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Search of human proteins with 21264592
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 2 [Homo sapiens]
(1704 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 3408 0.0
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 847 0.0
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 847 0.0
gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 836 0.0
gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 724 0.0
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 103 1e-21
gi|187608516 centaurin, beta 2 [Homo sapiens] 102 2e-21
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 102 3e-21
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 102 3e-21
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 102 4e-21
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 101 5e-21
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 101 5e-21
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 101 7e-21
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 101 7e-21
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 100 9e-21
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 100 1e-20
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 100 1e-20
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 100 2e-20
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 99 4e-20
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 99 5e-20
gi|7661880 centaurin beta1 [Homo sapiens] 91 7e-18
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 89 5e-17
gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain ... 89 5e-17
gi|156119615 myosin IXA [Homo sapiens] 87 1e-16
gi|46094081 development and differentiation enhancing factor 1 [... 86 4e-16
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 81 1e-14
gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain... 81 1e-14
gi|194272142 myosin IXB isoform 2 [Homo sapiens] 80 2e-14
gi|33356170 myosin IXB isoform 1 [Homo sapiens] 80 2e-14
gi|206725422 G protein-coupled receptor kinase interacting ArfGA... 80 2e-14
>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
[Homo sapiens]
Length = 1704
Score = 3408 bits (8836), Expect = 0.0
Identities = 1704/1704 (100%), Positives = 1704/1704 (100%)
Query: 1 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI 60
MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI
Sbjct: 1 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI 60
Query: 61 LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL 120
LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL
Sbjct: 61 LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL 120
Query: 121 ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES 180
ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES
Sbjct: 121 ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES 180
Query: 181 LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS 240
LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS
Sbjct: 181 LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS 240
Query: 241 PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS 300
PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS
Sbjct: 241 PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS 300
Query: 301 GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE 360
GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE
Sbjct: 301 GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE 360
Query: 361 ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE 420
ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE
Sbjct: 361 ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE 420
Query: 421 CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS 480
CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS
Sbjct: 421 CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS 480
Query: 481 AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD 540
AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD
Sbjct: 481 AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD 540
Query: 541 NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK 600
NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK
Sbjct: 541 NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK 600
Query: 601 AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT 660
AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT
Sbjct: 601 AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT 660
Query: 661 AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC 720
AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC
Sbjct: 661 AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC 720
Query: 721 KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD 780
KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD
Sbjct: 721 KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD 780
Query: 781 SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC 840
SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC
Sbjct: 781 SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC 840
Query: 841 ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY 900
ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY
Sbjct: 841 ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY 900
Query: 901 QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED 960
QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED
Sbjct: 901 QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED 960
Query: 961 FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ 1020
FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ
Sbjct: 961 FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ 1020
Query: 1021 LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV 1080
LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV
Sbjct: 1021 LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV 1080
Query: 1081 LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT 1140
LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT
Sbjct: 1081 LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT 1140
Query: 1141 QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL 1200
QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL
Sbjct: 1141 QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL 1200
Query: 1201 LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN 1260
LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN
Sbjct: 1201 LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN 1260
Query: 1261 AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDT 1320
AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDT
Sbjct: 1261 AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDT 1320
Query: 1321 QVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI 1380
QVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI
