYIQTKEDV--PGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGS 1293
+ I + + P P + + S++ + W P G I+ Y I
Sbjct: 15279 PPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDK 15338
Query: 1294 GQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTI-----EPAGKA 1348
P F + +L+ Q Y V AV G S + + E
Sbjct: 15339 PDFERVNKRLCPTTSFL-VENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTI 15397
Query: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTK-----DSEDSAIPVSMDGHRLIH 1403
++ G T+ + V +P + G P P ++W+K + A+ ++ +
Sbjct: 15398 KLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSE 15457
Query: 1404 TNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR-LTVSKTSASSITLT 1462
L + ED G YT TA+N G V++ V P PR L V+ A S LT
Sbjct: 15458 AKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLT 15517
Query: 1463 W-IPGDNGGSSIRGFVL--QYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKN 1519
W P DNGGS I +V+ + + EW++V ++ E+ + + L Y+ ++ A N
Sbjct: 15518 WDAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVN 15577
Query: 1520 SVGSGR--ISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEY 1577
G S+ + + R P + + +NGG PIT LE
Sbjct: 15578 KYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPITGYWLEK 15637
Query: 1578 RPKGTWAWQGL------RANSSGEVF-LTELREATWYELRMRACNSAGCG 1620
R +G+ W + + G F + L E Y+ R A N+AG G
Sbjct: 15638 REEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIG 15687
Score = 110 bits (275), Expect = 1e-23
Identities = 150/612 (24%), Positives = 243/612 (39%), Gaps = 41/612 (6%)
Query: 1031 SEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENS 1090
++ K + + P PP D++ + + + ++W P ++ + I Y + E
Sbjct: 18979 TDTQKIKVVVMDAPGPPQPPFDIS--DIDADACSLSWHIPLEDGGSN-ITNYIV---EKC 19032
Query: 1091 PGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGP--SSSEINATTLED 1148
S G + T S + L +Y V+A NR G +S ++ A
Sbjct: 19033 DVSRGDWVTALASVTKTS--CRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFG 19090
Query: 1149 VPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTT 1208
VPS+P +N R + D ++W P + ++ GY +I W + +
Sbjct: 19091 VPSEP-KNARVTKVNKDCIFVAWDRPDSDGGSPII-GY-LIERKERNSLLWVKANDTLVR 19147
Query: 1209 RERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVV 1268
G+ + YS ++ A +AG S T PP + + + S+V
Sbjct: 19148 STEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVS 19207
Query: 1269 VSWLPPTKPNG--VIRKYTIFCSSPGSGQPAPSEYETSPEQL---FYRIAHLNRGQQYLL 1323
+ W P G +I + C PG T+P Q+ Y L QY
Sbjct: 19208 LIWARPKHDGGSKIIGYFVEACKLPGDKWV---RCNTAPHQIPQEEYTATGLEEKAQYQF 19264
Query: 1324 WVAAVTSAGRGNSSEK---VTIEPAGKAPAKI---ISFGGTVTTPWMKDVRLPCNSVGDP 1377
A T+ SE VTI A P +I ++ +T +V L G P
Sbjct: 19265 RAIARTAVNISPPSEPSDPVTIL-AENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKP 19323
Query: 1378 APAVKWTKDSE--DSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTII 1435
P V W KD A + M R + T L L +V +DSG YT TA N+ G +
Sbjct: 19324 MPTVSWKKDGTLLKPAEGIKMAMQRNLCT---LELFSVNRKDSGDYTITAENSSGSKSAT 19380
Query: 1436 VNLLVQVPPDQP-RLTVSKTSASSITLTWIPG-DNGGSSIRGFVLQYSVDNSEEWKDVFI 1493
+ L V P P + ++K + L+W P ++GGS I +++ + W V
Sbjct: 19381 IKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSA 19440
Query: 1494 SSSERSFKLDSLKCGTWYKVKLAAKNSVGSGR--ISEIIEAKTHGREPSFSKDQHLFTHI 1551
+ S ++ L G Y+ ++ A+N G G +E AK + +P D + ++I
Sbjct: 19441 TVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAK-NPYDPPGRCDPPVISNI 19499
Query: 1552 NSTHARLNLQ-GWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFL--TELREATWYE 1608
H ++ + ++GG PIT +LE R W + E L T L+E T YE
Sbjct: 19500 TKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYE 19559
Query: 1609 LRMRACNSAGCG 1620
R+ A N AG G
Sbjct: 19560 FRVTAINKAGPG 19571
Score = 110 bits (274), Expect = 2e-23
Identities = 151/623 (24%), Positives = 239/623 (38%), Gaps = 87/623 (13%)
Query: 944 VQEPPDPPELEIREVKARSMNLRWTQRF-DGNSIITGFDIEY-KNKSDSWDFKQSTRNIS 1001
++ P P L + S+ L+W DG S I G+ IE + D+W + +
Sbjct: 13289 IERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWI--RCNMKLV 13346
Query: 1002 PTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVT-----LQ 1056
P + + L + Y R+ + NK G S+PS+ L T + A P MD++ L+
Sbjct: 13347 PELTY-KVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLE 13405
Query: 1057 PVTSQSIQV------------TWKAPKKELQNG--VIRGYQIGYRENSPGSNGQYSIVEM 1102
+ I + TW K L+ G V Y E ++
Sbjct: 13406 VIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKMKTLSAYAE---------LVISP 13456
Query: 1103 KATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSI 1162
D +YTL + NR T ++N PS P E ++ I
Sbjct: 13457 SERSDKGIYTL-------------KLENRVKTISGEIDVNVIAR---PSAPKE-LKFGDI 13499
Query: 1163 TSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTN 1222
T D ++W EPP L GY V+ W ++ + T E + + +
Sbjct: 13500 TKDSVHLTW-EPPDDDGGSPLTGY-VVEKREVSRKTWTKVMDFVTDLE-FTVPDLVQGKE 13556
Query: 1223 YSVQVLAYTQAGDGVRSSV---LYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNG 1279
Y +V A + G G + V + + T VP PP +K +A+S+ ++W PP G
Sbjct: 13557 YLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGG 13616
Query: 1280 V-IRKYTIFCSSPGS------GQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAG 1332
I+ Y + GS G+P ET E + L G+ Y V A+ G
Sbjct: 13617 SRIKGYIVERCPRGSDKWVACGEPVA---ETKME-----VTGLEEGKWYAYRVKALNRQG 13668
Query: 1333 RGNSS---EKVTIEPAGKAPAKIISFG--GTVTTPWMKDVRLPCNSVGDPAPAVKWTKDS 1387
S E++ +AP + +T + LP G P P + WTK
Sbjct: 13669 ASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKAD 13728
Query: 1388 ----EDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP 1443
+D I + + T+ + K D+G Y A N G T +V + V
Sbjct: 13729 MILKQDKRITIEN-----VPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDK 13783
Query: 1444 PDQPR-LTVSKTSASSITLTWIPG-DNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFK 1501
P P ++ + S LTW P D+GGS I +V++ +SE W + + + +FK
Sbjct: 13784 PGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFK 13843
Query: 1502 LDSLKCGTWYKVKLAAKNSVGSG 1524
L Y ++AA+N G G
Sbjct: 13844 ATKLIPNKEYIFRVAAENMYGVG 13866
Score = 110 bits (274), Expect = 2e-23
Identities = 156/653 (23%), Positives = 252/653 (38%), Gaps = 41/653 (6%)
Query: 989 DSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSF---NKIGRSEPSKELTISTEEAA 1045
D+ KQ+TR + + +++ + A + Y N G + + + + +
Sbjct: 22184 DNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGP 22243
Query: 1046 PDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKAT 1105
P GP V + VT+ SI ++W PK + I Y + R+ S + + IV AT
Sbjct: 22244 PTGP---VKMDEVTADSITLSWGPPKYD-GGSSINNYIVEKRDTSTTT---WQIVS--AT 22294
Query: 1106 GDSEVYTLDNLKKFAQYGVVVQAFNRAG--TGPSSSEINATTLEDVPSQPPENVRALSIT 1163
LK +Y + A NR G T +S A VP P V LS +
Sbjct: 22295 VARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLS-S 22353
Query: 1164 SDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGE----WGEMQNITTTRERVELRGMEK 1219
D + W+EP G RVI + L W ++ + + + G+E+
Sbjct: 22354 RDSMEVQWNEPISDG------GSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEE 22407
Query: 1220 FTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNG 1279
Y +V A G G S V D PP +A+ + +SV + W PT G
Sbjct: 22408 GVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGG 22467
Query: 1280 -VIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAG----RG 1334
I Y + G+ + + T+ + + L +Y V A +AG
Sbjct: 22468 SKITGYIVEKKELPEGRWMKASF-TNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPS 22526
Query: 1335 NSSEKVTIEPAGKAPAKII--SFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAI 1392
S+ +T P + + T+ + ++ + G P P ++W K ++ +
Sbjct: 22527 ESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSN 22586
Query: 1393 PVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR--LT 1450
++ + AV+ DSG Y A N G ++ VN+ V P P +
Sbjct: 22587 TARLEIKSTDFATSLSVKDAVRV-DSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVV 22645
Query: 1451 VSKTSASSITLTWIPG-DNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGT 1509
+S +A TL W P +GGS I ++++ + W V + S K+ L G
Sbjct: 22646 ISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGN 22705
Query: 1510 WYKVKLAAKNSVGSGR--ISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGG 1567
Y ++ A N G G SE + AK P K + T + + + ++GG
Sbjct: 22706 EYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERPASDGG 22765
Query: 1568 CPITAIVLEYRPKGTWAWQGLRANSSGEVFL--TELREATWYELRMRACNSAG 1618
I VLE R K W GE+ L T L E YE R+ A N+AG
Sbjct: 22766 SEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAG 22818
Score = 109 bits (273), Expect = 2e-23
Identities = 155/632 (24%), Positives = 251/632 (39%), Gaps = 68/632 (10%)
Query: 1026 NKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIG 1085
N +G + L + P GP + + V++ + ++W PK + I Y I
Sbjct: 16200 NNLGTASKEMRLNVLGRPGPPVGP---IKFESVSADQMTLSWFPPKDD-GGSKITNYVIE 16255
Query: 1086 YRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEIN-A 1143
RE + + + V + + YT+ L + +Y + A N+ G G P SE A
Sbjct: 16256 KREAN-----RKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETA 16310
Query: 1144 TTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQ 1203
L VP P + S+T + ++W EP + V G W EM+
Sbjct: 16311 RNLFSVPGAP-DKPTVSSVTRNSMTVNWEEPEYDGGSPVT-------------GYWLEMK 16356
Query: 1204 NITTTR-ERV--------------ELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKE 1248
+ T+ R +RV ++ G+ + ++Y +V A AG G S T
Sbjct: 16357 DTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATAR 16416
Query: 1249 DV---PGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQ-PAPSEYET 1303
D PGPP K + SS + W PP K G + Y + G + + E
Sbjct: 16417 DPIAPPGPPFP-KVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEV 16475
Query: 1304 SPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKV-TIEPAGKAPAKIISFGGTVTTP 1362
+L + L G Y V AV AG G E IE + + + +V
Sbjct: 16476 RGTKLV--VTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDR 16533
Query: 1363 WMKD----VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDS 1418
+ +R+ G P P V W + +++ + + +++++ +
Sbjct: 16534 IVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAI---SSSMVIKNCQRSHQ 16590
Query: 1419 GYYTCTATNTGGF--DTIIVNLL-VQVPPDQPRLTVSKTSASSITLTWI-PGDNGGSSIR 1474
G Y+ A N G TIIV++L V P P L + T+ S LTW P D+GGS I
Sbjct: 16591 GVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLTN-ESCKLTWFSPEDDGGSPIT 16649
Query: 1475 GFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKT 1534
+V++ + W V + + ++ + L G Y ++AA+NS+G G E EA
Sbjct: 16650 NYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALV 16709
Query: 1535 HGREPSFSKDQHLFTHINSTHARLNLQGWN----NGGCPITAIVLEYRPKGTWAWQGLRA 1590
REP ++ + WN +GG I VLE R GT + +
Sbjct: 16710 I-REPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTN 16768
Query: 1591 NS--SGEVFLTELREATWYELRMRACNSAGCG 1620
++ S + + L+E YE R+ A N G G
Sbjct: 16769 DNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQG 16800
Score = 107 bits (268), Expect = 9e-23
Identities = 149/659 (22%), Positives = 264/659 (40%), Gaps = 77/659 (11%)
Query: 911 TLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP--ELEIREVKARSMNLRW- 967
TL + + R D+ ++ A+N+ G ++L V P PP ++ V A M L W
Sbjct: 16180 TLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWF 16239
Query: 968 TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNK 1027
+ DG S IT + IE + + S+ T +++ H Y R+ + NK
Sbjct: 16240 PPKDDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHE---YVFRIMAQNK 16296
Query: 1028 IG-----RSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGY 1082
G SEP + + APD P T+ VT S+ V W+ P+ + + GY
Sbjct: 16297 YGIGEPLDSEPETARNLFSVPGAPDKP----TVSSVTRNSMTVNWEEPEYD-GGSPVTGY 16351
Query: 1083 QIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEIN 1142
+ ++ + + + +KA Y + L + + Y V A N AG GP+S +
Sbjct: 16352 WLEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSD 16411
Query: 1143 ATTLEDVPSQP-PENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGE 1201
T D + P P + T A + WS PP + GY ++ + EW +
Sbjct: 16412 PATARDPIAPPGPPFPKVTDWTKSSADLEWS-PPLKDGGSKVTGY-IVEYKEEGKEEWEK 16469
Query: 1202 MQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVL-YIQTKEDVPGPPAGIKA- 1259
++ ++ + G+++ Y +V A AG G V I+ K+ + P + A
Sbjct: 16470 GKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDAS 16529
Query: 1260 ----VPSSASSVV-----VSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFY 1310
+ A V+ VS PP + + T+ P + ET+
Sbjct: 16530 VRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTL---------PQEATIETTAISSSM 16580
Query: 1311 RIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLP 1370
I + R Q + + A AG K TI ++ G V TP++
Sbjct: 16581 VIKNCQRSHQGVYSLLAKNEAG----ERKKTI------IVDVLDVPGPVGTPFL------ 16624
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVS------MDGHRLIHTNGTLLLRAVKAEDSG----- 1419
+++ + + + W +D P++ + R T T + A G
Sbjct: 16625 AHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGK 16684
Query: 1420 --YYTCTATNTGGF-------DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGD-NG 1469
++ A N+ G + +++ + VP L V + + +++TLTW P +G
Sbjct: 16685 AYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDG 16744
Query: 1470 GSSIRGFVLQYSVDNSEEWKDVFISS-SERSFKLDSLKCGTWYKVKLAAKNSVGSGRIS 1527
GS I +VL+ + +E++ V + R + + LK G Y+ +++A N VG G+ S
Sbjct: 16745 GSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPS 16803
Score = 107 bits (268), Expect = 9e-23
Identities = 297/1449 (20%), Positives = 517/1449 (35%), Gaps = 229/1449 (15%)
Query: 299 AGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG----LTISDLRTEDSGTYIC 354
AG T L G P+P I WL+ + + +R + T L + D D G YI
Sbjct: 23639 AGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYIL 23698
Query: 355 EVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSP----------EF 404
+N GS + V+D P ++ TG+ S C+LT SP +
Sbjct: 23699 RASNVAGSKSFPVNVKVLDRPGPPEGPVQV-TGVTSE---KCSLTWSPPLQDGGSDISHY 23754
Query: 405 TIRWYRNTEL---VLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAII 461
+ + L V+ E ++ +L +T + + ++ A K +
Sbjct: 23755 VVEKRETSRLAWTVVASEVVT------NSLKVTKLLEGNEYVFRIMAVNKYGVGEP---- 23804
Query: 462 ALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTM 521
LE + + F V PG SL TV W D DG Y +
Sbjct: 23805 -LESAPVLMKNPF----VLPGPPKSLEVTNIAKDSMTVCWNRPDS----DGGSEIIGYIV 23855
Query: 522 S--DGTTI-----SHMNVTGPQIRDGGV-------YRCTARNLVGSAE-------YQARI 560
D + I + +T ++R G+ +R +A N G E Y+A
Sbjct: 23856 EKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACD 23915
Query: 561 NV--RGPPS----IRAMRNITAVAGRDTLIN--CRVIGYPYYSIKWYKDALLLPDNHRQV 612
V GPP+ + +N +A + + ++GY K + Q+
Sbjct: 23916 PVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICK-------ADEEEWQI 23968
Query: 613 VFENGTLKLT--DVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQP---FEFPPA 667
V L++T ++ K + EY V ++ + + A VP ++P E P
Sbjct: 23969 VTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGE----ATSVPGTVKPEDKLEAPEL 24024
Query: 668 SIGQLLYIPCVVSSGD-----MPIR------ITW-RKDGQVIISGSGVTIESKEFMSSLQ 715
+ L VV +G +P + ITW R++G+ V IE + L
Sbjct: 24025 DLDSELRKGIVVRAGGSARIHIPFKGRPTPEITWSREEGEFT---DKVQIEKGVNYTQLS 24081
Query: 716 ISSVSLKHNGNYTCIASNAAATVSRERQLIVRV------PPRFVVQPNNQDGIY------ 763
I + G Y N++ S+ + V+V P V+ +D +
Sbjct: 24082 IDNCDRNDAGKYILKLENSSG--SKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPP 24139
Query: 764 ---GKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEE 820
G A V N +D + + + + +S + ++ E
Sbjct: 24140 IIDGGAKVKNYVIDKRESTRKAYANVSSKCS-----------------KTSFKVENLTEG 24182
Query: 821 DIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIII 880
I Y+ A N G + VK A S P ++ T + +
Sbjct: 24183 AIYYFRVMAENEFGVGVPVETVDAVKA-AEPPSPPG----------KVTLTDVSQTSASL 24231
Query: 881 RWEKGDTVIDPDRVMRYAIATKDNGDE---VVSTLKLKPA-----DRGDSVFFSCHAINS 932
WEK + RV+ Y + + G E +V+ K+ A G F A N
Sbjct: 24232 MWEKPEHD-GGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNE 24290
Query: 933 YGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQR--FDGNSIITGFDIEYK----- 985
G+ DP L + V A+ + ++ + + F+ SI G D++ +
Sbjct: 24291 KGKS------------DPRVLGV-PVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIG 24337
Query: 986 --NKSDSW-----DFKQSTR-NISPTINQA--NIVDLHPASVYSIRMYSFNKIGRSEPSK 1035
+ SW KQ+TR N+ T +I + + + + N G + +
Sbjct: 24338 RPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENL 24397
Query: 1036 ELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNG 1095
+ + + P GP V V++ + ++W+ P I Y + R+ + +
Sbjct: 24398 SVIVLEKPGPPVGP---VRFDEVSADFVVISWEPPAYT-GGCQISNYIVEKRDTTTTTWH 24453
Query: 1096 QYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAG-TGPSSSEINATTLEDVPSQPP 1154
S + T + LK +Y + A NR G + P S+ PP
Sbjct: 24454 MVSATVARTT-----IKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPP 24508
Query: 1155 ENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGE----WGEMQNITTTRE 1210
SI+ D ++ W EP G ++I + L + W ++
Sbjct: 24509 GTPFVTSISKDQMLVQWHEPVNDG------GTKIIGYHLEQKEKNSILWVKLNKTPIQDT 24562
Query: 1211 RVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVS 1270
+ + G+++ Y +V A G G S V D PP +A+ + ++V +
Sbjct: 24563 KFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVTLK 24622
Query: 1271 WLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVT 1329
W P G I Y + G+ + + T+ + + ++ L Q+Y V A
Sbjct: 24623 WKKPAYDGGSKITGYIVEKKDLPDGRWMKASF-TNVLETEFTVSGLVEDQRYEFRVIARN 24681
Query: 1330 SAGR----GNSSEKVTIEPAGKAPAKIIS--FGGTVTTPWMKDVRLPCNSVGDPAPAVKW 1383
+AG +SS +T AP + + + + L + G P P V W
Sbjct: 24682 AAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVW 24741
Query: 1384 TKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP 1443
+KD ++ + + TL+++ D G Y +N GG +I + + V
Sbjct: 24742 SKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDR 24801
Query: 1444 PDQPR--LTVSKTSASSITLTWIPG-DNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSF 1500
P P L V+ +A L W P +GG++I ++++ + W V ++
Sbjct: 24802 PGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQVSTEVQALNY 24861
Query: 1501 KLDSLKCGTWYKVKLAAKNSVGSGRISEI--IEAKTHGREPSFSKDQHLFTHINSTHARL 1558
K+ L G Y ++ A N G G E + A + P + +
Sbjct: 24862 KVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVT 24921
Query: 1559 NLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELR-------EATWYELRM 1611
+ ++GG I +LE R K +G+R + LT+LR E YE R+
Sbjct: 24922 WARPVDDGGTEIEGYILEKRDK-----EGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRV 24976
Query: 1612 RACNSAGCG 1620
A N+AG G
Sbjct: 24977 AAENAAGVG 24985
Score = 107 bits (267), Expect = 1e-22
Identities = 178/787 (22%), Positives = 295/787 (37%), Gaps = 84/787 (10%)
Query: 880 IRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLK--------LKPADRGDSVFFSCHAIN 931
I+WEK ++ ++ Y + + G E ST + G+ F A+N
Sbjct: 25314 IKWEKPESD-GGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVN 25372
Query: 932 SYG--EDRGL-IQLTVQEPPDPPELEIR----EVKARSMNLRWTQRFDGNSIITGFDIEY 984
G + R L + + ++ P +E+ VKAR L+ F G T
Sbjct: 25373 EKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQ-LKIDVPFKGRPQAT-----V 25426
Query: 985 KNKSDSWDFKQSTR---NISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTIST 1041
+ D K++TR + S T+ +I + V + + N G S + I+
Sbjct: 25427 NWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAG----SITVPITI 25482
Query: 1042 EEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGV-IRGYQIGYRENSPGSNGQYSIV 1100
GPP + + V+ SI ++W P E G I Y + +E + + + IV
Sbjct: 25483 IVLDRPGPPGPIRIDEVSCDSITISWNPP--EYDGGCQISNYIVEKKETTSTT---WHIV 25537
Query: 1101 EMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDV--PSQPPENVR 1158
S + L ++Y V A NR G S SE +A E P PP +
Sbjct: 25538 SQAVARTS--IKIVRLTTGSEYQFRVCAENRYGKS-SYSESSAVVAEYPFSPPGPPGTPK 25594
Query: 1159 ALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGE----WGEMQNITTTRERVEL 1214
+ T +++W P G RVI + L W + I ++++
Sbjct: 25595 VVHATKSTMLVTWQVPVNDG------GSRVIGYHLEYKERSSILWSKANKILIADTQMKV 25648
Query: 1215 RGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPP 1274
G+++ Y +V A AG G S D PP + + SV + W P
Sbjct: 25649 SGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPCDPPGQPEVTNITRKSVSLKWSKP 25708
Query: 1275 TKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGR 1333
G I Y + G+ Y T+ ++ ++ + L Q+Y V A +A
Sbjct: 25709 HYDGGAKITGYIVERRELPDGRWLKCNY-TNIQETYFEVTELTEDQRYEFRVFARNAADS 25767
Query: 1334 GNSSEKVT---IEPAGKAPAKI---ISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDS 1387
+ + T I P ++ + F + + +++ + G P P + W KD
Sbjct: 25768 VSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDG 25827
Query: 1388 ---EDSAIP--VSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQV 1442
E+ A +S D H L L ++ D+G Y T N G ++ VN V
Sbjct: 25828 IEIEERARTEIISTDNHTL------LTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLD 25881
Query: 1443 PPDQPR--LTVSKTSASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERS 1499
P P L ++ +A +L+W P ++GG+ I ++++ + W S
Sbjct: 25882 KPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTS 25941
Query: 1500 FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLN 1559
K+ L G Y ++ N G G E + K +P I S
Sbjct: 25942 CKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIK--ALDPFTVPSPPTSLEITSVTKESM 25999
Query: 1560 LQGW----NNGGCPITAIVLEYRPKGTWAWQGLRANSSG----EVFLTELREATWYELRM 1611
W ++GG I+ ++E R K + W +R N V T LRE YE R+
Sbjct: 26000 TLCWSRPESDGGSEISGYIIERREKNSLRW--VRVNKKPVYDLRVKSTGLREGCEYEYRV 26057
Query: 1612 RACNSAG 1618
A N+AG
Sbjct: 26058 YAENAAG 26064
Score = 107 bits (267), Expect = 1e-22
Identities = 243/1167 (20%), Positives = 434/1167 (37%), Gaps = 175/1167 (14%)
Query: 478 VVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQI 537
+V G F++ +G P P V W+ D + RT Y + + S + +
Sbjct: 26197 IVKAGASFTMTVPFRGRPVPNVLWSKPDTDL------RTRAYVDTTDSRTS-LTIENANR 26249
Query: 538 RDGGVYRCTARNLVGSAEYQARINV---RGPPSIRAMRNIT---AVAGRDTLIN---CRV 588
D G Y T +N++ +A + V GPP+ ++++T AV D N V
Sbjct: 26250 NDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPV 26309
Query: 589 IGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQS 648
Y + K A + N+ + + K+T++Q+G + + +
Sbjct: 26310 KNYHIEKREASKKAWVSVTNNCNRL----SYKVTNLQEGA-----IYYFRVSGENEFGVG 26360
Query: 649 VHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRK---DG---------QV 696
+ K I PP +G V S + +TW K DG +
Sbjct: 26361 IPAETKEGVKITEKPSPPEKLG-------VTSISKDSVSLTWLKPEHDGGSRIVHYVVEA 26413
Query: 697 IISGSGVTIESKEFMSSLQISSVSLKHNGNY--TCIASNAAATVSRERQLIVRV------ 748
+ G ++ S+ + S L+ N Y A N A +S R+L++ V
Sbjct: 26414 LEKGQKNWVKCAVAKSTHHVVS-GLRENSEYFFRVFAENQAG-LSDPRELLLPVLIKEQL 26471
Query: 749 -PPRFVVQPNNQDGIYGKAG---VLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRI 804
PP ++ +Y +AG ++ + G P PKV VPL +
Sbjct: 26472 EPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSR----------DGVPLKATM 26521
Query: 805 QI-----LPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTI 859
+ N ++ ++ + D G Y A+N GT +K+ + I + P T
Sbjct: 26522 RFNTEITAENLTINLKESVTADAGRYEITAANSSGT--TKAF---INIVVLDRPGPPTGP 26576
Query: 860 AIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADR 919
+ E + T + E P + I R A+ T+ + + +K+
Sbjct: 26577 VVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATVARTMMKVMKLTT 26636
Query: 920 GDSVFFSCHAINSYGEDRGLIQ--LTVQEP---PDPPELE-IREVKARSMNLRWTQRF-D 972
G+ F A N +G + +TV+ P P PP + V S+ + W + +
Sbjct: 26637 GEEYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSN 26696
Query: 973 GNSIITGFDIEYKNK-SDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRS 1031
G S + G+ +E K++ S W Q + + + +Y R+Y+ N G
Sbjct: 26697 GGSAVVGYHLEMKDRNSILW---QKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVG 26753
Query: 1032 EPS--KELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYREN 1089
+PS E ++ + PP +V + ++ S+ ++W+ P + I GY + R+
Sbjct: 26754 KPSHPSEPVLAIDACE---PPRNVRITDISKNSVSLSWQQPAFD-GGSKITGYIVERRDL 26809
Query: 1090 SPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEI--NATTLE 1147
G + S + T + + L + +QY V A N G+ + SE+ T ++
Sbjct: 26810 PDGRWTKASFTNVTET----QFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCID 26865
Query: 1148 -------DVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWG 1200
D+P + E V+ + TS S P T+ W Y D +
Sbjct: 26866 SYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIE----------W--YKDDK-- 26911
Query: 1201 EMQ-------NITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGP 1253
E+Q TT + ++ ++ + ++ G S+ + +Q D PGP
Sbjct: 26912 ELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSA--SATIRVQIL-DKPGP 26968
Query: 1254 PAG-IKAVPSSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYR 1311
P G I+ +A + + W PP G I Y + + + S E+
Sbjct: 26969 PGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIV--EKRETSRVVWSMVSEHLEECIIT 27026
Query: 1312 IAHLNRGQQYLLWVAAVTSAGRGNSSEK---------VTIEPAGKAPAKIISFGGTVTTP 1362
+ +G +Y+ V AV G G E VT P G I+ ++T
Sbjct: 27027 TTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKIT-KNSMTVV 27085
Query: 1363 WMKDVRLPCNSVGD------PAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAE 1416
W + + + + ++ W K +++ I + +
Sbjct: 27086 WSRPIADGGSDISGYFLEKRDKKSLGWFKVLKET-----------IRDTRQKVTGLTENS 27134
Query: 1417 DSGYYTC--TATNTGGFDTIIVNLLVQVPPDQP----RLTVSKTSASSITLTWI-PGDNG 1469
D Y C A G F P D P ++ ++ ++ SSITL W P +G
Sbjct: 27135 DYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSITLGWSKPVYDG 27194
Query: 1470 GSSIRGFVLQYSVDNSEEWKDVFISSSERS--FKLDSLKCGTWYKVKLAAKNSVGSG--- 1524
GS++ G+V++ EEW V R+ + + +LK G Y +++A N G G
Sbjct: 27195 GSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPI 27254
Query: 1525 RISEIIEAKTHGREPSFSKDQHLFTHI 1551
++E ++AK P D L T +
Sbjct: 27255 EMNEPVQAKDILEAPEIDLDVALRTSV 27281
Score = 106 bits (264), Expect = 3e-22
Identities = 165/710 (23%), Positives = 285/710 (40%), Gaps = 80/710 (11%)
Query: 382 KKLKTGIGSTVILSCALTGSPEFTIRWYR-NTELVLPDEAISIRGLSNETLLITSAQKSH 440
K + T +G LSC + G P I+WYR EL+ + TL + + ++
Sbjct: 30540 KDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQED 30599
Query: 441 SGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSF--SEKVVNP-GEQFSLMCAAKGAPPP 497
G Y C AT + + + + L+ TP+ + EK G L G P P
Sbjct: 30600 EGVYTCIATNEVGEVETSSKLLLQ-ATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVP 30658
Query: 498 TVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRD-GGVYRCTARNLVGSAEY 556
+TW + + + T+ + +H+ + Q + G Y+ N+ G+ +
Sbjct: 30659 AMTWFHGQKLL-----QNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDA 30713
Query: 557 QARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSI---KWYKDALLLPDNHR--- 610
+ ++ P + + L N VI + + W + ++ +
Sbjct: 30714 ILDVEIQDKPD----KPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGA 30769
Query: 611 --QVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPA- 667
Q+V ++ + + Y V Q IS + V+ V + PFE P A
Sbjct: 30770 EWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVS-SVVIIKSPFEKPGAP 30828
Query: 668 ---SIGQLLYIPCVV------SSGDMPIRITW-----RKDGQVIISGSGVTIESKEFMSS 713
+I + CVV S G IR + +K + I S T E +E + S
Sbjct: 30829 GKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWI---SVTTEEIRETVFS 30885
Query: 714 LQISSVSLKHNGNYTCIASNAAATVSRERQLIVR---VP---PRFVVQPNNQDGIYGKAG 767
++ L++ C + S + I VP P F + N + Y
Sbjct: 30886 VKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNA 30945
Query: 768 VLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNS--SLLIRHVLEEDIGYY 825
L C V G+P P V W + +G ++ L RIQ L+I V ++D Y
Sbjct: 30946 TLVCKVTGHPKPIVKW-YRQG----KEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVY 31000
Query: 826 LCQASNGVGTDISKSMFLTVKIPAMITSHPNTTI-------AIKGHAKELNCTARGERPI 878
+A+N G+ +S + L V++PA I H T+ A++G + G+
Sbjct: 31001 QVRATNQGGS-VSGTASLEVEVPAKI--HLPKTLEGMGAVHALRGEVVSIKIPFSGKPDP 31057
Query: 879 IIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRG 938
+I W+KG +ID + + + S + +R D+ F+ A N +G D+
Sbjct: 31058 VITWQKGQDLIDNNGHYQVIVTRS-----FTSLVFPNGVERKDAGFYVVCAKNRFGIDQK 31112
Query: 939 LIQLTVQEPPDPPE-LEIREVKARSMNLRWTQ-RFDGNSIITGFDIE-YKNKSDSWDFKQ 995
++L V + PDPP +++ +V S+NL WT+ DG S IT + +E ++ W
Sbjct: 31113 TVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWLRVG 31172
Query: 996 STRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSK--ELTISTEE 1043
R T +++L + Y R+ + NK G S+PS+ E TI+ E+
Sbjct: 31173 QARETRYT-----VINLFGKTSYQFRVIAENKFGLSKPSEPSEPTITKED 31217
Score = 103 bits (256), Expect = 2e-21
Identities = 156/736 (21%), Positives = 286/736 (38%), Gaps = 83/736 (11%)
Query: 948 PDPPE-LEIREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNK-SDSWDFKQSTRNISPTI 1004
PDPPE ++ R+ A S+ L W + DG S I G+ +E + SD W ++ T
Sbjct: 13588 PDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKW--VACGEPVAET- 13644
Query: 1005 NQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQ 1064
+ + L Y+ R+ + N+ G S+PS+ + P + + ++ + +++
Sbjct: 13645 -KMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVK 13703
Query: 1065 VTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGV 1124
K G P ++ +M D + T++N+ K + +
Sbjct: 13704 AGTKIELPATVTG------------KPEPKITWTKADMILKQDKRI-TIENVPKKSTVTI 13750
Query: 1125 V-----------VQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSE 1173
V ++A N G + E+N D P PP +T++ +++W+
Sbjct: 13751 VDSKRSDTGTYIIEAVNVCGRATAVVEVNVL---DKPG-PPAAFDITDVTNESCLLTWN- 13805
Query: 1174 PPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQA 1233
PPR + Y + D E + T + + Y +V A
Sbjct: 13806 PPRDDGGSKITNY--VVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMY 13863
Query: 1234 GDG--VRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNG-VIRKYTIFCSS 1290
G G V++S + + + D PGPP ++ + +V ++W P G I Y +
Sbjct: 13864 GVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLD 13923
Query: 1291 PGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPA 1350
P + + + + YR+ L ++Y V A AG G S+ + EP
Sbjct: 13924 PDTDKWVRCN-KMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSK--STEP------ 13974
Query: 1351 KIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLL 1410
I + PW + VG + + WTK D + ++ T +
Sbjct: 13975 --ILIKDPIDPPWPPG-KPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWV 14031
Query: 1411 RAVKA------------EDSGY-YTCTATNTGG-------FDTIIVNLLVQVPPDQPR-L 1449
R + E Y + A N G D ++ + PP PR L
Sbjct: 14032 RVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKL-YPPSPPRWL 14090
Query: 1450 TVSKTSASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCG 1508
V + ++ L W +P +GGS I ++++ + W+ V + + + L G
Sbjct: 14091 EVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEG 14150
Query: 1509 TWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGW----N 1564
+ Y ++AA+N++G +EI ++ + + ++ T ++L+ W N
Sbjct: 14151 SLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLK-WEPPKN 14209
Query: 1565 NGGCPITAIVLEYRPK-GT-WAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCGNE 1622
+GG PI V+E + + GT W G A +T++ E T + ++RA N AG G+
Sbjct: 14210 DGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHP 14269
Query: 1623 TAQFATLDYDGSTIPP 1638
+ L + T PP
Sbjct: 14270 SEPTEILSIEDPTSPP 14285
Score = 103 bits (256), Expect = 2e-21
Identities = 230/1093 (21%), Positives = 403/1093 (36%), Gaps = 156/1093 (14%)
Query: 609 HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPAS 668
H N + D++ G + +V ++ S+S+ ++ P ++ E P
Sbjct: 29392 HTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESI---AEIEP-VERIEIPDLE 29447
Query: 669 IGQLLYIPCVVS-----------SGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQIS 717
+ L + SG P ITW K G I S I++ E S L +
Sbjct: 29448 LADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQG--IDLASRAIIDTTESYSLLIVD 29505
Query: 718 SVSLKHNGNYTCIASNAAATVSRERQLIVRVP------PRFVVQPNNQDGIY-------- 763
V+ G YT A N + + ++V+V P V+ ++D +
Sbjct: 29506 KVNRYDAGKYTIEAENQSG--KKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTI 29563
Query: 764 -GKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDI 822
G A V N V+ +K + Y RI L ++ VL E+I
Sbjct: 29564 DGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLY-------RISGLVEGTMYYFRVLPENI 29616
Query: 823 GYYL---CQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPII 879
Y + C+ S+ V +S+ + K+ + + T+A
Sbjct: 29617 -YGIGEPCETSDAVL--VSEVPLVPAKLEVVDVTKSTVTLA------------------- 29654
Query: 880 IRWEKGDTVIDPDRVMRYAI-ATKDNGDEVVSTLKLKPA---------DRGDSVFFSCHA 929
WEK R+ Y + A K + + + LKP + G+ F A
Sbjct: 29655 --WEK-PLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRA 29711
Query: 930 INSYG--EDRGLIQ-LTVQEPPDPPELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKN 986
N G E R + +TVQ+ P +++ + +++++ + + I G
Sbjct: 29712 QNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAG----RPP 29767
Query: 987 KSDSWDF-----KQSTRNISPTINQANIVDLHPASVYSIRMYSF---NKIGRSEPSKELT 1038
+ SW F ++S R T + + + ++ Y+ N G + + ++
Sbjct: 29768 PAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVI 29827
Query: 1039 ISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGV-IRGYQIGYRE-NSPGSNGQ 1096
I + P GP + + + + SI ++W+ P EL G + GY + R+ + PG
Sbjct: 29828 ILDKPGPPTGP---IKIDEIDATSITISWEPP--ELDGGAPLSGYVVEQRDAHRPG---- 29878
Query: 1097 YSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGP--SSSEINATTLEDVPSQPP 1154
+ V T + +T L + +Y V A NR G G S I + +P PP
Sbjct: 29879 WLPVSESVTRSTFKFT--RLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPG-PP 29935
Query: 1155 ENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVEL 1214
E ++ ++ D ++W PP + GY V + D W + + T R
Sbjct: 29936 ETLQIFDVSRDGMTLTWY-PPEDDGGSQVTGYIVERKEVRAD-RWVRVNKVPVTMTRYRS 29993
Query: 1215 RGMEKFTNYSVQVLAYTQAGDGVRS---SVLYIQTKEDVPGPPAGIKAVPSSASSVVVSW 1271
G+ + Y +V A G G S + PG P + ++ +SV ++W
Sbjct: 29994 TGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAW 30053
Query: 1272 LPPTKPNG-VIRKYTIFCSSPGSGQPAPSEYETSPEQL-FYRIAHLNRGQQYLLWVAAVT 1329
P G + Y I Q ++ T+P ++ Y + HL +G +Y V A
Sbjct: 30054 SVPEDEGGSKVTGYLI--EMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACN 30111
Query: 1330 SAGRGNSSE-----KVT-------IEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDP 1377
+ G G +E KVT E + I G V +RL G P
Sbjct: 30112 AGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGV-------IRLTIPIKGKP 30164
Query: 1378 APAVKWTKDSEDSAIPVSMDGHRLIHTNGT---LLLRAVKAEDSGYYTCTATNTGGFDTI 1434
P KWTK+ +D + +I T+ T L+++ DSG Y N G +
Sbjct: 30165 FPICKWTKEGQD------ISKRAMIATSETHTELVIKEADRGDSGTYDLVLENKCGKKAV 30218
Query: 1435 IVNLLVQVPPDQPR--LTVSKTSASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDV 1491
+ + V P+ P L S+ ++W P D+GG+ I G++L+ W +
Sbjct: 30219 YIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTI 30278
Query: 1492 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSG---RISEIIEAKTHGREPSFSKDQHLF 1548
S + LK Y +++A+N G + E + KT P +
Sbjct: 30279 DSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEV 30338
Query: 1549 THINSTHARLN-LQGWNNGGCPITAIVLEYRPKGT--WAWQGLRANSSGEVFLTELREAT 1605
+ + L+ + ++GG +T +E + T W ++ +T L
Sbjct: 30339 LDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDA 30398
Query: 1606 WYELRMRACNSAG 1618
Y+ R+ A N G
Sbjct: 30399 EYQFRIIAQNDVG 30411
Score = 102 bits (255), Expect = 3e-21
Identities = 246/1143 (21%), Positives = 426/1143 (37%), Gaps = 203/1143 (17%)
Query: 485 FSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYR 544
F L KG P P+V+W ++P+ D + ++ + + V Q D G Y
Sbjct: 20000 FRLKIPIKGKPAPSVSWKKGEDPLATD-----TRVSVESSAVNTTLIVYDCQKSDAGKYT 20054
Query: 545 CTARNLVGSAEYQARINVRGPPSIRA----MRNITAVA-----------GRDTLINCRVI 589
T +N+ G+ E I V G P I +TA A G + N +
Sbjct: 20055 ITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILE 20114
Query: 590 GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSV 649
+ KW A + + T ++T + +GM EY V + + + +
Sbjct: 20115 KRDSVNNKWVTCASAV---------QKTTFRVTRLHEGM---EYTFRVSAENKYGVGE-- 20160
Query: 650 HVAVKVPPLI--QPFEFPPASIGQLLYIPCVVSSGDMPIRITW---RKDGQVIISGSGVT 704
+K P++ PF+ P A P +V + +TW +K G I+G +
Sbjct: 20161 --GLKSEPIVARHPFDVPDAPPP-----PNIVDVRHDSVSLTWTDPKKTGGSPITGYHLE 20213
Query: 705 IESKEF------------MSSLQISSVSLKHNGNYTCIASNAAAT--VSRERQLIVRVPP 750
+ + M +++ ++ + +A N A S + +V + P
Sbjct: 20214 FKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDP 20273
Query: 751 RFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRI---QIL 807
+ P GK V+N + + ++W K G + LTG I + L
Sbjct: 20274 ---IDPP------GKPEVINITRNSV---TLIWTEPKYDGGHK------LTGYIVEKRDL 20315
Query: 808 PNSS-LLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAK 866
P+ S + HV + + + TD+ + +I A T+ A +
Sbjct: 20316 PSKSWMKANHVNVPECAFTV--------TDLVEGGKYEFRIRAKNTA--GAISAPSESTE 20365
Query: 867 ELNCTARGERPIII---------RWEKGDTVI--------DPDRVMRYAIATKD----NG 905
+ C E P I+ + GDT++ P ++ A KD +
Sbjct: 20366 TIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDI 20425
Query: 906 DEVVST-----LKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP-ELEIREVK 959
++ ST L +K A R D+ ++ A N +G +++TV + P PP +EI V
Sbjct: 20426 TQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVS 20485
Query: 960 ARSMNLRWTQRF-DGNSIITGFDIEYKNKSD-SW----DFKQSTRNISPTINQANIVDLH 1013
A L WT DG S I + +E + S W + QS R+++ + Q N
Sbjct: 20486 AEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGN----- 20540
Query: 1014 PASVYSIRMYSFNKIGRSEP-SKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKK 1072
Y R+ + N G+ EP E + P GPP + VT + V+WK P
Sbjct: 20541 ---EYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVD 20597
Query: 1073 ELQNGVIRGYQIGYRENSP-----GSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQ 1127
+ I GY + RE S + K TG L++ + Y V
Sbjct: 20598 D-GGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTG---------LQEGSTYEFRVS 20647
Query: 1128 AFNRAGTGPSSSEINATTLEDV--PSQPPENVRALSITSDVAVISWSEPPRSTLNGV-LK 1184
A NRAG GP S ++ ++D P PP N T A ++W +P G+ +
Sbjct: 20648 AENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYD--GGLEIT 20705
Query: 1185 GYRVIFWSLYVDGEWGEMQNITTTRERV------ELRGMEKFTNYSVQVLAYTQAGDGVR 1238
GY V+ D W +++ T T R+ +L+ EK Y+ ++ A AG G
Sbjct: 20706 GY-VVEHQKVGDEAW--IKDTTGTALRITQFVVPDLQTKEK---YNFRISAINDAGVGEP 20759
Query: 1239 SSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRK-YTIFCSSPGSGQPA 1297
+ + ++ E P + A + V+R +I P G+PA
Sbjct: 20760 AVIPDVEIVEREMAPDFELDA--------------ELRRTLVVRAGLSIRIFVPIKGRPA 20805
Query: 1298 PSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKV-TIE-PAGK----APAK 1351
P T A++ + + L + + R ++ + V TIE PAGK +
Sbjct: 20806 PEVTWTKDNINLKNRANIENTESFTLLI--IPECNRYDTGKFVMTIENPAGKKSGFVNVR 20863
Query: 1352 IISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLR 1411
++ G V D+ ++ P + + + + R ++ T
Sbjct: 20864 VLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVE-KREATRKSYSTATTKCH 20922
Query: 1412 AVKAEDSG-------YYTCTATNTGGF----DTIIVNLLVQVPPDQPRLTVSKTSASSIT 1460
+ +G ++ A N G +T + P L + + S+++
Sbjct: 20923 KCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVS 20982
Query: 1461 LTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKN 1519
L W P +GGS I G+V++ S++W + + + +L G Y ++ A N
Sbjct: 20983 LAWPKPKHDGGSKITGYVIEAQRKGSDQWTHI-TTVKGLECVVRNLTEGEEYTFQVMAVN 21041
Query: 1520 SVG 1522
S G
Sbjct: 21042 SAG 21044
Score = 100 bits (250), Expect = 1e-20
Identities = 174/797 (21%), Positives = 294/797 (36%), Gaps = 113/797 (14%)
Query: 810 SSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELN 869
+SL I+ +ED+G Y SN G+ +TV I ++ P I+ E++
Sbjct: 25450 TSLSIKEASKEDVGTYELCVSNSAGS-------ITVPITIIVLDRPGPPGPIR--IDEVS 25500
Query: 870 CTARGERPIIIRW----------------EKGDTVIDPDRVMRYAIATKDNGDEVVSTLK 913
C + I I W EK +T ++ A+A +++K
Sbjct: 25501 CDS-----ITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVAR--------TSIK 25547
Query: 914 LKPADRGDSVFFSCHAINSYG-----EDRGLIQLTVQEPPDPPEL-EIREVKARSMNLRW 967
+ G F A N YG E ++ PP PP ++ +M + W
Sbjct: 25548 IVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTW 25607
Query: 968 TQRF-DGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFN 1026
DG S + G+ +EYK +S K + I+ T Q + L +Y R+Y+ N
Sbjct: 25608 QVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADT--QMKVSGLDEGLMYEYRVYAEN 25665
Query: 1027 KIGRSEPSKELTISTEEAAPDGPPMDVTLQP----VTSQSIQVTWKAPKKELQNGVIRGY 1082
G + SK E P P D QP +T +S+ + W P + I GY
Sbjct: 25666 IAGIGKCSKSC-----EPVPARDPCDPPGQPEVTNITRKSVSLKWSKPHYD-GGAKITGY 25719
Query: 1083 QIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEIN 1142
+ RE G + + ++ T + + L + +Y V A N A + SE
Sbjct: 25720 IVERRELPDGRWLKCNYTNIQET----YFEVTELTEDQRYEFRVFARNAADSVSEPSEST 25775
Query: 1143 ATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSL-YVDGEWGE 1201
+ +PP + + DV V+ E + + + VI W+ ++ E
Sbjct: 25776 GPIIVKDDVEPPRVMMDVKF-RDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERA 25834
Query: 1202 MQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAG-IKAV 1260
I +T L + + Q + + G RS + + D PGPPAG ++
Sbjct: 25835 RTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVL-DKPGPPAGPLEIN 25893
Query: 1261 PSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQ 1320
+A +SW P + G Y I + A + E + ++ L +G +
Sbjct: 25894 GLTAEKCSLSWGRPQEDGGADIDYYI-VEKRETSHLAWTICEGELQMTSCKVTKLLKGNE 25952
Query: 1321 YLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPA 1380
Y+ V V G G E V I+ TV +P L SV +
Sbjct: 25953 YIFRVTGVNKYGVGEPLESVAIKALDPF---------TVPSP---PTSLEITSVTKESMT 26000
Query: 1381 VKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTG-------GFDT 1433
+ W++ D +S G+ +I LR V+ Y +TG +
Sbjct: 26001 LCWSRPESDGGSEIS--GY-IIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRV 26057
Query: 1434 IIVN-------------------LLVQVPPDQPRLTVSKTSASSITLTWI-PGDNGGSSI 1473
N + + PP +P++ S ++IT+ W+ P +GG+ I
Sbjct: 26058 YAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDS--GKTTITIAWVKPLFDGGAPI 26115
Query: 1474 RGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIE-- 1531
G+ ++Y + +WK S + + L G Y ++ + N VG+ S+ +
Sbjct: 26116 TGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQ 26175
Query: 1532 -AKTHGREPSFSKDQHL 1547
AK EP F D +
Sbjct: 26176 IAKEREEEPLFDIDSEM 26192
Score = 100 bits (250), Expect = 1e-20
Identities = 208/990 (21%), Positives = 356/990 (35%), Gaps = 133/990 (13%)
Query: 705 IESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV------PPRFVVQPNN 758
+++ + +SL I + + +G YT N + S L+V+V P VQ
Sbjct: 26233 VDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLT--LVVKVLDTPGPPTNITVQDVT 26290
Query: 759 QDGIY---------GKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPN 809
++ G A V N ++ K W + N Y
Sbjct: 26291 KESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYK------------- 26337
Query: 810 SSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELN 869
+ ++ E I Y+ N G I VKI T P+ ++L
Sbjct: 26338 ----VTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKI----TEKPSPP-------EKLG 26382
Query: 870 CTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDE-------------VVSTLKLKP 916
T+ + + + W K + R++ Y + + G + VVS L+
Sbjct: 26383 VTSISKDSVSLTWLKPEHD-GGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLR--- 26438
Query: 917 ADRGDSVFFSCHAINSYGEDRG---LIQLTVQEPPDPPELEIREVKARSMNLRWTQRFDG 973
FF A N G L+ + ++E +PPE++++ + ++ +R
Sbjct: 26439 --ENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKV 26496
Query: 974 NSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANI-VDLHPASVYSIRMYSF---NKIG 1029
+ I+G + S ++T + I N+ ++L + Y N G
Sbjct: 26497 DIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRYEITAANSSG 26556
Query: 1030 RSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYREN 1089
++ + + P GP V + +T +S+ + W+ PK + + Y + RE
Sbjct: 26557 TTKAFINIVVLDRPGPPTGP---VVISDITEESVTLKWEPPKYD-GGSQVTNYILLKRET 26612
Query: 1090 SPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATT-LED 1148
S E+ AT + + L +Y ++A NR G T L
Sbjct: 26613 STAV-----WTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPY 26667
Query: 1149 VPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGE----WGEMQN 1204
PP ++T + + W EP NG G V+ + L + W +
Sbjct: 26668 TTPGPPSTPWVTNVTRESITVGWHEP---VSNG---GSAVVGYHLEMKDRNSILWQKANK 26721
Query: 1205 ITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSA 1264
+ ++ + Y +V A AG G S D PP ++ S
Sbjct: 26722 LVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPSEPVLAIDACEPPRNVRITDISK 26781
Query: 1265 SSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLL 1323
+SV +SW P G I Y + G+ + + E F I+ L + QY
Sbjct: 26782 NSVSLSWQQPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFI-ISGLTQNSQYEF 26840
Query: 1324 WVAAVTSAGR-GNSSEKVTIEPAGKAPAKII-SFGGTVT------TPWMK-----DVRLP 1370
V A + G N SE V P I S+GG V T +K V+L
Sbjct: 26841 RVFARNAVGSISNPSEVV-------GPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLR 26893
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAED-----SGYYTCTA 1425
G PAP ++W KD ++ + + L+ T L ++ +D SG Y
Sbjct: 26894 AGISGKPAPTIEWYKDDKE------LQTNALVCVENTTDLASILIKDADRLNSGCYELKL 26947
Query: 1426 TNTGG--FDTIIVNLLVQVPPDQPRLTVSKTSASSITLTW-IPGDNGGSSIRGFVLQYSV 1482
N G TI V +L + P + +A ITL W P D+GG+ I ++++
Sbjct: 26948 RNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRE 27007
Query: 1483 DNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGR--ISEIIEAKTHGREPS 1540
+ W V E + G Y ++ A N G G S+ + AK P
Sbjct: 27008 TSRVVWSMVSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPG 27067
Query: 1541 FSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEV--FL 1598
+ ++ + + +GG I+ LE R K + W + + + +
Sbjct: 27068 PPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKV 27127
Query: 1599 TELREATWYELRMRACNSAGCG--NETAQF 1626
T L E + Y+ R+ A N+AG G +E ++F
Sbjct: 27128 TGLTENSDYQYRVCAVNAAGQGPFSEPSEF 27157
Score = 96.3 bits (238), Expect = 3e-19
Identities = 160/717 (22%), Positives = 274/717 (38%), Gaps = 81/717 (11%)
Query: 946 EPPDPP-ELEIREVKARSMNLRWTQRF-DGNSIITGFDIEYKNKSDSWDFKQSTRNISPT 1003
+PP PP ++++ + +L WT+ DG S I G+ +E + + + + N
Sbjct: 17802 KPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTA---QWNRINKDEL 17858
Query: 1004 INQA--NIVDLHPASVYSIRMYSFNKIGRSEPSK--ELTISTEEAAPDGPPMDVTLQPVT 1059
I Q + L + Y R+ + N +G EP + E I+ + P +DVT + V
Sbjct: 17859 IRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVI 17918
Query: 1060 SQSI----------------QVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMK 1103
+ + +TW K L +R ++ ++ P VE++
Sbjct: 17919 TVRVGQTIRILARVKGRPEPDITWTKEGKVL----VREKRVDLIQDLPR-------VELQ 17967
Query: 1104 ATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSIT 1163
E D+ K ++ A N +G S+ +N D P P +N++ ++T
Sbjct: 17968 I---KEAVRADHGK------YIISAKNSSGHAQGSAIVNVL---DRPG-PCQNLKVTNVT 18014
Query: 1164 SDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNY 1223
+ ISW E P + + V + G W + + T +R+ + Y
Sbjct: 18015 KENCTISW-ENPLDNGGSEITNFIVEYRKPNQKG-WSIVASDVT--KRLIKANLLANNEY 18070
Query: 1224 SVQVLAYTQAGDG----VRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNG 1279
+V A + G G ++ +L I D PG P + + V + W P G
Sbjct: 18071 YFRVCAENKVGVGPTIETKTPILAINPI-DRPGEPENLHIADKGKTFVYLKWRRPDYDGG 18129
Query: 1280 VIR-KYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGN--S 1336
Y + GS ++ S ++ Y + Q Y V G +
Sbjct: 18130 SPNLSYHVERRLKGSDD-WERVHKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVK 18188
Query: 1337 SEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSM 1396
+E+V ++ + P + G +T +RL G P P V WTKD + A ++
Sbjct: 18189 TEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKD--ATDLTR 18246
Query: 1397 DGHRLIHT---NGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR-LTVS 1452
I T + L K D G Y TATNT G + V P R L +
Sbjct: 18247 SPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIV 18306
Query: 1453 KTSASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWY 1511
S+ T+ W P D+GG I+ ++L+ W + + L G Y
Sbjct: 18307 DVSSDRCTVCWDPPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEY 18366
Query: 1512 KVKLAAKNSVGSGRISEI--IEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWN----N 1565
++ A+N +G+G +E + AKT +P D T ++ + WN +
Sbjct: 18367 IFRVRAENKIGTGPPTESKPVIAKTKYDKPG-RPDPPEVTKVSKEEMTV---VWNPPEYD 18422
Query: 1566 GGCPITAIVLEYRPKGTWAWQGLRANSSGE--VFLTELREATWYELRMRACNSAGCG 1620
GG IT LE + K + W + ++ E + + L Y+ R++A N G G
Sbjct: 18423 GGKSITGYFLEKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIG 18479
Score = 96.3 bits (238), Expect = 3e-19
Identities = 270/1357 (19%), Positives = 470/1357 (34%), Gaps = 246/1357 (18%)
Query: 394 LSCALTGSPEFTIRWYRNTELVLPDEAISIRGLS-NETLLITSAQKSHSGAYQCFATRKA 452
L + G P ++ W + + + D +S+ + N TL++ QKS +G Y A
Sbjct: 20002 LKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVA 20061
Query: 453 QTAQDFAIIAL--EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVR 510
T + I + + G P F E A T+ WA P
Sbjct: 20062 GTKEGTISIKVVGKPGIPTGPIKFDEVT---------------AEAMTLKWA----PPKD 20102
Query: 511 DGSHRTNQYTMSDGTTISHMNVTGP-----------QIRDGGVY--RCTARNLVGSAE-- 555
DG Y + ++++ VT ++ +G Y R +A N G E
Sbjct: 20103 DGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGL 20162
Query: 556 YQARINVRGP---PSIRAMRNITAVAGRDTLINC----RVIGYPY--YSIKWYKDALLLP 606
I R P P NI V + + G P Y +++ + LL
Sbjct: 20163 KSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLW 20222
Query: 607 DNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPP 666
+ K+T + +G++ + ++ + S V + P+ P +
Sbjct: 20223 KRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGK--- 20279
Query: 667 ASIGQLLYIPCVVSSGDMPIRITWRK---DGQVIISGSGVT---IESKEFMSSLQISS-- 718
P V++ + + W + DG ++G V + SK +M + ++
Sbjct: 20280 ---------PEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPE 20330
Query: 719 -----VSLKHNGNYT--CIASNAAATVSRERQLIVRV-------PPRFVVQPNNQDGIYG 764
L G Y A N A +S + + P V+ P +DG+
Sbjct: 20331 CAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTI 20390
Query: 765 KAG---VLNC-SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLL-IRHVLE 819
KAG VLN S+ G P PK W A P + T P SS+L I++
Sbjct: 20391 KAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITST------PTSSMLTIKYATR 20444
Query: 820 EDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPII 879
+D G Y A+N GT + VK+ + P + I + E T P+
Sbjct: 20445 KDAGEYTITATNPFGTKVEH-----VKVTVLDVPGPPGPVEISNVSAE-KATLTWTPPL- 20497
Query: 880 IRWEKGDTVI--------DPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAIN 931
E G + I + R++ ++ V+T ++ G+ F A+N
Sbjct: 20498 ---EDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQ----GNEYIFRVSAVN 20550
Query: 932 SYGEDRGLIQLTVQE-----PPDPPEL-EIREVKARSMNLRWTQRFD-GNSIITGFDIEY 984
YG+ + V+ PP PPE E+ V + + W + D G S ITG+ +E
Sbjct: 20551 HYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVER 20610
Query: 985 KNKSD-SWDFKQSTRNISPTIN--QANIVDLHPASVYSIRMYSFNKIGRSEPSK--ELTI 1039
+ K W R I ++ + + L S Y R+ + N+ G PS+ + +
Sbjct: 20611 REKKSLRW-----VRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVL 20665
Query: 1040 STEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK----KELQNGVIRGYQIGYRENSPGSNG 1095
+ A P GPP + + T +S + W P E+ V+ ++G + G
Sbjct: 20666 MKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTG 20725
Query: 1096 QYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPE 1155
++ T + + +L+ +Y + A N AG G
Sbjct: 20726 ----TALRIT----QFVVPDLQTKEKYNFRISAINDAGVGEP------------------ 20759
Query: 1156 NVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSL----YVDGEWGEMQNITTTRER 1211
++ DV ++ P L+ L+ V+ L +V + +T T++
Sbjct: 20760 -----AVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDN 20814
Query: 1212 VELR---GMEKFTNYSVQVLAYTQAGD------------GVRSSVLYIQTKEDVPGPPAG 1256
+ L+ +E ++++ ++ D G +S + ++ D PGP
Sbjct: 20815 INLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVL-DTPGPVLN 20873
Query: 1257 IKAVPSSASSVVVSW-LPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHL 1315
++ + SV + W LP I Y + + + + S T + Y++ L
Sbjct: 20874 LRPTDITKDSVTLHWDLPLIDGGSRITNYIV--EKREATRKSYSTATTKCHKCTYKVTGL 20931
Query: 1316 NRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVG 1375
+ G +Y V A G G +E A +AP+ S + D+ S+
Sbjct: 20932 SEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLN-------IMDITKSTVSLA 20984
Query: 1376 DPAPAVKWTKDSEDSAIPVSMDG-----HRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
P P I G H ++R + + + A N+ G
Sbjct: 20985 WPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAG 21044
Query: 1431 FDT----------------------IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDN 1468
I L++ D ++ + T+TW GD
Sbjct: 21045 RSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQ 21104
Query: 1469 GGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISE 1528
+ Q N E I + + DS G + L A+N V G + +
Sbjct: 21105 -------ILKQTQRVNFETTATSTILNINECVRSDS---GPY---PLTARNIV--GEVGD 21149
Query: 1529 IIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGW----NNGGCPITAIVLEYRPKGTWA 1584
+I + H P F ++S + W N+GG PI+ V+E R +
Sbjct: 21150 VITIQVHD-IPGPPTGPIKFDEVSSDFVTFS---WDPPENDGGVPISNYVVEMRQTDSTT 21205
Query: 1585 WQGLRANSSGEVF-LTELREATWYELRMRACNSAGCG 1620
W L + T L Y+ R++A N G G
Sbjct: 21206 WVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVG 21242
Score = 94.7 bits (234), Expect = 8e-19
Identities = 205/965 (21%), Positives = 355/965 (36%), Gaps = 138/965 (14%)
Query: 465 DGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDG 524
D P I + +V GE+ S+ + P PTV+W D + + +++ TM +
Sbjct: 14384 DCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEV-----KASDRLTMKND 14438
Query: 525 TTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLI 584
+H+ V D G+Y T N +GSA + V G P ++I A T
Sbjct: 14439 HISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLPG--PCKDIKA--SDITKS 14494
Query: 585 NCRVIGYPYY-----SIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGM-DEGEYLCSVL 638
+C++ P I Y + +G KL+ K + GEY V
Sbjct: 14495 SCKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRV- 14553
Query: 639 IQPQLSISQSVHVAVKVPPLIQ-PFEFPPASIGQLLYIPCVVSSGDMPIRITWRK---DG 694
+ + ++ +K P + Q P + P + ++ P + + ITW+ DG
Sbjct: 14554 -KAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEA-----MTITWKPPLYDG 14607
Query: 695 QVIISGSGVTIESK----------EFMSSLQISSVSLKHNGNYT--CIASNAAATVSRER 742
I G + +K + L ++ L+ Y A NAA R
Sbjct: 14608 GSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSR 14667
Query: 743 QLIVRVPPRFVVQPNNQDGIY---------GKAGVLNCSVDGYPPPKVMW---------- 783
PP V P + + G L+ S+ G P P + W
Sbjct: 14668 A----TPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPE 14723
Query: 784 ----------KHAKGSGNPQQYHPVPLTGRIQI----LPNSSLLIRHVLEEDIGYYLCQA 829
+ KG ++ +PLT R+ I S L +R L D G Y+ +
Sbjct: 14724 EIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKV 14783
Query: 830 SNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEK----- 884
N G K P ++ I +++ T+ ++ +WE
Sbjct: 14784 ENDHGI---------AKAPCTVSVLDTPGPPINFVFEDIRKTS-----VLCKWEPPLDDG 14829
Query: 885 GDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPAD-------RGDSVFFSCHAINSYGE-- 935
G +I+ + TK + + +V T L+ G F A N +G
Sbjct: 14830 GSEIIN--YTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGP 14887
Query: 936 ---DRGLIQLTVQEPPDPPELEIRE-VKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSW 991
+ L+ PPD P+ I E V + SM ++W + D S I G+ +E K + +S
Sbjct: 14888 PCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGSPILGYWLE-KREVNST 14946
Query: 992 DFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIG--RSEPSKELTISTEEAAPDGP 1049
+ + +++ + +AN+ L Y R+ + N G + P + + + +P GP
Sbjct: 14947 HWSRVNKSLLNAL-KANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGP 15005
Query: 1050 PMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSE 1109
P+ + +S +I++ W+ P G I GY + + G+N E
Sbjct: 15006 PIP-RVTDTSSTTIELEWEPPAFN-GGGEIVGYFVD--KQLVGTNEWSRCTEKMIK--VR 15059
Query: 1110 VYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVI 1169
YT+ +++ A Y + V A N AG GP T E P +PP +S+ + ++
Sbjct: 15060 QYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAE--PQEPPAVELDVSVKGGIQIM 15117
Query: 1170 SWSEPPRSTLNGVLKGYRV--IFWSL---YVDGEWGEMQNITTTRERVELRGMEKFTNYS 1224
+ + V+ G V W+ +D + + N+ T E + + K
Sbjct: 15118 AGK---TLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRY 15174
Query: 1225 VQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKY 1284
V + A G ++ + + DVPGP +K V ++ +++W P G +
Sbjct: 15175 V-ITATNSCGSKFAAARVEV---FDVPGPVLDLKPVVTNRKMCLLNWSDPEDDGG--SEI 15228
Query: 1285 TIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE---KVT 1341
T F + E+ I L GQ+Y V A G G E +
Sbjct: 15229 TGFIIERKDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILA 15288
Query: 1342 IEPAG 1346
++P G
Sbjct: 15289 VDPLG 15293
Score = 94.7 bits (234), Expect = 8e-19
Identities = 269/1166 (23%), Positives = 427/1166 (36%), Gaps = 203/1166 (17%)
Query: 319 WLKDGRPLPADSRWTKRI------TGLTISDLRTEDSGTYICEVTNTFGS----AEATGI 368
++ + R LP D RWTK T IS L + N GS +E G
Sbjct: 26802 YIVERRDLP-DGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGP 26860
Query: 369 LMVID---------PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDE 419
+ ID PL T + +K G++V L ++G P TI WY++ + + +
Sbjct: 26861 ITCIDSYGGPVIDLPLEYT---EVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNA 26917
Query: 420 AISIRGLSN-ETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKV 478
+ + ++ ++LI A + +SG Y+ K + A A T R+ +K
Sbjct: 26918 LVCVENTTDLASILIKDADRLNSGCYEL----KLRNAMGSA-----SATIRV--QILDKP 26966
Query: 479 VNPGE--QFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTT---------- 526
PG +F + A K T+ W P DG + Y + T
Sbjct: 26967 GPPGGPIEFKTVTAEK----ITLLW----RPPADDGGAKITHYIVEKRETSRVVWSMVSE 27018
Query: 527 -ISHMNVTGPQIRDGG--VYRCTARNLVGSAEYQARINV--------RGPPSIRAMRNIT 575
+ +T +I G ++R A N G E +V GPP I + IT
Sbjct: 27019 HLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKIT 27078
Query: 576 AVAGRDTLINCRVI--------GY-----PYYSIKWYKDALLLPDNHRQVVFENGTLKLT 622
T++ R I GY S+ W+K +L + R K+T
Sbjct: 27079 --KNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFK---VLKETIRDT-----RQKVT 27128
Query: 623 DVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSG 682
+ + D +C+V Q S+ P+ P PPA I + S
Sbjct: 27129 GLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPP--GPPAKIR-------IADST 27179
Query: 683 DMPIRITWRK---DGQVIISGSGV-----------TIESKEFMSSLQISSVSLKHNGNY- 727
I + W K DG ++G V T+ +K + + + +LK NY
Sbjct: 27180 KSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYY 27239
Query: 728 ------TCIASNAAATVSRERQL-IVRVPPRFVVQPNNQDGIYGKAG---VLNCSVDGYP 777
C ++ Q + P + + + KAG + G P
Sbjct: 27240 FRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRP 27299
Query: 778 PPKVMW-KHAKGSGNPQQYHPVPLTGRIQILPNSSLL-IRHVLEEDIGYYLCQASNGVGT 835
PP V W K K G+ +Y I+ +SSLL I V D G Y+ NGVG
Sbjct: 27300 PPTVTWRKDEKNLGSDARY-------SIENTDSSSLLTIPQVTRNDTGKYILTIENGVGE 27352
Query: 836 DISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVM 895
S TV + + T + +K H T + P+I + G +I + V+
Sbjct: 27353 PKSS----TVSVKVLDTPAACQKLQVK-HVSRGTVTLLWDPPLI---DGGSPII--NYVI 27402
Query: 896 RYAIATKDNGDEV-----VSTLKLKPADRGDSVFFSCHAINSYG---EDRGLIQLTVQEP 947
ATK V ++ KL FF A N G + E
Sbjct: 27403 EKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEV 27462
Query: 948 PDP-PELEIREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNKSD-SWDFKQSTRNISPTI 1004
P P +L +++ S+ L WT+ FDG S+IT + +E K K + +W S IS T
Sbjct: 27463 PAPIRDLSMKDSTKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTW----SHAGISKTC 27518
Query: 1005 NQANIVDLHPASVYSIRMYSFNKIGRSEP-------SKELTISTEEAAPDGPPMDVTLQP 1057
+ + L SV R+++ N+ G S+P KEL I+ E D P VT++
Sbjct: 27519 -EIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRI 27577
Query: 1058 VTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLK 1117
+ +++ +K K + + G + E V T + ++ N K
Sbjct: 27578 GHNVHLELPYKGKPKPSISWLKDGLPLKESE----------FVRFSKTENKITLSIKNAK 27627
Query: 1118 KFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRS 1177
K ++G + I TL PS+P +R I +D ++SW P
Sbjct: 27628 K--EHGGKYTVILDNAVCRIAVPITVITL-GPPSKPKGPIRFDEIKADSVILSWDVPED- 27683
Query: 1178 TLNGVLKGYRVIFWSL----YVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQA 1233
NG G + +S+ W +M + R ++ + K Y +V A +
Sbjct: 27684 --NG---GGEITCYSIEKRETSQTNW-KMVCSSVARTTFKVPNLVKDAEYQFRVRAENRY 27737
Query: 1234 G--DGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIF-CSS 1290
G + SS++ + + +PGPP ++ + ++W P G + T F
Sbjct: 27738 GVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSLTWDAPVYDGG--SEVTGFHVEK 27795
Query: 1291 PGSGQPAPSEYETSP-EQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE--KVT-----I 1342
+ TSP YR L G Y V A SAG + S+ K T +
Sbjct: 27796 KERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPV 27855
Query: 1343 EPAGKAPAKIISFGGTVTTPWMKDVR 1368
+P G P I T+T W +R
Sbjct: 27856 DPPG-TPDYIDVTRETITLKWNPPLR 27880
Score = 92.8 bits (229), Expect = 3e-18
Identities = 249/1140 (21%), Positives = 421/1140 (36%), Gaps = 189/1140 (16%)
Query: 487 LMCAAKGAPPPTVTWALDD-EPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRC 545
L KG P P V WA D E + + T+ YT+ ++ D G Y
Sbjct: 21880 LFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTLLIVGNVNRF--------DSGKYIL 21931
Query: 546 TARNLVGSAEYQARINVR-----GPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWY- 599
T N GS A +NVR GPP ++ +T + T + G IK Y
Sbjct: 21932 TVENSSGSKS--AFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGS--KIKNYI 21987
Query: 600 ---KDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVP 656
+++ + + K+ +Q+G Y VL + + I A V
Sbjct: 21988 VEKRESTRKAYSTVATNCHKTSWKVDQLQEGCS---YYFRVLAENEYGIGLPAETAESVK 22044
Query: 657 PLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRK---DGQVIISGSGVTIESKEF--- 710
+P PP G++ + +S + ++W K DG I G V +++K
Sbjct: 22045 ASERPL--PP---GKITLMDVTRNS----VSLSWEKPEHDGGSRILGYIVEMQTKGSDKW 22095
Query: 711 -------MSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV-------PPRFVVQP 756
++ I+ + ++ A N +S RQL V V PP F +
Sbjct: 22096 ATCATVKVTEATITGLIQGEEYSFRVSAQNEKG-ISDPRQLSVPVIAKDLVIPPAFKLLF 22154
Query: 757 NNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILP---NSSLL 813
N + G+ ++ G P P V W + P+ T R+ NS L
Sbjct: 22155 NTFTVLAGEDLKVDVPFIGRPTPAVTWH--------KDNVPLKQTTRVNAESTENNSLLT 22206
Query: 814 IRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTAR 873
I+ ED+G+Y+ + +N G I + + P T G K TA
Sbjct: 22207 IKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPT----------GPVKMDEVTAD 22256
Query: 874 GERPIIIRWEKGDTVID-PDRVMRYAIATKDNGD---EVVS------TLKLKPADRGDSV 923
I + W G D + Y + +D ++VS T+K G
Sbjct: 22257 S---ITLSW--GPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEY 22311
Query: 924 FFSCHAINSYGEDRGLIQ--LTVQEP---PDPPELEIREVKAR-SMNLRWTQRF-DGNSI 976
F A N YG+ L Q P P PP + + +R SM ++W + DG S
Sbjct: 22312 QFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSR 22371
Query: 977 ITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSK- 1035
+ G+ +E K ++ K + I T + L Y R+ + N +G +PSK
Sbjct: 22372 VIGYHLERKERNSILWVKLNKTPIPQT--KFKTTGLEEGVEYEFRVSAENIVGIGKPSKV 22429
Query: 1036 -ELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSN 1094
E ++ + P G P + VT S+ + WK P + I GY + +E G
Sbjct: 22430 SECYVARDPCDPPGRPEAII---VTRNSVTLQWKKPTYD-GGSKITGYIVEKKELPEGRW 22485
Query: 1095 GQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPP 1154
+ S + T + + L + +Y V A N AG V S+P
Sbjct: 22486 MKASFTNIIDTH----FEVTGLVEDHRYEFRVIARNAAG---------------VFSEPS 22526
Query: 1155 ENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIF--WSLYVDG----------EWGEM 1202
E+ A++ +V +PPR +++ K V+ S VD +W +
Sbjct: 22527 ESTGAITARDEV------DPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKG 22580
Query: 1203 QNITTTRERVELRGMEKFTNYSVQVLAYTQAGD---------GVRSSVLYIQTKEDVPGP 1253
+ R+E++ + T+ SV+ +G+ G RS + ++ D PGP
Sbjct: 22581 DQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVL-DRPGP 22639
Query: 1254 PAGIKAVPS-SASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYR 1311
P G + +A ++W PP + G I Y + + + + + + + L +
Sbjct: 22640 PEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIV--ERRETSRLVWTVVDANVQTLSCK 22697
Query: 1312 IAHLNRGQQYLLWVAAVTSAGRGNSSEK--------VTIEPAGKAPAKIISFGGTVTTPW 1363
+ L G +Y + AV G G E + A KAP ++ W
Sbjct: 22698 VTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVW 22757
Query: 1364 MKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAV-KAEDSGY-Y 1421
+ P + G K ++ I + RLI G L LR E+ Y +
Sbjct: 22758 ER----PASDGGSEILGYVLEKRDKE-GIRWTRCHKRLI---GELRLRVTGLIENHDYEF 22809
Query: 1422 TCTATNTGG---------FDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWI-PGDNGGS 1471
+A N G + + PP+ P+ V + SS+ L+W P +GG
Sbjct: 22810 RVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPK--VIDITRSSVFLSWSKPIYDGGC 22867
Query: 1472 SIRGFVLQYSVDNSEEWKDVF--ISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEI 1529
I+G++++ + EW ++ + +++ L Y ++ A N G G +++
Sbjct: 22868 EIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADV 22927
Score = 91.7 bits (226), Expect = 7e-18
Identities = 196/934 (20%), Positives = 336/934 (35%), Gaps = 124/934 (13%)
Query: 92 LQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSA 151
L+ V + + VV C +GS ++ WY G + D P+++ + T L F
Sbjct: 8063 LRDVQETVGLPVVFDCAISGSEPISVSWY-KDGKPLKDSPNVQTSFLDNTATLNIFKTDR 8121
Query: 152 FNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREP--YTVRVEDQRSMRGNVAVFKCLIP 209
+ Y CTA N G S + + P + +R+ ++ G A F+C +
Sbjct: 8122 SLA----GQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVT 8177
Query: 210 SSVQEYVSVVSWEKDTVSIIPEHRFFITY---HGGLYISDVQKEDALSTYRCITKHKYSG 266
+ VSW KD+ I ++ I+Y L + V K D+ Y C ++
Sbjct: 8178 GTQP---IKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDS-GQYTCYAVNEVG- 8232
Query: 267 ETRQSNGARLSVTDPAESIPTILDGFHSQEV--WAGHTVELPCTASGYPIPAIRWLKDGR 324
+ S A+L++ + IP S+ V G++ +L +G + W K+
Sbjct: 8233 --KDSCTAQLNIKE--RLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNI 8288
Query: 325 PLPADSR----WTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDP-----L 375
+ S + L + D+G Y C+V+N GSA T +++ +P
Sbjct: 8289 EIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVF 8348
Query: 376 HVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLL-IT 434
LTP + G V LSC + GS I+W + + P + S S +L +
Sbjct: 8349 DQHLTPVTVSEG--EYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELR 8406
Query: 435 SAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQF--------- 485
K+ SG Y C A+ A + + + ++D V+ ++K G F
Sbjct: 8407 DVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPA--VAPATKKAAVDGRLFFVSEPQSIR 8464
Query: 486 -------SLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIR 538
+ + G P P V W + G R + D + + T
Sbjct: 8465 VVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGG-RVFIHQKGDEAKLEIRDTTKT--- 8520
Query: 539 DGGVYRCTARNLVGSAEYQARINV-------RGPPSIRAMRNITAV----AGRDTLINC- 586
D G+YRC A N G E + V + +RAM T + AG + I+
Sbjct: 8521 DSGLYRCVAFNEHGEIESNVNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIM 8580
Query: 587 ----RVIGYPY------YSIKWYKDAL----LLPDNHRQVVFENGTLKLTDVQKG-MDEG 631
V Y Y I ++ L LL + + E L++ ++++ DE
Sbjct: 8581 ELLKNVDPKEYEKYARMYGITDFRGLLQAFELLKQSQEE---ETHRLEIEEIERSERDEK 8637
Query: 632 EYLCSV-LIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITW 690
E+ V IQ +LS ++ V LI+ E + I+++W
Sbjct: 8638 EFEELVSFIQQRLSQTEPV-------TLIKDIENQTVLKDNDAVFEIDIKINYPEIKLSW 8690
Query: 691 RKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPP 750
K + + I +L++ + LK GNY + A+ + + P
Sbjct: 8691 YKGTEKLEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRLVCGPHIASAK-----LTVIEP 8745
Query: 751 RFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNS 810
+ + G+ + C P K W PQ H + ++
Sbjct: 8746 AWERHLQDVTLKEGQTCTMTCQF-SVPNVKSEWFRNGRILKPQGRHKTEVEHKVH----- 8799
Query: 811 SLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI-PAMITSHPNTTIAIKGHAKELN 869
L I V ED G Y C+ D+ S L ++ P T + + +
Sbjct: 8800 KLTIADVRAEDQGQYTCKYE-----DLETSAELRIEAEPIQFTKRIQNIVVSEHQSATFE 8854
Query: 870 CTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHA 929
C + I+ W KG T + + + D ++ + P D G V+
Sbjct: 8855 CEVSFD-DAIVTWYKGPTELTESQKYNF---RNDGRCHYMTIHNVTPDDEG--VYSVIAR 8908
Query: 930 INSYGEDRGL--IQLTVQE------PPDPPELEI 955
+ GE R + LT +E PPD P+ +
Sbjct: 8909 LEPRGEARSTAELYLTTKEIKLELKPPDIPDSRV 8942
Score = 89.7 bits (221), Expect = 3e-17
Identities = 160/705 (22%), Positives = 270/705 (38%), Gaps = 83/705 (11%)
Query: 863 GHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDS 922
G A +L+C G I+W + + R +Y K + D TL + ++ D
Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSR--KY----KMSSDGRTHTLTVMTEEQEDE 30600
Query: 923 VFFSCHAINSYGE----DRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRFDGNSI-- 976
++C A N GE + L+Q T Q P P L+ + A LR + G +
Sbjct: 30601 GVYTCIATNEVGEVETSSKLLLQATPQFHPGYP-LKEKYYGAVGSTLRLHVMYIGRPVPA 30659
Query: 977 ITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKE 1036
+T F + ++ ++T + + + + N+ A Y +++ N G + +
Sbjct: 30660 MTWFHGQKLLQNSENITIENTEHYTHLVMK-NVQRKTHAGKYKVQLS--NVFGTVDAILD 30716
Query: 1037 LTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQ 1096
+ I + P GP + ++ + S ++WK P + I Y + E G+ Q
Sbjct: 30717 VEIQDKPDKPTGP---IVIEALLKNSAVISWKPPADD-GGSWITNYVVEKCEAKEGAEWQ 30772
Query: 1097 YSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQP--P 1154
+ T + NL + A Y V A N G + ++ +P P
Sbjct: 30773 LVSSAISVT----TCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAP 30828
Query: 1155 ENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDG-EWGEMQNITTTRERVE 1213
++T D V++W +PP S ++ Y Y++ E + + I+ T E +
Sbjct: 30829 GKPTITAVTKDSCVVAW-KPPASDGGAKIRNY-------YLEKREKKQNKWISVTTEEIR 30880
Query: 1214 -----LRGMEKFTNYSVQVLAYTQAGDGVRSSVLY-IQTKEDVPGPPAGIKAVPSSASSV 1267
++ + + Y +V G+ S + I K DVP K + +
Sbjct: 30881 ETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVR 30940
Query: 1268 VVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPE----QLFYRIAHLNRGQQYLL 1323
S T+ C G +P Y E L YRI G L+
Sbjct: 30941 YQS------------NATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLI 30988
Query: 1324 WVAAVTS---------AGRGNSSEKVTIEPAGKAPAKI-----ISFGGTVTTPWMKDVRL 1369
+A+VT A S T + PAKI + G V + V +
Sbjct: 30989 -IASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSI 31047
Query: 1370 PCNSVGDPAPAVKWTKDSEDSAIPVSMDGH-RLIHTNGTLLL---RAVKAEDSGYYTCTA 1425
G P P + W K + + +GH ++I T L V+ +D+G+Y A
Sbjct: 31048 KIPFSGKPDPVITWQKGQD----LIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCA 31103
Query: 1426 TNTGGFDTIIVNLLVQVPPDQPR-LTVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVD 1483
N G D V L V PD PR + VS S S+ LTW P +GGS I ++++
Sbjct: 31104 KNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCAT 31163
Query: 1484 NSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISE 1528
+E W V + E + + +L T Y+ ++ A+N G + SE
Sbjct: 31164 TAERWLRVG-QARETRYTVINLFGKTSYQFRVIAENKFGLSKPSE 31207
Score = 89.0 bits (219), Expect = 5e-17
Identities = 244/1152 (21%), Positives = 410/1152 (35%), Gaps = 186/1152 (16%)
Query: 478 VVNPGEQFSLMCAAKGAPPPTVTWALDDEPI-VRDGSHRTNQYTMSDGTTISHMNVTGPQ 536
VV G L A +G P PT W+ D + +R H T+ + S + V
Sbjct: 28368 VVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSF--------STLTVENCN 28419
Query: 537 IRDGGVYRCTARNLVGSAEYQARINVR---GPPSIRAMRNITAVAGRDTLINCRVIGYPY 593
D G Y T N GS + V GPP +++T G TL+
Sbjct: 28420 RNDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTR--GSATLM--------- 28468
Query: 594 YSIKWYKDALLLPDNHR----------------QVVFENGTLKLTDVQKGMDEGEYLCSV 637
W DA LL R QV+ E T ++ V + Y V
Sbjct: 28469 ----W--DAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRV 28522
Query: 638 LIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRK---DG 694
+ + + + + QP PP + VV + + W K DG
Sbjct: 28523 SAVNEYGVGEPYEMPEPIVATEQPA--PPRRLD-------VVDTSKSSAVLAWLKPDHDG 28573
Query: 695 QVIISGSGVTIESK------EFMSSLQIS--------------SVSLKHNGNYTCIASNA 734
I+G + + K E + Q++ V K++ Y+
Sbjct: 28574 GSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAF 28633
Query: 735 AATVSRERQLIVRVPPRFVVQPNNQDGIYGKAG---VLNCSVDGYPPPKVMWKHAKGSGN 791
++ + +E Q+ P + NQ I KAG ++ + G P PKV WK
Sbjct: 28634 SSVIIKEPQI---EPTADLTGITNQL-ITCKAGSPFTIDVPISGRPAPKVTWK------- 28682
Query: 792 PQQYHPVPLTGRIQIL---PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIP 848
+ + T R+ I ++L ++ + D G Y N G + + P
Sbjct: 28683 -LEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRP 28741
Query: 849 AMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGD-- 906
+T I + + E + GE + G T + Y + +++G
Sbjct: 28742 GPVTG----PIEVSSVSAESCVLSWGEPK-----DGGGT-----EITNYIVEKRESGTTA 28787
Query: 907 -EVVST------LKLKPADRGDSVFFSCHAINSYGEDRGL--IQLTVQEPPDPPEL---- 953
++V++ +K+ + F + N +G + L + + P PP
Sbjct: 28788 WQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRP 28847
Query: 954 EIREVKARSMNLRWTQRF-DGNSIITGFDIEYKNKSDSWDFKQSTRNISPTIN-QANIVD 1011
E+ V A +M++RW + + DG S I G+ +E K ++ K+ N P + +
Sbjct: 28848 EVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKE---NKVPCLECNYKVTG 28904
Query: 1012 LHPASVYSIRMYSFNKIG---RSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWK 1068
L Y R Y+ N G SE S+ + AP P +VT VT ++ + W
Sbjct: 28905 LVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRP--EVT--DVTRSTVSLIWS 28960
Query: 1069 APKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQA 1128
AP + + V+ GY I + S +G++ D+ +T+ L + Y V A
Sbjct: 28961 APAYDGGSKVV-GYIIERKPVSEVGDGRWLKCNYTIVSDN-FFTVTALSEGDTYEFRVLA 29018
Query: 1129 FNRAGTGPSSSE-INATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYR 1187
N AG SE T D + P + A V + + S+ G +
Sbjct: 29019 KNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPK 29078
Query: 1188 VIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTK 1247
+I+ + + E ++ T +R + KF + S + + + + K
Sbjct: 29079 IIWTKGDKELDLCEKVSLQYTGKRA--TAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVK 29136
Query: 1248 E-DVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSP 1305
D PGP + + ++W P + G I Y + E E
Sbjct: 29137 VLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGEC-- 29194
Query: 1306 EQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE--------KVTIEPAGKAPAKIISFGG 1357
L Y + L + +Y+ V AV G G E TI P ++ +
Sbjct: 29195 PTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKE 29254
Query: 1358 TVTTPWMKDVRLPCNSVGD------PAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLR 1411
+ W K N + + +++WT+ ++D + T L
Sbjct: 29255 HIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVV------------YDTRLKV 29302
Query: 1412 AVKAEDSGY-YTCTATNTGG---------FDTIIVNLLVQVPPDQPRLTVSKTSASSITL 1461
E Y + TA N G F + PP PR V T+ SI+L
Sbjct: 29303 TSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPR--VVDTTKHSISL 29360
Query: 1462 TWI-PGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERS--FKLDSLKCGTWYKVKLAAK 1518
W P +GG+ I G+VL+ ++++W V +++ R+ F + LK G Y ++AA
Sbjct: 29361 AWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAV 29420
Query: 1519 NSVGSGRISEII 1530
N G SE I
Sbjct: 29421 NVKGMSEYSESI 29432
Score = 89.0 bits (219), Expect = 5e-17
Identities = 140/612 (22%), Positives = 236/612 (38%), Gaps = 83/612 (13%)
Query: 1053 VTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGS----NGQYSIVEMKATGDS 1108
+ + V+++S ++W PK + I Y + RE+ + N ++K T
Sbjct: 28748 IEVSSVSAESCVLSWGEPK-DGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVT--- 28803
Query: 1109 EVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINATTLEDVPSQPPENVRALSITSDVA 1167
+L K+ +Y V + NR G P S VP P ++++
Sbjct: 28804 ------HLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAM 28857
Query: 1168 VISWSEPPRSTLNGVLKGYRVI-FWSLYVDGE---WGEMQNITTTRERVELRGMEKFTNY 1223
I W EP G ++I +W + W + + ++ G+ + Y
Sbjct: 28858 SIRWEEPYHDG------GSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEY 28911
Query: 1224 SVQVLAYTQAGDGVRSSV---LYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNG- 1279
+ A AG S + Q D PG P + + S+V + W P G
Sbjct: 28912 QFRTYALNAAGVSKASEASRPIMAQNPVDAPGRP---EVTDVTRSTVSLIWSAPAYDGGS 28968
Query: 1280 -----VIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAG-- 1332
+I + + S G G+ Y T F+ + L+ G Y V A +AG
Sbjct: 28969 KVVGYIIERKPV--SEVGDGRWLKCNY-TIVSDNFFTVTALSEGDTYEFRVLAKNAAGVI 29025
Query: 1333 --RGNSSEKVTIE-----PAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTK 1385
S+ VT P + A++ G VT D+ L G P P + WTK
Sbjct: 29026 SKGSESTGPVTCRDEYAPPKAELDARL--HGDLVTIRAGSDLVLDAAVGGKPEPKIIWTK 29083
Query: 1386 DSED----SAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQ 1441
++ + + G R T +++ DSG YT T N G T V+++V+
Sbjct: 29084 GDKELDLCEKVSLQYTGKR-----ATAVIKFCDRSDSGKYTLTVKNASG--TKAVSVMVK 29136
Query: 1442 V---PPDQPRLTVSKTSASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSE 1497
V P +LTVS+ + TL W +P ++GG+ I ++++ + W V
Sbjct: 29137 VLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPT 29196
Query: 1498 RSFKLDSLKCGTWYKVKLAAKNSVGSG--RISEIIEAKTHGREPSFSKDQHLFTHINSTH 1555
S+ + L Y ++ A N G G SE I A+ PS + + +
Sbjct: 29197 LSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPS---PPGIPEEVGTGK 29253
Query: 1556 ARLNLQGW----NNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVF-----LTELREATW 1606
+ +Q W ++GG I+ +++ R K + W R N V+ +T L E
Sbjct: 29254 EHIIIQ-WTKPESDGGNEISNYLVDKREKKSLRW--TRVNKDYVVYDTRLKVTSLMEGCD 29310
Query: 1607 YELRMRACNSAG 1618
Y+ R+ A N+AG
Sbjct: 29311 YQFRVTAVNAAG 29322
Score = 88.6 bits (218), Expect = 6e-17
Identities = 175/851 (20%), Positives = 317/851 (37%), Gaps = 93/851 (10%)
Query: 856 NTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLK 915
+T + G L G+ I W +GD I+ R I D + L +K
Sbjct: 23633 DTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESA--RCEIKNTD----FKALLIVK 23686
Query: 916 PADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPE--LEIREVKARSMNLRWTQRF-D 972
A R D + A N G + + V + P PPE +++ V + +L W+ D
Sbjct: 23687 DAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQD 23746
Query: 973 GNSIITGFDIEYKNKSD-SWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRS 1031
G S I+ + +E + S +W S N + L + Y R+ + NK G
Sbjct: 23747 GGSDISHYVVEKRETSRLAWTVVAS----EVVTNSLKVTKLLEGNEYVFRIMAVNKYGVG 23802
Query: 1032 EPSKELTISTEEA-APDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENS 1090
EP + + + GPP + + + S+ V W P + + +I GY + R+ S
Sbjct: 23803 EPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEII-GYIVEKRDRS 23861
Query: 1091 -----PGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINAT 1144
+ + + + ++ TG +E + +Y V A N AG G PS + +
Sbjct: 23862 GIRWIKCNKRRITDLRLRVTGLTEDH---------EYEFRVSAENAAGVGEPSPATVYYK 23912
Query: 1145 TLEDV-PSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQ 1203
+ V PP N + T + ++W +P + +L GY V+ + EW +
Sbjct: 23913 ACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEIL-GY-VVEICKADEEEWQIVT 23970
Query: 1204 NITTTR-ERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPS 1262
T R R E+ + + Y ++V A + G G +SV ED P +
Sbjct: 23971 PQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPE-LDLDSE 24029
Query: 1263 SASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYL 1322
+VV + G R + P G+P P + E F + +G Y
Sbjct: 24030 LRKGIVV------RAGGSARIHI-----PFKGRPTPEITWSREEGEFTDKVQIEKGVNYT 24078
Query: 1323 LWVAAVTSAGRGNSSE---KVTIEPAGKAP---AKIISFGGTVTTPWMKDVRLPCNSVGD 1376
++ + R ++ + K+ K+ K++ G +K+VR +
Sbjct: 24079 Q--LSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVW 24136
Query: 1377 PAPAVKWTKDSEDSAIPVSMDGHRLIHTN--GTLLLRAVKAEDSG-----YYTCTATNTG 1429
P + ++ I + R + N + K E+ Y+ A N
Sbjct: 24137 EPPIIDGGAKVKNYVID-KRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEF 24195
Query: 1430 GF----DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVDN 1484
G +T+ + P ++T++ S +S +L W P +GGS + G+V++
Sbjct: 24196 GVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKG 24255
Query: 1485 SEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKD 1544
+E+W + S + + L G Y+ ++ A N G + + G P +KD
Sbjct: 24256 TEKWS-IVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKS------DPRVLG-VPVIAKD 24307
Query: 1545 QHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREA 1604
+ + ++Q + I ++ RP +W G + V + E +
Sbjct: 24308 LTIQPSLKLPFNTYSIQAGEDLKIEIP-VIGRPRPNISWVKDGEPLKQTTRVNVEETATS 24366
Query: 1605 TWYELR-----------MRACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDV---- 1649
T ++ + A NSAG E L+ G + P++ + D V
Sbjct: 24367 TVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISW 24426
Query: 1650 -KKLFTIGCPV 1659
+T GC +
Sbjct: 24427 EPPAYTGGCQI 24437
Score = 88.2 bits (217), Expect = 8e-17
Identities = 172/744 (23%), Positives = 273/744 (36%), Gaps = 133/744 (17%)
Query: 859 IAIKGHAKELNCTARGERPIIIRWEK-GDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPA 917
I I+G + R + W K G V DR+ D + + L++ +
Sbjct: 14397 IVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTM-------KNDHISAHLEVPKS 14449
Query: 918 DRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDP-PELEIREVKARSMNLRWTQ-RFDGNS 975
R D+ ++ N G I + V P P +++ ++ S L W FDG +
Sbjct: 14450 VRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGT 14509
Query: 976 IITGFDIEYKNKSDSWDFKQSTRNISPTINQAN-----IVDLHPASVYSIRMYSFNKIGR 1030
I + +E + + R P ++ N + DL P Y R+ + NK+G
Sbjct: 14510 PILHYVLERR--------EAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGG 14561
Query: 1031 SE--PSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRE 1088
E K I+ + P PP+DV + T++++ +TWK P L +G
Sbjct: 14562 GEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPP---LYDG----------- 14607
Query: 1089 NSPGSNGQYSIVEMKATGDSE------------VYTLDNLKKFAQYGVVVQAFNRAGTGP 1136
GS I+E A G+ YT L++ +Y V+A N AG
Sbjct: 14608 ---GSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISE 14664
Query: 1137 SSSEINATTLEDVPSQPPENVRALSIT----SDVAV-ISWSEPPRSTLNGVLKGYRVIFW 1191
S T D P P+ + S+ ++A+ S S P T+ + K VI
Sbjct: 14665 PSRATPPTKAVD-PIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWI-KDENVI-- 14720
Query: 1192 SLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDG-----VRSSV----- 1241
V E + R + E++ E F Q L+ + G VR S+
Sbjct: 14721 ---VPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRPDHG 14777
Query: 1242 LYIQTKE---------------DVPGPPAGIKAVPSSASSVVVSWLPPTKPNG-VIRKYT 1285
LY+ E D PGPP +SV+ W PP G I YT
Sbjct: 14778 LYMIKVENDHGIAKAPCTVSVLDTPGPPINFVFEDIRKTSVLCKWEPPLDDGGSEIINYT 14837
Query: 1286 IFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGN---SSEKVTI 1342
+ ++ Y + L G++YL V A G G S V
Sbjct: 14838 LEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAK 14897
Query: 1343 EPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWT--KDSEDSAIPVSMDGHR 1400
+P G A P ++DV NS+ VKW KD+ + ++
Sbjct: 14898 DPFGPPDAP--------DKPIVEDV--TSNSM-----LVKWNEPKDNGSPILGYWLEKRE 14942
Query: 1401 LIHTN----GTLLLRAVKAEDSG-------YYTCTATNTGG-------FDTIIVNLLVQV 1442
+ T+ LL A+KA G + A N G D + +
Sbjct: 14943 VNSTHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPIS- 15001
Query: 1443 PPDQPRLTVSKTSASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSE-RSF 1500
PP P V+ TS+++I L W P NGG I G+ + + + EW + R +
Sbjct: 15002 PPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQY 15061
Query: 1501 KLDSLKCGTWYKVKLAAKNSVGSG 1524
+ ++ G YK++++A N+ G G
Sbjct: 15062 TVKEIREGADYKLRVSAVNAAGEG 15085
Score = 88.2 bits (217), Expect = 8e-17
Identities = 129/557 (23%), Positives = 218/557 (39%), Gaps = 65/557 (11%)
Query: 749 PPRFVVQPNNQDGIYGKAGV---LNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQ 805
PP ++ N + K G L+ + G P PKV WK ++ P RI
Sbjct: 17215 PPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWK--------KEDRDAPTKARID 17266
Query: 806 ILP-NSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGH 864
+ P S L IR+ ED G Y N G S ++VK+ + P + +
Sbjct: 17267 VTPVGSKLEIRNAAHEDGGIYSLTVENPAG-----SKTVSVKVLVLDKPGPPRDLEVSEI 17321
Query: 865 AKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLK----LKPADRG 920
K+ +C + P+ + G +VI V R +A+ ++ K K + G
Sbjct: 17322 RKD-SCYLTWKEPL----DDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEG 17376
Query: 921 DSVFFSCHAINSYGE------DRGLIQLTVQEPPDPP-ELEIREVKARSMNLRWTQ-RFD 972
+ F A N YG + + L PP PP +L +V ++L W + D
Sbjct: 17377 NQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRD 17436
Query: 973 GNSIITGFDIEYKNK-SDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRS 1031
G S ITG+ +EY+ + + W ++ N+ + + L Y R+ + N +G
Sbjct: 17437 GGSPITGYLVEYQEEGTQDWIKFKTVTNL-----ECVVTGLQQGKTYRFRVKAENIVGLG 17491
Query: 1032 EPSKELTISTEE-AAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQI----GY 1086
P + I +E P +DV L T + P +IRG +
Sbjct: 17492 LPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFP------AIIRGVPVPTAKWT 17545
Query: 1087 RENSPGSNGQYSIVEMKATGDSEVYTLDNL--KKFAQYGVVVQAFNRAGTGPSSSEINAT 1144
+ S ++ VE S V T+ N + +Y + V N AG+ + +
Sbjct: 17546 TDGSEIKTDEHYTVE--TDNFSSVLTIKNCLRRDTGEYQITVS--NAAGSKTVAVHL--- 17598
Query: 1145 TLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQN 1204
T+ DVP P + L +T + ISW +PP+ + Y V D WG + +
Sbjct: 17599 TVLDVPGPPTGPINILDVTPEHMTISW-QPPKDDGGSPVINYIVEKQDTRKD-TWGVVSS 17656
Query: 1205 ITTTRERVELRGMEKFTNYSVQVLAYTQAGDG--VRSSVLYIQTKEDVPGPPAGIKAVPS 1262
+++ ++++ ++K Y +V A + G G + S+ + K P PP
Sbjct: 17657 -GSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDI 17715
Query: 1263 SASSVVVSWLPPTKPNG 1279
+ ++ VSW P G
Sbjct: 17716 TENAATVSWTLPKSDGG 17732
Score = 86.7 bits (213), Expect = 2e-16
Identities = 162/733 (22%), Positives = 265/733 (36%), Gaps = 127/733 (17%)
Query: 749 PPRFVVQPNNQDGIY---GKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQ 805
PP + + + GI GK + V G P P +W +G + +
Sbjct: 15101 PPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKDRV---------- 15150
Query: 806 ILPN----SSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAI 861
++ N S L+I+ L +D G Y+ A+N G+ + + +P
Sbjct: 15151 VIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVP------------- 15197
Query: 862 KGHAKELNCTARGERPIIIRWEK----------GDTVIDPDRVM---RYAIATKDNGDEV 908
G +L + ++ W G + D M R I T+ + ++
Sbjct: 15198 -GPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQPIETERSKCDI 15256
Query: 909 VSTLKLKPADRGDSVFFSCHAINSYG-----EDRGLIQLTVQEPPDPPE-LEIREVKARS 962
L+ G F A N +G E ++ + PP PE L E +
Sbjct: 15257 TGLLE------GQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKST 15310
Query: 963 MNLRWTQ-RFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIR 1021
+ L W + R +G S I G+ IE K + D DF++ + + PT + + +L +Y R
Sbjct: 15311 ITLDWKEPRSNGGSPIQGYIIE-KRRHDKPDFERVNKRLCPTTSFL-VENLDEHQMYEFR 15368
Query: 1022 MYSFNKIGRSEPSKEL----------------------TISTEEAAPDGPPMDVTLQPVT 1059
+ + N+IG SEPS L TI + P P DVT P+
Sbjct: 15369 VKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMP 15428
Query: 1060 SQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKF 1119
++ W + ++ QI E S + D YT
Sbjct: 15429 ----KIEWSKNETVIEKPT-DALQITKEEVSRSEAKTELSIPKAVREDKGTYT------- 15476
Query: 1120 AQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTL 1179
V A NR G+ + + + D PS PP N+ I ++ ++W P +
Sbjct: 15477 ------VTASNRLGSVFRNVHVE---VYDRPS-PPRNLAVTDIKAESCYLTWDAPLDNGG 15526
Query: 1180 NGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAG--DGV 1237
+ + + EW E+ N T +R + + Y +V A + G D
Sbjct: 15527 SEITHYVIDKRDASRKKAEWEEVTN-TAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDEC 15585
Query: 1238 RSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPA 1297
+S + IQ +PGPP K + + S++VSW PP NG + G P
Sbjct: 15586 KSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPL-DNGGSPITGYWLEKREEGSPY 15644
Query: 1298 PSEYETSP------EQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAK 1351
S +P + + + + L G +Y A+ +AG G SE E AG
Sbjct: 15645 WSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDP--- 15701
Query: 1352 IISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRL-IHTNGTLLL 1410
I G + P +KD S+G W ++D P+ G+ + + GT
Sbjct: 15702 -IFPPGPPSCPEVKDKTKSSISLG-------WKPPAKDGGSPIK--GYIVEMQEEGTTDW 15751
Query: 1411 RAVKAEDSGYYTC 1423
+ V D TC
Sbjct: 15752 KRVNEPDKLITTC 15764
Score = 85.1 bits (209), Expect = 7e-16
Identities = 149/667 (22%), Positives = 248/667 (37%), Gaps = 90/667 (13%)
Query: 727 YTCIASNAAATVSRERQLIVRVP-------PRFVVQPNNQDGIYGKAGV---LNCSVDGY 776
+ IA NAA +S + + P+ V +D + KAG L V G
Sbjct: 21429 FRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGR 21488
Query: 777 PPPKVMW----KHAKGSGNPQQYHPVPLTGRIQILPNSSLLI-RHVLEEDIGYYLCQASN 831
PPP + W K +G+ + I+I S+ L+ + D G Y A+N
Sbjct: 21489 PPPTMEWSKDGKELEGTAKLE----------IKIADFSTNLVNKDSTRRDSGAYTLTATN 21538
Query: 832 GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP 891
G +K +F VK+ P +A+ E C P+ K D I
Sbjct: 21539 PGG--FAKHIF-NVKVLDR-PGPPEGPLAVTEVTSE-KCVLSWFPPLDDGGAKIDHYIVQ 21593
Query: 892 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYG-----EDRGLIQLTVQE 946
R T + V+ LK+ +G+ F A+N YG E ++ +
Sbjct: 21594 KRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYG 21653
Query: 947 PPDPPE-LEIREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTI 1004
PPDPP+ E+ + SM + W DG S I + +E ++K+ K + + + T
Sbjct: 21654 PPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTL--TD 21711
Query: 1005 NQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTI--STEEAAPDGPPMDVTLQPVTSQS 1062
+ + L Y R+ + N G S PS + + GPP + + + S
Sbjct: 21712 LRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVLDTSRSS 21771
Query: 1063 IQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQY 1122
I + W P + I GY + E + ++ IV A + YT+ L + +Y
Sbjct: 21772 ISIAWNKPIYD-GGSEITGYMV---EIALPEEDEWQIVTPPAGLKATSYTITGLTENQEY 21827
Query: 1123 GVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGV 1182
+ + A N G G + VP P R L PP L+
Sbjct: 21828 KIRIYAMNSEGLGEPAL---------VPGTPKAEDRML-------------PPEIELDAD 21865
Query: 1183 LKGYRVI----FWSLYVDGEWGEMQNITTTR---ERVELRGMEKFTNYSVQVLAYTQAGD 1235
L+ I L+V + + R E ++ +E ++Y++ ++ D
Sbjct: 21866 LRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTLLIVGNVNRFD 21925
Query: 1236 ------------GVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNG-VIR 1282
G +S+ + ++ D PGPP +K + +SV ++W PP G I+
Sbjct: 21926 SGKYILTVENSSGSKSAFVNVRVL-DTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIK 21984
Query: 1283 KYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTI 1342
Y + S + A S T+ + +++ L G Y V A G G +E
Sbjct: 21985 NYIV--EKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAES 22042
Query: 1343 EPAGKAP 1349
A + P
Sbjct: 22043 VKASERP 22049
Score = 85.1 bits (209), Expect = 7e-16
Identities = 205/1008 (20%), Positives = 377/1008 (37%), Gaps = 137/1008 (13%)
Query: 682 GDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNA-----AA 736
G P +TWRKD + + S + +IE+ + S L I V+ G Y N ++
Sbjct: 27297 GRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSS 27356
Query: 737 TVSR---------ERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAK 787
TVS ++ + V V + I G + ++N ++ K W
Sbjct: 27357 TVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVS 27416
Query: 788 GSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI 847
+ + + L+ + + R + E +IG +G
Sbjct: 27417 HKCSSTSFKLIDLSEK------TPFFFRVLAENEIG---------IGEPCE--------- 27452
Query: 848 PAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVM-RYAIATKDNGD 906
T+ P + ++L+ + +I+ W K D D V+ Y + K G+
Sbjct: 27453 ----TTEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPD--FDGGSVITEYVVERKGKGE 27506
Query: 907 EVVS--------TLKLKPADRGDSVFFSCHAINSYG--EDRGLIQLTVQEPPDPPELEIR 956
+ S +++ + F A N G + + +TV+E PE+++
Sbjct: 27507 QTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLS 27566
Query: 957 EVKARSMNLRWTQRFDGNSIITGFDIEYKNK---SDSW-------------DFKQSTRNI 1000
++ + +R G+++ ++ YK K S SW F ++ I
Sbjct: 27567 DIPGAQVTVRI-----GHNV--HLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKI 27619
Query: 1001 SPTINQANIVDLHPASVYSIRMYSFNKIGR-SEPSKELTISTEEAAPDGPPMDVTLQPVT 1059
+ +I A Y++ + N + R + P +T+ + P GP + +
Sbjct: 27620 TLSIKNAK---KEHGGKYTVILD--NAVCRIAVPITVITLGPP-SKPKGP---IRFDEIK 27670
Query: 1060 SQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKF 1119
+ S+ ++W P+ G I Y I RE S +N + + T + + NL K
Sbjct: 27671 ADSVILSWDVPEDN-GGGEITCYSIEKRETSQ-TNWKMVCSSVART----TFKVPNLVKD 27724
Query: 1120 AQYGVVVQAFNRAGTGPS--SSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRS 1177
A+Y V+A NR G SS I A +P P + V ++TSD ++W P
Sbjct: 27725 AEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPV-IYNVTSDGMSLTWDAPVYD 27783
Query: 1178 TLNGVLKGYRVIFWSLYVDGE------WGEMQNITTTRERVELRGMEKFTNYSVQVLAYT 1231
+ V +V+ + W ++ + G+ + +Y +V A
Sbjct: 27784 GGSEVT--------GFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAEN 27835
Query: 1232 QAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IRKYTIFCSS 1290
AG S PP + + ++ + W PP + G I Y+I
Sbjct: 27836 SAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIE-KR 27894
Query: 1291 PGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGN--SSEKVTIEPAGKA 1348
G+ + + T + Y + L+ G +Y + A + G + S I +
Sbjct: 27895 QGNERWVRCNF-TDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDEN 27953
Query: 1349 PAKIISFGGTVTTPWM----KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT 1404
I+ FG + + +R+ G P P V W KD + ++M+ ++ +
Sbjct: 27954 VPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGS 28013
Query: 1405 NGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQ--PRLTVSKTSASSITLT 1462
+L +R + G YT A N G + + VQ P + + + + +TL
Sbjct: 28014 T-SLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLW 28072
Query: 1463 W-IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSV 1521
W P ++G + I ++++ + W + +S+ L G Y+ +++A N
Sbjct: 28073 WDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKF 28132
Query: 1522 GSGR--ISEIIEAK---THGREPSFSKDQHLF-THINSTHARLNLQGWNNGGCPITAIVL 1575
G GR S+ + A+ T P + ++ I T AR ++GG I +L
Sbjct: 28133 GVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPE----SDGGSEIQQYIL 28188
Query: 1576 EYRPKGTWAWQGL---RANSSGEVFLTELREATWYELRMRACNSAGCG 1620
E R K + W + R S +T L E YE + A N+AG G
Sbjct: 28189 ERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVG 28236
Score = 84.0 bits (206), Expect = 1e-15
Identities = 174/825 (21%), Positives = 308/825 (37%), Gaps = 66/825 (8%)
Query: 856 NTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLK 915
+T I G A L G P + W K ++ + IA + + L K
Sbjct: 21469 DTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIA------DFSTNLVNK 21522
Query: 916 PADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPE--LEIREVKARSMNLRWTQRFDG 973
+ R DS ++ A N G + + + V + P PPE L + EV + L W D
Sbjct: 21523 DSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDD 21582
Query: 974 NSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEP 1033
I K ++ + + T + + L + Y R+ + NK G EP
Sbjct: 21583 GGAKIDHYIVQKRETSRLAWTNVASEVQVT--KLKVTKLLKGNEYIFRVMAVNKYGVGEP 21640
Query: 1034 -SKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPG 1092
E ++ P PP + + +T S+ V W P + + +I Y + R+ +
Sbjct: 21641 LESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIIN-YIVERRDKA-- 21697
Query: 1093 SNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG---PSSSEINATTLEDV 1149
GQ I K T Y + L + +Y + A N AG P+S A
Sbjct: 21698 --GQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFK 21755
Query: 1150 PSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTR 1209
P PP N R L + I+W++P + GY V +L + EW I T
Sbjct: 21756 PG-PPGNPRVLDTSRSSISIAWNKPIYDG-GSEITGYMVEI-ALPEEDEW----QIVTPP 21808
Query: 1210 ERVE-----LRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPP-----AGIKA 1259
++ + G+ + Y +++ A G G + V ED PP A ++
Sbjct: 21809 AGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRK 21868
Query: 1260 VPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNR-- 1317
V + + + P K G + G S TS L + ++NR
Sbjct: 21869 VVTIRACCTLRLFVPIK--GRPAPEVKWARDHGESLDKASIESTSSYTLLI-VGNVNRFD 21925
Query: 1318 GQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGT-VTTPWMKDVRLPCNSVGD 1376
+Y+L V + + + +V P K+ T VT W D L
Sbjct: 21926 SGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTW--DPPLLDGGSKI 21983
Query: 1377 PAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF----D 1432
V+ + + + V+ + H+ + + ++ S Y+ A N G +
Sbjct: 21984 KNYIVEKRESTRKAYSTVATNCHKT-----SWKVDQLQEGCSYYFRVLAENEYGIGLPAE 22038
Query: 1433 TIIVNLLVQVPPDQPRLTVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVDNSEEWKD- 1490
T + P ++T+ + +S++L+W P +GGS I G++++ S++W
Sbjct: 22039 TAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATC 22098
Query: 1491 VFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSG---RISEIIEAKTHGREPSFSKDQHL 1547
+ +E + + L G Y +++A+N G ++S + AK P+F +
Sbjct: 22099 ATVKVTEAT--ITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNT 22156
Query: 1548 FTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWY 1607
FT + ++++ G P A+ + A S+ L +++A
Sbjct: 22157 FTVLAGEDLKVDVPFI---GRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACRE 22213
Query: 1608 ELR---MRACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDV 1649
++ ++ NSAG ET LD G P+K + D +
Sbjct: 22214 DVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSI 22258
Score = 83.6 bits (205), Expect = 2e-15
Identities = 147/662 (22%), Positives = 256/662 (38%), Gaps = 112/662 (16%)
Query: 772 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSS---LLIRHVLEEDIGYYLCQ 828
++ G P P+V W+ A+G LT R QI SS L+I +V D G Y
Sbjct: 25130 TIKGRPEPEVKWEKAEGI----------LTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLT 25179
Query: 829 ASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEK-GDT 887
N G SK+ F+ V++ ++ N TI K+ + T E P+I K +
Sbjct: 25180 LENNSG---SKTAFVNVRVLDSPSAPVNLTIR---EVKKDSVTLSWEPPLIDGGAKITNY 25233
Query: 888 VIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYG---EDRGLIQLTV 944
+++ R A AT N + +T +++ G S +F A N YG + V
Sbjct: 25234 IVEKRETTRKAYATITN-NCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKV 25292
Query: 945 QEPPDPP-ELEIREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNK-SDSWDFKQSTRNIS 1001
EPP PP + + +V + ++W + DG S ITG+ +E + K S+ W + +
Sbjct: 25293 SEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLE 25352
Query: 1002 PTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQ 1061
TI+ L Y R+ + N+ GRS+P ++L + PV ++
Sbjct: 25353 ATIS-----GLTAGEEYVFRVAAVNEKGRSDP-RQLGV-----------------PVIAR 25389
Query: 1062 SIQVTWKAPKKELQNGVIRGYQIGYRE----NSPGSNGQYSIVEMKATG----------- 1106
I++ P EL + + RE + P + V + G
Sbjct: 25390 DIEI---KPSVELP---FHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNV 25443
Query: 1107 -DSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSD 1165
S+ T ++K+ ++ V + + S + + D P PP +R ++ D
Sbjct: 25444 SSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPG-PPGPIRIDEVSCD 25502
Query: 1166 VAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSV 1225
ISW+ PP + Y ++ W + + R +++ + + Y
Sbjct: 25503 SITISWN-PPEYDGGCQISNY-IVEKKETTSTTW-HIVSQAVARTSIKIVRLTTGSEYQF 25559
Query: 1226 QVLAYTQAGDG--VRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNG--VI 1281
+V A + G SS + + PGPP K V ++ S+++V+W P G VI
Sbjct: 25560 RVCAENRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVI 25619
Query: 1282 RKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVT 1341
+ + ++ + Q+ +++ L+ G Y V A AG G S+
Sbjct: 25620 GYHLEYKERSSILWSKANKILIADTQM--KVSGLDEGLMYEYRVYAENIAGIGKCSKSCE 25677
Query: 1342 IEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDP--------APAVKWTKDSEDSAIP 1393
PA R PC+ G P + ++KW+K D
Sbjct: 25678 PVPA----------------------RDPCDPPGQPEVTNITRKSVSLKWSKPHYDGGAK 25715
Query: 1394 VS 1395
++
Sbjct: 25716 IT 25717
Score = 83.6 bits (205), Expect = 2e-15
Identities = 263/1281 (20%), Positives = 431/1281 (33%), Gaps = 202/1281 (15%)
Query: 389 GSTVILSCALTGSPEFTIRWYR--------NTELVLPDEAISIRGLSNETLLITSAQKSH 440
G T I+ L + T +WYR NTE +PD + + + +
Sbjct: 29369 GGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEY 29428
Query: 441 SGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVT 500
S + A + + + L D + V+ + G LM + G PPP +T
Sbjct: 29429 S---ESIAEIEPVERIEIPDLELADDLKKTVT------IRAGASLRLMVSVSGRPPPVIT 29479
Query: 501 WALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARI 560
W+ + G ++ + + S + V D G Y A N G +
Sbjct: 29480 WS-------KQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLV 29532
Query: 561 NVRGPPSIRAMRNITAVAGRDTLINCRVI----GYPY--YSIKWYKDALLLPDNHRQVVF 614
V P + V+ I + G P Y ++ + A+ F
Sbjct: 29533 KVYDTPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMR--------AF 29584
Query: 615 ENGTLKLTDVQ---KGMDEGE-YLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIG 670
+ T K + G+ EG Y VL + I + + V L+ PA +
Sbjct: 29585 KTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAV--LVSEVPLVPAKLE 29642
Query: 671 QLLYIPCVVSSGDMPIRITWRK---DGQVIISG---SGVTIESKEFMSSLQISSVSLKHN 724
VV + + W K DG ++G ++ +M + + L+H
Sbjct: 29643 -------VVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHT 29695
Query: 725 GN---------YTCIASNAAATVSRERQLI-------VRVPPRFVVQPNNQDGIYGKAG- 767
+ A N VS R+ + +RV P + Q I+ AG
Sbjct: 29696 VTSLNEGEQYLFRIRAQNEKG-VSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGR 29754
Query: 768 --VLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYY 825
L + G PPP W A + V ++ + L IR D G Y
Sbjct: 29755 PVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKV-----AKLTIRETTIRDTGEY 29809
Query: 826 LCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKG 885
+ N GT T+K+ + P T IK E++ T+ I I WE
Sbjct: 29810 TLELKNVTGTTSE-----TIKVIILDKPGPPTG-PIK--IDEIDATS-----ITISWEPP 29856
Query: 886 DTVIDPDRVMR-YAIATKD---------NGDEVVSTLKLKPADRGDSVFFSCHAINSYGE 935
+ +D + Y + +D + ST K G+ F A N +G
Sbjct: 29857 E--LDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGI 29914
Query: 936 DRGLIQLTVQ-----EPPDPPE-LEIREVKARSMNLRW-TQRFDGNSIITGFDIEYKN-K 987
L ++ P PPE L+I +V M L W DG S +TG+ +E K +
Sbjct: 29915 GSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVR 29974
Query: 988 SDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSK--ELTISTEEAA 1045
+D W + T+ + L Y R+ + N G +PS+ + ++ + A
Sbjct: 29975 ADRW---VRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIA 30031
Query: 1046 PDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKAT 1105
P G P + + T S+ + W P+ E + GY I E +++ T
Sbjct: 30032 PPGKPQNPRVTDTTRTSVSLAWSVPEDE-GGSKVTGYLI---EMQKVDQHEWTKCNTTPT 30087
Query: 1106 GDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSS---SEINATTLEDVPS-QPPENVRALS 1161
E YTL +L + A+Y V A N G G + + T + + P + E +
Sbjct: 30088 KIRE-YTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGI 30146
Query: 1162 ITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFT 1221
VI + P + K + + W+ + + I T+ EL E
Sbjct: 30147 FVRQGGVIRLTIPIKG------KPFPICKWT-KEGQDISKRAMIATSETHTELVIKEADR 30199
Query: 1222 NYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV- 1280
S + G ++ + ++ P ++ SV VSW PP G
Sbjct: 30200 GDSGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGAD 30259
Query: 1281 IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQ-----------QYLLWVAAVT 1329
I Y + E P+ +Y I RG +Y V+A
Sbjct: 30260 ILGYIL-------------ERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAEN 30306
Query: 1330 SAGRG---NSSEKVT-------IEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAP 1379
G S E VT EP P + +V+ W + P + G
Sbjct: 30307 QFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSR----PKDDGGSRVT 30362
Query: 1380 AV----------KWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTG 1429
KW + ++ + I +M + + R + D G + +
Sbjct: 30363 GYYIERKETSTDKWVRHNK-TQITTTMYTVTGLVPDAEYQFRIIAQNDVG----LSETSP 30417
Query: 1430 GFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEW 1488
+ ++ P L + S S+TL W P +GG I G+ ++Y W
Sbjct: 30418 ASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAW 30477
Query: 1489 KDVFISSSER----SFKLDSLKCGTWYKVKLAAKNSVGSGR----ISEIIEAKTHGREPS 1540
K S+ ER F + L T Y+ ++ A+N G R I T G P
Sbjct: 30478 KK---SNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPG 30534
Query: 1541 FSKDQHLFTHINSTHARLNLQ 1561
K+ T A+L+ Q
Sbjct: 30535 IRKEMKDVTTKLGEAAQLSCQ 30555
Score = 83.2 bits (204), Expect = 2e-15
Identities = 222/1067 (20%), Positives = 376/1067 (35%), Gaps = 116/1067 (10%)
Query: 335 RITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPK-----KLKTGI- 388
