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Search of human proteins with 205277425
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|205277425 immunoglobulin superfamily, member 9 isoform a
[Homo sapiens]
(1179 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|205277425 immunoglobulin superfamily, member 9 isoform a [Hom... 2412 0.0
gi|205277423 immunoglobulin superfamily, member 9 isoform b [Hom... 2365 0.0
gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens] 760 0.0
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 145 2e-34
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 145 2e-34
gi|118572606 hemicentin 1 [Homo sapiens] 142 2e-33
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 130 6e-30
gi|222352127 sidekick 2 [Homo sapiens] 127 5e-29
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 127 5e-29
gi|119220552 sidekick 1 [Homo sapiens] 126 1e-28
gi|109150416 peroxidasin [Homo sapiens] 126 1e-28
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 125 2e-28
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 125 2e-28
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 125 3e-28
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 124 4e-28
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 124 4e-28
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 124 4e-28
gi|19743806 roundabout 1 isoform b [Homo sapiens] 124 5e-28
gi|4506569 roundabout 1 isoform a [Homo sapiens] 124 5e-28
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [... 124 7e-28
gi|157311649 neogenin homolog 1 [Homo sapiens] 124 7e-28
gi|83281200 protogenin [Homo sapiens] 123 9e-28
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 122 2e-27
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 121 3e-27
gi|224994173 roundabout 1 isoform d [Homo sapiens] 119 2e-26
gi|224994171 roundabout 1 isoform c [Homo sapiens] 119 2e-26
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 119 2e-26
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 119 2e-26
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 118 3e-26
gi|126517478 peroxidasin homolog-like [Homo sapiens] 115 3e-25
>gi|205277425 immunoglobulin superfamily, member 9 isoform a [Homo
sapiens]
Length = 1179
Score = 2412 bits (6250), Expect = 0.0
Identities = 1179/1179 (100%), Positives = 1179/1179 (100%)
Query: 1 MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60
MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF
Sbjct: 1 MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60
Query: 61 GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120
GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED
Sbjct: 61 GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120
Query: 121 DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180
DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG
Sbjct: 121 DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180
Query: 181 QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240
QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA
Sbjct: 181 QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240
Query: 241 SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300
SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT
Sbjct: 241 SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300
Query: 301 CVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKD 360
CVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKD
Sbjct: 301 CVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKD 360
Query: 361 GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF 420
GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF
Sbjct: 361 GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF 420
Query: 421 IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA 480
IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA
Sbjct: 421 IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA 480
Query: 481 HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFS 540
HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFS
Sbjct: 481 HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFS 540
Query: 541 VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL 600
VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL
Sbjct: 541 VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL 600
Query: 601 SAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEG 660
SAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEG
Sbjct: 601 SAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEG 660
Query: 661 RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV 720
RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV
Sbjct: 661 RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV 720
Query: 721 YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLI 780
YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLI
Sbjct: 721 YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLI 780
Query: 781 FSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPL 840
FSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPL
Sbjct: 781 FSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPL 840
Query: 841 PLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCI 900
PLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCI
Sbjct: 841 PLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCI 900
Query: 901 EDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR 960
EDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR
Sbjct: 901 EDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR 960
Query: 961 CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS 1020
CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS
Sbjct: 961 CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS 1020
Query: 1021 LTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNT 1080
LTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNT
Sbjct: 1021 LTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNT 1080
Query: 1081 SVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEA 1140
SVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEA
Sbjct: 1081 SVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEA 1140
Query: 1141 RCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL 1179
RCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL
Sbjct: 1141 RCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL 1179
>gi|205277423 immunoglobulin superfamily, member 9 isoform b [Homo
sapiens]
Length = 1163
Score = 2365 bits (6128), Expect = 0.0
Identities = 1162/1179 (98%), Positives = 1162/1179 (98%), Gaps = 16/1179 (1%)
Query: 1 MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60
MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF
Sbjct: 1 MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60
Query: 61 GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120
GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED
Sbjct: 61 GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120
Query: 121 DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180
DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG
Sbjct: 121 DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180
Query: 181 QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240
QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA
Sbjct: 181 QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240
Query: 241 SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300
SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT
Sbjct: 241 SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300
Query: 301 CVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKD 360
CVPSNGLLHPPSASAYLTVL MPGVIRCPVRANPPLLFVSWTKD
Sbjct: 301 CVPSNGLLHPPSASAYLTVLC----------------MPGVIRCPVRANPPLLFVSWTKD 344
Query: 361 GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF 420
GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF
Sbjct: 345 GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF 404
Query: 421 IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA 480
IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA
Sbjct: 405 IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA 464
Query: 481 HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFS 540
HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFS
Sbjct: 465 HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFS 524
Query: 541 VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL 600
VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL
Sbjct: 525 VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL 584
Query: 601 SAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEG 660
SAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEG
Sbjct: 585 SAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEG 644
Query: 661 RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV 720
RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV
Sbjct: 645 RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV 704
Query: 721 YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLI 780
YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLI
Sbjct: 705 YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLI 764
Query: 781 FSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPL 840
FSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPL
Sbjct: 765 FSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPL 824
Query: 841 PLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCI 900
PLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCI
Sbjct: 825 PLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCI 884
Query: 901 EDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR 960
EDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR
Sbjct: 885 EDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR 944
Query: 961 CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS 1020
CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS
Sbjct: 945 CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS 1004
Query: 1021 LTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNT 1080
LTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNT
Sbjct: 1005 LTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNT 1064
Query: 1081 SVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEA 1140
SVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEA
Sbjct: 1065 SVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEA 1124
Query: 1141 RCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL 1179
RCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL
Sbjct: 1125 RCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL 1163
>gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]
Length = 1349
Score = 760 bits (1963), Expect = 0.0
Identities = 443/1026 (43%), Positives = 578/1026 (56%), Gaps = 69/1026 (6%)
Query: 1 MVWCLGLAVLSLVISQGADGRG----KPEVVSVVGRAGESVVLGCDLLPPA-GRPPLHVI 55
M+W + + S++ ++G G + E V RAGESVVL CD++ P G+PP +V+
Sbjct: 1 MIWYVATFIASVIGTRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVV 60
Query: 56 EWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQ 115
EW +FG +PIFI+FG Y P +DP+Y GR L ASL++E +R EDQGWYEC+V LDQ
Sbjct: 61 EWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQ 120
Query: 116 HIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGK 175
D F NGSWVHLT+N+PP F ETPP +E +E +T+ C A G+P P VTW G
Sbjct: 121 QY--DTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGT 178
Query: 176 DLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKN 235
LG G+ QV +G+L + V R G YTC+A S +G A H T LLV GPP IV PP+N
Sbjct: 179 LLG-ASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPEN 237
Query: 236 STVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDD 295
TVN SQD L C AEAYP NLTY+W+ + NV+ + L+ RVRIL+DG+L + +P+D
Sbjct: 238 ITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPED 297
Query: 296 AGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFV 355
+G YTCVPSN L PSASAYLTV YPA+V MPP +P+G+ G IRCPV A PP V
Sbjct: 298 SGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVV 357
Query: 356 SWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLK 415
W KDG+ LQ++K GW+ +GS+ I E+ALG Y+C PYN+LGT G S R++LK
Sbjct: 358 KWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLK 417
Query: 416 APPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRP 475
PP F P EY QE GRELLIPC+A GDP PV++W KVG+ + + + SL R
Sbjct: 418 DPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRA 477
Query: 476 LTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGY 535
L+KE HG WEC A+N V + ST++ V+GTSPH +V V ANVSWEPG+DGGY
Sbjct: 478 LSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGY 537
Query: 536 LQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPF 595
Q FSVW KR HDW+SL VP G + LLV L+P T YQFSVLAQNKLG+ F
Sbjct: 538 EQTFSVW----MKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAF 593
Query: 596 SEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDG 655
SE+V P T P + T PPR L+A RT +GVLL W PP +D
Sbjct: 594 SEVVTVNTLAFPITTPEPLVLVT-------PPRCLIANRTQQGVLLSWLPPANHSFPIDR 646
Query: 656 YVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVST 715
Y++E R ++ WE+LD + GTE E L +D YEFR++A +S+PSN A VS+
Sbjct: 647 YIMEFRV-AERWELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSS 705
Query: 716 SGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQ 775
+ +++P L +PVLAG+V +CFL A+L S LA C +N++R + +RK+
Sbjct: 706 T--DIFPQPDLTEDGLARPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKK--- 760
Query: 776 DPPLIFSPTGKS-AAPSALGSGSPDSVAKLKL-------QGSPVP------------SLR 815
DPPL + KS +P + G SP+S+ L+ QG P SL
Sbjct: 761 DPPLSITHCRKSLESPLSSGKVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLY 820
Query: 816 QSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRT 875
+ + S + P+E I RGPDGRFVM P P +S R + P
Sbjct: 821 KKTKRAISSKKYSVAKAEAEAEATTPIELISRGPDGRFVMDPAEMEPSLKSRRIEGFPFA 880
Query: 876 PAQRLARSFDCSSSSPSGAPQPLCI----EDISPVA-------PPPA----APPSPLPGP 920
+ F S P + ++P++ PPPA P L GP
Sbjct: 881 EETDMYPEFRQSDEENEDPLVPTSVAALKSQLTPLSSSQESYLPPPAYSPRFQPRGLEGP 940
Query: 921 GPLLQYLSL------PFFREMNVDGDWPPLEEPSPA---APPDYMDTRRCPTSSFLRSPE 971
G L L P R + + L SP PP Y+ P SS + SP
Sbjct: 941 GGLEGRLQATGQARPPAPRPFHHGQYYGYLSSSSPGEVEPPPFYVPEVGSPLSSVMSSPP 1000
Query: 972 TPPVSP 977
P P
Sbjct: 1001 LPTEGP 1006
Score = 35.4 bits (80), Expect = 0.32
Identities = 81/314 (25%), Positives = 105/314 (33%), Gaps = 56/314 (17%)
Query: 793 LGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSP--HPDPPSSRGP------LPLEP 844
L S SP V V S S++ P T P HP P G LPL
Sbjct: 970 LSSSSPGEVEPPPFYVPEVGSPLSSVMSSPPLPTEGPFGHPTIPEENGENASNSTLPLTQ 1029
Query: 845 ICRG-----PDGR--FVMG----PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSS-PS 892
G P GR F G P + P + + E P L R +S P+
Sbjct: 1030 TPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLPPCDVPESLQPKAGLPRGLPPTSLQVPA 1089
Query: 893 GAPQPLCIE------DISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEE 946
P L +E SP P APP+ P+ +S R + P L
Sbjct: 1090 AYPGILSLEAPKGWAGKSPGRGPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPVLPY 1149
Query: 947 PSPAAPPDY-------MDTRRCPTSSFLRSPETPPVSPRE------SLPGAVVGAGATAE 993
P PA P + +DTR + P SPR+ SL V+ +
Sbjct: 1150 PEPAEPGAHGGPSTFGLDTR------WYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSP 1203
Query: 994 PPYTALADWT------LRERLLPGLLPAAPRGSLTSQ-----SSGRGSASFLRPPSTAPS 1042
+ L+ T R R PGLL A +T Q S R S PS +
Sbjct: 1204 LTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSTGSPSQSSR 1263
Query: 1043 AGGSYLSPAPGDTS 1056
+G PA G T+
Sbjct: 1264 SGSPSYRPAMGFTT 1277
Score = 33.1 bits (74), Expect = 1.6
Identities = 77/307 (25%), Positives = 107/307 (34%), Gaps = 50/307 (16%)
Query: 615 LPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPE--LVPKRLDGYV-LEGRQGSQG----- 666
LPP ++P L P GL PRG+ PP VP G + LE +G G
Sbjct: 1061 LPPCDVPESLQPKAGL-----PRGL-----PPTSLQVPAAYPGILSLEAPKGWAGKSPGR 1110
Query: 667 WEVLDPAVAGTETELLVP----GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYP 722
V P A + + P G ++ + ++P ST GL+
Sbjct: 1111 GPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPVLPYPEPAEPGAHGGPSTFGLD--- 1167
Query: 723 SRTQLPGLLPQPVLAGVVGGVCFLGVAVL----VSILAGCLLNRRRAARRRRKRLRQDPP 778
+R P P+P L VL +S L L+ R + R R P
Sbjct: 1168 TRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSPLTQSPLSSRTGSPELAARARPRPG 1227
Query: 779 LIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTP--------SPH 830
L+ + A S + P +V+ + S QS G P+ P + +
Sbjct: 1228 LL-----QQAEMSEITLQPPAAVSFSRKSTPSTGSPSQSSRSGSPSYRPAMGFTTLATGY 1282
Query: 831 PDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSS 890
P PP GP P P D V G T + R+G E P TP L S
Sbjct: 1283 PSPPP--GPAPAGP----GDSLDVFGQTPS--PRRTGEELLRPETPPPTLPTSGKLQRDR 1334
Query: 891 PSGAPQP 897
P+ A P
Sbjct: 1335 PAPATSP 1341
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 145 bits (366), Expect = 2e-34
Identities = 170/660 (25%), Positives = 254/660 (38%), Gaps = 83/660 (12%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F++ P V+ V EP L C RG P P + WK + + ++ ++ G L I
Sbjct: 151 FRQNPTDVV-VAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNT 209
Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G+YTC ++ G + +L V P + P N V + V C + P
Sbjct: 210 RKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ 269
Query: 256 NLTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSA 313
T W +D+ ++ PR R I D +LR+ T D G Y C+ N + A
Sbjct: 270 P-TVRWKKDDADL-------PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRV-GKMEA 320
Query: 314 SAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGW 372
SA LTV P Q P + + G C + NP P +F W K+G L FP
Sbjct: 321 SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVF--WQKEGSQNLL--FPNQ 376
Query: 373 SQ--------GTEGSLIIALGNEDALGEYSC---TPYNSLGTAGPSPVTRVLLKAPPAFI 421
Q G L I G Y C T S+ VT VL PP I
Sbjct: 377 PQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPII 436
Query: 422 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG---RGLQGQAQVDSNSSLILRPLTK 478
+ V L+ C A GDP PV+SW K G G +A + +L ++ L
Sbjct: 437 LQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 496
Query: 479 EAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALP-------------KGANV 525
G + C A+++ + S + V + + N + LP +
Sbjct: 497 SDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL 556
Query: 526 SWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVL 585
SW+PG G + + + + W ++A V V GL+P+T Y F V
Sbjct: 557 SWQPGTPGTLPASAYI----IEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVR 612
Query: 586 AQNKLG---SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVR-------T 635
A N G P S+ V + +P A G+ ++ L G V VR T
Sbjct: 613 AINPQGLSDPSPMSDPVRTQ----DISPPAQGVDHRQVQKEL----GDVLVRLHNPVVLT 664
Query: 636 PRGVLLHWDPPELVPKRLDGYVL-----EGRQGSQGWEVLDPAVAGTETELLVPGLIKDV 690
P V + W + P+ + GY + G Q + W+ LD V TE ++ L K V
Sbjct: 665 PTTVQVTW-TVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVP-TERSAVLVNLKKGV 722
Query: 691 LYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAV 750
YE ++ + F S + V T+ + P PQ V VG ++V
Sbjct: 723 TYEIKVRPYFNEFQGMDSESKTVRTT--------EEAPSAPPQSVTVLTVGSYNSTSISV 774
Score = 97.8 bits (242), Expect = 5e-20
Identities = 140/608 (23%), Positives = 221/608 (36%), Gaps = 64/608 (10%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
PP+ E P V+ V + EP TL C A G P P + W G+ + + ++ + +G
Sbjct: 46 PPRIVEHPSDVI-VSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 104
Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
+L R+ G G Y C A + G A +A+ + L P + V A +
Sbjct: 105 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGE 164
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
L C T W +D + I + R+ I G L + T+ DAG YTCV