Sbjct: 1321 QVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI 1380
Query: 1381 ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI 1440
ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI
Sbjct: 1381 ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI 1440
Query: 1441 LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP 1500
LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP
Sbjct: 1441 LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP 1500
Query: 1501 PTSWGLTAYSEKHHWHLCCDSSRTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIG 1560
PTSWGLTAYSEKHHWHLCCDSSRTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIG
Sbjct: 1501 PTSWGLTAYSEKHHWHLCCDSSRTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIG 1560
Query: 1561 GLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKD 1620
GLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKD
Sbjct: 1561 GLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKD 1620
Query: 1621 DKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVI 1680
DKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVI
Sbjct: 1621 DKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVI 1680
Query: 1681 EELNVVLQRSRTLPKELQDEQILK 1704
EELNVVLQRSRTLPKELQDEQILK
Sbjct: 1681 EELNVVLQRSRTLPKELQDEQILK 1704
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform a [Homo sapiens]
Length = 1205
Score = 847 bits (2188), Expect = 0.0
Identities = 469/1140 (41%), Positives = 682/1140 (59%), Gaps = 63/1140 (5%)
Query: 484 VKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNKF 543
+K+GWLDK PQG ++QKRWV+ D + Y+++ K+ YSK I ++ IS V GD KF
Sbjct: 84 IKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKF 143
Query: 544 EVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVT--------PEKCGYLE 595
EV+T RTF FR E + ER +W+ L A+ Q ++ + P++ G LE
Sbjct: 144 EVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDRAGSLE 203
Query: 596 LRGYKAKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYR 655
LRG+K K++ + G+ V L KN +++ G+GIT I M+V NVK+VDR +SF++ TPYR
Sbjct: 204 LRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDR---RSFDLTTPYR 260
Query: 656 SFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINL 715
FSF+A++E EK+ W+EA+Q +IAE LS EVAE+IW NR CADC AP PDWASINL
Sbjct: 261 IFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPDWASINL 320
Query: 716 CVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDE 775
CVVICK+CAG+HR LG SKVRSLKMD +W+ LIELF+ +GN N FWA N+ E
Sbjct: 321 CVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSE 380
Query: 776 ELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSG 835
L S R+ + KY+EGK+R+ +EEL+KALCAAV D+ ET ALL G
Sbjct: 381 ALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDLAETQALLGCG 440
Query: 836 ADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDI------HSEGVLSQES 889
A + C +GDP TP LA++AGQ+LQMEFL +N+ ++ P+ D H VL S
Sbjct: 441 AGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPTVS 500
Query: 890 SQSTFLCDFLYQAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININ 949
FLY+ S A KL +++ EE +++WCVL G LSY+EN+++ TPNG I +
Sbjct: 501 HSG-----FLYKTAS-AGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRAS 554
Query: 950 EVICLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAEN 1009
E++CLA+ D + G FE+Y ER++LFG E+++ +W + IAK FVP AE+
Sbjct: 555 EIVCLAVPPPDTH---GFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLAED 611
Query: 1010 LTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTIS 1069
L D++ +G+L YK +L + ++GWF++ S L + + + LR+LQEL+I
Sbjct: 612 LLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCE-EPLQLRKLQELSI- 669
Query: 1070 TMVQNGEKLDVLLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVP 1129
Q + VL+LVE+ RTLYI G +LDF W AI+KAA + G+ L +QQL +D+P
Sbjct: 670 ---QGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIP 726
Query: 1130 IIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVL 1189
+IV C+ ++TQ GL + IY+K G LLES ++DARS L+ G+ ++DV++ L
Sbjct: 727 VIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSAL 786
Query: 1190 KSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYR 1249
K FL D+ D L T+ W+ A + +D++E++ +Y + LP VNRAT+ A+I HLY
Sbjct: 787 KRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYC 846
Query: 1250 VQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDI 1309
VQ S+ N MN HNLA+VF LFQT GQ + V+EDLIN+YV +F V E+++++
Sbjct: 847 VQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQRE 906
Query: 1310 ENSFITKWK----DTQVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKN 1365
E + I K + + AGD + VY+E K+ + I++ M AEELT +IL +N
Sbjct: 907 EITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILDRRN 966
Query: 1366 IIPTKGDIWATFEVIENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIK 1425
+ + D W FEV E EE ERPLH+ E VL + + ++LVVK+ + +
Sbjct: 967 VGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGT-----DSHLVVKKHQAMEAML 1021
Query: 1426 HCSDRSTLGSIKEGILKIKEEPSKI---LSGNKFQDRYFVLRDGFLFLYKDVKSS----- 1477
S +G K G++K +E+ S + L F DRYF+L L LYK+V+S
Sbjct: 1022 -LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSG 1080
Query: 1478 ------KHDKMFSLSSMKFYRGVKKKMKPPTSWGLTAY-----SEKHHWHLCCDSSRTQT 1526
+ +K + + S+K Y GVKKK++PPT WG T EK W+LCCD+
Sbjct: 1081 APETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELR 1140
Query: 1527 EWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIGGLPLIPIQHEGNATLARKNIESARAE 1586
EW + QH+ +WP R++ + ++G + LIP++ G+ R+++ + A+
Sbjct: 1141 EWFATFLFVQHDGLVWPSEPSRVSRAVPE-VRLGSVSLIPLR--GSENEMRRSVAAFTAD 1197
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
isoform c [Homo sapiens]
Length = 1450
Score = 847 bits (2188), Expect = 0.0
Identities = 469/1140 (41%), Positives = 682/1140 (59%), Gaps = 63/1140 (5%)
Query: 484 VKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNKF 543
+K+GWLDK PQG ++QKRWV+ D + Y+++ K+ YSK I ++ IS V GD KF
Sbjct: 329 IKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKF 388
Query: 544 EVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVT--------PEKCGYLE 595
EV+T RTF FR E + ER +W+ L A+ Q ++ + P++ G LE
Sbjct: 389 EVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDRAGSLE 448
Query: 596 LRGYKAKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYR 655
LRG+K K++ + G+ V L KN +++ G+GIT I M+V NVK+VDR +SF++ TPYR
Sbjct: 449 LRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDR---RSFDLTTPYR 505
Query: 656 SFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINL 715
FSF+A++E EK+ W+EA+Q +IAE LS EVAE+IW NR CADC AP PDWASINL
Sbjct: 506 IFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPDWASINL 565
Query: 716 CVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDE 775
CVVICK+CAG+HR LG SKVRSLKMD +W+ LIELF+ +GN N FWA N+ E
Sbjct: 566 CVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSE 625
Query: 776 ELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSG 835