R+T IS L N G EAT + + P P+ +L+ GI
Sbjct: 23976 RVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIV 24035
Query: 389 ---GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 445
G + + G P I W R E D+ +G++ L I + ++ +G Y
Sbjct: 24036 VRAGGSARIHIPFKGRPTPEITWSRE-EGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYI 24094
Query: 446 CFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDD 505
+ + F + + D TP + + K V F + PP +
Sbjct: 24095 LKLENSSGSKSAFVTVKVLD-TPGPPQNLAVKEVRKDSAFLVW------EPPIIDGGAKV 24147
Query: 506 EPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVY--RCTARNLVG---SAEYQARI 560
+ V D T + + + S + + +G +Y R A N G E +
Sbjct: 24148 KNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAV 24207
Query: 561 NVRGPPSIRAMRNITAVAGRDTLI---------NCRVIGY-----PYYSIKWYKDALLLP 606
PPS +T V+ + RV+GY P + KW A
Sbjct: 24208 KAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKV 24267
Query: 607 DNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPP 666
N +G V+ ++G+ VL P ++ ++ ++K+P F
Sbjct: 24268 CNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLP-----FNTYS 24322
Query: 667 ASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGN 726
G+ L I V P I+W KDG+ + + V +E + L I + G
Sbjct: 24323 IQAGEDLKIEIPVIGRPRP-NISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGK 24381
Query: 727 YTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHA 786
YT A+N+A T + +IV P V P D + V++ Y + +
Sbjct: 24382 YTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYI 24441
Query: 787 --KGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDIS-KSMFL 843
K +H V T + +++ I + + A N G S +
Sbjct: 24442 VEKRDTTTTTWHMVSAT-----VARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAV 24496
Query: 844 TVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEK----GDTVIDPDRVMRYAI 899
V+ P P T T+ + ++++W + G T +++ Y +
Sbjct: 24497 IVQYPFKEPGPPGTPFV----------TSISKDQMLVQWHEPVNDGGT-----KIIGYHL 24541
Query: 900 ATKDNGDEVVSTLKLKPA----------DRGDSVFFSCHAINSYG---EDRGLIQLTVQE 946
K+ + L P D G F A N G + ++
Sbjct: 24542 EQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARD 24601
Query: 947 PPDPP-ELEIREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTI 1004
P DPP E + ++ L+W + +DG S ITG+ +E K+ D K S N+ T
Sbjct: 24602 PCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLET- 24660
Query: 1005 NQANIVDLHPASVYSIRMYSFNKIGR-SEPSKELTISTEEAAPDGPPMDVTLQPVTSQSI 1063
+ + L Y R+ + N G SEPS T D P + +L P I
Sbjct: 24661 -EFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAP--NASLDPKYKDVI 24717
Query: 1064 QVTWKAPKKELQNGVIRGYQIG---YRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFA 1120
V A + + IRG I + ++ + +E+K+T + + +
Sbjct: 24718 VV--HAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTD 24775
Query: 1121 QYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLN 1180
+++ N GT S I L D P P ++ +T++ ++W+ PP
Sbjct: 24776 GGQYILKLSNVGGT--KSIPITVKVL-DRPGPPEGPLKVTGVTAEKCYLAWN-PPLQDGG 24831
Query: 1181 GVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGME-KFT------NYSVQVLAYTQA 1233
+ Y + E E ++ T+ E++ + K T Y +V+A +
Sbjct: 24832 ANISHYII---------EKRETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKY 24882
Query: 1234 GDG--VRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSP 1291
G G + S + PGPP+ + + S+VV+W P G + I
Sbjct: 24883 GIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRD 24942
Query: 1292 GSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE 1338
G + + L R+ L G Y VAA +AG G SE
Sbjct: 24943 KEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSE 24989
Score = 82.8 bits (203), Expect = 3e-15
Identities = 133/636 (20%), Positives = 248/636 (38%), Gaps = 87/636 (13%)
Query: 244 ISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTV 303
IS+ +K D +T +T+ +P S P I+ G V +
Sbjct: 32821 ISETKKSDQKTTESTVTRK-----------TEPKAPEPISSKPVIVTGLQDTTVSSDSVA 32869
Query: 304 ELPCTASGYPIPAIRWLKDGRPLPADSRW----TKRITGLTISDLRTEDSGTYICEVTNT 359
+ A+G P P W KDG+ + ++ K L I T DSG Y C V N+
Sbjct: 32870 KFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNS 32929
Query: 360 FGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPD- 418
GS ++ + I + T +K+ T S + E + + R+ E+ + +
Sbjct: 32930 AGSV-SSSCKLTIKAIKDT-EAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEA 32987
Query: 419 ---EAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFS 475
E ++++ +++ L+ +KS + + + + T A + E T + +FS
Sbjct: 32988 KSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQA--SEEVRTHAEIKAFS 33045
Query: 476 EKV-VNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTG 534
++ +N G++ L GA V W L +G TN G + S +T
Sbjct: 33046 TQMSINEGQRLVLKANIAGA--TDVKWVL-------NGVELTNSEEYRYGVSGSDQTLTI 33096
Query: 535 PQI--RDGGVYRCTARNLVGSAEYQARINVR-----GPPSIRAMRNITAVAGRDTLINCR 587
Q RD G+ C ++ G + Q + + P I R+ G++ L C
Sbjct: 33097 KQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCE 33156
Query: 588 VIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKG--MDEGEYLCSVL-IQPQLS 644
+ G P I+W+K+ L + + + + + +++ D G+Y + Q S
Sbjct: 33157 ISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCS 33216
Query: 645 ISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVI------I 698
+ S+ V PL+ E P + + +SGD ++ ++ +
Sbjct: 33217 ATASLMVL----PLV---EEPSREV-------VLRTSGDTSLQGSFSSQSVQMSASKQEA 33262
Query: 699 SGSGVTIESKEFMSSLQISSVSLKH----NGNYTCIASNAAATVSRERQL---------- 744
S S + S M+ ++ +S+S + ++ ++S++ +S QL
Sbjct: 33263 SFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKA 33322
Query: 745 -IVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGR 803
I +PP+ P++ GK + C+ G P P+V W + Q+ GR
Sbjct: 33323 GIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQE------QGR 33376
Query: 804 IQILPN---SSLLIRHVLEEDIGYYLCQASNGVGTD 836
I ++L+I V ++D G Y N G+D
Sbjct: 33377 FHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSD 33412
Score = 82.4 bits (202), Expect = 4e-15
Identities = 147/658 (22%), Positives = 255/658 (38%), Gaps = 90/658 (13%)
Query: 746 VRVPPRFVVQPNNQDGIYGKAGV---LNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
+ +PP + + + + +AGV L V G PPPK+ W V L
Sbjct: 19687 ILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPN----------VNLRD 19736
Query: 803 RIQILPNSS-----LLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNT 857
RI + S+ L +V + D G Y+ N G K + VK+ + T P
Sbjct: 19737 RIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCG---KKEYTIVVKV--LDTPGPPV 19791
Query: 858 TIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTL----- 912
+ +K +K+ + E PII + G +I+ Y + +D + ST+
Sbjct: 19792 NVTVKEISKD-SAYVTWEPPII---DGGSPIIN------YVVQKRDAERKSWSTVTTECS 19841
Query: 913 ----KLKPADRGDSVFFSCHAINSY-----GEDRGLIQLTVQEPPDPPELEIREVKARSM 963
++ + G S FF A N Y GE R ++ + Q P +L++R V S
Sbjct: 19842 KTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKAS-QTPGPVVDLKVRSVSKSSC 19900
Query: 964 NLRWTQ-RFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRM 1022
++ W + DG S I G+ +++ + + W + ++ Q + DL Y+ R+
Sbjct: 19901 SIGWKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSL-----QYSAKDLTEGKEYTFRV 19955
Query: 1023 YSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQP----VTSQSIQVTWKAPKKELQNGV 1078
+ N+ G PS+ ++ ++ P +D+ P + ++ K P K G
Sbjct: 19956 SAENENGEGTPSEITVVARDDVV--APDLDLKGLPDLCYLAKENSNFRLKIPIK----GK 20009
Query: 1079 IRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSS 1138
+ P + VE A + + +Y + ++ N AGT +
Sbjct: 20010 PAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLK--NVAGTKEGT 20067
Query: 1139 SEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGE 1198
I +P+ P ++ +T++ + W+ PP+ + Y ++ V+ +
Sbjct: 20068 ISIKVVGKPGIPTGP---IKFDEVTAEAMTLKWA-PPKDDGGSEITNY-ILEKRDSVNNK 20122
Query: 1199 W---GEMQNITTTRERVELRGMEKFTNYSVQVLAYTQ--AGDGVRSSVLYIQTKEDVPGP 1253
W TT R GME Y+ +V A + G+G++S + + DVP
Sbjct: 20123 WVTCASAVQKTTFRVTRLHEGME----YTFRVSAENKYGVGEGLKSEPIVARHPFDVPDA 20178
Query: 1254 PAGIKAVPSSASSVVVSWLPPTKPNG-VIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRI 1312
P V SV ++W P K G I Y + S + +T +++
Sbjct: 20179 PPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRAN-KTPIRMRDFKV 20237
Query: 1313 AHLNRGQQYLLWVAAVTSAGRGN---SSEKVT----IEPAGKAPAKIISFGGTVTTPW 1363
L G +Y V A+ AG G SE V I+P GK P I +VT W
Sbjct: 20238 TGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGK-PEVINITRNSVTLIW 20294
Score = 80.9 bits (198), Expect = 1e-14
Identities = 139/581 (23%), Positives = 226/581 (38%), Gaps = 62/581 (10%)
Query: 748 VPPRFVVQPNNQ-DGIYGKAGV---LNCSVDGYPPPKVMW-KHAKGSGNPQQYHPVPLTG 802
VPP ++ + + D I KAG + V G P PK+ W K+ P +
Sbjct: 15393 VPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEE 15452
Query: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIK 862
+ + L I + ED G Y ASN +G S+F V + P +A+
Sbjct: 15453 VSRSEAKTELSIPKAVREDKGTYTVTASNRLG-----SVFRNVHVEVYDRPSPPRNLAVT 15507
Query: 863 GHAKELNCTARGERPIIIRWEKGDTVIDPDRV-MRYAIATKDNGDEVVSTL--------K 913
E +C + P+ + G + I + R A K +EV +T K
Sbjct: 15508 DIKAE-SCYLTWDAPL----DNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWK 15562
Query: 914 LKPADRGDSVFFSCHAINSYG------EDRGLIQLTVQEPPDPPELEIREVKARSMNLRW 967
L P + + F A+N YG D+ +IQ + P P + ++ SM + W
Sbjct: 15563 LIPNGQYE---FRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSW 15619
Query: 968 TQRFD-GNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQA---NIVDLHPASVYSIRMY 1023
T D G S ITG+ +E + + + + S I+ + N+ L Y R
Sbjct: 15620 TPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAM 15679
Query: 1024 SFNKIGRSEPSK--ELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRG 1081
+ N G PS+ + ++ + P GPP ++ T SI + WK P K+ I+G
Sbjct: 15680 AINAAGIGPPSEPSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAKD-GGSPIKG 15738
Query: 1082 YQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSS--- 1138
Y + +E G+ + E + + NLK+ +Y V+A N AG S
Sbjct: 15739 YIVEMQEE--GTTDWKRVNEPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESEPSDTT 15796
Query: 1139 SEINATTLE-------DVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFW 1191
EI AT ++ D+ +Q +A S AVI P+S+ K + +
Sbjct: 15797 GEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKD 15856
Query: 1192 SLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP 1251
++ E +++ + + T + A +AG + + + DVP
Sbjct: 15857 GVHDIPEDAQLETAENSSVIIIPECKRSHTG-KYSITAKNKAGQKTANCRVKVM---DVP 15912
Query: 1252 GPPAGIKAVPSSASSVVVSWLPPTKPNG------VIRKYTI 1286
GPP +K + S +SW P G VI K TI
Sbjct: 15913 GPPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTI 15953
Score = 79.7 bits (195), Expect = 3e-14
Identities = 184/878 (20%), Positives = 321/878 (36%), Gaps = 107/878 (12%)
Query: 817 VLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGER 876
VL ++ + + S G + + K H + G L+ G+
Sbjct: 29016 VLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKP 29075
Query: 877 PIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGED 936
I W KGD +D + ++ + G + +K DR DS ++ N+ G
Sbjct: 29076 EPKIIWTKGDKELD----LCEKVSLQYTGKRATAVIKF--CDRSDSGKYTLTVKNASGTK 29129
Query: 937 RGLIQLTVQEPPDP-PELEIREVKARSMNLRWT-QRFDGNSIITGFDIEYKNKSD-SWDF 993
+ + V + P P +L + V L W+ + DG + IT + +E + S +W
Sbjct: 29130 AVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVI 29189
Query: 994 KQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEA----APDGP 1049
+ PT++ + L + Y R+ + NK G P + I + +P G
Sbjct: 29190 VEGE---CPTLSYV-VTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGI 29245
Query: 1050 PMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSE 1109
P +V + I + W P+ + N I Y + RE S+ + D
Sbjct: 29246 PEEV---GTGKEHIIIQWTKPESDGGN-EISNYLVDKREKK-------SLRWTRVNKDYV 29294
Query: 1110 VY----TLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQ---PPENVRALSI 1162
VY + +L + Y V A N AG S N + + PS PP R +
Sbjct: 29295 VYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCRE-PSYTPGPPSAPRVVDT 29353
Query: 1163 TSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTN 1222
T ++W++P ++ GY + D + N T + ++
Sbjct: 29354 TKHSISLAWTKPMYDGGTDIV-GYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQK 29412
Query: 1223 YSVQVLAYTQAGDGVRS-SVLYIQTKEDVPGP----------PAGIKAVPSSASSVVVSW 1271
YS +V A G S S+ I+ E + P I+A S V VS
Sbjct: 29413 YSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSG 29472
Query: 1272 LPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSA 1331
PP I S G + + +T+ + +NR + A +
Sbjct: 29473 RPPP---------VITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQS 29523
Query: 1332 GRGNSSEKVTI-EPAGKAPAKIIS--FGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE 1388
G+ +++ V + + G P+ + +VT W +P ++ AP + +
Sbjct: 29524 GKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITW----EIP--TIDGGAPVNNYIVEKR 29577
Query: 1389 DSAIPVSMDGHRLIHTNGTLLLRAVKAEDSG---YYTCTATNTGGF----DTIIVNLLVQ 1441
++A M + + T + L + G Y+ N G +T L+ +
Sbjct: 29578 EAA----MRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSE 29633
Query: 1442 VPPDQPRLTVSKTSASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEW-KDVFISSSERS 1499
VP +L V + S++TL W P +GGS + G+VL+ +E W K V + +
Sbjct: 29634 VPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLE 29693
Query: 1500 FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHIN-STHARL 1558
+ SL G Y ++ A+N G E + A T +D + I+ ST +
Sbjct: 29694 HTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVT-------VQDLRVLPTIDLSTMPQK 29746
Query: 1559 NLQGWNNGGCPITAIVL---EYRPKGTWAWQGLRANSSGEVFL-------------TELR 1602
+ G P+ ++ P +W + G + S V + T +R
Sbjct: 29747 TIH--VPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIR 29804
Query: 1603 EATWYELRMRACNSAGCGNETAQFATLDYDGSTIPPIK 1640
+ Y L ++ N G +ET + LD G PIK
Sbjct: 29805 DTGEYTLELK--NVTGTTSETIKVIILDKPGPPTGPIK 29840
Score = 79.0 bits (193), Expect = 5e-14
Identities = 167/741 (22%), Positives = 288/741 (38%), Gaps = 94/741 (12%)
Query: 829 ASNGVGTDISKSMFLTVKIPAMITS--------HPNTTIAIKGHAKELNCTARGERPIII 880
A NG G S + T+K +T+ T + G + L +G
Sbjct: 28330 AINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTA 28389
Query: 881 RWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLI 940
W K D+ + +R I T D+ STL ++ +R D+ ++ N+ G
Sbjct: 28390 VWSKPDSNLS----LRADIHTTDS----FSTLTVENCNRNDAGKYTLTVENNSGSKSITF 28441
Query: 941 QLTVQEPPDPP-ELEIREVKARSMNLRW-TQRFDGNSIITGFDIEYKNKS-DSWDF--KQ 995
+ V + P PP + ++V S L W DG + I + +E + S SW ++
Sbjct: 28442 TVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKREASRRSWQVISEK 28501
Query: 996 STRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSK--ELTISTEEAAPDGPPMDV 1053
TR I + DL Y R+ + N+ G EP + E ++TE+ A PP +
Sbjct: 28502 CTRQI------FKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPA---PPRRL 28552
Query: 1054 TLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTL 1113
+ + S + W P + I GY + R+ G VE T +T+
Sbjct: 28553 DVVDTSKSSAVLAWLKPDHD-GGSRITGYLLEMRQ-----KGSDFWVEAGHT-KQLTFTV 28605
Query: 1114 DNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSE 1173
+ L + +Y V+A N AG ++ +++ +P ++ IT+ +
Sbjct: 28606 ERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADL--TGITNQLITCKAGS 28663
Query: 1174 PPRSTLNGVLKGYRV--IFWSL-YVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAY 1230
P T++ + G + W L + + + +ITTT++R L + S +
Sbjct: 28664 P--FTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLT 28721
Query: 1231 TQAGDGVRS-SVLYIQTKEDVPGPPAG-IKAVPSSASSVVVSWLPPTKPNGV-IRKYTIF 1287
+ GV++ SV + PGP G I+ SA S V+SW P G I Y +
Sbjct: 28722 LENTAGVKTFSVTVVVIGR--PGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIV- 28778
Query: 1288 CSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGK 1347
SG A +S ++ ++ HL + +Y V++ G +P
Sbjct: 28779 -EKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFG--------VSKPLES 28829
Query: 1348 APAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGT 1407
AP II+ V P R V A +++W + D + G+ +
Sbjct: 28830 AP--IIAEHPFV--PPSAPTRPEVYHVSANAMSIRWEEPYHDGGSKII--GYWVEKKERN 28883
Query: 1408 LLLRAVKAEDSGYYTCTATNTG-------GFDTIIVN-------------LLVQVPPDQP 1447
+L VK C TG F T +N ++ Q P D P
Sbjct: 28884 TIL-WVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAP 28942
Query: 1448 -RLTVSKTSASSITLTW-IPGDNGGSSIRGFVLQ----YSVDNSEEWKDVFISSSERSFK 1501
R V+ + S+++L W P +GGS + G++++ V + K + S+ F
Sbjct: 28943 GRPEVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFT 29002
Query: 1502 LDSLKCGTWYKVKLAAKNSVG 1522
+ +L G Y+ ++ AKN+ G
Sbjct: 29003 VTALSEGDTYEFRVLAKNAAG 29023
Score = 77.8 bits (190), Expect = 1e-13
Identities = 141/691 (20%), Positives = 251/691 (36%), Gaps = 91/691 (13%)
Query: 871 TARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPAD---RGDSVFFSC 927
T +G ++WEK + ++ DR EV S+ + D R DS ++
Sbjct: 25130 TIKGRPEPEVKWEKAEGILT-DRAQI----------EVTSSFTMLVIDNVTRFDSGRYNL 25178
Query: 928 HAINSYGEDRGLIQLTVQEPPDPP-ELEIREVKARSMNLRW-TQRFDGNSIITGFDIEYK 985
N+ G + + V + P P L IREVK S+ L W DG + IT + +E K
Sbjct: 25179 TLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVE-K 25237
Query: 986 NKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAA 1045
++ + T N + T I +L Y R+ + N+ G P+ E T + +
Sbjct: 25238 RETTRKAYATITNNCTKT--TFRIENLQEGCSYYFRVLASNEYGIGLPA-ETTEPVKVSE 25294
Query: 1046 PDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKAT 1105
P PP VTL VT + + W+ P E+ GS +VEM+
Sbjct: 25295 PPLPPGRVTLVDVTRNTATIKWEKP-----------------ESDGGSKITGYVVEMQTK 25337
Query: 1106 GDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSD 1165
G + T +K ++A T + + P + I D
Sbjct: 25338 GSEKWSTCTQVK-------TLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARD 25390
Query: 1166 VAVISWSEPPRSTLNGVLKGYRVIFWSLYVDG------EWGEMQNITTTRERVELRGMEK 1219
+ + E P T N +K + + G W + RV + +
Sbjct: 25391 IEIKPSVELPFHTFN--VKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKT 25448
Query: 1220 FTNYSVQ----------VLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVV 1269
T+ S++ L + + + + I D PGPP I+ S S+ +
Sbjct: 25449 VTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVL--DRPGPPGPIRIDEVSCDSITI 25506
Query: 1270 SWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAV 1328
SW PP G I Y + + + + +I L G +Y V A
Sbjct: 25507 SWNPPEYDGGCQISNYIV--EKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAE 25564
Query: 1329 TSAGRGNSSEKVTI------EPAGK--APAKIISFGGTVTTPWMKDVRLPCNSVGDPAPA 1380
G+ + SE + P G P + + T+ W ++P N G +
Sbjct: 25565 NRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTW----QVPVNDGG--SRV 25618
Query: 1381 VKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV 1440
+ + + ++ + + ++++ + + + + Y A N G +
Sbjct: 25619 IGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEP 25678
Query: 1441 QV------PPDQPRLTVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVDNSEEW-KDVF 1492
PP QP +T + S++L W P +GG+ I G++++ W K +
Sbjct: 25679 VPARDPCDPPGQPEVT--NITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNY 25736
Query: 1493 ISSSERSFKLDSLKCGTWYKVKLAAKNSVGS 1523
+ E F++ L Y+ ++ A+N+ S
Sbjct: 25737 TNIQETYFEVTELTEDQRYEFRVFARNAADS 25767
Score = 77.4 bits (189), Expect = 1e-13
Identities = 120/536 (22%), Positives = 203/536 (37%), Gaps = 41/536 (7%)
Query: 764 GKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIG 823
G+A L+C + G P P + W + + + GR +L + +ED G
Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTH-----TLTVMTEEQEDEG 30601
Query: 824 YYLCQASNGVGTDISKSMFLTVKIPAMITSHP--NTTIAIKGHAKELNCTARGERPIIIR 881
Y C A+N VG + S L P +P G L+ G +
Sbjct: 30602 VYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMT 30661
Query: 882 WEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQ 941
W G ++ + T +N + + + + + N +G ++
Sbjct: 30662 WFHGQKLLQNSENI-----TIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILD 30716
Query: 942 LTVQEPPDPP--ELEIREVKARSMNLRW-TQRFDGNSIITGFDIEYKNKSDSWDFKQSTR 998
+ +Q+ PD P + I + S + W DG S IT + +E + +++ +
Sbjct: 30717 VEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSS 30776
Query: 999 NISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSK--ELTISTEEAAPDGPPMDVTLQ 1056
IS + IV+L + Y R+ + N G S+P + + I G P T+
Sbjct: 30777 AIS--VTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTIT 30834
Query: 1057 PVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNL 1116
VT S V WK P + IR Y + RE + E++ T V+++ NL
Sbjct: 30835 AVTKDSCVVAWKPPASD-GGAKIRNYYLEKREKKQNKWISVTTEEIRET----VFSVKNL 30889
Query: 1117 KKFAQYGVVVQAFNRAGTGPSSSEIN--ATTLEDVPSQPP---ENVRALSI---TSDVAV 1168
+ +Y V+ N G SEI+ T DVP Q P E +R L++ ++ V
Sbjct: 30890 IEGLEYEFRVKCENLGGES-EWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLV 30948
Query: 1169 ISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVL 1228
+ P+ + +G +I DG +Q ++ + + QV
Sbjct: 30949 CKVTGHPKPIVKWYRQGKEII-----ADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVR 31003
Query: 1229 AYTQAG--DGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLP-PTKPNGVI 1281
A Q G G S + + K +P G+ AV + VV +P KP+ VI
Sbjct: 31004 ATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVI 31059
Score = 76.6 bits (187), Expect = 2e-13
Identities = 142/675 (21%), Positives = 250/675 (37%), Gaps = 98/675 (14%)
Query: 220 SWEKDTVSIIPEHRFFITYHGGLYISD-------VQKEDALSTYRCITKHKYSGETRQSN 272
+W+K I + +F I GGL + + E LS R + S +T+ ++
Sbjct: 30476 AWKKSNKERIKDKQFTI---GGLLEATEYEFRVFAENETGLSRPR---RTAMSIKTKLTS 30529
Query: 273 GARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRW 332
G + + + T L G +L C G P+P I+W + G+ L ++
Sbjct: 30530 GEAPGIRKEMKDVTTKL----------GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKY 30579
Query: 333 TKRITG----LTISDLRTEDSGTYICEVTNTFGSAEATG-ILMVIDPLHVTLTPKKLK-- 385
G LT+ ED G Y C TN G E + +L+ P P K K
Sbjct: 30580 KMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYY 30639
Query: 386 TGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITS--AQKSHSGA 443
+GST+ L G P + W+ +L+ E I+I + T L+ +K+H+G
Sbjct: 30640 GAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGK 30699
Query: 444 YQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWAL 503
Y+ + T + ++D + V+ + S + + K +W
Sbjct: 30700 YKVQLSNVFGTVDAILDVEIQDKPDKPTGPI---VIEALLKNSAVISWKPPADDGGSWIT 30756
Query: 504 DDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSA---EYQARI 560
+ + +S +++ + G +R +A+N G + E + +
Sbjct: 30757 NYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVV 30816
Query: 561 NVRGP---PSIRAMRNITAVAGRDTLINCRVIGYP-----------YY----SIKWYKDA 602
++ P P ITAV T +C V P YY K K
Sbjct: 30817 IIKSPFEKPGAPGKPTITAV----TKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWI 30872
Query: 603 LLLPDNHRQVVFENGTLKLTDVQKGMD----------EGEYLCSVLIQPQLSISQSVHVA 652
+ + R+ VF + ++ +G++ GE S + +P I+ V
Sbjct: 30873 SVTTEEIRETVF-----SVKNLIEGLEYEFRVKCENLGGESEWSEISEP---ITPKSDVP 30924
Query: 653 VKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMS 712
++ P + + C V+ PI + W + G+ II+ G+ +EF
Sbjct: 30925 IQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPI-VKWYRQGKEIIA-DGLKYRIQEFKG 30982
Query: 713 ---SLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDG------IY 763
L I+SV+ Y A+N +VS L V VP + + P +G +
Sbjct: 30983 GYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAK-IHLPKTLEGMGAVHALR 31041
Query: 764 GKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQ--ILPNSSLLIRHVLEED 821
G+ + G P P + W+ + + ++ V +T + PN V +D
Sbjct: 31042 GEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNG------VERKD 31095
Query: 822 IGYYLCQASNGVGTD 836
G+Y+ A N G D
Sbjct: 31096 AGFYVVCAKNRFGID 31110
Score = 74.7 bits (182), Expect = 9e-13
Identities = 147/687 (21%), Positives = 237/687 (34%), Gaps = 104/687 (15%)
Query: 744 LIVRVPPRFVVQPNNQDGIYGKAGV---LNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPL 800
L VPPR + + + KAG L+ +V G P P V WK P + + +
Sbjct: 19287 LAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAM 19346
Query: 801 TGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIA 860
+ +L + V +D G Y A N G SKS T+K+ + P ++
Sbjct: 19347 QRNL-----CTLELFSVNRKDSGDYTITAENSSG---SKS--ATIKLKVLDKPGPPASVK 19396
Query: 861 IKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPAD-- 918
I + E P+ E G + I + ++ ++ N +V +T+ +
Sbjct: 19397 INKMYSD-RAMLSWEPPL----EDGGSEI-TNYIVDKRETSRPNWAQVSATVPITSCSVE 19450
Query: 919 ---RGDSVFFSCHAINSYGE-----DRGLIQLTVQEPP---DPPELEIREVKARSMNLRW 967
G F A N YG I +PP DPP I + M + W
Sbjct: 19451 KLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPP--VISNITKDHMTVSW 19508
Query: 968 -TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQA-NIVDLHPASVYSIRMYSF 1025
DG S ITG+ +E K ++ + N P I + L + Y R+ +
Sbjct: 19509 KPPADDGGSPITGYLLE---KRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAI 19565
Query: 1026 NKIGRSEPS--KELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQ 1083
NK G +PS + + + P GPP + T S+ ++W P + + +I GY
Sbjct: 19566 NKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPII-GYL 19624
Query: 1084 IGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINA 1143
+ E + + + + + L + QY V A N+ G S
Sbjct: 19625 V---EVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPS----- 19676
Query: 1144 TTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRV----IFWSLYVDGEW 1199
DVP + D+ + PP L+ L+ + + LYV +
Sbjct: 19677 ----DVPDK--------HYPKDILI-----PPEGELDADLRKTLILRAGVTMRLYVPVKG 19719
Query: 1200 GEMQNITTTRERVELRG----------------MEKFTNYSVQVLAYTQAGDGVRSSVLY 1243
IT ++ V LR E Y T +
Sbjct: 19720 RPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTI 19779
Query: 1244 IQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNG-VIRKYTIFCSSPGSGQPAPSEYE 1302
+ D PGPP + S S V+W PP G I Y + + + + S
Sbjct: 19780 VVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVV--QKRDAERKSWSTVT 19837
Query: 1303 TSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTP 1362
T + +R+A+L G+ Y V A G G+ E A + P ++
Sbjct: 19838 TECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVD-------- 19889
Query: 1363 WMKDVRLPCNSVGDPAPAVKWTKDSED 1389
L SV + ++ W K D
Sbjct: 19890 ------LKVRSVSKSSCSIGWKKPHSD 19910
Score = 73.6 bits (179), Expect = 2e-12
Identities = 134/636 (21%), Positives = 241/636 (37%), Gaps = 94/636 (14%)
Query: 688 ITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVR 747
+ WRKDGQ + + V + S + ++SL I S + G Y SN+A +++ +IV
Sbjct: 25426 VNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVL 25485
Query: 748 VPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQ-------QYHPVPL 800
P G G + + W + G Q +
Sbjct: 25486 DRP-------------GPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTST 25532
Query: 801 TGRI--QILPNSSL-LIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNT 857
T I Q + +S+ ++R + + +C + + S+S + + P P T
Sbjct: 25533 TWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPGT 25592
Query: 858 TIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVS------- 910
+ HA + + P+ G + RV+ Y + K+ + S
Sbjct: 25593 PKVV--HATKSTMLVTWQVPV----NDGGS-----RVIGYHLEYKERSSILWSKANKILI 25641
Query: 911 ---TLKLKPADRGDSVFFSCHAINSYGE---DRGLIQLTVQEPPDPP-ELEIREVKARSM 963
+K+ D G + +A N G + + ++P DPP + E+ + +S+
Sbjct: 25642 ADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPCDPPGQPEVTNITRKSV 25701
Query: 964 NLRWTQ-RFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRM 1022
+L+W++ +DG + ITG+ +E + D K + NI T + + +L Y R+
Sbjct: 25702 SLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFE--VTELTEDQRYEFRV 25759
Query: 1023 YSFNKIGR-SEPSKEL--TISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVI 1079
++ N SEPS+ I ++ P MDV + V + KA + N I
Sbjct: 25760 FARNAADSVSEPSESTGPIIVKDDVEPPRVMMDVKFRDV------IVVKAGEVLKINADI 25813
Query: 1080 RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDN----------LKKFAQYGVVVQAF 1129
G + P + +E++ +E+ + DN + QY V+
Sbjct: 25814 AGRPL------PVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQY--VLTLK 25865
Query: 1130 NRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVI 1189
N AGT S +N L D P P + +T++ +SW P G Y ++
Sbjct: 25866 NVAGT--RSVAVNCKVL-DKPGPPAGPLEINGLTAEKCSLSWGRPQED--GGADIDYYIV 25920
Query: 1190 FWSLYVDGEW----GEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQ 1245
W GE+Q +T+ + L+G E Y +V + G G + I+
Sbjct: 25921 EKRETSHLAWTICEGELQ-MTSCKVTKLLKGNE----YIFRVTGVNKYGVGEPLESVAIK 25975
Query: 1246 TKE--DVPGPPAGIKAVPSSASSVVVSWLPPTKPNG 1279
+ VP PP ++ + S+ + W P G
Sbjct: 25976 ALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGG 26011
Score = 73.6 bits (179), Expect = 2e-12
Identities = 72/305 (23%), Positives = 117/305 (38%), Gaps = 24/305 (7%)
Query: 276 LSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWT-- 333
L+++ P + SQ + G V C SG P P I W K+ P+ S +
Sbjct: 33124 LTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSIS 33183
Query: 334 --KRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGST 391
+ + L I + DSG Y + N G AT LMV+ + L+T G T
Sbjct: 33184 RSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTS-GDT 33242
Query: 392 VILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRK 451
+ + S + + E + S E + + +S S + F
Sbjct: 33243 SLQGSFSSQSVQMSAS---KQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMS 33299
Query: 452 AQTAQDFA-IIALEDGT------------PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPT 498
+ + + + LE T P+I + S+ ++ G+ ++ CA G P P
Sbjct: 33300 SSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPE 33359
Query: 499 VTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQA 558
VTW+ I R + D TT+ M+V Q +DGG+Y + N GS
Sbjct: 33360 VTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDV---QKQDGGLYTLSLGNEFGSDSATV 33416
Query: 559 RINVR 563
I++R
Sbjct: 33417 NIHIR 33421
Score = 71.6 bits (174), Expect = 8e-12
Identities = 179/836 (21%), Positives = 292/836 (34%), Gaps = 137/836 (16%)
Query: 875 ERPIIIRWEKGDTVIDPDR-VMRYAIATKDN-GDEVVSTLKLKPAD---------RGDSV 923
+R + ++WE D R + RY I K+ G V K D G V
Sbjct: 14197 KRHVDLKWEPPKN--DGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEV 14254
Query: 924 FFSCHAINSYG---EDRGLIQLTVQEPPDPP----ELEIREVKARSMNLRWTQ-RFDGNS 975
F A N G L++++P PP +L + + + + + W +G S
Sbjct: 14255 QFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGS 14314
Query: 976 IITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSK 1035
I G+ +E + ++R I + + P Y +R+ + N IG SEPS
Sbjct: 14315 PIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVE-EGVVPDKEYVLRVRAVNAIGVSEPS- 14372
Query: 1036 ELTISTEEAAPDGPPM------DVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYREN 1089
E++ + PD P D+ + SI V ++A + G ++ +
Sbjct: 14373 EISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDR 14432
Query: 1090 SPGSNGQYSI---VEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTL 1146
N S V D+ +YT + N+ G+ +S + L
Sbjct: 14433 LTMKNDHISAHLEVPKSVRADAGIYT-------------ITLENKLGSATASINVKVIGL 14479
Query: 1147 EDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGY----RVIFWSLYVDGEWGEM 1202
P ++++A IT ++W EPP + Y R Y+ GE
Sbjct: 14480 PG----PCKDIKASDITKSSCKLTW-EPPEFDGGTPILHYVLERREAGRRTYIPVMSGEN 14534
Query: 1203 QNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDV--------PGPP 1254
+ T ++ + Y +V A + G G YI+ K V P PP
Sbjct: 14535 KLSWTVKDLIPNG------EYFFRVKAVNKVGGGE-----YIELKNPVIAQDPKQPPDPP 14583
Query: 1255 AGIKAVPSSASSVVVSWLPPTKPNG-VIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIA 1313
++ +A ++ ++W PP G I Y I + G + P L Y
Sbjct: 14584 VDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVP-ILTYTAK 14642
Query: 1314 HLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKA----PAKIISFGGTVTTPWMKDVRL 1369
L G++Y V A +AG SE P KA A + ++ ++ L
Sbjct: 14643 GLEEGKEYQFRVRAENAAG---ISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGDEIAL 14699
Query: 1370 PCNSVGDPAPAVKWTKDSEDSAIP-------------------------------VSMDG 1398
+ G P P + W KD E+ +P +S+D
Sbjct: 14700 DASISGSPYPTITWIKD-ENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDN 14758
Query: 1399 HRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQP-RLTVSKTSAS 1457
+ L +R D G Y N G + V P P +
Sbjct: 14759 SK--KGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPINFVFEDIRKT 14816
Query: 1458 SITLTWIPG-DNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKC--GTWYKVK 1514
S+ W P D+GGS I + L+ + + + ++S+ R K K G Y +
Sbjct: 14817 SVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFR 14876
Query: 1515 LAAKNSVGSGR--ISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITA 1572
+ A+N G G +S+ + AK P + D+ + + S + + G PI
Sbjct: 14877 VRAENRFGPGPPCVSKPLVAKDPFGPPD-APDKPIVEDVTSNSMLVKWNEPKDNGSPILG 14935
Query: 1573 IVLEYRPKGTWAW--------QGLRANSSGEVFLTELREATWYELRMRACNSAGCG 1620
LE R + W L+AN G L E Y R+ A N+AG G
Sbjct: 14936 YWLEKREVNSTHWSRVNKSLLNALKANVDG------LLEGLTYVFRVCAENAAGPG 14985
Score = 70.5 bits (171), Expect = 2e-11
Identities = 144/703 (20%), Positives = 244/703 (34%), Gaps = 91/703 (12%)
Query: 296 EVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG----LTISDLRTEDSGT 351
EV T C S + +P++ WLK+G + ++ + G L I + TEDS
Sbjct: 2892 EVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAE 2950
Query: 352 YICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN 411
Y N SA T + P+ +T K + T+ + + +W +N
Sbjct: 2951 YTFVCGNDQVSATLT-----VTPIMITSMLKDINAEEKDTITFEVTVNYEG-ISYKWLKN 3004
Query: 412 -TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRI 470
E+ D+ +L I + + Y A + TA + +E
Sbjct: 3005 GVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTAT----LYVEARHIEF 3060
Query: 471 VSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHM 530
+ V ++ C P TV W DD+ + T++ + + +
Sbjct: 3061 RKHIKDIKVLEKKRAMFECEVS-EPDITVQWMKDDQEL-----QITDRIKIQKEKYVHRL 3114
Query: 531 NVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPP-SIRAMRNITAVAGRDTLINCRVI 589
+ ++ D G Y A V +A ++ V G IR+++ V + + +
Sbjct: 3115 LIPSTRMSDAGKYTVVAGGNVSTA----KLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEV 3170
Query: 590 GYPYYSIKWYKDALLL----PDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSI 645
WYKD + + + H+ VV + D GEY + +
Sbjct: 3171 NEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEY---TFVAGRNRS 3227
Query: 646 SQSVHVAVKVPPLIQPFEFPPASI--GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGV 703
S +++V PP + E P ++ G+ C V SG +I+W K+ Q++ +G
Sbjct: 3228 SVTLYVNAPEPPQVLQ-ELQPVTVQSGKPARF-CAVISGRPQPKISWYKEEQLLSTGFKC 3285
Query: 704 TIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIY 763
+L + + YTC A N + L V VP VV P+ + +Y
Sbjct: 3286 KFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPE--VVSPDQEMPVY 3343
Query: 764 ---------------GKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILP 808
G+ C V G KV W P ++ + Q
Sbjct: 3344 PPAIITPLQDTVTSEGQPARFQCRVSG-TDLKVSWYSKDKKIKPSRFFRMT-----QFED 3397
Query: 809 NSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIK------ 862
L I ED G Y ASN VG +S + L+++ P I H I+
Sbjct: 3398 TYQLEIAEAYPEDEGTYTFVASNAVG-QVSSTANLSLEAPESIL-HERIEQEIEMEMKAA 3455
Query: 863 --------------GHAKELNCTARGERPIIIRWEK-GDTVIDPDRVMRYAIATKDNGDE 907
GH + C + + +W K G + + D+ +
Sbjct: 3456 PVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKC-------SIRSSK 3508
Query: 908 VVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDP 950
+S+L++ D ++C A N YG LTV E P
Sbjct: 3509 YISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPP 3551
Score = 70.5 bits (171), Expect = 2e-11
Identities = 136/616 (22%), Positives = 230/616 (37%), Gaps = 91/616 (14%)
Query: 773 VDGYPPPKVMW-KHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN 831
V G P P + W K K ++ IQ LP L I+ + D G Y+ A N
Sbjct: 17932 VKGRPEPDITWTKEGKVLVREKR------VDLIQDLPRVELQIKEAVRADHGKYIISAKN 17985
Query: 832 GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP 891
G ++ + P P + + KE NCT E P+ + G + I
Sbjct: 17986 SSGHAQGSAIVNVLDRPG-----PCQNLKVTNVTKE-NCTISWENPL----DNGGSEI-T 18034
Query: 892 DRVMRYAIATKDNGDEVVS--TLKLKPAD--RGDSVFFSCHAINSYGEDRGLIQLT---- 943
+ ++ Y + V S T +L A+ + +F A N G + T
Sbjct: 18035 NFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILA 18094
Query: 944 ---VQEPPDPPELEIREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNK-SDSWDFKQSTR 998
+ P +P L I + + L+W + +DG S + +E + K SD W+
Sbjct: 18095 INPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWE------ 18148
Query: 999 NISPTINQANIVDLH-------PASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPM 1051
+++ +I + H +Y R+ + N+ G S+ K + +E P +
Sbjct: 18149 ----RVHKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDL-QKPVL 18203
Query: 1052 DVTLQPVTSQSIQVTWKAPKKELQNGVIRGY---QIGYRENSPGSNGQYS-IVEMKATGD 1107
D+ L V +T KA +RG ++ + ++ ++ S V++ D
Sbjct: 18204 DLKLSGV------LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRAD 18257
Query: 1108 SEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVA 1167
S ++L K+ VV A N AG+ + + +N D P P N++ + ++SD
Sbjct: 18258 SSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVL---DKPG-PVRNLKIVDVSSDRC 18313
Query: 1168 VISWSEPPRSTLNGVLKGY-------RVIFWSLYVDGEWGEMQNITTTRERVELRGMEKF 1220
+ W +PP ++ Y + + WS Y + T + + +
Sbjct: 18314 TVCW-DPPEDDGGCEIQNYILEKCETKRMVWSTY---------SATVLTPGTTVTRLIEG 18363
Query: 1221 TNYSVQVLAYTQAGDG--VRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPN 1278
Y +V A + G G S + +TK D PG P + S + V W PP
Sbjct: 18364 NEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNPPEYDG 18423
Query: 1279 G-VIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSS 1337
G I Y + S + P PE+ ++ +L +Y V A G G S
Sbjct: 18424 GKSITGYFLEKKEKHSTRWVPVNKSAIPERRM-KVQNLLPDHEYQFRVKAENEIGIGEPS 18482
Query: 1338 -------EKVTIEPAG 1346
K IEP G
Sbjct: 18483 LPSRPVVAKDPIEPPG 18498
Score = 67.8 bits (164), Expect = 1e-10
Identities = 122/591 (20%), Positives = 223/591 (37%), Gaps = 55/591 (9%)
Query: 769 LNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQ 828
L V G P P+V W K + + + V + R +S + D G Y+
Sbjct: 18221 LEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRAD---SSKFSLTKAKRSDGGKYVVT 18277
Query: 829 ASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTV 888
A+N G+ ++ + + P + + ++ CT + P + D
Sbjct: 18278 ATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSD------RCTVCWDPP------EDDGG 18325
Query: 889 IDPDRVMRYAIATKDNGDEVVSTLKLKPAD------RGDSVFFSCHAINSYG-----EDR 937
+ + TK S L P G+ F A N G E +
Sbjct: 18326 CEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTESK 18385
Query: 938 GLIQLTVQEPP---DPPELEIREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNKSDSWDF 993
+I T + P DPPE + +V M + W +DG ITG+ +E K K S +
Sbjct: 18386 PVIAKTKYDKPGRPDPPE--VTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKH-STRW 18442
Query: 994 KQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPS--KELTISTEEAAPDGPPM 1051
++ P + + +L P Y R+ + N+IG EPS ++ + P GPP
Sbjct: 18443 VPVNKSAIPE-RRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPT 18501
Query: 1052 DVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGD--SE 1109
+ + T SI + W P + I GY + R ++ A +
Sbjct: 18502 NFRVVDTTKHSITLGWGKPVYD-GGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRK 18560
Query: 1110 VYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVI 1169
+T+ +L + +Y V A N+ G G + A +++ +PPE S+ + ++
Sbjct: 18561 EFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEI-LEPPEIDLDASMRK-LVIV 18618
Query: 1170 SWSEPPRSTLNGVLKGY---RVIFWSLYVDGEWGEMQ-NITTTRERVELRGMEKFTNYSV 1225
P R L +++G +V + + +D + Q ++ T + + + +
Sbjct: 18619 RAGCPIR--LFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKY 18676
Query: 1226 QVLAYTQAGDGVRSSVLYIQTKE-DVPGPPAGIKAVPSSASSVVVSWLPPTKPNG-VIRK 1283
+ AG+ +++ + D PGP + +K + +S VSW PP G +
Sbjct: 18677 SLTLVNPAGE----KAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTH 18732
Query: 1284 YTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRG 1334
Y + + + S ++ + + +L G +Y V AV G G
Sbjct: 18733 YIV--EKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPG 18781
Score = 67.0 bits (162), Expect = 2e-10
Identities = 101/451 (22%), Positives = 179/451 (39%), Gaps = 58/451 (12%)
Query: 916 PADRGDSVFFSCHAINSYG-------EDRGLIQLTVQEPPDPPELEIREVKARSMNLRWT 968
P G F A N+ G ED L + T P P L + +V R ++L+W
Sbjct: 14146 PLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWE 14205
Query: 969 Q-RFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNK 1027
+ DG I + IE K + + + ++ + P N + D+ + ++ + N+
Sbjct: 14206 PPKNDGGRPIQRYVIEKKERLGT-RWVKAGKTAGPDCN-FRVTDVIEGTEVQFQVRAENE 14263
Query: 1028 IGRSEPSKELTISTEE--AAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIG 1085
G PS+ I + E +P PP+D+ + + I + WK P+K + +I GY +
Sbjct: 14264 AGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPII-GYHV- 14321
Query: 1086 YRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATT 1145
E P ++ V + D + + + +Y + V+A N G SEI+
Sbjct: 14322 --EMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVS-EPSEIS--- 14375
Query: 1146 LEDVPSQPPENVRALSI-TSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQN 1204
E+V ++ P+ + + T D+ VI E + ++ + V S + DG+
Sbjct: 14376 -ENVVAKDPDCKPTIDLETHDIIVI---EGEKLSIPVPFRAVPVPTVSWHKDGK------ 14425
Query: 1205 ITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSV-LYIQTKED-------------- 1249
E++ ++ T + + A+ + VR+ +Y T E+
Sbjct: 14426 --------EVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVI 14477
Query: 1250 -VPGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQ 1307
+PGP IKA + SS ++W PP G I Y + G P + +
Sbjct: 14478 GLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP--VMSGENK 14535
Query: 1308 LFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE 1338
L + + L +Y V AV G G E
Sbjct: 14536 LSWTVKDLIPNGEYFFRVKAVNKVGGGEYIE 14566
Score = 63.5 bits (153), Expect = 2e-09
Identities = 90/406 (22%), Positives = 161/406 (39%), Gaps = 71/406 (17%)
Query: 483 EQFSLMCAAKGAPPPTVTWALD--DEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDG 540
E+ S M A++ P + ++ ++R HR +T+ +M V+ +I G
Sbjct: 31489 ERKSRMTASEALQHPWLKQKIERVSTKVIRTLKHRRYYHTLIKKDL--NMVVSAARISCG 31546
Query: 541 GVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYS-IKWY 599
G R ++ V A+ + GP S + M + G + C++ Y + + WY
Sbjct: 31547 GAIR--SQKGVSVAKVKVASIEIGPVSGQIMHAVGEEGGHVKYV-CKIENYDQSTQVTWY 31603
Query: 600 KDALLLPDNHR-QVVFENGT--LKLTDVQKGMDEGEYLCSVLIQ-------PQLSI---- 645
L ++ + ++ +E+G L + D+ K +D+G Y C V+ +L +
Sbjct: 31604 FGVRQLENSEKYEITYEDGVAILYVKDITK-LDDGTYRCKVVNDYGEDSSYAELFVKGVR 31662
Query: 646 -----------------SQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRI 688
+ ++ + + P P A +G+ + ++ P +
Sbjct: 31663 EVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEP-HV 31721
Query: 689 TWRKDGQVIISGSG---VTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLI 745
TW K GQ I G T ES + + L I+SV+ + YT +A N S + +L
Sbjct: 31722 TWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLT 31781
Query: 746 VRVPP------------RFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQ 793
V + P R + Q+G ++ V G PPP + W+ +
Sbjct: 31782 VTLHPPPTDSTLRPMFKRLLANAECQEG---QSVCFEIRVSGIPPPTLKWE--------K 31830
Query: 794 QYHPVPLTGRIQILPNS----SLLIRHVLEEDIGYYLCQASNGVGT 835
P+ L I+I+ +L IR L ED GYY A+N G+
Sbjct: 31831 DGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGS 31876
Score = 63.2 bits (152), Expect = 3e-09
Identities = 139/686 (20%), Positives = 244/686 (35%), Gaps = 74/686 (10%)
Query: 246 DVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD----PAE-SIPTILDGFHSQEVWAG 300
+ +KE T + T+ K E+R S+T+ P E + P + Q++ G
Sbjct: 1037 EFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEG 1096
Query: 301 HTVELPCTASGYPIPAIRWLKDGRPLPADSRWT---KRITG---LTISDLRTEDSGTYIC 354
+V C G P P + W K G PL R+ + TG L IS +D+G Y
Sbjct: 1097 GSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTI 1156
Query: 355 EVTNTFGSAEATGILMVIDPLHVTLTPKK---LKTGIGSTVILSCALTGSPEFTIRWYRN 411
V N G A+ L+ + + ++ +T + + V +P F Y
Sbjct: 1157 VVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEK 1216
Query: 412 TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAI------IALED 465
++A+ + ++ +T+++ + + F R + + I + ED
Sbjct: 1217 E--YEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEED 1274
Query: 466 GTPR----------IVSSFSEKVVN----PGEQFSLMCAAKGAPPPTVTWALDDEPIVRD 511
G + + S F ++ N G + C G P P + W D + I
Sbjct: 1275 GEEKMAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKH- 1333
Query: 512 GSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAM 571
R + DG + V P+ D G+Y A N+ G+A ++ V + A
Sbjct: 1334 -GERYQMDFLQDGRASLRIPVVLPE--DEGIYTAFASNIKGNAICSGKLYVEPAAPLGAP 1390
Query: 572 RNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEG 631
T + + + R + S + + R +++ ++ +
Sbjct: 1391 ---TYIPTLEPVSRIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETD 1447
Query: 632 EYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWR 691
E L +P +++P F GQ V MP W
Sbjct: 1448 ESQLERLYKPVF--------------VLKPVSFKCLE-GQTARFDLKVVGRPMP-ETFWF 1491
Query: 692 KDGQVIISGSGVTIESKE-FMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIV---- 746
DGQ I++ + KE SL I + +G +T +A N A S L V
Sbjct: 1492 HDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVE 1551
Query: 747 -RVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQ 805
+V P FV + N + G + G P P ++W P +Y + + G
Sbjct: 1552 HQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEG--- 1608
Query: 806 ILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHA 865
++L I + +D +Y A N G D ++ + V++ I +G
Sbjct: 1609 TKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCK-VNVEVEFAEPEPERKLIIPRGTY 1667
Query: 866 KELNCTARGERPIIIR-----WEKGD 886
+ A P+ +R WE+GD
Sbjct: 1668 RAKEIAAPELEPLHLRYGQEQWEEGD 1693
Score = 63.2 bits (152), Expect = 3e-09
Identities = 99/471 (21%), Positives = 163/471 (34%), Gaps = 48/471 (10%)
Query: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRW----TKRITGLTI 341
P I S V G P ++W +G L S+ T + L I
Sbjct: 32374 PRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEI 32433
Query: 342 SDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGS 401
D T+DSGTY TN G A L V + T ++ + +V LT +
Sbjct: 32434 LDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPE--LTRT 32491
Query: 402 PEFTIRWYRNT-ELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAI 460
+ + ++ T E+ ++ ET S+ + + A A + ++ ++ +
Sbjct: 32492 EAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKST 32551
Query: 461 IALEDGT--PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHR--T 516
T RI++ V GE C G P PTVTW + + H+ T
Sbjct: 32552 TRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTT 32611
Query: 517 NQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITA 576
+Y S ++ Q D G Y N G E + + ++ +A A
Sbjct: 32612 TKYK-------STFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQ-----KARVTEKA 32659
Query: 577 VAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCS 636
V + + ++K K +H + V T K T +K
Sbjct: 32660 VTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTET-KPTPTEKVQ-------- 32710
Query: 637 VLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIR-ITWRKDGQ 695
H+ V PP I F AS ++ + CVV S + + +TW KDG+
Sbjct: 32711 -------------HLPVSAPPKITQFLKAEAS-KEIAKLTCVVESSVLRAKEVTWYKDGK 32756
Query: 696 VIISGSGVTIE-SKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLI 745
+ S + L+I++++ G Y C S T Q +
Sbjct: 32757 KLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFM 32807
Score = 61.2 bits (147), Expect = 1e-08
Identities = 60/194 (30%), Positives = 88/194 (45%), Gaps = 23/194 (11%)
Query: 1444 PDQPRLTVSKTSASSITLTWIPGD-NGGSSIRGFVLQYSVDNSEEWKDVFISS-SERSFK 1501
PD P +T K S +T+ W P + +GG SI G+ L+ +S W V S+ ER K
Sbjct: 18399 PDPPEVT--KVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERRMK 18456
Query: 1502 LDSLKCGTWYKVKLAAKNSVGSGRIS---EIIEAKTHGREPSFSKDQHLFTHINSTHARL 1558
+ +L Y+ ++ A+N +G G S + AK P + F +++T +
Sbjct: 18457 VQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTN---FRVVDTTKHSI 18513
Query: 1559 NLQGWN----NGGCPITAIVLEYRPKGTWA-----WQGLRANSS---GEVFLTELREATW 1606
L GW +GG PI V+E RPK A W+ A + E +T L E
Sbjct: 18514 TL-GWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQE 18572
Query: 1607 YELRMRACNSAGCG 1620
YE R+ A N G G
Sbjct: 18573 YEFRVCAQNQVGIG 18586
Score = 60.5 bits (145), Expect = 2e-08
Identities = 54/191 (28%), Positives = 89/191 (46%), Gaps = 14/191 (7%)
Query: 1443 PPDQPRLTVSKTSASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEW-KDVFISSSERSF 1500
PP P+ V + S++ +TW +P ++GGS + G+ L+Y +S W K I ++
Sbjct: 25589 PPGTPK--VVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQM 25646
Query: 1501 KLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNL 1560
K+ L G Y+ ++ A+N G G+ S+ E R+P Q T+I L
Sbjct: 25647 KVSGLDEGLMYEYRVYAENIAGIGKCSKSCEP-VPARDPCDPPGQPEVTNITRKSVSLK- 25704
Query: 1561 QGWN----NGGCPITAIVLEYRPKGTWAWQGLRANSSGEVF--LTELREATWYELRMRAC 1614
W+ +GG IT ++E R W + E + +TEL E YE R+ A
Sbjct: 25705 --WSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFAR 25762
Query: 1615 NSAGCGNETAQ 1625
N+A +E ++
Sbjct: 25763 NAADSVSEPSE 25773
Score = 59.7 bits (143), Expect = 3e-08
Identities = 65/257 (25%), Positives = 108/257 (42%), Gaps = 14/257 (5%)
Query: 1377 PAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIV 1436
P +W K++E P+S + + K D G Y N G +
Sbjct: 13027 PKAEAEWFKENE----PLSTKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFI 13082
Query: 1437 NL-LVQVPPDQPRLTVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVDNSEEWKDVFIS 1494
NL ++ VP L V++T ++L W P +GGS I G+V++ + W
Sbjct: 13083 NLKVIDVPGPVRNLEVTETFDGEVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDR 13142
Query: 1495 SSERSFKLDSL-KCGTWYKVKLAAKNSVGSGRISEI---IEAKTHGREPSFSKDQHLFTH 1550
+ F + L K G Y +++A+N VG+G E +EA++ P + + T
Sbjct: 13143 AESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTI-TD 13201
Query: 1551 INSTHARLNLQGWN-NGGCPITAIVLEYRPKGTWAWQGLRANSSGEVF--LTELREATWY 1607
+N L + +GG IT V+E R K + W + ++ +T++ E Y
Sbjct: 13202 VNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEY 13261
Query: 1608 ELRMRACNSAGCGNETA 1624
R+RA N G G +A
Sbjct: 13262 SFRVRAQNRIGVGKPSA 13278
Score = 58.9 bits (141), Expect = 5e-08
Identities = 88/437 (20%), Positives = 159/437 (36%), Gaps = 36/437 (8%)
Query: 813 LIRHVLEEDIGYYLCQASNGVGTDISK-SMFLTVKIPAMITS------HPNTTIAIKGHA 865
++R++ E + + A N G + S + VK M+ + IA G
Sbjct: 21023 VVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDN 21082
Query: 866 KELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFF 925
++ G + W+KGD ++ + + + + L + R DS +
Sbjct: 21083 IKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATS------TILNINECVRSDSGPY 21136
Query: 926 SCHAINSYGEDRGLIQLTVQEPPDPP--ELEIREVKARSMNLRW-TQRFDGNSIITGFDI 982
A N GE +I + V + P PP ++ EV + + W DG I+ + +
Sbjct: 21137 PLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVV 21196
Query: 983 EYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEP-SKELTIST 1041
E + ++DS + + + T +A L Y R+ + N+ G + ++
Sbjct: 21197 EMR-QTDSTTWVELATTVIRTTYKA--TRLTTGLEYQFRVKAQNRYGVGPGITSACIVAN 21253
Query: 1042 EEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVE 1101
GPP + VT S+ ++W P + I GY + +E NG
Sbjct: 21254 YPFKVPGPPGTPQVTAVTKDSMTISWHEPLSD-GGSPILGYHVERKER----NGILWQTV 21308
Query: 1102 MKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALS 1161
KA ++ L Y V A N AG S D P PP L+
Sbjct: 21309 SKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALD-PIDPPGKPVPLN 21367
Query: 1162 ITSDVAVISWSEPPRSTLNGVLKGYRVIFWSL----YVDGEWGEMQNITTTRERVELRGM 1217
IT + W++P + G+++ + + +G W + + G+
Sbjct: 21368 ITRHTVTLKWAKPEYT------GGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGL 21421
Query: 1218 EKFTNYSVQVLAYTQAG 1234
+ Y +V+A AG
Sbjct: 21422 TEDAAYEFRVIAKNAAG 21438
Score = 58.2 bits (139), Expect = 9e-08
Identities = 55/209 (26%), Positives = 87/209 (41%), Gaps = 13/209 (6%)
Query: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT------GL 339
PT S V G T SG+P+P + W +DG+ + + +I+ L
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 340 TISDLRTEDSGTYICEVTNTFGSAEATGILMV---IDPLHVTLTPKKLKTGIGSTVILSC 396
TI + +SG Y + TN G A +T L+V P + + + GS V L
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQV 125
Query: 397 ALTGSPEFTIRWYRNTELVLP--DEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQT 454
+TG P +++YR+ + D IS G +LLI A SG Y AT
Sbjct: 126 RVTGIPTPVVKFYRDGAEIQSSLDFQISQEG-DLYSLLIAEAYPEDSGTYSVNATNSVGR 184
Query: 455 AQDFAIIALEDGTPRIVSSFSEKVVNPGE 483
A A + L G + + ++ +V+ +
Sbjct: 185 ATSTAEL-LVQGEEEVPAKKTKTIVSTAQ 212
Score = 57.8 bits (138), Expect = 1e-07
Identities = 49/196 (25%), Positives = 75/196 (38%), Gaps = 12/196 (6%)
Query: 389 GSTVILSCALTGSPEFTIRWYRNTELV----LPDEAISIRGLSNETLLITSAQKSHSGAY 444
GST ++G P + W+R+ +++ LP IS L I + K++SG Y
Sbjct: 20 GSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSD-GRAKLTIPAVTKANSGRY 78
Query: 445 QCFATRKAQTAQDFA--IIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
AT + A A ++ E P V V G Q L G P P V +
Sbjct: 79 SLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFY 138
Query: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562
D I + + +S + + + D G Y A N VG A A + V
Sbjct: 139 RDGAEI-----QSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLV 193
Query: 563 RGPPSIRAMRNITAVA 578
+G + A + T V+
Sbjct: 194 QGEEEVPAKKTKTIVS 209
Score = 57.4 bits (137), Expect = 1e-07
Identities = 149/704 (21%), Positives = 253/704 (35%), Gaps = 105/704 (14%)
Query: 715 QISSVSLKHNGNYTC-IASNAAATVSRERQLIVRVPPRFVVQPNNQDG-------IYGKA 766
+ + SL N Y + + + R +L + P+ +++P D + +A
Sbjct: 18561 EFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRA 18620
Query: 767 GV---LNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPL--TGRIQILPNSSLLIRHVLEED 821
G L V G P PKV W+ G N + V L T ++PNS+ +D
Sbjct: 18621 GCPIRLFAIVRGRPAPKVTWRKV-GIDNVVRKGQVDLVDTMAFLVIPNST-------RDD 18672
Query: 822 IGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIR 881
G Y N G K++F+ V++ + G +L + + +
Sbjct: 18673 SGKYSLTLVNPAG---EKAVFVNVRV-----------LDTPGPVSDLKVSDVTKTSCHVS 18718
Query: 882 WEKGDTVIDPDRVMRYAIATKDNGDEVVSTL--KLKPAD-------RGDSVFFSCHAINS 932
W + +V Y + ++ + ST+ ++K G+ +F A+N
Sbjct: 18719 WAPPEND-GGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNE 18777
Query: 933 YGEDRG-------LIQLTVQEPPDPPELEIREVKARSMNLRWTQRF-DGNSIITGFDIEY 984
YG L + EP P +LE+ E+ S L W DG + I G+ Y
Sbjct: 18778 YGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSY 18837
Query: 985 KNK---SDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTIST 1041
+ + +D W +++S + L Y R+ + N +G S P
Sbjct: 18838 REEEQPADRWTEYSVVKDLSLV-----VTGLKEGKKYKFRVAARNAVGVSLP-------- 18884
Query: 1042 EEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRG-------YQIGYRENSPGSN 1094
EA + L P Q+T KA KK + G ++ G E S+
Sbjct: 18885 REAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSH 18944
Query: 1095 GQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPP 1154
+ KA S + D +K + Y + A N +GT ++ + D P P
Sbjct: 18945 ----LAVHKADSSSILIIKDVTRKDSGY-YSLTAENSSGTDTQKIKV---VVMDAPGPPQ 18996
Query: 1155 ENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEW-GEMQNITTTRERVE 1213
I +D +SW P + + ++ G+W + ++T T RV
Sbjct: 18997 PPFDISDIDADACSLSWHIPLEDGGSNITN--YIVEKCDVSRGDWVTALASVTKTSCRVG 19054
Query: 1214 --LRGMEKFTNYSVQVLAYTQAG--DGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVV 1269
+ G E Y +V A + G + + S + Q VP P + + + V
Sbjct: 19055 KLIPGQE----YIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFV 19110
Query: 1270 SWLPPTKPNG-VIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAV 1328
+W P G I Y I S + +T Y A L G +Y + A+
Sbjct: 19111 AWDRPDSDGGSPIIGYLIERKERNSLLWVKAN-DTLVRSTEYPCAGLVEGLEYSFRIYAL 19169
Query: 1329 TSAGRGNSSE-------KVTIEPAGKAPAKIISFGGTVTTPWMK 1365
AG S+ ++ ++P GK P I TV+ W +
Sbjct: 19170 NKAGSSPPSKPTEYVTARMPVDPPGK-PEVIDVTKSTVSLIWAR 19212
Score = 57.0 bits (136), Expect = 2e-07
Identities = 77/348 (22%), Positives = 143/348 (41%), Gaps = 35/348 (10%)
Query: 920 GDSVFFSCHAINSYGE-DRGLIQ--LTVQEPPDPPELEIREVKARSMNLRWTQRFDGNSI 976
G + F A+N+ GE D + + V++ +PPEL + AR +++ ++I
Sbjct: 17182 GQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAI 17241
Query: 977 ITGFDIEYKN-KSDSWDFKQSTR-NISPTINQANIVDL--HPASVYSIRMYSFNKIGRSE 1032
I G K + D R +++P ++ I + +YS+ +
Sbjct: 17242 IKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTV--------EN 17293
Query: 1033 PSKELTISTEEAAPD--GPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENS 1090
P+ T+S + D GPP D+ + + S +TWK P + VI Y + E
Sbjct: 17294 PAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDD-GGSVITNYVV---ERR 17349
Query: 1091 PGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDV- 1149
++ Q+S + AT + + +L + QY V A N+ G GP D
Sbjct: 17350 DVASAQWS--PLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPL 17407
Query: 1150 -PSQPPENVRALSITSDVAVISWSEPPR---STLNGVLKGYRVIFWSLYVDGEWGEMQNI 1205
P PP+++ + + + W++P R S + G L Y+ +G ++
Sbjct: 17408 HPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQ-------EEGTQDWIKFK 17460
Query: 1206 TTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGP 1253
T T + G+++ Y +V A G G+ + + I+ +E + P
Sbjct: 17461 TVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPP 17508
Score = 55.8 bits (133), Expect = 4e-07
Identities = 50/198 (25%), Positives = 80/198 (40%), Gaps = 11/198 (5%)
Query: 651 VAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGS--GVTIESK 708
+ + P QP + G +S +P ++W +DGQVI + + GV I
Sbjct: 1 MTTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVP-EVSWFRDGQVISTSTLPGVQISFS 59
Query: 709 EFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV---PPRFVVQPNNQDGIYGK 765
+ + L I +V+ ++G Y+ A+N + + +L+V+ PP FV + + G
Sbjct: 60 DGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGS 119
Query: 766 AGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYY 825
L V G P P V + + G + SLLI ED G Y
Sbjct: 120 QVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLY-----SLLIAEAYPEDSGTY 174
Query: 826 LCQASNGVGTDISKSMFL 843
A+N VG S + L
Sbjct: 175 SVNATNSVGRATSTAELL 192
Score = 55.1 bits (131), Expect = 7e-07
Identities = 92/394 (23%), Positives = 144/394 (36%), Gaps = 43/394 (10%)
Query: 571 MRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVV--FENGTLKLT-DVQKG 627
++N + G +C++ GYP I WYKD + R + ++G L V
Sbjct: 1297 IKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLP 1356
Query: 628 MDEGEYLCSVL-IQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPI 686
DEG Y I+ S ++V P A +G YIP + +
Sbjct: 1357 EDEGIYTAFASNIKGNAICSGKLYVE------------PAAPLGAPTYIPTLEPVSRI-- 1402
Query: 687 RITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIV 746
R +S S + + S MS ++S + ++ + E QL
Sbjct: 1403 ----RSLSPRSVSRSPIRM-SPARMSPARMSPARMSP----ARMSPGRRLEETDESQLER 1453
Query: 747 RVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQI 806
P FV++P + + G+ + V G P P+ W H H V I+
Sbjct: 1454 LYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVV----IKE 1509
Query: 807 LPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI------PAMITSHPNTTIA 860
SL+I D G + A N G S S+ LTV+ P + N I
Sbjct: 1510 DGTQSLIIVPATPSDSGEWTVVAQNRAGRS-SISVILTVEAVEHQVKPMFVEKLKNVNIK 1568
Query: 861 IKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRG 920
+G E+ A G I W K +I P + + I G + + LK+
Sbjct: 1569 -EGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRI----EGTKGEAALKIDSTVSQ 1623
Query: 921 DSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELE 954
DS +++ AIN G D ++ V+ PE E
Sbjct: 1624 DSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPE 1657
Score = 54.3 bits (129), Expect = 1e-06
Identities = 62/266 (23%), Positives = 93/266 (34%), Gaps = 48/266 (18%)
Query: 339 LTISDLRTEDSGTYICEVTNTFGSAEATGILMV-----IDPLHVTLTPKKLKTG------ 387
L + D+ D GTY C+V N +G + L V + + T KK+K
Sbjct: 31626 LYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRL 31685
Query: 388 -----------------IGSTVILSCALTGSPEFTIRWYRNTELVLPDEAI------SIR 424
+G V +T PE + WY++ + + P + S +
Sbjct: 31686 LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDK 31745
Query: 425 GLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSS----FSEKVVN 480
GL L I S Y A K A + + P S+ F + N
Sbjct: 31746 GLYQ--LTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLAN 31803
Query: 481 P----GEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQ 536
G+ G PPPT+ W D +P+ S N + +G +++
Sbjct: 31804 AECQEGQSVCFEIRVSGIPPPTLKWEKDGQPL----SLGPNIEIIHEGLDYYALHIRDTL 31859
Query: 537 IRDGGVYRCTARNLVGSAEYQARINV 562
D G YR TA N GS QA + V
Sbjct: 31860 PEDTGYYRVTATNTAGSTSCQAHLQV 31885
Score = 53.9 bits (128), Expect = 2e-06
Identities = 102/496 (20%), Positives = 183/496 (36%), Gaps = 56/496 (11%)
Query: 297 VWAGHTVELPCTASGYPIPAIRWLKDGRPLPADS---RWTKRITGLTISDLRTEDSGTYI 353
V AG T C S IP +LK + P+D R ++ LT+ D++ ED+G
Sbjct: 12207 VTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAG--- 12263
Query: 354 CEVTNTFGSAEATGILMVID-PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN- 411
EV T + L V + P+ T + G+T +L C ++ ++W++N
Sbjct: 12264 -EVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVS-RENAKVKWFKNG 12321
Query: 412 TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTP--- 468
TE++ + + L+I Y C A+DF + P
Sbjct: 12322 TEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTC-------DAKDFKTSCNLNVVPPHV 12374
Query: 469 RIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTIS 528
+ ++ V E C V W D I + +Y + +
Sbjct: 12375 EFLRPLTDLQVREKEMARFECEL-SRENAKVKWFKDGAEI-----KKGKKYDIISKGAVR 12428
Query: 529 HMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI--RAMRNITAVAGRDTLINC 586
+ + + D Y C R +A + V ++ + + NI V+ DT+
Sbjct: 12429 ILVINKCLLDDEAEYSCEVR----TARTSGMLTVLEEEAVFTKNLANI-EVSETDTIKLV 12483
Query: 587 RVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKG--MDEGEYLCSVLIQPQLS 644
+ P + WYK + + R + G ++ +Q D G Y C +
Sbjct: 12484 CEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRL------- 12536
Query: 645 ISQSVHVAVKVPPLIQPFEFPPASI----GQLLYIPCVVSSGDMPIRITWRKDGQVIISG 700
S VKV L F P ++ G+ C +S P++ W++D + + SG
Sbjct: 12537 PSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFPVQ--WKRDDKTLESG 12594
Query: 701 SGVTIESKEFMSSLQISSVSLKHNGNYTCI--ASNAAATVSRERQLIVRVPPRFVVQPNN 758
+ + L + +L+ G Y + A+ AAA ++ +L + VP +
Sbjct: 12595 DKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIEKLRIVVPLKDTRVKEQ 12654
Query: 759 QDGIYGKAGVLNCSVD 774
Q+ ++ NC V+
Sbjct: 12655 QEVVF------NCEVN 12664
Score = 53.5 bits (127), Expect = 2e-06
Identities = 64/292 (21%), Positives = 105/292 (35%), Gaps = 68/292 (23%)
Query: 560 INVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDN-HRQVVFENGT 618
I V P + ++N+T + G + C + GYP ++ WY++ + + Q+ F++G
Sbjct: 938 IPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGI 997
Query: 619 LKLTDVQK-GMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPC 677
+L + D G + CS + ++S S ++AV+V + FE ++ +
Sbjct: 998 ARLMIREAFAEDSGRFTCSA-VNEAGTVSTSCYLAVQVS---EEFEKETTAVTEKF---- 1049
Query: 678 VVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAAT 737
T E K F+ S + AA
Sbjct: 1050 --------------------------TTEEKRFVESRDVVMTDTSLTEEQAGPGEPAA-- 1081
Query: 738 VSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHP 797
P F+ +P Q + G + V C V G P P V WK +
Sbjct: 1082 ------------PYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKS----------G 1119
Query: 798 VPLTG--RIQILPNS-----SLLIRHVLEEDIGYYLCQASNGVG-TDISKSM 841
VPLT R ++ N L+I +D G Y N G T S S+
Sbjct: 1120 VPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171
Score = 52.0 bits (123), Expect = 6e-06
Identities = 152/722 (21%), Positives = 265/722 (36%), Gaps = 82/722 (11%)
Query: 655 VPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSL 714
+PP I E G+ L I V P W+K +++ S + + + S L
Sbjct: 18898 LPPKILMPEQITIKAGKKLRIEAHVYGKPHPT-CKWKKGEDEVVTSSHLAVHKADSSSIL 18956
Query: 715 QISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVD 774
I V+ K +G Y+ A N++ T +++ +++V P P + I A CS+
Sbjct: 18957 IIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADA----CSLS 19012
Query: 775 GYPPPKVMWKHAKGSGNPQQY-------HPVPLTGRIQILPNSSLLIRHVLEEDIGYYLC 827
+ P + G N Y + + +S + ++ +
Sbjct: 19013 WHIPLE------DGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRV 19066
Query: 828 QASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDT 887
+A N G IS+ + P M+ P + K T + I + W++ D+
Sbjct: 19067 RAENRFG--ISEPL----TSPKMVAQFP---FGVPSEPKNARVTKVNKDCIFVAWDRPDS 19117
Query: 888 VIDPDRVMRYAIATKDN--------GDEVVSTLKLKPAD--RGDSVFFSCHAINSYGE-- 935
++ Y I K+ D +V + + A G F +A+N G
Sbjct: 19118 -DGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSP 19176
Query: 936 -DRGLIQLTVQEPPDPP-ELEIREVKARSMNLRWTQ-RFDGNSIITGFDIE-YKNKSDSW 991
+ +T + P DPP + E+ +V +++L W + + DG S I G+ +E K D W
Sbjct: 19177 PSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKW 19236
Query: 992 DFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIG---RSEPSKELTISTEEAAPDG 1048
+ + P + L + Y R + + SEPS +TI E
Sbjct: 19237 VRCNTAPHQIPQ-EEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAENVP--- 19292
Query: 1049 PPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDS 1108
P +D++ V +S+ +T KA + + G + +K
Sbjct: 19293 PRIDLS---VAMKSL-LTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQR 19348
Query: 1109 EVYTLD----NLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITS 1164
+ TL+ N K Y + + +G S+ I L D P PP +V+ + S
Sbjct: 19349 NLCTLELFSVNRKDSGDYTITAE----NSSGSKSATIKLKVL-DKPG-PPASVKINKMYS 19402
Query: 1165 DVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQ---NITTTRERVELRGMEKFT 1221
D A++SW EPP + Y ++ W ++ IT+ + G E
Sbjct: 19403 DRAMLSW-EPPLEDGGSEITNY-IVDKRETSRPNWAQVSATVPITSCSVEKLIEGHE--- 19457
Query: 1222 NYSVQVLAYTQ--AGDGVRSSVLYIQTKEDVPG--PPAGIKAVPSSASSVVVSWLPPTKP 1277
Y ++ A + GD V + + D PG P I + + + VSW PP
Sbjct: 19458 -YQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNI--TKDHMTVSWKPPADD 19514
Query: 1278 NG-VIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNS 1336
G I Y + + + E+ + L G +Y V A+ AG G
Sbjct: 19515 GGSPITGYLLEKRETQAVNWTKVNRKPIIERTL-KATGLQEGTEYEFRVTAINKAGPGKP 19573
Query: 1337 SE 1338
S+
Sbjct: 19574 SD 19575
Score = 51.6 bits (122), Expect = 8e-06
Identities = 32/81 (39%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 297 VWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWT----KRITGLTISDLRTEDSGTY 352
V AG +ELP T +G P P I W K L D R T + + +TI D + D+GTY
Sbjct: 13702 VKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTY 13761
Query: 353 ICEVTNTFGSAEATGILMVID 373
I E N G A A + V+D
Sbjct: 13762 IIEAVNVCGRATAVVEVNVLD 13782
Score = 51.2 bits (121), Expect = 1e-05
Identities = 109/545 (20%), Positives = 191/545 (35%), Gaps = 81/545 (14%)
Query: 219 VSWEKDTVSIIPEHRFFITYHGGLY----ISDVQKEDALSTYRCITKHKYSGETRQSNGA 274
V W I P ++ I HG +Y ++ ++ ++ T+ Y+GE S
Sbjct: 2563 VLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTF-------YAGENMTSG-- 2613
Query: 275 RLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTK 334
+L+V A S P Q V C + P WL+DG+ LP +
Sbjct: 2614 KLTVAGGAISKPLT-----DQTVAESQEAVFECEVAN-PDSKGEWLRDGKHLPLTNNIRS 2667
Query: 335 RITG----LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGS 390
G L I+ + +D G Y +V + SA+ + ++ + + T K L
Sbjct: 2668 ESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAK-----LKVEAVKIKKTLKNLTVTETQ 2722
Query: 391 TVILSCALTGSPEFTIRWYRNTELVLPDE--AISIRG------LSNETLLITSAQKSHSG 442
+ + LT ++W +N ++ +E AIS++G + N ++ S G
Sbjct: 2723 DAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLG 2782
Query: 443 AYQCFATRKAQTAQDFA----IIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPT 498
A +T + + ALE+ T S S V
Sbjct: 2783 RLGASARLHVETVKIIKKPKDVTALENATVAFEVSVSHDTV------------------P 2824
Query: 499 VTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQA 558
V W I HR + + + + D G Y +VG E +A
Sbjct: 2825 VKWFHKSVEIKPSDKHR-----LVSERKVHKLMLQNISPSDAGEYTA----VVGQLECKA 2875
Query: 559 RINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGT 618
++ V + M+NI + C V + S+ W K+ + + + + + G
Sbjct: 2876 KLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGK 2934
Query: 619 LKLTDVQKGM--DEGEY--LCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLY 674
L + D EY +C + V + V P++ + +
Sbjct: 2935 LHQLIIMNTSTEDSAEYTFVCG---------NDQVSATLTVTPIMITSMLKDINAEEKDT 2985
Query: 675 IPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNA 734
I V+ I W K+G I S + +K+ SL I +V +YT +A A
Sbjct: 2986 ITFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKA 3045
Query: 735 AATVS 739
+T +
Sbjct: 3046 TSTAT 3050
Score = 50.8 bits (120), Expect = 1e-05
Identities = 85/373 (22%), Positives = 139/373 (37%), Gaps = 70/373 (18%)
Query: 302 TVELPCTASGYPIPAIRWLKD-GRPLP-ADSRWTKRITGLTISDLRTEDSGTYICEVTNT 359
T+ L G P P ++W +D G L A T T L + ++ DSG YI V N+
Sbjct: 21877 TLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENS 21936
Query: 360 FGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPE-FTIRWYRNTELVLPD 418
GS A + V+D TP G P+ ++ T + L
Sbjct: 21937 SGSKSAFVNVRVLD------TP------------------GPPQDLKVKEVTKTSVTLTW 21972
Query: 419 EAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTP---RIVSSFS 475
+ + G S I ++S AY AT +T+ + + L++G R+++
Sbjct: 21973 DPPLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTS--WKVDQLQEGCSYYFRVLAENE 22030
Query: 476 EKVVNPGEQF-SLMCAAKGAPPPTVTW--------ALDDEPIVRDGSHRTNQYTMSDGTT 526
+ P E S+ + + PP +T +L E DG R Y + T
Sbjct: 22031 YGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTK 22090
Query: 527 ISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG---------------------P 565
S T ++ V T L+ EY R++ + P
Sbjct: 22091 GSDKWATCATVK---VTEATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIP 22147
Query: 566 PSIRAMRN-ITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHR---QVVFENGTLKL 621
P+ + + N T +AG D ++ IG P ++ W+KD + L R + N L +
Sbjct: 22148 PAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTI 22207
Query: 622 TDVQKGMDEGEYL 634
D + D G Y+
Sbjct: 22208 KDACR-EDVGHYV 22219
Score = 50.4 bits (119), Expect = 2e-05
Identities = 68/275 (24%), Positives = 103/275 (37%), Gaps = 46/275 (16%)
Query: 305 LPCTASGYPIPAIRWLKDGRPLPAD------SRWTKRITGLTISDLRTEDSGTYICEVTN 358
L C +G+P P ++W + G+ + AD + L I+ + +D+ Y TN
Sbjct: 30947 LVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATN 31006
Query: 359 TFGSAEATGILMVIDPLHVTLTPKKLKTGIGS-------TVILSCALTGSPEFTIRWYRN 411
GS T L V P + L PK L+ G+G+ V + +G P+ I W +
Sbjct: 31007 QGGSVSGTASLEVEVPAKIHL-PKTLE-GMGAVHALRGEVVSIKIPFSGKPDPVITWQKG 31064
Query: 412 TELVLPDEAISIRGLSNETLLI--TSAQKSHSGAYQCFATRKAQTAQDFAIIALED--GT 467
+L+ + + + T L+ ++ +G Y A + Q + + D
Sbjct: 31065 QDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVADVPDP 31124
Query: 468 PR--IVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGT 525
PR VS S VN +TW EP GS TN T
Sbjct: 31125 PRGVKVSDVSRDSVN------------------LTWT---EPASDGGSKITNYIVEKCAT 31163
Query: 526 TISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARI 560
T G Q R+ R T NL G YQ R+
Sbjct: 31164 TAERWLRVG-QARE---TRYTVINLFGKTSYQFRV 31194
Score = 49.7 bits (117), Expect = 3e-05
Identities = 34/108 (31%), Positives = 51/108 (47%), Gaps = 4/108 (3%)
Query: 292 FHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG----LTISDLRTE 347
F++ V AG +++ G P PA+ W KD PL +R T LTI D E
Sbjct: 22154 FNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACRE 22213
Query: 348 DSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILS 395
D G Y+ ++TN+ G A T ++V+D P K+ ++ LS
Sbjct: 22214 DVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLS 22261
Score = 49.3 bits (116), Expect = 4e-05
Identities = 61/229 (26%), Positives = 96/229 (41%), Gaps = 26/229 (11%)
Query: 160 DYFCTAENAAGKIRSPNIRVKAVFREP-YTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218
DY+C K R+ +R+ + R P +T+ + ++ + G F I + +V+
Sbjct: 31666 DYYCRRTMKKIKRRTDTMRL--LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVT- 31722
Query: 219 VSWEKDTVSIIP---EHRFFITYHGGLY---ISDVQKEDALSTYRCITKHKYSGETRQSN 272
W K I P + ++ GLY I+ V +D + Y + ++KY ++ +
Sbjct: 31723 --WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDD-AEYTVVARNKYGEDSCK-- 31777
Query: 273 GARLSVT---DPAESI--PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLP 327
A+L+VT P +S P + E G +V SG P P ++W KDG+PL
Sbjct: 31778 -AKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLS 31836
Query: 328 ADSRWTKRITGLT-----ISDLRTEDSGTYICEVTNTFGSAEATGILMV 371
GL I D ED+G Y TNT GS L V
Sbjct: 31837 LGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQV 31885
Score = 48.5 bits (114), Expect = 7e-05
Identities = 94/395 (23%), Positives = 141/395 (35%), Gaps = 53/395 (13%)
Query: 278 VTDPAESIPTILDG--FHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKR 335
V D E ILD Q + G T+ L G P P + W K+ R P +R
Sbjct: 17209 VKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVT 17268
Query: 336 ITG--LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVI 393
G L I + ED G Y V N GS + ++V+D P+ L+ +
Sbjct: 17269 PVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDK---PGPPRDLE--VSEIRK 17323
Query: 394 LSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQ 453
SC LT T V+ E + L TS +KSH FA +
Sbjct: 17324 DSCYLTWKEPLDDGGSVITNYVV--ERRDVASAQWSPLSATSKKKSH------FAKHLNE 17375
Query: 454 TAQDFAIIALED--------GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDD 505
Q +A E+ TP+ + + + + PG L ++ W D
Sbjct: 17376 GNQYLFRVAAENQYGRGPFVETPKPIKAL-DPLHPPGPPKDLHHVDVDKTEVSLVWNKPD 17434
Query: 506 EPIVRDGSHRTNQYTM---SDGT-------TISHMNVTGPQIRDGGVY--RCTARNLVGS 553
RDG Y + +GT T++++ ++ G Y R A N+VG
Sbjct: 17435 ----RDGGSPITGYLVEYQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGL 17490
Query: 554 AEYQARINVR-----GPPS----IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKD-AL 603
I + PPS ++ + + AG + G P + KW D +
Sbjct: 17491 GLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSE 17550
Query: 604 LLPDNHRQVVFENGTLKLTDVQ-KGMDEGEYLCSV 637
+ D H V +N + LT D GEY +V
Sbjct: 17551 IKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITV 17585
Score = 48.1 bits (113), Expect = 9e-05
Identities = 35/107 (32%), Positives = 51/107 (47%), Gaps = 3/107 (2%)
Query: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTN-GT 1407
P ++S VT + V L C+ G P+P V W + ED I S+D +
Sbjct: 942 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYR--EDYQIESSIDFQITFQSGIAR 999
Query: 1408 LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKT 1454
L++R AEDSG +TC+A N G + L VQV + + T + T
Sbjct: 1000 LMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVT 1046
Score = 48.1 bits (113), Expect = 9e-05
Identities = 122/636 (19%), Positives = 223/636 (35%), Gaps = 69/636 (10%)
Query: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 220
Y T ENA S ++V V R+ + DQ A+F C I +
Sbjct: 11282 YTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIAKDTPN----IK 11337
Query: 221 WEK--DTVSIIPEHRFFITYHGG---LYISDVQKEDALSTYRCITKHKYSGETRQSNGAR 275
W K D + P + I G L I + ED I +Y A+
Sbjct: 11338 WFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYP--------AK 11389
Query: 276 LSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDG---RPLPA---D 329
L++ E +L ++ + S IP +W G RP P
Sbjct: 11390 LTL---GEREVELLKPIEDVTIYEKESASFDAEISEADIPG-QWKLKGELLRPSPTCEIK 11445
Query: 330 SRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVID---PLHVTLTPKKLKT 386
+ KR LT+ ++ + +G + + N +A T + +D PL P++ +
Sbjct: 11446 AEGGKRF--LTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVPERRQA 11503
Query: 387 GIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAIS-IRGLSNETLLITSAQKSHSGAYQ 445
C LT E + W + +++ + I L+I +Q G Y
Sbjct: 11504 R------FECVLT--REANVIWSKGPDIIKSSDKFDIIADGKKHILVINDSQFDDEGVYT 11555
Query: 446 CFATRKAQTAQDFAI-IALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALD 504
K +A+ F I L + +S ++ V GE + +C V W +
Sbjct: 11556 AEVEGKKTSARLFVTGIRL-----KFMSPLEDQTVKEGETATFVCEL-SHEKMHVVWFKN 11609
Query: 505 DEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG 564
D + H + +S + + + D + + L +A Q ++
Sbjct: 11610 DAKL-----HTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTA--QLKVLEAD 11662
Query: 565 PPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDV 624
P + + TAV + + C V +KW+KD + + + + +G ++ +
Sbjct: 11663 PYFTVKLHDKTAVEKDEITLKCEV--SKDVPVKWFKDGEEIVPSPKYSIKADGLRRILKI 11720
Query: 625 QKG--MDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSG 682
+K D+GEY+C +V V ++ + +P +G+ + +S
Sbjct: 11721 KKADLKDKGEYVCDCGTD---KTKANVTVEARLIKVEKPLYGVEVFVGETAHFEIELSEP 11777
Query: 683 DMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRER 742
D + W+ GQ + + I L + + L G + A+NA + +
Sbjct: 11778 D--VHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAAN--- 11832
Query: 743 QLIVRVPPRFVVQPNNQDGIYGK-AGVLNCSVDGYP 777
L V+ P + P + ++ K C V P
Sbjct: 11833 -LKVKELPLIFITPLSDVKVFEKDEAKFECEVSREP 11867
Score = 48.1 bits (113), Expect = 9e-05
Identities = 119/612 (19%), Positives = 224/612 (36%), Gaps = 78/612 (12%)
Query: 303 VELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG----LTISDLRTEDSGTYICEVTN 358
V L C S P ++W KDG+ + + G L + D G Y C+
Sbjct: 12035 VILQCEISKADAP-VKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDC-- 12091
Query: 359 TFGSAEATGILMVID-------PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN 411
G+ + +G L + D PLH ++ + +T T I + W
Sbjct: 12092 --GTDKTSGKLDIEDREIKLVRPLH-SVEVMETETARFETEI------SEDDIHANWKLK 12142
Query: 412 TELVL--PDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPR 469
E +L PD I G + +L++ + + +G +A + A + ++
Sbjct: 12143 GEALLQTPDCEIKEEGKIH-SLVLHNCRLDQTGGVDF----QAANVKSSAHLRVKPRVIG 12197
Query: 470 IVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISH 529
++ + V GE + C P V W L + + +++ +
Sbjct: 12198 LLRPLKDVTVTAGETATFDCELSYEDIP-VEWYLKGKKL-----EPSDKVVPRSEGKVHT 12251
Query: 530 MNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS--IRAMRNITAVAGRDTLINCR 587
+ + ++ D G + TA++ + A + V+ PP + + + T G ++ C
Sbjct: 12252 LTLRDVKLEDAGEVQLTAKDF----KTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECE 12307
Query: 588 VIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEG--EYLCSVLIQPQLSI 645
V +KW+K+ + + + + +G ++ + E Y C
Sbjct: 12308 V-SRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDA---KDFKT 12363
Query: 646 SQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTI 705
S +++V ++P ++ C +S + ++ W KDG I G I
Sbjct: 12364 SCNLNVVPPHVEFLRPLTDLQVREKEMARFECELSRENAKVK--WFKDGAEIKKGKKYDI 12421
Query: 706 ESKEFMSSLQISSVSLKHNGNYTCIASNAAA----TVSRERQLIVRVPPRFVVQPNNQDG 761
SK + L I+ L Y+C A TV E + + ++ + D
Sbjct: 12422 ISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLAN--IEVSETDT 12479
Query: 762 IYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSS---LLIRHVL 818
I L C V P +V+W KG + TGR +IL L+I++
Sbjct: 12480 I-----KLVCEV-SKPGAEVIW--YKGD------EEIIETGRYEILTEGRKRILVIQNAH 12525
Query: 819 EEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPI 878
ED G Y C+ + TD + ++ A S P ++G E C+ E
Sbjct: 12526 LEDAGNYNCRLPSS-RTDGKVKVH---ELAAEFISKPQNLEILEGEKAEFVCSISKE-SF 12580
Query: 879 IIRWEKGDTVID 890
++W++ D ++
Sbjct: 12581 PVQWKRDDKTLE 12592
Score = 48.1 bits (113), Expect = 9e-05
Identities = 35/116 (30%), Positives = 47/116 (40%), Gaps = 19/116 (16%)
Query: 297 VWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG----LTISDLRTEDSGTY 352
V AG TV P G P+P +W DG + D +T LTI + D+G Y
Sbjct: 17522 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEY 17581
Query: 353 ICEVTNTFGSAEATGILMVID---------------PLHVTLTPKKLKTGIGSTVI 393
V+N GS L V+D P H+T++ + K GS VI
Sbjct: 17582 QITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVI 17637
Score = 47.8 bits (112), Expect = 1e-04
Identities = 88/447 (19%), Positives = 156/447 (34%), Gaps = 37/447 (8%)
Query: 468 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTI 527
P+I + V G G P P W + I R S R Y D +
Sbjct: 2078 PKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIER--SDRIYWYWPEDN--V 2133
Query: 528 SHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGR--DTL-- 583
+ + D A N+ G A + V+ I + + V + DT+
Sbjct: 2134 CELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMAT 2193
Query: 584 INCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQ--KGMDEGEYLCSVLIQP 641
C P+ +KWYKD + + + + + + + + D +Y C ++
Sbjct: 2194 FECET-SEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDE 2252
Query: 642 QLSISQSVHV---AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVII 698
+ + + V V+ +Q E P + G+L C+VS + I W + +
Sbjct: 2253 NVKTTAKLIVEGAVVEFVKELQDIEVPESYSGEL---ECIVSPEN--IEGKWYHNDVELK 2307
Query: 699 SGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNN 758
S TI S+ +L + V+ + G Y+ + T + + P +
Sbjct: 2308 SNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMK-----PRPIAILQGL 2362
Query: 759 QDGIYGKAGVLNCSVDGYPPPKVMWKHAKG--SGNPQQYHPVPLTGRIQILPNSSLLIRH 816
D + ++ V KV + +G + Q+ P + + LLI
Sbjct: 2363 SDQKVCEGDIVQLEV------KVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIED 2416
Query: 817 VLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGER 876
+ +ED G Y + +S S ++V +IT + + I+G L C
Sbjct: 2417 MTKEDAGNY---SFTIPALGLSTSGRVSVYSVDVITPLKDVNV-IEGTKAVLECKVSVPD 2472
Query: 877 PIIIRWEKGDTVIDP-DRVMRYAIATK 902
++W D I P DRV TK
Sbjct: 2473 VTSVKWYLNDEQIKPDDRVQAIVKGTK 2499
Score = 47.4 bits (111), Expect = 2e-04
Identities = 26/90 (28%), Positives = 40/90 (44%), Gaps = 4/90 (4%)
Query: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPA----DSRWTKRITGLTI 341
PT++ G + V G +V L C SGYP P + W ++ + + + I L I
Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMI 1002
Query: 342 SDLRTEDSGTYICEVTNTFGSAEATGILMV 371
+ EDSG + C N G+ + L V
Sbjct: 1003 REAFAEDSGRFTCSAVNEAGTVSTSCYLAV 1032
Score = 47.0 bits (110), Expect = 2e-04
Identities = 57/223 (25%), Positives = 97/223 (43%), Gaps = 26/223 (11%)
Query: 199 GNVAVFKCLIPSSVQEYVSVVSWEKDTVSI--IPEHRFFITYHGG-LYISDVQKEDALST 255
G+ A+F+CL+ S ++ +W KD +I P+HRF L+I DVQ DA
Sbjct: 11133 GSSAIFECLVSPST----AITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDA-GE 11187
Query: 256 YRCITKHKYSGETRQSNGARLSVTD-PAESIPTILDGFHSQEVWAGHTVELPCTASGYPI 314
Y C+ + G +++ A+L V + P + T+ + V G + L C +
Sbjct: 11188 YTCVLR---LGNKEKTSTAKLVVEELPVRFVKTLEE---EVTVVKGQPLYLSCELNKER- 11240
Query: 315 PAIRWLKDGR-PLPADSRWTKRITGL----TISDLRTEDSGTYICEVTNTFGSAEATGIL 369
+ W KDG+ + R + GL TI+D D+GTY V N + E + +
Sbjct: 11241 -DVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENA-NNLECSSCV 11298
Query: 370 MVIDPLHVTLTP--KKLKTGIGSTVILSCALTGSPEFTIRWYR 410
V++ + L + T I +C + I+W++
Sbjct: 11299 KVVEVIRDWLVKPIRDQHVKPKGTAIFACDIAKDTP-NIKWFK 11340
Score = 46.6 bits (109), Expect = 3e-04
Identities = 109/571 (19%), Positives = 205/571 (35%), Gaps = 51/571 (8%)
Query: 281 PAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSR----WTK-R 335
P+ P I + SQ V G G P P W K+G + R W +
Sbjct: 2073 PSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDN 2132
Query: 336 ITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIG---STV 392
+ L I D+ EDS + + + N G + L+V +T T ++L+ + T+
Sbjct: 2133 VCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFT-QELQDVVAKEKDTM 2191
Query: 393 ILSCALTGSPEFTIRWYRN-TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRK 451
T P ++WY++ E+ D+ L I + S + Y C +
Sbjct: 2192 ATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLV-E 2250
Query: 452 AQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTV--TWALDDEPIV 509
+ + A + +E V + V L C P + W +D +
Sbjct: 2251 DENVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVS---PENIEGKWYHNDVELK 2307
Query: 510 RDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPP--S 567
+G +YT++ ++ V D G Y ++ + ++ ++ P
Sbjct: 2308 SNG-----KYTITSRRGRQNLTVKDVTKEDQGEYSF----VIDGKKTTCKLKMKPRPIAI 2358
Query: 568 IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDAL-LLPDNHRQVVFENGT--LKLTDV 624
++ + + G + +V + W KD + P + +V + + L + D+
Sbjct: 2359 LQGLSDQKVCEGDIVQLEVKVSLESVEGV-WMKDGQEVQPSDRVHIVIDKQSHMLLIEDM 2417
Query: 625 QKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDM 684
K D G Y ++ P L +S S V+V +I P + G + C VS D+
Sbjct: 2418 TK-EDAGNYSFTI---PALGLSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDV 2473
Query: 685 PIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAA--ATVSRER 742
+ W + + I V K L I+ G Y I +S E+
Sbjct: 2474 -TSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEK 2532
Query: 743 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
I+R R + Q+ ++ + + + +D V+W P + + G
Sbjct: 2533 IKIIR-GLRDLTCTETQNVVF-EVELSHSGID------VLWNFKDKEIKPSSKYKIEAHG 2584
Query: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGV 833
+I L + +++++D G Y A +
Sbjct: 2585 KIY-----KLTVLNMMKDDEGKYTFYAGENM 2610
Score = 46.2 bits (108), Expect = 3e-04
Identities = 34/114 (29%), Positives = 55/114 (48%), Gaps = 7/114 (6%)
Query: 267 ETRQSNGARLSVTDPAESI---PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDG 323
E +S+ +L V A I P++ FH+ V A +++ G P + W KDG
Sbjct: 25373 EKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDG 25432
Query: 324 RPLPADSRW----TKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVID 373
+ L +R +K +T L+I + ED GTY V+N+ GS ++V+D
Sbjct: 25433 QTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLD 25486
Score = 46.2 bits (108), Expect = 3e-04
Identities = 61/279 (21%), Positives = 115/279 (41%), Gaps = 29/279 (10%)
Query: 103 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDND-Y 161
V+ C +G PS + W+ + + +V + + +Y S N+ + D+ Y
Sbjct: 33151 VLFTCEISGEPSPEIEWF----KNNLPISISSNVSISRSRNVY--SLEIRNASVSDSGKY 33204
Query: 162 FCTAENAAGKIRSP-NIRVKAVFREP---YTVRVEDQRSMRGNVAVFKCLIPSSVQEYVS 217
A+N G+ + ++ V + EP +R S++G+ + + +S QE S
Sbjct: 33205 TIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQE-AS 33263
Query: 218 VVSWEKDTVSIIPEHRFFITYHGGLYISDVQK---EDALSTYRCITKHKYSGETRQSNGA 274
S+ + S + E +F +S +Q+ E + S++ I S T+ +
Sbjct: 33264 FSSFSSSSASSMTEMKF--ASMSAQSMSSMQESFVEMSSSSFMGI-----SNMTQLESST 33316
Query: 275 RLSVTDPAESIPTILDGFHSQ-EVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRW- 332
+ IP ++ S + G + + C +G P P + W GR + + +
Sbjct: 33317 SKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGR 33376
Query: 333 -----TKRITGLTISDLRTEDSGTYICEVTNTFGSAEAT 366
T +T L I D++ +D G Y + N FGS AT
Sbjct: 33377 FHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSAT 33415
Score = 45.8 bits (107), Expect = 4e-04
Identities = 50/161 (31%), Positives = 65/161 (40%), Gaps = 23/161 (14%)
Query: 1323 LWVAAVTSAGRGNSSEKVT------------IEPAGKAPAKIISFGGTVTTPWMKDVRLP 1370
L + AVT A G S K T + A AP + ++T VRL
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ 124
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNG---TLLLRAVKAEDSGYYTCTATN 1427
G P P VK+ +D + I S+D I G +LL+ EDSG Y+ ATN
Sbjct: 125 VRVTGIPTPVVKFYRDGAE--IQSSLDFQ--ISQEGDLYSLLIAEAYPEDSGTYSVNATN 180
Query: 1428 TGGFDTIIVNLLVQ----VPPDQPRLTVSKTSASSITLTWI 1464
+ G T LLVQ VP + + VS S T I
Sbjct: 181 SVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRI 221
Score = 45.8 bits (107), Expect = 4e-04
Identities = 32/102 (31%), Positives = 46/102 (45%), Gaps = 12/102 (11%)
Query: 749 PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILP 808
PP V N I G++ L C + GYP P V W ++ + + + QI
Sbjct: 942 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWY--------REDYQIESSIDFQITF 993
Query: 809 NSS---LLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI 847
S L+IR ED G + C A N GT +S S +L V++
Sbjct: 994 QSGIARLMIREAFAEDSGRFTCSAVNEAGT-VSTSCYLAVQV 1034
Score = 45.1 bits (105), Expect = 8e-04
Identities = 55/239 (23%), Positives = 96/239 (40%), Gaps = 23/239 (9%)
Query: 598 WYKDALLLPDNHRQVVFENGT---LKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVK 654
W KD + ++ + +G L + DVQ D GEY C + + + S + V +
Sbjct: 11151 WMKDGSNIRESPKHRFIADGKDRKLHIIDVQLS-DAGEYTCVLRLGNKEKTSTAKLVVEE 11209
Query: 655 VPP-LIQPFEFPPASI-GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESK-EFM 711
+P ++ E + GQ LY+ C ++ + WRKDG++++ G + M
Sbjct: 11210 LPVRFVKTLEEEVTVVKGQPLYLSCELNKER---DVVWRKDGKIVVEKPGRIVPGVIGLM 11266
Query: 712 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC 771
+L I+ G YT NA +V V ++V+P + K +
Sbjct: 11267 RALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFA 11326
Query: 772 SVDGYPPPKVMWKHAKGSGNPQQYHPVPL--TGRIQILPNSS---LLIRHVLEEDIGYY 825
P + W KG Y +P + +IL + + L I++ + EDI Y
Sbjct: 11327 CDIAKDTPNIKW--FKG------YDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEY 11377
Score = 45.1 bits (105), Expect = 8e-04
Identities = 35/104 (33%), Positives = 50/104 (48%), Gaps = 8/104 (7%)
Query: 278 VTDPAESIPTILDGFHSQE----VWAGHTVELPCTASGYPIPAIRWLKDGRPL-PADS-- 330
VT AE++P +D + + V AG V L T G P+P + W KDG L PA+
Sbjct: 19284 VTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIK 19343
Query: 331 -RWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVID 373
+ + L + + +DSG Y N+ GS AT L V+D
Sbjct: 19344 MAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLD 19387
Score = 45.1 bits (105), Expect = 8e-04
Identities = 121/595 (20%), Positives = 211/595 (35%), Gaps = 69/595 (11%)
Query: 78 PEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVH 137
PE + + V LQ T SS A G P W T D + +
Sbjct: 32845 PEPISSKPVIVT-GLQDTTVSSDSVAKFAVKATGEPRPTAIW---TKDG-------KAIT 32893
Query: 138 ANGTLQLYPFSPSAFNSFIHDND------YFCTAENAAGKIRSP-NIRVKAVFREPYTVR 190
G +L F IH D Y CT +N+AG + S + +KA+ ++ +
Sbjct: 32894 QGGKYKLSE-DKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAI-KDTEAQK 32951
Query: 191 VEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIP---EHRFFITYHGG--LYIS 245
V Q++ + K + VQE +S + + + + + + + L
Sbjct: 32952 VSTQKT--SEITPQKKAV---VQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISE 33006
Query: 246 DVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVEL 305
+V+K A S + I + + ++ S R A S ++ G + L
Sbjct: 33007 EVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSIN--------EGQRLVL 33058
Query: 306 PCTASGYPIPAIRWLKDGRPLPADSRWTKRITG----LTISDLRTEDSGTYICEVTNTFG 361
+G ++W+ +G L + ++G LTI D G C G
Sbjct: 33059 KANIAG--ATDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEG 33116
Query: 362 SAEATGILMVIDPLH----VTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLP 417
+ L + L P+ G V+ +C ++G P I W++N +
Sbjct: 33117 IVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISI 33176
Query: 418 DEAISI-RGLSNETLLITSAQKSHSGAY----QCFATRKAQTAQDFAIIALEDGTPRIVS 472
+SI R + +L I +A S SG Y + F + + TA + +E+ + +V
Sbjct: 33177 SSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVL 33236
Query: 473 SFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNV 532
S G FS A +++ S ++ ++S M
Sbjct: 33237 RTSGDTSLQG-SFSSQSVQMSASKQEASFSSFSSSSA--SSMTEMKFASMSAQSMSSMQE 33293
Query: 533 TGPQIRDG---GVYRCTARNLVGSAEYQARINVRG-PPSIRAM-RNITAVAGRDTLINCR 587
+ ++ G+ T L S + +RG PP I A+ +I+ G+ + C
Sbjct: 33294 SFVEMSSSSFMGISNMT--QLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACA 33351
Query: 588 VIGYPYYSIKWYKDALLLPDN-----HRQVVFENGTLKLTDVQKGMDEGEYLCSV 637
G P + W + H + + TL + DVQK D G Y S+
Sbjct: 33352 FTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQK-QDGGLYTLSL 33405
Score = 44.7 bits (104), Expect = 0.001
Identities = 60/238 (25%), Positives = 97/238 (40%), Gaps = 33/238 (13%)
Query: 1325 VAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSV--------GD 1376
++ + + + VT + KAP I S VT ++D + +SV G+
Sbjct: 32821 ISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTG--LQDTTVSSDSVAKFAVKATGE 32878
Query: 1377 PAPAVKWTKDSEDSAIPVSMDG-HRLIHTNGTLLLRAVKAE--DSGYYTCTATNTGGFDT 1433
P P WTKD + ++ G ++L G L K + DSG YTCT N+ G +
Sbjct: 32879 PRPTAIWTKDGK----AITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVS 32934
Query: 1434 IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFI 1493
L ++ D VS S IT + ++ + Q ++ SEE K
Sbjct: 32935 SSCKLTIKAIKDTEAQKVSTQKTSEIT------PQKKAVVQEEISQKAL-RSEEIKMSEA 32987
Query: 1494 SSSER-SFKLDSLKCGTWYKVKLAAKNSVGSGRISEII--------EAKTHGREPSFS 1542
S E+ + K ++ K +VK +A S+ + E I E +TH +FS
Sbjct: 32988 KSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFS 33045
Score = 44.3 bits (103), Expect = 0.001
Identities = 101/486 (20%), Positives = 169/486 (34%), Gaps = 111/486 (22%)
Query: 336 ITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGI------- 388
ITG T+ + R E +VT T V P+ + +TP L +G+
Sbjct: 906 ITGTTVREERFEVLHGREAKVTET---------ARVPAPVEIPVTPPTLVSGLKNVTVIE 956
Query: 389 GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSN-ETLLITSAQKSHSGAYQCF 447
G +V L C ++G P T+ WYR + I S L+I A SG + C
Sbjct: 957 GESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCS 1016
Query: 448 ATRKAQTAQDFAIIAL------EDGTPRIVSSF--------------------SEKVVNP 481
A +A T +A+ E T + F +E+ P
Sbjct: 1017 AVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGP 1076
Query: 482 GEQFS-------------------LMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMS 522
GE + C G P P V W P+ ++ + Y
Sbjct: 1077 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVS-YNKQ 1135
Query: 523 DGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQA--------RINVRGPPSIRAMRNI 574
G +++T D G Y RN G A + ++ + +
Sbjct: 1136 TGECKLVISMTFAD--DAGEYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQV 1193
Query: 575 TAVAGRDTLINCRVIGYPY--YSIKWYKD-ALLLPDNHRQVV---------------FEN 616
TA ++ + G+ Y Y ++ K+ AL+ + V FE
Sbjct: 1194 TAFV-QEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEE 1252
Query: 617 GTLK-------LTDVQKGMDE-GEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPAS 668
+K T +++ ++E GE +V I ++ +K +++
Sbjct: 1253 RLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKNYRILE-------- 1304
Query: 669 IGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIE-SKEFMSSLQISSVSLKHNGNY 727
G + C +S +P +I W KDG+ I G ++ ++ +SL+I V + G Y
Sbjct: 1305 -GMGVTFHCKMSGYPLP-KIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIY 1362
Query: 728 TCIASN 733
T ASN
Sbjct: 1363 TAFASN 1368
Score = 44.3 bits (103), Expect = 0.001
Identities = 55/208 (26%), Positives = 86/208 (41%), Gaps = 24/208 (11%)
Query: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTN--GTLLLRAVKAEDSGYYT 1422
K V L C D V W+KD + +P D +++ + TL + K +DSG Y
Sbjct: 3659 KKVHLECQVDEDRKVTVTWSKDGQ--KLPPGKD-YKICFEDKIATLEIPLAKLKDSGTYV 3715
Query: 1423 CTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNG--GSSIRGF-VLQ 1479
CTA+N G + + V+ PP V K S + L PG++ ++G V+Q
Sbjct: 3716 CTASNEAGSSSCSATVTVREPPS----FVKKVDPSYLML---PGESARLHCKLKGSPVIQ 3768
Query: 1480 YS-VDNSEEWKD-----VFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAK 1533
+ N++E + ++ +SE + +K A N VGS S I K
Sbjct: 3769 VTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIK 3828
Query: 1534 THGREPSFSKDQHLFTHINSTHARLNLQ 1561
PSF K + T+A L +
Sbjct: 3829 ---EPPSFIKTLEPADIVRGTNALLQCE 3853
Score = 43.9 bits (102), Expect = 0.002
Identities = 54/201 (26%), Positives = 83/201 (41%), Gaps = 46/201 (22%)
Query: 211 SVQEYVSVVSWEKDTVSII---PEHRFFITYHGGL----YISDVQKEDALSTYRCI---- 259
S E + V S KD+VS+ PEH GG Y+ + ++ + +C
Sbjct: 26376 SPPEKLGVTSISKDSVSLTWLKPEH------DGGSRIVHYVVEALEKGQKNWVKCAVAKS 26429
Query: 260 TKHKYSGETRQS---------NGARLSVTDPAESIPTIL------------DGFHSQEVW 298
T H SG S N A LS DP E + +L F S V+
Sbjct: 26430 THHVVSGLRENSEYFFRVFAENQAGLS--DPRELLLPVLIKEQLEPPEIDMKNFPSHTVY 26487
Query: 299 --AGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG----LTISDLRTEDSGTY 352
AG +++ SG P+P + +DG PL A R+ IT + + + T D+G Y
Sbjct: 26488 VRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRY 26547
Query: 353 ICEVTNTFGSAEATGILMVID 373
N+ G+ +A ++V+D
Sbjct: 26548 EITAANSSGTTKAFINIVVLD 26568
Score = 43.9 bits (102), Expect = 0.002
Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 4/100 (4%)
Query: 299 AGHTVELPCTASGYPIPAIRWLKDGRPLPADS----RWTKRITGLTISDLRTEDSGTYIC 354
AG +V+L SG P P I W KD + L ++ T + + I D +SG Y
Sbjct: 26886 AGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYEL 26945
Query: 355 EVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVIL 394
++ N GSA AT + ++D P + KT + L
Sbjct: 26946 KLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITL 26985
Score = 43.1 bits (100), Expect = 0.003
Identities = 57/272 (20%), Positives = 90/272 (33%), Gaps = 60/272 (22%)
Query: 304 ELPCTASGYPIPAIRWLKDGRPLPADSRWTK----RITGLTISDLRTEDSGTYICEVTNT 359
E T G P + WL DG+PL A +R L + DSG C TN
Sbjct: 1723 ECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNK 1782
Query: 360 FGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDE 419
+G+ + L+V D E L +E
Sbjct: 1783 YGTDHTSATLIVKD---------------------------------------EKSLVEE 1803
Query: 420 AISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVV 479
+ G + + +H GA T + + + P IV V
Sbjct: 1804 SQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQK-----------PDIVLYPEPVRV 1852
Query: 480 NPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRD 539
GE C G P P V W L+ + I + R DG I ++++ + D
Sbjct: 1853 LEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY----DG--IHYLDIVDCKSYD 1906
Query: 540 GGVYRCTARNLVGSAEYQARINVRGPPSIRAM 571
G + TA N G E++ ++ ++ R++
Sbjct: 1907 TGEVKVTAENPEGVIEHKVKLEIQQREDFRSV 1938
Score = 43.1 bits (100), Expect = 0.003
Identities = 45/160 (28%), Positives = 64/160 (40%), Gaps = 16/160 (10%)
Query: 221 WEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGA-RLSVT 279
W K S I E+ F ++ GL EDA +R I K+ + S + ++
Sbjct: 21403 WLKANFSNILENEFTVS---GL------TEDAAYEFRVIAKNAAGAISPPSEPSDAITCR 21453
Query: 280 DPAESIPTILDGFHSQEVW--AGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI- 336
D E+ +D V AG L SG P P + W KDG+ L ++ +I
Sbjct: 21454 DDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIA 21513
Query: 337 ---TGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVID 373
T L D DSG Y TN G A+ + V+D
Sbjct: 21514 DFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLD 21553
Score = 42.7 bits (99), Expect = 0.004
Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
Query: 297 VWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRW----TKRITGLTISDLRTEDSGTY 352
V AG + ++ G PIP I+W+K + L +R T T L++ D DSG Y
Sbjct: 22555 VHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNY 22614
Query: 353 ICEVTNTFGSAEATGILMVID 373
I + N G T + V+D
Sbjct: 22615 ILKAKNVAGERSVTVNVKVLD 22635
Score = 42.4 bits (98), Expect = 0.005
Identities = 107/557 (19%), Positives = 194/557 (34%), Gaps = 68/557 (12%)
Query: 191 VEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG---LYISDV 247
+ DQ+ G++ + + E V W KD + P R I L I D+
Sbjct: 2362 LSDQKVCEGDIVQLEVKVSLESVEGV----WMKDGQEVQPSDRVHIVIDKQSHMLLIEDM 2417
Query: 248 QKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPC 307
KEDA + I S R S + + V P + + I G L C
Sbjct: 2418 TKEDAGNYSFTIPALGLSTSGRVSVYS-VDVITPLKDVNVI----------EGTKAVLEC 2466
Query: 308 TASGYPIPAIRWLKDGRPLPADSRWTKRITG----LTISDLRTEDSGTYICEV----TNT 359
S + +++W + + D R + G L I+ D G Y V TN
Sbjct: 2467 KVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNC 2526
Query: 360 FGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDE 419
S E I+ + L T T V+ L+ S + W + + P
Sbjct: 2527 NLSVEKIKIIRGLRDLTCTET---------QNVVFEVELSHSG-IDVLWNFKDKEIKPSS 2576
Query: 420 AISIRGLSN-ETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKV 478
I L + + K G Y +A + + + + G I +++
Sbjct: 2577 KYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGK----LTVAGGA--ISKPLTDQT 2630
Query: 479 VNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH---RTNQYTMSDGTTISHMNVTGP 535
V ++ C P W +RDG H N + SDG + +
Sbjct: 2631 VAESQEAVFECEVAN-PDSKGEW-------LRDGKHLPLTNNIRSESDGHK-RRLIIAAT 2681
Query: 536 QIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYS 595
++ D G Y V +++ A++ V + ++N+T +D + +
Sbjct: 2682 KLDDIGEYTYK----VATSKTSAKLKVEAVKIKKTLKNLTVTETQDAVFTVELTHPNVKG 2737
Query: 596 IKWYKDALLLPDNHRQVVFENGTLKLTDVQKG--MDEGEYLCSVLIQPQLSISQSVHVAV 653
++W K+ ++L N + + GT+ ++ +DE Y + +L S +H V
Sbjct: 2738 VQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRL---GRLGASARLH--V 2792
Query: 654 KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS 713
+ +I+ + A + VS +P++ W I + S+ +
Sbjct: 2793 ETVKIIKKPKDVTALENATVAFEVSVSHDTVPVK--WFHKSVEIKPSDKHRLVSERKVHK 2850
Query: 714 LQISSVSLKHNGNYTCI 730
L + ++S G YT +
Sbjct: 2851 LMLQNISPSDAGEYTAV 2867
Score = 42.4 bits (98), Expect = 0.005
Identities = 38/122 (31%), Positives = 51/122 (41%), Gaps = 11/122 (9%)
Query: 1331 AGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDS 1390
AGR SS VT+ P +++ VT K R G P P + W K+ +
Sbjct: 3222 AGRNRSS--VTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLL 3279
Query: 1391 AIPVSMDGHRLIHTNG--TLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP----P 1444
+ + +H TLLL ED+ YTC A N G T +L V+VP P
Sbjct: 3280 STGFKC---KFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSP 3336
Query: 1445 DQ 1446
DQ
Sbjct: 3337 DQ 3338
Score = 42.4 bits (98), Expect = 0.005
Identities = 41/145 (28%), Positives = 62/145 (42%), Gaps = 17/145 (11%)
Query: 250 EDALSTYRCITKHKYSG--ETRQSNGARLSVTDPAESIPTILDGFHSQE--VWAGHTVEL 305
ED +R I ++ E S+GA ++ D ++ LD + V AG T L
Sbjct: 24669 EDQRYEFRVIARNAAGNFSEPSDSSGA-ITARDEIDAPNASLDPKYKDVIVVHAGETFVL 24727
Query: 306 PCTASGYPIPAIRWLKDGRPLP-----ADSRWTKRITGLTISDLRTEDSGTYICEVTNTF 360
G PIP + W KDG+ L + + T + T L + D D G YI +++N
Sbjct: 24728 EADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVG 24787
Query: 361 GSAEATGILMVID-------PLHVT 378
G+ + V+D PL VT
Sbjct: 24788 GTKSIPITVKVLDRPGPPEGPLKVT 24812
Score = 42.0 bits (97), Expect = 0.006
Identities = 24/81 (29%), Positives = 37/81 (45%), Gaps = 3/81 (3%)
Query: 296 EVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI---TGLTISDLRTEDSGTY 352
++ AG T+ +P +G P+P W K+ L D + + L I D +D G Y
Sbjct: 15115 QIMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRY 15174
Query: 353 ICEVTNTFGSAEATGILMVID 373
+ TN+ GS A + V D
Sbjct: 15175 VITATNSCGSKFAAARVEVFD 15195
Score = 41.6 bits (96), Expect = 0.008
Identities = 46/197 (23%), Positives = 71/197 (36%), Gaps = 10/197 (5%)
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
C+ G + W KD+ + P L+ TL + V D+G YTC A+N G
Sbjct: 7233 CHVTGTAPIKITWAKDNREIR-PGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAG 7291
Query: 1431 FDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGS---SIRGFVLQYSVDNSEE 1487
D+ L VQ PP + T GGS + + + + S +
Sbjct: 7292 KDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSK 7351
Query: 1488 WKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHL 1547
++ F+ S ++ +L A N+ GS S ++ K P F K H
Sbjct: 7352 FRMSFV-DSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVK---EPPIFRKKPHP 7407
Query: 1548 FTHIN--STHARLNLQG 1562
+ H LQG
Sbjct: 7408 IETLKGADVHLECELQG 7424
Score = 41.6 bits (96), Expect = 0.008
Identities = 31/97 (31%), Positives = 46/97 (47%), Gaps = 16/97 (16%)
Query: 479 VNPGEQFSLMCAAKGAPPPTVTWAL-------DDEPIVRDGSHRTNQYTMSDGTTISHMN 531
V G +++ KG P PT+TW + EP++ D N+ + D T+
Sbjct: 16128 VEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDT--HVNKLVVDDTCTL---- 16181
Query: 532 VTGPQIR--DGGVYRCTARNLVGSAEYQARINVRGPP 566
PQ R D G+Y TA N +G+A + R+NV G P
Sbjct: 16182 -VIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRP 16217
Score = 41.6 bits (96), Expect = 0.008
Identities = 31/106 (29%), Positives = 45/106 (42%), Gaps = 4/106 (3%)
Query: 479 VNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIR 538
V G+ L +G P P V W D + S R T +D + S +T +
Sbjct: 18213 VKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFS---LTKAKRS 18269
Query: 539 DGGVYRCTARNLVGSAEYQARINVRGPPS-IRAMRNITAVAGRDTL 583
DGG Y TA N GS A +NV P +R ++ + + R T+
Sbjct: 18270 DGGKYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTV 18315
Score = 41.2 bits (95), Expect = 0.011
Identities = 34/126 (26%), Positives = 55/126 (43%), Gaps = 4/126 (3%)
Query: 1325 VAAVTSAGRGNSSEKVTIEPAG-KAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKW 1383
V A AGR + S +T+E + + V + + + G+P P + W
Sbjct: 1530 VVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVW 1589
Query: 1384 TKDSEDSAIPVSMDGHRLIHTNGTLLLR--AVKAEDSGYYTCTATNTGGFDTIIVNLLVQ 1441
K+S D +P R+ T G L+ + ++DS +YT TA N G DT + V+
Sbjct: 1590 LKNS-DIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVE 1648
Query: 1442 VPPDQP 1447
V +P
Sbjct: 1649 VEFAEP 1654
Score = 41.2 bits (95), Expect = 0.011