Sbjct: 165 PAILECQPPRGHPEPTIYWKKDKV---RIDDKEERISIR-GGKLMISNTRKSDAGMYTCV 220
Query: 303 PSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGK 362
+N + S A LTV P + RC V+ +P V W KD
Sbjct: 221 GTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPT-VRWKKDDA 279
Query: 363 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIE 422
L ++ + +L I G Y C N +G S V +APP F+
Sbjct: 280 DLPRGRY---DIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RAPPQFVV 334
Query: 423 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG----------RGLQGQAQVDSNSSLI 472
RP+++ + GR + PC +G+P P V W K G + + V L
Sbjct: 335 RPRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT 393
Query: 473 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFD 532
+ + + G++ C A + + V + + L AN + D
Sbjct: 394 ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDV---LTDRPPPIILQGPANQTL--AVD 448
Query: 533 GGYLQRFSVWYTPLAKRPDRMHHDWVS----------LAVPVGAAHLLVPGLQPHTQYQF 582
G L + PL W+ A L + L+ +
Sbjct: 449 GTALLKCKATGDPLPV------ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTY 502
Query: 583 SVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLH 642
+ +A + G +S ++ G + +++P P S P+ V T V L
Sbjct: 503 TCVATSSSGETSWSAVLDVTESG---ATISKNYDLSDLPGPPSKPQ--VTDVTKNSVTLS 557
Query: 643 WDPPELVPKRLDGYVLE--GRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFA 700
W P Y++E + S W+ + V T V GL + +Y F + A
Sbjct: 558 WQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHV--KTTLYTVRGLRPNTIYLFMVRAIN 615
Query: 701 GSFVSDPS 708
+SDPS
Sbjct: 616 PQGLSDPS 623
Score = 94.4 bits (233), Expect = 6e-19
Identities = 106/392 (27%), Positives = 152/392 (38%), Gaps = 36/392 (9%)
Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88
VV AGE +L C PP G P I W + RID D R+ +
Sbjct: 158 VVVAAGEPAILECQ--PPRGHPE-PTIYWKKD-------------KVRID-DKEERISI- 199
Query: 89 KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEV 148
+G L I R D G Y C + D LTV P F P + +
Sbjct: 200 RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP------AELTVFERPTFLRRPINQVVL 253
Query: 149 QELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA 208
+E E V RC +G P P V WK DL +G+ ++ + TLRI++ G Y C A
Sbjct: 254 EE-EAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIK-DDYTLRIKKTMSTDEGTYMCIA 311
Query: 209 SSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN- 267
+ G + L V PP VV P++ V + V+ C + P + + + N
Sbjct: 312 ENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNL 371
Query: 268 VFHISRLQPRVRILVD--GSLRLLATQPDDAGCYTC---VPSNGLLHPP--SASAYLTVL 320
+F QP R V G L + Q DAG Y C + +L + LT
Sbjct: 372 LFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDR 431
Query: 321 YPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 380
P + P L + +++C + PL +SW K+G + P + +G+L
Sbjct: 432 PPPIILQGPANQTLAVDGTALLKCKATGD-PLPVISWLKEGFTFP-GRDPRATIQEQGTL 489
Query: 381 IIALGNEDALGEYSCTPYNSLGTAGPSPVTRV 412
I G Y+C +S G S V V
Sbjct: 490 QIKNLRISDTGTYTCVATSSSGETSWSAVLDV 521
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 145 bits (366), Expect = 2e-34
Identities = 170/660 (25%), Positives = 254/660 (38%), Gaps = 83/660 (12%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F++ P V+ V EP L C RG P P + WK + + ++ ++ G L I
Sbjct: 135 FRQNPTDVV-VAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNT 193
Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G+YTC ++ G + +L V P + P N V + V C + P
Sbjct: 194 RKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ 253
Query: 256 NLTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSA 313
T W +D+ ++ PR R I D +LR+ T D G Y C+ N + A
Sbjct: 254 P-TVRWKKDDADL-------PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRV-GKMEA 304
Query: 314 SAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGW 372
SA LTV P Q P + + G C + NP P +F W K+G L FP
Sbjct: 305 SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVF--WQKEGSQNLL--FPNQ 360
Query: 373 SQ--------GTEGSLIIALGNEDALGEYSC---TPYNSLGTAGPSPVTRVLLKAPPAFI 421
Q G L I G Y C T S+ VT VL PP I
Sbjct: 361 PQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPII 420
Query: 422 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG---RGLQGQAQVDSNSSLILRPLTK 478
+ V L+ C A GDP PV+SW K G G +A + +L ++ L
Sbjct: 421 LQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 480
Query: 479 EAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALP-------------KGANV 525
G + C A+++ + S + V + + N + LP +
Sbjct: 481 SDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL 540
Query: 526 SWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVL 585
SW+PG G + + + + W ++A V V GL+P+T Y F V
Sbjct: 541 SWQPGTPGTLPASAYI----IEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVR 596
Query: 586 AQNKLG---SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVR-------T 635
A N G P S+ V + +P A G+ ++ L G V VR T
Sbjct: 597 AINPQGLSDPSPMSDPVRTQ----DISPPAQGVDHRQVQKEL----GDVLVRLHNPVVLT 648
Query: 636 PRGVLLHWDPPELVPKRLDGYVL-----EGRQGSQGWEVLDPAVAGTETELLVPGLIKDV 690
P V + W + P+ + GY + G Q + W+ LD V TE ++ L K V
Sbjct: 649 PTTVQVTW-TVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVP-TERSAVLVNLKKGV 706
Query: 691 LYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAV 750
YE ++ + F S + V T+ + P PQ V VG ++V
Sbjct: 707 TYEIKVRPYFNEFQGMDSESKTVRTT--------EEAPSAPPQSVTVLTVGSYNSTSISV 758
Score = 97.8 bits (242), Expect = 5e-20
Identities = 140/608 (23%), Positives = 221/608 (36%), Gaps = 64/608 (10%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
PP+ E P V+ V + EP TL C A G P P + W G+ + + ++ + +G
Sbjct: 30 PPRIVEHPSDVI-VSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 88
Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
+L R+ G G Y C A + G A +A+ + L P + V A +
Sbjct: 89 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGE 148
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
L C T W +D + I + R+ I G L + T+ DAG YTCV
Sbjct: 149 PAILECQPPRGHPEPTIYWKKDKV---RIDDKEERISIR-GGKLMISNTRKSDAGMYTCV 204
Query: 303 PSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGK 362
+N + S A LTV P + RC V+ +P V W KD
Sbjct: 205 GTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPT-VRWKKDDA 263
Query: 363 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIE 422
L ++ + +L I G Y C N +G S V +APP F+
Sbjct: 264 DLPRGRY---DIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RAPPQFVV 318
Query: 423 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG----------RGLQGQAQVDSNSSLI 472
RP+++ + GR + PC +G+P P V W K G + + V L
Sbjct: 319 RPRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT 377
Query: 473 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFD 532
+ + + G++ C A + + V + + L AN + D
Sbjct: 378 ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDV---LTDRPPPIILQGPANQTL--AVD 432
Query: 533 GGYLQRFSVWYTPLAKRPDRMHHDWVS----------LAVPVGAAHLLVPGLQPHTQYQF 582
G L + PL W+ A L + L+ +
Sbjct: 433 GTALLKCKATGDPLPV------ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTY 486
Query: 583 SVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLH 642
+ +A + G +S ++ G + +++P P S P+ V T V L
Sbjct: 487 TCVATSSSGETSWSAVLDVTESG---ATISKNYDLSDLPGPPSKPQ--VTDVTKNSVTLS 541
Query: 643 WDPPELVPKRLDGYVLE--GRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFA 700
W P Y++E + S W+ + V T V GL + +Y F + A
Sbjct: 542 WQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHV--KTTLYTVRGLRPNTIYLFMVRAIN 599
Query: 701 GSFVSDPS 708
+SDPS
Sbjct: 600 PQGLSDPS 607
Score = 94.4 bits (233), Expect = 6e-19
Identities = 106/392 (27%), Positives = 152/392 (38%), Gaps = 36/392 (9%)
Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88
VV AGE +L C PP G P I W + RID D R+ +
Sbjct: 142 VVVAAGEPAILECQ--PPRGHPE-PTIYWKKD-------------KVRID-DKEERISI- 183
Query: 89 KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEV 148
+G L I R D G Y C + D LTV P F P + +
Sbjct: 184 RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP------AELTVFERPTFLRRPINQVVL 237
Query: 149 QELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA 208
+E E V RC +G P P V WK DL +G+ ++ + TLRI++ G Y C A
Sbjct: 238 EE-EAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIK-DDYTLRIKKTMSTDEGTYMCIA 295
Query: 209 SSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN- 267
+ G + L V PP VV P++ V + V+ C + P + + + N
Sbjct: 296 ENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNL 355
Query: 268 VFHISRLQPRVRILVD--GSLRLLATQPDDAGCYTC---VPSNGLLHPP--SASAYLTVL 320
+F QP R V G L + Q DAG Y C + +L + LT
Sbjct: 356 LFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDR 415
Query: 321 YPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 380
P + P L + +++C + PL +SW K+G + P + +G+L
Sbjct: 416 PPPIILQGPANQTLAVDGTALLKCKATGD-PLPVISWLKEGFTFP-GRDPRATIQEQGTL 473
Query: 381 IIALGNEDALGEYSCTPYNSLGTAGPSPVTRV 412
I G Y+C +S G S V V
Sbjct: 474 QIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 142 bits (357), Expect = 2e-33
Identities = 136/510 (26%), Positives = 216/510 (42%), Gaps = 47/510 (9%)
Query: 20 GRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDP 79
G +P ++V+ ++ D +PP VI WLR G L +PR+
Sbjct: 3624 GTDEPRDITVLRNRQVTLECKSDAVPPP------VITWLRNGERLQA-------TPRV-- 3668
Query: 80 DYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ 139
R+ L G LQI + D Y C + + LTVN PP +
Sbjct: 3669 ----RI-LSGGRYLQINNADLGDTANYTCVASNIAGKTTREFI-------LTVNVPPNIK 3716
Query: 140 ETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVER 198
P +++ + V L C+A G P P +TW+ G L + + +NG L I+
Sbjct: 3717 GGPQSLVILLNKSTV-LECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHV 3775
Query: 199 GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLT 258
+G Y C A++ G+ L V PP I P N TV + +LAC A P +
Sbjct: 3776 TDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIP-KPS 3834
Query: 259 YSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLT 318
+W + N ++ ++ + Q R+L GSL +++ DD Y C +NG + LT
Sbjct: 3835 INW-RKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNG-AGDDKRTVDLT 3892
Query: 319 VLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG 378
V P + P + + P VI C + P + WTK+G L L + G+ + G
Sbjct: 3893 VQVPPSIADEPTDFLVTKHAPAVITC-TASGVPFPSIHWTKNGIRL-LPRGDGYRILSSG 3950
Query: 379 SLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLI 438
++ I + G Y+C N+ G+A V PP +P E + + +L+
Sbjct: 3951 AIEILATQLNHAGRYTCVARNAAGSAHRHVTLHV--HEPPVIQPQPSELHV-ILNNPILL 4007
Query: 439 PCSAQGDPPPVVSWTKVGRGL----QGQAQVDSNSSLILRPLTKEAHGHWECSASN---- 490
PC A G P P ++W K G + + A + S I R + ++A G + C A N
Sbjct: 4008 PCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDA-GTYMCVAQNPAGT 4066
Query: 491 AVARVATSTNVYVLGTSPHVVTNVSVVALP 520
A+ ++ + V + SPH+ V V P
Sbjct: 4067 ALGKIKLNVQVPPV-ISPHLKEYVIAVDKP 4095
Score = 134 bits (338), Expect = 4e-31
Identities = 107/378 (28%), Positives = 172/378 (45%), Gaps = 14/378 (3%)
Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQV 186
V L V+ PP Q P + L V P+ L C A G+P P +TW+ G ++ G+ +
Sbjct: 3980 VTLHVHEPPVIQPQP-SELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVL 4038
Query: 187 QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246
+G L+I R R +G Y C A + G+A +L V PPVI K + + ++L
Sbjct: 4039 PSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITL 4098
Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306
+C A+ P +W +D + R R+L GSL++ QP DAG YTC+ +N
Sbjct: 4099 SCEADGLPPP-DITWHKDGRAIVE----SIRQRVLSSGSLQIAFVQPGDAGHYTCMAAN- 4152
Query: 307 LLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQL 366
+ S S LTV P ++ + + ++ C V P ++W KD L
Sbjct: 4153 VAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPC-VADGIPTPAINWKKD-NVLLA 4210
Query: 367 DKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKE 426
+ ++ G LI+ + G Y+C N+ G + + + P F E P +
Sbjct: 4211 NLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGE--DTHTVSLTVHVLPTFTELPGD 4268
Query: 427 EYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ-AQVDSNSSLILRPLTKEAHGHWE 485
+ G +L + C A G P P ++WT + V+ +S L++ ++KE G +
Sbjct: 4269 VSLNK-GEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYV 4327
Query: 486 CSASNAVARVATSTNVYV 503
C+A N+V V VYV
Sbjct: 4328 CTAENSVGFVKAIGFVYV 4345
Score = 129 bits (324), Expect = 2e-29
Identities = 101/365 (27%), Positives = 168/365 (46%), Gaps = 19/365 (5%)
Query: 152 EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASST 211
+P+TL C A G P P +TW G+ + + Q + +G+L+I V+ G +G YTC A++
Sbjct: 4094 KPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANV 4153
Query: 212 EGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHI 271
GS++ +T+L V PP I + TVN + L C A+ P +W +DN+ +
Sbjct: 4154 AGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTP-AINWKKDNV---LL 4209
Query: 272 SRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPE 331
+ L + G L L +D+G YTCV +N + + LTV T +P +
Sbjct: 4210 ANLLGKYTAEPYGELILENVVLEDSGFYTCV-ANNAAGEDTHTVSLTVHVLPTFTELPGD 4268
Query: 332 TPLPIGMPGVIRCPVRANPPLLFVSWTKDGKAL--QLDKFPGWSQGTEGSLIIALGNEDA 389
L G + C PL ++WT + + D G S+ L+I +++
Sbjct: 4269 VSLNKGEQLRLSCKA-TGIPLPKLTWTFNNNIIPAHFDSVNGHSE-----LVIERVSKED 4322
Query: 390 LGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPV 449
G Y CT NS+G + V +K PP F + + +G ++ C +GDP P
Sbjct: 4323 SGTYVCTAENSVGFV--KAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPT 4380
Query: 450 VSWTKVGRGLQGQAQVD--SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTS 507
+ W + G ++ ++ N SL + E G + C A+N V S ++ + S
Sbjct: 4381 IQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTL--QS 4438
Query: 508 PHVVT 512
P ++T
Sbjct: 4439 PPIIT 4443
Score = 129 bits (323), Expect = 2e-29
Identities = 110/424 (25%), Positives = 173/424 (40%), Gaps = 25/424 (5%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
R R+ SLQI ++ D G Y C + ++ + LTV+ PP+ + T
Sbjct: 4124 RQRVLSSGSLQIAFVQPGDAGHYTCMAANVAG-------SSSTSTKLTVHVPPRIRSTE- 4175
Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQN-GTLRIRRVERGSSG 202
V E L CVA G P P + WK L G+ + G L + V SG
Sbjct: 4176 GHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSG 4235
Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWF 262
YTC A++ G TH L V P P + ++N + + L+C A P F
Sbjct: 4236 FYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTF 4295
Query: 263 QDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYP 322
+NI H + ++++ +D+G Y C N + + P
Sbjct: 4296 NNNIIPAHFDSVNGHSELVIE------RVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP 4349
Query: 323 AQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 382
P P+G ++ C V+ +P + W + G +++ Q GSL I
Sbjct: 4350 VFKGDYPSNWIEPLGGNAILNCEVKGDPTPT-IQWNRKGVDIEISH--RIRQLGNGSLAI 4406
Query: 383 -ALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCS 441
NEDA G+Y+C N G S + L++PP P E G ++++ C
Sbjct: 4407 YGTVNEDA-GDYTCVATNEAGVVERS--MSLTLQSPPIITLEPVETVIN-AGGKIILNCQ 4462
Query: 442 AQGDPPPVVSWTKVGRGLQGQAQVD--SNSSLILRPLTKEAHGHWECSASNAVARVATST 499
A G+P P ++W++ G + +V+ SN+SL + KE +EC A N + V
Sbjct: 4463 ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRV 4522
Query: 500 NVYV 503
V V
Sbjct: 4523 PVIV 4526
Score = 115 bits (289), Expect = 2e-25
Identities = 112/447 (25%), Positives = 186/447 (41%), Gaps = 33/447 (7%)
Query: 92 SLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANG-SWVHLTVNSPPQFQETPPAVLEVQE 150
+L I + + D+G+YEC I G + V+ PP + P V V
Sbjct: 483 NLDIAKVTLSDEGFYEC--------IAVSSAGTGRAQTFFDVSEPPPVIQVPNNVT-VTP 533
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKD--LGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA 208
E L C+ + ++TW+ +D L + + N +L ++ V+ +G Y C
Sbjct: 534 GERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMV 593
Query: 209 SSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV 268
SS GS+ + L V PP + V PKN + +VS+ C A YP +W +++ +
Sbjct: 594 SSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYP-KPKIAWTVNDMFI 652
Query: 269 FHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAM 328
R R+ DG+L + P DAG Y C+ SN ++ L + ++ +
Sbjct: 653 VG----SHRYRMTSDGTLFIKNAAPKDAGIYGCLASNS-AGTDKQNSTLRYIEAPKLMVV 707
Query: 329 PPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNED 388
E + +G V+ C PP V W K L+ F G L I +
Sbjct: 708 QSELLVALGDITVMECKTSGIPPPQ-VKWFKGDLELRPSTFL-IIDPLLGLLKIQETQDL 765
Query: 389 ALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPP 448
G+Y+C N G A V +PP FI+ P + E+G + +PC QG P P
Sbjct: 766 DAGDYTCVAINEAGRATGKITLDV--GSPPVFIQEP-ADVSMEIGSNVTLPCYVQGYPEP 822
Query: 449 VVSWTKVGR--------GLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTN 500
+ W ++ + +Q+ + + IL L G + C A N ++ + T
Sbjct: 823 TIKWRRLDNMPIFSRPFSVSSISQLRTGALFILN-LWASDKGTYICEAENQFGKIQSETT 881
Query: 501 VYVLG-TSPHVVTNVSVVALPKGANVS 526
V V G +P + + SV + +G ++
Sbjct: 882 VTVTGLVAPLIGISPSVANVIEGQQLT 908
Score = 110 bits (275), Expect = 8e-24
Identities = 113/437 (25%), Positives = 178/437 (40%), Gaps = 49/437 (11%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-----LTVNSPPQFQET 141
L G L I +V + G Y C AN + H +TV+ PP + +
Sbjct: 1784 LLNGRKLVIAQAQVSNTGLYRCMA------------ANTAGDHKKEFEVTVHVPPTIKSS 1831
Query: 142 PPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERG 199
+ V + +PV L+C+A G P P +TW + + QG +++Q+ L+I +
Sbjct: 1832 GLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLE 1891
Query: 200 SSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPK--NSTVNASQDVSLACHAEAYPANL 257
+G YTC A++ G QL V PP + K N TV S V L C A P +
Sbjct: 1892 DAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPV 1951
Query: 258 TYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSASAY 316
+W++DN + + L G + + + Q DAG Y CV N SA A
Sbjct: 1952 -ITWYKDN----RLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAIN------SAGA- 1999
Query: 317 LTVLYPAQVTAMPPETPLPIGMPGVIRCPVR-----ANPPLLFVSWTKDGKALQLDKFPG 371
+ Y QV P + + V+ PVR P ++W KDG + F
Sbjct: 2000 TELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGS--PVSSFSN 2057
Query: 372 WSQGTEGSLIIALGNEDA--LGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYF 429
Q G I+AL + G Y+C N+ G RV + P I ++
Sbjct: 2058 GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV---PPNIMGEEQNVS 2114
Query: 430 QEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEAHGHWEC 486
+ + + + C + PPP ++W K G L G + ++ S L + + G + C
Sbjct: 2115 VLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTC 2174
Query: 487 SASNAVARVATSTNVYV 503
A+N + + NV +
Sbjct: 2175 EATNVAGKTEKNYNVNI 2191
Score = 108 bits (270), Expect = 3e-23
Identities = 136/511 (26%), Positives = 209/511 (40%), Gaps = 67/511 (13%)
Query: 24 PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83
PE +SVV + SV L C+ A PL I W + G+ P+ + S RI
Sbjct: 2393 PENISVVEK--NSVSLTCE----ASGIPLPSITWFKDGW--PVSLS---NSVRI------ 2435
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ-ETP 142
L G L++ +ED G Y C V E+ G L+V PP E
Sbjct: 2436 ---LSGGRMLRLMQTTMEDAGQYTCVV---RNAAGEERKIFG----LSVLVPPHIVGENT 2485
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSS 201
++V+E + VTL C G+P+P +TW G+ L + + + G L+I V+ +
Sbjct: 2486 LEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHT 2545
Query: 202 GVYTCQASSTEGSATHATQLLVLGPPVIV-----VPPKNSTVNASQDVSLACHAEAYPAN 256
G YTC ASS G + + L V P I P++ TV + SL C A +YP
Sbjct: 2546 GRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPP- 2604
Query: 257 LTYSWFQDNINVFHISRLQPRVRILVDG-SLRLLATQPDDAGCYTCVPSN---GLLHPPS 312
T +WF+D + +RIL G +L++L Q D+AG Y+CV +N ++
Sbjct: 2605 ATITWFKDGTPL----ESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYE 2660
Query: 313 ASAYL-TVLYPAQVTA---MPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDK 368
Y+ ++ + P E + + + C A P +SW KDG+ L+ D
Sbjct: 2661 VKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPS-ASLSWYKDGQPLKSDD 2719
Query: 369 FPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVT-RVLLKAPPAFIERPKEE 427
+ +L I G Y+C N AG + V ++ PP+F + +
Sbjct: 2720 HVNIAANGH-TLQIKEAQISDTGRYTCVASN---IAGEDELDFDVNIQVPPSFQKLWEIG 2775
