Guide to the Human Genome
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Search of human proteins with 209862843

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|209862843 nuclear factor of activated T-cells, cytoplasmic,
calcineurin-dependent 2 isoform D [Homo sapiens]
         (901 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|209862843 nuclear factor of activated T-cells, cytoplasmic, c...  1848   0.0  
gi|27886539 nuclear factor of activated T-cells, cytoplasmic, ca...  1801   0.0  
gi|27886541 nuclear factor of activated T-cells, cytoplasmic, ca...  1773   0.0  
gi|27502386 nuclear factor of activated T-cells, cytosolic compo...   595   e-170
gi|19923350 nuclear factor of activated T-cells, cytosolic compo...   580   e-165
gi|27502391 nuclear factor of activated T-cells, cytosolic compo...   579   e-165
gi|27502393 nuclear factor of activated T-cells, cytosolic compo...   525   e-149
gi|27886561 nuclear factor of activated T-cells, cytoplasmic, ca...   451   e-126
gi|27886559 nuclear factor of activated T-cells, cytoplasmic, ca...   451   e-126
gi|27886555 nuclear factor of activated T-cells, cytoplasmic, ca...   451   e-126
gi|4758804 nuclear factor of activated T-cells, cytoplasmic, cal...   451   e-126
gi|209862845 nuclear factor of activated T-cells, cytoplasmic, c...   426   e-119
gi|27886563 nuclear factor of activated T-cells, cytoplasmic, ca...   426   e-119
gi|27502388 nuclear factor of activated T-cells, cytosolic compo...   387   e-107
gi|27886520 nuclear factor of activated T-cells 5 isoform a [Hom...   221   2e-57
gi|5729945 nuclear factor of activated T-cells 5 isoform c [Homo...   221   2e-57
gi|164419746 nuclear factor of activated T-cells 5 isoform d [Ho...   221   2e-57
gi|164419744 nuclear factor of activated T-cells 5 isoform b [Ho...   221   2e-57
gi|27886524 nuclear factor of activated T-cells 5 isoform a [Hom...   221   2e-57
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    62   2e-09
gi|163965366 nascent polypeptide-associated complex alpha subuni...    60   9e-09
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    54   9e-07
gi|237757310 synaptojanin 1 isoform a [Homo sapiens]                   53   1e-06
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    52   3e-06
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    52   3e-06
gi|237757308 synaptojanin 1 isoform b [Homo sapiens]                   51   4e-06
gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [...    51   4e-06
gi|237757326 synaptojanin 1 isoform d [Homo sapiens]                   51   6e-06
gi|41281612 zinc finger protein 828 [Homo sapiens]                     51   6e-06
gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]             50   9e-06

>gi|209862843 nuclear factor of activated T-cells, cytoplasmic,
           calcineurin-dependent 2 isoform D [Homo sapiens]
          Length = 901

 Score = 1848 bits (4787), Expect = 0.0
 Identities = 901/901 (100%), Positives = 901/901 (100%)

Query: 1   MQREAAFRLGHCHPLRIMGSVDQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSG 60
           MQREAAFRLGHCHPLRIMGSVDQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSG
Sbjct: 1   MQREAAFRLGHCHPLRIMGSVDQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSG 60

Query: 61  EPPGRFGEPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQP 120
           EPPGRFGEPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQP
Sbjct: 61  EPPGRFGEPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQP 120

Query: 121 PLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDD 180
           PLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDD
Sbjct: 121 PLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDD 180

Query: 181 LCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEAL 240
           LCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEAL
Sbjct: 181 LCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEAL 240

Query: 241 VALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPP 300
           VALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPP
Sbjct: 241 VALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPP 300

Query: 301 KMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLV 360
           KMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLV
Sbjct: 301 KMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLV 360

Query: 361 PAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGH 420
           PAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGH
Sbjct: 361 PAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGH 420

Query: 421 PVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLE 480
           PVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLE
Sbjct: 421 PVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLE 480

Query: 481 IPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSL 540
           IPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSL
Sbjct: 481 IPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSL 540

Query: 541 QTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQ 600
           QTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQ
Sbjct: 541 QTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQ 600

Query: 601 IWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPA 660
           IWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPA
Sbjct: 601 IWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPA 660

Query: 661 IKTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDA 720
           IKTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDA
Sbjct: 661 IKTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDA 720

Query: 721 RYQQQNPAAVLYQRSKSLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHP 780
           RYQQQNPAAVLYQRSKSLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHP
Sbjct: 721 RYQQQNPAAVLYQRSKSLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHP 780

Query: 781 SPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSY 840
           SPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSY
Sbjct: 781 SPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSY 840

Query: 841 PTVIQQQNATSQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDELIDTHLSWIQNI 900
           PTVIQQQNATSQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDELIDTHLSWIQNI
Sbjct: 841 PTVIQQQNATSQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDELIDTHLSWIQNI 900

Query: 901 L 901
           L
Sbjct: 901 L 901


>gi|27886539 nuclear factor of activated T-cells, cytoplasmic,
           calcineurin-dependent 2 isoform B [Homo sapiens]
          Length = 921

 Score = 1801 bits (4666), Expect = 0.0
 Identities = 878/880 (99%), Positives = 880/880 (100%)

Query: 22  DQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAA 81
           ++EEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAA
Sbjct: 42  NEEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAA 101

Query: 82  KPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGY 141
           KPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGY
Sbjct: 102 KPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGY 161

Query: 142 REPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMS 201
           REPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMS
Sbjct: 162 REPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMS 221

Query: 202 PRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSS 261
           PRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSS
Sbjct: 222 PRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSS 281

Query: 262 HVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGL 321
           HVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGL
Sbjct: 282 HVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGL 341

Query: 322 PRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPL 381
           PRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPL
Sbjct: 342 PRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPL 401

Query: 382 SSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIG 441
           SSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIG
Sbjct: 402 SSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIG 461

Query: 442 TADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKL 501
           TADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKL
Sbjct: 462 TADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKL 521

Query: 502 RNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVE 561
           RNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVE
Sbjct: 522 RNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVE 581

Query: 562 RQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVE 621
           RQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVE
Sbjct: 582 RQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVE 641

Query: 622 IPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLICSPTHGG 681
           IPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLICSPTHGG
Sbjct: 642 IPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLICSPTHGG 701

Query: 682 LGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPS 741
           LGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPS
Sbjct: 702 LGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPS 761

Query: 742 LLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLR 801
           LLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLR
Sbjct: 762 LLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLR 821

Query: 802 CGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKNGPPV 861
           CGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKNGPPV
Sbjct: 822 CGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKNGPPV 881

Query: 862 SDQKEVLPAGVTIKQEQNLDQTYLDDELIDTHLSWIQNIL 901
           SDQKEVLPAGVTIKQEQNLDQTYLDDELIDTHLSWIQNIL
Sbjct: 882 SDQKEVLPAGVTIKQEQNLDQTYLDDELIDTHLSWIQNIL 921


>gi|27886541 nuclear factor of activated T-cells, cytoplasmic,
           calcineurin-dependent 2 isoform C [Homo sapiens]
          Length = 925

 Score = 1773 bits (4592), Expect = 0.0
 Identities = 864/866 (99%), Positives = 866/866 (100%)

Query: 22  DQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAA 81
           ++EEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAA
Sbjct: 42  NEEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAA 101

Query: 82  KPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGY 141
           KPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGY
Sbjct: 102 KPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGY 161

Query: 142 REPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMS 201
           REPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMS
Sbjct: 162 REPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMS 221

Query: 202 PRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSS 261
           PRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSS
Sbjct: 222 PRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSS 281

Query: 262 HVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGL 321
           HVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGL
Sbjct: 282 HVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGL 341

Query: 322 PRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPL 381
           PRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPL
Sbjct: 342 PRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPL 401

Query: 382 SSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIG 441
           SSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIG
Sbjct: 402 SSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIG 461

Query: 442 TADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKL 501
           TADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKL
Sbjct: 462 TADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKL 521

Query: 502 RNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVE 561
           RNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVE
Sbjct: 522 RNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVE 581

Query: 562 RQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVE 621
           RQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVE
Sbjct: 582 RQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVE 641

Query: 622 IPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLICSPTHGG 681
           IPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLICSPTHGG
Sbjct: 642 IPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLICSPTHGG 701

Query: 682 LGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPS 741
           LGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPS
Sbjct: 702 LGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPS 761

Query: 742 LLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLR 801
           LLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLR
Sbjct: 762 LLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLR 821

Query: 802 CGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKNGPPV 861
           CGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKNGPPV
Sbjct: 822 CGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKNGPPV 881

Query: 862 SDQKEVLPAGVTIKQEQNLDQTYLDD 887
           SDQKEVLPAGVTIKQEQNLDQTYLDD
Sbjct: 882 SDQKEVLPAGVTIKQEQNLDQTYLDD 907


>gi|27502386 nuclear factor of activated T-cells, cytosolic
           component 1 isoform C [Homo sapiens]
          Length = 930

 Score =  595 bits (1533), Expect = e-170
 Identities = 407/941 (43%), Positives = 515/941 (54%), Gaps = 133/941 (14%)

Query: 26  PNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQK-FLSAA--K 82
           P AH     P           + L+  +P      + P  +G     GP   FLS+   +
Sbjct: 46  PTAHSTLPAPC----------HNLQTSTPGIIPPADHPSGYGAALDGGPAGYFLSSGHTR 95

Query: 83  PAGASGL-SPRIEITPS----HELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPG 137
           P GA  L SPRIEIT      H   Q    + + D     ++ P          TL +P 
Sbjct: 96  PDGAPALESPRIEITSCLGLYHNNNQFFHDVEVEDVLPSSKRSPSTA-------TLSLPS 148

Query: 138 FEGYREPLCLSPASSGSSAS---------------FISDTFSPYTSPCVSPNNGGPDDLC 182
            E YR+P CLSPASS SS S               + S   SP+ SPCVSP    P++  
Sbjct: 149 LEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGF 208

Query: 183 PQFQNIPAHY-SPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALV 241
           P+         SPR SP  SPR S+ E+S LG  S      SR +SP  KR++S    L 
Sbjct: 209 PRGLGACTLLGSPRHSPSTSPRASVTEESWLGARS------SRPASPCNKRKYS----LN 258

Query: 242 ALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPC----G 297
              P  SP  S +PSP  S  V+  D  S  G      S+ I+ A+N+L TDS      G
Sbjct: 259 GRQPPYSPHHSPTPSPHGSPRVSVTDD-SWLGNTTQYTSSAIVAAINALTTDSSLDLGDG 317

Query: 298 IPPKMWKTSPDPSP------------VSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAP 345
           +P K  KT+ +  P            + + P  A      Y + + +       R+    
Sbjct: 318 VPVKSRKTTLEQPPSVALKVEPVGEDLGSPPPPADFAPEDYSSFQHI-------RKGGFC 370

Query: 346 ESILLVPP---TW--PKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHH 400
           +  L VP     W  PKPL P     +  ++ +LP L+W L S SG YELRIEVQPK HH
Sbjct: 371 DQYLAVPQHPYQWAKPKPLSP-----TSYMSPTLPALDWQLPSHSGPYELRIEVQPKSHH 425

Query: 401 RAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRIT 460
           RAHYETEGSRGAVKA  GGHP+VQLHGY+EN+PL LQ+FIGTAD+R+L+PHAFYQVHRIT
Sbjct: 426 RAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLMLQLFIGTADDRLLRPHAFYQVHRIT 485

Query: 461 GKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNT 520
           GKTV+TTS+E I+ NTKVLEIPL P+N+MRA IDCAGILKLRN+DIELRKGETDIGRKNT
Sbjct: 486 GKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETDIGRKNT 545

Query: 521 RVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTG 580
           RVRLVFRVH+P+ SGR +SLQ ASNPIECSQRSA ELP+VE+Q TDS  V GG++M+L+G
Sbjct: 546 RVRLVFRVHVPQPSGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVVGGKKMVLSG 605

Query: 581 QNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYV 640
            NF  +SKV+F EK  DG  +WEMEA  D+D  +PN L VEIP +RN+ I +PV V+FYV
Sbjct: 606 HNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVHVSFYV 665

Query: 641 INGKRKRSQPQHFTYHP--VPAIKTEPTDEYDPTLICSPTHGGLG--SQPYYPQHPMVAE 696
            NGKRKRSQ Q FTY P  VP IKTEPTD+Y+P   C P   GL    +PYY Q   +  
Sbjct: 666 CNGKRKRSQYQRFTYLPANVPIIKTEPTDDYEPAPTCGPVSQGLSPLPRPYYSQQLAMPP 725

Query: 697 SP-SCLVATMAPCQQFRTGL-SSPDARYQQQNPAAVLYQRS-KSLSPSLLGYQQPALMAA 753
            P SCLVA   PC Q  T + ++P    +  + +   Y +   S     LG  QPA  A 
Sbjct: 726 DPSSCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSPAAYTKGVASPGHCHLGLPQPAGEAP 785

Query: 754 PLSLADAHRSVLVHAGSQGQSSALLHP----SPTNQQASPVIHYS-----------PTNQ 798
             ++ D  R V  H GS GQ    L P    +P +    P + +S           P  Q
Sbjct: 786 --AVQDVPRPVATHPGSPGQPPPALLPQQVSAPPSSSCPPGLEHSLCPSSPSPPLPPATQ 843

Query: 799 QLRCGSHQEFQHIMYCENFA-PGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKN 857
           +  C        +  C     P T RP   P +  +  SP + P ++ + +       ++
Sbjct: 844 EPTC--------LQPCSPACPPATGRPQHLPSTVRRDESPTAGPRLLPEVH-------ED 888

Query: 858 GPPVSDQKEVLPAGVTIKQE-QNLDQTYLDD--ELIDTHLS 895
           G P      + P  VT+K+E + LDQ YLDD  E+I   LS
Sbjct: 889 GSP-----NLAPIPVTVKREPEELDQLYLDDVNEIIRNDLS 924


>gi|19923350 nuclear factor of activated T-cells, cytosolic
           component 1 isoform B [Homo sapiens]
          Length = 825

 Score =  580 bits (1495), Expect = e-165
 Identities = 378/824 (45%), Positives = 469/824 (56%), Gaps = 91/824 (11%)

Query: 16  RIMGSVDQEEPNAHKVASPPSGPAYPDDVLD-------YGLKPYSPLASLSGEPPGRFGE 68
           R  G++   E   +  AS    PA P            + L+  +P      + P  +G 
Sbjct: 32  RAGGTMKSAEEEHYGYASSNVSPALPLPTAHSTLPAPCHNLQTSTPGIIPPADHPSGYGA 91

Query: 69  PDRVGPQK-FLSAA--KPAGASGL-SPRIEITPS----HELIQAVGPLRMRDAGLLVEQP 120
               GP   FLS+   +P GA  L SPRIEIT      H   Q    + + D     ++ 
Sbjct: 92  ALDGGPAGYFLSSGHTRPDGAPALESPRIEITSCLGLYHNNNQFFHDVEVEDVLPSSKRS 151