L S R+ + KY+EGK+R+ +EEL+KALCAAV D+ ET ALL G
Sbjct: 626 ALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDLAETQALLGCG 685
Query: 836 ADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDI------HSEGVLSQES 889
A + C +GDP TP LA++AGQ+LQMEFL +N+ ++ P+ D H VL S
Sbjct: 686 AGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPTVS 745
Query: 890 SQSTFLCDFLYQAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININ 949
FLY+ S A KL +++ EE +++WCVL G LSY+EN+++ TPNG I +
Sbjct: 746 HSG-----FLYKTAS-AGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRAS 799
Query: 950 EVICLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAEN 1009
E++CLA+ D + G FE+Y ER++LFG E+++ +W + IAK FVP AE+
Sbjct: 800 EIVCLAVPPPDTH---GFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLAED 856
Query: 1010 LTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTIS 1069
L D++ +G+L YK +L + ++GWF++ S L + + + LR+LQEL+I
Sbjct: 857 LLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCE-EPLQLRKLQELSI- 914
Query: 1070 TMVQNGEKLDVLLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVP 1129
Q + VL+LVE+ RTLYI G +LDF W AI+KAA + G+ L +QQL +D+P
Sbjct: 915 ---QGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIP 971
Query: 1130 IIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVL 1189
+IV C+ ++TQ GL + IY+K G LLES ++DARS L+ G+ ++DV++ L
Sbjct: 972 VIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSAL 1031
Query: 1190 KSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYR 1249
K FL D+ D L T+ W+ A + +D++E++ +Y + LP VNRAT+ A+I HLY
Sbjct: 1032 KRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYC 1091
Query: 1250 VQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDI 1309
VQ S+ N MN HNLA+VF LFQT GQ + V+EDLIN+YV +F V E+++++
Sbjct: 1092 VQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQRE 1151
Query: 1310 ENSFITKWK----DTQVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKN 1365
E + I K + + AGD + VY+E K+ + I++ M AEELT +IL +N
Sbjct: 1152 EITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILDRRN 1211
Query: 1366 IIPTKGDIWATFEVIENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIK 1425
+ + D W FEV E EE ERPLH+ E VL + + ++LVVK+ + +
Sbjct: 1212 VGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGT-----DSHLVVKKHQAMEAML 1266
Query: 1426 HCSDRSTLGSIKEGILKIKEEPSKI---LSGNKFQDRYFVLRDGFLFLYKDVKSS----- 1477
S +G K G++K +E+ S + L F DRYF+L L LYK+V+S
Sbjct: 1267 -LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSG 1325
Query: 1478 ------KHDKMFSLSSMKFYRGVKKKMKPPTSWGLTAY-----SEKHHWHLCCDSSRTQT 1526
+ +K + + S+K Y GVKKK++PPT WG T EK W+LCCD+
Sbjct: 1326 APETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELR 1385
Query: 1527 EWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIGGLPLIPIQHEGNATLARKNIESARAE 1586
EW + QH+ +WP R++ + ++G + LIP++ G+ R+++ + A+
Sbjct: 1386 EWFATFLFVQHDGLVWPSEPSRVSRAVPE-VRLGSVSLIPLR--GSENEMRRSVAAFTAD 1442
Score = 44.3 bits (103), Expect = 0.001
Identities = 20/64 (31%), Positives = 36/64 (56%)
Query: 1 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI 60
M+ + + + ++L +++LEQY F + G +C ++D+ L +G+ GHRRRI
Sbjct: 1 MAEAGDAALSVAEWLRALHLEQYTGLFEQHGLVWATECQGLSDTRLMDMGMLLPGHRRRI 60
Query: 61 LKQL 64
L L
Sbjct: 61 LAGL 64
>gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
[Homo sapiens]
Length = 1544
Score = 836 bits (2159), Expect = 0.0
Identities = 482/1179 (40%), Positives = 686/1179 (58%), Gaps = 64/1179 (5%)
Query: 457 SGNADSSAVSSQAISPYACFYGASAK--KVKSGWLDKLSPQGKRMFQKRWVKFDGLSISY 514
S ++ S ISPYA F + + + SGWLDKLSPQG +FQ+R+V+F+G S+ Y
Sbjct: 260 SPTLETEETSDDLISPYASFSFTADRLTPLLSGWLDKLSPQGNYVFQRRFVQFNGRSLMY 319
Query: 515 YNNEKEMYSKGIIPLSAISTVRVQGDNKFEVVTTQRTFVFRVEKEEERNDWISILLNALK 574
+ ++K+ + KG+IPL+AI R DNKF+V+T QR FVFR E E +R+ W S L + LK
Sbjct: 320 FGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLK 379
Query: 575 SQSLTSQSQAVVTPE--KCGYLELRGYKAKIFTVLSGNSVWLCKNEQDFKSGLGITIIPM 632
Q L + P + G LELRG+KAK+F LS + L K+EQ F G+GI I +
Sbjct: 380 EQRLLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIEL 439
Query: 633 NVANVKQVDRTVKQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAEKIW 692
+V++ T +SF+++TP+R FSFTAE+ +Q W A+Q+++ ETLSDYEVAEKIW
Sbjct: 440 QGCSVRE---TKSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIW 496
Query: 693 FNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELI 752
N +NR CADC + PDWA++NL VVICK+CAGQHR+LG SKV+SLK+D S+WSNE++
Sbjct: 497 SNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIV 556
Query: 753 ELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEEL 812
+LFIV+GN RAN FWAG L E LH D+ R FI++KY+ G FRK +L
Sbjct: 557 QLFIVLGNDRANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHPQYPDHSQL 616
Query: 813 NKALCAAVVKPDVLETMALL-----FSGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLY 867
+ALCAAV +P++L+ M L F G + P S P LL
Sbjct: 617 LQALCAAVARPNLLKNMTQLLCVEAFEGEEPWFPPA-PDGSCPGLLPSDP---------- 665
Query: 868 HNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLYQAP-SAASKLSSEKKLLEETNKKWCVL 926
S GV ++ ++T+ FLY +P S + S ++ + + WCVL
Sbjct: 666 -------------SPGVYNEVVVRATY-SGFLYCSPVSNKAGPSPPRRGRDAPPRLWCVL 711
Query: 927 EGGFLSYYENDKSTTPNGTININEVICLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAE 986
G L + ++ S P I +++CL + F FE+ L R+ FG +
Sbjct: 712 -GAALEMFASENSPEPLSLIQPQDIVCLGVSPPPTDPGDRFPFSFELILAGGRIQHFGTD 770
Query: 987 TSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQLFYKD----CHALDQWRKGWFAMDKS 1042
+ + WT A+ K F PL L +G+L+ + A W G+ +
Sbjct: 771 GADSLEAWTSAVGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTAPAPGLWLSGFGLLRGD 830
Query: 1043 SLHFCLQM---QEVQGDRMHLRRLQELTISTMVQNGEKLDVLLLVEKGRTLYIHGHTKLD 1099
L C D +HLRRLQE+++ + +K + L+LVE GRTLY+ G +LD
Sbjct: 831 HLFLCSAPGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRLD 890
Query: 1100 FTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHI 1159
FT W+ AI AAG G LQ+QQ+S+ D+PIIV++CI+FVTQ+GL + +Y+K G
Sbjct: 891 FTAWNAAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARS 950
Query: 1160 SELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDALLTKELYPYWISALDTQDDK 1219
LL F++DARS KLR G+H +EDVT LK F ++DD + + L P W A +
Sbjct: 951 LRLLAEFRRDARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKN 1010
Query: 1220 ERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQT 1279
+R++KY I LP VNR TLA +I HLYRVQKC+ +N M NLAL+F+ +FQT G+
Sbjct: 1011 QRLEKYKDVIGCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGRG 1070
Query: 1280 SEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDTQVSQAGDLLIEVYVERKEP 1339
EV V+++LI+ Y+ +F++ DQV Q+D+E S IT WKD Q+SQAGDL++EVY+E++ P
Sbjct: 1071 EHEVRVLQELIDGYISVFDIDSDQVAQIDLEVSLITTWKDVQLSQAGDLIMEVYIEQQLP 1130
Query: 1340 DCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVIENEELERPLHYKENVLEQV 1399
D + +++SP + AEELTN +L ++ D+W TFE+ E+ ELERPLH KE VLEQ