Query: 428 YFQEVGRE-----------LLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLIL 473
+ GR + + C PPP ++W K G L +V L +
Sbjct: 2776 NMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQI 2835
Query: 474 RPLTKEAHGHWECSASNAVARVATSTNVYVL 504
E G + C A N + +V VL
Sbjct: 2836 PRAKVEDAGRYTCVAVNEAGEDSLQYDVRVL 2866
Score = 108 bits (269), Expect = 4e-23
Identities = 111/415 (26%), Positives = 165/415 (39%), Gaps = 28/415 (6%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVL 146
L +G + IE ++ D G Y+C A + L V+ P + V
Sbjct: 1970 LNRGQIIDIESAQISDAGIYKCVAI-------NSAGATELFYSLQVHVAPSISGSNNMVA 2022
Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSGVY 204
V PV L C ARG P P +TW G + +QV +G L + + +G Y
Sbjct: 2023 VVVN-NPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRY 2081
Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
TC A + G L V PP I+ +N +V SQ V L C ++A P T +W +D
Sbjct: 2082 TCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPP-TLTWLKD 2140
Query: 265 NINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPA 323
H +P + I + S L++ Q D G YTC +N + + + + P
Sbjct: 2141 G----HPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATN-VAGKTEKNYNVNIWVPP 2195
Query: 324 QVTAMPPETPLPIGMPGVIR--CPVRANPPLLFVSWTKDGKALQLDKFPG---WSQGTEG 378
+ T L + +I C PP + W K G + D S G +
Sbjct: 2196 NIGGSDELTQLTVIEGNLISLLCESSGIPPPNLI-WKKKGSPVLTDSMGRVRILSGGRQL 2254
Query: 379 SLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLI 438
+ IA ++ AL YSC N GTA +V ++ E G+ + +
Sbjct: 2255 QISIAEKSDAAL--YSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISL 2312
Query: 439 PCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEAHGHWECSASN 490
C QG PPP V+W K G L +G +D L L+ + G + C A N
Sbjct: 2313 ECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVN 2367
Score = 104 bits (260), Expect = 4e-22
Identities = 117/415 (28%), Positives = 171/415 (41%), Gaps = 36/415 (8%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGS-WVHLTVNSPPQFQETPP-AVLE 147
G LQ+ ED G Y C I ++ S L V PP + +
Sbjct: 3488 GMVLQLLKAETEDSGKYTC--------IASNEAGEVSKHFILKVLEPPHINGSEEHEEIS 3539
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSGVYT 205
V P+ L C+A G P P +TW G+ L Q QVQ G LRI + +G YT
Sbjct: 3540 VIVNNPLELTCIASGIPAPKMTWMKDGRPLPQ-TDQVQTLGGGEVLRISTAQVEDTGRYT 3598
Query: 206 CQASSTEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
C ASS G + V PP I P++ TV ++ V+L C ++A P + +W +
Sbjct: 3599 CLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV-ITWLR 3657
Query: 264 DNINVFHISRLQ--PRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVL 320
+ RLQ PRVRIL G L++ D YTCV SN + + LTV
Sbjct: 3658 NG------ERLQATPRVRILSGGRYLQINNADLGDTANYTCVASN-IAGKTTREFILTVN 3710
Query: 321 YPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 380
P + P + + V+ C + P ++W KDG A+ +S G L
Sbjct: 3711 VPPNIKGGPQSLVILLNKSTVLEC-IAEGVPTPRITWRKDG-AVLAGNHARYSILENGFL 3768
Query: 381 IIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 440
I + G Y C N+ GT +V PP+ P V + + C
Sbjct: 3769 HIQSAHVTDTGRYLCMATNAAGTDRRRIDLQV--HVPPSIAPGP-TNMTVIVNVQTTLAC 3825
Query: 441 SAQGDPPPVVSWTKVGRGL-----QGQAQVDSNSSLILRPLTKEAHGHWECSASN 490
A G P P ++W K G L Q ++ S+ SL++ + + +EC+ +N
Sbjct: 3826 EATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTN 3880
Score = 104 bits (259), Expect = 6e-22
Identities = 132/500 (26%), Positives = 192/500 (38%), Gaps = 48/500 (9%)
Query: 25 EVVSVVG-RAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83
E +SVV R G SV L C+ + P VI W + G ++ +
Sbjct: 3064 ESLSVVNVREGTSVSLECE----SNAVPPPVITWYKNGRMITESTHVEI----------- 3108
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
L G L I+ V D G Y CR ++ D N HL V PP +
Sbjct: 3109 ---LADGQMLHIKKAEVSDTGQYVCRAI----NVAGRDDKN---FHLNVYVPPSIEGPER 3158
Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNG--TLRIRRVERGS 200
V+ PVTL C A G P P + W K + +V++ +G L+I R +
Sbjct: 3159 EVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSD 3218
Query: 201 SGVYTCQASSTEGSATHATQLLVLGPPVIVVP--PKNSTVNASQDVSLACHAEAYPANLT 258
SG YTC AS+ EG A L + PP + P + +V ++V L C+A P L
Sbjct: 3219 SGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPL- 3277
Query: 259 YSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPP---SAS 314
W +D + S R+R+ +GS L + D G YTCV +N + +
Sbjct: 3278 IQWLKDGKPI--ASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLN 3335
Query: 315 AYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQ 374
Y+T L + I C PP ++W K+G L L
Sbjct: 3336 VYVTPTIRGNKDEAEKLMTL-VDTSINIECRATGTPPPQ-INWLKNGLPLPLSSHIRLLA 3393
Query: 375 GTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF-IERPKEEYFQEVG 433
+ I+ D + Y+C N G +V APP EE G
Sbjct: 3394 AGQVIRIVRAQVSD-VAVYTCVASNRAGVDNKHYNLQVF--APPNMDNSMGTEEITVLKG 3450
Query: 434 RELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD-SNSSLILRPLTKEAH--GHWECSASN 490
+ C G P P ++W + G+ L A + S ++L+ L E G + C ASN
Sbjct: 3451 SSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASN 3510
Query: 491 AVARVATSTNVYVLGTSPHV 510
V+ + VL PH+
Sbjct: 3511 EAGEVSKHFILKVL-EPPHI 3529
Score = 102 bits (254), Expect = 2e-21
Identities = 99/376 (26%), Positives = 158/376 (42%), Gaps = 21/376 (5%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP---AVL 146
G +LQI +V D G Y C + + F+ LTV PP ++ +V+
Sbjct: 3017 GRTLQIIRAKVSDGGEYTC-IAINQAGESKKKFS------LTVYVPPSIKDHDSESLSVV 3069
Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYT 205
V+E V+L C + P P +TW G+ + + ++ L I++ E +G Y
Sbjct: 3070 NVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYV 3129
Query: 206 CQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA-SQDVSLACHAEAYPANLTYSWFQD 264
C+A + G L V PP I P + V S V+L C A P T +W ++
Sbjct: 3130 CRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPP-TIAWLKN 3188
Query: 265 NINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPA 323
+ + + L+ VRIL GS L++ +Q D+G YTC+ SN + +L++ P
Sbjct: 3189 HKRIENSDSLE--VRILSGGSKLQIARSQHSDSGNYTCIASN-MEGKAQKYYFLSIQVPP 3245
Query: 324 QVTA--MPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 381
V +P + + +G + C P L + W KDGK + + GS +
Sbjct: 3246 SVAGAEIPSDVSVLLGENVELVCNANGIPTPL-IQWLKDGKPIASGETERIRVSANGSTL 3304
Query: 382 IALGNEDA-LGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 440
G + G+Y+C N G V + + E+ V + I C
Sbjct: 3305 NIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIEC 3364
Query: 441 SAQGDPPPVVSWTKVG 456
A G PPP ++W K G
Sbjct: 3365 RATGTPPPQINWLKNG 3380
Score = 100 bits (248), Expect = 1e-20
Identities = 124/497 (24%), Positives = 195/497 (39%), Gaps = 47/497 (9%)
Query: 22 GKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDY 81
G E+ + G + L C+ +G PP ++I W + G SP + D
Sbjct: 2199 GSDELTQLTVIEGNLISLLCE---SSGIPPPNLI-WKKKG------------SPVLT-DS 2241
Query: 82 VGRVR-LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQE 140
+GRVR L G LQI D Y C V + ++ ++ T+ +
Sbjct: 2242 MGRVRILSGGRQLQISIAEKSDAALYSC-VASNVAGTAKKEYNLQVYIRPTITN----SG 2296
Query: 141 TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERG 199
+ P + V + ++L C +G P P VTW G L + +G + G L+++ +
Sbjct: 2297 SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVS 2356
Query: 200 SSGVYTCQASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPAN 256
+G Y C A + G L V PP I+ P+N +V VSL C A P
Sbjct: 2357 DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLP 2416
Query: 257 LTYSWFQDNINVFHISRLQPRVRILVDG-SLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
+ +WF+D V L VRIL G LRL+ T +DAG YTCV N
Sbjct: 2417 -SITWFKDGWPV----SLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFG 2471
Query: 316 YLTVLYPAQVTA--MPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWS 373
L+VL P + + + + C V N P+ ++W KDG+ LQ D+
Sbjct: 2472 -LSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGN-PVPEITWHKDGQPLQEDEA---H 2526
Query: 374 QGTEGSLIIALGNEDA--LGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI--ERPKEEYF 429
G + + N G Y+C + G S V + A + + E+
Sbjct: 2527 HIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVT 2586
Query: 430 QEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWEC 486
+ + C A PP ++W K G L+ + +L + ++ G + C
Sbjct: 2587 VILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSC 2646
Query: 487 SASNAVARVATSTNVYV 503
A+N + V V
Sbjct: 2647 VATNEAGEMIKHYEVKV 2663
Score = 98.2 bits (243), Expect = 4e-20
Identities = 107/417 (25%), Positives = 165/417 (39%), Gaps = 41/417 (9%)
Query: 128 VHLTVNSPPQ-------FQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQ- 179
V LTV P+ + P + V E VTL C + P P +TW + +
Sbjct: 1064 VQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPF 1123
Query: 180 GQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN 239
+ +G+++I SG+Y C A++ G+ T A +L V PP I PK+ V
Sbjct: 1124 SPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQ 1183
Query: 240 ASQDVSLACHAEAYPANLTYSWFQDNINVF-----HISRLQPRVRILVDGSLRLLATQPD 294
Q V + C+A+ P + +W + + H+S DG+L + P
Sbjct: 1184 VGQRVDIPCNAQGTPLPV-ITWSKGGSTMLVDGEHHVSN--------PDGTLSIDQATPS 1234
Query: 295 DAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPI-----GMPGVIRCPVRAN 349
DAG YTCV +N + L V P V + P CP +
Sbjct: 1235 DAGIYTCVATN-IAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGT 1293
Query: 350 PPLLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLGTAGPSP 408
P + W +G+ L + PG S +G+ L+IA GEY C N GT
Sbjct: 1294 PKPT-IKWLHNGREL-TGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKY 1351
Query: 409 VTRVLLKAPPAFIERPKEEYFQEVGRELL-IPCSAQGDPPPVVSWTKVGRGLQGQAQVDS 467
+V PP ++ + + +L + C +G P P++ W K + + + +
Sbjct: 1352 NLKV--HVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQT 1409
Query: 468 -NSSLILR--PLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTN----VSVV 517
N+ IL+ T E G + C A N N+ VL + TN VSVV
Sbjct: 1410 VNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVV 1466
Score = 98.2 bits (243), Expect = 4e-20
Identities = 124/511 (24%), Positives = 201/511 (39%), Gaps = 44/511 (8%)
Query: 10 LSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQ 69
LS+ + G P VSV+ GE+V L C+ A P +I+WL+ G
Sbjct: 3239 LSIQVPPSVAGAEIPSDVSVL--LGENVELVCN----ANGIPTPLIQWLKDG-------- 3284
Query: 70 FGLYSPRIDPDYVGRVRLQ-KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWV 128
I R+R+ G++L I G D G Y C E+D V
Sbjct: 3285 -----KPIASGETERIRVSANGSTLNIYGALTSDTGKYTC---VATNPAGEEDRIFNLNV 3336
Query: 129 HLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQVQ 187
++T E + V + + C A G+P P + W G L ++
Sbjct: 3337 YVTPTIRGNKDEAEKLMTLVDT--SINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAA 3394
Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVS 245
+RI R + VYTC AS+ G L V PP + + + TV S
Sbjct: 3395 GQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTS 3454
Query: 246 LACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN 305
+AC + PA + +W +D + + L +V L+LL + +D+G YTC+ SN
Sbjct: 3455 MACITDGTPAP-SMAWLRDGQPLGLDAHLTVSTHGMV---LQLLKAETEDSGKYTCIASN 3510
Query: 306 GLLHPPSASAYLTVLYPAQVTAMP--PETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKA 363
S L VL P + E + + P + C + + P ++W KDG+
Sbjct: 3511 E-AGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTC-IASGIPAPKMTWMKDGRP 3568
Query: 364 L-QLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIE 422
L Q D+ + G L I+ + G Y+C + G + RV + A +
Sbjct: 3569 LPQTDQVQ--TLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTD 3626
Query: 423 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKE 479
P++ R++ + C + PPPV++W + G LQ +V L +
Sbjct: 3627 EPRDITVLR-NRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLG 3685
Query: 480 AHGHWECSASNAVARVATSTNVYVLGTSPHV 510
++ C ASN +A T + + P++
Sbjct: 3686 DTANYTCVASN-IAGKTTREFILTVNVPPNI 3715
Score = 97.8 bits (242), Expect = 5e-20
Identities = 112/444 (25%), Positives = 170/444 (38%), Gaps = 43/444 (9%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
R+R SL+++ ++ D G Y C V + ++ + V LTV PP+ P
Sbjct: 567 RIRTLANLSLELKSVKFNDAGEYHCMV-------SSEGGSSAASVFLTVQEPPKVTVMPK 619
Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGV 203
E V++ C A G P P + W + + +GTL I+ +G+
Sbjct: 620 NQSFTGGSE-VSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGI 678
Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
Y C AS++ G+ + L + P ++V V + C P WF+
Sbjct: 679 YGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPP-QVKWFK 737
Query: 264 DNINVFHISRLQPRVRILVD---GSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVL 320
++ L+P +++D G L++ TQ DAG YTCV N + L V
Sbjct: 738 GDL------ELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINE-AGRATGKITLDVG 790
Query: 321 YPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFP---------G 371
P P + + IG + C V+ P + W + LD P
Sbjct: 791 SPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPT-IKWRR------LDNMPIFSRPFSVSS 843
Query: 372 WSQGTEGSLIIALGNEDALGEYSCTPYNSLG-TAGPSPVTRVLLKAPPAFIERPKEEYFQ 430
SQ G+L I G Y C N G + VT L AP I +
Sbjct: 844 ISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIE 903
Query: 431 EVGRELLIPCS-AQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPLTKEAHGHWECS 487
G++L +PC+ G+P P W K L V S+ SL + + + G + C
Sbjct: 904 --GQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCV 961
Query: 488 ASNAVA--RVATSTNVYVLGTSPH 509
ASN TS V+VL T H
Sbjct: 962 ASNVAGTNNKTTSVVVHVLPTIQH 985
Score = 97.8 bits (242), Expect = 5e-20
Identities = 89/325 (27%), Positives = 140/325 (43%), Gaps = 23/325 (7%)
Query: 82 VGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQET 141
+G+ + L +E + +ED G+Y C + ED V LTV+ P F E
Sbjct: 4213 LGKYTAEPYGELILENVVLEDSGFYTC---VANNAAGEDTHT----VSLTVHVLPTFTEL 4265
Query: 142 PPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSS 201
P V + + E + L C A G PLP +TW + V + L I RV + S
Sbjct: 4266 PGDV-SLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVN-GHSELVIERVSKEDS 4323
Query: 202 GVYTCQASSTEGSATHATQLLVLGPPVIVVP-PKNSTVNASQDVSLACHAEAYPANLTYS 260
G Y C A ++ G + V PPV P N + L C + P T
Sbjct: 4324 GTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTP-TIQ 4382
Query: 261 WFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN--GLLHPPSASAYLT 318
W + +++ + R+R L +GSL + T +DAG YTCV +N G++ S LT
Sbjct: 4383 WNRKGVDI----EISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVV---ERSMSLT 4435
Query: 319 VLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG 378
+ P +T P ET + G ++ C P ++W++ G ++ D + +
Sbjct: 4436 LQSPPIITLEPVETVINAGGKIILNCQATGEPQPT-ITWSRQGHSISWD--DRVNVLSNN 4492
Query: 379 SLIIALGNEDALGEYSCTPYNSLGT 403
SL IA ++ E+ C N +G+
Sbjct: 4493 SLYIADAQKEDTSEFECVARNLMGS 4517
Score = 94.7 bits (234), Expect = 4e-19
Identities = 113/416 (27%), Positives = 172/416 (41%), Gaps = 37/416 (8%)
Query: 151 LEPVTLRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQAS 209
L+P + C S LP +R G LG Q + + L I +V G Y C A
Sbjct: 444 LQPGQIPCSV-DSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAV 502
Query: 210 STEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC-HAEAYPANLTYSWFQDNINV 268
S+ G+ T V PP ++ P N TV + L C A NLT+ ++ +
Sbjct: 503 SSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRL 562
Query: 269 FHISRLQPRVRILVDGSLRLLATQPDDAGCYTC-VPSNGLLHPPSASAYLTVLYPAQVTA 327
R+R L + SL L + + +DAG Y C V S G +AS +LTV P +VT
Sbjct: 563 AE----PARIRTLANLSLELKSVKFNDAGEYHCMVSSEG--GSSAASVFLTVQEPPKVTV 616
Query: 328 MPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNE 387
MP G I C P ++WT + + + + ++G+L I
Sbjct: 617 MPKNQSFTGGSEVSIMCSATGYPKPK-IAWTVND--MFIVGSHRYRMTSDGTLFIKNAAP 673
Query: 388 DALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPP 447
G Y C NS GT + R ++AP + + E +G ++ C G PP
Sbjct: 674 KDAGIYGCLASNSAGTDKQNSTLR-YIEAPKLMV--VQSELLVALGDITVMECKTSGIPP 730
Query: 448 PVVSWTKVGRGLQGQAQVDSNSSLILRPL--------TKEAH-GHWECSASNAVARVATS 498
P V W K G ++ ++ LI+ PL T++ G + C A N R AT
Sbjct: 731 PQVKWFK------GDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGR-ATG 783
Query: 499 TNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVW----YTPLAKRP 550
+G+ P + + V++ G+NV+ P + GY + W P+ RP
Sbjct: 784 KITLDVGSPPVFIQEPADVSMEIGSNVTL-PCYVQGYPEPTIKWRRLDNMPIFSRP 838
Score = 94.4 bits (233), Expect = 6e-19
Identities = 123/503 (24%), Positives = 196/503 (38%), Gaps = 45/503 (8%)
Query: 27 VSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRID-------- 78
++ GRA + L P + P V + LP ++Q G P I
Sbjct: 775 INEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQ-GYPEPTIKWRRLDNMP 833
Query: 79 ----PDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFAN-GSWVHLTVN 133
P V + + +L I L D+G Y C E+ F S +TV
Sbjct: 834 IFSRPFSVSSISQLRTGALFILNLWASDKGTYICEA--------ENQFGKIQSETTVTVT 885
Query: 134 S-PPQFQETPPAVLEVQELEPVTLRC-VARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTL 191
P+V V E + +TL C + G+P+P W L Q +G+L
Sbjct: 886 GLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSL 945
Query: 192 RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAE 251
I RV+ G YTC AS+ G+ T ++V P I + + V+L C A
Sbjct: 946 HIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKAS 1005
Query: 252 AYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPP 311
P + W + IS + DGSL +++ +++G Y C +N +
Sbjct: 1006 GNP-KPSVIWSKKG---ELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGY-A 1060
Query: 312 SASAYLTVLYPAQVTA--------MPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKA 363
LTV +V P E + G + C V++ PP + ++W K+ +
Sbjct: 1061 KRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI-ITWAKETQL 1119
Query: 364 LQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIER 423
+ P + GS+ I G Y C N G + ++ + PP
Sbjct: 1120 IS-PFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNV--TQAVKLNVHVPPKIQRG 1176
Query: 424 PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDS-NSSLILRPLTKEA 480
PK Q VG+ + IPC+AQG P PV++W+K G + G+ V + + +L + T
Sbjct: 1177 PKHLKVQ-VGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD 1235
Query: 481 HGHWECSASNAVARVATSTNVYV 503
G + C A+N T ++V
Sbjct: 1236 AGIYTCVATNIAGTDETEITLHV 1258
Score = 94.0 bits (232), Expect = 8e-19
Identities = 106/430 (24%), Positives = 170/430 (39%), Gaps = 54/430 (12%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETP---P 143
L G LQI +VED G Y C ED + V PP + P
Sbjct: 2827 LPGGRVLQIPRAKVEDAGRYTCVAV---NEAGEDSLQ----YDVRVLVPPIIKGANSDLP 2879
Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSSG 202
+ V + + C++ GSP P +W+ G+ L + + NG L+I + G
Sbjct: 2880 EEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIG 2939
Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPP-KNSTVNASQDVSLACHAEAYPANLTYSW 261
Y C A +T GSA L V PP ++ P +N TV + +SL C +P SW
Sbjct: 2940 RYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPP-DLSW 2998
Query: 262 FQDNINVFHISRLQPRVRILVDG-SLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVL 320
++ + +L I+ G +L+++ + D G YTC+ N + LTV
Sbjct: 2999 LKNEQPI----KLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFS-LTVY 3053
Query: 321 YPAQVTAMPPETPLPI----GMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGT 376
P + E+ + G + C A PP + ++W K+G+ + T
Sbjct: 3054 VPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPV-ITWYKNGRMI-----------T 3101
Query: 377 EGSLIIALGNEDAL----------GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKE 426
E + + L + L G+Y C N G + V + P IE P+
Sbjct: 3102 ESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYV---PPSIEGPER 3158
Query: 427 EYFQE-VGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD-----SNSSLILRPLTKEA 480
E E + + + C A G PPP ++W K + ++ ++ S L +
Sbjct: 3159 EVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSD 3218
Query: 481 HGHWECSASN 490
G++ C ASN
Sbjct: 3219 SGNYTCIASN 3228
Score = 88.2 bits (217), Expect = 4e-17
Identities = 109/437 (24%), Positives = 167/437 (38%), Gaps = 34/437 (7%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGS-WVHLTVNSPPQFQETPPAV 145