Query: 121 PLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSAS---------------FISDTFSP 165
           P          TL +P  E YR+P CLSPASS SS S               + S   SP
Sbjct: 152 PSTA-------TLSLPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSP 204

Query: 166 YTSPCVSPNNGGPDDLCPQFQNIPAHY-SPRTSPIMSPRTSLAEDSCLGRHSPVPRPASR 224
           + SPCVSP    P++  P+         SPR SP  SPR S+ E+S LG  S      SR
Sbjct: 205 WQSPCVSPKTTDPEEGFPRGLGACTLLGSPRHSPSTSPRASVTEESWLGARS------SR 258

Query: 225 SSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIM 284
            +SP  KR++S    L    P  SP  S +PSP  S  V+  D  S  G      S+ I+
Sbjct: 259 PASPCNKRKYS----LNGRQPPYSPHHSPTPSPHGSPRVSVTDD-SWLGNTTQYTSSAIV 313

Query: 285 DALNSLATDSPC----GIPPKMWKTSPDPSP------------VSAAPSKAGLPRHIYPA 328
            A+N+L TDS      G+P K  KT+ +  P            + + P  A      Y +
Sbjct: 314 AAINALTTDSSLDLGDGVPVKSRKTTLEQPPSVALKVEPVGEDLGSPPPPADFAPEDYSS 373

Query: 329 VEFLGPCEQGERRNSAPESILLVPP---TW--PKPLVPAIPICSIPVTASLPPLEWPLSS 383
            + +       R+    +  L VP     W  PKPL P     +  ++ +LP L+W L S
Sbjct: 374 FQHI-------RKGGFCDQYLAVPQHPYQWAKPKPLSP-----TSYMSPTLPALDWQLPS 421

Query: 384 QSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTA 443
            SG YELRIEVQPK HHRAHYETEGSRGAVKA  GGHP+VQLHGY+EN+PL LQ+FIGTA
Sbjct: 422 HSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLMLQLFIGTA 481

Query: 444 DERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRN 503
           D+R+L+PHAFYQVHRITGKTV+TTS+E I+ NTKVLEIPL P+N+MRA IDCAGILKLRN
Sbjct: 482 DDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLRN 541

Query: 504 ADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQ 563
           +DIELRKGETDIGRKNTRVRLVFRVH+P+ SGR +SLQ ASNPIECSQRSA ELP+VE+Q
Sbjct: 542 SDIELRKGETDIGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQRSAQELPLVEKQ 601

Query: 564 DTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIP 623
            TDS  V GG++M+L+G NF  +SKV+F EK  DG  +WEMEA  D+D  +PN L VEIP
Sbjct: 602 STDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIP 661

Query: 624 EYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHP--VPAIKTEPTDEYDPTLICSPTHGG 681
            +RN+ I +PV V+FYV NGKRKRSQ Q FTY P  VP IKTEPTD+Y+P   C P   G
Sbjct: 662 PFRNQRITSPVHVSFYVCNGKRKRSQYQRFTYLPANVPIIKTEPTDDYEPAPTCGPVSQG 721

Query: 682 LG--SQPYYPQHPMVAESP-SCLVATMAPCQQFRTGL-SSPDARYQQQNPAAVLYQRS-K 736
           L    +PYY Q   +   P SCLVA   PC Q  T + ++P    +  + +   Y +   
Sbjct: 722 LSPLPRPYYSQQLAMPPDPSSCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSPAAYTKGVA 781

Query: 737 SLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHP 780
           S     LG  QPA  A   ++ D  R V  H GS GQ    L P
Sbjct: 782 SPGHCHLGLPQPAGEAP--AVQDVPRPVATHPGSPGQPPPALLP 823


>gi|27502391 nuclear factor of activated T-cells, cytosolic
           component 1 isoform E [Homo sapiens]
          Length = 812

 Score =  579 bits (1493), Expect = e-165
 Identities = 374/807 (46%), Positives = 462/807 (57%), Gaps = 94/807 (11%)

Query: 26  PNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQK-FLSAA--K 82
           P AH     P           + L+  +P      + P  +G     GP   FLS+   +
Sbjct: 46  PTAHSTLPAPC----------HNLQTSTPGIIPPADHPSGYGAALDGGPAGYFLSSGHTR 95

Query: 83  PAGASGL-SPRIEITPS----HELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPG 137
           P GA  L SPRIEIT      H   Q    + + D     ++ P          TL +P 
Sbjct: 96  PDGAPALESPRIEITSCLGLYHNNNQFFHDVEVEDVLPSSKRSPSTA-------TLSLPS 148

Query: 138 FEGYREPLCLSPASSGSSAS---------------FISDTFSPYTSPCVSPNNGGPDDLC 182
            E YR+P CLSPASS SS S               + S   SP+ SPCVSP    P++  
Sbjct: 149 LEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGF 208

Query: 183 PQFQNIPAHY-SPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALV 241
           P+         SPR SP  SPR S+ E+S LG  S      SR +SP  KR++S    L 
Sbjct: 209 PRGLGACTLLGSPRHSPSTSPRASVTEESWLGARS------SRPASPCNKRKYS----LN 258

Query: 242 ALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPC----G 297
              P  SP  S +PSP  S  V+  D  S  G      S+ I+ A+N+L TDS      G
Sbjct: 259 GRQPPYSPHHSPTPSPHGSPRVSVTDD-SWLGNTTQYTSSAIVAAINALTTDSSLDLGDG 317

Query: 298 IPPKMWKTSPDPSP------------VSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAP 345
           +P K  KT+ +  P            + + P  A      Y + + +       R+    
Sbjct: 318 VPVKSRKTTLEQPPSVALKVEPVGEDLGSPPPPADFAPEDYSSFQHI-------RKGGFC 370

Query: 346 ESILLVPP---TW--PKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHH 400
           +  L VP     W  PKPL P     +  ++ +LP L+W L S SG YELRIEVQPK HH
Sbjct: 371 DQYLAVPQHPYQWAKPKPLSP-----TSYMSPTLPALDWQLPSHSGPYELRIEVQPKSHH 425

Query: 401 RAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRIT 460
           RAHYETEGSRGAVKA  GGHP+VQLHGY+EN+PL LQ+FIGTAD+R+L+PHAFYQVHRIT
Sbjct: 426 RAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLMLQLFIGTADDRLLRPHAFYQVHRIT 485

Query: 461 GKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNT 520
           GKTV+TTS+E I+ NTKVLEIPL P+N+MRA IDCAGILKLRN+DIELRKGETDIGRKNT
Sbjct: 486 GKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETDIGRKNT 545

Query: 521 RVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTG 580
           RVRLVFRVH+P+ SGR +SLQ ASNPIECSQRSA ELP+VE+Q TDS  V GG++M+L+G
Sbjct: 546 RVRLVFRVHVPQPSGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVVGGKKMVLSG 605

Query: 581 QNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYV 640
            NF  +SKV+F EK  DG  +WEMEA  D+D  +PN L VEIP +RN+ I +PV V+FYV
Sbjct: 606 HNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVHVSFYV 665

Query: 641 INGKRKRSQPQHFTYHP--VPAIKTEPTDEYDPTLICSPTHGGLG--SQPYYPQHPMVAE 696
            NGKRKRSQ Q FTY P  VP IKTEPTD+Y+P   C P   GL    +PYY Q   +  
Sbjct: 666 CNGKRKRSQYQRFTYLPANVPIIKTEPTDDYEPAPTCGPVSQGLSPLPRPYYSQQLAMPP 725

Query: 697 SP-SCLVATMAPCQQFRTGL-SSPDARYQQQNPAAVLYQRS-KSLSPSLLGYQQPALMAA 753
            P SCLVA   PC Q  T + ++P    +  + +   Y +   S     LG  QPA  A 
Sbjct: 726 DPSSCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSPAAYTKGVASPGHCHLGLPQPAGEAP 785

Query: 754 PLSLADAHRSVLVHAGSQGQSSALLHP 780
             ++ D  R V  H GS GQ    L P
Sbjct: 786 --AVQDVPRPVATHPGSPGQPPPALLP 810


>gi|27502393 nuclear factor of activated T-cells, cytosolic
           component 1 isoform A [Homo sapiens]
          Length = 716

 Score =  525 bits (1352), Expect = e-149
 Identities = 330/694 (47%), Positives = 408/694 (58%), Gaps = 82/694 (11%)

Query: 16  RIMGSVDQEEPNAHKVASPPSGPAYPDDVLD-------YGLKPYSPLASLSGEPPGRFGE 68
           R  G++   E   +  AS    PA P            + L+  +P      + P  +G 
Sbjct: 32  RAGGTMKSAEEEHYGYASSNVSPALPLPTAHSTLPAPCHNLQTSTPGIIPPADHPSGYGA 91

Query: 69  PDRVGPQK-FLSAA--KPAGASGL-SPRIEITPS----HELIQAVGPLRMRDAGLLVEQP 120
               GP   FLS+   +P GA  L SPRIEIT      H   Q    + + D     ++ 
Sbjct: 92  ALDGGPAGYFLSSGHTRPDGAPALESPRIEITSCLGLYHNNNQFFHDVEVEDVLPSSKRS 151

Query: 121 PLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSAS---------------FISDTFSP 165
           P          TL +P  E YR+P CLSPASS SS S               + S   SP
Sbjct: 152 PSTA-------TLSLPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSP 204

Query: 166 YTSPCVSPNNGGPDDLCPQFQNIPAHY-SPRTSPIMSPRTSLAEDSCLGRHSPVPRPASR 224
           + SPCVSP    P++  P+         SPR SP  SPR S+ E+S LG  S      SR
Sbjct: 205 WQSPCVSPKTTDPEEGFPRGLGACTLLGSPRHSPSTSPRASVTEESWLGARS------SR 258

Query: 225 SSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIM 284
            +SP  KR++S    L    P  SP  S +PSP  S  V+  D  S  G      S+ I+
Sbjct: 259 PASPCNKRKYS----LNGRQPPYSPHHSPTPSPHGSPRVSVTDD-SWLGNTTQYTSSAIV 313

Query: 285 DALNSLATDSPC----GIPPKMWKTSPDPSP------------VSAAPSKAGLPRHIYPA 328
            A+N+L TDS      G+P K  KT+ +  P            + + P  A      Y +
Sbjct: 314 AAINALTTDSSLDLGDGVPVKSRKTTLEQPPSVALKVEPVGEDLGSPPPPADFAPEDYSS 373

Query: 329 VEFLGPCEQGERRNSAPESILLVPP---TW--PKPLVPAIPICSIPVTASLPPLEWPLSS 383
            + +       R+    +  L VP     W  PKPL P     +  ++ +LP L+W L S
Sbjct: 374 FQHI-------RKGGFCDQYLAVPQHPYQWAKPKPLSP-----TSYMSPTLPALDWQLPS 421

Query: 384 QSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTA 443
            SG YELRIEVQPK HHRAHYETEGSRGAVKA  GGHP+VQLHGY+EN+PL LQ+FIGTA
Sbjct: 422 HSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLMLQLFIGTA 481

Query: 444 DERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRN 503
           D+R+L+PHAFYQVHRITGKTV+TTS+E I+ NTKVLEIPL P+N+MRA IDCAGILKLRN
Sbjct: 482 DDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLRN 541

Query: 504 ADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQ 563
           +DIELRKGETDIGRKNTRVRLVFRVH+P+ SGR +SLQ ASNPIECSQRSA ELP+VE+Q
Sbjct: 542 SDIELRKGETDIGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQRSAQELPLVEKQ 601

Query: 564 DTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIP 623
            TDS  V GG++M+L+G NF  +SKV+F EK  DG  +WEMEA  D+D  +PN L VEIP
Sbjct: 602 STDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIP 661

Query: 624 EYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHP 657
            +RN+ I +PV V+FYV NGKRKRSQ Q FTY P
Sbjct: 662 PFRNQRITSPVHVSFYVCNGKRKRSQYQRFTYLP 695


>gi|27886561 nuclear factor of activated T-cells, cytoplasmic,
           calcineurin-dependent 3 isoform 1 [Homo sapiens]
          Length = 1075

 Score =  451 bits (1160), Expect = e-126
 Identities = 317/760 (41%), Positives = 406/760 (53%), Gaps = 84/760 (11%)

Query: 115 LLVEQPPLAGVAASPRFTLPVPGFEGYREP-LCLSPASSGSSASFISDTFS--------- 164
           L +  P    +    R  L +P    YRE  L  SPASS SS S+ SD  S         
Sbjct: 131 LQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYD 190

Query: 165 -----------------PYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLA 207
                            P TSP  SP     ++   Q   +    SPR SP  SPR+S+ 
Sbjct: 191 DVDSELNEAAARFTLGSPLTSPGGSPGGCPGEETWHQQYGLGHSLSPRQSPCHSPRSSVT 250

Query: 208 EDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVA--LPPGASPQRSRSPSPQPSSHVAP 265
           +++ L    P   P+SR +SP  KRRHS AE   A  L P  SP  S   SP+ S     
Sbjct: 251 DENWLSPR-PASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGS---VT 306

Query: 266 QDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGL---- 321
           +D    A    V G + +  A+          IP K  KTS D + +   P K  L    
Sbjct: 307 EDTWLNAS---VHGGSGLGPAVFPFQYCVETDIPLKTRKTSEDQAAI--LPGKLELCSDD 361

Query: 322 PRHIYPAVEFLGPCEQGE----RRNSAPESILLVPP--TWPKPLVPAIPICSIPVTASLP 375
              + PA E       G     +++S  +  L VP   TW KP     PI     T+SLP
Sbjct: 362 QGSLSPARETSIDDGLGSQYPLKKDSCGDQFLSVPSPFTWSKPKPGHTPIFR---TSSLP 418

Query: 376 PLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLG 435
           PL+WPL +  G  EL+IEVQPK HHRAHYETEGSRGAVKA TGGHPVV+L GY E KP+ 
Sbjct: 419 PLDWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNE-KPIN 477

Query: 436 LQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDC 495
           LQ+FIGTAD+R L+PHAFYQVHRITGKTV T S E I+ +TKVLEIPL P+NNM A+IDC
Sbjct: 478 LQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDC 537

Query: 496 AGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAH 555
           AGILKLRN+DIELRKGETDIGRKNTRVRLVFRVHIP+ SG+++SLQ AS P+ECSQRSA 
Sbjct: 538 AGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQ 597

Query: 556 ELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQP 615
           ELP +E+   +SC V GG +M++TG NF  ESK++F EK  DG+  WE+E  + ++K Q 
Sbjct: 598 ELPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQG 657

Query: 616 NMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLIC 675
             + +E+P Y N  +   V+V+FY+ NGKRK+SQ Q FTY PV  +K E  +E D     
Sbjct: 658 AHIVLEVPPYHNPAVTAAVQVHFYLCNGKRKKSQSQRFTYTPV-LMKQEHREEID----- 711

