Search of human proteins with 20806097

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20806097 nucleolar complex associated 3 homolog [Homo
sapiens]
         (800 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20806097 nucleolar complex associated 3 homolog [Homo sapiens]    1561   0.0  
gi|34577114 cytomatrix protein p110 [Homo sapiens]                     55   2e-07
gi|71061468 centromere protein E [Homo sapiens]                        55   3e-07
gi|221219020 NYD-SP11 protein [Homo sapiens]                           54   4e-07
gi|110349719 titin isoform N2-A [Homo sapiens]                         54   6e-07
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    54   7e-07
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...    53   1e-06
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...    53   1e-06
gi|100814339 coiled-coil domain containing 146 [Homo sapiens]          53   1e-06
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    53   1e-06
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    52   2e-06
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    52   2e-06
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    52   2e-06
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    52   2e-06
gi|64085252 hypothetical protein LOC145508 [Homo sapiens]              52   2e-06
gi|41872583 Rho-associated, coiled-coil containing protein kinas...    52   3e-06
gi|31982906 cingulin-like 1 [Homo sapiens]                             52   3e-06
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]    51   4e-06
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    51   5e-06
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    50   6e-06
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    50   6e-06
gi|13129068 nucleolar complex associated 4 homolog [Homo sapiens]      50   6e-06
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    50   8e-06
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             50   1e-05
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     49   1e-05
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    49   1e-05
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    49   2e-05
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho...    49   2e-05
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         49   2e-05
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         49   2e-05

>gi|20806097 nucleolar complex associated 3 homolog [Homo sapiens]
          Length = 800

 Score = 1561 bits (4041), Expect = 0.0
 Identities = 800/800 (100%), Positives = 800/800 (100%)

Query: 1   MKARRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKK 60
           MKARRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKK
Sbjct: 1   MKARRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKK 60

Query: 61  PIPLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPV 120
           PIPLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPV
Sbjct: 61  PIPLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPV 120

Query: 121 HAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQ 180
           HAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQ
Sbjct: 121 HAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQ 180

Query: 181 EEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELR 240
           EEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELR
Sbjct: 181 EEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELR 240

Query: 241 SMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEG 300
           SMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEG
Sbjct: 241 SMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEG 300

Query: 301 LVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHN 360
           LVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHN
Sbjct: 301 LVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHN 360

Query: 361 NIIVLIVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEM 420
           NIIVLIVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEM
Sbjct: 361 NIIVLIVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEM 420

Query: 421 LKTFLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERELREAEA 480
           LKTFLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERELREAEA
Sbjct: 421 LKTFLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERELREAEA 480

Query: 481 SESTEKKLKLHTETLNIVFVTYFRILKKAQRSPLLPAVLEGLAKFAHLINVEFFDDLLVV 540
           SESTEKKLKLHTETLNIVFVTYFRILKKAQRSPLLPAVLEGLAKFAHLINVEFFDDLLVV
Sbjct: 481 SESTEKKLKLHTETLNIVFVTYFRILKKAQRSPLLPAVLEGLAKFAHLINVEFFDDLLVV 540

Query: 541 LHTLIESGDLSYQESLHCVQTAFHILSGQGDVLNIDPLKFYTHLYKTLFKLHAGATNEGV 600
           LHTLIESGDLSYQESLHCVQTAFHILSGQGDVLNIDPLKFYTHLYKTLFKLHAGATNEGV
Sbjct: 541 LHTLIESGDLSYQESLHCVQTAFHILSGQGDVLNIDPLKFYTHLYKTLFKLHAGATNEGV 600

Query: 601 EIVLQCLDVMLTKRRKQVSQQRALAFIKRLCTLALHVLPNSSIGILATTRILMHTFPKTD 660
           EIVLQCLDVMLTKRRKQVSQQRALAFIKRLCTLALHVLPNSSIGILATTRILMHTFPKTD
Sbjct: 601 EIVLQCLDVMLTKRRKQVSQQRALAFIKRLCTLALHVLPNSSIGILATTRILMHTFPKTD 660

Query: 661 LLLDSESQGSGVFLPELDEPEYCNAQNTALWELHALRRHYHPIVQRFAAHLIAGAPSEGS 720
           LLLDSESQGSGVFLPELDEPEYCNAQNTALWELHALRRHYHPIVQRFAAHLIAGAPSEGS
Sbjct: 661 LLLDSESQGSGVFLPELDEPEYCNAQNTALWELHALRRHYHPIVQRFAAHLIAGAPSEGS 720

Query: 721 GALKPELSRRSATELFEAYSMAEMTFNPPVESSNPKIKGKFLQGDSFLNEDLNQLIKRYS 780
           GALKPELSRRSATELFEAYSMAEMTFNPPVESSNPKIKGKFLQGDSFLNEDLNQLIKRYS
Sbjct: 721 GALKPELSRRSATELFEAYSMAEMTFNPPVESSNPKIKGKFLQGDSFLNEDLNQLIKRYS 780

Query: 781 SEVATESPLDFTKYLKTSLH 800
           SEVATESPLDFTKYLKTSLH
Sbjct: 781 SEVATESPLDFTKYLKTSLH 800


>gi|34577114 cytomatrix protein p110 [Homo sapiens]
          Length = 957

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 74/329 (22%), Positives = 144/329 (43%), Gaps = 37/329 (11%)

Query: 4   RRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSK-KPI 62
           R   ++I SFRK  K  K K+ N L+ +  +++S+L   ++    L  A     SK K +
Sbjct: 609 RERLEEIESFRKENKDLKEKV-NALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSL 667

Query: 63  PLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHA 122
            +   ++K    ++E + ++           EDD ++  +   ++  L ++ S       
Sbjct: 668 EIAIEQKKEECSKLEAQLKKAHNI-------EDDSRMNPEFADQIKQLDKEASYYRDECG 720

Query: 123 KKRKH-ERIIDKYEKIPRTLQTAPEK----ELIHLLPIKDKSGIIPQTREKPVTDSNKDE 177
           K +   +R+++  +++        +K    E + L  +KD++  +   +     +  K+ 
Sbjct: 721 KAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNA 780

Query: 178 EDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPEN------ 231
           +  EE R  E+ + ++  Q L IEE +   +K  QE     A LAS   S  E       
Sbjct: 781 QLLEEVRRREDSMADNS-QHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLAN 839

Query: 232 -NIKKLKELRSML-MEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRK 289
             I++ K+L  +L M+Q+  +A    K   ++L+EL               A K  KT++
Sbjct: 840 LRIERRKQLEEILEMKQEALLAAISEKDANIALLEL--------------SASKKKKTQE 885

Query: 290 ETQKLREFEEGLVSQYKFYLENLEQMVKD 318
           E   L+  ++ LV Q K   +N  +++ D
Sbjct: 886 EVMALKREKDRLVHQLKQQTQNRMKLMAD 914



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 103/524 (19%), Positives = 213/524 (40%), Gaps = 73/524 (13%)

Query: 8   KQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENP 67
           KQI  ++   K  K K++ +LK +  K++S L   + +   L     D      +  E+ 
Sbjct: 420 KQIEVYKSHSKFMKTKID-QLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESL 478

Query: 68  KEKRPGKRIEREEEEEEEALPLDMMDEDDL-----QLMKDLGQRVSFLTRDLSS-SEPVH 121
             K     I    + E +AL L + +++       + ++DL +    L  ++    + + 
Sbjct: 479 TAKEQRAAIL---QTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLE 535

Query: 122 AKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQ----------TREKPVT 171
            K+RK   +  K E +   L+   +K+L +L   KD+   +            T E+ ++
Sbjct: 536 VKERKINVLQKKIENLQEQLRDK-DKQLTNL---KDRVKSLQTDSSNTDTALATLEEALS 591

Query: 172 DSNK-----DEEDQEEERELEEEI---------IEDPIQELTIEEHLIERKKKLQEKKMH 217
           +  +      E+ + ++RE  EEI         +++ +  L  E  L E++  L + K H
Sbjct: 592 EKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAE--LTEKESSLIDLKEH 649

Query: 218 IAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSY--KI 275
            ++LASA L        KLK L   + ++  + +    +L     +E    + P +  +I
Sbjct: 650 ASSLASAGL----KRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQI 705

Query: 276 RPLTE-----AEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLKKSN-- 328
           + L +      ++  K + E  +L E  + + ++     + + ++ +    R +K  N  
Sbjct: 706 KQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAEL-ESLTLRHMKDQNKK 764

Query: 329 VVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDMSKLISEMCCEAVKKL 388
           V +LK  + L +     L E +         N+  + I  LMN + K   E+     +  
Sbjct: 765 VANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLA 824

Query: 389 FKQDKLG--QASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKK 446
             Q  L   +A L  +++     + +  E   EM +  L   I E +      +++  KK
Sbjct: 825 STQQSLAEKEAHLANLRI----ERRKQLEEILEMKQEALLAAISEKDANIALLELSASKK 880

Query: 447 FMTFKEKRKSLSRMQRKWKKAEEKLERELREAEASESTEKKLKL 490
             T +E            K+ +++L  +L+     + T+ ++KL
Sbjct: 881 KKTQEE--------VMALKREKDRLVHQLK-----QQTQNRMKL 911


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 121/540 (22%), Positives = 225/540 (41%), Gaps = 120/540 (22%)

Query: 8    KQIPSFRKLIKTSKVKLENKLKNKQFKQ--QSTLKKYRKEQRKLRQAV----KDAVSKKP 61
            K +   R  +KT K  LE  +K+ Q K+  + TL K ++ Q K  Q++    KD  + K 
Sbjct: 1345 KSLTKERDNLKTIKEALE--VKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKI 1402

Query: 62   IP-LENPKEKRPGK-RIEREE-------EEEEEALPLDMMDEDDLQLMKDLGQRVSFLTR 112
            +  +E  K K     RIE E        +E  + +     ++DDLQ ++++ Q       
Sbjct: 1403 VSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQ------- 1455

Query: 113  DLSSSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTD 172
              S S+ +   K   + I+ K+      L+T  E ++ H   +K++   I + R   V  
Sbjct: 1456 --SESDQL---KENIKEIVAKH------LETEEELKVAHCC-LKEQEETINELR---VNL 1500

Query: 173  SNKDEEDQEEERELE--EEIIEDPIQELTIEEHLI---------ERKKKLQEKKMHIAAL 221
            S K+ E    +++LE   + +++ IQE+  +E            E+  +L++ K H  A 
Sbjct: 1501 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK 1560

Query: 222  ASAILSDPENNIKKLKELRSMLMEQDPDVAVTVR-----------------------KLV 258
             SA+ S       K+ EL + L E   ++ + ++                       K +
Sbjct: 1561 DSALQSIES----KMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEI 1616

Query: 259  IVSLMELFKDITPSYKIRPLTEAEKST------KTRKETQKLR--EFEEGLVSQYKFYLE 310
            +  + E  +      K+  + E ++        K + ETQKL     E   +   +   E
Sbjct: 1617 VAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHE 1676

Query: 311  NLEQMVKDWKQRKLKKSNVVSLKAYK-----GLAEVAVKSLC---ELLVALPHFNFHNNI 362
            NLE+M    K+R   +S   +LK  +      L E   + L    EL +   H   H   
Sbjct: 1677 NLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQET 1736

Query: 363  IVLIVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLK 422
            I  +  ++++ +  IS M          Q  L  ++          +K ++ +++ E   
Sbjct: 1737 IDKLRGIVSEKTNEISNM----------QKDLEHSN--------DALKAQDLKIQEE--- 1775

Query: 423  TFLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERELREAEASE 482
                LRI  + +K+  E I+K +  ++  EK   LS MQ+  + +  KL+ +++E +A+E
Sbjct: 1776 ----LRIAHMHLKEQQETIDKLRGIVS--EKTDKLSNMQKDLENSNAKLQEKIQELKANE 1829



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 103/514 (20%), Positives = 218/514 (42%), Gaps = 47/514 (9%)

Query: 27   KLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEA 86
            +L+ K    Q  L K  +E   LR+ V      K +P E        +R+ +E +++ E 
Sbjct: 717  ELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEV-------ERLRKEIQDKSEE 769

Query: 87   LPLDMMDEDDL-QLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTAP 145
            L +   ++D L   +     RV  L  ++  ++   A  + + +  D+  +  +TL    
Sbjct: 770  LHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDF 829

Query: 146  EKELIHLLPIKDKSG--IIPQTREKPVTDSN----------KDEEDQEEERELEEEI--- 190
            E++   +L   ++    I+  ++E    DS+          K +E QE+ RE++E +   
Sbjct: 830  EQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEM 889

Query: 191  --IEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQD- 247
              +++ ++        +ER+K L  +K+         L+  ++++K+L+E  S+ +E+D 
Sbjct: 890  EQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQE--SLQIERDQ 947

Query: 248  --PDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQY 305
               D+  TV   + +   E  ++   S K    T     +K  +E  +    EE      
Sbjct: 948  LKSDIHDTVN--MNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETK 1005

Query: 306  KFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVL 365
                E  ++MV   K++ L+  N  +L A     E+ ++   ++   +      N +  +
Sbjct: 1006 D---EFQQKMVGIDKKQDLEAKNTQTLTADVKDNEI-IEQQRKIFSLIQE---KNELQQM 1058

Query: 366  IVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFL 425
            +  ++ +  +L +++       +  Q++L      + K      + +N+ ++ E   +  
Sbjct: 1059 LESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRT 1118

Query: 426  CLRIKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERELREAE------ 479
            C R+ EVE K   +     +K       ++ +S MQ+K  +  E L+ EL+  E      
Sbjct: 1119 CDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI-ENLKNELKNKELTLEHM 1177

Query: 480  ASESTEKKLKLHTETLNIVFVTYFR-ILKKAQRS 512
             +E  E   KL+     +  +T  R +LK+ Q+S
Sbjct: 1178 ETERLELAQKLNENYEEVKSITKERKVLKELQKS 1211



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 121/547 (22%), Positives = 232/547 (42%), Gaps = 65/547 (11%)

Query: 9    QIPSFRKLIKTSKVKLENKL-----KNKQF--KQQSTLK------KYRKEQRKLRQAVKD 55
            +I + +K ++    KL+NK+     K +QF  KQ S ++      K  KE RK + +   
Sbjct: 1506 EISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQ 1565

Query: 56   AVSKKPIPLENP-KEKRPGKRIEREEEEE----EEALPL--DMMDEDDLQLMKDL--GQR 106
            ++  K + L N  +E +   +I  +E+EE    +EAL +  D + E+  +++  +   Q 
Sbjct: 1566 SIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQE 1625

Query: 107  VSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTR 166
              +    +++      K  + E + +++E     L+   E E I L  I  ++    ++ 
Sbjct: 1626 KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENI-ETENIRLTQILHENLEEMRSV 1684

Query: 167  EKPVTDSNKDEEDQEEERE-LEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAI 225
             K   D    EE  + ER+ L+E + E   ++L  +E L      L+E +  I  L   I
Sbjct: 1685 TKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRG-I 1743

Query: 226  LSDPENNI----KKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEA 281
            +S+  N I    K L+     L  QD  +   +R    ++ M L +      K+R +  +
Sbjct: 1744 VSEKTNEISNMQKDLEHSNDALKAQDLKIQEELR----IAHMHLKEQQETIDKLRGIV-S 1798

Query: 282  EKSTKTRKETQKLREFEEGLVSQYKFYLENLEQMV---KDWKQRKLKKSNVVSLKAYKGL 338
            EK+ K     + L      L  + +    N  Q++   KD  + + K S +  LK     
Sbjct: 1799 EKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLK----- 1853

Query: 339  AEVAVKSLCELLVALPHFNFHN-NIIVLIVPLMNDMSKLISEMCCEAVKKLFKQDKLGQA 397
                 K + +  + L      N N+   +   + +M  ++ E   + ++++ +  KL + 
Sbjct: 1854 -----KQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKER--DNLRRVEETLKLERD 1906

Query: 398  SLGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKKFMTF--KEKRK 455
             L   K      K R+ E++ E+    +  +  +  V K  E I++    ++   K+  K
Sbjct: 1907 QL---KESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDK 1963

Query: 456  SLSRMQRKWKKAEEKLERELREAEASESTEKK------LKLHTETLNI----VFVTYFRI 505
            S   +Q+K ++ ++K  + LR  E    + KK      LK   E  N+    V +  F++
Sbjct: 1964 SKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQL 2023

Query: 506  LKKAQRS 512
             KK   S
Sbjct: 2024 TKKLHES 2030



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 89/494 (18%), Positives = 191/494 (38%), Gaps = 96/494 (19%)

Query: 20   SKVKLENKLKNKQFKQ-QSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIER 78
            +++++E    N++F++ Q  +K   KE+  L+  +K+A+  K   L+    +   K I+ 
Sbjct: 1324 ARIEMERLRLNEKFQESQEEIKSLTKERDNLK-TIKEALEVKHDQLKEHIRETLAK-IQE 1381

Query: 79   EEEEEEEALPLDMMDEDDLQLMKDLGQ---------RVSFLTRDLSSS-EPVHAKKRKHE 128
             + ++E++L +   D +  +++ ++ Q         R+      LS   +  H + +   
Sbjct: 1382 SQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVA 1441

Query: 129  RIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEE 188
            +  D  +++   LQ+  ++   ++  I  K     +T E+        +E +E   EL  
Sbjct: 1442 KEKDDLQRLQEVLQSESDQLKENIKEIVAKH---LETEEELKVAHCCLKEQEETINELRV 1498

Query: 189  EIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAI----LSDPENNIKKLKELRSMLM 244
             + E   +  TI++ L     KLQ K   I           +S+ +  + +LK+ +    
Sbjct: 1499 NLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRK 1558

Query: 245  EQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTR-KETQKLREFEEGLVS 303
             +D  +     K++ ++                L E+++  +   KE ++++  +E L  
Sbjct: 1559 AKDSALQSIESKMLELT--------------NRLQESQEEIQIMIKEKEEMKRVQEALQI 1604

Query: 304  QYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNII 363
            +     EN +++V   K+ + K+   + + A     E     +CE+              
Sbjct: 1605 ERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQE----KMCEI-------------- 1646

Query: 364  VLIVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKT 423
                               E +K+ F+  KL                  N E     L  
Sbjct: 1647 -------------------EHLKEQFETQKLNL---------------ENIETENIRLTQ 1672

Query: 424  FLCLRIKEVE-VKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERELREAEASE 482
             L   ++E+  V K+ +D+   ++  T K +R  L    R      E + R+L + E  +
Sbjct: 1673 ILHENLEEMRSVTKERDDLRSVEE--TLKVERDQLKENLR------ETITRDLEKQEELK 1724

Query: 483  STEKKLKLHTETLN 496
                 LK H ET++
Sbjct: 1725 IVHMHLKEHQETID 1738



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 115/514 (22%), Positives = 214/514 (41%), Gaps = 88/514 (17%)

Query: 19  TSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIER 78
           T+K        N+    ++ LK+YRKE   L++ +++      + LE            R
Sbjct: 325 TAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEE------VSLET-----------R 367

Query: 79  EEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSS------EPVHAK--------- 123
            +  E++ L   +++E DL L K   +++  LTR L +S      + + AK         
Sbjct: 368 AQAMEKDQL-AQLLEEKDL-LQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCL 425

Query: 124 ----KRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEED 179
               K K+    D++  IP  + T   K  I+LL   D+S            D+  + E 
Sbjct: 426 GKINKMKNSNYADQF-NIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEW 484

Query: 180 QEEERELEEEIIEDPIQELTIE-EHLIERKKKLQEKK--MHIAALASAILSDPENNIKKL 236
               + L +E IE  +  L  + ++L+   ++L+ +K  M +       L + E   +K 
Sbjct: 485 NPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKT 544

Query: 237 KELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKE---TQK 293
           K+ + M +  +      + K   V   +L  ++  S K+  L E E   K  +E   +QK
Sbjct: 545 KKDQEMQLIHEISNLKNLVKHAEVYNQDLENEL--SSKVELLREKEDQIKKLQEYIDSQK 602

Query: 294 LREFEEGLVSQYKFYLENLEQMVKDWKQRK--LKKSNVVSLKAYKGLAEVAVKSLCELLV 351
           L    E +     + LE++E    D KQ K  L  +  V+L A +  A +  ++L EL  
Sbjct: 603 L----ENIKMDLSYSLESIE----DPKQMKQTLFDAETVALDAKRESAFLRSENL-ELKE 653

Query: 352 ALPHFNFHNNIIVLIVPLMNDMSKLISEMCCEAVKKL-FKQDKLGQASLGVIKVISGFVK 410
            +        +      + ND+    S++  EA KK+    +K  Q++   I  ++  + 
Sbjct: 654 KM------KELATTYKQMENDIQLYQSQL--EAKKKMQVDLEKELQSAFNEITKLTSLID 705

Query: 411 GRNYEVRPEMLKTFLC-------LRIKEVEVKKDTEDINKPKKFMTFKEKRKSL-SRMQR 462
           G+       + K  LC       +   + E+ K+ E+    ++ +    + KSL S ++R
Sbjct: 706 GK-------VPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVER 758

Query: 463 KWKKAEEKLERELREAEASESTEKKLKLHTETLN 496
             K+ ++K E      E    T +K KL +E ++
Sbjct: 759 LRKEIQDKSE------ELHIITSEKDKLFSEVVH 786



 Score = 37.7 bits (86), Expect = 0.042
 Identities = 86/443 (19%), Positives = 196/443 (44%), Gaps = 60/443 (13%)

Query: 38   TLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDL 97
            +LK++++    L+  + + VS+     EN  E +        +E +++ + +D   + DL
Sbjct: 972  SLKQHQETINTLKSKISEEVSRNLHMEENTGETK--------DEFQQKMVGIDK--KQDL 1021

Query: 98   QLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKD 157
            +      +    LT D+  +E +  +++    I +K E          EKE +    +K+
Sbjct: 1022 E-----AKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKT-DLKE 1075

Query: 158  KSGIIPQTRE--KPVTDSNKDEED---QEEEREL--EEEIIEDPIQELTIEEHLIERKKK 210
               +  + +E  + + D  K +++   QE+   +  E E+     +   +EE L E+ ++
Sbjct: 1076 NIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQ 1135

Query: 211  LQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDIT 270
            LQEK+  +  +    +S+ +  I +++ L++ L  ++    +T+  +    L EL + + 
Sbjct: 1136 LQEKQQQLLNVQEE-MSEMQKKINEIENLKNELKNKE----LTLEHMETERL-ELAQKLN 1189

Query: 271  PSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVV 330
             +Y+     E +  TK RK  ++L++  E      + Y+  +E      K+ +LK +++ 
Sbjct: 1190 ENYE-----EVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE-ELKIAHI- 1242

Query: 331  SLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDMSKLISEMCCEAVKKLFK 390
             LK ++   +   +S+ E    + +                D+ K  +++  E +  L +
Sbjct: 1243 HLKEHQETIDELRRSVSEKTAQIIN--------------TQDLEKSHTKLQ-EEIPVLHE 1287