Sbjct: 1131 DNCVTLKVSPTLTAEELTNQVLEMRGTAAGM-DLWVTFEIREHGELERPLHPKEKVLEQA 1189
Query: 1400 LRWSSLAEPGSAYLVVKRFLTADT------IKHCSDRSTLGSIKEGILKIKEEPSKILSG 1453
L+W L EP SA L++K+ A I+ S R G+L+ +EEP ++L G
Sbjct: 1190 LQWCQLPEPCSASLLLKKVPLAQAGCLFTGIRRESPR-------VGLLRCREEPPRLL-G 1241
Query: 1454 NKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKPPTSWGLTAYSEKH 1513
++FQ+R+F+LR L L K+ KSSK ++ + L K Y G++KK+KPPT WG T EK
Sbjct: 1242 SRFQERFFLLRGRCLLLLKEKKSSKPEREWPLEGAKVYLGIRKKLKPPTPWGFTLILEKM 1301
Query: 1514 HWHLCCDSSRTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIGGLPLIPIQ-HEGN 1572
H +L C +W TSI AQH+ D P + S K G +PL+PI+ +
Sbjct: 1302 HLYLSCTDEDEMWDWTTSILKAQHD-DQQPVVLRRHSSSDLARQKFGTMPLLPIRGDDSG 1360
Query: 1573 ATLARKNIESARAELERLRLSEKCDKESVDSSLKERASM 1611
ATL N ++ R R LS +S S++E+ +
Sbjct: 1361 ATLLSAN-QTLRRLHNRRTLSMFFPMKSSQGSVEEQEEL 1398
Score = 46.6 bits (109), Expect = 2e-04
Identities = 23/58 (39%), Positives = 35/58 (60%)
Query: 8 NVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRILKQLQ 65
++DI +L +++LEQY F G T + L+++GIS TGHR+RIL+ LQ
Sbjct: 6 DLDIAVWLATVHLEQYADTFRRHGLATAGAARGLGHEELKQLGISATGHRKRILRLLQ 63
>gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform d [Homo sapiens]
Length = 1133
Score = 724 bits (1869), Expect = 0.0
Identities = 427/1131 (37%), Positives = 633/1131 (55%), Gaps = 117/1131 (10%)
Query: 484 VKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNKF 543
+K+GWLDK PQG ++QKRWV+ D + Y+++ K+ YSK I ++ IS V GD KF
Sbjct: 84 IKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKF 143
Query: 544 EVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVT--------PEKCGYLE 595
EV+T RTF FR E + ER +W+ L A+ Q ++ + P++ G LE
Sbjct: 144 EVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDRAGSLE 203
Query: 596 LRGYKAKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYR 655
LRG+K K++ + G+ V L KN +++ G+GIT I M+V NVK+VDR +SF++ TPYR
Sbjct: 204 LRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDR---RSFDLTTPYR 260
Query: 656 SFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINL 715
FSF+A++E EK+ W+EA+Q +IAE LS EVAE+IW NR CADC AP PD
Sbjct: 261 IFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPD------ 314
Query: 716 CVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDF--WAGNLQK 773
W++ I L +VI + A + + K
Sbjct: 315 -------------------------------WAS--INLCVVICKRCAGEHRGLGAGVSK 341
Query: 774 DEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLF 833
L MD V E L +ALCAAV D+ ET ALL
Sbjct: 342 VRSLKMDRKV------------------------WTETLIEALCAAVTTTDLAETQALLG 377
Query: 834 SGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDI------HSEGVLSQ 887
GA + C +GDP TP LA++AGQ+LQMEFL +N+ ++ P+ D H VL
Sbjct: 378 CGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPT 437
Query: 888 ESSQSTFLCDFLYQAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTIN 947
S FLY+ SA KL +++ EE +++WCVL G LSY+EN+++ TPNG I
Sbjct: 438 VSHSG-----FLYKTASAG-KLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIR 491
Query: 948 INEVICLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFA 1007
+E++CLA+ D + G FE+Y ER++LFG E+++ +W + IAK FVP A
Sbjct: 492 ASEIVCLAVPPPDTH---GFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLA 548
Query: 1008 ENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELT 1067
E+L D++ +G+L YK +L + ++GWF++ S L + + + LR+LQEL+
Sbjct: 549 EDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCE-EPLQLRKLQELS 607
Query: 1068 ISTMVQNGEKLDVLLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKND 1127
I Q + VL+LVE+ RTLYI G +LDF W AI+KAA + G+ L +QQL +D
Sbjct: 608 I----QGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSD 663
Query: 1128 VPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTA 1187
+P+IV C+ ++TQ GL + IY+K G LLES ++DARS L+ G+ ++DV++
Sbjct: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723
Query: 1188 VLKSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHL 1247
LK FL D+ D L T+ W+ A + +D++E++ +Y + LP VNRAT+ A+I HL
Sbjct: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783
Query: 1248 YRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQM 1307
Y VQ S+ N MN HNLA+VF LFQT GQ + V+EDLIN+YV +F V E+++++
Sbjct: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQ 843
Query: 1308 DIENSFITKWK----DTQVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAI 1363
E + I K + + AGD + VY+E K+ + I++ M AEELT +IL
Sbjct: 844 REEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILDR 903
Query: 1364 KNIIPTKGDIWATFEVIENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADT 1423
+N+ + D W FEV E EE ERPLH+ E VL + + ++LVVK+ +
Sbjct: 904 RNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGT-----DSHLVVKKHQAMEA 958
Query: 1424 IKHCSDRSTLGSIKEGILKIKEEPSKI---LSGNKFQDRYFVLRDGFLFLYKDVKSSKHD 1480
+ S +G K G++K +E+ S + L F DRYF+L L LYK+V+S + +
Sbjct: 959 ML-LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSHRPE 1017
Query: 1481 KMFSLSSMKFYRGVKKKMKPPTSWGLTAY-----SEKHHWHLCCDSSRTQTEWMTSIFIA 1535
K + + S+K Y GVKKK++PPT WG T EK W+LCCD+ EW +
Sbjct: 1018 KEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFV 1077
Query: 1536 QHEYDIWPPAGKERKRSITKNPKIGGLPLIPIQHEGNATLARKNIESARAE 1586
QH+ +WP R++ + ++G + LIP++ G+ R+++ + A+
Sbjct: 1078 QHDGLVWPSEPSRVSRAVPE-VRLGSVSLIPLR--GSENEMRRSVAAFTAD 1125
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 103 bits (257), Expect = 1e-21
Identities = 78/279 (27%), Positives = 128/279 (45%), Gaps = 27/279 (9%)
Query: 638 KQVDRTVKQSFEIITPY-RSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVA-------- 688
K + + +F I++ +++ F A T +E+ W++A+Q I +L E +
Sbjct: 378 KHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTS 437
Query: 689 -------EKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLK 741
+ I N C DC+ +P WAS+NL V++C +C+G HRSLG + S+VRSL+
Sbjct: 438 QSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLE 497
Query: 742 MDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRK 801
+D W EL ++ IGN AN W G+ Q + S E+++ +I KY+E F
Sbjct: 498 LDD--WPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLA 555
Query: 802 TLLASLTKEELNKALCAAVVKPDVLETMALLFSGA----DVMCATGDPVHSTPYLLAKKA 857
L T+ L + L A D+ + LL G+ + C GD + +L +K
Sbjct: 556 PL--PCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGC-TALHLACRKG 612
Query: 858 GQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLC 896
L +++ D D H L+ S+ C
Sbjct: 613 NVVLAQLLIWYG--VDVMARDAHGNTALTYARQASSQEC 649
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 102 bits (255), Expect = 2e-21
Identities = 73/231 (31%), Positives = 109/231 (47%), Gaps = 36/231 (15%)
Query: 618 EQDFKSGLGITIIPMNVANVKQVDRTVKQ-SFEIITPYRSFSFTAETEKEKQDWIEAVQQ 676
++ FK + + + + VK + ++ FE+++P +S A++EK +Q WI+AVQ
Sbjct: 299 QKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQT 358
Query: 677 SIAETL----------------------SDYEVAEKIWFNES----------NRSCADCK 704