Query: 676 SPTHGGLGSQPYYP-QHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQR 734
                 L S P  P  HP   + PS             +G S       Q++    + Q 
Sbjct: 712 ------LSSVPSLPVPHPAQTQRPSS-----------DSGCSHDSVLSGQRSLICSIPQT 754

Query: 735 SKSLSPSLLGYQQPALMAAPLSLADAHR---SVLVHAGSQGQSSALLHPSPTNQQASPVI 791
             S+  S      P L     S++       S +VH   Q   +  +  S    Q + V+
Sbjct: 755 YASMVTS---SHLPQLQCRDESVSKEQHMIPSPIVHQPFQVTPTPPVGSSYQPMQTN-VV 810

Query: 792 HYSPTNQQLRCGSHQEFQHIMYCENFA-PGTTRPGPPPVS 830
           +  PT   +   S QEF  +++ ++    G    G  P+S
Sbjct: 811 YNGPTCLPINAASSQEFDSVLFQQDATLSGLVNLGCQPLS 850


>gi|27886559 nuclear factor of activated T-cells, cytoplasmic,
           calcineurin-dependent 3 isoform 4 [Homo sapiens]
          Length = 1045

 Score =  451 bits (1160), Expect = e-126
 Identities = 317/760 (41%), Positives = 406/760 (53%), Gaps = 84/760 (11%)

Query: 115 LLVEQPPLAGVAASPRFTLPVPGFEGYREP-LCLSPASSGSSASFISDTFS--------- 164
           L +  P    +    R  L +P    YRE  L  SPASS SS S+ SD  S         
Sbjct: 131 LQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYD 190

Query: 165 -----------------PYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLA 207
                            P TSP  SP     ++   Q   +    SPR SP  SPR+S+ 
Sbjct: 191 DVDSELNEAAARFTLGSPLTSPGGSPGGCPGEETWHQQYGLGHSLSPRQSPCHSPRSSVT 250

Query: 208 EDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVA--LPPGASPQRSRSPSPQPSSHVAP 265
           +++ L    P   P+SR +SP  KRRHS AE   A  L P  SP  S   SP+ S     
Sbjct: 251 DENWLSPR-PASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGS---VT 306

Query: 266 QDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGL---- 321
           +D    A    V G + +  A+          IP K  KTS D + +   P K  L    
Sbjct: 307 EDTWLNAS---VHGGSGLGPAVFPFQYCVETDIPLKTRKTSEDQAAI--LPGKLELCSDD 361

Query: 322 PRHIYPAVEFLGPCEQGE----RRNSAPESILLVPP--TWPKPLVPAIPICSIPVTASLP 375
              + PA E       G     +++S  +  L VP   TW KP     PI     T+SLP
Sbjct: 362 QGSLSPARETSIDDGLGSQYPLKKDSCGDQFLSVPSPFTWSKPKPGHTPIFR---TSSLP 418

Query: 376 PLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLG 435
           PL+WPL +  G  EL+IEVQPK HHRAHYETEGSRGAVKA TGGHPVV+L GY E KP+ 
Sbjct: 419 PLDWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNE-KPIN 477

Query: 436 LQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDC 495
           LQ+FIGTAD+R L+PHAFYQVHRITGKTV T S E I+ +TKVLEIPL P+NNM A+IDC
Sbjct: 478 LQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDC 537

Query: 496 AGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAH 555
           AGILKLRN+DIELRKGETDIGRKNTRVRLVFRVHIP+ SG+++SLQ AS P+ECSQRSA 
Sbjct: 538 AGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQ 597

Query: 556 ELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQP 615
           ELP +E+   +SC V GG +M++TG NF  ESK++F EK  DG+  WE+E  + ++K Q 
Sbjct: 598 ELPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQG 657

Query: 616 NMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLIC 675
             + +E+P Y N  +   V+V+FY+ NGKRK+SQ Q FTY PV  +K E  +E D     
Sbjct: 658 AHIVLEVPPYHNPAVTAAVQVHFYLCNGKRKKSQSQRFTYTPV-LMKQEHREEID----- 711

Query: 676 SPTHGGLGSQPYYP-QHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQR 734
                 L S P  P  HP   + PS             +G S       Q++    + Q 
Sbjct: 712 ------LSSVPSLPVPHPAQTQRPSS-----------DSGCSHDSVLSGQRSLICSIPQT 754

Query: 735 SKSLSPSLLGYQQPALMAAPLSLADAHR---SVLVHAGSQGQSSALLHPSPTNQQASPVI 791
             S+  S      P L     S++       S +VH   Q   +  +  S    Q + V+
Sbjct: 755 YASMVTS---SHLPQLQCRDESVSKEQHMIPSPIVHQPFQVTPTPPVGSSYQPMQTN-VV 810

Query: 792 HYSPTNQQLRCGSHQEFQHIMYCENFA-PGTTRPGPPPVS 830
           +  PT   +   S QEF  +++ ++    G    G  P+S
Sbjct: 811 YNGPTCLPINAASSQEFDSVLFQQDATLSGLVNLGCQPLS 850


>gi|27886555 nuclear factor of activated T-cells, cytoplasmic,
           calcineurin-dependent 3 isoform 3 [Homo sapiens]
          Length = 1065

 Score =  451 bits (1160), Expect = e-126
 Identities = 317/760 (41%), Positives = 406/760 (53%), Gaps = 84/760 (11%)

Query: 115 LLVEQPPLAGVAASPRFTLPVPGFEGYREP-LCLSPASSGSSASFISDTFS--------- 164
           L +  P    +    R  L +P    YRE  L  SPASS SS S+ SD  S         
Sbjct: 131 LQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYD 190

Query: 165 -----------------PYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLA 207
                            P TSP  SP     ++   Q   +    SPR SP  SPR+S+ 
Sbjct: 191 DVDSELNEAAARFTLGSPLTSPGGSPGGCPGEETWHQQYGLGHSLSPRQSPCHSPRSSVT 250

Query: 208 EDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVA--LPPGASPQRSRSPSPQPSSHVAP 265
           +++ L    P   P+SR +SP  KRRHS AE   A  L P  SP  S   SP+ S     
Sbjct: 251 DENWLSPR-PASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGS---VT 306

Query: 266 QDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGL---- 321
           +D    A    V G + +  A+          IP K  KTS D + +   P K  L    
Sbjct: 307 EDTWLNAS---VHGGSGLGPAVFPFQYCVETDIPLKTRKTSEDQAAI--LPGKLELCSDD 361

Query: 322 PRHIYPAVEFLGPCEQGE----RRNSAPESILLVPP--TWPKPLVPAIPICSIPVTASLP 375
              + PA E       G     +++S  +  L VP   TW KP     PI     T+SLP
Sbjct: 362 QGSLSPARETSIDDGLGSQYPLKKDSCGDQFLSVPSPFTWSKPKPGHTPIFR---TSSLP 418

Query: 376 PLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLG 435
           PL+WPL +  G  EL+IEVQPK HHRAHYETEGSRGAVKA TGGHPVV+L GY E KP+ 
Sbjct: 419 PLDWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNE-KPIN 477

Query: 436 LQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDC 495
           LQ+FIGTAD+R L+PHAFYQVHRITGKTV T S E I+ +TKVLEIPL P+NNM A+IDC
Sbjct: 478 LQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDC 537

Query: 496 AGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAH 555
           AGILKLRN+DIELRKGETDIGRKNTRVRLVFRVHIP+ SG+++SLQ AS P+ECSQRSA 
Sbjct: 538 AGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQ 597

Query: 556 ELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQP 615
           ELP +E+   +SC V GG +M++TG NF  ESK++F EK  DG+  WE+E  + ++K Q 
Sbjct: 598 ELPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQG 657

Query: 616 NMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLIC 675
             + +E+P Y N  +   V+V+FY+ NGKRK+SQ Q FTY PV  +K E  +E D     
Sbjct: 658 AHIVLEVPPYHNPAVTAAVQVHFYLCNGKRKKSQSQRFTYTPV-LMKQEHREEID----- 711

Query: 676 SPTHGGLGSQPYYP-QHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQR 734
                 L S P  P  HP   + PS             +G S       Q++    + Q 
Sbjct: 712 ------LSSVPSLPVPHPAQTQRPSS-----------DSGCSHDSVLSGQRSLICSIPQT 754

Query: 735 SKSLSPSLLGYQQPALMAAPLSLADAHR---SVLVHAGSQGQSSALLHPSPTNQQASPVI 791
             S+  S      P L     S++       S +VH   Q   +  +  S    Q + V+
Sbjct: 755 YASMVTS---SHLPQLQCRDESVSKEQHMIPSPIVHQPFQVTPTPPVGSSYQPMQTN-VV 810

Query: 792 HYSPTNQQLRCGSHQEFQHIMYCENFA-PGTTRPGPPPVS 830
           +  PT   +   S QEF  +++ ++    G    G  P+S
Sbjct: 811 YNGPTCLPINAASSQEFDSVLFQQDATLSGLVNLGCQPLS 850


>gi|4758804 nuclear factor of activated T-cells, cytoplasmic,
           calcineurin-dependent 3 isoform 2 [Homo sapiens]
          Length = 1068

 Score =  451 bits (1160), Expect = e-126
 Identities = 317/760 (41%), Positives = 406/760 (53%), Gaps = 84/760 (11%)

Query: 115 LLVEQPPLAGVAASPRFTLPVPGFEGYREP-LCLSPASSGSSASFISDTFS--------- 164
           L +  P    +    R  L +P    YRE  L  SPASS SS S+ SD  S         
Sbjct: 131 LQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYD 190

Query: 165 -----------------PYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLA 207
                            P TSP  SP     ++   Q   +    SPR SP  SPR+S+ 
Sbjct: 191 DVDSELNEAAARFTLGSPLTSPGGSPGGCPGEETWHQQYGLGHSLSPRQSPCHSPRSSVT 250

Query: 208 EDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVA--LPPGASPQRSRSPSPQPSSHVAP 265
           +++ L    P   P+SR +SP  KRRHS AE   A  L P  SP  S   SP+ S     
Sbjct: 251 DENWLSPR-PASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGS---VT 306

Query: 266 QDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGL---- 321
           +D    A    V G + +  A+          IP K  KTS D + +   P K  L    
Sbjct: 307 EDTWLNAS---VHGGSGLGPAVFPFQYCVETDIPLKTRKTSEDQAAI--LPGKLELCSDD 361

Query: 322 PRHIYPAVEFLGPCEQGE----RRNSAPESILLVPP--TWPKPLVPAIPICSIPVTASLP 375
              + PA E       G     +++S  +  L VP   TW KP     PI     T+SLP
Sbjct: 362 QGSLSPARETSIDDGLGSQYPLKKDSCGDQFLSVPSPFTWSKPKPGHTPIFR---TSSLP 418

Query: 376 PLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLG 435
           PL+WPL +  G  EL+IEVQPK HHRAHYETEGSRGAVKA TGGHPVV+L GY E KP+ 
Sbjct: 419 PLDWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNE-KPIN 477

Query: 436 LQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDC 495
           LQ+FIGTAD+R L+PHAFYQVHRITGKTV T S E I+ +TKVLEIPL P+NNM A+IDC
Sbjct: 478 LQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDC 537

Query: 496 AGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAH 555
           AGILKLRN+DIELRKGETDIGRKNTRVRLVFRVHIP+ SG+++SLQ AS P+ECSQRSA 
Sbjct: 538 AGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQ 597

Query: 556 ELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQP 615
           ELP +E+   +SC V GG +M++TG NF  ESK++F EK  DG+  WE+E  + ++K Q 
Sbjct: 598 ELPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQG 657

Query: 616 NMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLIC 675
             + +E+P Y N  +   V+V+FY+ NGKRK+SQ Q FTY PV  +K E  +E D     
Sbjct: 658 AHIVLEVPPYHNPAVTAAVQVHFYLCNGKRKKSQSQRFTYTPV-LMKQEHREEID----- 711

Query: 676 SPTHGGLGSQPYYP-QHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQR 734
                 L S P  P  HP   + PS             +G S       Q++    + Q 
Sbjct: 712 ------LSSVPSLPVPHPAQTQRPSS-----------DSGCSHDSVLSGQRSLICSIPQT 754

Query: 735 SKSLSPSLLGYQQPALMAAPLSLADAHR---SVLVHAGSQGQSSALLHPSPTNQQASPVI 791
             S+  S      P L     S++       S +VH   Q   +  +  S    Q + V+
Sbjct: 755 YASMVTS---SHLPQLQCRDESVSKEQHMIPSPIVHQPFQVTPTPPVGSSYQPMQTN-VV 810

Query: 792 HYSPTNQQLRCGSHQEFQHIMYCENFA-PGTTRPGPPPVS 830
           +  PT   +   S QEF  +++ ++    G    G  P+S
Sbjct: 811 YNGPTCLPINAASSQEFDSVLFQQDATLSGLVNLGCQPLS 850


>gi|209862845 nuclear factor of activated T-cells, cytoplasmic,
           calcineurin-dependent 4 isoform 1 [Homo sapiens]
          Length = 964

 Score =  426 bits (1096), Expect = e-119
 Identities = 306/698 (43%), Positives = 366/698 (52%), Gaps = 94/698 (13%)

Query: 63  PGRFGEPDRVGPQKFLSAAKPA----------GASGLSP-RIEITPSHELIQAVGPLRMR 111
           PG    P R  P      ++PA          GA G    R+   PS   I ++ P    
Sbjct: 132 PGMHSPPPRPAPSPGTWESQPARSVRLGGPGGGAGGAGGGRVLECPSIR-ITSISPTPEP 190

Query: 112 DAGLLVEQPPLAGVAASPRFTLPVPGFEGYREP--------LCLSPASSG-SSASFISDT 162
            A L  E  P A    SPR   P  GF GYRE            SP SS  SS SF SD 
Sbjct: 191 PAAL--EDNPDAWGDGSPRDYPPPEGFGGYREAGGQGGGAFFSPSPGSSSLSSWSFFSDA 248

Query: 163 F--------------------------SPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRT 196
                                      SP  SP  SP    P+D    +   P    P  
Sbjct: 249 SDEAALYAACDEVESELNEAASRFGLGSPLPSPRASPRPWTPEDPWSLYGPSPGGRGP-- 306

Query: 197 SPIMSPRTSLAEDSCLGRHSPVPRPAS-RSSSPGAKRRHSCAEALVALPPGASPQRSRSP 255
                      EDS L   +P P PAS R +SP  KRR+S +      P  ASP  SR  
Sbjct: 307 -----------EDSWLLLSAPGPTPASPRPASPCGKRRYSSS----GTPSSASPALSRRG 351