L G LQI ++ D G Y C + E+ + + +L V+ PP
Sbjct: 2922 LSNGRILQILNTQITDIGRYVC--------VAENTAGSAKKYFNLNVHVPPSVIGPKSEN 2973
Query: 146 LEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERGSSGVY 204
L V ++L C G P P ++W + + + V G TL+I R + G Y
Sbjct: 2974 LTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEY 3033
Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNS----TVNASQDVSLACHAEAYPANLTYS 260
TC A + G + L V PP I S V VSL C + A P + +
Sbjct: 3034 TCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVI-T 3092
Query: 261 WFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTV 319
W+++ + + V IL DG L + + D G Y C N + + +L V
Sbjct: 3093 WYKNGRMITESTH----VEILADGQMLHIKKAEVSDTGQYVCRAIN-VAGRDDKNFHLNV 3147
Query: 320 LYPAQVTAMPPETPLP-IGMPGVIRCPVRANPPLLFVSWTKDGKALQ-LDKFPGWSQGTE 377
P + E + I P + C PP ++W K+ K ++ D
Sbjct: 3148 YVPPSIEGPEREVIVETISNPVTLTCDATGIPPPT-IAWLKNHKRIENSDSLEVRILSGG 3206
Query: 378 GSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELL 437
L IA G Y+C N G A + + A E P + +G +
Sbjct: 3207 SKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVL-LGENVE 3265
Query: 438 IPCSAQGDPPPVVSWTKVGR----GLQGQAQVDSNSSL--ILRPLTKEAHGHWECSASNA 491
+ C+A G P P++ W K G+ G + +V +N S I LT + G + C A+N
Sbjct: 3266 LVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDT-GKYTCVATNP 3324
Query: 492 VARV--ATSTNVYVLGT 506
+ NVYV T
Sbjct: 3325 AGEEDRIFNLNVYVTPT 3341
Score = 85.1 bits (209), Expect = 4e-16
Identities = 109/468 (23%), Positives = 171/468 (36%), Gaps = 56/468 (11%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETP-PAV 145
+ G L++ ED G Y C+ + + + ++ V PP T P
Sbjct: 1410 VNNGKILKLFRATPEDAGRYSCKAINIAG-------TSQKYFNIDVLVPPTIIGTNFPNE 1462
Query: 146 LEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV--QNGTLRIRRVERGSSGV 203
+ V V L C +G+P P + W GK L G V++ + L ++ R G
Sbjct: 1463 VSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGR 1522
Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVS--------LACHAEAYPA 255
Y C S+ G +L I +PP N + D+S L C P
Sbjct: 1523 YQCTVSNAAGKQAKDIKL------TIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPM 1576
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGS--LRLLATQPDDAGCYTCVPSNGLLHPPSA 313
+W++D + S+ + +D L + Q D+ YTC +N +
Sbjct: 1577 P-AITWYKDGQPIMSSSQ-----ALYIDKGQYLHIPRAQVSDSATYTCHVAN-VAGTAEK 1629
Query: 314 SAYLTVLYPAQV---TAMPPETPLPIGMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKF 369
S ++ V P + A P + I + C NP P+L +W KDG ++ +
Sbjct: 1630 SFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPIL--TWLKDGVPVKANDN 1687
Query: 370 PGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVT-RVLLKAPPAFIERPKEEY 428
G + L I E G+Y C + AG + V + PPA + Y
Sbjct: 1688 IRIEAGGK-KLEIMSAQEIDRGQYICV---ATSVAGEKEIKYEVDVLVPPAIEGGDETSY 1743
Query: 429 FQEVGRELL-IPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEAHGHW 484
F + LL + C G PPP + W K G+ + G + + L++ G +
Sbjct: 1744 FIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLY 1803
Query: 485 ECSASNAV--------ARVATSTNVYVLGTSPHVVTNVSVVALPKGAN 524
C A+N V + G S VV VAL AN
Sbjct: 1804 RCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIAN 1851
Score = 83.6 bits (205), Expect = 1e-15
Identities = 114/485 (23%), Positives = 189/485 (38%), Gaps = 51/485 (10%)
Query: 48 GRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYE 107
G PP I WL+ G LP+ L L G ++I +V D Y
Sbjct: 3368 GTPPPQ-INWLKNGLPLPLSSHIRL--------------LAAGQVIRIVRAQVSDVAVYT 3412
Query: 108 CRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAV-LEVQELEPVTLRCVARGSPLP 166
C + +L V +PP + + V + ++ C+ G+P P
Sbjct: 3413 CVA-------SNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAP 3465
Query: 167 HVTWKLRGKDLG-QGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLG 225
+ W G+ LG V L++ + E SG YTC AS+ G + L VL
Sbjct: 3466 SMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLE 3525
Query: 226 PPVIVVPPKNSTVN--ASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVD 283
PP I ++ ++ + + L C A PA +W +D + ++Q L
Sbjct: 3526 PPHINGSEEHEEISVIVNNPLELTCIASGIPAP-KMTWMKDGRPLPQTDQVQ----TLGG 3580
Query: 284 GS-LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQV--TAMPPETPLPIGMPG 340
G LR+ Q +D G YTC+ S+ + V P + T P + +
Sbjct: 3581 GEVLRISTAQVEDTGRYTCLASSP-AGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQV 3639
Query: 341 VIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGE---YSCTP 397
+ C A PP + ++W ++G+ LQ + G + + N D LG+ Y+C
Sbjct: 3640 TLECKSDAVPPPV-ITWLRNGERLQATP---RVRILSGGRYLQINNAD-LGDTANYTCVA 3694
Query: 398 YNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR 457
N AG + +L P I+ + + + ++ C A+G P P ++W K G
Sbjct: 3695 SN---IAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGA 3751
Query: 458 GLQG---QAQVDSNSSLILRPLTKEAHGHWECSASNAVA--RVATSTNVYVLGTSPHVVT 512
L G + + N L ++ G + C A+NA R V+V + T
Sbjct: 3752 VLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPT 3811
Query: 513 NVSVV 517
N++V+
Sbjct: 3812 NMTVI 3816
Score = 47.4 bits (111), Expect = 8e-05
Identities = 52/215 (24%), Positives = 83/215 (38%), Gaps = 33/215 (15%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
G + +L C++ P I+W R G +D + R+R SL
Sbjct: 4364 GGNAILNCEVKGD----PTPTIQWNRKG---------------VDIEISHRIRQLGNGSL 4404
Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
I G ED G Y C V + + E + LT+ SPP P + +
Sbjct: 4405 AIYGTVNEDAGDYTC-VATNEAGVVERSMS------LTLQSPPIITLEPVETV-INAGGK 4456
Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEG 213
+ L C A G P P +TW +G + + N +L I ++ + + C A + G
Sbjct: 4457 IILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516
Query: 214 SATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC 248
S +LV P ++ V S +A + S+ C
Sbjct: 4517 S------VLVRVPVIVQVHGGFSQWSAWRACSVTC 4545
Score = 36.2 bits (82), Expect = 0.19
Identities = 47/205 (22%), Positives = 83/205 (40%), Gaps = 12/205 (5%)
Query: 312 SASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG 371
S+ ++ +++ A MP +TP PG I C V + P +S+ ++G L +D++
Sbjct: 419 SSVSFSSIVPDAPKVTMPEKTPGYYLQPGQIPCSVDSLLPFT-LSFVRNGVTLGVDQY-- 475
Query: 372 WSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQE 431
+ +L IA G Y C +S GT T + PP I+ P
Sbjct: 476 LKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQ--TFFDVSEPPPVIQVPNNVTVTP 533
Query: 432 VGRELLIPCSAQGDPPPVVSWTKVGRGLQ----GQAQVDSNSSLILRPLTKEAHGHWECS 487
G ++ C ++W + R ++ + + +N SL L+ + G + C
Sbjct: 534 -GERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCM 592
Query: 488 ASNAVARVATSTNVYVLGTSPHVVT 512
S+ A S V++ P VT
Sbjct: 593 VSSEGGSSAAS--VFLTVQEPPKVT 615
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 130 bits (328), Expect = 6e-30
Identities = 155/596 (26%), Positives = 243/596 (40%), Gaps = 74/596 (12%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F+++P V+ V EP L CV RG P P V+W+ G L + +G++ ++ G L +
Sbjct: 168 FRQSPGNVV-VAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHT 226
Query: 197 ERGSSGVYTCQASSTEGS-ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G+Y C AS+ G + A +++VL P + P N V A V+ C + P
Sbjct: 227 LKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPP 286
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
W +++ + R I D SL + +D G YTCV N + AS
Sbjct: 287 P-RLRWRKEDGEL-----PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENS-VGRAEASG 339
Query: 316 YLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG---- 371
L+V P Q+ P + G +C + NPP + W K+G + L FP
Sbjct: 340 SLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPA-IFWQKEGSQVLL--FPSQSLQ 396
Query: 372 ----WSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRV----LLKAPPAFIER 423
+S G L I G Y C + G+ + + L PP ++
Sbjct: 397 PTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQG 456
Query: 424 PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQG---QAQVDSNSSLILRPLTKEA 480
P + +G + +PC G+P P V W K G+ LQG Q + +N +L + + +
Sbjct: 457 PANQTL-VLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMD 515
Query: 481 HGHWECSASNAVARVATSTNVYV---LGTSPHVVTNVS----------VVALPKGA-NVS 526
G + C A ++ S + + G SP T S V + K + ++
Sbjct: 516 MGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLT 575
Query: 527 WEPGFDGGYLQRFSV--WYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSV 584
W+P G V ++P A + W ++A V V GLQP+T Y F V
Sbjct: 576 WKPNPQTGAAVTSYVIEAFSPAA------GNTWRTVADGVQLETHTVSGLQPNTIYLFLV 629
Query: 585 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGL--VAVRT------- 635
A G S + E + T ++P P + P +GL VAVR
Sbjct: 630 RAVGAWGLSEPSPV----SEPVRTQDSSPSRP---VEDPWRGQQGLAEVAVRLQEPIVLG 682
Query: 636 PRGVLLHW---DPPELVPKRLDGYVLEGRQGSQGWEVLD---PAVAGTETELLVPG 685
PR + + W P +LV + + G +G W +LD P+ T L PG
Sbjct: 683 PRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGG-SWTMLDLQSPSQQSTVLRGLPPG 737
Score = 128 bits (322), Expect = 3e-29
Identities = 271/1145 (23%), Positives = 405/1145 (35%), Gaps = 193/1145 (16%)
Query: 28 SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRL 87
+VV GE VL C +PP G P V W + G L + GR+ +
Sbjct: 174 NVVVAVGEPAVLEC--VPPRGHPEPSV-SWRKDGARLK--------------EEEGRITI 216
Query: 88 QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLE 147
+ G + L+ D G Y C + + + V P F P +
Sbjct: 217 RGGKLMMSHTLK-SDAGMYVCVASNMAGE------RESAAAEVMVLERPSFLRRPVNQVV 269
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQ 207
+ + PVT C +G P P + W+ +L G+ +++ + +L I V G YTC
Sbjct: 270 LADA-PVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDH-SLWIGHVSAEDEGTYTCV 327
Query: 208 ASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
A ++ G A + L V PP +V P++ + V+ C + P + W ++
Sbjct: 328 AENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIF-WQKEGSQ 386
Query: 268 V--FHISRLQPRVRILVD--GSLRLLATQPDDAGCYTC--------VPSNGLLHPPSASA 315
V F LQP R V G L + A Q DAG Y C + + LL AS
Sbjct: 387 VLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGAS- 445
Query: 316 YLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQG 375
L L P + P L +G + C V NP V W KDG+ LQ D +
Sbjct: 446 -LDGLPPV-ILQGPANQTLVLGSSVWLPCRVTGNPQPS-VRWKKDGQWLQGDDLQ-FKTM 501
Query: 376 TEGSLIIALGNEDALGEYSCTPYNSLGTA------------GPSPVTRVLLKAPPAFIER 423
G+L IA E +G YSC +S G A G SP +PP
Sbjct: 502 ANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPG---A 558
Query: 424 PKEEYFQEVGRELLI----PCSAQG-----------DPPPVVSWTKVGRGLQGQAQVDSN 468
P + E+ + + P G P +W V G+Q + S
Sbjct: 559 PSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSG 618
Query: 469 SSLILRPLT-----KEAHGHWECSASNAVARVATSTNVYVLGTSPH-------------- 509
L+P T A G W S + V S V +SP
Sbjct: 619 ----LQPNTIYLFLVRAVGAWGLSEPSPV-----SEPVRTQDSSPSRPVEDPWRGQQGLA 669
Query: 510 ---VVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGA 566
V +V P+ VSW +Q F V + P+ + L P
Sbjct: 670 EVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAG--PEGGSWTMLDLQSPSQQ 727
Query: 567 AHLLVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAPEGLPTTPAAPGLPPTEIPPPLS 625
+ +L GL P TQ Q V AQ + G G S + S PE P+
Sbjct: 728 STVL-RGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPS----------------G 770
Query: 626 PPRGLVAVRTPRG---VLLHWDPPELVPKRLDGYVLEGR---QGSQGWEVLDPAVAGTET 679
PP+G+ G + + W+PP +P + +G + E + G++ L+ + AG
Sbjct: 771 PPQGVAVALGGDGNSSITVSWEPP--LPSQQNGVITEYQIWCLGNESRFHLNRSAAGWAR 828
Query: 680 ELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVS-------TSGLEVYPS-RTQLPGLL 731
++ GL+ +LY + A + V PS V GLEV +L +L
Sbjct: 829 SAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRLARVL 888
Query: 732 PQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPS 791
+P G C A+L+ + A RR++++ F+ T + P
Sbjct: 889 REPAFLAGSGAAC---GALLLGLCAALYW------RRKQRKELSHYTASFAYTPAVSFPH 939
Query: 792 ALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDG 851
+ G S + L +P L S W P+ +PS +P S P P PD
Sbjct: 940 SEGLSGASSRPPMGLGPAPYSWLADS--WPHPSRSPSAQ-EPRGS--CCPSNP---DPDD 991
Query: 852 RFVMGPTVAAPQERSGREQAEPR--------TPAQRLARSFDCS-SSSPSG--------A 894
R+ ++ ++ R A P PA ++F PSG A
Sbjct: 992 RYYNEAGISLYLAQTARGTAAPGEGPVYSTIDPAGEELQTFHGGFPQHPSGDLGPWSQYA 1051
Query: 895 PQPLCIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPP 943
P D PV P P LP P P + LS E ++G P
Sbjct: 1052 PPEWSQGDSGAKGGKVKLLGKPVQMPSLNWPEALPPPPPSCE-LSCLEGPEEELEGSSEP 1110
Query: 944 LEEPSPAAPPDYMDTRRCPTSSFLRSP---ETPPVSPRESLPGAVVGAGATAEPPYTALA 1000
EE P P T + L +P ETP +P + +PP
Sbjct: 1111 -EEWCPPMPERSHLTEPSSSGGCLVTPSRRETPSPTPSYGQQSTATLTPSPPDPPQPPTD 1169
Query: 1001 DWTLRERLLPGLLPAAPRGSLTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWAS 1060
L + +P +P P L+ G A A +LSP+P +++ ++
Sbjct: 1170 MPHLHQ--MPRRVPLGPSSPLSVSQPMLGIREARPAGLGAGPAASPHLSPSPAPSTASSA 1227
Query: 1061 GPERW 1065
W
Sbjct: 1228 PGRTW 1232
Score = 119 bits (298), Expect = 2e-26
Identities = 155/622 (24%), Positives = 243/622 (39%), Gaps = 58/622 (9%)
Query: 118 PEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDL 177
P D NGS V ++ P+ E PP +L V EP TL C A G P P++ W G +
Sbjct: 47 PGDPSLNGSRVG-PEDAMPRIVEQPPDLL-VSRGEPATLPCRAEGRPRPNIEWYKNGARV 104
Query: 178 GQGQ-----GQVQVQNGTLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLG 225
+ ++ + +G L R+ G GVYTC A + G+A +A+ + +
Sbjct: 105 ATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVL 164
Query: 226 PPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS 285
P N V + L C + SW +D + + R+ I G
Sbjct: 165 RDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGA---RLKEEEGRITIR-GGK 220
Query: 286 LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCP 345
L + T DAG Y CV SN SA+A + VL P + P C
Sbjct: 221 LMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCE 280
Query: 346 VRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAG 405
V+ +PP + W K+ L ++ ++ SL I + + G Y+C NS+G A
Sbjct: 281 VKGDPPPR-LRWRKEDGELPTGRY---EIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAE 336
Query: 406 PSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG--------R 457
S V PP + +P+++ G + C +G+PPP + W K G +
Sbjct: 337 ASGSLSV--HVPPQLVTQPQDQ-MAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQ 393
Query: 458 GLQ--GQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTS-----PHV 510
LQ G+ V L + + + G++ C A + + + + G S P +
Sbjct: 394 SLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVI 453
Query: 511 VTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLL 570
+ + L G++V W P G Q W K + D + L
Sbjct: 454 LQGPANQTLVLGSSV-WLPCRVTGNPQPSVRW----KKDGQWLQGDDLQFKTMANGT-LY 507
Query: 571 VPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTE-IPPPLSPPRG 629
+ +Q +S +A++ G +S L E +P PPTE PP +P +
Sbjct: 508 IANVQEMDMGFYSCVAKSSTGEATWSG-WLKMREDWGVSPD----PPTEPSSPPGAPSQP 562
Query: 630 LVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQG--WE-VLDPAVAGTETELLVPGL 686
+V T + L W P + YV+E + G W V D T T V GL
Sbjct: 563 VVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHT---VSGL 619
Query: 687 IKDVLYEFRLVAFAGSFVSDPS 708
+ +Y F + A +S+PS
Sbjct: 620 QPNTIYLFLVRAVGAWGLSEPS 641
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 127 bits (320), Expect = 5e-29
Identities = 161/604 (26%), Positives = 245/604 (40%), Gaps = 88/604 (14%)
Query: 154 VTLRCVARGSPLP--HVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA--- 208
VTL CVA PL H+ WK G L G + N L I +G Y C+A
Sbjct: 233 VTLECVANARPLIKLHIIWKKDGVLLSGG---ISDHNRRLTIPNPTGSDAGYYECEAVLR 289
Query: 209 SSTEGSATHATQLLVLGPPVIVVPP-KNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
SS+ S L VL PP V P ++ T + V + C A+ P + +W++D
Sbjct: 290 SSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPP-SITWYKDAA- 347
Query: 268 VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPA-QVT 326
V + +L R R DG L++ PDD G + C N S YL V A +T
Sbjct: 348 VVEVEKLT-RFRQRNDGGLQISGLVPDDTGMFQCFARNAA-GEVQTSTYLAVTSIAPNIT 405
Query: 327 AMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLD--KFPGWSQGTEGSLIIAL 384
P ++ + GM V+ C + P ++W K + L + P ++ GSL+I+
Sbjct: 406 RGPLDSTVIDGMSVVLACET-SGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISP 464
Query: 385 GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQG 444
+ G Y+C NS G S V + I +P ++ G + + C
Sbjct: 465 THISDAGTYTCLATNSRGVDEASADLVVWARTR---ITKPPQDQSVIKGTQASMVCGVTH 521
Query: 445 DPPPVVS--WTKVGRGLQGQA----QVDSNSSLILRPLTKEAHGHWECSASNAVARVATS 498
DP + W K G L ++ ++D N SL + G + C +A + S
Sbjct: 522 DPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRS 581
Query: 499 TNVYV--LGTSP-HVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHH 555
++ V L +P H V +S V + N++W FDG +PL + M
Sbjct: 582 AHLRVRQLPHAPEHPVATLSTVER-RAINLTWTKPFDGN---------SPLIRYILEMSE 631
Query: 556 D---WVSLAVPVG--AAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV--LSAPEGLPT 608
+ W L V A + V GL P YQF + A N +G G FS+ +S PE
Sbjct: 632 NNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPE---- 687
Query: 609 TPAAPGLPPTEIPPPLSPPRGLVAV-RTPRGVLLHWDPPELVPKR--LDGYVLEG----- 660
PP +PP+ ++A RT + +++ W PP + L GY++
Sbjct: 688 ------------EPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGL 735
Query: 661 RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV 720
G Q + D V LL+ LI YE + A+ +++GL V
Sbjct: 736 PVGYQFKNITDADV----NNLLLEDLIIWTNYEIEVAAY--------------NSAGLGV 777
Query: 721 YPSR 724
Y S+
Sbjct: 778 YSSK 781
Score = 100 bits (249), Expect = 8e-21
Identities = 132/541 (24%), Positives = 208/541 (38%), Gaps = 56/541 (10%)
Query: 102 DQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVAR 161
D G+YEC +P G++ L+V PPQF + P + + + V + C A+
Sbjct: 278 DAGYYECEAVLRSSSVPS--VVRGAY--LSVLEPPQFVKEPERHITAEMEKVVDIPCQAK 333
Query: 162 GSPLPHVTWKLRGKDLGQGQGQV-----QVQNGTLRIRRVERGSSGVYTCQASSTEGSAT 216
G P P +TW KD + + Q +G L+I + +G++ C A + G
Sbjct: 334 GVPPPSITWY---KDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQ 390
Query: 217 HATQLLVLG-PPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQ 275
+T L V P I P +STV V LAC P +W + + S
Sbjct: 391 TSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAP-RPAITWQKGERILASGSVQL 449
Query: 276 PRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLP 335
PR L GSL + T DAG YTC+ +N ASA L V ++T P + +
Sbjct: 450 PRFTPLESGSLLISPTHISDAGTYTCLATNS-RGVDEASADLVVWARTRITKPPQDQSVI 508
Query: 336 IGMPGVIRCPVRANPPL-LFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYS 394
G + C V +P + + W KDG L + P GSL I+ +G Y+
Sbjct: 509 KGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYT 568
Query: 395 CTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSA--QGDPPPV--- 449
C ++ G S RV + P E P R + + + G+ P +
Sbjct: 569 CRVISAGGNDSRSAHLRV--RQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYI 626
Query: 450 -------VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVAR--VATSTN 500
WT + + +A +S+ ++ L + A N V + + T
Sbjct: 627 LEMSENNAPWTVLLASVDPKA-----TSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTE 681
Query: 501 VYVLGTSPHVVTNVSVVA---LPKGANVSWEP-------GFDGGYLQRFSVWYTPLAKRP 550
L P +V+A + + W+P G GY+ R+ + P+ +
Sbjct: 682 RVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQF 741
Query: 551 DRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLS-APEGLPTT 609
+ +LL+ L T Y+ V A N G G +S V +G+PT
Sbjct: 742 KNI--------TDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTV 793
Query: 610 P 610
P
Sbjct: 794 P 794
Score = 77.0 bits (188), Expect = 1e-13
Identities = 61/230 (26%), Positives = 99/230 (43%), Gaps = 14/230 (6%)
Query: 77 IDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPP 136
++ + + R R + LQI GL +D G ++C F E + +L V S
Sbjct: 349 VEVEKLTRFRQRNDGGLQISGLVPDDTGMFQC---FARNAAGEVQTS----TYLAVTSIA 401
Query: 137 QFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQV----QVQNGTLR 192
P V + V L C G+P P +TW+ + L G Q+ +++G+L
Sbjct: 402 PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL 461
Query: 193 IRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEA 252
I +G YTC A+++ G + L+V I PP++ +V S+ C
Sbjct: 462 ISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTH 521