Query: 391  QDKLGQASLGVIKVISGFVKGRN-YEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKKFMT 449
            + +L    L  +K +S   +  N  E+  E   T     +  +E+++    +   +KF  
Sbjct: 1288 EQEL----LPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMER----LRLNEKFQE 1339

Query: 450  FKEKRKSLSRMQRKWKKAEEKLE 472
             +E+ KSL++ +   K  +E LE
Sbjct: 1340 SQEEIKSLTKERDNLKTIKEALE 1362



 Score = 34.3 bits (77), Expect = 0.47
 Identities = 67/298 (22%), Positives = 115/298 (38%), Gaps = 71/298 (23%)

Query: 81   EEEEEALPLDMMDEDDLQLMKDLGQRV----SFLTRDLSSSEPV----------HAKKRK 126
            E EE +  +    E DL+ +K+  +++      L   L+S   V          H   R 
Sbjct: 2316 EFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRA 2375

Query: 127  HERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVT------------DSN 174
             +   +K  ++  +L  A E  +        +S II   +E  VT            +SN
Sbjct: 2376 TQLTTEKIRELENSLHEAKESAM------HKESKIIKMQKELEVTNDIIAKLQAKVHESN 2429

Query: 175  KDEEDQEEERELEEEII-------EDPIQELTIEEHLI--ERKKKLQEKKMHIAALASAI 225
            K  E  +E  ++ ++ +       ++ I++L ++   I  E+ K  +E +  I+A  + +
Sbjct: 2430 KCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATV 2489

Query: 226  LSDPENNIKKLKE-LRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYK---------- 274
                E  I+ L+E LR     QD             S++    D  PS K          
Sbjct: 2490 EYQKEV-IRLLRENLRRSQQAQD------------TSVISEHTDPQPSNKPLTCGGGSGI 2536

Query: 275  ---IRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLEN---LEQMVKDWKQRKLKK 326
                + L    +  +  KE  KL++  E L+ Q    L N   L   VK WK+R LK+
Sbjct: 2537 VQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKR 2594


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 118/523 (22%), Positives = 214/523 (40%), Gaps = 59/523 (11%)

Query: 25   ENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEE 84
            E ++  +Q   Q   K  R  +++ R   K A  ++ +  E  K  +  +++ +EE +  
Sbjct: 1558 EQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLA 1617

Query: 85   EA-LPLDMMDEDDLQLMKDLGQRVSFLT-RDLSSSEPVHAKKRKHERIIDKYEKIPRTLQ 142
            +A + +   D +  Q      Q+   L  R    S+      +K +++  K+EK+ R  +
Sbjct: 1618 QAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEE 1677

Query: 143  TAPEK-----ELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQE 197
               +K     E+ ++L  K +   +PQ RE+ +    K+   + EE E + E +    +E
Sbjct: 1678 KLAKKGGKLAEVKNILAQKVEE--LPQ-REQNLDWQEKELAQELEELEWDMEELSWKEEE 1734

Query: 198  LTIEE-HLIERKKKLQEKKMHIAALASAILSDPENNIKKLKEL----------------- 239
            L  EE  L+E KKKL E++  +A      LS+ E  + + +EL                 
Sbjct: 1735 LNQEEGKLVEEKKKLAEEEEALAWQREK-LSEEETKLAQEEELLIQEKEKLAQHKEKMPE 1793

Query: 240  --------RSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKET 291
                    R  L+E+   +A   R+  I S+ EL K+    Y+ + L + +K+    KE 
Sbjct: 1794 EEERLGRKREQLIEKKMKLA-QKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKE- 1851

Query: 292  QKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLA---EVAVKSLCE 348
             KL + +E L+   +    + +Q+V+   + KL   N +  +  + L    E  +K   +
Sbjct: 1852 -KLAQRKENLLYNKERLTHSKKQLVQ--VKNKLGMFNKILAQVEEKLTQEKETVIKKKEK 1908

Query: 349  LLVALPHFNFHNNIIVLIVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGF 408
            L            ++ +   L     KL  E    A++K   Q   G+  L     I+  
Sbjct: 1909 LA------ETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQ---GKKRLRGELDIAKE 1959

Query: 409  VKGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAE 468
             K  N E++    +    +  KE   K +T + ++ +K    +++       +RK    E
Sbjct: 1960 EKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQE-----LFERKLSLEE 2014

Query: 469  EKLERELREAEASESTEKKLKLHTETLNIVFVTYFRILKKAQR 511
            + L  E R     ES   K KL       +FV   R L KA R
Sbjct: 2015 KILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASR 2057



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 60/261 (22%), Positives = 110/261 (42%), Gaps = 49/261 (18%)

Query: 14   RKLIKTSKVKLEN-KLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKE--- 69
            R  I+ SK+ ++      K+ +     KK  ++QRKL   ++  ++K+    E   +   
Sbjct: 2110 RLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLAR 2169

Query: 70   KRPGKRIEREEE---EEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRK 126
            K     ++ EEE   EEEE +P                    FL R          +KRK
Sbjct: 2170 KHSEVILDDEEEGGIEEEEVIP--------------------FLKR--------RWRKRK 2201

Query: 127  HERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEEREL 186
              +  DK    P+   ++   E+       ++   +    EK  + S+++EE++EEE E 
Sbjct: 2202 EAKRGDK----PKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEER 2257

Query: 187  EEEII---------EDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLK 237
            EEE +         E+  +E  +E+   E+KKK +EKK         +  + E  I   +
Sbjct: 2258 EEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKE-EIMSEE 2316

Query: 238  ELRSMLMEQDPDVAVTVRKLV 258
            E  S+  E++ + + ++ + V
Sbjct: 2317 ETESLSDEEEEEESCSLEEEV 2337



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 102/521 (19%), Positives = 215/521 (41%), Gaps = 76/521 (14%)

Query: 12   SFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAV-KDAVSKKPIPLENPKEK 70
            +  K +   K +L  +L   + ++   L+  R  + K+R    K+ +SK     E P+  
Sbjct: 1938 ALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKG----ETPETS 1993

Query: 71   RPGKRIEREEEEEEEALPLD---MMDEDDLQLMKDL-----------GQRVSFL-TRDLS 115
            R  K  + E+E  E  L L+   ++ ED +  M++            GQR+     R L+
Sbjct: 1994 RQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLA 2053

Query: 116  SSEPVHAKKRKH-ERIIDKYEKIPRTLQ--TAPEKELIH--LLPIKDKSGIIPQTREKPV 170
             +     KKR+   +   K  KI + LQ  T  E++L    +   K K  +  + R   +
Sbjct: 2054 KASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSI 2113

Query: 171  TDSNKDEED---QEEEREL---EEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASA 224
              S  D ++    E+  EL   E+++     +       +I +++K+ E++  +A   S 
Sbjct: 2114 EQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSE 2173

Query: 225  ILSDPENN---------------IKKLKELR----------SMLMEQDPDVAVTVRKLVI 259
            ++ D E                  +K KE +          S + E + +   +     +
Sbjct: 2174 VILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESL 2233

Query: 260  VSLMELFKDITPSYKIRPLTEAEKSTK-TRKETQKLREFEEGLVSQYKFYLENLEQMVKD 318
            +  +E  + ++   +     E E+  +  R+E ++ +E EEG   Q +   E  ++  K+
Sbjct: 2234 LDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKE 2293

Query: 319  WKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDMSKLIS 378
             K+ ++++   V  +  + ++E   +SL +        +    +         D  K I 
Sbjct: 2294 KKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEV---------DREKEIL 2344

Query: 379  EMCCEAVKKLFKQDKLGQASL----GVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEV 434
            +      +K FK  +  + SL     V+ ++ G   G+   +R  +LK+ L   +     
Sbjct: 2345 KK-----EKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALE 2399

Query: 435  KKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLEREL 475
             K+   +  P+K +++++K+ ++  + RK+    +K ERE+
Sbjct: 2400 MKEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDK-EREV 2439



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 67/348 (19%), Positives = 143/348 (41%), Gaps = 32/348 (9%)

Query: 7    KKQIPSFRKLIKTSKVKLENKLKNKQF-KQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLE 65
            KK +   +K +   K KL  + +N  + K++ T  K +  Q K +  + + +  +   +E
Sbjct: 1836 KKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQ---VE 1892

Query: 66   NPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKR 125
                +     I+++E+  E    L  +++   +  + L Q    L  + +    V  KKR
Sbjct: 1893 EKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAM---VQGKKR 1949

Query: 126  -KHERIIDKYEKIPRTLQTAPEKELIHLLPIKD--KSGIIPQT-REKPVTDSNKDEEDQE 181
             + E  I K EK          +E + L+  K+    G  P+T R++ +T    ++E  E
Sbjct: 1950 LRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQV--EQELFE 2007

Query: 182  EERELEEEIIEDPIQELTIEEH---------------LIERKKKLQEKKMHIAALASAIL 226
             +  LEE+I+    + L +EE                 ++ ++KL +    +     ++ 
Sbjct: 2008 RKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLS 2067

Query: 227  SDPENNIKKLKELRSMLMEQ----DPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAE 282
             +P    K LK L+ +  ++      ++ +T  K  +               I+    +E
Sbjct: 2068 KEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSE 2127

Query: 283  KSTKTRKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVV 330
            K ++  K+ +KL   +  L ++ +  +   E+M ++  +   K S V+
Sbjct: 2128 KRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVI 2175



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 37/138 (26%), Positives = 63/138 (45%), Gaps = 29/138 (21%)

Query: 74   KRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDK 133
            K +   EEE+ +    DM+  ++ Q++   G++V FL       EP +    K   I  K
Sbjct: 1340 KEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFL-------EPGNVTMGK--EISKK 1390

Query: 134  YEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIED 193
             EK  +T Q +P            K G     +E+ V    +  E  +EER++ EE+ E 
Sbjct: 1391 EEK--KTFQKSP------------KQGRKAVQKERKVGKIKR--EMTKEERDMSEEVEE- 1433

Query: 194  PIQELTIEEHLIERKKKL 211
                 T+EE +++++ KL
Sbjct: 1434 ---MATLEEKVVKQEGKL 1448


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 63/257 (24%), Positives = 118/257 (45%), Gaps = 34/257 (13%)

Query: 77   EREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEK 136
            EREEEEE E    ++M+E +  ++++   ++  +++ + + EP    +R+ ++I+ K  K
Sbjct: 9513 EREEEEEAEVTEYEVMEEPEEYVVEE---KLHIISKRVEA-EPAEVTERQEKKIVLK-PK 9567

Query: 137  IPRTLQT-------------APEKELIHLLPIKDK--SGIIPQTREKPVTDSNKDEEDQE 181
            IP  ++               PEK++   +P K+K     +P+  +KPV +     +  +
Sbjct: 9568 IPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIK 9627

Query: 182  EERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRS 241
             E  L  ++ E  +Q    E+ L+   KK    K  +       +  PE  + KLK  R 
Sbjct: 9628 MEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAV--PEEKVLKLKPKR- 9684

Query: 242  MLMEQDPDVAVT-VRKLVI----VSLMELFKDITPSYKIRPLTEAEKSTKTRKE---TQK 293
               E++P   VT  RK V+    VS+    ++  P  ++  + E E++    +E    Q+
Sbjct: 9685 ---EEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQR 9741

Query: 294  LREFEEGLVSQYKFYLE 310
              E+EE     YK + E
Sbjct: 9742 EEEYEEYEEYDYKEFEE 9758



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 52/224 (23%), Positives = 99/224 (44%), Gaps = 18/224 (8%)

Query: 40    KKYRKEQRKLRQAVKDAVSKKPIPLENPK--EKRPGKRIEREEE---EEEEALPLDMMDE 94
             KK      K+ +  K  V +K +P+  PK  E  P K  E  ++   EE++  P+    E
Sbjct: 10023 KKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVE 10082

Query: 95    DDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLP 154
                  +    + V      +  + P   +    E I+ + E +P   +  PE+E +    
Sbjct: 10083 APPPKVPKKREPVP-----VPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEV---- 10133

Query: 155   IKDKSGIIPQTREKPVTDSNKDEEDQ----EEERELEEEIIEDPIQELTIEEHLIERKKK 210
             + ++  ++P+  E P  +     E++    EEE   EEE++ +   ++ +   + E KKK
Sbjct: 10134 LPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKK 10193

Query: 211   LQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTV 254
             + EKK+ I     A  +      KK++E R +L +++  + V V
Sbjct: 10194 VTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEV 10237



 Score = 38.5 bits (88), Expect = 0.025
 Identities = 60/301 (19%), Positives = 117/301 (38%), Gaps = 38/301 (12%)

Query: 10    IPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYR-------KEQRKLRQAVKDAVSKKPI 62
             +P  +K +   KV +  K +    K     KK         KE+  L   V +   ++PI
Sbjct: 10187 VPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPI 10246

Query: 63    PLENPKEKRPGKRIEREEEEEEEALP---LDMMDEDDLQLMKDLGQRVSFLTRDLSSSE- 118
               E   E+ P   IE  EE     +P      + E    + K +    + +++ +   + 
Sbjct: 10247 SEEEIPEEPPS--IEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKV 10304

Query: 119   --PVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSG-------------IIP 163
               PV  K+    ++ +  +K+P      P+KE +   P K ++              ++ 
Sbjct: 10305 PVPVQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVP--PAKGRTVLEEKVSVAFRQEVVVK 10362

Query: 164   QTREKPVTDSNKDEEDQEEE-RELEEEIIEDPIQE----LTIEEHLIERKKKLQEKKMHI 218
             +  E  V ++  +E  +EEE  E+EE   E    E    + +E+H +E + ++++    I
Sbjct: 10363 ERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVI 10422

Query: 219   AALAS---AILSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKI 275
                 +    +   P+   K  +    ++  + P   V  RK     + E+ K I    K+
Sbjct: 10423 EVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKV 10482

Query: 276   R 276
             R
Sbjct: 10483 R 10483



 Score = 37.4 bits (85), Expect = 0.055
 Identities = 65/295 (22%), Positives = 114/295 (38%), Gaps = 34/295 (11%)

Query: 14    RKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPG 73
             ++++   KV +  K +    K     KK   E++      + A S  P   E P+E  P 
Sbjct: 10754 KEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPE 10813

Query: 74    KRIEREE-------EEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRK 126
             + I  EE       EEEE  +P   + E+  +++ +    V      +   E    K+ +
Sbjct: 10814 EEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPV------IKKPEAPPPKEPE 10867

Query: 127   HERIIDKYEKIPRTLQTAPE------KELIHLLPI--KDKSGIIPQTREKPVTDSNKDEE 178
              E++I+K +  PR     P       KE I  L    K K    PQ  EK      K   
Sbjct: 10868 PEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPG 10927

Query: 179   DQEEERELEEEIIEDPIQELTIEEHLIER----KKKLQEKKMHIAALASAILSDPENNIK 234
              +++ R+L  E   +P +E+ ++  L +R    + K++ KK+      +     P   ++
Sbjct: 10928 GEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVE 10987

Query: 235   KLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRK 289
             ++         + P V    RK+   + +   K   P     P  + E   KT K
Sbjct: 10988 EV---------EVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIK 11033



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 56/267 (20%), Positives = 112/267 (41%), Gaps = 27/267 (10%)

Query: 46   QRKLRQAVKDAVSKKPIPLENPKEKRPGKR--IEREEEE-----EEEALPLDMMDEDDLQ 98
            + K+    +   S  P   E PK+K P +R  + R+EEE     +  ALP   + E+ + 
Sbjct: 9382 EEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVA 9441

Query: 99   LMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDK 158
            +   + ++      ++S    V  K+   E  +     +P+ ++        H +  +++
Sbjct: 9442 VPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSF--AVPQRVEVTR-----HEVSAEEE 9494

Query: 159  SGIIPQTREKPVTDSNKDEEDQEEERELEE-EIIEDPIQELTIEEHLIERKKKLQEKKMH 217
                 +     ++   ++E ++EEE E+ E E++E+P      EE+++E K  +  K+  
Sbjct: 9495 WSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEP------EEYVVEEKLHIISKR-- 9546

Query: 218  IAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRP 277
            + A  + +    E  I  LK      +E+ P   V      IV   ++   +    K+ P
Sbjct: 9547 VEAEPAEVTERQEKKI-VLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPP 9605

Query: 278  ---LTEAEKSTKTRKETQKLREFEEGL 301
                 E +K    +K   K+ + EE L
Sbjct: 9606 PKVPEEPKKPVPEKKVPPKVIKMEEPL 9632



 Score = 34.7 bits (78), Expect = 0.36
 Identities = 60/319 (18%), Positives = 125/319 (39%), Gaps = 42/319 (13%)

Query: 3    ARRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPI 62
            A+  +K+ P   K+IK   ++   K   +  +++  + K  +  +K+   V    S+ P+
Sbjct: 9167 AKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKI---VPQKPSRTPV 9223

Query: 63   PLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHA 122
              E  + K P    ++    EE+       +E+       +   V  + +++ + E +H 
Sbjct: 9224 QEEVIEVKVPAVHTKKMVISEEKMFFASHTEEE-------VSVTVPEVQKEIVTEEKIHV 9276

Query: 123  KKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDK----SGIIPQTREKPVTDSNKDEE 178
               K    ++   K+P  L   P  E +  +PI  K    +  +P+  +KPV +  K   
Sbjct: 9277 AISKR---VEPPPKVPE-LPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVP 9332

Query: 179  DQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSD---------- 228
              ++E     ++ E P + +  E+  +   KK +     +  +   ++++          
Sbjct: 9333 VPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQRE 9392

Query: 229  -------PENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIR-PLTE 280
                   PE   KK+ E R  +  ++ +V    +      +  L K   P  K+  P+  
Sbjct: 9393 ESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPK------VPALPKKPVPEEKVAVPVPV 9446

Query: 281  AEKSTKTRKETQKLREFEE 299
            A+K+   R E  K    EE
Sbjct: 9447 AKKAPPPRAEVSKKTVVEE 9465


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 66/304 (21%), Positives = 129/304 (42%), Gaps = 18/304 (5%)

Query: 21  KVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREE 80
           K++ + K + ++ K     +K R+++ K+R+  K    ++    E  K +   KR E+EE
Sbjct: 418 KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEE 477

Query: 81  ---------EEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERII 131
                    E+EE     + M E + ++ K   Q      ++    E     + + E++ 
Sbjct: 478 MWRQEEKIHEQEEIWRQKEKMHEQEEKIRK---QEEKVWRQEEKIREQEEKIREQEEKMW 534

Query: 132 DKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEII 191
            + EKI    +   E+E +H      +     +  +K      K  E +E+    EE+I 
Sbjct: 535 RQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIR 594

Query: 192 EDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVA 251
           E   +    EE + ++++K++E++  I      I    E    K++E   M  EQ+  + 
Sbjct: 595 EQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEE----KIREQEEMTQEQEEKMG 650

Query: 252 VTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLEN 311
               K+         ++ T   +   + E EK  K R++ +K+RE EE +  Q +   E 
Sbjct: 651 EQEEKMCEQEEKMQEQEETMWRQEEKIREQEK--KIREQEEKIREQEEMMQEQEEKMWEQ 708

Query: 312 LEQM 315
            E+M
Sbjct: 709 EEKM 712



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 63/341 (18%), Positives = 143/341 (41%), Gaps = 48/341 (14%)

Query: 2   KARRNKKQIPSFRKLIKTSKVKL----------ENKLKNKQFKQQSTLKKYRKEQRKLRQ 51
           K  R +++I  + + I+  + K+          E K++ ++       +K R+++  + +
Sbjct: 301 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360

Query: 52  AVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLT 111
             +    ++ +  E  ++ R  + +  E+EE+   L   M +++ ++  ++  Q    + 
Sbjct: 361 KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR 420

Query: 112 RDLSSSEPVHAKKRKHERIIDKYEKI-PRTLQTAPEKELIHLLPIKDKSGIIPQTREKPV 170
                 E      R+ E+I ++ EKI  +  +   ++E IH                   
Sbjct: 421 EQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH------------------- 461

Query: 171 TDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPE 230
               + E+ +EEE+  E+E +    +++  +E +  +K+K+ E++  I      +    E
Sbjct: 462 ----EQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEE 517

Query: 231 NNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEK----STK 286
               K++E    + EQ+  +     K  I    E++++    ++   + E EK      K
Sbjct: 518 ----KIREQEEKIREQEEKMWRQEEK--IREQEEMWREEEKMHEQEKIWEEEKRQEQEDK 571

Query: 287 TRKETQKLREFEEGLVSQYKFYLE----NLEQMVKDWKQRK 323
             ++ +K+RE EE +  Q +   E      EQ  K WKQ +
Sbjct: 572 MWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEE 612



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 53/256 (20%), Positives = 106/256 (41%), Gaps = 28/256 (10%)

Query: 2   KARRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKL-RQAVKDAVSKK 60
           K R  +K+        +  K+  + ++  ++ K     +K RK++ K+ RQ  K    ++
Sbjct: 465 KIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEE 524

Query: 61  PIPLENPKEKRPGKRIEREEE---EEEEALPLDMM-DEDDLQLMKDLGQRVSFLTRDLSS 116
            I  +  K  R  ++I  +EE   EEE+    + + +E+  Q  +D   R     R+   
Sbjct: 525 KIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEE 584

Query: 117 S-----EPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVT 171
                 E +  ++ K +   +K  K    ++   EK       I+++   I +  E    
Sbjct: 585 KVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQE 644

Query: 172 DSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPEN 231
              K  E +E+  E EE++ E        EE + E++KK++E++                
Sbjct: 645 QEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQE---------------- 688

Query: 232 NIKKLKELRSMLMEQD 247
             +K++E   M+ EQ+
Sbjct: 689 --EKIREQEEMMQEQE 702



 Score = 36.6 bits (83), Expect = 0.095
 Identities = 38/189 (20%), Positives = 86/189 (45%), Gaps = 29/189 (15%)

Query: 25  ENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEE 84
           E K++ ++ K+Q   +K  K++ K+R+                +E++  ++ E+  E+EE
Sbjct: 590 EEKIREQEEKRQEQEEKMWKQEEKIRE----------------QEEKIQEQEEKIREQEE 633

Query: 85  EALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTA 144
           +    + M ++  + M +  Q      ++    E      R+ E+I ++ +KI    +  
Sbjct: 634 KIREQEEMTQEQEEKMGE--QEEKMCEQEEKMQEQEETMWRQEEKIREQEKKI----REQ 687

Query: 145 PEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHL 204
            EK       I+++  ++ +  EK      K  E +E+ +E EE++     +    E  L
Sbjct: 688 EEK-------IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 740

Query: 205 IERKKKLQE 213
            ++++K+QE
Sbjct: 741 RQQEEKMQE 749



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 40/194 (20%), Positives = 79/194 (40%), Gaps = 26/194 (13%)

Query: 159 SGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHI 218
           +G + Q      T   K +   EE  +  + +  +  +    +E L E+  KLQEK   +
Sbjct: 174 AGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLV 233