Query: 256 SPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPS---PV 312
           S        P     P    P  GS    D + +   +S   IP K  +TS + +   P 
Sbjct: 352 SLGEEGSEPPPPPPLPLARDP--GSPGPFDYVGAPPAES---IPQKTRRTSSEQAVALPR 406

Query: 313 SAAPSKAG--LPRHIYPAVEFLGPCEQGERRNSAPESILLVPP--TWPKPLVPA-IPICS 367
           S  P+     LP     A E + P   G R+  A    L VP    W K  +    PI  
Sbjct: 407 SEEPASCNGKLP---LGAEESVAP-PGGSRKEVAGMDYLAVPSPLAWSKARIGGHSPIFR 462

Query: 368 IPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHG 427
              T++LPPL+WPL SQ    ELRIEVQP+ HHRAHYETEGSRGAVKA  GGHPVV+L G
Sbjct: 463 ---TSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHPVVKLLG 519

Query: 428 YMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKN 487
           Y E KPL LQ+FIGTADER L+PHAFYQVHRITGK V T SYE +V  TKVLE+ L P+N
Sbjct: 520 YSE-KPLTLQMFIGTADERNLRPHAFYQVHRITGKMVATASYEAVVSGTKVLEMTLLPEN 578

Query: 488 NMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPI 547
           NM A IDCAGILKLRN+DIELRKGETDIGRKNTRVRLVFRVH+P+  G++VS+Q AS PI
Sbjct: 579 NMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGGKVVSVQAASVPI 638

Query: 548 ECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEAT 607
           ECSQRSA ELP VE     +C V GG++++LTG NF  +SKVVF E+  DG+  WE EAT
Sbjct: 639 ECSQRSAQELPQVEAYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGPDGKLQWEEEAT 698

Query: 608 VDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTD 667
           V++ +S    L + +PEY NK +  PV+V FYV NG+RKRS  Q F + PV   K EP  
Sbjct: 699 VNRLQSNEVTLTLTVPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFRFLPV-ICKEEPLP 757

Query: 668 EYD----PTLICSPTHGGLGSQPYYPQHPMVA-ESPSC 700
           +      P+   +P    +   P  P +P    E P+C
Sbjct: 758 DSSLRGFPSASATPFGTDMDFSPPRPPYPSYPHEDPAC 795


>gi|27886563 nuclear factor of activated T-cells, cytoplasmic,
           calcineurin-dependent 4 isoform 2 [Homo sapiens]
          Length = 902

 Score =  426 bits (1096), Expect = e-119
 Identities = 306/698 (43%), Positives = 366/698 (52%), Gaps = 94/698 (13%)

Query: 63  PGRFGEPDRVGPQKFLSAAKPA----------GASGLSP-RIEITPSHELIQAVGPLRMR 111
           PG    P R  P      ++PA          GA G    R+   PS   I ++ P    
Sbjct: 69  PGMHSPPPRPAPSPGTWESQPARSVRLGGPGGGAGGAGGGRVLECPSIR-ITSISPTPEP 127

Query: 112 DAGLLVEQPPLAGVAASPRFTLPVPGFEGYREP--------LCLSPASSG-SSASFISDT 162
            A L  E  P A    SPR   P  GF GYRE            SP SS  SS SF SD 
Sbjct: 128 PAAL--EDNPDAWGDGSPRDYPPPEGFGGYREAGGQGGGAFFSPSPGSSSLSSWSFFSDA 185

Query: 163 F--------------------------SPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRT 196
                                      SP  SP  SP    P+D    +   P    P  
Sbjct: 186 SDEAALYAACDEVESELNEAASRFGLGSPLPSPRASPRPWTPEDPWSLYGPSPGGRGP-- 243

Query: 197 SPIMSPRTSLAEDSCLGRHSPVPRPAS-RSSSPGAKRRHSCAEALVALPPGASPQRSRSP 255
                      EDS L   +P P PAS R +SP  KRR+S +      P  ASP  SR  
Sbjct: 244 -----------EDSWLLLSAPGPTPASPRPASPCGKRRYSSS----GTPSSASPALSRRG 288

Query: 256 SPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPS---PV 312
           S        P     P    P  GS    D + +   +S   IP K  +TS + +   P 
Sbjct: 289 SLGEEGSEPPPPPPLPLARDP--GSPGPFDYVGAPPAES---IPQKTRRTSSEQAVALPR 343

Query: 313 SAAPSKAG--LPRHIYPAVEFLGPCEQGERRNSAPESILLVPP--TWPKPLVPA-IPICS 367
           S  P+     LP     A E + P   G R+  A    L VP    W K  +    PI  
Sbjct: 344 SEEPASCNGKLP---LGAEESVAP-PGGSRKEVAGMDYLAVPSPLAWSKARIGGHSPIFR 399

Query: 368 IPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHG 427
              T++LPPL+WPL SQ    ELRIEVQP+ HHRAHYETEGSRGAVKA  GGHPVV+L G
Sbjct: 400 ---TSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHPVVKLLG 456

Query: 428 YMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKN 487
           Y E KPL LQ+FIGTADER L+PHAFYQVHRITGK V T SYE +V  TKVLE+ L P+N
Sbjct: 457 YSE-KPLTLQMFIGTADERNLRPHAFYQVHRITGKMVATASYEAVVSGTKVLEMTLLPEN 515

Query: 488 NMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPI 547
           NM A IDCAGILKLRN+DIELRKGETDIGRKNTRVRLVFRVH+P+  G++VS+Q AS PI
Sbjct: 516 NMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGGKVVSVQAASVPI 575

Query: 548 ECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEAT 607
           ECSQRSA ELP VE     +C V GG++++LTG NF  +SKVVF E+  DG+  WE EAT
Sbjct: 576 ECSQRSAQELPQVEAYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGPDGKLQWEEEAT 635

Query: 608 VDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTD 667
           V++ +S    L + +PEY NK +  PV+V FYV NG+RKRS  Q F + PV   K EP  
Sbjct: 636 VNRLQSNEVTLTLTVPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFRFLPV-ICKEEPLP 694

Query: 668 EYD----PTLICSPTHGGLGSQPYYPQHPMVA-ESPSC 700
           +      P+   +P    +   P  P +P    E P+C
Sbjct: 695 DSSLRGFPSASATPFGTDMDFSPPRPPYPSYPHEDPAC 732


>gi|27502388 nuclear factor of activated T-cells, cytosolic
           component 1 isoform D [Homo sapiens]
          Length = 353

 Score =  387 bits (993), Expect = e-107
 Identities = 208/352 (59%), Positives = 249/352 (70%), Gaps = 9/352 (2%)

Query: 436 LQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDC 495
           LQ+FIGTAD+R+L+PHAFYQVHRITGKTV+TTS+E I+ NTKVLEIPL P+N+MRA IDC
Sbjct: 2   LQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDC 61

Query: 496 AGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAH 555
           AGILKLRN+DIELRKGETDIGRKNTRVRLVFRVH+P+ SGR +SLQ ASNPIECSQRSA 
Sbjct: 62  AGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQRSAQ 121

Query: 556 ELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQP 615
           ELP+VE+Q TDS  V GG++M+L+G NF  +SKV+F EK  DG  +WEMEA  D+D  +P
Sbjct: 122 ELPLVEKQSTDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKP 181

Query: 616 NMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHP--VPAIKTEPTDEYDPTL 673
           N L VEIP +RN+ I +PV V+FYV NGKRKRSQ Q FTY P  VP IKTEPTD+Y+P  
Sbjct: 182 NSLVVEIPPFRNQRITSPVHVSFYVCNGKRKRSQYQRFTYLPANVPIIKTEPTDDYEPAP 241

Query: 674 ICSPTHGGLG--SQPYYPQHPMVAESP-SCLVATMAPCQQFRTGL-SSPDARYQQQNPAA 729
            C P   GL    +PYY Q   +   P SCLVA   PC Q  T + ++P    +  + + 
Sbjct: 242 TCGPVSQGLSPLPRPYYSQQLAMPPDPSSCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSP 301

Query: 730 VLYQRS-KSLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHP 780
             Y +   S     LG  QPA  A   ++ D  R V  H GS GQ    L P
Sbjct: 302 AAYTKGVASPGHCHLGLPQPAGEAP--AVQDVPRPVATHPGSPGQPPPALLP 351


>gi|27886520 nuclear factor of activated T-cells 5 isoform a [Homo
           sapiens]
          Length = 1455

 Score =  221 bits (563), Expect = 2e-57
 Identities = 123/284 (43%), Positives = 173/284 (60%), Gaps = 10/284 (3%)

Query: 378 EWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTG-GHPVVQLHGYMENKPLGL 436
           ++P+ S+    EL+I VQP+  HRA Y TEGSRG+VK  T  G P V+L G+  N+P+ L
Sbjct: 196 QYPVKSEGK--ELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGH--NEPVVL 251

Query: 437 QIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCA 496
           Q+F+G    R+ KPH FYQ  R+TG+  T      I G T V+E+ L+P NNM   +DC 
Sbjct: 252 QVFVGNDSGRV-KPHGFYQACRVTGRNTTPCKEVDIEGTT-VIEVGLDPSNNMTLAVDCV 309

Query: 497 GILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHE 556
           GILKLRNAD+E R G     +K+TR RLVFRV+I    G  ++LQT S+PI C+Q +   
Sbjct: 310 GILKLRNADVEARIGIAGSKKKSTRARLVFRVNIMRKDGSTLTLQTPSSPILCTQPAG-- 367

Query: 557 LPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPN 616
           +P + ++   SC V G +++ L G+NF   +KV+F E  +D +  W+ EA +D +    N
Sbjct: 368 VPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSD-ENSWKSEAEIDMELFHQN 426

Query: 617 MLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPA 660
            L V++P Y ++HI  PV V  YV+    +    Q FTY P PA
Sbjct: 427 HLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPA 470


>gi|5729945 nuclear factor of activated T-cells 5 isoform c [Homo
           sapiens]
          Length = 1531

 Score =  221 bits (563), Expect = 2e-57
 Identities = 123/284 (43%), Positives = 173/284 (60%), Gaps = 10/284 (3%)

Query: 378 EWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTG-GHPVVQLHGYMENKPLGL 436
           ++P+ S+    EL+I VQP+  HRA Y TEGSRG+VK  T  G P V+L G+  N+P+ L
Sbjct: 272 QYPVKSEGK--ELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGH--NEPVVL 327

Query: 437 QIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCA 496
           Q+F+G    R+ KPH FYQ  R+TG+  T      I G T V+E+ L+P NNM   +DC 
Sbjct: 328 QVFVGNDSGRV-KPHGFYQACRVTGRNTTPCKEVDIEGTT-VIEVGLDPSNNMTLAVDCV 385

Query: 497 GILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHE 556
           GILKLRNAD+E R G     +K+TR RLVFRV+I    G  ++LQT S+PI C+Q +   
Sbjct: 386 GILKLRNADVEARIGIAGSKKKSTRARLVFRVNIMRKDGSTLTLQTPSSPILCTQPAG-- 443

Query: 557 LPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPN 616
           +P + ++   SC V G +++ L G+NF   +KV+F E  +D +  W+ EA +D +    N
Sbjct: 444 VPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSD-ENSWKSEAEIDMELFHQN 502

Query: 617 MLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPA 660
            L V++P Y ++HI  PV V  YV+    +    Q FTY P PA
Sbjct: 503 HLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPA 546


>gi|164419746 nuclear factor of activated T-cells 5 isoform d [Homo
           sapiens]
          Length = 1548

 Score =  221 bits (563), Expect = 2e-57
 Identities = 123/284 (43%), Positives = 173/284 (60%), Gaps = 10/284 (3%)

Query: 378 EWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTG-GHPVVQLHGYMENKPLGL 436
           ++P+ S+    EL+I VQP+  HRA Y TEGSRG+VK  T  G P V+L G+  N+P+ L
Sbjct: 290 QYPVKSEGK--ELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGH--NEPVVL 345

Query: 437 QIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCA 496
           Q+F+G    R+ KPH FYQ  R+TG+  T      I G T V+E+ L+P NNM   +DC 
Sbjct: 346 QVFVGNDSGRV-KPHGFYQACRVTGRNTTPCKEVDIEGTT-VIEVGLDPSNNMTLAVDCV 403

Query: 497 GILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHE 556
           GILKLRNAD+E R G     +K+TR RLVFRV+I    G  ++LQT S+PI C+Q +   
Sbjct: 404 GILKLRNADVEARIGIAGSKKKSTRARLVFRVNIMRKDGSTLTLQTPSSPILCTQPAG-- 461

Query: 557 LPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPN 616
           +P + ++   SC V G +++ L G+NF   +KV+F E  +D +  W+ EA +D +    N
Sbjct: 462 VPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSD-ENSWKSEAEIDMELFHQN 520

Query: 617 MLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPA 660
            L V++P Y ++HI  PV V  YV+    +    Q FTY P PA
Sbjct: 521 HLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPA 564


>gi|164419744 nuclear factor of activated T-cells 5 isoform b [Homo
           sapiens]
          Length = 1549

 Score =  221 bits (563), Expect = 2e-57
 Identities = 123/284 (43%), Positives = 173/284 (60%), Gaps = 10/284 (3%)

Query: 378 EWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTG-GHPVVQLHGYMENKPLGL 436
           ++P+ S+    EL+I VQP+  HRA Y TEGSRG+VK  T  G P V+L G+  N+P+ L
Sbjct: 290 QYPVKSEGK--ELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGH--NEPVVL 345

Query: 437 QIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCA 496
           Q+F+G    R+ KPH FYQ  R+TG+  T      I G T V+E+ L+P NNM   +DC 
Sbjct: 346 QVFVGNDSGRV-KPHGFYQACRVTGRNTTPCKEVDIEGTT-VIEVGLDPSNNMTLAVDCV 403

Query: 497 GILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHE 556
           GILKLRNAD+E R G     +K+TR RLVFRV+I    G  ++LQT S+PI C+Q +   
Sbjct: 404 GILKLRNADVEARIGIAGSKKKSTRARLVFRVNIMRKDGSTLTLQTPSSPILCTQPAG-- 461

Query: 557 LPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPN 616
           +P + ++   SC V G +++ L G+NF   +KV+F E  +D +  W+ EA +D +    N
Sbjct: 462 VPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSD-ENSWKSEAEIDMELFHQN 520

Query: 617 MLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPA 660
            L V++P Y ++HI  PV V  YV+    +    Q FTY P PA
Sbjct: 521 HLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPA 564


>gi|27886524 nuclear factor of activated T-cells 5 isoform a [Homo
           sapiens]
          Length = 1455

 Score =  221 bits (563), Expect = 2e-57
 Identities = 123/284 (43%), Positives = 173/284 (60%), Gaps = 10/284 (3%)

Query: 378 EWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTG-GHPVVQLHGYMENKPLGL 436
           ++P+ S+    EL+I VQP+  HRA Y TEGSRG+VK  T  G P V+L G+  N+P+ L
Sbjct: 196 QYPVKSEGK--ELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGH--NEPVVL 251