Identities = 72/305 (23%), Positives = 121/305 (39%), Gaps = 38/305 (12%)
Query: 1250 VPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLF 1309
V G PA ++A A + V WL + VIR+ S + E F
Sbjct: 5622 VAGEPAELQASIEGAQPIFVQWL--KEKEEVIRE---------SENIRITFVENVATLQF 5670
Query: 1310 YRIAHLNRGQQYLLWVAAVTSAG--RGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDV 1367
+ N G+ ++ + + G R N + + +E PA I+ G +T +
Sbjct: 5671 AKAEPANAGK----YICQIKNDGGMRENMATLMVLE-----PAVIVEKAGPMTVTVGETC 5721
Query: 1368 RLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTN--GTLLLRAVKAEDSGYYTCTA 1425
L C G P +V+W KD + + S H+ N +L + +V+ +D+G YT
Sbjct: 5722 TLECKVAGTPELSVEWYKDGK---LLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQV 5778
Query: 1426 TNTGGFD--TIIVNLLVQ-VPPDQPRL---TVSKTSASSITLTWIPGDNGGSSIRGFVLQ 1479
N G T +V++ + VPP R T AS I + G + S+ F +
Sbjct: 5779 QNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAG-SSPISVAWFHEK 5837
Query: 1480 YSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREP 1539
+ + +++ F S + + +L+SL A N GS ++ T P
Sbjct: 5838 TKIVSGAKYQTTF-SDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVL---TVQEPP 5893
Query: 1540 SFSKD 1544
SF K+
Sbjct: 5894 SFVKE 5898
Score = 40.8 bits (94), Expect = 0.014
Identities = 24/81 (29%), Positives = 37/81 (45%), Gaps = 4/81 (4%)
Query: 297 VWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRW----TKRITGLTISDLRTEDSGTY 352
V AG +++ +G P+P I W KDG + +R T T LT+ D D+G Y
Sbjct: 25801 VKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQY 25860
Query: 353 ICEVTNTFGSAEATGILMVID 373
+ + N G+ V+D
Sbjct: 25861 VLTLKNVAGTRSVAVNCKVLD 25881
Score = 40.8 bits (94), Expect = 0.014
Identities = 25/79 (31%), Positives = 36/79 (45%), Gaps = 4/79 (5%)
Query: 299 AGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWT----KRITGLTISDLRTEDSGTYIC 354
AG VEL +G P PA W G L R T ++ LTI + D+G Y
Sbjct: 29752 AGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTL 29811
Query: 355 EVTNTFGSAEATGILMVID 373
E+ N G+ T ++++D
Sbjct: 29812 ELKNVTGTTSETIKVIILD 29830
Score = 40.8 bits (94), Expect = 0.014
Identities = 24/70 (34%), Positives = 37/70 (52%), Gaps = 6/70 (8%)
Query: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTN---GTLLLRAVKAEDSGYYTCTATNTGGF 1431
G P P +KW KD + ++ +++ +IH L +R ED+GYY TATNT G
Sbjct: 31820 GIPPPTLKWEKDGQPLSLGPNIE---IIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGS 31876
Query: 1432 DTIIVNLLVQ 1441
+ +L V+
Sbjct: 31877 TSCQAHLQVE 31886
Score = 40.0 bits (92), Expect = 0.024
Identities = 33/138 (23%), Positives = 57/138 (41%), Gaps = 7/138 (5%)
Query: 468 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTI 527
P VV G + G P P V+W D + ++ + Q + SDG
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQ-VISTSTLPGVQISFSDGR-- 62
Query: 528 SHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG---PPS-IRAMRNITAVAGRDTL 583
+ + + + G Y A N G A A + V+ PP+ ++ ++++T G
Sbjct: 63 AKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVR 122
Query: 584 INCRVIGYPYYSIKWYKD 601
+ RV G P +K+Y+D
Sbjct: 123 LQVRVTGIPTPVVKFYRD 140
Score = 40.0 bits (92), Expect = 0.024
Identities = 89/434 (20%), Positives = 145/434 (33%), Gaps = 85/434 (19%)
Query: 297 VWAGHTVELPCTASGYPIPAIRWLK--DGRPLPADSRWTKRITGLTISDLRTEDSGTYIC 354
V AG ++ L G P P W K L AD T + LT+ + D+G Y
Sbjct: 28369 VRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTL 28428
Query: 355 EVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTEL 414
V N GS T + V+D TP G + GS T+ W
Sbjct: 28429 TVENNSGSKSITFTVKVLD------TP-----GPPGPITFKDVTRGSA--TLMW------ 28469
Query: 415 VLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSF 474
+A + G + + +++ ++Q + + T Q F + L +G P
Sbjct: 28470 ----DAPLLDGGARIHHYVVEKREASRRSWQVISEK--CTRQIFKVNDLAEGVPYYFRVS 28523
Query: 475 SEKVVNPGEQFS----LMCAAKGAPP------------PTVTWALDDEPIVRDGSHRTNQ 518
+ GE + ++ + APP + W D DG R
Sbjct: 28524 AVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPD----HDGGSRITG 28579
Query: 519 YTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG-------------- 564
Y + S V + T LV EY+ R+ +
Sbjct: 28580 YLLEMRQKGSDFWVEAGHTKQ---LTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSV 28636
Query: 565 ---PPSIRAMRNITAV--------AGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVV 613
P I ++T + AG I+ + G P + W + + L + R +
Sbjct: 28637 IIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSI 28696
Query: 614 F---ENGTLKLTDVQKGMDEGEYLCSVLIQPQL-SISQSVHVAVKVPPLIQPFEFPPASI 669
+ TL + D +G D G Y ++ + + S +V V + P+ P E S
Sbjct: 28697 TTTKDRTTLTVKDSMRG-DSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVSSVSA 28755
Query: 670 GQLLYIPCVVSSGD 683
CV+S G+
Sbjct: 28756 ES-----CVLSWGE 28764
Score = 39.7 bits (91), Expect = 0.032
Identities = 27/91 (29%), Positives = 39/91 (42%), Gaps = 4/91 (4%)
Query: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKR----ITGLTI 341
PTI H V G + +P P+P + W KDG+ + A R T + L +
Sbjct: 14387 PTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEV 14446
Query: 342 SDLRTEDSGTYICEVTNTFGSAEATGILMVI 372
D+G Y + N GSA A+ + VI
Sbjct: 14447 PKSVRADAGIYTITLENKLGSATASINVKVI 14477
Score = 39.7 bits (91), Expect = 0.032
Identities = 27/92 (29%), Positives = 42/92 (45%), Gaps = 8/92 (8%)
Query: 478 VVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQI 537
++ GE F L G PPPT+ W+ D + + +G+ + T + + + T
Sbjct: 21472 ILKAGEAFRLEADVSGRPPPTMEWSKDGKEL--EGTAKLEIKIADFSTNLVNKDSTR--- 21526
Query: 538 RDGGVYRCTARNLVGSAEYQARINV---RGPP 566
RD G Y TA N G A++ + V GPP
Sbjct: 21527 RDSGAYTLTATNPGGFAKHIFNVKVLDRPGPP 21558
Score = 39.7 bits (91), Expect = 0.032
Identities = 22/74 (29%), Positives = 37/74 (50%), Gaps = 4/74 (5%)
Query: 299 AGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG----LTISDLRTEDSGTYIC 354
AG V++ G P P + W KD + L +D+R++ T LTI + D+G YI
Sbjct: 27285 AGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYIL 27344
Query: 355 EVTNTFGSAEATGI 368
+ N G +++ +
Sbjct: 27345 TIENGVGEPKSSTV 27358
Score = 39.7 bits (91), Expect = 0.032
Identities = 25/93 (26%), Positives = 41/93 (44%), Gaps = 12/93 (12%)
Query: 283 ESIPTILDG----FHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI-- 336
E++P I++ F + +G ++ + G P+P + W KDG + + R I
Sbjct: 27952 ENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDG--VEIEKRMNMEITD 28009
Query: 337 ----TGLTISDLRTEDSGTYICEVTNTFGSAEA 365
T L + D + G Y E N GSA+A
Sbjct: 28010 VLGSTSLFVRDATRDHRGVYTVEAKNASGSAKA 28042
Score = 39.7 bits (91), Expect = 0.032
Identities = 79/375 (21%), Positives = 130/375 (34%), Gaps = 65/375 (17%)
Query: 299 AGHTVELPCTASGYPIPAIRWLKDGRPLPADS--RWTKRITGLTISDLRTEDSGTYICEV 356
AG ++ L + SG P P I W K G L + + T+ + L + + D+G Y E
Sbjct: 29460 AGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEA 29519
Query: 357 TNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVL 416
N G AT ++ V D TP G + TI W
Sbjct: 29520 ENQSGKKSATVLVKVYD------TP-------GPCPSVKVKEVSRDSVTITW-------- 29558
Query: 417 PDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSE 476
E +I G + I +++ A++ T+ ++T + I L +GT E
Sbjct: 29559 --EIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTL--YRISGLVEGTMYYFRVLPE 29614
Query: 477 KVVNPGEQFSLMCAAKGAPPPTV------------TWALDDEPIVRDGSHRTNQYTM--- 521
+ GE A + P V T L E + DG R Y +
Sbjct: 29615 NIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEAC 29674
Query: 522 SDGT-----------TISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRA 570
GT T+ VT + ++R A+N G +E + + +R
Sbjct: 29675 KAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRV 29734
Query: 571 M----------RNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLK 620
+ + I AGR + + G P + W+ L ++ R V + +
Sbjct: 29735 LPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVA 29794
Query: 621 LTDVQKG--MDEGEY 633
+++ D GEY
Sbjct: 29795 KLTIRETTIRDTGEY 29809
Score = 39.7 bits (91), Expect = 0.032
Identities = 39/168 (23%), Positives = 56/168 (33%), Gaps = 13/168 (7%)
Query: 444 YQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWAL 503
Y C T K + + LE P K GE P P VTW
Sbjct: 31667 YYCRRTMKKIKRRTDTMRLLER-PPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYK 31725
Query: 504 DDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV- 562
+ I + + +YT + + + D Y ARN G +A++ V
Sbjct: 31726 SGQKIKPGDNDK--KYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVT 31783
Query: 563 -RGPPSIRAMR--------NITAVAGRDTLINCRVIGYPYYSIKWYKD 601
PP+ +R N G+ RV G P ++KW KD
Sbjct: 31784 LHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKD 31831
Score = 39.7 bits (91), Expect = 0.032
Identities = 21/80 (26%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Query: 680 SSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVS 739
+ G+ +TW + GQV+ + + + + ++ S+ +ISSV GNY+ + N+
Sbjct: 32584 TDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQE 32643
Query: 740 RERQLIV---RVPPRFVVQP 756
E L + RV + V P
Sbjct: 32644 AEFTLTIQKARVTEKAVTSP 32663
Score = 39.7 bits (91), Expect = 0.032
Identities = 36/139 (25%), Positives = 62/139 (44%), Gaps = 21/139 (15%)
Query: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNG---TLLLRAVKAEDSGYY 1421
++V C G+P+P ++W K++ +P+S+ + I + +L +R DSG Y
Sbjct: 33149 QNVLFTCEISGEPSPEIEWFKNN----LPISISSNVSISRSRNVYSLEIRNASVSDSGKY 33204
Query: 1422 TCTATNTGGFDTIIVNLLVQVPPDQP-RLTVSKTSASSITLTWIPGDNGGSSIRGFVLQY 1480
T A N G + +L+V ++P R V +TS G +S++G
Sbjct: 33205 TIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTS-------------GDTSLQGSFSSQ 33251
Query: 1481 SVDNSEEWKDVFISSSERS 1499
SV S ++ SS S
Sbjct: 33252 SVQMSASKQEASFSSFSSS 33270
Score = 38.9 bits (89), Expect = 0.054
Identities = 41/168 (24%), Positives = 67/168 (39%), Gaps = 9/168 (5%)
Query: 1326 AAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTK 1385
+A G +SS ++T K+P I ++ + C+ G + W+K
Sbjct: 6248 SASNPLGTASSSARLTAREPKKSPFFDIK-PVSIDVIAGESADFECHVTGAQPMRITWSK 6306
Query: 1386 DSEDSAIPVSMDGHRLIHTNGT---LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQV 1442
D+++ + G+ I G L + V DSG YTC ATN G D L V+
Sbjct: 6307 DNKE----IRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKE 6362
Query: 1443 PPD-QPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWK 1489
PP +L SK + ++ +G I+ + + E WK
Sbjct: 6363 PPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWK 6410
Score = 38.9 bits (89), Expect = 0.054
Identities = 28/78 (35%), Positives = 33/78 (42%), Gaps = 6/78 (7%)
Query: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNG---TLLLRAVKAEDSGYYTCTATNTGGF 1431
GDP P VKWTK ++ G IH G L +R DSG Y C A N G
Sbjct: 8479 GDPIPNVKWTKGKWRQ---LNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGE 8535
Query: 1432 DTIIVNLLVQVPPDQPRL 1449
VNL V Q ++
Sbjct: 8536 IESNVNLQVDERKKQEKI 8553
Score = 38.9 bits (89), Expect = 0.054
Identities = 47/153 (30%), Positives = 65/153 (42%), Gaps = 21/153 (13%)
Query: 220 SWEKDTVSIIPEHRFFIT--YHGGLYISDVQKEDALSTYRCITKHKYSGET---RQSNGA 274
SW K +PE F +T GG Y ++ A +T I+ S ET + A
Sbjct: 20319 SWMKANHVNVPECAFTVTDLVEGGKYEFRIR---AKNTAGAISAPSESTETIICKDEYEA 20375
Query: 275 RLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTAS-GYPIPAIRWLKDGRPL-PADSRW 332
V DP TI DG + AG T+ L + G P+P W K G+ + P+D
Sbjct: 20376 PTIVLDP-----TIKDGL---TIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQ 20427
Query: 333 ---TKRITGLTISDLRTEDSGTYICEVTNTFGS 362
T + LTI +D+G Y TN FG+
Sbjct: 20428 ITSTPTSSMLTIKYATRKDAGEYTITATNPFGT 20460
Score = 38.5 bits (88), Expect = 0.070
Identities = 35/195 (17%), Positives = 76/195 (38%), Gaps = 8/195 (4%)
Query: 560 INVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHR---QVVFEN 616
+ + P + ++++ + G + G+P + W++D ++ + Q+ F +
Sbjct: 1 MTTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSD 60
Query: 617 GTLKLT-DVQKGMDEGEYLCSVLI---QPQLSISQSVHVAVKVPPLIQPFEFPPASIGQL 672
G KLT + G Y Q + V P +Q + G
Sbjct: 61 GRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQ 120
Query: 673 LYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIAS 732
+ + V+ P+ + + +DG I S I + + SL I+ + +G Y+ A+
Sbjct: 121 VRLQVRVTGIPTPV-VKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNAT 179
Query: 733 NAAATVSRERQLIVR 747
N+ + +L+V+
Sbjct: 180 NSVGRATSTAELLVQ 194
Score = 38.5 bits (88), Expect = 0.070
Identities = 51/212 (24%), Positives = 76/212 (35%), Gaps = 48/212 (22%)
Query: 1359 VTTPWMKDVRLPCNSV-------GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTN----GT 1407
VT P KDV LP ++V G ++W K +++ + G T +
Sbjct: 4209 VTKPGSKDV-LPGSAVCLKSTFQGSTPLTIRWFKGNKEL-----VSGGSCYITKEALESS 4262
Query: 1408 LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP---------------DQPRLTVS 1452
L L VK DSG YTC +N G NL V+ P D +L
Sbjct: 4263 LELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACK 4322
Query: 1453 KTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYK 1512
T I +TW D + S + + F+ S+ +L + +
Sbjct: 4323 VTGTPPIKITWFANDR------------EIKESSKHRMSFVEST-AVLRLTDVGIEDSGE 4369
Query: 1513 VKLAAKNSVGSGRISEIIEAKTHGREPSFSKD 1544
A+N GS S I+ K P F+K+
Sbjct: 4370 YMCEAQNEAGSDHCSSIVIVK---ESPYFTKE 4398
Score = 38.5 bits (88), Expect = 0.070
Identities = 46/226 (20%), Positives = 85/226 (37%), Gaps = 31/226 (13%)
Query: 274 ARLSVTDPAESIPTILDGFHSQE--VWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSR 331
AR + P P + D S W+ + +GY + + ++G+
Sbjct: 16415 ARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGY---IVEYKEEGK-----EE 16466
Query: 332 WTK------RITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPK--- 382
W K R T L ++ L+ + N G E + VI+ ++P
Sbjct: 16467 WEKGKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQL 16526
Query: 383 ------KLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSA 436
++ G + + ++G P T+ W N E LP EA + +++I +
Sbjct: 16527 DASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMN-ERTLPQEATIETTAISSSMVIKNC 16585
Query: 437 QKSHSGAYQCFATRKAQTAQDFAIIALED-----GTPRIVSSFSEK 477
Q+SH G Y A +A + I+ + D GTP + + + +
Sbjct: 16586 QRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNE 16631
Score = 38.5 bits (88), Expect = 0.070
Identities = 27/93 (29%), Positives = 36/93 (38%), Gaps = 8/93 (8%)
Query: 478 VVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQI 537
VV G +G P PT W D I D YT+ S + +
Sbjct: 17521 VVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD-----EHYTVETDNFSSVLTIKNCLR 17575
Query: 538 RDGGVYRCTARNLVGS---AEYQARINVRGPPS 567
RD G Y+ T N GS A + ++V GPP+
Sbjct: 17576 RDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPT 17608
Score = 38.5 bits (88), Expect = 0.070
Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 6/82 (7%)
Query: 297 VWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRW-----TKRITGLTISDLRTEDSGT 351
V G T+ + G P P I W K+G+ L + R R+ L I + D G
Sbjct: 17920 VRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVE-LQIKEAVRADHGK 17978
Query: 352 YICEVTNTFGSAEATGILMVID 373
YI N+ G A+ + I+ V+D
Sbjct: 17979 YIISAKNSSGHAQGSAIVNVLD 18000
Score = 38.5 bits (88), Expect = 0.070
Identities = 45/168 (26%), Positives = 66/168 (39%), Gaps = 17/168 (10%)
Query: 218 VVSWEKDTVSIIPE------HRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQS 271
+V W + II + F YH L I+ V +DA T + G S
Sbjct: 30958 IVKWYRQGKEIIADGLKYRIQEFKGGYHQ-LIIASVTDDDA--TVYQVRATNQGGSV--S 31012
Query: 272 NGARLSVTDPAE-SIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADS 330
A L V PA+ +P L+G + G V + SG P P I W K + +
Sbjct: 31013 GTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNG 31072
Query: 331 RW----TKRITGLTI-SDLRTEDSGTYICEVTNTFGSAEATGILMVID 373
+ T+ T L + + +D+G Y+ N FG + T L V D
Sbjct: 31073 HYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVAD 31120
Score = 38.5 bits (88), Expect = 0.070
Identities = 75/362 (20%), Positives = 124/362 (34%), Gaps = 58/362 (16%)
Query: 431 LLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCA 490
+++++A+ S GA + ++K + + ++E G + V G +C
Sbjct: 31536 MVVSAARISCGGAIR---SQKGVSVAKVKVASIEIGP--VSGQIMHAVGEEGGHVKYVCK 31590
Query: 491 AKGAPPPT-VTWALDDEPIVRDGSHRTNQYTMSDGTTISHM-NVTGPQIRDGGVYRCTAR 548
+ T VTW + + + T DG I ++ ++T D G YRC
Sbjct: 31591 IENYDQSTQVTWYFGVRQLENSEKY---EITYEDGVAILYVKDITK---LDDGTYRCKVV 31644
Query: 549 NLVGSAEYQARINVRG----------------------------PPSIR-AMRNITAVAG 579
N G A + V+G PP + N TA G
Sbjct: 31645 NDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVG 31704
Query: 580 RDTLINCRVIGYPYYSIKWYKDALLLP--DNHRQVVFEN--GTLKLTDVQKGMDEGEYLC 635
+ + +P + WYK + DN ++ FE+ G +LT D+
Sbjct: 31705 ENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYT 31764
Query: 636 SVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPC---------VVSSGDMPI 686
V S + V + P P L C + SG P
Sbjct: 31765 VVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPP 31824
Query: 687 RITWRKDGQVIISGSGVTI--ESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQL 744
+ W KDGQ + G + I E ++ +L I + G Y A+N A + S + L
Sbjct: 31825 TLKWEKDGQPLSLGPNIEIIHEGLDYY-ALHIRDTLPEDTGYYRVTATNTAGSTSCQAHL 31883
Query: 745 IV 746
V
Sbjct: 31884 QV 31885
Score = 37.4 bits (85), Expect = 0.16
Identities = 41/132 (31%), Positives = 55/132 (41%), Gaps = 20/132 (15%)
Query: 1375 GDPAPAVKWTKDSEDSAI-PVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDT 1433
G P +KW KD + P G L + L L +V A +G YTC TN G D+
Sbjct: 5355 GTPPFKIKWFKDDVELVSGPKCFIG--LEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDS 5412
Query: 1434 IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDN--------GGSSIR--GFVLQYSVD 1483
LLV PP V K AS I GD+ G IR F ++ +
Sbjct: 5413 CTTMLLVTEPPK----FVKKLEASKIVKA---GDSSRLECKIAGSPEIRVVWFRNEHELP 5465
Query: 1484 NSEEWKDVFISS 1495
S++++ FI S
Sbjct: 5466 ASDKYRMTFIDS 5477
Score = 37.4 bits (85), Expect = 0.16
Identities = 27/106 (25%), Positives = 41/106 (38%), Gaps = 5/106 (4%)
Query: 479 VNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIR 538
V G + L G P P +TW D + +D + T+ + S + + +
Sbjct: 13702 VKAGTKIELPATVTGKPEPKITWTKADMILKQD-----KRITIENVPKKSTVTIVDSKRS 13756
Query: 539 DGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLI 584
D G Y A N+ G A +NV P A +IT V L+
Sbjct: 13757 DTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLL 13802
Score = 37.4 bits (85), Expect = 0.16
Identities = 80/372 (21%), Positives = 125/372 (33%), Gaps = 72/372 (19%)
Query: 299 AGHTVELPCTASGYPIPAIRWLKDGRPLP--ADSRWTKRITGLTISDLRTEDSGTYICEV 356
A T+ L T G P P ++W K L A T T L I ++ DSG Y +
Sbjct: 25121 ASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTL 25180
Query: 357 TNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVL 416
N GS A + V+D + + TIR + + L
Sbjct: 25181 ENNSGSKTAFVNVRVLD-----------------------SPSAPVNLTIREVKKDSVTL 25217
Query: 417 PDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTP---RIVSS 473
E I G + T I +++ AY +T F I L++G R+++S
Sbjct: 25218 SWEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTT--FRIENLQEGCSYYFRVLAS 25275
Query: 474 FSEKVVNPGEQFSLMCAAKGAPPP-------------TVTWALDDEPIVRDGSHRTNQYT 520
+ P E + ++ PP T+ W E DG + Y
Sbjct: 25276 NEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKW----EKPESDGGSKITGYV 25331
Query: 521 MSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEY---QARINVRG------------- 564
+ T S T Q++ T L EY A +N +G
Sbjct: 25332 VEMQTKGSEKWSTCTQVK---TLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIA 25388
Query: 565 -----PPSIRAMRNITAVAGRDTL-INCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGT 618
PS+ + V R+ L I+ G P ++ W KD L + R V + T
Sbjct: 25389 RDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKT 25448
Query: 619 LKLTDVQKGMDE 630
+ +++ E
Sbjct: 25449 VTSLSIKEASKE 25460
Score = 37.0 bits (84), Expect = 0.20
Identities = 44/207 (21%), Positives = 82/207 (39%), Gaps = 19/207 (9%)
Query: 1347 KAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNG 1406
K P + +S ++T + L + G V+W K+ E+ + + R+
Sbjct: 5607 KEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEE--VIRESENIRITFVEN 5664
Query: 1407 TLLLRAVKAE--DSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSK------TSASS 1458
L+ KAE ++G Y C N GG + L+V +P + V K T +
Sbjct: 5665 VATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVL----EPAVIVEKAGPMTVTVGET 5720
Query: 1459 ITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFIS--SSERSFKLDSLKCGTWYKVKLA 1516
TL S+ + + +S++ K F + SS R ++ GT+
Sbjct: 5721 CTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTY---TFQ 5777
Query: 1517 AKNSVGSGRISEIIEAKTHGREPSFSK 1543
+N+VG + +++ PSF++
Sbjct: 5778 VQNNVGKSSCTAVVDVSDRAVPPSFTR 5804
Score = 37.0 bits (84), Expect = 0.20
Identities = 77/309 (24%), Positives = 123/309 (39%), Gaps = 43/309 (13%)
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAE--DSGYYTCTATNT 1428
C+ G V W KDS + S +++ + + L +K + DSG YTC A N
Sbjct: 8174 CHVTGTQPIKVSWAKDSREIR---SGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNE 8230
Query: 1429 GGFDTIIVNLLVQ---VPPDQPRL---TVSKTSASSITLTWIPGDNGGSSIRGFVLQYSV 1482
G D+ L ++ +PP + TV +T +S L G GS + + +
Sbjct: 8231 VGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKL---EGRVAGS--QPITVAWYK 8285
Query: 1483 DNSEEWKDVFISSSERSFKLDSL-----KCGT----WYKVKLAAKNSVGSGRISEIIEAK 1533
+N E S+ E +FK ++L K G Y K++ N GS + I K
Sbjct: 8286 NNIEIQP---TSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVS--NDAGSALCTSSIVIK 8340
Query: 1534 THGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVL----EYRPKGTWAWQGLR 1589
+ P F DQHL S + L G PI L E +P ++
Sbjct: 8341 EPKKPPVF--DQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFS--F 8396
Query: 1590 ANSSGEVFLTELREATWYELRMRACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDV 1649
A+ + + L ++ +A + +A N AG + T T+ + P K A +G
Sbjct: 8397 ASGTAVLELRDVAKADSGDYVCKASNVAG-SDTTKSKVTIKDKPAVAPATKKAAVDG--- 8452
Query: 1650 KKLFTIGCP 1658
+LF + P
Sbjct: 8453 -RLFFVSEP 8460
Score = 37.0 bits (84), Expect = 0.20
Identities = 23/89 (25%), Positives = 39/89 (43%), Gaps = 7/89 (7%)
Query: 478 VVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQI 537
VV+ G ++ G PPPTVTW +++ + ++ + T + S M + Q
Sbjct: 16535 VVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAIS-------SSMVIKNCQR 16587
Query: 538 RDGGVYRCTARNLVGSAEYQARINVRGPP 566
GVY A+N G + ++V P
Sbjct: 16588 SHQGVYSLLAKNEAGERKKTIIVDVLDVP 16616
Score = 36.6 bits (83), Expect = 0.27
Identities = 25/89 (28%), Positives = 39/89 (43%), Gaps = 6/89 (6%)
Query: 297 VWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSR--WTKRITGLTISDLRTEDSGTYIC 354
V AG + + G P+P + W K L + T T LTI + DSG Y
Sbjct: 26198 VKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTL 26257
Query: 355 EVTNTFGSAEATGILMVID----PLHVTL 379
+ N +A T ++ V+D P ++T+
Sbjct: 26258 TIQNVLSAASLTLVVKVLDTPGPPTNITV 26286
Score = 36.2 bits (82), Expect = 0.35
Identities = 24/77 (31%), Positives = 35/77 (45%), Gaps = 10/77 (12%)
Query: 296 EVWAGHTVELPCTASGYPIPAIRWLKDGRPL--PADS--------RWTKRITGLTISDLR 345
+V AG V +P +G P+P I W K+ + P D+ ++ T L+I
Sbjct: 15409 KVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAV 15468
Query: 346 TEDSGTYICEVTNTFGS 362
ED GTY +N GS
Sbjct: 15469 REDKGTYTVTASNRLGS 15485
Score = 36.2 bits (82), Expect = 0.35
Identities = 24/85 (28%), Positives = 36/85 (42%), Gaps = 10/85 (11%)
Query: 297 VWAGHTVELPCTASGYPIPAIRWLKD--------GRPLPADSRWTKRITGLTISDLRTED 348
V AG T+ L G P P + W KD + D+R + +++ + D
Sbjct: 18213 VKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADS--SKFSLTKAKRSD 18270
Query: 349 SGTYICEVTNTFGSAEATGILMVID 373
G Y+ TNT GS A + V+D
Sbjct: 18271 GGKYVVTATNTAGSFVAYATVNVLD 18295
Score = 35.8 bits (81), Expect = 0.46
Identities = 21/71 (29%), Positives = 30/71 (42%), Gaps = 3/71 (4%)
Query: 297 VWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG---LTISDLRTEDSGTYI 353
V G T C +GYP P + W +G+ + R+ R G L I D ++ D+G
Sbjct: 1852 VLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLDIVDCKSYDTGEVK 1911
Query: 354 CEVTNTFGSAE 364
N G E
Sbjct: 1912 VTAENPEGVIE 1922
Score = 35.8 bits (81), Expect = 0.46
Identities = 28/89 (31%), Positives = 41/89 (46%), Gaps = 8/89 (8%)
Query: 299 AGHTVELPCTASGYPIPAIRWLKDGRPLP----ADSRWTKRITGLTISDLRTEDSGTYIC 354
AG T+ L G P P I W K L D + T T L ++ D+G YI
Sbjct: 19707 AGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYIL 19766
Query: 355 EVTNTFGSAEATGILMVID----PLHVTL 379
+ N+ G E T ++ V+D P++VT+
Sbjct: 19767 TLENSCGKKEYTIVVKVLDTPGPPVNVTV 19795
Score = 35.8 bits (81), Expect = 0.46
Identities = 22/77 (28%), Positives = 34/77 (44%), Gaps = 4/77 (5%)
Query: 311 GYPIPAIRWLKDGRPLPADSRWTKRI----TGLTISDLRTEDSGTYICEVTNTFGSAEAT 366
G P P++ W K PL D+R + T L + D + D+G Y + N G+ E T
Sbjct: 20008 GKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGT 20067
Query: 367 GILMVIDPLHVTLTPKK 383
+ V+ + P K
Sbjct: 20068 ISIKVVGKPGIPTGPIK 20084
Score = 35.8 bits (81), Expect = 0.46
Identities = 36/142 (25%), Positives = 55/142 (38%), Gaps = 20/142 (14%)
Query: 249 KEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTI------------LDGFHSQE 296
K+ + R + K +Y + N A S +P E+ ++ L G +Q
Sbjct: 28599 KQLTFTVERLVEKTEYEFRVKAKNDAGYS--EPREAFSSVIIKEPQIEPTADLTGITNQL 28656
Query: 297 VW--AGHTVELPCTASGYPIPAIRWLKDGRPLPADSR----WTKRITGLTISDLRTEDSG 350
+ AG + SG P P + W + L R TK T LT+ D DSG
Sbjct: 28657 ITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSG 28716
Query: 351 TYICEVTNTFGSAEATGILMVI 372
Y + NT G + ++VI
Sbjct: 28717 RYFLTLENTAGVKTFSVTVVVI 28738
Score = 35.0 bits (79), Expect = 0.78
Identities = 22/77 (28%), Positives = 32/77 (41%), Gaps = 3/77 (3%)
Query: 2006 LDPASKSLGLPHPGAPAAASTATLPQRTLAMPAPPAGTAPPAPGPTPAEPPTAPSAAPPA 2065
++P K LP AP + +P++ + PAP P P P +P P P A
Sbjct: 9282 VEPPPKVPELPEKPAPEEVAPVPIPKK-VEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAA 9340
Query: 2066 PSTEP--PRAGGPHTKM 2080
P P P+ P K+
Sbjct: 9341 PPKVPEVPKKPVPEEKI 9357
Score = 35.0 bits (79), Expect = 0.78
Identities = 32/124 (25%), Positives = 51/124 (41%), Gaps = 26/124 (20%)
Query: 498 TVTWALDDEPIVRDGSHRTNQYTMS------------DGTTISHMNVTGPQIRDGGVY-- 543
T+ W P +RDG + + Y S + + + +++ +++G Y
Sbjct: 18816 TLAWL----PPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKF 18871
Query: 544 RCTARNLVG-------SAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSI 596
R ARN VG Y+A+ + PP I IT AG+ I V G P+ +
Sbjct: 18872 RVAARNAVGVSLPREAEGVYEAKEQLL-PPKILMPEQITIKAGKKLRIEAHVYGKPHPTC 18930
Query: 597 KWYK 600
KW K
Sbjct: 18931 KWKK 18934
Score = 35.0 bits (79), Expect = 0.78
Identities = 41/178 (23%), Positives = 68/178 (38%), Gaps = 31/178 (17%)
Query: 389 GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNE-TLLITSAQKSHSGAYQCF 447
G+ V L + G P T+ W ++ L+ P E I + N TL + S + SG Y
Sbjct: 19310 GTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDY--- 19366
Query: 448 ATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVN-PGEQFSLMCAAKGAPPPTVTWALDDE 506
I E+ + ++ KV++ PG S+ + ++W E
Sbjct: 19367 ------------TITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSW----E 19410
Query: 507 PIVRDGSHRTNQYTMSDGTTI----SHMNVTGPQIRDGGVYRCTARNLVGSAEYQARI 560
P + DG Y + T + ++ T P + C+ L+ EYQ RI
Sbjct: 19411 PPLEDGGSEITNYIVDKRETSRPNWAQVSATVP------ITSCSVEKLIEGHEYQFRI 19462
Score = 34.7 bits (78), Expect = 1.0
Identities = 49/227 (21%), Positives = 79/227 (34%), Gaps = 32/227 (14%)
Query: 1862 ESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNENADSMTSMSTP 1921
E + EE+ E ++EE + +F E FI E + +
Sbjct: 10368 EVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEA 10427
Query: 1922 SEPGICRFTASPPK-PQDADR----GKNVAVPIPHRANKSDYCNLPLYAKSEAFFRKADG 1976
E + +PPK P+ +++ K +P + + +P E R +
Sbjct: 10428 EEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEE 10487
Query: 1977 REPCP-----VVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHPGAPAAASTATLPQ 2031
P V+PP+E + + + PA K P P P A +P+
Sbjct: 10488 PRVPPTKVPEVLPPKEV----------VPEKKVPVPPAKKPEA-PPPKVPEAPKEV-VPE 10535
Query: 2032 RTLAMPAPPAGTAPPAPGPTPAEPPTA-------PSAAPPAPSTEPP 2071
+ + +P P PP P E P A P A PP P + PP
Sbjct: 10536 KKVPVPPPKKPEVPPTKVP---EVPKAAVPEKKVPEAIPPKPESPPP 10579
Score = 34.7 bits (78), Expect = 1.0
Identities = 28/103 (27%), Positives = 44/103 (42%), Gaps = 9/103 (8%)
Query: 468 PRIVSSFSEKV-VNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTT 526
P + F +K+ + GE F+L G P P V+W D+ ++ D RT+ T
Sbjct: 16818 PTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLED--DRTHIKTTPATLA 16875
Query: 527 ISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV---RGPP 566
+ + + D G Y N GS + ++NV GPP
Sbjct: 16876 LEKIKA---KRSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPP 16915
Score = 34.7 bits (78), Expect = 1.0
Identities = 24/107 (22%), Positives = 43/107 (40%), Gaps = 5/107 (4%)
Query: 479 VNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIR 538
V G+ ++ KG P P +TW + + +VR+ + + + +
Sbjct: 17920 VRVGQTIRILARVKGRPEPDITWTKEGKVLVRE-----KRVDLIQDLPRVELQIKEAVRA 17974
Query: 539 DGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLIN 585
D G Y +A+N G A+ A +NV P +T V + I+
Sbjct: 17975 DHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTKENCTIS 18021
Score = 34.7 bits (78), Expect = 1.0
Identities = 25/96 (26%), Positives = 41/96 (42%), Gaps = 5/96 (5%)
Query: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNG-- 1406
P KI + ++ K + + C G+P P V W+ I G I
Sbjct: 33328 PPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRK--IHSQEQGRFHIENTDDL 33385
Query: 1407 -TLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQ 1441
TL++ V+ +D G YT + N G D+ VN+ ++
Sbjct: 33386 TTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421
Score = 34.3 bits (77), Expect = 1.3
Identities = 25/103 (24%), Positives = 43/103 (41%), Gaps = 8/103 (7%)
Query: 527 ISHMNVTGPQIRDGGVY--RCTARNLVGSAEYQARINVRG------PPSIRAMRNITAVA 578
+ + T + +GG Y R A N G ++ A + PPSI +
Sbjct: 16071 VEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEE 16130
Query: 579 GRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKL 621
G + I ++ G P+ ++ W+K PDN V+++ KL
Sbjct: 16131 GTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKL 16173
Score = 34.3 bits (77), Expect = 1.3
Identities = 27/93 (29%), Positives = 39/93 (41%), Gaps = 5/93 (5%)
Query: 286 PTI-LDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITGLTIS-- 342
PT+ LD + G L SG P P + W KD + D R + T T++
Sbjct: 16818 PTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALE 16877
Query: 343 --DLRTEDSGTYICEVTNTFGSAEATGILMVID 373
+ DSG Y V N+ GS + + V+D
Sbjct: 16878 KIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVD 16910
Score = 33.9 bits (76), Expect = 1.7
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 5/94 (5%)
Query: 1350 AKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT--NGT 1407
A+I++ ++T + R C++ G+P P V W + + + + H++ T T
Sbjct: 32561 ARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQ---VLSTSARHQVTTTKYKST 32617
Query: 1408 LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQ 1441
+ +V+A D G Y+ N+ G L +Q
Sbjct: 32618 FEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQ 32651
Score = 33.5 bits (75), Expect = 2.3
Identities = 27/105 (25%), Positives = 43/105 (40%), Gaps = 8/105 (7%)
Query: 478 VVNPGEQFSLMCAAKGAPPPTVTWALDD--EPIVRDGSHRTNQYTMSDGTTISHMNVTGP 535
V G Q + KG P P +W D + ++DG H + + S + + P
Sbjct: 15821 VCKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIII-P 15879
Query: 536 QIRDG--GVYRCTARNLVGSAEYQARI---NVRGPPSIRAMRNIT 575
+ + G Y TA+N G R+ +V GPP + +IT
Sbjct: 15880 ECKRSHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDIT 15924
Score = 33.1 bits (74), Expect = 3.0
Identities = 21/79 (26%), Positives = 34/79 (43%), Gaps = 3/79 (3%)
Query: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLL-LRAVKAEDSGYYTCTA 1425
+ + C G + +W KD ++ I S + H L + ++ ED+ YTC
Sbjct: 5254 IHMECKVSGSLPISAQWFKDGKE--ISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKV 5311
Query: 1426 TNTGGFDTIIVNLLVQVPP 1444
+N G D L V+ PP
Sbjct: 5312 SNVAGDDACSGILTVKEPP 5330
Score = 32.7 bits (73), Expect = 3.9
Identities = 29/123 (23%), Positives = 50/123 (40%), Gaps = 5/123 (4%)
Query: 1327 AVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKD 1386
AV G+ + + ++ I+ P+ TV +L G V W K+
Sbjct: 8227 AVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKN 8286
Query: 1387 SEDSAIPVSMDGHRLIHTNGTLLLRAVKA--EDSGYYTCTATNTGGFDTIIVNLLVQVPP 1444
+ + P S + N TL+L+ KA D+G YTC +N G +++++ P
Sbjct: 8287 NIEIQ-PTS--NCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPK 8343
Query: 1445 DQP 1447
P
Sbjct: 8344 KPP 8346
Score = 32.3 bits (72), Expect = 5.0
Identities = 29/122 (23%), Positives = 44/122 (36%), Gaps = 11/122 (9%)
Query: 285 IPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLK-------DGRPLPADSRWTKRIT 337
+P +D EV G V + G P P + W K + P+ D+ K +
Sbjct: 16116 MPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVV 16175
Query: 338 G----LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVI 393
L I R D+G Y N G+A L V+ + P K ++ +
Sbjct: 16176 DDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMT 16235
Query: 394 LS 395
LS
Sbjct: 16236 LS 16237
Score = 32.0 bits (71), Expect = 6.6
Identities = 22/70 (31%), Positives = 32/70 (45%), Gaps = 5/70 (7%)
Query: 1374 VGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNG--TLLLRAVKAEDSGYYTCTATNTGGF 1431
+GDP V+W D + + R+I+ G +L + DSG TC ATN G
Sbjct: 1729 IGDPTMVVEWLHDGKPLEAANRL---RMINEFGYCSLDYGVAYSRDSGIITCRATNKYGT 1785
Query: 1432 DTIIVNLLVQ 1441
D L+V+
Sbjct: 1786 DHTSATLIVK 1795
Score = 32.0 bits (71), Expect = 6.6
Identities = 16/57 (28%), Positives = 30/57 (52%), Gaps = 1/57 (1%)
Query: 389 GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGL-SNETLLITSAQKSHSGAY 444
G+ + L +TG PE I W + ++ D+ I+I + T+ I +++S +G Y
Sbjct: 13705 GTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTY 13761
Score = 32.0 bits (71), Expect = 6.6
Identities = 30/131 (22%), Positives = 53/131 (40%), Gaps = 18/131 (13%)
Query: 388 IGSTVILSCALTGSPEFTIRWYRNTELVLPDEAIS-IRGLSNETLLITSAQKSHSGAYQC 446
+G T+ + + G PE I W + ++++ ++ + I+ L L I A ++ G Y
Sbjct: 17922 VGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYII 17981
Query: 447 FATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDE 506
A + AQ AI+ + D PG +L T++W +
Sbjct: 17982 SAKNSSGHAQGSAIVNVLD--------------RPGPCQNLKVTNVTKENCTISW---EN 18024
Query: 507 PIVRDGSHRTN 517
P+ GS TN
Sbjct: 18025 PLDNGGSEITN 18035
Score = 32.0 bits (71), Expect = 6.6
Identities = 35/112 (31%), Positives = 55/112 (49%), Gaps = 15/112 (13%)
Query: 565 PPSIR---AMRNITAV-AGRDTLINCRVIGYPYYSIKWYKDALLL-PDNHRQVVFENG-- 617
PP I AM+++ V AG + ++ V G P ++ W KD LL P ++ +
Sbjct: 19292 PPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLC 19351
Query: 618 TLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI 669
TL+L V + D G+Y + S S+S + +KV L +P PPAS+
Sbjct: 19352 TLELFSVNR-KDSGDY---TITAENSSGSKSATIKLKV--LDKP--GPPASV 19395
Score = 32.0 bits (71), Expect = 6.6
Identities = 23/92 (25%), Positives = 36/92 (39%), Gaps = 8/92 (8%)
Query: 478 VVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQI 537
VV+ GE F + G P PT+ W D+ + T + + + ++V
Sbjct: 22554 VVHAGESFKVDADIYGKPIPTIQWIKGDQEL-----SNTARLEIKSTDFATSLSVKDAVR 22608
Query: 538 RDGGVYRCTARNLVGSAEYQARINV---RGPP 566
D G Y A+N+ G + V GPP
Sbjct: 22609 VDSGNYILKAKNVAGERSVTVNVKVLDRPGPP 22640
Score = 32.0 bits (71), Expect = 6.6
Identities = 23/77 (29%), Positives = 35/77 (45%), Gaps = 2/77 (2%)
Query: 299 AGHTVELPCTASGYPIPAIRWLK-DGRPLPADS-RWTKRITGLTISDLRTEDSGTYICEV 356
AG ++ L G P P ++W K DG A T T L + ++ DSG Y +
Sbjct: 22956 AGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTL 23015
Query: 357 TNTFGSAEATGILMVID 373
N+ G+ A + V+D
Sbjct: 23016 ENSSGTKSAFVTVRVLD 23032
Score = 31.6 bits (70), Expect = 8.6
Identities = 19/60 (31%), Positives = 26/60 (43%), Gaps = 1/60 (1%)
Query: 574 ITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQ-KGMDEGE 632
+ + G CRV GYP + WY + L+ + R V +G L V K D GE
Sbjct: 1850 VRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLDIVDCKSYDTGE 1909
Score = 31.6 bits (70), Expect = 8.6
Identities = 15/59 (25%), Positives = 30/59 (50%), Gaps = 2/59 (3%)
Query: 363 AEATGILMVIDPLHV--TLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDE 419
+ AT +DP+ + L+ G + L +++GSP TI W ++ +++P+E
Sbjct: 14666 SRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEE 14724
Score = 31.6 bits (70), Expect = 8.6
Identities = 21/79 (26%), Positives = 34/79 (43%), Gaps = 2/79 (2%)
Query: 297 VWAGHTVELPCTASGYPIPAIRWLKDGRPLP--ADSRWTKRITGLTISDLRTEDSGTYIC 354
V AG ++ + G P P + W KD L A+ T+ T L I + D+G ++
Sbjct: 20788 VRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVM 20847
Query: 355 EVTNTFGSAEATGILMVID 373
+ N G + V+D
Sbjct: 20848 TIENPAGKKSGFVNVRVLD 20866
Score = 31.6 bits (70), Expect = 8.6
Identities = 22/79 (27%), Positives = 32/79 (40%), Gaps = 4/79 (5%)
Query: 299 AGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG----LTISDLRTEDSGTYIC 354
AG + L G P P I W K + L + + + TG I DSG Y
Sbjct: 29061 AGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTL 29120
Query: 355 EVTNTFGSAEATGILMVID 373
V N G+ + ++ V+D
Sbjct: 29121 TVKNASGTKAVSVMVKVLD 29139
Score = 31.6 bits (70), Expect = 8.6
Identities = 27/100 (27%), Positives = 43/100 (43%), Gaps = 5/100 (5%)
Query: 266 GETRQSNGARLSVTDPAESIPTILDGFHSQEVWA--GHTVELPCTASGYPIPAIRWLKDG 323
GE + G + VT+ E LD + + ++ G + L G P P +W K+G
Sbjct: 30116 GEPAEVPGT-VKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEG 30174
Query: 324 RPLP--ADSRWTKRITGLTISDLRTEDSGTYICEVTNTFG 361
+ + A ++ T L I + DSGTY + N G
Sbjct: 30175 QDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENKCG 30214
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 238 bits (608), Expect = 4e-62
Identities = 228/907 (25%), Positives = 373/907 (41%), Gaps = 97/907 (10%)
Query: 415 VLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSF 474
++PD RG + T + TS +S Y R+ ED PRIV
Sbjct: 27 LIPDPEDVERGNDHGTPIPTSDNDDNSLGYTGSRLRQ------------EDFPPRIVEHP 74
Query: 475 SEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH-RTNQYTMSDGTTISHMNVT 533
S+ +V+ GE +L C A+G P PT+ W E + D R+++ + G+ V
Sbjct: 75 SDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 134
Query: 534 GPQIR-DGGVYRCTARNLVGSA-EYQARINV-------RGPPSIRAMRNITAVAGRDTLI 584
G + R D GVY C ARN +G A + A + V R PS ++ G ++
Sbjct: 135 GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-----DVMVAVGEPAVM 189
Query: 585 NCRVI-GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL 643
C+ G+P +I W KD L D ++ G L +T +K D G+Y+C
Sbjct: 190 ECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS-DAGKYVCVGTNMVGE 248
Query: 644 SISQSVHVAV-KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKD-GQVIISGS 701
S+ + V + P ++ ++ C +P + WRKD G++ S
Sbjct: 249 RESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT-VRWRKDDGELPKSRY 307
Query: 702 GVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDG 761
+ + +L+I V+ G+YTC+A N L V+ PP FVV+P +Q
Sbjct: 308 EIRDDH-----TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVV 362
Query: 762 IYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEED 821
G+ C G P P + W+ Y P + R + L I +V D
Sbjct: 363 ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSD 422
Query: 822 IGYYLCQASNGVGTDISKSMFLTVKI-----PAMITSHP-NTTIAIKGHAKELNCTARGE 875
+GYY+CQ N G+ I+K+ + P +I P N T+A+ G L+C A G
Sbjct: 423 VGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG-TFVLSCVATGS 481
Query: 876 RPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGE 935
I W K ++ I +NG L+++ A GD+ ++C A GE
Sbjct: 482 PVPTILWRKDGVLVS---TQDSRIKQLENG-----VLQIRYAKLGDTGRYTCIASTPSGE 533
Query: 936 DRGLIQLTVQE----------------PPDPPELEIREVKARSMNLRWTQRFDGNSIITG 979
+ VQE P P + E+ +V ++ L W + + T
Sbjct: 534 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 593
Query: 980 FDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSK-ELT 1038
+ IE + + ++ N+ + I L P ++Y + + N G S+PS+
Sbjct: 594 YIIEAFSHASGSSWQTVAENVK--TETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDP 651
Query: 1039 ISTEEAAPDGPPMD---------------VTLQPVTSQSIQVTWKAPKKELQNGVIRGYQ 1083
+ T++ P +D ++S SI+V W + Q+ I+GY+
Sbjct: 652 VKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQGYK 708
Query: 1084 IGYRENSPG-SNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEIN 1142
I YR + + + E++ + V + +L+K Y + + F G S
Sbjct: 709 ILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIKARPFFNEFQGADSEIKF 767
Query: 1143 ATTLEDVPSQPPENVRALSITSD--VAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWG 1200
A TLE+ PS PP+ V + ++SW PP T NG+++ Y+V W L + +
Sbjct: 768 AKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV--WCLGNETRYH 825
Query: 1201 EMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAV 1260
+ + + V + + YSV+V A T AG GV+S +IQ D G P +
Sbjct: 826 INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL--DAHGNPVSPEDQ 883
Query: 1261 PSSASSV 1267
S A +
Sbjct: 884 VSLAQQI 890
Score = 144 bits (362), Expect = 1e-33
Identities = 145/488 (29%), Positives = 205/488 (42%), Gaps = 68/488 (13%)
Query: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP--------------LPADSR 331
P I++ V G L C A G P P I W K G LP+ S
Sbjct: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
Query: 332 WTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH--VTLTPKKLKTGIG 389
+ RI S D G Y+C N G A + + + L P + +G
Sbjct: 128 FFLRIVHGRKS---RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 184
Query: 390 STVILSC-ALTGSPEFTIRWYRN-TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCF 447
++ C G PE TI W ++ + L DE I+IRG L+IT +KS +G Y C
Sbjct: 185 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG---GKLMITYTRKSDAGKYVCV 241
Query: 448 AT-----RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
T R+++ A+ + LE P V S V + C A+G P PTV W
Sbjct: 242 GTNMVGERESEVAE---LTVLE--RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
Query: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562
D DG ++Y + D T+ VT D G Y C A N+VG AE A + V
Sbjct: 297 KD------DGELPKSRYEIRDDHTLKIRKVTA---GDMGSYTCVAENMVGKAEASATLTV 347
Query: 563 RGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA---LLL-----PDNHRQVV 613
+ PP + R+ GR C G P +I W ++ LL + R V
Sbjct: 348 QEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 407
Query: 614 FENGTLKLTDVQKGMDEGEYLC-------SVLIQPQLSISQSVHVAVKVPPLIQ--PFEF 664
+ G L +T+VQ+ D G Y+C S++ + L ++ +A + PP+I+ P
Sbjct: 408 SQTGDLTITNVQRS-DVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQ 464
Query: 665 PPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHN 724
A G + + CV + +P I WRKDG V++S I+ E LQI L
Sbjct: 465 TVAVDGTFV-LSCVATGSPVP-TILWRKDG-VLVSTQDSRIKQLE-NGVLQIRYAKLGDT 520
Query: 725 GNYTCIAS 732
G YTCIAS
Sbjct: 521 GRYTCIAS 528
Score = 135 bits (340), Expect = 4e-31
Identities = 235/1024 (22%), Positives = 377/1024 (36%), Gaps = 133/1024 (12%)
Query: 345 RTEDSGTYICEVTNTFGSAEATGILMVID--PLHVTLTPKKLKTGIGSTVILSCALTGSP 402
R D GT I N S TG + + P + P L G L+C G P
Sbjct: 36 RGNDHGTPIPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRP 95
Query: 403 EFTIRWYRNTELVLPDE------AISIRGLSNETLLITSAQKSH--SGAYQCFATRKAQT 454
TI WY+ E V D+ + + S L I +KS G Y C A
Sbjct: 96 TPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGE 155
Query: 455 A----QDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMC-AAKGAPPPTVTWALDDEPIV 509
A + L D + S+ +V GE + C +G P PT++W D P+
Sbjct: 156 AVSHNASLEVAILRDD---FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL- 211
Query: 510 RDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQ-ARINVRGPPS- 567
+ + T+ G + +T + D G Y C N+VG E + A + V PS
Sbjct: 212 ---DDKDERITIRGG----KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSF 264
Query: 568 IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKG 627
++ N+ C G P +++W KD LP + R + ++ TLK+ V G
Sbjct: 265 VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAG 323
Query: 628 MDEGEYLCSVLIQPQLSISQSVHVAVKVPP--LIQPFEFPPASIGQLLYIPCVVSSGDMP 685
D G Y C V S + V+ PP +++P + ++G+ + C + P
Sbjct: 324 -DMGSYTC-VAENMVGKAEASATLTVQEPPHFVVKPRD-QVVALGRTVTFQCEATGNPQP 380
Query: 686 IRITWRKDGQVIISGSGVTIESKEFMS-----SLQISSVSLKHNGNYTCIASNAAATVSR 740
I WR++G + S +S S L I++V G Y C N A ++
Sbjct: 381 -AIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT 439
Query: 741 ERQLIV------RVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQ 794
+ L V R PP P NQ VL+C G P P ++W+ + Q
Sbjct: 440 KAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQD 499
Query: 795 YHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVK---IPAMI 851
RI+ L N L IR+ D G Y C AS G + + S ++ V+ +P
Sbjct: 500 -------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG-EATWSAYIEVQEFGVPVQ- 550
Query: 852 TSHPNTTIAIKGHAKELNCTARGERPIIIRWEKG-DTVIDPDR--VMRYAIATKDNGDEV 908
P I + T + + W+ ++ P + ++ A+ + V
Sbjct: 551 PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTV 610
Query: 909 VSTLK-----LKPADRGDSVFFSCHAINSYG------------------EDRGLIQLTVQ 945
+K +K F A N+YG +G+ VQ
Sbjct: 611 AENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQ 670
Query: 946 EPPDPPELEIRE---VKARSMNLRWTQRFDGNSIITGFDIEYK------NKSDSWDFKQS 996
L + + + S+ + WT + I G+ I Y+ +SD F+
Sbjct: 671 RELGNAVLHLHNPTVLSSSSIEVHWTVD-QQSQYIQGYKILYRPSGANHGESDWLVFEVR 729
Query: 997 TRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTL- 1055
T P N I DL Y I+ F + S+ T E AP PP VT+
Sbjct: 730 T----PAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVS 785
Query: 1056 -QPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLD 1114
+I V+W+ P ++ QNG+++ Y++ G+ +Y I G + +
Sbjct: 786 KNDGNGTAILVSWQPPPEDTQNGMVQEYKVW----CLGNETRYHI-NKTVDGSTFSVVIP 840
Query: 1115 NLKKFAQYGVVVQAFNRAGTG-PSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSE 1173
L +Y V V A AG+G S + P P + V SDV +
Sbjct: 841 FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVV----KQ 896
Query: 1174 PPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYS-VQVLAYTQ 1232
P G ++ +S+++ + +T+T G+ K +++ + Y +
Sbjct: 897 PAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTST-----YAGIRKVPSFTFTPTVTYQR 951
Query: 1233 AGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPN--GVIRKYTIFCSS 1290
G+ V S G G+ + A+ WL T PN +I C +
Sbjct: 952 GGEAVSS------------GGRPGLLNISEPAAQ---PWLADTWPNTGNNHNDCSISCCT 996
Query: 1291 PGSG 1294
G+G
Sbjct: 997 AGNG 1000
Score = 132 bits (331), Expect = 5e-30
Identities = 186/833 (22%), Positives = 322/833 (38%), Gaps = 112/833 (13%)
Query: 579 GRDTLINCRVIGYPYYSIKWYKDALLL------PDNHRQVVFENGTLKLTDVQKGM---- 628
G +NC+ G P +I+WYK + P +HR ++ +G+L + G
Sbjct: 82 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL-PSGSLFFLRIVHGRKSRP 140
Query: 629 DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPA----SIGQLLYIPCVVSSGDM 684
DEG Y+C + + L + S + +++V L F P+ ++G+ + C G
Sbjct: 141 DEGVYVC--VARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHP 198
Query: 685 PIRITWRKDGQVIIS-GSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRE-R 742
I+W+KDG + +TI + M I+ G Y C+ +N E
Sbjct: 199 EPTISWKKDGSPLDDKDERITIRGGKLM----ITYTRKSDAGKYVCVGTNMVGERESEVA 254
Query: 743 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
+L V P FV +P+N + C G P P V W+ G +Y
Sbjct: 255 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY------- 307
Query: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIK 862
+I + +L IR V D+G Y C A N VG S LTV+ P P +
Sbjct: 308 --EIRDDHTLKIRKVTAGDMGSYTCVAENMVGK-AEASATLTVQEPPHFVVKPRDQVVAL 364
Query: 863 GHAKELNCTARGERPIIIRWEKGDT------VIDPDRVMRYAIATKDNGDEVVSTLKLKP 916
G C A G I W + + P R++++ GD ++ ++
Sbjct: 365 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS--QTGDLTITNVQ--- 419
Query: 917 ADRGDSVFFSCHAINSYGE--DRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRFDGN 974
R D ++ C +N G + +++T PP + R + T DG
Sbjct: 420 --RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV------IRQGPVNQTVAVDGT 471
Query: 975 SIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGR---- 1030
+++ + W + + + I L V IR GR
Sbjct: 472 FVLSCVATGSPVPTILW----RKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCI 526
Query: 1031 -SEPSKELTIST-----EEAAPDGPPM--DVTLQP----------VTSQSIQVTWKAPKK 1072
S PS E T S E P PP D L P V+ ++ ++W+
Sbjct: 527 ASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP--- 583
Query: 1073 ELQNGVI-RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 1131
L +G Y I ++ GS+ Q +K +E + LK A Y +V+A N
Sbjct: 584 NLNSGATPTSYIIEAFSHASGSSWQTVAENVK----TETSAIKGLKPNAIYLFLVRAANA 639
Query: 1132 AGTGPSSSEINATTLEDV-PSQPPENVRALSITSDVAVISWSEPPRSTLNGV-------- 1182
G S + +DV P+ + + + AV+ P + + +
Sbjct: 640 YGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQ 699
Query: 1183 ----LKGYRVIF---WSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGD 1235
++GY++++ + + + +W + T + V + + K NY ++ +
Sbjct: 700 QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQ 759
Query: 1236 GVRSSVLYIQTKEDVPG-PPAGIKAVPS--SASSVVVSWLPPTKP--NGVIRKYTIFCSS 1290
G S + + +T E+ P PP G+ + + ++++VSW PP + NG++++Y ++C
Sbjct: 760 GADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLG 819
Query: 1291 PGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIE 1343
+ + S + I L G +Y + VAA T AG G SE I+
Sbjct: 820 NETRYHINKTVDGSTFSVV--IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQ 870
Score = 131 bits (330), Expect = 6e-30
Identities = 133/477 (27%), Positives = 193/477 (40%), Gaps = 42/477 (8%)
Query: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIH-------DN 159
C A G P+ + WY G+ + H L P F +H +
Sbjct: 89 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHR----MLLPSGSLFFLRIVHGRKSRPDEG 143
Query: 160 DYFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218
Y C A N G+ S N ++ A+ R+ + D G AV +C P E
Sbjct: 144 VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE--PT 201
Query: 219 VSWEKDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
+SW+KD S + + IT GG L I+ +K DA Y C+ + GE R+S A L+
Sbjct: 202 ISWKKDG-SPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTNMV-GE-RESEVAELT 257
Query: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337
V + P+ + + V + E C A G P+P +RW KD LP +
Sbjct: 258 VLER----PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH 313
Query: 338 GLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCA 397
L I + D G+Y C N G AEA+ L V +P H + P+ +G TV C
Sbjct: 314 TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCE 373
Query: 398 LTGSPEFTIRWYRNTELVL-----PDEAISIRGLSNE-TLLITSAQKSHSGAYQCFATRK 451
TG+P+ I W R L P ++ S +S L IT+ Q+S G Y C
Sbjct: 374 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 433
Query: 452 AQTAQDFAIIALED-----GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDE 506
A + A + + D P I + V F L C A G+P PT+ W D
Sbjct: 434 AGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR-KDG 492
Query: 507 PIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR 563
+V R Q + +G + + ++ D G Y C A G A + A I V+
Sbjct: 493 VLVSTQDSRIKQ--LENGV----LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
Score = 102 bits (253), Expect = 5e-21
Identities = 93/324 (28%), Positives = 140/324 (43%), Gaps = 29/324 (8%)
Query: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 220
Y C N G+ S + + R + R + + A FKC + + V V
Sbjct: 238 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKC---EARGDPVPTVR 294
Query: 221 WEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD 280
W KD + P+ R+ I L I V D + +Y C+ ++ + A L+V +
Sbjct: 295 WRKDDGEL-PKSRYEIRDDHTLKIRKVTAGD-MGSYTCVAENMVG---KAEASATLTVQE 349
Query: 281 PAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDG--------RPLPADSRW 332
P + D Q V G TV C A+G P PAI W ++G +P + SR+
Sbjct: 350 PPHFVVKPRD----QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 405
Query: 333 TKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVID------PLHVTLTPKKLK 385
+ TG LTI++++ D G YIC+ N GS L V D P + P
Sbjct: 406 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 465
Query: 386 TGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 445
+ T +LSC TGSP TI W ++ LV ++ I+ L N L I A+ +G Y
Sbjct: 466 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYT 524
Query: 446 CFATRKAQTAQDFAIIALED-GTP 468
C A+ + A A I +++ G P
Sbjct: 525 CIASTPSGEATWSAYIEVQEFGVP 548
Score = 69.3 bits (168), Expect = 4e-11
Identities = 76/310 (24%), Positives = 121/310 (39%), Gaps = 44/310 (14%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT-NGTLLLRAVKAEDSGYYTCTATN 1427
L C + G P P + W KD + VS R+ NG L +R K D+G YTC A+
Sbjct: 474 LSCVATGSPVPTILWRKDG----VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 529
Query: 1428 TGGFDTIIVNLLVQ---VPPDQPRLT-------------VSKTSASSITLTWIPGDNGGS 1471
G T + VQ VP PR T V+ S +++TL+W P N G+
Sbjct: 530 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 589
Query: 1472 SIRGFVLQ-YSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEII 1530
+ ++++ +S + W+ V + + + LK Y + A N+ G S+I
Sbjct: 590 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 649
Query: 1531 E-AKTHGREPSFSKDQHLFTHINSTHARLNLQG------------W--NNGGCPITAIVL 1575
+ KT P+ H +A L+L W + I +
Sbjct: 650 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 709
Query: 1576 EYRPKGT------WAWQGLRANSSGEVFLTELREATWYELRMRA-CNSAGCGNETAQFAT 1628
YRP G W +R + V + +LR+ YE++ R N + +FA
Sbjct: 710 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 769
Query: 1629 LDYDGSTIPP 1638
+ + PP
Sbjct: 770 TLEEAPSAPP 779
Score = 50.8 bits (120), Expect = 1e-05
Identities = 32/74 (43%), Positives = 36/74 (48%), Gaps = 5/74 (6%)
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
C + GDP P V+W KD D +P S R HT L +R V A D G YTC A N G
Sbjct: 283 CEARGDPVPTVRWRKD--DGELPKSRYEIRDDHT---LKIRKVTAGDMGSYTCVAENMVG 337
Query: 1431 FDTIIVNLLVQVPP 1444
L VQ PP
Sbjct: 338 KAEASATLTVQEPP 351
Score = 45.8 bits (107), Expect = 4e-04
Identities = 72/359 (20%), Positives = 127/359 (35%), Gaps = 51/359 (14%)
Query: 1294 GQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAG----KAP 1349
G+ S YE + +I + G A G+ +S +T++ K
Sbjct: 300 GELPKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 358
Query: 1350 AKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAI----PVSMDGHRLIHTN 1405
++++ G TVT C + G+P PA+ W ++ + + P +
Sbjct: 359 DQVVALGRTVT--------FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 410
Query: 1406 GTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP---PDQPRLTVSKTSASSITLT 1462
G L + V+ D GYY C N G +II ++V D+P + + +
Sbjct: 411 GDLTITNVQRSDVGYYICQTLNVAG--SIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 468
Query: 1463 WIPGDNGGSSIRGFVLQYSVDNSEEWK--DVFISSSERSFK--------LDSLKCGTWYK 1512
G+ + V S + W+ V +S+ + K + K G +
Sbjct: 469 ------DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGR 522
Query: 1513 VKLAAKNSVGSGRISEIIEAKTHG--REPSFSKDQHLF---------THINSTHARLNLQ 1561
A G S IE + G +P D +L T ++ L+ Q
Sbjct: 523 YTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 582
Query: 1562 -GWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEV-FLTELREATWYELRMRACNSAG 1618
N+G P + I+ + +WQ + N E + L+ Y +RA N+ G
Sbjct: 583 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYG 641
Score = 37.0 bits (84), Expect = 0.20
Identities = 34/157 (21%), Positives = 58/157 (36%), Gaps = 14/157 (8%)
Query: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATN-TGGFDT 1433
G P P + W KD P+ R+ G L++ + D+G Y C TN G ++
Sbjct: 196 GHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 251
Query: 1434 IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGF---VLQYSVDNSEEWKD 1490
+ L V P + S++ +T RG +++ D+ E K
Sbjct: 252 EVAELTVLERPSFVK------RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 305
Query: 1491 VFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRIS 1527
+ + + K+ + G A+N VG S
Sbjct: 306 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS 342
Score = 34.7 bits (78), Expect = 1.0
Identities = 26/88 (29%), Positives = 37/88 (42%), Gaps = 12/88 (13%)
Query: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE----DSAIPVSMDGHRLIHT 1404
P +I+ + + L C + G P P ++W K E D P S HR++
Sbjct: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLP 123
Query: 1405 NGTL-LLRAVKAE----DSGYYTCTATN 1427
+G+L LR V D G Y C A N
Sbjct: 124 SGSLFFLRIVHGRKSRPDEGVYVCVARN 151
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 237 bits (605), Expect = 8e-62
Identities = 218/858 (25%), Positives = 357/858 (41%), Gaps = 85/858 (9%)
Query: 464 EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH-RTNQYTMS 522
ED PRIV S+ +V+ GE +L C A+G P PT+ W E + D R+++ +
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
Query: 523 DGTTISHMNVTGPQIR-DGGVYRCTARNLVGSA-EYQARINV-------RGPPSIRAMRN 573
G+ V G + R D GVY C ARN +G A + A + V R PS +
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-----D 139
Query: 574 ITAVAGRDTLINCRVI-GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632
+ G ++ C+ G+P +I W KD L D ++ G L +T +K D G+
Sbjct: 140 VMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS-DAGK 198
Query: 633 YLCSVLIQPQLSISQSVHVAV-KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWR 691
Y+C S+ + V + P ++ ++ C +P + WR
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT-VRWR 257
Query: 692 KD-GQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPP 750
KD G++ S + + +L+I V+ G+YTC+A N L V+ PP
Sbjct: 258 KDDGELPKSRYEIRDDH-----TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 312
Query: 751 RFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNS 810
FVV+P +Q G+ C G P P + W+ Y P + R +
Sbjct: 313 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 372
Query: 811 SLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI-----PAMITSHP-NTTIAIKGH 864
L I +V D+GYY+CQ N G+ I+K+ + P +I P N T+A+ G
Sbjct: 373 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG- 431
Query: 865 AKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVF 924
L+C A G I W K ++ I +NG L+++ A GD+
Sbjct: 432 TFVLSCVATGSPVPTILWRKDGVLVS---TQDSRIKQLENG-----VLQIRYAKLGDTGR 483
Query: 925 FSCHAINSYGEDRGLIQLTVQE----------------PPDPPELEIREVKARSMNLRWT 968
++C A GE + VQE P P + E+ +V ++ L W
Sbjct: 484 YTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 543
Query: 969 QRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKI 1028
+ + T + IE + + ++ N+ + I L P ++Y + + N
Sbjct: 544 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVK--TETSAIKGLKPNAIYLFLVRAANAY 601
Query: 1029 GRSEPSK-ELTISTEEAAPDGPPMD---------------VTLQPVTSQSIQVTWKAPKK 1072
G S+PS+ + T++ P +D ++S SI+V W
Sbjct: 602 GISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV--- 658
Query: 1073 ELQNGVIRGYQIGYRENSPG-SNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 1131
+ Q+ I+GY+I YR + + + E++ + V + +L+K Y + + F
Sbjct: 659 DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIKARPFFN 717
Query: 1132 AGTGPSSSEINATTLEDVPSQPPENVRALSITSD--VAVISWSEPPRSTLNGVLKGYRVI 1189
G S A TLE+ PS PP+ V + ++SW PP T NG+++ Y+V
Sbjct: 718 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV- 776
Query: 1190 FWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKED 1249
W L + + + + + V + + YSV+V A T AG GV+S +IQ D
Sbjct: 777 -WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL--D 833
Query: 1250 VPGPPAGIKAVPSSASSV 1267
G P + S A +
Sbjct: 834 AHGNPVSPEDQVSLAQQI 851
Score = 144 bits (362), Expect = 1e-33
Identities = 145/488 (29%), Positives = 205/488 (42%), Gaps = 68/488 (13%)
Query: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP--------------LPADSR 331
P I++ V G L C A G P P I W K G LP+ S
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 332 WTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH--VTLTPKKLKTGIG 389
+ RI S D G Y+C N G A + + + L P + +G
Sbjct: 89 FFLRIVHGRKS---RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
Query: 390 STVILSC-ALTGSPEFTIRWYRN-TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCF 447
++ C G PE TI W ++ + L DE I+IRG L+IT +KS +G Y C
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG---GKLMITYTRKSDAGKYVCV 202
Query: 448 AT-----RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
T R+++ A+ + LE P V S V + C A+G P PTV W
Sbjct: 203 GTNMVGERESEVAE---LTVLE--RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562
D DG ++Y + D T+ VT D G Y C A N+VG AE A + V
Sbjct: 258 KD------DGELPKSRYEIRDDHTLKIRKVTA---GDMGSYTCVAENMVGKAEASATLTV 308
Query: 563 RGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA---LLL-----PDNHRQVV 613
+ PP + R+ GR C G P +I W ++ LL + R V
Sbjct: 309 QEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 368
Query: 614 FENGTLKLTDVQKGMDEGEYLC-------SVLIQPQLSISQSVHVAVKVPPLIQ--PFEF 664
+ G L +T+VQ+ D G Y+C S++ + L ++ +A + PP+I+ P
Sbjct: 369 SQTGDLTITNVQRS-DVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQ 425
Query: 665 PPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHN 724
A G + + CV + +P I WRKDG V++S I+ E LQI L
Sbjct: 426 TVAVDGTFV-LSCVATGSPVP-TILWRKDG-VLVSTQDSRIKQLE-NGVLQIRYAKLGDT 481
Query: 725 GNYTCIAS 732
G YTCIAS
Sbjct: 482 GRYTCIAS 489
Score = 133 bits (334), Expect = 2e-30
Identities = 226/993 (22%), Positives = 366/993 (36%), Gaps = 131/993 (13%)
Query: 374 PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDE------AISIRGLS 427
P + P L G L+C G P TI WY+ E V D+ + + S
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 428 NETLLITSAQKSH--SGAYQCFATRKAQTA----QDFAIIALEDGTPRIVSSFSEKVVNP 481
L I +KS G Y C A A + L D + S+ +V
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD---FRQNPSDVMVAV 144
Query: 482 GEQFSLMC-AAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDG 540
GE + C +G P PT++W D P+ + + T+ G + +T + D
Sbjct: 145 GEPAVMECQPPRGHPEPTISWKKDGSPL----DDKDERITIRGG----KLMITYTRKSDA 196
Query: 541 GVYRCTARNLVGSAEYQ-ARINVRGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKW 598
G Y C N+VG E + A + V PS ++ N+ C G P +++W
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 599 YKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPP- 657
KD LP + R + ++ TLK+ V G D G Y C V S + V+ PP
Sbjct: 257 RKDDGELPKS-RYEIRDDHTLKIRKVTAG-DMGSYTC-VAENMVGKAEASATLTVQEPPH 313
Query: 658 -LIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMS---- 712
+++P + ++G+ + C + P I WR++G + S +S S
Sbjct: 314 FVVKPRD-QVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVSQT 371
Query: 713 -SLQISSVSLKHNGNYTCIASNAAATVSRERQLIV------RVPPRFVVQPNNQDGIYGK 765
L I++V G Y C N A ++ + L V R PP P NQ
Sbjct: 372 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 431
Query: 766 AGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYY 825
VL+C G P P ++W+ + Q RI+ L N L IR+ D G Y
Sbjct: 432 TFVLSCVATGSPVPTILWRKDGVLVSTQD-------SRIKQLENGVLQIRYAKLGDTGRY 484
Query: 826 LCQASNGVGTDISKSMFLTVK---IPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRW 882
C AS G + + S ++ V+ +P P I + T + + W
Sbjct: 485 TCIASTPSG-EATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 542
Query: 883 EKG-DTVIDPDR--VMRYAIATKDNGDEVVSTLK-----LKPADRGDSVFFSCHAINSYG 934
+ ++ P + ++ A+ + V +K +K F A N+YG
Sbjct: 543 QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYG 602
Query: 935 ------------------EDRGLIQLTVQEPPDPPELEIRE---VKARSMNLRWTQRFDG 973
+G+ VQ L + + + S+ + WT
Sbjct: 603 ISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-QQ 661
Query: 974 NSIITGFDIEYK------NKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNK 1027
+ I G+ I Y+ +SD F+ T P N I DL Y I+ F
Sbjct: 662 SQYIQGYKILYRPSGANHGESDWLVFEVRT----PAKNSVVIPDLRKGVNYEIKARPFFN 717
Query: 1028 IGRSEPSKELTISTEEAAPDGPPMDVTL--QPVTSQSIQVTWKAPKKELQNGVIRGYQIG 1085
+ S+ T E AP PP VT+ +I V+W+ P ++ QNG+++ Y++
Sbjct: 718 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 777
Query: 1086 YRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINAT 1144
G+ +Y I G + + L +Y V V A AG+G S +
Sbjct: 778 ----CLGNETRYHI-NKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 832
Query: 1145 TLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQN 1204
P P + V SDV +P G ++ +S+++ +
Sbjct: 833 DAHGNPVSPEDQVSLAQQISDVV----KQPAFIAGIGAACWIILMVFSIWLYRHRKKRNG 888
Query: 1205 ITTTRERVELRGMEKFTNYS-VQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSS 1263
+T+T G+ K +++ + Y + G+ V S G G+ +
Sbjct: 889 LTST-----YAGIRKVPSFTFTPTVTYQRGGEAVSS------------GGRPGLLNISEP 931
Query: 1264 ASSVVVSWLPPTKPN--GVIRKYTIFCSSPGSG 1294
A+ WL T PN +I C + G+G
Sbjct: 932 AAQ---PWLADTWPNTGNNHNDCSISCCTAGNG 961
Score = 132 bits (331), Expect = 5e-30
Identities = 186/833 (22%), Positives = 322/833 (38%), Gaps = 112/833 (13%)
Query: 579 GRDTLINCRVIGYPYYSIKWYKDALLL------PDNHRQVVFENGTLKLTDVQKGM---- 628
G +NC+ G P +I+WYK + P +HR ++ +G+L + G
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL-PSGSLFFLRIVHGRKSRP 101
Query: 629 DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPA----SIGQLLYIPCVVSSGDM 684
DEG Y+C + + L + S + +++V L F P+ ++G+ + C G
Sbjct: 102 DEGVYVC--VARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHP 159
Query: 685 PIRITWRKDGQVIIS-GSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRE-R 742
I+W+KDG + +TI + M I+ G Y C+ +N E
Sbjct: 160 EPTISWKKDGSPLDDKDERITIRGGKLM----ITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 743 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
+L V P FV +P+N + C G P P V W+ G +Y
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY------- 268
Query: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIK 862
+I + +L IR V D+G Y C A N VG S LTV+ P P +
Sbjct: 269 --EIRDDHTLKIRKVTAGDMGSYTCVAENMVGK-AEASATLTVQEPPHFVVKPRDQVVAL 325
Query: 863 GHAKELNCTARGERPIIIRWEKGDT------VIDPDRVMRYAIATKDNGDEVVSTLKLKP 916
G C A G I W + + P R++++ GD ++ ++
Sbjct: 326 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS--QTGDLTITNVQ--- 380
Query: 917 ADRGDSVFFSCHAINSYGE--DRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRFDGN 974
R D ++ C +N G + +++T PP + R + T DG
Sbjct: 381 --RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV------IRQGPVNQTVAVDGT 432
Query: 975 SIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGR---- 1030
+++ + W + + + I L V IR GR
Sbjct: 433 FVLSCVATGSPVPTILW----RKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCI 487
Query: 1031 -SEPSKELTIST-----EEAAPDGPPM--DVTLQP----------VTSQSIQVTWKAPKK 1072
S PS E T S E P PP D L P V+ ++ ++W+
Sbjct: 488 ASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP--- 544
Query: 1073 ELQNGVI-RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 1131
L +G Y I ++ GS+ Q +K +E + LK A Y +V+A N
Sbjct: 545 NLNSGATPTSYIIEAFSHASGSSWQTVAENVK----TETSAIKGLKPNAIYLFLVRAANA 600
Query: 1132 AGTGPSSSEINATTLEDV-PSQPPENVRALSITSDVAVISWSEPPRSTLNGV-------- 1182
G S + +DV P+ + + + AV+ P + + +
Sbjct: 601 YGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQ 660
Query: 1183 ----LKGYRVIF---WSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGD 1235
++GY++++ + + + +W + T + V + + K NY ++ +
Sbjct: 661 QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQ 720
Query: 1236 GVRSSVLYIQTKEDVPG-PPAGIKAVPS--SASSVVVSWLPPTKP--NGVIRKYTIFCSS 1290
G S + + +T E+ P PP G+ + + ++++VSW PP + NG++++Y ++C
Sbjct: 721 GADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLG 780
Query: 1291 PGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIE 1343
+ + S + I L G +Y + VAA T AG G SE I+
Sbjct: 781 NETRYHINKTVDGSTFSVV--IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQ 831
Score = 131 bits (330), Expect = 6e-30
Identities = 133/477 (27%), Positives = 193/477 (40%), Gaps = 42/477 (8%)
Query: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIH-------DN 159
C A G P+ + WY G+ + H L P F +H +
Sbjct: 50 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHR----MLLPSGSLFFLRIVHGRKSRPDEG 104
Query: 160 DYFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218
Y C A N G+ S N ++ A+ R+ + D G AV +C P E
Sbjct: 105 VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE--PT 162
Query: 219 VSWEKDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
+SW+KD S + + IT GG L I+ +K DA Y C+ + GE R+S A L+
Sbjct: 163 ISWKKDG-SPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTNMV-GE-RESEVAELT 218
Query: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337
V + P+ + + V + E C A G P+P +RW KD LP +
Sbjct: 219 VLER----PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH 274
Query: 338 GLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCA 397
L I + D G+Y C N G AEA+ L V +P H + P+ +G TV C
Sbjct: 275 TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCE 334
Query: 398 LTGSPEFTIRWYRNTELVL-----PDEAISIRGLSNE-TLLITSAQKSHSGAYQCFATRK 451
TG+P+ I W R L P ++ S +S L IT+ Q+S G Y C
Sbjct: 335 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 394
Query: 452 AQTAQDFAIIALED-----GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDE 506
A + A + + D P I + V F L C A G+P PT+ W D
Sbjct: 395 AGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR-KDG 453
Query: 507 PIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR 563
+V R Q + +G + + ++ D G Y C A G A + A I V+
Sbjct: 454 VLVSTQDSRIKQ--LENGV----LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 504
Score = 102 bits (253), Expect = 5e-21
Identities = 93/324 (28%), Positives = 140/324 (43%), Gaps = 29/324 (8%)
Query: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 220
Y C N G+ S + + R + R + + A FKC + + V V
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKC---EARGDPVPTVR 255
Query: 221 WEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD 280
W KD + P+ R+ I L I V D + +Y C+ ++ + A L+V +
Sbjct: 256 WRKDDGEL-PKSRYEIRDDHTLKIRKVTAGD-MGSYTCVAENMVG---KAEASATLTVQE 310
Query: 281 PAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDG--------RPLPADSRW 332
P + D Q V G TV C A+G P PAI W ++G +P + SR+
Sbjct: 311 PPHFVVKPRD----QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 366
Query: 333 TKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVID------PLHVTLTPKKLK 385
+ TG LTI++++ D G YIC+ N GS L V D P + P
Sbjct: 367 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 426
Query: 386 TGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 445
+ T +LSC TGSP TI W ++ LV ++ I+ L N L I A+ +G Y
Sbjct: 427 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYT 485
Query: 446 CFATRKAQTAQDFAIIALED-GTP 468
C A+ + A A I +++ G P
Sbjct: 486 CIASTPSGEATWSAYIEVQEFGVP 509
Score = 69.3 bits (168), Expect = 4e-11
Identities = 76/310 (24%), Positives = 121/310 (39%), Gaps = 44/310 (14%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT-NGTLLLRAVKAEDSGYYTCTATN 1427
L C + G P P + W KD + VS R+ NG L +R K D+G YTC A+
Sbjct: 435 LSCVATGSPVPTILWRKDG----VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 490
Query: 1428 TGGFDTIIVNLLVQ---VPPDQPRLT-------------VSKTSASSITLTWIPGDNGGS 1471
G T + VQ VP PR T V+ S +++TL+W P N G+
Sbjct: 491 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 550
Query: 1472 SIRGFVLQ-YSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEII 1530
+ ++++ +S + W+ V + + + LK Y + A N+ G S+I
Sbjct: 551 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 610
Query: 1531 E-AKTHGREPSFSKDQHLFTHINSTHARLNLQG------------W--NNGGCPITAIVL 1575
+ KT P+ H +A L+L W + I +
Sbjct: 611 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 670
Query: 1576 EYRPKGT------WAWQGLRANSSGEVFLTELREATWYELRMRA-CNSAGCGNETAQFAT 1628
YRP G W +R + V + +LR+ YE++ R N + +FA
Sbjct: 671 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 730
Query: 1629 LDYDGSTIPP 1638
+ + PP
Sbjct: 731 TLEEAPSAPP 740
Score = 50.8 bits (120), Expect = 1e-05
Identities = 32/74 (43%), Positives = 36/74 (48%), Gaps = 5/74 (6%)
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
C + GDP P V+W KD D +P S R HT L +R V A D G YTC A N G
Sbjct: 244 CEARGDPVPTVRWRKD--DGELPKSRYEIRDDHT---LKIRKVTAGDMGSYTCVAENMVG 298
Query: 1431 FDTIIVNLLVQVPP 1444
L VQ PP
Sbjct: 299 KAEASATLTVQEPP 312
Score = 45.8 bits (107), Expect = 4e-04
Identities = 72/359 (20%), Positives = 127/359 (35%), Gaps = 51/359 (14%)
Query: 1294 GQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAG----KAP 1349
G+ S YE + +I + G A G+ +S +T++ K
Sbjct: 261 GELPKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 319
Query: 1350 AKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAI----PVSMDGHRLIHTN 1405
++++ G TVT C + G+P PA+ W ++ + + P +
Sbjct: 320 DQVVALGRTVT--------FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 371
Query: 1406 GTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP---PDQPRLTVSKTSASSITLT 1462
G L + V+ D GYY C N G +II ++V D+P + + +
Sbjct: 372 GDLTITNVQRSDVGYYICQTLNVAG--SIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 429
Query: 1463 WIPGDNGGSSIRGFVLQYSVDNSEEWK--DVFISSSERSFK--------LDSLKCGTWYK 1512
G+ + V S + W+ V +S+ + K + K G +
Sbjct: 430 ------DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGR 483
Query: 1513 VKLAAKNSVGSGRISEIIEAKTHG--REPSFSKDQHLF---------THINSTHARLNLQ 1561
A G S IE + G +P D +L T ++ L+ Q
Sbjct: 484 YTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 543
Query: 1562 -GWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEV-FLTELREATWYELRMRACNSAG 1618
N+G P + I+ + +WQ + N E + L+ Y +RA N+ G
Sbjct: 544 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYG 602
Score = 37.0 bits (84), Expect = 0.20
Identities = 34/157 (21%), Positives = 58/157 (36%), Gaps = 14/157 (8%)
Query: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATN-TGGFDT 1433
G P P + W KD P+ R+ G L++ + D+G Y C TN G ++
Sbjct: 157 GHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
Query: 1434 IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGF---VLQYSVDNSEEWKD 1490
+ L V P + S++ +T RG +++ D+ E K
Sbjct: 213 EVAELTVLERPSFVK------RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 1491 VFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRIS 1527
+ + + K+ + G A+N VG S
Sbjct: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS 303
Score = 34.7 bits (78), Expect = 1.0
Identities = 26/88 (29%), Positives = 37/88 (42%), Gaps = 12/88 (13%)
Query: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE----DSAIPVSMDGHRLIHT 1404
P +I+ + + L C + G P P ++W K E D P S HR++
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLP 84
Query: 1405 NGTL-LLRAVKAE----DSGYYTCTATN 1427
+G+L LR V D G Y C A N
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARN 112
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 235 bits (600), Expect = 3e-61
Identities = 239/872 (27%), Positives = 365/872 (41%), Gaps = 70/872 (8%)
Query: 90 DSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSP 149
D + +T + V + C + P + W L G+ + P +R + LQ+
Sbjct: 3626 DEPRDITVLRNRQVTLECKSDAVPPPVITW-LRNGERLQATPRVRILSGGRYLQIN---- 3680
Query: 150 SAFNSFIHDN-DYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLI 208
N+ + D +Y C A N AGK I V P ++ Q + + + K +
Sbjct: 3681 ---NADLGDTANYTCVASNIAGKTTREFILTVNV---PPNIKGGPQSLV---ILLNKSTV 3731
Query: 209 PSSVQEYVSV--VSWEKDTVSIIPEH-RFFITYHGGLYISDVQKEDALSTYRCITKHKYS 265
+ E V ++W KD + H R+ I +G L+I D Y C+ +
Sbjct: 3732 LECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDT-GRYLCMATNAAG 3790
Query: 266 GETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP 325
+ R+ + L V P P+I G + V L C A+G P P+I W K+G
Sbjct: 3791 TDRRRID---LQVHVP----PSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHL 3843
Query: 326 LPADSRWTK----RITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTP 381
L D L I +D+ TY C VTN G + T L V P + P
Sbjct: 3844 LNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEP 3903
Query: 382 KKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHS 441
+ +++C +G P +I W +N +LP R LS+ + I + Q +H+
Sbjct: 3904 TDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLP-RGDGYRILSSGAIEILATQLNHA 3962
Query: 442 GAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTW 501
G Y C A A +A + + + P I SE V L C A G P P +TW
Sbjct: 3963 GRYTCVARNAAGSAHRHVTLHVHE-PPVIQPQPSELHVILNNPILLPCEATGTPSPFITW 4021
Query: 502 ALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIR-DGGVYRCTARNLVGSAEYQARI 560
E I + S R + S G IS +R D G Y C A+N G+A + ++
Sbjct: 4022 --QKEGINVNTSGRNHAVLPSGGLQISRA------VREDAGTYMCVAQNPAGTALGKIKL 4073
Query: 561 NVRGPPSIRA-MRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTL 619
NV+ PP I ++ + ++C G P I W+KD + ++ RQ V +G+L
Sbjct: 4074 NVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSL 4133
Query: 620 KLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFE-FPPASIGQLLYIPCV 678
++ VQ G D G Y C + S S S + V VPP I+ E + +PCV
Sbjct: 4134 QIAFVQPG-DAGHYTC-MAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCV 4191
Query: 679 VSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATV 738
P I W+KD ++ + G + E L + +V L+ +G YTC+A+NAA
Sbjct: 4192 ADGIPTPA-INWKKDNVLLANLLGKY--TAEPYGELILENVVLEDSGFYTCVANNAAGED 4248
Query: 739 SRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPV 798
+ L V V P F P + G+ L+C G P PK+ W + N H
Sbjct: 4249 THTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTF---NNNIIPAHFD 4305
Query: 799 PLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMIT-SHPNT 857
+ G +S L+I V +ED G Y+C A N VG + F+ VK P + +P+
Sbjct: 4306 SVNG------HSELVIERVSKEDSGTYVCTAENSVGF-VKAIGFVYVKEPPVFKGDYPSN 4358
Query: 858 TIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGD-EVVSTLKLKP 916
I G LNC +G+ I+W + I+ + + I NG + T+
Sbjct: 4359 WIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIE----ISHRIRQLGNGSLAIYGTVN--- 4411
Query: 917 ADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
D GD ++C A N G + LT+Q PP
Sbjct: 4412 EDAGD---YTCVATNEAGVVERSMSLTLQSPP 4440
Score = 228 bits (580), Expect = 6e-59
Identities = 242/932 (25%), Positives = 382/932 (40%), Gaps = 115/932 (12%)
Query: 73 LHKARPEDVG------------TSLYFVNDSLQQVT-----FSSSVGVVV------PCPA 109
L +A PED G + YF D L T F + V VV+ C
Sbjct: 1418 LFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQV 1477
Query: 110 AGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDND-YFCTAENA 168
G+P + W+ P++ + L L N+ +D Y CT NA
Sbjct: 1478 KGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLK-------NARRNDKGRYQCTVSNA 1530
Query: 169 AGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEY--------VSVVS 220
AGK +K P +++ GNV ++ +S+ + + ++
Sbjct: 1531 AGKQAKD---IKLTIYIPPSIK-------GGNVTTDISVLINSLIKLECETRGLPMPAIT 1580
Query: 221 WEKDTVSIIPEHR-FFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVT 279
W KD I+ + +I L+I Q D+ +TY C + +G +S + V
Sbjct: 1581 WYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDS-ATYTCHVAN-VAGTAEKSFHVDVYVP 1638
Query: 280 DPAE-SIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG 338
E ++ T L+ ++V H++ L C A+G P P + WLKDG P+ A+ G
Sbjct: 1639 PMIEGNLATPLN----KQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGG 1694
Query: 339 --LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTG--------- 387
L I + D G YIC T+ G E I +D L P ++ G
Sbjct: 1695 KKLEIMSAQEIDRGQYICVATSVAGEKE---IKYEVD----VLVPPAIEGGDETSYFIVM 1747
Query: 388 IGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCF 447
+ + + L C +TGSP TI W ++ +L+ + I L+ L+I AQ S++G Y+C
Sbjct: 1748 VNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKIL-LNGRKLVIAQAQVSNTGLYRCM 1806
Query: 448 ATRKA-QTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDE 506
A A ++F + T + S SE+VV + +L C A G P P++TW DD+
Sbjct: 1807 AANTAGDHKKEFEVTVHVPPTIKS-SGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQ 1865
Query: 507 PIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPP 566
P+ + + N S G + + + D G Y C A N G + +++V PP
Sbjct: 1866 PV---NTAQGNLKIQSSGRVLQ---IAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPP 1919
Query: 567 SIR---AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTD 623
S+ M N T + + C+ G P I WYKD LL + G + +
Sbjct: 1920 SLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIE 1979
Query: 624 VQKGMDEGEYLCSVLIQP---QLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVS 680
+ D G Y C + +L S VHVA P + + + + C
Sbjct: 1980 SAQISDAGIYKCVAINSAGATELFYSLQVHVA---PSISGSNNMVAVVVNNPVRLECEAR 2036
Query: 681 SGDMPIRITWRKDGQVIISGS-GVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVS 739
P +TW KDG + S S G+ + S + L ++S + G YTC+A NAA
Sbjct: 2037 GIPAP-SLTWLKDGSPVSSFSNGLQVLSGGRI--LALTSAQISDTGRYTCVAVNAAGEKQ 2093
Query: 740 RERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVP 799
R+ L V VPP + + N + +A L C D PPP + W + HP+
Sbjct: 2094 RDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWL--------KDGHPLL 2145
Query: 800 LTGRIQILPNSSLL-IRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTT 858
+ I N S+L I +D G Y C+A+N G K+ + + +P I T
Sbjct: 2146 KKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAG-KTEKNYNVNIWVPPNIGGSDELT 2204
Query: 859 --IAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKP 916
I+G+ L C + G P + W+K + + D + R I + L++
Sbjct: 2205 QLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGR------QLQISI 2258
Query: 917 ADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
A++ D+ +SC A N G + L V P
Sbjct: 2259 AEKSDAALYSCVASNVAGTAKKEYNLQVYIRP 2290
Score = 224 bits (572), Expect = 5e-58
Identities = 227/877 (25%), Positives = 368/877 (41%), Gaps = 72/877 (8%)
Query: 90 DSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSP 149
D +++ + + C A G+P + W L G + HIR + A +++
Sbjct: 3347 DEAEKLMTLVDTSINIECRATGTPPPQINW-LKNGLPLPLSSHIRLLAAGQVIRIVRAQV 3405
Query: 150 SAFNSFIHDNDYFCTAENAAG-KIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLI 208
S Y C A N AG + N++V A ++ E+ ++G+ C+
Sbjct: 3406 SDVAV------YTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACIT 3459
Query: 209 PSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSGE 267
+ ++W +D + + ++ HG L + + ED+ Y CI ++ +GE
Sbjct: 3460 DGTP---APSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDS-GKYTCIASNE-AGE 3514
Query: 268 TRQSNGARLSVTDPAESIPTILDGFHSQE---VWAGHTVELPCTASGYPIPAIRWLKDGR 324
S L V +P ++G E V + +EL C ASG P P + W+KDGR
Sbjct: 3515 V--SKHFILKVLEPPH-----INGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGR 3567
Query: 325 PLPADSRWTKRITG--LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLT-- 380
PLP + G L IS + ED+G Y C ++ G + ++ V P ++ T
Sbjct: 3568 PLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDE 3627
Query: 381 PKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSH 440
P+ + V L C P I W RN E + + I L I +A
Sbjct: 3628 PRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILS-GGRYLQINNADLGD 3686
Query: 441 SGAYQCFATRKA-QTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTV 499
+ Y C A+ A +T ++F + + P I V+ + L C A+G P P +
Sbjct: 3687 TANYTCVASNIAGKTTREFILTV--NVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRI 3744
Query: 500 TWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQAR 559
TW D + G+H +Y++ + +++ + D G Y C A N G+ +
Sbjct: 3745 TWRKDGAVLA--GNHA--RYSILEN---GFLHIQSAHVTDTGRYLCMATNAAGTDRRRID 3797
Query: 560 INVRGPPSIR-AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFE--- 615
+ V PPSI N+T + T + C G P SI W K+ LL + Q +
Sbjct: 3798 LQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLS 3857
Query: 616 NGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLI--QPFEFPPASIGQLL 673
+G+L + D Y C+V ++V + V+VPP I +P +F +
Sbjct: 3858 SGSLVIISPSVD-DTATYECTVT-NGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAV 3915
Query: 674 YIPCVVSSGDMPIRITWRKDG-QVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIAS 732
I C S P I W K+G +++ G G I S +++I + L H G YTC+A
Sbjct: 3916 -ITCTASGVPFP-SIHWTKNGIRLLPRGDGYRILSS---GAIEILATQLNHAGRYTCVAR 3970
Query: 733 NAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNP 792
NAA + R L V PP QP+ I +L C G P P + W+
Sbjct: 3971 NAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQ-------- 4022
Query: 793 QQYHPVPLTGRIQ-ILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMI 851
++ V +GR +LP+ L I + ED G Y+C A N GT + K + L V++P +I
Sbjct: 4023 KEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGK-IKLNVQVPPVI 4081
Query: 852 TSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVST 911
+ H + L+C A G P I W K I + + + +++ +
Sbjct: 4082 SPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAI-VESIRQRVLSS--------GS 4132
Query: 912 LKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
L++ GD+ ++C A N G +LTV PP
Sbjct: 4133 LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPP 4169
Score = 221 bits (563), Expect = 6e-57
Identities = 329/1457 (22%), Positives = 549/1457 (37%), Gaps = 191/1457 (13%)
Query: 77 RPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHV 136
RP G D +++ + V +PC P + W
Sbjct: 1071 RPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW----------------- 1113
Query: 137 HANGTLQLYPFSPSAFNSFIHDND-------------YFCTAENAAGKIRSP---NIRVK 180
A T + PFSP ++F+ Y C A N AG + N+ V
Sbjct: 1114 -AKETQLISPFSPR--HTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVP 1170
Query: 181 A-VFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEY-VSVVSWEKDTVSIIPEHRFFITY 238
+ R P ++V+ + + IP + Q + V++W K +++ + ++
Sbjct: 1171 PKIQRGPKHLKVQVGQRVD---------IPCNAQGTPLPVITWSKGGSTMLVDGEHHVSN 1221
Query: 239 HGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILD-----GFH 293
G D Y C+ T + +T + PT+ D
Sbjct: 1222 PDGTLSIDQATPSDAGIYTCVA-------TNIAGTDETEITLHVQEPPTVEDLEPPYNTT 1274
Query: 294 SQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI---TGLTISDLRTEDSG 350
QE A +E PC A G P P I+WL +GR L + T L I+ + D+G
Sbjct: 1275 FQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNG 1334
Query: 351 TYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILS------CALTGSPEF 404
YIC N G+ E L V HV K + +V+L+ C + G+P
Sbjct: 1335 EYICVAVNEAGTTERKYNLKV----HVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSP 1390
Query: 405 TIRWYRNTELVLPDEAISIRGLSNETLL-ITSAQKSHSGAYQCFATRKAQTAQDFAIIAL 463
I WY++ V E+ +I+ ++N +L + A +G Y C A A T+Q + I +
Sbjct: 1391 IIMWYKDNVQVT--ESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDV 1448
Query: 464 EDGTPRIVSSFSEKV-VNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMS 522
I ++F +V V +L C KG P P + W D +P+ + +
Sbjct: 1449 LVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPN----VELL 1504
Query: 523 DGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRA---MRNITAVAG 579
D + H+ + D G Y+CT N G ++ + PPSI+ +I+ +
Sbjct: 1505 DRGQVLHLK--NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLIN 1562
Query: 580 RDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLI 639
+ C G P +I WYKD + + + + + G + D Y C V
Sbjct: 1563 SLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVA- 1621
Query: 640 QPQLSISQSVHVAVKVPPLIQPFEFPPAS----IGQLLYIPCVVSSGDMPIRITWRKDGQ 695
+ +S HV V VPP+I+ P + I L + C + PI +TW KDG
Sbjct: 1622 NVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPI-LTWLKDGV 1680
Query: 696 VIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPR---- 751
+ + + IE+ L+I S G Y C+A++ A + ++ V VPP
Sbjct: 1681 PVKANDNIRIEAGG--KKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGG 1738
Query: 752 -----FVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQI 806
F+V NN L+C V G PPP +MW + + + L GR
Sbjct: 1739 DETSYFIVMVNN-------LLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGR--- 1788
Query: 807 LPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHP-NTTIAIKGHA 865
L+I + G Y C A+N G D K +TV +P I S + + +K
Sbjct: 1789 ----KLVIAQAQVSNTGLYRCMAANTAG-DHKKEFEVTVHVPPTIKSSGLSERVVVKYKP 1843
Query: 866 KELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFF 925
L C A G I W K D P + + + +G V+ K D G +
Sbjct: 1844 VALQCIANGIPNPSITWLKDD---QPVNTAQGNLKIQSSG-RVLQIAKTLLEDAGR---Y 1896
Query: 926 SCHAINSYGEDRGLIQLTVQEPPDPPELE--IREVKARSMNLRWTQRFDGNSI--ITGF- 980
+C A N+ GE + IQL V EPP + + E S ++ + GN + IT +
Sbjct: 1897 TCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYK 1956
Query: 981 DIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMY---SFNKIGRSEPSKEL 1037
D + S S F +N+ I+D+ A + +Y + N G +E L
Sbjct: 1957 DNRLLSGSTSMTF----------LNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSL 2006
Query: 1038 TISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQY 1097
+ AP + + V + +++ +A G+ ++ SP S+
Sbjct: 2007 QV---HVAPSISGSNNMVAVVVNNPVRLECEA------RGIPAPSLTWLKDGSPVSSFSN 2057
Query: 1098 SIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENV 1157
+ ++ + G T + +Y V A N AG ++ ++ + +NV
Sbjct: 2058 GL-QVLSGGRILALTSAQISDTGRYTCV--AVNAAGEKQRDIDLRVYVPPNIMGEE-QNV 2113
Query: 1158 RALSITSDVAVISWSEP-PRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRG 1216
L I+ V ++ S+ P TL + G+ ++ E + I E +++
Sbjct: 2114 SVL-ISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKI----EDAQVQD 2168
Query: 1217 MEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVV--SWLPP 1274
++T + V T+ V +++ + + + S++ S +PP
Sbjct: 2169 TGRYTCEATNVAGKTEKNYNVN---IWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPP 2225
Query: 1275 TKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRG 1334
PN + +K + G+ + QL IA + Y + V +
Sbjct: 2226 --PNLIWKKKGSPVLTDSMGRV---RILSGGRQLQISIAEKSDAALYSCVASNVAGTAKK 2280
Query: 1335 NSSEKVTIEP----AGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDS 1390
+ +V I P +G P +II G K + L C G P P V W KD
Sbjct: 2281 EYNLQVYIRPTITNSGSHPTEIIVTRG-------KSISLECEVQGIPPPTVTWMKDGHPL 2333
Query: 1391 AIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPD----- 1445
+ G ++ L L+ + D+G Y C A N G +L V PP
Sbjct: 2334 ---IKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNH 2390
Query: 1446 QPRLTVSKTSASSITLT 1462
+ +S +S++LT
Sbjct: 2391 RSPENISVVEKNSVSLT 2407
Score = 219 bits (557), Expect = 3e-56
Identities = 227/891 (25%), Positives = 342/891 (38%), Gaps = 87/891 (9%)
Query: 89 NDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFS 148
++SL V V + C + P + WY G I + H+ + L +
Sbjct: 3063 SESLSVVNVREGTSVSLECESNAVPPPVITWY-KNGRMITESTHVEILADGQMLHIKKAE 3121
Query: 149 PSAFNSFIHDNDYFCTAENAAGKIRSP---NIRVKAVFREPYTVRVEDQRSMRGNVAVFK 205
S Y C A N AG+ N+ V P + + S +
Sbjct: 3122 VS------DTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDA 3175
Query: 206 CLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG---LYISDVQKEDALSTYRCITKH 262
IP ++W K+ I + G L I+ Q D+ Y CI +
Sbjct: 3176 TGIPPPT------IAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDS-GNYTCIASN 3228
Query: 263 KYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKD 322
E + LS+ P + S V G VEL C A+G P P I+WLKD
Sbjct: 3229 M---EGKAQKYYFLSIQVPPSVAGAEIPSDVS--VLLGENVELVCNANGIPTPLIQWLKD 3283
Query: 323 GRPLPADSRWTKRITG----LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVT 378
G+P+ + R++ L I T D+G Y C TN G + I L+V
Sbjct: 3284 GKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDR------IFNLNVY 3337
Query: 379 LTP---------KKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNE 429
+TP +KL T + +++ + C TG+P I W +N L LP + + +
Sbjct: 3338 VTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNG-LPLPLSSHIRLLAAGQ 3396
Query: 430 TLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFS--EKVVNPGEQFSL 487
+ I AQ S Y C A+ +A + + P + +S E V G S+
Sbjct: 3397 VIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVF-APPNMDNSMGTEEITVLKGSSTSM 3455
Query: 488 MCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTA 547
C G P P++ W D +P+ D + + M + + + D G Y C A
Sbjct: 3456 ACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMV-------LQLLKAETEDSGKYTCIA 3508
Query: 548 RNLVGSAEYQARINVRGPPSIRAMRN---ITAVAGRDTLINCRVIGYPYYSIKWYKDALL 604
N G + V PP I I+ + + C G P + W KD
Sbjct: 3509 SNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRP 3568
Query: 605 LPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEF 664
LP + G + + D G Y C + P + V V VPP I +
Sbjct: 3569 LPQTDQVQTLGGGEVLRISTAQVEDTGRYTC-LASSPAGDDDKEYLVRVHVPPNIAGTDE 3627
Query: 665 P---PASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSL 721
P + + + C + P+ ITW ++G+ + + V I S LQI++ L
Sbjct: 3628 PRDITVLRNRQVTLECKSDAVPPPV-ITWLRNGERLQATPRVRILSGG--RYLQINNADL 3684
Query: 722 KHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKV 781
NYTC+ASN A +RE L V VPP P + + K+ VL C +G P P++
Sbjct: 3685 GDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRI 3744
Query: 782 MWKH--AKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISK 839
W+ A +GN +Y IL N L I+ D G YLC A+N GTD +
Sbjct: 3745 TWRKDGAVLAGNHARY---------SILENGFLHIQSAHVTDTGRYLCMATNAAGTD-RR 3794
Query: 840 SMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAI 899
+ L V +P I P I L C A G I W K +++ D+
Sbjct: 3795 RIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQ------ 3848
Query: 900 ATKDNGDEVVS--TLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
N ++S +L + D+ + C N G+D+ + LTVQ PP
Sbjct: 3849 --NQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPP 3897
Score = 217 bits (552), Expect = 1e-55
Identities = 234/902 (25%), Positives = 361/902 (40%), Gaps = 83/902 (9%)
Query: 80 DVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHAN 139
DVG+ F+ + V+ V +PC G P ++W I+ P +
Sbjct: 788 DVGSPPVFIQEPAD-VSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPF----SVS 842
Query: 140 GTLQLYPFSPSAFNSFIHDND-YFCTAENAAGKIRSPN-IRVKAVFREPYTVRVEDQRSM 197
QL + N + D Y C AEN GKI+S + V + + +
Sbjct: 843 SISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVI 902
Query: 198 RGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYR 257
G C + + + W K++ ++ + G L+I VQ +D Y
Sbjct: 903 EGQQLTLPCTLLAG--NPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDG-GEYT 959
Query: 258 CITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAI 317
C+ + +G ++ + V +PTI G G V LPC ASG P P++
Sbjct: 960 CVASN-VAGTNNKTTSVVVHV------LPTIQHGQQILSTIEGIPVTLPCKASGNPKPSV 1012
Query: 318 RWLKDGRPLPADS-RWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPL 375
W K G + S +++ G L + E+SG Y+C TNT G A+ L V
Sbjct: 1013 IWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRP 1072
Query: 376 HV--------TLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRG-- 425
V P ++ G V L C + P I W + T+L+ P S R
Sbjct: 1073 RVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISP---FSPRHTF 1129
Query: 426 LSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQF 485
L + ++ IT + S SG Y C AT A A+ P+I V G++
Sbjct: 1130 LPSGSMKITETRTSDSGMYLCVATNIAGNVTQ-AVKLNVHVPPKIQRGPKHLKVQVGQRV 1188
Query: 486 SLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRC 545
+ C A+G P P +TW+ ++ DG H + DGT +++ D G+Y C
Sbjct: 1189 DIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSN---PDGT----LSIDQATPSDAGIYTC 1241
Query: 546 TARNLVGSAEYQARINVRGPPSIRAMR---NIT---AVAGRDTLINCRVIGYPYYSIKWY 599
A N+ G+ E + ++V+ PP++ + N T VA + C G P +IKW
Sbjct: 1242 VATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWL 1301
Query: 600 KDALLLPDNHRQV-VFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPL 658
+ L + + E+GTL + D GEY+C V + + + ++ V VPP+
Sbjct: 1302 HNGRELTGREPGISILEDGTLLVIASVTPYDNGEYIC-VAVNEAGTTERKYNLKVHVPPV 1360
Query: 659 IQPFE---FPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQ 715
I+ E + QL + C V PI I W KD + S TI++ L+
Sbjct: 1361 IKDKEQVTNVSVLLNQLTNLFCEVEGTPSPI-IMWYKDNVQVTESS--TIQTVNNGKILK 1417
Query: 716 ISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQ--PNNQDGIYGKAGVLNCSV 773
+ + + G Y+C A N A T + + V VPP + PN + + L C V
Sbjct: 1418 LFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQV 1477
Query: 774 DGYPPPKVMW-KHAKG--SGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQAS 830
G P P + W K K G+P V L R Q+L +++ D G Y C S
Sbjct: 1478 KGTPFPDIHWFKDGKPLFLGDPN----VELLDRGQVLH-----LKNARRNDKGRYQCTVS 1528
Query: 831 NGVGTDISKSMFLTVKIPAMITSHPNTT---IAIKGHAKELNCTARG-ERPIIIRWEKGD 886
N G +K + LT+ IP I TT + I K L C RG P I ++ G
Sbjct: 1529 NAAGKQ-AKDIKLTIYIPPSIKGGNVTTDISVLINSLIK-LECETRGLPMPAITWYKDGQ 1586
Query: 887 TVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQE 946
++ + + D G L + A DS ++CH N G + V
Sbjct: 1587 PIMSSSQALYI-----DKG----QYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYV 1637
Query: 947 PP 948
PP
Sbjct: 1638 PP 1639
Score = 214 bits (544), Expect = 9e-55
Identities = 234/888 (26%), Positives = 374/888 (42%), Gaps = 97/888 (10%)
Query: 101 VGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDND 160
+ V +PC A+G+P ++ W G+ I A+G+L Y SP S +
Sbjct: 996 IPVTLPCKASGNPKPSVIWS-KKGELISTSSAKFSAGADGSL--YVVSPGGEES----GE 1048
Query: 161 YFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRSMRGN-------VAVFKCLIPSSV 212
Y CTA N AG + +V+ V+ P DQR + + +A + +P V
Sbjct: 1049 YVCTATNTAGYAKR---KVQLTVYVRPRVFG--DQRGLSQDKPVEISVLAGEEVTLPCEV 1103
Query: 213 QEYVS-VVSWEKDTVSIIP---EHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGET 268
+ +++W K+T I P H F + G + I++ + D+ Y C+ + +G
Sbjct: 1104 KSLPPPIITWAKETQLISPFSPRHTFLPS--GSMKITETRTSDS-GMYLCVATN-IAGNV 1159
Query: 269 RQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPA 328
Q+ +L+V P P I G +V G V++PC A G P+P I W K G +
Sbjct: 1160 TQA--VKLNVHVP----PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLV 1213
Query: 329 DSRW--TKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKT 386
D + L+I D+G Y C TN G+ E L V +P V T
Sbjct: 1214 DGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNT 1273
Query: 387 GIGSTVI-----LSCALTGSPEFTIRWYRN-TELVLPDEAISIRGLSNETLL-ITSAQKS 439
V C G+P+ TI+W N EL + ISI L + TLL I S
Sbjct: 1274 TFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISI--LEDGTLLVIASVTPY 1331
Query: 440 HSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNP----GEQFSLMCAAKGAP 495
+G Y C A +A T + L+ P ++ E+V N + +L C +G P
Sbjct: 1332 DNGEYICVAVNEAGTTE--RKYNLKVHVPPVIKD-KEQVTNVSVLLNQLTNLFCEVEGTP 1388
Query: 496 PPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAE 555
P + W D+ + + + T+++G + T D G Y C A N+ G+++
Sbjct: 1389 SPIIMWYKDNVQVTESSTIQ----TVNNGKILKLFRATP---EDAGRYSCKAINIAGTSQ 1441
Query: 556 YQARINVRGPPSI---RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA--LLLPDNHR 610
I+V PP+I ++ V RD + C+V G P+ I W+KD L L D +
Sbjct: 1442 KYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNV 1501
Query: 611 QVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFP---PA 667
+++ L L + ++ D+G Y C+V ++ + + + +PP I+
Sbjct: 1502 ELLDRGQVLHLKNARRN-DKGRYQCTV-SNAAGKQAKDIKLTIYIPPSIKGGNVTTDISV 1559
Query: 668 SIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGS-GVTIESKEFMSSLQISSVSLKHNGN 726
I L+ + C MP ITW KDGQ I+S S + I+ ++ L I + +
Sbjct: 1560 LINSLIKLECETRGLPMP-AITWYKDGQPIMSSSQALYIDKGQY---LHIPRAQVSDSAT 1615
Query: 727 YTCIASNAAATVSRERQLIVRVPPRF---VVQPNNQDGIYGKAGVLNCSVDGYPPPKVMW 783
YTC +N A T + + V VPP + P N+ + + L C G P P + W
Sbjct: 1616 YTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTW 1675
Query: 784 KHAKGSGNPQQYHPVPLTGRIQI-LPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMF 842
+ PV I+I L I E D G Y+C A++ G K
Sbjct: 1676 L--------KDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIK-YE 1726
Query: 843 LTVKIPAMITSHPNTT--IAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIA 900
+ V +P I T+ I + + EL+C G P I W K +ID + +
Sbjct: 1727 VDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILL- 1785
Query: 901 TKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
NG ++V + A ++ + C A N+ G+ + ++TV PP
Sbjct: 1786 ---NGRKLV----IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPP 1826
Score = 212 bits (540), Expect = 3e-54
Identities = 234/885 (26%), Positives = 351/885 (39%), Gaps = 95/885 (10%)
Query: 103 VVVPCPAAGSPSAALRWYL-------ATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSF 155
V + C AAG+P + WY +T + I + + + A NS
Sbjct: 1938 VQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSA 1997
Query: 156 IHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEY 215
++ + A I N V V P + E RG A PS
Sbjct: 1998 GATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECE----ARGIPA------PS----- 2042
Query: 216 VSVVSWEKDTVSIIPEHRFFITYHGG--LYISDVQKEDALSTYRCITKHKYSGETRQSNG 273
++W KD + GG L ++ Q D Y C+ + +GE ++
Sbjct: 2043 ---LTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDT-GRYTCVAVNA-AGEKQRDID 2097
Query: 274 ARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPL---PADS 330
R+ V P I+ + V VEL C + P P + WLKDG PL P S
Sbjct: 2098 LRVYVP------PNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLS 2151
Query: 331 RWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGI-- 388
R L I D + +D+G Y CE TN G E + + P ++ + + + +
Sbjct: 2152 ISENRSV-LKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIE 2210
Query: 389 GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSN-ETLLITSAQKSHSGAYQCF 447
G+ + L C +G P + W + VL D +R LS L I+ A+KS + Y C
Sbjct: 2211 GNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCV 2270
Query: 448 ATRKAQTAQDFAIIALEDGTPRIVSSFS---EKVVNPGEQFSLMCAAKGAPPPTVTWALD 504
A+ A TA+ + + P I +S S E +V G+ SL C +G PPPTVTW D
Sbjct: 2271 ASNVAGTAKKEYNLQVYI-RPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKD 2329
Query: 505 DEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG 564
P+++ + +G + N+ + D G Y C A N+ G + + ++V
Sbjct: 2330 GHPLIK----AKGVEILDEGHILQLKNI---HVSDTGRYVCVAVNVAGMTDKKYDLSVHA 2382
Query: 565 PPSI----RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLK 620
PPSI R+ NI+ V + C G P SI W+KD + ++ + G +
Sbjct: 2383 PPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRML 2442
Query: 621 LTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLI---QPFEFPPASIGQLLYIPC 677
D G+Y C V+ + ++V VPP I E Q + + C
Sbjct: 2443 RLMQTTMEDAGQYTC-VVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTC 2501
Query: 678 VVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAAT 737
V+ +P ITW KDGQ + I S LQI++V + H G YTC+AS+ A
Sbjct: 2502 EVTGNPVP-EITWHKDGQPLQEDEAHHIISGG--RFLQITNVQVPHTGRYTCLASSPAGH 2558
Query: 738 VSRERQLIVRVPPRFV-----VQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNP 792
SR L V V P P + I L C YPP + W
Sbjct: 2559 KSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWF-------- 2610
Query: 793 QQYHPVPLTGRIQILPNS-SLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMI 851
+ P+ I+ILP +L I + E++ G Y C A+N G ++ K + V IP +I
Sbjct: 2611 KDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAG-EMIKHYEVKVYIPPII 2669
Query: 852 TS--------HPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKD 903
P + L C A + W K + D + A
Sbjct: 2670 NKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAA---- 2725
Query: 904 NGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
NG TL++K A D+ ++C A N GED + +Q PP
Sbjct: 2726 NG----HTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPP 2766
Score = 211 bits (538), Expect = 5e-54
Identities = 254/946 (26%), Positives = 382/946 (40%), Gaps = 95/946 (10%)
Query: 93 QQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAF 152
+++T + C G+P+ ++ W L G + H+ LQL
Sbjct: 3443 EEITVLKGSSTSMACITDGTPAPSMAW-LRDGQPLGLDAHLTVSTHGMVLQLLKAETE-- 3499
Query: 153 NSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMR---GNVAVFKCLIP 209
Y C A N AG++ S + +K V P+ E+ + N C I
Sbjct: 3500 ----DSGKYTCIASNEAGEV-SKHFILK-VLEPPHINGSEEHEEISVIVNNPLELTC-IA 3552
Query: 210 SSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG--LYISDVQKEDALSTYRCITKHKYSGE 267
S + ++W KD + P+ T GG L IS Q ED Y C+ +G+
Sbjct: 3553 SGIP--APKMTWMKDGRPL-PQTDQVQTLGGGEVLRISTAQVEDT-GRYTCLASSP-AGD 3607
Query: 268 TRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLP 327
+ R+ V P T D V V L C + P P I WL++G L
Sbjct: 3608 DDKEYLVRVHV--PPNIAGT--DEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQ 3663
Query: 328 ADSRWTKRITG---LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKL 384
A R + ++G L I++ D+ Y C +N G IL V P ++ P+ L
Sbjct: 3664 ATPR-VRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSL 3722
Query: 385 KTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAY 444
+ + +L C G P I W R VL L N L I SA + +G Y
Sbjct: 3723 VILLNKSTVLECIAEGVPTPRITW-RKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRY 3781
Query: 445 QCFATRKAQTAQDFAIIALEDGTP-RIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWAL 503
C AT A T D I L+ P I + V Q +L C A G P P++ W
Sbjct: 3782 LCMATNAAGT--DRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRK 3839
Query: 504 DDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR 563
+ + D ++ + +S G+ + + P + D Y CT N G + + V+
Sbjct: 3840 NGHLLNVD-QNQNSYRLLSSGSLV----IISPSVDDTATYECTVTNGAGDDKRTVDLTVQ 3894
Query: 564 GPPSIR-AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDAL-LLPDNHRQVVFENGTLKL 621
PPSI + +I C G P+ SI W K+ + LLP + +G +++