Query: 253 YP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTC 301
P + Y W +D + + PR+R+ +GSL + T D G YTC
Sbjct: 522 DPRVTIRYIWEKDGATLG--TESHPRIRLDRNGSLHISQTWSGDIGTYTC 569
Score = 73.6 bits (179), Expect = 1e-12
Identities = 93/394 (23%), Positives = 154/394 (39%), Gaps = 34/394 (8%)
Query: 136 PQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRR 195
P F+ P E + L C+A GS W ++L + + + I
Sbjct: 26 PYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYM-----ITS 80
Query: 196 VERGSSGVYTCQASSTEGSATHA-TQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYP 254
++R +G Y C + G+ T++ V K+ +V+ + + A
Sbjct: 81 LDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASF 140
Query: 255 ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSAS 314
+WF+D + SR + I ++ +L +L+T DAG Y N S
Sbjct: 141 PQPQVTWFRDGRKIPPSSR----IAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTS 196
Query: 315 AYLTVLY-----PAQVTA----MPPE-TPLPIGMPGV-IRCPVRANPPL-LFVSWTKDGK 362
+T+ PA A +PP+ T + G V + C A P + L + W KDG
Sbjct: 197 QPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGV 256
Query: 363 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKA--PPAF 420
L G L I G Y C + PS V L PP F
Sbjct: 257 LLS-----GGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSV-PSVVRGAYLSVLEPPQF 310
Query: 421 IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQA----QVDSNSSLILRPL 476
++ P+ E+ + + IPC A+G PPP ++W K ++ + + ++ L + L
Sbjct: 311 VKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGL 370
Query: 477 TKEAHGHWECSASNAVARVATSTNVYVLGTSPHV 510
+ G ++C A NA V TST + V +P++
Sbjct: 371 VPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI 404
Score = 52.8 bits (125), Expect = 2e-06
Identities = 41/122 (33%), Positives = 52/122 (42%), Gaps = 16/122 (13%)
Query: 525 VSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSV 584
+SWEPG DG R+ YT + S +V A+ +V L+P T Y+F V
Sbjct: 1420 LSWEPGSDGLSPVRY---YTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRV 1476
Query: 585 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 644
A N +G FSE E L T AAP PT + V T VL+ W
Sbjct: 1477 KATNDIGDSEFSE----ESESLTTLQAAPDEAPTILS---------VTPHTTTSVLIRWQ 1523
Query: 645 PP 646
PP
Sbjct: 1524 PP 1525
Score = 42.7 bits (99), Expect = 0.002
Identities = 52/200 (26%), Positives = 76/200 (38%), Gaps = 41/200 (20%)
Query: 524 NVSWE-PGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAH-----LLVPGLQPH 577
NVSWE P F G L+ + + Y P + D VS V V L V L
Sbjct: 1741 NVSWEAPQFPNGILEGYRLVYEPCSPV------DGVSKIVTVDVKGNSPLWLKVKDLAEG 1794
Query: 578 TQYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP 636
Y+F + A+ V + P EG P P P + VR
Sbjct: 1795 VTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVP-----------------IIVRYS 1837
Query: 637 RGVLLHWDPPELVPKRLDGYVLEGRQGSQG-WEVL---DPAVAGTET---ELLVPGLIKD 689
+ +HW + + YV+E R +G W++L P + T ++L PG
Sbjct: 1838 SAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPG---- 1893
Query: 690 VLYEFRLVAFAGSFVSDPSN 709
V Y+FR++A PS+
Sbjct: 1894 VSYDFRVIAVNDYGFGTPSS 1913
Score = 37.7 bits (86), Expect = 0.065
Identities = 34/131 (25%), Positives = 56/131 (42%), Gaps = 21/131 (16%)
Query: 573 GLQPHTQYQFSVLAQNKLGSGPFSE--IVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGL 630
GL+P + Y F + AQ + G G +E +V + P P+ P + ++
Sbjct: 1364 GLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDV---------- 1413
Query: 631 VAVRTPRGVLLHWDPPE--LVPKRLDGYVLEGRQGSQG-WEVLDPAVAGTETELLVPGLI 687
R VLL W+P L P R Y ++ R+ G W + +V+ + +V L
Sbjct: 1414 ----RARSVLLSWEPGSDGLSPVRY--YTIQTRELPSGRWALHSASVSHNASSFIVDRLK 1467
Query: 688 KDVLYEFRLVA 698
Y+FR+ A
Sbjct: 1468 PFTSYKFRVKA 1478
Score = 34.7 bits (78), Expect = 0.55
Identities = 37/142 (26%), Positives = 60/142 (42%), Gaps = 17/142 (11%)
Query: 571 VPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGL 630
+ L+ T+Y+ V A N +GSGP+S+ V+ T + P PT +
Sbjct: 1162 IEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGR-----TRESVPSSGPTNVS--------- 1207
Query: 631 VAVRTPRGVLLHW-DPPELVPKRLD-GYVLEGRQGSQGWEVLDPAVAGTET-ELLVPGLI 687
T +L+ W + PE L GY + ++ + V G + + GL
Sbjct: 1208 ALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLG 1267
Query: 688 KDVLYEFRLVAFAGSFVSDPSN 709
K VLYE +++AF PS+
Sbjct: 1268 KYVLYEVQVLAFTRIGDGSPSH 1289
Score = 34.3 bits (77), Expect = 0.72
Identities = 33/146 (22%), Positives = 57/146 (39%), Gaps = 20/146 (13%)
Query: 508 PHVVTNVSVVAL-PKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWV---SLAVP 563
P TN+ + + P+ + + PG+DG S W +W+ L+
Sbjct: 993 PGPPTNLGISNIGPRSVTLQFRPGYDGK--TSISRWLVEAQVGVVGEGEEWLLIHQLSNE 1050
Query: 564 VGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPP 623
A + VP L P T Y F + N +G+ P P+ P+ + + PP
Sbjct: 1051 PDARSMEVPDLNPFTCYSFRMRQVNIVGTSP------------PSQPSRK-IQTLQAPPD 1097
Query: 624 LSPPRGLVAVRTPRGVLLHWDP-PEL 648
++P + + + L W P PE+
Sbjct: 1098 MAPANVSLRTASETSLWLRWMPLPEM 1123
Score = 34.3 bits (77), Expect = 0.72
Identities = 47/159 (29%), Positives = 62/159 (38%), Gaps = 21/159 (13%)
Query: 574 LQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAV 633
L +T Y SV A N G GP S P T AAP P + L
Sbjct: 1690 LTGYTAYMVSVAAFNAAGDGP-----RSTPTQGQTQQAAPSAPSSVKFSEL--------- 1735
Query: 634 RTPRGVLLHWDPPELVPKRLDGY--VLEGRQGSQG-WEVLDPAVAG-TETELLVPGLIKD 689
T V + W+ P+ L+GY V E G +++ V G + L V L +
Sbjct: 1736 -TTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEG 1794
Query: 690 VLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLP 728
V Y FR+ A +F P ANV+T E P +P
Sbjct: 1795 VTYRFRI--RAKTFTYGPEIEANVTTGPGEGAPGPPGVP 1831
Score = 33.9 bits (76), Expect = 0.94
Identities = 46/184 (25%), Positives = 69/184 (37%), Gaps = 25/184 (13%)
Query: 519 LPKGANVSW-EPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPH 577
L VSW EPG G L + + + + R+ H +P V GL
Sbjct: 907 LDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTH-----YLPNVTLEYRVTGLTAL 961
Query: 578 TQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPR 637
T Y V A G G S +S+ G+P P PG PPT + ++ PR
Sbjct: 962 TTYTIEVAAMTSKGQGQVSASTISS--GVP--PELPG-PPTNLG---------ISNIGPR 1007
Query: 638 GVLLHWDPPELVPKRLDGYVLEGRQGSQG----WEVLDPAVAGTETELL-VPGLIKDVLY 692
V L + P + +++E + G G W ++ + + VP L Y
Sbjct: 1008 SVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCY 1067
Query: 693 EFRL 696
FR+
Sbjct: 1068 SFRM 1071
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 127 bits (320), Expect = 5e-29
Identities = 113/386 (29%), Positives = 167/386 (43%), Gaps = 21/386 (5%)
Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
V LTV + P + P V V E E V L C A G P P +TW+ G ++ G +
Sbjct: 2658 VFLTVQASPVVKPLPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP 2716
Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
G LRI +G Y C A ++ GSA T+L+V PPVI + + L
Sbjct: 2717 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLP 2776
Query: 248 CHAEAYP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306
C A P N+T W +D V S + + I G L + + DAG YTC N
Sbjct: 2777 CKARGSPEPNIT--WDKDGQPV---SGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENA 2831
Query: 307 LLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQL 366
+ +LT+L T +P + L +G +RC R +P + WT + + +
Sbjct: 2832 -VGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPR-IGWTVNDRPVT- 2888
Query: 367 DKFPGWSQGTEGSLI--IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERP 424
G S+ GS + A+ ED+ G Y C N +G V+ V +K P
Sbjct: 2889 ---EGVSEQDGGSTLQRAAVSREDS-GTYVCWAENRVGRT--QAVSFVHVKEAPVLQGEA 2942
Query: 425 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ--AQVDSNSSLILRPLTKEAHG 482
+ VG + + C +GDP P + W K G L+G N SL +R ++ G
Sbjct: 2943 FSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAG 3002
Query: 483 HWECSASNAVARVATSTNVYVLGTSP 508
++C A N + VA + VL ++P
Sbjct: 3003 RYQCLAENEMG-VAKKVVILVLQSAP 3027
Score = 125 bits (314), Expect = 2e-28
Identities = 135/495 (27%), Positives = 194/495 (39%), Gaps = 53/495 (10%)
Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLP--IFIQFGLYSPRIDPDYVGRVR 86
VVG A +VL C + P I W R G +L QF
Sbjct: 2309 VVGLAPGQLVLECSV----EAEPAPKITWHRDGIVLQEDAHTQFP--------------- 2349
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWV--HLTVNSPPQFQETPPA 144
++G LQ++ L D G Y C + A + V + +++ P + PPA
Sbjct: 2350 -ERGRFLQLQALSTADSGDYSCTA---------RNAAGSTSVAFRVEIHTVPTIRSGPPA 2399
Query: 145 VLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSGV 203
V V + L C A G P P V+W+ L + ++ G+LRI+ V +G
Sbjct: 2400 V-NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 2458
Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
Y C AS++ GS L VL PP I P N T+ A L C A P L W
Sbjct: 2459 YLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKD 2518
Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN--GLLHPPSASAYLTVLY 321
F + Q R+L +L L A P D+ + CV SN G H +TV
Sbjct: 2519 GQKLDFRLQ--QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAH---RLYQVTVHV 2573
Query: 322 PAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 381
P + + + + P V+ C P VSW+K G L + G+ G+L
Sbjct: 2574 PPTIADDQTDFTVTMMAPVVLTCH-STGIPAPTVSWSKAGAQLGA-RGSGYRVSPSGALE 2631
Query: 382 IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG-RELLIPC 440
I G Y+C+ NS G A V L + + +P + V E+L+PC
Sbjct: 2632 IGQALPIHAGRYTCSARNSAGVAH----KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPC 2687
Query: 441 SAQGDPPPVVSWTKVGRGLQG--QAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATS 498
A G P P ++W K G + QV L + + E G++ C A N+
Sbjct: 2688 EASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK 2747
Query: 499 TNVYVLGTSPHVVTN 513
T + V P V+ N
Sbjct: 2748 TRLVV--QVPPVIEN 2760
Score = 117 bits (292), Expect = 8e-26
Identities = 148/507 (29%), Positives = 214/507 (42%), Gaps = 67/507 (13%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ-KGAS 92
G+ V L C+ G+PP V WL+ G SP + D +R G S
Sbjct: 1950 GQEVRLDCEA---DGQPPPDVA-WLKDG------------SP-LGQDMGPHLRFYLDGGS 1992
Query: 93 LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPA--VLEVQE 150
L ++GLR D G Y C H P + A V++ V PP ++ L +
Sbjct: 1993 LVLKGLRASDAGAYTCVA-----HNPAGEDARLHTVNVLV--PPTIKQGADGSGTLVSRP 2045
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERGSSGVYTCQAS 209
E VT+ C RGSP HV+W G L Q + +G TLRI +V+ +G++TC A+
Sbjct: 2046 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 2105
Query: 210 STEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
S G A L V PPV+ V + V V L C A P L SW +D
Sbjct: 2106 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLV-SWMKDGEP 2164
Query: 268 VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQV-- 325
+ S Q SL+L A D+G Y+CV + LTV+ P +
Sbjct: 2165 LLSQSLEQ-------GPSLQLEAVGAGDSGTYSCVAVSE-AGEARRHFQLTVMEPPHIED 2216
Query: 326 TAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALG 385
+ P E L G P + C + P ++W KDG+A L + S+ T L
Sbjct: 2217 SGQPTELSLTPGAPMELLCDAQGTPQ-PNITWHKDGQA--LTRLENNSRATR-----VLR 2268
Query: 386 NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG---RELLIPCSA 442
DA G Y+C + G S RV ++APP + P+ F VG +L++ CS
Sbjct: 2269 VRDA-GLYTCLAESPAGAIEKS--FRVRVQAPPNIV-GPRGPRF-VVGLAPGQLVLECSV 2323
Query: 443 QGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVARVATST 499
+ +P P ++W + G LQ A + L L+ L+ G + C+A NA + +
Sbjct: 2324 EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAF 2383
Query: 500 NVYVLGTSPHVVTNVSVVALPKGANVS 526
V + H V + + P NVS
Sbjct: 2384 RVEI-----HTVPTIR--SGPPAVNVS 2403
Score = 115 bits (288), Expect = 2e-25
Identities = 140/494 (28%), Positives = 196/494 (39%), Gaps = 39/494 (7%)
Query: 28 SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRL 87
+V G AG+S+ L CD A P+ I WL+ L+ + + + Y + VG RL
Sbjct: 27 NVSGMAGQSLTLECD----ANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 82
Query: 88 -QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVL 146
+G SL ++ D G Y CR + DF HL V +PP A
Sbjct: 83 LDEGQSLHFPRIQEGDSGLYSCRA-ENQAGTAQRDF------HLLVLTPPSVLGA-GAAQ 134
Query: 147 EVQEL--EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSG 202
EV L V L+C G P P V W + + G +QVQ LRI G G
Sbjct: 135 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 194
Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQD--VSLACHAEAYPA-NLTY 259
Y C A S G QL V PP I + V +D V L C A P N+T
Sbjct: 195 RYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT- 253
Query: 260 SWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTV 319
WF+D + +++ V L+L Q DAG YTC SN + A+ L V
Sbjct: 254 -WFKDGALLPTSTKV---VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATR-LDV 308
Query: 320 LYPAQVT---AMPPETPLPIGMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQG 375
P + P G P + C R +P P L SW +G L + +
Sbjct: 309 YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEG--LPVAESNESRLE 364
Query: 376 TEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGR 434
T+GS++ + E + G YSC + G A V + P + + VG+
Sbjct: 365 TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV-PPQLLVAEGLGQVTTIVGQ 423
Query: 435 ELLIPCSAQGDPPPVVSWTKVGR---GLQGQAQVDSNSSLILRPLTKEAHGHWECSASNA 491
L +PC A G P P + W + GR L G ++L + + + G + C A+N
Sbjct: 424 PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNE 483
Query: 492 VARVATSTNVYVLG 505
V V G
Sbjct: 484 AGTAGAEVEVSVHG 497
Score = 113 bits (283), Expect = 9e-25
Identities = 123/451 (27%), Positives = 183/451 (40%), Gaps = 53/451 (11%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ------- 139
L +G LQI+ +V D G Y C + +D ++ + PP FQ
Sbjct: 1407 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD-------FNVLIQVPPMFQKVGDFSA 1459
Query: 140 ---------ETPPAVLEVQEL---EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
E V E +E+ P L C P P +TW + L G +Q
Sbjct: 1460 AFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ 1519
Query: 188 NG-TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPP----KNSTVNASQ 242
G L+I V ++G Y+C+AS+ G +LLVL PPVI+ + TVNAS
Sbjct: 1520 GGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS 1579
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTC 301
VSL C A P T SW Q+ + PR+++L DG L++ + DA Y C
Sbjct: 1580 TVSLQCPALGNPVP-TISWLQNGLPF----SPSPRLQVLEDGQVLQVSTAEVADAASYMC 1634
Query: 302 VPSNGLLHPPSASAYLT--VLYPAQVTAMPPETPLPIGMPGV-IRCPVRANPPLLFVSWT 358
V N SA T V P ++ + E I V + C V A+P V+W
Sbjct: 1635 VAEN---QAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPN-PEVTWY 1690
Query: 359 KDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPP 418
KD +AL L + GT +L + G Y+C N+ G + ++ + PP
Sbjct: 1691 KDSQALSLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALNAAGR--DQKLVQLSVLVPP 1747
Query: 419 AFIERPK---EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLI 472
AF + P+ + VG + ++ C P P V+W K G+ L Q + L
Sbjct: 1748 AFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLE 1807
Query: 473 LRPLTKEAHGHWECSASNAVARVATSTNVYV 503
++ G + C SN + + V
Sbjct: 1808 IQEAQVSDKGLYSCKVSNVAGEAVRTFTLTV 1838
Score = 113 bits (283), Expect = 9e-25
Identities = 119/486 (24%), Positives = 187/486 (38%), Gaps = 46/486 (9%)
Query: 24 PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83
P VV V A E V+L C+ A P I W + G + +
Sbjct: 2672 PSVVRAV--AEEEVLLPCE----ASGIPRPTITWQKEGLNVATGVS-------------- 2711
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETP 142
++ G L+I ED G Y C I ++ + L V PP +
Sbjct: 2712 -TQVLPGGQLRIAHASPEDAGNYLC--------IAKNSAGSAMGKTRLVVQVPPVIENGL 2762
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSS 201
P L E L C ARGSP P++TW G+ + +G+ +Q +G L ++ +E +
Sbjct: 2763 PD-LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDA 2821
Query: 202 GVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSW 261
G YTC A + G A L +L PV P + ++ + L C A P
Sbjct: 2822 GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 2881
Query: 262 FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLY 321
D +S +L+ A +D+G Y C N + + S
Sbjct: 2882 VNDRPVTEGVSEQDG------GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEA 2935
Query: 322 PAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 381
P P+G + C VR +P + + W KDG L+ Q GSL
Sbjct: 2936 PVLQGEAFSYLVEPVGGSIQLDCVVRGDP-VPDIHWIKDGLPLRGSHLRHQLQN--GSLT 2992
Query: 382 IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCS 441
I D G Y C N +G A V ++L++ P F P++ + G ++ + C
Sbjct: 2993 IRRTERDDAGRYQCLAENEMGVA--KKVVILVLQSAPVFQVEPQDMTVRS-GDDVALRCQ 3049
Query: 442 AQGDPPPVVSWTKVGRGLQGQAQVDS--NSSLILRPLTKEAHGHWECSASNAVARVATST 499
A G+P P + W + G+ L+ ++ + + SL L + G ++C A N +
Sbjct: 3050 ATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARA 3109
Query: 500 NVYVLG 505
+ V G
Sbjct: 3110 FLVVRG 3115
Score = 109 bits (273), Expect = 1e-23
Identities = 142/499 (28%), Positives = 196/499 (39%), Gaps = 62/499 (12%)
Query: 26 VVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRV 85
V V A +V L C PA P+ I WL+ G LP SPR+
Sbjct: 1570 VEEVTVNASSTVSLQC----PALGNPVPTISWLQNG--LPFSP-----SPRLQV------ 1612
Query: 86 RLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-LTVNSPPQFQ----E 140
L+ G LQ+ V D Y C + E+ + + L V PP+ E
Sbjct: 1613 -LEDGQVLQVSTAEVADAASYMC--------VAENQAGSAEKLFTLRVQVPPRIAGLDLE 1663
Query: 141 TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT--LRIRRVER 198
A+L V+L C P P VTW + L G+ +V + GT L++ R
Sbjct: 1664 QVTAILN----SSVSLPCDVHAHPNPEVTWYKDSQALSLGE-EVFLLPGTHTLQLGRARL 1718
Query: 199 GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNS----TVNASQDVSLACHAEAYP 254
SG+YTC+A + G QL VL PP P+ V L+C +A P
Sbjct: 1719 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 1778
Query: 255 ANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSA 313
T +W++D + L R + L G L + Q D G Y+C SN +
Sbjct: 1779 -EPTVTWYKDGQPLV----LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSN-VAGEAVR 1832
Query: 314 SAYLTVLYPAQVTAMPPETPLPI-GMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG- 371
+ LTV P ET + G P V+ C V + P V+W KD ++ G
Sbjct: 1833 TFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAPTVTWLKDRMPVESSAVHGV 1891
Query: 372 WSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQE 431
S+G G L ++ G Y+C N+ A V VL+ AP E+
Sbjct: 1892 VSRG--GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLV-APRIRSSGVAREHHVL 1948
Query: 432 VGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD------SNSSLILRPLTKEAHGHWE 485
G+E+ + C A G PPP V+W K G L GQ SL+L+ L G +
Sbjct: 1949 EGQEVRLDCEADGQPPPDVAWLKDGSPL-GQDMGPHLRFYLDGGSLVLKGLRASDAGAYT 2007
Query: 486 CSASNAVARVATSTNVYVL 504
C A N A V VL
Sbjct: 2008 CVAHNPAGEDARLHTVNVL 2026
Score = 107 bits (266), Expect = 9e-23
Identities = 122/435 (28%), Positives = 181/435 (41%), Gaps = 45/435 (10%)
Query: 91 ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQE 150
A LQ++ V D G Y C H E + WV P F L V+E
Sbjct: 842 ALLQVDRADVWDAGHYTCEALNQAGH-SEKHYNLNVWV------APVFPLRESHTLTVRE 894
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDL-GQGQG--QVQVQNGTLRIRRVERGSSGVYTCQ 207
P L C RG P P ++W+ G+ L G+G G V L + + + G YTC+
Sbjct: 895 GHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 954
Query: 208 ASSTEGSATHATQLLVLGPPVIVVPPKNST-VNASQD--VSLACHAEAYPANLTYSWFQD 264
S+ G+++ QL V PP I P + T V+ QD +L C+A P T +W +D
Sbjct: 955 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP-TVTWERD 1013
Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQ 324
V LQ + + SL + Q G Y+CV N L L+VL P +
Sbjct: 1014 GQPVGAELGLQLQNQ---GQSLHVERAQAAHTGRYSCVAEN-LAGRAERKFELSVLVPPE 1069
Query: 325 VTA-MPPETPLPIGM--PGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 381
+ + P T + + P + C PP + W + + + PG E + +
Sbjct: 1070 LIGDLDPLTNITAALHSPLTLLCEAMGIPPPA-IRWFRGEEPVS----PG-----EDTYL 1119
Query: 382 IALG--------NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV- 432
+A G E G YSC N G A + VL+ PP+ EE + +
Sbjct: 1120 LAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLD 1177
Query: 433 GRELLIPCSAQGDPPPVVSWTKVGRGL-QGQAQVDSNSSLILRPL--TKEAHGHWECSAS 489