Query: 219 AALASAILSDPENNIKKLKELRSMLMEQDPDV----------AVTVRKLVIVSLMELFKD 268
            +  S I  + +   +KL+  + +L +Q              +V+ +    V   EL+  
Sbjct: 234 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 293

Query: 269 ITPSYKIRPLTEAEK-----------STKTRKETQKLREFEEGLVSQYKFYLENLEQMVK 317
           +    + +   + EK             K R++ +K+RE EE +  Q +   E  E+M +
Sbjct: 294 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 353

Query: 318 D----W-KQRKLKK 326
                W K+ K+++
Sbjct: 354 QEEMMWEKEEKMRR 367



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 60/293 (20%), Positives = 122/293 (41%), Gaps = 46/293 (15%)

Query: 35  QQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEALPLDMMDE 94
           Q+    +Y +E  K R A+   + +  I  E  KEK           + +E L L   ++
Sbjct: 187 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA---------KLQEKLQLVESEK 237

Query: 95  DDLQLMKDLGQRVSFLTRDLSSSE---PVHAKKRKHERIIDKYEKIPRTLQT-APEKELI 150
            ++QL       V  L R L  ++   P    + + + +  + + +   LQ    E EL 
Sbjct: 238 SEIQL------NVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 291

Query: 151 HLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKK 210
           + L          Q +E+ +    +  ++ EE+ + +EE I +  +++  +E  + R+++
Sbjct: 292 NRLN---------QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEE 342

Query: 211 LQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDIT 270
           +  +K         ++ + E  +++ +E   M+ E++        K+     M   K+  
Sbjct: 343 MMWEKEEKMRRQEEMMWEKEEKMRRQEE---MMWEKE-------EKMRRQEEMMWEKE-- 390

Query: 271 PSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRK 323
              KIR L E     +  +E ++ R+ EE +  Q K      EQ  K W+Q +
Sbjct: 391 --EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK----RQEQEAKMWRQEE 437



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 36/195 (18%), Positives = 91/195 (46%), Gaps = 23/195 (11%)

Query: 21  KVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREE 80
           K+  + K+  ++ +Q+   K +R+E++   Q  K  V ++   +   +EKR  +  +  +
Sbjct: 552 KMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEK--VWRQEEKIREQEEKRQEQEEKMWK 609

Query: 81  EEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRT 140
           +EE+     + + E + ++ +   Q      ++  + E       + E++ ++ EK+   
Sbjct: 610 QEEKIREQEEKIQEQEEKIRE---QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ 666

Query: 141 LQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTI 200
            +T   +E        +K     + +EK + +  +   +QEE  + +EE + +       
Sbjct: 667 EETMWRQE--------EKI----REQEKKIREQEEKIREQEEMMQEQEEKMWEQ------ 708

Query: 201 EEHLIERKKKLQEKK 215
           EE + E+++K+QE++
Sbjct: 709 EEKMCEQEEKMQEQE 723


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 71/314 (22%), Positives = 134/314 (42%), Gaps = 45/314 (14%)

Query: 25  ENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEE 84
           + +LK K  + Q  L+    E+ +++  VKD                    ++R+ E  +
Sbjct: 213 DEELKEKNAELQEKLRLVESEKSEIQLNVKD--------------------LKRKLERAQ 252

Query: 85  EALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTA 144
             LP   +  +  +L K+L    + L   +  +E  +   ++ E  + + E+    +Q  
Sbjct: 253 LLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEE---KIQEQ 309

Query: 145 PEKELIHLLPIKDKSGIIPQTREKPVTDSNK--DEED-----QEEERELEEEIIEDPIQE 197
            EK     L I+++   + +  EK      K  ++ED     +E+ RE EE+I E   + 
Sbjct: 310 EEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKM 369

Query: 198 LTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKL 257
              EE + E+ +K+QE++  +      I    E   +K+      + EQD  +     ++
Sbjct: 370 WRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEM 429

Query: 258 -----VIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENL 312
                 I  L E+ +D     K+R + E     K ++E +K++E EE +  Q +   +  
Sbjct: 430 WRQEEKIRELEEMMQD--QEEKLREVEE-----KMQEEEEKMQEQEEKIQRQEE---KIQ 479

Query: 313 EQMVKDWKQRKLKK 326
           EQ  K W+Q KL K
Sbjct: 480 EQEEKTWRQEKLLK 493



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 45/227 (19%), Positives = 110/227 (48%), Gaps = 16/227 (7%)

Query: 2   KARRNKKQIPSFRKLIKTSKVKL---ENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVS 58
           K  R +++I    + I+  + K+   E K++ +  K Q   ++  +++ K+R+  ++   
Sbjct: 347 KMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE--QEEKR 404

Query: 59  KKPIPLENPKEKRPGKRIEREEEE----EEEALPLDMMDEDDLQLMKDLGQRVSFLTRDL 114
           ++ +  +  K +   ++I  +EEE    EE+   L+ M +D  + ++++ +++      +
Sbjct: 405 QEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKM 464

Query: 115 SSSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSN 174
              E     +R+ E+I ++ EK  R  +   ++E I      ++   + +  EK      
Sbjct: 465 QEQE--EKIQRQEEKIQEQEEKTWRQEKLLKQEEKIW-----EQEEKMWRQEEKMWEQEE 517

Query: 175 KDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAAL 221
           K +E +E+ +  EE++ E  ++    EE + E++ +LQE +  +  L
Sbjct: 518 KMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKL 564



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 42/195 (21%), Positives = 93/195 (47%), Gaps = 16/195 (8%)

Query: 25  ENKLKNKQFKQQSTLKKYRKEQRKL-RQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEE 83
           E K+  ++ K     +K R+++ K+ RQ  K    ++ I  +  K  R  ++I  ++E+ 
Sbjct: 324 EEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKI 383

Query: 84  EEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQT 143
           +E        E+ ++  ++  +R   + R          K R+ E  + + E+  R L+ 
Sbjct: 384 QEQEEEMWRQEEKIREQEE--KRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEE 441

Query: 144 APEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEH 203
                      ++D+   + +  EK   +  K +E QEE+ + +EE I++  ++   +E 
Sbjct: 442 M----------MQDQEEKLREVEEKMQEEEEKMQE-QEEKIQRQEEKIQEQEEKTWRQEK 490

Query: 204 LIERKKKL--QEKKM 216
           L+++++K+  QE+KM
Sbjct: 491 LLKQEEKIWEQEEKM 505


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 71/314 (22%), Positives = 134/314 (42%), Gaps = 45/314 (14%)

Query: 25  ENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEE 84
           + +LK K  + Q  L+    E+ +++  VKD                    ++R+ E  +
Sbjct: 213 DEELKEKNAELQEKLRLVESEKSEIQLNVKD--------------------LKRKLERAQ 252

Query: 85  EALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTA 144
             LP   +  +  +L K+L    + L   +  +E  +   ++ E  + + E+    +Q  
Sbjct: 253 LLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEE---KIQEQ 309

Query: 145 PEKELIHLLPIKDKSGIIPQTREKPVTDSNK--DEED-----QEEERELEEEIIEDPIQE 197
            EK     L I+++   + +  EK      K  ++ED     +E+ RE EE+I E   + 
Sbjct: 310 EEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKM 369

Query: 198 LTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKL 257
              EE + E+ +K+QE++  +      I    E   +K+      + EQD  +     ++
Sbjct: 370 WRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEM 429

Query: 258 -----VIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENL 312
                 I  L E+ +D     K+R + E     K ++E +K++E EE +  Q +   +  
Sbjct: 430 WRQEEKIRELEEMMQD--QEEKLREVEE-----KMQEEEEKMQEQEEKIQRQEE---KIQ 479

Query: 313 EQMVKDWKQRKLKK 326
           EQ  K W+Q KL K
Sbjct: 480 EQEEKTWRQEKLLK 493



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 45/227 (19%), Positives = 110/227 (48%), Gaps = 16/227 (7%)

Query: 2   KARRNKKQIPSFRKLIKTSKVKL---ENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVS 58
           K  R +++I    + I+  + K+   E K++ +  K Q   ++  +++ K+R+  ++   
Sbjct: 347 KMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE--QEEKR 404

Query: 59  KKPIPLENPKEKRPGKRIEREEEE----EEEALPLDMMDEDDLQLMKDLGQRVSFLTRDL 114
           ++ +  +  K +   ++I  +EEE    EE+   L+ M +D  + ++++ +++      +
Sbjct: 405 QEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKM 464

Query: 115 SSSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSN 174
              E     +R+ E+I ++ EK  R  +   ++E I      ++   + +  EK      
Sbjct: 465 QEQE--EKIQRQEEKIQEQEEKTWRQEKLLKQEEKIW-----EQEEKMWRQEEKMWEQEE 517

Query: 175 KDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAAL 221
           K +E +E+ +  EE++ E  ++    EE + E++ +LQE +  +  L
Sbjct: 518 KMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKL 564



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 42/195 (21%), Positives = 93/195 (47%), Gaps = 16/195 (8%)

Query: 25  ENKLKNKQFKQQSTLKKYRKEQRKL-RQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEE 83
           E K+  ++ K     +K R+++ K+ RQ  K    ++ I  +  K  R  ++I  ++E+ 
Sbjct: 324 EEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKI 383

Query: 84  EEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQT 143
           +E        E+ ++  ++  +R   + R          K R+ E  + + E+  R L+ 
Sbjct: 384 QEQEEEMWRQEEKIREQEE--KRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEE 441

Query: 144 APEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEH 203
                      ++D+   + +  EK   +  K +E QEE+ + +EE I++  ++   +E 
Sbjct: 442 M----------MQDQEEKLREVEEKMQEEEEKMQE-QEEKIQRQEEKIQEQEEKTWRQEK 490

Query: 204 LIERKKKL--QEKKM 216
           L+++++K+  QE+KM
Sbjct: 491 LLKQEEKIWEQEEKM 505


>gi|100814339 coiled-coil domain containing 146 [Homo sapiens]
          Length = 955

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 96/464 (20%), Positives = 199/464 (42%), Gaps = 52/464 (11%)

Query: 7   KKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAV--KDAVSKK---P 61
           ++     RK I   K++++N  ++   KQ+  LK+ ++ +  L   V  KD V+     P
Sbjct: 179 RESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIP 238

Query: 62  IPLENPKEKRPGKRIEREEEE---EEEALPL-DMMDEDDLQLMKDLGQRVSFLTRDLSSS 117
           + +    EK   K++E E+++   E+E   L D + + + ++   + ++ + +       
Sbjct: 239 VQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKR 298

Query: 118 EPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIP-QTREKPVTDSNKD 176
             +  K+R+H +++       + L+ A E E   L     + GI+    R   +   N  
Sbjct: 299 ALLEIKEREHNQLV-------KLLELARENEATSLT----ERGILDLNLRNSLIDKQNYH 347

Query: 177 EEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKL 236
           +E   ++RE E +       EL ++    +  ++ Q     +     AI  D     ++ 
Sbjct: 348 DELSRKQREKERDFRNLRKMELLLKVSW-DALRQTQALHQRLLLEMEAIPKDDSTLSERR 406

Query: 237 KELRSMLMEQDPDVAVTVRKLV---IVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQK 293
           +EL         +V V  R L    I+S ME         K+     AE++ K  KE + 
Sbjct: 407 RELHK-------EVEVAKRNLAQQKIISEMES--------KLVEQQLAEEN-KLLKEQEN 450

Query: 294 LREFEEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVV-SLKAYKGLAEVAVKSLCELLVA 352
           ++E    L+   +  ++  EQ  KD+ + + K +N+V  +KA      +  K  CE+   
Sbjct: 451 MKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRR 510

Query: 353 LPHFNFHNNIIVLIVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGR 412
           L  F        L   + N+ +K ++ +  +A +K+ +  +  + SL  ++++      +
Sbjct: 511 LREF------AKLYDTIRNERNKFVN-LLHKAHQKVNEIKERHKMSLNELEILRNSAVSQ 563

Query: 413 NYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKS 456
             +++  MLK    + I+E  ++ D   I    K    KEK+++
Sbjct: 564 ERKLQNSMLKHANNVTIRE-SMQNDVRKI--VSKLQEMKEKKEA 604


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 80/468 (17%), Positives = 204/468 (43%), Gaps = 45/468 (9%)

Query: 41  KYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQL- 99
           +++K  R + +  K+   +  + LE  +     + ++++  E +E LPL   ++ ++QL 
Sbjct: 191 RHKKADRYIEELTKE---RDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLN 247

Query: 100 ---MKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIK 156
              +K   +R  FL   + ++       R+ E + ++ +KI    +   EK       ++
Sbjct: 248 VKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKI----RKQEEKMWRQEERLR 303

Query: 157 DKSGIIPQ------TREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKK 210
           ++ G + +       +EK + +  K+  +QE+E   ++E+ E   Q    EE + E+++K
Sbjct: 304 EQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEK 363

Query: 211 LQEKKMHIAALASAILSDPE---NNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFK 267
           ++E++  +      +    +      +K+++    + EQD  +     ++      ++++
Sbjct: 364 MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERM--REQEKMWE 421

Query: 268 DITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLKKS 327
            +    + + + E EK  KTR + +K++E E   + + +  +   E+ +++ +++  K+ 
Sbjct: 422 QVEKMREEKKMQEQEK--KTRDQEEKMQEEER--IREREKKMREEEETMREQEEKMQKQE 477

Query: 328 NVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDMSKLISEMCCEAVKK 387
             +  +  K   +  +    E L            I      + D  ++  +      KK
Sbjct: 478 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ-----EKK 532

Query: 388 LFKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKKF 447
           +++Q+K+ +             + + +E   +M      +  +E  ++K T++  + KK 
Sbjct: 533 MWRQEKMREQ------------EDQMWEQEEKMRDQEQKMWDQEERMEKKTQE--QEKKT 578

Query: 448 MTFKEKRKSLSRMQRKWKKAEEKLERELREAEASESTEKKLKLHTETL 495
              +EK +   RM+ + KK  E+ E    + E  +  E+K++   E +
Sbjct: 579 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 63/315 (20%), Positives = 141/315 (44%), Gaps = 31/315 (9%)

Query: 18  KTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIE 77
           +  K++ E K++ ++ K +   +K ++E+R +R              E  K+ R  +   
Sbjct: 422 QVEKMREEKKMQEQEKKTRDQEEKMQEEER-IR--------------EREKKMREEEETM 466

Query: 78  REEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKI 137
           RE+EE+ +    +M ++++ +  +   QR+      L   E +   + + E+I ++ EKI
Sbjct: 467 REQEEKMQKQEENMWEQEEKEWQQ---QRLPEQKEKLWEQEKM---QEQEEKIWEQEEKI 520

Query: 138 -PRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNK---DEEDQEEERELEEEIIED 193
             +      EK++     ++++   + +  EK      K    EE  E++ + +E+   D
Sbjct: 521 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580

Query: 194 PIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVT 253
             +++  EE + ER+KK++E++  +      +    E    K++E    + EQ+  +   
Sbjct: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE----KMQEQEEKMWEQEEKMQEQ 636

Query: 254 VRKL--VIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLEN 311
             K+      + E  + +    ++    E     +  +E +K++E EE +  Q K   + 
Sbjct: 637 EEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKT 696

Query: 312 LEQMVKDWKQRKLKK 326
            EQ  K W Q K+++
Sbjct: 697 QEQEKKTWDQEKMRE 711



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 71/337 (21%), Positives = 143/337 (42%), Gaps = 39/337 (11%)

Query: 5   RNKKQIPSFRKLIKTSKVKL---ENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKP 61
           R ++++    K I+  + K+   E +L+ ++ K +   +K  +++++LR+  K+      
Sbjct: 276 RQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKEL----- 330

Query: 62  IPLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDL--QLMKDLGQRVSFLTRDLSSSEP 119
              E  KE R  K +  +EE+ +E        E+ +  Q  K   Q      ++    E 
Sbjct: 331 --REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ 388

Query: 120 VHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEED 179
               + + ER+ ++ E++    +   E+E       K    +     EK + +  K   D
Sbjct: 389 EQKMRDQEERMWEQDERLREKEERMREQE-------KMWEQVEKMREEKKMQEQEKKTRD 441

Query: 180 QEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKEL 239
           QEE+ + EE I E   +    EE + E+++K+Q+++ ++         + E   ++L E 
Sbjct: 442 QEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE-----QEEKEWQQQRLPEQ 496

Query: 240 RSMLMEQDPDVAVTVRKLVIVSLMELFKDI-TPSYKIRPLTEAEKSTKTRKETQKLREFE 298
           +  L EQ+              + E  + I     KIR   E     K     +K+RE E
Sbjct: 497 KEKLWEQE-------------KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543

Query: 299 EGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAY 335
           + +  Q +  + + EQ + D ++R  KK+     K +
Sbjct: 544 DQMWEQEE-KMRDQEQKMWDQEERMEKKTQEQEKKTW 579



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 60/336 (17%), Positives = 154/336 (45%), Gaps = 19/336 (5%)

Query: 2   KARRNKKQIPSFRKLI-KTSKVKLENKLKNKQFK---QQSTLKKYRKEQRKLRQAVKDAV 57
           K R  KK     +K   +  K++ E +++ ++ K   ++ T+++  ++ +K  + + +  
Sbjct: 425 KMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQE 484

Query: 58  SKKPIPLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLM---KDLGQRVSFLTRDL 114
            K+      P++K      E+ +E+EE+    +    D  ++    K + ++     ++ 
Sbjct: 485 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544

Query: 115 SSSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSN 174
              E     + + +++ D+ E++ +  Q   +K       ++++  +  + REK + +  
Sbjct: 545 QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERM--REREKKMREEE 602

Query: 175 KDEEDQEEERELEEEIIEDPIQEL-TIEEHLIERKKKL--QEKKM---HIAALASAILSD 228
           +   +QEE+ + +EE +++  +++   EE + E+++K+  QE+KM            L +
Sbjct: 603 EMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE 662

Query: 229 PENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEA-EKSTKT 287
            +  + + ++++     Q+ +  +  ++ +     E  K      K+R      E+  K 
Sbjct: 663 QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKM 722

Query: 288 RKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRK 323
           R+E + +RE EE +  Q +   E  E+M   W+Q +
Sbjct: 723 REEEEMMREQEEKMQEQEEKMQEQEEEM---WEQEE 755



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 50/279 (17%), Positives = 120/279 (43%), Gaps = 32/279 (11%)

Query: 29  KNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEALP 88
           + K + Q+  ++K  +EQ K     ++ + ++    E  K+ R  + + RE+EE+ +   
Sbjct: 557 EQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQE 616

Query: 89  LDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKE 148
             M ++++               ++    E       + E++ ++ EK+    +   +KE
Sbjct: 617 EKMQEQEE-----------KMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKE 665

Query: 149 LIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERK 208
            +       +   + +  EK       +++ QE+E++  ++      +++  EE + ER+
Sbjct: 666 KLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQ------EKMREEESMRERE 719

Query: 209 KKLQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKD 268
           KK++E++         ++ + E   +K++E    + EQ+ ++     K+         + 
Sbjct: 720 KKMREEE--------EMMREQE---EKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ 768

Query: 269 ITPSYKIRPLTEAEKSTKTRK---ETQKLREFEEGLVSQ 304
             P  K   L E EK  +  K   + +K+R+ EE +  Q
Sbjct: 769 RLPEQK-EKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQ 806



 Score = 33.5 bits (75), Expect = 0.80
 Identities = 40/202 (19%), Positives = 96/202 (47%), Gaps = 15/202 (7%)

Query: 21  KVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVK--DAVSKKPIPLENPKEKRPGKRIER 78
           K++ E +++ ++ K +   +  R+++ K+++  +      +K    E   +++  K  E+
Sbjct: 584 KMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQ 643

Query: 79  EE---EEEEEALPLDMMDEDDLQLMK----DLGQRVSFLTRDLSSSEPVHAKKRKHERII 131
           EE   E+EE+      + E   +L +       +++      +   E +  K ++ E+  
Sbjct: 644 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703

Query: 132 DKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEII 191
              EK+ R  ++  E+E      ++++  ++ +  EK      K +E QEEE   +EE +
Sbjct: 704 WDQEKM-REEESMREREK----KMREEEEMMREQEEKMQEQEEKMQE-QEEEMWEQEEKM 757

Query: 192 EDPIQELTIEEHLIERKKKLQE 213
            +  +++  ++ L E+K+KL E
Sbjct: 758 WEQEEKMWEQQRLPEQKEKLWE 779


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 97/457 (21%), Positives = 186/457 (40%), Gaps = 66/457 (14%)

Query: 71   RPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERI 130
            +P  ++ R+EEE +         ED+LQ  K+  Q+      +L   E  H++  + + +
Sbjct: 842  KPLLQVTRQEEEMQAK-------EDELQKTKERQQKAE---NELKELEQKHSQLTEEKNL 891

Query: 131  IDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEI 190
            + +  +    L    E+  + L   K +   I    E  +      EE+++  ++L+ E 
Sbjct: 892  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL------EEEEDRGQQLQAER 945

Query: 191  IEDPIQELTIEEHLIER---KKKLQEKKM----HIAALASAIL-SDPENNIKKLKELRSM 242
             +   Q L +EE L E    ++KLQ +K+     I  L   IL  D +NN  KL + R +
Sbjct: 946  KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN--KLSKERKL 1003

Query: 243  LMEQDPDVAVTV-----RKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREF 297
            L E+  D+   +     +   +  L    + +    ++R     +K  K+R+E +KL+  
Sbjct: 1004 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR----LKKEEKSRQELEKLKRK 1059

Query: 298  EEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFN 357
             EG  S +   + +L+  + + K +  KK   +     +   E+A K             
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK------------- 1106

Query: 358  FHNNIIVLIVPLMNDMSKLISEMCCE--AVKKLFKQDKLGQASLGVIKVISGFVKGRNYE 415
              NN +  I  L   +S L  ++  E  A  K  KQ +     L  +K           E
Sbjct: 1107 --NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT----------E 1154

Query: 416  VRPEMLKTFLCLRIKEVEVKKDTE-DINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERE 474
            +   +  T      +E+  K++ E  + K       +     +  M++K  +A E+L  +
Sbjct: 1155 LEDTLDST---ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211

Query: 475  LREAEASESTEKKLKLHTETLNIVFVTYFRILKKAQR 511
            L + + +++   K K   E  N       R+L +A++
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 74/349 (21%), Positives = 146/349 (41%), Gaps = 66/349 (18%)

Query: 7    KKQIPSFRKLIKTSKVKLENKLKNKQF---KQQSTLKKYRKEQRKLRQAVKDAVSKKPIP 63
            +++  ++ KL KT K +L+ +L +       Q+  +    K+QRK  Q + +   +K I 
Sbjct: 1409 EEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE---EKNIS 1464

Query: 64   LENPKEKRPGKRIEREEEEEE-EALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHA 122
             +   E+    R E E  E+E +AL L    E+ L+  ++L +    L  ++   E + +
Sbjct: 1465 SKYADER---DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM---EDLVS 1518

Query: 123  KKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSN-------- 174
             K    + + + EK  R L+T  E+    L  ++D+       + +   +          
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578