Sbjct: 3895 VPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEI 3954
Query: 622 TDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLL----YIPC 677
Q G Y C V S + V + V PP+IQP P+ + +L +PC
Sbjct: 3955 LATQLN-HAGRYTC-VARNAAGSAHRHVTLHVHEPPVIQP---QPSELHVILNNPILLPC 4009
Query: 678 VVSSGDMPIRITWRKDG-QVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAA 736
+ P ITW+K+G V SG + LQIS + G Y C+A N A
Sbjct: 4010 EATGTPSPF-ITWQKEGINVNTSGRNHAVLPS---GGLQISRAVREDAGTYMCVAQNPAG 4065
Query: 737 TVSRERQLIVRVPPRFVVQPNNQDGIYG--KAGVLNCSVDGYPPPKVMWKHAKGSGNPQQ 794
T + +L V+VPP V+ P+ ++ + K L+C DG PPP + W H G +
Sbjct: 4066 TALGKIKLNVQVPP--VISPHLKEYVIAVDKPITLSCEADGLPPPDITW-HKDGRAIVES 4122
Query: 795 YHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSH 854
R ++L + SL I V D G+Y C A+N G+ S S LTV +P I S
Sbjct: 4123 I-------RQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSS-STSTKLTVHVPPRIRST 4174
Query: 855 PNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKL 914
+ L C A G I W+K D V+ + + +Y + G+ ++ + L
Sbjct: 4175 EGHYTVNENSQAILPCVADGIPTPAINWKK-DNVLLANLLGKYT--AEPYGELILENVVL 4231
Query: 915 KPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPEL--EIREVKARSMNL------- 965
+ DS F++C A N+ GED + LTV P EL ++ K + L
Sbjct: 4232 E-----DSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGI 4286
Query: 966 ---RWTQRFDGNSIITGFD---------IEYKNKSDSWDFKQSTRN 999
+ T F+ N I FD IE +K DS + + N
Sbjct: 4287 PLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAEN 4332
Score = 211 bits (538), Expect = 5e-54
Identities = 233/883 (26%), Positives = 360/883 (40%), Gaps = 105/883 (11%)
Query: 93 QQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRH-VHANGTLQLYPFSPSA 151
Q + + V+ C A G P+ + W + H R+ + NG L +
Sbjct: 3720 QSLVILLNKSTVLECIAEGVPTPRITW--RKDGAVLAGNHARYSILENGFLHIQ------ 3771
Query: 152 FNSFIHDND-YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPS 210
++ + D Y C A NAAG R R+ P ++ +M V V L
Sbjct: 3772 -SAHVTDTGRYLCMATNAAGTDRR---RIDLQVHVPPSI-APGPTNMTVIVNVQTTLACE 3826
Query: 211 SVQEYVSVVSWEKD--TVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGET 268
+ ++W K+ +++ + G + D +TY C + +
Sbjct: 3827 ATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDK 3886
Query: 269 RQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDG-RPLP 327
R + L+V P P+I D V + CTASG P P+I W K+G R LP
Sbjct: 3887 RTVD---LTVQVP----PSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLP 3939
Query: 328 ADSRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKT 386
+ +G + I + +G Y C N GSA L V +P + P +L
Sbjct: 3940 RGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHV 3999
Query: 387 GIGSTVILSCALTGSPEFTIRWYR---NTELVLPDEAISIRGLSNETLLITSAQKSHSGA 443
+ + ++L C TG+P I W + N + A+ L + L I+ A + +G
Sbjct: 4000 ILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAV----LPSGGLQISRAVREDAGT 4055
Query: 444 YQCFATRKAQTAQDFAIIALEDGTPRIVSS-FSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
Y C A A TA I L P ++S E V+ + +L C A G PPP +TW
Sbjct: 4056 YMCVAQNPAGTA--LGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWH 4113
Query: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562
D IV Q +S G+ + + Q D G Y C A N+ GS+ ++ V
Sbjct: 4114 KDGRAIVES----IRQRVLSSGS----LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTV 4165
Query: 563 RGPPSIRAMR-NITAVAGRDTLINCRVIGYPYYSIKWYKDALLLP--------DNHRQVV 613
PP IR+ + T ++ C G P +I W KD +LL + + +++
Sbjct: 4166 HVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELI 4225
Query: 614 FENGTLKLTDVQKGMDEGEYLC---SVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI- 669
EN L+ D G Y C + + ++S +VHV + F P +
Sbjct: 4226 LENVVLE--------DSGFYTCVANNAAGEDTHTVSLTVHV-------LPTFTELPGDVS 4270
Query: 670 ---GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGN 726
G+ L + C + +P ++TW + +I + +S S L I VS + +G
Sbjct: 4271 LNKGEQLRLSCKATGIPLP-KLTWTFNNNIIPAH----FDSVNGHSELVIERVSKEDSGT 4325
Query: 727 YTCIASNAAATVSRERQLIVRVPPRFVVQ-PNNQDGIYGKAGVLNCSVDGYPPPKVMWKH 785
Y C A N+ V + V+ PP F P+N G +LNC V G P P + W
Sbjct: 4326 YVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNR 4385
Query: 786 AKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTV 845
KG + ++ RI+ L N SL I + ED G Y C A+N G + +SM LT+
Sbjct: 4386 -KGVD-------IEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGV-VERSMSLTL 4436
Query: 846 KIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEK-GDTVIDPDRVMRYAIATKDN 904
+ P +IT P T+ G LNC A GE I W + G ++ DRV
Sbjct: 4437 QSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRV---------- 4486
Query: 905 GDEVVS--TLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQ 945
V+S +L + A + D+ F C A N G + + VQ
Sbjct: 4487 --NVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQ 4527
Score = 207 bits (526), Expect = 1e-52
Identities = 211/811 (26%), Positives = 345/811 (42%), Gaps = 56/811 (6%)
Query: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMR-GNVAVFKCLIPSSVQEYVSVV 219
Y C A ++AG R+ V P ++V + ++ G AV CLI S+V ++
Sbjct: 497 YECIAVSSAGTGRAQTFF--DVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQ 554
Query: 220 SWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVT 279
++D V + R + L + V+ DA Y C+ + G + S L+V
Sbjct: 555 RNDRD-VRLAEPARIRTLANLSLELKSVKFNDA-GEYHCMVSSE-GGSSAAS--VFLTVQ 609
Query: 280 DPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG- 338
+P P + +Q G V + C+A+GYP P I W + + R+ G
Sbjct: 610 EP----PKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGT 665
Query: 339 LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCAL 398
L I + +D+G Y C +N+ G+ + L I+ + + +L +G ++ C
Sbjct: 666 LFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKT 725
Query: 399 TGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDF 458
+G P ++W++ + P + I L L I Q +G Y C A +A A
Sbjct: 726 SGIPPPQVKWFKGDLELRPSTFLIIDPLLG-LLKIQETQDLDAGDYTCVAINEAGRAT-- 782
Query: 459 AIIALEDGTPRI-VSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA-LDDEPIVRDGSHRT 516
I L+ G+P + + ++ + G +L C +G P PT+ W LD+ PI +
Sbjct: 783 GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVS 842
Query: 517 NQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG--PPSIRAMRNI 574
+ + G + D G Y C A N G + + + V G P I ++
Sbjct: 843 SISQLRTGALF----ILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSV 898
Query: 575 T-AVAGRDTLINCRVI-GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632
+ G+ + C ++ G P +W K++ +L N V +G+L + VQ D GE
Sbjct: 899 ANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQL-QDGGE 957
Query: 633 YLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI-GQLLYIPCVVSSGDMPIRITWR 691
Y C V + +++ V V V P IQ + ++I G + +PC S P + W
Sbjct: 958 YTC-VASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKP-SVIWS 1015
Query: 692 KDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPR 751
K G++I + S + SL + S + +G Y C A+N A R+ QL V V PR
Sbjct: 1016 KKGELISTSSAKFSAGAD--GSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPR 1073
Query: 752 FVV--------QPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGR 803
+P + G+ L C V PPP + W AK + + P R
Sbjct: 1074 VFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW--AKETQLISPFSP-----R 1126
Query: 804 IQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKG 863
LP+ S+ I D G YLC A+N G ++++++ L V +P I P G
Sbjct: 1127 HTFLPSGSMKITETRTSDSGMYLCVATNIAG-NVTQAVKLNVHVPPKIQRGPKHLKVQVG 1185
Query: 864 HAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSV 923
++ C A+G +I W KG + + D + ++ D TL + A D+
Sbjct: 1186 QRVDIPCNAQGTPLPVITWSKGGSTMLVDG--EHHVSNPDG------TLSIDQATPSDAG 1237
Query: 924 FFSCHAINSYGEDRGLIQLTVQEPPDPPELE 954
++C A N G D I L VQEPP +LE
Sbjct: 1238 IYTCVATNIAGTDETEITLHVQEPPTVEDLE 1268
Score = 201 bits (512), Expect = 5e-51
Identities = 225/898 (25%), Positives = 352/898 (39%), Gaps = 80/898 (8%)
Query: 90 DSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSP 149
++L+ V V + C G+P + W+ G + + H+ + G F
Sbjct: 2484 NTLEDVKVKEKQSVTLTCEVTGNPVPEITWH-KDGQPLQE-DEAHHIISGGR-----FLQ 2536
Query: 150 SAFNSFIHDNDYFCTAENAAG-KIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFK--- 205
H Y C A + AG K RS ++ VF P V + +
Sbjct: 2537 ITNVQVPHTGRYTCLASSPAGHKSRSFSLN---VFVSPTIAGVGSDGNPEDVTVILNSPT 2593
Query: 206 CLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHG-GLYISDVQKEDALSTYRCITKHKY 264
L+ + + ++W KD + I G L I + Q ED Y C+ ++
Sbjct: 2594 SLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQ-EDNAGRYSCVATNE- 2651
Query: 265 SGETRQSNGARLSVTDPAESIPTILDGFHSQEV--WAGHTVELPCTASGYPIPAIRWLKD 322
+GE + ++ + G +EV +T+ L C A P ++ W KD
Sbjct: 2652 AGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKD 2711
Query: 323 GRPLPADSRWTKRITG--LTISDLRTEDSGTYICEVTNTFGSAEAT-GILMVIDPLHVTL 379
G+PL +D G L I + + D+G Y C +N G E + + + P L
Sbjct: 2712 GQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKL 2771
Query: 380 --TPKKLKTG---------IGSTVILSCALTGSPEFTIRWYRNTE-LVLPDEAISIRGLS 427
L TG I + + L C +P T+ WY++ L D+ + + G
Sbjct: 2772 WEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPG-- 2829
Query: 428 NETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFS-----EKVVNPG 482
L I A+ +G Y C A +A +D + P I+ + E V
Sbjct: 2830 GRVLQIPRAKVEDAGRYTCVAVNEA--GEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVN 2887
Query: 483 EQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGV 542
+ + C + G+P P +W D +P++ D H+ +S+G + +N QI D G
Sbjct: 2888 KSALIECLSSGSPAPRNSWQKDGQPLLEDDHHK----FLSNGRILQILNT---QITDIGR 2940
Query: 543 YRCTARNLVGSAEYQARINVRGPPSIRAMR--NITAVAGRDTLINCRVIGYPYYSIKWYK 600
Y C A N GSA+ +NV PPS+ + N+T V + C V G+P + W K
Sbjct: 2941 YVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLK 3000
Query: 601 DALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQ 660
+ + N ++ G K D GEY C + Q S + + V VPP I+
Sbjct: 3001 NEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGES-KKKFSLTVYVPPSIK 3059
Query: 661 PFEFPPASI-----GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQ 715
+ S+ G + + C ++ P+ ITW K+G++I + V I + M L
Sbjct: 3060 DHDSESLSVVNVREGTSVSLECESNAVPPPV-ITWYKNGRMITESTHVEILADGQM--LH 3116
Query: 716 ISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGI--YGKAGVLNCSV 773
I + G Y C A N A + L V VPP + P + + L C
Sbjct: 3117 IKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPS-IEGPEREVIVETISNPVTLTCDA 3175
Query: 774 DGYPPPKVMW-KHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNG 832
G PPP + W K+ K N L+G S L I D G Y C ASN
Sbjct: 3176 TGIPPPTIAWLKNHKRIENSDSLEVRILSG------GSKLQIARSQHSDSGNYTCIASNM 3229
Query: 833 VGTDISKSMFLTVKIPAMITSH--PNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVID 890
G K FL++++P + P+ + G EL C A G +I+W K I
Sbjct: 3230 EG-KAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIA 3288
Query: 891 PDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
R ++ NG STL + A D+ ++C A N GE+ + L V P
Sbjct: 3289 SGETERIRVSA--NG----STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTP 3340
Score = 197 bits (502), Expect = 7e-50
Identities = 312/1442 (21%), Positives = 540/1442 (37%), Gaps = 172/1442 (11%)
Query: 93 QQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAF 152
Q V+ S V + C + P L W L G + P + L++
Sbjct: 2111 QNVSVLISQAVELLCQSDAIPPPTLTW-LKDGHPLLKKPGLSISENRSVLKIE------- 2162
Query: 153 NSFIHDND-YFCTAENAAGKI-RSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPS 210
++ + D Y C A N AGK ++ N+ + + + + GN+ C S
Sbjct: 2163 DAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLC--ES 2220
Query: 211 SVQEYVSVVSWEKDTVSIIPEHRFFITYHGG---LYISDVQKEDALSTYRCITKHKYSGE 267
S +++ W+K ++ + + G L IS +K DA + Y C+ + +G
Sbjct: 2221 SGIPPPNLI-WKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDA-ALYSCVASN-VAGT 2277
Query: 268 TRQSNGARLSVTDPAESIPTILD-GFHSQE--VWAGHTVELPCTASGYPIPAIRWLKDGR 324
++ ++ + PTI + G H E V G ++ L C G P P + W+KDG
Sbjct: 2278 AKKEYNLQVYIR------PTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGH 2331
Query: 325 PLPADSRWTKRITG--LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVT---L 379
PL G L + ++ D+G Y+C N G + L V P +
Sbjct: 2332 PLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHR 2391
Query: 380 TPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKS 439
+P+ + ++V L+C +G P +I W+++ V ++ I L +
Sbjct: 2392 SPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILS-GGRMLRLMQTTME 2450
Query: 440 HSGAYQCFATRKA-QTAQDFAIIALEDGTPRIV--SSFSEKVVNPGEQFSLMCAAKGAPP 496
+G Y C A + + F + L P IV ++ + V + +L C G P
Sbjct: 2451 DAGQYTCVVRNAAGEERKIFGLSVLVP--PHIVGENTLEDVKVKEKQSVTLTCEVTGNPV 2508
Query: 497 PTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEY 556
P +TW D +P+ D +H + +S G + +T Q+ G Y C A + G
Sbjct: 2509 PEITWHKDGQPLQEDEAH----HIISGGR---FLQITNVQVPHTGRYTCLASSPAGHKSR 2561
Query: 557 QARINVRGPPSIRAM------RNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHR 610
+NV P+I + ++T + T + C YP +I W+KD L N
Sbjct: 2562 SFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRN 2621
Query: 611 QVVFENG-TLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEF--PPA 667
+ G TL++ + Q+ + G Y C V + + V V +PP+I + P
Sbjct: 2622 IRILPGGRTLQILNAQED-NAGRYSC-VATNEAGEMIKHYEVKVYIPPIINKGDLWGPGL 2679
Query: 668 S-------IGQLLYIPCVVSSGDMP-IRITWRKDGQVIISGSGVTIESKEFMSSLQISSV 719
S + L + C + +P ++W KDGQ + S V I + +LQI
Sbjct: 2680 SPKEVKIKVNNTLTLECEAYA--IPSASLSWYKDGQPLKSDDHVNIAANGH--TLQIKEA 2735
Query: 720 SLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVV------------QPNNQDGIYGKAG 767
+ G YTC+ASN A + + ++VPP F +D I
Sbjct: 2736 QISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 768 VLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLL-IRHVLEEDIGYYL 826
L C + PPP + W + HP+ + ++ ILP +L I ED G Y
Sbjct: 2796 SLYCETNAAPPPTLTWY--------KDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYT 2847
Query: 827 CQASNGVGTDISKSMFLTVKIPAMI----TSHPNTTIAIKGHAKELNCTARGERPIIIRW 882
C A N G D S + V +P +I + P + + + C + G W
Sbjct: 2848 CVAVNEAGED-SLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSW 2906
Query: 883 EKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQL 942
+K + D ++ NG ++ L + D G V C A N+ G + L
Sbjct: 2907 QKDGQPLLEDDHHKFL----SNG-RILQILNTQITDIGRYV---CVAENTAGSAKKYFNL 2958
Query: 943 TVQEPPDPPELEIREVKARSMNLRWTQRFDGNSIITGF---DIEYKNKSDSWDFKQSTRN 999
V PP + K+ ++ + ++GF D+ + +T
Sbjct: 2959 NVHVPPS-----VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTL- 3012
Query: 1000 ISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVT 1059
I P I+ + + N+ G S+ LT+ + D +++ V
Sbjct: 3013 IVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVR 3072
Query: 1060 SQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKF 1119
+ V+ + + VI Y+ G + + VE+ A G +
Sbjct: 3073 -EGTSVSLECESNAVPPPVITWYKNGRMIT------ESTHVEILADGQMLHIKKAEVSDT 3125
Query: 1120 AQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENV-----RALSITSDVA-----VI 1169
QY V +A N AG + +N + E + +++T D I
Sbjct: 3126 GQY--VCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTI 3183
Query: 1170 SWSEPPRSTLNGVLKGYRVIFWSLYVD---GEWGEMQNITTTRERVELRGMEKFTNYSVQ 1226
+W + + N R++ + + + N T +E + +K+ S+Q
Sbjct: 3184 AWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKA-QKYYFLSIQ 3242
Query: 1227 VLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTI 1286
V + AG + S V + G + + + ++ WL KP I
Sbjct: 3243 VPP-SVAGAEIPSDVSVLL------GENVELVCNANGIPTPLIQWLKDGKPIASGETERI 3295
Query: 1287 FCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWV--AAVTSAGRGNSSEKVTIEP 1344
S+ GS TS + +A G++ ++ VT RGN E
Sbjct: 3296 RVSANGSTLNIYGAL-TSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEA----- 3349
Query: 1345 AGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH-RLIH 1403
K+++ T + + C + G P P + W K+ +P+ + H RL+
Sbjct: 3350 -----EKLMTLVDT-------SINIECRATGTPPPQINWLKNG----LPLPLSSHIRLLA 3393
Query: 1404 TNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQ------PRLTVSKTSAS 1457
+ + + D YTC A+N G D NL V PP+ +TV K S++
Sbjct: 3394 AGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSST 3453
Query: 1458 SI 1459
S+
Sbjct: 3454 SM 3455
Score = 192 bits (487), Expect = 4e-48
Identities = 224/912 (24%), Positives = 358/912 (39%), Gaps = 98/912 (10%)
Query: 91 SLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPS 150
S + ++ V + C A+G P ++ W+ G + +R + L+L
Sbjct: 2392 SPENISVVEKNSVSLTCEASGIPLPSITWF-KDGWPVSLSNSVRILSGGRMLRLMQ---- 2446
Query: 151 AFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTV---RVEDQRSMRGNVAVFKCL 207
+ Y C NAAG+ R I +V P+ V +ED + C
Sbjct: 2447 --TTMEDAGQYTCVVRNAAGEERK--IFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCE 2502
Query: 208 IPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSG 266
+ + V ++W KD + + I G L I++VQ Y C+ +G
Sbjct: 2503 VTGNP---VPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHT-GRYTCLASSP-AG 2557
Query: 267 ETRQSNGARLSVTDPAESIPTILDGFHSQ-EVWAGHTVELPCTASGYPIPAIRWLKDGRP 325
+S + V+ + + DG V L C A YP I W KDG P
Sbjct: 2558 HKSRSFSLNVFVSPTIAGVGS--DGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTP 2615
Query: 326 LPADSRWTKRITGLTISDLRTED--SGTYICEVTNTFGSAEATGILMVIDPLHVT----- 378
L ++ G T+ L ++ +G Y C TN G + V P +
Sbjct: 2616 LESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLW 2675
Query: 379 ---LTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITS 435
L+PK++K + +T+ L C P ++ WY++ + + D+ ++I + TL I
Sbjct: 2676 GPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAA-NGHTLQIKE 2734
Query: 436 AQKSHSGAYQCFATRKA-QTAQDFAIIALEDGTPRIVSSFSE----------------KV 478
AQ S +G Y C A+ A + DF D ++ SF + K
Sbjct: 2735 AQISDTGRYTCVASNIAGEDELDF------DVNIQVPPSFQKLWEIGNMLDTGRNGEAKD 2788
Query: 479 VNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIR 538
V SL C APPPT+TW D P+ +++ + G + + + ++
Sbjct: 2789 VIINNPISLYCETNAAPPPTLTWYKDGHPLTS-----SDKVLILPGGRV--LQIPRAKVE 2841
Query: 539 DGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRN-----ITAVAGRDTLINCRVIGYPY 593
D G Y C A N G Q + V PP I+ + +T + + LI C G P
Sbjct: 2842 DAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPA 2901
Query: 594 YSIKWYKDAL-LLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVA 652
W KD LL D+H + + L++ + Q D G Y+C V S + ++
Sbjct: 2902 PRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQI-TDIGRYVC-VAENTAGSAKKYFNLN 2959
Query: 653 VKVPPLI--QPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEF 710
V VPP + E + + + C VS G P ++W K+ Q I + I
Sbjct: 2960 VHVPPSVIGPKSENLTVVVNNFISLTCEVS-GFPPPDLSWLKNEQPIKLNTNTLIVPGG- 3017
Query: 711 MSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIY----GKA 766
+LQI + G YTCIA N A ++ L V VPP + + G +
Sbjct: 3018 -RTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTS 3076
Query: 767 GVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLL-IRHVLEEDIGYY 825
L C + PPP + W + G + H ++IL + +L I+ D G Y
Sbjct: 3077 VSLECESNAVPPPVITW-YKNGRMITESTH-------VEILADGQMLHIKKAEVSDTGQY 3128
Query: 826 LCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIK--GHAKELNCTARGERPIIIRWE 883
+C+A N G D K+ L V +P I P + ++ + L C A G P I W
Sbjct: 3129 VCRAINVAGRD-DKNFHLNVYVPPSIEG-PEREVIVETISNPVTLTCDATGIPPPTIAWL 3186
Query: 884 KGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLT 943
K I+ + I + S L++ + DS ++C A N G+ + L+
Sbjct: 3187 KNHKRIENSDSLEVRILSGG------SKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLS 3240
Query: 944 VQEPPDPPELEI 955
+Q PP EI
Sbjct: 3241 IQVPPSVAGAEI 3252
Score = 186 bits (473), Expect = 2e-46
Identities = 301/1362 (22%), Positives = 516/1362 (37%), Gaps = 206/1362 (15%)
Query: 161 YFCTAENAAGKIR---SPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVS 217
Y C A N AG+ + V + + + E+ + A+ +CL S S
Sbjct: 2846 YTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNS 2905
Query: 218 VVSWEKDTVSIIPE-HRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSN---G 273
W+KD ++ + H F++ L I + Q D + Y C+ ++ + N
Sbjct: 2906 ---WQKDGQPLLEDDHHKFLSNGRILQILNTQITD-IGRYVCVAENTAGSAKKYFNLNVH 2961
Query: 274 ARLSVTDP-AESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRW 332
SV P +E++ +++ F + L C SG+P P + WLK+ +P+ ++
Sbjct: 2962 VPPSVIGPKSENLTVVVNNF----------ISLTCEVSGFPPPDLSWLKNEQPIKLNTNT 3011
Query: 333 TKRITGLTISDLRTE--DSGTYICEVTNTFGSAEATGILMVIDPL----HVTLTPKKLKT 386
G T+ +R + D G Y C N G ++ L V P H + + +
Sbjct: 3012 LIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNV 3071
Query: 387 GIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQC 446
G++V L C P I WY+N ++ + I + L I A+ S +G Y C
Sbjct: 3072 REGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILA-DGQMLHIKKAEVSDTGQYVC 3130
Query: 447 FATRKAQTAQDFAIIALEDGTPRIVSSFSEKVV-----NPGEQFSLMCAAKGAPPPTVTW 501
A A +D L P + +V+ NP +L C A G PPPT+ W
Sbjct: 3131 RAINVA--GRDDKNFHLNVYVPPSIEGPEREVIVETISNP---VTLTCDATGIPPPTIAW 3185
Query: 502 ALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARIN 561
+ + I + S +S G S + + Q D G Y C A N+ G A+ ++
Sbjct: 3186 LKNHKRI--ENSDSLEVRILSGG---SKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLS 3240
Query: 562 VRGPPSIRAMR---NITAVAGRDTLINCRVIGYPYYSIKWYKDA--LLLPDNHRQVVFEN 616
++ PPS+ +++ + G + + C G P I+W KD + + R V N
Sbjct: 3241 IQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSAN 3300
Query: 617 GTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQL---- 672
G+ D G+Y C V P + ++ V V P I+ + + L
Sbjct: 3301 GSTLNIYGALTSDTGKYTC-VATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTS 3359
Query: 673 LYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSL---QISSVSLKHNGNYTC 729
+ I C ++G P +I W K+G + S + + + + + Q+S V++ YTC
Sbjct: 3360 INIECR-ATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAV-----YTC 3413
Query: 730 IASNAAATVSRERQLIVRVPPRFVVQPNNQD--GIYGKAGVLNCSVDGYPPPKVMWKHAK 787
+ASN A ++ L V PP ++ + G + + C DG P P + W
Sbjct: 3414 VASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWL--- 3470
Query: 788 GSGNPQQYHPVPLTGRIQILPNSSLL-IRHVLEEDIGYYLCQASNGVGTDISKSMFLTVK 846
+ P+ L + + + +L + ED G Y C ASN G ++SK L V
Sbjct: 3471 -----RDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAG-EVSKHFILKVL 3524
Query: 847 IPAMITS---HPNTTIAIKGHAKELNCTARGERPIIIRWEK-GDTVIDPDRVMRYAIATK 902
P I H ++ + + EL C A G + W K G + D+V
Sbjct: 3525 EPPHINGSEEHEEISVIVN-NPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLG---- 3579
Query: 903 DNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARS 962
G EV L++ A D+ ++C A + G+D + V PP
Sbjct: 3580 --GGEV---LRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPP-------------- 3620
Query: 963 MNLRWTQRFDGNSIITGFDIEYKNKSDS-------WDFKQSTRNISPTIN--------QA 1007
N+ T +++ + + KSD+ W +P + Q
Sbjct: 3621 -NIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQI 3679
Query: 1008 NIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTS------- 1060
N DL + Y+ + N G++ LT++ GP V L ++
Sbjct: 3680 NNADLGDTANYTC--VASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAE 3737
Query: 1061 --QSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKK 1118
+ ++TW+ ++G + G++ +YSI+E + D +
Sbjct: 3738 GVPTPRITWR------KDGAVLA----------GNHARYSILENGFLHIQSAHVTDTGR- 3780
Query: 1119 FAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRST 1178
+ A N AGT ++ + P +++ + +A + + P+ +
Sbjct: 3781 -----YLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEA-TGIPKPS 3834
Query: 1179 LNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVR 1238
+N G+ L VD + +++ + ++ Y V AGD R
Sbjct: 3835 INWRKNGHL-----LNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVT--NGAGDDKR 3887
Query: 1239 SSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAP 1298
+ L +Q + P V A +V+ C++ SG P P
Sbjct: 3888 TVDLTVQVPPSIADEPTDF-LVTKHAPAVIT------------------CTA--SGVPFP 3926
Query: 1299 SEYETS------PEQLFYRI----------AHLNRGQQYLLWVAAVTSAGRGNSSEKVTI 1342
S + T P YRI LN +Y V G++ VT+
Sbjct: 3927 SIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRY----TCVARNAAGSAHRHVTL 3982
Query: 1343 EPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLI 1402
P I + + LPC + G P+P + W K+ + + S H ++
Sbjct: 3983 HV--HEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGIN--VNTSGRNHAVL 4038
Query: 1403 HTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP 1444
+ G + RAV+ ED+G Y C A N G + L VQVPP
Sbjct: 4039 PSGGLQISRAVR-EDAGTYMCVAQNPAGTALGKIKLNVQVPP 4079
Score = 181 bits (458), Expect = 9e-45
Identities = 193/778 (24%), Positives = 323/778 (41%), Gaps = 79/778 (10%)
Query: 95 VTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVH---ANGTLQLYPFSPSA 151
+T +V + C A G P ++ W + +V ++ + ++G+L + SPS
Sbjct: 3813 MTVIVNVQTTLACEATGIPKPSINW--RKNGHLLNVDQNQNSYRLLSSGSLVI--ISPSV 3868
Query: 152 FNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVE--DQRSMRGNVAVFKCLIP 209
++ ++ CT N AG + V + P ++ E D + AV C
Sbjct: 3869 DDTATYE----CTVTNGAGDDKRT---VDLTVQVPPSIADEPTDFLVTKHAPAVITCT-- 3919
Query: 210 SSVQEYVSVVSWEKDTVSIIPE-HRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGET 268
+S + S+ W K+ + ++P + I G + I Q A Y C+ ++
Sbjct: 3920 ASGVPFPSI-HWTKNGIRLLPRGDGYRILSSGAIEILATQLNHA-GRYTCVARNAAGSAH 3977
Query: 269 RQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPA 328
R L V +P P I V + + LPC A+G P P I W K+G +
Sbjct: 3978 RH---VTLHVHEP----PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNT 4030
Query: 329 DSRWTKRIT--GLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKT 386
R + GL IS ED+GTY+C N G+A L V P ++ K+
Sbjct: 4031 SGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVI 4090
Query: 387 GIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQC 446
+ + LSC G P I W+++ ++ E+I R LS+ +L I Q +G Y C
Sbjct: 4091 AVDKPITLSCEADGLPPPDITWHKDGRAIV--ESIRQRVLSSGSLQIAFVQPGDAGHYTC 4148
Query: 447 FATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDE 506
A A ++ + + PRI S+ VN Q L C A G P P + W D+
Sbjct: 4149 MAANVAGSSSTSTKLTVHV-PPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNV 4207
Query: 507 PIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPP 566
+ ++ +YT + NV + D G Y C A N G + + V P
Sbjct: 4208 LL----ANLLGKYTAEPYGELILENVV---LEDSGFYTCVANNAAGEDTHTVSLTVHVLP 4260
Query: 567 SIRAMR-NITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQ 625
+ + +++ G ++C+ G P + W + ++P H V + L + V
Sbjct: 4261 TFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA-HFDSVNGHSELVIERVS 4319
Query: 626 KGMDEGEYLCSVLIQPQLSISQSV-HVAVKVPPLIQPFEFPP---ASIGQLLYIPCVVSS 681
K D G Y+C+ + + +++ V VK PP+ + ++P +G + C V
Sbjct: 4320 KE-DSGTYVCTA--ENSVGFVKAIGFVYVKEPPVFKG-DYPSNWIEPLGGNAILNCEVK- 4374
Query: 682 GDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSL-----KHNGNYTCIASNAAA 736
GD I W + GV IE + L S+++ + G+YTC+A+N A
Sbjct: 4375 GDPTPTIQWNR--------KGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAG 4426
Query: 737 TVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYH 796
V R L ++ PP ++P G +LNC G P P + W +Q H
Sbjct: 4427 VVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWS--------RQGH 4478
Query: 797 PVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSH 854
+ R+ +L N+SL I +ED + C A N +G+ + V++P ++ H
Sbjct: 4479 SISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGS-------VLVRVPVIVQVH 4529
Score = 167 bits (424), Expect = 8e-41
Identities = 173/655 (26%), Positives = 279/655 (42%), Gaps = 40/655 (6%)
Query: 304 ELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT-GLTISDLRTEDSGTYICEVTNTFGS 362
++PC+ + ++++G L D + + L I+ + D G Y C ++ G+
Sbjct: 448 QIPCSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGT 507
Query: 363 AEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAIS 422
A V +P V P + G +L+C + + ++ + W RN V E
Sbjct: 508 GRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPAR 567
Query: 423 IRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPG 482
IR L+N +L + S + + +G Y C + + ++ + +++ P++ + G
Sbjct: 568 IRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQE-PPKVTVMPKNQSFTGG 626
Query: 483 EQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTM-SDGTTISHMNVTGPQIRDGG 541
+ S+MC+A G P P + W ++D IV GSHR Y M SDGT + + +D G
Sbjct: 627 SEVSIMCSATGYPKPKIAWTVNDMFIV--GSHR---YRMTSDGT----LFIKNAAPKDAG 677
Query: 542 VYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVA-GRDTLINCRVIGYPYYSIKWYK 600
+Y C A N G+ + + + P + +++ VA G T++ C+ G P +KW+K
Sbjct: 678 IYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFK 737
Query: 601 -DALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPL- 658
D L P + G LK+ + Q +D G+Y C V I + + + V PP+
Sbjct: 738 GDLELRPSTFLIIDPLLGLLKIQETQ-DLDAGDYTC-VAINEAGRATGKITLDVGSPPVF 795
Query: 659 IQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRK-DGQVIISGS-GVTIESKEFMSSLQI 716
IQ IG + +PC V P I WR+ D I S V+ S+ +L I
Sbjct: 796 IQEPADVSMEIGSNVTLPCYVQGYPEP-TIKWRRLDNMPIFSRPFSVSSISQLRTGALFI 854
Query: 717 SSVSLKHNGNYTCIASNAAATVSRERQLIVR--VPPRFVVQPNNQDGIYGKAGVLNCS-V 773
++ G Y C A N + E + V V P + P+ + I G+ L C+ +
Sbjct: 855 LNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLL 914
Query: 774 DGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGV 833
G P P+ W K S Q I + + SL I V +D G Y C ASN
Sbjct: 915 AGNPIPERRW--IKNSAMLLQ------NPYITVRSDGSLHIERVQLQDGGEYTCVASNVA 966
Query: 834 GTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDR 893
GT+ +K+ + V + I I+G L C A G + W K +I
Sbjct: 967 GTN-NKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSS 1025
Query: 894 VMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
A A D VVS P +S + C A N+ G + +QLTV P
Sbjct: 1026 AKFSAGA--DGSLYVVS-----PGGE-ESGEYVCTATNTAGYAKRKVQLTVYVRP 1072
Score = 70.5 bits (171), Expect = 2e-11
Identities = 54/172 (31%), Positives = 73/172 (42%), Gaps = 21/172 (12%)
Query: 1311 RIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLP 1370
+IA + G A AG ++S K+T+ P +I S G T LP
Sbjct: 4134 QIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVH----VPPRIRSTEGHYTVNENSQAILP 4189
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
C + G P PA+ W KD+ + ++ G G L+L V EDSG+YTC A N G
Sbjct: 4190 CVADGIPTPAINWKKDN---VLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAG 4246
Query: 1431 FDTIIVNLLVQVPP--------------DQPRLTVSKTSASSITLTWIPGDN 1468
DT V+L V V P +Q RL+ T LTW +N
Sbjct: 4247 EDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNN 4298
Score = 59.7 bits (143), Expect = 3e-08
Identities = 44/160 (27%), Positives = 73/160 (45%), Gaps = 13/160 (8%)
Query: 1308 LFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPA-GKAPAKIISFGGTVTTPWMKD 1366
L + AH+ +YL R +V + P+ P + TT
Sbjct: 3768 LHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTT----- 3822
Query: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTAT 1426
L C + G P P++ W K+ + + + +RL+ ++G+L++ + +D+ Y CT T
Sbjct: 3823 --LACEATGIPKPSINWRKNGHLLNVDQNQNSYRLL-SSGSLVIISPSVDDTATYECTVT 3879
Query: 1427 NTGGFDTIIVNLLVQVPP---DQPR-LTVSKTSASSITLT 1462
N G D V+L VQVPP D+P V+K + + IT T
Sbjct: 3880 NGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCT 3919
Score = 52.4 bits (124), Expect = 5e-06
Identities = 35/115 (30%), Positives = 55/115 (47%), Gaps = 9/115 (7%)
Query: 1357 GTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAE 1416
G V+ + +RL C + G P P + WT ++ + IP D ++ + L++ V E
Sbjct: 4267 GDVSLNKGEQLRLSCKATGIPLPKLTWTFNN--NIIPAHFDS---VNGHSELVIERVSKE 4321
Query: 1417 DSGYYTCTATNTGGFDTIIVNLLVQVPP----DQPRLTVSKTSASSITLTWIPGD 1467
DSG Y CTA N+ GF I + V+ PP D P + ++I + GD
Sbjct: 4322 DSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGD 4376
Score = 51.2 bits (121), Expect = 1e-05
Identities = 34/97 (35%), Positives = 48/97 (49%), Gaps = 7/97 (7%)
Query: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTAT 1426
V LPC + G+P P+V W+K E + + +G+L + + E+SG Y CTAT
Sbjct: 998 VTLPCKASGNPKPSVIWSKKGE---LISTSSAKFSAGADGSLYVVSPGGEESGEYVCTAT 1054
Query: 1427 NTGGFDTIIVNLLVQVPP----DQPRLTVSKTSASSI 1459
NT G+ V L V V P DQ L+ K S+
Sbjct: 1055 NTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISV 1091
Score = 50.8 bits (120), Expect = 1e-05
Identities = 48/175 (27%), Positives = 71/175 (40%), Gaps = 34/175 (19%)
Query: 1359 VTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLL-LRAVKAED 1417
VT K + C S G PAP W KD + P+ D H +NG +L + + D
Sbjct: 2882 VTVLVNKSALIECLSSGSPAPRNSWQKDGQ----PLLEDDHHKFLSNGRILQILNTQITD 2937
Query: 1418 SGYYTCTATNTGGFDTIIVNLLVQVPPD-----QPRLTVSKTSASSIT----------LT 1462
G Y C A NT G NL V VPP LTV + S+T L+
Sbjct: 2938 IGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLS 2997
Query: 1463 WIPGDN------------GGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSL 1505
W+ + GG +++ +++ V + E+ + I+ + S K SL
Sbjct: 2998 WLKNEQPIKLNTNTLIVPGGRTLQ--IIRAKVSDGGEYTCIAINQAGESKKKFSL 3050
Score = 50.8 bits (120), Expect = 1e-05
Identities = 31/95 (32%), Positives = 45/95 (47%), Gaps = 10/95 (10%)
Query: 1355 FGGTVTTPWMKDVR----LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT-NGTLL 1409
F G + W++ + L C GDP P ++W + D I HR+ NG+L
Sbjct: 4351 FKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEI-----SHRIRQLGNGSLA 4405
Query: 1410 LRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP 1444
+ ED+G YTC ATN G ++L +Q PP
Sbjct: 4406 IYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPP 4440
Score = 50.1 bits (118), Expect = 2e-05
Identities = 48/199 (24%), Positives = 75/199 (37%), Gaps = 22/199 (11%)
Query: 753 VVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSL 812
V P G Y + G + CSVD P + + + QY ++ + +L
Sbjct: 433 VTMPEKTPGYYLQPGQIPCSVDSLLPFTLSFVRNGVTLGVDQY--------LKESASVNL 484
Query: 813 LIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTA 872
I V D G+Y C A + GT +++ F V P + PN G L C
Sbjct: 485 DIAKVTLSDEGFYECIAVSSAGTGRAQT-FFDVSEPPPVIQVPNNVTVTPGERAVLTCLI 543
Query: 873 RGERPIIIRWEKGD---TVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHA 929
+ W++ D + +P R+ A +L+LK D+ + C
Sbjct: 544 ISAVDYNLTWQRNDRDVRLAEPARIRTLANL----------SLELKSVKFNDAGEYHCMV 593
Query: 930 INSYGEDRGLIQLTVQEPP 948
+ G + LTVQEPP
Sbjct: 594 SSEGGSSAASVFLTVQEPP 612
Score = 49.7 bits (117), Expect = 3e-05
Identities = 35/101 (34%), Positives = 45/101 (44%), Gaps = 9/101 (8%)
Query: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLL-LRAVKAEDSGYYTCTA 1425
V L C + G P P++ W KD PVS+ I + G +L L ED+G YTC
Sbjct: 2404 VSLTCEASGIPLPSITWFKDGW----PVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVV 2459
Query: 1426 TNTGGFDTIIVNLLVQVPP----DQPRLTVSKTSASSITLT 1462
N G + I L V VPP + V S+TLT
Sbjct: 2460 RNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLT 2500
Score = 49.7 bits (117), Expect = 3e-05
Identities = 28/80 (35%), Positives = 42/80 (52%), Gaps = 4/80 (5%)
Query: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
K + L C + G P P + W KD AI S+ + + ++G+L + V+ D+G+YTC
Sbjct: 4094 KPITLSCEADGLPPPDITWHKDGR--AIVESI--RQRVLSSGSLQIAFVQPGDAGHYTCM 4149
Query: 1425 ATNTGGFDTIIVNLLVQVPP 1444
A N G + L V VPP
Sbjct: 4150 AANVAGSSSTSTKLTVHVPP 4169
Score = 44.7 bits (104), Expect = 0.001
Identities = 30/103 (29%), Positives = 49/103 (47%), Gaps = 14/103 (13%)
Query: 1367 VRLPCNSVGDPAPAVKWTKD----SEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYT 1422
V L C S P P + W K+ +E + + + DG +++H ++ + D+G Y
Sbjct: 3077 VSLECESNAVPPPVITWYKNGRMITESTHVEILADG-QMLH------IKKAEVSDTGQYV 3129
Query: 1423 CTATNTGGFDTIIVNLLVQVPPD---QPRLTVSKTSASSITLT 1462
C A N G D +L V VPP R + +T ++ +TLT
Sbjct: 3130 CRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLT 3172
Score = 43.9 bits (102), Expect = 0.002
Identities = 23/81 (28%), Positives = 44/81 (54%), Gaps = 5/81 (6%)
Query: 1365 KDVRLPCNSV-GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTC 1423
+ + LPC + G+P P +W K+S + + + + ++G+L + V+ +D G YTC
Sbjct: 905 QQLTLPCTLLAGNPIPERRWIKNSA----MLLQNPYITVRSDGSLHIERVQLQDGGEYTC 960
Query: 1424 TATNTGGFDTIIVNLLVQVPP 1444
A+N G + +++V V P
Sbjct: 961 VASNVAGTNNKTTSVVVHVLP 981
Score = 42.4 bits (98), Expect = 0.005
Identities = 26/103 (25%), Positives = 47/103 (45%), Gaps = 16/103 (15%)
Query: 1340 VTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH 1399
+T+EP +I+ GG + L C + G+P P + W++ +S D
Sbjct: 4442 ITLEPV----ETVINAGGKII--------LNCQATGEPQPTITWSRQGHS----ISWDDR 4485
Query: 1400 RLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQV 1442
+ +N +L + + ED+ + C A N G + V ++VQV
Sbjct: 4486 VNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQV 4528
Score = 42.0 bits (97), Expect = 0.006
Identities = 28/87 (32%), Positives = 42/87 (48%), Gaps = 8/87 (9%)
Query: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTAT 1426
+ L C + G PAP + W KD +P + D + + L + + ED+G YTC A+
Sbjct: 3546 LELTCIASGIPAPKMTWMKDGRP--LPQT-DQVQTLGGGEVLRISTAQVEDTGRYTCLAS 3602
Query: 1427 NTGGFDTIIVNLLVQVPP-----DQPR 1448
+ G D + V VPP D+PR
Sbjct: 3603 SPAGDDDKEYLVRVHVPPNIAGTDEPR 3629
Score = 40.0 bits (92), Expect = 0.024
Identities = 23/68 (33%), Positives = 37/68 (54%), Gaps = 6/68 (8%)
Query: 1366 DVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTN-GTLLLRAVKAEDSGYYTCT 1424
+V + C++ G P P + WT + D I + HR T+ GTL ++ +D+G Y C
Sbjct: 628 EVSIMCSATGYPKPKIAWTVN--DMFI---VGSHRYRMTSDGTLFIKNAAPKDAGIYGCL 682
Query: 1425 ATNTGGFD 1432
A+N+ G D
Sbjct: 683 ASNSAGTD 690
Score = 38.9 bits (89), Expect = 0.054
Identities = 31/106 (29%), Positives = 46/106 (43%), Gaps = 7/106 (6%)
Query: 1327 AVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTK- 1385
A+ AGR K+T++ +P I V+ +V LPC G P P +KW +
Sbjct: 774 AINEAGRATG--KITLDVG--SPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRL 829
Query: 1386 -DSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
+ + P S+ + T G L + + A D G Y C A N G
Sbjct: 830 DNMPIFSRPFSVSSISQLRT-GALFILNLWASDKGTYICEAENQFG 874
Score = 38.1 bits (87), Expect = 0.092
Identities = 32/118 (27%), Positives = 48/118 (40%), Gaps = 6/118 (5%)
Query: 1327 AVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKD 1386
AV+SAG G + + P +I VT + L C + + W ++
Sbjct: 501 AVSSAGTGRAQTFFDVSE----PPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRN 556
Query: 1387 SEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP 1444
D + L N +L L++VK D+G Y C ++ GG V L VQ PP
Sbjct: 557 DRDVRLAEPARIRTL--ANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPP 612
Score = 37.4 bits (85), Expect = 0.16
Identities = 30/95 (31%), Positives = 42/95 (44%), Gaps = 5/95 (5%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNT 1428
+ C + G P P VKW K + + L+ G L ++ + D+G YTC A N
Sbjct: 721 MECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLL---GLLKIQETQDLDAGDYTCVAINE 777
Query: 1429 GGFDTIIVNLLVQVPP--DQPRLTVSKTSASSITL 1461
G T + L V PP Q VS S++TL
Sbjct: 778 AGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTL 812
Score = 37.0 bits (84), Expect = 0.20
Identities = 23/81 (28%), Positives = 34/81 (41%), Gaps = 3/81 (3%)
Query: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
+ V L C S P P + W ++ E + R++ L + D+ YTC
Sbjct: 3637 RQVTLECKSDAVPPPVITWLRNGERLQATPRV---RILSGGRYLQINNADLGDTANYTCV 3693
Query: 1425 ATNTGGFDTIIVNLLVQVPPD 1445
A+N G T L V VPP+
Sbjct: 3694 ASNIAGKTTREFILTVNVPPN 3714
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 234 bits (597), Expect = 7e-61
Identities = 219/861 (25%), Positives = 358/861 (41%), Gaps = 88/861 (10%)
Query: 464 EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH-RTNQYTMS 522
ED PRIV S+ +V+ GE +L C A+G P PT+ W E + D R+++ +
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
Query: 523 DGTTISHMNVTGPQIR-DGGVYRCTARNLVGSA-EYQARINV-------RGPPSIRAMRN 573
G+ V G + R D GVY C ARN +G A + A + V R PS +
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-----D 139
Query: 574 ITAVAGRDTLINCRVI-GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632
+ G ++ C+ G+P +I W KD L D ++ G L +T +K D G+
Sbjct: 140 VMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS-DAGK 198
Query: 633 YLCSVLIQPQLSISQSVHVAV-KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWR 691
Y+C S+ + V + P ++ ++ C +P + WR
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT-VRWR 257
Query: 692 KD-GQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV-- 748
KD G++ S + + +L+I V+ G+YTC+A N L V+V
Sbjct: 258 KDDGELPKSRYEIRDDH-----TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 749 -PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQIL 807
PP FVV+P +Q G+ C G P P + W+ Y P + R +
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 808 PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI-----PAMITSHP-NTTIAI 861
L I +V D+GYY+CQ N G+ I+K+ + P +I P N T+A+
Sbjct: 373 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 432
Query: 862 KGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGD 921
G L+C A G I W K ++ I +NG L+++ A GD
Sbjct: 433 DG-TFVLSCVATGSPVPTILWRKDGVLVS---TQDSRIKQLENG-----VLQIRYAKLGD 483
Query: 922 SVFFSCHAINSYGEDRGLIQLTVQE----------------PPDPPELEIREVKARSMNL 965
+ ++C A GE + VQE P P + E+ +V ++ L
Sbjct: 484 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 543
Query: 966 RWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSF 1025
W + + T + IE + + ++ N+ + I L P ++Y + +
Sbjct: 544 SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVK--TETSAIKGLKPNAIYLFLVRAA 601
Query: 1026 NKIGRSEPSK-ELTISTEEAAPDGPPMD---------------VTLQPVTSQSIQVTWKA 1069
N G S+PS+ + T++ P +D ++S SI+V W
Sbjct: 602 NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV 661
Query: 1070 PKKELQNGVIRGYQIGYRENSPG-SNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQA 1128
+ Q+ I+GY+I YR + + + E++ + V + +L+K Y + +
Sbjct: 662 ---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIKARP 717
Query: 1129 FNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSD--VAVISWSEPPRSTLNGVLKGY 1186
F G S A TLE+ PS PP+ V + ++SW PP T NG+++ Y
Sbjct: 718 FFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY 777
Query: 1187 RVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQT 1246
+V W L + + + + + V + + YSV+V A T AG GV+S +IQ
Sbjct: 778 KV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 835
Query: 1247 KEDVPGPPAGIKAVPSSASSV 1267
D G P + S A +
Sbjct: 836 --DAHGNPVSPEDQVSLAQQI 854
Score = 139 bits (349), Expect = 4e-32
Identities = 144/491 (29%), Positives = 204/491 (41%), Gaps = 71/491 (14%)
Query: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP--------------LPADSR 331
P I++ V G L C A G P P I W K G LP+ S
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 332 WTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH--VTLTPKKLKTGIG 389
+ RI S D G Y+C N G A + + + L P + +G
Sbjct: 89 FFLRIVHGRKS---RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
Query: 390 STVILSC-ALTGSPEFTIRWYRN-TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCF 447
++ C G PE TI W ++ + L DE I+IRG L+IT +KS +G Y C
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG---GKLMITYTRKSDAGKYVCV 202
Query: 448 AT-----RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
T R+++ A+ + LE P V S V + C A+G P PTV W
Sbjct: 203 GTNMVGERESEVAE---LTVLE--RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562
D DG ++Y + D T+ VT D G Y C A N+VG AE A + V
Sbjct: 258 KD------DGELPKSRYEIRDDHTLKIRKVTA---GDMGSYTCVAENMVGKAEASATLTV 308
Query: 563 R----GPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA---LLL-----PDNHR 610
+ P + R+ GR C G P +I W ++ LL + R
Sbjct: 309 QVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 368
Query: 611 QVVFENGTLKLTDVQKGMDEGEYLC-------SVLIQPQLSISQSVHVAVKVPPLIQ--P 661
V + G L +T+VQ+ D G Y+C S++ + L ++ +A + PP+I+ P
Sbjct: 369 FSVSQTGDLTITNVQRS-DVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGP 425
Query: 662 FEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSL 721
A G + + CV + +P I WRKDG V++S I+ E LQI L
Sbjct: 426 VNQTVAVDGTFV-LSCVATGSPVP-TILWRKDG-VLVSTQDSRIKQLE-NGVLQIRYAKL 481
Query: 722 KHNGNYTCIAS 732
G YTCIAS
Sbjct: 482 GDTGRYTCIAS 492
Score = 135 bits (341), Expect = 3e-31
Identities = 201/863 (23%), Positives = 321/863 (37%), Gaps = 103/863 (11%)
Query: 374 PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDE------AISIRGLS 427
P + P L G L+C G P TI WY+ E V D+ + + S
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 428 NETLLITSAQKSH--SGAYQCFATRKAQTA----QDFAIIALEDGTPRIVSSFSEKVVNP 481
L I +KS G Y C A A + L D + S+ +V
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD---FRQNPSDVMVAV 144
Query: 482 GEQFSLMC-AAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDG 540
GE + C +G P PT++W D P+ + + T+ G + +T + D
Sbjct: 145 GEPAVMECQPPRGHPEPTISWKKDGSPL----DDKDERITIRGG----KLMITYTRKSDA 196
Query: 541 GVYRCTARNLVGSAEYQ-ARINVRGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKW 598
G Y C N+VG E + A + V PS ++ N+ C G P +++W
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 599 YKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC---SVLIQPQLSISQSVHVAVKV 655
KD LP + R + ++ TLK+ V G D G Y C +++ + + S + +V V +
Sbjct: 257 RKDDGELPKS-RYEIRDDHTLKIRKVTAG-DMGSYTCVAENMVGKAEASATLTVQVGSEP 314
Query: 656 PPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMS--- 712
P + ++G+ + C + P I WR++G + S +S S
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
Query: 713 --SLQISSVSLKHNGNYTCIASNAAATVSRERQLIV------RVPPRFVVQPNNQDGIYG 764
L I++V G Y C N A ++ + L V R PP P NQ
Sbjct: 374 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 765 KAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGY 824
VL+C G P P ++W+ + Q RI+ L N L IR+ D G
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQD-------SRIKQLENGVLQIRYAKLGDTGR 486
Query: 825 YLCQASNGVGTDISKSMFLTVK---IPAMITSHPNTTIAIKGHAKELNCTARGERPIIIR 881
Y C AS G + + S ++ V+ +P P I + T + +
Sbjct: 487 YTCIASTPSG-EATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 544
Query: 882 WEKG-DTVIDPDR--VMRYAIATKDNGDEVVSTLK-----LKPADRGDSVFFSCHAINSY 933
W+ ++ P + ++ A+ + V +K +K F A N+Y
Sbjct: 545 WQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY 604
Query: 934 G------------------EDRGLIQLTVQEPPDPPELEIRE---VKARSMNLRWTQRFD 972
G +G+ VQ L + + + S+ + WT
Sbjct: 605 GISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-Q 663
Query: 973 GNSIITGFDIEYK------NKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFN 1026
+ I G+ I Y+ +SD F+ T P N I DL Y I+ F
Sbjct: 664 QSQYIQGYKILYRPSGANHGESDWLVFEVRT----PAKNSVVIPDLRKGVNYEIKARPFF 719
Query: 1027 KIGRSEPSKELTISTEEAAPDGPPMDVTL--QPVTSQSIQVTWKAPKKELQNGVIRGYQI 1084
+ S+ T E AP PP VT+ +I V+W+ P ++ QNG+++ Y++
Sbjct: 720 NEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 779
Query: 1085 GYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINA 1143
G+ +Y I G + + L +Y V V A AG+G S +
Sbjct: 780 W----CLGNETRYHI-NKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQ 834
Query: 1144 TTLEDVPSQPPENVRALSITSDV 1166
P P + V SDV
Sbjct: 835 LDAHGNPVSPEDQVSLAQQISDV 857
Score = 129 bits (323), Expect = 4e-29
Identities = 186/836 (22%), Positives = 323/836 (38%), Gaps = 115/836 (13%)
Query: 579 GRDTLINCRVIGYPYYSIKWYKDALLL------PDNHRQVVFENGTLKLTDVQKGM---- 628
G +NC+ G P +I+WYK + P +HR ++ +G+L + G
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL-PSGSLFFLRIVHGRKSRP 101
Query: 629 DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPA----SIGQLLYIPCVVSSGDM 684
DEG Y+C + + L + S + +++V L F P+ ++G+ + C G
Sbjct: 102 DEGVYVC--VARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHP 159
Query: 685 PIRITWRKDGQVIIS-GSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRE-R 742
I+W+KDG + +TI + M I+ G Y C+ +N E
Sbjct: 160 EPTISWKKDGSPLDDKDERITIRGGKLM----ITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 743 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
+L V P FV +P+N + C G P P V W+ G +Y
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY------- 268
Query: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI---PAMITSHPNTTI 859
+I + +L IR V D+G Y C A N VG S LTV++ P P +
Sbjct: 269 --EIRDDHTLKIRKVTAGDMGSYTCVAENMVGK-AEASATLTVQVGSEPPHFVVKPRDQV 325
Query: 860 AIKGHAKELNCTARGERPIIIRWEKGDT------VIDPDRVMRYAIATKDNGDEVVSTLK 913
G C A G I W + + P R++++ GD ++ ++
Sbjct: 326 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS--QTGDLTITNVQ 383
Query: 914 LKPADRGDSVFFSCHAINSYGE--DRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRF 971
R D ++ C +N G + +++T PP + R + T
Sbjct: 384 -----RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV------IRQGPVNQTVAV 432
Query: 972 DGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGR- 1030
DG +++ + W + + + I L V IR GR
Sbjct: 433 DGTFVLSCVATGSPVPTILW----RKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRY 487
Query: 1031 ----SEPSKELTIST-----EEAAPDGPPM--DVTLQP----------VTSQSIQVTWKA 1069
S PS E T S E P PP D L P V+ ++ ++W+
Sbjct: 488 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP 547
Query: 1070 PKKELQNGVI-RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQA 1128
L +G Y I ++ GS+ Q +K +E + LK A Y +V+A
Sbjct: 548 ---NLNSGATPTSYIIEAFSHASGSSWQTVAENVK----TETSAIKGLKPNAIYLFLVRA 600
Query: 1129 FNRAGTGPSSSEINATTLEDV-PSQPPENVRALSITSDVAVISWSEPPRSTLNGV----- 1182
N G S + +DV P+ + + + AV+ P + + +
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 1183 -------LKGYRVIF---WSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQ 1232
++GY++++ + + + +W + T + V + + K NY ++ +
Sbjct: 661 VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720
Query: 1233 AGDGVRSSVLYIQTKEDVPG-PPAGIKAVPS--SASSVVVSWLPPTKP--NGVIRKYTIF 1287
G S + + +T E+ P PP G+ + + ++++VSW PP + NG++++Y ++
Sbjct: 721 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780
Query: 1288 CSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIE 1343
C + + S + I L G +Y + VAA T AG G SE I+
Sbjct: 781 CLGNETRYHINKTVDGSTFSVV--IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQ 834
Score = 126 bits (317), Expect = 2e-28
Identities = 133/480 (27%), Positives = 193/480 (40%), Gaps = 45/480 (9%)
Query: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIH-------DN 159
C A G P+ + WY G+ + H L P F +H +
Sbjct: 50 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHR----MLLPSGSLFFLRIVHGRKSRPDEG 104
Query: 160 DYFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218
Y C A N G+ S N ++ A+ R+ + D G AV +C P E
Sbjct: 105 VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE--PT 162
Query: 219 VSWEKDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
+SW+KD S + + IT GG L I+ +K DA Y C+ + GE R+S A L+
Sbjct: 163 ISWKKDG-SPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTNMV-GE-RESEVAELT 218
Query: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337
V + P+ + + V + E C A G P+P +RW KD LP +
Sbjct: 219 VLER----PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH 274
Query: 338 GLTISDLRTEDSGTYICEVTNTFGSAEATGILMV---IDPLHVTLTPKKLKTGIGSTVIL 394
L I + D G+Y C N G AEA+ L V +P H + P+ +G TV
Sbjct: 275 TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334
Query: 395 SCALTGSPEFTIRWYRNTELVL-----PDEAISIRGLSNE-TLLITSAQKSHSGAYQCFA 448
C TG+P+ I W R L P ++ S +S L IT+ Q+S G Y C
Sbjct: 335 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQT 394
Query: 449 TRKAQTAQDFAIIALED-----GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWAL 503
A + A + + D P I + V F L C A G+P PT+ W
Sbjct: 395 LNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR- 453
Query: 504 DDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR 563
D +V R Q + +G + + ++ D G Y C A G A + A I V+
Sbjct: 454 KDGVLVSTQDSRIKQ--LENGV----LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Score = 99.4 bits (246), Expect = 3e-20
Identities = 93/324 (28%), Positives = 140/324 (43%), Gaps = 26/324 (8%)
Query: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 220
Y C N G+ S + + R + R + + A FKC + + V V
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKC---EARGDPVPTVR 255
Query: 221 WEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD 280
W KD + P+ R+ I L I V D + +Y C+ ++ + A L+V
Sbjct: 256 WRKDDGEL-PKSRYEIRDDHTLKIRKVTAGD-MGSYTCVAENMVG---KAEASATLTVQV 310
Query: 281 PAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDG--------RPLPADSRW 332
+E P + Q V G TV C A+G P PAI W ++G +P + SR+
Sbjct: 311 GSEP-PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 333 TKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVID------PLHVTLTPKKLK 385
+ TG LTI++++ D G YIC+ N GS L V D P + P
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 386 TGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 445
+ T +LSC TGSP TI W ++ LV ++ I+ L N L I A+ +G Y
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYT 488
Query: 446 CFATRKAQTAQDFAIIALED-GTP 468
C A+ + A A I +++ G P
Sbjct: 489 CIASTPSGEATWSAYIEVQEFGVP 512
Score = 69.3 bits (168), Expect = 4e-11
Identities = 76/310 (24%), Positives = 121/310 (39%), Gaps = 44/310 (14%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT-NGTLLLRAVKAEDSGYYTCTATN 1427
L C + G P P + W KD + VS R+ NG L +R K D+G YTC A+
Sbjct: 438 LSCVATGSPVPTILWRKDG----VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 1428 TGGFDTIIVNLLVQ---VPPDQPRLT-------------VSKTSASSITLTWIPGDNGGS 1471
G T + VQ VP PR T V+ S +++TL+W P N G+
Sbjct: 494 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 553
Query: 1472 SIRGFVLQ-YSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEII 1530
+ ++++ +S + W+ V + + + LK Y + A N+ G S+I
Sbjct: 554 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 613
Query: 1531 E-AKTHGREPSFSKDQHLFTHINSTHARLNLQG------------W--NNGGCPITAIVL 1575
+ KT P+ H +A L+L W + I +
Sbjct: 614 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 673
Query: 1576 EYRPKGT------WAWQGLRANSSGEVFLTELREATWYELRMRA-CNSAGCGNETAQFAT 1628
YRP G W +R + V + +LR+ YE++ R N + +FA
Sbjct: 674 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 733
Query: 1629 LDYDGSTIPP 1638
+ + PP
Sbjct: 734 TLEEAPSAPP 743
Score = 51.2 bits (121), Expect = 1e-05
Identities = 33/81 (40%), Positives = 38/81 (46%), Gaps = 5/81 (6%)
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
C + GDP P V+W KD D +P S R HT L +R V A D G YTC A N G
Sbjct: 244 CEARGDPVPTVRWRKD--DGELPKSRYEIRDDHT---LKIRKVTAGDMGSYTCVAENMVG 298
Query: 1431 FDTIIVNLLVQVPPDQPRLTV 1451
L VQV + P V
Sbjct: 299 KAEASATLTVQVGSEPPHFVV 319
Score = 47.4 bits (111), Expect = 2e-04
Identities = 72/362 (19%), Positives = 128/362 (35%), Gaps = 54/362 (14%)
Query: 1294 GQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPA--- 1350
G+ S YE + +I + G A G+ +S +T++ + P
Sbjct: 261 GELPKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 1351 ----KIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAI----PVSMDGHRLI 1402
++++ G TVT C + G+P PA+ W ++ + + P +
Sbjct: 320 KPRDQVVALGRTVT--------FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 371
Query: 1403 HTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP---PDQPRLTVSKTSASSI 1459
G L + V+ D GYY C N G +II ++V D+P + + +
Sbjct: 372 SQTGDLTITNVQRSDVGYYICQTLNVAG--SIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 1460 TLTWIPGDNGGSSIRGFVLQYSVDNSEEWK--DVFISSSERSFK--------LDSLKCGT 1509
G+ + V S + W+ V +S+ + K + K G
Sbjct: 430 VAV------DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGD 483
Query: 1510 WYKVKLAAKNSVGSGRISEIIEAKTHG--REPSFSKDQHLF---------THINSTHARL 1558
+ A G S IE + G +P D +L T ++ L
Sbjct: 484 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 543
Query: 1559 NLQ-GWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEV-FLTELREATWYELRMRACNS 1616
+ Q N+G P + I+ + +WQ + N E + L+ Y +RA N+
Sbjct: 544 SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANA 603
Query: 1617 AG 1618
G
Sbjct: 604 YG 605
Score = 40.4 bits (93), Expect = 0.019
Identities = 36/171 (21%), Positives = 62/171 (36%), Gaps = 14/171 (8%)
Query: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATN-TGGFDT 1433
G P P + W KD P+ R+ G L++ + D+G Y C TN G ++
Sbjct: 157 GHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
Query: 1434 IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGF---VLQYSVDNSEEWKD 1490
+ L V P + S++ +T RG +++ D+ E K
Sbjct: 213 EVAELTVLERPSFVK------RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 1491 VFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSF 1541
+ + + K+ + G A+N VG S + + P F
Sbjct: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Score = 34.7 bits (78), Expect = 1.0
Identities = 26/88 (29%), Positives = 37/88 (42%), Gaps = 12/88 (13%)
Query: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE----DSAIPVSMDGHRLIHT 1404
P +I+ + + L C + G P P ++W K E D P S HR++
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLP 84
Query: 1405 NGTL-LLRAVKAE----DSGYYTCTATN 1427
+G+L LR V D G Y C A N
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARN 112
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 234 bits (597), Expect = 7e-61
Identities = 219/861 (25%), Positives = 358/861 (41%), Gaps = 88/861 (10%)
Query: 464 EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH-RTNQYTMS 522
ED PRIV S+ +V+ GE +L C A+G P PT+ W E + D R+++ +
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
Query: 523 DGTTISHMNVTGPQIR-DGGVYRCTARNLVGSA-EYQARINV-------RGPPSIRAMRN 573
G+ V G + R D GVY C ARN +G A + A + V R PS +
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-----D 139
Query: 574 ITAVAGRDTLINCRVI-GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632
+ G ++ C+ G+P +I W KD L D ++ G L +T +K D G+
Sbjct: 140 VMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS-DAGK 198
Query: 633 YLCSVLIQPQLSISQSVHVAV-KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWR 691
Y+C S+ + V + P ++ ++ C +P + WR
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT-VRWR 257
Query: 692 KD-GQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV-- 748
KD G++ S + + +L+I V+ G+YTC+A N L V+V
Sbjct: 258 KDDGELPKSRYEIRDDH-----TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 749 -PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQIL 807
PP FVV+P +Q G+ C G P P + W+ Y P + R +
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 808 PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI-----PAMITSHP-NTTIAI 861
L I +V D+GYY+CQ N G+ I+K+ + P +I P N T+A+
Sbjct: 373 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 432
Query: 862 KGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGD 921
G L+C A G I W K ++ I +NG L+++ A GD
Sbjct: 433 DG-TFVLSCVATGSPVPTILWRKDGVLVS---TQDSRIKQLENG-----VLQIRYAKLGD 483
Query: 922 SVFFSCHAINSYGEDRGLIQLTVQE----------------PPDPPELEIREVKARSMNL 965
+ ++C A GE + VQE P P + E+ +V ++ L
Sbjct: 484 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 543
Query: 966 RWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSF 1025
W + + T + IE + + ++ N+ + I L P ++Y + +
Sbjct: 544 SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVK--TETSAIKGLKPNAIYLFLVRAA 601
Query: 1026 NKIGRSEPSK-ELTISTEEAAPDGPPMD---------------VTLQPVTSQSIQVTWKA 1069
N G S+PS+ + T++ P +D ++S SI+V W
Sbjct: 602 NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV 661
Query: 1070 PKKELQNGVIRGYQIGYRENSPG-SNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQA 1128
+ Q+ I+GY+I YR + + + E++ + V + +L+K Y + +
Sbjct: 662 ---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIKARP 717
Query: 1129 FNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSD--VAVISWSEPPRSTLNGVLKGY 1186
F G S A TLE+ PS PP+ V + ++SW PP T NG+++ Y
Sbjct: 718 FFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY 777
Query: 1187 RVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQT 1246
+V W L + + + + + V + + YSV+V A T AG GV+S +IQ
Sbjct: 778 KV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 835
Query: 1247 KEDVPGPPAGIKAVPSSASSV 1267
D G P + S A +
Sbjct: 836 --DAHGNPVSPEDQVSLAQQI 854
Score = 139 bits (349), Expect = 4e-32
Identities = 144/491 (29%), Positives = 204/491 (41%), Gaps = 71/491 (14%)
Query: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP--------------LPADSR 331
P I++ V G L C A G P P I W K G LP+ S
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 332 WTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH--VTLTPKKLKTGIG 389
+ RI S D G Y+C N G A + + + L P + +G
Sbjct: 89 FFLRIVHGRKS---RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
Query: 390 STVILSC-ALTGSPEFTIRWYRN-TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCF 447
++ C G PE TI W ++ + L DE I+IRG L+IT +KS +G Y C
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG---GKLMITYTRKSDAGKYVCV 202
Query: 448 AT-----RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
T R+++ A+ + LE P V S V + C A+G P PTV W
Sbjct: 203 GTNMVGERESEVAE---LTVLE--RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562
D DG ++Y + D T+ VT D G Y C A N+VG AE A + V
Sbjct: 258 KD------DGELPKSRYEIRDDHTLKIRKVTA---GDMGSYTCVAENMVGKAEASATLTV 308
Query: 563 R----GPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA---LLL-----PDNHR 610
+ P + R+ GR C G P +I W ++ LL + R
Sbjct: 309 QVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 368
Query: 611 QVVFENGTLKLTDVQKGMDEGEYLC-------SVLIQPQLSISQSVHVAVKVPPLIQ--P 661
V + G L +T+VQ+ D G Y+C S++ + L ++ +A + PP+I+ P
Sbjct: 369 FSVSQTGDLTITNVQRS-DVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGP 425
Query: 662 FEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSL 721
A G + + CV + +P I WRKDG V++S I+ E LQI L
Sbjct: 426 VNQTVAVDGTFV-LSCVATGSPVP-TILWRKDG-VLVSTQDSRIKQLE-NGVLQIRYAKL 481
Query: 722 KHNGNYTCIAS 732
G YTCIAS
Sbjct: 482 GDTGRYTCIAS 492
Score = 135 bits (341), Expect = 3e-31
Identities = 201/863 (23%), Positives = 321/863 (37%), Gaps = 103/863 (11%)
Query: 374 PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDE------AISIRGLS 427
P + P L G L+C G P TI WY+ E V D+ + + S
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 428 NETLLITSAQKSH--SGAYQCFATRKAQTA----QDFAIIALEDGTPRIVSSFSEKVVNP 481
L I +KS G Y C A A + L D + S+ +V
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD---FRQNPSDVMVAV 144
Query: 482 GEQFSLMC-AAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDG 540
GE + C +G P PT++W D P+ + + T+ G + +T + D
Sbjct: 145 GEPAVMECQPPRGHPEPTISWKKDGSPL----DDKDERITIRGG----KLMITYTRKSDA 196
Query: 541 GVYRCTARNLVGSAEYQ-ARINVRGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKW 598
G Y C N+VG E + A + V PS ++ N+ C G P +++W
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 599 YKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC---SVLIQPQLSISQSVHVAVKV 655
KD LP + R + ++ TLK+ V G D G Y C +++ + + S + +V V +
Sbjct: 257 RKDDGELPKS-RYEIRDDHTLKIRKVTAG-DMGSYTCVAENMVGKAEASATLTVQVGSEP 314
Query: 656 PPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMS--- 712
P + ++G+ + C + P I WR++G + S +S S
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
Query: 713 --SLQISSVSLKHNGNYTCIASNAAATVSRERQLIV------RVPPRFVVQPNNQDGIYG 764
L I++V G Y C N A ++ + L V R PP P NQ
Sbjct: 374 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 765 KAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGY 824
VL+C G P P ++W+ + Q RI+ L N L IR+ D G
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQD-------SRIKQLENGVLQIRYAKLGDTGR 486
Query: 825 YLCQASNGVGTDISKSMFLTVK---IPAMITSHPNTTIAIKGHAKELNCTARGERPIIIR 881
Y C AS G + + S ++ V+ +P P I + T + +
Sbjct: 487 YTCIASTPSG-EATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 544
Query: 882 WEKG-DTVIDPDR--VMRYAIATKDNGDEVVSTLK-----LKPADRGDSVFFSCHAINSY 933
W+ ++ P + ++ A+ + V +K +K F A N+Y
Sbjct: 545 WQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY 604
Query: 934 G------------------EDRGLIQLTVQEPPDPPELEIRE---VKARSMNLRWTQRFD 972
G +G+ VQ L + + + S+ + WT
Sbjct: 605 GISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-Q 663
Query: 973 GNSIITGFDIEYK------NKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFN 1026
+ I G+ I Y+ +SD F+ T P N I DL Y I+ F
Sbjct: 664 QSQYIQGYKILYRPSGANHGESDWLVFEVRT----PAKNSVVIPDLRKGVNYEIKARPFF 719
Query: 1027 KIGRSEPSKELTISTEEAAPDGPPMDVTL--QPVTSQSIQVTWKAPKKELQNGVIRGYQI 1084
+ S+ T E AP PP VT+ +I V+W+ P ++ QNG+++ Y++
Sbjct: 720 NEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 779
Query: 1085 GYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINA 1143
G+ +Y I G + + L +Y V V A AG+G S +
Sbjct: 780 W----CLGNETRYHI-NKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQ 834
Query: 1144 TTLEDVPSQPPENVRALSITSDV 1166
P P + V SDV
Sbjct: 835 LDAHGNPVSPEDQVSLAQQISDV 857
Score = 129 bits (323), Expect = 4e-29
Identities = 186/836 (22%), Positives = 323/836 (38%), Gaps = 115/836 (13%)
Query: 579 GRDTLINCRVIGYPYYSIKWYKDALLL------PDNHRQVVFENGTLKLTDVQKGM---- 628
G +NC+ G P +I+WYK + P +HR ++ +G+L + G
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL-PSGSLFFLRIVHGRKSRP 101
Query: 629 DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPA----SIGQLLYIPCVVSSGDM 684
DEG Y+C + + L + S + +++V L F P+ ++G+ + C G
Sbjct: 102 DEGVYVC--VARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHP 159
Query: 685 PIRITWRKDGQVIIS-GSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRE-R 742
I+W+KDG + +TI + M I+ G Y C+ +N E
Sbjct: 160 EPTISWKKDGSPLDDKDERITIRGGKLM----ITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 743 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
+L V P FV +P+N + C G P P V W+ G +Y
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY------- 268
Query: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI---PAMITSHPNTTI 859
+I + +L IR V D+G Y C A N VG S LTV++ P P +
Sbjct: 269 --EIRDDHTLKIRKVTAGDMGSYTCVAENMVGK-AEASATLTVQVGSEPPHFVVKPRDQV 325
Query: 860 AIKGHAKELNCTARGERPIIIRWEKGDT------VIDPDRVMRYAIATKDNGDEVVSTLK 913
G C A G I W + + P R++++ GD ++ ++
Sbjct: 326 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS--QTGDLTITNVQ 383
Query: 914 LKPADRGDSVFFSCHAINSYGE--DRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRF 971
R D ++ C +N G + +++T PP + R + T
Sbjct: 384 -----RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV------IRQGPVNQTVAV 432
Query: 972 DGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGR- 1030
DG +++ + W + + + I L V IR GR
Sbjct: 433 DGTFVLSCVATGSPVPTILW----RKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRY 487
Query: 1031 ----SEPSKELTIST-----EEAAPDGPPM--DVTLQP----------VTSQSIQVTWKA 1069
S PS E T S E P PP D L P V+ ++ ++W+
Sbjct: 488 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP 547
Query: 1070 PKKELQNGVI-RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQA 1128
L +G Y I ++ GS+ Q +K +E + LK A Y +V+A
Sbjct: 548 ---NLNSGATPTSYIIEAFSHASGSSWQTVAENVK----TETSAIKGLKPNAIYLFLVRA 600
Query: 1129 FNRAGTGPSSSEINATTLEDV-PSQPPENVRALSITSDVAVISWSEPPRSTLNGV----- 1182
N G S + +DV P+ + + + AV+ P + + +
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 1183 -------LKGYRVIF---WSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQ 1232
++GY++++ + + + +W + T + V + + K NY ++ +
Sbjct: 661 VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720
Query: 1233 AGDGVRSSVLYIQTKEDVPG-PPAGIKAVPS--SASSVVVSWLPPTKP--NGVIRKYTIF 1287
G S + + +T E+ P PP G+ + + ++++VSW PP + NG++++Y ++
Sbjct: 721 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780
Query: 1288 CSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIE 1343
C + + S + I L G +Y + VAA T AG G SE I+
Sbjct: 781 CLGNETRYHINKTVDGSTFSVV--IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQ 834
Score = 126 bits (317), Expect = 2e-28
Identities = 133/480 (27%), Positives = 193/480 (40%), Gaps = 45/480 (9%)
Query: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIH-------DN 159
C A G P+ + WY G+ + H L P F +H +
Sbjct: 50 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHR----MLLPSGSLFFLRIVHGRKSRPDEG 104
Query: 160 DYFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218
Y C A N G+ S N ++ A+ R+ + D G AV +C P E
Sbjct: 105 VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE--PT 162
Query: 219 VSWEKDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
+SW+KD S + + IT GG L I+ +K DA Y C+ + GE R+S A L+
Sbjct: 163 ISWKKDG-SPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTNMV-GE-RESEVAELT 218
Query: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337
V + P+ + + V + E C A G P+P +RW KD LP +
Sbjct: 219 VLER----PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH 274
Query: 338 GLTISDLRTEDSGTYICEVTNTFGSAEATGILMV---IDPLHVTLTPKKLKTGIGSTVIL 394
L I + D G+Y C N G AEA+ L V +P H + P+ +G TV
Sbjct: 275 TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334
Query: 395 SCALTGSPEFTIRWYRNTELVL-----PDEAISIRGLSNE-TLLITSAQKSHSGAYQCFA 448
C TG+P+ I W R L P ++ S +S L IT+ Q+S G Y C
Sbjct: 335 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQT 394
Query: 449 TRKAQTAQDFAIIALED-----GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWAL 503
A + A + + D P I + V F L C A G+P PT+ W
Sbjct: 395 LNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR- 453
Query: 504 DDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR 563
D +V R Q + +G + + ++ D G Y C A G A + A I V+
Sbjct: 454 KDGVLVSTQDSRIKQ--LENGV----LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Score = 99.4 bits (246), Expect = 3e-20
Identities = 93/324 (28%), Positives = 140/324 (43%), Gaps = 26/324 (8%)
Query: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 220
Y C N G+ S + + R + R + + A FKC + + V V
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKC---EARGDPVPTVR 255
Query: 221 WEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD 280
W KD + P+ R+ I L I V D + +Y C+ ++ + A L+V
Sbjct: 256 WRKDDGEL-PKSRYEIRDDHTLKIRKVTAGD-MGSYTCVAENMVG---KAEASATLTVQV 310
Query: 281 PAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDG--------RPLPADSRW 332
+E P + Q V G TV C A+G P PAI W ++G +P + SR+
Sbjct: 311 GSEP-PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 333 TKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVID------PLHVTLTPKKLK 385
+ TG LTI++++ D G YIC+ N GS L V D P + P
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 386 TGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 445
+ T +LSC TGSP TI W ++ LV ++ I+ L N L I A+ +G Y
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYT 488
Query: 446 CFATRKAQTAQDFAIIALED-GTP 468
C A+ + A A I +++ G P
Sbjct: 489 CIASTPSGEATWSAYIEVQEFGVP 512
Score = 69.3 bits (168), Expect = 4e-11
Identities = 76/310 (24%), Positives = 121/310 (39%), Gaps = 44/310 (14%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT-NGTLLLRAVKAEDSGYYTCTATN 1427
L C + G P P + W KD + VS R+ NG L +R K D+G YTC A+
Sbjct: 438 LSCVATGSPVPTILWRKDG----VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 1428 TGGFDTIIVNLLVQ---VPPDQPRLT-------------VSKTSASSITLTWIPGDNGGS 1471
G T + VQ VP PR T V+ S +++TL+W P N G+
Sbjct: 494 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 553
Query: 1472 SIRGFVLQ-YSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEII 1530
+ ++++ +S + W+ V + + + LK Y + A N+ G S+I
Sbjct: 554 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 613
Query: 1531 E-AKTHGREPSFSKDQHLFTHINSTHARLNLQG------------W--NNGGCPITAIVL 1575
+ KT P+ H +A L+L W + I +
Sbjct: 614 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 673
Query: 1576 EYRPKGT------WAWQGLRANSSGEVFLTELREATWYELRMRA-CNSAGCGNETAQFAT 1628
YRP G W +R + V + +LR+ YE++ R N + +FA
Sbjct: 674 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 733
Query: 1629 LDYDGSTIPP 1638
+ + PP
Sbjct: 734 TLEEAPSAPP 743
Score = 51.2 bits (121), Expect = 1e-05
Identities = 33/81 (40%), Positives = 38/81 (46%), Gaps = 5/81 (6%)
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
C + GDP P V+W KD D +P S R HT L +R V A D G YTC A N G
Sbjct: 244 CEARGDPVPTVRWRKD--DGELPKSRYEIRDDHT---LKIRKVTAGDMGSYTCVAENMVG 298
Query: 1431 FDTIIVNLLVQVPPDQPRLTV 1451
L VQV + P V
Sbjct: 299 KAEASATLTVQVGSEPPHFVV 319
Score = 47.4 bits (111), Expect = 2e-04
Identities = 72/362 (19%), Positives = 128/362 (35%), Gaps = 54/362 (14%)
Query: 1294 GQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPA--- 1350
G+ S YE + +I + G A G+ +S +T++ + P
Sbjct: 261 GELPKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 1351 ----KIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAI----PVSMDGHRLI 1402
++++ G TVT C + G+P PA+ W ++ + + P +
Sbjct: 320 KPRDQVVALGRTVT--------FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 371
Query: 1403 HTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP---PDQPRLTVSKTSASSI 1459
G L + V+ D GYY C N G +II ++V D+P + + +
Sbjct: 372 SQTGDLTITNVQRSDVGYYICQTLNVAG--SIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 1460 TLTWIPGDNGGSSIRGFVLQYSVDNSEEWK--DVFISSSERSFK--------LDSLKCGT 1509
G+ + V S + W+ V +S+ + K + K G
Sbjct: 430 VAV------DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGD 483
Query: 1510 WYKVKLAAKNSVGSGRISEIIEAKTHG--REPSFSKDQHLF---------THINSTHARL 1558
+ A G S IE + G +P D +L T ++ L
Sbjct: 484 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 543
Query: 1559 NLQ-GWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEV-FLTELREATWYELRMRACNS 1616
+ Q N+G P + I+ + +WQ + N E + L+ Y +RA N+
Sbjct: 544 SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANA 603
Query: 1617 AG 1618
G
Sbjct: 604 YG 605
Score = 40.4 bits (93), Expect = 0.019
Identities = 36/171 (21%), Positives = 62/171 (36%), Gaps = 14/171 (8%)
Query: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATN-TGGFDT 1433
G P P + W KD P+ R+ G L++ + D+G Y C TN G ++
Sbjct: 157 GHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
Query: 1434 IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGF---VLQYSVDNSEEWKD 1490
+ L V P + S++ +T RG +++ D+ E K
Sbjct: 213 EVAELTVLERPSFVK------RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 1491 VFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSF 1541
+ + + K+ + G A+N VG S + + P F
Sbjct: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Score = 34.7 bits (78), Expect = 1.0
Identities = 26/88 (29%), Positives = 37/88 (42%), Gaps = 12/88 (13%)
Query: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE----DSAIPVSMDGHRLIHT 1404
P +I+ + + L C + G P P ++W K E D P S HR++
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLP 84
Query: 1405 NGTL-LLRAVKAE----DSGYYTCTATN 1427
+G+L LR V D G Y C A N
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARN 112
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 234 bits (597), Expect = 7e-61
Identities = 259/1002 (25%), Positives = 419/1002 (41%), Gaps = 93/1002 (9%)
Query: 680 SSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS-LQISSVSL-KHNGNYTCIASNAAAT 737
++GD +I W K G+ + + IE + S L+I + + Y C+ASN
Sbjct: 47 ATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGE 106
Query: 738 VSRERQLIV----RVP---PRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSG 790
+S +L V ++P P + P + + + C+ G P P++ W
Sbjct: 107 ISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWF------ 160
Query: 791 NPQQYHPVPLT---GRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI 847
+ + PV + GRI+ L + +L I E D G Y C A+N GT S L V++
Sbjct: 161 --KDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRV 218
Query: 848 ---PAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDN 904
P + P + G + + C A G ++W G + P+
Sbjct: 219 RRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPE------------ 266
Query: 905 GDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEI-REVKARSM 963
D + L+ D S ++C A+++ G + Q+TV+ P PP + E A S+
Sbjct: 267 DDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSI 326
Query: 964 NLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMY 1023
L W GN + I +S + + ++ T + ++ L P S Y R+
Sbjct: 327 TLTWDS---GNPEPVSYYIIQHKPKNSEELYKEIDGVATT--RYSVAGLSPYSDYEFRVV 381
Query: 1024 SFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQ 1083
+ N IGR PS+ + T E AP P DV + ++S +I V WK P E NG I+GY+
Sbjct: 382 AVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEP--EEPNGQIQGYR 439
Query: 1084 IGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINA 1143
+ Y + + DS++ T+ NL Y V V AF G GP SS+I
Sbjct: 440 VYYTMDPTQHVNNWM---KHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQV 496
Query: 1144 TTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQ 1203
T VP Q P N +A + ++SW+ PPRS + Y ++ Y DGE GE Q
Sbjct: 497 ITQTGVPGQ-PLNFKAEPESETSILLSWT-PPRS---DTIANYELV----YKDGEHGEEQ 547
Query: 1204 NIT-TTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP-GPPAGIKAVP 1261
IT L+G++ + Y ++ A + G G ++ + +T + P PP I
Sbjct: 548 RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 607
Query: 1262 SSASSVVVSWLPP--TKPNGVIRKYTIFCSSPGSGQPAPSEYETSP-EQLFYRIAHLNRG 1318
S++S++VSW PP K NG+I +Y+I ++ P E P + Y + L +
Sbjct: 608 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 667
Query: 1319 QQYLLWVAAVTSAGRGNSSEKVTI---EPAGKAPAKIISFGGTVTTPWMKDVRLPCNSV- 1374
+Y + V A T G G S V I E P + + +T R P +
Sbjct: 668 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 727
Query: 1375 -----GDPAPAVKWTKDSEDSAIPVSMDGHRL-------IHTNGTLLLRAVKAEDSGYYT 1422
G V+ ++ E P+ D T +++ ++ E S T
Sbjct: 728 HGQIRGYQVHYVR-MENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLT 786
Query: 1423 CTATNTGGFDTIIVNLLVQVP---PDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQ 1479
TA T G LV P +PRL ++ T ++ + W P + ++G+ L+
Sbjct: 787 VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLK 846
Query: 1480 YSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREP 1539
+ + E + S E F + G Y +L+A+N VG G E+++ + E
Sbjct: 847 FGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEV 904
Query: 1540 SFSKDQHLFTH-INSTHARLNLQ----GWNNGGCPITAIVLEYRPKG--TWAWQGLRANS 1592
Q+L + ST +L+ Q NG IT L YR + L +
Sbjct: 905 PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNG--IITKYTLLYRDINIPLLPMEQLIVPA 962
Query: 1593 SGEVFLTELREATWYELRMRACNSAGCG--NETAQFATLDYD 1632
+ LT L+ T Y++++RA S G G + + QF TL D
Sbjct: 963 DTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVD 1004
Score = 221 bits (562), Expect = 8e-57
Identities = 264/1078 (24%), Positives = 436/1078 (40%), Gaps = 146/1078 (13%)
Query: 547 ARNLVGSAEYQARINVRGPPSI-RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLL 605
AR L+ + R + PP R + T V+G C+ G P I W K +
Sbjct: 5 ARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKV 64
Query: 606 PDNHRQVV-FENGT---LKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQP 661
+ +V+ F++G+ L++ ++ DE Y C V IS S + V I P
Sbjct: 65 SNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYEC-VASNNVGEISVSTRLTVLREDQI-P 122
Query: 662 FEFPPASIGQLLYIP--------CVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS 713
FP +G L + +SG+ ITW KD + + + + +
Sbjct: 123 RGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGA 182
Query: 714 LQISSVSLKHNGNYTCIASNAAAT-VSRERQLIVRV---PPRFVVQPNNQDGIYGKAGVL 769
LQI G Y C+A+N+A T S L VRV PPRF + P N + + G + +
Sbjct: 183 LQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNI 242
Query: 770 NCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLE----EDIGYY 825
C G P P V W P+ P+ R+VLE Y
Sbjct: 243 TCVAVGSPMPYVKWMLGAEDLTPEDDMPIG---------------RNVLELNDVRQSANY 287
Query: 826 LCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKG 885
C A + +G I +TVK + P T + + A + T W+ G
Sbjct: 288 TCVAMSTLGV-IEAIAQITVKA---LPKPPGTPVVTESTATSITLT----------WDSG 333
Query: 886 DTVIDPDRVMRYAIATKDNGDEV-------VSTLKLKPADRG--DSVFFSCHAINSYGE- 935
+ P+ V Y I K E V+T + A F A+N+ G
Sbjct: 334 N----PEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRG 389
Query: 936 ---DRGLIQLTVQEPPDPP-ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSW 991
+ L Q + Q P P +++ R + + ++ ++W + + N I G+ + Y
Sbjct: 390 PPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQH 449
Query: 992 DFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPM 1051
N++ + I +L P YS+++ +F IG S ++ + T+ P G P+
Sbjct: 450 VNNWMKHNVADS-QITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP-GQPL 507
Query: 1052 DVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVY 1111
+ +P + SI ++W P+ + I Y++ Y++ G + +I G S Y
Sbjct: 508 NFKAEPESETSILLSWTPPRSD----TIANYELVYKDGEHGEEQRITI----EPGTS--Y 557
Query: 1112 TLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISW 1171
L LK + Y + A + G G S++EI+A T++ PS PP+++ S +S ++SW
Sbjct: 558 RLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSW 617
Query: 1172 SEPPRSTLNGVLKGYRVIFWSLYVDGEWG---EMQNITTTRERVELRGMEKFTNYSVQVL 1228
PP NG++ Y + + + VDGE E+ I + + L +EK+T Y + V
Sbjct: 618 QPPPVEKQNGIITEYSIKYTA--VDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVT 675
Query: 1229 AYTQAGDGVRSSVLYIQTKEDVP-GPPAGIKAVPSSASSVVVSWLPPT--KPNGVIRKYT 1285
A+T G G S + I+T EDVP GPP ++ +++SV VSW P K +G IR Y
Sbjct: 676 AHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQ 735
Query: 1286 IFCSSPGSGQP-------------APSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAG 1332
+ +G+P A E++ + E I+ L Y L V A T+ G
Sbjct: 736 VHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI-ISGLQPETSYSLTVTAYTTKG 794
Query: 1333 RGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAI 1392
G S+ + G P K RL N ++W +
Sbjct: 795 DGARSKPKLVSTTGAVPGK---------------PRLVINHTQMNTALIQWHPPVDTFG- 838
Query: 1393 PVSMDGHRLIHTNGTL--LLRAVKAEDSGYYTCT-------------ATNTGGFDTIIVN 1437
+ G+RL + L +E ++T T A N GF +V
Sbjct: 839 --PLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 896
Query: 1438 LLVQVPPDQP-----RLTVSKTSASSITLTWIP---GDNGGSSIRGFVLQYSVDNSEEWK 1489
+ +P + P L T+++S+ L+W P + G + +L ++
Sbjct: 897 E-ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPM 955
Query: 1490 DVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHL 1547
+ I ++ + L LK T Y VK+ A S G G S ++ +T + F+K+ H+
Sbjct: 956 EQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHV 1013
Score = 186 bits (472), Expect = 2e-46
Identities = 239/1059 (22%), Positives = 408/1059 (38%), Gaps = 100/1059 (9%)
Query: 468 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTI 527
PR + ++ G S +C A G P P + W + V + ++ G+ +
Sbjct: 24 PRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKK-VSNQRFEVIEFDDGSGSVL 82
Query: 528 SHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV-------RGPPSIRAMRNITAVAG- 579
+ P RD +Y C A N VG R+ V RG P+I + V
Sbjct: 83 RIQPLRTP--RDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERT 140
Query: 580 RDTLINCRVIGYPYYSIKWYKDALLLP---DNHRQVVFENGTLKLTDVQKGMDEGEYLCS 636
R + C G P I W+KD L + +N R +G L++ ++ D+G+Y C
Sbjct: 141 RTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEES-DQGKYECV 199
Query: 637 VLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI----GQLLYIPCVVSSGDMPIRITWRK 692
S ++ V+V + F PP + G + I CV MP + W
Sbjct: 200 ATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPY-VKW-- 256
Query: 693 DGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRF 752
++ +T E + + ++ + NYTC+A + + Q+ V+ P+
Sbjct: 257 ----MLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPK- 311
Query: 753 VVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWK--HAKGSGNPQQYHPVP--LTGRIQIL- 807
P A + + D P V + K + + Y + T R +
Sbjct: 312 --PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAG 369
Query: 808 --PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKG-H 864
P S R V +IG S V T S+ + +TTI ++
Sbjct: 370 LSPYSDYEFRVVAVNNIGRG--PPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKE 427
Query: 865 AKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVF 924
+E N +G R D + M++ +A D ++T+ + SV
Sbjct: 428 PEEPNGQIQGYRVYYTM----DPTQHVNNWMKHNVA-----DSQITTIGNLVPQKTYSVK 478
Query: 925 FSCHAINSYGEDRGLIQLTVQE--PPDPPELEIREVKARSMNLRWTQRFDGNSIITGFDI 982
G IQ+ Q P P + S+ L WT + I +++
Sbjct: 479 VLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTP--PRSDTIANYEL 536
Query: 983 EYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTE 1042
YK D ++ I P + + L P S+Y R+ + + G + E++ T
Sbjct: 537 VYK---DGEHGEEQRITIEPGTSY-RLQGLKPNSLYYFRLAARSPQGLGASTAEISARTM 592
Query: 1043 EAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEM 1102
++ P PP D++ +S SI V+W+ P E QNG+I Y I Y + + I+ +
Sbjct: 593 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGI 652
Query: 1103 KATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSI 1162
+ D+ Y L+ L+K+ +Y + V A G GP S + T EDVPS PP V ++
Sbjct: 653 PS--DTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAV 710
Query: 1163 TSDVAVISWSEPPRSTLNGVLKGYRVIFWS---------------LYVDGEWGEMQNITT 1207
S +SW P + +G ++GY+V + + D +W + T
Sbjct: 711 NSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQW---EFDDT 767
Query: 1208 TRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSV 1267
T + + G++ T+YS+ V AYT GDG RS + T VPG P + + ++
Sbjct: 768 TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPR-LVINHTQMNTA 826
Query: 1268 VVSWLPPTKPNGVIRKYTIFCSSPGSGQPAP-SEYETSPEQLFYRIAHLNRGQQYLLWVA 1326
++ W PP G ++ Y + G P + E S ++ + +++G Y+ ++
Sbjct: 827 LIQWHPPVDTFGPLQGYRL---KFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLS 883
Query: 1327 AVTSAGRGNSSEK---VTIEPAGKAPAKIISFGGTVTT---PWMKDVRLPCNSVGDPAPA 1380
A G G K + E P + S G T T+ W V N +
Sbjct: 884 ARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGI-----I 938
Query: 1381 VKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAE---DSGYYTCTATNTGGFDTIIVN 1437
K+T D IP+ ++ + T+ L +K + D T+ G + +
Sbjct: 939 TKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSV-- 996
Query: 1438 LLVQVPPDQ---PRLTVSKTSASSITLTWIPGDNGGSSI 1473
+P DQ V +S+ L+W +N S++
Sbjct: 997 QFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAM 1035
Score = 150 bits (380), Expect = 1e-35
Identities = 215/926 (23%), Positives = 360/926 (38%), Gaps = 107/926 (11%)
Query: 749 PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPL-TGRIQIL 807
PPRF P +Q G+ G C G P PK++W + Q++ + G +L
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVL 82
Query: 808 PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTV----KIP---AMITSHPNTTIA 860
L D Y C ASN VG +IS S LTV +IP I P +
Sbjct: 83 RIQPLR----TPRDEAIYECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQLKVV 137
Query: 861 IKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEV----VSTLKLKP 916
+ + C A G I W K +D T +N + L+++
Sbjct: 138 ERTRTATMLCAASGNPDPEITWFKDFLPVD----------TSNNNGRIKQLRSGALQIEQ 187
Query: 917 ADRGDSVFFSCHAINSYGEDRGL-IQLTVQEPPDPPELEIREVKARSMNLRWTQRFDGNS 975
++ D + C A NS G L V+ PP I M G+
Sbjct: 188 SEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMP-------GGSV 240
Query: 976 IITGFDIEYKNKSDSWDFKQSTRNISPTINQ---ANIVDLHPA-SVYSIRMYSFNKIGRS 1031
IT + W +++P + N+++L+ + + + +G
Sbjct: 241 NITCVAVGSPMPYVKW--MLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVI 298
Query: 1032 EPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSP 1091
E ++T+ +A P PP + T+ SI +TW + E + Y I ++ +
Sbjct: 299 EAIAQITV---KALPK-PPGTPVVTESTATSITLTWDSGNPE----PVSYYIIQHKPKN- 349
Query: 1092 GSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPS 1151
S Y ++ AT Y++ L ++ Y V A N G GP S + T E PS
Sbjct: 350 -SEELYKEIDGVAT---TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPS 405
Query: 1152 QPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRER 1211
P +V+A ++S ++ W EP NG ++GYRV + M++ +
Sbjct: 406 SAPRDVQARMLSSTTILVQWKEPEEP--NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQI 463
Query: 1212 VELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSW 1271
+ + YSV+VLA+T GDG SS + + T+ VPG P KA P S +S+++SW
Sbjct: 464 TTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSW 523
Query: 1272 LPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSA 1331
PP + I Y + G+ + T YR+ L Y +AA +
Sbjct: 524 TPPR--SDTIANYELVYK---DGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQ 578
Query: 1332 GRGNSSEKV---TIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE 1388
G G S+ ++ T++ AP + IS T+P + + P P K
Sbjct: 579 GLGASTAEISARTMQSKPSAPPQDIS----CTSPSSTSILVS----WQPPPVEKQNGIIT 630
Query: 1389 DSAIP-VSMDG-----HRLI---HTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLL 1439
+ +I ++DG H ++ LL ++ T TA G +++L
Sbjct: 631 EYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVL 690
Query: 1440 VQVPPDQP-----RLTVSKTSASSITLTW---IPGDNGGSSIRGFVLQY-SVDNSEE--- 1487
++ D P ++ V +++S+ ++W +P G IRG+ + Y ++N E
Sbjct: 691 IRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHG-QIRGYQVHYVRMENGEPKGQ 749
Query: 1488 --WKDVFISSSERSFK--------LDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGR 1537
KDV ++ ++ F + L+ T Y + + A + G G S+ T G
Sbjct: 750 PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 809
Query: 1538 EPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVF 1597
P K + + H A + + P+ L++ K L + + F
Sbjct: 810 VP--GKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHF 867
Query: 1598 -LTELREATWYELRMRACNSAGCGNE 1622
T++ + Y R+ A N G G E
Sbjct: 868 TATDIHKGASYVFRLSARNKVGFGEE 893
Score = 68.9 bits (167), Expect = 5e-11
Identities = 87/408 (21%), Positives = 143/408 (35%), Gaps = 48/408 (11%)
Query: 177 IRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFI 236
+R A +T DQ + G VA F C + + W K + + I
Sbjct: 16 LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIV---WNKKGKKVSNQRFEVI 72
Query: 237 TYHGG----LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGF 292
+ G L I ++ + Y C+ + + + L PTI G
Sbjct: 73 EFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGP 132
Query: 293 HSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTK----RITGLTISDLRTED 348
+ V T + C ASG P P I W KD P+ + + R L I D
Sbjct: 133 QLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESD 192
Query: 349 SGTYICEVTNTFGSAEATGILMVID----PLHVTLTPKKLKTGIGSTVILSCALTGSPEF 404
G Y C TN+ G+ + + + P ++ P + G +V ++C GSP
Sbjct: 193 QGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMP 252
Query: 405 TIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALE 464
++W E + P++ + I L + ++S + Y C A + A I ++
Sbjct: 253 YVKWMLGAEDLTPEDDMPI---GRNVLELNDVRQSAN--YTCVAMSTLGVIEAIAQITVK 307
Query: 465 -----DGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQY 519
GTP + S + + + G P P + + +P + Y
Sbjct: 308 ALPKPPGTPVVTESTATSIT--------LTWDSGNPEPVSYYIIQHKP-----KNSEELY 354
Query: 520 TMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS 567
DG + +V G +R A N +G RGPPS
Sbjct: 355 KEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIG----------RGPPS 392
Score = 60.1 bits (144), Expect = 2e-08
Identities = 86/333 (25%), Positives = 117/333 (35%), Gaps = 41/333 (12%)
Query: 374 PLHVTLTPKKLKTGI-GSTVILSCALTGSPEFTIRWYRNTELVLPD--EAISIRGLSNET 430
P T TP +TG+ G C TG P I W + + V E I S
Sbjct: 23 PPRFTRTPVD-QTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSV 81
Query: 431 LLITSAQKSHSGA-YQCFATRKAQ--TAQDFAIIALED----GTPRIVSSFSEKVVNPGE 483
L I + A Y+C A+ + + ED G P I KVV
Sbjct: 82 LRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTR 141
Query: 484 QFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVY 543
+++CAA G P P +TW D P+ ++ + S I + D G Y
Sbjct: 142 TATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEES-----DQGKY 196
Query: 544 RCTARNLVGSAEYQARINV-----RGPPSIR-AMRNITAVAGRDTLINCRVIGYPYYSIK 597
C A N G+ Y A N+ R PP N + G I C +G P +K
Sbjct: 197 ECVATNSAGT-RYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVK 255
Query: 598 WYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPP 657
W A L + N L+L DV++ Y C V + I + VK P
Sbjct: 256 WMLGAEDLTPEDDMPIGRN-VLELNDVRQ---SANYTC-VAMSTLGVIEAIAQITVKALP 310
Query: 658 LIQPFEFPPASIGQLLYIPCVVSSGDMPIRITW 690
PP + P V S I +TW
Sbjct: 311 K------PPGT-------PVVTESTATSITLTW 330
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 234 bits (597), Expect = 7e-61
Identities = 219/861 (25%), Positives = 358/861 (41%), Gaps = 88/861 (10%)
Query: 464 EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH-RTNQYTMS 522
ED PRIV S+ +V+ GE +L C A+G P PT+ W E + D R+++ +
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
Query: 523 DGTTISHMNVTGPQIR-DGGVYRCTARNLVGSA-EYQARINV-------RGPPSIRAMRN 573
G+ V G + R D GVY C ARN +G A + A + V R PS +
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-----D 139
Query: 574 ITAVAGRDTLINCRVI-GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632
+ G ++ C+ G+P +I W KD L D ++ G L +T +K D G+
Sbjct: 140 VMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS-DAGK 198
Query: 633 YLCSVLIQPQLSISQSVHVAV-KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWR 691
Y+C S+ + V + P ++ ++ C +P + WR
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT-VRWR 257
Query: 692 KD-GQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV-- 748
KD G++ S + + +L+I V+ G+YTC+A N L V+V
Sbjct: 258 KDDGELPKSRYEIRDDH-----TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 749 -PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQIL 807
PP FVV+P +Q G+ C G P P + W+ Y P + R +
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 808 PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI-----PAMITSHP-NTTIAI 861
L I +V D+GYY+CQ N G+ I+K+ + P +I P N T+A+
Sbjct: 373 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 432
Query: 862 KGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGD 921
G L+C A G I W K ++ I +NG L+++ A GD
Sbjct: 433 DG-TFVLSCVATGSPVPTILWRKDGVLVS---TQDSRIKQLENG-----VLQIRYAKLGD 483
Query: 922 SVFFSCHAINSYGEDRGLIQLTVQE----------------PPDPPELEIREVKARSMNL 965
+ ++C A GE + VQE P P + E+ +V ++ L
Sbjct: 484 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 543
Query: 966 RWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSF 1025
W + + T + IE + + ++ N+ + I L P ++Y + +
Sbjct: 544 SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVK--TETSAIKGLKPNAIYLFLVRAA 601
Query: 1026 NKIGRSEPSK-ELTISTEEAAPDGPPMD---------------VTLQPVTSQSIQVTWKA 1069
N G S+PS+ + T++ P +D ++S SI+V W
Sbjct: 602 NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV 661
Query: 1070 PKKELQNGVIRGYQIGYRENSPG-SNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQA 1128
+ Q+ I+GY+I YR + + + E++ + V + +L+K Y + +
Sbjct: 662 ---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIKARP 717
Query: 1129 FNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSD--VAVISWSEPPRSTLNGVLKGY 1186
F G S A TLE+ PS PP+ V + ++SW PP T NG+++ Y
Sbjct: 718 FFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY 777
Query: 1187 RVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQT 1246
+V W L + + + + + V + + YSV+V A T AG GV+S +IQ
Sbjct: 778 KV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 835
Query: 1247 KEDVPGPPAGIKAVPSSASSV 1267
D G P + S A +
Sbjct: 836 --DAHGNPVSPEDQVSLAQQI 854
Score = 139 bits (349), Expect = 4e-32
Identities = 144/491 (29%), Positives = 204/491 (41%), Gaps = 71/491 (14%)
Query: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP--------------LPADSR 331
P I++ V G L C A G P P I W K G LP+ S
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 332 WTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH--VTLTPKKLKTGIG 389
+ RI S D G Y+C N G A + + + L P + +G
Sbjct: 89 FFLRIVHGRKS---RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
Query: 390 STVILSC-ALTGSPEFTIRWYRN-TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCF 447
++ C G PE TI W ++ + L DE I+IRG L+IT +KS +G Y C
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG---GKLMITYTRKSDAGKYVCV 202
Query: 448 AT-----RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
T R+++ A+ + LE P V S V + C A+G P PTV W
Sbjct: 203 GTNMVGERESEVAE---LTVLE--RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562
D DG ++Y + D T+ VT D G Y C A N+VG AE A + V
Sbjct: 258 KD------DGELPKSRYEIRDDHTLKIRKVTA---GDMGSYTCVAENMVGKAEASATLTV 308
Query: 563 R----GPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA---LLL-----PDNHR 610
+ P + R+ GR C G P +I W ++ LL + R
Sbjct: 309 QVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 368
Query: 611 QVVFENGTLKLTDVQKGMDEGEYLC-------SVLIQPQLSISQSVHVAVKVPPLIQ--P 661
V + G L +T+VQ+ D G Y+C S++ + L ++ +A + PP+I+ P
Sbjct: 369 FSVSQTGDLTITNVQRS-DVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGP 425
Query: 662 FEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSL 721
A G + + CV + +P I WRKDG V++S I+ E LQI L
Sbjct: 426 VNQTVAVDGTFV-LSCVATGSPVP-TILWRKDG-VLVSTQDSRIKQLE-NGVLQIRYAKL 481
Query: 722 KHNGNYTCIAS 732
G YTCIAS
Sbjct: 482 GDTGRYTCIAS 492
Score = 136 bits (342), Expect = 2e-31
Identities = 224/994 (22%), Positives = 367/994 (36%), Gaps = 130/994 (13%)
Query: 374 PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDE------AISIRGLS 427
P + P L G L+C G P TI WY+ E V D+ + + S
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 428 NETLLITSAQKSH--SGAYQCFATRKAQTA----QDFAIIALEDGTPRIVSSFSEKVVNP 481
L I +KS G Y C A A + L D + S+ +V
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD---FRQNPSDVMVAV 144
Query: 482 GEQFSLMC-AAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDG 540
GE + C +G P PT++W D P+ + + T+ G + +T + D
Sbjct: 145 GEPAVMECQPPRGHPEPTISWKKDGSPL----DDKDERITIRGG----KLMITYTRKSDA 196
Query: 541 GVYRCTARNLVGSAEYQ-ARINVRGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKW 598
G Y C N+VG E + A + V PS ++ N+ C G P +++W
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 599 YKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC---SVLIQPQLSISQSVHVAVKV 655
KD LP + R + ++ TLK+ V G D G Y C +++ + + S + +V V +
Sbjct: 257 RKDDGELPKS-RYEIRDDHTLKIRKVTAG-DMGSYTCVAENMVGKAEASATLTVQVGSEP 314
Query: 656 PPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMS--- 712
P + ++G+ + C + P I WR++G + S +S S
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
Query: 713 --SLQISSVSLKHNGNYTCIASNAAATVSRERQLIV------RVPPRFVVQPNNQDGIYG 764
L I++V G Y C N A ++ + L V R PP P NQ
Sbjct: 374 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 765 KAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGY 824
VL+C G P P ++W+ + Q RI+ L N L IR+ D G
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQD-------SRIKQLENGVLQIRYAKLGDTGR 486
Query: 825 YLCQASNGVGTDISKSMFLTVK---IPAMITSHPNTTIAIKGHAKELNCTARGERPIIIR 881
Y C AS G + + S ++ V+ +P P I + T + +
Sbjct: 487 YTCIASTPSG-EATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 544
Query: 882 WEKG-DTVIDPDR--VMRYAIATKDNGDEVVSTLK-----LKPADRGDSVFFSCHAINSY 933
W+ ++ P + ++ A+ + V +K +K F A N+Y
Sbjct: 545 WQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY 604
Query: 934 G------------------EDRGLIQLTVQEPPDPPELEIRE---VKARSMNLRWTQRFD 972
G +G+ VQ L + + + S+ + WT
Sbjct: 605 GISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-Q 663
Query: 973 GNSIITGFDIEYK------NKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFN 1026
+ I G+ I Y+ +SD F+ T P N I DL Y I+ F
Sbjct: 664 QSQYIQGYKILYRPSGANHGESDWLVFEVRT----PAKNSVVIPDLRKGVNYEIKARPFF 719
Query: 1027 KIGRSEPSKELTISTEEAAPDGPPMDVTL--QPVTSQSIQVTWKAPKKELQNGVIRGYQI 1084
+ S+ T E AP PP VT+ +I V+W+ P ++ QNG+++ Y++
Sbjct: 720 NEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 779
Query: 1085 GYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINA 1143
G+ +Y I G + + L +Y V V A AG+G S +
Sbjct: 780 W----CLGNETRYHI-NKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQ 834
Query: 1144 TTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQ 1203
P P + V SDV +P G ++ +S+++ +
Sbjct: 835 LDAHGNPVSPEDQVSLAQQISDVV----KQPAFIAGIGAACWIILMVFSIWLYRHRKKRN 890
Query: 1204 NITTTRERVELRGMEKFTNYS-VQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPS 1262
+T+T G+ K +++ + Y + G+ V S G G+ +
Sbjct: 891 GLTST-----YAGIRKVPSFTFTPTVTYQRGGEAVSS------------GGRPGLLNISE 933
Query: 1263 SASSVVVSWLPPTKPN--GVIRKYTIFCSSPGSG 1294
A+ WL T PN +I C + G+G
Sbjct: 934 PAAQ---PWLADTWPNTGNNHNDCSISCCTAGNG 964
Score = 129 bits (323), Expect = 4e-29
Identities = 186/836 (22%), Positives = 323/836 (38%), Gaps = 115/836 (13%)
Query: 579 GRDTLINCRVIGYPYYSIKWYKDALLL------PDNHRQVVFENGTLKLTDVQKGM---- 628
G +NC+ G P +I+WYK + P +HR ++ +G+L + G
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL-PSGSLFFLRIVHGRKSRP 101
Query: 629 DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPA----SIGQLLYIPCVVSSGDM 684
DEG Y+C + + L + S + +++V L F P+ ++G+ + C G
Sbjct: 102 DEGVYVC--VARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHP 159
Query: 685 PIRITWRKDGQVIIS-GSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRE-R 742
I+W+KDG + +TI + M I+ G Y C+ +N E
Sbjct: 160 EPTISWKKDGSPLDDKDERITIRGGKLM----ITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 743 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
+L V P FV +P+N + C G P P V W+ G +Y
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY------- 268
Query: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI---PAMITSHPNTTI 859
+I + +L IR V D+G Y C A N VG S LTV++ P P +
Sbjct: 269 --EIRDDHTLKIRKVTAGDMGSYTCVAENMVGK-AEASATLTVQVGSEPPHFVVKPRDQV 325
Query: 860 AIKGHAKELNCTARGERPIIIRWEKGDT------VIDPDRVMRYAIATKDNGDEVVSTLK 913
G C A G I W + + P R++++ GD ++ ++
Sbjct: 326 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS--QTGDLTITNVQ 383
Query: 914 LKPADRGDSVFFSCHAINSYGE--DRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRF 971
R D ++ C +N G + +++T PP + R + T
Sbjct: 384 -----RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV------IRQGPVNQTVAV 432
Query: 972 DGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGR- 1030
DG +++ + W + + + I L V IR GR
Sbjct: 433 DGTFVLSCVATGSPVPTILW----RKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRY 487
Query: 1031 ----SEPSKELTIST-----EEAAPDGPPM--DVTLQP----------VTSQSIQVTWKA 1069
S PS E T S E P PP D L P V+ ++ ++W+
Sbjct: 488 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP 547
Query: 1070 PKKELQNGVI-RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQA 1128
L +G Y I ++ GS+ Q +K +E + LK A Y +V+A
Sbjct: 548 ---NLNSGATPTSYIIEAFSHASGSSWQTVAENVK----TETSAIKGLKPNAIYLFLVRA 600
Query: 1129 FNRAGTGPSSSEINATTLEDV-PSQPPENVRALSITSDVAVISWSEPPRSTLNGV----- 1182
N G S + +DV P+ + + + AV+ P + + +
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 1183 -------LKGYRVIF---WSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQ 1232
++GY++++ + + + +W + T + V + + K NY ++ +
Sbjct: 661 VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720
Query: 1233 AGDGVRSSVLYIQTKEDVPG-PPAGIKAVPS--SASSVVVSWLPPTKP--NGVIRKYTIF 1287
G S + + +T E+ P PP G+ + + ++++VSW PP + NG++++Y ++
Sbjct: 721 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780
Query: 1288 CSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIE 1343
C + + S + I L G +Y + VAA T AG G SE I+
Sbjct: 781 CLGNETRYHINKTVDGSTFSVV--IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQ 834
Score = 126 bits (317), Expect = 2e-28
Identities = 133/480 (27%), Positives = 193/480 (40%), Gaps = 45/480 (9%)
Query: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIH-------DN 159
C A G P+ + WY G+ + H L P F +H +
Sbjct: 50 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHR----MLLPSGSLFFLRIVHGRKSRPDEG 104
Query: 160 DYFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218
Y C A N G+ S N ++ A+ R+ + D G AV +C P E
Sbjct: 105 VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE--PT 162
Query: 219 VSWEKDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
+SW+KD S + + IT GG L I+ +K DA Y C+ + GE R+S A L+
Sbjct: 163 ISWKKDG-SPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTNMV-GE-RESEVAELT 218
Query: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337
V + P+ + + V + E C A G P+P +RW KD LP +
Sbjct: 219 VLER----PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH 274
Query: 338 GLTISDLRTEDSGTYICEVTNTFGSAEATGILMV---IDPLHVTLTPKKLKTGIGSTVIL 394
L I + D G+Y C N G AEA+ L V +P H + P+ +G TV
Sbjct: 275 TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334
Query: 395 SCALTGSPEFTIRWYRNTELVL-----PDEAISIRGLSNE-TLLITSAQKSHSGAYQCFA 448
C TG+P+ I W R L P ++ S +S L IT+ Q+S G Y C
Sbjct: 335 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQT 394
Query: 449 TRKAQTAQDFAIIALED-----GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWAL 503
A + A + + D P I + V F L C A G+P PT+ W
Sbjct: 395 LNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR- 453
Query: 504 DDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR 563
D +V R Q + +G + + ++ D G Y C A G A + A I V+
Sbjct: 454 KDGVLVSTQDSRIKQ--LENGV----LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Score = 99.4 bits (246), Expect = 3e-20
Identities = 93/324 (28%), Positives = 140/324 (43%), Gaps = 26/324 (8%)
Query: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 220
Y C N G+ S + + R + R + + A FKC + + V V
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKC---EARGDPVPTVR 255
Query: 221 WEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD 280
W KD + P+ R+ I L I V D + +Y C+ ++ + A L+V