Query: 437 QIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCA 496
           Q+F+G    R+ KPH FYQ  R+TG+  T      I G T V+E+ L+P NNM   +DC 
Sbjct: 252 QVFVGNDSGRV-KPHGFYQACRVTGRNTTPCKEVDIEGTT-VIEVGLDPSNNMTLAVDCV 309

Query: 497 GILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHE 556
           GILKLRNAD+E R G     +K+TR RLVFRV+I    G  ++LQT S+PI C+Q +   
Sbjct: 310 GILKLRNADVEARIGIAGSKKKSTRARLVFRVNIMRKDGSTLTLQTPSSPILCTQPAG-- 367

Query: 557 LPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPN 616
           +P + ++   SC V G +++ L G+NF   +KV+F E  +D +  W+ EA +D +    N
Sbjct: 368 VPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSD-ENSWKSEAEIDMELFHQN 426

Query: 617 MLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPA 660
            L V++P Y ++HI  PV V  YV+    +    Q FTY P PA
Sbjct: 427 HLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPA 470


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 98/373 (26%), Positives = 130/373 (34%), Gaps = 62/373 (16%)

Query: 12  CHPLR----IMGSVDQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFG 67
           CH  +    I    +Q  P   + + P  G    D+       P +   +  G+P G   
Sbjct: 349 CHKAQGGQTIRSVAEQHTPVCSRFSPPEPGDTPTDE-------PDALYVACQGQPKGGHV 401

Query: 68  ---EPDRVGPQKFLSAAKPAGASG--LSPRIEITPSHELI----QAVGPLRMRDAGLLVE 118
              +P   GP +    AKP G +G  L P++E   + E+         PL          
Sbjct: 402 TSMQPKEPGPLQ--CEAKPLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTS 459

Query: 119 QPPLAGVAASPRFTLP---VPGFEGYREPLCLSPASSGSSASFIS-----DTFSPYTSPC 170
            PP A   + P   LP   +P       PL  SP S     S +S       FSP     
Sbjct: 460 PPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESP 519

Query: 171 VSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGA 230
           +SP    P    P  +  P    P  SP+  P     E+S L   SP P     S  P A
Sbjct: 520 LSPPEESPPS--PALET-PLSPPPEASPLSPP----FEESPL---SPPPEELPTSPPPEA 569

Query: 231 KRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSL 290
            R     E     PP   P+ S    P  +S + P    SP   PP              
Sbjct: 570 SRLSPPPEESPMSPP---PEESPMSPPPEASRLFPPFEESPLSPPP-------------- 612

Query: 291 ATDSPCGIPPKMWKTSPDP--SPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESI 348
             +SP   PP+  + SP P  SP+S  P ++  P    P V  L P     R +  PE  
Sbjct: 613 -EESPLSPPPEASRLSPPPEDSPMSPPPEES--PMSPPPEVSRLSPLPVVSRLSPPPEES 669

Query: 349 LLVPPTWPKPLVP 361
            L PP    P  P
Sbjct: 670 PLSPPPEESPTSP 682



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 100/394 (25%), Positives = 126/394 (31%), Gaps = 91/394 (23%)

Query: 26   PNAHKVASPPSGPAYPDDVL---DYGLKPYSPLAS-LSGEPPGRFGEPDRVGPQKFLSAA 81
            PN   V SP SG       L   D    P +P AS +  + PG    P    P + L+ +
Sbjct: 2302 PNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPS 2361

Query: 82   KPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGY 141
             P+      P     P      A  PL  R      + PP     A P  +LP       
Sbjct: 2362 PPSHPDIFRPGSYTDP-----YAQPPLTPRP-----QPPPPESCCALPPRSLP------- 2404

Query: 142  REPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQN-------------- 187
             +P    PAS  S +S    + SP T   +S     P  + P+FQ+              
Sbjct: 2405 SDPFSRVPASPQSQSS----SQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSR 2460

Query: 188  ---IPAHYSPRTSP--IMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVA 242
                P H  PR  P  +     SLA  S      P   PA  +    AK           
Sbjct: 2461 DPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAK----------- 2509

Query: 243  LPPGASPQRSRSP-------SPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSP 295
            +P G  P   RSP       +P P     PQ  G P+  PPV                 P
Sbjct: 2510 VPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPV---------------PQP 2554

Query: 296  CGIPPKMWKTSPDPSPVSAAPSKAG---LPRHIYPAVEFLGPCEQGERRNSAPESILLVP 352
               PP    +   P P    P          + +P+   LGP        S  ES  L P
Sbjct: 2555 GLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSS-----GSTGESYGLSP 2609

Query: 353  PTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSG 386
               P  L P  P        SLP L    S +SG
Sbjct: 2610 LRPPSVLPPPAP------DGSLPYLSHGASQRSG 2637



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 118/465 (25%), Positives = 157/465 (33%), Gaps = 113/465 (24%)

Query: 23  QEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAK 82
           +E P +    SPPS PA     L+  L P    + LS  PP  F E     P + L  + 
Sbjct: 516 EESPLSPPEESPPS-PA-----LETPLSPPPEASPLS--PP--FEESPLSPPPEELPTSP 565

Query: 83  PAGASGLSPRIE------------ITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPR 130
           P  AS LSP  E            ++P  E  +   P          E+ PL+    + R
Sbjct: 566 PPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASR 625

Query: 131 FTLPVPGFEGYREPLCLSPASSGSSASFISD-------TFSPYTSPCVSPNNGGPDDLCP 183
            + P P       P   SP S     S +S        +  P  SP   P    P    P
Sbjct: 626 LS-PPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPP 684

Query: 184 QFQNI--PAHYSPRTSPIM-SPRTSLAEDSCLG---RHSPV------------------- 218
           +   +  P   SP + P   SP +   EDS +      SP+                   
Sbjct: 685 EASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLS 744

Query: 219 ---------PRPASRSSSPGAKRRHSCAE----ALVALP--PGASPQRSRSP--SPQPSS 261
                    PRP     SP A+  H   +     L A+P  P  SPQ +  P  SPQP  
Sbjct: 745 PRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQ-AEGPHLSPQPEE 803

Query: 262 -HVAPQD---HGSPAGYPPVAGSAVIMDALNSLATDSPCGIP--------PKMWKTSPDP 309
            H++PQ    H SP    P          L S  ++ PC  P        P++ K    P
Sbjct: 804 LHLSPQTEEPHLSPVPEEPCLSPQPEESHL-SPQSEEPCLSPRPEESHLSPELEKPPLSP 862

Query: 310 SPVSA------APSKAGLPRHIYPAVEFLGPC-------EQGERRNSA-PESI------- 348
            P          P+   LP    P    L P        E GE   S  PE +       
Sbjct: 863 RPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGE 922

Query: 349 ------LLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGS 387
                 L+ P   P PL P I   + P  + L  LE+P  ++  S
Sbjct: 923 PSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDS 967



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 107/431 (24%), Positives = 151/431 (35%), Gaps = 98/431 (22%)

Query: 23   QEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAK 82
            ++ P +      P+ P   D ++   L+  SPL  L  EP      P   GP       +
Sbjct: 694  EDSPTSPPPEDSPASPPPEDSLMSLPLEE-SPLLPLPEEPQLC---PRSEGPHLSPRPEE 749

Query: 83   PAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPG--FEG 140
            P     LSPR E    H   QA  P          E+P L  V   P  +    G     
Sbjct: 750  PH----LSPRPE--EPHLSPQAEEPHLSPQP----EEPCLCAVPEEPHLSPQAEGPHLSP 799

Query: 141  YREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTS-PI 199
              E L LSP            T  P+ SP        P++ C   Q   +H SP++  P 
Sbjct: 800  QPEELHLSP-----------QTEEPHLSPV-------PEEPCLSPQPEESHLSPQSEEPC 841

Query: 200  MSPRTSLAEDSCLGRHSPV-PRPASRSSSPGAKRRHSCAEALVALPPGASPQRSR----- 253
            +SPR   +  S      P+ PRP      PG   +    E L   PP   P  S      
Sbjct: 842  LSPRPEESHLSPELEKPPLSPRPEKPPEEPG---QCPAPEELPLFPPPGEPSLSPLLGEP 898

Query: 254  -------------------SPSPQPS--SHVAPQDHGSP-------AGYPPVA------- 278
                               SPS +PS    + P D   P       A  PP         
Sbjct: 899  ALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELE 958

Query: 279  ---GSAVIMDALNSLAT---DSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPA---- 328
               G+    D  + LA    ++P   PP+   T P+P P    P   G P  + PA    
Sbjct: 959  YPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSP--VGPASPIL 1016

Query: 329  VEFLGP-CEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGS 387
            +E L P C    + +  P++    PP+   P  PA+P+ S+P   S       +S ++  
Sbjct: 1017 MEPLPPQCSPLLQHSLVPQN---SPPSQCSP--PALPL-SVPSPLSPIGKVVGVSDEAEL 1070

Query: 388  YELRIEVQPKP 398
            +E+  E   +P
Sbjct: 1071 HEMETEKVSEP 1081


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 91/377 (24%), Positives = 130/377 (34%), Gaps = 51/377 (13%)

Query: 19   GSVDQEEP--NAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQK 76
            GS   + P  N     SP      P++ L +     SP  + S  PP   G P       
Sbjct: 813  GSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTP----- 867

Query: 77   FLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVP 136
              SA  P    G++   + TP+  ++    P          + P L+  ++SP+     P
Sbjct: 868  --SAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATP 925

Query: 137  GFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNN--GGPDDLCPQFQNIPAHYSP 194
              +G    +  SP+  G+            T P  +P +  GGP    P++   P   +P
Sbjct: 926  APKG----IPASPSPKGAP-----------TPPAATPPSPKGGPATPSPKWAPTPPAATP 970

Query: 195  RTSPIMSPRTSLAEDSCLGRHS-PVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSR 253
                  SP+   A  S  G  + P   P S    P               PP      + 
Sbjct: 971  -----PSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAA 1025

Query: 254  SPSPQ----PSSHVAPQDHGSPAGYP-----PVAGSAVIMDALNSLATDSPCGIPPKMWK 304
            +P P+    P +   P   GSPA  P     P   +A +       AT S  G P     
Sbjct: 1026 TPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAA 1085

Query: 305  TSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQG----ERRNSAPESILLVPPTWPKPLV 360
            T P P    A PS  G P  + PA     P  +G         AP +    PP+ PK  +
Sbjct: 1086 TPPSPKGGPATPSPKGAP--MPPAA--TPPSPKGGLATPPHKGAPTTPAATPPS-PKGGL 1140

Query: 361  PAIPICSIPVT-ASLPP 376
               P    P T A+ PP
Sbjct: 1141 ATPPPKGAPTTPAATPP 1157



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 94/372 (25%), Positives = 126/372 (33%), Gaps = 47/372 (12%)

Query: 26   PNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAG 85
            P A    SP  GPA P         P  P A+    PP   G P    P+    A  P  
Sbjct: 942  PPAATPPSPKGGPATPSPKW----APTPPAAT----PPSPKGGPATPSPK---GAPTPPA 990

Query: 86   ASGLSPRI-EITPSHE---LIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGY 141
            A+  SP+    TPS +      AV P   + +      P   G +  P  T P P     
Sbjct: 991  ATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPK--GASTPPAATPPSP----- 1043

Query: 142  REPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLC---PQFQNIPAHYSPRTSP 198
            +     +P   G+  +  +   SP   P      G P       P  +  PA  SP+ +P
Sbjct: 1044 KGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAP 1103

Query: 199  IMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQ 258
            +    T  +    L        P + +++P + +       L   PP  +P    +  P 
Sbjct: 1104 MPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKG-----GLATPPPKGAPTTPAATPPS 1158

Query: 259  PSSHVA-PQDHGSP---AGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSA 314
            P   +A P   G+P   A  PP             LAT SP G P     T P P    A
Sbjct: 1159 PKGGLATPPPKGAPTTPAATPP--------SPKGGLATPSPKGAPTTPAATPPSPKGGLA 1210

Query: 315  APSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASL 374
             PS  G P    PA     P  +G     +P+     P   P P     P    P  A  
Sbjct: 1211 TPSPKGAP--TTPAA--TPPSPKGGLATPSPKGAPTTPAATP-PSPKGGPATPPPKGAPT 1265

Query: 375  PPLEWPLSSQSG 386
            PP   P S + G
Sbjct: 1266 PPAATPPSLKGG 1277



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 86/349 (24%), Positives = 123/349 (35%), Gaps = 50/349 (14%)

Query: 83   PAGASGLSPRI-EITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGY 141
            P     L+P I +  PS  L  A  P   +    +     LA VA+SP+   P       
Sbjct: 720  PLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPK-ECPT------ 772

Query: 142  REPLCLSPASSGSSASFISDTFSPY--------TSPCVSPNNGGPDDLCPQFQNIPAHYS 193
             +    + ASS  + ++++D+ SP           P     + GPD       N+ +  S
Sbjct: 773  EDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDT---PIGNLSSPVS 829

Query: 194  PRTSPIMSPRTSLA----EDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASP 249
            P  +  + P  SL+    +DS    HSP P     + +P A    S     V LPP  +P
Sbjct: 830  PVEASFL-PENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKG--VTLPPKETP 886

Query: 250  QRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDP 309
              S    P P           PA   P    A+ M + +           PK  + +P P
Sbjct: 887  TPSVVNLPFPKE--------GPATPAPKQAPALSMTSSS-----------PKKARATPAP 927

Query: 310  SPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSIP 369
              + A+PS  G P    PA     P  +G     +P+     PP    P     P    P
Sbjct: 928  KGIPASPSPKGAPTP--PAAT--PPSPKGGPATPSPKWAP-TPPAATPPSPKGGPATPSP 982

Query: 370  VTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTG 418
              A  PP   P S + G      +  P P        +GS  A   P G
Sbjct: 983  KGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKG 1031



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 48/199 (24%), Positives = 74/199 (37%), Gaps = 23/199 (11%)

Query: 178 PDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCA 237
           P    P  Q  P   + + SP  SP T  +        +P+  P  +SSS  A    +  
Sbjct: 46  PPPCSPAPQQCPLSAANQASPFPSPSTIAS--------TPLEVPFPQSSSGTALPLGTAP 97

Query: 238 EALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCG 297
           EA   LP    P  S +     S  +AP   G+P+   P+A     + AL   +      
Sbjct: 98  EAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSSSAPLA-----LVALAPHSVQKSSA 152

Query: 298 IPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPK 357
            PP +       SP S A +++G    +      + P E     N  P  ++  P   P 
Sbjct: 153 FPPNLL-----TSPPSVAVAESG---SVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPS 204

Query: 358 P--LVPAIPICSIPVTASL 374
           P  +V  +P   +   AS+
Sbjct: 205 PPCIVSTVPYHCVTPMASI 223



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 98/401 (24%), Positives = 122/401 (30%), Gaps = 67/401 (16%)