Query: 175  ----KDEEDQEEERELEEEI-----------------------IEDPIQELTIE------ 201
                +DE+++E+ R+L+ ++                       +E  +++L ++      
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638

Query: 202  --EHLIERKKKLQ------EKKMHIA-ALASAILSDPENNIKKLKELRSMLMEQDPDVAV 252
              E  I++ +KLQ      ++++  A A    I +  + N KK K L + LM+   D+A 
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698

Query: 253  T--VRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEE 299
                RK   +   EL +++  S   R   + EK     +  Q   E EE
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 100/520 (19%), Positives = 205/520 (39%), Gaps = 64/520 (12%)

Query: 2    KARRNKKQIPSFRKLIKTS------KVKLENKLKNKQFKQQSTLKKYRKEQ--------R 47
            KA + K+ +    + +KT           + +L+ K+ ++ + LKK   E+        +
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195

Query: 48   KLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEA------LPLDMMDEDDLQLMK 101
            ++RQ    AV +    LE  K  +      ++  E+E A        L    ++     K
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255

Query: 102  DLGQRVSFLTRDLSSSEPVHAKKR-KHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSG 160
             L  +V  L    S  E   A+   K  ++ ++ E +   L  A  K +     +   S 
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315

Query: 161  IIPQTRE-------KPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQE 213
             +  T+E       + +  S K  + +EE   L++++ E+   +  +E H+     +L +
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375

Query: 214  KKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVS--LMELFKDITP 271
             K  +   AS + +  E   +  KE+ + L +Q  + A    KL      L +   D+  
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIEN-LTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434

Query: 272  SYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVS 331
                +    +    K RK  Q L E E+ + S+Y    +  E   ++      K++  +S
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEARE------KETKALS 1487

Query: 332  LKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDMSKLIS--EMCCEAVKKLF 389
            L           ++L E L A       N +      L  +M  L+S  +   + V +L 
Sbjct: 1488 L----------ARALEEALEAKEELERTNKM------LKAEMEDLVSSKDDVGKNVHELE 1531

Query: 390  KQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKKFMT 449
            K  +  +  +  +K     ++          L+  + ++  + + ++D +  ++      
Sbjct: 1532 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN---- 1587

Query: 450  FKEKRKSLSRMQRKWKKAEEKLERELREAEASESTEKKLK 489
             +EKR+ L   QR+  + E +LE E ++   + + +KKL+
Sbjct: 1588 -EEKRRQL---QRQLHEYETELEDERKQRALAAAAKKKLE 1623



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 56/250 (22%), Positives = 107/250 (42%), Gaps = 32/250 (12%)

Query: 21   KVKLENKLKNKQFKQQSTL-------KKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPG 73
            K K   KLKNK     S L       +K R+E  KL++ ++   S     + + + +   
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080

Query: 74   KRIEREEEEEEEALPLDMMDED------DLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKH 127
             +++  ++EEE    L  +D++       L+ +++L   +S L  DL S      K  K 
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140

Query: 128  ERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNK--DEEDQEEERE 185
            +R  D  E++      A + EL   L        +   RE+ VT   K  DEE +  E +
Sbjct: 1141 KR--DLGEEL-----EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193

Query: 186  LEE---------EIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIK-K 235
            ++E         E + + +++    +  +++ K+  EK+    A    +L   +  ++ K
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253

Query: 236  LKELRSMLME 245
             K+L + + E
Sbjct: 1254 KKKLEAQVQE 1263


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 97/457 (21%), Positives = 186/457 (40%), Gaps = 66/457 (14%)

Query: 71   RPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERI 130
            +P  ++ R+EEE +         ED+LQ  K+  Q+      +L   E  H++  + + +
Sbjct: 849  KPLLQVTRQEEEMQAK-------EDELQKTKERQQKAE---NELKELEQKHSQLTEEKNL 898

Query: 131  IDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEI 190
            + +  +    L    E+  + L   K +   I    E  +      EE+++  ++L+ E 
Sbjct: 899  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL------EEEEDRGQQLQAER 952

Query: 191  IEDPIQELTIEEHLIER---KKKLQEKKM----HIAALASAIL-SDPENNIKKLKELRSM 242
             +   Q L +EE L E    ++KLQ +K+     I  L   IL  D +NN  KL + R +
Sbjct: 953  KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN--KLSKERKL 1010

Query: 243  LMEQDPDVAVTV-----RKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREF 297
            L E+  D+   +     +   +  L    + +    ++R     +K  K+R+E +KL+  
Sbjct: 1011 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR----LKKEEKSRQELEKLKRK 1066

Query: 298  EEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFN 357
             EG  S +   + +L+  + + K +  KK   +     +   E+A K             
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK------------- 1113

Query: 358  FHNNIIVLIVPLMNDMSKLISEMCCE--AVKKLFKQDKLGQASLGVIKVISGFVKGRNYE 415
              NN +  I  L   +S L  ++  E  A  K  KQ +     L  +K           E
Sbjct: 1114 --NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT----------E 1161

Query: 416  VRPEMLKTFLCLRIKEVEVKKDTE-DINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERE 474
            +   +  T      +E+  K++ E  + K       +     +  M++K  +A E+L  +
Sbjct: 1162 LEDTLDST---ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218

Query: 475  LREAEASESTEKKLKLHTETLNIVFVTYFRILKKAQR 511
            L + + +++   K K   E  N       R+L +A++
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 74/349 (21%), Positives = 146/349 (41%), Gaps = 66/349 (18%)

Query: 7    KKQIPSFRKLIKTSKVKLENKLKNKQF---KQQSTLKKYRKEQRKLRQAVKDAVSKKPIP 63
            +++  ++ KL KT K +L+ +L +       Q+  +    K+QRK  Q + +   +K I 
Sbjct: 1416 EEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE---EKNIS 1471

Query: 64   LENPKEKRPGKRIEREEEEEE-EALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHA 122
             +   E+    R E E  E+E +AL L    E+ L+  ++L +    L  ++   E + +
Sbjct: 1472 SKYADER---DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM---EDLVS 1525

Query: 123  KKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSN-------- 174
             K    + + + EK  R L+T  E+    L  ++D+       + +   +          
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585

Query: 175  ----KDEEDQEEERELEEEI-----------------------IEDPIQELTIE------ 201
                +DE+++E+ R+L+ ++                       +E  +++L ++      
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645

Query: 202  --EHLIERKKKLQ------EKKMHIA-ALASAILSDPENNIKKLKELRSMLMEQDPDVAV 252
              E  I++ +KLQ      ++++  A A    I +  + N KK K L + LM+   D+A 
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705

Query: 253  T--VRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEE 299
                RK   +   EL +++  S   R   + EK     +  Q   E EE
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 100/520 (19%), Positives = 205/520 (39%), Gaps = 64/520 (12%)

Query: 2    KARRNKKQIPSFRKLIKTS------KVKLENKLKNKQFKQQSTLKKYRKEQ--------R 47
            KA + K+ +    + +KT           + +L+ K+ ++ + LKK   E+        +
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202

Query: 48   KLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEA------LPLDMMDEDDLQLMK 101
            ++RQ    AV +    LE  K  +      ++  E+E A        L    ++     K
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262

Query: 102  DLGQRVSFLTRDLSSSEPVHAKKR-KHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSG 160
             L  +V  L    S  E   A+   K  ++ ++ E +   L  A  K +     +   S 
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 161  IIPQTRE-------KPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQE 213
             +  T+E       + +  S K  + +EE   L++++ E+   +  +E H+     +L +
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382

Query: 214  KKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVS--LMELFKDITP 271
             K  +   AS + +  E   +  KE+ + L +Q  + A    KL      L +   D+  
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIEN-LTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441

Query: 272  SYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVS 331
                +    +    K RK  Q L E E+ + S+Y    +  E   ++      K++  +S
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEARE------KETKALS 1494

Query: 332  LKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDMSKLIS--EMCCEAVKKLF 389
            L           ++L E L A       N +      L  +M  L+S  +   + V +L 
Sbjct: 1495 L----------ARALEEALEAKEELERTNKM------LKAEMEDLVSSKDDVGKNVHELE 1538

Query: 390  KQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKKFMT 449
            K  +  +  +  +K     ++          L+  + ++  + + ++D +  ++      
Sbjct: 1539 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN---- 1594

Query: 450  FKEKRKSLSRMQRKWKKAEEKLERELREAEASESTEKKLK 489
             +EKR+ L   QR+  + E +LE E ++   + + +KKL+
Sbjct: 1595 -EEKRRQL---QRQLHEYETELEDERKQRALAAAAKKKLE 1630



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 56/250 (22%), Positives = 107/250 (42%), Gaps = 32/250 (12%)

Query: 21   KVKLENKLKNKQFKQQSTL-------KKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPG 73
            K K   KLKNK     S L       +K R+E  KL++ ++   S     + + + +   
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087

Query: 74   KRIEREEEEEEEALPLDMMDED------DLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKH 127
             +++  ++EEE    L  +D++       L+ +++L   +S L  DL S      K  K 
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147

Query: 128  ERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNK--DEEDQEEERE 185
            +R  D  E++      A + EL   L        +   RE+ VT   K  DEE +  E +
Sbjct: 1148 KR--DLGEEL-----EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200

Query: 186  LEE---------EIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIK-K 235
            ++E         E + + +++    +  +++ K+  EK+    A    +L   +  ++ K
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260

Query: 236  LKELRSMLME 245
             K+L + + E
Sbjct: 1261 KKKLEAQVQE 1270


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 97/457 (21%), Positives = 186/457 (40%), Gaps = 66/457 (14%)

Query: 71   RPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERI 130
            +P  ++ R+EEE +         ED+LQ  K+  Q+      +L   E  H++  + + +
Sbjct: 849  KPLLQVTRQEEEMQAK-------EDELQKTKERQQKAE---NELKELEQKHSQLTEEKNL 898

Query: 131  IDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEI 190
            + +  +    L    E+  + L   K +   I    E  +      EE+++  ++L+ E 
Sbjct: 899  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL------EEEEDRGQQLQAER 952

Query: 191  IEDPIQELTIEEHLIER---KKKLQEKKM----HIAALASAIL-SDPENNIKKLKELRSM 242
             +   Q L +EE L E    ++KLQ +K+     I  L   IL  D +NN  KL + R +
Sbjct: 953  KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN--KLSKERKL 1010

Query: 243  LMEQDPDVAVTV-----RKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREF 297
            L E+  D+   +     +   +  L    + +    ++R     +K  K+R+E +KL+  
Sbjct: 1011 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR----LKKEEKSRQELEKLKRK 1066

Query: 298  EEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFN 357
             EG  S +   + +L+  + + K +  KK   +     +   E+A K             
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK------------- 1113

Query: 358  FHNNIIVLIVPLMNDMSKLISEMCCE--AVKKLFKQDKLGQASLGVIKVISGFVKGRNYE 415
              NN +  I  L   +S L  ++  E  A  K  KQ +     L  +K           E
Sbjct: 1114 --NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT----------E 1161

Query: 416  VRPEMLKTFLCLRIKEVEVKKDTE-DINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERE 474
            +   +  T      +E+  K++ E  + K       +     +  M++K  +A E+L  +
Sbjct: 1162 LEDTLDST---ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218

Query: 475  LREAEASESTEKKLKLHTETLNIVFVTYFRILKKAQR 511
            L + + +++   K K   E  N       R+L +A++
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 74/349 (21%), Positives = 146/349 (41%), Gaps = 66/349 (18%)

Query: 7    KKQIPSFRKLIKTSKVKLENKLKNKQF---KQQSTLKKYRKEQRKLRQAVKDAVSKKPIP 63
            +++  ++ KL KT K +L+ +L +       Q+  +    K+QRK  Q + +   +K I 
Sbjct: 1416 EEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE---EKNIS 1471

Query: 64   LENPKEKRPGKRIEREEEEEE-EALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHA 122
             +   E+    R E E  E+E +AL L    E+ L+  ++L +    L  ++   E + +
Sbjct: 1472 SKYADER---DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM---EDLVS 1525

Query: 123  KKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSN-------- 174
             K    + + + EK  R L+T  E+    L  ++D+       + +   +          
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585

Query: 175  ----KDEEDQEEERELEEEI-----------------------IEDPIQELTIE------ 201
                +DE+++E+ R+L+ ++                       +E  +++L ++      
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645

Query: 202  --EHLIERKKKLQ------EKKMHIA-ALASAILSDPENNIKKLKELRSMLMEQDPDVAV 252
              E  I++ +KLQ      ++++  A A    I +  + N KK K L + LM+   D+A 
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705

Query: 253  T--VRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEE 299
                RK   +   EL +++  S   R   + EK     +  Q   E EE
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 100/520 (19%), Positives = 205/520 (39%), Gaps = 64/520 (12%)

Query: 2    KARRNKKQIPSFRKLIKTS------KVKLENKLKNKQFKQQSTLKKYRKEQ--------R 47
            KA + K+ +    + +KT           + +L+ K+ ++ + LKK   E+        +
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202

Query: 48   KLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEA------LPLDMMDEDDLQLMK 101
            ++RQ    AV +    LE  K  +      ++  E+E A        L    ++     K
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262

Query: 102  DLGQRVSFLTRDLSSSEPVHAKKR-KHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSG 160
             L  +V  L    S  E   A+   K  ++ ++ E +   L  A  K +     +   S 
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 161  IIPQTRE-------KPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQE 213
             +  T+E       + +  S K  + +EE   L++++ E+   +  +E H+     +L +
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382

Query: 214  KKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVS--LMELFKDITP 271
             K  +   AS + +  E   +  KE+ + L +Q  + A    KL      L +   D+  
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIEN-LTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441

Query: 272  SYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVS 331
                +    +    K RK  Q L E E+ + S+Y    +  E   ++      K++  +S
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEARE------KETKALS 1494

Query: 332  LKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDMSKLIS--EMCCEAVKKLF 389
            L           ++L E L A       N +      L  +M  L+S  +   + V +L 
Sbjct: 1495 L----------ARALEEALEAKEELERTNKM------LKAEMEDLVSSKDDVGKNVHELE 1538

Query: 390  KQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKKFMT 449
            K  +  +  +  +K     ++          L+  + ++  + + ++D +  ++      
Sbjct: 1539 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN---- 1594

Query: 450  FKEKRKSLSRMQRKWKKAEEKLERELREAEASESTEKKLK 489
             +EKR+ L   QR+  + E +LE E ++   + + +KKL+
Sbjct: 1595 -EEKRRQL---QRQLHEYETELEDERKQRALAAAAKKKLE 1630



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 56/250 (22%), Positives = 107/250 (42%), Gaps = 32/250 (12%)

Query: 21   KVKLENKLKNKQFKQQSTL-------KKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPG 73
            K K   KLKNK     S L       +K R+E  KL++ ++   S     + + + +   
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087

Query: 74   KRIEREEEEEEEALPLDMMDED------DLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKH 127
             +++  ++EEE    L  +D++       L+ +++L   +S L  DL S      K  K 
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147

Query: 128  ERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNK--DEEDQEEERE 185
            +R  D  E++      A + EL   L        +   RE+ VT   K  DEE +  E +
Sbjct: 1148 KR--DLGEEL-----EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200

Query: 186  LEE---------EIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIK-K 235
            ++E         E + + +++    +  +++ K+  EK+    A    +L   +  ++ K
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260

Query: 236  LKELRSMLME 245
             K+L + + E
Sbjct: 1261 KKKLEAQVQE 1270


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 97/457 (21%), Positives = 186/457 (40%), Gaps = 66/457 (14%)

Query: 71   RPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERI 130
            +P  ++ R+EEE +         ED+LQ  K+  Q+      +L   E  H++  + + +
Sbjct: 842  KPLLQVTRQEEEMQAK-------EDELQKTKERQQKAE---NELKELEQKHSQLTEEKNL 891

Query: 131  IDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEI 190
            + +  +    L    E+  + L   K +   I    E  +      EE+++  ++L+ E 
Sbjct: 892  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL------EEEEDRGQQLQAER 945

Query: 191  IEDPIQELTIEEHLIER---KKKLQEKKM----HIAALASAIL-SDPENNIKKLKELRSM 242
             +   Q L +EE L E    ++KLQ +K+     I  L   IL  D +NN  KL + R +
Sbjct: 946  KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN--KLSKERKL 1003

Query: 243  LMEQDPDVAVTV-----RKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREF 297
            L E+  D+   +     +   +  L    + +    ++R     +K  K+R+E +KL+  
Sbjct: 1004 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR----LKKEEKSRQELEKLKRK 1059

Query: 298  EEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFN 357
             EG  S +   + +L+  + + K +  KK   +     +   E+A K             
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK------------- 1106

Query: 358  FHNNIIVLIVPLMNDMSKLISEMCCE--AVKKLFKQDKLGQASLGVIKVISGFVKGRNYE 415
              NN +  I  L   +S L  ++  E  A  K  KQ +     L  +K           E
Sbjct: 1107 --NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT----------E 1154

Query: 416  VRPEMLKTFLCLRIKEVEVKKDTE-DINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERE 474
            +   +  T      +E+  K++ E  + K       +     +  M++K  +A E+L  +
Sbjct: 1155 LEDTLDST---ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211

Query: 475  LREAEASESTEKKLKLHTETLNIVFVTYFRILKKAQR 511
            L + + +++   K K   E  N       R+L +A++
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 74/349 (21%), Positives = 146/349 (41%), Gaps = 66/349 (18%)

Query: 7    KKQIPSFRKLIKTSKVKLENKLKNKQF---KQQSTLKKYRKEQRKLRQAVKDAVSKKPIP 63
            +++  ++ KL KT K +L+ +L +       Q+  +    K+QRK  Q + +   +K I 
Sbjct: 1409 EEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE---EKNIS 1464

Query: 64   LENPKEKRPGKRIEREEEEEE-EALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHA 122
             +   E+    R E E  E+E +AL L    E+ L+  ++L +    L  ++   E + +
Sbjct: 1465 SKYADER---DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM---EDLVS 1518

Query: 123  KKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSN-------- 174
             K    + + + EK  R L+T  E+    L  ++D+       + +   +          
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578

Query: 175  ----KDEEDQEEERELEEEI-----------------------IEDPIQELTIE------ 201
                +DE+++E+ R+L+ ++                       +E  +++L ++      
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638

Query: 202  --EHLIERKKKLQ------EKKMHIA-ALASAILSDPENNIKKLKELRSMLMEQDPDVAV 252
              E  I++ +KLQ      ++++  A A    I +  + N KK K L + LM+   D+A 
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698

Query: 253  T--VRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEE 299
                RK   +   EL +++  S   R   + EK     +  Q   E EE
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 100/520 (19%), Positives = 205/520 (39%), Gaps = 64/520 (12%)

Query: 2    KARRNKKQIPSFRKLIKTS------KVKLENKLKNKQFKQQSTLKKYRKEQ--------R 47
            KA + K+ +    + +KT           + +L+ K+ ++ + LKK   E+        +
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195

Query: 48   KLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEA------LPLDMMDEDDLQLMK 101
            ++RQ    AV +    LE  K  +      ++  E+E A        L    ++     K
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255

Query: 102  DLGQRVSFLTRDLSSSEPVHAKKR-KHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSG 160
             L  +V  L    S  E   A+   K  ++ ++ E +   L  A  K +     +   S 
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315

Query: 161  IIPQTRE-------KPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQE 213
             +  T+E       + +  S K  + +EE   L++++ E+   +  +E H+     +L +
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375

Query: 214  KKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVS--LMELFKDITP 271
             K  +   AS + +  E   +  KE+ + L +Q  + A    KL      L +   D+  
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIEN-LTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434

Query: 272  SYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVS 331
                +    +    K RK  Q L E E+ + S+Y    +  E   ++      K++  +S
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEARE------KETKALS 1487

Query: 332  LKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDMSKLIS--EMCCEAVKKLF 389
            L           ++L E L A       N +      L  +M  L+S  +   + V +L 
Sbjct: 1488 L----------ARALEEALEAKEELERTNKM------LKAEMEDLVSSKDDVGKNVHELE 1531

Query: 390  KQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKKFMT 449
            K  +  +  +  +K     ++          L+  + ++  + + ++D +  ++      
Sbjct: 1532 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN---- 1587

Query: 450  FKEKRKSLSRMQRKWKKAEEKLERELREAEASESTEKKLK 489
             +EKR+ L   QR+  + E +LE E ++   + + +KKL+
Sbjct: 1588 -EEKRRQL---QRQLHEYETELEDERKQRALAAAAKKKLE 1623



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 56/250 (22%), Positives = 107/250 (42%), Gaps = 32/250 (12%)

Query: 21   KVKLENKLKNKQFKQQSTL-------KKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPG 73
            K K   KLKNK     S L       +K R+E  KL++ ++   S     + + + +   
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080

Query: 74   KRIEREEEEEEEALPLDMMDED------DLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKH 127
             +++  ++EEE    L  +D++       L+ +++L   +S L  DL S      K  K 
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140

Query: 128  ERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNK--DEEDQEEERE 185
            +R  D  E++      A + EL   L        +   RE+ VT   K  DEE +  E +
Sbjct: 1141 KR--DLGEEL-----EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193

Query: 186  LEE---------EIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIK-K 235
            ++E         E + + +++    +  +++ K+  EK+    A    +L   +  ++ K
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253

Query: 236  LKELRSMLME 245
             K+L + + E
Sbjct: 1254 KKKLEAQVQE 1263


>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
          Length = 1094

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 70/333 (21%), Positives = 146/333 (43%), Gaps = 43/333 (12%)

Query: 21  KVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREE 80
           K + E + ++ + K Q ++++++ + +KL +A++              ++  GK  +  +
Sbjct: 472 KEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQ--------SETVDELTGKNNQILK 523

Query: 81  EEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRT 140
           E++E    L    +    L K+L      LT+     E +H+K+ K   I  K  +    
Sbjct: 524 EKDELKTQLYAALQQIENLRKELND---VLTKRALQEEELHSKEEKLRDI--KSHQADLE 578

Query: 141 LQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTI 200
           L+     + IH L  + K              S    + + E+  LEEEI E    +   
Sbjct: 579 LEVKNSLDTIHRLESELKK------------QSKIQSQMKVEKAHLEEEIAELKKSQAQD 626

Query: 201 EEHLIERKKKLQEKKMHIAALASAILSDPENN---IKKLKELRSMLMEQDPDVAVTVRKL 257
           +  L+E ++ +++     A LA+ +  +       +K L +L +    +D + A      
Sbjct: 627 KAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETA------ 680

Query: 258 VIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQMVK 317
            I++ ++L +D+    +++ LT + +S KT+ E Q ++E    L+  +K      E  ++
Sbjct: 681 TIITQLKLERDV-HQRELKDLTSSLQSVKTKHE-QNIQE----LMKHFKKEKSEAENHIR 734

Query: 318 DWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELL 350
             K   L++ N+   K ++G  E  +KS C+ L
Sbjct: 735 TLKAESLEEKNMA--KIHRGQLE-KLKSQCDRL 764