G+ + C+ G P P ++W K GR L +G A S ++L+ L + GH+ C A+
Sbjct: 1178 GQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAA 1237
Query: 490 NAVARVATSTNVYVL 504
NAV + VL
Sbjct: 1238 NAVGEKTKHFQLSVL 1252
Score = 106 bits (264), Expect = 1e-22
Identities = 148/558 (26%), Positives = 225/558 (40%), Gaps = 61/558 (10%)
Query: 88 QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQ-FQETPPAVL 146
+ G L+I G V D+G Y+C V F DF L V++PP + +
Sbjct: 178 EDGQVLRITGSHVGDEGRYQC-VAFSPAGQQARDF------QLRVHAPPTIWGSNETGEV 230
Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSSGVYT 205
V E V L C ARG P P++TW G L V + G L++ R + +GVYT
Sbjct: 231 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 290
Query: 206 CQASSTEGSATHATQLLVLGPPVIVVP---PKNSTVNASQDVSLACHAEAYPANLTYSWF 262
C+AS+ G+A AT+L V PP I P A + V+L C A +P+ T SW
Sbjct: 291 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP-TLSWH 349
Query: 263 QDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLY 321
+ + V + R+ DGS LRL + +G Y+CV S+ P+ A L
Sbjct: 350 HEGLPVAESN----ESRLETDGSVLRLESPGEASSGLYSCVASS-----PAGEAVLQYSV 400
Query: 322 PAQVTAMPPETPLPIGMPGV-------IRCPVRAN-PPLLFVSWTKDGK-ALQLDKFPGW 372
QV PP+ + G+ V + P +A+ P+ + W ++G+ A +L
Sbjct: 401 EVQV---PPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVA 457
Query: 373 SQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV 432
SQGT +L I D G ++C N GTAG V + P +E P +Y
Sbjct: 458 SQGT--TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGX 515
Query: 433 GRELLIPCS----------AQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA-- 480
P + A PP V W G L G+ + + PL E
Sbjct: 516 EHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSLPPPLQIEKVD 574
Query: 481 ---HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQ 537
G + C+A+N + VL P++ A+ + A+V+ E G
Sbjct: 575 LRDEGIYTCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECLASGVPPP 633
Query: 538 RFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS- 596
S W+ + + W+ + V V L + Q + +A N GS
Sbjct: 634 DVS-WF-----KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 687
Query: 597 EIVLSAPEGLPTTPAAPG 614
+ ++ P + P+ PG
Sbjct: 688 GLRVNVPPRITLPPSLPG 705
Score = 106 bits (264), Expect = 1e-22
Identities = 112/431 (25%), Positives = 174/431 (40%), Gaps = 33/431 (7%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ--ETPPAVLE 147
G L + ++ +G Y C + + +D + L V+ PPQ PP +
Sbjct: 935 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQD-------LQLEVHVPPQIAGPREPPTQVS 987
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTC 206
V + TL C A G P P VTW+ G+ +G G Q+Q Q +L + R + +G Y+C
Sbjct: 988 VVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 1047
Query: 207 QASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
A + G A +L VL PP ++ P N T ++L C A P WF+
Sbjct: 1048 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP-AIRWFR 1106
Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPA 323
V S + + L++ TQ D+G Y+C+ SN + + VL P
Sbjct: 1107 GEEPV---SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNE-AGEARRNFSVEVLVPP 1162
Query: 324 QVTAMPPETPLPI--GMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSL 380
+ E + + G + C V +P P L +W KDG+ L + +G L
Sbjct: 1163 SIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFKDGRPLA--RGDAHHISPDGVL 1218
Query: 381 IIAL-GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF---IERPKEEYFQEVGREL 436
+ L N + G YSC N++G VLL AP + EE V +
Sbjct: 1219 LQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLL-APTILGGAEDSADEEVTVTVNNPI 1277
Query: 437 LIPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNAVA 493
+ C A P P ++W K G + + L + KE G + C +N +
Sbjct: 1278 SLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1337
Query: 494 RVATSTNVYVL 504
+ +V VL
Sbjct: 1338 EAVKNYHVEVL 1348
Score = 102 bits (253), Expect = 3e-21
Identities = 133/525 (25%), Positives = 206/525 (39%), Gaps = 77/525 (14%)
Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPP--AGRPPLHVIEWLRFGFLLPIFIQF 70
V+ + + P+++ G + ++G L P A P+ I+WL+ G
Sbjct: 395 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--------- 445
Query: 71 GLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHL 130
R + G +G +L I+ + ++ G + C+ + G+ V +
Sbjct: 446 -----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA-------TNEAGTAGAEVEV 493
Query: 131 TVNSPPQFQETPPAVLEV---------QELEPVTLRC---VARG---SPLPHVT--WKLR 173
+V+ E P VLEV + C V RG P P + W
Sbjct: 494 SVHG-----EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSP 548
Query: 174 GKDLGQGQGQVQVQN--GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVV 231
G G+ G + L+I +V+ G+YTC A++ G + L VL PP I
Sbjct: 549 GSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP 608
Query: 232 PPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLA 290
P N V + V+L C A P SWF+ + V V + VDG LR+
Sbjct: 609 GPVNKAVLENASVTLECLASGVPPP-DVSWFKGHQPV----SSWMGVTVSVDGRVLRIEQ 663
Query: 291 TQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPG--VIRCPVR- 347
Q DAG Y CV SN + + Y +V +PP LP +PG ++ PVR
Sbjct: 664 AQLSDAGSYRCVASN-------VAGSTELRYGLRVN-VPPRITLPPSLPGPVLVNTPVRL 715
Query: 348 ----ANPPLLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLG 402
P + W KDG + PG G L +A G YSC +++G
Sbjct: 716 TCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG 775
Query: 403 TAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE-LLIPCSAQGDPPPVVSWTKVGRGLQG 461
V +V + PP+ + +E V E + + C + PPPV+SW K GR L+
Sbjct: 776 EDRQDVVLQVHM--PPSIL--GEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEP 831
Query: 462 QAQVDSNSSLILRPLTKE---AHGHWECSASNAVARVATSTNVYV 503
+ V ++ L + + GH+ C A N N+ V
Sbjct: 832 RPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV 876
Score = 100 bits (248), Expect = 1e-20
Identities = 116/434 (26%), Positives = 168/434 (38%), Gaps = 43/434 (9%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH--LTVNSPPQFQETPPAVLE 147
G L+IE ++ D G Y C + A + + L VN PP+ P
Sbjct: 656 GRVLRIEQAQLSDAGSYRCVA---------SNVAGSTELRYGLRVNVPPRITLPPSLPGP 706
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQVQNG--TLRIRRVERGSSGVY 204
V PV L C A G+P P + W G + G +QV G L + SG Y
Sbjct: 707 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 766
Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
+C A S G L V PP I+ N +V A++ V+L C + A P + SW++D
Sbjct: 767 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKD 825
Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPD---DAGCYTCVPSNGLLHPPSASAYLTVLY 321
L+PR + + LL DAG YTC N H S Y ++
Sbjct: 826 G------RPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGH--SEKHYNLNVW 877
Query: 322 PAQVTAMPPETPLPI--GMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG- 378
A V + L + G P + C R P +SW KDG+ L PG G +
Sbjct: 878 VAPVFPLRESHTLTVREGHPTRLSCECR-GVPFPKISWRKDGQPL-----PGEGAGLQHV 931
Query: 379 ---SLIIALGNEDAL--GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG 433
++ LG G Y+C N +G + V + A P +
Sbjct: 932 SAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQD 991
Query: 434 RELLIPCSAQGDPPPVVSWTKVGR--GLQGQAQVDSNSSLILRPLTKEAH-GHWECSASN 490
+ C+A G PPP V+W + G+ G + Q+ + + + AH G + C A N
Sbjct: 992 GVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN 1051
Query: 491 AVARVATSTNVYVL 504
R + VL
Sbjct: 1052 LAGRAERKFELSVL 1065
Score = 96.7 bits (239), Expect = 1e-19
Identities = 128/513 (24%), Positives = 196/513 (38%), Gaps = 67/513 (13%)
Query: 16 QGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSP 75
Q A R P VSVV L C+ G+PP + W R G P+ + GL
Sbjct: 975 QIAGPREPPTQVSVVQDG--VATLECNA---TGKPP-PTVTWERDG--QPVGAELGL--- 1023
Query: 76 RIDPDYVGRVRLQ-KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNS 134
+LQ +G SL +E + G Y C L L+V
Sbjct: 1024 ----------QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK-------FELSVLV 1066
Query: 135 PPQF--QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TL 191
PP+ P + P+TL C A G P P + W + + G+ + G L
Sbjct: 1067 PPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWML 1126
Query: 192 RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA--SQDVSLACH 249
++ + + SG+Y+C AS+ G A + VL PP I + Q L C+
Sbjct: 1127 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 1186
Query: 250 AEAYPANLTYSWFQDNI-----NVFHISRLQPRVRILVDGSL-RLLATQPDDAGCYTCVP 303
+P +WF+D + HIS DG L ++L AG Y+C+
Sbjct: 1187 VTGHPQP-KLTWFKDGRPLARGDAHHISP---------DGVLLQVLQANLSSAGHYSCIA 1236
Query: 304 SNGLLHPPSASAYLTVLYPAQV----TAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTK 359
+N + +L P + + E + + P + C A P ++W K
Sbjct: 1237 ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPN-ITWMK 1295
Query: 360 DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 419
DG + + GT G I+ EDA G+Y+C N LG A + VL+ PP+
Sbjct: 1296 DGAPFEASRNIQLLPGTHGLQILNAQKEDA-GQYTCVVTNELGEAVKNYHVEVLI--PPS 1352
Query: 420 F------IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSL 471
E +E +V L + C + PPP + W K G+ + + QV L
Sbjct: 1353 ISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL 1412
Query: 472 I-LRPLTKEAHGHWECSASNAVARVATSTNVYV 503
+ ++P G + C A+N NV +
Sbjct: 1413 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 1445
Score = 63.9 bits (154), Expect = 8e-10
Identities = 48/145 (33%), Positives = 68/145 (46%), Gaps = 11/145 (7%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTV-NSPPQFQETP 142
R +LQ G SL I +D G Y+C + E++ V + V S P FQ
Sbjct: 2983 RHQLQNG-SLTIRRTERDDAGRYQC--------LAENEMGVAKKVVILVLQSAPVFQ-VE 3032
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202
P + V+ + V LRC A G P P + W G+ L + + +G+L + VE G +G
Sbjct: 3033 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 3092
Query: 203 VYTCQASSTEGSATHATQLLVLGPP 227
Y C A + GSAT L+V G P
Sbjct: 3093 TYDCVAHNLLGSATARAFLVVRGEP 3117
Score = 60.1 bits (144), Expect = 1e-08
Identities = 98/443 (22%), Positives = 162/443 (36%), Gaps = 64/443 (14%)
Query: 93 LQIEGLRVEDQGWYECRVFF-LDQHIPEDDFANGSWVHLTVNSPPQFQETPP-AVLEVQE 150
LQI + ED G Y C V L + + H+ V PP + P A + V+E
Sbjct: 1315 LQILNAQKEDAGQYTCVVTNELGEAVKN--------YHVEVLIPPSISKDDPLAEVGVKE 1366
Query: 151 LEP-----VTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVY 204
++ +TL C + P P + W G+ + QV + L+I+ + SG Y
Sbjct: 1367 VKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRY 1426
Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNST--------------------VNASQDV 244
C A++ G +L+ PP+ S + +
Sbjct: 1427 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 1486
Query: 245 SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVP 303
L C A P +W++++ + V +L G L++ + ++AG Y+C
Sbjct: 1487 YLYCDTNAIPPP-DLTWYREDQPL----SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKA 1541
Query: 304 SNGL----LHPPSASAYLTVLYPAQVTA----MPPETPLPIGMPGVIRCPVRANPPLLFV 355
SN + LH L VL P + + E + ++CP N P+ +
Sbjct: 1542 SNEVGEDWLH-----YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN-PVPTI 1595
Query: 356 SWTKDGKALQLDKFPGWSQGTEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLL 414
SW ++G L P +G ++ ++ Y C N G+A RV
Sbjct: 1596 SWLQNG--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV-- 1651
Query: 415 KAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSL 471
+ PP E+ + + +PC P P V+W K + L +V +L
Sbjct: 1652 QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTL 1711
Query: 472 ILRPLTKEAHGHWECSASNAVAR 494
L G + C A NA R
Sbjct: 1712 QLGRARLSDSGMYTCEALNAAGR 1734
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 126 bits (317), Expect = 1e-28
Identities = 149/576 (25%), Positives = 230/576 (39%), Gaps = 64/576 (11%)
Query: 155 TLRCVARGSPLPH--VTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTE 212
TL C+A P+ VTWK G + G + L I +G Y C+A+
Sbjct: 312 TLECIASARPVEDLSVTWKRNGVRITSG---LHSFGRRLTISNPTSADTGPYVCEAA-LP 367
Query: 213 GSATHATQ----LLVLGPPVIVVPPKNS-TVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
GSA + L ++ PP P++ + + V + C A P T W++D I+
Sbjct: 368 GSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLP-TLQWYKDAIS 426
Query: 268 VFHISRLQ-PRVRILVDGSLRLLATQPDDAGCYTCVPSN--GLLHPPSASAYLTVLYPAQ 324
ISRLQ PR ++L G LR+ +P+D+G + C SN G + YL V A
Sbjct: 427 ---ISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEI---QTHTYLDVTNIAP 480
Query: 325 V-TAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLD--KFPGWSQGTEGSLI 381
V T P +T + GM ++RC V + P ++W ++ L + P + G L
Sbjct: 481 VFTQRPVDTTVTDGMTAILRCEV-SGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQ 539
Query: 382 IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCS 441
IA G Y+C N+ G+ S V + I P E++ G + C
Sbjct: 540 IAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTS---IVHPPEDHVVIKGTTATLHCG 596
Query: 442 AQGDPPPVVS--WTKVGRGL----QGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARV 495
A DP + W K L + V+ + SL++ G + C +
Sbjct: 597 ATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGND 656
Query: 496 ATSTNVYVLGTSPHVVTNVSVVALPKGAN---VSWEPGFDGGYLQRFSVWYTPLAKRPDR 552
+ + V+ PH N+ V ++ +SW FDG + + P +
Sbjct: 657 SRMARLEVI-ELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWK 715
Query: 553 MHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV--LSAPEGLPTTP 610
+H V + + V GL P YQF V A N++G G +S L PE
Sbjct: 716 VHLSNVGPEM----TGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPE------ 765
Query: 611 AAPGLPPTEIPPPLSPPRGLVAV-RTPRGVLLHWDPPELVPKR--LDGYVLEGRQGSQGW 667
PP +PP+ +VA RT + +++ W PP L GY+L R
Sbjct: 766 ----------EPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPG 815
Query: 668 EVLDPAVAGTETE-LLVPGLIKDVLYEFRLVAFAGS 702
E + E LV LI YE ++ A+ G+
Sbjct: 816 EYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGA 851
Score = 96.3 bits (238), Expect = 2e-19
Identities = 136/555 (24%), Positives = 206/555 (37%), Gaps = 60/555 (10%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANG-SWVHLTVNSPPQFQETPPAVLEV 148
G L I D G Y C + +P F + L + PP F P + +
Sbjct: 344 GRRLTISNPTSADTGPYVC-----EAALPGSAFEPARATAFLFIIEPPYFTAEPESRISA 398
Query: 149 QELEPVTLRCVARGSPLPHVTWKLRGKDLG--QGQGQVQVQNGTLRIRRVERGSSGVYTC 206
+ E V + C A G PLP + W + Q + +G LRI+++ SG++ C
Sbjct: 399 EVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQC 458
Query: 207 QASSTEGSATHATQLLVLG-PPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDN 265
AS+ G T L V PV P ++TV L C P +W ++N
Sbjct: 459 FASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAP-KPAITWKREN 517
Query: 266 INVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN--GLLHPPSASAYLTVLYPA 323
+ S PR +L G L++ DAG YTC +N G L +ASA LTV
Sbjct: 518 HILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSL---NASATLTVWNRT 574
Query: 324 QVTAMPPETPLPIGMPGVIRCPVRANPPL-LFVSWTKDGKALQLDKFPGWSQGTEGSLII 382
+ P + + G + C +P + L W KD AL +GSL+I
Sbjct: 575 SIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLI 634
Query: 383 ALGNEDALGEYSCTPYNSLGTAGPSPVTRV--LLKAPPAFIERPKEEYFQEVGRELLIPC 440
+ +G+YSC + G V L +P + P + V + P
Sbjct: 635 SQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPF 694
Query: 441 S------------AQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSA 488
++ + P V + VG + G + + LT + A
Sbjct: 695 DGNSPILYYIVELSENNSPWKVHLSNVGPEMTG---------VTVSGLTPARTYQFRVCA 745
Query: 489 SNAVAR--VATSTNVYVLGTSPHVVTNVSVVA---LPKGANVSWEP-------GFDGGYL 536
N V R + T+ +L P ++VA + V W+P G GY+
Sbjct: 746 VNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYI 805
Query: 537 QRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS 596
R+ + P + + V+ + LV L TQY+ V A N G G FS
Sbjct: 806 LRYRLAGLPGEYQQRNITSPEVN--------YCLVTDLIIWTQYEIQVAAYNGAGLGVFS 857
Query: 597 EIVLS-APEGLPTTP 610
V +G+PT P
Sbjct: 858 RAVTEYTLQGVPTAP 872
Score = 85.5 bits (210), Expect = 3e-16
Identities = 76/272 (27%), Positives = 116/272 (42%), Gaps = 31/272 (11%)
Query: 35 ESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQ 94
E+V +GC + PL ++W + + L +PR G +R+QK
Sbjct: 402 ETVDIGCQAMGV----PLPTLQWYKDAISIS-----RLQNPRYKVLASGGLRIQK----- 447
Query: 95 IEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPV 154
LR ED G ++C I + + N P F + P + +
Sbjct: 448 ---LRPEDSGIFQCFASNEGGEIQTHTYLD------VTNIAPVFTQRPVDTTVTDGMTAI 498
Query: 155 TLRCVARGSPLPHVTWKLRGKDLGQGQGQVQ----VQNGTLRIRRVERGSSGVYTCQASS 210
LRC G+P P +TWK L G ++ +++G L+I V +G YTC A++
Sbjct: 499 -LRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAAN 557
Query: 211 TEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYP-ANLTYSWFQDNINVF 269
TEGS + L V IV PP++ V +L C A P +L Y W +DN+ +
Sbjct: 558 TEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALT 617
Query: 270 HISRLQPRVRILVDGSLRLLATQPDDAGCYTC 301
S R+ + DGSL + T D G Y+C
Sbjct: 618 PSS--TSRIVVEKDGSLLISQTWSGDIGDYSC 647
Score = 70.5 bits (171), Expect = 9e-12
Identities = 90/391 (23%), Positives = 144/391 (36%), Gaps = 43/391 (10%)
Query: 164 PLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLV 223
P P VTW G + L I +G Y QA + + + +
Sbjct: 219 PRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIH 278
Query: 224 LG-----------PPVIVVPPKN-STVNASQDVSLACHAEAYPA-NLTYSWFQDNINVFH 270
L P IVVPP N S V S + +L C A A P +L+ +W ++ + +
Sbjct: 279 LSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRI-- 336
Query: 271 ISRLQPRVRILVDGSLRLLATQPD--DAGCYTCVPS--NGLLHPPSASAYLTVLYPAQVT 326
S L R RL + P D G Y C + P A+A+L ++ P T
Sbjct: 337 TSGLHSFGR-------RLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFT 389
Query: 327 AMPPETPLPIGMPGVIRCPVRA-NPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALG 385
A PE+ + + + +A PL + W KD ++ + P + G L I
Sbjct: 390 A-EPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKL 448
Query: 386 NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGD 445
+ G + C N G V P F +RP + + G ++ C G
Sbjct: 449 RPEDSGIFQCFASNEGGEIQTHTYLDV-TNIAPVFTQRPVDTTVTD-GMTAILRCEVSGA 506
Query: 446 PPPVVSWTKVGRGL-QGQAQVD-----SNSSLILRPLTKEAHGHWECSASNAVARVATST 499
P P ++W + L G ++ + L + P+ + G++ C A+N + S
Sbjct: 507 PKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASA 566
Query: 500 NVYVLGTS-------PHVVTNVSVVALPKGA 523
+ V + HVV + L GA
Sbjct: 567 TLTVWNRTSIVHPPEDHVVIKGTTATLHCGA 597
Score = 46.2 bits (108), Expect = 2e-04
Identities = 58/205 (28%), Positives = 82/205 (40%), Gaps = 31/205 (15%)
Query: 524 NVSW-EPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAH-----LLVPGLQPH 577
NVSW EP G LQ + V Y PLA VS V V L V L
Sbjct: 1819 NVSWGEPAAANGILQGYRVVYEPLAPVQG------VSKVVTVEVRGNWQRWLKVRDLTKG 1872
Query: 578 TQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPR 637
Y F V A+ + GP + ++A P E P PR ++ ++
Sbjct: 1873 VTYFFRVQART-ITYGPELQANITAG-------------PAEGSP--GSPRDVLVTKSAS 1916
Query: 638 GVLLHWDPPELVPKRLDGYVLEGRQGSQG-WE--VLDPAVAGTETELLVPGLIKDVLYEF 694
+ L W GYV+E R +G W+ V D + T L + L + V YEF
Sbjct: 1917 ELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEF 1976
Query: 695 RLVAFAGSFVSDPSNTANVSTSGLE 719
R+VA + +PSN + ++ +E
Sbjct: 1977 RVVAVNEAGYGEPSNPSTAVSAQVE 2001
Score = 45.8 bits (107), Expect = 2e-04
Identities = 44/164 (26%), Positives = 64/164 (39%), Gaps = 24/164 (14%)
Query: 521 KGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY 580
+ + W PG DG R+ +T + R S ++ A +V L+P T Y
Sbjct: 1493 RSLRLQWVPGSDGASPIRY---FTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSY 1549
Query: 581 QFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVL 640
+ + A N +G FS S E + T PG PP + T VL
Sbjct: 1550 KLRLKATNDIGDSDFS----SETEAVTTLQDVPGEPPGSVS---------ATPHTTSSVL 1596
Query: 641 LHWDPP--ELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTETELL 682
+ W PP E + L GY + R E+ A +GTE + L
Sbjct: 1597 IQWQPPRDESLNGLLQGYRIYYR------ELEYEAGSGTEAKTL 1634
Score = 45.1 bits (105), Expect = 4e-04
Identities = 48/202 (23%), Positives = 78/202 (38%), Gaps = 35/202 (17%)
Query: 510 VVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVG---A 566
V++N+S P+ A + + PG+DG S W +WV+L A
Sbjct: 1077 VISNIS----PRSATLQFRPGYDGK--TSISRWIVEGQVGAIGDEEEWVTLYEEENEPDA 1130