Sbjct: 256 WRKDDGEL-PKSRYEIRDDHTLKIRKVTAGD-MGSYTCVAENMVG---KAEASATLTVQV 310
Query: 281 PAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDG--------RPLPADSRW 332
+E P + Q V G TV C A+G P PAI W ++G +P + SR+
Sbjct: 311 GSEP-PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 333 TKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVID------PLHVTLTPKKLK 385
+ TG LTI++++ D G YIC+ N GS L V D P + P
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 386 TGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 445
+ T +LSC TGSP TI W ++ LV ++ I+ L N L I A+ +G Y
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYT 488
Query: 446 CFATRKAQTAQDFAIIALED-GTP 468
C A+ + A A I +++ G P
Sbjct: 489 CIASTPSGEATWSAYIEVQEFGVP 512
Score = 69.3 bits (168), Expect = 4e-11
Identities = 76/310 (24%), Positives = 121/310 (39%), Gaps = 44/310 (14%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT-NGTLLLRAVKAEDSGYYTCTATN 1427
L C + G P P + W KD + VS R+ NG L +R K D+G YTC A+
Sbjct: 438 LSCVATGSPVPTILWRKDG----VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 1428 TGGFDTIIVNLLVQ---VPPDQPRLT-------------VSKTSASSITLTWIPGDNGGS 1471
G T + VQ VP PR T V+ S +++TL+W P N G+
Sbjct: 494 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 553
Query: 1472 SIRGFVLQ-YSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEII 1530
+ ++++ +S + W+ V + + + LK Y + A N+ G S+I
Sbjct: 554 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 613
Query: 1531 E-AKTHGREPSFSKDQHLFTHINSTHARLNLQG------------W--NNGGCPITAIVL 1575
+ KT P+ H +A L+L W + I +
Sbjct: 614 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 673
Query: 1576 EYRPKGT------WAWQGLRANSSGEVFLTELREATWYELRMRA-CNSAGCGNETAQFAT 1628
YRP G W +R + V + +LR+ YE++ R N + +FA
Sbjct: 674 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 733
Query: 1629 LDYDGSTIPP 1638
+ + PP
Sbjct: 734 TLEEAPSAPP 743
Score = 51.2 bits (121), Expect = 1e-05
Identities = 33/81 (40%), Positives = 38/81 (46%), Gaps = 5/81 (6%)
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
C + GDP P V+W KD D +P S R HT L +R V A D G YTC A N G
Sbjct: 244 CEARGDPVPTVRWRKD--DGELPKSRYEIRDDHT---LKIRKVTAGDMGSYTCVAENMVG 298
Query: 1431 FDTIIVNLLVQVPPDQPRLTV 1451
L VQV + P V
Sbjct: 299 KAEASATLTVQVGSEPPHFVV 319
Score = 47.4 bits (111), Expect = 2e-04
Identities = 72/362 (19%), Positives = 128/362 (35%), Gaps = 54/362 (14%)
Query: 1294 GQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPA--- 1350
G+ S YE + +I + G A G+ +S +T++ + P
Sbjct: 261 GELPKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 1351 ----KIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAI----PVSMDGHRLI 1402
++++ G TVT C + G+P PA+ W ++ + + P +
Sbjct: 320 KPRDQVVALGRTVT--------FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 371
Query: 1403 HTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP---PDQPRLTVSKTSASSI 1459
G L + V+ D GYY C N G +II ++V D+P + + +
Sbjct: 372 SQTGDLTITNVQRSDVGYYICQTLNVAG--SIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 1460 TLTWIPGDNGGSSIRGFVLQYSVDNSEEWK--DVFISSSERSFK--------LDSLKCGT 1509
G+ + V S + W+ V +S+ + K + K G
Sbjct: 430 VAV------DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGD 483
Query: 1510 WYKVKLAAKNSVGSGRISEIIEAKTHG--REPSFSKDQHLF---------THINSTHARL 1558
+ A G S IE + G +P D +L T ++ L
Sbjct: 484 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 543
Query: 1559 NLQ-GWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEV-FLTELREATWYELRMRACNS 1616
+ Q N+G P + I+ + +WQ + N E + L+ Y +RA N+
Sbjct: 544 SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANA 603
Query: 1617 AG 1618
G
Sbjct: 604 YG 605
Score = 40.4 bits (93), Expect = 0.019
Identities = 36/171 (21%), Positives = 62/171 (36%), Gaps = 14/171 (8%)
Query: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATN-TGGFDT 1433
G P P + W KD P+ R+ G L++ + D+G Y C TN G ++
Sbjct: 157 GHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
Query: 1434 IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGF---VLQYSVDNSEEWKD 1490
+ L V P + S++ +T RG +++ D+ E K
Sbjct: 213 EVAELTVLERPSFVK------RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 1491 VFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSF 1541
+ + + K+ + G A+N VG S + + P F
Sbjct: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Score = 34.7 bits (78), Expect = 1.0
Identities = 26/88 (29%), Positives = 37/88 (42%), Gaps = 12/88 (13%)
Query: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE----DSAIPVSMDGHRLIHT 1404
P +I+ + + L C + G P P ++W K E D P S HR++
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLP 84
Query: 1405 NGTL-LLRAVKAE----DSGYYTCTATN 1427
+G+L LR V D G Y C A N
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARN 112
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 234 bits (597), Expect = 7e-61
Identities = 219/861 (25%), Positives = 358/861 (41%), Gaps = 88/861 (10%)
Query: 464 EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH-RTNQYTMS 522
ED PRIV S+ +V+ GE +L C A+G P PT+ W E + D R+++ +
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
Query: 523 DGTTISHMNVTGPQIR-DGGVYRCTARNLVGSA-EYQARINV-------RGPPSIRAMRN 573
G+ V G + R D GVY C ARN +G A + A + V R PS +
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-----D 139
Query: 574 ITAVAGRDTLINCRVI-GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632
+ G ++ C+ G+P +I W KD L D ++ G L +T +K D G+
Sbjct: 140 VMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS-DAGK 198
Query: 633 YLCSVLIQPQLSISQSVHVAV-KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWR 691
Y+C S+ + V + P ++ ++ C +P + WR
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT-VRWR 257
Query: 692 KD-GQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV-- 748
KD G++ S + + +L+I V+ G+YTC+A N L V+V
Sbjct: 258 KDDGELPKSRYEIRDDH-----TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 749 -PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQIL 807
PP FVV+P +Q G+ C G P P + W+ Y P + R +
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 808 PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI-----PAMITSHP-NTTIAI 861
L I +V D+GYY+CQ N G+ I+K+ + P +I P N T+A+
Sbjct: 373 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 432
Query: 862 KGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGD 921
G L+C A G I W K ++ I +NG L+++ A GD
Sbjct: 433 DG-TFVLSCVATGSPVPTILWRKDGVLVS---TQDSRIKQLENG-----VLQIRYAKLGD 483
Query: 922 SVFFSCHAINSYGEDRGLIQLTVQE----------------PPDPPELEIREVKARSMNL 965
+ ++C A GE + VQE P P + E+ +V ++ L
Sbjct: 484 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 543
Query: 966 RWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSF 1025
W + + T + IE + + ++ N+ + I L P ++Y + +
Sbjct: 544 SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVK--TETSAIKGLKPNAIYLFLVRAA 601
Query: 1026 NKIGRSEPSK-ELTISTEEAAPDGPPMD---------------VTLQPVTSQSIQVTWKA 1069
N G S+PS+ + T++ P +D ++S SI+V W
Sbjct: 602 NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV 661
Query: 1070 PKKELQNGVIRGYQIGYRENSPG-SNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQA 1128
+ Q+ I+GY+I YR + + + E++ + V + +L+K Y + +
Sbjct: 662 ---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIKARP 717
Query: 1129 FNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSD--VAVISWSEPPRSTLNGVLKGY 1186
F G S A TLE+ PS PP+ V + ++SW PP T NG+++ Y
Sbjct: 718 FFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY 777
Query: 1187 RVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQT 1246
+V W L + + + + + V + + YSV+V A T AG GV+S +IQ
Sbjct: 778 KV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 835
Query: 1247 KEDVPGPPAGIKAVPSSASSV 1267
D G P + S A +
Sbjct: 836 --DAHGNPVSPEDQVSLAQQI 854
Score = 139 bits (349), Expect = 4e-32
Identities = 144/491 (29%), Positives = 204/491 (41%), Gaps = 71/491 (14%)
Query: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP--------------LPADSR 331
P I++ V G L C A G P P I W K G LP+ S
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 332 WTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH--VTLTPKKLKTGIG 389
+ RI S D G Y+C N G A + + + L P + +G
Sbjct: 89 FFLRIVHGRKS---RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
Query: 390 STVILSC-ALTGSPEFTIRWYRN-TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCF 447
++ C G PE TI W ++ + L DE I+IRG L+IT +KS +G Y C
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG---GKLMITYTRKSDAGKYVCV 202
Query: 448 AT-----RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
T R+++ A+ + LE P V S V + C A+G P PTV W
Sbjct: 203 GTNMVGERESEVAE---LTVLE--RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562
D DG ++Y + D T+ VT D G Y C A N+VG AE A + V
Sbjct: 258 KD------DGELPKSRYEIRDDHTLKIRKVTA---GDMGSYTCVAENMVGKAEASATLTV 308
Query: 563 R----GPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA---LLL-----PDNHR 610
+ P + R+ GR C G P +I W ++ LL + R
Sbjct: 309 QVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 368
Query: 611 QVVFENGTLKLTDVQKGMDEGEYLC-------SVLIQPQLSISQSVHVAVKVPPLIQ--P 661
V + G L +T+VQ+ D G Y+C S++ + L ++ +A + PP+I+ P
Sbjct: 369 FSVSQTGDLTITNVQRS-DVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGP 425
Query: 662 FEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSL 721
A G + + CV + +P I WRKDG V++S I+ E LQI L
Sbjct: 426 VNQTVAVDGTFV-LSCVATGSPVP-TILWRKDG-VLVSTQDSRIKQLE-NGVLQIRYAKL 481
Query: 722 KHNGNYTCIAS 732
G YTCIAS
Sbjct: 482 GDTGRYTCIAS 492
Score = 136 bits (342), Expect = 2e-31
Identities = 224/994 (22%), Positives = 367/994 (36%), Gaps = 130/994 (13%)
Query: 374 PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDE------AISIRGLS 427
P + P L G L+C G P TI WY+ E V D+ + + S
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 428 NETLLITSAQKSH--SGAYQCFATRKAQTA----QDFAIIALEDGTPRIVSSFSEKVVNP 481
L I +KS G Y C A A + L D + S+ +V
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD---FRQNPSDVMVAV 144
Query: 482 GEQFSLMC-AAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDG 540
GE + C +G P PT++W D P+ + + T+ G + +T + D
Sbjct: 145 GEPAVMECQPPRGHPEPTISWKKDGSPL----DDKDERITIRGG----KLMITYTRKSDA 196
Query: 541 GVYRCTARNLVGSAEYQ-ARINVRGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKW 598
G Y C N+VG E + A + V PS ++ N+ C G P +++W
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 599 YKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC---SVLIQPQLSISQSVHVAVKV 655
KD LP + R + ++ TLK+ V G D G Y C +++ + + S + +V V +
Sbjct: 257 RKDDGELPKS-RYEIRDDHTLKIRKVTAG-DMGSYTCVAENMVGKAEASATLTVQVGSEP 314
Query: 656 PPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMS--- 712
P + ++G+ + C + P I WR++G + S +S S
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
Query: 713 --SLQISSVSLKHNGNYTCIASNAAATVSRERQLIV------RVPPRFVVQPNNQDGIYG 764
L I++V G Y C N A ++ + L V R PP P NQ
Sbjct: 374 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 765 KAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGY 824
VL+C G P P ++W+ + Q RI+ L N L IR+ D G
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQD-------SRIKQLENGVLQIRYAKLGDTGR 486
Query: 825 YLCQASNGVGTDISKSMFLTVK---IPAMITSHPNTTIAIKGHAKELNCTARGERPIIIR 881
Y C AS G + + S ++ V+ +P P I + T + +
Sbjct: 487 YTCIASTPSG-EATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 544
Query: 882 WEKG-DTVIDPDR--VMRYAIATKDNGDEVVSTLK-----LKPADRGDSVFFSCHAINSY 933
W+ ++ P + ++ A+ + V +K +K F A N+Y
Sbjct: 545 WQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY 604
Query: 934 G------------------EDRGLIQLTVQEPPDPPELEIRE---VKARSMNLRWTQRFD 972
G +G+ VQ L + + + S+ + WT
Sbjct: 605 GISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-Q 663
Query: 973 GNSIITGFDIEYK------NKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFN 1026
+ I G+ I Y+ +SD F+ T P N I DL Y I+ F
Sbjct: 664 QSQYIQGYKILYRPSGANHGESDWLVFEVRT----PAKNSVVIPDLRKGVNYEIKARPFF 719
Query: 1027 KIGRSEPSKELTISTEEAAPDGPPMDVTL--QPVTSQSIQVTWKAPKKELQNGVIRGYQI 1084
+ S+ T E AP PP VT+ +I V+W+ P ++ QNG+++ Y++
Sbjct: 720 NEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 779
Query: 1085 GYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINA 1143
G+ +Y I G + + L +Y V V A AG+G S +
Sbjct: 780 W----CLGNETRYHI-NKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQ 834
Query: 1144 TTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQ 1203
P P + V SDV +P G ++ +S+++ +
Sbjct: 835 LDAHGNPVSPEDQVSLAQQISDVV----KQPAFIAGIGAACWIILMVFSIWLYRHRKKRN 890
Query: 1204 NITTTRERVELRGMEKFTNYS-VQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPS 1262
+T+T G+ K +++ + Y + G+ V S G G+ +
Sbjct: 891 GLTST-----YAGIRKVPSFTFTPTVTYQRGGEAVSS------------GGRPGLLNISE 933
Query: 1263 SASSVVVSWLPPTKPN--GVIRKYTIFCSSPGSG 1294
A+ WL T PN +I C + G+G
Sbjct: 934 PAAQ---PWLADTWPNTGNNHNDCSISCCTAGNG 964
Score = 129 bits (323), Expect = 4e-29
Identities = 186/836 (22%), Positives = 323/836 (38%), Gaps = 115/836 (13%)
Query: 579 GRDTLINCRVIGYPYYSIKWYKDALLL------PDNHRQVVFENGTLKLTDVQKGM---- 628
G +NC+ G P +I+WYK + P +HR ++ +G+L + G
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL-PSGSLFFLRIVHGRKSRP 101
Query: 629 DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPA----SIGQLLYIPCVVSSGDM 684
DEG Y+C + + L + S + +++V L F P+ ++G+ + C G
Sbjct: 102 DEGVYVC--VARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHP 159
Query: 685 PIRITWRKDGQVIIS-GSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRE-R 742
I+W+KDG + +TI + M I+ G Y C+ +N E
Sbjct: 160 EPTISWKKDGSPLDDKDERITIRGGKLM----ITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 743 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
+L V P FV +P+N + C G P P V W+ G +Y
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY------- 268
Query: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI---PAMITSHPNTTI 859
+I + +L IR V D+G Y C A N VG S LTV++ P P +
Sbjct: 269 --EIRDDHTLKIRKVTAGDMGSYTCVAENMVGK-AEASATLTVQVGSEPPHFVVKPRDQV 325
Query: 860 AIKGHAKELNCTARGERPIIIRWEKGDT------VIDPDRVMRYAIATKDNGDEVVSTLK 913
G C A G I W + + P R++++ GD ++ ++
Sbjct: 326 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS--QTGDLTITNVQ 383
Query: 914 LKPADRGDSVFFSCHAINSYGE--DRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRF 971
R D ++ C +N G + +++T PP + R + T
Sbjct: 384 -----RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV------IRQGPVNQTVAV 432
Query: 972 DGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGR- 1030
DG +++ + W + + + I L V IR GR
Sbjct: 433 DGTFVLSCVATGSPVPTILW----RKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRY 487
Query: 1031 ----SEPSKELTIST-----EEAAPDGPPM--DVTLQP----------VTSQSIQVTWKA 1069
S PS E T S E P PP D L P V+ ++ ++W+
Sbjct: 488 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP 547
Query: 1070 PKKELQNGVI-RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQA 1128
L +G Y I ++ GS+ Q +K +E + LK A Y +V+A
Sbjct: 548 ---NLNSGATPTSYIIEAFSHASGSSWQTVAENVK----TETSAIKGLKPNAIYLFLVRA 600
Query: 1129 FNRAGTGPSSSEINATTLEDV-PSQPPENVRALSITSDVAVISWSEPPRSTLNGV----- 1182
N G S + +DV P+ + + + AV+ P + + +
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 1183 -------LKGYRVIF---WSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQ 1232
++GY++++ + + + +W + T + V + + K NY ++ +
Sbjct: 661 VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720
Query: 1233 AGDGVRSSVLYIQTKEDVPG-PPAGIKAVPS--SASSVVVSWLPPTKP--NGVIRKYTIF 1287
G S + + +T E+ P PP G+ + + ++++VSW PP + NG++++Y ++
Sbjct: 721 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780
Query: 1288 CSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIE 1343
C + + S + I L G +Y + VAA T AG G SE I+
Sbjct: 781 CLGNETRYHINKTVDGSTFSVV--IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQ 834
Score = 126 bits (317), Expect = 2e-28
Identities = 133/480 (27%), Positives = 193/480 (40%), Gaps = 45/480 (9%)
Query: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIH-------DN 159
C A G P+ + WY G+ + H L P F +H +
Sbjct: 50 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHR----MLLPSGSLFFLRIVHGRKSRPDEG 104
Query: 160 DYFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218
Y C A N G+ S N ++ A+ R+ + D G AV +C P E
Sbjct: 105 VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE--PT 162
Query: 219 VSWEKDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
+SW+KD S + + IT GG L I+ +K DA Y C+ + GE R+S A L+
Sbjct: 163 ISWKKDG-SPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTNMV-GE-RESEVAELT 218
Query: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337
V + P+ + + V + E C A G P+P +RW KD LP +
Sbjct: 219 VLER----PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH 274
Query: 338 GLTISDLRTEDSGTYICEVTNTFGSAEATGILMV---IDPLHVTLTPKKLKTGIGSTVIL 394
L I + D G+Y C N G AEA+ L V +P H + P+ +G TV
Sbjct: 275 TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334
Query: 395 SCALTGSPEFTIRWYRNTELVL-----PDEAISIRGLSNE-TLLITSAQKSHSGAYQCFA 448
C TG+P+ I W R L P ++ S +S L IT+ Q+S G Y C
Sbjct: 335 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQT 394
Query: 449 TRKAQTAQDFAIIALED-----GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWAL 503
A + A + + D P I + V F L C A G+P PT+ W
Sbjct: 395 LNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR- 453
Query: 504 DDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR 563
D +V R Q + +G + + ++ D G Y C A G A + A I V+
Sbjct: 454 KDGVLVSTQDSRIKQ--LENGV----LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Score = 99.4 bits (246), Expect = 3e-20
Identities = 93/324 (28%), Positives = 140/324 (43%), Gaps = 26/324 (8%)
Query: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 220
Y C N G+ S + + R + R + + A FKC + + V V
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKC---EARGDPVPTVR 255
Query: 221 WEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD 280
W KD + P+ R+ I L I V D + +Y C+ ++ + A L+V
Sbjct: 256 WRKDDGEL-PKSRYEIRDDHTLKIRKVTAGD-MGSYTCVAENMVG---KAEASATLTVQV 310
Query: 281 PAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDG--------RPLPADSRW 332
+E P + Q V G TV C A+G P PAI W ++G +P + SR+
Sbjct: 311 GSEP-PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 333 TKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVID------PLHVTLTPKKLK 385
+ TG LTI++++ D G YIC+ N GS L V D P + P
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 386 TGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 445
+ T +LSC TGSP TI W ++ LV ++ I+ L N L I A+ +G Y
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYT 488
Query: 446 CFATRKAQTAQDFAIIALED-GTP 468
C A+ + A A I +++ G P
Sbjct: 489 CIASTPSGEATWSAYIEVQEFGVP 512
Score = 69.3 bits (168), Expect = 4e-11
Identities = 76/310 (24%), Positives = 121/310 (39%), Gaps = 44/310 (14%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT-NGTLLLRAVKAEDSGYYTCTATN 1427
L C + G P P + W KD + VS R+ NG L +R K D+G YTC A+
Sbjct: 438 LSCVATGSPVPTILWRKDG----VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 1428 TGGFDTIIVNLLVQ---VPPDQPRLT-------------VSKTSASSITLTWIPGDNGGS 1471
G T + VQ VP PR T V+ S +++TL+W P N G+
Sbjct: 494 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 553
Query: 1472 SIRGFVLQ-YSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEII 1530
+ ++++ +S + W+ V + + + LK Y + A N+ G S+I
Sbjct: 554 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 613
Query: 1531 E-AKTHGREPSFSKDQHLFTHINSTHARLNLQG------------W--NNGGCPITAIVL 1575
+ KT P+ H +A L+L W + I +
Sbjct: 614 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 673
Query: 1576 EYRPKGT------WAWQGLRANSSGEVFLTELREATWYELRMRA-CNSAGCGNETAQFAT 1628
YRP G W +R + V + +LR+ YE++ R N + +FA
Sbjct: 674 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 733
Query: 1629 LDYDGSTIPP 1638
+ + PP
Sbjct: 734 TLEEAPSAPP 743
Score = 51.2 bits (121), Expect = 1e-05
Identities = 33/81 (40%), Positives = 38/81 (46%), Gaps = 5/81 (6%)
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
C + GDP P V+W KD D +P S R HT L +R V A D G YTC A N G
Sbjct: 244 CEARGDPVPTVRWRKD--DGELPKSRYEIRDDHT---LKIRKVTAGDMGSYTCVAENMVG 298
Query: 1431 FDTIIVNLLVQVPPDQPRLTV 1451
L VQV + P V
Sbjct: 299 KAEASATLTVQVGSEPPHFVV 319
Score = 47.4 bits (111), Expect = 2e-04
Identities = 72/362 (19%), Positives = 128/362 (35%), Gaps = 54/362 (14%)
Query: 1294 GQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPA--- 1350
G+ S YE + +I + G A G+ +S +T++ + P
Sbjct: 261 GELPKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 1351 ----KIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAI----PVSMDGHRLI 1402
++++ G TVT C + G+P PA+ W ++ + + P +
Sbjct: 320 KPRDQVVALGRTVT--------FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 371
Query: 1403 HTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP---PDQPRLTVSKTSASSI 1459
G L + V+ D GYY C N G +II ++V D+P + + +
Sbjct: 372 SQTGDLTITNVQRSDVGYYICQTLNVAG--SIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 1460 TLTWIPGDNGGSSIRGFVLQYSVDNSEEWK--DVFISSSERSFK--------LDSLKCGT 1509
G+ + V S + W+ V +S+ + K + K G
Sbjct: 430 VAV------DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGD 483
Query: 1510 WYKVKLAAKNSVGSGRISEIIEAKTHG--REPSFSKDQHLF---------THINSTHARL 1558
+ A G S IE + G +P D +L T ++ L
Sbjct: 484 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 543
Query: 1559 NLQ-GWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEV-FLTELREATWYELRMRACNS 1616
+ Q N+G P + I+ + +WQ + N E + L+ Y +RA N+
Sbjct: 544 SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANA 603
Query: 1617 AG 1618
G
Sbjct: 604 YG 605
Score = 40.4 bits (93), Expect = 0.019
Identities = 36/171 (21%), Positives = 62/171 (36%), Gaps = 14/171 (8%)
Query: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATN-TGGFDT 1433
G P P + W KD P+ R+ G L++ + D+G Y C TN G ++
Sbjct: 157 GHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
Query: 1434 IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGF---VLQYSVDNSEEWKD 1490
+ L V P + S++ +T RG +++ D+ E K
Sbjct: 213 EVAELTVLERPSFVK------RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 1491 VFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSF 1541
+ + + K+ + G A+N VG S + + P F
Sbjct: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Score = 34.7 bits (78), Expect = 1.0
Identities = 26/88 (29%), Positives = 37/88 (42%), Gaps = 12/88 (13%)
Query: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE----DSAIPVSMDGHRLIHT 1404
P +I+ + + L C + G P P ++W K E D P S HR++
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLP 84
Query: 1405 NGTL-LLRAVKAE----DSGYYTCTATN 1427
+G+L LR V D G Y C A N
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARN 112
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 232 bits (591), Expect = 3e-60
Identities = 225/835 (26%), Positives = 358/835 (42%), Gaps = 94/835 (11%)
Query: 464 EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRD-GSHRTNQYTMS 522
ED PRIV S+ +V+ GE +L C A+G P PT+ W D E + D R+++ +
Sbjct: 43 EDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 102
Query: 523 DGTTISHMNVTGPQIR-DGGVYRCTARNLVGSAEYQ--------ARINVRGPPSIRAMRN 573
G+ V G + + D G Y C ARN +G A + R + R P+ +
Sbjct: 103 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT-----D 157
Query: 574 ITAVAGRDTLINCR-VIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632
+ AG ++ C+ G+P +I W KD + + D ++ G L +++ +K D G
Sbjct: 158 VVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKS-DAGM 216
Query: 633 YLC--SVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITW 690
Y C + ++ + S + V + L +P + + C V GD + W
Sbjct: 217 YTCVGTNMVGERDSDPAELTVFERPTFLRRPIN-QVVLEEEAVEFRCQV-QGDPQPTVRW 274
Query: 691 RKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPP 750
+KD + G + K+ +L+I G Y CIA N + L VR PP
Sbjct: 275 KKDDADLPRG---RYDIKDDY-TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP 330
Query: 751 RFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGN---PQQYHPVPLTGRIQIL 807
+FVV+P +Q G+ C G P P V W+ +GS N P Q P R +
Sbjct: 331 QFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQ-KEGSQNLLFPNQ--PQQPNSRCSVS 387
Query: 808 PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMF-----LTVKIPAMITSHP-NTTIAI 861
P L I ++ D GYY+CQA G+ ++K+ LT + P +I P N T+A+
Sbjct: 388 PTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAV 447
Query: 862 KGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGD 921
G A L C A G+ +I W K + P R R I + TL++K D
Sbjct: 448 DGTAL-LKCKATGDPLPVISWLK-EGFTFPGRDPRATIQEQ-------GTLQIKNLRISD 498
Query: 922 SVFFSCHAINSYGEDRGLIQLTVQE--------------PPDPPELEIREVKARSMNLRW 967
+ ++C A +S GE L V E P P + ++ +V S+ L W
Sbjct: 499 TGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSW 558
Query: 968 TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNK 1027
G + + IE ++S S ++ ++ T+ + L P ++Y + + N
Sbjct: 559 QPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTL--YTVRGLRPNTIYLFMVRAINP 616
Query: 1028 IGRSEPS-KELTISTEEAAPDGPPMD------------------VTLQPVTSQSIQVTWK 1068
G S+PS + T++ +P +D V L P T +QVTW
Sbjct: 617 QGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTT---VQVTWT 673
Query: 1069 APKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSE-VYTLDNLKKFAQYGVVVQ 1127
+ Q I+GY++ YR+ S G S + A +E L NLKK Y + V+
Sbjct: 674 VDR---QPQFIQGYRVMYRQTS-GLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVR 729
Query: 1128 AFNRAGTGPSSSEINATTLEDVPSQPPENVRALSI---TSDVAVISWSEPPRSTLNGVLK 1184
+ G S T E+ PS PP++V L++ S +SW PP NG+++
Sbjct: 730 PYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQ 789
Query: 1185 GYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRS 1239
Y++ W L + + + + V + G+ Y V+V A T AG GV+S
Sbjct: 790 EYKI--WCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKS 842
Score = 149 bits (375), Expect = 4e-35
Identities = 195/839 (23%), Positives = 324/839 (38%), Gaps = 107/839 (12%)
Query: 565 PPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLL------PDNHRQVVFENGT 618
P + ++ G T +NC+ G P +I+WYKD + P +HR ++ +G+
Sbjct: 47 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLL-PSGS 105
Query: 619 LKLTDVQKGM----DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI----G 670
L + G DEG Y+C + + L + S + +++V L F P + G
Sbjct: 106 LFFLRIVHGRRSKPDEGSYVC--VARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 163
Query: 671 QLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS-----LQISSVSLKHNG 725
+ + C G I W+KD V I+ KE S L IS+ G
Sbjct: 164 EPAILECQPPRGHPEPTIYWKKDK--------VRIDDKEERISIRGGKLMISNTRKSDAG 215
Query: 726 NYTCIASNAAATVSRE-RQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWK 784
YTC+ +N + +L V P F+ +P NQ + +A C V G P P V WK
Sbjct: 216 MYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 275
Query: 785 HAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLT 844
+P GR I + +L I+ + D G Y+C A N VG + S LT
Sbjct: 276 KDDAD--------LP-RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK-MEASATLT 325
Query: 845 VKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEK--GDTVIDPDRVMR--YAIA 900
V+ P P I +G C +G + W+K ++ P++ + +
Sbjct: 326 VRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCS 385
Query: 901 TKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEP-PDPPELEIREVK 959
GD ++ ++ R D+ ++ C A+ G QL V + D P I +
Sbjct: 386 VSPTGDLTITNIQ-----RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGP 440
Query: 960 ARSMNLRWTQRFDGNSIITGFDIEYKNKSDSW---DFKQSTRNISPTINQANIVDLHPAS 1016
A T DG +++ SW F R+ TI + + +
Sbjct: 441 ANQ-----TLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLR 495
Query: 1017 VYSIRMYSF---NKIGRSEPSKELTISTEEAAPD---------GPPMDVTLQPVTSQSIQ 1064
+ Y+ + G + S L ++ A GPP + VT S+
Sbjct: 496 ISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVT 555
Query: 1065 VTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGV 1124
++W+ Y I S ++ Q +K T +YT+ L+ Y
Sbjct: 556 LSWQPGTPGTLPA--SAYIIEAFSQSVSNSWQTVANHVKTT----LYTVRGLRPNTIYLF 609
Query: 1125 VVQAFNRAGTGPSSSEINATTLEDV--PSQPPENVRALSITSDVAV-------------- 1168
+V+A N G S + +D+ P+Q ++ + DV V
Sbjct: 610 MVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQ 669
Query: 1169 ISWSEPPRSTLNGVLKGYRVIFWS---LYVDGEWGEMQNITTTRERVELRGMEKFTNYSV 1225
++W+ + ++GYRV++ L W + T L ++K Y +
Sbjct: 670 VTWTVDRQPQF---IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEI 726
Query: 1226 QVLAYTQAGDGVRSSVLYIQTKEDVPG-PPAGIKAVPS---SASSVVVSW--LPPTKPNG 1279
+V Y G+ S ++T E+ P PP + + +++S+ VSW PP NG
Sbjct: 727 KVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNG 786
Query: 1280 VIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE 1338
+I++Y I+C + + + + I L G QY + VAA TSAG G SE
Sbjct: 787 IIQEYKIWCLGNETRFHINKTVDAAIRSVI--IGGLFPGIQYRVEVAASTSAGVGVKSE 843
Score = 140 bits (353), Expect = 1e-32
Identities = 140/507 (27%), Positives = 211/507 (41%), Gaps = 63/507 (12%)
Query: 270 QSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP---- 325
Q G+RL D P I++ V G L C A G P P I W KDG
Sbjct: 34 QGQGSRLRQEDFP---PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETD 90
Query: 326 ----------LPADSRWTKRITGLTISDLRTE-DSGTYICEVTNTFGSAEATGILMVIDP 374
LP+ S + RI + R++ D G+Y+C N G A + + +
Sbjct: 91 KDDPRSHRMLLPSGSLFFLRI----VHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVAL 146
Query: 375 LH--VTLTPKKLKTGIGSTVILSC-ALTGSPEFTIRWYRN-TELVLPDEAISIRGLSNET 430
L P + G IL C G PE TI W ++ + +E ISIRG
Sbjct: 147 LRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG---GK 203
Query: 431 LLITSAQKSHSGAYQCFATRK-AQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMC 489
L+I++ +KS +G Y C T + D A + + + P + +VV E C
Sbjct: 204 LMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFE-RPTFLRRPINQVVLEEEAVEFRC 262
Query: 490 AAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARN 549
+G P PTV W DD + R + YT+ T+S D G Y C A N
Sbjct: 263 QVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMS---------TDEGTYMCIAEN 313
Query: 550 LVGSAEYQARINVRGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA---LLL 605
VG E A + VR PP + R+ GR C G P ++ W K+ LL
Sbjct: 314 RVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLF 373
Query: 606 PD-----NHRQVVFENGTLKLTDVQKGMDEGEYLC-------SVLIQPQLSISQSVHVAV 653
P+ N R V G L +T++Q+ D G Y+C S+L + QL ++ +
Sbjct: 374 PNQPQQPNSRCSVSPTGDLTITNIQRS-DAGYYICQALTVAGSILAKAQLEVTDV--LTD 430
Query: 654 KVPPLI-QPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMS 712
+ PP+I Q ++ + C + +P+ I+W K+G G +E
Sbjct: 431 RPPPIILQGPANQTLAVDGTALLKCKATGDPLPV-ISWLKEG-FTFPGRDPRATIQE-QG 487
Query: 713 SLQISSVSLKHNGNYTCIASNAAATVS 739
+LQI ++ + G YTC+A++++ S
Sbjct: 488 TLQIKNLRISDTGTYTCVATSSSGETS 514
Score = 124 bits (311), Expect = 1e-27
Identities = 130/491 (26%), Positives = 194/491 (39%), Gaps = 48/491 (9%)
Query: 95 VTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNS 154
V S + C A G P+ + WY G+ + H L P F
Sbjct: 56 VIVSKGEPTTLNCKAEGRPTPTIEWY-KDGERVETDKDDPRSHR----MLLPSGSLFFLR 110
Query: 155 FIH-------DNDYFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRSMRGNVAVFKC 206
+H + Y C A N G+ S N ++ A+ R+ + D G A+ +C
Sbjct: 111 IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 170
Query: 207 LIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSG 266
P E + W+KD V I + G L IS+ +K DA Y C+ + G
Sbjct: 171 QPPRGHPE--PTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDA-GMYTCVGTNMV-G 226
Query: 267 ETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPL 326
E R S+ A L+V + PT L +Q V VE C G P P +RW KD L
Sbjct: 227 E-RDSDPAELTVFER----PTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL 281
Query: 327 PADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKT 386
P K L I + D GTY+C N G EA+ L V P + P+
Sbjct: 282 PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIV 341
Query: 387 GIGSTVILSCALTGSPEFTIRWYR--NTELVLPDE--------AISIRGLSNETLLITSA 436
G TV C G+P+ + W + + L+ P++ ++S G L IT+
Sbjct: 342 AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG----DLTITNI 397
Query: 437 QKSHSGAYQCFATRKAQTAQDFAIIALED-----GTPRIVSSFSEKVVNPGEQFSLMCAA 491
Q+S +G Y C A A + A + + D P I+ + + + L C A
Sbjct: 398 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKA 457
Query: 492 KGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLV 551
G P P ++W E G R + T+ + T+ N+ +I D G Y C A +
Sbjct: 458 TGDPLPVISWL--KEGFTFPG--RDPRATIQEQGTLQIKNL---RISDTGTYTCVATSSS 510
Query: 552 GSAEYQARINV 562
G + A ++V
Sbjct: 511 GETSWSAVLDV 521
Score = 90.9 bits (224), Expect = 1e-17
Identities = 85/329 (25%), Positives = 127/329 (38%), Gaps = 28/329 (8%)
Query: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 220
Y C N G+ S + R + R +Q + F+C + Q V
Sbjct: 217 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQP---TVR 273
Query: 221 WEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD 280
W+KD + P R+ I L I D TY CI +++ + A L+V
Sbjct: 274 WKKDDADL-PRGRYDIKDDYTLRIKKTMSTDE-GTYMCIAENRVG---KMEASATLTVRA 328
Query: 281 PAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDG--------RPLPADSRW 332
P + + D Q V G TV PC G P PA+ W K+G +P +SR
Sbjct: 329 PPQFVVRPRD----QIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRC 384
Query: 333 TKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVID------PLHVTLTPKKLK 385
+ TG LTI++++ D+G YIC+ GS A L V D P + P
Sbjct: 385 SVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQT 444
Query: 386 TGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 445
+ T +L C TG P I W + P TL I + + S +G Y
Sbjct: 445 LAVDGTALLKCKATGDPLPVISWLKEG-FTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 503
Query: 446 CFATRKAQTAQDFAIIALEDGTPRIVSSF 474
C AT + A++ + + I ++
Sbjct: 504 CVATSSSGETSWSAVLDVTESGATISKNY 532
Score = 85.1 bits (209), Expect = 7e-16
Identities = 86/301 (28%), Positives = 127/301 (42%), Gaps = 34/301 (11%)
Query: 87 FVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRH-VHANGTLQLY 145
F+ + QV V C G P +RW D D+P R+ + + TL++
Sbjct: 243 FLRRPINQVVLEEEA-VEFRCQVQGDPQPTVRWK----KDDADLPRGRYDIKDDYTLRIK 297
Query: 146 PFSPSAFNSFIHDNDYFCTAENAAGKIR-SPNIRVKAVFREPYTVRVEDQRSMRGNVAVF 204
+ + Y C AEN GK+ S + V+A + VR DQ +G F
Sbjct: 298 KTMST------DEGTYMCIAENRVGKMEASATLTVRAP--PQFVVRPRDQIVAQGRTVTF 349
Query: 205 KCLIPSSVQEYVSVVSWEKDTVSII--------PEHRFFITYHGGLYISDVQKEDALSTY 256
C + Q V W+K+ + P R ++ G L I+++Q+ DA Y
Sbjct: 350 PCETKGNPQP---AVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDA--GY 404
Query: 257 RCITKHKYSGETRQSNGARLSVTDPAESIPT--ILDGFHSQEVWAGHTVELPCTASGYPI 314
+G A+L VTD P IL G +Q + T L C A+G P+
Sbjct: 405 YICQALTVAGSILAK--AQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPL 462
Query: 315 PAIRWLKDGRPLPA-DSRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVI 372
P I WLK+G P D R T + G L I +LR D+GTY C T++ G + +L V
Sbjct: 463 PVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVT 522
Query: 373 D 373
+
Sbjct: 523 E 523
Score = 62.8 bits (151), Expect = 3e-09
Identities = 65/279 (23%), Positives = 104/279 (37%), Gaps = 43/279 (15%)
Query: 1282 RKYTIFCSSPGSGQPAPSEYETSPEQLFY-------------------RIAHLNRGQQYL 1322
R T C + G+ QPA + + L + I ++ R
Sbjct: 345 RTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGY 404
Query: 1323 LWVAAVTSAGR--GNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPA 1380
A+T AG + +VT + P I+ T L C + GDP P
Sbjct: 405 YICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPV 464
Query: 1381 VKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV 1440
+ W K E P D I GTL ++ ++ D+G YTC AT++ G + L V
Sbjct: 465 ISWLK--EGFTFP-GRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 521
Query: 1441 QV----------------PPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQ-YSVD 1483
PP +P++T + +S+TL+W PG G ++++ +S
Sbjct: 522 TESGATISKNYDLSDLPGPPSKPQVT--DVTKNSVTLSWQPGTPGTLPASAYIIEAFSQS 579
Query: 1484 NSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVG 1522
S W+ V + + L+ T Y + A N G
Sbjct: 580 VSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQG 618
Score = 43.1 bits (100), Expect = 0.003
Identities = 27/78 (34%), Positives = 35/78 (44%), Gaps = 5/78 (6%)
Query: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTAT 1426
V C GDP P V+W KD D+ +P G I + TL ++ + D G Y C A
Sbjct: 258 VEFRCQVQGDPQPTVRWKKD--DADLP---RGRYDIKDDYTLRIKKTMSTDEGTYMCIAE 312
Query: 1427 NTGGFDTIIVNLLVQVPP 1444
N G L V+ PP
Sbjct: 313 NRVGKMEASATLTVRAPP 330
Score = 38.5 bits (88), Expect = 0.070
Identities = 33/115 (28%), Positives = 47/115 (40%), Gaps = 12/115 (10%)
Query: 1322 LLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAV 1381
LL + V +GN + + P +I+ V + L C + G P P +
Sbjct: 19 LLMMTVVFWGHQGNGQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTI 78
Query: 1382 KWTKDSE----DSAIPVSMDGHRLIHTNGTL-LLRAVKAE----DSGYYTCTATN 1427
+W KD E D P S HR++ +G+L LR V D G Y C A N
Sbjct: 79 EWYKDGERVETDKDDPRS---HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARN 130
Score = 35.8 bits (81), Expect = 0.46
Identities = 17/56 (30%), Positives = 25/56 (44%), Gaps = 4/56 (7%)
Query: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
G P P + W KD + + R+ G L++ + D+G YTC TN G
Sbjct: 175 GHPEPTIYWKKDK----VRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVG 226
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 232 bits (591), Expect = 3e-60
Identities = 225/835 (26%), Positives = 358/835 (42%), Gaps = 94/835 (11%)
Query: 464 EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRD-GSHRTNQYTMS 522
ED PRIV S+ +V+ GE +L C A+G P PT+ W D E + D R+++ +
Sbjct: 27 EDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 86
Query: 523 DGTTISHMNVTGPQIR-DGGVYRCTARNLVGSAEYQ--------ARINVRGPPSIRAMRN 573
G+ V G + + D G Y C ARN +G A + R + R P+ +
Sbjct: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT-----D 141
Query: 574 ITAVAGRDTLINCR-VIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632
+ AG ++ C+ G+P +I W KD + + D ++ G L +++ +K D G
Sbjct: 142 VVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKS-DAGM 200
Query: 633 YLC--SVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITW 690
Y C + ++ + S + V + L +P + + C V GD + W
Sbjct: 201 YTCVGTNMVGERDSDPAELTVFERPTFLRRPIN-QVVLEEEAVEFRCQV-QGDPQPTVRW 258
Query: 691 RKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPP 750
+KD + G + K+ +L+I G Y CIA N + L VR PP
Sbjct: 259 KKDDADLPRG---RYDIKDDY-TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP 314
Query: 751 RFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGN---PQQYHPVPLTGRIQIL 807
+FVV+P +Q G+ C G P P V W+ +GS N P Q P R +
Sbjct: 315 QFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQ-KEGSQNLLFPNQ--PQQPNSRCSVS 371
Query: 808 PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMF-----LTVKIPAMITSHP-NTTIAI 861
P L I ++ D GYY+CQA G+ ++K+ LT + P +I P N T+A+
Sbjct: 372 PTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAV 431
Query: 862 KGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGD 921
G A L C A G+ +I W K + P R R I + TL++K D
Sbjct: 432 DGTAL-LKCKATGDPLPVISWLK-EGFTFPGRDPRATIQEQ-------GTLQIKNLRISD 482
Query: 922 SVFFSCHAINSYGEDRGLIQLTVQE--------------PPDPPELEIREVKARSMNLRW 967
+ ++C A +S GE L V E P P + ++ +V S+ L W
Sbjct: 483 TGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSW 542
Query: 968 TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNK 1027
G + + IE ++S S ++ ++ T+ + L P ++Y + + N
Sbjct: 543 QPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTL--YTVRGLRPNTIYLFMVRAINP 600
Query: 1028 IGRSEPS-KELTISTEEAAPDGPPMD------------------VTLQPVTSQSIQVTWK 1068
G S+PS + T++ +P +D V L P T +QVTW
Sbjct: 601 QGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTT---VQVTWT 657
Query: 1069 APKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSE-VYTLDNLKKFAQYGVVVQ 1127
+ Q I+GY++ YR+ S G S + A +E L NLKK Y + V+
Sbjct: 658 VDR---QPQFIQGYRVMYRQTS-GLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVR 713
Query: 1128 AFNRAGTGPSSSEINATTLEDVPSQPPENVRALSI---TSDVAVISWSEPPRSTLNGVLK 1184
+ G S T E+ PS PP++V L++ S +SW PP NG+++
Sbjct: 714 PYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQ 773
Query: 1185 GYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRS 1239
Y++ W L + + + + V + G+ Y V+V A T AG GV+S
Sbjct: 774 EYKI--WCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKS 826
Score = 149 bits (375), Expect = 4e-35
Identities = 195/839 (23%), Positives = 324/839 (38%), Gaps = 107/839 (12%)
Query: 565 PPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLL------PDNHRQVVFENGT 618
P + ++ G T +NC+ G P +I+WYKD + P +HR ++ +G+
Sbjct: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLL-PSGS 89
Query: 619 LKLTDVQKGM----DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI----G 670
L + G DEG Y+C + + L + S + +++V L F P + G
Sbjct: 90 LFFLRIVHGRRSKPDEGSYVC--VARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 147
Query: 671 QLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS-----LQISSVSLKHNG 725
+ + C G I W+KD V I+ KE S L IS+ G
Sbjct: 148 EPAILECQPPRGHPEPTIYWKKDK--------VRIDDKEERISIRGGKLMISNTRKSDAG 199
Query: 726 NYTCIASNAAATVSRE-RQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWK 784
YTC+ +N + +L V P F+ +P NQ + +A C V G P P V WK
Sbjct: 200 MYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 259
Query: 785 HAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLT 844
+P GR I + +L I+ + D G Y+C A N VG + S LT
Sbjct: 260 KDDAD--------LP-RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK-MEASATLT 309
Query: 845 VKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEK--GDTVIDPDRVMR--YAIA 900
V+ P P I +G C +G + W+K ++ P++ + +
Sbjct: 310 VRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCS 369
Query: 901 TKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEP-PDPPELEIREVK 959
GD ++ ++ R D+ ++ C A+ G QL V + D P I +
Sbjct: 370 VSPTGDLTITNIQ-----RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGP 424
Query: 960 ARSMNLRWTQRFDGNSIITGFDIEYKNKSDSW---DFKQSTRNISPTINQANIVDLHPAS 1016
A T DG +++ SW F R+ TI + + +
Sbjct: 425 ANQ-----TLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLR 479
Query: 1017 VYSIRMYSF---NKIGRSEPSKELTISTEEAAPD---------GPPMDVTLQPVTSQSIQ 1064
+ Y+ + G + S L ++ A GPP + VT S+
Sbjct: 480 ISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVT 539
Query: 1065 VTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGV 1124
++W+ Y I S ++ Q +K T +YT+ L+ Y
Sbjct: 540 LSWQPGTPGTLPA--SAYIIEAFSQSVSNSWQTVANHVKTT----LYTVRGLRPNTIYLF 593
Query: 1125 VVQAFNRAGTGPSSSEINATTLEDV--PSQPPENVRALSITSDVAV-------------- 1168
+V+A N G S + +D+ P+Q ++ + DV V
Sbjct: 594 MVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQ 653
Query: 1169 ISWSEPPRSTLNGVLKGYRVIFWS---LYVDGEWGEMQNITTTRERVELRGMEKFTNYSV 1225
++W+ + ++GYRV++ L W + T L ++K Y +
Sbjct: 654 VTWTVDRQPQF---IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEI 710
Query: 1226 QVLAYTQAGDGVRSSVLYIQTKEDVPG-PPAGIKAVPS---SASSVVVSW--LPPTKPNG 1279
+V Y G+ S ++T E+ P PP + + +++S+ VSW PP NG
Sbjct: 711 KVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNG 770
Query: 1280 VIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE 1338
+I++Y I+C + + + + I L G QY + VAA TSAG G SE
Sbjct: 771 IIQEYKIWCLGNETRFHINKTVDAAIRSVI--IGGLFPGIQYRVEVAASTSAGVGVKSE 827
Score = 139 bits (349), Expect = 4e-32
Identities = 135/491 (27%), Positives = 205/491 (41%), Gaps = 60/491 (12%)
Query: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP--------------LPADSR 331
P I++ V G L C A G P P I W KDG LP+ S
Sbjct: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
Query: 332 WTKRITGLTISDLRTE-DSGTYICEVTNTFGSAEATGILMVIDPLH--VTLTPKKLKTGI 388
+ RI + R++ D G+Y+C N G A + + + L P +
Sbjct: 91 FFLRI----VHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA 146
Query: 389 GSTVILSC-ALTGSPEFTIRWYRN-TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQC 446
G IL C G PE TI W ++ + +E ISIRG L+I++ +KS +G Y C
Sbjct: 147 GEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG---GKLMISNTRKSDAGMYTC 203
Query: 447 FATRK-AQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDD 505
T + D A + + + P + +VV E C +G P PTV W DD
Sbjct: 204 VGTNMVGERDSDPAELTVFE-RPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDD 262
Query: 506 EPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGP 565
+ R + YT+ T+S D G Y C A N VG E A + VR P
Sbjct: 263 ADLPRGRYDIKDDYTLRIKKTMS---------TDEGTYMCIAENRVGKMEASATLTVRAP 313
Query: 566 PS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA---LLLPD-----NHRQVVFEN 616
P + R+ GR C G P ++ W K+ LL P+ N R V
Sbjct: 314 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
Query: 617 GTLKLTDVQKGMDEGEYLC-------SVLIQPQLSISQSVHVAVKVPPLI-QPFEFPPAS 668
G L +T++Q+ D G Y+C S+L + QL ++ + + PP+I Q +
Sbjct: 374 GDLTITNIQRS-DAGYYICQALTVAGSILAKAQLEVTDV--LTDRPPPIILQGPANQTLA 430
Query: 669 IGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYT 728
+ + C + +P+ I+W K+G G +E +LQI ++ + G YT
Sbjct: 431 VDGTALLKCKATGDPLPV-ISWLKEG-FTFPGRDPRATIQE-QGTLQIKNLRISDTGTYT 487
Query: 729 CIASNAAATVS 739
C+A++++ S
Sbjct: 488 CVATSSSGETS 498
Score = 127 bits (319), Expect = 1e-28
Identities = 191/832 (22%), Positives = 317/832 (38%), Gaps = 102/832 (12%)
Query: 374 PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDE--------AISIRG 425
P + P + G L+C G P TI WY++ E V D+ +
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
Query: 426 LSNETLLITSAQKSHSGAYQCFATRKAQTA----QDFAIIALEDGTPRIVSSFSEKVVNP 481
L ++ K G+Y C A A + L D + ++ VV
Sbjct: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD---FRQNPTDVVVAA 146
Query: 482 GEQFSLMC-AAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDG 540
GE L C +G P PT+ W D I + + ++ G + ++ + D
Sbjct: 147 GEPAILECQPPRGHPEPTIYWKKDKVRI----DDKEERISIRGG----KLMISNTRKSDA 198
Query: 541 GVYRCTARNLVGSAEYQ-ARINV-RGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKW 598
G+Y C N+VG + A + V P +R N + C+V G P +++W
Sbjct: 199 GMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRW 258
Query: 599 YKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPP- 657
KD LP R + ++ TL++ DEG Y+C + + S + V+ PP
Sbjct: 259 KKDDADLP-RGRYDIKDDYTLRIKKTM-STDEGTYMC-IAENRVGKMEASATLTVRAPPQ 315
Query: 658 -LIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDG--QVIISGSGVTIESKEFMS-- 712
+++P + A G+ + PC P + W+K+G ++ S+ +S
Sbjct: 316 FVVRPRDQIVAQ-GRTVTFPCETKGNPQP-AVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
Query: 713 -SLQISSVSLKHNGNYTCIASNAAATVSRERQLIV------RVPPRFVVQPNNQDGIYGK 765
L I+++ G Y C A A ++ + QL V R PP + P NQ
Sbjct: 374 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG 433
Query: 766 AGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYY 825
+L C G P P + W +G P + R I +L I+++ D G Y
Sbjct: 434 TALLKCKATGDPLPVISWL-KEGFTFPGR------DPRATIQEQGTLQIKNLRISDTGTY 486
Query: 826 LCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKG 885
C A++ G + S S L V S + G + T + + + W+ G
Sbjct: 487 TCVATSSSG-ETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPG 545
Query: 886 DTVIDPDR---VMRYAIATKDN----GDEVVSTLKLKPADRGDSVF-FSCHAINSYG--E 935
P + ++ + ++ + V +TL R ++++ F AIN G +
Sbjct: 546 TPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSD 605
Query: 936 DRGLIQLTVQEPPDPP---------ELEIREVKAR----------SMNLRWTQRFDGNSI 976
+ + PP + E+ +V R ++ + WT
Sbjct: 606 PSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQ-PQF 664
Query: 977 ITGFDIEYKNKS-----DSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRS 1031
I G+ + Y+ S SW Q+ PT A +V+L Y I++ + +
Sbjct: 665 IQGYRVMYRQTSGLQATSSW---QNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQG 721
Query: 1032 EPSKELTISTEEAAPDGPPMDVTLQPV---TSQSIQVTWKAPKKELQNGVIRGYQIGYRE 1088
S+ T+ T E AP PP VT+ V S SI V+W P + QNG+I+ Y+I
Sbjct: 722 MDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI---- 777
Query: 1089 NSPGSNGQYSIVEMKATGDSEVYT--LDNLKKFAQYGVVVQAFNRAGTGPSS 1138
G + + T D+ + + + L QY V V A AG G S
Sbjct: 778 ---WCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKS 826
Score = 124 bits (311), Expect = 1e-27
Identities = 130/491 (26%), Positives = 194/491 (39%), Gaps = 48/491 (9%)
Query: 95 VTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNS 154
V S + C A G P+ + WY G+ + H L P F
Sbjct: 40 VIVSKGEPTTLNCKAEGRPTPTIEWY-KDGERVETDKDDPRSHR----MLLPSGSLFFLR 94
Query: 155 FIH-------DNDYFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRSMRGNVAVFKC 206
+H + Y C A N G+ S N ++ A+ R+ + D G A+ +C
Sbjct: 95 IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 154
Query: 207 LIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSG 266
P E + W+KD V I + G L IS+ +K DA Y C+ + G
Sbjct: 155 QPPRGHPE--PTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDA-GMYTCVGTNMV-G 210
Query: 267 ETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPL 326
E R S+ A L+V + PT L +Q V VE C G P P +RW KD L
Sbjct: 211 E-RDSDPAELTVFER----PTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL 265
Query: 327 PADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKT 386
P K L I + D GTY+C N G EA+ L V P + P+
Sbjct: 266 PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIV 325
Query: 387 GIGSTVILSCALTGSPEFTIRWYR--NTELVLPDE--------AISIRGLSNETLLITSA 436
G TV C G+P+ + W + + L+ P++ ++S G L IT+
Sbjct: 326 AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG----DLTITNI 381
Query: 437 QKSHSGAYQCFATRKAQTAQDFAIIALED-----GTPRIVSSFSEKVVNPGEQFSLMCAA 491
Q+S +G Y C A A + A + + D P I+ + + + L C A
Sbjct: 382 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKA 441
Query: 492 KGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLV 551
G P P ++W E G R + T+ + T+ N+ +I D G Y C A +
Sbjct: 442 TGDPLPVISWL--KEGFTFPG--RDPRATIQEQGTLQIKNL---RISDTGTYTCVATSSS 494
Query: 552 GSAEYQARINV 562
G + A ++V
Sbjct: 495 GETSWSAVLDV 505
Score = 85.1 bits (209), Expect = 7e-16
Identities = 86/301 (28%), Positives = 127/301 (42%), Gaps = 34/301 (11%)
Query: 87 FVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRH-VHANGTLQLY 145
F+ + QV V C G P +RW D D+P R+ + + TL++
Sbjct: 227 FLRRPINQVVLEEEA-VEFRCQVQGDPQPTVRWK----KDDADLPRGRYDIKDDYTLRIK 281
Query: 146 PFSPSAFNSFIHDNDYFCTAENAAGKIR-SPNIRVKAVFREPYTVRVEDQRSMRGNVAVF 204
+ + Y C AEN GK+ S + V+A + VR DQ +G F
Sbjct: 282 KTMST------DEGTYMCIAENRVGKMEASATLTVRAP--PQFVVRPRDQIVAQGRTVTF 333
Query: 205 KCLIPSSVQEYVSVVSWEKDTVSII--------PEHRFFITYHGGLYISDVQKEDALSTY 256
C + Q V W+K+ + P R ++ G L I+++Q+ DA Y
Sbjct: 334 PCETKGNPQP---AVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDA--GY 388
Query: 257 RCITKHKYSGETRQSNGARLSVTDPAESIPT--ILDGFHSQEVWAGHTVELPCTASGYPI 314
+G A+L VTD P IL G +Q + T L C A+G P+
Sbjct: 389 YICQALTVAGSILAK--AQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPL 446
Query: 315 PAIRWLKDGRPLPA-DSRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVI 372
P I WLK+G P D R T + G L I +LR D+GTY C T++ G + +L V
Sbjct: 447 PVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVT 506
Query: 373 D 373
+
Sbjct: 507 E 507
Score = 62.8 bits (151), Expect = 3e-09
Identities = 65/279 (23%), Positives = 104/279 (37%), Gaps = 43/279 (15%)
Query: 1282 RKYTIFCSSPGSGQPAPSEYETSPEQLFY-------------------RIAHLNRGQQYL 1322
R T C + G+ QPA + + L + I ++ R
Sbjct: 329 RTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGY 388
Query: 1323 LWVAAVTSAGR--GNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPA 1380
A+T AG + +VT + P I+ T L C + GDP P
Sbjct: 389 YICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPV 448
Query: 1381 VKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV 1440
+ W K E P D I GTL ++ ++ D+G YTC AT++ G + L V
Sbjct: 449 ISWLK--EGFTFP-GRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
Query: 1441 QV----------------PPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQ-YSVD 1483
PP +P++T + +S+TL+W PG G ++++ +S
Sbjct: 506 TESGATISKNYDLSDLPGPPSKPQVT--DVTKNSVTLSWQPGTPGTLPASAYIIEAFSQS 563
Query: 1484 NSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVG 1522
S W+ V + + L+ T Y + A N G
Sbjct: 564 VSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQG 602
Score = 43.1 bits (100), Expect = 0.003
Identities = 27/78 (34%), Positives = 35/78 (44%), Gaps = 5/78 (6%)
Query: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTAT 1426
V C GDP P V+W KD D+ +P G I + TL ++ + D G Y C A
Sbjct: 242 VEFRCQVQGDPQPTVRWKKD--DADLP---RGRYDIKDDYTLRIKKTMSTDEGTYMCIAE 296
Query: 1427 NTGGFDTIIVNLLVQVPP 1444
N G L V+ PP
Sbjct: 297 NRVGKMEASATLTVRAPP 314
Score = 38.1 bits (87), Expect = 0.092
Identities = 28/88 (31%), Positives = 38/88 (43%), Gaps = 12/88 (13%)
Query: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE----DSAIPVSMDGHRLIHT 1404
P +I+ V + L C + G P P ++W KD E D P S HR++
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS---HRMLLP 86
Query: 1405 NGTL-LLRAVKAE----DSGYYTCTATN 1427
+G+L LR V D G Y C A N
Sbjct: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARN 114
Score = 35.8 bits (81), Expect = 0.46
Identities = 17/56 (30%), Positives = 25/56 (44%), Gaps = 4/56 (7%)
Query: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
G P P + W KD + + R+ G L++ + D+G YTC TN G
Sbjct: 159 GHPEPTIYWKKDK----VRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVG 210
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 229 bits (585), Expect = 2e-59
Identities = 259/1008 (25%), Positives = 420/1008 (41%), Gaps = 101/1008 (10%)
Query: 680 SSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS-LQISSVSL-KHNGNYTCIASNAAAT 737
++GD +I W K G+ + + IE + S L+I + + Y C+ASN
Sbjct: 47 ATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGE 106
Query: 738 VSRERQLIV----RVP---PRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSG 790
+S +L V ++P P + P + + + C+ G P P++ W
Sbjct: 107 ISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWF------ 160
Query: 791 NPQQYHPVPLT---GRIQILPNSS---------LLIRHVLEEDIGYYLCQASNGVGTDIS 838
+ + PV + GRI+ L + S L I E D G Y C A+N GT S
Sbjct: 161 --KDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYS 218
Query: 839 KSMFLTVK-------IPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP 891
L V+ +P + P + G + + C A G ++W G + P
Sbjct: 219 APANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTP 278
Query: 892 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP 951
+ D + L+ D S ++C A+++ G + Q+TV+ P PP
Sbjct: 279 E------------DDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPP 326
Query: 952 ELEI-REVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIV 1010
+ E A S+ L W GN + I +S + + ++ T + ++
Sbjct: 327 GTPVVTESTATSITLTWDS---GNPEPVSYYIIQHKPKNSEELYKEIDGVATT--RYSVA 381
Query: 1011 DLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAP 1070
L P S Y R+ + N IGR PS+ + T E AP P DV + ++S +I V WK P
Sbjct: 382 GLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEP 441
Query: 1071 KKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFN 1130
E NG I+GY++ Y + + DS++ T+ NL Y V V AF
Sbjct: 442 --EEPNGQIQGYRVYYTMDPTQHVNNWM---KHNVADSQITTIGNLVPQKTYSVKVLAFT 496
Query: 1131 RAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIF 1190
G GP SS+I T VP Q P N +A + ++SW+ PPRS + Y ++
Sbjct: 497 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWT-PPRS---DTIANYELV- 550
Query: 1191 WSLYVDGEWGEMQNIT-TTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKED 1249
Y DGE GE Q IT L+G++ + Y ++ A + G G ++ + +T +
Sbjct: 551 ---YKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607
Query: 1250 VP-GPPAGIKAVPSSASSVVVSWLPP--TKPNGVIRKYTIFCSSPGSGQPAPSEYETSP- 1305
P PP I S++S++VSW PP K NG+I +Y+I ++ P E P
Sbjct: 608 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPS 667
Query: 1306 EQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTI---EPAGKAPAKIISFGGTVTTP 1362
+ Y + L + +Y + V A T G G S V I E P + + +T
Sbjct: 668 DTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS 727
Query: 1363 WMKDVRLPCNSV------GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAE 1416
R P + G V+ ++ E P+ D ++ +++ ++ E
Sbjct: 728 VKVSWRSPVPNKQHGQIRGYQVHYVR-MENGEPKGQPMLKD--VMLADAQDMIISGLQPE 784
Query: 1417 DSGYYTCTATNTGGFDTIIVNLLVQVP---PDQPRLTVSKTSASSITLTWIPGDNGGSSI 1473
S T TA T G LV P +PRL ++ T ++ + W P + +
Sbjct: 785 TSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPL 844
Query: 1474 RGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAK 1533
+G+ L++ + E + S E F + G Y +L+A+N VG G E+++
Sbjct: 845 QGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEI 902
Query: 1534 THGREPSFSKDQHLFTH-INSTHARLNLQ----GWNNGGCPITAIVLEYRPKG--TWAWQ 1586
+ E Q+L + ST +L+ Q NG IT L YR +
Sbjct: 903 SIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNG--IITKYTLLYRDINIPLLPME 960
Query: 1587 GLRANSSGEVFLTELREATWYELRMRACNSAGCG--NETAQFATLDYD 1632
L + + LT L+ T Y++++RA S G G + + QF TL D
Sbjct: 961 QLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVD 1008
Score = 220 bits (560), Expect = 1e-56
Identities = 263/1082 (24%), Positives = 435/1082 (40%), Gaps = 150/1082 (13%)
Query: 547 ARNLVGSAEYQARINVRGPPSI-RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLL 605
AR L+ + R + PP R + T V+G C+ G P I W K +
Sbjct: 5 ARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKV 64
Query: 606 PDNHRQVV-FENGT---LKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQP 661
+ +V+ F++G+ L++ ++ DE Y C V IS S + V I P
Sbjct: 65 SNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYEC-VASNNVGEISVSTRLTVLREDQI-P 122
Query: 662 FEFPPASIGQLLYIP--------CVVSSGDMPIRITWRKDGQVIISGSG---------VT 704
FP +G L + +SG+ ITW KD + + + +
Sbjct: 123 RGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSES 182
Query: 705 IESKEFMSSLQISSVSLKHNGNYTCIASNAAAT--------VSRERQLIVRVPPRFVVQP 756
I +LQI G Y C+A+N+A T RE + + RVPPRF + P
Sbjct: 183 IGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPP 242
Query: 757 NNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRH 816
N + + G + + C G P P V W P+ P+ R+
Sbjct: 243 TNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIG---------------RN 287
Query: 817 VLE----EDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTA 872
VLE Y C A + +G I +TVK + P T + + A + T
Sbjct: 288 VLELNDVRQSANYTCVAMSTLGV-IEAIAQITVKA---LPKPPGTPVVTESTATSITLT- 342
Query: 873 RGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEV-------VSTLKLKPADRG--DSV 923
W+ G+ P+ V Y I K E V+T + A
Sbjct: 343 ---------WDSGN----PEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDY 389
Query: 924 FFSCHAINSYGE----DRGLIQLTVQEPPDPP-ELEIREVKARSMNLRWTQRFDGNSIIT 978
F A+N+ G + L Q + Q P P +++ R + + ++ ++W + + N I
Sbjct: 390 EFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQ 449
Query: 979 GFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELT 1038
G+ + Y N++ + I +L P YS+++ +F IG S ++
Sbjct: 450 GYRVYYTMDPTQHVNNWMKHNVADS-QITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQ 508
Query: 1039 ISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYS 1098
+ T+ P G P++ +P + SI ++W P+ + I Y++ Y++ G + +
Sbjct: 509 VITQTGVP-GQPLNFKAEPESETSILLSWTPPRSD----TIANYELVYKDGEHGEEQRIT 563
Query: 1099 IVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVR 1158
I G S Y L LK + Y + A + G G S++EI+A T++ PS PP+++
Sbjct: 564 I----EPGTS--YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDIS 617
Query: 1159 ALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWG---EMQNITTTRERVELR 1215
S +S ++SW PP NG++ Y + + + VDGE E+ I + + L
Sbjct: 618 CTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA--VDGEDDKPHEILGIPSDTTKYLLE 675
Query: 1216 GMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP-GPPAGIKAVPSSASSVVVSWLPP 1274
+EK+T Y + V A+T G G S + I+T EDVP GPP ++ +++SV VSW P
Sbjct: 676 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSP 735
Query: 1275 T--KPNGVIRKYTIFC----SSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAV 1328
K +G IR Y + + GQP + + Q I+ L Y L V A
Sbjct: 736 VPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMI-ISGLQPETSYSLTVTAY 794
Query: 1329 TSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE 1388
T+ G G S+ + G P K RL N ++W +
Sbjct: 795 TTKGDGARSKPKLVSTTGAVPGK---------------PRLVINHTQMNTALIQWHPPVD 839
Query: 1389 DSAIPVSMDGHRLIHTNGTL--LLRAVKAEDSGYYTCT-------------ATNTGGFDT 1433
+ G+RL + L +E ++T T A N GF
Sbjct: 840 TFG---PLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGE 896
Query: 1434 IIVNLLVQVPPDQP-----RLTVSKTSASSITLTWIP---GDNGGSSIRGFVLQYSVDNS 1485
+V + +P + P L T+++S+ L+W P + G + +L ++
Sbjct: 897 EMVKE-ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIP 955
Query: 1486 EEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQ 1545
+ I ++ + L LK T Y VK+ A S G G S ++ +T + F+K+
Sbjct: 956 LLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNF 1015
Query: 1546 HL 1547
H+
Sbjct: 1016 HV 1017
Score = 154 bits (388), Expect = 1e-36
Identities = 211/922 (22%), Positives = 366/922 (39%), Gaps = 95/922 (10%)
Query: 749 PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPL-TGRIQIL 807
PPRF P +Q G+ G C G P PK++W + Q++ + G +L
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVL 82
Query: 808 PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTV----KIP---AMITSHPNTTIA 860
L D Y C ASN VG +IS S LTV +IP I P +
Sbjct: 83 RIQPLR----TPRDEAIYECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQLKVV 137
Query: 861 IKGHAKELNCTARGERPIIIRWEKGDTVIDPDR---VMRYAIATKDNGDEVVSTLKLKPA 917
+ + C A G I W K +D ++ + G + L+++ +
Sbjct: 138 ERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQS 197
Query: 918 DRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVK-ARSMNLRWTQRFDGNSI 976
+ D + C A NS G P L +RE++ R + R++ + I
Sbjct: 198 EESDQGKYECVATNSAGTRYSA----------PANLYVRELREVRRVPPRFSIPPTNHEI 247
Query: 977 ITGFDIEYK-----NKSDSWDFKQSTRNISPTINQ---ANIVDLHPA-SVYSIRMYSFNK 1027
+ G + + + +++P + N+++L+ + + +
Sbjct: 248 MPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMST 307
Query: 1028 IGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYR 1087
+G E ++T+ +A P PP + T+ SI +TW + E + Y I ++
Sbjct: 308 LGVIEAIAQITV---KALPK-PPGTPVVTESTATSITLTWDSGNPE----PVSYYIIQHK 359
Query: 1088 ENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLE 1147
+ S Y ++ AT Y++ L ++ Y V A N G GP S + T E
Sbjct: 360 PKN--SEELYKEIDGVAT---TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 414
Query: 1148 DVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITT 1207
PS P +V+A ++S ++ W EP NG ++GYRV + M++
Sbjct: 415 QAPSSAPRDVQARMLSSTTILVQWKEPEEP--NGQIQGYRVYYTMDPTQHVNNWMKHNVA 472
Query: 1208 TRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSV 1267
+ + + YSV+VLA+T GDG SS + + T+ VPG P KA P S +S+
Sbjct: 473 DSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Query: 1268 VVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAA 1327
++SW PP + I Y + G+ + T YR+ L Y +AA
Sbjct: 533 LLSWTPPR--SDTIANYELVYK---DGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 587
Query: 1328 VTSAGRGNSSEKV---TIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWT 1384
+ G G S+ ++ T++ AP + IS T+P + + P P K
Sbjct: 588 RSPQGLGASTAEISARTMQSKPSAPPQDIS----CTSPSSTSILVS----WQPPPVEKQN 639
Query: 1385 KDSEDSAIP-VSMDG-----HRLI---HTNGTLLLRAVKAEDSGYYTCTATNTGGFDTII 1435
+ +I ++DG H ++ LL ++ T TA G
Sbjct: 640 GIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPES 699
Query: 1436 VNLLVQVPPDQP-----RLTVSKTSASSITLTW---IPGDNGGSSIRGFVLQY-SVDNSE 1486
+++L++ D P ++ V +++S+ ++W +P G IRG+ + Y ++N E
Sbjct: 700 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHG-QIRGYQVHYVRMENGE 758
Query: 1487 E-----WKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSF 1541
KDV ++ ++ + L+ T Y + + A + G G S+ T G P
Sbjct: 759 PKGQPMLKDVMLADAQ-DMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVP-- 815
Query: 1542 SKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVF-LTE 1600
K + + H A + + P+ L++ K L + + F T+
Sbjct: 816 GKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATD 875
Query: 1601 LREATWYELRMRACNSAGCGNE 1622
+ + Y R+ A N G G E
Sbjct: 876 IHKGASYVFRLSARNKVGFGEE 897
Score = 114 bits (286), Expect = 8e-25
Identities = 151/657 (22%), Positives = 252/657 (38%), Gaps = 69/657 (10%)
Query: 857 TTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKD--NGDEVVSTL-- 912
T + G E I++ W T D + Y + KD +G+E T+
Sbjct: 511 TQTGVPGQPLNFKAEPESETSILLSW----TPPRSDTIANYELVYKDGEHGEEQRITIEP 566
Query: 913 ----KLKPADRGDSVFFSCHAINSYGEDRGLIQL---TVQEPPDPPELEIR--EVKARSM 963
+L+ +F A + G ++ T+Q P P +I + S+
Sbjct: 567 GTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 626
Query: 964 NLRWTQR--FDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIR 1021
+ W N IIT + I+Y D I + + L + Y I
Sbjct: 627 LVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRIT 686
Query: 1022 MYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRG 1081
+ + +G S + I T E P GPP V ++ V S S++V+W++P Q+G IRG
Sbjct: 687 VTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRG 746
Query: 1082 YQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEI 1141
YQ+ Y G +++ D++ + L+ Y + V A+ G G S
Sbjct: 747 YQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPK 806
Query: 1142 NATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGE 1201
+T VP +P + + + A+I W PP T G L+GYR+ F +
Sbjct: 807 LVSTTGAVPGKPRLVINHTQM--NTALIQW-HPPVDTF-GPLQGYRLKFGR-------KD 855
Query: 1202 MQNITT-----TRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP-GPPA 1255
M+ +TT + + K +Y ++ A + G G V I E+VP G P
Sbjct: 856 MEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG-EEMVKEISIPEEVPTGFPQ 914
Query: 1256 GIKAVPSSASSVVVSWLPP--TKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIA 1313
+ + ++++SV +SW PP + NG+I KYT+ P E P +
Sbjct: 915 NLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINI-PLLPMEQLIVPADTTMTLT 973
Query: 1314 HLNRGQQYLLWVAAVTSAGRGNSSEKVTIE--PAGKAPAKIISFGGTVTTPWMKDVRLPC 1371
L Y + V A TS G G S V P + AK + T + +P
Sbjct: 974 GLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIP- 1032
Query: 1372 NSVGDPAPAVKWTKDSEDSAIPVSM---DGHRLIHTNGTL---LLRAVKAEDSGYYTCTA 1425
++ +SA+P + DG + +G L+ +K E S Y+
Sbjct: 1033 --------------ENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS--YSFVL 1076
Query: 1426 TNTG-GFDTIIVNLLVQVPPDQPRLT---VSKTSASSITLTWIPGDNGGSSIRGFVL 1478
TN G + + + PD R + KT+ + +P +I+G+ +
Sbjct: 1077 TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYI 1133
Score = 63.5 bits (153), Expect = 2e-09
Identities = 90/421 (21%), Positives = 145/421 (34%), Gaps = 61/421 (14%)
Query: 177 IRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFI 236
+R A +T DQ + G VA F C + + W K + + I
Sbjct: 16 LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIV---WNKKGKKVSNQRFEVI 72
Query: 237 TYHGG----LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGF 292
+ G L I ++ + Y C+ + + + L PTI G
Sbjct: 73 EFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGP 132
Query: 293 HSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP------------LPADSRWTKRITG-L 339
+ V T + C ASG P P I W KD P L ++S I G L
Sbjct: 133 QLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGAL 192
Query: 340 TISDLRTEDSGTYICEVTNTFGSAEATGILMVID--------PLHVTLTPKKLKTGIGST 391
I D G Y C TN+ G+ + + + P ++ P + G +
Sbjct: 193 QIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGS 252
Query: 392 VILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRK 451
V ++C GSP ++W E + P++ + I L + ++S + Y C A
Sbjct: 253 VNITCVAVGSPMPYVKWMLGAEDLTPEDDMPI---GRNVLELNDVRQSAN--YTCVAMST 307
Query: 452 AQTAQDFAIIALE-----DGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDE 506
+ A I ++ GTP + S + + + G P P + + +
Sbjct: 308 LGVIEAIAQITVKALPKPPGTPVVTESTATSIT--------LTWDSGNPEPVSYYIIQHK 359
Query: 507 PIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPP 566
P + Y DG + +V G +R A N +G RGPP
Sbjct: 360 P-----KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIG----------RGPP 404
Query: 567 S 567
S
Sbjct: 405 S 405
Score = 60.1 bits (144), Expect = 2e-08
Identities = 88/341 (25%), Positives = 122/341 (35%), Gaps = 44/341 (12%)
Query: 374 PLHVTLTPKKLKTGI-GSTVILSCALTGSPEFTIRWYRNTELVLPD--EAISIRGLSNET 430
P T TP +TG+ G C TG P I W + + V E I S
Sbjct: 23 PPRFTRTPVD-QTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSV 81
Query: 431 LLITSAQKSHSGA-YQCFATRKAQ--TAQDFAIIALED----GTPRIVSSFSEKVVNPGE 483
L I + A Y+C A+ + + ED G P I KVV
Sbjct: 82 LRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTR 141
Query: 484 QFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSD---GTTI-SHMNVTGPQIRD 539
+++CAA G P P +TW D P+ ++ + S+ GT I + + + D
Sbjct: 142 TATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESD 201
Query: 540 GGVYRCTARNLVGSAEYQARINV---------RGPPSIR-AMRNITAVAGRDTLINCRVI 589
G Y C A N G+ Y A N+ R PP N + G I C +
Sbjct: 202 QGKYECVATNSAGT-RYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAV 260
Query: 590 GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSV 649
G P +KW A L + N L+L DV++ Y C V + I
Sbjct: 261 GSPMPYVKWMLGAEDLTPEDDMPIGRN-VLELNDVRQ---SANYTC-VAMSTLGVIEAIA 315
Query: 650 HVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITW 690
+ VK P PP + P V S I +TW
Sbjct: 316 QITVKALPK------PPGT-------PVVTESTATSITLTW 343
>gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo
sapiens]
Length = 1183
Score = 229 bits (583), Expect = 3e-59
Identities = 259/1067 (24%), Positives = 424/1067 (39%), Gaps = 119/1067 (11%)
Query: 352 YICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN 411
++C++ SA + +V P +PK +++ C G P + W RN
Sbjct: 22 FLCQMI----SALEVPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRN 77
Query: 412 -TELVLPDEAISIRGLSNETLLIT----SAQKSHSGAYQCFATRKAQTAQDFAIIALEDG 466
T + + + TL+I +++ G YQC A + A I+
Sbjct: 78 GTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSR 137
Query: 467 TPRIVSSFSEKV-VNPGEQFSLMCAAK-GAPPPTVTWALDDEPIVRDGSHRTNQYTMSDG 524
+P E + + G+ L C G PPP + W +D+ S R +Q D
Sbjct: 138 SPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFW-MDNSFQRLPQSERVSQGLNGD- 195
Query: 525 TTISHMNVTGPQIRDGGVYRCTAR-----------------------------NLVGSAE 555
+ NV R+ Y C AR NL +
Sbjct: 196 --LYFSNVLPEDTRED--YICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEF 251
Query: 556 YQARINVRGPPSIRAMR----NITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQ 611
Y A+ + PP+ N + G + C G P I W K+ +LP N +
Sbjct: 252 YGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKN--R 309
Query: 612 VVFEN--GTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLI----QPFEFP 665
V++N TL++ V + D G Y C + +I ++ V VK P Q
Sbjct: 310 TVYKNFEKTLQIIHVSEA-DSGNYQC-IAKNALGAIHHTISVRVKAAPYWITAPQNLVLS 367
Query: 666 PASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNG 725
P G L+ C + P RI+W +G V I + K ++ S+V + +
Sbjct: 368 PGEDGTLI---CRANGNPKP-RISWLTNG-VPIEIAPDDPSRKIDGDTIIFSNVQERSSA 422
Query: 726 NYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQ--DGIYGKAGVLNCSVDGYPPPKVMW 783
Y C ASN + + V P ++ P N I + +L+C+ G P P + W
Sbjct: 423 VYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEW 482
Query: 784 -KHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEED-IGYYLCQASNGVGTDISKSM 841
K AKGS + + + G ++I V ++D G Y C A N +G +
Sbjct: 483 FKGAKGSALHEDIYVLHENGTLEI---------PVAQKDSTGTYTCVARNKLGM-AKNEV 532
Query: 842 FLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPI--IIRWEKGDTVIDPDRVMRYAI 899
L +K P I P + +G C + + + + W K + + D R+ +
Sbjct: 533 HLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDE--RFTV 590
Query: 900 ATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP-ELEIREV 958
KD+ L + DS ++C A + L+V + P+PP +LE+ +
Sbjct: 591 -DKDH-------LVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQ 642
Query: 959 KARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVY 1018
+S+ L WT D NS IT F IEY++ +S T A + L P Y
Sbjct: 643 LDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQL-KLSPYVNY 701
Query: 1019 SIRMYSFNKIGRSEPSKELT-ISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNG 1077
S R+ + N IG+S PS+ T+ + PD P V ++ +TWK NG
Sbjct: 702 SFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNG 761
Query: 1078 VIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPS 1137
Y++ +R+ G + S+V + Y + F Y + VQA N G P
Sbjct: 762 PGLQYKVSWRQKD-GDDEWTSVV----VANVSKYIVSGTPTFVPYLIKVQALNDMGFAPE 816
Query: 1138 SSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDG 1197
+ + + ED+P P NVR + S +A + W P ++ G L+GYR+ +W
Sbjct: 817 PAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSS 876
Query: 1198 EWG----EMQNITTTRERVE--LRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP 1251
+ E + +T + L G+E F++Y++ V G+G S T E VP
Sbjct: 877 KRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVP 936
Query: 1252 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSP------ 1305
P+ +K V + S+ + W PP+ PNG++ +YT+ QP S +E P
Sbjct: 937 SAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTL------KYQPINSTHELGPLVDLKI 990
Query: 1306 --EQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPA 1350
+ + + +LN +Y + A TSAG G+ + + +A A
Sbjct: 991 PANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEAMA 1037
Score = 122 bits (306), Expect = 4e-27
Identities = 142/569 (24%), Positives = 222/569 (39%), Gaps = 52/569 (9%)
Query: 103 VVVPCPAAGSPSAALRWYL-ATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDY 161
+V+ C A G P + W T DI P + GTL + S ++ + Y
Sbjct: 58 IVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETY--EGVY 115
Query: 162 FCTAENAAGKIRSPNIRVKAVFREPYTV-RVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 220
CTA N G S NI V+ +T ++E G V C P + ++
Sbjct: 116 QCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPP--PIIF 173
Query: 221 WEKDTVSIIPE-HRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSN------- 272
W ++ +P+ R +G LY S+V ED Y C + ++ +Q
Sbjct: 174 WMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVI 233
Query: 273 ---------GARLSVTD------PAESIPTILD---GFHSQEVWAGHTVELPCTASGYPI 314
A LS T+ E PT L ++E G+ + L C A G P
Sbjct: 234 SVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPT 293
Query: 315 PAIRWLKDGRPLPADSRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVID 373
P I W K+ LP + K L I + DSG Y C N G+ T + V
Sbjct: 294 PIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKA 353
Query: 374 PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN--TELVLPDEAISIRGLSNETL 431
+ P+ L G L C G+P+ I W N + PD+ R + +T+
Sbjct: 354 APYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDD--PSRKIDGDTI 411
Query: 432 LITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKV-VNPGEQFSLMCA 490
+ ++ Q+ S YQC A+ + A + + PRI++ + V L CA
Sbjct: 412 IFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCA 471
Query: 491 AKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNL 550
G+P PT+ W + + + Y + + T + + Q G Y C ARN
Sbjct: 472 FFGSPLPTIEWFKG----AKGSALHEDIYVLHENGT---LEIPVAQKDSTGTYTCVARNK 524
Query: 551 VGSAEYQARINVRGPPSIRAMRNITAVAGRDTLIN--CRVIGYPYYS--IKWYKDALLLP 606
+G A+ + + ++ P I + AV R ++++ C+V S + W KD LP
Sbjct: 525 LGMAKNEVHLEIKDPTWI-VKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELP 583
Query: 607 DNHRQVVFENGTLKLTDVQKGMDEGEYLC 635
+ R V + L + DV D G Y C
Sbjct: 584 SDERFTV-DKDHLVVADVSDD-DSGTYTC 610
Score = 67.4 bits (163), Expect = 1e-10
Identities = 69/308 (22%), Positives = 115/308 (37%), Gaps = 22/308 (7%)
Query: 70 LDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYD 129
L ++H V + Y++ V G ++ C A G+P + W L G I
Sbjct: 340 LGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLI-CRANGNPKPRISW-LTNGVPIEI 397
Query: 130 VPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTV 189
P +G ++ ++ Y C A N G + + N V + P +
Sbjct: 398 APDDPSRKIDGDTIIFSNVQERSSAV-----YQCNASNEYGYLLA-NAFVNVLAEPPRIL 451
Query: 190 RVEDQ--RSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDV 247
+ + + A+ C S + + W K ++ + G V
Sbjct: 452 TPANTLYQVIANRPALLDCAFFGSP---LPTIEWFKGAKGSALHEDIYVLHENGTLEIPV 508
Query: 248 QKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPC 307
++D+ TY C+ ++K N L + DP I+ V G V C
Sbjct: 509 AQKDSTGTYTCVARNKLG---MAKNEVHLEIKDPT----WIVKQPEYAVVQRGSMVSFEC 561
Query: 308 TASGYPIPAIR--WLKDGRPLPADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEA 365
++ WLKD R LP+D R+T L ++D+ +DSGTY C T S A
Sbjct: 562 KVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSA 621
Query: 366 TGILMVID 373
+ +L V+D
Sbjct: 622 SAVLSVVD 629
Score = 50.1 bits (118), Expect = 2e-05
Identities = 60/272 (22%), Positives = 107/272 (39%), Gaps = 49/272 (18%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNT 1428
L C G P P ++W K ++ SA+ + ++H NGTL + + + +G YTC A N
Sbjct: 468 LDCAFFGSPLPTIEWFKGAKGSALHEDI---YVLHENGTLEIPVAQKDSTGTYTCVARNK 524
Query: 1429 GGFDTIIVNLLVQVPP---DQPRLTVSKTSAS-------------SITLTWIPGDNGGSS 1472
G V+L ++ P QP V + + S+T+ W+ + S
Sbjct: 525 LGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPS 584
Query: 1473 IRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEA 1532
F + KD + + + GT+ V +SV + + +++
Sbjct: 585 DERFTVD---------KDHLVVAD-----VSDDDSGTYTCVANTTLDSVSASAVLSVVDV 630
Query: 1533 KTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEY----RPKGTWAWQGL 1588
P+ D L ++ + +L+ ++ PIT ++EY G W Q
Sbjct: 631 ------PNPPFDLELTDQLDKS-VQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQ-- 681
Query: 1589 RANSSGEVFLTELREATW--YELRMRACNSAG 1618
SG +L+ + + Y R+ A NS G
Sbjct: 682 -TEVSGTQTTAQLKLSPYVNYSFRVMAVNSIG 712
Score = 45.8 bits (107), Expect = 4e-04
Identities = 91/456 (19%), Positives = 165/456 (36%), Gaps = 51/456 (11%)
Query: 1148 DVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFW-SLYVDGEWGEMQNIT 1206
DVP+ PP ++ +SW+ P N + + + + +++ G W ++
Sbjct: 629 DVPN-PPFDLELTDQLDKSVQLSWT--PGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVS 685
Query: 1207 TTRERVELRGMEKFTNYSVQVLAYTQAGDGVRS--SVLYIQTKEDVPGPPAGIKAVPSSA 1264
T+ +L+ + + NYS +V+A G + S S Y+ + P ++ + S
Sbjct: 686 GTQTTAQLK-LSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEP 744
Query: 1265 SSVVVSWLPPT--KPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYL 1322
++V++W P + NG +Y + S + + Y ++ YL
Sbjct: 745 DNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSK--YIVSGTPTFVPYL 802
Query: 1323 LWVAAVTSAG--------RGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSV 1374
+ V A+ G G+S E + + G +++ T+ V P S+
Sbjct: 803 IKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVN--STLAEVHWDPV--PLKSI 858
Query: 1375 GDPAPAVK---WTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG- 1430
+ W S ++ L E +YT G
Sbjct: 859 RGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGK 918
Query: 1431 -----FDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNS 1485
+ N VP L + + S+TL W P + + + L+Y NS
Sbjct: 919 GEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQPINS 978
Query: 1486 EE----WKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSG-RISEIIEAKTHGREPS 1540
D+ I +++ + L +L T YK A+ S GSG +I+E EA T E
Sbjct: 979 THELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITE--EAVTTVDEAM 1036
Query: 1541 FSKDQHLFTHINSTHARLNLQGWNNG-GCPITAIVL 1575
S+ + T QGW G C + ++L
Sbjct: 1037 ASRQVDIAT-----------QGWFIGLMCAVALLIL 1061
Score = 36.6 bits (83), Expect = 0.27
Identities = 22/85 (25%), Positives = 38/85 (44%), Gaps = 4/85 (4%)
Query: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
+D L C + G+P P + W + I ++ D T++ V+ S Y C
Sbjct: 370 EDGTLICRANGNPKPRISWL--TNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCN 427
Query: 1425 ATNTGGFDTIIVNLLVQVPPDQPRL 1449
A+N G+ ++ N V V + PR+
Sbjct: 428 ASNEYGY--LLANAFVNVLAEPPRI 450
Score = 34.3 bits (77), Expect = 1.3
Identities = 25/78 (32%), Positives = 36/78 (46%), Gaps = 8/78 (10%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTN--GTLLLRAVKAEDSGYYTCTAT 1426
L C + G P P + W K ED +P + R ++ N TL + V DSG Y C A
Sbjct: 284 LECIAEGLPTPIIYWAK--EDGMLPKN----RTVYKNFEKTLQIIHVSEADSGNYQCIAK 337
Query: 1427 NTGGFDTIIVNLLVQVPP 1444
N G +++ V+ P
Sbjct: 338 NALGAIHHTISVRVKAAP 355
Score = 32.0 bits (71), Expect = 6.6
Identities = 27/96 (28%), Positives = 42/96 (43%), Gaps = 13/96 (13%)
Query: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT---NGTLLLRAV---KAED- 1417
+++ + C + G P P+ WT++ +D L+ GTL++ + KAE
Sbjct: 56 ENIVIQCEAKGKPPPSFSWTRNGTH----FDIDKDPLVTMKPGTGTLIINIMSEGKAETY 111
Query: 1418 SGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSK 1453
G Y CTA N G + N +V P P T K
Sbjct: 112 EGVYQCTARNERG--AAVSNNIVVRPSRSPLWTKEK 145
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 228 bits (582), Expect = 4e-59
Identities = 217/840 (25%), Positives = 357/840 (42%), Gaps = 80/840 (9%)
Query: 464 EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI--VRDGSHRTNQYTM 521
ED PRIV + +V+ GE +L C A+G P P + W + + VR+ R ++ +
Sbjct: 60 EDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDP-RAHRLLL 118
Query: 522 SDGTTISHMNVTGPQIR-DGGVYRCTARNLVGSAEYQ---ARINVRGPPSIRAMRNITAV 577
G V G + R D GVY C ARN +G+A + + V ++ N+
Sbjct: 119 PSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVA 178
Query: 578 AGRDTLINC-RVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC- 635
G ++ C G+P S+ W KD L + ++ G L ++ K D G Y+C
Sbjct: 179 VGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKS-DAGMYVCV 237
Query: 636 -SVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDG 694
S + + S + V V + L +P + + ++ C V GD P R+ WRK+
Sbjct: 238 ASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFL-CEVK-GDPPPRLRWRKED 295
Query: 695 QVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVV 754
+ +G I S SL I VS + G YTC+A N+ L V VPP+ V
Sbjct: 296 GELPTGR-YEIRSDH---SLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVT 351
Query: 755 QPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLI 814
QP +Q G++ C G PPP + W+ + TGR + P L I
Sbjct: 352 QPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNI 411
Query: 815 RHVLEEDIGYYLCQASNGVGTDISKSMFLTVK------IPAMITSHPNTTIAIKGHAKEL 868
V D GYY+CQA + G+ ++K++ L +K +P +I P + G + L
Sbjct: 412 TAVQRGDAGYYVCQAVSVAGSILAKAL-LEIKGASLDGLPPVILQGPANQTLVLGSSVWL 470
Query: 869 NCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCH 928
C G +RW+K + D + T NG TL + D F+SC
Sbjct: 471 PCRVTGNPQPSVRWKKDGQWLQGDDLQ---FKTMANG-----TLYIANVQEMDMGFYSCV 522
Query: 929 AINSYG-----------EDRGLIQLTVQEPPDPP----ELEIREVKARSMNLRWTQRFDG 973
A +S G ED G+ EP PP + + E+ S+ L W
Sbjct: 523 AKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQT 582
Query: 974 NSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEP 1033
+ +T + IE + + ++ + + + L P ++Y + + G SEP
Sbjct: 583 GAAVTSYVIEAFSPAAGNTWRTVADGVQ--LETHTVSGLQPNTIYLFLVRAVGAWGLSEP 640
Query: 1034 SK-ELTISTEEAAPDGPPMD------------VTLQ-PVT--SQSIQVTWKAPKKELQNG 1077
S + T++++P P D V LQ P+ +++QV+W +
Sbjct: 641 SPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTV---DGPVQ 697
Query: 1078 VIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPS 1137
+++G+++ +R P G ++++++++ L L Q + VQA + G G
Sbjct: 698 LVQGFRVSWRVAGP-EGGSWTMLDLQSPSQQST-VLRGLPPGTQIQIKVQAQGQEGLGAE 755
Query: 1138 SSEINATTLEDVPSQPPENVRALSITSD---VAVISWSEPPRSTLNGVLKGYRVIFWSLY 1194
S + + E+ PS PP+ V A+++ D +SW P S NGV+ Y++ W L
Sbjct: 756 SLSVTRSIPEEAPSGPPQGV-AVALGGDGNSSITVSWEPPLPSQQNGVITEYQI--WCLG 812
Query: 1195 VDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPP 1254
+ + ++ LRG+ Y V A T AG GV S+ + +Q +P PP
Sbjct: 813 NESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQ----LPSPP 868
Score = 177 bits (449), Expect = 1e-43
Identities = 223/864 (25%), Positives = 358/864 (41%), Gaps = 128/864 (14%)
Query: 551 VGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLL----- 605
VG + RI V PP + R G + CR G P +I+WYK+ +
Sbjct: 57 VGPEDAMPRI-VEQPPDLLVSR------GEPATLPCRAEGRPRPNIEWYKNGARVATVRE 109
Query: 606 -PDNHRQVVFENGTLKLTDVQKGM----DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQ 660
P HR ++ +G L + G DEG Y C + + L + S + +++V L
Sbjct: 110 DPRAHR-LLLPSGALFFPRIVHGRRARPDEGVYTC--VARNYLGAAASRNASLEVAVLRD 166
Query: 661 PFEFPPASI----GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSG-VTIESKEFMSSLQ 715
F P ++ G+ + CV G ++WRKDG + G +TI + M S
Sbjct: 167 DFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHT 226
Query: 716 ISSVSLKHNGNYTCIASNAAAT-VSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVD 774
+ S + G Y C+ASN A S +++V P F+ +P NQ + C V
Sbjct: 227 LKSDA----GMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVK 282
Query: 775 GYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVG 834
G PPP++ W+ G +P TGR +I + SL I HV ED G Y C A N VG
Sbjct: 283 GDPPPRLRWRKEDGE--------LP-TGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVG 333
Query: 835 TDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEK--GDTVIDPD 892
S L+V +P + + P +A G + C +G P I W+K ++ P
Sbjct: 334 R-AEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPS 392
Query: 893 RVM----RYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDR----------- 937
+ + R++++ + L + RGD+ ++ C A++ G
Sbjct: 393 QSLQPTGRFSVSPRGQ-------LNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGAS 445
Query: 938 --GLIQLTVQEPPDPPE-------LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKS 988
GL + +Q P + L R ++RW + DG + G D+++K +
Sbjct: 446 LDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKK--DGQWL-QGDDLQFKTMA 502
Query: 989 DSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKI---GRSEPSKELTIS----T 1041
+ T+ AN+ ++ + S + G + ++ +S T
Sbjct: 503 NG------------TLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPT 550
Query: 1042 EEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVE 1101
E ++P G P + +T SI +TWK + + Y I SP + + V
Sbjct: 551 EPSSPPGAPSQPVVTEITKNSITLTWKPNPQT--GAAVTSYVI--EAFSPAAGNTWRTV- 605
Query: 1102 MKATG-DSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINATTLEDVPSQPPENV-R 1158
A G E +T+ L+ Y +V+A G PS T + PS+P E+ R
Sbjct: 606 --ADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWR 663
Query: 1159 ALSITSDVAVISWSEP----PRS-----TLNG---VLKGYRVIFWSLY--VDGEWGEMQN 1204
++VAV EP PR+ T++G +++G+RV W + G W +
Sbjct: 664 GQQGLAEVAV-RLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVS-WRVAGPEGGSWTMLDL 721
Query: 1205 ITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP-GPPAGIKAV--P 1261
+ +++ LRG+ T ++V A Q G G S + E+ P GPP G+
Sbjct: 722 QSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGG 781
Query: 1262 SSASSVVVSWLPP--TKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQ 1319
SS+ VSW PP ++ NGVI +Y I+C G+ + + L G
Sbjct: 782 DGNSSITVSWEPPLPSQQNGVITEYQIWCL--GNESRFHLNRSAAGWARSAMLRGLVPGL 839
Query: 1320 QYLLWVAAVTSAGRGNSSEKVTIE 1343
Y VAA TSAG G S V ++
Sbjct: 840 LYRTLVAAATSAGVGVPSAPVLVQ 863
Score = 135 bits (339), Expect = 6e-31
Identities = 136/531 (25%), Positives = 219/531 (41%), Gaps = 67/531 (12%)
Query: 272 NGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP------ 325
NG+R+ P +++P I++ V G LPC A G P P I W K+G
Sbjct: 53 NGSRVG---PEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVRE 109
Query: 326 --------LPADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH- 376
LP+ + + RI D G Y C N G+A + + + L
Sbjct: 110 DPRAHRLLLPSGALFFPRIVH---GRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRD 166
Query: 377 -VTLTPKKLKTGIGSTVILSCA-LTGSPEFTIRWYRNTELVLPDEA-ISIRGLSNETLLI 433
+P + +G +L C G PE ++ W ++ + +E I+IRG L++
Sbjct: 167 DFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRG---GKLMM 223
Query: 434 TSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKG 493
+ KS +G Y C A+ A + A + P + +VV + +C KG
Sbjct: 224 SHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKG 283
Query: 494 APPPTVTWALDDEPIVRDGSHRTNQYTMSDGTT--ISHMNVTGPQIRDGGVYRCTARNLV 551
PPP + W + DG T +Y + + I H++ D G Y C A N V
Sbjct: 284 DPPPRLRWRKE------DGELPTGRYEIRSDHSLWIGHVSA-----EDEGTYTCVAENSV 332
Query: 552 GSAEYQARINVRGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKD---ALLLPD 607
G AE ++V PP + ++ A G C G P +I W K+ LL P
Sbjct: 333 GRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPS 392
Query: 608 NHRQ-----VVFENGTLKLTDVQKGMDEGEYLC-------SVLIQPQLSISQSVHVAVKV 655
Q V G L +T VQ+G D G Y+C S+L + L I + +
Sbjct: 393 QSLQPTGRFSVSPRGQLNITAVQRG-DAGYYVCQAVSVAGSILAKALLEI-KGASLDGLP 450
Query: 656 PPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMS-SL 714
P ++Q +G +++PC V+ P + W+KDGQ + G ++ K + +L
Sbjct: 451 PVILQGPANQTLVLGSSVWLPCRVTGNPQP-SVRWKKDGQWL---QGDDLQFKTMANGTL 506
Query: 715 QISSVSLKHNGNYTCIASNAAATVSRERQLIVR----VPPRFVVQPNNQDG 761
I++V G Y+C+A ++ + L +R V P +P++ G
Sbjct: 507 YIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPG 557
Score = 133 bits (335), Expect = 2e-30
Identities = 130/478 (27%), Positives = 193/478 (40%), Gaps = 40/478 (8%)
Query: 105 VPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIH------- 157
+PC A G P + WY G + V H L P F +H
Sbjct: 83 LPCRAEGRPRPNIEWY-KNGARVATVREDPRAHR----LLLPSGALFFPRIVHGRRARPD 137
Query: 158 DNDYFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYV 216
+ Y C A N G S N ++ AV R+ + + G AV +C+ P E
Sbjct: 138 EGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPE-- 195
Query: 217 SVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARL 276
VSW KD + E G L +S K DA Y C+ + +GE R+S A +
Sbjct: 196 PSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDA-GMYVCVASNM-AGE-RESAAAEV 252
Query: 277 SVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI 336
V + P+ L +Q V A V C G P P +RW K+ LP +
Sbjct: 253 MVLER----PSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSD 308
Query: 337 TGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSC 396
L I + ED GTY C N+ G AEA+G L V P + P+ G +V C
Sbjct: 309 HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQC 368
Query: 397 ALTGSPEFTIRWYRNTELVL--PDEAISIRGLSNET----LLITSAQKSHSGAYQCFATR 450
G+P I W + VL P +++ G + + L IT+ Q+ +G Y C A
Sbjct: 369 ETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVS 428
Query: 451 KAQTAQDFAIIALE----DGTPRIV-SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDD 505
A + A++ ++ DG P ++ + + + G L C G P P+V W D
Sbjct: 429 VAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDG 488
Query: 506 EPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR 563
+ + D TM++GT + + Q D G Y C A++ G A + + +R
Sbjct: 489 QWLQGDD---LQFKTMANGT----LYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMR 539
Score = 65.5 bits (158), Expect = 5e-10
Identities = 89/387 (22%), Positives = 147/387 (37%), Gaps = 51/387 (13%)
Query: 1312 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGK--APAKIISFGGTVTTPWMKDVRL 1369
I + RG AV+ AG + + I+ A P I+ T V L
Sbjct: 411 ITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWL 470
Query: 1370 PCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRL---IHTNGTLLLRAVKAEDSGYYTCTAT 1426
PC G+P P+V+W KD + + G L NGTL + V+ D G+Y+C A
Sbjct: 471 PCRVTGNPQPSVRWKKDGQ------WLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAK 524
Query: 1427 NTGGFDTIIVNLLVQ----VPPDQP-----------RLTVSKTSASSITLTWIPGDNGGS 1471
++ G T L ++ V PD P + V++ + +SITLTW P G+
Sbjct: 525 SSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGA 584
Query: 1472 SIRGFVLQ-YSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEII 1530
++ +V++ +S W+ V + + L+ T Y + A + G S +
Sbjct: 585 AVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVS 644
Query: 1531 E-AKTHGREPSFSKDQHLFTHINSTHARLNLQ------------GWNNGGCPITAIVLEY 1577
E +T PS + + LQ W G P+ +V +
Sbjct: 645 EPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDG-PV-QLVQGF 702
Query: 1578 RPK--------GTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCGNETAQFA-T 1628
R G+W L++ S L L T +++++A G G E+ +
Sbjct: 703 RVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRS 762
Query: 1629 LDYDGSTIPPIKSAQGEGDDVKKLFTI 1655
+ + + PP A G D T+
Sbjct: 763 IPEEAPSGPPQGVAVALGGDGNSSITV 789
Score = 48.9 bits (115), Expect = 5e-05
Identities = 29/74 (39%), Positives = 38/74 (51%), Gaps = 5/74 (6%)
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
C GDP P ++W K ED +P G I ++ +L + V AED G YTC A N+ G
Sbjct: 279 CEVKGDPPPRLRWRK--EDGELPT---GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVG 333
Query: 1431 FDTIIVNLLVQVPP 1444
+L V VPP
Sbjct: 334 RAEASGSLSVHVPP 347
Score = 46.6 bits (109), Expect = 3e-04
Identities = 34/153 (22%), Positives = 64/153 (41%), Gaps = 11/153 (7%)
Query: 1294 GQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKII 1353
G+ YE + + I H++ + A S GR +S +++ P +++
Sbjct: 296 GELPTGRYEIRSDHSLW-IGHVSAEDEGTYTCVAENSVGRAEASGSLSVH----VPPQLV 350
Query: 1354 SFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMD----GHRLIHTNGTLL 1409
+ + V C + G+P PA+ W K+ + S G + G L
Sbjct: 351 TQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLN 410
Query: 1410 LRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQV 1442
+ AV+ D+GYY C A + G +I+ L+++
Sbjct: 411 ITAVQRGDAGYYVCQAVSVAG--SILAKALLEI 441
Score = 36.6 bits (83), Expect = 0.27
Identities = 20/65 (30%), Positives = 30/65 (46%), Gaps = 6/65 (9%)
Query: 1369 LPCNSVGDPAPAVKWTKD-SEDSAIPVSMDGHRLIHTNGTLLLRAV-----KAEDSGYYT 1422
LPC + G P P ++W K+ + + + HRL+ +G L + D G YT
Sbjct: 83 LPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYT 142
Query: 1423 CTATN 1427
C A N
Sbjct: 143 CVARN 147
Score = 35.0 bits (79), Expect = 0.78
Identities = 34/154 (22%), Positives = 61/154 (39%), Gaps = 8/154 (5%)
Query: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG-FDT 1433
G P P+V W KD + + R+ G L++ D+G Y C A+N G ++
Sbjct: 192 GHPEPSVSWRKDGAR----LKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERES 247
Query: 1434 IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFI 1493
++V P R V++ + +T++ G R L++ ++ E +
Sbjct: 248 AAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPR---LRWRKEDGELPTGRYE 304
Query: 1494 SSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRIS 1527
S+ S + + A+NSVG S
Sbjct: 305 IRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEAS 338
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 226 bits (576), Expect = 2e-58
Identities = 260/1015 (25%), Positives = 419/1015 (41%), Gaps = 106/1015 (10%)
Query: 680 SSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS-LQISSVSL-KHNGNYTCIASNAAAT 737
++GD +I W K G+ + + IE + S L+I + + Y C+ASN
Sbjct: 47 ATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGE 106
Query: 738 VSRERQLIV----RVP---PRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSG 790
+S +L V ++P P + P + + + C+ G P P++ W
Sbjct: 107 ISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWF------ 160
Query: 791 NPQQYHPVPLT---GRIQILPNSS---------LLIRHVLEEDIGYYLCQASNGVGTDIS 838
+ + PV + GRI+ L + S L I E D G Y C A+N GT S
Sbjct: 161 --KDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYS 218
Query: 839 KSMFLTVK-------IPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP 891
L V+ +P + P + G + + C A G ++W G + P
Sbjct: 219 APANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTP 278
Query: 892 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP 951
+ D + L+ D S ++C A+++ G + Q+TV+ P PP
Sbjct: 279 E------------DDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPP 326
Query: 952 ELEI-REVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIV 1010
+ E A S+ L W GN + I +S + + ++ T + ++
Sbjct: 327 GTPVVTESTATSITLTWDS---GNPEPVSYYIIQHKPKNSEELYKEIDGVATT--RYSVA 381
Query: 1011 DLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAP 1070
L P S Y R+ + N IGR PS+ + T E AP P DV + ++S +I V WK P
Sbjct: 382 GLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEP 441
Query: 1071 KKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFN 1130
E NG I+GY++ Y + + DS++ T+ NL Y V V AF
Sbjct: 442 --EEPNGQIQGYRVYYTMDPTQHVNNWM---KHNVADSQITTIGNLVPQKTYSVKVLAFT 496
Query: 1131 RAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIF 1190
G GP SS+I T VP Q P N +A + ++SW+ PPRS + Y ++
Sbjct: 497 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWT-PPRS---DTIANYELV- 550
Query: 1191 WSLYVDGEWGEMQNIT-TTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKED 1249
Y DGE GE Q IT L+G++ + Y ++ A + G G ++ + +T +
Sbjct: 551 ---YKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607
Query: 1250 VP-GPPAGIKAVPSSASSVVVSWLPP--TKPNGVIRKYTIFCSSPGSGQPAPSEYETSP- 1305
P PP I S++S++VSW PP K NG+I +Y+I ++ P E P
Sbjct: 608 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPS 667
Query: 1306 EQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTI---EPAGKAPAKIISFGGTVTTP 1362
+ Y + L + +Y + V A T G G S V I E P + + +T
Sbjct: 668 DTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS 727
Query: 1363 WMKDVRLPCNSV------GDPAPAVKWTKDSEDSAIPVSMDGHRL-------IHTNGTLL 1409
R P + G V+ ++ E P+ D T ++
Sbjct: 728 VKVSWRSPVPNKQHGQIRGYQVHYVR-MENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI 786
Query: 1410 LRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP---PDQPRLTVSKTSASSITLTWIPG 1466
+ ++ E S T TA T G LV P +PRL ++ T ++ + W P
Sbjct: 787 ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPP 846
Query: 1467 DNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRI 1526
+ ++G+ L++ + E + S E F + G Y +L+A+N VG G
Sbjct: 847 VDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG-- 904
Query: 1527 SEIIEAKTHGREPSFSKDQHLFTH-INSTHARLNLQ----GWNNGGCPITAIVLEYRPKG 1581
E+++ + E Q+L + ST +L+ Q NG IT L YR
Sbjct: 905 EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNG--IITKYTLLYRDIN 962
Query: 1582 --TWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCG--NETAQFATLDYD 1632
+ L + + LT L+ T Y++++RA S G G + + QF TL D
Sbjct: 963 IPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVD 1017
Score = 220 bits (560), Expect = 1e-56
Identities = 264/1091 (24%), Positives = 438/1091 (40%), Gaps = 159/1091 (14%)
Query: 547 ARNLVGSAEYQARINVRGPPSI-RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLL 605
AR L+ + R + PP R + T V+G C+ G P I W K +
Sbjct: 5 ARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKV 64
Query: 606 PDNHRQVV-FENGT---LKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQP 661
+ +V+ F++G+ L++ ++ DE Y C V IS S + V I P
Sbjct: 65 SNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYEC-VASNNVGEISVSTRLTVLREDQI-P 122
Query: 662 FEFPPASIGQLLYIP--------CVVSSGDMPIRITWRKDGQVIISGSG---------VT 704
FP +G L + +SG+ ITW KD + + + +
Sbjct: 123 RGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSES 182
Query: 705 IESKEFMSSLQISSVSLKHNGNYTCIASNAAAT--------VSRERQLIVRVPPRFVVQP 756
I +LQI G Y C+A+N+A T RE + + RVPPRF + P
Sbjct: 183 IGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPP 242
Query: 757 NNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRH 816
N + + G + + C G P P V W P+ P+ R+
Sbjct: 243 TNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIG---------------RN 287
Query: 817 VLE----EDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTA 872
VLE Y C A + +G I +TVK + P T + + A + T
Sbjct: 288 VLELNDVRQSANYTCVAMSTLGV-IEAIAQITVKA---LPKPPGTPVVTESTATSITLT- 342
Query: 873 RGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEV-------VSTLKLKPADRG--DSV 923
W+ G+ P+ V Y I K E V+T + A
Sbjct: 343 ---------WDSGN----PEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDY 389
Query: 924 FFSCHAINSYGE----DRGLIQLTVQEPPDPP-ELEIREVKARSMNLRWTQRFDGNSIIT 978
F A+N+ G + L Q + Q P P +++ R + + ++ ++W + + N I
Sbjct: 390 EFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQ 449
Query: 979 GFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELT 1038
G+ + Y N++ + I +L P YS+++ +F IG S ++
Sbjct: 450 GYRVYYTMDPTQHVNNWMKHNVADS-QITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQ 508
Query: 1039 ISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYS 1098
+ T+ P G P++ +P + SI ++W P+ + I Y++ Y++ G + +
Sbjct: 509 VITQTGVP-GQPLNFKAEPESETSILLSWTPPRSD----TIANYELVYKDGEHGEEQRIT 563
Query: 1099 IVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVR 1158
I G S Y L LK + Y + A + G G S++EI+A T++ PS PP+++
Sbjct: 564 I----EPGTS--YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDIS 617
Query: 1159 ALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWG---EMQNITTTRERVELR 1215
S +S ++SW PP NG++ Y + + + VDGE E+ I + + L
Sbjct: 618 CTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA--VDGEDDKPHEILGIPSDTTKYLLE 675
Query: 1216 GMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP-GPPAGIKAVPSSASSVVVSWLPP 1274
+EK+T Y + V A+T G G S + I+T EDVP GPP ++ +++SV VSW P
Sbjct: 676 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSP 735
Query: 1275 T--KPNGVIRKYTIFCSSPGSGQP-------------APSEYETSPEQLFYRIAHLNRGQ 1319
K +G IR Y + +G+P A E++ + E I+ L
Sbjct: 736 VPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI-ISGLQPET 794
Query: 1320 QYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAP 1379
Y L V A T+ G G S+ + G P K RL N
Sbjct: 795 SYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK---------------PRLVINHTQMNTA 839
Query: 1380 AVKWTKDSEDSAIPVSMDGHRLIHTNGTL--LLRAVKAEDSGYYTCT------------- 1424
++W + + G+RL + L +E ++T T
Sbjct: 840 LIQWHPPVDTFG---PLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLS 896
Query: 1425 ATNTGGFDTIIVNLLVQVPPDQP-----RLTVSKTSASSITLTWIP---GDNGGSSIRGF 1476
A N GF +V + +P + P L T+++S+ L+W P + G +
Sbjct: 897 ARNKVGFGEEMVKE-ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYT 955
Query: 1477 VLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHG 1536
+L ++ + I ++ + L LK T Y VK+ A S G G S ++ +T
Sbjct: 956 LLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLP 1015
Query: 1537 REPSFSKDQHL 1547
+ F+K+ H+
Sbjct: 1016 VDQVFAKNFHV 1026
Score = 176 bits (447), Expect = 2e-43
Identities = 241/1075 (22%), Positives = 412/1075 (38%), Gaps = 119/1075 (11%)
Query: 468 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTI 527
PR + ++ G S +C A G P P + W + V + ++ G+ +
Sbjct: 24 PRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKK-VSNQRFEVIEFDDGSGSVL 82
Query: 528 SHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV-------RGPPSIRAMRNITAVAG- 579
+ P RD +Y C A N VG R+ V RG P+I + V
Sbjct: 83 RIQPLRTP--RDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERT 140
Query: 580 RDTLINCRVIGYPYYSIKWYKDALLLPDNH-----RQVVFEN-------GTLKLTDVQKG 627
R + C G P I W+KD L + ++ +Q+ E+ G L++ ++
Sbjct: 141 RTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEES 200
Query: 628 MDEGEYLCSVLIQPQLSISQSVHVAVK-------VPPLIQPFEFPPASI----GQLLYIP 676
D+G+Y C S ++ V+ VPP F PP + G + I
Sbjct: 201 -DQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPR---FSIPPTNHEIMPGGSVNIT 256
Query: 677 CVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAA 736
CV MP + W ++ +T E + + ++ + NYTC+A +
Sbjct: 257 CVAVGSPMPY-VKW------MLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLG 309
Query: 737 TVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWK--HAKGSGNPQQ 794
+ Q+ V+ P+ P A + + D P V + K + +
Sbjct: 310 VIEAIAQITVKALPK---PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEEL 366
Query: 795 YHPVP--LTGRIQIL---PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPA 849
Y + T R + P S R V +IG S V T S+ +
Sbjct: 367 YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRG--PPSEPVLTQTSEQAPSSAPRDV 424
Query: 850 MITSHPNTTIAIKG-HAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEV 908
+TTI ++ +E N +G R D + M++ +A D
Sbjct: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYYTM----DPTQHVNNWMKHNVA-----DSQ 475
Query: 909 VSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQE--PPDPPELEIREVKARSMNLR 966
++T+ + SV G IQ+ Q P P + S+ L
Sbjct: 476 ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLS 535
Query: 967 WTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFN 1026
WT + I +++ YK D ++ I P + + L P S+Y R+ + +
Sbjct: 536 WTP--PRSDTIANYELVYK---DGEHGEEQRITIEPGTSY-RLQGLKPNSLYYFRLAARS 589
Query: 1027 KIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGY 1086
G + E++ T ++ P PP D++ +S SI V+W+ P E QNG+I Y I Y
Sbjct: 590 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649
Query: 1087 RENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTL 1146
+ + I+ + + D+ Y L+ L+K+ +Y + V A G GP S + T
Sbjct: 650 TAVDGEDDKPHEILGIPS--DTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 707
Query: 1147 EDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWS-------------- 1192
EDVPS PP V ++ S +SW P + +G ++GY+V +
Sbjct: 708 EDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKD 767
Query: 1193 -LYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP 1251
+ D +W + TT + + G++ T+YS+ V AYT GDG RS + T VP