>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
            [Homo sapiens]
          Length = 1388

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 104/534 (19%), Positives = 231/534 (43%), Gaps = 71/534 (13%)

Query: 6    NKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLE 65
            N + +     L++T+K+KLE +  N     QS L+  R+++    + + D +  +   LE
Sbjct: 598  NNRDLQDKNCLLETAKLKLEKEFIN----LQSALESERRDRTHGSEIIND-LQGRICGLE 652

Query: 66   NPKEKRPGK----RIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVH 121
              ++ + GK    ++E E+ + +E       ++ ++++  D+  ++  + + L   E  H
Sbjct: 653  --EDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEI--DMTYQLKVIQQSLEQEEAEH 708

Query: 122  AKKRKHERIIDK---YEKIPRTLQTA---PEKELIHLLPIKDKSGIIPQTREKPVTDSNK 175
              K    R+ DK   YE I      A    EK+L+    +K K   +    EK  +  + 
Sbjct: 709  --KATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDC 766

Query: 176  D-EEDQEEEREL--EEEIIEDPIQELTI-------EEHLIERKKKLQEKKMHIAALASAI 225
            D ++ Q++  EL  +++++ + ++ LT+       +  L +   K+Q ++++   ++   
Sbjct: 767  DLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQ 826

Query: 226  LSDPENNIKKLK----ELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPL-TE 280
            L    N++ ++K    +  + L ++  D    +++L      E +       ++R L  E
Sbjct: 827  LKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEE 886

Query: 281  AEKSTKTRKE----TQKLREFEEGLVSQYKFYL-----ENLEQMVKDWKQRKLKKSNVVS 331
             E+ TK  KE     Q+L++  + L +Q +  L     E L + + + +   L+K  ++ 
Sbjct: 887  CEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMK 946

Query: 332  LKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVL-IVPLMNDMSKLISEMCCEAVKKLFK 390
                K +     + L E    +      N  +   +  L N+  +L +++  + V++   
Sbjct: 947  ELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKL--KDVQEQLS 1004

Query: 391  QDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEVKK-------DTEDINK 443
            + K  + S   IK      +     +    LKT    ++ E+  +K       DT+   K
Sbjct: 1005 RLKDEEISAAAIK-----AQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRK 1059

Query: 444  PKK----FMTFKEKRKSLSRMQRKWKKAEEKLERELREAEASESTEKKLKLHTE 493
             K+     M  K +R+ L++   K++K       EL E +A  + E ++++  +
Sbjct: 1060 EKENRKLHMELKSEREKLTQQMIKYQK-------ELNEMQAQIAEESQIRIELQ 1106



 Score = 37.7 bits (86), Expect = 0.042
 Identities = 99/521 (19%), Positives = 206/521 (39%), Gaps = 65/521 (12%)

Query: 7    KKQIPSFRKLIKTSKVKLE--NKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPL 64
            K Q+   +K  + S++  E  N+L+ +  +  + L+       +LR+   ++ SK+   L
Sbjct: 537  KDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAES-SKQIQQL 595

Query: 65   ENPKEKRPGK---------RIEREEEEEEEALPLDMMDEDD-LQLMKDLGQRVSFLTRDL 114
            E+       K         ++E+E    + AL  +  D     +++ DL  R+  L  DL
Sbjct: 596  ESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDL 655

Query: 115  SSSEPVHAK----KRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPV 170
             + + + AK    KR+ +      EK    ++     +L  +    ++     +  +  +
Sbjct: 656  KNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARL 715

Query: 171  TDSNK-----DEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAI 225
             D NK     +E   E  +E+E++++E+   +  +E  L+E +K+         +L    
Sbjct: 716  ADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKR--------CSLLDCD 767

Query: 226  LSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKST 285
            L   +  I +L + + +L E        VR L +                    + E+ T
Sbjct: 768  LKQSQQKINELLKQKDVLNED-------VRNLTL--------------------KIEQET 800

Query: 286  KTRKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRK--LKKSNVVSLKAYKGLAEVAV 343
            + R  TQ   + +   V+  K   + L+Q      + K  L+K N   L+  +  A+  +
Sbjct: 801  QKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQN-AELRKERQDADGQM 859

Query: 344  KSLCELLVALPHFN-FHNNIIVLIVPLMNDMSKLISEMCCEAVKKLFKQDKL-GQASLGV 401
            K L + L A  +F+  +   +  +     + +KL  E+  +  +   ++D L  Q  + +
Sbjct: 860  KELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITL 919

Query: 402  IKVISGFVKGRNYEVR---PEMLKTFLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKSLS 458
             K  S  +     E +    E  K    L IKE+  +   E   K     + +E  ++L+
Sbjct: 920  TKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLT 979

Query: 459  RMQRKWKKAEEKLERELREAEASESTEKKLKLHTETLNIVF 499
                     +E+L  +L++ +   S  K  ++    +   F
Sbjct: 980  SDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQF 1020


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 54/248 (21%), Positives = 111/248 (44%), Gaps = 34/248 (13%)

Query: 28   LKNKQFKQQSTLKKYRKEQRKLRQAV-------KDAVSKKPIPLENPKEKRPGKRIEREE 80
            LK  + K + TLKKY  E R+L +A+       K+AVS +   LEN  E   G   +  +
Sbjct: 855  LKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARR-ALENELEAAQGNLSQTTQ 913

Query: 81   EEEE--EALPLDMMDEDDLQLMKD--------LGQRVSFLTRDLSS------------SE 118
            E+++  E L  +   ++ L+ +K+        LG+ +  L ++++               
Sbjct: 914  EQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQN 973

Query: 119  PVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEE 178
             +   K K+ R + + ++  +      EK  +  + ++D+  ++    E+ + D  + ++
Sbjct: 974  QLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLM----EEELRDYQRAQD 1029

Query: 179  DQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKE 238
            +   +R+L E+ ++D   EL  + HL + + +L ++     +     L +  NN   L E
Sbjct: 1030 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSE 1089

Query: 239  LRSMLMEQ 246
              S   EQ
Sbjct: 1090 RISRSREQ 1097



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 64/336 (19%), Positives = 148/336 (44%), Gaps = 41/336 (12%)

Query: 23   KLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEE 82
            +L+N+++N+++    T++K +KE   + +A + +  +    L+  KEK   +  E + + 
Sbjct: 934  RLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQL 993

Query: 83   EEEALPLD------MMDEDDLQLMKD------------------LGQRVSFLTRDLSSSE 118
            +E+ L  +      M  +D+++LM++                  L Q +  L  +L +  
Sbjct: 994  KEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKS 1053

Query: 119  PVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEE 178
             +   K    R++ + E     L+   E+E  +   + ++   I ++RE+     N+  +
Sbjct: 1054 HL---KDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSER---ISRSREQMEQLRNELLQ 1107

Query: 179  DQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKE 238
            ++   ++LE + I    Q   ++  +I  +   +  K  +     A +++ E+ ++  + 
Sbjct: 1108 ERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEER 1167

Query: 239  LRSMLMEQDPDVAVTVRKLVI------VSLMELFKDITPSYKI--RPLTEAEKSTKTRKE 290
             R+ L   +  +   V++LV+      +SL +    ++   K   R + EAE+     + 
Sbjct: 1168 DRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLES 1227

Query: 291  TQK--LREFEEGLVSQYKFYLENLEQMVKDWKQRKL 324
            ++K   RE EE +    +     L  M KD + +KL
Sbjct: 1228 SKKKLQRELEEQM-DMNEHLQGQLNSMKKDLRLKKL 1262



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 71/339 (20%), Positives = 147/339 (43%), Gaps = 45/339 (13%)

Query: 20   SKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKE---------- 69
            +K  L++ L  K+ +Q+  L+K  +E   L+ A+K+ VS     ++  KE          
Sbjct: 735  AKQDLQDLLIAKE-EQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALR 793

Query: 70   ---KRPGKRIE--------REEEEEEEALPLDMMDEDDLQLM---KDLGQRVSFLTRDLS 115
               +   K +E         E+++    + + ++ E++ +L    ++L +RV+ L R + 
Sbjct: 794  ESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQI- 852

Query: 116  SSEPVHAKKRKHERIIDKYEKIPRTLQTA------PEKELIHLL-----PIKDKSGIIPQ 164
              E +   + K +  + KYE   R L+ A       EKE +         ++   G + Q
Sbjct: 853  --EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQ 910

Query: 165  T--REKPVTDSNKDEEDQEEERELEEEIIEDPIQEL--TIEEHLIERKKKLQEKKMHIAA 220
            T   +K +++  K+E +Q+E+    +  +E+    L  TIE+   E    ++  +     
Sbjct: 911  TTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLE 970

Query: 221  LASAILSDPENNIKKLKELRSMLMEQDPDVAVT-VRKLVIVSLMELFKDITPSYKIRPLT 279
            L + +    E N ++L E++  L E+  +   + +  + +   M L ++    Y+ R   
Sbjct: 971  LQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ-RAQD 1029

Query: 280  EAEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQMVKD 318
            EA    +  ++T K  E+E    S  K     L + ++D
Sbjct: 1030 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMED 1068


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 101/506 (19%), Positives = 210/506 (41%), Gaps = 61/506 (12%)

Query: 23   KLENKLKNKQFK----------QQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRP 72
            +LEN +KN Q K          + + LK+   +   L +   D ++K    L+N  E+  
Sbjct: 556  ELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINK----LKNSHEEMD 611

Query: 73   GKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIID 132
                ++ E EE   L L    E  +Q   +L Q+V+ LT  L   E +  K +  +++  
Sbjct: 612  NFH-KKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLE--ETLKEKDQNDQKL-- 666

Query: 133  KYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNK-DEEDQEEERELEEEII 191
                         EK ++ +  + +   ++    +    ++NK   E ++  R+LE  + 
Sbjct: 667  -------------EKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLS 713

Query: 192  EDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVA 251
            +   +++ ++EH+ + +KKLQ        L   + ++    +    +L   L E   +V+
Sbjct: 714  QK--EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVS 771

Query: 252  VTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEG---LVSQYKFY 308
                +  +V++++   +      +  + E EK     +  +K+ E E+    L  +    
Sbjct: 772  EDSEEKDVVNVLQAVGE-----SLAKINE-EKCNLAFQRDEKVLELEKEIKCLQEESVVQ 825

Query: 309  LENLEQMVKDWKQRK-LKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHN-NIIVLI 366
             E L+ +++D++Q K L +  +  +++ K   E     L E+  A       N N+++ +
Sbjct: 826  CEELKSLLRDYEQEKVLLRKELEEIQSEK---EALQSDLLEMKNANEKTRLENQNLLIQV 882

Query: 367  VPLMNDMSKL----ISEMCC----EAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRP 418
              +    SK       E C     E +K L +Q +L      +I +     K  + +  P
Sbjct: 883  EEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDP 942

Query: 419  EMLKTFLCLRIK--EVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERELR 476
                  L  +I+  E E K+  E INK K  +   + +K L   +++ +  +E+LE    
Sbjct: 943  LSSVKELEEKIENLEKECKEKEEKINKIK--LVAVKAKKELDSSRKETQTVKEELESLRS 1000

Query: 477  EAEASESTEKKLKLHTETLNIVFVTY 502
            E +   ++ + L    E+   + + Y
Sbjct: 1001 EKDQLSASMRDLIQGAESYKNLLLEY 1026



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 113/578 (19%), Positives = 230/578 (39%), Gaps = 80/578 (13%)

Query: 5   RNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPL 64
           R+K        +IK    +L+  L  K   +Q  L   +KE  K++Q V+D+V+K     
Sbjct: 59  RSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLS-LKKENIKMKQEVEDSVTKMGDAH 117

Query: 65  ENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKK 124
           +  ++       E E  + E         ED   L K L + ++     L  SE +  + 
Sbjct: 118 KELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMN---TQLELSEQLKFQN 174

Query: 125 RKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEER 184
              + +    E+I + ++   E+++++L    D +     T EK  T +      +   +
Sbjct: 175 NSEDNVKKLQEEIEK-IRPGFEEQILYLQKQLDAT-----TDEKKETVTQLQNIIEANSQ 228

Query: 185 ELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLM 244
             ++ I        +++E L++ K   QE+   +     A   + E  I KL EL+  L+
Sbjct: 229 HYQKNIN-------SLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLV 281

Query: 245 EQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQ 304
           +Q       ++K     L  L K           + A +  +      +   F E +V++
Sbjct: 282 KQCEASEKNIQKKYECELENLRK---------ATSNANQDNQICSILLQENTFVEQVVNE 332

Query: 305 YKFYLENLEQMVKDWK-QRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNII 363
               +++LE  +K+ + Q  + K  V  +   K   E+  + + +         FH    
Sbjct: 333 ---KVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEF-------FHER-- 380

Query: 364 VLIVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVR------ 417
                   D+   I+E+     ++    +KL     G+ K     V+  N EV+      
Sbjct: 381 -------EDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQH 433

Query: 418 ----PEMLKTFLCLRIKE--------VEVKKDTEDINKPKK--FMTFKEKRKSLSRMQRK 463
                E+ +TFL    KE          +K+  E++ + K+   + ++  R+ +  +Q +
Sbjct: 434 QKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTE 493

Query: 464 WKKAEEKLERE---LREAEASESTEKKLKLHT---------ETLNIVFVTYFRILKKAQR 511
             ++  K+ +E   +++ +AS+  E + KL T         ET+N +     ++L + + 
Sbjct: 494 LGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQEL 553

Query: 512 SPLLPAVLEGLAK--FAHLINVEFFDDLLVVLHTLIES 547
            P L   ++ L +    +L+++   D +L  L   I S
Sbjct: 554 VPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINS 591



 Score = 37.0 bits (84), Expect = 0.072
 Identities = 75/433 (17%), Positives = 181/433 (41%), Gaps = 50/433 (11%)

Query: 74   KRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERI--- 130
            +++++E++ +E A  ++ ++E  +QL K+  Q    L + +   E V    ++   +   
Sbjct: 1106 EKLQKEQKIKEHATTVNELEELQVQLQKEKKQ----LQKTMQELELVKKDAQQTTLMNME 1161

Query: 131  IDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEI 190
            I  YE++ + L             + +K+  I    ++      K E  QEE   L+  +
Sbjct: 1162 IADYERLMKELNQK----------LTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSV 1211

Query: 191  IEDPIQELTIEEHLIERKKKLQEKKM----HIAALASAILSDPENNIKKLKELRSMLMEQ 246
             +   +   I++ L++ KK+L + K     H+  L +++  + E + ++++  +  L E 
Sbjct: 1212 QQYEEKNTKIKQLLVKTKKELADSKQAETDHL-ILQASLKGELEASQQQVEVYKIQLAE- 1269

Query: 247  DPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYK 306
                 +T  K     + E  K     ++       ++ T  ++E +  +  +  + S+++
Sbjct: 1270 -----ITSEK---HKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFE 1321

Query: 307  FYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLI 366
             Y   +  ++K  K + + ++     K  +   E+ +  L      +   +  NN+ + +
Sbjct: 1322 SYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL-----KIKLQDSQNNLQINV 1376

Query: 367  VPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLC 426
              L    S+   +   E   K+ ++    +A L   K+ S  ++  N  ++ E  +T   
Sbjct: 1377 SELQTLQSE--HDTLLERHNKMLQETVSKEAELRE-KLCS--IQSENMMMKSEHTQTVSQ 1431

Query: 427  LRIKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKL-----ERELREAEAS 481
            L  +   ++    D  +  +    +E RK++  +Q++  K E +L     E   R   +S
Sbjct: 1432 LTSQNEVLRNSFRDQVRHLQ----EEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSS 1487

Query: 482  ESTEKKLKLHTET 494
            + + K L+    T
Sbjct: 1488 QQSLKNLRERRNT 1500



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 68/319 (21%), Positives = 123/319 (38%), Gaps = 80/319 (25%)

Query: 15   KLIKTSKVKLE----NKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEK 70
            KL K  K+K      N+L+  Q + Q   K+ +K  ++L    KDA              
Sbjct: 1107 KLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDA-------------- 1152

Query: 71   RPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSE-PVHAKKRKHER 129
                         ++   ++M   D  +LMK+L Q+++     +   E  +  +K+K E 
Sbjct: 1153 -------------QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQET 1199

Query: 130  IIDKYEKIPRTLQTAPEKEL-IHLLPIKDKSGIIPQTREKPVTDSNKDEED--------- 179
            + ++   +  ++Q   EK   I  L +K K         K + DS + E D         
Sbjct: 1200 LQEEITSLQSSVQQYEEKNTKIKQLLVKTK---------KELADSKQAETDHLILQASLK 1250

Query: 180  -QEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKE 238
             + E  + + E+ +  + E+T E+H      K+ E     A      LS  +  +  L  
Sbjct: 1251 GELEASQQQVEVYKIQLAEITSEKH------KIHEHLKTSAEQHQRTLSAYQQRVTAL-- 1302

Query: 239  LRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIR---PLTEAEKSTKTRKETQ--- 292
                   Q+   A    +  + S  E       SYK+R    L + +  + ++ ET+   
Sbjct: 1303 -------QEECRAAKAEQATVTSEFE-------SYKVRVHNVLKQQKNKSMSQAETEGAK 1348

Query: 293  KLREFEEGLVSQYKFYLEN 311
            + RE  E L+ Q K  L++
Sbjct: 1349 QEREHLEMLIDQLKIKLQD 1367


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 123/577 (21%), Positives = 240/577 (41%), Gaps = 96/577 (16%)

Query: 2    KARRNK--KQIPSFRKLIKTSKVKLEN---------KLKNKQFKQQSTLKKYRKEQRKLR 50
            KA RNK  KQ     + ++  K +LE+         +L+ K+ ++ + LKK  +E+ K  
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH 1190

Query: 51   QA-VKDAVSKKPIPLENPKEK-RPGKRIEREEEEEEEALPLDMMD-EDDLQLMKDLGQRV 107
            +A ++D   +    LE   E+    KR +   E+ ++ L  D  +   ++++++ +    
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250

Query: 108  SFLTRDLSSS-EPVHAKKRKHERI-IDKYEKIPR---------TLQTAPEKELIHLLP-- 154
                + L +  + +HAK  + +R+ ++  EK  +         TL    EK+ I      
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDA 1310

Query: 155  ------IKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIED-------PIQELTIE 201
                  ++D   ++ +   + +  S++  + +EE+  L+E+  E+         Q L ++
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQ 1370

Query: 202  EHLIERKKKLQEKKMHIAALASA---ILSDPENNIKKLKE----------LRSMLMEQDP 248
              L + KKK+ +    I +L  A   +L D E   ++L+E           ++ L ++  
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430

Query: 249  DVAVTV------------RKLVIVSLMELFKDITPSY-KIRPLTEAEKSTKTRKETQKLR 295
            D+ V +            ++     L+   K I+  Y + R   EAE   K  K     R
Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLAR 1490

Query: 296  EFEEGLVSQYKFYLENLEQMVKDWKQRKLKK----SNVVSLKAYKGLAEVAVKSLCELLV 351
              EE L ++ +F  +N +Q+  D +     K     NV  L+  K   E  V+ +   L 
Sbjct: 1491 ALEEALEAKEEFERQN-KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE 1549

Query: 352  ALPHFNFHNNIIVLIVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIK--VISGFV 409
             L                  + +KL  E+  +A+K  F++D   +      K  ++   V
Sbjct: 1550 ELED-----------ELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQV 1598

Query: 410  KGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEE 469
            +    E+  E  +  L +  K+ +++ D +D+    +     + R  + +  RK +   +
Sbjct: 1599 RELEAELEDERKQRALAVASKK-KMEIDLKDLE--AQIEAANKARDEVIKQLRKLQAQMK 1655

Query: 470  KLERELREAEA--------SESTEKKLK-LHTETLNI 497
              +REL EA A        S+ +EKKLK L  E L +
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQL 1692



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 110/500 (22%), Positives = 193/500 (38%), Gaps = 76/500 (15%)

Query: 14   RKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKD--AVSKKPIP-------- 63
            +KL  +S+++   + KN   +QQ   ++ RK   K   A++   A +KK +         
Sbjct: 1330 QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIES 1389

Query: 64   LENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAK 123
            LE  K+K         +  EE+AL  D +++   +L ++L      LT DL     V + 
Sbjct: 1390 LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD----LTVDLDHQRQVASN 1445

Query: 124  KRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEE 183
              K ++  D         Q   E++ I     +++     + REK  T +       EE 
Sbjct: 1446 LEKKQKKFD---------QLLAEEKSISARYAEERDRAEAEAREKE-TKALSLARALEEA 1495

Query: 184  RELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSML 243
             E +EE      Q     E L+  K  +  K +H    +   L       ++++E+R+ L
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVG-KNVHELEKSKRALE------QQVEEMRTQL 1548

Query: 244  MEQDPDVAVTV-RKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLV 302
             E + ++  T   KL +   M+  K            + E+  +TR E  +  E +  L+
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQAMK-----------AQFERDLQTRDEQNE--EKKRLLI 1595

Query: 303  SQYKFYLENLEQMVKDWKQRKL----KKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNF 358
             Q +     LE    + KQR L    KK   + LK  +   E A K+  E++  L     
Sbjct: 1596 KQVRELEAELED---ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQA 1652

Query: 359  HNNIIVLIVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRP 418
                       M D  + + E       ++F Q K  +  L  ++           +++ 
Sbjct: 1653 Q----------MKDYQRELEEARASR-DEIFAQSKESEKKLKSLEA-------EILQLQE 1694

Query: 419  EMLKTFLCLRIKEVEVKKDTEDINKPK--KFMTFKEKRKSLSRMQRKWKKAEEKLERELR 476
            E+  +    R  E E  +  ++I      K     EKR    R++ +  + EE+LE E  
Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSALLDEKR----RLEARIAQLEEELEEEQS 1750

Query: 477  EAEASESTEKKLKLHTETLN 496
              E      +K  L  +TLN
Sbjct: 1751 NMELLNDRFRKTTLQVDTLN 1770


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 57/291 (19%), Positives = 124/291 (42%), Gaps = 45/291 (15%)

Query: 25  ENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEE 84
           E K+  ++ K Q   +K ++++ K+R+  +    ++ +  E  ++ R  + +  E+EE+ 
Sbjct: 287 EEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI 346

Query: 85  EALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTA 144
             L   M +++ ++  ++  Q    +       E      R+ E+I ++ EKI       
Sbjct: 347 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI------- 399

Query: 145 PEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHL 204
                      +++  ++ +  EK      K  E +EE +E EE++          EE +
Sbjct: 400 -----------REQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQ-------EEKI 441

Query: 205 IERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLME 264
            E++KK++E++                  +K++E   M+ EQ+  +     K+       
Sbjct: 442 REQEKKIREQE------------------EKIREQEEMMQEQEEKMGEQEGKMCEQEAKM 483

Query: 265 LFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQM 315
             ++     +   + E EK  K R++ +K+RE EE +  Q +   E  E+M
Sbjct: 484 QEQEEKMRRQEEKIREQEK--KIREQEEKIREQEEMMQEQEEKMWEQEEKM 532