Query: 567 AHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSP 626
L +P L P+T Y+F + N +G P+S P++ + + PP ++P
Sbjct: 1131 QMLEIPNLTPYTHYRFRMKQVNIVGPSPYS-------------PSSRVIQTLQAPPDVAP 1177
Query: 627 PRGLVAVRTPRGVLLHWDP---------PELVPKRLDGYVLEGRQGSQGWEVLDPAVAGT 677
V + + L W P PE V R+ + R Q V
Sbjct: 1178 TSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYW----RSDLQSSAVAQVVSDRL 1233
Query: 678 ETELLVPGLIKDVLYEFRLVAF 699
E E + L + + YE ++ AF
Sbjct: 1234 EREFTIEELEEWMEYELQMQAF 1255
Score = 37.4 bits (85), Expect = 0.085
Identities = 60/222 (27%), Positives = 85/222 (38%), Gaps = 37/222 (16%)
Query: 513 NVSVVALPKGA-NVSWEPG---FDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAH 568
NV V L V+W+P G +Q + ++Y + + + L PV
Sbjct: 1707 NVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPV---- 1762
Query: 569 LLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPP----TEIPPPL 624
+ + L HT+Y S+ A N G GP S+ P+ T AAPG P +EI
Sbjct: 1763 VRLKNLTSHTKYLVSISAFNAAGDGPKSD-----PQQGRTHQAAPGAPSFLAFSEI---- 1813
Query: 625 SPPRGLVAVRTPRGVLLHWDPPELVPKRLDGY--VLEGRQGSQG-WEVLDPAVAGT-ETE 680
T + + W P L GY V E QG +V+ V G +
Sbjct: 1814 ----------TSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRW 1863
Query: 681 LLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYP 722
L V L K V Y FR+ A + P AN++ E P
Sbjct: 1864 LKVRDLTKGVTYFFRVQ--ARTITYGPELQANITAGPAEGSP 1903
Score = 36.2 bits (82), Expect = 0.19
Identities = 37/134 (27%), Positives = 56/134 (41%), Gaps = 27/134 (20%)
Query: 574 LQPHTQYQFSVLAQNKLGSGPFSEIVL-----SAPEGLPTTPAAPGLPPTEIPPPLSPPR 628
L+ +Y+ + A N +G+GP+SE+V S P P +A + T+I
Sbjct: 1242 LEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQI-------- 1293
Query: 629 GLVAVRTPRGVLLHWD--PPELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTETE-LLVPG 685
LL W P + + GY + R E V G T+ L+ G
Sbjct: 1294 -----------LLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAG 1342
Query: 686 LIKDVLYEFRLVAF 699
L K VLYE +++AF
Sbjct: 1343 LRKFVLYELQVLAF 1356
Score = 35.0 bits (79), Expect = 0.42
Identities = 40/152 (26%), Positives = 60/152 (39%), Gaps = 17/152 (11%)
Query: 570 LVPGLQPHTQYQFSVLAQNKLGSG-PFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPR 628
L+ GL+ Y+ VLA ++G+G P + ++L T APG PP + + P
Sbjct: 1339 LLAGLRKFVLYELQVLAFTRIGNGVPSTPLILER-----TKDDAPG-PPVRL---VFPEV 1389
Query: 629 GLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPA-VAGTETELLVPGLI 687
L +VR + W PPE + GY + R S V T + L
Sbjct: 1390 RLTSVR------IVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLA 1443
Query: 688 KDVLYEFRLVAFAGSFVSDPSNTANVSTSGLE 719
+ Y FRL A +P ++T E
Sbjct: 1444 PESAYIFRLSAKTRQGWGEPLEATVITTEKRE 1475
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 126 bits (316), Expect = 1e-28
Identities = 97/365 (26%), Positives = 154/365 (42%), Gaps = 19/365 (5%)
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQ--VQNGTLRIRRVERGS 200
P +V V C A G+P P + W +L + +GTL I+ +
Sbjct: 252 PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETD 311
Query: 201 SGVYTCQASSTEGSA-THATQLLVLGPPV---IVVPPKNSTVNASQDVSLACHAEAYPAN 256
G+Y C A + G T L G P V+ P+N+ V + V+L C A +P
Sbjct: 312 QGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPP 371
Query: 257 LTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAY 316
SW + + + PRV I G L + D+G Y C +N + A+A+
Sbjct: 372 -RISWTRGDRTPLPVD---PRVNITPSGGLYIQNVVQGDSGEYACSATNNI-DSVHATAF 426
Query: 317 LTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDK-FPGWSQG 375
+ V Q T P + + G +C + NPP + ++WTK G L +D+ S G
Sbjct: 427 IIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPV-IAWTKGGSQLSVDRRHLVLSSG 485
Query: 376 TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 435
T +AL ++ G+Y C N +G+ V + P F P + EVG
Sbjct: 486 TLRISGVALHDQ---GQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTV-EVGAN 541
Query: 436 LLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPLTKEAHGHWECSASNAVA 493
+ +PCS+QG+P P ++W K G + G+ + L + + G +EC A N +
Sbjct: 542 VQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIG 601
Query: 494 RVATS 498
+ S
Sbjct: 602 SASVS 606
Score = 88.2 bits (217), Expect = 4e-17
Identities = 89/335 (26%), Positives = 144/335 (42%), Gaps = 22/335 (6%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
R+ L +L I+ + DQG Y+C + + + + + + P F P
Sbjct: 293 RLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEV---TLRYFGSPARPTF-VIQP 348
Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSG 202
EV E VTL C A G P P ++W + +V + +G L I+ V +G SG
Sbjct: 349 QNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSG 408
Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWF 262
Y C A++ S ++V P V P++ V Q V C A+ P + +W
Sbjct: 409 EYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPV-IAWT 467
Query: 263 QDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYP 322
+ + + R +L G+LR+ D G Y C N ++ A+LTV
Sbjct: 468 KGGSQL----SVDRRHLVLSSGTLRISGVALHDQGQYECQAVN-IIGSQKVVAHLTV--Q 520
Query: 323 AQVT----AMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG 378
+VT ++P +T + +G + C + P ++W KDG +Q+ + + EG
Sbjct: 521 PRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPA-ITWNKDG--VQVTESGKFHISPEG 577
Query: 379 SLII-ALGNEDALGEYSCTPYNSLGTAGPSPVTRV 412
L I +G DA G Y C N++G+A S V V
Sbjct: 578 FLTINDVGPADA-GRYECVARNTIGSASVSMVLSV 611
Score = 85.5 bits (210), Expect = 3e-16
Identities = 87/296 (29%), Positives = 119/296 (40%), Gaps = 44/296 (14%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
GESV L C G PP I W R G P+ +DP RV + L
Sbjct: 356 GESVTLECSA---TGHPPPR-ISWTR-GDRTPL---------PVDP----RVNITPSGGL 397
Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
I+ + D G Y C + F + V + PQF TP + + E +
Sbjct: 398 YIQNVVQGDSGEYACSATNNIDSVHATAF-------IIVQALPQFTVTPQDRVVI-EGQT 449
Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEG 213
V +C A+G+P P + W G L + + + +GTLRI V G Y CQA + G
Sbjct: 450 VDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG 509
Query: 214 SATHATQLLVLG--PPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV--- 268
S L V PV P ++TV +V L C ++ P +W +D + V
Sbjct: 510 SQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEP-EPAITWNKDGVQVTES 568
Query: 269 --FHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYP 322
FHIS +G L + P DAG Y CV N + S S L+V P
Sbjct: 569 GKFHIS---------PEGFLTINDVGPADAGRYECVARN-TIGSASVSMVLSVNVP 614
Score = 65.9 bits (159), Expect = 2e-10
Identities = 66/302 (21%), Positives = 115/302 (38%), Gaps = 15/302 (4%)
Query: 324 QVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIA 383
++T+ P + + G C NP + W ++ L + + +G+L+I
Sbjct: 247 RITSEPQDADVTSGNTVYFTCRAEGNPKPEII-WLRNNNELSMKTDSRLNLLDDGTLMIQ 305
Query: 384 LGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAP--PAFIERPKEEYFQEVGRELLIPCS 441
E G Y C N G VT +P P F+ +P+ VG + + CS
Sbjct: 306 NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVL-VGESVTLECS 364
Query: 442 AQGDPPPVVSWTKVGRG---LQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATS 498
A G PPP +SWT+ R + + + + L ++ + + G + CSA+N + V +
Sbjct: 365 ATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHAT 424
Query: 499 TNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWV 558
+ V VT V + +G V ++ G + DR H
Sbjct: 425 AFIIVQALPQFTVTPQDRVVI-EGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRH---- 479
Query: 559 SLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPT 618
+ + + L + G+ H Q Q+ A N +GS + P P + P
Sbjct: 480 ---LVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTV 536
Query: 619 EI 620
E+
Sbjct: 537 EV 538
Score = 48.5 bits (114), Expect = 4e-05
Identities = 56/200 (28%), Positives = 82/200 (41%), Gaps = 35/200 (17%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
G++V C+ G PP VI W + G L + + + S +L
Sbjct: 447 GQTVDFQCEA---KGNPP-PVIAWTKGGSQLSVDRRHLVLS---------------SGTL 487
Query: 94 QIEGLRVEDQGWYECRVFFL--DQHIPEDDFANGSWVHLTVNS--PPQFQETPPAVLEVQ 149
+I G+ + DQG YEC+ + Q + HLTV P F P V+
Sbjct: 488 RISGVALHDQGQYECQAVNIIGSQKVV---------AHLTVQPRVTPVFASIPSDTT-VE 537
Query: 150 ELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSSGVYTCQA 208
V L C ++G P P +TW G + + G+ + G L I V +G Y C A
Sbjct: 538 VGANVQLPCSSQGEPEPAITWNKDGVQVTES-GKFHISPEGFLTINDVGPADAGRYECVA 596
Query: 209 SSTEGSATHATQLLVLGPPV 228
+T GSA+ + L V P V
Sbjct: 597 RNTIGSASVSMVLSVNVPDV 616
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 125 bits (315), Expect = 2e-28
Identities = 112/386 (29%), Positives = 166/386 (43%), Gaps = 21/386 (5%)
Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
V LTV + P + P V V E E V L C A G P P +TW+ G ++ G +
Sbjct: 2749 VFLTVQASPVVKPLPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP 2807
Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
G LRI +G Y C A ++ GSA T+L+V PPVI + + L
Sbjct: 2808 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLP 2867
Query: 248 CHAEAYP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306
C A P N+T W +D V S + + I G L + + DAG YTC N
Sbjct: 2868 CKARGSPEPNIT--WDKDGQPV---SGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENA 2922
Query: 307 LLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQL 366
+ +LT+L T +P + L +G +RC R +P + WT + + +
Sbjct: 2923 -VGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPR-IGWTVNDRPVT- 2979
Query: 367 DKFPGWSQGTEGSLI--IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERP 424
G S+ GS + A+ ED+ G Y C N +G V+ V +K P
Sbjct: 2980 ---EGVSEQDGGSTLQRAAVSREDS-GTYVCWAENRVGRT--QAVSFVHVKEAPVLQGEA 3033
Query: 425 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ--AQVDSNSSLILRPLTKEAHG 482
+ VG + + C +GDP P + W K G L+G N SL + ++ G
Sbjct: 3034 FSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAG 3093
Query: 483 HWECSASNAVARVATSTNVYVLGTSP 508
++C A N + VA + VL ++P
Sbjct: 3094 RYQCLAENEMG-VAKKVVILVLQSAP 3118
Score = 125 bits (314), Expect = 2e-28
Identities = 135/495 (27%), Positives = 194/495 (39%), Gaps = 53/495 (10%)
Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLP--IFIQFGLYSPRIDPDYVGRVR 86
VVG A +VL C + P I W R G +L QF
Sbjct: 2400 VVGLAPGQLVLECSV----EAEPAPKITWHRDGIVLQEDAHTQFP--------------- 2440
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWV--HLTVNSPPQFQETPPA 144
++G LQ++ L D G Y C + A + V + +++ P + PPA
Sbjct: 2441 -ERGRFLQLQALSTADSGDYSCTA---------RNAAGSTSVAFRVEIHTVPTIRSGPPA 2490
Query: 145 VLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSGV 203
V V + L C A G P P V+W+ L + ++ G+LRI+ V +G
Sbjct: 2491 V-NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 2549
Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
Y C AS++ GS L VL PP I P N T+ A L C A P L W
Sbjct: 2550 YLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKD 2609
Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN--GLLHPPSASAYLTVLY 321
F + Q R+L +L L A P D+ + CV SN G H +TV
Sbjct: 2610 GQKLDFRLQ--QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAH---RLYQVTVHV 2664
Query: 322 PAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 381
P + + + + P V+ C P VSW+K G L + G+ G+L
Sbjct: 2665 PPTIADDQTDFTVTMMAPVVLTCH-STGIPAPTVSWSKAGAQLGA-RGSGYRVSPSGALE 2722
Query: 382 IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG-RELLIPC 440
I G Y+C+ NS G A V L + + +P + V E+L+PC
Sbjct: 2723 IGQALPIHAGRYTCSARNSAGVAH----KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPC 2778
Query: 441 SAQGDPPPVVSWTKVGRGLQG--QAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATS 498
A G P P ++W K G + QV L + + E G++ C A N+
Sbjct: 2779 EASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK 2838
Query: 499 TNVYVLGTSPHVVTN 513
T + V P V+ N
Sbjct: 2839 TRLVV--QVPPVIEN 2851
Score = 117 bits (292), Expect = 8e-26
Identities = 148/507 (29%), Positives = 214/507 (42%), Gaps = 67/507 (13%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ-KGAS 92
G+ V L C+ G+PP V WL+ G SP + D +R G S
Sbjct: 2041 GQEVRLDCEA---DGQPPPDVA-WLKDG------------SP-LGQDMGPHLRFYLDGGS 2083
Query: 93 LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPA--VLEVQE 150
L ++GLR D G Y C H P + A V++ V PP ++ L +
Sbjct: 2084 LVLKGLRASDAGAYTCVA-----HNPAGEDARLHTVNVLV--PPTIKQGADGSGTLVSRP 2136
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERGSSGVYTCQAS 209
E VT+ C RGSP HV+W G L Q + +G TLRI +V+ +G++TC A+
Sbjct: 2137 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 2196
Query: 210 STEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
S G A L V PPV+ V + V V L C A P L SW +D
Sbjct: 2197 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLV-SWMKDGEP 2255
Query: 268 VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQV-- 325
+ S Q SL+L A D+G Y+CV + LTV+ P +
Sbjct: 2256 LLSQSLEQ-------GPSLQLEAVGAGDSGTYSCVAVSE-AGEARRHFQLTVMEPPHIED 2307
Query: 326 TAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALG 385
+ P E L G P + C + P ++W KDG+A L + S+ T L
Sbjct: 2308 SGQPTELSLTPGAPMELLCDAQGTPQ-PNITWHKDGQA--LTRLENNSRATR-----VLR 2359
Query: 386 NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG---RELLIPCSA 442
DA G Y+C + G S RV ++APP + P+ F VG +L++ CS
Sbjct: 2360 VRDA-GLYTCLAESPAGAIEKS--FRVRVQAPPNIV-GPRGPRF-VVGLAPGQLVLECSV 2414
Query: 443 QGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVARVATST 499
+ +P P ++W + G LQ A + L L+ L+ G + C+A NA + +
Sbjct: 2415 EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAF 2474
Query: 500 NVYVLGTSPHVVTNVSVVALPKGANVS 526
V + H V + + P NVS
Sbjct: 2475 RVEI-----HTVPTIR--SGPPAVNVS 2494
Score = 113 bits (283), Expect = 9e-25
Identities = 123/451 (27%), Positives = 183/451 (40%), Gaps = 53/451 (11%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ------- 139
L +G LQI+ +V D G Y C + +D ++ + PP FQ
Sbjct: 1498 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD-------FNVLIQVPPMFQKVGDFSA 1550
Query: 140 ---------ETPPAVLEVQEL---EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
E V E +E+ P L C P P +TW + L G +Q
Sbjct: 1551 AFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ 1610
Query: 188 NG-TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPP----KNSTVNASQ 242
G L+I V ++G Y+C+AS+ G +LLVL PPVI+ + TVNAS
Sbjct: 1611 GGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS 1670
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTC 301
VSL C A P T SW Q+ + PR+++L DG L++ + DA Y C
Sbjct: 1671 TVSLQCPALGNPVP-TISWLQNGLPF----SPSPRLQVLEDGQVLQVSTAEVADAASYMC 1725
Query: 302 VPSNGLLHPPSASAYLT--VLYPAQVTAMPPETPLPIGMPGV-IRCPVRANPPLLFVSWT 358
V N SA T V P ++ + E I V + C V A+P V+W
Sbjct: 1726 VAEN---QAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPN-PEVTWY 1781
Query: 359 KDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPP 418
KD +AL L + GT +L + G Y+C N+ G + ++ + PP
Sbjct: 1782 KDSQALSLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALNAAGR--DQKLVQLSVLVPP 1838
Query: 419 AFIERPK---EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLI 472
AF + P+ + VG + ++ C P P V+W K G+ L Q + L
Sbjct: 1839 AFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLE 1898
Query: 473 LRPLTKEAHGHWECSASNAVARVATSTNVYV 503
++ G + C SN + + V
Sbjct: 1899 IQEAQVSDKGLYSCKVSNVAGEAVRTFTLTV 1929
Score = 113 bits (282), Expect = 1e-24
Identities = 119/486 (24%), Positives = 187/486 (38%), Gaps = 46/486 (9%)
Query: 24 PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83
P VV V A E V+L C+ A P I W + G + +
Sbjct: 2763 PSVVRAV--AEEEVLLPCE----ASGIPRPTITWQKEGLNVATGVS-------------- 2802
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETP 142
++ G L+I ED G Y C I ++ + L V PP +
Sbjct: 2803 -TQVLPGGQLRIAHASPEDAGNYLC--------IAKNSAGSAMGKTRLVVQVPPVIENGL 2853
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSS 201
P L E L C ARGSP P++TW G+ + +G+ +Q +G L ++ +E +
Sbjct: 2854 PD-LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDA 2912
Query: 202 GVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSW 261
G YTC A + G A L +L PV P + ++ + L C A P
Sbjct: 2913 GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 2972
Query: 262 FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLY 321
D +S +L+ A +D+G Y C N + + S
Sbjct: 2973 VNDRPVTEGVSEQDG------GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEA 3026
Query: 322 PAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 381
P P+G + C VR +P + + W KDG L+ Q GSL
Sbjct: 3027 PVLQGEAFSYLVEPVGGSIQLDCVVRGDP-VPDIHWIKDGLPLRGSHLRHQLQN--GSLT 3083
Query: 382 IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCS 441
I D G Y C N +G A V ++L++ P F P++ + G ++ + C
Sbjct: 3084 IHRTERDDAGRYQCLAENEMGVA--KKVVILVLQSAPVFQVEPQDMTVRS-GDDVALRCQ 3140
Query: 442 AQGDPPPVVSWTKVGRGLQGQAQVDS--NSSLILRPLTKEAHGHWECSASNAVARVATST 499
A G+P P + W + G+ L+ ++ + + SL L + G ++C A N +
Sbjct: 3141 ATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARA 3200
Query: 500 NVYVLG 505
+ V G
Sbjct: 3201 FLVVRG 3206
Score = 109 bits (273), Expect = 1e-23
Identities = 142/499 (28%), Positives = 196/499 (39%), Gaps = 62/499 (12%)
Query: 26 VVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRV 85
V V A +V L C PA P+ I WL+ G LP SPR+
Sbjct: 1661 VEEVTVNASSTVSLQC----PALGNPVPTISWLQNG--LPFSP-----SPRLQV------ 1703
Query: 86 RLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-LTVNSPPQFQ----E 140
L+ G LQ+ V D Y C + E+ + + L V PP+ E
Sbjct: 1704 -LEDGQVLQVSTAEVADAASYMC--------VAENQAGSAEKLFTLRVQVPPRIAGLDLE 1754
Query: 141 TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT--LRIRRVER 198
A+L V+L C P P VTW + L G+ +V + GT L++ R
Sbjct: 1755 QVTAILN----SSVSLPCDVHAHPNPEVTWYKDSQALSLGE-EVFLLPGTHTLQLGRARL 1809
Query: 199 GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNS----TVNASQDVSLACHAEAYP 254
SG+YTC+A + G QL VL PP P+ V L+C +A P
Sbjct: 1810 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 1869
Query: 255 ANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSA 313
T +W++D + L R + L G L + Q D G Y+C SN +
Sbjct: 1870 -EPTVTWYKDGQPLV----LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSN-VAGEAVR 1923
Query: 314 SAYLTVLYPAQVTAMPPETPLPI-GMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG- 371
+ LTV P ET + G P V+ C V + P V+W KD ++ G
Sbjct: 1924 TFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAPTVTWLKDRMPVESSAVHGV 1982
Query: 372 WSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQE 431
S+G G L ++ G Y+C N+ A V VL+ AP E+
Sbjct: 1983 VSRG--GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLV-APRIRSSGVAREHHVL 2039
Query: 432 VGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD------SNSSLILRPLTKEAHGHWE 485
G+E+ + C A G PPP V+W K G L GQ SL+L+ L G +
Sbjct: 2040 EGQEVRLDCEADGQPPPDVAWLKDGSPL-GQDMGPHLRFYLDGGSLVLKGLRASDAGAYT 2098
Query: 486 CSASNAVARVATSTNVYVL 504
C A N A V VL
Sbjct: 2099 CVAHNPAGEDARLHTVNVL 2117
Score = 106 bits (264), Expect = 1e-22
Identities = 148/558 (26%), Positives = 225/558 (40%), Gaps = 61/558 (10%)
Query: 88 QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQ-FQETPPAVL 146
+ G L+I G V D+G Y+C V F DF L V++PP + +
Sbjct: 269 EDGQVLRITGSHVGDEGRYQC-VAFSPAGQQARDF------QLRVHAPPTIWGSNETGEV 321
Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSSGVYT 205
V E V L C ARG P P++TW G L V + G L++ R + +GVYT
Sbjct: 322 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 381
Query: 206 CQASSTEGSATHATQLLVLGPPVIVVP---PKNSTVNASQDVSLACHAEAYPANLTYSWF 262
C+AS+ G+A AT+L V PP I P A + V+L C A +P+ T SW
Sbjct: 382 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP-TLSWH 440
Query: 263 QDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLY 321
+ + V + R+ DGS LRL + +G Y+CV S+ P+ A L
Sbjct: 441 HEGLPVAESN----ESRLETDGSVLRLESPGEASSGLYSCVASS-----PAGEAVLQYSV 491
Query: 322 PAQVTAMPPETPLPIGMPGV-------IRCPVRAN-PPLLFVSWTKDGK-ALQLDKFPGW 372
QV PP+ + G+ V + P +A+ P+ + W ++G+ A +L
Sbjct: 492 EVQV---PPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVA 548
Query: 373 SQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV 432
SQGT +L I D G ++C N GTAG V + P +E P +Y