SIA S E EK+ ES N SC DC
Sbjct: 359 SIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCG 418
Query: 705 APDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRAN 764
DP WASINL + +C +C+G HRSLG SKVRSL +D W EL++L +GN N
Sbjct: 419 LADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDT--WEPELLKLMCELGNDVIN 476
Query: 765 DFWAGNLQK-DEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNK 814
+ N++K + ++++ +I KY E KF SL+ E K
Sbjct: 477 RVYEANVEKMGIKKPQPGQRQEKEAYIRAKYVERKFVDKYSISLSPPEQQK 527
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 102 bits (254), Expect = 3e-21
Identities = 74/257 (28%), Positives = 118/257 (45%), Gaps = 26/257 (10%)
Query: 659 FTAETEKEKQDWIEAVQQSIAETLSDYEVA---------------EKIWFNESNRSCADC 703
F A T +E+ W++A+Q I +L E + + I N C DC
Sbjct: 287 FKATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDC 346
Query: 704 KAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRA 763
+ +P WAS+NL V++C +C+G HRSLG + S+VRSL++D W EL ++ IGN A
Sbjct: 347 ETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDD--WPVELRKVMSSIGNDLA 404
Query: 764 NDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKP 823
N W G+ Q + ++S E+++ +I KY+ F L T+ L + L A
Sbjct: 405 NSIWEGSSQGQTKPSIESTREEKERWIRSKYEHKLFLAPL--PCTELSLGQHLLRATADE 462
Query: 824 DVLETMALLFSGA----DVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDI 879
D+ + LL G+ + C GD + +L +K L +++ D D
Sbjct: 463 DLRTAILLLAHGSREEVNETCGEGDGC-TALHLACRKGNVVLAQLLIWYG--VDVMARDA 519
Query: 880 HSEGVLSQESSQSTFLC 896
H L+ S+ C
Sbjct: 520 HGNTALTYARQASSQEC 536
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 102 bits (254), Expect = 3e-21
Identities = 78/279 (27%), Positives = 128/279 (45%), Gaps = 27/279 (9%)
Query: 638 KQVDRTVKQSFEIITPY-RSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVA-------- 688
K + + +F I++ +++ F A T +E+ W++A+Q I +L E +
Sbjct: 378 KHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTS 437
Query: 689 -------EKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLK 741
+ I N C DC+ +P WAS+NL V++C +C+G HRSLG + S+VRSL+
Sbjct: 438 QSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLE 497
Query: 742 MDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRK 801
+D W EL ++ IGN AN W G+ Q + S E+++ +I KY+E F
Sbjct: 498 LDD--WPVELRKVMSSIGNDLANSIWEGSSQGRTKPTEKSTREEKERWIRSKYEEKLFLA 555
Query: 802 TLLASLTKEELNKALCAAVVKPDVLETMALLFSGA----DVMCATGDPVHSTPYLLAKKA 857
L T+ L + L A D+ + LL G+ + C GD + +L +K
Sbjct: 556 PL--PCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGC-TALHLACRKG 612
Query: 858 GQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLC 896
L +++ D D H L+ S+ C
Sbjct: 613 NVVLAQLLIWYG--VDVMARDAHGNTALTYARQASSQEC 649
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 102 bits (253), Expect = 4e-21
Identities = 78/279 (27%), Positives = 127/279 (45%), Gaps = 27/279 (9%)
Query: 638 KQVDRTVKQSFEIITPY-RSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVA-------- 688
K + + +F I++ +++ F A T +E+ W++A+Q I +L E +
Sbjct: 401 KHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTS 460
Query: 689 -------EKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLK 741
+ I N C DC+ +P WAS+NL V++C +C+G HRSLGP S+VRSL+
Sbjct: 461 QSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLE 520
Query: 742 MDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRK 801
+D W EL ++ I N AN W G+ Q + S E+++ +I KY+E F
Sbjct: 521 LDD--WPVELRKVMSSIVNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLA 578
Query: 802 TLLASLTKEELNKALCAAVVKPDVLETMALLFSGA----DVMCATGDPVHSTPYLLAKKA 857
L T+ L + L A D+ + LL G+ + C GD + +L +K
Sbjct: 579 PL--PCTELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGC-TALHLACRKG 635
Query: 858 GQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLC 896
L +++ D D H L+ S+ C
Sbjct: 636 NVVLAQLLIWYG--VDVMARDAHGNTALTYARQASSQEC 672
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 101 bits (252), Expect = 5e-21
Identities = 79/290 (27%), Positives = 129/290 (44%), Gaps = 29/290 (10%)
Query: 655 RSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVA---------------EKIWFNESNRS 699
+++ F A T +E+ W++A++ I +L E + + I N
Sbjct: 511 QTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSH 570
Query: 700 CADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIG 759
C DC+ +P+WAS+NL ++C +C+G HR+LG S+VRSL +D W ELI++ IG
Sbjct: 571 CVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDD--WPVELIKVMSSIG 628
Query: 760 NKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAA 819
N+ AN W + Q + +DS E+++ +I KY++ F L T+ L + L A
Sbjct: 629 NELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPL--PCTELSLGQHLLRA 686
Query: 820 VVKPDVLETMALLFSGA----DVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFP 875
D+ + LL G+ + C GD + +L +K L +++ D
Sbjct: 687 TADEDLRTAILLLAHGSRDEVNETCGEGDG-RTALHLACRKGNVVLAQLLIWYG--VDVT 743
Query: 876 QHDIHSEGVLS---QESSQSTFLCDFLYQAPSAASKLSSEKKLLEETNKK 922
D H L+ Q SSQ Y P L + L N +
Sbjct: 744 ARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLSRRNNNR 793
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 101 bits (252), Expect = 5e-21
Identities = 79/290 (27%), Positives = 129/290 (44%), Gaps = 29/290 (10%)
Query: 655 RSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVA---------------EKIWFNESNRS 699
+++ F A T +E+ W++A++ I +L E + + I N
Sbjct: 564 QTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSH 623
Query: 700 CADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIG 759
C DC+ +P+WAS+NL ++C +C+G HR+LG S+VRSL +D W ELI++ IG
Sbjct: 624 CVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDD--WPVELIKVMSSIG 681
Query: 760 NKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAA 819
N+ AN W + Q + +DS E+++ +I KY++ F L T+ L + L A
Sbjct: 682 NELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPL--PCTELSLGQHLLRA 739
Query: 820 VVKPDVLETMALLFSGA----DVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFP 875
D+ + LL G+ + C GD + +L +K L +++ D
Sbjct: 740 TADEDLRTAILLLAHGSRDEVNETCGEGDG-RTALHLACRKGNVVLAQLLIWYG--VDVT 796
Query: 876 QHDIHSEGVLS---QESSQSTFLCDFLYQAPSAASKLSSEKKLLEETNKK 922
D H L+ Q SSQ Y P L + L N +
Sbjct: 797 ARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLSRRNNNR 846
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 101 bits (251), Expect = 7e-21
Identities = 64/193 (33%), Positives = 100/193 (51%), Gaps = 19/193 (9%)
Query: 655 RSFSFTAETEKEKQDWIEAVQQSIAETL---------------SDYEVAEKIWFNESNRS 699
+++ F A + +E+ W++A++ I +L S+ + I + N
Sbjct: 886 QTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSI 945
Query: 700 CADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIG 759
C DC AP+P WAS+NL +IC +C+G HR+LG S+VRSL +D W EL + IG
Sbjct: 946 CVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDD--WPRELTLVLTAIG 1003
Query: 760 NKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAA 819