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 39/201 (19%), Positives = 97/201 (48%), Gaps = 9/201 (4%)

Query: 18  KTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIE 77
           K  K++ + ++  ++ ++   L++   EQ K+R+  +    ++ I  +  ++++  K   
Sbjct: 328 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 387

Query: 78  REE---EEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKY 134
           +EE   E+EE+    + M ++  + M +  Q      ++    E     +R+ E+I ++ 
Sbjct: 388 QEEKIREQEEKIREQEEMMQEQEEKMGE--QEEKMWEQEEEMQEQEEKMRRQEEKIREQE 445

Query: 135 EKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDP 194
           +KI    +   E+E +    ++++   + +   K      K +E +E+ R  EE+I E  
Sbjct: 446 KKIREQEEKIREQEEM----MQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQE 501

Query: 195 IQELTIEEHLIERKKKLQEKK 215
            +    EE + E+++ +QE++
Sbjct: 502 KKIREQEEKIREQEEMMQEQE 522



 Score = 38.5 bits (88), Expect = 0.025
 Identities = 43/215 (20%), Positives = 99/215 (46%), Gaps = 39/215 (18%)

Query: 2   KARRNKKQIPSFRKLIKTSKVKL---ENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVS 58
           K R  +++I    ++++  + K+   E K+  ++ + Q   +K R+++ K+R+       
Sbjct: 391 KIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIRE------- 443

Query: 59  KKPIPLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSE 118
                    +EK+  ++ E+  E+EE      MM E + ++ +  G+      ++    E
Sbjct: 444 ---------QEKKIREQEEKIREQEE------MMQEQEEKMGEQEGKMCE---QEAKMQE 485

Query: 119 PVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEE 178
                +R+ E+I ++ +KI    +   EK       I+++  ++ +  EK      K  E
Sbjct: 486 QEEKMRRQEEKIREQEKKI----REQEEK-------IREQEEMMQEQEEKMWEQEEKMCE 534

Query: 179 DQEEERELEEEIIEDPIQELTIEEHLIERKKKLQE 213
            +E+ +E EE++     +    E  L ++++K+QE
Sbjct: 535 QEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569



 Score = 33.9 bits (76), Expect = 0.61
 Identities = 38/189 (20%), Positives = 78/189 (41%), Gaps = 14/189 (7%)

Query: 159 SGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHI 218
           +G + Q      T   K +   EE  +  + +  +  +    +E L E+  KLQEK   +
Sbjct: 162 AGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLV 221

Query: 219 AALASAILSDPENNIKKLKELRSMLMEQDPDV----------AVTVRKLVIVSLMELFKD 268
            +  S I  + +   +KL+  + +L +Q              +V+ +    V   EL+  
Sbjct: 222 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 281

Query: 269 ITPSYKIRPLTEAEK----STKTRKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRKL 324
           +    + +   + EK      K +++ +K+RE EE +  Q +   E  E+M +  +    
Sbjct: 282 LNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 341

Query: 325 KKSNVVSLK 333
           K+  +  L+
Sbjct: 342 KEEKIRELE 350


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 65/332 (19%), Positives = 143/332 (43%), Gaps = 48/332 (14%)

Query: 5   RNKKQIPSFRKLIKTSKVKL---ENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKP 61
           R ++++    K I+  + K+   E +L+ ++ K +   +K R+++++LR+  K+      
Sbjct: 238 RQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKEL----- 292

Query: 62  IPLENPKEKRPGKRIEREEE--EEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEP 119
              E  KE R  K++  +EE  +E+E    +  ++   Q  K   Q      ++    E 
Sbjct: 293 --REQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ 350

Query: 120 VHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEED 179
               + + ER+ ++ E++    +   E+E +     K +     + REK + +  +   +
Sbjct: 351 EQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMRE 410

Query: 180 QEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKEL 239
           QEE+ + +EE + +  ++   ++ L E+K+KL E+                   +K++E 
Sbjct: 411 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ-------------------EKMQEQ 451

Query: 240 RSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEA-----EKSTKTRKETQKL 294
              + EQ+  +             E++      ++   + E      E+  K R + QK+
Sbjct: 452 EEKIWEQEEKIR---------DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 502

Query: 295 REFEEGLVSQYKFYLENLEQM---VKDWKQRK 323
            + EE +  Q +   E  E+M    K W+Q +
Sbjct: 503 WDQEERMWEQDERLREKEERMREQKKMWQQEE 534



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 57/317 (17%), Positives = 133/317 (41%), Gaps = 7/317 (2%)

Query: 2   KARRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKP 61
           K  R ++Q   + +  K  + +   + + K  +++ T+++  ++ +K  + + +   K+ 
Sbjct: 371 KEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEW 430

Query: 62  IPLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLM---KDLGQRVSFLTRDLSSSE 118
                P++K      E+ +E+EE+    +    D  ++    K + ++     ++    E
Sbjct: 431 QQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWE 490

Query: 119 PVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEE 178
                + + +++ D+ E++    +   EKE       K          EK   +  K   
Sbjct: 491 QEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTW 550

Query: 179 DQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKE 238
           DQEE+   EE + E   +    EE + E+++K+QE++  +      +    E    K++E
Sbjct: 551 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEE----KMQE 606

Query: 239 LRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFE 298
               + EQ+  +     +  +    E+  +     + +     E+  K R++ +K+RE E
Sbjct: 607 QEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQE 666

Query: 299 EGLVSQYKFYLENLEQM 315
           E +  Q +   E  E+M
Sbjct: 667 EKMQGQEEKMREQEEKM 683



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 63/328 (19%), Positives = 147/328 (44%), Gaps = 37/328 (11%)

Query: 2   KARRNKKQIPSFRKLIKTSKVKLENKLKN------KQFKQQSTLKKYRK--EQRKLRQAV 53
           + R  +K++    + ++  + K++ + +N      K+++QQ   ++  K  EQ K+++  
Sbjct: 393 RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ- 451

Query: 54  KDAVSKKPIPLENPKE----KRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSF 109
           ++ + ++   + + +E    ++   R E+  E+E++    +    D  Q M D  +R+  
Sbjct: 452 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWE 511

Query: 110 LTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKP 169
               L   E    + R+ +++  + EK+    +T  +++       K +     + REK 
Sbjct: 512 QDERLREKEE---RMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKK 568

Query: 170 VTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDP 229
           + +  +   +QEE+ + +EE + +       EE + E+++K+QE++  +      +    
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMREQ------EEKMWEQEEKMQEQEEKMWEQEEKMWEQE 622

Query: 230 ENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEA--EKSTKT 287
           E +  K++E   M+ EQ+  +     K+                K+R   E   E+  K 
Sbjct: 623 EED--KMQEQEEMMWEQEEKMQEQEEKMW-----------EQEEKMREQEEKMREQEEKM 669

Query: 288 RKETQKLREFEEGLVSQYKFYLENLEQM 315
           + + +K+RE EE +  Q +   E  E+M
Sbjct: 670 QGQEEKMREQEEKMQGQEEKMREQEEKM 697



 Score = 31.6 bits (70), Expect = 3.0
 Identities = 41/220 (18%), Positives = 101/220 (45%), Gaps = 25/220 (11%)

Query: 2   KARRNKKQIPSFRKLI-KTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDA--VS 58
           K R  KK     +K   +  K++ E +++ ++ K +   +  R+++ K+++  +      
Sbjct: 535 KMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQE 594

Query: 59  KKPIPLENPKEKRPGKRIEREE---EEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLS 115
           +K    E   +++  K  E+EE   E+EEE    D M E +  + +   Q      ++  
Sbjct: 595 EKMWEQEEKMQEQEEKMWEQEEKMWEQEEE----DKMQEQEEMMWE---QEEKMQEQEEK 647

Query: 116 SSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNK 175
             E     + + E++ ++ EK+    +   E+E        +K     Q +E+ + +  +
Sbjct: 648 MWEQEEKMREQEEKMREQEEKMQGQEEKMREQE--------EKM----QGQEEKMREQEE 695

Query: 176 DEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKK 215
               QEE+   +EE +    +++  +E + E++++++++K
Sbjct: 696 KMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQK 735



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 21/71 (29%), Positives = 41/71 (57%), Gaps = 3/71 (4%)

Query: 427 LRIKEVEVKKDTEDINKPKKFMTFKE--KRKSLSRMQRKWKKAEEKLERELREAEASEST 484
           LR +E +++K  E + + ++ +  +E   R+   +M+R+ K+  E+ E+ELRE E     
Sbjct: 243 LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQ-EKELREQEKELRE 301

Query: 485 EKKLKLHTETL 495
           +KKL+   E +
Sbjct: 302 QKKLREQEEQM 312


>gi|13129068 nucleolar complex associated 4 homolog [Homo sapiens]
          Length = 516

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 39/116 (33%), Positives = 58/116 (50%), Gaps = 5/116 (4%)

Query: 625 AFIKRLCTLALHVLPNSSIGILATTRILMHTFPKTDLLLD---SESQGSGVFLPELDEPE 681
           AF KRL  LAL   P + + +L     L+   P   +L+         +  + P  ++P 
Sbjct: 367 AFAKRLARLALTAPPEALLMVLPFICNLLRRHPACRVLVHRPHGPELDADPYDPGEEDPA 426

Query: 682 YCNAQNTALWELHALRRHYHPIVQRFAAHLIAGAPSEGSGALKPELSRRSATELFE 737
              A  ++LWEL AL+RHYHP V + AA +I  A S    ++ P L   +A E+FE
Sbjct: 427 QSRALESSLWELQALQRHYHPEVSK-AASVINQALSMPEVSIAP-LLELTAYEIFE 480


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 72/338 (21%), Positives = 132/338 (39%), Gaps = 51/338 (15%)

Query: 17   IKTSKVKLENKLKNKQFKQ---QSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPG 73
            ++  K   ENK+KN   +    +  + K  KE++ L++A +  +    +     +E +  
Sbjct: 968  VEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQV-----EEDKVN 1022

Query: 74   KRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEP----VHAKKRKHER 129
              I+   + E++   L+   E + +L  DL +    L  DL  S+     +   K++ E 
Sbjct: 1023 GLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEE 1082

Query: 130  IIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEE 189
             + K E     LQ   + E +H L  + K                  +E Q    ELEEE
Sbjct: 1083 KLKKKEFELSQLQAKIDDEQVHSLQFQKKI-----------------KELQARIEELEEE 1125

Query: 190  IIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLME---- 245
            I  +      IE+   +  ++L+E    +   + A  +  E N K+  E + M  +    
Sbjct: 1126 IEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEA 1185

Query: 246  --QDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKS----------------TKT 287
              Q    A T+RK    S+ EL + I    +++   E EKS                +K+
Sbjct: 1186 TLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKS 1245

Query: 288  RKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLK 325
            +   ++     E   S+ K   E   Q++ D   +K +
Sbjct: 1246 KSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKAR 1283



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 92/487 (18%), Positives = 195/487 (40%), Gaps = 48/487 (9%)

Query: 36   QSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEALPLDMMDED 95
            Q  L K   E  + R   +    ++   LE  K+K   +  E EE  E        +++ 
Sbjct: 1362 QRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKT 1421

Query: 96   DLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERII----DKYEKIPRTLQTAPEKELIH 151
              +L  ++   +  L R  ++   +  K+R  ++++     K ++    L+ A ++    
Sbjct: 1422 KQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSL 1481

Query: 152  LLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDP--IQELTIEEHLIERKK 209
               +        +  ++  T   +++  QEE  +L E+I E    +QE    + L+E++K
Sbjct: 1482 STELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEK 1541

Query: 210  K-----LQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKL-----VI 259
                  L+E +  +    S IL       +   EL   ++E+D ++    R        +
Sbjct: 1542 SDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEAL 1601

Query: 260  VSLMEL-FKDITPSYKIRPLTEAE---------KSTKTRKETQKLREFEEGLVSQYKFYL 309
             S+++   +    + +++   E +          S +   ETQK     +G +   + +L
Sbjct: 1602 QSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHL 1661

Query: 310  ENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPL 369
            ++  +  +D K++      +  ++   GL    ++ L E+ VAL        +    +  
Sbjct: 1662 DDALRSNEDLKEQ------LAIVERRNGLL---LEELEEMKVALEQTERTRRLSEQELLD 1712

Query: 370  MNDMSKLISEMCCEAV--KKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCL 427
             +D  +L+       +  KK  + D + Q    V   I    + RN E + +   T   +
Sbjct: 1713 ASDRVQLLHSQNTSLINTKKKLEAD-IAQCQAEVENSIQ---ESRNAEEKAKKAITDAAM 1768

Query: 428  RIKEVEVKKDTE-DINKPKKFM--TFKEKRKSLSRMQ----RKWKKAEEKLERELREAEA 480
              +E++ ++DT   + + KK +  T K+ +  L   +    +  KK  +KLE  +RE E 
Sbjct: 1769 MAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELEN 1828

Query: 481  SESTEKK 487
                E+K
Sbjct: 1829 ELDVEQK 1835



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 100/507 (19%), Positives = 202/507 (39%), Gaps = 47/507 (9%)

Query: 17   IKTSKVKLENKLKNKQFKQQSTLKK---YRKEQRKLRQAVKDAV-----SKKPIPLENPK 68
            ++ +K KL  +L+  +   ++   K     K +++L+  V+D +     S       + K
Sbjct: 1390 LEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKK 1449

Query: 69   EKRPGKRI-EREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAK-KRK 126
            ++   K + E +++ +E    L+   ++   L  +L +  +     +   E +  + K  
Sbjct: 1450 QRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNL 1509

Query: 127  HERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEEREL 186
             E I D  E+I  T +   E E    L  ++KS +  Q   + V  S + EE +    +L
Sbjct: 1510 QEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDL--QVALEEVEGSLEHEESKILRVQL 1567

Query: 187  EEEIIEDPIQELTIE--EHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLM 244
            E   ++  +    IE  E + + K+  Q     + ++  A +    + ++  K++   L 
Sbjct: 1568 ELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLN 1627

Query: 245  EQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPL--TEAEKSTKTRKETQKLREFEEGLV 302
            E +  +  + R++      +  + +    K   L   +A +S +  KE   + E   GL+
Sbjct: 1628 EMEIQLGHSNRQMA--ETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLL 1685

Query: 303  ----SQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNF 358
                 + K  LE  E+  +  +Q  L  S+ V L   +  + +  K   E  +A      
Sbjct: 1686 LEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEV 1745

Query: 359  HNNI------------IVLIVPLMNDMSKLISEMCC--EAVKKLFKQD------KLGQAS 398
             N+I             +    +M +  K   +     E +KK  +Q       +L +A 
Sbjct: 1746 ENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1805

Query: 399  LGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKE-VEVKKDTEDINKPKKFMTFK--EKRK 455
               +K   G  + +  E R   L+  L +  K   E  K      +  K MT++  E  K
Sbjct: 1806 QLALK--GGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHK 1863

Query: 456  SLSRMQRKWKKAEEKLERELREAEASE 482
            ++ R+Q    K + K++   R+AE +E
Sbjct: 1864 NILRLQDLVDKLQAKVKSYKRQAEEAE 1890



 Score = 34.3 bits (77), Expect = 0.47
 Identities = 56/252 (22%), Positives = 105/252 (41%), Gaps = 34/252 (13%)

Query: 94   EDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLL 153
            E ++  MK+  +R      +L+ SE    +K   E+++   ++    LQ   + E  +L+
Sbjct: 850  EKEMATMKEDFERTK---EELARSEA--RRKELEEKMVSLLQE-KNDLQLQVQSETENLM 903

Query: 154  PIKD------KSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIER 207
              ++      KS I+ + + K +T+  ++EE+   E   ++  +ED    L  +   +E 
Sbjct: 904  DAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLEL 963

Query: 208  KKKLQEKKMHIAALASAILSDP----ENNIKKLKELRSMLMEQD----PDVAVTVRKL-- 257
                 EK+ H        LS+     E NI KL + +  L E       D+ V   K+  
Sbjct: 964  TLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNG 1023

Query: 258  ---VIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQ 314
               +   L +   D+  S +      A+     RK    L+  +E ++      LEN +Q
Sbjct: 1024 LIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMD-----LENDKQ 1078

Query: 315  MVKDWKQRKLKK 326
             +++    KLKK
Sbjct: 1079 QIEE----KLKK 1086


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 96/478 (20%), Positives = 190/478 (39%), Gaps = 64/478 (13%)

Query: 2    KARRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKP 61
            K +  K+ + +    +K    K+ + LKN + + +   +K +     L +  K+   +  
Sbjct: 843  KVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQ 902

Query: 62   IPLENP--KEKRPGKRIEREEEEEEEA-LPLDMMDEDDLQLMKDLGQRVSF---LTRDLS 115
            + +EN   ++K   K +E+E+E   +  L L+ M E  +Q    L Q       L  +++
Sbjct: 903  VQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNIN 962

Query: 116  SSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNK 175
              +    +K+K    +    KI    +T  E +L   L    +   +   +EK     N 
Sbjct: 963  ELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQE--LAAEKEKISVLQNN 1020

Query: 176  DEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKK 235
             E+ QE  ++L+ +      + L   + L   ++KL   +  + +  + I     N  K 
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQI----GNQNKL 1076

Query: 236  LKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLR 295
            ++EL++     + D A   ++L      E  K +    K + L E E       E  KL 
Sbjct: 1077 IQELKTAKATLEQDSAKKEQQL-----QERCKALQDIQKEKSLKEKELVN----EKSKLA 1127

Query: 296  EFEEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPH 355
            E EE    Q K  +  L + +K  K   +K+  + +LK  K           +LL+    
Sbjct: 1128 EIEEIKCRQEK-EITKLNEELKSHKLESIKE--ITNLKDAK-----------QLLI---- 1169

Query: 356  FNFHNNIIVLIVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYE 415
                               KL  +   +++K   +Q+K  Q      +++   VK    E
Sbjct: 1170 -----------------QQKLELQGKADSLKAAVEQEKRNQ------QILKDQVKKEEEE 1206

Query: 416  VRPEMLKTFLCLR--IKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKL 471
            ++ E ++    L   IKE EV     + N+ K  M      ++L  ++++W+ ++ ++
Sbjct: 1207 LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRV 1264



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 69/323 (21%), Positives = 134/323 (41%), Gaps = 35/323 (10%)

Query: 28  LKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEAL 87
           LK +  + Q+ +     E+ +  + +KD   K      + +      R E  +  +E A+
Sbjct: 226 LKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAV 285

Query: 88  PLDMMDEDDLQLMK----DLGQRVSFLTRDLSSSEPVHAK-KRKHERIIDKYEKIPRTLQ 142
            +      +LQ +K    +L Q+   LT +L   E  + K + KH       + I  TL 
Sbjct: 286 YVQ-----ELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLH 340

Query: 143 TAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEE 202
              +K+L         S          V  S K E  Q+    L+EE+ E   +   ++ 
Sbjct: 341 ---QKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK----LKEELSEVETKYQHLKA 393

Query: 203 HLIERKKKLQEKKMHIAALASAI------LSDPENNI----KKLKELRSMLMEQ--DPDV 250
              + +++ +EK+ H   L S I      L + E  +     +LKE R +  E+  D + 
Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453

Query: 251 AVTVRKLVIVSLMELFKDITPSYKIRPLTEAE-KSTKTRKETQKLREFEEGLVSQYKFYL 309
            V   +L +  L E  K+     K+   TE + +  KT+++ Q+ +  ++   ++ +   
Sbjct: 454 QVADLQLKLSRLEEQLKE-----KVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQ 508

Query: 310 ENLEQMVKDWKQRKLKKSNVVSL 332
            +LEQ+++    +  K  N+ +L
Sbjct: 509 NDLEQVLRQIGDKDQKIQNLEAL 531


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 64/332 (19%), Positives = 146/332 (43%), Gaps = 31/332 (9%)

Query: 25   ENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEE 84
            E K KN++ K +   +K ++ Q  L++ + D  +K    LEN   +        ++E++ 
Sbjct: 946  ETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALEL------SQKEKQF 999

Query: 85   EALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTA 144
             A  L+M   +   +   + +  +     + S   VH  +R+   +I  +EK  +  Q A
Sbjct: 1000 NAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVH--RRELNDVISIWEK--KLNQQA 1055

Query: 145  PEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHL 204
             E + IH + +++K   + + ++K +    + EE  +E   L+EE ++   Q+ T+    
Sbjct: 1056 EELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVK---QDTTLN--- 1109

Query: 205  IERKKKLQEKKMHIAALA------SAILSDPENNIKKLKELRSMLMEQDPDVAVTVR--K 256
             E +++L++K  H+ +LA       A L   E ++ K  +  + L EQ  ++ +     K
Sbjct: 1110 -ELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK 1168

Query: 257  LVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQMV 316
              +  L    K     ++    +  + +     ++ + ++  E L  Q     +  E ++
Sbjct: 1169 RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALL 1228

Query: 317  KDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCE 348
                  + K + ++++ + K  A ++  S C+
Sbjct: 1229 ------EAKTNELINISSSKTNAILSRISHCQ 1254



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 120/553 (21%), Positives = 217/553 (39%), Gaps = 101/553 (18%)

Query: 5   RNKKQIPSFRKLIKTSKVKLENKLKNKQF--KQQSTLKKYRKEQRKLRQAVKDAVSKKP- 61
           R K+++    K     ++    KL  K+   K+Q   KK +  +R+ ++ +K A+ K   
Sbjct: 461 RVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQS 520

Query: 62  --IPLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKD-----LGQRVSFLTRDL 114
             + +   KE++    +E  E +++  L        DLQ   +     + +  S L + L
Sbjct: 521 EYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSL 580

Query: 115 SSSE------PVH--AKKRKHERII-----------------------DKYEKIPRTLQT 143
             ++       VH  A+K KH + I                       +K + + +  QT
Sbjct: 581 QENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQT 640

Query: 144 APEK-----ELIHLLPIKDKSGIIPQTREKPVTDSNKDEED--QEEERELEEEIIEDPIQ 196
             EK     E      +KDK  II Q   + + +   ++ D  Q E   L  E+ E    
Sbjct: 641 EMEKLREKCEQEKETLLKDKE-IIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKA 699

Query: 197 ELTIEEHLI-----------ERKKKLQEKKMHIAALASAILSDPENNIKK--------LK 237
              +EE L            E + K+ E+K H      +I+ + E +I++        + 
Sbjct: 700 RHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQIN 759

Query: 238 ELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREF 297
           +L  +L E+D  +     K     +  L  DI  S       E E    + K     + +
Sbjct: 760 QLELLLKERDKHL-----KEHQAHVENLEADIKRS-------EGELQQASAK-LDVFQSY 806

Query: 298 EEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAV--KSLCELLVALPH 355
           +     Q K Y E L Q+     Q+KL       +   K +AEV    K +C  L A   
Sbjct: 807 QSATHEQTKAYEEQLAQL-----QQKLLDLETERILLTKQVAEVEAQKKDVCTELDA--- 858