Sbjct: 768 VMLADAQW---EFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVP 824
Query: 1252 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAP-SEYETSPEQLFY 1310
G P + + ++ ++ W PP G ++ Y + G P + E S ++ +
Sbjct: 825 GKPR-LVINHTQMNTALIQWHPPVDTFGPLQGYRL---KFGRKDMEPLTTLEFSEKEDHF 880
Query: 1311 RIAHLNRGQQYLLWVAAVTSAGRGNSSEK---VTIEPAGKAPAKIISFGGTVTT---PWM 1364
+++G Y+ ++A G G K + E P + S G T T+ W
Sbjct: 881 TATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQ 940
Query: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAE---DSGYY 1421
V N + K+T D IP+ ++ + T+ L +K + D
Sbjct: 941 PPVLAERNGI-----ITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVR 995
Query: 1422 TCTATNTGGFDTIIVNLLVQVPPDQ---PRLTVSKTSASSITLTWIPGDNGGSSI 1473
T+ G + + +P DQ V +S+ L+W +N S++
Sbjct: 996 AHTSKGPGPYSPSV--QFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAM 1048
Score = 153 bits (386), Expect = 2e-36
Identities = 212/930 (22%), Positives = 367/930 (39%), Gaps = 102/930 (10%)
Query: 749 PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPL-TGRIQIL 807
PPRF P +Q G+ G C G P PK++W + Q++ + G +L
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVL 82
Query: 808 PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTV----KIP---AMITSHPNTTIA 860
L D Y C ASN VG +IS S LTV +IP I P +
Sbjct: 83 RIQPLR----TPRDEAIYECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQLKVV 137
Query: 861 IKGHAKELNCTARGERPIIIRWEKGDTVIDPDR---VMRYAIATKDNGDEVVSTLKLKPA 917
+ + C A G I W K +D ++ + G + L+++ +
Sbjct: 138 ERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQS 197
Query: 918 DRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVK-ARSMNLRWTQRFDGNSI 976
+ D + C A NS G P L +RE++ R + R++ + I
Sbjct: 198 EESDQGKYECVATNSAGTRYSA----------PANLYVRELREVRRVPPRFSIPPTNHEI 247
Query: 977 ITGFDIEYK-----NKSDSWDFKQSTRNISPTINQ---ANIVDLHPA-SVYSIRMYSFNK 1027
+ G + + + +++P + N+++L+ + + +
Sbjct: 248 MPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMST 307
Query: 1028 IGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYR 1087
+G E ++T+ +A P PP + T+ SI +TW + E + Y I ++
Sbjct: 308 LGVIEAIAQITV---KALPK-PPGTPVVTESTATSITLTWDSGNPE----PVSYYIIQHK 359
Query: 1088 ENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLE 1147
+ S Y ++ AT Y++ L ++ Y V A N G GP S + T E
Sbjct: 360 PKN--SEELYKEIDGVAT---TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 414
Query: 1148 DVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITT 1207
PS P +V+A ++S ++ W EP NG ++GYRV + M++
Sbjct: 415 QAPSSAPRDVQARMLSSTTILVQWKEPEEP--NGQIQGYRVYYTMDPTQHVNNWMKHNVA 472
Query: 1208 TRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSV 1267
+ + + YSV+VLA+T GDG SS + + T+ VPG P KA P S +S+
Sbjct: 473 DSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Query: 1268 VVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAA 1327
++SW PP + I Y + G+ + T YR+ L Y +AA
Sbjct: 533 LLSWTPPR--SDTIANYELVYK---DGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 587
Query: 1328 VTSAGRGNSSEKV---TIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWT 1384
+ G G S+ ++ T++ AP + IS T+P + + P P K
Sbjct: 588 RSPQGLGASTAEISARTMQSKPSAPPQDIS----CTSPSSTSILVS----WQPPPVEKQN 639
Query: 1385 KDSEDSAIP-VSMDG-----HRLI---HTNGTLLLRAVKAEDSGYYTCTATNTGGFDTII 1435
+ +I ++DG H ++ LL ++ T TA G
Sbjct: 640 GIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPES 699
Query: 1436 VNLLVQVPPDQP-----RLTVSKTSASSITLTW---IPGDNGGSSIRGFVLQY-SVDNSE 1486
+++L++ D P ++ V +++S+ ++W +P G IRG+ + Y ++N E
Sbjct: 700 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHG-QIRGYQVHYVRMENGE 758
Query: 1487 E-----WKDVFISSSERSFK--------LDSLKCGTWYKVKLAAKNSVGSGRISEIIEAK 1533
KDV ++ ++ F + L+ T Y + + A + G G S+
Sbjct: 759 PKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVS 818
Query: 1534 THGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSS 1593
T G P K + + H A + + P+ L++ K L +
Sbjct: 819 TTGAVP--GKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEK 876
Query: 1594 GEVF-LTELREATWYELRMRACNSAGCGNE 1622
+ F T++ + Y R+ A N G G E
Sbjct: 877 EDHFTATDIHKGASYVFRLSARNKVGFGEE 906
Score = 63.5 bits (153), Expect = 2e-09
Identities = 90/421 (21%), Positives = 145/421 (34%), Gaps = 61/421 (14%)
Query: 177 IRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFI 236
+R A +T DQ + G VA F C + + W K + + I
Sbjct: 16 LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIV---WNKKGKKVSNQRFEVI 72
Query: 237 TYHGG----LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGF 292
+ G L I ++ + Y C+ + + + L PTI G
Sbjct: 73 EFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGP 132
Query: 293 HSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP------------LPADSRWTKRITG-L 339
+ V T + C ASG P P I W KD P L ++S I G L
Sbjct: 133 QLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGAL 192
Query: 340 TISDLRTEDSGTYICEVTNTFGSAEATGILMVID--------PLHVTLTPKKLKTGIGST 391
I D G Y C TN+ G+ + + + P ++ P + G +
Sbjct: 193 QIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGS 252
Query: 392 VILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRK 451
V ++C GSP ++W E + P++ + I L + ++S + Y C A
Sbjct: 253 VNITCVAVGSPMPYVKWMLGAEDLTPEDDMPI---GRNVLELNDVRQSAN--YTCVAMST 307
Query: 452 AQTAQDFAIIALE-----DGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDE 506
+ A I ++ GTP + S + + + G P P + + +
Sbjct: 308 LGVIEAIAQITVKALPKPPGTPVVTESTATSIT--------LTWDSGNPEPVSYYIIQHK 359
Query: 507 PIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPP 566
P + Y DG + +V G +R A N +G RGPP
Sbjct: 360 P-----KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIG----------RGPP 404
Query: 567 S 567
S
Sbjct: 405 S 405
Score = 60.1 bits (144), Expect = 2e-08
Identities = 88/341 (25%), Positives = 122/341 (35%), Gaps = 44/341 (12%)
Query: 374 PLHVTLTPKKLKTGI-GSTVILSCALTGSPEFTIRWYRNTELVLPD--EAISIRGLSNET 430
P T TP +TG+ G C TG P I W + + V E I S
Sbjct: 23 PPRFTRTPVD-QTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSV 81
Query: 431 LLITSAQKSHSGA-YQCFATRKAQ--TAQDFAIIALED----GTPRIVSSFSEKVVNPGE 483
L I + A Y+C A+ + + ED G P I KVV
Sbjct: 82 LRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTR 141
Query: 484 QFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSD---GTTI-SHMNVTGPQIRD 539
+++CAA G P P +TW D P+ ++ + S+ GT I + + + D
Sbjct: 142 TATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESD 201
Query: 540 GGVYRCTARNLVGSAEYQARINV---------RGPPSIR-AMRNITAVAGRDTLINCRVI 589
G Y C A N G+ Y A N+ R PP N + G I C +
Sbjct: 202 QGKYECVATNSAGT-RYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAV 260
Query: 590 GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSV 649
G P +KW A L + N L+L DV++ Y C V + I
Sbjct: 261 GSPMPYVKWMLGAEDLTPEDDMPIGRN-VLELNDVRQ---SANYTC-VAMSTLGVIEAIA 315
Query: 650 HVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITW 690
+ VK P PP + P V S I +TW
Sbjct: 316 QITVKALPK------PPGT-------PVVTESTATSITLTW 343
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 225 bits (574), Expect = 3e-58
Identities = 237/995 (23%), Positives = 398/995 (40%), Gaps = 93/995 (9%)
Query: 392 VILSCALTGSPEFTIRWYRNTELVLPDEAISIR-GLSNETLLITSAQKS-HSGAYQCFAT 449
+ L C G+P RW N + D ++ R L+ L++ + ++ +G YQCFAT
Sbjct: 46 ITLHCEARGNPSPHYRWQLNGSDI--DMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFAT 103
Query: 450 RKAQTAQD----FAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPP-----TVT 500
T LE+ ++ S+ S V G+ L+C PPP +
Sbjct: 104 NSLGTIVSREAKLQFAYLENFKTKMRSTVS---VREGQGVVLLCG----PPPHSGELSYA 156
Query: 501 WALDDEP--IVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSA---- 554
W ++ P + D +Q T H+ ++ + D G Y C ++V +A
Sbjct: 157 WIFNEYPSFVEEDSRRFVSQET-------GHLYISKVEPSDVGNYTCVVTSMVTNARVLG 209
Query: 555 --------------EYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYK 600
EY+ +I V+ P ++ A + G + C +G P I W +
Sbjct: 210 SPTPLVLRSDGVMGEYEPKIEVQFPETLPAAK------GSTVKLECFALGNPIPQINWRR 263
Query: 601 DALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQ 660
L + ++ +G L++ + Q+ D G Y C ++++ P +Q
Sbjct: 264 SDGLPFSSKIKLRKFSGVLEIPNFQQE-DAGSYECIAENSRGKNVARGRLTYYAKPHWVQ 322
Query: 661 PFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVS 720
+ ++ LY C S P W K+G ++ IE+ +L IS++S
Sbjct: 323 LIKDVEIAVEDSLYWECRASGKPKP-SYRWLKNGAALVLEERTQIEN----GALTISNLS 377
Query: 721 LKHNGNYTCIASNAAATVSRERQL-IVRVPPRFVVQPNNQ--DGIYGKAGVLNCSVDGYP 777
+ +G + CIA N V +L +V P F P + G L+C P
Sbjct: 378 VTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASP 437
Query: 778 PPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDI 837
WK KG + Q++ RI +L + L I +V + D G Y C A N G
Sbjct: 438 RALSSWK--KGDVSVQEHE------RISLLNDGGLKIANVTKADAGTYTCMAENQFGK-A 488
Query: 838 SKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGER--PIIIRWEKGDTVID--PDR 893
+ + L V P IT P+ G + L C + + II W + D D
Sbjct: 489 NGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDG 548
Query: 894 VMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPE- 952
+ +GD ++ ++LK + + + C L V+ P PPE
Sbjct: 549 SHFEKVGGSSSGDLMIRNIQLKHSGK-----YVCMVQTGVDSVSSAADLIVRGSPGPPEN 603
Query: 953 LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNK-SDSWDFKQSTRN-ISPTINQANIV 1010
+++ E+ + L W + D +S + + I+ + S W + I + A +V
Sbjct: 604 VKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHTATVV 663
Query: 1011 DLHPASVYSIRMYSFNKIGRSEPS-KELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKA 1069
+L+P Y R+ + NKIG EPS + TEEA P+ PP +V + + +TW
Sbjct: 664 ELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNGGGGSRSELVITWDP 723
Query: 1070 PKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAF 1129
+ELQNG GY + +R G V V+ +++ ++ Y V V +
Sbjct: 724 VPEELQNGEGFGYVVAFRPL--GVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVY 781
Query: 1130 NRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVI 1189
N G GP S + E+ P+ P V A S++S +SW+ P NG L GY V
Sbjct: 782 NNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVR 841
Query: 1190 FWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKED 1249
+W+ E + LRG++ Y V AY AG G S+ + + TK+
Sbjct: 842 YWNGGGKEESSSKMKVAGNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKKT 901
Query: 1250 VPGPPAGIKAVPSSASSVVVSW--LPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQ 1307
P P G ++ + V+++W + + + Y +F + + +
Sbjct: 902 PPSQPPGNVVWNATDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQNNVQVLNTNKTSAE 961
Query: 1308 LFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTI 1342
L I + Y++ V A T G G SSE++ I
Sbjct: 962 LVLPIK-----EDYIIEVKATTDGGDGTSSEQIRI 991
Score = 160 bits (405), Expect = 1e-38
Identities = 220/930 (23%), Positives = 366/930 (39%), Gaps = 121/930 (13%)
Query: 483 EQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIR-DGG 541
++ +L C A+G P P W L+ I HR Y ++ G + V P D G
Sbjct: 44 KKITLHCEARGNPSPHYRWQLNGSDIDMSMEHR---YKLNGGNLV----VINPNRNWDTG 96
Query: 542 VYRCTARNLVGS-AEYQARINVRGPPSIRA-MRNITAV-AGRDTLINCRVIGYPYY---- 594
Y+C A N +G+ +A++ + + MR+ +V G+ ++ C G P +
Sbjct: 97 TYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLC---GPPPHSGEL 153
Query: 595 SIKWYKD---ALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC---------SVLIQPQ 642
S W + + + D+ R V E G L ++ V+ D G Y C VL P
Sbjct: 154 SYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPS-DVGNYTCVVTSMVTNARVLGSPT 212
Query: 643 LSISQSVHVAVKVPPLIQPFEFP---PASIGQLLYIPCVVSSGDMPIRITWRKDGQVIIS 699
+ +S V + P I+ +FP PA+ G + + C +P +I WR+ + S
Sbjct: 213 PLVLRSDGVMGEYEPKIE-VQFPETLPAAKGSTVKLECFALGNPIP-QINWRRSDGLPFS 270
Query: 700 GSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFV-----V 754
I+ ++F L+I + + G+Y CIA N+ +L P +V V
Sbjct: 271 SK---IKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDV 327
Query: 755 QPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLI 814
+ +D +Y + C G P P W + + L R QI N +L I
Sbjct: 328 EIAVEDSLYWE-----CRASGKPKPSYRWLKNGAA--------LVLEERTQI-ENGALTI 373
Query: 815 RHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTI--AIKGHAKELNCTA 872
++ D G + C A N G S + V + +P + G L+C
Sbjct: 374 SNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKP 433
Query: 873 RGERPIIIRWEKGD-TVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAIN 931
R + W+KGD +V + +R+ D G LK+ + D+ ++C A N
Sbjct: 434 RASPRALSSWKKGDVSVQEHERIS----LLNDGG------LKIANVTKADAGTYTCMAEN 483
Query: 932 SYGEDRGLIQLTVQEPP----DPPELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNK 987
+G+ G L V EP P +++ G S+I +++
Sbjct: 484 QFGKANGTTHLVVTEPTRITLAPSNMDVSV---------------GESVILPCQVQHDPL 528
Query: 988 SD---SWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEA 1044
D +W F + + + V + IR G+ + + + +
Sbjct: 529 LDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSS 588
Query: 1045 APD-------GPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQY 1097
A D GPP +V + +T + Q++WK K + + Y I R +P S G
Sbjct: 589 AADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKD--NHSPVISYSIQAR--TPFSVGWQ 644
Query: 1098 SIVEMKATGDSEVY--TLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINATTLEDVPSQPP 1154
++ + D + + T+ L + +Y V A N+ G G PS T E VP PP
Sbjct: 645 TVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPP 704
Query: 1155 ENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTT----RE 1210
V + VI+W P NG GY V F L V W +Q + T+ R
Sbjct: 705 SEVNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVT-TW--IQTVVTSPDTPRY 761
Query: 1211 RVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPG-PPAGIKAVPSSASSVVV 1269
+ ++ Y V+V Y G+G S V + + E+ P P+ + A S+S + V
Sbjct: 762 VFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEV 821
Query: 1270 SW--LPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAA 1327
SW +P NG + Y + + G + + S+ + + + R+ L Y V A
Sbjct: 822 SWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGNETSARLRGLKSNLAYYTAVRA 881
Query: 1328 VTSAGRGNSSEKVTI----EPAGKAPAKII 1353
SAG G S V + P + P ++
Sbjct: 882 YNSAGAGPFSATVNVTTKKTPPSQPPGNVV 911
Score = 132 bits (331), Expect = 5e-30
Identities = 207/948 (21%), Positives = 348/948 (36%), Gaps = 105/948 (11%)
Query: 103 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYF 162
+ + C A G+PS RW L D + H ++ + + P N Y
Sbjct: 46 ITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLVVINP------NRNWDTGTYQ 99
Query: 163 CTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMR-GNVAVFKCLIPSSVQEYVSVVSW 221
C A N+ G I S +++ + E + ++ S+R G V C P E +
Sbjct: 100 CFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIF 159
Query: 222 EKDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD 280
+ + + R F++ G LYIS V+ D + Y C+ + + L +
Sbjct: 160 NEYPSFVEEDSRRFVSQETGHLYISKVEPSD-VGNYTCVVTSMVTNARVLGSPTPLVLRS 218
Query: 281 PA---ESIPTILDGF-HSQEVWAGHTVELPCTASGYPIPAIRWLK-DGRPLPADSRWTKR 335
E P I F + G TV+L C A G PIP I W + DG P + + K
Sbjct: 219 DGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKF 278
Query: 336 ITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILS 395
L I + + ED+G+Y C N+ G A G L H K ++ + ++
Sbjct: 279 SGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWE 338
Query: 396 CALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTA 455
C +G P+ + RW +N ++ +E I N L I++ + SG +QC A K
Sbjct: 339 CRASGKPKPSYRWLKNGAALVLEERTQI---ENGALTISNLSVTDSGMFQCIAENKHGLV 395
Query: 456 QDFAIIALEDGTPRIVSSFSEKV--VNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGS 513
A + + P + +K+ V G SL C + +P +W D V
Sbjct: 396 YSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGD---VSVQE 452
Query: 514 HRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIR-AMR 572
H G I+ NVT D G Y C A N G A + V P I A
Sbjct: 453 HERISLLNDGGLKIA--NVTK---ADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPS 507
Query: 573 NITAVAGRDTLINCRVIGYPYYSI--KWYKDALLLPDNHRQVVFE------NGTLKLTDV 624
N+ G ++ C+V P I WY + L FE +G L + ++
Sbjct: 508 NMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNI 567
Query: 625 QKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI--------------- 669
Q G+Y+C V S+S + + V+ P PP ++
Sbjct: 568 QL-KHSGKYVCMVQTGVD-SVSSAADLIVRGSP------GPPENVKVDEITDTTAQLSWK 619
Query: 670 -GQLLYIPCVVSS--GDMPIRITWRKDGQV--IISG---SGVTIESKEFMSSLQISSVSL 721
G+ + P + S P + W+ V +I G + +E ++ S
Sbjct: 620 EGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASN 679
Query: 722 KHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKV 781
K G + S R + + VPP + G G + V + P
Sbjct: 680 KIGGGEPSLPSEKV----RTEEAVPEVPP---------SEVNGGGGSRSELVITWDPVPE 726
Query: 782 MWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVL--EEDIGYYLCQASNGVGTDISK 839
++ +G G + P+ +T IQ + S R+V E + Y + GV + +
Sbjct: 727 ELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGE 786
Query: 840 SMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAI 899
F V + ++ T+A +++ + I + W + ++ Y +
Sbjct: 787 GPFSPV--TTVFSAEEEPTVA----PSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEV 840
Query: 900 ATKDNGDEVVSTLKLKPADRGDSV-----------FFSCHAINSYGED--RGLIQLTVQE 946
+ G + S+ K+K A S + + A NS G + +T ++
Sbjct: 841 RYWNGGGKEESSSKMKVAGNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKK 900
Query: 947 --PPDPPELEIREVKARSMNLRWTQ--RFDGNSIITGFDIEYKNKSDS 990
P PP + + L W Q + S +TG+ + Y+ S +
Sbjct: 901 TPPSQPPGNVVWNATDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQN 948
Score = 37.7 bits (86), Expect = 0.12
Identities = 19/66 (28%), Positives = 35/66 (53%), Gaps = 2/66 (3%)
Query: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
K + L C + G+P+P +W + D I +SM+ ++ +++ + D+G Y C
Sbjct: 44 KKITLHCEARGNPSPHYRWQLNGSD--IDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCF 101
Query: 1425 ATNTGG 1430
ATN+ G
Sbjct: 102 ATNSLG 107
Score = 37.7 bits (86), Expect = 0.12
Identities = 28/111 (25%), Positives = 46/111 (41%), Gaps = 4/111 (3%)
Query: 1353 ISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRA 1412
+ F T+ V+L C ++G+P P + W + +P S +L +G L +
Sbjct: 231 VQFPETLPAAKGSTVKLECFALGNPIPQINWRR---SDGLPFS-SKIKLRKFSGVLEIPN 286
Query: 1413 VKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTW 1463
+ ED+G Y C A N+ G + L P +L A +L W
Sbjct: 287 FQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYW 337
Score = 36.2 bits (82), Expect = 0.35
Identities = 46/221 (20%), Positives = 89/221 (40%), Gaps = 41/221 (18%)
Query: 1441 QVPPDQPRLTVSKTSASSITLTW--IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSER 1498
+VPP + + S S + +TW +P + G+V+ + W ++S +
Sbjct: 701 EVPPSE--VNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDT 758
Query: 1499 S---FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTH 1555
F+ +S+ + Y+VK+ N+ G G S + + EP+ + Q ++S+
Sbjct: 759 PRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSE 818
Query: 1556 ARLN-----------------LQGWNNGGCPITAIVLEYRPKGTWA-WQGLRANSSGEVF 1597
++ ++ WN GG ++ ++ T A +GL++N +
Sbjct: 819 IEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGNETSARLRGLKSNLA---- 874
Query: 1598 LTELREATWYELRMRACNSAGCGNETAQFATLDYDGSTIPP 1638
Y +RA NSAG G + AT++ PP
Sbjct: 875 ---------YYTAVRAYNSAGAGPFS---ATVNVTTKKTPP 903
Score = 33.1 bits (74), Expect = 3.0
Identities = 61/279 (21%), Positives = 97/279 (34%), Gaps = 46/279 (16%)
Query: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIH--TNGTLLLRAVKAEDSGYYTCT 1424
V L C P W K VS+ H I +G L + V D+G YTC
Sbjct: 427 VSLDCKPRASPRALSSWKKGD------VSVQEHERISLLNDGGLKIANVTKADAGTYTCM 480
Query: 1425 ATNTGGFDTIIVNLLVQVP------PDQPRLTVSKT----------SASSITLTWIPGDN 1468
A N G +L+V P P ++V ++ I TW
Sbjct: 481 AENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWY---- 536
Query: 1469 GGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLK-CGTWYKVKLAAKNSVGSGRIS 1527
G + + D S K SS + + LK G + + +SV S +
Sbjct: 537 ----FNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSA--A 590
Query: 1528 EIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQG 1587
++I + G + D+ I T A+L+ + + P+ + ++ R + WQ
Sbjct: 591 DLIVRGSPGPPENVKVDE-----ITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQT 645
Query: 1588 LRA------NSSGEVFLTELREATWYELRMRACNSAGCG 1620
+ + + EL YE R+ A N G G
Sbjct: 646 VTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGG 684
Score = 32.3 bits (72), Expect = 5.0
Identities = 17/60 (28%), Positives = 25/60 (41%), Gaps = 5/60 (8%)
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
C + G P P+ +W K+ + R NG L + + DSG + C A N G
Sbjct: 339 CRASGKPKPSYRWLKNGAALVLE-----ERTQIENGALTISNLSVTDSGMFQCIAENKHG 393
>gi|81158226 neuronal cell adhesion molecule isoform A precursor [Homo
sapiens]
Length = 1304
Score = 224 bits (571), Expect = 7e-58
Identities = 259/1064 (24%), Positives = 419/1064 (39%), Gaps = 128/1064 (12%)
Query: 370 MVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN-TELVLPDEAISIRGLSN 428
+V P +PK +++ C G P + W RN T + + +
Sbjct: 42 LVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGT 101
Query: 429 ETLLIT----SAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKV-VNPGE 483
TL+I +++ G YQC A + A I+ +P E + + G+
Sbjct: 102 GTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQ 161
Query: 484 QFSLMCAAK-GAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGV 542
L C G PPP + W +D+ S R +Q D + NV R+
Sbjct: 162 SLVLPCRPPIGLPPPIIFW-MDNSFQRLPQSERVSQGLNGD---LYFSNVLPEDTRED-- 215
Query: 543 YRCTAR-----------------------------NLVGSAEYQARINVRGPPSIRAMR- 572
Y C AR NL + Y A+ + PP+
Sbjct: 216 YICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEG 275
Query: 573 ---NITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFEN--GTLKLTDVQKG 627
N + G + C G P I W K+ +LP N + V++N TL++ V +
Sbjct: 276 NASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKN--RTVYKNFEKTLQIIHVSEA 333
Query: 628 MDEGEYLCSVLIQPQLSISQSVHVAVKVPPLI----QPFEFPPASIGQLLYIPCVVSSGD 683
D G Y C + +I ++ V VK P Q P G L+ C +
Sbjct: 334 -DSGNYQC-IAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLI---CRANGNP 388
Query: 684 MPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQ 743
P RI+W +G V I + K ++ S+V + + Y C ASN +
Sbjct: 389 KP-RISWLTNG-VPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAF 446
Query: 744 LIVRVPPRFVVQPNNQ--DGIYGKAGVLNCSVDGYPPPKVMW-KHAKGSGNPQQYHPVPL 800
+ V P ++ P N I + +L+C+ G P P + W K AKGS + + +
Sbjct: 447 VNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHE 506
Query: 801 TGRIQILPNSSLLIRHVLEED-IGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTI 859
G ++I V ++D G Y C A N +G + L +K P I P +
Sbjct: 507 NGTLEI---------PVAQKDSTGTYTCVARNKLGM-AKNEVHLEIKDPTWIVKQPEYAV 556
Query: 860 AIKGHAKELNCTARGERPI--IIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPA 917
+G C + + + + W K + + D R+ + KD+ L +
Sbjct: 557 VQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDE--RFTV-DKDH-------LVVADV 606
Query: 918 DRGDSVFFSCHAINSYGEDRGLIQLTVQEP----------PDPP-ELEIREVKARSMNLR 966
DS ++C A + L+V P P+PP +LE+ + +S+ L
Sbjct: 607 SDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLS 666
Query: 967 WTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFN 1026
WT D NS IT F IEY++ +S T A + L P YS R+ + N
Sbjct: 667 WTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQL-KLSPYVNYSFRVMAVN 725
Query: 1027 KIGRSEPSKELT-ISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIG 1085
IG+S PS+ T+ + PD P V ++ +TWK NG Y++
Sbjct: 726 SIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVS 785
Query: 1086 YRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATT 1145
+R+ G + S+V + Y + F Y + VQA N G P + + +
Sbjct: 786 WRQKD-GDDEWTSVV----VANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHS 840
Query: 1146 LEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWG----E 1201
ED+P P NVR + S +A + W P ++ G L+GYR+ +W + E
Sbjct: 841 GEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIE 900
Query: 1202 MQNITTTRERVE--LRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKA 1259
+ +T + L G+E F++Y++ V G+G S T E VP P+ +K
Sbjct: 901 KKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKI 960
Query: 1260 VPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSP--------EQLFYR 1311
V + S+ + W PP+ PNG++ +YT+ QP S +E P + +
Sbjct: 961 VNPTLDSLTLEWDPPSHPNGILTEYTL------KYQPINSTHELGPLVDLKIPANKTRWT 1014
Query: 1312 IAHLNRGQQYLLWVAAVTSAGRGNSSEK---VTIEPAGKAPAKI 1352
+ +LN +Y + A TSAG G+ + T++ AG P +
Sbjct: 1015 LKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEAGILPPDV 1058
Score = 166 bits (421), Expect = 2e-40
Identities = 264/1156 (22%), Positives = 434/1156 (37%), Gaps = 162/1156 (14%)
Query: 478 VVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH----RTNQYTMSDGTTISHMNVT 533
+++P E + C AKG PPP+ +W R+G+H + TM GT +N+
Sbjct: 57 IIDPRENIVIQCEAKGKPPPSFSWT-------RNGTHFDIDKDPLVTMKPGTGTLIINIM 109
Query: 534 --GPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI----RAMRNITAVAGRDTLINCR 587
G GVY+CTARN G+A I VR S + IT +G+ ++ CR
Sbjct: 110 SEGKAETYEGVYQCTARNERGAA-VSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCR 168
Query: 588 V-IGYPYYSIKWYKDALL-LPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSI 645
IG P I W ++ LP + R NG L ++V +Y+C +I
Sbjct: 169 PPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTI 228
Query: 646 SQSVHVAVKVPPL----------IQPFEF---------PPASI-------------GQLL 673
Q ++VKV + + EF PP + G +L
Sbjct: 229 QQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVL 288
Query: 674 YIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASN 733
+ C+ PI I W K+ ++ V K F +LQI VS +GNY CIA N
Sbjct: 289 SLECIAEGLPTPI-IYWAKEDGMLPKNRTVY---KNFEKTLQIIHVSEADSGNYQCIAKN 344
Query: 734 AAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQ 793
A + + V+ P ++ P N G+ G L C +G P P++ W +G P
Sbjct: 345 ALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLT---NGVPI 401
Query: 794 QYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITS 853
+ P + +I +++ +V E Y C ASN G ++ + + P I +
Sbjct: 402 EIAPDDPSRKID---GDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILT 458
Query: 854 HPNTTI-AIKGHAKELNCTARGERPIIIRWEKG--DTVIDPDRVMRYAIATKDNGDEVVS 910
NT I L+C G I W KG + + D + + +NG
Sbjct: 459 PANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLH-----ENG----- 508
Query: 911 TLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP---DPPELEIREVKARSMNLRW 967
TL++ A + + ++C A N G + + L +++P PE + + + ++
Sbjct: 509 TLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQ-RGSMVSFEC 567
Query: 968 TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIV--DLHPASVYSIRMYSF 1025
+ D +T ++ D ++ + T+++ ++V D+ + +
Sbjct: 568 KVKHDHTLSLTVLWLK--------DNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVAN 619
Query: 1026 NKIGRSEPSKELTISTEEAAP------DGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVI 1079
+ S L++ P PP D+ L +S+Q++W P + N I
Sbjct: 620 TTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSW-TPGDD-NNSPI 677
Query: 1080 RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSS 1138
+ I Y + + E+ T + L + Y V A N G PS
Sbjct: 678 TKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQL---KLSPYVNYSFRVMAVNSIGKSLPSE 734
Query: 1139 SEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGE 1198
+ T P + P V L D VI+W NG Y+V + D E
Sbjct: 735 ASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDE 794
Query: 1199 WGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPG-PPAGI 1257
W + + + + G F Y ++V A G +V+ + ED+P P +
Sbjct: 795 WTSV--VVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNV 852
Query: 1258 KAVPSSASSVVVSWLP-PTKP-NGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFY----- 1310
+ +++ V W P P K G ++ Y I+ S + F
Sbjct: 853 RVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTH 912
Query: 1311 -RIAHLNRGQQYLLWVAAVTSAGRGNSS-EKVTIEPAG--KAPAKIISFGGTV---TTPW 1363
+ L Y L V V G G +S ++V P G AP+ + T+ T W
Sbjct: 913 GMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEW 972
Query: 1364 ---------MKDVRL---PCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLR 1411
+ + L P NS + P V D IP + L + N + +
Sbjct: 973 DPPSHPNGILTEYTLKYQPINSTHELGPLV-------DLKIPANKTRWTLKNLNFSTRYK 1025
Query: 1412 AVKAEDSGYYTCTATNTGGFDTIIVNLLVQV------PPD---------QPRLTVSKTSA 1456
+Y T+ G I + V PPD PR++ + T+A
Sbjct: 1026 --------FYFYAQTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRIS-NLTAA 1076
Query: 1457 SSITLTWIPGDNGGSSIRGFVLQYSVDNS-EEWKDVFISSSERSFKLDSLKCGTWYKVKL 1515
++ T I + G F ++Y V S EEW+ ++ S F L L GT YKV++
Sbjct: 1077 AAETYANISWEYEGPEHVNFYVEYGVAGSKEEWRKEIVNGSRSFFGLKGLMPGTAYKVRV 1136
Query: 1516 AAKNSVGSGRISEIIE 1531
A G ++ E
Sbjct: 1137 GAVGDSGFVSSEDVFE 1152
Score = 123 bits (308), Expect = 2e-27
Identities = 148/590 (25%), Positives = 231/590 (39%), Gaps = 53/590 (8%)
Query: 103 VVVPCPAAGSPSAALRWYL-ATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDY 161
+V+ C A G P + W T DI P + GTL + S ++ + Y
Sbjct: 64 IVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETY--EGVY 121
Query: 162 FCTAENAAGKIRSPNIRVKAVFREPYTV-RVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 220
CTA N G S NI V+ +T ++E G V C P + ++
Sbjct: 122 QCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPP--PIIF 179
Query: 221 WEKDTVSIIPE-HRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSN------- 272
W ++ +P+ R +G LY S+V ED Y C + ++ +Q
Sbjct: 180 WMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVI 239
Query: 273 ---------GARLSVTD------PAESIPTILD---GFHSQEVWAGHTVELPCTASGYPI 314
A LS T+ E PT L ++E G+ + L C A G P
Sbjct: 240 SVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPT 299
Query: 315 PAIRWLKDGRPLPADSRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVID 373
P I W K+ LP + K L I + DSG Y C N G+ T + V
Sbjct: 300 PIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKA 359
Query: 374 PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN--TELVLPDEAISIRGLSNETL 431
+ P+ L G L C G+P+ I W N + PD+ R + +T+
Sbjct: 360 APYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDD--PSRKIDGDTI 417
Query: 432 LITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKV-VNPGEQFSLMCA 490
+ ++ Q+ S YQC A+ + A + + PRI++ + V L CA
Sbjct: 418 IFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCA 477
Query: 491 AKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNL 550
G+P PT+ W + + + Y + + T + + Q G Y C ARN
Sbjct: 478 FFGSPLPTIEWFKG----AKGSALHEDIYVLHENGT---LEIPVAQKDSTGTYTCVARNK 530
Query: 551 VGSAEYQARINVRGPPSIRAMRNITAVAGRDTLIN--CRVIGYPYYS--IKWYKDALLLP 606
+G A+ + + ++ P I + AV R ++++ C+V S + W KD LP
Sbjct: 531 LGMAKNEVHLEIKDPTWI-VKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELP 589
Query: 607 DNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVP 656
+ R V + L + DV D G Y C V S+S S ++V P
Sbjct: 590 SDERFTV-DKDHLVVADVSDD-DSGTYTC-VANTTLDSVSASAVLSVVAP 636
Score = 67.0 bits (162), Expect = 2e-10
Identities = 69/309 (22%), Positives = 115/309 (37%), Gaps = 22/309 (7%)
Query: 70 LDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYD 129
L ++H V + Y++ V G ++ C A G+P + W L G I
Sbjct: 346 LGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLI-CRANGNPKPRISW-LTNGVPIEI 403
Query: 130 VPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTV 189
P +G ++ ++ Y C A N G + + N V + P +
Sbjct: 404 APDDPSRKIDGDTIIFSNVQERSSAV-----YQCNASNEYGYLLA-NAFVNVLAEPPRIL 457
Query: 190 RVEDQ--RSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDV 247
+ + + A+ C S + + W K ++ + G V
Sbjct: 458 TPANTLYQVIANRPALLDCAFFGSP---LPTIEWFKGAKGSALHEDIYVLHENGTLEIPV 514
Query: 248 QKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPC 307
++D+ TY C+ ++K N L + DP I+ V G V C
Sbjct: 515 AQKDSTGTYTCVARNKLG---MAKNEVHLEIKDPT----WIVKQPEYAVVQRGSMVSFEC 567
Query: 308 TASGYPIPAIR--WLKDGRPLPADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEA 365
++ WLKD R LP+D R+T L ++D+ +DSGTY C T S A
Sbjct: 568 KVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSA 627
Query: 366 TGILMVIDP 374
+ +L V+ P
Sbjct: 628 SAVLSVVAP 636
Score = 66.6 bits (161), Expect = 2e-10
Identities = 86/371 (23%), Positives = 142/371 (38%), Gaps = 33/371 (8%)
Query: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHAN--GTLQLYPFSPSAFNSFIHDNDYFCT 164
C A G P+ + W G +P R V+ N TLQ+ S + +Y C
Sbjct: 292 CIAEGLPTPIIYWAKEDGM----LPKNRTVYKNFEKTLQIIHVSEA------DSGNYQCI 341
Query: 165 AENAAGKIRSP-NIRVKAVFREPYTVRVEDQRSMR-GNVAVFKCLIPSSVQEYVSVVSWE 222
A+NA G I ++RVKA PY + + G C + + +S ++
Sbjct: 342 AKNALGAIHHTISVRVKAA---PYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLT-N 397
Query: 223 KDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPA 282
+ I P+ + S+VQ+ + + Y+C ++Y +N + +P
Sbjct: 398 GVPIEIAPDDPSRKIDGDTIIFSNVQERSS-AVYQCNASNEYG--YLLANAFVNVLAEP- 453
Query: 283 ESIPTILDGFHS-QEVWAGHTVELPCTASGYPIPAIRWLKD--GRPLPADSRWTKRITGL 339
P IL ++ +V A L C G P+P I W K G L D L
Sbjct: 454 ---PRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTL 510
Query: 340 TISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALT 399
I + + +GTY C N G A+ L + DP + P+ GS V C +
Sbjct: 511 EIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVK 570
Query: 400 GSP--EFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQD 457
T+ W ++ + DE ++ + L++ SG Y C A +
Sbjct: 571 HDHTLSLTVLWLKDNRELPSDERFTV---DKDHLVVADVSDDDSGTYTCVANTTLDSVSA 627
Query: 458 FAIIALEDGTP 468
A++++ TP
Sbjct: 628 SAVLSVVAPTP 638
Score = 46.6 bits (109), Expect = 3e-04
Identities = 61/280 (21%), Positives = 106/280 (37%), Gaps = 32/280 (11%)
Query: 1381 VKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV 1440
V W KD+ + +P R L++ V +DSG YTC A T D++ + ++
Sbjct: 579 VLWLKDNRE--LP---SDERFTVDKDHLVVADVSDDDSGTYTCVANTT--LDSVSASAVL 631
Query: 1441 QVPPDQPR-------------LTVSKTSASSITLTWIPGDNGGSSIRGFVLQY--SVDNS 1485
V P L ++ S+ L+W PGD+ S I F+++Y ++
Sbjct: 632 SVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKP 691
Query: 1486 EEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEA-KTHGREPSFSKD 1544
W S ++ L Y ++ A NS+G SE E T EP K+
Sbjct: 692 GLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEP--DKN 749
Query: 1545 QHLFTHINSTHARL-----NLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLT 1599
+ S L L G+ + G + V + G W + + + ++
Sbjct: 750 PTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVS 809
Query: 1600 ELREATWYELRMRACNSAGCGNETAQFATLDYDGSTIPPI 1639
Y ++++A N G E A + + G +P +
Sbjct: 810 GTPTFVPYLIKVQALNDMGFAPEPA--VVMGHSGEDLPMV 847
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 222 bits (565), Expect = 3e-57
Identities = 221/807 (27%), Positives = 334/807 (41%), Gaps = 69/807 (8%)
Query: 161 YFCTAENAAGK-IRS--PNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVS 217
Y C N AG+ +R+ ++V F P T V + G+ V C + S V
Sbjct: 1910 YSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQ---VAGSPLVLTCDV-SGVP--AP 1963
Query: 218 VVSWEKDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSGETRQSNGARL 276
V+W KD + + + GG L +S +Q A TY C+ ++ + E R+ +
Sbjct: 1964 TVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQA-GTYTCVAENTQA-EARKDFVVAV 2021
Query: 277 SVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADS----RW 332
V S + V G V L C A G P P + WLKDG PL D R+
Sbjct: 2022 LVAPRIRSSGVARE----HHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRF 2077
Query: 333 TKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGI---G 389
L + LR D+G Y C N G + V+ P + T + G
Sbjct: 2078 YLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 2137
Query: 390 STVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFAT 449
V + C + GSP + W ++ L LP ++ S TL I+ Q + +G + C A
Sbjct: 2138 ELVTMVCPVRGSPPIHVSWLKDG-LPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 2196
Query: 450 RKAQTA-QDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 508
A A ++F + V ++ VV G L C A+G P P V+W D EP+
Sbjct: 2197 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPL 2256
Query: 509 VRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI 568
+ ++ G ++ + G D G Y C A + G A ++ V PP I
Sbjct: 2257 LSQ--------SLEQGPSLQ-LEAVGAG--DSGTYSCVAVSEAGEARRHFQLTVMEPPHI 2305
Query: 569 RAMRNITAVA---GRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQ 625
T ++ G + C G P +I W+KD L EN + + T V
Sbjct: 2306 EDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTR------LENNS-RATRVL 2358
Query: 626 KGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQL---LYIPCVVSSG 682
+ D G Y C + P +I +S V V+ PP I P +G L + C V +
Sbjct: 2359 RVRDAGLYTC-LAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 2417
Query: 683 DMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRER 742
P +ITW +DG I+ + E LQ+ ++S +G+Y+C A NAA + S
Sbjct: 2418 PAP-KITWHRDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAF 2474
Query: 743 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
++ + P P + + +L C DG P P V W+ + +P+ +
Sbjct: 2475 RVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPR-------SP 2527
Query: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIK 862
R +ILP SL I+ VL +D G+YLC ASN G+D ++ PA+ S N T+
Sbjct: 2528 RFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2587
Query: 863 GHAKELNCTARGE-RPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGD 921
A L C A G +P+++ W+ G + + Y + + L L D
Sbjct: 2588 TPAL-LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPS-------NALLLTAPGPQD 2639
Query: 922 SVFFSCHAINSYGEDRGLIQLTVQEPP 948
S F C N GE L Q+TV PP
Sbjct: 2640 SAQFECVVSNEVGEAHRLYQVTVHVPP 2666
Score = 216 bits (550), Expect = 2e-55
Identities = 234/905 (25%), Positives = 360/905 (39%), Gaps = 113/905 (12%)
Query: 90 DSLQQVTFSSSVGVVVPCPAAGSPSAALRWY-----LATGDDIYDVPHIRHVHANGTLQL 144
D L +T + + + C A G P A+RW+ ++ G+D Y + A G +
Sbjct: 1166 DPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTY-------LLAGGWMLK 1218
Query: 145 YPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRS----MRGN 200
+ + Y C A N AG+ R N V+ + P ++ ED + G
Sbjct: 1219 MTQTQEQDSGL-----YSCLASNEAGEARR-NFSVEVLV--PPSIENEDLEEVIKVLDGQ 1270
Query: 201 VAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCIT 260
A C + Q ++ W KD + I+ G L + Y CI
Sbjct: 1271 TAHLMCNVTGHPQPKLT---WFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIA 1327
Query: 261 KHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQE-----VWAGHTVELPCTASGYPIP 315
+ +T+ +LSV PTIL G V + + L C A +P P
Sbjct: 1328 ANAVGEKTKHF---QLSVL----LAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSP 1380
Query: 316 AIRWLKDGRPLPADS--RWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVID 373
I W+KDG P A + GL I + + ED+G Y C VTN G A + V+
Sbjct: 1381 NITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI 1440
Query: 374 PLHVT-------LTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGL 426
P ++ + K++KT + ST+ L C P TIRWY++ + V P + + G
Sbjct: 1441 PPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLG- 1499
Query: 427 SNETLLITSAQKSHSGAYQCFATRKA-----------------QTAQDFA----IIALED 465
L I Q S SG Y C AT A Q DF+ I++ E+
Sbjct: 1500 EGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREE 1559
Query: 466 GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGT 525
V+ + E V N L C PPP +TW +D+P+ ++ ++ G
Sbjct: 1560 EARGGVTEYREIVEN--NPAYLYCDTNAIPPPDLTWYREDQPLSAG-----DEVSVLQGG 1612
Query: 526 TISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI-----RAMRNITAVAGR 580
+ + + + + G Y C A N VG + V PP I + +T A
Sbjct: 1613 RVLQIPLV--RAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS 1670
Query: 581 DTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQ 640
+ C +G P +I W ++ L + R V E+G + + D Y+C V
Sbjct: 1671 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMC-VAEN 1729
Query: 641 PQLSISQSVHVAVKVPPLIQ--PFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVII 698
S + + V+VPP I E A + + +PC V + P +TW KD Q +
Sbjct: 1730 QAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNP-EVTWYKDSQALS 1788
Query: 699 SGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNN 758
G V + +LQ+ L +G YTC A NAA + QL V VPP F P
Sbjct: 1789 LGEEVFL--LPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRG 1846
Query: 759 -QDGIYGKAG---VLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLL- 813
QD + + G VL+C D P P V W + P+ L R Q L L
Sbjct: 1847 PQDAVLVRVGDKAVLSCETDALPEPTVTWY--------KDGQPLVLAQRTQALRGGQRLE 1898
Query: 814 IRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIA-IKGHAKELNCTA 872
I+ D G Y C+ SN G + ++ LTV++P + T++ + G L C
Sbjct: 1899 IQEAQVSDKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV 1957
Query: 873 RGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINS 932
G + W K ++ V + + ++ + +L+PA G ++C A N+
Sbjct: 1958 SGVPAPTVTWLKDRMPVESSAV--HGVVSRGGR---LQLSRLQPAQAGT---YTCVAENT 2009
Query: 933 YGEDR 937
E R
Sbjct: 2010 QAEAR 2014
Score = 211 bits (538), Expect = 5e-54
Identities = 336/1485 (22%), Positives = 545/1485 (36%), Gaps = 270/1485 (18%)
Query: 103 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGT--LQLYPFSPSAFNSFIHDND 160
V + C A G+PS L W L G+ + GT LQ++P + +D
Sbjct: 804 VRLTCNATGAPSPTLMW-LKDGNPVSPA---------GTPGLQVFPGGRVLTLASARASD 853
Query: 161 ---YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVS 217
Y C A +A G+ R V V P + E S+ N +V L S
Sbjct: 854 SGRYSCVAVSAVGEDRQDV--VLQVHMPPSILGEELNVSVVANESV--ALECQSHAMPPP 909
Query: 218 VVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
V+SW KD + P ++ L D Y C ++ +G + + +
Sbjct: 910 VLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQ-AGRSEKHYNLNVW 968
Query: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337
V A P L H+ V GH L C G P P I W KDG+PLP + + ++
Sbjct: 969 V---APVFP--LRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVS 1023
Query: 338 G----LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVT---LTPKKLKTGIGS 390
L + + GTY CE +N G++ L V P + P ++
Sbjct: 1024 AVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDG 1083
Query: 391 TVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATR 450
L C TG P T+ W R+ + V + + ++ ++L + AQ +H+G Y C A
Sbjct: 1084 VATLECNATGKPPPTVTWERDGQPVGAELGLQLQN-QGQSLHVERAQAAHTGRYSCVAEN 1142
Query: 451 KAQTAQ---DFAIIALED--GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDD 505
A A+ + +++ + G +++ + + +P +L+C A G PPP + W +
Sbjct: 1143 LAGRAERKFELSVLVPPELIGDLDPLTNITAALHSP---LTLLCEAMGIPPPAIRWFRGE 1199
Query: 506 EPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGP 565
EP+ S + Y ++ G + +T Q +D G+Y C A N G A + V P
Sbjct: 1200 EPV----SPGEDTYLLAGGWM---LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP 1252
Query: 566 PSIR---AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLT 622
PSI I + G+ + C V G+P + W+KD L + +G L L
Sbjct: 1253 PSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVL-LQ 1311
Query: 623 DVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLI------QPFEFPPASIGQLLYIP 676
+Q + + + ++ ++V + P I E ++ + +
Sbjct: 1312 VLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLI 1371
Query: 677 CVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAA 736
C + P ITW KDG + I+ LQI + + G YTC+ +N
Sbjct: 1372 CEALAFPSP-NITWMKDGAPFEASR--NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1428
Query: 737 TVSRERQLIVRVPPRFVVQPNNQDGIYGKAGV------------LNCSVDGYPPPKVMWK 784
+ + V +PP ++D G+ GV L C PPP + W
Sbjct: 1429 EAVKNYHVEVLIPPSI-----SKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWY 1483
Query: 785 HAKGSGNPQQYHPVPLTGRIQILPNSSLL-IRHVLEEDIGYYLCQASNGVGTDISKSMFL 843
+ PV + R+Q+L LL I+ D G YLC A+N G D + +
Sbjct: 1484 --------KDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGED-DQDFNV 1534
Query: 844 TVKIPAMITSHPNTTIAIKGHAKE--------------------LNCTARGERPIIIRWE 883
+++P M + + A + ++E L C P + W
Sbjct: 1535 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 1594
Query: 884 KGD---------TVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYG 934
+ D +V+ RV++ + +N +SC A N G
Sbjct: 1595 REDQPLSAGDEVSVLQGGRVLQIPLVRAENAGR-----------------YSCKASNEVG 1637
Query: 935 EDRGLIQLTVQEPP----DPPELEIREVKARSMN---------------LRWTQRFDGNS 975
ED +L V PP D EL + EV + + + W Q N
Sbjct: 1638 EDWLHYELLVLTPPVILGDTEEL-VEEVTVNASSTVSLQCPALGNPVPTISWLQ----NG 1692
Query: 976 IITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPAS---VYSIRMYSFNKIGRSE 1032
+ + D + ST ++ + + + S ++++R+ +I +
Sbjct: 1693 LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLD 1752
Query: 1033 PSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNG----VIRG---YQIG 1085
+ I + P DV P + +VTW + L G ++ G Q+G
Sbjct: 1753 LEQVTAILNSSVS---LPCDVHAHP----NPEVTWYKDSQALSLGEEVFLLPGTHTLQLG 1805
Query: 1086 YRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVV-QAFNRAGTGPSSSEINAT 1144
S +G Y+ + A G + K Q V+V AF +A GP +
Sbjct: 1806 RARLS--DSGMYTCEALNAAGRDQ--------KLVQLSVLVPPAFRQAPRGPQDA----- 1850
Query: 1145 TLEDVPSQPPENVRALSITSDVAVISWSEP--PRSTLNGVLKGYRVIFWSLYVDGEWGEM 1202
L D AV+S P T + W Y DG
Sbjct: 1851 --------------VLVRVGDKAVLSCETDALPEPT----------VTW--YKDG----- 1879
Query: 1203 QNITTTRERVELRGMEKFTNYSVQV--------LAYTQAGDGVRSSVLYIQ--------- 1245
Q + + LRG ++ QV AG+ VR+ L +Q
Sbjct: 1880 QPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPK 1939
Query: 1246 --TKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYET 1303
T V G P + S + V+WL P + + G+ S +
Sbjct: 1940 TETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMP---VESSAVHGVVSRGGRLQLSRLQP 1996
Query: 1304 SPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPW 1363
+ + +A + + +V AV A R I +G A + G
Sbjct: 1997 AQAGTYTCVAENTQAEARKDFVVAVLVAPR--------IRSSGVAREHHVLEG------- 2041
Query: 1364 MKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH-RLIHTNGTLLLRAVKAEDSGYYT 1422
++VRL C + G P P V W KD S + M H R G+L+L+ ++A D+G YT
Sbjct: 2042 -QEVRLDCEADGQPPPDVAWLKDG--SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYT 2098
Query: 1423 CTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGD 1467
C A N G D + + V VPP T+ + + S TL PG+
Sbjct: 2099 CVAHNPAGEDARLHTVNVLVPP-----TIKQGADGSGTLVSRPGE 2138
Score = 202 bits (515), Expect = 2e-51
Identities = 210/812 (25%), Positives = 340/812 (41%), Gaps = 63/812 (7%)
Query: 161 YFCTAENAAGKI-RSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQ-EYVSV 218
Y C AE+ AG I +S +RV+A P V R + G +A + ++ SV+ E
Sbjct: 2366 YTCLAESPAGAIEKSFRVRVQA---PPNIVGPRGPRFVVG-LAPGQLVLECSVEAEPAPK 2421
Query: 219 VSWEKDTVSIIPE-HRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
++W +D + + + H F L + + D+ Y C T +G T S R+
Sbjct: 2422 ITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADS-GDYSC-TARNAAGST--SVAFRVE 2477
Query: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPL-PADSRWTKRI 336
+ ++PTI G + V T LPC A G P P + W KD PL P R+
Sbjct: 2478 I----HTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILP 2533
Query: 337 TG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILS 395
G L I + +D+G Y+C +N+ GS L V++P + +P L + +L
Sbjct: 2534 EGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLP 2593
Query: 396 CALTGSPEFTIRWYRNTE-LVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQT 454
C +GSP+ + W+++ + L + + R L + LL+T+ S ++C + +
Sbjct: 2594 CEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGE 2653
Query: 455 AQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH 514
A + + P I ++ V L C + G P PTV+W+ + GS
Sbjct: 2654 AHRLYQVTVHV-PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSG 2712
Query: 515 RTNQYTMSDGTTISHMNVTGPQIR-DGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRN 573
Y +S + G + G Y C+ARN G A + V+ P ++ + +
Sbjct: 2713 ----YRVSPSGALE----IGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPS 2764
Query: 574 IT-AVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632
+ AVA + L+ C G P +I W K+ L + V G L++ D G
Sbjct: 2765 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPE-DAGN 2823
Query: 633 YLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI--GQLLYIPCVVSSGDMPIRITW 690
YLC + S + V+VPP+I+ P S G ++PC P ITW
Sbjct: 2824 YLC-IAKNSAGSAMGKTRLVVQVPPVIEN-GLPDLSTTEGSHAFLPCKARGSPEP-NITW 2880
Query: 691 RKDGQVIISGSG-VTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVP 749
KDGQ + G TI+ L + ++ + G YTC A NA R L + V
Sbjct: 2881 DKDGQPVSGAEGKFTIQPS---GELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL 2937
Query: 750 PRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPN 809
P F P ++ G L C+ G P P++ W + P+T +
Sbjct: 2938 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGW----------TVNDRPVTEGVSEQDG 2987
Query: 810 SSLLIR-HVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKEL 868
S L R V ED G Y+C A N VG + S + P + + + G + +L
Sbjct: 2988 GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQL 3047
Query: 869 NCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCH 928
+C RG+ I W K + +R+ + NG +L + +R D+ + C
Sbjct: 3048 DCVVRGDPVPDIHWIKDGLPLRGSH-LRHQL---QNG-----SLTIHRTERDDAGRYQCL 3098
Query: 929 AINSYGEDRGLIQLTVQEPP----DPPELEIR 956
A N G + ++ L +Q P +P ++ +R
Sbjct: 3099 AENEMGVAKKVVILVLQSAPVFQVEPQDMTVR 3130
Score = 201 bits (512), Expect = 5e-51
Identities = 217/884 (24%), Positives = 356/884 (40%), Gaps = 84/884 (9%)
Query: 103 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYF 162
+ + C + P +RWY G + ++ + LQ+ P S Y
Sbjct: 1466 LTLECESWAVPPPTIRWY-KDGQPVTPSSRLQVLGEGRLLQIQPTQVS------DSGRYL 1518
Query: 163 CTAENAAGK--------IRSPNIRVKAV-FREPYTVRVEDQRSMRGNVAVFKCLIPSS-V 212
C A N AG+ I+ P + K F + + ++ + RG V ++ ++ ++
Sbjct: 1519 CVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEA-RGGVTEYREIVENNPA 1577
Query: 213 QEYVSV-------VSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYS 265
Y ++W ++ + + G + + + + Y C ++
Sbjct: 1578 YLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 1637
Query: 266 GETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP 325
+ L V P + + V A TV L C A G P+P I WL++G P
Sbjct: 1638 EDWLHYE---LLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLP 1694
Query: 326 LPADSRWTKRITG--LTISDLRTEDSGTYICEVTNTFGSAEATGILMV-IDPLHVTLTPK 382
R G L +S D+ +Y+C N GSAE L V + P L +
Sbjct: 1695 FSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLE 1754
Query: 383 KLKTGIGSTVILSCALTGSPEFTIRWYRNTE-LVLPDEAISIRGLSNETLLITSAQKSHS 441
++ + S+V L C + P + WY++++ L L +E + G TL + A+ S S
Sbjct: 1755 QVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPG--THTLQLGRARLSDS 1812
Query: 442 GAYQCFATRKAQTAQDFAIIALEDGTPRIVSSF-----SEKVVNPGEQFSLMCAAKGAPP 496
G Y C A A +D ++ L P +V G++ L C P
Sbjct: 1813 GMYTCEALNAA--GRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 1870
Query: 497 PTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEY 556
PTVTW D +P+V + RT + G + + Q+ D G+Y C N+ G A
Sbjct: 1871 PTVTWYKDGQPLVL--AQRTQ--ALRGG---QRLEIQEAQVSDKGLYSCKVSNVAGEAVR 1923
Query: 557 QARINVRGPPSIR--AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNH-RQVV 613
+ V+ PP+ ++ VAG ++ C V G P ++ W KD + + + VV
Sbjct: 1924 TFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVV 1983
Query: 614 FENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFP---PASIG 670
G L+L+ +Q G Y C V Q + VAV V P I+ G
Sbjct: 1984 SRGGRLQLSRLQPA-QAGTYTC-VAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEG 2041
Query: 671 QLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCI 730
Q + + C + G P + W KDG + G + SL + + G YTC+
Sbjct: 2042 QEVRLDC-EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCV 2100
Query: 731 ASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAG---VLNCSVDGYPPPKVMWKHAK 787
A N A +R + V VPP + + + G + C V G PP V W
Sbjct: 2101 AHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWL--- 2157
Query: 788 GSGNPQQYHPVPLTGRIQILPNS-SLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVK 846
+ P+PL+ R + + +L I V D G + C A++ G ++ L V+
Sbjct: 2158 -----KDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGV-ADRNFTLQVQ 2211
Query: 847 IPAMI--TSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDN 904
+P ++ N + ++G EL C ARG ++ W K D + ++ ++
Sbjct: 2212 VPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMK-----DGEPLLSQSL----- 2261
Query: 905 GDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
E +L+L+ GDS +SC A++ GE R QLTV EPP
Sbjct: 2262 --EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP 2303
Score = 201 bits (510), Expect = 8e-51
Identities = 221/890 (24%), Positives = 348/890 (39%), Gaps = 95/890 (10%)
Query: 87 FVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYP 146
F N + V+ + +V+ C +G P+ + W L + V G LQL
Sbjct: 1935 FENPKTETVSQVAGSPLVLTCDVSGVPAPTVTW-LKDRMPVESSAVHGVVSRGGRLQLSR 1993
Query: 147 FSPSAFNSFIHDNDYFCTAENAAGKIR---------SPNIRVKAVFREPYTVRVEDQRSM 197
P+ + Y C AEN + R +P IR V RE + + ++ R
Sbjct: 1994 LQPAQAGT------YTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVR-- 2045
Query: 198 RGNVAVFKCLIPSSVQEYVSVVSWEKDTVSI---IPEHRFFITYHGGLYISDVQKEDALS 254
L + + V+W KD + + H F G L + ++ DA
Sbjct: 2046 ---------LDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA-G 2095
Query: 255 TYRCITKHKYSGETRQSNGARLSVTDPAESIPTI---LDGFHSQEVWAGHTVELPCTASG 311
Y C+ H +GE + + + V PTI DG + G V + C G
Sbjct: 2096 AYTCVA-HNPAGEDARLHTVNVLVP------PTIKQGADGSGTLVSRPGELVTMVCPVRG 2148
Query: 312 YPIPAIRWLKDGRPLPADSRWTKRITG--LTISDLRTEDSGTYICEVTNTFGSAEATGIL 369
P + WLKDG PLP R +G L IS ++ D+G + C + G A+ L
Sbjct: 2149 SPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTL 2208
Query: 370 MVIDPLHVTLTPKKLKTGI----GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRG 425
V P L P + + + GS V L C G P + W ++ E +L
Sbjct: 2209 QVQVP--PVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL----- 2261
Query: 426 LSNETLLITSAQKSHSGAYQCFATRKA-QTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQ 484
+L + + SG Y C A +A + + F + +E +E + PG
Sbjct: 2262 EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAP 2321
Query: 485 FSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYR 544
L+C A+G P P +TW +DG T S T + ++RD G+Y
Sbjct: 2322 MELLCDAQGTPQPNITWH-------KDGQALTRLENNSRATRVL-------RVRDAGLYT 2367
Query: 545 CTARNLVGSAEYQARINVRGPPSI---RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKD 601
C A + G+ E R+ V+ PP+I R R + +A ++ C V P I W++D
Sbjct: 2368 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRD 2427
Query: 602 ALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQP 661
++L ++ E G D G+Y C+ S S + V + P I+
Sbjct: 2428 GIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTAR-NAAGSTSVAFRVEIHTVPTIR- 2485
Query: 662 FEFPPA---SIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISS 718
PPA S+ Q +PC P+ ++WRKD +V + E SL+I
Sbjct: 2486 -SGPPAVNVSVNQTALLPCQADGVPAPL-VSWRKD-RVPLDPRSPRFEILP-EGSLRIQP 2541
Query: 719 VSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPP 778
V + G+Y C+ASN+A + + R L V PP P+N +L C G P
Sbjct: 2542 VLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPK 2601
Query: 779 PKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDIS 838
P V+W + Q+ G ++LP+++LL+ +D + C SN VG +
Sbjct: 2602 PLVVWWK-----DGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVG-EAH 2655
Query: 839 KSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYA 898
+ +TV +P I L C + G + W K + R Y
Sbjct: 2656 RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGA-RGSGYR 2714
Query: 899 IATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
++ L++ A + ++C A NS G + LTVQ P
Sbjct: 2715 VSPS-------GALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP 2757
Score = 192 bits (487), Expect = 4e-48
Identities = 185/690 (26%), Positives = 279/690 (40%), Gaps = 65/690 (9%)
Query: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG--LTISD 343
P I G ++ V +V L C ASG P P + W K +P+ + T + G L I
Sbjct: 695 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQ 754
Query: 344 LRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGST-VILSCALTGSP 402
+ D+G+Y C +N GS E L V P +TL P + +T V L+C TG+P
Sbjct: 755 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAP 814
Query: 403 EFTIRWYRNTELVLPDEAISIRGL-SNETLLITSAQKSHSGAYQCFA-TRKAQTAQDFAI 460
T+ W ++ V P ++ L + SA+ S SG Y C A + + QD +
Sbjct: 815 SPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQD--V 872
Query: 461 IALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI-VRDGSHRTNQY 519
+ P I+ V E +L C + PPP ++W D P+ R G H +
Sbjct: 873 VLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADK 932
Query: 520 TMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPP--SIRAMRNITAV 577
+ + V + D G Y C A N G +E +NV P +R +T
Sbjct: 933 AL--------LQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVR 984
Query: 578 AGRDTLINCRVIGYPYYSIKWYKDALLLPDNHR--QVVFENGTLKLTDVQKGMDEGEYLC 635
G T ++C G P+ I W KD LP Q V G L + EG Y C
Sbjct: 985 EGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTC 1044
Query: 636 SVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIG----QLLYIPCVVSSGDMPIRITWR 691
S SQ + + V VPP I PP + + + C ++G P +TW
Sbjct: 1045 ECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLEC-NATGKPPPTVTWE 1102
Query: 692 KDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPR 751
+DGQ + + G+ ++++ SL + H G Y+C+A N A R+ +L V VPP
Sbjct: 1103 RDGQPVGAELGLQLQNQG--QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPE 1160
Query: 752 FV--VQP-NNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILP 808
+ + P N L C G PPP + W + +P + + G +
Sbjct: 1161 LIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM---- 1216
Query: 809 NSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTI--AIKGHAK 866
L + E+D G Y C ASN G + ++ + V +P I + + + G
Sbjct: 1217 ---LKMTQTQEQDSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTA 1272
Query: 867 ELNCTARGERPIIIRWEK-------GDT-VIDPDRVMRYAIATKDNGDEVVSTLKLKPAD 918
L C G + W K GD I PD V+ L++ A+
Sbjct: 1273 HLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVL----------------LQVLQAN 1316
Query: 919 RGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
+ +SC A N+ GE QL+V P
Sbjct: 1317 LSSAGHYSCIAANAVGEKTKHFQLSVLLAP 1346
Score = 187 bits (476), Expect = 7e-47
Identities = 225/883 (25%), Positives = 343/883 (38%), Gaps = 119/883 (13%)
Query: 103 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYF 162
+V+ C P+ + W+ G + + H + LQL S + DY
Sbjct: 2408 LVLECSVEAEPAPKITWH-RDGIVLQEDAHTQFPERGRFLQLQALSTA------DSGDYS 2460
Query: 163 CTAENAAGKIRSPNIRVKAVFR-EPYTVRVEDQRSMRGNVAVFK-CLIPSSVQEY-VSVV 219
CTA NAAG FR E +TV NV+V + L+P +V
Sbjct: 2461 CTARNAAGS-------TSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLV 2513
Query: 220 SWEKDTVSIIPEH-RFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSV 278
SW KD V + P RF I G L I V +DA Y C+ + +G RQ G L V
Sbjct: 2514 SWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDA-GHYLCLASNS-AGSDRQ--GRDLRV 2569
Query: 279 TDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI-- 336
+P P I + + A LPC ASG P P + W KDG+ L D R +
Sbjct: 2570 LEP----PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKL--DFRLQQGAYR 2623
Query: 337 ----TGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTV 392
L ++ +DS + C V+N G A + V P + + + V
Sbjct: 2624 LLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPV 2683
Query: 393 ILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKA 452
+L+C TG P T+ W + L R + L I A H+G Y C A A
Sbjct: 2684 VLTCHSTGIPAPTVSWSK-AGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSA 2742
Query: 453 QTAQDFAIIALEDG-----TPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEP 507
A + ++ P +V + +E E+ L C A G P PT+TW +
Sbjct: 2743 GVAHKHVFLTVQASPVVKPLPSVVRAVAE------EEVLLPCEASGIPRPTITWQKEG-- 2794
Query: 508 IVRDGSHRTNQYTMSDGTTISHMNVTGPQIR-------DGGVYRCTARNLVGSAEYQARI 560
++ T +S + G Q+R D G Y C A+N GSA + R+
Sbjct: 2795 -------------LNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2841
Query: 561 NVRGPPSI-RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTL 619
V+ PP I + +++ G + C+ G P +I W KD + + +
Sbjct: 2842 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE 2901
Query: 620 KLTDVQKGMDEGEYLCSVLIQPQLSISQS---VHVAVKVPPLIQPFEFPPA-SIGQLLYI 675
L +G D G Y C+ + ++ ++ VH+ + V P+ + +G L++
Sbjct: 2902 LLVKNLEGQDAGTYTCTA----ENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWL 2957
Query: 676 PCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAA 735
C P RI W + + + G + ++ S+LQ ++VS + +G Y C A N
Sbjct: 2958 RCAARGSPTP-RIGWTVNDRPVTEG----VSEQDGGSTLQRAAVSREDSGTYVCWAENRV 3012
Query: 736 ATVSRERQLIVRVPP-------RFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKG 788
+ V+ P ++V+P G + L+C V G P P + W
Sbjct: 3013 GRTQAVSFVHVKEAPVLQGEAFSYLVEP------VGGSIQLDCVVRGDPVPDIHWIK--- 3063
Query: 789 SGNPQQYHPVPLTG---RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTV 845
+PL G R Q L N SL I +D G Y C A N +G K + L +
Sbjct: 3064 -------DGLPLRGSHLRHQ-LQNGSLTIHRTERDDAGRYQCLAENEMGV-AKKVVILVL 3114
Query: 846 KIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNG 905
+ + P G L C A GE I W + + R +R T +G
Sbjct: 3115 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLR----TLPDG 3170
Query: 906 DEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
+L L+ + GD+ + C A N G L V+ P
Sbjct: 3171 -----SLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3208
Score = 181 bits (460), Expect = 5e-45
Identities = 307/1422 (21%), Positives = 504/1422 (35%), Gaps = 195/1422 (13%)
Query: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAE 166
C G P + W + ++HV A G L + A + Y C
Sbjct: 993 CECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLA-----QEGTYTCECS 1047
Query: 167 NAAGKIRSPNIRVK-------AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVV 219
N G S +++++ A REP T ++ VA +C ++ + V
Sbjct: 1048 NVVGN-SSQDLQLEVHVPPQIAGPREPPT----QVSVVQDGVATLEC---NATGKPPPTV 1099
Query: 220 SWEKDTVSIIPEHRFFITYHG-GLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSV 278
+WE+D + E + G L++ Q Y C+ ++ R+ LSV
Sbjct: 1100 TWERDGQPVGAELGLQLQNQGQSLHVERAQAAHT-GRYSCVAENLAGRAERKFE---LSV 1155
Query: 279 TDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG 338
P E I LD + + L C A G P PAIRW + P+ + T + G
Sbjct: 1156 LVPPELIGD-LDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPV-SPGEDTYLLAG 1213
Query: 339 ---LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKK--LKTGIGSTVI 393
L ++ + +DSG Y C +N G A + V+ P + + +K G T
Sbjct: 1214 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAH 1273
Query: 394 LSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKA- 452
L C +TG P+ + W+++ + +A I L + A S +G Y C A
Sbjct: 1274 LMCNVTGHPQPKLTWFKDGRPLARGDAHHISP-DGVLLQVLQANLSSAGHYSCIAANAVG 1332
Query: 453 QTAQDFAIIALEDGTPRIV-----SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEP 507
+ + F + L P I+ S+ E V SL+C A P P +TW D P
Sbjct: 1333 EKTKHFQLSVLL--APTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP 1390
Query: 508 IVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS 567
+ + GT + + Q D G Y C N +G A + V PPS
Sbjct: 1391 F-----EASRNIQLLPGT--HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 1443
Query: 568 IR--------AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDAL-LLPDNHRQVVFENGT 618
I ++ + + C P +I+WYKD + P + QV+ E
Sbjct: 1444 ISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL 1503
Query: 619 LKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPF---------------- 662
L++ Q D G YLC V Q +V ++VPP+ Q
Sbjct: 1504 LQIQPTQVS-DSGRYLC-VATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEA 1561
Query: 663 -----EFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQIS 717
E+ Y+ C ++ P +TW ++ Q + +G V++ + LQI
Sbjct: 1562 RGGVTEYREIVENNPAYLYCDTNAIPPP-DLTWYREDQPLSAGDEVSVLQGGRV--LQIP 1618
Query: 718 SVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIY------GKAGVLNC 771
V ++ G Y+C ASN +L+V PP V+ + ++ + L C
Sbjct: 1619 LVRAENAGRYSCKASNEVGEDWLHYELLVLTPP--VILGDTEELVEEVTVNASSTVSLQC 1676
Query: 772 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLE-EDIGYYLCQAS 830
G P P + W N + P P R+Q+L + +L E D Y+C A
Sbjct: 1677 PALGNPVPTISWLQ-----NGLPFSPSP---RLQVLEDGQVLQVSTAEVADAASYMCVAE 1728
Query: 831 NGVGTDISKSMFLTVKIPAMITSHPNTTI-AIKGHAKELNCTARGERPIIIRWEKGDTVI 889
N G+ K L V++P I + AI + L C + W K +
Sbjct: 1729 NQAGS-AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQAL 1787
Query: 890 DPDRVMRYAIATKDNGDEV-----VSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTV 944
G+EV TL+L A DS ++C A+N+ G D+ L+QL+V
Sbjct: 1788 SL-------------GEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSV 1834
Query: 945 QEPP-------DPPELEIREVKARSMNLRWTQRFDGNSII---TGFDIEYKNKSDSWDFK 994
PP P + + V +++ T ++ G + ++ +
Sbjct: 1835 LVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGG 1894
Query: 995 QSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVT 1054
Q ++ + ++V + +F + P+ E + + G P+ +T
Sbjct: 1895 QRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLT 1954
Query: 1055 LQPVTSQSIQVTWKAPKKELQNGVI-----RGYQIGYRENSPGSNGQYSIVEMKATGDSE 1109
+ VTW + +++ + RG ++ P G Y+ V ++
Sbjct: 1955 CDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR 2014
Query: 1110 VYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLE---DVPSQPPENVRALSITSDV 1166
K F +V +G + + + QPP DV
Sbjct: 2015 -------KDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPP---------DV 2058
Query: 1167 AVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQ 1226
A + P + L+ Y+DG + L+G+ +
Sbjct: 2059 AWLKDGSPLGQDMGPHLR--------FYLDGG------------SLVLKGLRASDAGAYT 2098
Query: 1227 VLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTI 1286
+A+ AG+ R + + + G + S +V P V I
Sbjct: 2099 CVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCP------VRGSPPI 2152
Query: 1287 FCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAA----VTSAGRGNSSEKVTI 1342
S G P P T L + H R + L A V ++ G + T+
Sbjct: 2153 HVSWLKDGLPLPLSQRT----LLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTL 2208
Query: 1343 EPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLI 1402
+ + + F V V LPC + G P P V W KD E + +
Sbjct: 2209 QVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLL-------SQSL 2261
Query: 1403 HTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP 1444
+L L AV A DSG Y+C A + G L V PP
Sbjct: 2262 EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP 2303
Score = 172 bits (436), Expect = 3e-42
Identities = 205/883 (23%), Positives = 333/883 (37%), Gaps = 95/883 (10%)
Query: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAE 166
C A G P+ + W+ D + V+ G QL + ++ + Y C A
Sbjct: 333 CEARGVPTPNITWFK---DGALLPTSTKVVYTRGGRQLQLGRAQSSDAGV----YTCKAS 385
Query: 167 NAAGKIRSPNI-------RVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVV 219
NA G ++ PY V+ ++ G +C+ +
Sbjct: 386 NAVGAAEKATRLDVYVPPTIEGAGGRPYVVK-----AVAGRPVALECVARGHPSP---TL 437
Query: 220 SWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVT 279
SW + + + + + G + + E + Y C+ +GE + V
Sbjct: 438 SWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSP-AGEAVLQYSVEVQV- 495
Query: 280 DPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLP--ADSRWTKRIT 337
P + + + +G G +ELPC ASG P+P I+WL++GRP A + + T
Sbjct: 496 -PPQLL--VAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT 552
Query: 338 GLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIG-------- 389
L I + + SG + C+ TN G+A A V +H P L+ IG
Sbjct: 553 TLHIDHVELDHSGLFACQATNEAGTAGAE----VEVSVHGEWAPGVLEVPIGQYHWGXEH 608
Query: 390 -STVILSC--------ALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSH 440
S+ +C P W L I + L I
Sbjct: 609 HSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRD 668
Query: 441 SGAYQCFATRKA-QTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTV 499
G Y C AT A ++ ++ A+ L P I K V +L C A G PPP V
Sbjct: 669 EGIYTCAATNLAGESKREVALKVLV--PPNIEPGPVNKAVLENASVTLECLASGVPPPDV 726
Query: 500 TWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQAR 559
+W +P+ S DG + + Q+ D G YRC A N+ GS E +
Sbjct: 727 SWFKGHQPV----SSWMGVTVSVDGRV---LRIEQAQLSDAGSYRCVASNVAGSTELRYG 779
Query: 560 INVRGPPSIRAMRNI--TAVAGRDTLINCRVIGYPYYSIKWYKDA--LLLPDNHRQVVFE 615
+ V PP I ++ + + C G P ++ W KD + VF
Sbjct: 780 LRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFP 839
Query: 616 NGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI-GQLLY 674
G + + D G Y C V + Q V + V +PP I E + + + +
Sbjct: 840 GGRVLTLASARASDSGRYSC-VAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVA 898
Query: 675 IPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNA 734
+ C + P+ ++W KDG+ + GV + + + + LQ+ + G+YTC A N
Sbjct: 899 LECQSHAMPPPV-LSWWKDGRPLEPRPGVHLSADKAL--LQVDRADVWDAGHYTCEALNQ 955
Query: 735 AATVSRERQLIVRVPPRFVVQPNNQDGI-YGKAGVLNCSVDGYPPPKVMWKH----AKGS 789
A + L V V P F ++ ++ + G L+C G P PK+ W+ G
Sbjct: 956 AGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGE 1015
Query: 790 GNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPA 849
G Q+ V GR+ L + L G Y C+ SN VG S+ + L V +P
Sbjct: 1016 GAGLQH--VSAVGRLLYLGQAQL-------AQEGTYTCECSNVVGNS-SQDLQLEVHVPP 1065
Query: 850 MIT---SHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGD 906
I P ++ L C A G+ P + WE+ + + + ++ G
Sbjct: 1066 QIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAE----LGLQLQNQG- 1120
Query: 907 EVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPD 949
+L ++ A + +SC A N G +L+V PP+
Sbjct: 1121 ---QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPE 1160
Score = 164 bits (414), Expect = 1e-39
Identities = 164/632 (25%), Positives = 243/632 (38%), Gaps = 39/632 (6%)
Query: 339 LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCAL 398
L I + D G Y C TN G ++ L V+ P ++ P ++V L C
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 718
Query: 399 TGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDF 458
+G P + W++ + V +++ + L I AQ S +G+Y+C A+ A + +
Sbjct: 719 SGVPPPDVSWFKGHQPVSSWMGVTV-SVDGRVLRIEQAQLSDAGSYRCVASNVAGST-EL 776
Query: 459 AIIALEDGTPRIVSSFS-EKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTN 517
+ PRI S V L C A GAP PT+ W D P+ G+
Sbjct: 777 RYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQ 836
Query: 518 QYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMR-NITA 576
+ T++ + D G Y C A + VG + V PPSI N++
Sbjct: 837 VFPGGRVLTLASARAS-----DSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSV 891
Query: 577 VAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCS 636
VA + C+ P + W+KD L + + L D D G Y C
Sbjct: 892 VANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCE 951
Query: 637 VLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI--GQLLYIPCVVSSGDMPIRITWRKDG 694
L Q S + ++ V V P+ E ++ G + C P +I+WRKDG
Sbjct: 952 ALNQAGRS-EKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFP-KISWRKDG 1009
Query: 695 QVIISGSGVTIESKEFMSS-LQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFV 753
Q + G G ++ + L + L G YTC SN S++ QL V VPP+
Sbjct: 1010 QP-LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIA 1068
Query: 754 ---VQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQIL-PN 809
P + L C+ G PPP V W+ + PV +Q+
Sbjct: 1069 GPREPPTQVSVVQDGVATLECNATGKPPPTVTWE--------RDGQPVGAELGLQLQNQG 1120
Query: 810 SSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITS--HPNTTIAIKGHAK- 866
SL + G Y C A N G + L+V +P + P T I H+
Sbjct: 1121 QSLHVERAQAAHTGRYSCVAENLAGR-AERKFELSVLVPPELIGDLDPLTNITAALHSPL 1179
Query: 867 ELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFS 926
L C A G P IRW +G+ + P Y +A LK+ DS +S
Sbjct: 1180 TLLCEAMGIPPPAIRWFRGEEPVSPGE-DTYLLAGG-------WMLKMTQTQEQDSGLYS 1231
Query: 927 CHAINSYGEDRGLIQLTVQEPPDPPELEIREV 958
C A N GE R + V PP ++ EV
Sbjct: 1232 CLASNEAGEARRNFSVEVLVPPSIENEDLEEV 1263
Score = 160 bits (404), Expect = 2e-38
Identities = 182/717 (25%), Positives = 272/717 (37%), Gaps = 70/717 (9%)
Query: 286 PTILDGFHSQEVW--AGHTVELPCTASGYPIPAIRWLKDGRP-LPADSRWTKRITG--LT 340
P++L +QEV AG VEL C SG P P + W KD +P LP + G L
Sbjct: 216 PSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLR 275
Query: 341 ISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGI--GSTVILSCAL 398
I+ D G Y C + G L V P + + + + + V L C
Sbjct: 276 ITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEA 335
Query: 399 TGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDF 458
G P I W+++ L LP + L + AQ S +G Y C A+ A+
Sbjct: 336 RGVPTPNITWFKDGAL-LPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKA 394
Query: 459 AIIAL--------EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVR 510
+ + G P +V + + G +L C A+G P PT++W + P+
Sbjct: 395 TRLDVYVPPTIEGAGGRPYVVKAVA------GRPVALECVARGHPSPTLSWHHEGLPVAE 448
Query: 511 DGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI-- 568
R +DG+ + + P G+Y C A + G A Q + V+ PP +
Sbjct: 449 SNESRLE----TDGSVL---RLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLV 501
Query: 569 -RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKG 627
+ +T + G+ + C+ G P +I+W ++ + V GT D +
Sbjct: 502 AEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVEL 561
Query: 628 MDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLY-------IPCVV- 679
G + C + + ++ V V+V E P IGQ + P
Sbjct: 562 DHSGLFACQATNEAGTAGAE-VEVSVHGEWAPGVLEVP---IGQYHWGXEHHSSFPAACD 617
Query: 680 --------SSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIA 731
+ P+ W G + +G+ + + LQI V L+ G YTC A
Sbjct: 618 PPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPV-AYSLPPPLQIEKVDLRDEGIYTCAA 676
Query: 732 SNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGN 791
+N A RE L V VPP P N+ + + L C G PPP V W +
Sbjct: 677 TNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVS 736
Query: 792 PQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMI 851
V + GR+ L I D G Y C ASN G+ L V +P I
Sbjct: 737 SWMGVTVSVDGRV-------LRIEQAQLSDAGSYRCVASNVAGS-TELRYGLRVNVPPRI 788
Query: 852 TSHPNTTIAIKGHAK-ELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVS 910
T P+ + + L C A G + W K + P + G V
Sbjct: 789 TLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFP---GGRV-- 843
Query: 911 TLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPD--PPELEIREVKARSMNL 965
L L A DS +SC A+++ GEDR + L V PP EL + V S+ L
Sbjct: 844 -LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVAL 899
Score = 157 bits (398), Expect = 8e-38
Identities = 192/783 (24%), Positives = 300/783 (38%), Gaps = 114/783 (14%)
Query: 240 GGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEV-- 297
G L+++ V D+ Y C ++ +R+ A+L V P P+I + V
Sbjct: 57 GSLFLASVSPADS-GDYECQATNEVGSTSRR---AKLVVYVP----PSIREDGRKANVSG 108
Query: 298 WAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITGL---TISDLRTEDSGTYIC 354
AG ++ L C A+G+P+P I WLKD + + W L + R D G +
Sbjct: 109 MAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLH 168
Query: 355 EVTNTFG-----SAEATGILMVIDPLHVTLT----------------PKKLKTGI----- 388
G A+A G P L P L G
Sbjct: 169 FPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVL 228
Query: 389 ---GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 445
G+ V L C +G P + W ++ + VLP + L IT + G YQ
Sbjct: 229 GLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQ 288
Query: 446 CFATRKA-QTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALD 504
C A A Q A+DF + T + E V L+C A+G P P +TW
Sbjct: 289 CVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW--- 345
Query: 505 DEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG 564
+DG+ + + + Q D GVY C A N VG+AE R++V
Sbjct: 346 ----FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV 401
Query: 565 PPSIRAMRN----ITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLK 620
PP+I + AVAGR + C G+P ++ W+ + L + +++ + +G++
Sbjct: 402 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVL 461
Query: 621 LTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFE---FPPASIGQLLYIPC 677
+ G Y C V P V V+VPP + E +GQ L +PC
Sbjct: 462 RLESPGEASSGLYSC-VASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPC 520
Query: 678 VVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAAT 737
S +P I W ++G+ +GV + S+ ++L I V L H+G + C A+N A T
Sbjct: 521 QASGSPVP-TIQWLQNGRPAEELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAGT 577
Query: 738 VSRERQL---------IVRVP--------------PRFVVQPNNQD-GIYGKAGVLNCSV 773
E ++ ++ VP P P ++ G + K + V
Sbjct: 578 AGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPL----V 633
Query: 774 DGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGV 833
+G+ P +W + +G P Y P L I V D G Y C A+N
Sbjct: 634 EGWCSPGSLW--GEPTGIPVAYSLPP-----------PLQIEKVDLRDEGIYTCAATNLA 680
Query: 834 GTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDR 893
G + + + L V +P I P ++ + L C A G P + W KG +
Sbjct: 681 G-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWM 739
Query: 894 VMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPD---P 950
+ ++ + L+++ A D+ + C A N G L V PP P
Sbjct: 740 GVTVSVDGR--------VLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLP 791
Query: 951 PEL 953
P L
Sbjct: 792 PSL 794
Score = 155 bits (392), Expect = 4e-37
Identities = 187/764 (24%), Positives = 304/764 (39%), Gaps = 61/764 (7%)
Query: 95 VTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNS 154
V S + ++PC A G P+ + W P + G+L++ P
Sbjct: 2491 VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE-ILPEGSLRIQPVLAQ---- 2545
Query: 155 FIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNV-AVFKCLIPSSVQ 213
Y C A N+AG R R V P ++ + A+ C S +
Sbjct: 2546 --DAGHYLCLASNSAGSDRQG--RDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPK 2601
Query: 214 EYVSVVSWEKDTVSI---IPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQ 270
+V W KD + + + + + L ++ +D+ + + C+ ++ GE +
Sbjct: 2602 P---LVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDS-AQFECVVSNEV-GEAHR 2656
Query: 271 SNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPA-D 329
+ V PTI D V V L C ++G P P + W K G L A
Sbjct: 2657 LYQVTVHVP------PTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARG 2710
Query: 330 SRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGI 388
S + +G L I +G Y C N+ G A L V V P ++
Sbjct: 2711 SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVA 2770
Query: 389 GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA 448
V+L C +G P TI W + V +S + L L I A +G Y C A
Sbjct: 2771 EEEVLLPCEASGIPRPTITWQKEGLNVAT--GVSTQVLPGGQLRIAHASPEDAGNYLCIA 2828
Query: 449 TRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 508
A +A + ++ P I + + G L C A+G+P P +TW D +P+
Sbjct: 2829 KNSAGSAMGKTRLVVQV-PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPV 2887
Query: 509 VRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI 568
S ++T+ + N+ G +D G Y CTA N VG A + + + P
Sbjct: 2888 ----SGAEGKFTIQPSGELLVKNLEG---QDAGTYTCTAENAVGRARRRVHLTILVLPVF 2940
Query: 569 RAMRNITAVAGRDTL-INCRVIGYPYYSIKWYKDALLLPDNHRQVVFENG--TLKLTDVQ 625
+ ++ D L + C G P I W + + + V ++G TL+ V
Sbjct: 2941 TTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG---VSEQDGGSTLQRAAVS 2997
Query: 626 KGMDEGEYLCSVLIQPQLSISQSVH-VAVKVPPLIQ--PFEFPPASIGQLLYIPCVVSSG 682
+ D G Y+C + ++ +Q+V V VK P++Q F + +G + + CVV
Sbjct: 2998 RE-DSGTYVCWA--ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD 3054
Query: 683 DMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRER 742
+P I W KDG + + GS + + + SL I G Y C+A N +
Sbjct: 3055 PVP-DIHWIKDG-LPLRGSHLRHQLQN--GSLTIHRTERDDAGRYQCLAENEMGVAKKVV 3110
Query: 743 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
L+++ P F V+P + G L C G P P + W A P+ +
Sbjct: 3111 ILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAG--------QPLRASR 3162
Query: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVK 846
R++ LP+ SL + +V D G Y C A N +G+ +++ FL V+
Sbjct: 3163 RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARA-FLVVR 3205
Score = 145 bits (366), Expect = 4e-34
Identities = 164/675 (24%), Positives = 280/675 (41%), Gaps = 57/675 (8%)
Query: 91 SLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPS 150
S +T ++ ++PC A+GSP + W+ D + G +L P +
Sbjct: 2578 SPSNLTLTAHTPALLPCEASGSPKPLVVWWK-------DGQKLDFRLQQGAYRLLPSNAL 2630
Query: 151 AFNS-FIHDNDYF-CTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLI 208
+ D+ F C N G+ + P T+ +DQ + L
Sbjct: 2631 LLTAPGPQDSAQFECVVSNEVGEAHR---LYQVTVHVPPTI-ADDQTDFTVTMMAPVVLT 2686
Query: 209 PSSVQEYVSVVSWEKDTVSIIPEHRFF-ITYHGGLYISDVQKEDALSTYRCITKHKYSGE 267
S VSW K + + ++ G L I A Y C ++ +G
Sbjct: 2687 CHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHA-GRYTCSARNS-AGV 2744
Query: 268 TRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLP 327
+ + + + +P+++ +EV LPC ASG P P I W K+G +
Sbjct: 2745 AHKHVFLTVQASPVVKPLPSVVRAVAEEEVL------LPCEASGIPRPTITWQKEGLNV- 2797
Query: 328 ADSRWTKRITG--LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLK 385
A T+ + G L I+ ED+G Y+C N+ GSA L+V P + L
Sbjct: 2798 ATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLS 2857
Query: 386 TGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 445
T GS L C GSPE I W ++ + V E S E LL+ + + +G Y
Sbjct: 2858 TTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE-LLVKNLEGQDAGTYT 2916
Query: 446 CFATR---KAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
C A +A+ I+ L P + ++ + G++ L CAA+G+P P + W
Sbjct: 2917 CTAENAVGRARRRVHLTILVL----PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 2972
Query: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562
++D P+ S + G+T+ V+ D G Y C A N VG + + ++V
Sbjct: 2973 VNDRPVTEGVSEQ------DGGSTLQRAAVSR---EDSGTYVCWAENRVGRTQAVSFVHV 3023
Query: 563 RGPPSIR--AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLK 620
+ P ++ A + G ++C V G P I W KD L L +H + +NG+L
Sbjct: 3024 KEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLT 3083
Query: 621 LTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAV-KVPPL--IQPFEFPPASIGQLLYIPC 677
+ ++ D G Y C L + ++ +++ V + V + P+ ++P + S G + + C
Sbjct: 3084 IHRTERD-DAGRYQC--LAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRS-GDDVALRC 3139
Query: 678 VVSSGDMPIRITWRKDGQVIISGSGV-TIESKEFMSSLQISSVSLKHNGNYTCIASNAAA 736
++G+ I W + GQ + + + T+ SL + +V G Y C+A N
Sbjct: 3140 -QATGEPTPTIEWLQAGQPLRASRRLRTLPD----GSLWLENVETGDAGTYDCVAHNLLG 3194
Query: 737 TVSRERQLIVRVPPR 751
+ + L+VR P+
Sbjct: 3195 SATARAFLVVRGEPQ 3209
Score = 135 bits (341), Expect = 3e-31
Identities = 144/571 (25%), Positives = 218/571 (38%), Gaps = 59/571 (10%)
Query: 307 CTASGYPIPAIRWLKDGRPLPADSRWTKRIT---GLTISDLRTEDSGTYICEVTNTFGSA 363
C G P P + W K P + + L ++ + DSG Y C+ TN GS
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83
Query: 364 EATGILMVIDPLHVTLTPKKLKTG--IGSTVILSCALTGSPEFTIRWYRNTELV------ 415
L+V P + +K G ++ L C G P I W ++ +LV
Sbjct: 84 SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGW 143
Query: 416 ------LPDEAISIRGLSNE--TLLITSAQKSHSGAYQCFATRKAQTAQDF--AIIALED 465
L + L +E +L Q SG A AQT + + E
Sbjct: 144 AGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQ 203
Query: 466 -GTPRIVS-----------SFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGS 513
TP S + E + G L C G P P V W D +P++ G
Sbjct: 204 FPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGP 263
Query: 514 HRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRN 573
H Q DG + +TG + D G Y+C A + G ++ V PP+I
Sbjct: 264 HLQVQ---EDGQV---LRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNE 317
Query: 574 ITAVA-GRDTLIN--CRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDE 630
VA D L+ C G P +I W+KD LLP + + V G + D
Sbjct: 318 TGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDA 377
Query: 631 GEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPP----ASIGQLLYIPCVVSSGDMPI 686
G Y C + ++ + V VPP I+ P A G+ + + CV P
Sbjct: 378 GVYTCKA-SNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP- 435
Query: 687 RITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIV 746
++W +G + + +E+ S L++ S +G Y+C+AS+ A + + V
Sbjct: 436 TLSWHHEGLPVAESNESRLETDG--SVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV 493
Query: 747 RVPPRFVVQP--NNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRI 804
+VPP+ +V I G+ L C G P P + W +G P + L G
Sbjct: 494 QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQ---NGRPAE----ELAGVQ 546
Query: 805 QILPNSSLLIRHVLEEDIGYYLCQASNGVGT 835
++L I HV + G + CQA+N GT
Sbjct: 547 VASQGTTLHIDHVELDHSGLFACQATNEAGT 577
Score = 110 bits (276), Expect = 1e-23
Identities = 139/601 (23%), Positives = 231/601 (38%), Gaps = 68/601 (11%)
Query: 396 CALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTA 455
C G+P+ + W + + L +L + S + SG Y+C AT + +
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83
Query: 456 QDFAIIAL-------EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 508
A + + EDG VS + G+ +L C A G P P + W D + +
Sbjct: 84 SRRAKLVVYVPPSIREDGRKANVSGMA------GQSLTLECDANGFPVPEIVWLKDAQLV 137
Query: 509 VRDGSHRTNQYTMSDGTTISH------MNVTGPQIRDGGVYRCTARNLVGSAEYQA---- 558
+ + G H ++ P+I+ G R A+ GSA+ +A
Sbjct: 138 GVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQ-AGGSAQTKAPWXA 196
Query: 559 ------------RINVRGPPSIR---AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDAL 603
+ PPS+ A + + +AG D + C G P ++W KD
Sbjct: 197 GLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQ 256
Query: 604 -LLPDN-HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQP 661
+LP H QV + L++T G DEG Y C V P ++ + V PP I
Sbjct: 257 PVLPGGPHLQVQEDGQVLRITGSHVG-DEGRYQC-VAFSPAGQQARDFQLRVHAPPTIWG 314
Query: 662 F-EFPPASIGQLLYIPCVVSSGDMPI-RITWRKDGQVIISGSGVTIESKEFMSSLQISSV 719
E ++ + + + + +P ITW KDG ++ + + V LQ+
Sbjct: 315 SNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGG--RQLQLGRA 372
Query: 720 SLKHNGNYTCIASNAAATVSRERQLIVRVPPRFV---VQPNNQDGIYGKAGVLNCSVDGY 776
G YTC ASNA + +L V VPP +P + G+ L C G+
Sbjct: 373 QSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGH 432
Query: 777 PPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLL-IRHVLEEDIGYYLCQASNGVGT 835
P P + W H + PV + ++ + S+L + E G Y C AS+ G
Sbjct: 433 PSPTLSWHH--------EGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGE 484
Query: 836 DISK-SMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRV 894
+ + S+ + V ++ I G EL C A G I+W + + +
Sbjct: 485 AVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEEL 542
Query: 895 MRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELE 954
+A++ +TL + + S F+C A N G ++++V P LE
Sbjct: 543 AGVQVASQG------TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLE 596
Query: 955 I 955
+
Sbjct: 597 V 597
Score = 104 bits (260), Expect = 8e-22
Identities = 91/356 (25%), Positives = 145/356 (40%), Gaps = 26/356 (7%)
Query: 219 VSWEKDTVSIIPEHRFFITYHGG--LYISDVQKEDALSTYRCITKHKYSGETRQSNGARL 276
V W KD ++P G L I+ D Y+C+ +S +Q+ +L
Sbjct: 249 VEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDE-GRYQCVA---FSPAGQQARDFQL 304
Query: 277 SVTDPAESIPTILDGFHSQEV--WAGHTVELPCTASGYPIPAIRWLKDGRPLPADSR--W 332
V P PTI + EV H V+L C A G P P I W KDG LP ++ +
Sbjct: 305 RVHAP----PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVY 360
Query: 333 TKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLT---PKKLKTGIG 389
T+ L + ++ D+G Y C+ +N G+AE L V P + P +K G
Sbjct: 361 TRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAG 420
Query: 390 STVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFAT 449
V L C G P T+ W+ + L + + S L + S ++ SG Y C A+
Sbjct: 421 RPVALECVARGHPSPTLSWH-HEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVAS 479
Query: 450 RKA-QTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 508
A + +++ + + G+ L C A G+P PT+ W + P
Sbjct: 480 SPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP- 538
Query: 509 VRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG 564
S GTT +++ ++ G++ C A N G+A + ++V G
Sbjct: 539 ---AEELAGVQVASQGTT---LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 588
Score = 98.2 bits (243), Expect = 7e-20
Identities = 91/335 (27%), Positives = 136/335 (40%), Gaps = 20/335 (5%)
Query: 629 DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRI 688
DEG Y C+ S + V + V VPP I+P A + ++SG P +
Sbjct: 668 DEGIYTCAATNLAGES-KREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDV 726
Query: 689 TWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV 748
+W K Q + S GVT+ + L+I L G+Y C+ASN A + L V V
Sbjct: 727 SWFKGHQPVSSWMGVTVSVDGRV--LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV 784
Query: 749 PPRFVVQPNNQDGIYGKAGV-LNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQIL 807
PPR + P+ + V L C+ G P P +MW GNP P +Q+
Sbjct: 785 PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK---DGNPVSPAGTP---GLQVF 838
Query: 808 PNSSLL-IRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAK 866
P +L + D G Y C A + VG D + + L V +P I + +
Sbjct: 839 PGGRVLTLASARASDSGRYSCVAVSAVGED-RQDVVLQVHMPPSILGEELNVSVVANESV 897
Query: 867 ELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFS 926
L C + P ++ W K ++P R + A K + L++ AD D+ ++
Sbjct: 898 ALECQSHAMPPPVLSWWKDGRPLEP-RPGVHLSADK-------ALLQVDRADVWDAGHYT 949
Query: 927 CHAINSYGEDRGLIQLTVQEPPDPPELEIREVKAR 961
C A+N G L V P P E + R
Sbjct: 950 CEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVR 984
Score = 84.0 bits (206), Expect = 1e-15
Identities = 90/379 (23%), Positives = 146/379 (38%), Gaps = 28/379 (7%)
Query: 88 VNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPF 147
+ + L ++ + +PC A GSP + W G + + +G L +
Sbjct: 2849 IENGLPDLSTTEGSHAFLPCKARGSPEPNITWD-KDGQPVSGAEGKFTIQPSGELLVKNL 2907
Query: 148 SPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCL 207
+ Y CTAENA G+ R + + + +T D+ G+ +C
Sbjct: 2908 EGQDAGT------YTCTAENAVGRARR-RVHLTILVLPVFTTLPGDRSLRLGDRLWLRCA 2960
Query: 208 IPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG--LYISDVQKEDALSTYRCITKHKYS 265
S + W TV+ P GG L + V +ED+ TY C
Sbjct: 2961 ARGSP---TPRIGW---TVNDRPVTEGVSEQDGGSTLQRAAVSREDS-GTYVC------W 3007
Query: 266 GETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP 325
E R +S E+ + F G +++L C G P+P I W+KDG P
Sbjct: 3008 AENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 3067
Query: 326 LPADS-RWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKL 384
L R + LTI +D+G Y C N G A+ IL++ + P+ +
Sbjct: 3068 LRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDM 3127
Query: 385 KTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAY 444
G V L C TG P TI W + + + +R L + +L + + + +G Y
Sbjct: 3128 TVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASR--RLRTLPDGSLWLENVETGDAGTY 3185
Query: 445 QCFATR--KAQTAQDFAII 461
C A + TA+ F ++
Sbjct: 3186 DCVAHNLLGSATARAFLVV 3204
Score = 79.7 bits (195), Expect = 3e-14
Identities = 222/971 (22%), Positives = 338/971 (34%), Gaps = 190/971 (19%)
Query: 586 CRVIGYPYYSIKWYKDALLLPDNHRQ--VVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL 643
C G P + W K P + + V E G+L L V D G+Y C +
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPA-DSGDYECQATNEVG- 81
Query: 644 SISQSVHVAVKVPPLIQPFEFPPASI----GQLLYIPCVVSSGDMPIRITWRKDGQVI-- 697
S S+ + V VPP I+ + A++ GQ L + C + +P I W KD Q++
Sbjct: 82 STSRRAKLVVYVPPSIRE-DGRKANVSGMAGQSLTLECDANGFPVP-EIVWLKDAQLVGV 139
Query: 698 ---------------ISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVS--- 739
+ G + E + SL + +G A +A T +
Sbjct: 140 PLGWAGYGWDLGWGQVGGHRLLDEGQ----SLHFPRIQPGRSGRRGAQAGGSAQTKAPWX 195
Query: 740 ----------RERQLIVRVPPRFVVQPNNQD--GIYGKAGVLNCSVDGYPPPKVMWKHAK 787
PP + Q+ G+ G L C G P P+V W +
Sbjct: 196 AGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDR 255
Query: 788 GSGNPQQYH-PVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVK 846
P H V G++ + S HV +E G Y C A + G ++ L V
Sbjct: 256 QPVLPGGPHLQVQEDGQVLRITGS-----HVGDE--GRYQCVAFSPAGQQ-ARDFQLRVH 307
Query: 847 IPAMITSHPNT--TIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDN 904
P I T ++ H +L C ARG I W K ++ + Y +
Sbjct: 308 APPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQ- 366
Query: 905 GDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELE--------IR 956
L+L A D+ ++C A N+ G +L V P P +E ++
Sbjct: 367 -------LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVP---PTIEGAGGRPYVVK 416
Query: 957 EVKARSMNLRWTQRFDGNSIIT----GFDIEYKNKSDSWDFKQSTRNISPTINQANIVDL 1012
V R + L R + ++ G + N+S R SP + +
Sbjct: 417 AVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSC 476
Query: 1013 HPASV-------YSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQV 1065
+S YS+ + ++ +E ++T G P+++ Q S +
Sbjct: 477 VASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIV------GQPLELPCQASGSPVPTI 530
Query: 1066 TWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVV 1125
W LQNG G + S G+ VE LD+ FA
Sbjct: 531 QW------LQNGRPAEELAGVQVASQGTTLHIDHVE-----------LDHSGLFA----- 568
Query: 1126 VQAFNRAGTGPSSSEIN-----ATTLEDVPSQP----PENVRALSITSDVAVI-SWSEPP 1175
QA N AGT + E++ A + +VP E+ + D V W P
Sbjct: 569 CQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHP 628
Query: 1176 RSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTR--------ERVELRGMEKFTNYSVQV 1227
+ L ++G+ WGE I E+V+LR +T
Sbjct: 629 KPPL---VEGW------CSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYT-----C 674
Query: 1228 LAYTQAGDGVRSSVLYIQTKEDV-PGPPAGIKAVPSSASSVV-----------VSWLPPT 1275
A AG+ R L + ++ PGP KAV +AS + VSW
Sbjct: 675 AATNLAGESKREVALKVLVPPNIEPGPVN--KAVLENASVTLECLASGVPPPDVSWFKGH 732
Query: 1276 KPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRG- 1334
+P T+ G+ E + YR N VA T G
Sbjct: 733 QPVSSWMGVTVSVD----GRVLRIEQAQLSDAGSYRCVASN--------VAGSTELRYGL 780
Query: 1335 --NSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAI 1392
N ++T+ P+ P V TP VRL CN+ G P+P + W KD +
Sbjct: 781 RVNVPPRITLPPSLPGPV-------LVNTP----VRLTCNATGAPSPTLMWLKDGNPVS- 828
Query: 1393 PVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPD--QPRLT 1450
P G ++ L L + +A DSG Y+C A + G D V L V +PP L
Sbjct: 829 PAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELN 888
Query: 1451 VSKTSASSITL 1461
VS + S+ L
Sbjct: 889 VSVVANESVAL 899
Score = 53.9 bits (128), Expect = 2e-06
Identities = 41/135 (30%), Positives = 62/135 (45%), Gaps = 9/135 (6%)
Query: 1311 RIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLP 1370
RIAH + A SAG ++ ++ P I + ++T LP
Sbjct: 2812 RIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQ----VPPVIENGLPDLSTTEGSHAFLP 2867
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVS-MDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTG 1429
C + G P P + W KD + PVS +G I +G LL++ ++ +D+G YTCTA N
Sbjct: 2868 CKARGSPEPNITWDKDGQ----PVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 2923
Query: 1430 GFDTIIVNLLVQVPP 1444
G V+L + V P
Sbjct: 2924 GRARRRVHLTILVLP 2938
Score = 53.5 bits (127), Expect = 2e-06
Identities = 55/213 (25%), Positives = 86/213 (40%), Gaps = 17/213 (7%)
Query: 1252 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR 1311
GPPA +V +A L P + +GV + P +E PE
Sbjct: 2487 GPPAVNVSVNQTA-------LLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRI 2539
Query: 1312 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC 1371
L + + L +A+ ++ + +EP AP+ + T TP + LPC
Sbjct: 2540 QPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS-NLTLTAHTPAL----LPC 2594
Query: 1372 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1431
+ G P P V W KD + + +RL+ +N LLL A +DS + C +N G
Sbjct: 2595 EASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSN-ALLLTAPGPQDSAQFECVVSNEVGE 2653
Query: 1432 DTIIVNLLVQVPP----DQPRLTVSKTSASSIT 1460
+ + V VPP DQ TV+ + +T
Sbjct: 2654 AHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLT 2686
Score = 50.4 bits (119), Expect = 2e-05
Identities = 38/137 (27%), Positives = 60/137 (43%), Gaps = 21/137 (15%)
Query: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
++V LPC + G P P + W K+ + A VS + G L + ED+G Y C
Sbjct: 2772 EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQ----VLPGGQLRIAHASPEDAGNYLCI 2827
Query: 1425 ATNTGGFDTIIVNLLVQVPP----DQPRLTVSKTSASSI----------TLTWIPGDNGG 1470
A N+ G L+VQVPP P L+ ++ S + + +TW D G
Sbjct: 2828 AKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITW---DKDG 2884
Query: 1471 SSIRGFVLQYSVDNSEE 1487
+ G ++++ S E
Sbjct: 2885 QPVSGAEGKFTIQPSGE 2901
Score = 49.7 bits (117), Expect = 3e-05
Identities = 52/217 (23%), Positives = 89/217 (41%), Gaps = 21/217 (9%)
Query: 1325 VAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWT 1384
V A A R + TIE AG P + + G + V L C + G P+P + W
Sbjct: 388 VGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAG-------RPVALECVARGHPSPTLSWH 440
Query: 1385 KDSEDSAIPVSMDGHRLIHTNGTLL-LRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP 1443
+ +PV+ + T+G++L L + SG Y+C A++ G + ++ VQVP
Sbjct: 441 HEG----LPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVP 496
Query: 1444 PDQPRLTVSKTSASSITLTW----IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERS 1499
P+L V++ T+ +P GS + + +EE V ++S +
Sbjct: 497 ---PQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTT 553
Query: 1500 FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHG 1536
+D ++ A N G+ +E HG
Sbjct: 554 LHIDHVELDHSGLFACQATNEAGTAGAE--VEVSVHG 588
Score = 47.4 bits (111), Expect = 2e-04
Identities = 36/121 (29%), Positives = 48/121 (39%), Gaps = 26/121 (21%)
Query: 1367 VRLPCNSVGDPAPAVKWTKDSEDSA----IPVSMDGHRLIHTNGTLLLRAVKAEDSGYYT 1422
V L C + G P P V W K + + + VS+DG L + + D+G Y
Sbjct: 712 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGR-------VLRIEQAQLSDAGSYR 764
Query: 1423 CTATNTGGFDTIIVNLLVQVPP---------------DQPRLTVSKTSASSITLTWIPGD 1467
C A+N G + L V VPP RLT + T A S TL W+
Sbjct: 765 CVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDG 824
Query: 1468 N 1468
N
Sbjct: 825 N 825
Score = 47.4 bits (111), Expect = 2e-04
Identities = 35/126 (27%), Positives = 55/126 (43%), Gaps = 13/126 (10%)
Query: 1321 YLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPA 1380
Y+ W A GR + V ++ A + S+ + P ++L C GDP P
Sbjct: 3004 YVCW--AENRVGRTQAVSFVHVKEAPVLQGEAFSY---LVEPVGGSIQLDCVVRGDPVPD 3058
Query: 1381 VKWTKDSEDSAIPVSMDGHRLIHT--NGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNL 1438
+ W KD + + G L H NG+L + + +D+G Y C A N G +V L
Sbjct: 3059 IHWIKDG------LPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVIL 3112
Query: 1439 LVQVPP 1444
++Q P
Sbjct: 3113 VLQSAP 3118
Score = 43.9 bits (102), Expect = 0.002
Identities = 24/77 (31%), Positives = 36/77 (46%), Gaps = 5/77 (6%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLL-LRAVKAEDSGYYTCTATN 1427
L C+ +PAP + W +D I + D H G L L+A+ DSG Y+CTA N
Sbjct: 2410 LECSVEAEPAPKITWHRDG----IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARN 2465
Query: 1428 TGGFDTIIVNLLVQVPP 1444
G ++ + + P
Sbjct: 2466 AAGSTSVAFRVEIHTVP 2482
Score = 43.1 bits (100), Expect = 0.003
Identities = 29/85 (34%), Positives = 40/85 (47%), Gaps = 3/85 (3%)
Query: 1360 TTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSG 1419
T M V L C+S G PAP V W+K + + G+R + +G L + +G
Sbjct: 2676 TVTMMAPVVLTCHSTGIPAPTVSWSK--AGAQLGARGSGYR-VSPSGALEIGQALPIHAG 2732
Query: 1420 YYTCTATNTGGFDTIIVNLLVQVPP 1444
YTC+A N+ G V L VQ P
Sbjct: 2733 RYTCSARNSAGVAHKHVFLTVQASP 2757
Score = 41.2 bits (95), Expect = 0.011
Identities = 24/79 (30%), Positives = 37/79 (46%), Gaps = 4/79 (5%)
Query: 1366 DVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTA 1425
DV L C + G+P P ++W + + P+ +G+L L V+ D+G Y C A
Sbjct: 3134 DVALRCQATGEPTPTIEWLQAGQ----PLRASRRLRTLPDGSLWLENVETGDAGTYDCVA 3189
Query: 1426 TNTGGFDTIIVNLLVQVPP 1444
N G T L+V+ P
Sbjct: 3190 HNLLGSATARAFLVVRGEP 3208
Score = 37.7 bits (86), Expect = 0.12
Identities = 23/79 (29%), Positives = 35/79 (44%), Gaps = 10/79 (12%)
Query: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTAT 1426
+ L C++ G P P + W KD + RL N + R ++ D+G YTC A
Sbjct: 2322 MELLCDAQGTPQPNITWHKDGQALT--------RL--ENNSRATRVLRVRDAGLYTCLAE 2371
Query: 1427 NTGGFDTIIVNLLVQVPPD 1445
+ G + VQ PP+
Sbjct: 2372 SPAGAIEKSFRVRVQAPPN 2390
Score = 37.4 bits (85), Expect = 0.16
Identities = 48/196 (24%), Positives = 68/196 (34%), Gaps = 31/196 (15%)
Query: 1272 LPPTKPNGVIRKYTIFCSSPGSGQPAP-----------SEYETSPEQLFYRIAHLNRGQQ 1320
LPP+ P V+ + + +G P+P S T Q+F G+
Sbjct: 790 LPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVF------PGGRV 843
Query: 1321 YLLWVAAVTSAGR---------GNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC 1371
L A + +GR G + V ++ P I+ V+ + V L C
Sbjct: 844 LTLASARASDSGRYSCVAVSAVGEDRQDVVLQV--HMPPSILGEELNVSVVANESVALEC 901
Query: 1372 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1431
S P P + W KD G L L + D+G+YTC A N G
Sbjct: 902 QSHAMPPPVLSWWKDGRPLE---PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGR 958
Query: 1432 DTIIVNLLVQVPPDQP 1447
NL V V P P
Sbjct: 959 SEKHYNLNVWVAPVFP 974
Score = 37.0 bits (84), Expect = 0.20
Identities = 32/118 (27%), Positives = 46/118 (38%), Gaps = 5/118 (4%)
Query: 1408 LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKT--SASSITLTWIP 1465
L + V D G YTC ATN G V L V VPP+ V+K +S+TL +
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 718
Query: 1466 GDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGS 1523
+ F V + W V +S R +++ + + A N GS
Sbjct: 719 SGVPPPDVSWFKGHQPVSS---WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS 773
Score = 35.4 bits (80), Expect = 0.60
Identities = 24/63 (38%), Positives = 27/63 (42%), Gaps = 7/63 (11%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVS-MDGHRLIHTNGTLLLRAVKAEDSGYYTCTATN 1427
L C + G P P + WT + VS DG TL AV EDSG Y C A N
Sbjct: 2957 LRCAARGSPTPRIGWTVNDRPVTEGVSEQDG------GSTLQRAAVSREDSGTYVCWAEN 3010
Query: 1428 TGG 1430
G
Sbjct: 3011 RVG 3013
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 222 bits (565), Expect = 3e-57
Identities = 221/807 (27%), Positives = 334/807 (41%), Gaps = 69/807 (8%)
Query: 161 YFCTAENAAGK-IRS--PNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVS 217
Y C N AG+ +R+ ++V F P T V + G+ V C + S V
Sbjct: 3101 YSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQ---VAGSPLVLTCDV-SGVP--AP 3154
Query: 218 VVSWEKDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSGETRQSNGARL 276
V+W KD + + + GG L +S +Q A TY C+ ++ + E R+ +
Sbjct: 3155 TVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQA-GTYTCVAENTQA-EARKDFVVAV 3212
Query: 277 SVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADS----RW 332
V S + V G V L C A G P P + WLKDG PL D R+
Sbjct: 3213 LVAPRIRSSGVARE----HHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRF 3268
Query: 333 TKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGI---G 389
L + LR D+G Y C N G + V+ P + T + G
Sbjct: 3269 YLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 3328
Query: 390 STVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFAT 449
V + C + GSP + W ++ L LP ++ S TL I+ Q + +G + C A
Sbjct: 3329 ELVTMVCPVRGSPPIHVSWLKDG-LPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 3387
Query: 450 RKAQTA-QDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 508
A A ++F + V ++ VV G L C A+G P P V+W D EP+
Sbjct: 3388 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPL 3447
Query: 509 VRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI 568
+ ++ G ++ + G D G Y C A + G A ++ V PP I
Sbjct: 3448 LSQ--------SLEQGPSLQ-LEAVGAG--DSGTYSCVAVSEAGEARRHFQLTVMEPPHI 3496
Query: 569 RAMRNITAVA---GRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQ 625
T ++ G + C G P +I W+KD L EN + + T V
Sbjct: 3497 EDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTR------LENNS-RATRVL 3549
Query: 626 KGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQL---LYIPCVVSSG 682
+ D G Y C + P +I +S V V+ PP I P +G L + C V +
Sbjct: 3550 RVRDAGLYTC-LAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 3608
Query: 683 DMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRER 742
P +ITW +DG I+ + E LQ+ ++S +G+Y+C A NAA + S
Sbjct: 3609 PAP-KITWHRDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAF 3665
Query: 743 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
++ + P P + + +L C DG P P V W+ + +P+ +
Sbjct: 3666 RVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPR-------SP 3718
Query: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIK 862
R +ILP SL I+ VL +D G+YLC ASN G+D ++ PA+ S N T+
Sbjct: 3719 RFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 3778
Query: 863 GHAKELNCTARGE-RPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGD 921
A L C A G +P+++ W+ G + + Y + + L L D
Sbjct: 3779 TPAL-LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPS-------NALLLTAPGPQD 3830
Query: 922 SVFFSCHAINSYGEDRGLIQLTVQEPP 948
S F C N GE L Q+TV PP
Sbjct: 3831 SAQFECVVSNEVGEAHRLYQVTVHVPP 3857
Score = 216 bits (550), Expect = 2e-55
Identities = 235/862 (27%), Positives = 343/862 (39%), Gaps = 124/862 (14%)