Query: 26   PNAHKVASPPSGPAYPDDV---LDYGLKPYSPLASLSGEPPGRFGEPDRVGPQ--KFLSA 80
            P A    SP  GPA P            P SP    +   P     P  V P   K   A
Sbjct: 965  PPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPA 1024

Query: 81   AKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLP------ 134
            A P      +P     PS +   A  PL               G   +P  TLP      
Sbjct: 1025 ATPFPKGASTPPAATPPSPKGSPAATPLPK-------------GAPTTPAATLPSPKGGP 1071

Query: 135  -VPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYS 193
              P  +G   P   +P S     +  S   +P   P  +P +       P  +  P   +
Sbjct: 1072 ATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMP-PAATPPSPKGGLATPPHKGAPT--T 1128

Query: 194  PRTSPIMSPRTSLAEDSCLGRHSPV----PRPASRSSSPGAKRRHSCAEALVALPPGASP 249
            P  +P  SP+  LA     G  +      P P    ++P  K   +   A    P G   
Sbjct: 1129 PAATP-PSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLA 1187

Query: 250  QRSRSPSPQPSSHVAPQDHG-----SPAGYPPVAGSAVIMDALNSLATDSPCGIP----- 299
              S   +P   +   P   G     SP G  P   +A        LAT SP G P     
Sbjct: 1188 TPSPKGAPTTPAATPPSPKGGLATPSPKG-APTTPAATPPSPKGGLATPSPKGAPTTPAA 1246

Query: 300  -------------PKMWKTSPDPSPVS-----AAPSKAGLPRHIYPAVEFLGPCEQGERR 341
                         PK   T P  +P S     A P   G P    PAV    P  +G   
Sbjct: 1247 TPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPN---PAV-VTPPSPKGGPA 1302

Query: 342  NSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLS 382
             S P+     PP    P     P    P  A  PP   P S
Sbjct: 1303 TSPPKG-APTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPS 1342



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 65/269 (24%), Positives = 97/269 (36%), Gaps = 36/269 (13%)

Query: 120  PPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNN-GGP 178
            PP  G    P  T P P  +G       +P+S G   +  S    P T P  +P++ GGP
Sbjct: 1327 PPPKGAPTPPAVTPPSP--KGTPTLPATTPSSKGGPTT-PSSKEGP-TPPAATPSHKGGP 1382

Query: 179  DDLCPQFQNIPAHYSPR---TSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHS 235
                P  +  PA  SP+   TSP + P +     +     +PV R  + + S G     +
Sbjct: 1383 AMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPA-----TPVTREGAATPSKGDLTPPA 1437

Query: 236  CAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSP 295
                 +   P  S     +P   P++  +  D   PA  PP   S     A   +AT S 
Sbjct: 1438 VTPVSLKKAPATS-----APKGGPATPSSKGDPTLPAVTPP---SPKEPPAPKQVATSS- 1488

Query: 296  CGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTW 355
                      SP  +P + AP  A     + P+     P     RR+    +  L+    
Sbjct: 1489 ----------SPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKT 1538

Query: 356  PKPLVP----AIPICSIPVTASLPPLEWP 380
            P  L P      P  ++P     P +  P
Sbjct: 1539 PATLAPKEALIPPAMTVPSPKKTPAIPTP 1567



 Score = 34.7 bits (78), Expect = 0.41
 Identities = 80/369 (21%), Positives = 130/369 (35%), Gaps = 56/369 (15%)

Query: 33   SPPSGPAYPD---DVLDYGLKPYSPLAS----LSGEPPGRFGEPDRVGPQKFLSAAKPAG 85
            SP  GPA P    D     + P SP  +    ++ E      + D   P     + K A 
Sbjct: 1388 SPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAP 1447

Query: 86   ASGLSPRIEITPSHE---LIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYR 142
            A+        TPS +    + AV P   ++       P     ++SP+     P   G  
Sbjct: 1448 ATSAPKGGPATPSSKGDPTLPAVTPPSPKEP----PAPKQVATSSSPKKAPATPAPMGAP 1503

Query: 143  EPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHY---SPRTSP- 198
                + P+S     +  S    P        +   P  L P+   IP      SP+ +P 
Sbjct: 1504 TLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPA 1563

Query: 199  IMSPRTSLAEDSCLGRHSP-VPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSP 257
            I +P+ + A  S     SP    P++   +P  K        L+  P   SP    +P+P
Sbjct: 1564 IPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKE-------LLIPPAVTSPSPKEAPTP 1616

Query: 258  Q----PSSH---VAPQDHGSPAGYPPVAGSAV---------IMDALNSLATDSPCGIPPK 301
                 PS       P   G+P   PPV  S++         +   + +    +  G+P K
Sbjct: 1617 PAVTPPSPEKGPATPAPKGTPTS-PPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAK 1675

Query: 302  MWKTS---------PDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVP 352
               T+         P+ +P+  AP++ G P+    +      C     +N +   +  V 
Sbjct: 1676 KGPTALKEVLVAPAPESTPIITAPTRKG-PQTKKSSATSPPICPDPSAKNGSKGPLSTVA 1734

Query: 353  PTWPKPLVP 361
            P    PL+P
Sbjct: 1735 PA---PLLP 1740


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 53.5 bits (127), Expect = 9e-07
 Identities = 83/307 (27%), Positives = 105/307 (34%), Gaps = 55/307 (17%)

Query: 120 PPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPD 179
           PPL G+ + P   L  P  +     L L P  +  S        SP  SP  +P+   P+
Sbjct: 601 PPLQGLPSPPLSPLATPPPQA-PPXLALPPLQAPPSPPA-----SPPLSPLATPSPQAPN 654

Query: 180 DLC----------PQFQNIPAHYSPRTSPIMSPRT---SLAEDSCLGRHSPVPR--PASR 224
            L           P    + A +SP  SP +SP     S A  S       VP   PAS 
Sbjct: 655 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 714

Query: 225 SSSPGAKRRHSCAEALVA----LPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGS 280
             SP A         L A    +PP        SPS  P   V P     P   PP   +
Sbjct: 715 PMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPA 774

Query: 281 AVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGER 340
           ++ M         SP   PP      P   P  A P    LP    P   F G       
Sbjct: 775 SLPM---------SPLAKPP------PQAPPALATPPLQALPS---PPASFPGQAPFSPS 816

Query: 341 RNSAPESILLVPPTWPKPLVPAIPICSIPVTASL---------PPLEWPLSSQSGSYELR 391
             S P S L  PP    P++ A P+  +P +            PP   P +S SG   L 
Sbjct: 817 A-SLPMSPLATPPPQAPPVL-AAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGP-RLT 873

Query: 392 IEVQPKP 398
           + + P P
Sbjct: 874 LALAPGP 880



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 61/227 (26%), Positives = 89/227 (39%), Gaps = 29/227 (12%)

Query: 189 PAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGAS 248
           PA  +    P   PR S++  S      P P    R S+ G  +R +      +  P +S
Sbjct: 192 PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSS 251

Query: 249 PQRS----RSPSPQPSSHVAPQDHG-----SPAGYPPVAGSAVIMDALNS--LATDSPCG 297
           P RS    R     P+    P+  G      P   PP   +A  +  L+S  LAT SP G
Sbjct: 252 PARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSG 311

Query: 298 IPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVP----- 352
                 K  P P P +AA     LP  + P+     P        SAP S+  +P     
Sbjct: 312 T-----KARPVPPPDNAATP---LPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPAT 363

Query: 353 -PTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKP 398
            P+   P +   P+ + P   ++PP++ P S  S S    ++  P P
Sbjct: 364 PPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPS----LQAPPSP 406



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 98/387 (25%), Positives = 136/387 (35%), Gaps = 52/387 (13%)

Query: 31  VASP--PSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASG 88
           V+SP   SG   P  +   GL+       +S E     G+      +  LSA      SG
Sbjct: 114 VSSPGRASGTTRPGPLGQKGLR-------ISAEETVARGKATEAPKRSALSAGARRDTSG 166

Query: 89  LSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAA------SPRFTLPVPGFEGYR 142
            +P    TPS  + +     R R AG  V  P  A  A        PR ++         
Sbjct: 167 PTPG---TPSPAMAR-----RSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTT 218

Query: 143 EPLCLS---PASSGSSASFISDTFSPYTSPCVSPNNGGPDDL-CPQFQNIPAHYSP---- 194
           EP   +   P++ G      S + S   +P  SP   GP     P+    P+   P    
Sbjct: 219 EPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQ 278

Query: 195 --RTSPIMSPRTSLAEDSCLGRHSPV--PRPASRSSSPGAKRRHSCAEALVALPPGAS-- 248
             R   +  PR   A        SP+  P P+   + P     ++       LPP     
Sbjct: 279 ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLA 338

Query: 249 ---PQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKT 305
              P    SPS  PS    P    +P    P + +   M A  SL T  P  +P  +  T
Sbjct: 339 TPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSL--T 396

Query: 306 SPD----PSPVSAAPSKA----GLPRHIYPAVEFLGPC-EQGERRNSAPESILLVPPTWP 356
           SP     PSP++ +  +A    G P  +     FL     Q +   ++P      PP  P
Sbjct: 397 SPSLQAPPSPLALSSLQATTSLGSPT-LQATHSFLTMSPRQTQASLTSPSRPASTPPDSP 455

Query: 357 KPLVPAIPICSIPVTASLPPLEWPLSS 383
               P     S P+  SL P   PLSS
Sbjct: 456 PLQAPLSLPASPPLQTSLSPAVSPLSS 482



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 88/354 (24%), Positives = 118/354 (33%), Gaps = 78/354 (22%)

Query: 50  KPYSPLASLSGEP---PGRFGEPDRVGPQK--FLSAAKPAGASGLSPRIEITPSHELIQA 104
           +P S   S S  P   P R G   R  P+     S  KP G   L P     P  +   A
Sbjct: 236 RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPA 295

Query: 105 VGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFS 164
           +GPL            PLA  + S     PVP  +    PL   PA+   S    +    
Sbjct: 296 LGPL---------SSSPLATPSPSGTKARPVPPPDNAATPL---PATLPPSPPLATPL-- 341

Query: 165 PYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASR 224
               P   P+   P    P  Q +P+   P T P  +P +            P+  P S 
Sbjct: 342 ----PLAPPSPSAP----PSLQTLPS--PPATPPSQAPPSMTTP--------PMQAPPSL 383

Query: 225 SSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQP-SSHVAPQDHGSPAGYPPVAGSAVI 283
            + P  +  HS            SP     PSP   SS  A    GSP            
Sbjct: 384 QTIPPIQVPHSLT----------SPSLQAPPSPLALSSLQATTSLGSPT----------- 422

Query: 284 MDALNSLATDSP------CGIPPKMWKTSPDPSPVSAA---PSKAGLPRHIYPAVEFLGP 334
           + A +S  T SP         P +   T PD  P+ A    P+   L   + PAV  L  
Sbjct: 423 LQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSS 482

Query: 335 ----------CEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLE 378
                              AP S L++PP   +  +    + + P + + PPLE
Sbjct: 483 PLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLE 536



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 103/429 (24%), Positives = 139/429 (32%), Gaps = 107/429 (24%)

Query: 14  PLRIMGSVDQEEPNA---HKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPD 70
           PL  + +   + PNA   H + +P S P  P     +   P SP  S S  PP +   P 
Sbjct: 641 PLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFS-PPASPPVSPSATPPSQ-APPS 698

Query: 71  RVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPR 130
              P   +  + PA    +SP     P      A  PL+       V   P A    SP 
Sbjct: 699 LAAPPLQVPPSPPASPP-MSPSATPPPQAPPPLAAPPLQ-------VPPSPPASPPMSPS 750

Query: 131 FTLP--VPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNI 188
            T P  VP       PL  +P      +   S   SP   P   P    P    P  Q +
Sbjct: 751 ATPPPRVP-------PLLAAPPLQVPPSPPASLPMSPLAKP---PPQAPPALATPPLQAL 800

Query: 189 P---------AHYSPRTSPIMSPRTS------------LAEDSCLGRHSPVPRPASRSSS 227
           P         A +SP  S  MSP  +            L +       SP  +   R  +
Sbjct: 801 PSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPT 860

Query: 228 PGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDAL 287
           PG     S     +AL PG  P  SRSPS             S    P +AG        
Sbjct: 861 PGPDTSVSGPRLTLALAPGPPPPPSRSPS-------------STLSGPDLAGH------- 900

Query: 288 NSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPES 347
           +S AT +P  +  + + + P+    ++ P  A            L  C            
Sbjct: 901 SSSATSTPEEL--RGYDSGPEGGAAASPPPDAE-----------LAACH----------- 936

Query: 348 ILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETE 407
               P  W +   P +     P      PL WP ++  GS +    +         YETE
Sbjct: 937 ----PAAWSRGPAPPLAFRGAPGA----PLPWPPATGPGSADGLCTI---------YETE 979

Query: 408 GSRGAVKAP 416
           G   A  AP
Sbjct: 980 GPESATPAP 988



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 95/383 (24%), Positives = 136/383 (35%), Gaps = 54/383 (14%)

Query: 33  SPPSGPAYPDDVLDYGLK------PYSPLASLSGEPPGRFGEPDRVGPQKFLSAA-KPAG 85
           +PPS    P   + + L       P SPLA  S +     G P       FL+ + +   
Sbjct: 379 APPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQ 438

Query: 86  ASGLSP-RIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREP 144
           AS  SP R   TP         PL          Q PL+  A+ P  T   P       P
Sbjct: 439 ASLTSPSRPASTPPDS-----PPL----------QAPLSLPASPPLQTSLSPAVSPLSSP 483

Query: 145 LCLSPASSGSSASFISDTFSPYTS----PCVSPNNGGPDDL--------CPQFQNIPAHY 192
           L + P  + SS +  S   +P +S    P  + ++  P  L         P  +N+P+  
Sbjct: 484 LTIHPLQALSSLASHSPQ-APLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLA 542

Query: 193 SPRTSPIMSPRTS--LAEDSC------LGRHSPVPRPASRSSSPGAKRRHSCAEALVALP 244
            P      +P T+  L    C          SP+  P   + S  A        AL + P
Sbjct: 543 PPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPP 602

Query: 245 PGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWK 304
               P    SP   P     P     P   PP   ++  +  L + +  +P  +   + +
Sbjct: 603 LQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ 662

Query: 305 T--SPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWP--KPLV 360
              SP PSP   AP        + P+     P  Q     +AP   L VPP+ P   P+ 
Sbjct: 663 APFSPPPSPPVQAPFSPPASPPVSPSAT---PPSQAPPSLAAPP--LQVPPSPPASPPMS 717

Query: 361 P-AIPICSIPVTASLPPLEWPLS 382
           P A P    P   + PPL+ P S
Sbjct: 718 PSATPPPQAPPPLAAPPLQVPPS 740



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 88/369 (23%), Positives = 132/369 (35%), Gaps = 61/369 (16%)