Query: 356 FNFHNNIIVLIVPLMNDMSKLISEMCCEAVKKLFK--QDKLGQASLGVIKVISGFVKGRN 413
              H    + +  LM  + K  SEM  + VK L +  + KL   +    +     V+  N
Sbjct: 859 ---HK---IQVQDLMQQLEKQNSEME-QKVKSLTQVYESKLEDGNKEQEQTKQILVEKEN 911

Query: 414 YEVRP-EMLKTFLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLE 472
             ++  E  K  + +  +++  K+D+  I   +    FK + K + ++++K K+ +E L+
Sbjct: 912 MILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLK 971

Query: 473 RELREAEASESTE 485
           ++L + EA    E
Sbjct: 972 KKLLDQEAKLKKE 984



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 65/337 (19%), Positives = 141/337 (41%), Gaps = 31/337 (9%)

Query: 7    KKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLEN 66
            K+++    K     K ++E+  K+K  K++S L+   K Q      ++D +++K I +E+
Sbjct: 1485 KEELDQQNKRFDCLKGEMEDD-KSKMEKKESNLETELKSQTARIMELEDHITQKTIEIES 1543

Query: 67   PKEKRPGKRIEREEEEEEEALPLDM---MDEDDLQLMKDLGQRVSFLTRDLSSSEP-VHA 122
              E       +++ E +E    L     + E+    +K+  +++  L   + S +  +  
Sbjct: 1544 LNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET 1603

Query: 123  KKRKHERI---IDKYEKIPRTLQTAPEKE-LIHLLPIKDKSGIIPQTREKPVTDSNKDEE 178
            KK++ E +   +   E+  + L+   E E    L  +K K+       E+ +    K   
Sbjct: 1604 KKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKA-------EQKIAAIKKQLL 1656

Query: 179  DQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKL-- 236
             Q EE+E +         +   E HL E   KLQE++  +  L   + S   +  + L  
Sbjct: 1657 SQMEEKEEQ--------YKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIV 1708

Query: 237  ----KELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQ 292
                K + +   +++ D    V+K     +  L +++T   K+      EK        +
Sbjct: 1709 PRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFE 1768

Query: 293  KLREFEEGLVS-QYKFYLENLEQMVKDWKQRKLKKSN 328
               +++E L+  ++    ++ +Q +    Q +L++ N
Sbjct: 1769 MRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKN 1805



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 72/331 (21%), Positives = 141/331 (42%), Gaps = 59/331 (17%)

Query: 4   RRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIP 63
           R   KQ+ +  + ++  K K E     +  K  ST +K  + +RKL+  + + +      
Sbjct: 388 RSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQI------ 441

Query: 64  LENPKEKRPGKRIEREEEEEEEAL--PLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVH 121
                     K IE+  EEE  +L   L  + ++ + +MK             SS E + 
Sbjct: 442 ----------KTIEKTSEEERISLQQELSRVKQEVVDVMKK------------SSEEQIA 479

Query: 122 AKKRKHER-IIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQ 180
             ++ HE+ +  K +++ + LQT  E+E    + +           EK  ++  K  +++
Sbjct: 480 KLQKLHEKELARKEQELTKKLQTR-EREFQEQMKV---------ALEKSQSEYLKISQEK 529

Query: 181 EEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELR 240
           E++  L  E +E  +Q+  I   L E + KL++ +       + IL    +  K L+E +
Sbjct: 530 EQQESLALEELE--LQKKAI---LTESENKLRDLQQEAETYRTRILELESSLEKSLQENK 584

Query: 241 SMLMEQDPDVAVTVRKLVIVSLMELFKDITPSY-KIRPLTEAEKSTKTRKETQKLREFEE 299
           +    Q  D+AV +         +  K+IT    K +   E+ K  +    T+KL+  ++
Sbjct: 585 N----QSKDLAVHLE----AEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQ 636

Query: 300 GLVSQYKFYLENLEQMVKDWKQRKLKKSNVV 330
               QY+  +E L +  +  K+  LK   ++
Sbjct: 637 ----QYQTEMEKLREKCEQEKETLLKDKEII 663



 Score = 38.5 bits (88), Expect = 0.025
 Identities = 115/575 (20%), Positives = 222/575 (38%), Gaps = 110/575 (19%)

Query: 2   KARRNKKQIPSFR----------KLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQ 51
           + RR ++ + S+R          ++++  K KL+  L   Q K    + + R+E +  +Q
Sbjct: 142 RLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQ 201

Query: 52  AVKDAVSKKPIPLEN--------------------------------PKEKRPGKRIERE 79
           A K    +    LE                                 P+ +   +   +E
Sbjct: 202 AKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKE 261

Query: 80  EEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLS-SSEPVHAKKRKHERIIDKYEKIP 138
           E  E +  P+ + D   ++ ++ L QRV      L    E + + K +   +  + E + 
Sbjct: 262 ENPESDGEPV-VEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQ 320

Query: 139 RTL-QTAPEKELIHLLPIKDKSGIIPQTREK----PVTDSNKDEEDQEEERELEE--EII 191
             L +   E E I  L + +K+ +I Q R+        + +K     E +R++ E  E+ 
Sbjct: 321 EQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMK 380

Query: 192 EDPIQELTIE-EHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDV 250
           E+ I +L    + +  + ++L+E+K      A   L    +  +K +E R  L  +  + 
Sbjct: 381 EEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQ 440

Query: 251 AVTVRKLVIVSLMELFKDIT----------------PSYKIRPLTEAEKSTKTRKETQKL 294
             T+ K      + L ++++                   K++ L E E + K ++ T+KL
Sbjct: 441 IKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKL 500

Query: 295 ----REFEEGL-------------VSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKG 337
               REF+E +             +SQ K   E+L     + +++ +   +   L+  + 
Sbjct: 501 QTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQ 560

Query: 338 LAEVAVKSLCELLVAL-----PHFNFHNNIIVLIVPLMNDMSKLISEMC----CEAVKKL 388
            AE     + EL  +L      + N   ++ V +    N  +K I+ M      E     
Sbjct: 561 EAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLK 620

Query: 389 FKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLK------TFLCLRIKEVEVKKDTEDIN 442
            +QD L    L V+K        + Y+   E L+          L+ KE+  +   E++N
Sbjct: 621 HQQDALWTEKLQVLK--------QQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMN 672

Query: 443 KP--KKFMTFKEKRKSLSRMQRKWKKAEEKLEREL 475
           +   +K    + + +SLS    +  KA  KLE EL
Sbjct: 673 EKTLEKLDVKQTELESLSSELSEVLKARHKLEEEL 707



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 94/496 (18%), Positives = 207/496 (41%), Gaps = 83/496 (16%)

Query: 15   KLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGK 74
            K+ +  + K++ +  + Q +  S +K++    ++  +A+KD +++  + L+         
Sbjct: 716  KMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLK--------- 766

Query: 75   RIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKY 134
              ER++  +E    ++ ++ D  +   +L Q  + L    S     H + + +E      
Sbjct: 767  --ERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYE------ 818

Query: 135  EKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVT-DSNKDE-EDQEEERELEEEIIE 192
            E++ +  Q   + E   +L  K  + +  Q ++     D++K + +D  ++ E +   +E
Sbjct: 819  EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878

Query: 193  DPIQELT-IEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVA 251
              ++ LT + E  +E   K QE+          IL + EN I +++E       Q  ++ 
Sbjct: 879  QKVKSLTQVYESKLEDGNKEQEQ-------TKQILVEKENMILQMRE------GQKKEIE 925

Query: 252  VTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLRE-FEEGLVSQ---YKF 307
            +  +KL      +    +   Y+ +   + +K  K +++ ++++E  ++ L+ Q    K 
Sbjct: 926  ILTQKLSAKE--DSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKK 983

Query: 308  YLEN----LEQMVKDWKQRKLK--KSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNN 361
             LEN    L Q  K +  + L+  ++N   +       E   K   E L  + H    N+
Sbjct: 984  ELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEV-HRRELND 1042

Query: 362  IIVLIVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEML 421
            +I +    +N  ++ + E+    ++   K+ ++ +    ++  + G  K        EM 
Sbjct: 1043 VISIWEKKLNQQAEELQEI--HEIQLQEKEQEVAELKQKIL--LFGCEK-------EEMN 1091

Query: 422  KTFLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERELREAEAS 481
            K    L  KE  VK+DT                 +L+ +Q       E+L+++     + 
Sbjct: 1092 KEITWL--KEEGVKQDT-----------------TLNELQ-------EQLKQKSAHVNSL 1125

Query: 482  ESTEKKLKLHTETLNI 497
               E KLK H E L +
Sbjct: 1126 AQDETKLKAHLEKLEV 1141


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 62/280 (22%), Positives = 127/280 (45%), Gaps = 16/280 (5%)

Query: 51  QAVKDAVSKKPIPLE-NPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLG-QRVS 108
           ++V  +  K+  PL  +PKEK   +      +EE E L    ++ED  + ++++  +R  
Sbjct: 513 RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 572

Query: 109 FLTRDLSSSEPV-HAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTRE 167
            L + L + E V   K+ K ++I  K+ +I    + A E+ L      K  +      + 
Sbjct: 573 RLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAA----KKM 628

Query: 168 KPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILS 227
           + V    K EE+    R L++E      +E    + L+++KK+ +++++  AA A  +  
Sbjct: 629 EEVEARRKQEEEARRLRWLQQE------EEERRHQELLQKKKEEEQERLRKAAEAKRLAE 682

Query: 228 DPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKT 287
             E   ++ +       EQ+        +   ++  E  ++       R L E EK+ + 
Sbjct: 683 QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRL 742

Query: 288 RKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLKKS 327
           +KE Q  RE EE    + +  L   E+ +++ +++K K++
Sbjct: 743 QKE-QLQRELEEKKKKEEQQRL--AERQLQEEQEKKAKEA 779



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 46/245 (18%), Positives = 115/245 (46%), Gaps = 22/245 (8%)

Query: 4   RRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIP 63
           RR ++     R+ ++  K +   ++K K+ ++   + + R+   ++++  K  + +K   
Sbjct: 542 RRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ 601

Query: 64  LENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAK 123
           ++   EK   +R+  EE+ +++A    M + +  +  ++  +R+ +L ++         +
Sbjct: 602 IDEKTEKAKEERLA-EEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE--------EE 652

Query: 124 KRKHERIIDKY--EKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQE 181
           +R+H+ ++ K   E+  R  + A  K L      + +       +E+   +  + E  ++
Sbjct: 653 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE------QERREQERREQERREQ 706

Query: 182 EERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRS 241
           E RE E ++ E   QE   E+  ++ +++LQE++  +      +  + E   KK KE + 
Sbjct: 707 ERREQERQLAE---QERRREQERLQAERELQEREKALRLQKEQLQRELEE--KKKKEEQQ 761

Query: 242 MLMEQ 246
            L E+
Sbjct: 762 RLAER 766



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 42/217 (19%), Positives = 101/217 (46%), Gaps = 22/217 (10%)

Query: 1   MKARRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKK 60
           +K     +++   R+ ++  K + + +++ K  +     +K ++E+    +A K A +KK
Sbjct: 568 LKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKK 627

Query: 61  PIPLE-NPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEP 119
              +E   K++   +R+   ++EEEE    +++ +   +  + L        R  + ++ 
Sbjct: 628 MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL--------RKAAEAKR 679

Query: 120 VHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEED 179
           + A++R+ ER   +  +  R  Q   E+E               Q R+    +  +++E 
Sbjct: 680 L-AEQREQERREQERREQERREQERREQERRE------------QERQLAEQERRREQER 726

Query: 180 QEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKM 216
            + EREL+E      +Q+  ++  L E+KKK +++++
Sbjct: 727 LQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRL 763


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 100/494 (20%), Positives = 200/494 (40%), Gaps = 62/494 (12%)

Query: 36   QSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEALPLDMMDED 95
            Q  L K   E  + R   +    ++   LE  K+K   +  E EE  E        +++ 
Sbjct: 1358 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT 1417

Query: 96   DLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERII----DKYEKIPRTLQTAPEKELIH 151
              +L  ++   +  + R  +++  +  K+R  ++I+     KYE+    L+++ ++    
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL 1477

Query: 152  LLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKL 211
               +        ++ E   T   +++  QEE  +L E++        TI E L + +K+L
Sbjct: 1478 STELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSG---KTIHE-LEKVRKQL 1533

Query: 212  QEKKMHIAAL---ASAILSDPENNIKKLK--------ELRSMLMEQDPDVAVTVRK-LVI 259
            + +KM + +    A A L   E  I + +        E+   L E+D ++    R  L +
Sbjct: 1534 EAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRV 1593

Query: 260  VSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQMVKDW 319
            V  ++              T  +  T++R E  ++++  EG +++ +  L +  +M  + 
Sbjct: 1594 VDSLQ--------------TSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAE- 1638

Query: 320  KQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVL-------IVPLMND 372
              +K  KS    LK  +   + AV++  +L   +      NN++         +V     
Sbjct: 1639 -AQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTER 1697

Query: 373  MSKLISEMCCEAVKK----------LFKQDKLGQASLGVIK--VISGFVKGRNYEVRPEM 420
              KL  +   E  ++          L  Q K   A L  ++  V     + RN E + + 
Sbjct: 1698 SRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKK 1757

Query: 421  LKTFLCLRIKEVEVKKDTE-DINKPKKFM--TFKEKRKSLSRMQ----RKWKKAEEKLER 473
              T   +  +E++ ++DT   + + KK M  T K+ +  L   +    +  KK  +KLE 
Sbjct: 1758 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEA 1817

Query: 474  ELREAEASESTEKK 487
             +RE E     E+K
Sbjct: 1818 RVRELENELEAEQK 1831



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 99/498 (19%), Positives = 200/498 (40%), Gaps = 87/498 (17%)

Query: 2    KARRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAV---- 57
            K   ++ ++ S +K  ++   +L  KLKN   +    L+ +++E + L++ + D      
Sbjct: 1459 KYEESQSELESSQKEARSLSTELF-KLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517

Query: 58   -SKKPI-PLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLS 115
             S K I  LE  +++   +++E +   EE    L+  +   L+   +  Q  + + R L+
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1577

Query: 116  SS-EPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSN 174
               E +   KR H R++D       +LQT+ + E               ++R + +    
Sbjct: 1578 EKDEEMEQAKRNHLRVVD-------SLQTSLDAET--------------RSRNEALRVKK 1616

Query: 175  KDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIK 234
            K E D  E                 +E  L    +   E +  + +L S +L D +  + 
Sbjct: 1617 KMEGDLNE-----------------MEIQLSHANRMAAEAQKQVKSLQS-LLKDTQIQLD 1658

Query: 235  KLKELRSMLMEQDPDVAVTVRK--LVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQ 292
                    L E   ++A+  R+  L+   L EL   +  + + R L E E   +T +  Q
Sbjct: 1659 DAVRANDDLKE---NIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQEL-IETSERVQ 1714

Query: 293  KLREFEEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVA 352
             L      L++Q K    +L Q+  + ++         +++  +   E A K++ +  + 
Sbjct: 1715 LLHSQNTSLINQKKKMDADLSQLQTEVEE---------AVQECRNAEEKAKKAITDAAMM 1765

Query: 353  LPHFNFHNNIIVLIVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGR 412
                    +    +  +  +M + I ++          Q +L +A    +K   G  + +
Sbjct: 1766 AEELKKEQDTSAHLERMKKNMEQTIKDL----------QHRLDEAEQIALK--GGKKQLQ 1813

Query: 413  NYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKKF------MTFK--EKRKSLSRMQRKW 464
              E R   L+  L     E E K++ E +   +K       +T++  E RK+L R+Q   
Sbjct: 1814 KLEARVRELENEL-----EAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLV 1868

Query: 465  KKAEEKLERELREAEASE 482
             K + K++   R+AE +E
Sbjct: 1869 DKLQLKVKAYKRQAEEAE 1886



 Score = 37.0 bits (84), Expect = 0.072
 Identities = 64/336 (19%), Positives = 133/336 (39%), Gaps = 47/336 (13%)

Query: 17   IKTSKVKLENKLKNKQFKQ---QSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPG 73
            ++  K   ENK+KN   +       + K  KE++ L++A + A+       +        
Sbjct: 964  VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKA 1023

Query: 74   K-RIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLS-SSEPVHAKKRKHERII 131
            K ++E++ ++ E +L      E + ++  DL +    L  DL  + E +   +   +++ 
Sbjct: 1024 KVKLEQQVDDLEGSL------EQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLD 1077

Query: 132  DKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEII 191
            ++ +K    L     +       I+D+  +  Q ++K        +E Q    ELEEE+ 
Sbjct: 1078 ERLKKKDFELNALNAR-------IEDEQALGSQLQKKL-------KELQARIEELEEELE 1123

Query: 192  EDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLME------ 245
             +      +E+   +  ++L+E    +     A     E N K+  E + M  +      
Sbjct: 1124 AERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATL 1183

Query: 246  QDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKS----------------TKTRK 289
            Q    A  +RK    S+ EL + I    +++   E EKS                 K + 
Sbjct: 1184 QHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1243

Query: 290  ETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLK 325
              +K+    E  +++++   E  ++ V D   ++ K
Sbjct: 1244 NLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK 1279


>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
           sapiens]
          Length = 929

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 63/260 (24%), Positives = 113/260 (43%), Gaps = 30/260 (11%)

Query: 2   KARRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKP 61
           K    K ++PS  ++ K  K +L+ K+K K+ KQ+   ++  K++ K +   KD V +K 
Sbjct: 507 KVYEEKTKLPSSVEVKKKLKKELKTKMKKKE-KQRD--REREKDKNKDKSKEKDKVKEKE 563

Query: 62  IPLENPKE-KRPGKRIEREEEEEEEALPLDMMDEDD--LQLMKDLGQRVSFLTRDLSSSE 118
              E  +E K P K   +EEE +     +   ++ D  ++L   L ++     +D     
Sbjct: 564 KDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDR 623

Query: 119 PVHAK---KRKHERIIDKYE----KIPRTLQTAPEKELIHLLPIKDKS----------GI 161
               K   KR+ E++ DK      K P      P KEL   LP+   +           +
Sbjct: 624 EKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKEL--ALPLFSPATASRVPAMLPSL 681

Query: 162 IPQTREKPVTDSNKDEE-----DQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKM 216
           +P   EK   +  K +E     D++E+++ +E+  E   +E   E+   E+++K +EK  
Sbjct: 682 LPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHK 741

Query: 217 HIAALASAILSDPENNIKKL 236
           H       +   P   I +L
Sbjct: 742 HEKIKVEPVALAPSPVIPRL 761



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 20/68 (29%), Positives = 37/68 (54%), Gaps = 10/68 (14%)

Query: 428 RIKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERELREAEASESTEKK 487
           ++KE E KKD ++          K+K+K   + +++ ++ +EK ERE RE E  +   +K
Sbjct: 695 KVKEKEKKKDKKE----------KKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEK 744

Query: 488 LKLHTETL 495
           +K+    L
Sbjct: 745 IKVEPVAL 752



 Score = 30.0 bits (66), Expect = 8.9
 Identities = 21/72 (29%), Positives = 38/72 (52%), Gaps = 5/72 (6%)

Query: 418 PEMLKTFLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERELRE 477
           P ML + L      V  +K  E+  K K+    K+K++   + +++ +K E++ E+E RE
Sbjct: 675 PAMLPSLL-----PVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKRE 729

Query: 478 AEASESTEKKLK 489
            E  E  ++K K
Sbjct: 730 REKREKEKEKHK 741


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 83/414 (20%), Positives = 176/414 (42%), Gaps = 52/414 (12%)

Query: 111 TRDLSSSEPVHAKKR--KHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREK 168
           T   ++++ + AK++   H++ +++ + +    Q   E   + +  +++K  +    ++K
Sbjct: 255 THSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDK 314

Query: 169 PVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSD 228
            V +SNK EE QE+E  +EE           +   +IE +KK  E K  +      +   
Sbjct: 315 KVENSNK-EEIQEKETIIEE-----------LNTKIIEEEKKTLELKDKLTTADKLLGEL 362

Query: 229 PENNIKKLKELRSMLME------QDPDVAVTVRKLV-IVSLMELFKDITPSYKIRPLTEA 281
            E  ++K +E+++M +E      ++   +  +++L+  V  ++        ++   +   
Sbjct: 363 QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 422

Query: 282 EKSTKTRKET----------QKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLKK-SNVV 330
           E+ T+ + E           Q++ + ++ L+ Q+   +E ++   K   +  L+  SN+ 
Sbjct: 423 EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT 482

Query: 331 SLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDMSKLISEMCC------EA 384
             +    L  VA+    EL + L   N           L  ++  ++ E C       + 
Sbjct: 483 VNEDQIKLMNVAIN---ELNIKLQDTNSQKE------KLKEELGLILEEKCALQRQLEDL 533

Query: 385 VKKL-FKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRI---KEVEVKKDTED 440
           V++L F ++++ +A   + +  S   +        E LK  +       KE+E+K + E 
Sbjct: 534 VEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEV 593

Query: 441 IN-KPKKFMTFKEKRKSLSRMQRKWKKAEEKLERELREAEASESTEKKLKLHTE 493
            N K K  M  KEK   L RM    +   E+L  +L  +   E ++ K  L  E
Sbjct: 594 TNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 78/430 (18%), Positives = 173/430 (40%), Gaps = 54/430 (12%)

Query: 80   EEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPV----HAKKRKHERIIDKYE 135
            E   E +  L+       +LM++  ++    T  L   E +    H + R  E++  +  
Sbjct: 1859 EAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELS 1918

Query: 136  KIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEE--EIIED 193
            K    +    +++ +    I++K+ II +  ++ +  SN+ +E + E+++++E  E++  
Sbjct: 1919 KAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSR 1978

Query: 194  PIQEL-----TIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDP 248
              + +      +E+ L++  +KL ++K+ +   A  +  D +  +K L          + 
Sbjct: 1979 QKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKAL----------EI 2028

Query: 249  DVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFY 308
            DV   V + + +                   E EK+T+     Q+ +  E+ L    KF 
Sbjct: 2029 DVEEQVSRFIEL-------------------EQEKNTELMDLRQQNQALEKQLEKMRKFL 2069

Query: 309  LENL--EQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLI 366
             E     +  +D  Q++++K     LK       ++     E+     H     +    +
Sbjct: 2070 DEQAIDREHERDVFQQEIQKLE-QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL 2128

Query: 367  VPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNY---EVRPEMLKT 423
            +     + + I E   E  K  F+  +L QA L            +++   E +PE+   
Sbjct: 2129 LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPEL--- 2185

Query: 424  FLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERELREAEASES 483
                   EV+++ + + I++ +K +T  E++    R + + K  E +      E +  ES
Sbjct: 2186 -----SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKES 2240

Query: 484  TEKKLKLHTE 493
            T +  +L  E
Sbjct: 2241 TTRLQELEQE 2250



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 68/317 (21%), Positives = 137/317 (43%), Gaps = 61/317 (19%)