Query: 158 DNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVS 217
+ Y CTA + AG R+ ++ P V + G AV C + + E
Sbjct: 491 EGTYECTAVSRAGTGRA-KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV---LGEAPY 546
Query: 218 VVSWEKDTVSIIPEHRFFITYHG--GLYISDVQKEDALSTYRCITKHKYSGETRQSNGA- 274
++W +D ++P + L IS + D Y+C+ + +NG
Sbjct: 547 NLTWVRDW-RVLPASTGRVAQLADLSLEISGIIPTDG-GRYQCVASN--------ANGVT 596
Query: 275 RLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTK 334
R SV P + SQ G V++ C+ASGYP P I W ++ + L DSR
Sbjct: 597 RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV 656
Query: 335 RITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVI 393
G L I + ED+G Y C+ TN G+ + T L DP V+ + +G +
Sbjct: 657 DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV 716
Query: 394 LSCALTGSPEFTIRWYR-NTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKA 452
L C +G P + WYR E++L E G S+ L I +AQ+ +G Y C A +
Sbjct: 717 LVCEASGVPPPRVIWYRGGLEMILAPE-----GSSSGKLRIPAAQERDAGTYTCRAVNEL 771
Query: 453 QTAQDFAIIALEDG-TPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWAL-DDEPI-V 509
A A I L G P++ + V G L C A G PPPTVTW D +P+ +
Sbjct: 772 GDAS--AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL 829
Query: 510 RDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG--PPS 567
R G+ R ++ D + +V D Y C ARN+ G + +AR+ V G PP
Sbjct: 830 RLGAGRGSRSRQPDSGVLFFESVAP---EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQ 886
Query: 568 IRAMR-NITAVAGRDTLINCRVI-GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQ 625
I + + + G+ + C V+ G P W KD LP R + +G+L L D
Sbjct: 887 IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHL-DRA 945
Query: 626 KGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPF-------EFPPASIGQLLYIPCV 678
G Y C V S + V + V+VPP I P E PAS +PCV
Sbjct: 946 LQEHAGRYSC-VATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPAS------LPCV 998
Query: 679 VSSGDMPIRITWRKDGQVIISGSGVTIESKE-------------------------FMS- 712
S P ITW K+ + S SKE F S
Sbjct: 999 ASGVPAP-TITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQ 1057
Query: 713 -------------------------SLQISSVSLKHNGNYTCIASNAAATVSRERQLIVR 747
SL+++ V + +G+Y C ASN A + S L V+
Sbjct: 1058 EMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1117
Query: 748 VPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQIL 807
VPP+ P + G+A LNC +G P P++ W V L GR
Sbjct: 1118 VPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSK----------DGVVLQGR---G 1164
Query: 808 PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTI-AIKGHAK 866
P S+ + D G Y C+ASN G D + ++ P + + + G
Sbjct: 1165 PQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENA 1224
Query: 867 ELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFS 926
L C ARG + W KG + + +A + G +++ + PAD GD +
Sbjct: 1225 SLPCPARGTPKPQVTWRKGPS--SEPLHGQPGVAVLEEGSLFLAS--VSPADSGD---YE 1277
Query: 927 CHAINSYGEDRGLIQLTVQEPP 948
C A N G +L V PP
Sbjct: 1278 CQATNEVGSTSRRAKLVVYVPP 1299
Score = 216 bits (550), Expect = 2e-55
Identities = 234/905 (25%), Positives = 360/905 (39%), Gaps = 113/905 (12%)
Query: 90 DSLQQVTFSSSVGVVVPCPAAGSPSAALRWY-----LATGDDIYDVPHIRHVHANGTLQL 144
D L +T + + + C A G P A+RW+ ++ G+D Y + A G +
Sbjct: 2357 DPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTY-------LLAGGWMLK 2409
Query: 145 YPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRS----MRGN 200
+ + Y C A N AG+ R N V+ + P ++ ED + G
Sbjct: 2410 MTQTQEQDSGL-----YSCLASNEAGEARR-NFSVEVLV--PPSIENEDLEEVIKVLDGQ 2461
Query: 201 VAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCIT 260
A C + Q ++ W KD + I+ G L + Y CI
Sbjct: 2462 TAHLMCNVTGHPQPKLT---WFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIA 2518
Query: 261 KHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQE-----VWAGHTVELPCTASGYPIP 315
+ +T+ +LSV PTIL G V + + L C A +P P
Sbjct: 2519 ANAVGEKTKHF---QLSVL----LAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSP 2571
Query: 316 AIRWLKDGRPLPADS--RWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVID 373
I W+KDG P A + GL I + + ED+G Y C VTN G A + V+
Sbjct: 2572 NITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI 2631
Query: 374 PLHVT-------LTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGL 426
P ++ + K++KT + ST+ L C P TIRWY++ + V P + + G
Sbjct: 2632 PPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLG- 2690
Query: 427 SNETLLITSAQKSHSGAYQCFATRKA-----------------QTAQDFA----IIALED 465
L I Q S SG Y C AT A Q DF+ I++ E+
Sbjct: 2691 EGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREE 2750
Query: 466 GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGT 525
V+ + E V N L C PPP +TW +D+P+ ++ ++ G
Sbjct: 2751 EARGGVTEYREIVEN--NPAYLYCDTNAIPPPDLTWYREDQPLSAG-----DEVSVLQGG 2803
Query: 526 TISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI-----RAMRNITAVAGR 580
+ + + + + G Y C A N VG + V PP I + +T A
Sbjct: 2804 RVLQIPLV--RAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS 2861
Query: 581 DTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQ 640
+ C +G P +I W ++ L + R V E+G + + D Y+C V
Sbjct: 2862 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMC-VAEN 2920
Query: 641 PQLSISQSVHVAVKVPPLIQ--PFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVII 698
S + + V+VPP I E A + + +PC V + P +TW KD Q +
Sbjct: 2921 QAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNP-EVTWYKDSQALS 2979
Query: 699 SGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNN 758
G V + +LQ+ L +G YTC A NAA + QL V VPP F P
Sbjct: 2980 LGEEVFL--LPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRG 3037
Query: 759 -QDGIYGKAG---VLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLL- 813
QD + + G VL+C D P P V W + P+ L R Q L L
Sbjct: 3038 PQDAVLVRVGDKAVLSCETDALPEPTVTWY--------KDGQPLVLAQRTQALRGGQRLE 3089
Query: 814 IRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIA-IKGHAKELNCTA 872
I+ D G Y C+ SN G + ++ LTV++P + T++ + G L C
Sbjct: 3090 IQEAQVSDKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV 3148
Query: 873 RGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINS 932
G + W K ++ V + + ++ + +L+PA G ++C A N+
Sbjct: 3149 SGVPAPTVTWLKDRMPVESSAV--HGVVSRGGR---LQLSRLQPAQAGT---YTCVAENT 3200
Query: 933 YGEDR 937
E R
Sbjct: 3201 QAEAR 3205
Score = 211 bits (538), Expect = 5e-54
Identities = 336/1485 (22%), Positives = 545/1485 (36%), Gaps = 270/1485 (18%)
Query: 103 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGT--LQLYPFSPSAFNSFIHDND 160
V + C A G+PS L W L G+ + GT LQ++P + +D
Sbjct: 1995 VRLTCNATGAPSPTLMW-LKDGNPVSPA---------GTPGLQVFPGGRVLTLASARASD 2044
Query: 161 ---YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVS 217
Y C A +A G+ R V V P + E S+ N +V L S
Sbjct: 2045 SGRYSCVAVSAVGEDRQDV--VLQVHMPPSILGEELNVSVVANESV--ALECQSHAMPPP 2100
Query: 218 VVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
V+SW KD + P ++ L D Y C ++ +G + + +
Sbjct: 2101 VLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQ-AGHSEKHYNLNVW 2159
Query: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337
V A P L H+ V GH L C G P P I W KDG+PLP + + ++
Sbjct: 2160 V---APVFP--LRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVS 2214
Query: 338 G----LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVT---LTPKKLKTGIGS 390
L + + GTY CE +N G++ L V P + P ++
Sbjct: 2215 AVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDG 2274
Query: 391 TVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATR 450
L C TG P T+ W R+ + V + + ++ ++L + AQ +H+G Y C A
Sbjct: 2275 VATLECNATGKPPPTVTWERDGQPVGAELGLQLQN-QGQSLHVERAQAAHTGRYSCVAEN 2333
Query: 451 KAQTAQ---DFAIIALED--GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDD 505
A A+ + +++ + G +++ + + +P +L+C A G PPP + W +
Sbjct: 2334 LAGRAERKFELSVLVPPELIGDLDPLTNITAALHSP---LTLLCEAMGIPPPAIRWFRGE 2390
Query: 506 EPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGP 565
EP+ S + Y ++ G + +T Q +D G+Y C A N G A + V P
Sbjct: 2391 EPV----SPGEDTYLLAGGWM---LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP 2443
Query: 566 PSIR---AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLT 622
PSI I + G+ + C V G+P + W+KD L + +G L L
Sbjct: 2444 PSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVL-LQ 2502
Query: 623 DVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLI------QPFEFPPASIGQLLYIP 676
+Q + + + ++ ++V + P I E ++ + +
Sbjct: 2503 VLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLI 2562
Query: 677 CVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAA 736
C + P ITW KDG + I+ LQI + + G YTC+ +N
Sbjct: 2563 CEALAFPSP-NITWMKDGAPFEASR--NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 2619
Query: 737 TVSRERQLIVRVPPRFVVQPNNQDGIYGKAGV------------LNCSVDGYPPPKVMWK 784
+ + V +PP ++D G+ GV L C PPP + W
Sbjct: 2620 EAVKNYHVEVLIPPSI-----SKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWY 2674
Query: 785 HAKGSGNPQQYHPVPLTGRIQILPNSSLL-IRHVLEEDIGYYLCQASNGVGTDISKSMFL 843
+ PV + R+Q+L LL I+ D G YLC A+N G D + +
Sbjct: 2675 --------KDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGED-DQDFNV 2725
Query: 844 TVKIPAMITSHPNTTIAIKGHAKE--------------------LNCTARGERPIIIRWE 883
+++P M + + A + ++E L C P + W
Sbjct: 2726 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 2785
Query: 884 KGD---------TVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYG 934
+ D +V+ RV++ + +N +SC A N G
Sbjct: 2786 REDQPLSAGDEVSVLQGGRVLQIPLVRAENAGR-----------------YSCKASNEVG 2828
Query: 935 EDRGLIQLTVQEPP----DPPELEIREVKARSMN---------------LRWTQRFDGNS 975
ED +L V PP D EL + EV + + + W Q N
Sbjct: 2829 EDWLHYELLVLTPPVILGDTEEL-VEEVTVNASSTVSLQCPALGNPVPTISWLQ----NG 2883
Query: 976 IITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPAS---VYSIRMYSFNKIGRSE 1032
+ + D + ST ++ + + + S ++++R+ +I +
Sbjct: 2884 LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLD 2943
Query: 1033 PSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNG----VIRG---YQIG 1085
+ I + P DV P + +VTW + L G ++ G Q+G
Sbjct: 2944 LEQVTAILNSSVS---LPCDVHAHP----NPEVTWYKDSQALSLGEEVFLLPGTHTLQLG 2996
Query: 1086 YRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVV-QAFNRAGTGPSSSEINAT 1144
S +G Y+ + A G + K Q V+V AF +A GP +
Sbjct: 2997 RARLS--DSGMYTCEALNAAGRDQ--------KLVQLSVLVPPAFRQAPRGPQDA----- 3041
Query: 1145 TLEDVPSQPPENVRALSITSDVAVISWSEP--PRSTLNGVLKGYRVIFWSLYVDGEWGEM 1202
L D AV+S P T + W Y DG
Sbjct: 3042 --------------VLVRVGDKAVLSCETDALPEPT----------VTW--YKDG----- 3070
Query: 1203 QNITTTRERVELRGMEKFTNYSVQV--------LAYTQAGDGVRSSVLYIQ--------- 1245
Q + + LRG ++ QV AG+ VR+ L +Q
Sbjct: 3071 QPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPK 3130
Query: 1246 --TKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYET 1303
T V G P + S + V+WL P + + G+ S +
Sbjct: 3131 TETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMP---VESSAVHGVVSRGGRLQLSRLQP 3187
Query: 1304 SPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPW 1363
+ + +A + + +V AV A R I +G A + G
Sbjct: 3188 AQAGTYTCVAENTQAEARKDFVVAVLVAPR--------IRSSGVAREHHVLEG------- 3232
Query: 1364 MKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH-RLIHTNGTLLLRAVKAEDSGYYT 1422
++VRL C + G P P V W KD S + M H R G+L+L+ ++A D+G YT
Sbjct: 3233 -QEVRLDCEADGQPPPDVAWLKDG--SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYT 3289
Query: 1423 CTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGD 1467
C A N G D + + V VPP T+ + + S TL PG+
Sbjct: 3290 CVAHNPAGEDARLHTVNVLVPP-----TIKQGADGSGTLVSRPGE 3329
Score = 202 bits (515), Expect = 2e-51
Identities = 210/812 (25%), Positives = 340/812 (41%), Gaps = 63/812 (7%)
Query: 161 YFCTAENAAGKI-RSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQ-EYVSV 218
Y C AE+ AG I +S +RV+A P V R + G +A + ++ SV+ E
Sbjct: 3557 YTCLAESPAGAIEKSFRVRVQA---PPNIVGPRGPRFVVG-LAPGQLVLECSVEAEPAPK 3612
Query: 219 VSWEKDTVSIIPE-HRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
++W +D + + + H F L + + D+ Y C T +G T S R+
Sbjct: 3613 ITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADS-GDYSC-TARNAAGST--SVAFRVE 3668
Query: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPL-PADSRWTKRI 336
+ ++PTI G + V T LPC A G P P + W KD PL P R+
Sbjct: 3669 I----HTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILP 3724
Query: 337 TG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILS 395
G L I + +D+G Y+C +N+ GS L V++P + +P L + +L
Sbjct: 3725 EGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLP 3784
Query: 396 CALTGSPEFTIRWYRNTE-LVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQT 454
C +GSP+ + W+++ + L + + R L + LL+T+ S ++C + +
Sbjct: 3785 CEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGE 3844
Query: 455 AQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH 514
A + + P I ++ V L C + G P PTV+W+ + GS
Sbjct: 3845 AHRLYQVTVHV-PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSG 3903
Query: 515 RTNQYTMSDGTTISHMNVTGPQIR-DGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRN 573
Y +S + G + G Y C+ARN G A + V+ P ++ + +
Sbjct: 3904 ----YRVSPSGALE----IGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPS 3955
Query: 574 IT-AVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632
+ AVA + L+ C G P +I W K+ L + V G L++ D G
Sbjct: 3956 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPE-DAGN 4014
Query: 633 YLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI--GQLLYIPCVVSSGDMPIRITW 690
YLC + S + V+VPP+I+ P S G ++PC P ITW
Sbjct: 4015 YLC-IAKNSAGSAMGKTRLVVQVPPVIEN-GLPDLSTTEGSHAFLPCKARGSPEP-NITW 4071
Query: 691 RKDGQVIISGSG-VTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVP 749
KDGQ + G TI+ L + ++ + G YTC A NA R L + V
Sbjct: 4072 DKDGQPVSGAEGKFTIQPS---GELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL 4128
Query: 750 PRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPN 809
P F P ++ G L C+ G P P++ W + P+T +
Sbjct: 4129 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGW----------TVNDRPVTEGVSEQDG 4178
Query: 810 SSLLIR-HVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKEL 868
S L R V ED G Y+C A N VG + S + P + + + G + +L
Sbjct: 4179 GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQL 4238
Query: 869 NCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCH 928
+C RG+ I W K + +R+ + NG +L + +R D+ + C
Sbjct: 4239 DCVVRGDPVPDIHWIKDGLPLRGSH-LRHQL---QNG-----SLTIHRTERDDAGRYQCL 4289
Query: 929 AINSYGEDRGLIQLTVQEPP----DPPELEIR 956
A N G + ++ L +Q P +P ++ +R
Sbjct: 4290 AENEMGVAKKVVILVLQSAPVFQVEPQDMTVR 4321
Score = 201 bits (512), Expect = 5e-51
Identities = 217/884 (24%), Positives = 356/884 (40%), Gaps = 84/884 (9%)
Query: 103 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYF 162
+ + C + P +RWY G + ++ + LQ+ P S Y
Sbjct: 2657 LTLECESWAVPPPTIRWY-KDGQPVTPSSRLQVLGEGRLLQIQPTQVS------DSGRYL 2709
Query: 163 CTAENAAGK--------IRSPNIRVKAV-FREPYTVRVEDQRSMRGNVAVFKCLIPSS-V 212
C A N AG+ I+ P + K F + + ++ + RG V ++ ++ ++
Sbjct: 2710 CVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEA-RGGVTEYREIVENNPA 2768
Query: 213 QEYVSV-------VSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYS 265
Y ++W ++ + + G + + + + Y C ++
Sbjct: 2769 YLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 2828
Query: 266 GETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP 325
+ L V P + + V A TV L C A G P+P I WL++G P
Sbjct: 2829 EDWLHYE---LLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLP 2885
Query: 326 LPADSRWTKRITG--LTISDLRTEDSGTYICEVTNTFGSAEATGILMV-IDPLHVTLTPK 382
R G L +S D+ +Y+C N GSAE L V + P L +
Sbjct: 2886 FSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLE 2945
Query: 383 KLKTGIGSTVILSCALTGSPEFTIRWYRNTE-LVLPDEAISIRGLSNETLLITSAQKSHS 441
++ + S+V L C + P + WY++++ L L +E + G TL + A+ S S
Sbjct: 2946 QVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPG--THTLQLGRARLSDS 3003
Query: 442 GAYQCFATRKAQTAQDFAIIALEDGTPRIVSSF-----SEKVVNPGEQFSLMCAAKGAPP 496
G Y C A A +D ++ L P +V G++ L C P
Sbjct: 3004 GMYTCEALNAA--GRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 3061
Query: 497 PTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEY 556
PTVTW D +P+V + RT + G + + Q+ D G+Y C N+ G A
Sbjct: 3062 PTVTWYKDGQPLVL--AQRTQ--ALRGG---QRLEIQEAQVSDKGLYSCKVSNVAGEAVR 3114
Query: 557 QARINVRGPPSIR--AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNH-RQVV 613
+ V+ PP+ ++ VAG ++ C V G P ++ W KD + + + VV
Sbjct: 3115 TFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVV 3174
Query: 614 FENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFP---PASIG 670
G L+L+ +Q G Y C V Q + VAV V P I+ G
Sbjct: 3175 SRGGRLQLSRLQPA-QAGTYTC-VAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEG 3232
Query: 671 QLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCI 730
Q + + C + G P + W KDG + G + SL + + G YTC+
Sbjct: 3233 QEVRLDC-EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCV 3291
Query: 731 ASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAG---VLNCSVDGYPPPKVMWKHAK 787
A N A +R + V VPP + + + G + C V G PP V W
Sbjct: 3292 AHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWL--- 3348
Query: 788 GSGNPQQYHPVPLTGRIQILPNS-SLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVK 846
+ P+PL+ R + + +L I V D G + C A++ G ++ L V+
Sbjct: 3349 -----KDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGV-ADRNFTLQVQ 3402
Query: 847 IPAMI--TSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDN 904
+P ++ N + ++G EL C ARG ++ W K D + ++ ++
Sbjct: 3403 VPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMK-----DGEPLLSQSL----- 3452
Query: 905 GDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
E +L+L+ GDS +SC A++ GE R QLTV EPP
Sbjct: 3453 --EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP 3494
Score = 201 bits (510), Expect = 8e-51
Identities = 221/890 (24%), Positives = 348/890 (39%), Gaps = 95/890 (10%)
Query: 87 FVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYP 146
F N + V+ + +V+ C +G P+ + W L + V G LQL
Sbjct: 3126 FENPKTETVSQVAGSPLVLTCDVSGVPAPTVTW-LKDRMPVESSAVHGVVSRGGRLQLSR 3184
Query: 147 FSPSAFNSFIHDNDYFCTAENAAGKIR---------SPNIRVKAVFREPYTVRVEDQRSM 197
P+ + Y C AEN + R +P IR V RE + + ++ R
Sbjct: 3185 LQPAQAGT------YTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVR-- 3236
Query: 198 RGNVAVFKCLIPSSVQEYVSVVSWEKDTVSI---IPEHRFFITYHGGLYISDVQKEDALS 254
L + + V+W KD + + H F G L + ++ DA
Sbjct: 3237 ---------LDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA-G 3286
Query: 255 TYRCITKHKYSGETRQSNGARLSVTDPAESIPTI---LDGFHSQEVWAGHTVELPCTASG 311
Y C+ H +GE + + + V PTI DG + G V + C G
Sbjct: 3287 AYTCVA-HNPAGEDARLHTVNVLVP------PTIKQGADGSGTLVSRPGELVTMVCPVRG 3339
Query: 312 YPIPAIRWLKDGRPLPADSRWTKRITG--LTISDLRTEDSGTYICEVTNTFGSAEATGIL 369
P + WLKDG PLP R +G L IS ++ D+G + C + G A+ L
Sbjct: 3340 SPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTL 3399
Query: 370 MVIDPLHVTLTPKKLKTGI----GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRG 425
V P L P + + + GS V L C G P + W ++ E +L
Sbjct: 3400 QVQVP--PVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL----- 3452
Query: 426 LSNETLLITSAQKSHSGAYQCFATRKA-QTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQ 484
+L + + SG Y C A +A + + F + +E +E + PG
Sbjct: 3453 EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAP 3512
Query: 485 FSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYR 544
L+C A+G P P +TW +DG T S T + ++RD G+Y
Sbjct: 3513 MELLCDAQGTPQPNITWH-------KDGQALTRLENNSRATRVL-------RVRDAGLYT 3558
Query: 545 CTARNLVGSAEYQARINVRGPPSI---RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKD 601
C A + G+ E R+ V+ PP+I R R + +A ++ C V P I W++D
Sbjct: 3559 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRD 3618
Query: 602 ALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQP 661
++L ++ E G D G+Y C+ S S + V + P I+
Sbjct: 3619 GIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTAR-NAAGSTSVAFRVEIHTVPTIR- 3676
Query: 662 FEFPPA---SIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISS 718
PPA S+ Q +PC P+ ++WRKD +V + E SL+I
Sbjct: 3677 -SGPPAVNVSVNQTALLPCQADGVPAPL-VSWRKD-RVPLDPRSPRFEILP-EGSLRIQP 3732
Query: 719 VSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPP 778
V + G+Y C+ASN+A + + R L V PP P+N +L C G P
Sbjct: 3733 VLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPK 3792
Query: 779 PKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDIS 838
P V+W + Q+ G ++LP+++LL+ +D + C SN VG +
Sbjct: 3793 PLVVWWK-----DGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVG-EAH 3846
Query: 839 KSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYA 898
+ +TV +P I L C + G + W K + R Y
Sbjct: 3847 RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGA-RGSGYR 3905
Query: 899 IATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
++ L++ A + ++C A NS G + LTVQ P
Sbjct: 3906 VSPS-------GALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP 3948
Score = 194 bits (494), Expect = 6e-49
Identities = 237/887 (26%), Positives = 353/887 (39%), Gaps = 133/887 (14%)
Query: 97 FSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFI 156
FS V V V C A+G P+ + W + HV A GTL + +P
Sbjct: 619 FSQGVEVKVSCSASGYPTPHISW--SRESQALQEDSRIHVDAQGTLIIQGVAPE------ 670
Query: 157 HDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSM--RGNVAVFKCLIPSSVQE 214
+Y C A N G + V + +P +V + + G AV C S V
Sbjct: 671 DAGNYSCQATNEVG---TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVPP 726
Query: 215 YVSVVSWEKDTVSII--PEHRFFITYHGGLYISDVQKEDALSTYRCITKHKY---SGETR 269
V W + + +I PE + G L I Q+ DA TY C ++ S E +
Sbjct: 727 --PRVIWYRGGLEMILAPEG----SSSGKLRIPAAQERDA-GTYTCRAVNELGDASAEIQ 779
Query: 270 QSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLK-DGRPL-- 326
+ G +T+ + L G + L C A+G P P + W + DG+PL
Sbjct: 780 LAVGHAPQLTELPRDVTVEL----------GRSALLACRATGRPPPTVTWRRGDGQPLGL 829
Query: 327 ----PADSRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVID--PLHVTL 379
SR + +G L + ED Y+CE N FG +A L+V P +
Sbjct: 830 RLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIAS 889
Query: 380 TPKKLKTGIGSTVILSC-ALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQK 438
+ ++ G V L C L G P W ++ + P SIR ++ +L + A +
Sbjct: 890 SAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIR--ADGSLHLDRALQ 947
Query: 439 SHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPT 498
H+G Y C AT A +Q + + PRI + + + N G SL C A G P PT
Sbjct: 948 EHAGRYSCVATNTA-GSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPT 1006
Query: 499 VTWALDDEPIVRDGSHRTNQYTMS-DGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQ 557
+TW + + G H Y +S +GT + + P +D G Y CTA N VG + +
Sbjct: 1007 ITWTKETNALTSRGPH----YNVSKEGTLL----IAQPSAQDAGAYVCTATNTVGFSSQE 1058
Query: 558 ARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENG 617
R++V N A++ W + LL +G
Sbjct: 1059 MRLSV----------NRLALS----------------KYVWEEYGLL----------PSG 1082
Query: 618 TLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPF-EFPPASIGQLLYIP 676
+L+L VQ G D G Y C+ P S S + V+VPP +QP +G+ L +
Sbjct: 1083 SLRLAQVQVG-DSGHYECTA-SNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLN 1140
Query: 677 CVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAA 736
CV P +++W KDG V++ G G S+ +++ G Y C ASN+A
Sbjct: 1141 CVAEGNPEP-QLSWSKDG-VVLQGRGP-------QGSVHFAAIRTSDAGRYRCEASNSAG 1191
Query: 737 TVSRERQLIVRVPPRFVVQPNN--QDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQ 794
+ E +L V PP + + + + G+ L C G P P+V W+ S
Sbjct: 1192 VDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSS----- 1246
Query: 795 YHPVPLTGR--IQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMI- 851
PL G+ + +L SL + V D G Y CQA+N VG+ S+ L V +P I
Sbjct: 1247 ---EPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS-TSRRAKLVVYVPPSIR 1302
Query: 852 -TSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVV- 909
+ G + L C A G I W K ++ + +A D G V
Sbjct: 1303 EDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVP--LGWAGYGWDLGWGQVG 1360
Query: 910 --------STLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
+L GDS +SC A N G + L V PP
Sbjct: 1361 GHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPP 1407
Score = 194 bits (492), Expect = 1e-48
Identities = 330/1361 (24%), Positives = 492/1361 (36%), Gaps = 254/1361 (18%)
Query: 240 GGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWA 299
G L+ V ED + Y C ++ + + ARL VT A P I + V
Sbjct: 845 GVLFFESVAPEDQ-APYVCEARNVFGKVQAE---ARLIVTGHAP--PQIASSAPTVRVLE 898
Query: 300 GHTVELPCTA-SGYPIPAIRWLKDGRPLPADSRWTKRITG-LTISDLRTEDSGTYICEVT 357
G V LPC +G P+P WLKDGRPLP SR + R G L + E +G Y C T
Sbjct: 899 GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVAT 958
Query: 358 NTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVL- 416
NT GS L+V P + T T G L C +G P TI W + T +
Sbjct: 959 NTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTS 1018
Query: 417 --PDEAISIRG------------------------------------------------- 425
P +S G
Sbjct: 1019 RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGL 1078
Query: 426 LSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQF 485
L + +L + Q SG Y+C A+ A +A ++ ++ P++ V GE
Sbjct: 1079 LPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQV-PPQVQPGPRVLKVLVGEAL 1137
Query: 486 SLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRC 545
L C A+G P P ++W+ D + G + ++ + D G YRC
Sbjct: 1138 DLNCVAEGNPEPQLSWSKDGVVLQGRGPQGS-------------VHFAAIRTSDAGRYRC 1184
Query: 546 TARNLVGSAEYQARINVRGPPSIRAMRN---ITAVAGRDTLINCRVIGYPYYSIKWYKDA 602
A N G ++ + V PP A + VAG + + C G P + W K
Sbjct: 1185 EASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGP 1244
Query: 603 LLLPDNHRQ--VVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQ 660
P + + V E G+L L V D G+Y C + S S+ + V VPP I+
Sbjct: 1245 SSEPLHGQPGVAVLEEGSLFLASVSPA-DSGDYECQATNEVG-STSRRAKLVVYVPPSIR 1302
Query: 661 PFEFPPASI----GQLLYIPCVVSSGDMPIRITWRKDGQVI-----------------IS 699
+ A++ GQ L + C + +P I W KD Q++ +
Sbjct: 1303 E-DGRKANVSGMAGQSLTLECDANGFPVP-EIVWLKDAQLVGVPLGWAGYGWDLGWGQVG 1360
Query: 700 GSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQ 759
G + E + SL + +G Y+C A N A T R+ L+V PP + Q
Sbjct: 1361 GHRLLDEGQ----SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQ 1416
Query: 760 D--GIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYH-PVPLTGRIQILPNSSLLIRH 816
+ G+ G L C G P P+V W + P H V G++ + S H
Sbjct: 1417 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGS-----H 1471
Query: 817 VLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNT--TIAIKGHAKELNCTARG 874
V +E G Y C A + G ++ L V P I T ++ H +L C ARG
Sbjct: 1472 VGDE--GRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARG 1528
Query: 875 ERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYG 934
I W K ++ + Y + L+L A D+ ++C A N+ G
Sbjct: 1529 VPTPNITWFKDGALLPTSTKVVYTRGGRQ--------LQLGRAQSSDAGVYTCKASNAVG 1580
Query: 935 EDRGLIQLTVQEPPDPPELE--------IREVKARSMNLRWTQRFDGNSIIT----GFDI 982
+L V P P +E ++ V R + L R + ++ G +
Sbjct: 1581 AAEKATRLDVYVP---PTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPV 1637
Query: 983 EYKNKSDSWDFKQSTRNISPTINQANIVDLHPASV-------YSIRMYSFNKIGRSEPSK 1035
N+S R SP + + +S YS+ + ++ +E
Sbjct: 1638 AESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLG 1697
Query: 1036 ELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNG 1095
++T G P+++ Q S + W LQNG G + S G+
Sbjct: 1698 QVTTIV------GQPLELPCQASGSPVPTIQW------LQNGRPAEELAGVQVASQGTTL 1745
Query: 1096 QYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEIN-----ATTLEDVP 1150
VE LD+ FA QA N AGT + E++ A + +VP
Sbjct: 1746 HIDHVE-----------LDHSGLFA-----CQATNEAGTAGAEVEVSVHGEWAPGVLEVP 1789
Query: 1151 SQP----PENVRALSITSDVAVI-SWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNI 1205
E+ + D V W P+ L ++G+ WGE I
Sbjct: 1790 IGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPL---VEGW------CSPGSLWGEPTGI 1840
Query: 1206 TTTR--------ERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDV-PGPPAG 1256
E+V+LR +T A AG+ R L + ++ PGP
Sbjct: 1841 PVAYSLPPPLQIEKVDLRDEGIYT-----CAATNLAGESKREVALKVLVPPNIEPGPVN- 1894
Query: 1257 IKAVPSSASSVV-----------VSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSP 1305
KAV +AS + VSW +P T+ G+ E
Sbjct: 1895 -KAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVD----GRVLRIEQAQLS 1949
Query: 1306 EQLFYRIAHLNRGQQYLLWVAAVTSAGRG---NSSEKVTIEPAGKAPAKIISFGGTVTTP 1362
+ YR N VA T G N ++T+ P+ P V TP
Sbjct: 1950 DAGSYRCVASN--------VAGSTELRYGLRVNVPPRITLPPSLPGPV-------LVNTP 1994
Query: 1363 WMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYT 1422
VRL CN+ G P+P + W KD + P G ++ L L + +A DSG Y+
Sbjct: 1995 ----VRLTCNATGAPSPTLMWLKDGNPVS-PAGTPGLQVFPGGRVLTLASARASDSGRYS 2049
Query: 1423 CTATNTGGFDTIIVNLLVQVPPD--QPRLTVSKTSASSITL 1461
C A + G D V L V +PP L VS + S+ L
Sbjct: 2050 CVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVAL 2090
Score = 192 bits (487), Expect = 4e-48
Identities = 185/690 (26%), Positives = 279/690 (40%), Gaps = 65/690 (9%)
Query: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG--LTISD 343
P I G ++ V +V L C ASG P P + W K +P+ + T + G L I
Sbjct: 1886 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQ 1945
Query: 344 LRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGST-VILSCALTGSP 402
+ D+G+Y C +N GS E L V P +TL P + +T V L+C TG+P
Sbjct: 1946 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAP 2005
Query: 403 EFTIRWYRNTELVLPDEAISIRGL-SNETLLITSAQKSHSGAYQCFA-TRKAQTAQDFAI 460
T+ W ++ V P ++ L + SA+ S SG Y C A + + QD +
Sbjct: 2006 SPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQD--V 2063
Query: 461 IALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI-VRDGSHRTNQY 519
+ P I+ V E +L C + PPP ++W D P+ R G H +
Sbjct: 2064 VLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADK 2123
Query: 520 TMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPP--SIRAMRNITAV 577
+ + V + D G Y C A N G +E +NV P +R +T
Sbjct: 2124 AL--------LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVR 2175
Query: 578 AGRDTLINCRVIGYPYYSIKWYKDALLLPDNHR--QVVFENGTLKLTDVQKGMDEGEYLC 635
G T ++C G P+ I W KD LP Q V G L + EG Y C
Sbjct: 2176 EGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTC 2235
Query: 636 SVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIG----QLLYIPCVVSSGDMPIRITWR 691
S SQ + + V VPP I PP + + + C ++G P +TW
Sbjct: 2236 ECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLEC-NATGKPPPTVTWE 2293
Query: 692 KDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPR 751
+DGQ + + G+ ++++ SL + H G Y+C+A N A R+ +L V VPP
Sbjct: 2294 RDGQPVGAELGLQLQNQG--QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPE 2351
Query: 752 FV--VQP-NNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILP 808
+ + P N L C G PPP + W + +P + + G +
Sbjct: 2352 LIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM---- 2407
Query: 809 NSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTI--AIKGHAK 866
L + E+D G Y C ASN G + ++ + V +P I + + + G
Sbjct: 2408 ---LKMTQTQEQDSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTA 2463
Query: 867 ELNCTARGERPIIIRWEK-------GDT-VIDPDRVMRYAIATKDNGDEVVSTLKLKPAD 918
L C G + W K GD I PD V+ L++ A+
Sbjct: 2464 HLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVL----------------LQVLQAN 2507
Query: 919 RGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
+ +SC A N+ GE QL+V P
Sbjct: 2508 LSSAGHYSCIAANAVGEKTKHFQLSVLLAP 2537
Score = 187 bits (476), Expect = 7e-47
Identities = 225/883 (25%), Positives = 343/883 (38%), Gaps = 119/883 (13%)
Query: 103 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYF 162
+V+ C P+ + W+ G + + H + LQL S + DY
Sbjct: 3599 LVLECSVEAEPAPKITWH-RDGIVLQEDAHTQFPERGRFLQLQALSTA------DSGDYS 3651
Query: 163 CTAENAAGKIRSPNIRVKAVFR-EPYTVRVEDQRSMRGNVAVFK-CLIPSSVQEY-VSVV 219
CTA NAAG FR E +TV NV+V + L+P +V
Sbjct: 3652 CTARNAAGS-------TSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLV 3704
Query: 220 SWEKDTVSIIPEH-RFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSV 278
SW KD V + P RF I G L I V +DA Y C+ + +G RQ G L V
Sbjct: 3705 SWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDA-GHYLCLASNS-AGSDRQ--GRDLRV 3760
Query: 279 TDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI-- 336
+P P I + + A LPC ASG P P + W KDG+ L D R +
Sbjct: 3761 LEP----PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKL--DFRLQQGAYR 3814
Query: 337 ----TGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTV 392
L ++ +DS + C V+N G A + V P + + + V
Sbjct: 3815 LLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPV 3874
Query: 393 ILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKA 452
+L+C TG P T+ W + L R + L I A H+G Y C A A
Sbjct: 3875 VLTCHSTGIPAPTVSWSK-AGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSA 3933
Query: 453 QTAQDFAIIALEDG-----TPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEP 507
A + ++ P +V + +E E+ L C A G P PT+TW +
Sbjct: 3934 GVAHKHVFLTVQASPVVKPLPSVVRAVAE------EEVLLPCEASGIPRPTITWQKEG-- 3985
Query: 508 IVRDGSHRTNQYTMSDGTTISHMNVTGPQIR-------DGGVYRCTARNLVGSAEYQARI 560
++ T +S + G Q+R D G Y C A+N GSA + R+
Sbjct: 3986 -------------LNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 4032
Query: 561 NVRGPPSI-RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTL 619
V+ PP I + +++ G + C+ G P +I W KD + + +
Sbjct: 4033 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE 4092
Query: 620 KLTDVQKGMDEGEYLCSVLIQPQLSISQS---VHVAVKVPPLIQPFEFPPA-SIGQLLYI 675
L +G D G Y C+ + ++ ++ VH+ + V P+ + +G L++
Sbjct: 4093 LLVKNLEGQDAGTYTCTA----ENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWL 4148
Query: 676 PCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAA 735
C P RI W + + + G + ++ S+LQ ++VS + +G Y C A N
Sbjct: 4149 RCAARGSPTP-RIGWTVNDRPVTEG----VSEQDGGSTLQRAAVSREDSGTYVCWAENRV 4203
Query: 736 ATVSRERQLIVRVPP-------RFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKG 788
+ V+ P ++V+P G + L+C V G P P + W
Sbjct: 4204 GRTQAVSFVHVKEAPVLQGEAFSYLVEP------VGGSIQLDCVVRGDPVPDIHWIK--- 4254
Query: 789 SGNPQQYHPVPLTG---RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTV 845
+PL G R Q L N SL I +D G Y C A N +G K + L +
Sbjct: 4255 -------DGLPLRGSHLRHQ-LQNGSLTIHRTERDDAGRYQCLAENEMGV-AKKVVILVL 4305
Query: 846 KIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNG 905
+ + P G L C A GE I W + + R +R T +G
Sbjct: 4306 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLR----TLPDG 4361
Query: 906 DEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
+L L+ + GD+ + C A N G L V+ P
Sbjct: 4362 -----SLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 4399
Score = 181 bits (460), Expect = 5e-45
Identities = 307/1422 (21%), Positives = 504/1422 (35%), Gaps = 195/1422 (13%)
Query: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAE 166
C G P + W + ++HV A G L + A + Y C
Sbjct: 2184 CECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLA-----QEGTYTCECS 2238
Query: 167 NAAGKIRSPNIRVK-------AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVV 219
N G S +++++ A REP T ++ VA +C ++ + V
Sbjct: 2239 NVVGN-SSQDLQLEVHVPPQIAGPREPPT----QVSVVQDGVATLEC---NATGKPPPTV 2290
Query: 220 SWEKDTVSIIPEHRFFITYHG-GLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSV 278
+WE+D + E + G L++ Q Y C+ ++ R+ LSV
Sbjct: 2291 TWERDGQPVGAELGLQLQNQGQSLHVERAQAAHT-GRYSCVAENLAGRAERKFE---LSV 2346
Query: 279 TDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG 338
P E I LD + + L C A G P PAIRW + P+ + T + G
Sbjct: 2347 LVPPELIGD-LDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPV-SPGEDTYLLAG 2404
Query: 339 ---LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKK--LKTGIGSTVI 393
L ++ + +DSG Y C +N G A + V+ P + + +K G T
Sbjct: 2405 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAH 2464
Query: 394 LSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKA- 452
L C +TG P+ + W+++ + +A I L + A S +G Y C A
Sbjct: 2465 LMCNVTGHPQPKLTWFKDGRPLARGDAHHISP-DGVLLQVLQANLSSAGHYSCIAANAVG 2523
Query: 453 QTAQDFAIIALEDGTPRIV-----SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEP 507
+ + F + L P I+ S+ E V SL+C A P P +TW D P
Sbjct: 2524 EKTKHFQLSVLL--APTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP 2581
Query: 508 IVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS 567
+ + GT + + Q D G Y C N +G A + V PPS
Sbjct: 2582 F-----EASRNIQLLPGT--HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 2634
Query: 568 IR--------AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDAL-LLPDNHRQVVFENGT 618
I ++ + + C P +I+WYKD + P + QV+ E
Sbjct: 2635 ISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL 2694
Query: 619 LKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPF---------------- 662
L++ Q D G YLC V Q +V ++VPP+ Q
Sbjct: 2695 LQIQPTQVS-DSGRYLC-VATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEA 2752
Query: 663 -----EFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQIS 717
E+ Y+ C ++ P +TW ++ Q + +G V++ + LQI
Sbjct: 2753 RGGVTEYREIVENNPAYLYCDTNAIPPP-DLTWYREDQPLSAGDEVSVLQGGRV--LQIP 2809
Query: 718 SVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIY------GKAGVLNC 771
V ++ G Y+C ASN +L+V PP V+ + ++ + L C
Sbjct: 2810 LVRAENAGRYSCKASNEVGEDWLHYELLVLTPP--VILGDTEELVEEVTVNASSTVSLQC 2867
Query: 772 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLE-EDIGYYLCQAS 830
G P P + W N + P P R+Q+L + +L E D Y+C A
Sbjct: 2868 PALGNPVPTISWLQ-----NGLPFSPSP---RLQVLEDGQVLQVSTAEVADAASYMCVAE 2919
Query: 831 NGVGTDISKSMFLTVKIPAMITSHPNTTI-AIKGHAKELNCTARGERPIIIRWEKGDTVI 889
N G+ K L V++P I + AI + L C + W K +
Sbjct: 2920 NQAGS-AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQAL 2978
Query: 890 DPDRVMRYAIATKDNGDEV-----VSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTV 944
G+EV TL+L A DS ++C A+N+ G D+ L+QL+V
Sbjct: 2979 SL-------------GEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSV 3025
Query: 945 QEPP-------DPPELEIREVKARSMNLRWTQRFDGNSII---TGFDIEYKNKSDSWDFK 994
PP P + + V +++ T ++ G + ++ +
Sbjct: 3026 LVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGG 3085
Query: 995 QSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVT 1054
Q ++ + ++V + +F + P+ E + + G P+ +T
Sbjct: 3086 QRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLT 3145
Query: 1055 LQPVTSQSIQVTWKAPKKELQNGVI-----RGYQIGYRENSPGSNGQYSIVEMKATGDSE 1109
+ VTW + +++ + RG ++ P G Y+ V ++
Sbjct: 3146 CDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR 3205
Query: 1110 VYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLE---DVPSQPPENVRALSITSDV 1166
K F +V +G + + + QPP DV
Sbjct: 3206 -------KDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPP---------DV 3249
Query: 1167 AVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQ 1226
A + P + L+ Y+DG + L+G+ +
Sbjct: 3250 AWLKDGSPLGQDMGPHLR--------FYLDGG------------SLVLKGLRASDAGAYT 3289
Query: 1227 VLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTI 1286
+A+ AG+ R + + + G + S +V P V I
Sbjct: 3290 CVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCP------VRGSPPI 3343
Query: 1287 FCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAA----VTSAGRGNSSEKVTI 1342
S G P P T L + H R + L A V ++ G + T+
Sbjct: 3344 HVSWLKDGLPLPLSQRT----LLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTL 3399
Query: 1343 EPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLI 1402
+ + + F V V LPC + G P P V W KD E + +
Sbjct: 3400 QVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLL-------SQSL 3452
Query: 1403 HTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP 1444
+L L AV A DSG Y+C A + G L V PP
Sbjct: 3453 EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP 3494
Score = 177 bits (448), Expect = 1e-43
Identities = 215/887 (24%), Positives = 343/887 (38%), Gaps = 115/887 (12%)
Query: 98 SSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIH 157
+ V +PC A+G P+ + W T PH +V GTL + PSA ++
Sbjct: 988 NEGVPASLPCVASGVPAPTITWTKETNALTSRGPHY-NVSKEGTLLIA--QPSAQDA--- 1041
Query: 158 DNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVS 217
Y CTA N G ++ R +A+ K YV
Sbjct: 1042 -GAYVCTATNTVG------------------FSSQEMRLSVNRLALSK---------YV- 1072
Query: 218 VVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
WE+ ++P G L ++ VQ D+ Y C + S+ L
Sbjct: 1073 ---WEE--YGLLPS--------GSLRLAQVQVGDS-GHYECTASNPAGSA---SHRYVLG 1115
Query: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337
V P P + G +V G ++L C A G P P + W KDG L
Sbjct: 1116 VQVP----PQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGS--- 1168
Query: 338 GLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH--VTLTPKKLKTGIGSTVILS 395
+ + +RT D+G Y CE +N+ G L V++P H T L+ G L
Sbjct: 1169 -VHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLP 1227
Query: 396 CALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTA 455
C G+P+ + W + + L +L + S + SG Y+C AT + +
Sbjct: 1228 CPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 1287
Query: 456 QDFAIIAL-------EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 508
A + + EDG VS + G+ +L C A G P P + W D + +
Sbjct: 1288 SRRAKLVVYVPPSIREDGRKANVSGMA------GQSLTLECDANGFPVPEIVWLKDAQLV 1341
Query: 509 VRDGSHRTNQYTMSDGTTISH------MNVTGPQIRDG--GVYRCTARNLVGSAEYQARI 560
+ + G H ++ P+I++G G+Y C A N G+A+ +
Sbjct: 1342 GVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHL 1401
Query: 561 NVRGPPSIR---AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDAL-LLPDN-HRQVVFE 615
V PPS+ A + + +AG D + C G P ++W KD +LP H QV +
Sbjct: 1402 LVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQED 1461
Query: 616 NGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPF-EFPPASIGQLLY 674
L++T G DEG Y C V P ++ + V PP I E ++ +
Sbjct: 1462 GQVLRITGSHVG-DEGRYQC-VAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHL 1519
Query: 675 IPCVVSSGDMPI-RITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASN 733
+ + + +P ITW KDG ++ + + V LQ+ G YTC ASN
Sbjct: 1520 VQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGG--RQLQLGRAQSSDAGVYTCKASN 1577
Query: 734 AAATVSRERQLIVRVPPRFV---VQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSG 790
A + +L V VPP +P + G+ L C G+P P + W H
Sbjct: 1578 AVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHH----- 1632
Query: 791 NPQQYHPVPLTGRIQILPNSSLL-IRHVLEEDIGYYLCQASNGVGTDISK-SMFLTVKIP 848
+ PV + ++ + S+L + E G Y C AS+ G + + S+ + V
Sbjct: 1633 ---EGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQ 1689
Query: 849 AMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEV 908
++ I G EL C A G I+W + + + +A++
Sbjct: 1690 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEELAGVQVASQG----- 1742
Query: 909 VSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEI 955
+TL + + S F+C A N G ++++V P LE+
Sbjct: 1743 -TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEV 1788
Score = 177 bits (448), Expect = 1e-43
Identities = 224/917 (24%), Positives = 346/917 (37%), Gaps = 108/917 (11%)
Query: 105 VPCPAAGSPSAALRWYLA-TGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFC 163
+PCPA G+P + W + + ++ P + V G+L L SP+ DY C
Sbjct: 1226 LPCPARGTPKPQVTWRKGPSSEPLHGQPGVA-VLEEGSLFLASVSPA------DSGDYEC 1278
Query: 164 TAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEY-VSVVSWE 222
A N G S + R K V P ++R + +++ +A + + V + W
Sbjct: 1279 QATNEVG---STSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWL 1335
Query: 223 KDTVSI-----------------IPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYS 265
KD + + HR + L+ +Q+ D+ Y C +++
Sbjct: 1336 KDAQLVGVPLGWAGYGWDLGWGQVGGHRL-LDEGQSLHFPRIQEGDS-GLYSCRAENQAG 1393
Query: 266 GETRQSNGARLSVTDPAESIPTILDGFHSQEVW--AGHTVELPCTASGYPIPAIRWLKDG 323
R + L V P P++L +QEV AG VEL C SG P P + W KD
Sbjct: 1394 TAQRDFH---LLVLTP----PSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDR 1446
Query: 324 RP-LPADSRWTKRITG--LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLT 380
+P LP + G L I+ D G Y C + G L V P + +
Sbjct: 1447 QPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGS 1506
Query: 381 PKKLKTGI--GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQK 438
+ + + V L C G P I W+++ L LP + L + AQ
Sbjct: 1507 NETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL-LPTSTKVVYTRGGRQLQLGRAQS 1565
Query: 439 SHSGAYQCFATRKAQTAQDFAIIAL--------EDGTPRIVSSFSEKVVNPGEQFSLMCA 490
S +G Y C A+ A+ + + G P +V + + G +L C
Sbjct: 1566 SDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA------GRPVALECV 1619
Query: 491 AKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNL 550
A+G P PT++W + P+ R +DG+ + + P G+Y C A +
Sbjct: 1620 ARGHPSPTLSWHHEGLPVAESNESRLE----TDGSVL---RLESPGEASSGLYSCVASSP 1672
Query: 551 VGSAEYQARINVRGPPSI---RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPD 607
G A Q + V+ PP + + +T + G+ + C+ G P +I+W ++ +
Sbjct: 1673 AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEE 1732
Query: 608 NHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPA 667
V GT D + G + C + + ++ V V+V E P
Sbjct: 1733 LAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE-VEVSVHGEWAPGVLEVP-- 1789
Query: 668 SIGQLLY-------IPCVV---------SSGDMPIRITWRKDGQVIISGSGVTIESKEFM 711
IGQ + P + P+ W G + +G+ + +
Sbjct: 1790 -IGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPV-AYSLP 1847
Query: 712 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC 771
LQI V L+ G YTC A+N A RE L V VPP P N+ + + L C
Sbjct: 1848 PPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLEC 1907
Query: 772 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN 831
G PPP V W + V + GR+ L I D G Y C ASN
Sbjct: 1908 LASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV-------LRIEQAQLSDAGSYRCVASN 1960
Query: 832 GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAK-ELNCTARGERPIIIRWEKGDTVID 890
G+ L V +P IT P+ + + L C A G + W K +
Sbjct: 1961 VAGS-TELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVS 2019
Query: 891 PDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPD- 949
P + G V L L A DS +SC A+++ GEDR + L V PP
Sbjct: 2020 PAGTPGLQVFP---GGRV---LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI 2073
Query: 950 -PPELEIREVKARSMNL 965
EL + V S+ L
Sbjct: 2074 LGEELNVSVVANESVAL 2090
Score = 163 bits (413), Expect = 1e-39
Identities = 164/632 (25%), Positives = 243/632 (38%), Gaps = 39/632 (6%)
Query: 339 LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCAL 398
L I + D G Y C TN G ++ L V+ P ++ P ++V L C
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 1909
Query: 399 TGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDF 458
+G P + W++ + V +++ + L I AQ S +G+Y+C A+ A + +
Sbjct: 1910 SGVPPPDVSWFKGHQPVSSWMGVTV-SVDGRVLRIEQAQLSDAGSYRCVASNVAGST-EL 1967
Query: 459 AIIALEDGTPRIVSSFS-EKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTN 517
+ PRI S V L C A GAP PT+ W D P+ G+
Sbjct: 1968 RYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQ 2027
Query: 518 QYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMR-NITA 576
+ T++ + D G Y C A + VG + V PPSI N++
Sbjct: 2028 VFPGGRVLTLASARAS-----DSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSV 2082
Query: 577 VAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCS 636
VA + C+ P + W+KD L + + L D D G Y C
Sbjct: 2083 VANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCE 2142
Query: 637 VLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI--GQLLYIPCVVSSGDMPIRITWRKDG 694
L Q S + ++ V V P+ E ++ G + C P +I+WRKDG
Sbjct: 2143 ALNQAGHS-EKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFP-KISWRKDG 2200
Query: 695 QVIISGSGVTIESKEFMSS-LQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFV 753
Q + G G ++ + L + L G YTC SN S++ QL V VPP+
Sbjct: 2201 QP-LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIA 2259
Query: 754 ---VQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQIL-PN 809
P + L C+ G PPP V W+ + PV +Q+
Sbjct: 2260 GPREPPTQVSVVQDGVATLECNATGKPPPTVTWE--------RDGQPVGAELGLQLQNQG 2311
Query: 810 SSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITS--HPNTTIAIKGHAK- 866
SL + G Y C A N G + L+V +P + P T I H+
Sbjct: 2312 QSLHVERAQAAHTGRYSCVAENLAGR-AERKFELSVLVPPELIGDLDPLTNITAALHSPL 2370
Query: 867 ELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFS 926
L C A G P IRW +G+ + P Y +A LK+ DS +S
Sbjct: 2371 TLLCEAMGIPPPAIRWFRGEEPVSPGE-DTYLLAGG-------WMLKMTQTQEQDSGLYS 2422
Query: 927 CHAINSYGEDRGLIQLTVQEPPDPPELEIREV 958
C A N GE R + V PP ++ EV
Sbjct: 2423 CLASNEAGEARRNFSVEVLVPPSIENEDLEEV 2454
Score = 155 bits (392), Expect = 4e-37
Identities = 187/764 (24%), Positives = 304/764 (39%), Gaps = 61/764 (7%)
Query: 95 VTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNS 154
V S + ++PC A G P+ + W P + G+L++ P
Sbjct: 3682 VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE-ILPEGSLRIQPVLAQ---- 3736
Query: 155 FIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNV-AVFKCLIPSSVQ 213
Y C A N+AG R R V P ++ + A+ C S +
Sbjct: 3737 --DAGHYLCLASNSAGSDRQG--RDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPK 3792
Query: 214 EYVSVVSWEKDTVSI---IPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQ 270
+V W KD + + + + + L ++ +D+ + + C+ ++ GE +
Sbjct: 3793 P---LVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDS-AQFECVVSNEV-GEAHR 3847
Query: 271 SNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPA-D 329
+ V PTI D V V L C ++G P P + W K G L A
Sbjct: 3848 LYQVTVHVP------PTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARG 3901
Query: 330 SRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGI 388
S + +G L I +G Y C N+ G A L V V P ++
Sbjct: 3902 SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVA 3961
Query: 389 GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA 448
V+L C +G P TI W + V +S + L L I A +G Y C A
Sbjct: 3962 EEEVLLPCEASGIPRPTITWQKEGLNVAT--GVSTQVLPGGQLRIAHASPEDAGNYLCIA 4019
Query: 449 TRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 508
A +A + ++ P I + + G L C A+G+P P +TW D +P+
Sbjct: 4020 KNSAGSAMGKTRLVVQV-PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPV 4078
Query: 509 VRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI 568
S ++T+ + N+ G +D G Y CTA N VG A + + + P
Sbjct: 4079 ----SGAEGKFTIQPSGELLVKNLEG---QDAGTYTCTAENAVGRARRRVHLTILVLPVF 4131
Query: 569 RAMRNITAVAGRDTL-INCRVIGYPYYSIKWYKDALLLPDNHRQVVFENG--TLKLTDVQ 625
+ ++ D L + C G P I W + + + V ++G TL+ V
Sbjct: 4132 TTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG---VSEQDGGSTLQRAAVS 4188
Query: 626 KGMDEGEYLCSVLIQPQLSISQSVH-VAVKVPPLIQ--PFEFPPASIGQLLYIPCVVSSG 682
+ D G Y+C + ++ +Q+V V VK P++Q F + +G + + CVV
Sbjct: 4189 RE-DSGTYVCWA--ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD 4245
Query: 683 DMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRER 742
+P I W KDG + + GS + + + SL I G Y C+A N +
Sbjct: 4246 PVP-DIHWIKDG-LPLRGSHLRHQLQN--GSLTIHRTERDDAGRYQCLAENEMGVAKKVV 4301
Query: 743 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
L+++ P F V+P + G L C G P P + W A P+ +
Sbjct: 4302 ILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAG--------QPLRASR 4353
Query: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVK 846
R++ LP+ SL + +V D G Y C A N +G+ +++ FL V+
Sbjct: 4354 RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARA-FLVVR 4396
Score = 154 bits (390), Expect = 7e-37
Identities = 156/611 (25%), Positives = 257/611 (42%), Gaps = 51/611 (8%)
Query: 348 DSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIR 407
+ GTY C + G+ A ++V DP + + G T +LSC + G + +
Sbjct: 490 EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT 549
Query: 408 WYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGT 467
W R+ VLP + L++ +L I+ + G YQC A+ A ++ L
Sbjct: 550 WVRDWR-VLPASTGRVAQLADLSLEISGIIPTDGGRYQCVAS-NANGVTRASVWLLVREA 607
Query: 468 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTI 527
P++ S + + G + + C+A G P P ++W+ + + + D + + + GT I
Sbjct: 608 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED----SRIHVDAQGTLI 663
Query: 528 SHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVA-GRDTLINC 586
+ G D G Y C A N VG+ + + PPS+ A+ + VA G + ++ C
Sbjct: 664 ----IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 719
Query: 587 RVIGYPYYSIKWYK---DALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL 643
G P + WY+ + +L P+ +G L++ Q+ D G Y C +
Sbjct: 720 EASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQE-RDAGTYTCRA-VNELG 772
Query: 644 SISQSVHVAV-KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRK-DGQV--IIS 699
S + +AV P L + +G+ + C ++G P +TWR+ DGQ +
Sbjct: 773 DASAEIQLAVGHAPQLTELPRDVTVELGRSALLAC-RATGRPPPTVTWRRGDGQPLGLRL 831
Query: 700 GSGVTIESKEFMSS-LQISSVSLKHNGNYTCIASNAAATVSRERQLIV--RVPPRFVVQP 756
G+G S++ S L SV+ + Y C A N V E +LIV PP+
Sbjct: 832 GAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSA 891
Query: 757 NNQDGIYGKAGVLNCSV-DGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIR 815
+ G+ L C V G P P+ W + P+P R I + SL +
Sbjct: 892 PTVRVLEGQPVSLPCIVLAGRPLPERHWL--------KDGRPLPPGSRHSIRADGSLHLD 943
Query: 816 HVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTT--IAIKGHAKELNCTAR 873
L+E G Y C A+N G+ + + L V++P I HP T I +G L C A
Sbjct: 944 RALQEHAGRYSCVATNTAGSQ-HRDVELVVQVPPRI--HPTATHHITNEGVPASLPCVAS 1000
Query: 874 GERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSY 933
G I W K +T R Y ++ + TL + D+ + C A N+
Sbjct: 1001 GVPAPTITWTK-ETNALTSRGPHYNVSKE-------GTLLIAQPSAQDAGAYVCTATNTV 1052
Query: 934 GEDRGLIQLTV 944
G ++L+V
Sbjct: 1053 GFSSQEMRLSV 1063
Score = 146 bits (369), Expect = 2e-34
Identities = 145/563 (25%), Positives = 231/563 (41%), Gaps = 36/563 (6%)
Query: 392 VILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRK 451
+++SC++ + F ++ R E L +E + N + I A K+ G Y+C A +
Sbjct: 444 LLVSCSVHSALPFRLQ-LRRGEARLGEER-HFQESGNSSWEILRASKAEEGTYECTAVSR 501
Query: 452 AQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRD 511
A T + A I + D P++V + V+PGE L C G P +TW D +
Sbjct: 502 AGTGRAKAQIVVTDPPPQLVPA-PNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS 560
Query: 512 GSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAM 571
+S + ++G DGG Y+C A N G + VR P +
Sbjct: 561 TGRVAQLADLS-------LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIH 613
Query: 572 RNITAVA-GRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDE 630
+ + G + ++C GYP I W +++ L ++ R V GTL + V D
Sbjct: 614 TSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAP-EDA 672
Query: 631 GEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFE-FPPASIGQLLYIPCVVSSGDMPIRIT 689
G Y C + ++V + PP + ++G+ + C +SG P R+
Sbjct: 673 GNYSCQATNEVGTD-QETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVPPPRVI 730
Query: 690 WRKDG-QVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV 748
W + G ++I++ G + L+I + + G YTC A N S E QL V
Sbjct: 731 WYRGGLEMILAPEGSS------SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGH 784
Query: 749 PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILP 808
P+ P + G++ +L C G PPP V W+ +G G P G P
Sbjct: 785 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWR--RGDGQPLGLRLGAGRGSRSRQP 842
Query: 809 NSSLL-IRHVLEEDIGYYLCQASNGVG-TDISKSMFLTVKIPAMITSHPNTTIAIKGHAK 866
+S +L V ED Y+C+A N G + +T P I S T ++G
Sbjct: 843 DSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPV 902
Query: 867 ELNCTARGERPIIIR-WEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFF 925
L C RP+ R W K + P R++I +L L A + + +
Sbjct: 903 SLPCIVLAGRPLPERHWLKDGRPLPPG--SRHSIRAD-------GSLHLDRALQEHAGRY 953
Query: 926 SCHAINSYGEDRGLIQLTVQEPP 948
SC A N+ G ++L VQ PP
Sbjct: 954 SCVATNTAGSQHRDVELVVQVPP 976
Score = 145 bits (366), Expect = 4e-34
Identities = 164/675 (24%), Positives = 280/675 (41%), Gaps = 57/675 (8%)
Query: 91 SLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPS 150
S +T ++ ++PC A+GSP + W+ D + G +L P +
Sbjct: 3769 SPSNLTLTAHTPALLPCEASGSPKPLVVWWK-------DGQKLDFRLQQGAYRLLPSNAL 3821
Query: 151 AFNS-FIHDNDYF-CTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLI 208
+ D+ F C N G+ + P T+ +DQ + L
Sbjct: 3822 LLTAPGPQDSAQFECVVSNEVGEAHR---LYQVTVHVPPTI-ADDQTDFTVTMMAPVVLT 3877
Query: 209 PSSVQEYVSVVSWEKDTVSIIPEHRFF-ITYHGGLYISDVQKEDALSTYRCITKHKYSGE 267
S VSW K + + ++ G L I A Y C ++ +G
Sbjct: 3878 CHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHA-GRYTCSARNS-AGV 3935
Query: 268 TRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLP 327
+ + + + +P+++ +EV LPC ASG P P I W K+G +
Sbjct: 3936 AHKHVFLTVQASPVVKPLPSVVRAVAEEEVL------LPCEASGIPRPTITWQKEGLNV- 3988
Query: 328 ADSRWTKRITG--LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLK 385
A T+ + G L I+ ED+G Y+C N+ GSA L+V P + L
Sbjct: 3989 ATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLS 4048
Query: 386 TGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 445
T GS L C GSPE I W ++ + V E S E LL+ + + +G Y
Sbjct: 4049 TTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE-LLVKNLEGQDAGTYT 4107
Query: 446 CFATR---KAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
C A +A+ I+ L P + ++ + G++ L CAA+G+P P + W
Sbjct: 4108 CTAENAVGRARRRVHLTILVL----PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 4163
Query: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562
++D P+ S + G+T+ V+ D G Y C A N VG + + ++V
Sbjct: 4164 VNDRPVTEGVSEQ------DGGSTLQRAAVSR---EDSGTYVCWAENRVGRTQAVSFVHV 4214
Query: 563 RGPPSIR--AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLK 620
+ P ++ A + G ++C V G P I W KD L L +H + +NG+L
Sbjct: 4215 KEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLT 4274
Query: 621 LTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAV-KVPPL--IQPFEFPPASIGQLLYIPC 677
+ ++ D G Y C L + ++ +++ V + V + P+ ++P + S G + + C
Sbjct: 4275 IHRTERD-DAGRYQC--LAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRS-GDDVALRC 4330
Query: 678 VVSSGDMPIRITWRKDGQVIISGSGV-TIESKEFMSSLQISSVSLKHNGNYTCIASNAAA 736
++G+ I W + GQ + + + T+ SL + +V G Y C+A N
Sbjct: 4331 -QATGEPTPTIEWLQAGQPLRASRRLRTLPD----GSLWLENVETGDAGTYDCVAHNLLG 4385
Query: 737 TVSRERQLIVRVPPR 751
+ + L+VR P+
Sbjct: 4386 SATARAFLVVRGEPQ 4400
Score = 118 bits (296), Expect = 5e-26
Identities = 94/390 (24%), Positives = 164/390 (42%), Gaps = 24/390 (6%)
Query: 564 GPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTD 623
G P + I + L++C V + ++ + L + N + ++
Sbjct: 426 GAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILR 485
Query: 624 VQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGD 683
K +EG Y C+ + + +++ V PP + P S G+ + C V G+
Sbjct: 486 ASKA-EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL-GE 543
Query: 684 MPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQ 743
P +TW +D +V+ + +G + + SL+IS + G Y C+ASNA
Sbjct: 544 APYNLTWVRDWRVLPASTGRVAQLADL--SLEISGIIPTDGGRYQCVASNANGVTRASVW 601
Query: 744 LIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGR 803
L+VR P+ + ++Q G ++CS GYP P + W ++ + R
Sbjct: 602 LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWS--------RESQALQEDSR 653
Query: 804 IQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKG 863
I + +L+I+ V ED G Y CQA+N VGTD +++ L P +++ + G
Sbjct: 654 IHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD-QETVTLYYTDPPSVSAVNAVVLVAVG 712
Query: 864 HAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSV 923
L C A G P + W +G + +A + + L++ A D+
Sbjct: 713 EEAVLVCEASGVPPPRVIWYRGG--------LEMILAPEGSSS---GKLRIPAAQERDAG 761
Query: 924 FFSCHAINSYGEDRGLIQLTVQEPPDPPEL 953
++C A+N G+ IQL V P EL
Sbjct: 762 TYTCRAVNELGDASAEIQLAVGHAPQLTEL 791
Score = 98.2 bits (243), Expect = 7e-20
Identities = 91/335 (27%), Positives = 136/335 (40%), Gaps = 20/335 (5%)
Query: 629 DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRI 688
DEG Y C+ S + V + V VPP I+P A + ++SG P +
Sbjct: 1859 DEGIYTCAATNLAGES-KREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDV 1917
Query: 689 TWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV 748
+W K Q + S GVT+ + L+I L G+Y C+ASN A + L V V
Sbjct: 1918 SWFKGHQPVSSWMGVTVSVDGRV--LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV 1975
Query: 749 PPRFVVQPNNQDGIYGKAGV-LNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQIL 807
PPR + P+ + V L C+ G P P +MW GNP P +Q+
Sbjct: 1976 PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK---DGNPVSPAGTP---GLQVF 2029
Query: 808 PNSSLL-IRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAK 866
P +L + D G Y C A + VG D + + L V +P I + +
Sbjct: 2030 PGGRVLTLASARASDSGRYSCVAVSAVGED-RQDVVLQVHMPPSILGEELNVSVVANESV 2088
Query: 867 ELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFS 926
L C + P ++ W K ++P R + A K + L++ AD D+ ++
Sbjct: 2089 ALECQSHAMPPPVLSWWKDGRPLEP-RPGVHLSADK-------ALLQVDRADVWDAGHYT 2140
Query: 927 CHAINSYGEDRGLIQLTVQEPPDPPELEIREVKAR 961
C A+N G L V P P E + R
Sbjct: 2141 CEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVR 2175
Score = 84.0 bits (206), Expect = 1e-15
Identities = 90/379 (23%), Positives = 146/379 (38%), Gaps = 28/379 (7%)
Query: 88 VNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPF 147
+ + L ++ + +PC A GSP + W G + + +G L +
Sbjct: 4040 IENGLPDLSTTEGSHAFLPCKARGSPEPNITWD-KDGQPVSGAEGKFTIQPSGELLVKNL 4098
Query: 148 SPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCL 207
+ Y CTAENA G+ R + + + +T D+ G+ +C
Sbjct: 4099 EGQDAGT------YTCTAENAVGRARR-RVHLTILVLPVFTTLPGDRSLRLGDRLWLRCA 4151
Query: 208 IPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG--LYISDVQKEDALSTYRCITKHKYS 265
S + W TV+ P GG L + V +ED+ TY C
Sbjct: 4152 ARGSP---TPRIGW---TVNDRPVTEGVSEQDGGSTLQRAAVSREDS-GTYVC------W 4198
Query: 266 GETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP 325
E R +S E+ + F G +++L C G P+P I W+KDG P
Sbjct: 4199 AENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 4258
Query: 326 LPADS-RWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKL 384
L R + LTI +D+G Y C N G A+ IL++ + P+ +
Sbjct: 4259 LRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDM 4318
Query: 385 KTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAY 444
G V L C TG P TI W + + + +R L + +L + + + +G Y
Sbjct: 4319 TVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASR--RLRTLPDGSLWLENVETGDAGTY 4376
Query: 445 QCFATR--KAQTAQDFAII 461
C A + TA+ F ++
Sbjct: 4377 DCVAHNLLGSATARAFLVV 4395
Score = 56.6 bits (135), Expect = 2e-07
Identities = 42/121 (34%), Positives = 54/121 (44%), Gaps = 10/121 (8%)
Query: 1346 GKAPAKIISFGGTVTTPWMKDVRLPCNSV-GDPAPAVKWTKDSEDSAIPVSMDGHRLIHT 1404
G AP +I S TV + V LPC + G P P W KD P+ I
Sbjct: 881 GHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGR----PLPPGSRHSIRA 936
Query: 1405 NGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWI 1464
+G+L L E +G Y+C ATNT G V L+VQVPP + T+ IT +
Sbjct: 937 DGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP-----RIHPTATHHITNEGV 991
Query: 1465 P 1465
P
Sbjct: 992 P 992
Score = 53.9 bits (128), Expect = 2e-06
Identities = 26/79 (32%), Positives = 43/79 (54%), Gaps = 4/79 (5%)
Query: 1366 DVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTA 1425
+V++ C++ G P P + W+++S+ + D + GTL+++ V ED+G Y+C A
Sbjct: 624 EVKVSCSASGYPTPHISWSRESQ----ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQA 679
Query: 1426 TNTGGFDTIIVNLLVQVPP 1444
TN G D V L PP
Sbjct: 680 TNEVGTDQETVTLYYTDPP 698
Score = 53.9 bits (128), Expect = 2e-06
Identities = 41/135 (30%), Positives = 62/135 (45%), Gaps = 9/135 (6%)
Query: 1311 RIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLP 1370
RIAH + A SAG ++ ++ P I + ++T LP
Sbjct: 4003 RIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQ----VPPVIENGLPDLSTTEGSHAFLP 4058
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVS-MDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTG 1429
C + G P P + W KD + PVS +G I +G LL++ ++ +D+G YTCTA N
Sbjct: 4059 CKARGSPEPNITWDKDGQ----PVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 4114
Query: 1430 GFDTIIVNLLVQVPP 1444
G V+L + V P
Sbjct: 4115 GRARRRVHLTILVLP 4129
Score = 53.5 bits (127), Expect = 2e-06
Identities = 55/213 (25%), Positives = 86/213 (40%), Gaps = 17/213 (7%)
Query: 1252 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR 1311
GPPA +V +A L P + +GV + P +E PE
Sbjct: 3678 GPPAVNVSVNQTA-------LLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRI 3730
Query: 1312 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC 1371
L + + L +A+ ++ + +EP AP+ + T TP + LPC
Sbjct: 3731 QPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS-NLTLTAHTPAL----LPC 3785
Query: 1372 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1431
+ G P P V W KD + + +RL+ +N LLL A +DS + C +N G
Sbjct: 3786 EASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSN-ALLLTAPGPQDSAQFECVVSNEVGE 3844
Query: 1432 DTIIVNLLVQVPP----DQPRLTVSKTSASSIT 1460
+ + V VPP DQ TV+ + +T
Sbjct: 3845 AHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLT 3877
Score = 50.4 bits (119), Expect = 2e-05
Identities = 38/137 (27%), Positives = 60/137 (43%), Gaps = 21/137 (15%)
Query: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
++V LPC + G P P + W K+ + A VS + G L + ED+G Y C
Sbjct: 3963 EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQ----VLPGGQLRIAHASPEDAGNYLCI 4018
Query: 1425 ATNTGGFDTIIVNLLVQVPP----DQPRLTVSKTSASSI----------TLTWIPGDNGG 1470
A N+ G L+VQVPP P L+ ++ S + + +TW D G
Sbjct: 4019 AKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITW---DKDG 4075
Query: 1471 SSIRGFVLQYSVDNSEE 1487
+ G ++++ S E
Sbjct: 4076 QPVSGAEGKFTIQPSGE 4092
Score = 49.7 bits (117), Expect = 3e-05
Identities = 52/217 (23%), Positives = 89/217 (41%), Gaps = 21/217 (9%)
Query: 1325 VAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWT 1384
V A A R + TIE AG P + + G + V L C + G P+P + W
Sbjct: 1579 VGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAG-------RPVALECVARGHPSPTLSWH 1631
Query: 1385 KDSEDSAIPVSMDGHRLIHTNGTLL-LRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP 1443
+ +PV+ + T+G++L L + SG Y+C A++ G + ++ VQVP
Sbjct: 1632 HEG----LPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVP 1687
Query: 1444 PDQPRLTVSKTSASSITLTW----IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERS 1499
P+L V++ T+ +P GS + + +EE V ++S +
Sbjct: 1688 ---PQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTT 1744
Query: 1500 FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHG 1536
+D ++ A N G+ +E HG
Sbjct: 1745 LHIDHVELDHSGLFACQATNEAGTAGAE--VEVSVHG 1779
Score = 47.4 bits (111), Expect = 2e-04
Identities = 36/121 (29%), Positives = 48/121 (39%), Gaps = 26/121 (21%)
Query: 1367 VRLPCNSVGDPAPAVKWTKDSEDSA----IPVSMDGHRLIHTNGTLLLRAVKAEDSGYYT 1422
V L C + G P P V W K + + + VS+DG L + + D+G Y
Sbjct: 1903 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGR-------VLRIEQAQLSDAGSYR 1955
Query: 1423 CTATNTGGFDTIIVNLLVQVPP---------------DQPRLTVSKTSASSITLTWIPGD 1467
C A+N G + L V VPP RLT + T A S TL W+
Sbjct: 1956 CVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDG 2015
Query: 1468 N 1468
N
Sbjct: 2016 N 2016
Score = 47.4 bits (111), Expect = 2e-04
Identities = 35/126 (27%), Positives = 55/126 (43%), Gaps = 13/126 (10%)
Query: 1321 YLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPA 1380
Y+ W A GR + V ++ A + S+ + P ++L C GDP P
Sbjct: 4195 YVCW--AENRVGRTQAVSFVHVKEAPVLQGEAFSY---LVEPVGGSIQLDCVVRGDPVPD 4249
Query: 1381 VKWTKDSEDSAIPVSMDGHRLIHT--NGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNL 1438
+ W KD + + G L H NG+L + + +D+G Y C A N G +V L
Sbjct: 4250 IHWIKDG------LPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVIL 4303
Query: 1439 LVQVPP 1444
++Q P
Sbjct: 4304 VLQSAP 4309
Score = 43.9 bits (102), Expect = 0.002
Identities = 24/77 (31%), Positives = 36/77 (46%), Gaps = 5/77 (6%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLL-LRAVKAEDSGYYTCTATN 1427
L C+ +PAP + W +D I + D H G L L+A+ DSG Y+CTA N
Sbjct: 3601 LECSVEAEPAPKITWHRDG----IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARN 3656
Query: 1428 TGGFDTIIVNLLVQVPP 1444
G ++ + + P
Sbjct: 3657 AAGSTSVAFRVEIHTVP 3673
Score = 43.1 bits (100), Expect = 0.003
Identities = 29/85 (34%), Positives = 40/85 (47%), Gaps = 3/85 (3%)
Query: 1360 TTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSG 1419
T M V L C+S G PAP V W+K + + G+R + +G L + +G
Sbjct: 3867 TVTMMAPVVLTCHSTGIPAPTVSWSK--AGAQLGARGSGYR-VSPSGALEIGQALPIHAG 3923
Query: 1420 YYTCTATNTGGFDTIIVNLLVQVPP 1444
YTC+A N+ G V L VQ P
Sbjct: 3924 RYTCSARNSAGVAHKHVFLTVQASP 3948
Score = 41.2 bits (95), Expect = 0.011
Identities = 24/79 (30%), Positives = 37/79 (46%), Gaps = 4/79 (5%)
Query: 1366 DVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTA 1425
DV L C + G+P P ++W + + P+ +G+L L V+ D+G Y C A
Sbjct: 4325 DVALRCQATGEPTPTIEWLQAGQ----PLRASRRLRTLPDGSLWLENVETGDAGTYDCVA 4380
Query: 1426 TNTGGFDTIIVNLLVQVPP 1444
N G T L+V+ P
Sbjct: 4381 HNLLGSATARAFLVVRGEP 4399
Score = 39.3 bits (90), Expect = 0.041
Identities = 48/209 (22%), Positives = 74/209 (35%), Gaps = 29/209 (13%)
Query: 1289 SSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKA 1348
S SG P P + Q + ++ Q L + V GN S + T E
Sbjct: 628 SCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQ 687
Query: 1349 ---------PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH 1399
P + + V ++ L C + G P P V W + + + + +G
Sbjct: 688 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMIL--APEGS 745
Query: 1400 RLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP---DQPR-------- 1448
++G L + A + D+G YTC A N G + + L V P + PR
Sbjct: 746 ----SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGR 801
Query: 1449 ---LTVSKTSASSITLTWIPGDNGGSSIR 1474
L T T+TW GD +R
Sbjct: 802 SALLACRATGRPPPTVTWRRGDGQPLGLR 830
Score = 38.1 bits (87), Expect = 0.092
Identities = 48/196 (24%), Positives = 68/196 (34%), Gaps = 31/196 (15%)
Query: 1272 LPPTKPNGVIRKYTIFCSSPGSGQPAP-----------SEYETSPEQLFYRIAHLNRGQQ 1320
LPP+ P V+ + + +G P+P S T Q+F G+
Sbjct: 1981 LPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVF------PGGRV 2034
Query: 1321 YLLWVAAVTSAGR---------GNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC 1371
L A + +GR G + V ++ P I+ V+ + V L C
Sbjct: 2035 LTLASARASDSGRYSCVAVSAVGEDRQDVVLQV--HMPPSILGEELNVSVVANESVALEC 2092
Query: 1372 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1431
S P P + W KD G L L + D+G+YTC A N G
Sbjct: 2093 QSHAMPPPVLSWWKDGRPLE---PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGH 2149
Query: 1432 DTIIVNLLVQVPPDQP 1447
NL V V P P
Sbjct: 2150 SEKHYNLNVWVAPVFP 2165
Score = 37.7 bits (86), Expect = 0.12
Identities = 23/79 (29%), Positives = 35/79 (44%), Gaps = 10/79 (12%)
Query: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTAT 1426
+ L C++ G P P + W KD + RL N + R ++ D+G YTC A
Sbjct: 3513 MELLCDAQGTPQPNITWHKDGQALT--------RL--ENNSRATRVLRVRDAGLYTCLAE 3562
Query: 1427 NTGGFDTIIVNLLVQVPPD 1445
+ G + VQ PP+
Sbjct: 3563 SPAGAIEKSFRVRVQAPPN 3581
Score = 37.0 bits (84), Expect = 0.20
Identities = 32/118 (27%), Positives = 46/118 (38%), Gaps = 5/118 (4%)
Query: 1408 LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKT--SASSITLTWIP 1465
L + V D G YTC ATN G V L V VPP+ V+K +S+TL +
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 1909
Query: 1466 GDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGS 1523
+ F V + W V +S R +++ + + A N GS
Sbjct: 1910 SGVPPPDVSWFKGHQPVSS---WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS 1964
Score = 35.4 bits (80), Expect = 0.60
Identities = 24/63 (38%), Positives = 27/63 (42%), Gaps = 7/63 (11%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVS-MDGHRLIHTNGTLLLRAVKAEDSGYYTCTATN 1427
L C + G P P + WT + VS DG TL AV EDSG Y C A N
Sbjct: 4148 LRCAARGSPTPRIGWTVNDRPVTEGVSEQDG------GSTLQRAAVSREDSGTYVCWAEN 4201
Query: 1428 TGG 1430
G
Sbjct: 4202 RVG 4204
Score = 34.3 bits (77), Expect = 1.3
Identities = 30/135 (22%), Positives = 55/135 (40%), Gaps = 7/135 (5%)
Query: 1310 YRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRL 1369
+ I ++ ++ AV+ AG G + ++ + P +++ +P V L
Sbjct: 481 WEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDP---PPQLVPAPNVTVSPGETAV-L 536
Query: 1370 PCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTG 1429
C +G+ + W +D +P S G + +L + + D G Y C A+N
Sbjct: 537 SCRVLGEAPYNLTWVRDWR--VLPAST-GRVAQLADLSLEISGIIPTDGGRYQCVASNAN 593
Query: 1430 GFDTIIVNLLVQVPP 1444
G V LLV+ P
Sbjct: 594 GVTRASVWLLVREAP 608
Score = 32.7 bits (73), Expect = 3.9
Identities = 25/101 (24%), Positives = 42/101 (41%), Gaps = 7/101 (6%)
Query: 1334 GNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIP 1393
G++S ++ + G AP ++ VT + L C + G P P V W + + +
Sbjct: 772 GDASAEIQLA-VGHAP-QLTELPRDVTVELGRSALLACRATGRPPPTVTWRR-GDGQPLG 828
Query: 1394 VSMDGHRLIHT----NGTLLLRAVKAEDSGYYTCTATNTGG 1430
+ + R + +G L +V ED Y C A N G
Sbjct: 829 LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFG 869
Score = 32.0 bits (71), Expect = 6.6
Identities = 23/70 (32%), Positives = 33/70 (47%), Gaps = 15/70 (21%)
Query: 1409 LLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQ----PRLTVSKTSASSIT---- 1460
+LRA KAE+ G Y CTA + G ++V PP Q P +TVS + ++
Sbjct: 483 ILRASKAEE-GTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 541
Query: 1461 ------LTWI 1464
LTW+
Sbjct: 542 GEAPYNLTWV 551
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 222 bits (565), Expect = 3e-57
Identities = 221/807 (27%), Positives = 334/807 (41%), Gaps = 69/807 (8%)
Query: 161 YFCTAENAAGK-IRS--PNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVS 217
Y C N AG+ +R+ ++V F P T V + G+ V C + S V
Sbjct: 1819 YSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQ---VAGSPLVLTCDV-SGVP--AP 1872
Query: 218 VVSWEKDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSGETRQSNGARL 276
V+W KD + + + GG L +S +Q A TY C+ ++ + E R+ +
Sbjct: 1873 TVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQA-GTYTCVAENTQA-EARKDFVVAV 1930
Query: 277 SVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADS----RW 332
V S + V G V L C A G P P + WLKDG PL D R+
Sbjct: 1931 LVAPRIRSSGVARE----HHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRF 1986
Query: 333 TKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGI---G 389
L + LR D+G Y C N G + V+ P + T + G
Sbjct: 1987 YLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 2046
Query: 390 STVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFAT 449
V + C + GSP + W ++ L LP ++ S TL I+ Q + +G + C A
Sbjct: 2047 ELVTMVCPVRGSPPIHVSWLKDG-LPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 2105
Query: 450 RKAQTA-QDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 508
A A ++F + V ++ VV G L C A+G P P V+W D EP+
Sbjct: 2106 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPL 2165
Query: 509 VRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI 568
+ ++ G ++ + G D G Y C A + G A ++ V PP I
Sbjct: 2166 LSQ--------SLEQGPSLQ-LEAVGAG--DSGTYSCVAVSEAGEARRHFQLTVMEPPHI 2214
Query: 569 RAMRNITAVA---GRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQ 625
T ++ G + C G P +I W+KD L EN + + T V
Sbjct: 2215 EDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTR------LENNS-RATRVL 2267
Query: 626 KGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQL---LYIPCVVSSG 682
+ D G Y C + P +I +S V V+ PP I P +G L + C V +
Sbjct: 2268 RVRDAGLYTC-LAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 2326
Query: 683 DMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRER 742
P +ITW +DG I+ + E LQ+ ++S +G+Y+C A NAA + S
Sbjct: 2327 PAP-KITWHRDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAF 2383
Query: 743 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
++ + P P + + +L C DG P P V W+ + +P+ +
Sbjct: 2384 RVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPR-------SP 2436
Query: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIK 862
R +ILP SL I+ VL +D G+YLC ASN G+D ++ PA+ S N T+
Sbjct: 2437 RFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2496
Query: 863 GHAKELNCTARGE-RPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGD 921
A L C A G +P+++ W+ G + + Y + + L L D
Sbjct: 2497 TPAL-LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPS-------NALLLTAPGPQD 2548
Query: 922 SVFFSCHAINSYGEDRGLIQLTVQEPP 948
S F C N GE L Q+TV PP
Sbjct: 2549 SAQFECVVSNEVGEAHRLYQVTVHVPP 2575
Score = 216 bits (550), Expect = 2e-55
Identities = 234/905 (25%), Positives = 360/905 (39%), Gaps = 113/905 (12%)
Query: 90 DSLQQVTFSSSVGVVVPCPAAGSPSAALRWY-----LATGDDIYDVPHIRHVHANGTLQL 144
D L +T + + + C A G P A+RW+ ++ G+D Y + A G +
Sbjct: 1075 DPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTY-------LLAGGWMLK 1127
Query: 145 YPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRS----MRGN 200
+ + Y C A N AG+ R N V+ + P ++ ED + G
Sbjct: 1128 MTQTQEQDSGL-----YSCLASNEAGEARR-NFSVEVLV--PPSIENEDLEEVIKVLDGQ 1179
Query: 201 VAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCIT 260
A C + Q ++ W KD + I+ G L + Y CI
Sbjct: 1180 TAHLMCNVTGHPQPKLT---WFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIA 1236
Query: 261 KHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQE-----VWAGHTVELPCTASGYPIP 315
+ +T+ +LSV PTIL G V + + L C A +P P
Sbjct: 1237 ANAVGEKTKHF---QLSVL----LAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSP 1289
Query: 316 AIRWLKDGRPLPADS--RWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVID 373
I W+KDG P A + GL I + + ED+G Y C VTN G A + V+
Sbjct: 1290 NITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI 1349
Query: 374 PLHVT-------LTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGL 426
P ++ + K++KT + ST+ L C P TIRWY++ + V P + + G
Sbjct: 1350 PPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLG- 1408
Query: 427 SNETLLITSAQKSHSGAYQCFATRKA-----------------QTAQDFA----IIALED 465
L I Q S SG Y C AT A Q DF+ I++ E+
Sbjct: 1409 EGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREE 1468
Query: 466 GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGT 525
V+ + E V N L C PPP +TW +D+P+ ++ ++ G
Sbjct: 1469 EARGGVTEYREIVEN--NPAYLYCDTNAIPPPDLTWYREDQPLSAG-----DEVSVLQGG 1521
Query: 526 TISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI-----RAMRNITAVAGR 580
+ + + + + G Y C A N VG + V PP I + +T A
Sbjct: 1522 RVLQIPLV--RAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS 1579
Query: 581 DTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQ 640
+ C +G P +I W ++ L + R V E+G + + D Y+C V
Sbjct: 1580 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMC-VAEN 1638
Query: 641 PQLSISQSVHVAVKVPPLIQ--PFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVII 698
S + + V+VPP I E A + + +PC V + P +TW KD Q +
Sbjct: 1639 QAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNP-EVTWYKDSQALS 1697
Query: 699 SGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNN 758
G V + +LQ+ L +G YTC A NAA + QL V VPP F P
Sbjct: 1698 LGEEVFL--LPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRG 1755
Query: 759 -QDGIYGKAG---VLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLL- 813
QD + + G VL+C D P P V W + P+ L R Q L L
Sbjct: 1756 PQDAVLVRVGDKAVLSCETDALPEPTVTWY--------KDGQPLVLAQRTQALRGGQRLE 1807
Query: 814 IRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIA-IKGHAKELNCTA 872
I+ D G Y C+ SN G + ++ LTV++P + T++ + G L C
Sbjct: 1808 IQEAQVSDKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV 1866
Query: 873 RGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINS 932
G + W K ++ V + + ++ + +L+PA G ++C A N+
Sbjct: 1867 SGVPAPTVTWLKDRMPVESSAV--HGVVSRGGR---LQLSRLQPAQAGT---YTCVAENT 1918
Query: 933 YGEDR 937
E R
Sbjct: 1919 QAEAR 1923
Score = 209 bits (532), Expect = 2e-53
Identities = 335/1485 (22%), Positives = 544/1485 (36%), Gaps = 270/1485 (18%)
Query: 103 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGT--LQLYPFSPSAFNSFIHDND 160
V + C A G+PS L W L G+ + GT LQ++P + +D
Sbjct: 713 VRLTCNATGAPSPTLMW-LKDGNPVSPA---------GTPGLQVFPGGRVLTLASARASD 762
Query: 161 ---YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVS 217
Y C A +A G+ R V V P + E S+ N +V L S
Sbjct: 763 SGRYSCVAVSAVGEDRQDV--VLQVHMPPSILGEELNVSVVANESV--ALECQSHAMPPP 818
Query: 218 VVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
V+SW KD + P ++ L D Y C ++ +G + + +
Sbjct: 819 VLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQ-AGHSEKHYNLNVW 877
Query: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337
V A P L H+ V GH L C G P P I W KDG+PLP + + ++
Sbjct: 878 V---APVFP--LRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVS 932
Query: 338 G----LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVT---LTPKKLKTGIGS 390
L + + GTY CE +N G++ L V P + P ++
Sbjct: 933 AVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDG 992
Query: 391 TVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATR 450
L C TG P T+ W R+ + V + + ++ ++L + AQ +H+G Y C A
Sbjct: 993 VATLECNATGKPPPTVTWERDGQPVGAELGLQLQN-QGQSLHVERAQAAHTGRYSCVAEN 1051
Query: 451 KAQTAQ---DFAIIALED--GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDD 505
A A+ + +++ + G +++ + + +P +L+C A G PPP + W +
Sbjct: 1052 LAGRAERKFELSVLVPPELIGDLDPLTNITAALHSP---LTLLCEAMGIPPPAIRWFRGE 1108
Query: 506 EPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGP 565
EP+ S + Y ++ G + +T Q +D G+Y C A N G A + V P
Sbjct: 1109 EPV----SPGEDTYLLAGGWM---LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP 1161
Query: 566 PSIR---AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLT 622
PSI I + G+ + C V G+P + W+KD L + +G L L
Sbjct: 1162 PSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVL-LQ 1220
Query: 623 DVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLI------QPFEFPPASIGQLLYIP 676
+Q + + + ++ ++V + P I E ++ + +
Sbjct: 1221 VLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLI 1280
Query: 677 CVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAA 736
C + P ITW KDG + I+ LQI + + G YTC+ +N
Sbjct: 1281 CEALAFPSP-NITWMKDGAPFEASR--NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1337
Query: 737 TVSRERQLIVRVPPRFVVQPNNQDGIYGKAGV------------LNCSVDGYPPPKVMWK 784
+ + V +PP ++D + GV L C PPP + W
Sbjct: 1338 EAVKNYHVEVLIPPSI-----SKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWY 1392
Query: 785 HAKGSGNPQQYHPVPLTGRIQILPNSSLL-IRHVLEEDIGYYLCQASNGVGTDISKSMFL 843
+ PV + R+Q+L LL I+ D G YLC A+N G D + +
Sbjct: 1393 --------KDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGED-DQDFNV 1443
Query: 844 TVKIPAMITSHPNTTIAIKGHAKE--------------------LNCTARGERPIIIRWE 883
+++P M + + A + ++E L C P + W
Sbjct: 1444 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 1503
Query: 884 KGD---------TVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYG 934
+ D +V+ RV++ + +N +SC A N G
Sbjct: 1504 REDQPLSAGDEVSVLQGGRVLQIPLVRAENAGR-----------------YSCKASNEVG 1546
Query: 935 EDRGLIQLTVQEPP----DPPELEIREVKARSMN---------------LRWTQRFDGNS 975
ED +L V PP D EL + EV + + + W Q N
Sbjct: 1547 EDWLHYELLVLTPPVILGDTEEL-VEEVTVNASSTVSLQCPALGNPVPTISWLQ----NG 1601
Query: 976 IITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPAS---VYSIRMYSFNKIGRSE 1032
+ + D + ST ++ + + + S ++++R+ +I +
Sbjct: 1602 LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLD 1661
Query: 1033 PSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNG----VIRG---YQIG 1085
+ I + P DV P + +VTW + L G ++ G Q+G
Sbjct: 1662 LEQVTAILNSSVS---LPCDVHAHP----NPEVTWYKDSQALSLGEEVFLLPGTHTLQLG 1714
Query: 1086 YRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVV-QAFNRAGTGPSSSEINAT 1144
S +G Y+ + A G + K Q V+V AF +A GP +
Sbjct: 1715 RARLS--DSGMYTCEALNAAGRDQ--------KLVQLSVLVPPAFRQAPRGPQDA----- 1759
Query: 1145 TLEDVPSQPPENVRALSITSDVAVISWSEP--PRSTLNGVLKGYRVIFWSLYVDGEWGEM 1202
L D AV+S P T + W Y DG
Sbjct: 1760 --------------VLVRVGDKAVLSCETDALPEPT----------VTW--YKDG----- 1788
Query: 1203 QNITTTRERVELRGMEKFTNYSVQV--------LAYTQAGDGVRSSVLYIQ--------- 1245
Q + + LRG ++ QV AG+ VR+ L +Q
Sbjct: 1789 QPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPK 1848
Query: 1246 --TKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYET 1303
T V G P + S + V+WL P + + G+ S +
Sbjct: 1849 TETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMP---VESSAVHGVVSRGGRLQLSRLQP 1905
Query: 1304 SPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPW 1363
+ + +A + + +V AV A R I +G A + G
Sbjct: 1906 AQAGTYTCVAENTQAEARKDFVVAVLVAPR--------IRSSGVAREHHVLEG------- 1950
Query: 1364 MKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH-RLIHTNGTLLLRAVKAEDSGYYT 1422
++VRL C + G P P V W KD S + M H R G+L+L+ ++A D+G YT
Sbjct: 1951 -QEVRLDCEADGQPPPDVAWLKDG--SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYT 2007
Query: 1423 CTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGD 1467
C A N G D + + V VPP T+ + + S TL PG+
Sbjct: 2008 CVAHNPAGEDARLHTVNVLVPP-----TIKQGADGSGTLVSRPGE 2047
Score = 204 bits (518), Expect = 1e-51
Identities = 210/812 (25%), Positives = 341/812 (41%), Gaps = 63/812 (7%)
Query: 161 YFCTAENAAGKI-RSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQ-EYVSV 218
Y C AE+ AG I +S +RV+A P V R + G +A + ++ SV+ E
Sbjct: 2275 YTCLAESPAGAIEKSFRVRVQA---PPNIVGPRGPRFVVG-LAPGQLVLECSVEAEPAPK 2330
Query: 219 VSWEKDTVSIIPE-HRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
++W +D + + + H F L + + D+ Y C T +G T S R+
Sbjct: 2331 ITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADS-GDYSC-TARNAAGST--SVAFRVE 2386
Query: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPL-PADSRWTKRI 336
+ ++PTI G + V T LPC A G P P + W KD PL P R+
Sbjct: 2387 I----HTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILP 2442
Query: 337 TG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILS 395
G L I + +D+G Y+C +N+ GS L V++P + +P L + +L
Sbjct: 2443 EGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLP 2502
Query: 396 CALTGSPEFTIRWYRNTE-LVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQT 454
C +GSP+ + W+++ + L + + R L + LL+T+ S ++C + +
Sbjct: 2503 CEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGE 2562
Query: 455 AQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH 514
A + + P I ++ V L C + G P PTV+W+ + GS
Sbjct: 2563 AHRLYQVTVHV-PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSG 2621
Query: 515 RTNQYTMSDGTTISHMNVTGPQIR-DGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRN 573
Y +S + G + G Y C+ARN G A + V+ P ++ + +
Sbjct: 2622 ----YRVSPSGALE----IGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPS 2673
Query: 574 IT-AVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632
+ AVA + L+ C G P +I W K+ L + V G L++ D G
Sbjct: 2674 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPE-DAGN 2732
Query: 633 YLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI--GQLLYIPCVVSSGDMPIRITW 690
YLC + S + V+VPP+I+ P S G ++PC P ITW
Sbjct: 2733 YLC-IAKNSAGSAMGKTRLVVQVPPVIEN-GLPDLSTTEGSHAFLPCKARGSPEP-NITW 2789
Query: 691 RKDGQVIISGSG-VTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVP 749
KDGQ + G TI+ L + ++ + G YTC A NA R L + V
Sbjct: 2790 DKDGQPVSGAEGKFTIQPS---GELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL 2846
Query: 750 PRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPN 809
P F P ++ G L C+ G P P++ W + P+T +
Sbjct: 2847 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGW----------TVNDRPVTEGVSEQDG 2896
Query: 810 SSLLIR-HVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKEL 868
S L R V ED G Y+C A N VG + S + P + + + G + +L
Sbjct: 2897 GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQL 2956
Query: 869 NCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCH 928
+C RG+ I W K + +R+ + NG +L ++ +R D+ + C
Sbjct: 2957 DCVVRGDPVPDIHWIKDGLPLRGSH-LRHQL---QNG-----SLTIRRTERDDAGRYQCL 3007
Query: 929 AINSYGEDRGLIQLTVQEPP----DPPELEIR 956
A N G + ++ L +Q P +P ++ +R
Sbjct: 3008 AENEMGVAKKVVILVLQSAPVFQVEPQDMTVR 3039
Score = 201 bits (512), Expect = 5e-51
Identities = 217/884 (24%), Positives = 356/884 (40%), Gaps = 84/884 (9%)
Query: 103 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYF 162
+ + C + P +RWY G + ++ + LQ+ P S Y
Sbjct: 1375 LTLECESWAVPPPTIRWY-KDGQPVTPSSRLQVLGEGRLLQIQPTQVS------DSGRYL 1427
Query: 163 CTAENAAGK--------IRSPNIRVKAV-FREPYTVRVEDQRSMRGNVAVFKCLIPSS-V 212
C A N AG+ I+ P + K F + + ++ + RG V ++ ++ ++
Sbjct: 1428 CVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEA-RGGVTEYREIVENNPA 1486
Query: 213 QEYVSV-------VSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYS 265
Y ++W ++ + + G + + + + Y C ++
Sbjct: 1487 YLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 1546
Query: 266 GETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP 325
+ L V P + + V A TV L C A G P+P I WL++G P
Sbjct: 1547 EDWLHYE---LLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLP 1603
Query: 326 LPADSRWTKRITG--LTISDLRTEDSGTYICEVTNTFGSAEATGILMV-IDPLHVTLTPK 382
R G L +S D+ +Y+C N GSAE L V + P L +
Sbjct: 1604 FSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLE 1663
Query: 383 KLKTGIGSTVILSCALTGSPEFTIRWYRNTE-LVLPDEAISIRGLSNETLLITSAQKSHS 441
++ + S+V L C + P + WY++++ L L +E + G TL + A+ S S
Sbjct: 1664 QVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPG--THTLQLGRARLSDS 1721
Query: 442 GAYQCFATRKAQTAQDFAIIALEDGTPRIVSSF-----SEKVVNPGEQFSLMCAAKGAPP 496
G Y C A A +D ++ L P +V G++ L C P
Sbjct: 1722 GMYTCEALNAA--GRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 1779
Query: 497 PTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEY 556
PTVTW D +P+V + RT + G + + Q+ D G+Y C N+ G A
Sbjct: 1780 PTVTWYKDGQPLVL--AQRTQ--ALRGG---QRLEIQEAQVSDKGLYSCKVSNVAGEAVR 1832
Query: 557 QARINVRGPPSIR--AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNH-RQVV 613
+ V+ PP+ ++ VAG ++ C V G P ++ W KD + + + VV
Sbjct: 1833 TFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVV 1892
Query: 614 FENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFP---PASIG 670
G L+L+ +Q G Y C V Q + VAV V P I+ G
Sbjct: 1893 SRGGRLQLSRLQPA-QAGTYTC-VAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEG 1950
Query: 671 QLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCI 730
Q + + C + G P + W KDG + G + SL + + G YTC+
Sbjct: 1951 QEVRLDC-EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCV 2009
Query: 731 ASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAG---VLNCSVDGYPPPKVMWKHAK 787
A N A +R + V VPP + + + G + C V G PP V W
Sbjct: 2010 AHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWL--- 2066
Query: 788 GSGNPQQYHPVPLTGRIQILPNS-SLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVK 846
+ P+PL+ R + + +L I V D G + C A++ G ++ L V+
Sbjct: 2067 -----KDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGV-ADRNFTLQVQ 2120
Query: 847 IPAMI--TSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDN 904
+P ++ N + ++G EL C ARG ++ W K D + ++ ++
Sbjct: 2121 VPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMK-----DGEPLLSQSL----- 2170
Query: 905 GDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
E +L+L+ GDS +SC A++ GE R QLTV EPP
Sbjct: 2171 --EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP 2212
Score = 201 bits (510), Expect = 8e-51
Identities = 221/890 (24%), Positives = 348/890 (39%), Gaps = 95/890 (10%)
Query: 87 FVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYP 146
F N + V+ + +V+ C +G P+ + W L + V G LQL
Sbjct: 1844 FENPKTETVSQVAGSPLVLTCDVSGVPAPTVTW-LKDRMPVESSAVHGVVSRGGRLQLSR 1902
Query: 147 FSPSAFNSFIHDNDYFCTAENAAGKIR---------SPNIRVKAVFREPYTVRVEDQRSM 197
P+ + Y C AEN + R +P IR V RE + + ++ R
Sbjct: 1903 LQPAQAGT------YTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVR-- 1954
Query: 198 RGNVAVFKCLIPSSVQEYVSVVSWEKDTVSI---IPEHRFFITYHGGLYISDVQKEDALS 254
L + + V+W KD + + H F G L + ++ DA
Sbjct: 1955 ---------LDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA-G 2004
Query: 255 TYRCITKHKYSGETRQSNGARLSVTDPAESIPTI---LDGFHSQEVWAGHTVELPCTASG 311
Y C+ H +GE + + + V PTI DG + G V + C G
Sbjct: 2005 AYTCVA-HNPAGEDARLHTVNVLVP------PTIKQGADGSGTLVSRPGELVTMVCPVRG 2057
Query: 312 YPIPAIRWLKDGRPLPADSRWTKRITG--LTISDLRTEDSGTYICEVTNTFGSAEATGIL 369
P + WLKDG PLP R +G L IS ++ D+G + C + G A+ L
Sbjct: 2058 SPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTL 2117
Query: 370 MVIDPLHVTLTPKKLKTGI----GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRG 425
V P L P + + + GS V L C G P + W ++ E +L
Sbjct: 2118 QVQVP--PVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL----- 2170
Query: 426 LSNETLLITSAQKSHSGAYQCFATRKA-QTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQ 484
+L + + SG Y C A +A + + F + +E +E + PG
Sbjct: 2171 EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAP 2230
Query: 485 FSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYR 544
L+C A+G P P +TW +DG T S T + ++RD G+Y
Sbjct: 2231 MELLCDAQGTPQPNITWH-------KDGQALTRLENNSRATRVL-------RVRDAGLYT 2276
Query: 545 CTARNLVGSAEYQARINVRGPPSI---RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKD 601
C A + G+ E R+ V+ PP+I R R + +A ++ C V P I W++D
Sbjct: 2277 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRD 2336
Query: 602 ALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQP 661
++L ++ E G D G+Y C+ S S + V + P I+
Sbjct: 2337 GIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTAR-NAAGSTSVAFRVEIHTVPTIR- 2394
Query: 662 FEFPPA---SIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISS 718
PPA S+ Q +PC P+ ++WRKD +V + E SL+I
Sbjct: 2395 -SGPPAVNVSVNQTALLPCQADGVPAPL-VSWRKD-RVPLDPRSPRFEILP-EGSLRIQP 2450
Query: 719 VSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPP 778
V + G+Y C+ASN+A + + R L V PP P+N +L C G P
Sbjct: 2451 VLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPK 2510
Query: 779 PKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDIS 838
P V+W + Q+ G ++LP+++LL+ +D + C SN VG +
Sbjct: 2511 PLVVWWK-----DGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVG-EAH 2564
Query: 839 KSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYA 898
+ +TV +P I L C + G + W K + R Y
Sbjct: 2565 RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGA-RGSGYR 2623
Query: 899 IATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
++ L++ A + ++C A NS G + LTVQ P
Sbjct: 2624 VSPS-------GALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP 2666
Score = 192 bits (487), Expect = 4e-48
Identities = 185/690 (26%), Positives = 279/690 (40%), Gaps = 65/690 (9%)
Query: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG--LTISD 343
P I G ++ V +V L C ASG P P + W K +P+ + T + G L I
Sbjct: 604 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQ 663
Query: 344 LRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGST-VILSCALTGSP 402
+ D+G+Y C +N GS E L V P +TL P + +T V L+C TG+P
Sbjct: 664 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAP 723
Query: 403 EFTIRWYRNTELVLPDEAISIRGL-SNETLLITSAQKSHSGAYQCFA-TRKAQTAQDFAI 460
T+ W ++ V P ++ L + SA+ S SG Y C A + + QD +
Sbjct: 724 SPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQD--V 781
Query: 461 IALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI-VRDGSHRTNQY 519
+ P I+ V E +L C + PPP ++W D P+ R G H +
Sbjct: 782 VLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADK 841
Query: 520 TMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPP--SIRAMRNITAV 577
+ + V + D G Y C A N G +E +NV P +R +T
Sbjct: 842 AL--------LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVR 893
Query: 578 AGRDTLINCRVIGYPYYSIKWYKDALLLPDNHR--QVVFENGTLKLTDVQKGMDEGEYLC 635
G T ++C G P+ I W KD LP Q V G L + EG Y C
Sbjct: 894 EGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTC 953
Query: 636 SVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIG----QLLYIPCVVSSGDMPIRITWR 691
S SQ + + V VPP I PP + + + C ++G P +TW
Sbjct: 954 ECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLEC-NATGKPPPTVTWE 1011
Query: 692 KDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPR 751
+DGQ + + G+ ++++ SL + H G Y+C+A N A R+ +L V VPP
Sbjct: 1012 RDGQPVGAELGLQLQNQG--QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPE 1069
Query: 752 FV--VQP-NNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILP 808
+ + P N L C G PPP + W + +P + + G +
Sbjct: 1070 LIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM---- 1125
Query: 809 NSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTI--AIKGHAK 866
L + E+D G Y C ASN G + ++ + V +P I + + + G
Sbjct: 1126 ---LKMTQTQEQDSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTA 1181
Query: 867 ELNCTARGERPIIIRWEK-------GDT-VIDPDRVMRYAIATKDNGDEVVSTLKLKPAD 918
L C G + W K GD I PD V+ L++ A+
Sbjct: 1182 HLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVL----------------LQVLQAN 1225
Query: 919 RGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
+ +SC A N+ GE QL+V P
Sbjct: 1226 LSSAGHYSCIAANAVGEKTKHFQLSVLLAP 1255
Score = 189 bits (481), Expect = 2e-47
Identities = 226/883 (25%), Positives = 344/883 (38%), Gaps = 119/883 (13%)
Query: 103 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYF 162
+V+ C P+ + W+ G + + H + LQL S + DY
Sbjct: 2317 LVLECSVEAEPAPKITWH-RDGIVLQEDAHTQFPERGRFLQLQALSTA------DSGDYS 2369
Query: 163 CTAENAAGKIRSPNIRVKAVFR-EPYTVRVEDQRSMRGNVAVFK-CLIPSSVQEY-VSVV 219
CTA NAAG FR E +TV NV+V + L+P +V
Sbjct: 2370 CTARNAAGS-------TSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLV 2422
Query: 220 SWEKDTVSIIPEH-RFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSV 278
SW KD V + P RF I G L I V +DA Y C+ + +G RQ G L V
Sbjct: 2423 SWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDA-GHYLCLASNS-AGSDRQ--GRDLRV 2478
Query: 279 TDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI-- 336
+P P I + + A LPC ASG P P + W KDG+ L D R +
Sbjct: 2479 LEP----PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKL--DFRLQQGAYR 2532
Query: 337 ----TGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTV 392
L ++ +DS + C V+N G A + V P + + + V
Sbjct: 2533 LLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPV 2592
Query: 393 ILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKA 452
+L+C TG P T+ W + L R + L I A H+G Y C A A
Sbjct: 2593 VLTCHSTGIPAPTVSWSK-AGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSA 2651
Query: 453 QTAQDFAIIALEDG-----TPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEP 507
A + ++ P +V + +E E+ L C A G P PT+TW +
Sbjct: 2652 GVAHKHVFLTVQASPVVKPLPSVVRAVAE------EEVLLPCEASGIPRPTITWQKEG-- 2703
Query: 508 IVRDGSHRTNQYTMSDGTTISHMNVTGPQIR-------DGGVYRCTARNLVGSAEYQARI 560
++ T +S + G Q+R D G Y C A+N GSA + R+
Sbjct: 2704 -------------LNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2750
Query: 561 NVRGPPSI-RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTL 619
V+ PP I + +++ G + C+ G P +I W KD + + +
Sbjct: 2751 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE 2810
Query: 620 KLTDVQKGMDEGEYLCSVLIQPQLSISQS---VHVAVKVPPLIQPFEFPPA-SIGQLLYI 675
L +G D G Y C+ + ++ ++ VH+ + V P+ + +G L++
Sbjct: 2811 LLVKNLEGQDAGTYTCTA----ENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWL 2866
Query: 676 PCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAA 735
C P RI W + + + G + ++ S+LQ ++VS + +G Y C A N
Sbjct: 2867 RCAARGSPTP-RIGWTVNDRPVTEG----VSEQDGGSTLQRAAVSREDSGTYVCWAENRV 2921
Query: 736 ATVSRERQLIVRVPP-------RFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKG 788
+ V+ P ++V+P G + L+C V G P P + W
Sbjct: 2922 GRTQAVSFVHVKEAPVLQGEAFSYLVEP------VGGSIQLDCVVRGDPVPDIHWIK--- 2972
Query: 789 SGNPQQYHPVPLTG---RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTV 845
+PL G R Q L N SL IR +D G Y C A N +G K + L +
Sbjct: 2973 -------DGLPLRGSHLRHQ-LQNGSLTIRRTERDDAGRYQCLAENEMGV-AKKVVILVL 3023
Query: 846 KIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNG 905
+ + P G L C A GE I W + + R +R T +G
Sbjct: 3024 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLR----TLPDG 3079
Query: 906 DEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
+L L+ + GD+ + C A N G L V+ P
Sbjct: 3080 -----SLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3117
Score = 181 bits (460), Expect = 5e-45
Identities = 307/1422 (21%), Positives = 504/1422 (35%), Gaps = 195/1422 (13%)
Query: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAE 166
C G P + W + ++HV A G L + A + Y C
Sbjct: 902 CECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLA-----QEGTYTCECS 956
Query: 167 NAAGKIRSPNIRVK-------AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVV 219
N G S +++++ A REP T ++ VA +C ++ + V
Sbjct: 957 NVVGN-SSQDLQLEVHVPPQIAGPREPPT----QVSVVQDGVATLEC---NATGKPPPTV 1008
Query: 220 SWEKDTVSIIPEHRFFITYHG-GLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSV 278
+WE+D + E + G L++ Q Y C+ ++ R+ LSV
Sbjct: 1009 TWERDGQPVGAELGLQLQNQGQSLHVERAQAAHT-GRYSCVAENLAGRAERKFE---LSV 1064
Query: 279 TDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG 338
P E I LD + + L C A G P PAIRW + P+ + T + G
Sbjct: 1065 LVPPELIGD-LDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPV-SPGEDTYLLAG 1122
Query: 339 ---LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKK--LKTGIGSTVI 393
L ++ + +DSG Y C +N G A + V+ P + + +K G T
Sbjct: 1123 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAH 1182
Query: 394 LSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKA- 452
L C +TG P+ + W+++ + +A I L + A S +G Y C A
Sbjct: 1183 LMCNVTGHPQPKLTWFKDGRPLARGDAHHISP-DGVLLQVLQANLSSAGHYSCIAANAVG 1241
Query: 453 QTAQDFAIIALEDGTPRIV-----SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEP 507
+ + F + L P I+ S+ E V SL+C A P P +TW D P
Sbjct: 1242 EKTKHFQLSVLL--APTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP 1299
Query: 508 IVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS 567
+ + GT + + Q D G Y C N +G A + V PPS
Sbjct: 1300 F-----EASRNIQLLPGT--HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 1352
Query: 568 IR--------AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDAL-LLPDNHRQVVFENGT 618
I ++ + + C P +I+WYKD + P + QV+ E
Sbjct: 1353 ISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL 1412
Query: 619 LKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPF---------------- 662
L++ Q D G YLC V Q +V ++VPP+ Q
Sbjct: 1413 LQIQPTQVS-DSGRYLC-VATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEA 1470
Query: 663 -----EFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQIS 717
E+ Y+ C ++ P +TW ++ Q + +G V++ + LQI
Sbjct: 1471 RGGVTEYREIVENNPAYLYCDTNAIPPP-DLTWYREDQPLSAGDEVSVLQGGRV--LQIP 1527
Query: 718 SVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIY------GKAGVLNC 771
V ++ G Y+C ASN +L+V PP V+ + ++ + L C
Sbjct: 1528 LVRAENAGRYSCKASNEVGEDWLHYELLVLTPP--VILGDTEELVEEVTVNASSTVSLQC 1585
Query: 772 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLE-EDIGYYLCQAS 830
G P P + W N + P P R+Q+L + +L E D Y+C A
Sbjct: 1586 PALGNPVPTISWLQ-----NGLPFSPSP---RLQVLEDGQVLQVSTAEVADAASYMCVAE 1637
Query: 831 NGVGTDISKSMFLTVKIPAMITSHPNTTI-AIKGHAKELNCTARGERPIIIRWEKGDTVI 889
N G+ K L V++P I + AI + L C + W K +
Sbjct: 1638 NQAGS-AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQAL 1696
Query: 890 DPDRVMRYAIATKDNGDEV-----VSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTV 944
G+EV TL+L A DS ++C A+N+ G D+ L+QL+V
Sbjct: 1697 SL-------------GEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSV 1743
Query: 945 QEPP-------DPPELEIREVKARSMNLRWTQRFDGNSII---TGFDIEYKNKSDSWDFK 994
PP P + + V +++ T ++ G + ++ +
Sbjct: 1744 LVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGG 1803
Query: 995 QSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVT 1054
Q ++ + ++V + +F + P+ E + + G P+ +T
Sbjct: 1804 QRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLT 1863
Query: 1055 LQPVTSQSIQVTWKAPKKELQNGVI-----RGYQIGYRENSPGSNGQYSIVEMKATGDSE 1109
+ VTW + +++ + RG ++ P G Y+ V ++
Sbjct: 1864 CDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR 1923
Query: 1110 VYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLE---DVPSQPPENVRALSITSDV 1166
K F +V +G + + + QPP DV
Sbjct: 1924 -------KDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPP---------DV 1967
Query: 1167 AVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQ 1226
A + P + L+ Y+DG + L+G+ +
Sbjct: 1968 AWLKDGSPLGQDMGPHLR--------FYLDGG------------SLVLKGLRASDAGAYT 2007
Query: 1227 VLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTI 1286
+A+ AG+ R + + + G + S +V P V I
Sbjct: 2008 CVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCP------VRGSPPI 2061
Query: 1287 FCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAA----VTSAGRGNSSEKVTI 1342
S G P P T L + H R + L A V ++ G + T+
Sbjct: 2062 HVSWLKDGLPLPLSQRT----LLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTL 2117