N AN W + + + DS E+R+++I KY++ F L S ++E L + L AA
Sbjct: 1004 NDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPL--STSEEPLGRQLWAA 1061
Query: 820 VVKPDVLETMALL 832
V DV + LL
Sbjct: 1062 VQAQDVATVLLLL 1074
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 101 bits (251), Expect = 7e-21
Identities = 64/193 (33%), Positives = 100/193 (51%), Gaps = 19/193 (9%)
Query: 655 RSFSFTAETEKEKQDWIEAVQQSIAETL---------------SDYEVAEKIWFNESNRS 699
+++ F A + +E+ W++A++ I +L S+ + I + N
Sbjct: 530 QTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSI 589
Query: 700 CADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIG 759
C DC AP+P WAS+NL +IC +C+G HR+LG S+VRSL +D W EL + IG
Sbjct: 590 CVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDD--WPRELTLVLTAIG 647
Query: 760 NKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAA 819
N AN W + + + DS E+R+++I KY++ F L S ++E L + L AA
Sbjct: 648 NDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPL--STSEEPLGRQLWAA 705
Query: 820 VVKPDVLETMALL 832
V DV + LL
Sbjct: 706 VQAQDVATVLLLL 718
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 100 bits (250), Expect = 9e-21
Identities = 77/279 (27%), Positives = 127/279 (45%), Gaps = 27/279 (9%)
Query: 638 KQVDRTVKQSFEIITPY-RSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVA-------- 688
K + + +F I++ +++ F A T +E+ W++A+Q I +L E +
Sbjct: 378 KHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTS 437
Query: 689 -------EKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLK 741
+ I N C DC+ +P WAS+NL V++C +C+G H SLG + S+VRSL+
Sbjct: 438 QSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLE 497
Query: 742 MDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRK 801
+D W EL ++ IGN AN W G+ Q + S E+++ +I KY+E F
Sbjct: 498 LDD--WPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLA 555
Query: 802 TLLASLTKEELNKALCAAVVKPDVLETMALLFSGA----DVMCATGDPVHSTPYLLAKKA 857
L T+ L + L A D+ + LL G+ + C GD + +L +K
Sbjct: 556 PL--PCTELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGC-TALHLACRKG 612
Query: 858 GQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLC 896
L +++ D D H L+ S+ C
Sbjct: 613 NVVLAQLLIWYG--VDVMARDAHGNTALTYARQASSQEC 649
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 100 bits (249), Expect = 1e-20
Identities = 68/227 (29%), Positives = 112/227 (49%), Gaps = 24/227 (10%)
Query: 638 KQVDRTVKQSFEIITPY-RSFSFTAETEKEKQDWIEAVQQSIAETL-------------- 682
K + + +F I++ +++ F A T +E+ W++A+Q I +L
Sbjct: 401 KHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTS 460
Query: 683 -SDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLK 741
S+ + I N C DC+ +P WAS+NL V++C +C+G HRS G + S+VRSL+
Sbjct: 461 QSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLE 520
Query: 742 MDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRK 801
+D W EL ++ IGN+ AN W G+ Q + + S E+++ +I KY+E F
Sbjct: 521 LDD--WPVELRKVMSSIGNELANSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLA 578
Query: 802 TLLASLTKEELNKALCAAVVKPDVLETMALLFSGA----DVMCATGD 844
L T+ L + L A D+ + LL G+ + C GD
Sbjct: 579 PL--PCTELSLGQQLLRATTDEDLQTAILLLAHGSREEVNETCGEGD 623
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 100 bits (249), Expect = 1e-20
Identities = 68/227 (29%), Positives = 112/227 (49%), Gaps = 24/227 (10%)
Query: 638 KQVDRTVKQSFEIITPY-RSFSFTAETEKEKQDWIEAVQQSIAETL-------------- 682
K + + +F I++ +++ F A T +E+ W++A+Q I +L
Sbjct: 401 KHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTS 460
Query: 683 -SDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLK 741
S+ + I N C DC+ +P WAS+NL V++C +C+G HRS G + S+VRSL+
Sbjct: 461 QSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLE 520
Query: 742 MDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRK 801
+D W EL ++ IGN+ AN W G+ Q + + S E+++ +I KY+E F
Sbjct: 521 LDD--WPVELRKVMSSIGNELANSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLA 578
Query: 802 TLLASLTKEELNKALCAAVVKPDVLETMALLFSGA----DVMCATGD 844
L T+ L + L A D+ + LL G+ + C GD
Sbjct: 579 PL--PCTELSLGQQLLRATTDEDLQTAILLLAHGSREEVNETCGEGD 623
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 100 bits (248), Expect = 2e-20
Identities = 77/279 (27%), Positives = 128/279 (45%), Gaps = 27/279 (9%)
Query: 638 KQVDRTVKQSFEIITPY-RSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVA-------- 688
K + + +F I++ +++ F A T +E+ W++A+Q I +L E +
Sbjct: 401 KHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTS 460
Query: 689 -------EKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLK 741
+ I N C D + +P WAS+NL V++C +C+G HRSLG + S+VRSL+
Sbjct: 461 QSEAMALQSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLE 520
Query: 742 MDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRK 801
+D W EL ++ IGN AN W G+ Q + + S E+++ +I KY+E F
Sbjct: 521 LDD--WPVELRKVMSSIGNDLANSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLA 578
Query: 802 TLLASLTKEELNKALCAAVVKPDVLETMALLFSGA----DVMCATGDPVHSTPYLLAKKA 857
L T+ L + L A D+ + LL G+ + C GD + +L +K
Sbjct: 579 PL--PCTELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGC-TALHLACRKG 635
Query: 858 GQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLC 896
L +++ D D H L+ S+ C
Sbjct: 636 NVVLAQLLIWYG--VDVMARDAHGNTALTYARQASSQEC 672
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 99.0 bits (245), Expect = 4e-20
Identities = 67/212 (31%), Positives = 107/212 (50%), Gaps = 26/212 (12%)
Query: 645 KQSFEIITPY---RSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVA------------- 688
++SFE + +++ F A T +E++ W+++VQ I +L A
Sbjct: 604 EESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAAL 663
Query: 689 --EKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASI 746
+ + N C DC AP+PDWAS+NL ++C +C+G HR LG S+VRSL +D
Sbjct: 664 AVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDD-- 721
Query: 747 WSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLAS 806
W EL+ + +GN AN W G L + D+ E+++ +I KY++ K LA
Sbjct: 722 WPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQ----KLFLAP 777
Query: 807 LTKEE--LNKALCAAVVKPDVLETMALLFSGA 836
L + L + L AVV+ D+ + LL G+
Sbjct: 778 LPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGS 809
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 98.6 bits (244), Expect = 5e-20
Identities = 66/226 (29%), Positives = 106/226 (46%), Gaps = 40/226 (17%)
Query: 618 EQDFKSGLGITIIPMNVANVKQVDRTVKQ-SFEIITPYRSFSFTAETEKEKQDWIEAVQQ 676
++ K L + + + + +VK + ++ FE+++P +S A++EK +Q W++AVQ
Sbjct: 301 QKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQA 360
Query: 677 SIAETLSDY----------------------------------EVAEKIWFNESNRSCAD 702
SIA + V +++ N C D
Sbjct: 361 SIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGD 420
Query: 703 CKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKR 762
C PDP WASINL V++C +C+G HRSLG SKVRSL +D+ W EL++L +GN