Query: 7    KKQIPSFRKLIKTSKVKLENK---LKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIP 63
            ++QI   R+L+   K  ++ +   ++ +  ++   L K + E +   + V+D + K+   
Sbjct: 1966 QQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKA 2025

Query: 64   LENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAK 123
            LE   E++  + IE E+E+  E + L   ++    L K L +   FL           A 
Sbjct: 2026 LEIDVEEQVSRFIELEQEKNTELMDLRQQNQ---ALEKQLEKMRKFLDE--------QAI 2074

Query: 124  KRKHERII--DKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTRE-KPVTDSNKDEEDQ 180
             R+HER +   + +K+ + L+  P  +     PI +      QTRE + + +  K++ D+
Sbjct: 2075 DREHERDVFQQEIQKLEQQLKVVPRFQ-----PISEH-----QTREVEQLANHLKEKTDK 2124

Query: 181  EEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELR 240
              E  L +E ++  IQ         ER +++++ +  +  L  A+L   +   K      
Sbjct: 2125 CSELLLSKEQLQRDIQ---------ERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKH 2175

Query: 241  SMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEG 300
               +E  P++++ V+                        +AE+    RKE +++   EE 
Sbjct: 2176 FGAVEAKPELSLEVQ-----------------------LQAERDAIDRKE-KEITNLEEQ 2211

Query: 301  LVSQYKFYLENLEQMVK 317
            L  Q++  LEN  + V+
Sbjct: 2212 L-EQFREELENKNEEVQ 2227



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 72/341 (21%), Positives = 148/341 (43%), Gaps = 55/341 (16%)

Query: 6   NKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLE 65
           +++QI   R+ I   + KL     N+  K  ST++  + E       V  + S+K + L+
Sbjct: 540 SREQIQRARQTIAEQESKL-----NEAHKSLSTVEDLKAE------IVSASESRKELELK 588

Query: 66  NPKEKRPGKRIEREEEEEEEALPLDMMDEDD--------LQLMKDLGQRVSFLTRDLSSS 117
           +  E    K I+ E  E+E+   LD M E           QL+    + +S L  DL   
Sbjct: 589 HEAEVTNYK-IKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647

Query: 118 EPVHAKKRKHERIIDKYEKIP----------RTLQ-------TAPEKELIHLLPIKDKSG 160
             ++ +K K    I   ++I            T+Q       T   + ++ +  +KD   
Sbjct: 648 HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ 707

Query: 161 IIPQTREKPVT----DSNKDEE----DQEEERELEEEIIEDPIQELTIEEHLIERKKKLQ 212
            +  ++ + +T    +  K+ E    +++E+  LE+E+ E  ++   +E+ + E++  LQ
Sbjct: 708 SLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQ 767

Query: 213 EKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPS 272
           EK   + A  ++IL D +  ++ + ++ + + +++       R + + S+    KD    
Sbjct: 768 EKFAQLEA-ENSILKDEKKTLEDMLKIHTPVSQEE-------RLIFLDSIKSKSKDSVWE 819

Query: 273 YKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLE 313
            +I  L E  +  K  ++  +L E  E   + + F  +N E
Sbjct: 820 KEIEILIEENEDLK--QQCIQLNEEIEKQRNTFSFAEKNFE 858



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 105/539 (19%), Positives = 230/539 (42%), Gaps = 109/539 (20%)

Query: 2   KARRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQ---AVKDAVS 58
           K R++ ++I   ++L+ T +   +   K+ QF+     +  ++ QRKL Q    + +   
Sbjct: 386 KERQSSEEI---KQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442

Query: 59  KKPIPLENPKEKRPGKRIE----REEEEEEEAL---PLDMMDEDDLQLMKDLGQRVSFLT 111
           ++ + ++    ++   ++E    R + E E AL       ++ED ++LM      ++   
Sbjct: 443 QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKL 502

Query: 112 RDLSSS------------EPVHAKKRKHERIIDKY----EKIPRTLQTAPEKELIHLLPI 155
           +D +S             E   A +R+ E ++++     E+I R  QT  E+E    L  
Sbjct: 503 QDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQE--SKLNE 560

Query: 156 KDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEH-LIERKKKLQEK 214
             KS    +  +  +  +++  ++ E + E E    +  ++ L  E++ +++R  + QE 
Sbjct: 561 AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA 620

Query: 215 KMHIAALASAILSDPENNIKKLKE------------LRSML------------------- 243
           ++    L + +L   E  + KLKE            L+  L                   
Sbjct: 621 ELE--RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKI 678

Query: 244 --MEQDPDVAVTVRKLVIVSLMELFKDITPSY---KIRPLT----EAEKSTKTRKETQKL 294
             M+ + D  +T +  +I+ + +L KD+  S    K   +T    E +K  +  ++ +K 
Sbjct: 679 ETMQFEKDNLITKQNQLILEISKL-KDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE 737

Query: 295 REFEEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALP 354
           +   E  V + +   E LE+ +K+ K+  L++     L+A   + +   K+L ++L    
Sbjct: 738 KGTLEQEVQELQLKTELLEKQMKE-KENDLQE-KFAQLEAENSILKDEKKTLEDMLKIHT 795

Query: 355 HFNFHNNIIVL--------------IVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLG 400
             +    +I L               + ++ + ++ + + C +  +++ KQ         
Sbjct: 796 PVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQ--------- 846

Query: 401 VIKVISGFVKGRNYEVR-PEMLKTFLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKSLS 458
             +    F + +N+EV   E+ + + CL    ++VK D ED +K K+ + +K K K+L+
Sbjct: 847 --RNTFSFAE-KNFEVNYQELQEEYACL----LKVKDDLED-SKNKQELEYKSKLKALN 897



 Score = 33.5 bits (75), Expect = 0.80
 Identities = 70/330 (21%), Positives = 136/330 (41%), Gaps = 45/330 (13%)

Query: 24   LENKLKNKQFKQQSTLKKYRKEQRKLR----QAVKDAVSKKPIPLENPKE-KRPGKRIER 78
            LE +++ +  + Q+ ++  +K  R+      QA+   ++ + I L+  +E ++P + +  
Sbjct: 3064 LEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLE 3123

Query: 79   EEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIP 138
               +++++  L+M  E  L  MKD   R + L   LSS + V A+  K E    K E   
Sbjct: 3124 YNIQQKQSQMLEMQVE--LSSMKD---RATELQEQLSSEKMVVAEL-KSELAQTKLEL-- 3175

Query: 139  RTLQTAPEKELIHL----LPIKDKSGIIPQTREKPVTDSNK------------------D 176
             T   A  K L  L    L +KDK+  +    +   ++  K                  +
Sbjct: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235

Query: 177  EEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKL 236
            E D+EE  +L+  +     + L +   L ++K+ L E +  I   +  +L D + + ++ 
Sbjct: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIE--SQRMLYDAQLSEEQG 3293

Query: 237  KELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLRE 296
            + L   ++ +   V +      +    EL   +  S           S    KE QK  E
Sbjct: 3294 RNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLE 3353

Query: 297  FEEGLVSQY-----KFYLENL---EQMVKD 318
             +   + +      K+ L++L   +QM KD
Sbjct: 3354 EKHSRIVELLNETEKYKLDSLQTRQQMEKD 3383



 Score = 31.6 bits (70), Expect = 3.0
 Identities = 106/503 (21%), Positives = 206/503 (40%), Gaps = 77/503 (15%)

Query: 51   QAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEA---LPLDMMDEDDLQLMKDLGQRV 107
            QA +DA+ +K   + N +E+    R E E + EE     + L++  ++    +++L Q  
Sbjct: 2192 QAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQEN 2251

Query: 108  SFLTRDLS------------SSEPVHAKKRKHERIIDKYE-----------KIPRTLQTA 144
                 D+             S++  H    K  +II + E           K+ + L+  
Sbjct: 2252 KLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT 2311

Query: 145  PEKELIHLLPIKDKSGIIPQTR---EKPVTDSNKDEEDQEEERELEEEIIEDPIQEL--- 198
             + ++I     ++K+ +I       E  ++D    + ++EEE E   E+IE   QEL   
Sbjct: 2312 TDNKVI-----EEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2366

Query: 199  ----TIEEH-LIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVT 253
                ++  H L E    L+ +   + A   A+    E   +++  ++++L E +  +   
Sbjct: 2367 GQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQL 2426

Query: 254  VRKLVIV----SLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQ--YKF 307
             ++L  +      +E  + I P   +    +     K   E     +  + L +Q  +K 
Sbjct: 2427 TQELFSLKRERESVEKIQSI-PENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKS 2485

Query: 308  YLENLEQMVKDWKQRKLKKSNVVSLK------AYKGLAEVAVKSLCELLVALPHFNFHNN 361
            + EN +  + + + R L+  + VS K       YK + ++  +   E             
Sbjct: 2486 FEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFET-------EMLQK 2538

Query: 362  IIVLIVPLMND--MSKLISEMCCEAVKKL--FKQDKLGQASLGVIKVISGFVKGRNYEVR 417
             IV +  ++ +   + L+S++  EAV++   F QD    +S      I    + R  E+ 
Sbjct: 2539 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELG 2598

Query: 418  PEMLKTFLCLRIKEVE---VKKDTEDINKPKKF----MTFKEKRKSLSRMQRKWKKAEEK 470
             ++  + L LRI E+E   V+  T  I + ++         EK K L  +Q K  +  EK
Sbjct: 2599 SDI--SALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQ-KLLEGNEK 2655

Query: 471  LERELREAEASESTEKKLKLHTE 493
             +RE +E + S    + LK  TE
Sbjct: 2656 KQRE-KEKKRSPQDVEVLKTTTE 2677


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 83/414 (20%), Positives = 176/414 (42%), Gaps = 52/414 (12%)

Query: 111 TRDLSSSEPVHAKKR--KHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREK 168
           T   ++++ + AK++   H++ +++ + +    Q   E   + +  +++K  +    ++K
Sbjct: 255 THSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDK 314

Query: 169 PVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSD 228
            V +SNK EE QE+E  +EE           +   +IE +KK  E K  +      +   
Sbjct: 315 KVENSNK-EEIQEKETIIEE-----------LNTKIIEEEKKTLELKDKLTTADKLLGEL 362

Query: 229 PENNIKKLKELRSMLME------QDPDVAVTVRKLV-IVSLMELFKDITPSYKIRPLTEA 281
            E  ++K +E+++M +E      ++   +  +++L+  V  ++        ++   +   
Sbjct: 363 QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 422

Query: 282 EKSTKTRKET----------QKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLKK-SNVV 330
           E+ T+ + E           Q++ + ++ L+ Q+   +E ++   K   +  L+  SN+ 
Sbjct: 423 EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT 482

Query: 331 SLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDMSKLISEMCC------EA 384
             +    L  VA+    EL + L   N           L  ++  ++ E C       + 
Sbjct: 483 VNEDQIKLMNVAIN---ELNIKLQDTNSQKE------KLKEELGLILEEKCALQRQLEDL 533

Query: 385 VKKL-FKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRI---KEVEVKKDTED 440
           V++L F ++++ +A   + +  S   +        E LK  +       KE+E+K + E 
Sbjct: 534 VEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEV 593

Query: 441 IN-KPKKFMTFKEKRKSLSRMQRKWKKAEEKLERELREAEASESTEKKLKLHTE 493
            N K K  M  KEK   L RM    +   E+L  +L  +   E ++ K  L  E
Sbjct: 594 TNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 80/427 (18%), Positives = 173/427 (40%), Gaps = 56/427 (13%)

Query: 80   EEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPV----HAKKRKHERIIDKYE 135
            E   E +  L+       +LM++  ++    T  L   E +    H + R  E++  +  
Sbjct: 1859 EAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELS 1918

Query: 136  KIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEE--EIIED 193
            K    +    +++ +    I++K+ II +  ++ +  SN+ +E + E+++++E  E++  
Sbjct: 1919 KAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSR 1978

Query: 194  PIQEL-----TIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDP 248
              + +      +E+ L++  +KL ++K+ +   A  +  D +  +K L          + 
Sbjct: 1979 QKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKAL----------EI 2028

Query: 249  DVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFY 308
            DV   V + + +                   E EK+T+     Q+ +  E+ L    KF 
Sbjct: 2029 DVEEQVSRFIEL-------------------EQEKNTELMDLRQQNQALEKQLEKMRKFL 2069

Query: 309  LENL--EQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLI 366
             E     +  +D  Q++++K     LK       ++     E+     H     +    +
Sbjct: 2070 DEQAIDREHERDVFQQEIQKLE-QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL 2128

Query: 367  VPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLC 426
            +     + + I E   E  K  F+  +L QA L   +   G V     E +PE+      
Sbjct: 2129 LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAV-----EAKPEL------ 2177

Query: 427  LRIKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERELREAEASESTEK 486
                EV+++ + + I++ +K +T  E++    R + + K  E +      E +  EST +
Sbjct: 2178 --SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTR 2235

Query: 487  KLKLHTE 493
              +L  E
Sbjct: 2236 LQELEQE 2242



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 74/359 (20%), Positives = 155/359 (43%), Gaps = 51/359 (14%)

Query: 7    KKQIPSFRKLIKTSKVKLENK---LKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIP 63
            ++QI   R+L+   K  ++ +   ++ +  ++   L K + E +   + V+D + K+   
Sbjct: 1966 QQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKA 2025

Query: 64   LENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAK 123
            LE   E++  + IE E+E+  E + L   ++    L K L +   FL           A 
Sbjct: 2026 LEIDVEEQVSRFIELEQEKNTELMDLRQQNQ---ALEKQLEKMRKFLDE--------QAI 2074

Query: 124  KRKHERII--DKYEKIPRTLQTAPEKELI-------------HLLPIKDKSGIIPQTREK 168
             R+HER +   + +K+ + L+  P  + I             HL    DK   +  ++E+
Sbjct: 2075 DREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ 2134

Query: 169  PVTDSNKDEEDQEE----ERELEEEIIEDPIQ---------ELTIEEHLIERKKKLQEKK 215
               D  +  E+ E+     RELE+ ++ +  +         EL++E  L   +  +  K+
Sbjct: 2135 LQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKE 2194

Query: 216  MHIAALASAI---LSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPS 272
              I  L   +     + EN  +++++L   L  Q  +    +++L   +  +LFKD    
Sbjct: 2195 KEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQEN--KLFKD--DM 2250

Query: 273  YKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENL-EQMVKDWKQRKLKKSNVV 330
             K+    +   +  T+ +     +F + ++ + +  ++ L EQ+ K  +Q K+   N V
Sbjct: 2251 EKLGLAIKESDAMSTQDQHVLFGKFAQ-IIQEKEVEIDQLNEQVTKLQQQLKITTDNKV 2308



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 72/341 (21%), Positives = 148/341 (43%), Gaps = 55/341 (16%)

Query: 6   NKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLE 65
           +++QI   R+ I   + KL     N+  K  ST++  + E       V  + S+K + L+
Sbjct: 540 SREQIQRARQTIAEQESKL-----NEAHKSLSTVEDLKAE------IVSASESRKELELK 588

Query: 66  NPKEKRPGKRIEREEEEEEEALPLDMMDEDD--------LQLMKDLGQRVSFLTRDLSSS 117
           +  E    K I+ E  E+E+   LD M E           QL+    + +S L  DL   
Sbjct: 589 HEAEVTNYK-IKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647

Query: 118 EPVHAKKRKHERIIDKYEKIP----------RTLQ-------TAPEKELIHLLPIKDKSG 160
             ++ +K K    I   ++I            T+Q       T   + ++ +  +KD   
Sbjct: 648 HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ 707

Query: 161 IIPQTREKPVT----DSNKDEE----DQEEERELEEEIIEDPIQELTIEEHLIERKKKLQ 212
            +  ++ + +T    +  K+ E    +++E+  LE+E+ E  ++   +E+ + E++  LQ
Sbjct: 708 SLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQ 767

Query: 213 EKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPS 272
           EK   + A  ++IL D +  ++ + ++ + + +++       R + + S+    KD    
Sbjct: 768 EKFAQLEA-ENSILKDEKKTLEDMLKIHTPVSQEE-------RLIFLDSIKSKSKDSVWE 819

Query: 273 YKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLE 313
            +I  L E  +  K  ++  +L E  E   + + F  +N E
Sbjct: 820 KEIEILIEENEDLK--QQCIQLNEEIEKQRNTFSFAEKNFE 858



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 105/539 (19%), Positives = 230/539 (42%), Gaps = 109/539 (20%)

Query: 2   KARRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQ---AVKDAVS 58
           K R++ ++I   ++L+ T +   +   K+ QF+     +  ++ QRKL Q    + +   
Sbjct: 386 KERQSSEEI---KQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442

Query: 59  KKPIPLENPKEKRPGKRIE----REEEEEEEAL---PLDMMDEDDLQLMKDLGQRVSFLT 111
           ++ + ++    ++   ++E    R + E E AL       ++ED ++LM      ++   
Sbjct: 443 QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKL 502

Query: 112 RDLSSS------------EPVHAKKRKHERIIDKY----EKIPRTLQTAPEKELIHLLPI 155
           +D +S             E   A +R+ E ++++     E+I R  QT  E+E    L  
Sbjct: 503 QDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQE--SKLNE 560

Query: 156 KDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEH-LIERKKKLQEK 214
             KS    +  +  +  +++  ++ E + E E    +  ++ L  E++ +++R  + QE 
Sbjct: 561 AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA 620

Query: 215 KMHIAALASAILSDPENNIKKLKE------------LRSML------------------- 243
           ++    L + +L   E  + KLKE            L+  L                   
Sbjct: 621 ELE--RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKI 678

Query: 244 --MEQDPDVAVTVRKLVIVSLMELFKDITPSY---KIRPLT----EAEKSTKTRKETQKL 294
             M+ + D  +T +  +I+ + +L KD+  S    K   +T    E +K  +  ++ +K 
Sbjct: 679 ETMQFEKDNLITKQNQLILEISKL-KDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE 737

Query: 295 REFEEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALP 354
           +   E  V + +   E LE+ +K+ K+  L++     L+A   + +   K+L ++L    
Sbjct: 738 KGTLEQEVQELQLKTELLEKQMKE-KENDLQE-KFAQLEAENSILKDEKKTLEDMLKIHT 795

Query: 355 HFNFHNNIIVL--------------IVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLG 400
             +    +I L               + ++ + ++ + + C +  +++ KQ         
Sbjct: 796 PVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQ--------- 846

Query: 401 VIKVISGFVKGRNYEVR-PEMLKTFLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKSLS 458
             +    F + +N+EV   E+ + + CL    ++VK D ED +K K+ + +K K K+L+
Sbjct: 847 --RNTFSFAE-KNFEVNYQELQEEYACL----LKVKDDLED-SKNKQELEYKSKLKALN 897



 Score = 33.5 bits (75), Expect = 0.80
 Identities = 70/330 (21%), Positives = 136/330 (41%), Gaps = 45/330 (13%)

Query: 24   LENKLKNKQFKQQSTLKKYRKEQRKLR----QAVKDAVSKKPIPLENPKE-KRPGKRIER 78
            LE +++ +  + Q+ ++  +K  R+      QA+   ++ + I L+  +E ++P + +  
Sbjct: 3056 LEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLE 3115

Query: 79   EEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIP 138
               +++++  L+M  E  L  MKD   R + L   LSS + V A+  K E    K E   
Sbjct: 3116 YNIQQKQSQMLEMQVE--LSSMKD---RATELQEQLSSEKMVVAEL-KSELAQTKLEL-- 3167

Query: 139  RTLQTAPEKELIHL----LPIKDKSGIIPQTREKPVTDSNK------------------D 176
             T   A  K L  L    L +KDK+  +    +   ++  K                  +
Sbjct: 3168 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3227

Query: 177  EEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKL 236
            E D+EE  +L+  +     + L +   L ++K+ L E +  I   +  +L D + + ++ 
Sbjct: 3228 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIE--SQRMLYDAQLSEEQG 3285

Query: 237  KELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLRE 296
            + L   ++ +   V +      +    EL   +  S           S    KE QK  E
Sbjct: 3286 RNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLE 3345

Query: 297  FEEGLVSQY-----KFYLENL---EQMVKD 318
             +   + +      K+ L++L   +QM KD
Sbjct: 3346 EKHSRIVELLNETEKYKLDSLQTRQQMEKD 3375



 Score = 31.6 bits (70), Expect = 3.0
 Identities = 106/503 (21%), Positives = 206/503 (40%), Gaps = 77/503 (15%)

Query: 51   QAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEA---LPLDMMDEDDLQLMKDLGQRV 107
            QA +DA+ +K   + N +E+    R E E + EE     + L++  ++    +++L Q  
Sbjct: 2184 QAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQEN 2243

Query: 108  SFLTRDLS------------SSEPVHAKKRKHERIIDKYE-----------KIPRTLQTA 144
                 D+             S++  H    K  +II + E           K+ + L+  
Sbjct: 2244 KLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT 2303

Query: 145  PEKELIHLLPIKDKSGIIPQTR---EKPVTDSNKDEEDQEEERELEEEIIEDPIQEL--- 198
             + ++I     ++K+ +I       E  ++D    + ++EEE E   E+IE   QEL   
Sbjct: 2304 TDNKVI-----EEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2358

Query: 199  ----TIEEH-LIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVT 253
                ++  H L E    L+ +   + A   A+    E   +++  ++++L E +  +   
Sbjct: 2359 GQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQL 2418

Query: 254  VRKLVIV----SLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQ--YKF 307
             ++L  +      +E  + I P   +    +     K   E     +  + L +Q  +K 
Sbjct: 2419 TQELFSLKRERESVEKIQSI-PENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKS 2477

Query: 308  YLENLEQMVKDWKQRKLKKSNVVSLK------AYKGLAEVAVKSLCELLVALPHFNFHNN 361
            + EN +  + + + R L+  + VS K       YK + ++  +   E             
Sbjct: 2478 FEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFET-------EMLQK 2530

Query: 362  IIVLIVPLMND--MSKLISEMCCEAVKKL--FKQDKLGQASLGVIKVISGFVKGRNYEVR 417
             IV +  ++ +   + L+S++  EAV++   F QD    +S      I    + R  E+ 
Sbjct: 2531 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELG 2590

Query: 418  PEMLKTFLCLRIKEVE---VKKDTEDINKPKKF----MTFKEKRKSLSRMQRKWKKAEEK 470
             ++  + L LRI E+E   V+  T  I + ++         EK K L  +Q K  +  EK
Sbjct: 2591 SDI--SALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQ-KLLEGNEK 2647

Query: 471  LERELREAEASESTEKKLKLHTE 493
             +RE +E + S    + LK  TE
Sbjct: 2648 KQRE-KEKKRSPQDVEVLKTTTE 2669


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,685,289
Number of Sequences: 37866
Number of extensions: 1368083
Number of successful extensions: 18282
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 683
Number of HSP's that attempted gapping in prelim test: 11906
Number of HSP's gapped (non-prelim): 4669
length of query: 800
length of database: 18,247,518
effective HSP length: 110
effective length of query: 690
effective length of database: 14,082,258
effective search space: 9716758020
effective search space used: 9716758020
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.