Query: 58  LSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLV 117
           L+  PPG    P  V P    +A +  GA+G   R    P  E    +G   + ++    
Sbjct: 25  LTPRPPGSPRPPPPVTP----AALRVLGAAGAVGR---KPLAERAGGIGGATIPESAPRA 77

Query: 118 EQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGG 177
                AG ++    + P     G R P    PA + S          P +SP  +     
Sbjct: 78  GPTRSAGTSSRNPASRPPASGRGERAP----PAKNTSPG--------PVSSPGRASGTTR 125

Query: 178 PDDLCPQFQNIPAHYS-PRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSC 236
           P  L  +   I A  +  R     +P+ S       G       P   + SP   RR   
Sbjct: 126 PGPLGQKGLRISAEETVARGKATEAPKRSALS---AGARRDTSGPTPGTPSPAMARRSRA 182

Query: 237 AEALVALPPGASPQRSRSPSPQPSSHV-APQDHGSPAGYP-----PVAGSAVIMDALNSL 290
           A   V LP  A   R R P+  P   V +  +H +    P     P AG  +   A  SL
Sbjct: 183 AGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSL 242

Query: 291 ATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPR-HIYPA------VEFLGPCE-QGERRN 342
           ++ +           +P  SP  + PS  G PR   +P+      ++ L P +    R++
Sbjct: 243 SSSA-----------TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKD 291

Query: 343 SAPE--SILLVPPTWPKPL------VPAIPICSIPVTASLPP-----LEWPLSSQSGSYE 389
           +AP    +   P   P P       VP     + P+ A+LPP        PL+  S S  
Sbjct: 292 AAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAP 351

Query: 390 LRIEVQPKP 398
             ++  P P
Sbjct: 352 PSLQTLPSP 360


>gi|237757310 synaptojanin 1 isoform a [Homo sapiens]
          Length = 1612

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 87/375 (23%), Positives = 135/375 (36%), Gaps = 52/375 (13%)

Query: 144  PLCLSPASSGSSASFISDTFSPYTSPCVSPN-NGGPDDLCPQFQNIPAHYSPRTSPIMSP 202
            P  L P+SS    +  S + SP TSPC SP  + GP    P          P  +P  +P
Sbjct: 1066 PQHLQPSSSSGLGT--SPSSSPRTSPCQSPTISEGPVPSLP--------IRPSRAPSRTP 1115

Query: 203  RTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSH 262
                A+ S +      P P    + P   +R      +      A PQR   PS   S  
Sbjct: 1116 GPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPA 1175

Query: 263  VAPQDHGSPAGYPPVAGSA-VIMDALNSLATDSPCGI-----PPKMWKTSPDPSPVSAA- 315
               ++ G   G PP  G A   M+A  S  T     I      P+     P P+  S A 
Sbjct: 1176 PTRKEFGG-IGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTAR 1234

Query: 316  ---PSKAGL----PRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSI 368
               P +AG+      H   +   L P  Q +   ++  S  L  P  P+   P  P  S+
Sbjct: 1235 PTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFP--PQSSL 1292

Query: 369  PVTAS-----LPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVV 423
            P  A      L P+  P+        L    QP P  R+ +       ++ +     P V
Sbjct: 1293 PPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSH-------SLPSEASSQPQV 1345

Query: 424  QLHGYMENK---PLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLE 480
            + +G  + K   PL +  F   +   +    A   V          TS        ++++
Sbjct: 1346 KTNGISDGKRESPLKIDPFEDLSFNLLAVSKAQLSVQ---------TSPVPTPDPKRLIQ 1396

Query: 481  IPLEPKNNMRATIDC 495
            +P   ++N+ +++ C
Sbjct: 1397 LPSATQSNVLSSVSC 1411


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 99/408 (24%), Positives = 133/408 (32%), Gaps = 109/408 (26%)

Query: 14  PLRIMGSVDQEEPNA---HKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPD 70
           PL  + +   + PNA   H + +P S P  P     +   P SP  S S  PP +   P 
Sbjct: 416 PLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFS-PPASPPVSPSATPPSQ-APPS 473

Query: 71  RVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLA--GVAAS 128
              P   +  + PA    +SP     P      A  PL+      L + PP A   +A  
Sbjct: 474 LAAPPLQVPPSPPASPP-MSPSATPPPQAPPPLAAPPLQ------LAKPPPQAPPALATP 526

Query: 129 PRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNI 188
           P   LP P            PAS    A F      P  SP  +P    P  L      +
Sbjct: 527 PLQALPSP------------PASFPGQAPFSPSASLPM-SPLATPPPQAPPVLAAPLLQV 573

Query: 189 PAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGAS 248
           P   SP  SP +             R  P P P +  S P            +AL PG  
Sbjct: 574 PP--SPPASPTLQAP----------RRPPTPGPDTSVSGP---------RLTLALAPGPP 612

Query: 249 PQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPD 308
           P  SRSPS             S    P +AG        +S AT +P  +  + + + P+
Sbjct: 613 PPPSRSPS-------------STLSGPDLAGH-------SSSATSTPEEL--RGYDSGPE 650

Query: 309 PSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSI 368
               ++ P  A            L  C                P  W +   P +     
Sbjct: 651 GGAAASPPPDAE-----------LAACH---------------PAAWSRGPAPPLAFRGA 684

Query: 369 PVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAP 416
           P      PL WP ++  GS +    +         YETEG   A  AP
Sbjct: 685 PGA----PLPWPPATGPGSADGLCTI---------YETEGPESATPAP 719



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 86/344 (25%), Positives = 113/344 (32%), Gaps = 72/344 (20%)

Query: 50  KPYSPLASLSGEP---PGRFGEPDRVGPQK--FLSAAKPAGASGLSPRIEITPSHELIQA 104
           +P S   S S  P   P R G   R  P+     S  KP G   L P     P  +   A
Sbjct: 236 RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPA 295

Query: 105 VGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFS 164
           +GPL    +  L    P A + +    TLP             +P SS  +    +    
Sbjct: 296 LGPL---SSSPLATPSPSAALQSQAPPTLPA------------TPHSSSLTCQLATPL-- 338

Query: 165 PYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASR 224
               P   P+   P    P  Q +P   SP  +P     TSL                  
Sbjct: 339 ----PLAPPSPSAP----PSLQTLP---SPPATPPSQATTSLG----------------- 370

Query: 225 SSSPGAKRRHSCAEA-----LVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAG 279
             SP  +  HS   +     L   PP A P  +  P   P S  A       A   P A 
Sbjct: 371 --SPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAP 428

Query: 280 SAVIMDALNSLATDSPCGIPPKMWKTSPDPSP---VSAAPSKAGLPRHIYPAVEFLGPCE 336
           +A+ +  L   A  SP   PP     SP  SP    SA P     P    P ++      
Sbjct: 429 NALAVHLLQ--APFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV----- 481

Query: 337 QGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWP 380
                 S P S  + P   P P  P  P+ + P+  + PP + P
Sbjct: 482 ----PPSPPASPPMSPSATPPPQAPP-PLAAPPLQLAKPPPQAP 520



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 92/397 (23%), Positives = 137/397 (34%), Gaps = 55/397 (13%)

Query: 58  LSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLV 117
           L+  PPG    P  V P    +A +  GA+G   R    P  E    +G   + ++    
Sbjct: 25  LTPRPPGSPRPPPPVTP----AALRVLGAAGAVGR---KPLAERAGGIGGATIPESAPRA 77

Query: 118 EQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGG 177
                AG ++    + P     G R P    PA + S          P +SP  +     
Sbjct: 78  GPTRSAGTSSRNPASRPPASGRGERAP----PAKNTSPG--------PVSSPGRASGTTR 125

Query: 178 PDDLCPQFQNIPAHYS-PRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSC 236
           P  L  +   I A  +  R     +P+ S       G       P   + SP   RR   
Sbjct: 126 PGPLGQKGLRISAEETVARGKATEAPKRSALS---AGARRDTSGPTPGTPSPAMARRSRA 182

Query: 237 AEALVALPPGASPQRSRSPSPQPSSHV-APQDHGSPAGYP-----PVAGSAVIMDALNSL 290
           A   V LP  A   R R P+  P   V +  +H +    P     P AG  +   A  SL
Sbjct: 183 AGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSL 242

Query: 291 ATD-SPCGIPPKMWKTSPDPSPVSAAPS-------KAGLPRHIYP----AVEFLGPCEQG 338
           ++  +P   P +   ++       A PS       +A  P  + P    A   LGP    
Sbjct: 243 SSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 302

Query: 339 ERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKP 398
                +P + L    +   P +PA P  S        PL  PL+  S S    ++  P P
Sbjct: 303 PLATPSPSAAL---QSQAPPTLPATPHSSSLTCQLATPL--PLAPPSPSAPPSLQTLPSP 357

Query: 399 HHRAHYETEGSRGAVKAPTGGHPVVQ-LHGYMENKPL 434
                 +   S G+        P +Q  H ++ + PL
Sbjct: 358 PATPPSQATTSLGS--------PTLQATHSFLPSPPL 386


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 99/408 (24%), Positives = 133/408 (32%), Gaps = 109/408 (26%)

Query: 14  PLRIMGSVDQEEPNA---HKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPD 70
           PL  + +   + PNA   H + +P S P  P     +   P SP  S S  PP +   P 
Sbjct: 377 PLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFS-PPASPPVSPSATPPSQ-APPS 434

Query: 71  RVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLA--GVAAS 128
              P   +  + PA    +SP     P      A  PL+      L + PP A   +A  
Sbjct: 435 LAAPPLQVPPSPPASPP-MSPSATPPPQAPPPLAAPPLQ------LAKPPPQAPPALATP 487

Query: 129 PRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNI 188
           P   LP P            PAS    A F      P  SP  +P    P  L      +
Sbjct: 488 PLQALPSP------------PASFPGQAPFSPSASLPM-SPLATPPPQAPPVLAAPLLQV 534

Query: 189 PAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGAS 248
           P   SP  SP +             R  P P P +  S P            +AL PG  
Sbjct: 535 PP--SPPASPTLQAP----------RRPPTPGPDTSVSGP---------RLTLALAPGPP 573

Query: 249 PQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPD 308
           P  SRSPS             S    P +AG        +S AT +P  +  + + + P+
Sbjct: 574 PPPSRSPS-------------STLSGPDLAGH-------SSSATSTPEEL--RGYDSGPE 611

Query: 309 PSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSI 368
               ++ P  A            L  C                P  W +   P +     
Sbjct: 612 GGAAASPPPDAE-----------LAACH---------------PAAWSRGPAPPLAFRGA 645

Query: 369 PVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAP 416
           P      PL WP ++  GS +    +         YETEG   A  AP
Sbjct: 646 PGA----PLPWPPATGPGSADGLCTI---------YETEGPESATPAP 680



 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 82/335 (24%), Positives = 115/335 (34%), Gaps = 55/335 (16%)

Query: 63  PGRFGEPDRVGPQKFLSAAKPAGASGLSPRIEITPSHEL-IQAVGPLRMRDAGLLVEQPP 121
           P     P   GP+K +S+A     +  SP     PS    +Q      +  +   +  P 
Sbjct: 185 PSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPA 244

Query: 122 LAGVAA--SPRF----TLPVP-GFEGYREPLCLSPASSGSSA-SFISDTFSPYTSPCVSP 173
            +G +A  +PR     + P P G +  R P    P    + A   +S +     SP   P
Sbjct: 245 RSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPP 304

Query: 174 NNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRR 233
           +   P    P  Q +P   SP  +P     TSL                    SP  +  
Sbjct: 305 SPSAP----PSLQTLP---SPPATPPSQATTSLG-------------------SPTLQAT 338

Query: 234 HSCAEA-----LVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALN 288
           HS   +     L   PP A P  +  P   P S  A       A   P A +A+ +  L 
Sbjct: 339 HSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ 398

Query: 289 SLATDSPCGIPPKMWKTSPDPSP---VSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAP 345
             A  SP   PP     SP  SP    SA P     P    P ++            S P
Sbjct: 399 --APFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV---------PPSPP 447

Query: 346 ESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWP 380
            S  + P   P P  P  P+ + P+  + PP + P
Sbjct: 448 ASPPMSPSATPPPQAPP-PLAAPPLQLAKPPPQAP 481



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 88/363 (24%), Positives = 130/363 (35%), Gaps = 64/363 (17%)

Query: 58  LSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLV 117
           L+  PPG    P  V P    +A +  GA+G   R    P  E    +G         + 
Sbjct: 25  LTPRPPGSPRPPPPVTP----AALRVLGAAGAVGR---KPLAERAGGIG------GATIP 71

Query: 118 EQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGG 177
           E  P AG   + R   P     G R P    PA + S          P +SP  +     
Sbjct: 72  ESAPRAGPTRTSR---PPASGRGERAP----PAKNTSPG--------PVSSPGRASGTTR 116

Query: 178 PDDLCPQFQNIPAHYS-PRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSC 236
           P  L  +   I A  +  R     +P+ S       G       P   + SP   RR   
Sbjct: 117 PGPLGQKGLRISAEETVARGKATEAPKRSALS---AGARRDTSGPTPGTPSPAMARRSRA 173

Query: 237 AEALVALPPGASPQRSRSPSPQPSSHV-APQDHGSPAGYP-----PVAGSAVIMDALNSL 290
           A   V LP  A   R R P+  P   V +  +H +    P     P AG  +   A  SL
Sbjct: 174 AGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSL 233

Query: 291 ATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPR-HIYPA------VEFLGPCE-QGERRN 342
           ++ +           +P  SP  + PS  G PR   +P+      ++ L P +    R++
Sbjct: 234 SSSA-----------TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKD 282

Query: 343 SAP-----ESILLVPPTWPKPLVPAIP--ICSIPVTASLPPLEWPLSSQSGSYELRIEVQ 395
           +AP      S  L  P+   P  P+ P  + ++P   + PP +   S  S + +      
Sbjct: 283 AAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFL 342

Query: 396 PKP 398
           P P
Sbjct: 343 PSP 345


>gi|237757308 synaptojanin 1 isoform b [Homo sapiens]
          Length = 1350

 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 73/281 (25%), Positives = 101/281 (35%), Gaps = 33/281 (11%)

Query: 144  PLCLSPASSGSSASFISDTFSPYTSPCVSPN-NGGPDDLCPQFQNIPAHYSPRTSPIMSP 202
            P  L P+SS    +  S + SP TSPC SP  + GP    P          P  +P  +P
Sbjct: 1066 PQHLQPSSSSGLGT--SPSSSPRTSPCQSPTISEGPVPSLP--------IRPSRAPSRTP 1115

Query: 203  RTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSH 262
                A+ S +      P P    + P   +R      +      A PQR   PS   S  
Sbjct: 1116 GPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPA 1175