Sbjct: 421 CGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDS--WEPELLKLMCELGNSA 478
Query: 763 ANDFWAGNLQ--KDEELHMDSPVEKRKNFITQKYKEGKF-RKTLLA 805
N + + + S + ++ +I KY E KF RK +A
Sbjct: 479 VNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAPMA 524
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 91.3 bits (225), Expect = 7e-18
Identities = 93/351 (26%), Positives = 139/351 (39%), Gaps = 94/351 (26%)
Query: 604 FTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQV-DRTVKQSFEIITPYRSFSFTAE 662
FT+ S V+ ++ +K + + + + + VK D + FE+++ +S A+
Sbjct: 288 FTIQSNQLVY----QKKYKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCLLQAD 343
Query: 663 TEKEKQDWIEAVQQSIAETLSDYE------------------------------------ 686
+E+ Q W+ AVQ SIA S
Sbjct: 344 SERLLQLWVSAVQSSIASAFSQARLDDSPRGPGQGSGHLAIGSAATLGSGGMARGREPGG 403
Query: 687 ---VAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMD 743
V ++ + N C DC+ P P+WASINL V +C +C+G HRSLG SKVRSL +D
Sbjct: 404 VGHVVAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLD 463
Query: 744 ASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSP-----VEKRKNFITQKYKEGK 798
+ W EL++L +GN N + + E + + P ++++ +I KY E K
Sbjct: 464 S--WEPELVKLMCELGNVIINQIYEARV---EAMAVKKPGPSCSRQEKEAWIHAKYVEKK 518
Query: 799 F-------------------------------RKTLLASLTK---EELNK-----ALCAA 819
F R L S + E+L L A
Sbjct: 519 FLTKLPEIRGRRGGRGRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDLGSLHPGALLFRA 578
Query: 820 VVKPDVLETMA-LLFSGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHN 869
P L TMA L GADV G ++TP + A A L EFL N
Sbjct: 579 SGHPPSLPTMADALAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQN 629
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 88.6 bits (218), Expect = 5e-17
Identities = 63/214 (29%), Positives = 105/214 (49%), Gaps = 24/214 (11%)
Query: 645 KQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDY------------------E 686
K+ F++I+ R++ F AE E+E Q W+ +Q S E L++ E
Sbjct: 363 KKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKE 422
Query: 687 VAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASI 746
+ ++ N C DC APDP W S NL ++ C +C+G HR LG S+++SL +D +
Sbjct: 423 IISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDV-L 481
Query: 747 WSNELIELFIVIGNKRANDFWAGNLQKDEEL--HMDSPVEKRKNFITQKYKEGKFRKTLL 804
++EL+ L IGN N+ L ++ + + S + RK++IT KY E ++ +
Sbjct: 482 GTSELL-LAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKH 540
Query: 805 ASLTKEELNKALCAAVVKPDVLETMALLFSGADV 838
A + +LC AV D+ + G D+
Sbjct: 541 ADNAAK--LHSLCEAVKTRDIFGLLQAYADGVDL 572
Score = 32.0 bits (71), Expect = 5.3
Identities = 27/100 (27%), Positives = 53/100 (53%), Gaps = 9/100 (9%)
Query: 485 KSGWLDKLSPQGKRMFQKRW--VKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNK 542
++G L K S ++++QKR VK L+IS+ + ++ V+ + K
Sbjct: 308 RNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQ----VKTNPEEK 363
Query: 543 --FEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTS 580
F++++ RT+ F+ E E+E W+S+L N+ K ++L +
Sbjct: 364 KCFDLISHDRTYHFQAEDEQECQIWMSVLQNS-KEEALNN 402
>gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform a [Homo sapiens]
Length = 1006
Score = 88.6 bits (218), Expect = 5e-17
Identities = 63/214 (29%), Positives = 105/214 (49%), Gaps = 24/214 (11%)
Query: 645 KQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDY------------------E 686
K+ F++I+ R++ F AE E+E Q W+ +Q S E L++ E
Sbjct: 363 KKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKE 422
Query: 687 VAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASI 746
+ ++ N C DC APDP W S NL ++ C +C+G HR LG S+++SL +D +
Sbjct: 423 IISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDV-L 481
Query: 747 WSNELIELFIVIGNKRANDFWAGNLQKDEEL--HMDSPVEKRKNFITQKYKEGKFRKTLL 804
++EL+ L IGN N+ L ++ + + S + RK++IT KY E ++ +
Sbjct: 482 GTSELL-LAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKH 540
Query: 805 ASLTKEELNKALCAAVVKPDVLETMALLFSGADV 838
A + +LC AV D+ + G D+
Sbjct: 541 ADNAAK--LHSLCEAVKTRDIFGLLQAYADGVDL 572
Score = 32.0 bits (71), Expect = 5.3
Identities = 27/100 (27%), Positives = 53/100 (53%), Gaps = 9/100 (9%)
Query: 485 KSGWLDKLSPQGKRMFQKRW--VKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNK 542
++G L K S ++++QKR VK L+IS+ + ++ V+ + K
Sbjct: 308 RNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQ----VKTNPEEK 363
Query: 543 --FEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTS 580
F++++ RT+ F+ E E+E W+S+L N+ K ++L +
Sbjct: 364 KCFDLISHDRTYHFQAEDEQECQIWMSVLQNS-KEEALNN 402
>gi|156119615 myosin IXA [Homo sapiens]
Length = 2548
Score = 87.0 bits (214), Expect = 1e-16
Identities = 97/393 (24%), Positives = 171/393 (43%), Gaps = 34/393 (8%)
Query: 1128 VPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTA 1187
VP++V I ++ +GL + IY+K+G I EL + DA S L + + + +
Sbjct: 2075 VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNL--DDYNIHVIAS 2132
Query: 1188 VLKSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHL 1247
V K +L D+ + L+T ELY ++ A+ Q+ KE I+ + I L + TL +I HL
Sbjct: 2133 VFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLNTLERLIFHL 2192
Query: 1248 YRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVNVIEDLIN-----NYVEIFEVKED 1302
R+ + N M+A+ LA+VF+ C+ + T++ + ++D+ + + ++ +
Sbjct: 2193 VRIALQEDTNRMSANALAIVFAPCILRCP-DTTDPLQSVQDISKTTTCVELIVVEQMNKY 2251
Query: 1303 QVKQMDIEN-SFITKWKDTQVSQAGDLLIEVYVERKE---PDCSIIIRISPVMEAEE--L 1356
+ + DI + F T++S + + + R P +++R+ V + E L
Sbjct: 2252 KARLKDISSLEFAENKAKTRLSLIRRSMGKGRIRRGNYPGPSSPVVVRLPSVSDVSEETL 2311
Query: 1357 TNDILAIKNIIPTKGDIWATFEVIENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVK 1416
T++ +I + E + E++E KE + ++L A
Sbjct: 2312 TSEAAMETDITEQQQAAMQQEERVLTEQIENLQKEKEELTFEMLVLEPRASDDETLESEA 2371
Query: 1417 RFLTADT-----------IKHCSDRS-TLGSIKEGILKIKEEPSKILSG--NKFQDRYFV 1462
TAD+ I S+RS L S+K K EPS L K QD V
Sbjct: 2372 SIGTADSSENLNMESEYAISEKSERSLALSSLKTA---GKSEPSSKLRKQLKKQQDSLDV 2428
Query: 1463 LRDGFLFLYKDVKSSKHD--KMFSL-SSMKFYR 1492
+ L +S H K+F + S FYR
Sbjct: 2429 VDSSVSSLCLSNTASSHGTRKLFQIYSKSPFYR 2461
>gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
Length = 1129
Score = 85.5 bits (210), Expect = 4e-16
Identities = 63/214 (29%), Positives = 106/214 (49%), Gaps = 24/214 (11%)
Query: 645 KQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLS-----------------DYEV 687
K+SF++I+ R++ F AE E++ WI + S E L+ +
Sbjct: 382 KKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAI 441
Query: 688 AEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIW 747
E + N C DC + +P W S NL ++ C +C+G HR +G S+++SL++D +
Sbjct: 442 IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELD-KLG 500
Query: 748 SNELIELFIVIGNKRANDFWAGNL-QKDEELHMDSPVEKRKNFITQKYKEGKF-RKTLLA 805
++EL+ L +GN ND NL + S + RK +IT KY + +F RKT
Sbjct: 501 TSELL-LAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKT--C 557