Query: 1343 EPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLI 1402
+ + + F V V LPC + G P P V W KD E + +
Sbjct: 2118 QVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLL-------SQSL 2170
Query: 1403 HTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP 1444
+L L AV A DSG Y+C A + G L V PP
Sbjct: 2171 EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP 2212
Score = 175 bits (444), Expect = 4e-43
Identities = 179/709 (25%), Positives = 285/709 (40%), Gaps = 91/709 (12%)
Query: 299 AGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTK--------RITGLTISD------- 343
AG ++ L C A+G+P+P I WLKD + + W ++ G + D
Sbjct: 32 AGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHF 91
Query: 344 --LRTEDSGTYICEVTNTFGSAEATGILMVIDPLHV--TLTPKKLKTGIGSTVILSCALT 399
++ DSG Y C N G+A+ L+V+ P V +++ G+ V L C +
Sbjct: 92 PRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTS 151
Query: 400 GSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKA-QTAQDF 458
G P + W ++ + VLP + L IT + G YQC A A Q A+DF
Sbjct: 152 GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDF 211
Query: 459 AIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQ 518
+ T + E V L+C A+G P P +TW +DG+
Sbjct: 212 QLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW-------FKDGALLPTS 264
Query: 519 YTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRN----I 574
+ + + Q D GVY C A N VG+AE R++V PP+I +
Sbjct: 265 TKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVV 324
Query: 575 TAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYL 634
AVAGR + C G+P ++ W+ + L + +++ + +G++ + G Y
Sbjct: 325 KAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYS 384
Query: 635 CSVLIQPQLSISQSVHVAVKVPPLIQPFE---FPPASIGQLLYIPCVVSSGDMPIRITWR 691
C V P V V+VPP + E +GQ L +PC S +P I W
Sbjct: 385 C-VASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVP-TIQWL 442
Query: 692 KDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQL------- 744
++G+ +GV + S+ ++L I V L H+G + C A+N A T E ++
Sbjct: 443 QNGRPAEELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWA 500
Query: 745 --IVRVP--------------PRFVVQPNNQD-GIYGKAGVLNCSVDGYPPPKVMWKHAK 787
++ VP P P ++ G + K + V+G+ P +W +
Sbjct: 501 PGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPL----VEGWCSPGSLW--GE 554
Query: 788 GSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI 847
+G P Y P L I V D G Y C A+N G + + + L V +
Sbjct: 555 PTGIPVAYSLPP-----------PLQIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLV 602
Query: 848 PAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDE 907
P I P ++ + L C A G P + W KG + + ++ +
Sbjct: 603 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGR----- 657
Query: 908 VVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPD---PPEL 953
L+++ A D+ + C A N G L V PP PP L
Sbjct: 658 ---VLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSL 703
Score = 171 bits (434), Expect = 5e-42
Identities = 205/883 (23%), Positives = 333/883 (37%), Gaps = 95/883 (10%)
Query: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAE 166
C A G P+ + W+ D + V+ G QL + ++ + Y C A
Sbjct: 242 CEARGVPTPNITWFK---DGALLPTSTKVVYTRGGRQLQLGRAQSSDAGV----YTCKAS 294
Query: 167 NAAGKIRSPNI-------RVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVV 219
NA G ++ PY V+ ++ G +C+ +
Sbjct: 295 NAVGAAEKATRLDVYVPPTIEGAGGRPYVVK-----AVAGRPVALECVARGHPSP---TL 346
Query: 220 SWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVT 279
SW + + + + + G + + E + Y C+ +GE + V
Sbjct: 347 SWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSP-AGEAVLQYSVEVQV- 404
Query: 280 DPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLP--ADSRWTKRIT 337
P + + + +G G +ELPC ASG P+P I+WL++GRP A + + T
Sbjct: 405 -PPQLL--VAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT 461
Query: 338 GLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIG-------- 389
L I + + SG + C+ TN G+A A V +H P L+ IG
Sbjct: 462 TLHIDHVELDHSGLFACQATNEAGTAGAE----VEVSVHGEWAPGVLEVPIGQYHWGXEH 517
Query: 390 -STVILSC--------ALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSH 440
S+ +C P W L I + L I
Sbjct: 518 HSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRD 577
Query: 441 SGAYQCFATRKA-QTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTV 499
G Y C AT A ++ ++ A+ L P I K V +L C A G PPP V
Sbjct: 578 EGIYTCAATNLAGESKREVALKVLV--PPNIEPGPVNKAVLENASVTLECLASGVPPPDV 635
Query: 500 TWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQAR 559
+W +P+ S DG + + Q+ D G YRC A N+ GS E +
Sbjct: 636 SWFKGHQPV----SSWMGVTVSVDGRV---LRIEQAQLSDAGSYRCVASNVAGSTELRYG 688
Query: 560 INVRGPPSIRAMRNI--TAVAGRDTLINCRVIGYPYYSIKWYKDA--LLLPDNHRQVVFE 615
+ V PP I ++ + + C G P ++ W KD + VF
Sbjct: 689 LRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFP 748
Query: 616 NGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI-GQLLY 674
G + + D G Y C V + Q V + V +PP I E + + + +
Sbjct: 749 GGRVLTLASARASDSGRYSC-VAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVA 807
Query: 675 IPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNA 734
+ C + P+ ++W KDG+ + GV + + + + LQ+ + G+YTC A N
Sbjct: 808 LECQSHAMPPPV-LSWWKDGRPLEPRPGVHLSADKAL--LQVDRADVWDAGHYTCEALNQ 864
Query: 735 AATVSRERQLIVRVPPRFVVQPNNQDGI-YGKAGVLNCSVDGYPPPKVMWKH----AKGS 789
A + L V V P F ++ ++ + G L+C G P PK+ W+ G
Sbjct: 865 AGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGE 924
Query: 790 GNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPA 849
G Q+ V GR+ L + L G Y C+ SN VG S+ + L V +P
Sbjct: 925 GAGLQH--VSAVGRLLYLGQAQL-------AQEGTYTCECSNVVGNS-SQDLQLEVHVPP 974
Query: 850 MIT---SHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGD 906
I P ++ L C A G+ P + WE+ + + + ++ G
Sbjct: 975 QIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAE----LGLQLQNQG- 1029
Query: 907 EVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPD 949
+L ++ A + +SC A N G +L+V PP+
Sbjct: 1030 ---QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPE 1069
Score = 163 bits (413), Expect = 1e-39
Identities = 164/632 (25%), Positives = 243/632 (38%), Gaps = 39/632 (6%)
Query: 339 LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCAL 398
L I + D G Y C TN G ++ L V+ P ++ P ++V L C
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 627
Query: 399 TGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDF 458
+G P + W++ + V +++ + L I AQ S +G+Y+C A+ A + +
Sbjct: 628 SGVPPPDVSWFKGHQPVSSWMGVTV-SVDGRVLRIEQAQLSDAGSYRCVASNVAGST-EL 685
Query: 459 AIIALEDGTPRIVSSFS-EKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTN 517
+ PRI S V L C A GAP PT+ W D P+ G+
Sbjct: 686 RYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQ 745
Query: 518 QYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMR-NITA 576
+ T++ + D G Y C A + VG + V PPSI N++
Sbjct: 746 VFPGGRVLTLASARAS-----DSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSV 800
Query: 577 VAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCS 636
VA + C+ P + W+KD L + + L D D G Y C
Sbjct: 801 VANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCE 860
Query: 637 VLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI--GQLLYIPCVVSSGDMPIRITWRKDG 694
L Q S + ++ V V P+ E ++ G + C P +I+WRKDG
Sbjct: 861 ALNQAGHS-EKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFP-KISWRKDG 918
Query: 695 QVIISGSGVTIESKEFMSS-LQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFV 753
Q + G G ++ + L + L G YTC SN S++ QL V VPP+
Sbjct: 919 QP-LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIA 977
Query: 754 ---VQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQIL-PN 809
P + L C+ G PPP V W+ + PV +Q+
Sbjct: 978 GPREPPTQVSVVQDGVATLECNATGKPPPTVTWE--------RDGQPVGAELGLQLQNQG 1029
Query: 810 SSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITS--HPNTTIAIKGHAK- 866
SL + G Y C A N G + L+V +P + P T I H+
Sbjct: 1030 QSLHVERAQAAHTGRYSCVAENLAGR-AERKFELSVLVPPELIGDLDPLTNITAALHSPL 1088
Query: 867 ELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFS 926
L C A G P IRW +G+ + P Y +A LK+ DS +S
Sbjct: 1089 TLLCEAMGIPPPAIRWFRGEEPVSPGE-DTYLLAGG-------WMLKMTQTQEQDSGLYS 1140
Query: 927 CHAINSYGEDRGLIQLTVQEPPDPPELEIREV 958
C A N GE R + V PP ++ EV
Sbjct: 1141 CLASNEAGEARRNFSVEVLVPPSIENEDLEEV 1172
Score = 160 bits (404), Expect = 2e-38
Identities = 182/717 (25%), Positives = 272/717 (37%), Gaps = 70/717 (9%)
Query: 286 PTILDGFHSQEVW--AGHTVELPCTASGYPIPAIRWLKDGRP-LPADSRWTKRITG--LT 340
P++L +QEV AG VEL C SG P P + W KD +P LP + G L
Sbjct: 125 PSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLR 184
Query: 341 ISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGI--GSTVILSCAL 398
I+ D G Y C + G L V P + + + + + V L C
Sbjct: 185 ITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEA 244
Query: 399 TGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDF 458
G P I W+++ L LP + L + AQ S +G Y C A+ A+
Sbjct: 245 RGVPTPNITWFKDGAL-LPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKA 303
Query: 459 AIIAL--------EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVR 510
+ + G P +V + + G +L C A+G P PT++W + P+
Sbjct: 304 TRLDVYVPPTIEGAGGRPYVVKAVA------GRPVALECVARGHPSPTLSWHHEGLPVAE 357
Query: 511 DGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI-- 568
R +DG+ + + P G+Y C A + G A Q + V+ PP +
Sbjct: 358 SNESRLE----TDGSVL---RLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLV 410
Query: 569 -RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKG 627
+ +T + G+ + C+ G P +I+W ++ + V GT D +
Sbjct: 411 AEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVEL 470
Query: 628 MDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLY-------IPCVV- 679
G + C + + ++ V V+V E P IGQ + P
Sbjct: 471 DHSGLFACQATNEAGTAGAE-VEVSVHGEWAPGVLEVP---IGQYHWGXEHHSSFPAACD 526
Query: 680 --------SSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIA 731
+ P+ W G + +G+ + + LQI V L+ G YTC A
Sbjct: 527 PPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPV-AYSLPPPLQIEKVDLRDEGIYTCAA 585
Query: 732 SNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGN 791
+N A RE L V VPP P N+ + + L C G PPP V W +
Sbjct: 586 TNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVS 645
Query: 792 PQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMI 851
V + GR+ L I D G Y C ASN G+ L V +P I
Sbjct: 646 SWMGVTVSVDGRV-------LRIEQAQLSDAGSYRCVASNVAGS-TELRYGLRVNVPPRI 697
Query: 852 TSHPNTTIAIKGHAK-ELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVS 910
T P+ + + L C A G + W K + P + G V
Sbjct: 698 TLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFP---GGRV-- 752
Query: 911 TLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPD--PPELEIREVKARSMNL 965
L L A DS +SC A+++ GEDR + L V PP EL + V S+ L
Sbjct: 753 -LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVAL 808
Score = 155 bits (392), Expect = 4e-37
Identities = 187/764 (24%), Positives = 304/764 (39%), Gaps = 61/764 (7%)
Query: 95 VTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNS 154
V S + ++PC A G P+ + W P + G+L++ P
Sbjct: 2400 VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE-ILPEGSLRIQPVLAQ---- 2454
Query: 155 FIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNV-AVFKCLIPSSVQ 213
Y C A N+AG R R V P ++ + A+ C S +
Sbjct: 2455 --DAGHYLCLASNSAGSDRQG--RDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPK 2510
Query: 214 EYVSVVSWEKDTVSI---IPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQ 270
+V W KD + + + + + L ++ +D+ + + C+ ++ GE +
Sbjct: 2511 P---LVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDS-AQFECVVSNEV-GEAHR 2565
Query: 271 SNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPA-D 329
+ V PTI D V V L C ++G P P + W K G L A
Sbjct: 2566 LYQVTVHVP------PTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARG 2619
Query: 330 SRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGI 388
S + +G L I +G Y C N+ G A L V V P ++
Sbjct: 2620 SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVA 2679
Query: 389 GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA 448
V+L C +G P TI W + V +S + L L I A +G Y C A
Sbjct: 2680 EEEVLLPCEASGIPRPTITWQKEGLNVAT--GVSTQVLPGGQLRIAHASPEDAGNYLCIA 2737
Query: 449 TRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 508
A +A + ++ P I + + G L C A+G+P P +TW D +P+
Sbjct: 2738 KNSAGSAMGKTRLVVQV-PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPV 2796
Query: 509 VRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI 568
S ++T+ + N+ G +D G Y CTA N VG A + + + P
Sbjct: 2797 ----SGAEGKFTIQPSGELLVKNLEG---QDAGTYTCTAENAVGRARRRVHLTILVLPVF 2849
Query: 569 RAMRNITAVAGRDTL-INCRVIGYPYYSIKWYKDALLLPDNHRQVVFENG--TLKLTDVQ 625
+ ++ D L + C G P I W + + + V ++G TL+ V
Sbjct: 2850 TTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG---VSEQDGGSTLQRAAVS 2906
Query: 626 KGMDEGEYLCSVLIQPQLSISQSVH-VAVKVPPLIQ--PFEFPPASIGQLLYIPCVVSSG 682
+ D G Y+C + ++ +Q+V V VK P++Q F + +G + + CVV
Sbjct: 2907 RE-DSGTYVCWA--ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD 2963
Query: 683 DMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRER 742
+P I W KDG + + GS + + + SL I G Y C+A N +
Sbjct: 2964 PVP-DIHWIKDG-LPLRGSHLRHQLQN--GSLTIRRTERDDAGRYQCLAENEMGVAKKVV 3019
Query: 743 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
L+++ P F V+P + G L C G P P + W A P+ +
Sbjct: 3020 ILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAG--------QPLRASR 3071
Query: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVK 846
R++ LP+ SL + +V D G Y C A N +G+ +++ FL V+
Sbjct: 3072 RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARA-FLVVR 3114
Score = 145 bits (367), Expect = 3e-34
Identities = 164/675 (24%), Positives = 280/675 (41%), Gaps = 57/675 (8%)
Query: 91 SLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPS 150
S +T ++ ++PC A+GSP + W+ D + G +L P +
Sbjct: 2487 SPSNLTLTAHTPALLPCEASGSPKPLVVWWK-------DGQKLDFRLQQGAYRLLPSNAL 2539
Query: 151 AFNS-FIHDNDYF-CTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLI 208
+ D+ F C N G+ + P T+ +DQ + L
Sbjct: 2540 LLTAPGPQDSAQFECVVSNEVGEAHR---LYQVTVHVPPTI-ADDQTDFTVTMMAPVVLT 2595
Query: 209 PSSVQEYVSVVSWEKDTVSIIPEHRFF-ITYHGGLYISDVQKEDALSTYRCITKHKYSGE 267
S VSW K + + ++ G L I A Y C ++ +G
Sbjct: 2596 CHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHA-GRYTCSARNS-AGV 2653
Query: 268 TRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLP 327
+ + + + +P+++ +EV LPC ASG P P I W K+G +
Sbjct: 2654 AHKHVFLTVQASPVVKPLPSVVRAVAEEEVL------LPCEASGIPRPTITWQKEGLNV- 2706
Query: 328 ADSRWTKRITG--LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLK 385
A T+ + G L I+ ED+G Y+C N+ GSA L+V P + L
Sbjct: 2707 ATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLS 2766
Query: 386 TGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 445
T GS L C GSPE I W ++ + V E S E LL+ + + +G Y
Sbjct: 2767 TTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE-LLVKNLEGQDAGTYT 2825
Query: 446 CFATR---KAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
C A +A+ I+ L P + ++ + G++ L CAA+G+P P + W
Sbjct: 2826 CTAENAVGRARRRVHLTILVL----PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 2881
Query: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562
++D P+ S + G+T+ V+ D G Y C A N VG + + ++V
Sbjct: 2882 VNDRPVTEGVSEQ------DGGSTLQRAAVSR---EDSGTYVCWAENRVGRTQAVSFVHV 2932
Query: 563 RGPPSIR--AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLK 620
+ P ++ A + G ++C V G P I W KD L L +H + +NG+L
Sbjct: 2933 KEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLT 2992
Query: 621 LTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAV-KVPPL--IQPFEFPPASIGQLLYIPC 677
+ ++ D G Y C L + ++ +++ V + V + P+ ++P + S G + + C
Sbjct: 2993 IRRTERD-DAGRYQC--LAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRS-GDDVALRC 3048
Query: 678 VVSSGDMPIRITWRKDGQVIISGSGV-TIESKEFMSSLQISSVSLKHNGNYTCIASNAAA 736
++G+ I W + GQ + + + T+ SL + +V G Y C+A N
Sbjct: 3049 -QATGEPTPTIEWLQAGQPLRASRRLRTLPD----GSLWLENVETGDAGTYDCVAHNLLG 3103
Query: 737 TVSRERQLIVRVPPR 751
+ + L+VR P+
Sbjct: 3104 SATARAFLVVRGEPQ 3118
Score = 119 bits (298), Expect = 3e-26
Identities = 127/512 (24%), Positives = 207/512 (40%), Gaps = 46/512 (8%)
Query: 464 EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSD 523
EDG VS + G+ +L C A G P P + W D + + + +
Sbjct: 21 EDGRKANVSGMA------GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGW 74
Query: 524 GTTISH------MNVTGPQIRDG--GVYRCTARNLVGSAEYQARINVRGPPSIR---AMR 572
G H ++ P+I++G G+Y C A N G+A+ + V PPS+ A +
Sbjct: 75 GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQ 134
Query: 573 NITAVAGRDTLINCRVIGYPYYSIKWYKDAL-LLPDN-HRQVVFENGTLKLTDVQKGMDE 630
+ +AG D + C G P ++W KD +LP H QV + L++T G DE
Sbjct: 135 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG-DE 193
Query: 631 GEYLCSVLIQPQLSISQSVHVAVKVPPLIQPF-EFPPASIGQLLYIPCVVSSGDMPI-RI 688
G Y C V P ++ + V PP I E ++ + + + + +P I
Sbjct: 194 GRYQC-VAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI 252
Query: 689 TWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV 748
TW KDG ++ + + V LQ+ G YTC ASNA + +L V V
Sbjct: 253 TWFKDGALLPTSTKVVYTRGG--RQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV 310
Query: 749 PPRFVV---QPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQ 805
PP +P + G+ L C G+P P + W H + PV + +
Sbjct: 311 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHH--------EGLPVAESNESR 362
Query: 806 ILPNSSLL-IRHVLEEDIGYYLCQASNGVGTDISK-SMFLTVKIPAMITSHPNTTIAIKG 863
+ + S+L + E G Y C AS+ G + + S+ + V ++ I G
Sbjct: 363 LETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVG 422
Query: 864 HAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSV 923
EL C A G I+W + + + +A++ +TL + + S
Sbjct: 423 QPLELPCQASGSPVPTIQWLQNGR--PAEELAGVQVASQG------TTLHIDHVELDHSG 474
Query: 924 FFSCHAINSYGEDRGLIQLTVQEPPDPPELEI 955
F+C A N G ++++V P LE+
Sbjct: 475 LFACQATNEAGTAGAEVEVSVHGEWAPGVLEV 506
Score = 104 bits (260), Expect = 8e-22
Identities = 91/356 (25%), Positives = 145/356 (40%), Gaps = 26/356 (7%)
Query: 219 VSWEKDTVSIIPEHRFFITYHGG--LYISDVQKEDALSTYRCITKHKYSGETRQSNGARL 276
V W KD ++P G L I+ D Y+C+ +S +Q+ +L
Sbjct: 158 VEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDE-GRYQCVA---FSPAGQQARDFQL 213
Query: 277 SVTDPAESIPTILDGFHSQEV--WAGHTVELPCTASGYPIPAIRWLKDGRPLPADSR--W 332
V P PTI + EV H V+L C A G P P I W KDG LP ++ +
Sbjct: 214 RVHAP----PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVY 269
Query: 333 TKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLT---PKKLKTGIG 389
T+ L + ++ D+G Y C+ +N G+AE L V P + P +K G
Sbjct: 270 TRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAG 329
Query: 390 STVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFAT 449
V L C G P T+ W+ + L + + S L + S ++ SG Y C A+
Sbjct: 330 RPVALECVARGHPSPTLSWH-HEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVAS 388
Query: 450 RKA-QTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 508
A + +++ + + G+ L C A G+P PT+ W + P
Sbjct: 389 SPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP- 447
Query: 509 VRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG 564
S GTT +++ ++ G++ C A N G+A + ++V G
Sbjct: 448 ---AEELAGVQVASQGTT---LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 497
Score = 98.2 bits (243), Expect = 7e-20
Identities = 91/335 (27%), Positives = 136/335 (40%), Gaps = 20/335 (5%)
Query: 629 DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRI 688
DEG Y C+ S + V + V VPP I+P A + ++SG P +
Sbjct: 577 DEGIYTCAATNLAGES-KREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDV 635
Query: 689 TWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV 748
+W K Q + S GVT+ + L+I L G+Y C+ASN A + L V V
Sbjct: 636 SWFKGHQPVSSWMGVTVSVDGRV--LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV 693
Query: 749 PPRFVVQPNNQDGIYGKAGV-LNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQIL 807
PPR + P+ + V L C+ G P P +MW GNP P +Q+
Sbjct: 694 PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK---DGNPVSPAGTP---GLQVF 747
Query: 808 PNSSLL-IRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAK 866
P +L + D G Y C A + VG D + + L V +P I + +
Sbjct: 748 PGGRVLTLASARASDSGRYSCVAVSAVGED-RQDVVLQVHMPPSILGEELNVSVVANESV 806
Query: 867 ELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFS 926
L C + P ++ W K ++P R + A K + L++ AD D+ ++
Sbjct: 807 ALECQSHAMPPPVLSWWKDGRPLEP-RPGVHLSADK-------ALLQVDRADVWDAGHYT 858
Query: 927 CHAINSYGEDRGLIQLTVQEPPDPPELEIREVKAR 961
C A+N G L V P P E + R
Sbjct: 859 CEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVR 893
Score = 96.3 bits (238), Expect = 3e-19
Identities = 110/423 (26%), Positives = 168/423 (39%), Gaps = 56/423 (13%)
Query: 565 PPSIRA---MRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLL---------------- 605
PPSIR N++ +AG+ + C G+P I W KDA L+
Sbjct: 16 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 75
Query: 606 -PDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEF 664
HR ++ E +L +Q+G D G Y C Q + + H+ V PP +
Sbjct: 76 QVGGHR-LLDEGQSLHFPRIQEG-DSGLYSCRAENQAG-TAQRDFHLLVLTPPSVLGAGA 132
Query: 665 PPASIGQL---LYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSL 721
+G + + C S P ++ W KD Q ++ G G ++ +E L+I+ +
Sbjct: 133 AQEVLGLAGADVELQCWTSGVPTP-QVEWTKDRQPVLPG-GPHLQVQEDGQVLRITGSHV 190
Query: 722 KHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDG----IYGKAGVLNCSVDGYP 777
G Y C+A + A +R+ QL V PP + +N+ G + L C G P
Sbjct: 191 GDEGRYQCVAFSPAGQQARDFQLRVHAPP--TIWGSNETGEVAVMEDHLVQLLCEARGVP 248
Query: 778 PPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDI 837
P + W G+ P V G Q L + D G Y C+ASN VG
Sbjct: 249 TPNITW-FKDGALLPTSTKVVYTRGGRQ------LQLGRAQSSDAGVYTCKASNAVGA-A 300
Query: 838 SKSMFLTVKIPAMIT---SHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRV 894
K+ L V +P I P A+ G L C ARG + W +
Sbjct: 301 EKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPV----- 355
Query: 895 MRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELE 954
A + + + S L+L+ S +SC A + GE ++Q +V E PP+L
Sbjct: 356 ---AESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGE--AVLQYSV-EVQVPPQLL 409
Query: 955 IRE 957
+ E
Sbjct: 410 VAE 412
Score = 93.2 bits (230), Expect = 2e-18
Identities = 204/868 (23%), Positives = 309/868 (35%), Gaps = 168/868 (19%)
Query: 670 GQLLYIPCVVSSGDMPIRITWRKDGQVI-----------------ISGSGVTIESKEFMS 712
GQ L + C + +P I W KD Q++ + G + E +
Sbjct: 33 GQSLTLECDANGFPVP-EIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQ---- 87
Query: 713 SLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQD--GIYGKAGVLN 770
SL + +G Y+C A N A T R+ L+V PP + Q+ G+ G L
Sbjct: 88 SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQ 147
Query: 771 CSVDGYPPPKVMWKHAKGSGNPQQYH-PVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQA 829
C G P P+V W + P H V G++ + S HV +E G Y C A
Sbjct: 148 CWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGS-----HVGDE--GRYQCVA 200
Query: 830 SNGVGTDISKSMFLTVKIPAMITSHPNT--TIAIKGHAKELNCTARGERPIIIRWEKGDT 887
+ G ++ L V P I T ++ H +L C ARG I W K
Sbjct: 201 FSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGA 259
Query: 888 VIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEP 947
++ + Y + L+L A D+ ++C A N+ G +L V P
Sbjct: 260 LLPTSTKVVYTRGGRQ--------LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVP 311
Query: 948 PDPPELE--------IREVKARSMNLRWTQRFDGNSIIT----GFDIEYKNKSDSWDFKQ 995
P +E ++ V R + L R + ++ G + N+S
Sbjct: 312 ---PTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGS 368
Query: 996 STRNISPTINQANIVDLHPASV-------YSIRMYSFNKIGRSEPSKELTISTEEAAPDG 1048
R SP + + +S YS+ + ++ +E ++T G
Sbjct: 369 VLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIV------G 422
Query: 1049 PPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDS 1108
P+++ Q S + W LQNG G + S G+ VE
Sbjct: 423 QPLELPCQASGSPVPTIQW------LQNGRPAEELAGVQVASQGTTLHIDHVE------- 469
Query: 1109 EVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEIN-----ATTLEDVPSQP----PENVRA 1159
LD+ FA QA N AGT + E++ A + +VP E+ +
Sbjct: 470 ----LDHSGLFA-----CQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSS 520
Query: 1160 LSITSDVAVI-SWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTR--------E 1210
D V W P+ L ++G+ WGE I E
Sbjct: 521 FPAACDPPVHRGWGAHPKPPL---VEGW------CSPGSLWGEPTGIPVAYSLPPPLQIE 571
Query: 1211 RVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDV-PGPPAGIKAVPSSASSVV- 1268
+V+LR +T A AG+ R L + ++ PGP KAV +AS +
Sbjct: 572 KVDLRDEGIYT-----CAATNLAGESKREVALKVLVPPNIEPGPVN--KAVLENASVTLE 624
Query: 1269 ----------VSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRG 1318
VSW +P T+ G+ E + YR N
Sbjct: 625 CLASGVPPPDVSWFKGHQPVSSWMGVTVSVD----GRVLRIEQAQLSDAGSYRCVASN-- 678
Query: 1319 QQYLLWVAAVTSAGRG---NSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVG 1375
VA T G N ++T+ P+ P V TP VRL CN+ G
Sbjct: 679 ------VAGSTELRYGLRVNVPPRITLPPSLPGPV-------LVNTP----VRLTCNATG 721
Query: 1376 DPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTII 1435
P+P + W KD + P G ++ L L + +A DSG Y+C A + G D
Sbjct: 722 APSPTLMWLKDGNPVS-PAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQD 780
Query: 1436 VNLLVQVPPD--QPRLTVSKTSASSITL 1461
V L V +PP L VS + S+ L
Sbjct: 781 VVLQVHMPPSILGEELNVSVVANESVAL 808
Score = 84.0 bits (206), Expect = 1e-15
Identities = 90/379 (23%), Positives = 146/379 (38%), Gaps = 28/379 (7%)
Query: 88 VNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPF 147
+ + L ++ + +PC A GSP + W G + + +G L +
Sbjct: 2758 IENGLPDLSTTEGSHAFLPCKARGSPEPNITWD-KDGQPVSGAEGKFTIQPSGELLVKNL 2816
Query: 148 SPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCL 207
+ Y CTAENA G+ R + + + +T D+ G+ +C
Sbjct: 2817 EGQDAGT------YTCTAENAVGRARR-RVHLTILVLPVFTTLPGDRSLRLGDRLWLRCA 2869
Query: 208 IPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG--LYISDVQKEDALSTYRCITKHKYS 265
S + W TV+ P GG L + V +ED+ TY C
Sbjct: 2870 ARGSP---TPRIGW---TVNDRPVTEGVSEQDGGSTLQRAAVSREDS-GTYVC------W 2916
Query: 266 GETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP 325
E R +S E+ + F G +++L C G P+P I W+KDG P
Sbjct: 2917 AENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 2976
Query: 326 LPADS-RWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKL 384
L R + LTI +D+G Y C N G A+ IL++ + P+ +
Sbjct: 2977 LRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDM 3036
Query: 385 KTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAY 444
G V L C TG P TI W + + + +R L + +L + + + +G Y
Sbjct: 3037 TVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASR--RLRTLPDGSLWLENVETGDAGTY 3094
Query: 445 QCFATR--KAQTAQDFAII 461
C A + TA+ F ++
Sbjct: 3095 DCVAHNLLGSATARAFLVV 3113
Score = 53.9 bits (128), Expect = 2e-06
Identities = 41/135 (30%), Positives = 62/135 (45%), Gaps = 9/135 (6%)
Query: 1311 RIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLP 1370
RIAH + A SAG ++ ++ P I + ++T LP
Sbjct: 2721 RIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQ----VPPVIENGLPDLSTTEGSHAFLP 2776
Query: 1371 CNSVGDPAPAVKWTKDSEDSAIPVS-MDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTG 1429
C + G P P + W KD + PVS +G I +G LL++ ++ +D+G YTCTA N
Sbjct: 2777 CKARGSPEPNITWDKDGQ----PVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 2832
Query: 1430 GFDTIIVNLLVQVPP 1444
G V+L + V P
Sbjct: 2833 GRARRRVHLTILVLP 2847
Score = 53.5 bits (127), Expect = 2e-06
Identities = 55/213 (25%), Positives = 86/213 (40%), Gaps = 17/213 (7%)
Query: 1252 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR 1311
GPPA +V +A L P + +GV + P +E PE
Sbjct: 2396 GPPAVNVSVNQTA-------LLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRI 2448
Query: 1312 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC 1371
L + + L +A+ ++ + +EP AP+ + T TP + LPC
Sbjct: 2449 QPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS-NLTLTAHTPAL----LPC 2503
Query: 1372 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1431
+ G P P V W KD + + +RL+ +N LLL A +DS + C +N G
Sbjct: 2504 EASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSN-ALLLTAPGPQDSAQFECVVSNEVGE 2562
Query: 1432 DTIIVNLLVQVPP----DQPRLTVSKTSASSIT 1460
+ + V VPP DQ TV+ + +T
Sbjct: 2563 AHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLT 2595
Score = 50.4 bits (119), Expect = 2e-05
Identities = 38/137 (27%), Positives = 60/137 (43%), Gaps = 21/137 (15%)
Query: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
++V LPC + G P P + W K+ + A VS + G L + ED+G Y C
Sbjct: 2681 EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQ----VLPGGQLRIAHASPEDAGNYLCI 2736
Query: 1425 ATNTGGFDTIIVNLLVQVPP----DQPRLTVSKTSASSI----------TLTWIPGDNGG 1470
A N+ G L+VQVPP P L+ ++ S + + +TW D G
Sbjct: 2737 AKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITW---DKDG 2793
Query: 1471 SSIRGFVLQYSVDNSEE 1487
+ G ++++ S E
Sbjct: 2794 QPVSGAEGKFTIQPSGE 2810
Score = 49.7 bits (117), Expect = 3e-05
Identities = 52/217 (23%), Positives = 89/217 (41%), Gaps = 21/217 (9%)
Query: 1325 VAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWT 1384
V A A R + TIE AG P + + G + V L C + G P+P + W
Sbjct: 297 VGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAG-------RPVALECVARGHPSPTLSWH 349
Query: 1385 KDSEDSAIPVSMDGHRLIHTNGTLL-LRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP 1443
+ +PV+ + T+G++L L + SG Y+C A++ G + ++ VQVP
Sbjct: 350 HEG----LPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVP 405
Query: 1444 PDQPRLTVSKTSASSITLTW----IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERS 1499
P+L V++ T+ +P GS + + +EE V ++S +
Sbjct: 406 ---PQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTT 462
Query: 1500 FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHG 1536
+D ++ A N G+ +E HG
Sbjct: 463 LHIDHVELDHSGLFACQATNEAGTAGAE--VEVSVHG 497
Score = 49.3 bits (116), Expect = 4e-05
Identities = 36/126 (28%), Positives = 56/126 (44%), Gaps = 13/126 (10%)
Query: 1321 YLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPA 1380
Y+ W A GR + V ++ A + S+ + P ++L C GDP P
Sbjct: 2913 YVCW--AENRVGRTQAVSFVHVKEAPVLQGEAFSY---LVEPVGGSIQLDCVVRGDPVPD 2967
Query: 1381 VKWTKDSEDSAIPVSMDGHRLIHT--NGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNL 1438
+ W KD + + G L H NG+L +R + +D+G Y C A N G +V L
Sbjct: 2968 IHWIKDG------LPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVIL 3021
Query: 1439 LVQVPP 1444
++Q P
Sbjct: 3022 VLQSAP 3027
Score = 47.4 bits (111), Expect = 2e-04
Identities = 36/121 (29%), Positives = 48/121 (39%), Gaps = 26/121 (21%)
Query: 1367 VRLPCNSVGDPAPAVKWTKDSEDSA----IPVSMDGHRLIHTNGTLLLRAVKAEDSGYYT 1422
V L C + G P P V W K + + + VS+DG L + + D+G Y
Sbjct: 621 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGR-------VLRIEQAQLSDAGSYR 673
Query: 1423 CTATNTGGFDTIIVNLLVQVPP---------------DQPRLTVSKTSASSITLTWIPGD 1467
C A+N G + L V VPP RLT + T A S TL W+
Sbjct: 674 CVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDG 733
Query: 1468 N 1468
N
Sbjct: 734 N 734
Score = 43.9 bits (102), Expect = 0.002
Identities = 24/77 (31%), Positives = 36/77 (46%), Gaps = 5/77 (6%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLL-LRAVKAEDSGYYTCTATN 1427
L C+ +PAP + W +D I + D H G L L+A+ DSG Y+CTA N
Sbjct: 2319 LECSVEAEPAPKITWHRDG----IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARN 2374
Query: 1428 TGGFDTIIVNLLVQVPP 1444
G ++ + + P
Sbjct: 2375 AAGSTSVAFRVEIHTVP 2391
Score = 43.1 bits (100), Expect = 0.003
Identities = 29/85 (34%), Positives = 40/85 (47%), Gaps = 3/85 (3%)
Query: 1360 TTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSG 1419
T M V L C+S G PAP V W+K + + G+R + +G L + +G
Sbjct: 2585 TVTMMAPVVLTCHSTGIPAPTVSWSK--AGAQLGARGSGYR-VSPSGALEIGQALPIHAG 2641
Query: 1420 YYTCTATNTGGFDTIIVNLLVQVPP 1444
YTC+A N+ G V L VQ P
Sbjct: 2642 RYTCSARNSAGVAHKHVFLTVQASP 2666
Score = 41.2 bits (95), Expect = 0.011
Identities = 24/79 (30%), Positives = 37/79 (46%), Gaps = 4/79 (5%)
Query: 1366 DVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTA 1425
DV L C + G+P P ++W + + P+ +G+L L V+ D+G Y C A
Sbjct: 3043 DVALRCQATGEPTPTIEWLQAGQ----PLRASRRLRTLPDGSLWLENVETGDAGTYDCVA 3098
Query: 1426 TNTGGFDTIIVNLLVQVPP 1444
N G T L+V+ P
Sbjct: 3099 HNLLGSATARAFLVVRGEP 3117
Score = 38.1 bits (87), Expect = 0.092
Identities = 48/196 (24%), Positives = 68/196 (34%), Gaps = 31/196 (15%)
Query: 1272 LPPTKPNGVIRKYTIFCSSPGSGQPAP-----------SEYETSPEQLFYRIAHLNRGQQ 1320
LPP+ P V+ + + +G P+P S T Q+F G+
Sbjct: 699 LPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVF------PGGRV 752
Query: 1321 YLLWVAAVTSAGR---------GNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC 1371
L A + +GR G + V ++ P I+ V+ + V L C
Sbjct: 753 LTLASARASDSGRYSCVAVSAVGEDRQDVVLQV--HMPPSILGEELNVSVVANESVALEC 810
Query: 1372 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1431
S P P + W KD G L L + D+G+YTC A N G
Sbjct: 811 QSHAMPPPVLSWWKDGRPLE---PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGH 867
Query: 1432 DTIIVNLLVQVPPDQP 1447
NL V V P P
Sbjct: 868 SEKHYNLNVWVAPVFP 883
Score = 37.7 bits (86), Expect = 0.12
Identities = 23/79 (29%), Positives = 35/79 (44%), Gaps = 10/79 (12%)
Query: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTAT 1426
+ L C++ G P P + W KD + RL N + R ++ D+G YTC A
Sbjct: 2231 MELLCDAQGTPQPNITWHKDGQALT--------RL--ENNSRATRVLRVRDAGLYTCLAE 2280
Query: 1427 NTGGFDTIIVNLLVQVPPD 1445
+ G + VQ PP+
Sbjct: 2281 SPAGAIEKSFRVRVQAPPN 2299
Score = 37.0 bits (84), Expect = 0.20
Identities = 32/118 (27%), Positives = 46/118 (38%), Gaps = 5/118 (4%)
Query: 1408 LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKT--SASSITLTWIP 1465
L + V D G YTC ATN G V L V VPP+ V+K +S+TL +
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 627
Query: 1466 GDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGS 1523
+ F V + W V +S R +++ + + A N GS
Sbjct: 628 SGVPPPDVSWFKGHQPVSS---WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS 682
Score = 35.4 bits (80), Expect = 0.60
Identities = 24/63 (38%), Positives = 27/63 (42%), Gaps = 7/63 (11%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVS-MDGHRLIHTNGTLLLRAVKAEDSGYYTCTATN 1427
L C + G P P + WT + VS DG TL AV EDSG Y C A N
Sbjct: 2866 LRCAARGSPTPRIGWTVNDRPVTEGVSEQDG------GSTLQRAAVSREDSGTYVCWAEN 2919
Query: 1428 TGG 1430
G
Sbjct: 2920 RVG 2922
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 216 bits (549), Expect = 2e-55
Identities = 210/705 (29%), Positives = 301/705 (42%), Gaps = 70/705 (9%)
Query: 158 DNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVS 217
+ Y CTA + AG R+ ++ P V + G AV C + + E
Sbjct: 374 EGTYECTAVSRAGTGRA-KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV---LGEAPY 429
Query: 218 VVSWEKDTVSIIPEHRFFITYHG--GLYISDVQKEDALSTYRCITKHKYSGETRQSNGA- 274
++W +D ++P + L IS + D Y+C+ + +NG
Sbjct: 430 NLTWVRDW-RVLPASTGRVAQLADLSLEISGIIPTDG-GRYQCVASN--------ANGVT 479
Query: 275 RLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTK 334
R SV P + SQ G V++ C+ASGYP P I W ++ + L DSR
Sbjct: 480 RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV 539
Query: 335 RITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVI 393
G L I + ED+G Y C+ TN G+ + T L DP V+ + +G +
Sbjct: 540 DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV 599
Query: 394 LSCALTGSPEFTIRWYR-NTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKA 452
L C +G P + WYR E++L E G S+ L I +AQ+ +G Y C A +
Sbjct: 600 LVCEASGVPPPRVIWYRGGLEMILAPE-----GSSSGKLRIPAAQERDAGTYTCRAVNEL 654
Query: 453 QTAQDFAIIALEDG-TPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWAL-DDEPI-V 509
A A I L G P++ + V G L C A G PPPTVTW D +P+ +
Sbjct: 655 GDAS--AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL 712
Query: 510 RDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG--PPS 567
R G+ R ++ D + +V D Y C ARN+ G + +AR+ V G PP
Sbjct: 713 RLGAGRGSRSRQPDSGVLFFESVAP---EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQ 769
Query: 568 IRAMR-NITAVAGRDTLINCRVI-GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQ 625
I + + + G+ + C V+ G P W KD LP R + +G+L L D
Sbjct: 770 IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHL-DRA 828
Query: 626 KGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPF-------EFPPASIGQLLYIPCV 678
G Y C V S + V + V+VPP I P E PAS +PCV
Sbjct: 829 LQEHAGRYSC-VATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPAS------LPCV 881
Query: 679 VSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATV 738
S P ITW K+ + S SKE +L I+ S + G Y C A+N
Sbjct: 882 ASGVPAP-TITWTKETNALTSRGPHYNVSKE--GTLLIAQPSAQDAGAYVCTATNTVGFS 938
Query: 739 SRERQLIVRVPPRFVVQPNNQDG----IYGKAG---VLNCSVDGYPPPKVMWKHAKGSGN 791
S+E +L V PR + + + KAG L+C G PPP V W
Sbjct: 939 SQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTW-------- 990
Query: 792 PQQYHPV-PLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGT 835
+ PV P+T R +LP+ SL + V D G+Y C ASN G+
Sbjct: 991 TKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGS 1035
Score = 202 bits (514), Expect = 3e-51
Identities = 192/712 (26%), Positives = 295/712 (41%), Gaps = 63/712 (8%)
Query: 255 TYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPI 314
TY C T +G R A++ VTDP P L + V G T L C G
Sbjct: 376 TYEC-TAVSRAGTGRAK--AQIVVTDP----PPQLVPAPNVTVSPGETAVLSCRVLGEAP 428
Query: 315 PAIRWLKDGRPLPADSRWTKRITGLT--ISDLRTEDSGTYICEVTNTFGSAEATGILMVI 372
+ W++D R LPA + ++ L+ IS + D G Y C +N G A+ L+V
Sbjct: 429 YNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR 488
Query: 373 DPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLL 432
+ V++ G V +SC+ +G P I W R ++ + D I + + TL+
Sbjct: 489 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD--AQGTLI 546
Query: 433 ITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKV-VNPGEQFSLMCAA 491
I +G Y C AT + T Q+ + D P VS+ + V V GE+ L+C A
Sbjct: 547 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD--PPSVSAVNAVVLVAVGEEAVLVCEA 604
Query: 492 KGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLV 551
G PPP V W R G +G++ + + Q RD G Y C A N +
Sbjct: 605 SGVPPPRVIW-------YRGG---LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNEL 654
Query: 552 GSAEYQARINVRGPPSIRAM-RNITAVAGRDTLINCRVIGYPYYSIKWYKD-------AL 603
G A + ++ V P + + R++T GR L+ CR G P ++ W + L
Sbjct: 655 GDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRL 714
Query: 604 LLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVL-IQPQLSISQSVHVAVKVPPLIQPF 662
R ++G L V D+ Y+C + ++ + V PP I
Sbjct: 715 GAGRGSRSRQPDSGVLFFESVAPE-DQAPYVCEARNVFGKVQAEARLIVTGHAPPQIAS- 772
Query: 663 EFPPASI--GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVS 720
P + GQ + +PC+V +G W KDG+ + GS +I + SL +
Sbjct: 773 SAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRAD---GSLHLDRAL 829
Query: 721 LKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPK 780
+H G Y+C+A+N A + R+ +L+V+VPPR + G L C G P P
Sbjct: 830 QEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPT 889
Query: 781 VMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKS 840
+ W + + H + +LLI +D G Y+C A+N VG S+
Sbjct: 890 ITWTKETNALTSRGPH-------YNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS-SQE 941
Query: 841 MFLTVKIPAMI----TSHPNTTIAIKGHAKE---LNCTARGERPIIIRWEKGDTVIDPDR 893
M L+V I + + N + + A E L+C A+G P ++ W K + P
Sbjct: 942 MRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPV-PPI 1000
Query: 894 VMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQ 945
RY + +L+L GDS + C A N G L VQ
Sbjct: 1001 TNRYGLLPS-------GSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
Score = 156 bits (395), Expect = 2e-37
Identities = 157/615 (25%), Positives = 258/615 (41%), Gaps = 51/615 (8%)
Query: 348 DSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIR 407
+ GTY C + G+ A ++V DP + + G T +LSC + G + +
Sbjct: 373 EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT 432
Query: 408 WYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGT 467
W R+ VLP + L++ +L I+ + G YQC A+ A ++ L
Sbjct: 433 WVRDWR-VLPASTGRVAQLADLSLEISGIIPTDGGRYQCVAS-NANGVTRASVWLLVREA 490
Query: 468 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTI 527
P++ S + + G + + C+A G P P ++W+ + + + D + + + GT I
Sbjct: 491 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED----SRIHVDAQGTLI 546
Query: 528 SHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVA-GRDTLINC 586
+ G D G Y C A N VG+ + + PPS+ A+ + VA G + ++ C
Sbjct: 547 ----IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 602
Query: 587 RVIGYPYYSIKWYK---DALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL 643
G P + WY+ + +L P+ +G L++ Q+ D G Y C +
Sbjct: 603 EASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQE-RDAGTYTCRA-VNELG 655
Query: 644 SISQSVHVAV-KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRK-DGQV--IIS 699
S + +AV P L + +G+ + C ++G P +TWR+ DGQ +
Sbjct: 656 DASAEIQLAVGHAPQLTELPRDVTVELGRSALLAC-RATGRPPPTVTWRRGDGQPLGLRL 714
Query: 700 GSGVTIESKEFMSS-LQISSVSLKHNGNYTCIASNAAATVSRERQLIV--RVPPRFVVQP 756
G+G S++ S L SV+ + Y C A N V E +LIV PP+
Sbjct: 715 GAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSA 774
Query: 757 NNQDGIYGKAGVLNCSV-DGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIR 815
+ G+ L C V G P P+ W + P+P R I + SL +
Sbjct: 775 PTVRVLEGQPVSLPCIVLAGRPLPERHWL--------KDGRPLPPGSRHSIRADGSLHLD 826
Query: 816 HVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTT--IAIKGHAKELNCTAR 873
L+E G Y C A+N G+ + + L V++P I HP T I +G L C A
Sbjct: 827 RALQEHAGRYSCVATNTAGSQ-HRDVELVVQVPPRI--HPTATHHITNEGVPASLPCVAS 883
Query: 874 GERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSY 933
G I W K +T R Y ++ + TL + D+ + C A N+
Sbjct: 884 GVPAPTITWTK-ETNALTSRGPHYNVSKE-------GTLLIAQPSAQDAGAYVCTATNTV 935
Query: 934 GEDRGLIQLTVQEPP 948
G ++L+V P
Sbjct: 936 GFSSQEMRLSVNTKP 950
Score = 152 bits (383), Expect = 4e-36
Identities = 166/597 (27%), Positives = 248/597 (41%), Gaps = 70/597 (11%)
Query: 97 FSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFI 156
FS V V V C A+G P+ + W + HV A GTL + +P
Sbjct: 502 FSQGVEVKVSCSASGYPTPHISW--SRESQALQEDSRIHVDAQGTLIIQGVAPE------ 553
Query: 157 HDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSM--RGNVAVFKCLIPSSVQE 214
+Y C A N G + V + +P +V + + G AV C S V
Sbjct: 554 DAGNYSCQATNEVG---TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVPP 609
Query: 215 YVSVVSWEKDTVSII--PEHRFFITYHGGLYISDVQKEDALSTYRCITKHKY---SGETR 269
V W + + +I PE + G L I Q+ DA TY C ++ S E +
Sbjct: 610 --PRVIWYRGGLEMILAPEG----SSSGKLRIPAAQERDA-GTYTCRAVNELGDASAEIQ 662
Query: 270 QSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLK-DGRPL-- 326
+ G +T+ + L G + L C A+G P P + W + DG+PL
Sbjct: 663 LAVGHAPQLTELPRDVTVEL----------GRSALLACRATGRPPPTVTWRRGDGQPLGL 712
Query: 327 ----PADSRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVID--PLHVTL 379
SR + +G L + ED Y+CE N FG +A L+V P +
Sbjct: 713 RLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIAS 772
Query: 380 TPKKLKTGIGSTVILSC-ALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQK 438
+ ++ G V L C L G P W ++ + P SIR ++ +L + A +
Sbjct: 773 SAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIR--ADGSLHLDRALQ 830
Query: 439 SHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPT 498
H+G Y C AT A +Q + + PRI + + + N G SL C A G P PT
Sbjct: 831 EHAGRYSCVATNTA-GSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPT 889
Query: 499 VTWALDDEPIVRDGSHRTNQYTMS-DGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQ 557
+TW + + G H Y +S +GT + + P +D G Y CTA N VG + +
Sbjct: 890 ITWTKETNALTSRGPH----YNVSKEGTLL----IAQPSAQDAGAYVCTATNTVGFSSQE 941
Query: 558 ARINVRGPPSI--RAMRN------ITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPD-N 608
R++V P I RN +TA AG + ++C G P + W KD+ +P
Sbjct: 942 MRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT 1001
Query: 609 HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFP 665
+R + +G+L+L VQ G D G Y C+ P S S + V+ QP P
Sbjct: 1002 NRYGLLPSGSLRLAQVQVG-DSGHYECTA-SNPAGSASHRYVLGVQGRTSWQPQSLP 1056
Score = 146 bits (369), Expect = 2e-34
Identities = 145/563 (25%), Positives = 231/563 (41%), Gaps = 36/563 (6%)
Query: 392 VILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRK 451
+++SC++ + F ++ R E L +E + N + I A K+ G Y+C A +
Sbjct: 327 LLVSCSVHSALPFRLQ-LRRGEARLGEER-HFQESGNSSWEILRASKAEEGTYECTAVSR 384
Query: 452 AQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRD 511
A T + A I + D P++V + V+PGE L C G P +TW D +
Sbjct: 385 AGTGRAKAQIVVTDPPPQLVPA-PNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS 443
Query: 512 GSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAM 571
+S + ++G DGG Y+C A N G + VR P +
Sbjct: 444 TGRVAQLADLS-------LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIH 496
Query: 572 RNITAVA-GRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDE 630
+ + G + ++C GYP I W +++ L ++ R V GTL + V D
Sbjct: 497 TSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAP-EDA 555
Query: 631 GEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFE-FPPASIGQLLYIPCVVSSGDMPIRIT 689
G Y C + ++V + PP + ++G+ + C +SG P R+
Sbjct: 556 GNYSCQATNEVGTD-QETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVPPPRVI 613
Query: 690 WRKDG-QVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV 748
W + G ++I++ G + L+I + + G YTC A N S E QL V
Sbjct: 614 WYRGGLEMILAPEGSS------SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGH 667
Query: 749 PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILP 808
P+ P + G++ +L C G PPP V W+ +G G P G P
Sbjct: 668 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWR--RGDGQPLGLRLGAGRGSRSRQP 725
Query: 809 NSSLL-IRHVLEEDIGYYLCQASNGVG-TDISKSMFLTVKIPAMITSHPNTTIAIKGHAK 866
+S +L V ED Y+C+A N G + +T P I S T ++G
Sbjct: 726 DSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPV 785
Query: 867 ELNCTARGERPIIIR-WEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFF 925
L C RP+ R W K + P R++I +L L A + + +
Sbjct: 786 SLPCIVLAGRPLPERHWLKDGRPLPPG--SRHSIRAD-------GSLHLDRALQEHAGRY 836
Query: 926 SCHAINSYGEDRGLIQLTVQEPP 948
SC A N+ G ++L VQ PP
Sbjct: 837 SCVATNTAGSQHRDVELVVQVPP 859
Score = 129 bits (323), Expect = 4e-29
Identities = 160/614 (26%), Positives = 234/614 (38%), Gaps = 63/614 (10%)
Query: 161 YFCTAENAAGKIRSPNIRVKAVFREP--YTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218
Y C A NA G R+ V + RE ++ Q +G C S Y +
Sbjct: 468 YQCVASNANGVTRAS---VWLLVREAPQVSIHTSSQHFSQGVEVKVSC----SASGYPTP 520
Query: 219 -VSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
+SW +++ ++ + R + G L I V EDA Y C ++ + L
Sbjct: 521 HISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDA-GNYSCQATNEVGTDQET---VTLY 576
Query: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPL---PADSRWTK 334
TDP P++ V G L C ASG P P + W + G + P S K
Sbjct: 577 YTDP----PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK 632
Query: 335 RITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVIL 394
L I + D+GTY C N G A A L V +T P+ + +G + +L
Sbjct: 633 ----LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALL 688
Query: 395 SCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNE-----TLLITSAQKSHSGAYQCFAT 449
+C TG P T+ W R L + RG + L S Y C A
Sbjct: 689 ACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEAR 748
Query: 450 RKAQTAQDFA-IIALEDGTPRIVSSFSEKVVNPGEQFSLMCAA-KGAPPPTVTWALDDEP 507
Q A +I P+I SS V G+ SL C G P P W D P
Sbjct: 749 NVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRP 808
Query: 508 IVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS 567
+ H +DG+ +++ G Y C A N GS + V+ PP
Sbjct: 809 LPPGSRHSIR----ADGS----LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPR 860
Query: 568 IR--AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQV-VFENGTLKLTDV 624
I A +IT G + C G P +I W K+ L V + GTL +
Sbjct: 861 IHPTATHHITN-EGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQ- 918
Query: 625 QKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQ---------PFEFPPASIGQLLYI 675
D G Y+C+ S SQ + ++V P I P + A G+ + +
Sbjct: 919 PSAQDAGAYVCTATNTVGFS-SQEMRLSVNTKPRIHMNGSRNANVPLQVT-AKAGEEVTL 976
Query: 676 PCVVSSGDMPIRITWRKDGQVI--ISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASN 733
C + G P +TW KD + + I+ + S SL+++ V + +G+Y C ASN
Sbjct: 977 DCE-AKGSPPPLVTWTKDSRPVPPITNRYGLLPS----GSLRLAQVQVGDSGHYECTASN 1031
Query: 734 AAATVSRERQLIVR 747
A + S L V+
Sbjct: 1032 PAGSASHRYVLGVQ 1045
Score = 118 bits (296), Expect = 5e-26
Identities = 94/390 (24%), Positives = 164/390 (42%), Gaps = 24/390 (6%)
Query: 564 GPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTD 623
G P + I + L++C V + ++ + L + N + ++
Sbjct: 309 GAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILR 368
Query: 624 VQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGD 683
K +EG Y C+ + + +++ V PP + P S G+ + C V G+
Sbjct: 369 ASKA-EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL-GE 426
Query: 684 MPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQ 743
P +TW +D +V+ + +G + + SL+IS + G Y C+ASNA
Sbjct: 427 APYNLTWVRDWRVLPASTGRVAQLADL--SLEISGIIPTDGGRYQCVASNANGVTRASVW 484
Query: 744 LIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGR 803
L+VR P+ + ++Q G ++CS GYP P + W ++ + R
Sbjct: 485 LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWS--------RESQALQEDSR 536
Query: 804 IQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKG 863
I + +L+I+ V ED G Y CQA+N VGTD +++ L P +++ + G
Sbjct: 537 IHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD-QETVTLYYTDPPSVSAVNAVVLVAVG 595
Query: 864 HAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSV 923
L C A G P + W +G + +A + + L++ A D+
Sbjct: 596 EEAVLVCEASGVPPPRVIWYRGG--------LEMILAPEGSSS---GKLRIPAAQERDAG 644
Query: 924 FFSCHAINSYGEDRGLIQLTVQEPPDPPEL 953
++C A+N G+ IQL V P EL
Sbjct: 645 TYTCRAVNELGDASAEIQLAVGHAPQLTEL 674
Score = 59.3 bits (142), Expect = 4e-08
Identities = 33/76 (43%), Positives = 43/76 (56%), Gaps = 3/76 (3%)
Query: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNT 1428
LPC + G PAP + WTK E +A+ S H + GTLL+ A+D+G Y CTATNT
Sbjct: 878 LPCVASGVPAPTITWTK--ETNAL-TSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNT 934
Query: 1429 GGFDTIIVNLLVQVPP 1444
GF + + L V P
Sbjct: 935 VGFSSQEMRLSVNTKP 950
Score = 56.6 bits (135), Expect = 2e-07
Identities = 42/121 (34%), Positives = 54/121 (44%), Gaps = 10/121 (8%)
Query: 1346 GKAPAKIISFGGTVTTPWMKDVRLPCNSV-GDPAPAVKWTKDSEDSAIPVSMDGHRLIHT 1404
G AP +I S TV + V LPC + G P P W KD P+ I
Sbjct: 764 GHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGR----PLPPGSRHSIRA 819
Query: 1405 NGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWI 1464
+G+L L E +G Y+C ATNT G V L+VQVPP + T+ IT +
Sbjct: 820 DGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP-----RIHPTATHHITNEGV 874
Query: 1465 P 1465
P
Sbjct: 875 P 875
Score = 53.9 bits (128), Expect = 2e-06
Identities = 26/79 (32%), Positives = 43/79 (54%), Gaps = 4/79 (5%)
Query: 1366 DVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTA 1425
+V++ C++ G P P + W+++S+ + D + GTL+++ V ED+G Y+C A
Sbjct: 507 EVKVSCSASGYPTPHISWSRESQ----ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQA 562
Query: 1426 TNTGGFDTIIVNLLVQVPP 1444
TN G D V L PP
Sbjct: 563 TNEVGTDQETVTLYYTDPP 581
Score = 52.0 bits (123), Expect = 6e-06
Identities = 29/72 (40%), Positives = 41/72 (56%), Gaps = 3/72 (4%)
Query: 1359 VTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDS 1418
VT ++V L C + G P P V WTKDS +P + + L+ +G+L L V+ DS
Sbjct: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSR--PVPPITNRYGLL-PSGSLRLAQVQVGDS 1022
Query: 1419 GYYTCTATNTGG 1430
G+Y CTA+N G
Sbjct: 1023 GHYECTASNPAG 1034
Score = 39.3 bits (90), Expect = 0.041
Identities = 48/209 (22%), Positives = 74/209 (35%), Gaps = 29/209 (13%)
Query: 1289 SSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKA 1348
S SG P P + Q + ++ Q L + V GN S + T E
Sbjct: 511 SCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQ 570
Query: 1349 ---------PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH 1399
P + + V ++ L C + G P P V W + + + + +G
Sbjct: 571 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMIL--APEGS 628
Query: 1400 RLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP---DQPR-------- 1448
++G L + A + D+G YTC A N G + + L V P + PR
Sbjct: 629 ----SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGR 684
Query: 1449 ---LTVSKTSASSITLTWIPGDNGGSSIR 1474
L T T+TW GD +R
Sbjct: 685 SALLACRATGRPPPTVTWRRGDGQPLGLR 713
Score = 34.3 bits (77), Expect = 1.3
Identities = 30/135 (22%), Positives = 55/135 (40%), Gaps = 7/135 (5%)
Query: 1310 YRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRL 1369
+ I ++ ++ AV+ AG G + ++ + P +++ +P V L
Sbjct: 364 WEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDP---PPQLVPAPNVTVSPGETAV-L 419
Query: 1370 PCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTG 1429
C +G+ + W +D +P S G + +L + + D G Y C A+N
Sbjct: 420 SCRVLGEAPYNLTWVRDWR--VLPAST-GRVAQLADLSLEISGIIPTDGGRYQCVASNAN 476
Query: 1430 GFDTIIVNLLVQVPP 1444
G V LLV+ P
Sbjct: 477 GVTRASVWLLVREAP 491
Score = 32.7 bits (73), Expect = 3.9
Identities = 25/101 (24%), Positives = 42/101 (41%), Gaps = 7/101 (6%)
Query: 1334 GNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIP 1393
G++S ++ + G AP ++ VT + L C + G P P V W + + +
Sbjct: 655 GDASAEIQLA-VGHAP-QLTELPRDVTVELGRSALLACRATGRPPPTVTWRR-GDGQPLG 711
Query: 1394 VSMDGHRLIHT----NGTLLLRAVKAEDSGYYTCTATNTGG 1430
+ + R + +G L +V ED Y C A N G
Sbjct: 712 LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFG 752
Score = 32.0 bits (71), Expect = 6.6
Identities = 23/70 (32%), Positives = 33/70 (47%), Gaps = 15/70 (21%)
Query: 1409 LLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQ----PRLTVSKTSASSIT---- 1460
+LRA KAE+ G Y CTA + G ++V PP Q P +TVS + ++
Sbjct: 366 ILRASKAEE-GTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 424
Query: 1461 ------LTWI 1464
LTW+
Sbjct: 425 GEAPYNLTWV 434
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 215 bits (547), Expect = 4e-55
Identities = 236/956 (24%), Positives = 385/956 (40%), Gaps = 86/956 (8%)
Query: 357 TNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN-TELV 415
++ GS G + PL V + + V+L+C SP T RW N TE+
Sbjct: 26 SSALGSQTTFGPVFEDQPLSVLFPEESTE----EQVLLACRARASPPATYRWKMNGTEMK 81
Query: 416 LPDEAISIRGLSNETLLITSAQKSH-SGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSF 474
L E S L L+I + K+ +G YQC A+ T I L G + S
Sbjct: 82 L--EPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAI-LRFGFLQEFSKE 138
Query: 475 SEKVVNPGEQFSLMCAAKGA---PPPTVTWALDDEP--IVRDGSHRTNQYTMSDGTTISH 529
V E + +M P + W L++ P I DG H +Q T +
Sbjct: 139 ERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQ-------TTGN 191
Query: 530 MNVTGPQIRDGGVYRCTARNLVGSAEYQ-----ARINVRGP------PSIRAM--RNITA 576
+ + D G Y C A + + + A++N+ PSI+A A
Sbjct: 192 LYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYA 251
Query: 577 VAGRDTLINCRVIGYPYYSIKWYK-DALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC 635
+ G+ + C G P IKW K D L P Q TL++ V DEG Y C
Sbjct: 252 LVGQQVTLECFAFGNPVPRIKWRKVDGSLSP----QWTTAEPTLQIPSVSFE-DEGTYEC 306
Query: 636 SVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQ 695
Q + P ++ A IG L C + P + W ++G+
Sbjct: 307 EAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPT-VRWLRNGE 365
Query: 696 VIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVR-VPPRFVV 754
+ S + V + L+ S +SL+ +G Y C+A N T+ +L V+ + P F +
Sbjct: 366 PLASQNRVEV----LAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRL 421
Query: 755 QPNNQDGIYGKAG--VLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSL 812
P + + G ++ C P V+W +KG+ + + R+ + P+ +L
Sbjct: 422 NPVRRLIPAARGGEILIPCQPRAAPKAVVLW--SKGT------EILVNSSRVTVTPDGTL 473
Query: 813 LIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTA 872
+IR++ D G Y C A N +G S + L+V+ IT P++ G L C A
Sbjct: 474 IIRNISRSDEGKYTCFAENFMGKANSTGI-LSVRDATKITLAPSSADINLGDNLTLQCHA 532
Query: 873 RGE--RPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAI 930
+ + W D ID D+ + T N E + L + A ++C A
Sbjct: 533 SHDPTMDLTFTWTLDDFPIDFDKPGGHYRRT--NVKETIGDLTILNAQLRHGGKYTCMAQ 590
Query: 931 NSYGEDRGLIQLTVQEPPDPPE-LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNK-S 988
+ V+ PP PP + +R++ ++ L W++ FD +S I + ++ + +
Sbjct: 591 TVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPA 650
Query: 989 DSW-DFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELT-ISTEEAAP 1046
W + + NI A ++ L P Y R+ + N +G EPS + I T EAAP
Sbjct: 651 GKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAP 710
Query: 1047 DGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENS---------PGSNGQY 1097
P ++ + V W +E QNG GY + +R PG++ QY
Sbjct: 711 SVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQY 770
Query: 1098 SIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENV 1157
VY+ ++++ + + V ++++NR G GP S + E+ P P V
Sbjct: 771 F-----------VYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKV 819
Query: 1158 RALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGM 1217
A ++S ++W EP + +NG+L GY + +W + + G+
Sbjct: 820 WAKGVSSSEMNVTW-EPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGL 878
Query: 1218 EKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLP 1273
T Y V V AY +AG G S T + P P G + S+SS+ + W P
Sbjct: 879 HPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDP 934
Score = 156 bits (395), Expect = 2e-37
Identities = 226/1004 (22%), Positives = 383/1004 (38%), Gaps = 127/1004 (12%)
Query: 303 VELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG---LTISDLRTEDSGTYICEVTNT 359
V L C A P RW +G + + ++ G + ++ + +D+G Y C +N
Sbjct: 57 VLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNP 116
Query: 360 FGSAEATGILMVIDPLHVTLTPKK--LKTGIGSTVILSCALTGS-PEFTIRWYRNT-ELV 415
G+ + ++ L ++ +K G V+L C P + RW N
Sbjct: 117 VGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNF 176
Query: 416 LPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAI-------IALEDG-- 466
+P + + L I S G Y C AT + +A ED
Sbjct: 177 IPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRL 236
Query: 467 -TPRIVSSF-SEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDG 524
P I + F +E G+Q +L C A G P P + W D + + Q+T ++
Sbjct: 237 FAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSL-------SPQWTTAEP 289
Query: 525 TTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS-IRAMRNITAVAGRDTL 583
T + + D G Y C A N G Q RI V+ P ++ + + A G +
Sbjct: 290 T----LQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLR 345
Query: 584 INCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL 643
C G P +++W ++ L +R V G L+ + + D G Y C V
Sbjct: 346 WGCAAAGKPRPTVRWLRNGEPLASQNRVEVLA-GDLRFSKLSLE-DSGMYQC-VAENKHG 402
Query: 644 SISQSVHVAVKVPPLIQPFEFPP------ASIGQLLYIPCVVSSGDMPIRITWRKDGQVI 697
+I S +AV+ L F P A+ G + IPC + + + W K +++
Sbjct: 403 TIYASAELAVQA--LAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAV-VLWSKGTEIL 459
Query: 698 ISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPN 757
++ S VT+ +L I ++S G YTC A N + L VR + + P+
Sbjct: 460 VNSSRVTVTPD---GTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPS 516
Query: 758 NQDGIYGKAGVLNCSVDGYPPPKVMWKHA---------KGSGNPQQYHPVPLTGRIQILP 808
+ D G L C P + + K G+ ++ + G + IL
Sbjct: 517 SADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTIL- 575
Query: 809 NSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIP------AMITSHPNTTIAIK 862
+ +RH G Y C A V + SK + V+ P ++ +TTI +
Sbjct: 576 --NAQLRHG-----GKYTCMAQTVVDS-ASKEATVLVRGPPGPPGGVVVRDIGDTTIQLS 627
Query: 863 ------GHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKP 916
H+ T + P +W++ +R A + E L L P
Sbjct: 628 WSRGFDNHSPIAKYTLQARTPPAGKWKQ----------VRTNPANIEGNAETAQVLGLTP 677
Query: 917 ADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSM----NLRWTQRFD 972
+ F A N G P P +IR +A L
Sbjct: 678 WMDYE---FRVIASNILGTGE----------PSGPSSKIRTREAAPSVAPSGLSGGGGAP 724
Query: 973 GNSII--TGFDIEYKNKSDSWDFKQSTRNISPTINQANIV-------------DLHPASV 1017
G I+ T EY+N D + + S R T Q V + P +
Sbjct: 725 GELIVNWTPMSREYQN-GDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTP 783
Query: 1018 YSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNG 1077
+ +++ S+N+ G S + + E P P V + V+S + VTW+ P ++ NG
Sbjct: 784 FEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWE-PVQQDMNG 842
Query: 1078 VIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPS 1137
++ GY+I Y + + + + ++ G + L +Y V V+A+NRAGTGP+
Sbjct: 843 ILLGYEIRYWK---AGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPA 899
Query: 1138 SSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDG 1197
S NATT++ P +PP N+ + + +S I W + GY++++ + D
Sbjct: 900 SPSANATTMKPPPRRPPGNI-SWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQN---DL 955
Query: 1198 EWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSV 1241
++ T + +E+ E + VQ+ GDG+ + V
Sbjct: 956 HLTPTLHL-TGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEV 998
Score = 143 bits (361), Expect = 2e-33
Identities = 136/489 (27%), Positives = 208/489 (42%), Gaps = 54/489 (11%)
Query: 102 GVVVPC-PAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDND 160
GV++PC P A P + RW L + RH + T LY +A + +
Sbjct: 150 GVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDG-RHFVSQTTGNLYIARTNASDL----GN 204
Query: 161 YFCTAENAAGKIRSPNIRVKAVFRE--PYTVRVEDQRSMRGNV-AVFKCLIPSSVQEYVS 217
Y C A + + K+VF + + ED R ++ A F + V + V+
Sbjct: 205 YSCLATSHM------DFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVT 258
Query: 218 V-----------VSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSG 266
+ + W K S+ P+ + T L I V ED TY C ++
Sbjct: 259 LECFAFGNPVPRIKWRKVDGSLSPQ---WTTAEPTLQIPSVSFEDE-GTYECEAENSKGR 314
Query: 267 ETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPL 326
+T Q R+ V E + I D E G + C A+G P P +RWL++G PL
Sbjct: 315 DTVQG---RIIVQAQPEWLKVISD----TEADIGSNLRWGCAAAGKPRPTVRWLRNGEPL 367
Query: 327 PADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMV---IDPLHVTLTPKK 383
+ +R L S L EDSG Y C N G+ A+ L V + +
Sbjct: 368 ASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRL 427
Query: 384 LKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGA 443
+ G +++ C +P+ + W + TE+++ +++ + TL+I + +S G
Sbjct: 428 IPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTV--TPDGTLIIRNISRSDEGK 485
Query: 444 YQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPP--TVTW 501
Y CFA A I+++ D T +I + S +N G+ +L C A P T TW
Sbjct: 486 YTCFAENFMGKANSTGILSVRDAT-KITLAPSSADINLGDNLTLQCHASHDPTMDLTFTW 544
Query: 502 ALDDEPIVRD--GSH--RTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQ 557
LDD PI D G H RTN TI + + Q+R GG Y C A+ +V SA +
Sbjct: 545 TLDDFPIDFDKPGGHYRRTNV-----KETIGDLTILNAQLRHGGKYTCMAQTVVDSASKE 599
Query: 558 ARINVRGPP 566
A + VRGPP
Sbjct: 600 ATVLVRGPP 608
Score = 140 bits (352), Expect = 2e-32
Identities = 207/916 (22%), Positives = 339/916 (37%), Gaps = 120/916 (13%)
Query: 240 GGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWA 299
G L I + K Y+C+ + T S A L E D + E W
Sbjct: 93 GNLVIMNPTKAQDAGVYQCLASNPVG--TVVSREAILRFGFLQEFSKEERDPVKAHEGWG 150
Query: 300 GHTVELPCTASG-YPIPAIRWLKDGRP--LPADSR-WTKRITG-LTISDLRTEDSGTYIC 354
V LPC YP + RWL + P +P D R + + TG L I+ D G Y C
Sbjct: 151 ---VMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSC 207
Query: 355 EVTNTFG---------------SAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALT 399
T+ +AE T + P P + +G V L C
Sbjct: 208 LATSHMDFSTKSVFSKFAQLNLAAEDTRLFA---PSIKARFPAETYALVGQQVTLECFAF 264
Query: 400 GSPEFTIRWYRNTELVLPDEAISIRGLSNE-TLLITSAQKSHSGAYQCFA--TRKAQTAQ 456
G+P I+W + D ++S + + E TL I S G Y+C A ++ T Q
Sbjct: 265 GNPVPRIKWRK------VDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQ 318
Query: 457 DFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRT 516
I+ + P + S+ + G CAA G P PTV W + EP+
Sbjct: 319 GRIIVQAQ---PEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQ----- 370
Query: 517 NQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG-PPSIR---AMR 572
N+ + G + + + D G+Y+C A N G+ A + V+ P R R
Sbjct: 371 NRVEVLAGD----LRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRR 426
Query: 573 NITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632
I A G + LI C+ P + W K +L ++ R V +GTL + ++ + DEG+
Sbjct: 427 LIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRS-DEGK 485
Query: 633 YLC---SVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGD-MPIRI 688
Y C + + + + SV A K+ + ++G L + C S M +
Sbjct: 486 YTCFAENFMGKANSTGILSVRDATKITLAPSSADI---NLGDNLTLQCHASHDPTMDLTF 542
Query: 689 TWRKDGQVII----SGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQL 744
TW D I G KE + L I + L+H G YTC+A + S+E +
Sbjct: 543 TWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATV 602
Query: 745 IVRVPP------------RFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNP 792
+VR PP +Q + G + + ++ PP WK + NP
Sbjct: 603 LVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVR--TNP 660
Query: 793 QQYHPVPLTGRI-QILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMI 851
T ++ + P R + ASN +GT ++
Sbjct: 661 ANIEGNAETAQVLGLTPWMDYEFRVI-----------ASNILGTGEPSGPSSKIR----- 704
Query: 852 TSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVST 911
T ++A G L+ +I+ W Y ++ + G T
Sbjct: 705 TREAAPSVAPSG----LSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQT 760
Query: 912 LKLKPADRGDSVFFSCHA---------INSYG------EDRGLIQLTVQEPP--DPPELE 954
++ AD V+ + I SY E + + +E P P ++
Sbjct: 761 ARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVW 820
Query: 955 IREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLH 1013
+ V + MN+ W + D N I+ G++I Y D R + A + LH
Sbjct: 821 AKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRT-AGLDTSARVSGLH 879
Query: 1014 PASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKE 1073
P + Y + + ++N+ G S +T + P PP +++ +S S+ + W
Sbjct: 880 PNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNIS-WTFSSSSLSIKWDPVVPF 938
Query: 1074 LQNGVIRGYQIGYREN 1089
+ GY++ Y+ +
Sbjct: 939 RNESAVTGYKMLYQND 954
Score = 119 bits (297), Expect = 4e-26
Identities = 160/634 (25%), Positives = 250/634 (39%), Gaps = 63/634 (9%)
Query: 79 EDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHA 138
ED S+ F +S ++ V++ C A SP A RW + G ++ P RH
Sbjct: 40 EDQPLSVLFPEESTEEQ-------VLLACRARASPPATYRWKM-NGTEMKLEPGSRHQLV 91
Query: 139 NGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMR 198
G L + +P+ Y C A N G + S ++ F + ++ D
Sbjct: 92 GGNLVI--MNPTKAQD---AGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAH 146
Query: 199 GNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIP-EHRFFITY-HGGLYISDVQKEDALSTY 256
V P + +S + + IP + R F++ G LYI+ D L Y
Sbjct: 147 EGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASD-LGNY 205
Query: 257 RCI-TKH-KYSGETRQSNGARLSVT--DPAESIPTILDGFHSQE-VWAGHTVELPCTASG 311
C+ T H +S ++ S A+L++ D P+I F ++ G V L C A G
Sbjct: 206 SCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFG 265
Query: 312 YPIPAIRWLK-DGRPLPADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILM 370
P+P I+W K DG P +WT L I + ED GTY CE N+ G G ++
Sbjct: 266 NPVPRIKWRKVDGSLSP---QWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRII 322
Query: 371 VIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNET 430
V + IGS + CA G P T+RW RN E + + + L+ +
Sbjct: 323 VQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEV--LAGD- 379
Query: 431 LLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNP--GEQFSLM 488
L + SG YQC A K T A +A++ P + +++ G + +
Sbjct: 380 LRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIP 439
Query: 489 CAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTAR 548
C + AP V W+ E +V +++ T++ T+ N++ D G Y C A
Sbjct: 440 CQPRAAPKAVVLWSKGTEILV-----NSSRVTVTPDGTLIIRNISR---SDEGKYTCFAE 491
Query: 549 NLVGSAEYQARINVRGPPSIR-AMRNITAVAGRDTLINCRVIGYPYYSI--KWYKDALLL 605
N +G A ++VR I A + G + + C P + W D +
Sbjct: 492 NFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPI 551
Query: 606 ----PDNH--RQVVFEN-GTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPL 658
P H R V E G L + + Q G+Y C S S+ V V+ PP
Sbjct: 552 DFDKPGGHYRRTNVKETIGDLTILNAQL-RHGGKYTCMAQTVVD-SASKEATVLVRGPP- 608
Query: 659 IQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRK 692
PP + V GD I+++W +
Sbjct: 609 -----GPPGGV-------VVRDIGDTTIQLSWSR 630
Score = 55.1 bits (131), Expect = 7e-07
Identities = 82/349 (23%), Positives = 136/349 (38%), Gaps = 60/349 (17%)
Query: 1312 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGK---APAKI-ISFGGTVTTPWMKDV 1367
I +++R + A G+ NS+ +++ A K AP+ I+ G +T
Sbjct: 475 IRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLT------- 527
Query: 1368 RLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTN-----GTLLLRAVKAEDSGYYT 1422
L C++ DP + +T +D I G TN G L + + G YT
Sbjct: 528 -LQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYT 586
Query: 1423 CTATNTGGFDTIIVNLLVQVPPDQPR-LTVSKTSASSITLTWIPGDNGGSSIRGFVLQYS 1481
C A + +LV+ PP P + V ++I L+W G + S I + LQ
Sbjct: 587 CMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQAR 646
Query: 1482 VDNSEEWKDV-----FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHG 1536
+ +WK V I + + ++ L Y+ ++ A N +G+G
Sbjct: 647 TPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTG------------ 694
Query: 1537 REPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIV------------------LEYR 1578
EPS + + A L G GG P IV L +R
Sbjct: 695 -EPSGPSSKIRTREAAPSVAPSGLSG--GGGAPGELIVNWTPMSREYQNGDGFGYLLSFR 751
Query: 1579 PKGTWAWQGLR---ANSSGEVFLTE-LREATWYELRMRACNSAGCGNET 1623
+G+ WQ R A++ V+ E +R T +E+++R+ N G G E+
Sbjct: 752 RQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPES 800
Score = 46.6 bits (109), Expect = 3e-04
Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 7/99 (7%)
Query: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
+ V L C + G+P P +KW K + S P + TL + +V ED G Y C
Sbjct: 255 QQVTLECFAFGNPVPRIKWRK-VDGSLSP------QWTTAEPTLQIPSVSFEDEGTYECE 307
Query: 1425 ATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTW 1463
A N+ G DT+ ++VQ P+ ++ + L W
Sbjct: 308 AENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRW 346
Score = 41.2 bits (95), Expect = 0.011
Identities = 69/282 (24%), Positives = 108/282 (38%), Gaps = 49/282 (17%)
Query: 1366 DVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT-NGTLLLRAVKAEDSGYYTCT 1424
++ +PC P V W+K +E + ++ R+ T +GTL++R + D G YTC
Sbjct: 435 EILIPCQPRAAPKAVVLWSKGTE-----ILVNSSRVTVTPDGTLIIRNISRSDEGKYTCF 489
Query: 1425 ATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDN 1484
A N G L V+ D ++T++ +SA I L GDN LQ +
Sbjct: 490 AENFMGKANSTGILSVR---DATKITLAPSSA-DINL----GDN-------LTLQCHASH 534
Query: 1485 SEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRI------------------ 1526
+ D+ + + F +D K G Y+ + K ++G I
Sbjct: 535 -DPTMDLTFTWTLDDFPIDFDKPGGHYR-RTNVKETIGDLTILNAQLRHGGKYTCMAQTV 592
Query: 1527 --SEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWA 1584
S EA R P + I T +L+ + PI L+ R
Sbjct: 593 VDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGK 652
Query: 1585 WQGLR---ANSSGEVFLTELREAT-W--YELRMRACNSAGCG 1620
W+ +R AN G ++ T W YE R+ A N G G
Sbjct: 653 WKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTG 694
Score = 38.9 bits (89), Expect = 0.054
Identities = 26/81 (32%), Positives = 36/81 (44%), Gaps = 6/81 (7%)
Query: 1366 DVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTA 1425
++R C + G P P V+W ++ E A +R+ G L + EDSG Y C A
Sbjct: 343 NLRWGCAAAGKPRPTVRWLRNGEPLA-----SQNRVEVLAGDLRFSKLSLEDSGMYQCVA 397
Query: 1426 TNTGGFDTIIVNLLVQ-VPPD 1445
N G L VQ + PD
Sbjct: 398 ENKHGTIYASAELAVQALAPD 418
Score = 36.2 bits (82), Expect = 0.35
Identities = 24/69 (34%), Positives = 32/69 (46%), Gaps = 4/69 (5%)
Query: 1367 VRLPCNSVGD-PAPAVKWTKDSEDSAIPVSMDG-HRLIHTNGTLLLRAVKAEDSGYYTCT 1424
V LPCN P + +W + + IP DG H + T G L + A D G Y+C
Sbjct: 151 VMLPCNPPAHYPGLSYRWLLNEFPNFIPT--DGRHFVSQTTGNLYIARTNASDLGNYSCL 208
Query: 1425 ATNTGGFDT 1433
AT+ F T
Sbjct: 209 ATSHMDFST 217
Score = 34.3 bits (77), Expect = 1.3
Identities = 30/118 (25%), Positives = 50/118 (42%), Gaps = 9/118 (7%)
Query: 1317 RGQQYLLWVAAV----TSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCN 1372
R + +LL VAAV +SA + T P + + F T + V L C
Sbjct: 6 RRKPHLLLVAAVALVSSSAWSSALGSQTTFGPVFEDQPLSVLFPEESTE---EQVLLACR 62
Query: 1373 SVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
+ P +W + + + H+L+ N +++ KA+D+G Y C A+N G
Sbjct: 63 ARASPPATYRWKMNGTEMKLEPG-SRHQLVGGN-LVIMNPTKAQDAGVYQCLASNPVG 118
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 214 bits (546), Expect = 5e-55
Identities = 245/979 (25%), Positives = 418/979 (42%), Gaps = 84/979 (8%)
Query: 680 SSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS-LQISSVSLKHN-GNYTCIASNAAAT 737
++G+ RITW K G+ + S IE + S L+I + ++ + Y C A+N+
Sbjct: 56 ATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGE 115
Query: 738 VSRERQLIV----RVPPRFV-VQPNNQDGIYGKA--GVLNCSVDGYPPPKVMWKHAKGSG 790
++ +L V ++PP F + Q + KA + C+ G P P++ W
Sbjct: 116 INTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFK----- 170
Query: 791 NPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAM 850
+ P GRI+ L + +L I E D G Y C A+N GT S L V++ +
Sbjct: 171 DFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRV 230
Query: 851 ---ITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDE 907
+ P++ + G + L C A G ++W G + + M
Sbjct: 231 APRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGR-------- 282
Query: 908 VVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP-ELEIREVKARSMNLR 966
+ L+L R S ++C AI+S G Q+TV+ P PP +L + E A S+ L
Sbjct: 283 --NVLELSNVVR--SANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLT 338
Query: 967 WTQRFDGNSI-ITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSF 1025
W GNS +T + I+Y+ F Q ++ T + +I L P S Y+ R+ +
Sbjct: 339 WDS---GNSEPVTYYGIQYRAAGTEGPF-QEVDGVATT--RYSIGGLSPFSEYAFRVLAV 392
Query: 1026 NKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIG 1085
N IGR PS+ + T E AP PP V + +++ ++ V W+ P++ NG++RGY++
Sbjct: 393 NSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEP--NGLVRGYRVY 450
Query: 1086 YRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATT 1145
Y +P S + T + T+ +L Y + V AF G GP S I T
Sbjct: 451 Y---TPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKT 507
Query: 1146 LEDVPSQPPENVRALSITSDVAV-ISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQN 1204
+ VP+QP + + SD + +SW PP+ + Y +++W+ + + ++
Sbjct: 508 QQGVPAQPADF--QAEVESDTRIQLSWLLPPQERIIM----YELVYWAAEDEDQQHKVTF 561
Query: 1205 ITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPG-PPAGIKAVPSS 1263
T+ +E ++ T Y Q+ A + G GV + + +T + P PP + V
Sbjct: 562 DPTSSYTLE--DLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMG 619
Query: 1264 ASSVVVSWLPPTKP--NGVIRKYTI-FCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQ 1320
+++V VSW+PP NGVI +Y++ + + G + S E + + L + +
Sbjct: 620 STTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTE 679
Query: 1321 YLLWVAAVTSAGRGNSSEKVTI---EPAGKAPAKIISFGGTVTTPWMKDVRLPCNSV--- 1374
Y +WV A T G G S V + E P + + +T +LP S
Sbjct: 680 YRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHG 739
Query: 1375 ---GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1431
G V+ ++ E +P+ D ++ + + E + T A T G
Sbjct: 740 QIRGYQVTYVR-LENGEPRGLPIIQDV--MLAEAQETTISGLTPETTYSVTVAAYTTKGD 796
Query: 1432 DTIIVNLLVQVP---PDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEW 1488
+V P +P + +S T+ ++ L W P + G+ LQY +
Sbjct: 797 GARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARP 856
Query: 1489 KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPS-FSKDQHL 1547
+ ++ F + L GT Y +LAAKN G G E E +T PS F ++ H+
Sbjct: 857 NTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFE-KEIRTPEDLPSGFPQNLHV 915
Query: 1548 FTHINSTHARLNLQGWN------NGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTEL 1601
T + ++ L W+ G I+ V+ Q + ++ LT L
Sbjct: 916 -TGLTTSTTEL---AWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDT--RFTLTGL 969
Query: 1602 REATWYELRMRACNSAGCG 1620
+ T Y++++RA S G G
Sbjct: 970 KPDTTYDIKVRAWTSKGSG 988
Score = 213 bits (542), Expect = 2e-54
Identities = 265/1053 (25%), Positives = 436/1053 (41%), Gaps = 150/1053 (14%)
Query: 565 PPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVV-FENGT---LK 620
P I+ + T ++G C+ G P I W K + +V+ F++G L+
Sbjct: 33 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLR 92
Query: 621 LTDVQKGMDEGEYLCSV---LIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIP- 676
+ ++ DE Y C+ L + S SV ++PP FP +G L +
Sbjct: 93 IQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPP-----GFPSIDMGPQLKVVE 147
Query: 677 -------CVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTC 729
+ G+ I+W KD + + + +LQI S G Y C
Sbjct: 148 KARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYEC 207
Query: 730 IASNAAAT-VSRERQLIVRV---PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKH 785
+A+N+A T S L VRV PRF + P++Q+ + G + L C G P P V W
Sbjct: 208 VATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMM 267
Query: 786 AKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTV 845
+ PV GR + L + +V+ Y C A + +G I + +TV
Sbjct: 268 GAEELTKEDEMPV---GR------NVLELSNVVRS--ANYTCVAISSLGM-IEATAQVTV 315
Query: 846 KIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRY-AIATKDN 904
K A+ +L T + + W+ G++ ++Y A T+
Sbjct: 316 K-------------ALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGP 362
Query: 905 GDEVVSTLKLKPADRGDSVF----FSCHAINSYGE----DRGLIQLTVQEPPDPPE-LEI 955
EV + + G S F F A+NS G + + Q P PP ++
Sbjct: 363 FQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQA 422
Query: 956 REVKARSMNLRWTQRFDGNSIITGFDIEYKNKS----DSWDFKQSTRNISPTINQANIVD 1011
R + A +M ++W + N ++ G+ + Y S ++W + + T+
Sbjct: 423 RMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGS----- 477
Query: 1012 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK 1071
L P YS+R+ +F +G PS + + T++ P P D + + IQ++W P
Sbjct: 478 LLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQPADFQAEVESDTRIQLSWLLPP 536
Query: 1072 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGD-SEVYTLDNLKKFAQYGVVVQAFN 1130
+E I Y++ Y + K T D + YTL++LK Y + A +
Sbjct: 537 QER----IIMYELVYWAAEDEDQ------QHKVTFDPTSSYTLEDLKPDTLYRFQLAARS 586
Query: 1131 RAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIF 1190
G G + I A T + PS PP+ V +S+ S +SW PP + NGV+ Y V +
Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAY 646
Query: 1191 WSLYVDGE---WGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTK 1247
+ VDGE + I+ +L G+EK+T Y V V A+T G G SS + ++T
Sbjct: 647 EA--VDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTD 704
Query: 1248 EDVP-GPPAGIKAVPSSASSVVVSW-LP-PTKPNGVIRKYTIFCSSPGSGQPA--PSEYE 1302
EDVP GPP ++ P ++++V V W LP P+K +G IR Y + +G+P P +
Sbjct: 705 EDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQD 764
Query: 1303 TS-PEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTT 1361
E I+ L Y + VAA T+ G G S+ + G P +
Sbjct: 765 VMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGR---------- 814
Query: 1362 PWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKA------ 1415
P M N+ ++W E +P + G+RL + RA +A
Sbjct: 815 PTMMISTTAMNTA-----LLQWHPPKE---LPGELLGYRLQYC------RADEARPNTID 860
Query: 1416 --EDSGYYTCTATNTGGFDTIIVNLL--------------VQVPPDQP-----RLTVSKT 1454
+D ++T T + G T I L ++ P D P L V+
Sbjct: 861 FGKDDQHFTVTGLHKG--TTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGL 918
Query: 1455 SASSITLTWIP---GDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWY 1511
+ S+ L W P + G I V+ +++ +E +++ +++ F L LK T Y
Sbjct: 919 TTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNI---TTDTRFTLTGLKPDTTY 975
Query: 1512 KVKLAAKNSVGSGRISEIIEAKTHGREPSFSKD 1544
+K+ A S GSG +S I+++T E F+K+
Sbjct: 976 DIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKN 1008
Score = 121 bits (303), Expect = 8e-27
Identities = 190/830 (22%), Positives = 312/830 (37%), Gaps = 135/830 (16%)
Query: 855 PNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKL 914
P + G C A GE I W K + R + + D+G S L++
Sbjct: 39 PEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR---FEVIEFDDG--AGSVLRI 93
Query: 915 KPAD-RGDSVFFSCHAINSYGEDRGLIQLTVQE----PPDPPELE-------IREVKARS 962
+P + D + C A NS GE +L+V E PP P ++ + + + +
Sbjct: 94 QPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTAT 153
Query: 963 M----------NLRWTQRF------DGNSIIT-----GFDIEYKNKSDSWDFKQSTRNIS 1001
M + W + F N I IE +SD ++ N +
Sbjct: 154 MLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSA 213
Query: 1002 PTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQ 1061
T A PA++Y ++ R P + S++E P G +++T V +
Sbjct: 214 GTRYSA------PANLYV-------RVRRVAPRFSIPPSSQEVMPGGS-VNLTCVAVGAP 259
Query: 1062 SIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQ 1121
V W +EL E G N V L N+ + A
Sbjct: 260 MPYVKWMMGAEELTKE---------DEMPVGRN---------------VLELSNVVRSAN 295
Query: 1122 YGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISW----SEPPRS 1177
Y V A + G +++++ L +PP ++ T+ ++W SEP
Sbjct: 296 YTCV--AISSLGMIEATAQVTVKALP----KPPIDLVVTETTATSVTLTWDSGNSEP--- 346
Query: 1178 TLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGV 1237
+ Y + + + +G + E+ + TTR + G+ F+ Y+ +VLA G G
Sbjct: 347 -----VTYYGIQYRAAGTEGPFQEVDGVATTR--YSIGGLSPFSEYAFRVLAVNSIGRGP 399
Query: 1238 RSSVLYIQTKEDVPG-PPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQP 1296
S + +T E P PP ++A SAS+++V W PP +PNG++R Y ++ + P
Sbjct: 400 PSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPP 459
Query: 1297 APSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFG 1356
+ L + L G Y L V A T+ G G S + ++ PA+ F
Sbjct: 460 NAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQ 519
Query: 1357 GTVTTPWMKDVRLPCNSVGDPA------PAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLL 1410
V + D R+ + + P V W + ED V+ D + L
Sbjct: 520 AEVES----DTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFD------PTSSYTL 569
Query: 1411 RAVKAEDSGYYTCTATN---TGGFDTIIVNLLVQVPPDQPRLTVSKTSASSIT--LTWIP 1465
+K + + A + G F I Q P P V S S T ++W+P
Sbjct: 570 EDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVP 629
Query: 1466 GDNGGSSIRGFVLQYS-----VDNSEEWKDVF--ISSSERSFKLDSLKCGTWYKVKLAAK 1518
S G + QYS VD + + V IS S+ L L+ T Y+V + A
Sbjct: 630 PP--ADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAH 687
Query: 1519 NSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINST----HARLNLQGWNNG---GCPIT 1571
VG G S + +T PS + +NST + +L + +G G +T
Sbjct: 688 TDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVT 747
Query: 1572 AIVLEY-RPKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCG 1620
+ LE P+G Q + + E ++ L T Y + + A + G G
Sbjct: 748 YVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDG 797
Score = 115 bits (287), Expect = 6e-25
Identities = 117/477 (24%), Positives = 188/477 (39%), Gaps = 44/477 (9%)
Query: 943 TVQEPPDPPELEIREVKARSMNLR--WTQ--RFDGNSIITGFDIEYKNKSDSWDFKQSTR 998
T Q P P ++ V S +R W N +IT + + Y+ +
Sbjct: 601 TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660
Query: 999 NISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPV 1058
IS + ++V L + Y + + + +G S + + T+E P GPP V ++P+
Sbjct: 661 GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL 720
Query: 1059 TSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKK 1118
S ++ V WK P Q+G IRGYQ+ Y G I++ +++ T+ L
Sbjct: 721 NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTP 780
Query: 1119 FAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRST 1178
Y V V A+ G G S TT VP +P + ++ + A++ W PP+
Sbjct: 781 ETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAM--NTALLQW-HPPKE- 836
Query: 1179 LNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVR 1238
L G L GYR+ + D + + + G+ K T Y ++ A +AG G
Sbjct: 837 LPGELLGYRLQY--CRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLG-E 893
Query: 1239 SSVLYIQTKEDVP-GPPAGIKAVPSSASSVVVSWLPP--TKPNGVIRKYTIFCSSPGSGQ 1295
I+T ED+P G P + + S+ ++W PP + NG I YT+ S Q
Sbjct: 894 EFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ 953
Query: 1296 PAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIE--PAGKAPAKII 1353
E + + + L Y + V A TS G G S + P + AK
Sbjct: 954 ----ELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNF 1009
Query: 1354 SFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIP---------VSMDGHRL 1401
+ T + +P DS SA+P V +DGH +
Sbjct: 1010 RVAAAMKTSVLLSWEVP---------------DSYKSAVPFKILYNGQSVEVDGHSM 1051
Score = 87.4 bits (215), Expect = 1e-16
Identities = 74/301 (24%), Positives = 119/301 (39%), Gaps = 28/301 (9%)
Query: 283 ESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG---- 338
+S P + Q +G C A+G P P I W+K G+ + +
Sbjct: 30 DSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGS 89
Query: 339 -LTISDLRTE-DSGTYICEVTNTFGSAEATGILMVIDPLH-------VTLTPKKLKTGIG 389
L I LR + D Y C TN+ G + L V++ + + P+
Sbjct: 90 VLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKA 149
Query: 390 STVILSCALTGSPEFTIRWYRNTELVLPDEAIS-IRGLSNETLLITSAQKSHSGAYQCFA 448
T + CA G+P+ I W+++ V P + I+ L + L I S+++S G Y+C A
Sbjct: 150 RTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVA 209
Query: 449 TRKAQT---AQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDD 505
T A T A + + PR S + V PG +L C A GAP P V W +
Sbjct: 210 TNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGA 269
Query: 506 EPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGP 565
E + ++ + + + N Y C A + +G E A++ V+
Sbjct: 270 EELTKEDEMPVGRNVLELSNVVRSAN-----------YTCVAISSLGMIEATAQVTVKAL 318
Query: 566 P 566
P
Sbjct: 319 P 319
Score = 68.6 bits (166), Expect = 6e-11
Identities = 101/439 (23%), Positives = 162/439 (36%), Gaps = 61/439 (13%)
Query: 185 EPYTVRV-EDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG-- 241
+P ++V EDQ + G VA F C + E ++W K + + I + G
Sbjct: 32 KPVFIKVPEDQTGLSGGVASFVC---QATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAG 88
Query: 242 --LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAE---SIPTILDGFHSQE 296
L I ++ + + Y C T GE S A+LSV + + P+I G +
Sbjct: 89 SVLRIQPLRVQRDEAIYEC-TATNSLGEINTS--AKLSVLEEEQLPPGFPSIDMGPQLKV 145
Query: 297 VWAGHTVELPCTASGYPIPAIRWLKDGRPL-PADSRW---TKRITGLTISDLRTEDSGTY 352
V T + C A G P P I W KD P+ PA S R L I D G Y
Sbjct: 146 VEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKY 205
Query: 353 ICEVTNTFGSAEATGILMVIDPLHV----TLTPKKLKTGIGSTVILSCALTGSPEFTIRW 408
C TN+ G+ + + + V ++ P + G +V L+C G+P ++W
Sbjct: 206 ECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKW 265
Query: 409 YRNT-ELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGT 467
EL DE R + + ++ SA Y C A + A + ++
Sbjct: 266 MMGAEELTKEDEMPVGRNVLELSNVVRSAN------YTCVAISSLGMIEATAQVTVK--- 316
Query: 468 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTW-ALDDEPIVRDG-----SHRTNQYTM 521
P L+ A T+TW + + EP+ G + +
Sbjct: 317 -----------ALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQE 365
Query: 522 SDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS--IRAMRNITAVAG 579
DG + ++ G +R A N +G RGPPS +RA A +
Sbjct: 366 VDGVATTRYSIGGLSPFSEYAFRVLAVNSIG----------RGPPSEAVRARTGEQAPSS 415
Query: 580 RDTLINCRVIGYPYYSIKW 598
+ R++ ++W
Sbjct: 416 PPRRVQARMLSASTMLVQW 434
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 214 bits (544), Expect = 9e-55
Identities = 266/1062 (25%), Positives = 439/1062 (41%), Gaps = 159/1062 (14%)
Query: 565 PPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVV-FENGT---LK 620
P I+ + T ++G C+ G P I W K + +V+ F++G L+
Sbjct: 33 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLR 92
Query: 621 LTDVQKGMDEGEYLCSV---LIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIP- 676
+ ++ DE Y C+ L + S SV ++PP FP +G L +
Sbjct: 93 IQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPP-----GFPSIDMGPQLKVVE 147
Query: 677 -------CVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTC 729
+ G+ I+W KD + + + +LQI S G Y C
Sbjct: 148 KARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYEC 207
Query: 730 IASNAAAT-VSRERQLIVRV---PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKH 785
+A+N+A T S L VRV PRF + P++Q+ + G + L C G P P V W
Sbjct: 208 VATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMM 267
Query: 786 AKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTV 845
+ PV GR + L + +V+ Y C A + +G I + +TV
Sbjct: 268 GAEELTKEDEMPV---GR------NVLELSNVVRS--ANYTCVAISSLGM-IEATAQVTV 315
Query: 846 KIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRY-AIATKDN 904
K A+ +L T + + W+ G++ ++Y A T+
Sbjct: 316 K-------------ALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGP 362
Query: 905 GDEVVSTLKLKPADRGDSVF----FSCHAINSYGE----DRGLIQLTVQEPPDPPE-LEI 955
EV + + G S F F A+NS G + + Q P PP ++
Sbjct: 363 FQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQA 422
Query: 956 REVKARSMNLRWTQRFDGNSIITGFDIEYKNKS----DSWDFKQSTRNISPTINQANIVD 1011
R + A +M ++W + N ++ G+ + Y S ++W + + T+
Sbjct: 423 RMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGS----- 477
Query: 1012 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK 1071
L P YS+R+ +F +G PS + + T++ P P D + + IQ++W P
Sbjct: 478 LLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQPADFQAEVESDTRIQLSWLLPP 536
Query: 1072 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGD-SEVYTLDNLKKFAQYGVVVQAFN 1130
+E I Y++ Y + K T D + YTL++LK Y + A +
Sbjct: 537 QER----IIMYELVYWAAEDEDQ------QHKVTFDPTSSYTLEDLKPDTLYRFQLAARS 586
Query: 1131 RAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIF 1190
G G + I A T + PS PP+ V +S+ S +SW PP + NGV+ Y V +
Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAY 646
Query: 1191 WSLYVDGE---WGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTK 1247
+ VDGE + I+ +L G+EK+T Y V V A+T G G SS + ++T
Sbjct: 647 EA--VDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTD 704
Query: 1248 EDVP-GPPAGIKAVPSSASSVVVSW-LP-PTKPNGVIRKYTIFCSSPGSGQPAP------ 1298
EDVP GPP ++ P ++++V V W LP P+K +G IR Y + +G+P
Sbjct: 705 EDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQD 764
Query: 1299 ---SEYETSPEQ---LFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKI 1352
+E + PE+ I+ L Y + VAA T+ G G S+ + G P +
Sbjct: 765 VMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGR- 823
Query: 1353 ISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRA 1412
P M N+ ++W E +P + G+RL + RA
Sbjct: 824 ---------PTMMISTTAMNTA-----LLQWHPPKE---LPGELLGYRLQYC------RA 860
Query: 1413 VKA--------EDSGYYTCTATNTGGFDTIIVNLL--------------VQVPPDQP--- 1447
+A +D ++T T + G T I L ++ P D P
Sbjct: 861 DEARPNTIDFGKDDQHFTVTGLHKG--TTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGF 918
Query: 1448 --RLTVSKTSASSITLTWIP---GDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKL 1502
L V+ + S+ L W P + G I V+ +++ +E +++ +++ F L
Sbjct: 919 PQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNI---TTDTRFTL 975
Query: 1503 DSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKD 1544
LK T Y +K+ A S GSG +S I+++T E F+K+
Sbjct: 976 TGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKN 1017
Score = 211 bits (537), Expect = 6e-54
Identities = 247/995 (24%), Positives = 419/995 (42%), Gaps = 107/995 (10%)
Query: 680 SSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS-LQISSVSLKHN-GNYTCIASNAAAT 737
++G+ RITW K G+ + S IE + S L+I + ++ + Y C A+N+
Sbjct: 56 ATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGE 115
Query: 738 VSRERQLIV----RVPPRFV-VQPNNQDGIYGKA--GVLNCSVDGYPPPKVMWKHAKGSG 790
++ +L V ++PP F + Q + KA + C+ G P P++ W
Sbjct: 116 INTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFK----- 170
Query: 791 NPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAM 850
+ P GRI+ L + +L I E D G Y C A+N GT S L V++ +
Sbjct: 171 DFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRV 230
Query: 851 ---ITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDE 907
+ P++ + G + L C A G ++W G + + M
Sbjct: 231 APRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGR-------- 282
Query: 908 VVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP-ELEIREVKARSMNLR 966
+ L+L R S ++C AI+S G Q+TV+ P PP +L + E A S+ L
Sbjct: 283 --NVLELSNVVR--SANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLT 338
Query: 967 WTQRFDGNSI-ITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSF 1025
W GNS +T + I+Y+ F Q ++ T + +I L P S Y+ R+ +
Sbjct: 339 WDS---GNSEPVTYYGIQYRAAGTEGPF-QEVDGVATT--RYSIGGLSPFSEYAFRVLAV 392
Query: 1026 NKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIG 1085
N IGR PS+ + T E AP PP V + +++ ++ V W+ P++ NG++RGY++
Sbjct: 393 NSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEP--NGLVRGYRVY 450
Query: 1086 YRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATT 1145
Y +P S + T + T+ +L Y + V AF G GP S I T
Sbjct: 451 Y---TPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKT 507
Query: 1146 LEDVPSQPPENVRALSITSDVAV-ISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQN 1204
+ VP+QP + + SD + +SW PP+ + Y +++W+ + + ++
Sbjct: 508 QQGVPAQPADF--QAEVESDTRIQLSWLLPPQERIIM----YELVYWAAEDEDQQHKVTF 561
Query: 1205 ITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPG-PPAGIKAVPSS 1263
T+ +E ++ T Y Q+ A + G GV + + +T + P PP + V
Sbjct: 562 DPTSSYTLE--DLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMG 619
Query: 1264 ASSVVVSWLPPTKP--NGVIRKYTI-FCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQ 1320
+++V VSW+PP NGVI +Y++ + + G + S E + + L + +
Sbjct: 620 STTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTE 679
Query: 1321 YLLWVAAVTSAGRGNSSEKVTI---EPAGKAPAKIISFGGTVTTPWMKDVRLPCNSV--- 1374
Y +WV A T G G S V + E P + + +T +LP S
Sbjct: 680 YRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHG 739
Query: 1375 ---GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAV-KAEDSGYYTCTATNTGG 1430
G V+ ++ E +P+ D +L A + E+S Y T +
Sbjct: 740 QIRGYQVTYVR-LENGEPRGLPIIQD---------VMLAEAQWRPEESEDYETTISGLTP 789
Query: 1431 FDTIIVNLLVQVP------------------PDQPRLTVSKTSASSITLTWIPGDNGGSS 1472
T V + P +P + +S T+ ++ L W P
Sbjct: 790 ETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGE 849
Query: 1473 IRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEA 1532
+ G+ LQY + + ++ F + L GT Y +LAAKN G G E E
Sbjct: 850 LLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFE-KEI 908
Query: 1533 KTHGREPS-FSKDQHLFTHINSTHARLNLQGWN------NGGCPITAIVLEYRPKGTWAW 1585
+T PS F ++ H+ T + ++ L W+ G I+ V+
Sbjct: 909 RTPEDLPSGFPQNLHV-TGLTTSTTEL---AWDPPVLAERNGRIISYTVVFRDINSQQEL 964
Query: 1586 QGLRANSSGEVFLTELREATWYELRMRACNSAGCG 1620
Q + ++ LT L+ T Y++++RA S G G
Sbjct: 965 QNITTDT--RFTLTGLKPDTTYDIKVRAWTSKGSG 997
Score = 115 bits (289), Expect = 3e-25
Identities = 174/756 (23%), Positives = 282/756 (37%), Gaps = 127/756 (16%)
Query: 855 PNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKL 914
P + G C A GE I W K + R + + D+G S L++
Sbjct: 39 PEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR---FEVIEFDDG--AGSVLRI 93
Query: 915 KPAD-RGDSVFFSCHAINSYGEDRGLIQLTVQE----PPDPPELE-------IREVKARS 962
+P + D + C A NS GE +L+V E PP P ++ + + + +
Sbjct: 94 QPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTAT 153
Query: 963 M----------NLRWTQRF------DGNSIIT-----GFDIEYKNKSDSWDFKQSTRNIS 1001
M + W + F N I IE +SD ++ N +
Sbjct: 154 MLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSA 213
Query: 1002 PTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQ 1061
T A PA++Y ++ R P + S++E P G +++T V +
Sbjct: 214 GTRYSA------PANLYV-------RVRRVAPRFSIPPSSQEVMPGGS-VNLTCVAVGAP 259
Query: 1062 SIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQ 1121
V W +EL E G N V L N+ + A
Sbjct: 260 MPYVKWMMGAEELTKE---------DEMPVGRN---------------VLELSNVVRSAN 295
Query: 1122 YGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISW----SEPPRS 1177
Y V A + G +++++ L +PP ++ T+ ++W SEP
Sbjct: 296 YTCV--AISSLGMIEATAQVTVKALP----KPPIDLVVTETTATSVTLTWDSGNSEP--- 346
Query: 1178 TLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGV 1237
+ Y + + + +G + E+ + TTR + G+ F+ Y+ +VLA G G
Sbjct: 347 -----VTYYGIQYRAAGTEGPFQEVDGVATTR--YSIGGLSPFSEYAFRVLAVNSIGRGP 399
Query: 1238 RSSVLYIQTKEDVPG-PPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQP 1296
S + +T E P PP ++A SAS+++V W PP +PNG++R Y ++ + P
Sbjct: 400 PSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPP 459
Query: 1297 APSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFG 1356
+ L + L G Y L V A T+ G G S + ++ PA+ F
Sbjct: 460 NAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQ 519
Query: 1357 GTVTTPWMKDVRLPCNSVGDPA------PAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLL 1410
V + D R+ + + P V W + ED V+ D + L
Sbjct: 520 AEVES----DTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFD------PTSSYTL 569
Query: 1411 RAVKAEDSGYYTCTATN---TGGFDTIIVNLLVQVPPDQPRLTVSKTSASSIT--LTWIP 1465
+K + + A + G F I Q P P V S S T ++W+P
Sbjct: 570 EDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVP 629
Query: 1466 GDNGGSSIRGFVLQYS-----VDNSEEWKDVF--ISSSERSFKLDSLKCGTWYKVKLAAK 1518
S G + QYS VD + + V IS S+ L L+ T Y+V + A
Sbjct: 630 PP--ADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAH 687
Query: 1519 NSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINST 1554
VG G S + +T PS + +NST
Sbjct: 688 TDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNST 723
Score = 109 bits (272), Expect = 3e-23
Identities = 122/486 (25%), Positives = 191/486 (39%), Gaps = 53/486 (10%)
Query: 943 TVQEPPDPPELEIREVKARSMNLR--WTQ--RFDGNSIITGFDIEYKNKSDSWDFKQSTR 998
T Q P P ++ V S +R W N +IT + + Y+ +
Sbjct: 601 TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660
Query: 999 NISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPV 1058
IS + ++V L + Y + + + +G S + + T+E P GPP V ++P+
Sbjct: 661 GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL 720
Query: 1059 TSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVE--MKATG-----DSEVY 1111
S ++ V WK P Q+G IRGYQ+ Y G I++ M A +SE Y
Sbjct: 721 NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDY 780
Query: 1112 --TLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVI 1169
T+ L Y V V A+ G G S TT VP +P + ++ + A++
Sbjct: 781 ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAM--NTALL 838
Query: 1170 SWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLA 1229
W PP+ L G L GYR+ + D + + + G+ K T Y ++ A
Sbjct: 839 QW-HPPKE-LPGELLGYRLQY--CRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAA 894
Query: 1230 YTQAGDGVRSSVLYIQTKEDVP-GPPAGIKAVPSSASSVVVSWLPP--TKPNGVIRKYTI 1286
+AG G I+T ED+P G P + + S+ ++W PP + NG I YT+
Sbjct: 895 KNRAGLG-EEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTV 953
Query: 1287 FCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIE--P 1344
S Q E + + + L Y + V A TS G G S + P
Sbjct: 954 VFRDINSQQ----ELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMP 1009
Query: 1345 AGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIP---------VS 1395
+ AK + T + +P DS SA+P V
Sbjct: 1010 VEQVFAKNFRVAAAMKTSVLLSWEVP---------------DSYKSAVPFKILYNGQSVE 1054
Query: 1396 MDGHRL 1401
+DGH +
Sbjct: 1055 VDGHSM 1060
Score = 87.4 bits (215), Expect = 1e-16
Identities = 74/301 (24%), Positives = 119/301 (39%), Gaps = 28/301 (9%)
Query: 283 ESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG---- 338
+S P + Q +G C A+G P P I W+K G+ + +
Sbjct: 30 DSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGS 89
Query: 339 -LTISDLRTE-DSGTYICEVTNTFGSAEATGILMVIDPLH-------VTLTPKKLKTGIG 389
L I LR + D Y C TN+ G + L V++ + + P+
Sbjct: 90 VLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKA 149
Query: 390 STVILSCALTGSPEFTIRWYRNTELVLPDEAIS-IRGLSNETLLITSAQKSHSGAYQCFA 448
T + CA G+P+ I W+++ V P + I+ L + L I S+++S G Y+C A
Sbjct: 150 RTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVA 209
Query: 449 TRKAQT---AQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDD 505
T A T A + + PR S + V PG +L C A GAP P V W +
Sbjct: 210 TNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGA 269
Query: 506 EPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGP 565
E + ++ + + + N Y C A + +G E A++ V+
Sbjct: 270 EELTKEDEMPVGRNVLELSNVVRSAN-----------YTCVAISSLGMIEATAQVTVKAL 318
Query: 566 P 566
P
Sbjct: 319 P 319
Score = 68.6 bits (166), Expect = 6e-11
Identities = 101/439 (23%), Positives = 162/439 (36%), Gaps = 61/439 (13%)
Query: 185 EPYTVRV-EDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG-- 241
+P ++V EDQ + G VA F C + E ++W K + + I + G
Sbjct: 32 KPVFIKVPEDQTGLSGGVASFVC---QATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAG 88
Query: 242 --LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAE---SIPTILDGFHSQE 296
L I ++ + + Y C T GE S A+LSV + + P+I G +
Sbjct: 89 SVLRIQPLRVQRDEAIYEC-TATNSLGEINTS--AKLSVLEEEQLPPGFPSIDMGPQLKV 145
Query: 297 VWAGHTVELPCTASGYPIPAIRWLKDGRPL-PADSRW---TKRITGLTISDLRTEDSGTY 352
V T + C A G P P I W KD P+ PA S R L I D G Y
Sbjct: 146 VEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKY 205
Query: 353 ICEVTNTFGSAEATGILMVIDPLHV----TLTPKKLKTGIGSTVILSCALTGSPEFTIRW 408
C TN+ G+ + + + V ++ P + G +V L+C G+P ++W
Sbjct: 206 ECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKW 265
Query: 409 YRNT-ELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGT 467
EL DE R + + ++ SA Y C A + A + ++
Sbjct: 266 MMGAEELTKEDEMPVGRNVLELSNVVRSAN------YTCVAISSLGMIEATAQVTVK--- 316
Query: 468 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTW-ALDDEPIVRDG-----SHRTNQYTM 521
P L+ A T+TW + + EP+ G + +
Sbjct: 317 -----------ALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQE 365
Query: 522 SDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS--IRAMRNITAVAG 579
DG + ++ G +R A N +G RGPPS +RA A +
Sbjct: 366 VDGVATTRYSIGGLSPFSEYAFRVLAVNSIG----------RGPPSEAVRARTGEQAPSS 415
Query: 580 RDTLINCRVIGYPYYSIKW 598
+ R++ ++W
Sbjct: 416 PPRRVQARMLSASTMLVQW 434
Score = 58.5 bits (140), Expect = 7e-08
Identities = 108/470 (22%), Positives = 178/470 (37%), Gaps = 75/470 (15%)
Query: 1209 RERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVV 1268
R +EL + + NY+ ++ G+ + + K +P PP + ++A+SV
Sbjct: 282 RNVLELSNVVRSANYTCVAISSL----GMIEATAQVTVKA-LPKPPIDLVVTETTATSVT 336
Query: 1269 VSWLPPTKPNGVIRKYTIF-CSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAA 1327
++W +G T + +G P + Y I L+ +Y V A
Sbjct: 337 LTW-----DSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLA 391
Query: 1328 VTSAGRGNSSEKVTIEPAGKAP--------AKIISFGGTVTTPW---------------- 1363
V S GRG SE V +AP A+++S T+ W
Sbjct: 392 VNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLS-ASTMLVQWEPPEEPNGLVRGYRVY 450
Query: 1364 -MKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYT 1422
D R P N+ W K + D+ + ++ G L +L + A A G +
Sbjct: 451 YTPDSRRPPNA---------WHKHNTDAGLLTTV-GSLLPGITYSLRVLAFTAVGDGPPS 500
Query: 1423 CTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSV 1482
TI V VP S + I L+W+ + V +
Sbjct: 501 ---------PTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAE 551
Query: 1483 DNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFS 1542
D ++ K F +S S+ L+ LK T Y+ +LAA++ +G G + IEA+T PS
Sbjct: 552 DEDQQHKVTFDPTS--SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAP 609
Query: 1543 KDQHLFTHINSTHARLNLQGW-------NNGGCPITAIVLEY---RPKGTWAWQGL-RAN 1591
+ + + ST R++ W NG ++ E +G G+ R +
Sbjct: 610 PQKVMCVSMGSTTVRVS---WVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREH 666
Query: 1592 SSGEVFLTELREATWYELRMRACNSAGCGNETAQ-FATLDYDGSTIPPIK 1640
SS + L L + T Y + +RA G G E++ D D + PP K
Sbjct: 667 SSWD--LVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRK 714
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,803,143
Number of Sequences: 37866
Number of extensions: 4853568
Number of successful extensions: 65523
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 616
Number of HSP's successfully gapped in prelim test: 1206
Number of HSP's that attempted gapping in prelim test: 27718
Number of HSP's gapped (non-prelim): 19780
length of query: 2113
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1995
effective length of database: 13,779,330
effective search space: 27489763350
effective search space used: 27489763350
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.