Query: 263  VAPQDHGSPAGYPPVAGSA-VIMDALNSLATDSPCGI-----PPKMWKTSPDPSPVSAA- 315
               ++ G   G PP  G A   M+A  S  T     I      P+     P P+  S A 
Sbjct: 1176 PTRKEFGG-IGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTAR 1234

Query: 316  ---PSKAGL----PRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSI 368
               P +AG+      H   +   L P  Q +   ++  S  L  P  P+   P  P  S+
Sbjct: 1235 PTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFP--PQSSL 1292

Query: 369  PVTAS-----LPPLEWPLSSQSGSYELRIEVQPKPHHRAHY 404
            P  A      L P+  P+        L    QP P  R+ +
Sbjct: 1293 PPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSH 1333


>gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [Homo
            sapiens]
          Length = 1636

 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 99/453 (21%), Positives = 143/453 (31%), Gaps = 91/453 (20%)

Query: 23   QEEPNAHKVASPP-----------SGPAYPDDVLDYGLK---PYSPLASLSGEPPGRFGE 68
            +EE  A +   PP           +GP  PD  L        P SP  S +G  P     
Sbjct: 730  REESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSSTGPGPHYLSG 789

Query: 69   P----DRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAG 124
            P       GP + +    P   +     + + P   L  A  P    + GL+    P  G
Sbjct: 790  PLPPGTYSGPTQLIQPRAPGPHA-----MPVAPGPALYPA--PAYTPELGLVPRSSPQHG 842

Query: 125  VAASPRFTL-PVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCP 183
            V +SP   + P P   G   P    P  SG           P  +  V P     D +  
Sbjct: 843  VVSSPYVGVGPAPPVAGL--PSAPPPQFSG-----------PELAMAVRPATTTVDSIQA 889

Query: 184  QFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVAL 243
                IP+H +PR +P  +P        C     P P P   +   GAK+         + 
Sbjct: 890  P---IPSHTAPRPNPTPAP-----PPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSG 941

Query: 244  PPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMW 303
             P   P     P PQP     PQ H S A  P      + +   +     +P  +PP+  
Sbjct: 942  IPAGFPAPRIGPQPQPH----PQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQ-- 995

Query: 304  KTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAI 363
                 P P +  P   G P        + GP +     +S   ++    P  P+P  P +
Sbjct: 996  ----SPYPYAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSG--ALPFPSPGPPQPPHPPL 1049

Query: 364  PICSIPVTASLPPLEWPLS----SQSGSYELRIEVQPKPHHRA----------------- 402
                 P T  + P   PL+    S +G       + P P                     
Sbjct: 1050 AYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLVPSPAPSPGPGPVPPRPPAAEPPPC 1109

Query: 403  -----------HYETEGSRGAVKAPTGGHPVVQ 424
                           E   G  ++P GG P++Q
Sbjct: 1110 LRRGAAAADLLSSSPESQHGGTQSPGGGQPLLQ 1142



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 79/320 (24%), Positives = 105/320 (32%), Gaps = 58/320 (18%)

Query: 18   MGSVDQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKF 77
            +G V +  P    V+SP             G+ P  P+A L   PP +F  P+       
Sbjct: 831  LGLVPRSSPQHGVVSSPY-----------VGVGPAPPVAGLPSAPPPQFSGPE------L 873

Query: 78   LSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPG 137
              A +PA           T + + IQA  P            PP       P   LP P 
Sbjct: 874  AMAVRPA-----------TTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQPLPTPY 922

Query: 138  F--EGYREPLCLSPA----SSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAH 191
                G ++P+   PA    SSG  A F +    P   P   P+        P  Q +P  
Sbjct: 923  TYPAGAKQPI---PAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQPLPLQ 979

Query: 192  Y-------SPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALP 244
            +       +P   P  SP     +   LG+  P   P      PG       A+  +   
Sbjct: 980  HPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPP---PLHTQLYPGP------AQDPLPAH 1030

Query: 245  PGASPQRSRSP--SPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKM 302
             GA P  S  P   P P     P     P G P  A   +   +    +T SP  +P   
Sbjct: 1031 SGALPFPSPGPPQPPHPPLAYGPAPSTRPMG-PQAAPLTIRGPSSAGQSTPSPHLVPSP- 1088

Query: 303  WKTSPDPSPVSAAPSKAGLP 322
               SP P PV   P  A  P
Sbjct: 1089 -APSPGPGPVPPRPPAAEPP 1107


>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
          Length = 1526

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 75/343 (21%), Positives = 115/343 (33%), Gaps = 48/343 (13%)

Query: 176  GGPDDLCPQFQNI-PAHYSPR------TSPIMSPRTSLAEDSCLGRHSPVP--------R 220
            G  DD   + + + P H  P       TSP  SPRTS  +   +    PVP         
Sbjct: 1008 GDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTIS-EGPVPSLPIRPSRA 1066

Query: 221  PASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGS 280
            P+     P A+     A+    LP     Q      P P   VAP    +P   PP    
Sbjct: 1067 PSRTPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSG 1126

Query: 281  AVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGER 340
                     LA   P G         P    +SA  S      H   +   L P  Q + 
Sbjct: 1127 RSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQS------HARASAGRLTPESQSKT 1180

Query: 341  RNSAPESILLVPPTWPKPLVPAIPICSIPVTAS-----LPPLEWPLSSQSGSYELRIEVQ 395
              ++  S  L  P  P+   P  P  S+P  A      L P+  P+        L    Q
Sbjct: 1181 SETSKGSTFLPEPLKPQAAFP--PQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQ 1238

Query: 396  PKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENK---PLGLQIFIGTADERILKPHA 452
            P P  R+ +       ++ +     P V+ +G  + K   PL +  F   +   +    A
Sbjct: 1239 PPPRSRSSH-------SLPSEASSQPQVKTNGISDGKRESPLKIDPFEDLSFNLLAVSKA 1291

Query: 453  FYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDC 495
               V          TS        +++++P   ++N+ +++ C
Sbjct: 1292 QLSVQ---------TSPVPTPDPKRLIQLPSATQSNVLSSVSC 1325



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 76/275 (27%), Positives = 103/275 (37%), Gaps = 41/275 (14%)

Query: 144  PLCLSPASSGSSASFISDTFSPYTSPCVSPN-NGGPDDLCPQFQNIPAHYSPRTSPIMSP 202
            P  L P+SS    +  S + SP TSPC SP  + GP    P          P  +P  +P
Sbjct: 1022 PQHLQPSSSSGLGT--SPSSSPRTSPCQSPTISEGPVPSLP--------IRPSRAPSRTP 1071

Query: 203  RTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPS--PQPS 260
                A+ S +      P P    + P   +R      +      A PQR   PS   QPS
Sbjct: 1072 GPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGRSQPS 1131

Query: 261  SHVAPQDHGSPAGY----PPVAGSAVIMDALNSLATDSPCGIPPK-MWKTS--------- 306
                    G PAGY    P +   A ++ A  S A  S   + P+   KTS         
Sbjct: 1132 PQAGLAGPG-PAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFL 1190

Query: 307  PDP-SPVSAAPSKAGLP----RHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVP 361
            P+P  P +A P ++ LP    R   P V    P  Q     S P+  L  P   P+P   
Sbjct: 1191 PEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQ-----SGPQPNLETP---PQPPPR 1242

Query: 362  AIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQP 396
            +    S+P  AS  P         G  E  +++ P
Sbjct: 1243 SRSSHSLPSEASSQPQVKTNGISDGKRESPLKIDP 1277


>gi|41281612 zinc finger protein 828 [Homo sapiens]
          Length = 812

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 75/331 (22%), Positives = 112/331 (33%), Gaps = 28/331 (8%)

Query: 79  SAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGF 138
           ++A+P     LS   +     +L   + P   +   L   +P   G   SP    P+P  
Sbjct: 120 NSAEPKSIPALSMETQ-----KLGSVLSPESPKPTPLTPLEPQKPGSVVSPELQTPLPSP 174

Query: 139 EGYREPLCLSPASSGSSASFISDTFSPYTSP-CVSPNNGGPDDLCPQFQNIPAHYSPRTS 197
           E  +     SP    S     S   +P  SP    P    P+ +     N          
Sbjct: 175 EPSKPASVSSPEPPKSVPVCESQKLAPVPSPEPQKPAPVSPESVKATLSNPKPQKQSHFP 234

Query: 198 PIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSP 257
             + P ++ + +S +   SP P   S ++SP +++      A    P    P  S SP P
Sbjct: 235 ETLGPPSASSPESPVLAASPEPWGPSPAASPESRK-----SARTTSPEPRKPSPSESPEP 289

Query: 258 -QPSSHVAPQDHG-----SPAGYPPVAGSAVIMDALNSLATDSPC-------GIPPKMWK 304
            +P   V+P+        SP  + P    +      N  A+  P         + P  WK
Sbjct: 290 WKPFPAVSPEPRRPAPAVSPGSWKPGPPGSPRPWKSNPSASSGPWKPAKPAPSVSPGPWK 349

Query: 305 TSPDPSPVSAAP----SKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLV 360
             P  SP    P    S A           +  P    E   S P  +    PT      
Sbjct: 350 PIPSVSPGPWKPTPSVSSASWKSSSVSPSSWKSPPASPESWKSGPPELRKTAPTLSPEHW 409

Query: 361 PAIPICSIPVTASLPPLEWPLSSQSGSYELR 391
            A+P  S  +    PPL   + S +GS ELR
Sbjct: 410 KAVPPVSPELRKPGPPLSPEIRSPAGSPELR 440



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 82/341 (24%), Positives = 110/341 (32%), Gaps = 58/341 (17%)

Query: 32  ASPPSGPAYPDDVLDYG--LKPYSP----LASLSGEPPGRFGEPDRVGPQKFLSAAKPAG 85
           A P S PA   +    G  L P SP    L  L  + PG    P+   P      +KPA 
Sbjct: 122 AEPKSIPALSMETQKLGSVLSPESPKPTPLTPLEPQKPGSVVSPELQTPLPSPEPSKPAS 181

Query: 86  ASGLSP--RIEITPSHELIQAVGPLRMRDAGLLVEQ---------------------PPL 122
            S   P   + +  S +L     P   + A +  E                      PP 
Sbjct: 182 VSSPEPPKSVPVCESQKLAPVPSPEPQKPAPVSPESVKATLSNPKPQKQSHFPETLGPPS 241

Query: 123 AG------VAASPRFTLPVPGF--EGYREPLCLSPASSGSSASFISDTFSPYTS------ 168
           A       +AASP    P P    E  +     SP     S S   + + P+ +      
Sbjct: 242 ASSPESPVLAASPEPWGPSPAASPESRKSARTTSPEPRKPSPSESPEPWKPFPAVSPEPR 301

Query: 169 ---PCVSPNN---GGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPA 222
              P VSP +   G P    P   N  A   P      +P  S      +   SP P   
Sbjct: 302 RPAPAVSPGSWKPGPPGSPRPWKSNPSASSGPWKPAKPAPSVSPGPWKPIPSVSPGPWKP 361

Query: 223 SRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAV 282
           + S S  + +  S + +    PP ASP+  +S  P+                PPV+    
Sbjct: 362 TPSVSSASWKSSSVSPSSWKSPP-ASPESWKSGPPELRKTAPTLSPEHWKAVPPVSPELR 420

Query: 283 IMDALNSLATDSPCGIP--------PKMWKTSPDPSPVSAA 315
                 S    SP G P        P +WK SPD    S A
Sbjct: 421 KPGPPLSPEIRSPAGSPELRKPSGSPDLWKLSPDQRKTSPA 461


>gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]
          Length = 1970

 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 54/184 (29%), Positives = 70/184 (38%), Gaps = 14/184 (7%)

Query: 147  LSPASSGSSASFISDT--FSPYTSPCVSPNNGGPDDLCPQFQNIPA-------HYSPRTS 197
            ++P ++G S S  SD   FSP  SP  SP  G P    P    IP+        YSP TS
Sbjct: 1539 MTPGAAGFSPSAASDASGFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSP-TS 1597

Query: 198  PIMSPRTS---LAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASP-QRSR 253
            P   PR+      +       SP   P S S SP +      + +     P  SP   S 
Sbjct: 1598 PAYEPRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSY 1657

Query: 254  SPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVS 313
            SP+    S  +P    +   Y P + S        S  + S     P    TSP  SP S
Sbjct: 1658 SPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTS 1717

Query: 314  AAPS 317
             + S
Sbjct: 1718 PSYS 1721



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 68/255 (26%), Positives = 95/255 (37%), Gaps = 27/255 (10%)

Query: 85   GASGLSPRIE-----ITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFE 139
            GA+G SP         +P +    +  P      G      P  G A SP ++   P +E
Sbjct: 1542 GAAGFSPSAASDASGFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYE 1601

Query: 140  -----GYREPLCLSPASSGSSASF--ISDTFSPY------TSPCVSPNNGGPDDLCPQFQ 186
                 GY      SP+ S +S S+   S ++SP       TSP  SP +       P + 
Sbjct: 1602 PRSPGGYTPQ---SPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYS 1658

Query: 187  NIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVP---RPASRSSSPGAKRRHSCAEALVAL 243
                 YSP TSP  SP TS +       +SP      P S S SP +      + +    
Sbjct: 1659 PTSPSYSP-TSPSYSP-TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPT 1716

Query: 244  PPGASPQR-SRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKM 302
             P  SP   S SP+    S  +P    +   Y P + +        S  + S     P  
Sbjct: 1717 SPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNY 1776

Query: 303  WKTSPDPSPVSAAPS 317
              TSP+ SP S + S
Sbjct: 1777 TPTSPNYSPTSPSYS 1791



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 52/172 (30%), Positives = 69/172 (40%), Gaps = 9/172 (5%)

Query: 148  SPASSGSSASF--ISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTS 205
            SP+ S +S S+   S ++SP TSP  SP +       P +      YSP TSP  SP TS
Sbjct: 1682 SPSYSPTSPSYSPTSPSYSP-TSPSYSPTSPSYSPTSPSYSPTSPSYSP-TSPSYSP-TS 1738

Query: 206  LAEDSCLGRHSPVP---RPASRSSSPGAKRRHSCAEALVALPPGASPQR-SRSPSPQPSS 261
             +       +SP      P S S SP +      +       P  SP   S SP+    S
Sbjct: 1739 PSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYS 1798

Query: 262  HVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVS 313
              +P    S   Y P + +        S ++ S     PK   TSP  SP S
Sbjct: 1799 PTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSS 1850


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,774,798
Number of Sequences: 37866
Number of extensions: 2645264
Number of successful extensions: 10985
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 611
Number of HSP's that attempted gapping in prelim test: 9016
Number of HSP's gapped (non-prelim): 2095
length of query: 901
length of database: 18,247,518
effective HSP length: 111
effective length of query: 790
effective length of database: 14,044,392
effective search space: 11095069680
effective search space used: 11095069680
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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