Query: 806 SLTKEELNKALCAAVVKPDVLETMALLFSGADVM 839
S + +LN+ L A+ D+L + + G ++M
Sbjct: 558 STSSAKLNE-LLEAIKSRDLLALIQVYAEGVELM 590
Score = 37.4 bits (85), Expect = 0.13
Identities = 26/97 (26%), Positives = 52/97 (53%), Gaps = 5/97 (5%)
Query: 485 KSGWLDKLSPQGKRMFQKRW--VKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNK 542
K G+L K S ++++Q+R VK L+IS+ + ++ ++ +
Sbjct: 327 KKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQV--KPNAEDKKS 384
Query: 543 FEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLT 579
F++++ RT+ F+ E E++ WIS+L N+ K ++LT
Sbjct: 385 FDLISHNRTYHFQAEDEQDYVAWISVLTNS-KEEALT 420
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 80.9 bits (198), Expect = 1e-14
Identities = 61/221 (27%), Positives = 100/221 (45%), Gaps = 36/221 (16%)
Query: 645 KQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAE--------------- 689
K+ F+++T R++ F AE E E + W+ +Q S E LS + E
Sbjct: 351 KKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDG 410
Query: 690 -----------KIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVR 738
++ N C DC A DP W S NL V+ C +C+G HR LG + S+++
Sbjct: 411 EPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQ 470
Query: 739 SLKMDASIWSNELIELFIVIGNKRANDFWAGNLQK--DEELHMDSPVEKRKNFITQKYKE 796
SL +D + +EL+ L + +GN N+ L + +S + R+++I KY E
Sbjct: 471 SLTLDL-LGPSELL-LALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVE 528
Query: 797 GKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGAD 837
+F + T E + L A+ D+L + +G D
Sbjct: 529 HRFAR----RCTPEP--QRLWTAICNRDLLSVLEAFANGQD 563
Score = 41.2 bits (95), Expect = 0.009
Identities = 33/100 (33%), Positives = 54/100 (54%), Gaps = 9/100 (9%)
Query: 485 KSGWLDKLSPQGKRMFQKR--WVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNK 542
K G+L K S +R++QKR VK+ L+IS+ + ++ VR + K
Sbjct: 296 KVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQ----VRPNPEEK 351
Query: 543 --FEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTS 580
F++VT RT+ F+ E E E W+S+L N+ K ++L+S
Sbjct: 352 KCFDLVTHNRTYHFQAEDEHECEAWVSVLQNS-KDEALSS 390
>gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform a [Homo sapiens]
Length = 903
Score = 80.9 bits (198), Expect = 1e-14
Identities = 61/221 (27%), Positives = 100/221 (45%), Gaps = 36/221 (16%)
Query: 645 KQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAE--------------- 689
K+ F+++T R++ F AE E E + W+ +Q S E LS + E
Sbjct: 360 KKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDG 419
Query: 690 -----------KIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVR 738
++ N C DC A DP W S NL V+ C +C+G HR LG + S+++
Sbjct: 420 EPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQ 479
Query: 739 SLKMDASIWSNELIELFIVIGNKRANDFWAGNLQK--DEELHMDSPVEKRKNFITQKYKE 796
SL +D + +EL+ L + +GN N+ L + +S + R+++I KY E
Sbjct: 480 SLTLDL-LGPSELL-LALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVE 537
Query: 797 GKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGAD 837
+F + T E + L A+ D+L + +G D
Sbjct: 538 HRFAR----RCTPEP--QRLWTAICNRDLLSVLEAFANGQD 572
Score = 41.2 bits (95), Expect = 0.009
Identities = 33/100 (33%), Positives = 54/100 (54%), Gaps = 9/100 (9%)
Query: 485 KSGWLDKLSPQGKRMFQKR--WVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNK 542
K G+L K S +R++QKR VK+ L+IS+ + ++ VR + K
Sbjct: 305 KVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQ----VRPNPEEK 360
Query: 543 --FEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTS 580
F++VT RT+ F+ E E E W+S+L N+ K ++L+S
Sbjct: 361 KCFDLVTHNRTYHFQAEDEHECEAWVSVLQNS-KDEALSS 399
>gi|194272142 myosin IXB isoform 2 [Homo sapiens]
Length = 2022
Score = 79.7 bits (195), Expect = 2e-14
Identities = 48/197 (24%), Positives = 98/197 (49%), Gaps = 11/197 (5%)
Query: 1125 KNDVPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLED 1184
K VPI++ + V +GL + +Y+K+G EL ++ + D + KL +
Sbjct: 1709 KASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLE--NFPIHA 1766
Query: 1185 VTAVLKSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAII 1244
+T VLK +L ++ + L+T Y ++ A++ + +E++ A + LP N +L +I
Sbjct: 1767 ITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLI 1826
Query: 1245 EHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVNV---------IEDLINNYVE 1295
HL +V ++N M+ LA++F+ CL + + ++ +E LI +
Sbjct: 1827 FHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMR 1886
Query: 1296 IFEVKEDQVKQMDIENS 1312
++VK +++ Q++ S
Sbjct: 1887 KYKVKMEEISQLEAAES 1903
>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
Length = 2157
Score = 79.7 bits (195), Expect = 2e-14
Identities = 48/197 (24%), Positives = 98/197 (49%), Gaps = 11/197 (5%)
Query: 1125 KNDVPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLED 1184
K VPI++ + V +GL + +Y+K+G EL ++ + D + KL +
Sbjct: 1709 KASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLE--NFPIHA 1766
Query: 1185 VTAVLKSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAII 1244
+T VLK +L ++ + L+T Y ++ A++ + +E++ A + LP N +L +I
Sbjct: 1767 ITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLI 1826
Query: 1245 EHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVNV---------IEDLINNYVE 1295
HL +V ++N M+ LA++F+ CL + + ++ +E LI +
Sbjct: 1827 FHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMR 1886
Query: 1296 IFEVKEDQVKQMDIENS 1312
++VK +++ Q++ S
Sbjct: 1887 KYKVKMEEISQLEAAES 1903
>gi|206725422 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 5 [Homo sapiens]
Length = 729
Score = 79.7 bits (195), Expect = 2e-14
Identities = 60/183 (32%), Positives = 88/183 (48%), Gaps = 15/183 (8%)
Query: 696 SNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELF 755
S+ CADC PDP WAS+N +C +C HRSLG S+VR LK + W L+++
Sbjct: 7 SSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLK--HTPWPPTLLQMV 64
Query: 756 IVIGNKRANDFWAGNLQKDEEL----HMDSPVEK----RKNFITQKYKEGKFRKTLLA-- 805
+ N AN W +L + +P +K + FI KY+ F L
Sbjct: 65 ETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCRD 124
Query: 806 --SLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQM 863
S+T ++L+K L ++V ++ + LL GA + +TP +A KAGQ LQ
Sbjct: 125 DDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEK-GNTPLHVASKAGQILQA 183
Query: 864 EFL 866
E L
Sbjct: 184 ELL 186
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,995,408
Number of Sequences: 37866
Number of extensions: 2833643
Number of successful extensions: 9242
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 172
Number of HSP's successfully gapped in prelim test: 124
Number of HSP's that attempted gapping in prelim test: 8508
Number of HSP's gapped (non-prelim): 717
length of query: 1704
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1588
effective length of database: 13,855,062
effective search space: 22001838456
effective search space used: 22001838456
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.