Sbjct: 549 SQGT--TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGX 606
Query: 433 GRELLIPCS----------AQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA-- 480
P + A PP V W G L G+ + + PL E
Sbjct: 607 EHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSLPPPLQIEKVD 665
Query: 481 ---HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQ 537
G + C+A+N + VL P++ A+ + A+V+ E G
Sbjct: 666 LRDEGIYTCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECLASGVPPP 724
Query: 538 RFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS- 596
S W+ + + W+ + V V L + Q + +A N GS
Sbjct: 725 DVS-WF-----KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 778
Query: 597 EIVLSAPEGLPTTPAAPG 614
+ ++ P + P+ PG
Sbjct: 779 GLRVNVPPRITLPPSLPG 796
Score = 106 bits (264), Expect = 1e-22
Identities = 123/435 (28%), Positives = 184/435 (42%), Gaps = 45/435 (10%)
Query: 91 ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQE 150
A LQ++ V D G Y C L+Q + N L V P F L V+E
Sbjct: 933 ALLQVDRADVWDAGHYTCEA--LNQAGRSEKHYN-----LNVWVAPVFPLRESHTLTVRE 985
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDL-GQGQG--QVQVQNGTLRIRRVERGSSGVYTCQ 207
P +L C RG P P ++W+ G+ L G+G G V L + + + G YTC+
Sbjct: 986 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 1045
Query: 208 ASSTEGSATHATQLLVLGPPVIVVPPKNST-VNASQD--VSLACHAEAYPANLTYSWFQD 264
S+ G+++ QL V PP I P + T V+ QD +L C+A P T +W +D
Sbjct: 1046 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP-TVTWERD 1104
Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQ 324
V LQ + + SL + Q G Y+CV N L L+VL P +
Sbjct: 1105 GQPVGAELGLQLQNQ---GQSLHVERAQAAHTGRYSCVAEN-LAGRAERKFELSVLVPPE 1160
Query: 325 VTA-MPPETPLPIGM--PGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 381
+ + P T + + P + C PP + W + + + PG E + +
Sbjct: 1161 LIGDLDPLTNITAALHSPLTLLCEAMGIPPPA-IRWFRGEEPVS----PG-----EDTYL 1210
Query: 382 IALG--------NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV- 432
+A G E G YSC N G A + VL+ PP+ EE + +
Sbjct: 1211 LAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLD 1268
Query: 433 GRELLIPCSAQGDPPPVVSWTKVGRGL-QGQAQVDSNSSLILRPL--TKEAHGHWECSAS 489
G+ + C+ G P P ++W K GR L +G A S ++L+ L + GH+ C A+
Sbjct: 1269 GQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAA 1328
Query: 490 NAVARVATSTNVYVL 504
NAV + VL
Sbjct: 1329 NAVGEKTKHFQLSVL 1343
Score = 106 bits (264), Expect = 1e-22
Identities = 112/431 (25%), Positives = 174/431 (40%), Gaps = 33/431 (7%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ--ETPPAVLE 147
G L + ++ +G Y C + + +D + L V+ PPQ PP +
Sbjct: 1026 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQD-------LQLEVHVPPQIAGPREPPTQVS 1078
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTC 206
V + TL C A G P P VTW+ G+ +G G Q+Q Q +L + R + +G Y+C
Sbjct: 1079 VVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 1138
Query: 207 QASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
A + G A +L VL PP ++ P N T ++L C A P WF+
Sbjct: 1139 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP-AIRWFR 1197
Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPA 323
V S + + L++ TQ D+G Y+C+ SN + + VL P
Sbjct: 1198 GEEPV---SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNE-AGEARRNFSVEVLVPP 1253
Query: 324 QVTAMPPETPLPI--GMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSL 380
+ E + + G + C V +P P L +W KDG+ L + +G L
Sbjct: 1254 SIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFKDGRPLA--RGDAHHISPDGVL 1309
Query: 381 IIAL-GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF---IERPKEEYFQEVGREL 436
+ L N + G YSC N++G VLL AP + EE V +
Sbjct: 1310 LQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLL-APTILGGAEDSADEEVTVTVNNPI 1368
Query: 437 LIPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNAVA 493
+ C A P P ++W K G + + L + KE G + C +N +
Sbjct: 1369 SLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1428
Query: 494 RVATSTNVYVL 504
+ +V VL
Sbjct: 1429 EAVKNYHVEVL 1439
Score = 103 bits (258), Expect = 7e-22
Identities = 134/525 (25%), Positives = 207/525 (39%), Gaps = 77/525 (14%)
Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPP--AGRPPLHVIEWLRFGFLLPIFIQF 70
V+ + + P+++ G + ++G L P A P+ I+WL+ G
Sbjct: 486 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--------- 536
Query: 71 GLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHL 130
R + G +G +L I+ + ++ G + C+ + G+ V +
Sbjct: 537 -----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA-------TNEAGTAGAEVEV 584
Query: 131 TVNSPPQFQETPPAVLEV---------QELEPVTLRC---VARG---SPLPHVT--WKLR 173
+V+ E P VLEV + C V RG P P + W
Sbjct: 585 SVHG-----EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSP 639
Query: 174 GKDLGQGQGQVQVQN--GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVV 231
G G+ G + L+I +V+ G+YTC A++ G + L VL PP I
Sbjct: 640 GSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP 699
Query: 232 PPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLA 290
P N V + V+L C A P SWF+ + V V + VDG LR+
Sbjct: 700 GPVNKAVLENASVTLECLASGVPPP-DVSWFKGHQPV----SSWMGVTVSVDGRVLRIEQ 754
Query: 291 TQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPG--VIRCPVR- 347
Q DAG Y CV SN + + Y +V +PP LP +PG ++ PVR
Sbjct: 755 AQLSDAGSYRCVASN-------VAGSTELRYGLRVN-VPPRITLPPSLPGPVLVNTPVRL 806
Query: 348 ----ANPPLLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLG 402
P + W KDG + PG G L +A G YSC +++G
Sbjct: 807 TCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG 866
Query: 403 TAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE-LLIPCSAQGDPPPVVSWTKVGRGLQG 461
V +V + PP+ + +E V E + + C + PPPV+SW K GR L+
Sbjct: 867 EDRQDVVLQVHM--PPSIL--GEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEP 922
Query: 462 QAQVDSNSSLILRPLTKE---AHGHWECSASNAVARVATSTNVYV 503
+ V ++ L + + GH+ C A N R N+ V
Sbjct: 923 RPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNV 967
Score = 102 bits (253), Expect = 3e-21
Identities = 139/521 (26%), Positives = 193/521 (37%), Gaps = 80/521 (15%)
Query: 28 SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFG---------------- 71
+V G AG+S+ L CD A P+ I WL+ L+ + + +
Sbjct: 105 NVSGMAGQSLTLECD----ANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 160
Query: 72 ------LYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANG 125
L+ PRI P GR Q G S Q + W F P
Sbjct: 161 LDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKA------PWXAGLAGFEQFPTPH------ 208
Query: 126 SWVHLTVNSPPQFQETPPAVL---EVQEL-----EPVTLRCVARGSPLPHVTWKLRGKDL 177
SPP PP+VL QE+ V L+C G P P V W + +
Sbjct: 209 ------AFSPP----APPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPV 258
Query: 178 GQGQGQVQVQNG--TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKN 235
G +QVQ LRI G G Y C A S G QL V PP I +
Sbjct: 259 LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNET 318
Query: 236 STVNASQD--VSLACHAEAYPA-NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQ 292
V +D V L C A P N+T WF+D + +++ V L+L Q
Sbjct: 319 GEVAVMEDHLVQLLCEARGVPTPNIT--WFKDGALLPTSTKV---VYTRGGRQLQLGRAQ 373
Query: 293 PDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVT---AMPPETPLPIGMPGVIRCPVRAN 349
DAG YTC SN + A+ L V P + P G P + C R +
Sbjct: 374 SSDAGVYTCKASNAVGAAEKATR-LDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGH 432
Query: 350 P-PLLFVSWTKDGKALQLDKFPGWSQGTEGSLI-IALGNEDALGEYSCTPYNSLGTAGPS 407
P P L SW +G L + + T+GS++ + E + G YSC + G A
Sbjct: 433 PSPTL--SWHHEG--LPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ 488
Query: 408 PVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR---GLQGQAQ 464
V + P + + VG+ L +PC A G P P + W + GR L G
Sbjct: 489 YSVEVQV-PPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQV 547
Query: 465 VDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLG 505
++L + + + G + C A+N V V G
Sbjct: 548 ASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 588
Score = 97.4 bits (241), Expect = 7e-20
Identities = 115/434 (26%), Positives = 167/434 (38%), Gaps = 43/434 (9%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH--LTVNSPPQFQETPPAVLE 147
G L+IE ++ D G Y C + A + + L VN PP+ P
Sbjct: 747 GRVLRIEQAQLSDAGSYRCVA---------SNVAGSTELRYGLRVNVPPRITLPPSLPGP 797
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQVQNG--TLRIRRVERGSSGVY 204
V PV L C A G+P P + W G + G +QV G L + SG Y
Sbjct: 798 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 857
Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
+C A S G L V PP I+ N +V A++ V+L C + A P + SW++D
Sbjct: 858 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKD 916
Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPD---DAGCYTCVPSNGLLHPPSASAYLTVLY 321
L+PR + + LL DAG YTC N S Y ++
Sbjct: 917 G------RPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA--GRSEKHYNLNVW 968
Query: 322 PAQVTAMPPETPLPI--GMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG- 378
A V + L + G P + C R P +SW KDG+ L PG G +
Sbjct: 969 VAPVFPLRESHTLTVREGHPTSLSCECR-GVPFPKISWRKDGQPL-----PGEGAGLQHV 1022
Query: 379 ---SLIIALGNEDAL--GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG 433
++ LG G Y+C N +G + V + A P +
Sbjct: 1023 SAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQD 1082
Query: 434 RELLIPCSAQGDPPPVVSWTKVGR--GLQGQAQVDSNSSLILRPLTKEAH-GHWECSASN 490
+ C+A G PPP V+W + G+ G + Q+ + + + AH G + C A N
Sbjct: 1083 GVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN 1142
Query: 491 AVARVATSTNVYVL 504
R + VL
Sbjct: 1143 LAGRAERKFELSVL 1156
Score = 96.3 bits (238), Expect = 2e-19
Identities = 128/513 (24%), Positives = 196/513 (38%), Gaps = 67/513 (13%)
Query: 16 QGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSP 75
Q A R P VSVV L C+ G+PP + W R G P+ + GL
Sbjct: 1066 QIAGPREPPTQVSVVQDG--VATLECNA---TGKPP-PTVTWERDG--QPVGAELGL--- 1114
Query: 76 RIDPDYVGRVRLQ-KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNS 134
+LQ +G SL +E + G Y C L L+V
Sbjct: 1115 ----------QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK-------FELSVLV 1157
Query: 135 PPQF--QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TL 191
PP+ P + P+TL C A G P P + W + + G+ + G L
Sbjct: 1158 PPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWML 1217
Query: 192 RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA--SQDVSLACH 249
++ + + SG+Y+C AS+ G A + VL PP I + Q L C+
Sbjct: 1218 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 1277
Query: 250 AEAYPANLTYSWFQDNI-----NVFHISRLQPRVRILVDGSL-RLLATQPDDAGCYTCVP 303
+P +WF+D + HIS DG L ++L AG Y+C+
Sbjct: 1278 VTGHPQP-KLTWFKDGRPLARGDAHHISP---------DGVLLQVLQANLSSAGHYSCIA 1327
Query: 304 SNGLLHPPSASAYLTVLYPAQV----TAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTK 359
+N + +L P + + E + + P + C A P ++W K
Sbjct: 1328 ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPN-ITWMK 1386
Query: 360 DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 419
DG + + GT G I+ EDA G+Y+C N LG A + VL+ PP+
Sbjct: 1387 DGAPFEASRNIQLLPGTHGLQILNAQKEDA-GQYTCVVTNELGEAVKNYHVEVLI--PPS 1443
Query: 420 FI------ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSL 471
E +E +V L + C + PPP + W K G+ + + QV L
Sbjct: 1444 ISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL 1503
Query: 472 I-LRPLTKEAHGHWECSASNAVARVATSTNVYV 503
+ ++P G + C A+N NV +
Sbjct: 1504 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 1536
Score = 79.7 bits (195), Expect = 1e-14
Identities = 187/779 (24%), Positives = 269/779 (34%), Gaps = 156/779 (20%)
Query: 145 VLEVQELEPVTLR-------CVARGSPLPHVTWKL--RGKDLGQGQGQVQVQNGTLRIRR 195
VLE++ L V L C G+P P VTW+ + L G ++ G+L +
Sbjct: 4 VLEIKGLGDVALTVGLEAGGCGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLAS 63
Query: 196 VERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN--ASQDVSLACHAEAY 253
V SG Y CQA++ GS + +L+V PP I + + V+ A Q ++L C A +
Sbjct: 64 VSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGF 123
Query: 254 P---------ANLT--------YSW-----------FQDNINVFHISRLQP----RVRIL 281
P A L Y W D H R+QP R
Sbjct: 124 PVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQ 183
Query: 282 VDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGV 341
GS + A + P+ PP+ + L +V + G
Sbjct: 184 AGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGL-------AGADVE 236
Query: 342 IRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNE-DALGEYSCTPYNS 400
++C + P V WTKD + + L P +G ++ G+ G Y C ++
Sbjct: 237 LQC-WTSGVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP 294
Query: 401 LGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP--CSAQGDPPPVVSWTKVGRG 458
G RV APP I E V + L+ C A+G P P ++W K G
Sbjct: 295 AGQQARDFQLRV--HAPPT-IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL 351
Query: 459 LQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAV--ARVATSTNVYVLGTSPHVVTN 513
L +V L L G + C ASNAV A AT +VYV T
Sbjct: 352 LPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGR 411
Query: 514 VSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPG 573
VV G V+ E G S W HH+ +PV ++
Sbjct: 412 PYVVKAVAGRPVALECVARGHPSPTLS-W-----------HHE----GLPVAESN----- 450
Query: 574 LQPHTQYQFSVL---AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGL 630
+ + SVL + + SG +S V S+P G + ++PP L GL
Sbjct: 451 -ESRLETDGSVLRLESPGEASSGLYS-CVASSPAGEAVLQYS---VEVQVPPQLLVAEGL 505
Query: 631 VAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQ----GSQGWEVLDPAVAGTETELLVPGL 686
V T G P EL P + G + Q G E+ VA T L + +
Sbjct: 506 GQVTTIVG-----QPLEL-PCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHV 559
Query: 687 IKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFL 746
D +G F +N A + + +EV PG+L P+ G
Sbjct: 560 ELD---------HSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPI------GQYHW 604
Query: 747 GVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKL 806
G S A C DPP+ P G SP S
Sbjct: 605 GXEHHSSFPAAC-----------------DPPVHRGWGAHPKPPLVEGWCSPGS------ 641
Query: 807 QGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQER 865
LWG+P G P + PP PL +E + +G + T A + +
Sbjct: 642 ------------LWGEPTGIPVAYSLPP----PLQIEKVDLRDEGIYTCAATNLAGESK 684
Score = 66.2 bits (160), Expect = 2e-10
Identities = 110/463 (23%), Positives = 173/463 (37%), Gaps = 69/463 (14%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETP-PAV 145
L++G SL + + D G YEC+ + + L V PP +E A
Sbjct: 54 LEEG-SLFLASVSPADSGDYECQA-------TNEVGSTSRRAKLVVYVPPSIREDGRKAN 105
Query: 146 LEVQELEPVTLRCVARGSPLPHVTWKL-------------RGKDLGQGQ--GQVQVQNG- 189
+ + +TL C A G P+P + W G DLG GQ G + G
Sbjct: 106 VSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQ 165
Query: 190 TLRIRRVERGSSGVYTCQA-SSTEGSATHATQLL---------VLGPPVIVVPPKNSTVN 239
+L R++ G SG QA S + A L PP PP
Sbjct: 166 SLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPP---APPSVLGAG 222
Query: 240 ASQ--------DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLA 290
A+Q DV L C P W +D V P +++ DG LR+
Sbjct: 223 AAQEVLGLAGADVELQCWTSGVPTP-QVEWTKDRQPVLPGG---PHLQVQEDGQVLRITG 278
Query: 291 TQPDDAGCYTCVPSNGLLHPPSASA---YLTVLYPAQVTAMPPETPLPIGMPGVIR--CP 345
+ D G Y CV P A L V P + + + +++ C
Sbjct: 279 SHVGDEGRYQCV----AFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCE 334
Query: 346 VRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAG 405
R P ++W KDG L +++G + + DA G Y+C N++G A
Sbjct: 335 AR-GVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDA-GVYTCKASNAVGAA- 391
Query: 406 PSPVTRVLLKAPPAFIERPKEEYFQE--VGRELLIPCSAQGDPPPVVSWTKVGRGL--QG 461
TR+ + PP Y + GR + + C A+G P P +SW G +
Sbjct: 392 -EKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESN 450
Query: 462 QAQVDSNSSLI-LRPLTKEAHGHWECSASNAVARVATSTNVYV 503
+++++++ S++ L + + G + C AS+ +V V
Sbjct: 451 ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV 493
Score = 63.9 bits (154), Expect = 8e-10
Identities = 48/145 (33%), Positives = 68/145 (46%), Gaps = 11/145 (7%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTV-NSPPQFQETP 142
R +LQ G SL I +D G Y+C + E++ V + V S P FQ
Sbjct: 3074 RHQLQNG-SLTIHRTERDDAGRYQC--------LAENEMGVAKKVVILVLQSAPVFQ-VE 3123
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202
P + V+ + V LRC A G P P + W G+ L + + +G+L + VE G +G
Sbjct: 3124 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 3183
Query: 203 VYTCQASSTEGSATHATQLLVLGPP 227
Y C A + GSAT L+V G P
Sbjct: 3184 TYDCVAHNLLGSATARAFLVVRGEP 3208
Score = 58.5 bits (140), Expect = 4e-08
Identities = 98/443 (22%), Positives = 159/443 (35%), Gaps = 64/443 (14%)
Query: 93 LQIEGLRVEDQGWYECRVFF-LDQHIPEDDFANGSWVHLTVNSPPQFQETPP----AVLE 147
LQI + ED G Y C V L + + H+ V PP + P V E
Sbjct: 1406 LQILNAQKEDAGQYTCVVTNELGEAVKN--------YHVEVLIPPSISKDDPLGEVGVKE 1457
Query: 148 VQEL--EPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVY 204
V+ +TL C + P P + W G+ + QV + L+I+ + SG Y
Sbjct: 1458 VKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRY 1517
Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNST--------------------VNASQDV 244
C A++ G +L+ PP+ S + +
Sbjct: 1518 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 1577
Query: 245 SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVP 303
L C A P +W++++ + V +L G L++ + ++AG Y+C
Sbjct: 1578 YLYCDTNAIPPP-DLTWYREDQPL----SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKA 1632
Query: 304 SNGL----LHPPSASAYLTVLYPAQVTA----MPPETPLPIGMPGVIRCPVRANPPLLFV 355
SN + LH L VL P + + E + ++CP N P+ +
Sbjct: 1633 SNEVGEDWLH-----YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN-PVPTI 1686
Query: 356 SWTKDGKALQLDKFPGWSQGTEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLL 414
SW ++G L P +G ++ ++ Y C N G+A RV
Sbjct: 1687 SWLQNG--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV-- 1742
Query: 415 KAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSL 471
+ PP E+ + + +PC P P V+W K + L +V +L
Sbjct: 1743 QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTL 1802
Query: 472 ILRPLTKEAHGHWECSASNAVAR 494
L G + C A NA R
Sbjct: 1803 QLGRARLSDSGMYTCEALNAAGR 1825
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 125 bits (315), Expect = 2e-28
Identities = 112/386 (29%), Positives = 166/386 (43%), Gaps = 21/386 (5%)
Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
V LTV + P + P V V E E V L C A G P P +TW+ G ++ G +
Sbjct: 3940 VFLTVQASPVVKPLPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP 3998
Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
G LRI +G Y C A ++ GSA T+L+V PPVI + + L
Sbjct: 3999 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLP 4058
Query: 248 CHAEAYP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306
C A P N+T W +D V S + + I G L + + DAG YTC N
Sbjct: 4059 CKARGSPEPNIT--WDKDGQPV---SGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENA 4113
Query: 307 LLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQL 366
+ +LT+L T +P + L +G +RC R +P + WT + + +
Sbjct: 4114 -VGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPR-IGWTVNDRPVT- 4170
Query: 367 DKFPGWSQGTEGSLI--IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERP 424
G S+ GS + A+ ED+ G Y C N +G V+ V +K P
Sbjct: 4171 ---EGVSEQDGGSTLQRAAVSREDS-GTYVCWAENRVGRT--QAVSFVHVKEAPVLQGEA 4224
Query: 425 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ--AQVDSNSSLILRPLTKEAHG 482
+ VG + + C +GDP P + W K G L+G N SL + ++ G
Sbjct: 4225 FSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAG 4284
Query: 483 HWECSASNAVARVATSTNVYVLGTSP 508
++C A N + VA + VL ++P
Sbjct: 4285 RYQCLAENEMG-VAKKVVILVLQSAP 4309
Score = 125 bits (314), Expect = 2e-28
Identities = 135/495 (27%), Positives = 194/495 (39%), Gaps = 53/495 (10%)
Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLP--IFIQFGLYSPRIDPDYVGRVR 86
VVG A +VL C + P I W R G +L QF
Sbjct: 3591 VVGLAPGQLVLECSV----EAEPAPKITWHRDGIVLQEDAHTQFP--------------- 3631
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWV--HLTVNSPPQFQETPPA 144
++G LQ++ L D G Y C + A + V + +++ P + PPA
Sbjct: 3632 -ERGRFLQLQALSTADSGDYSCTA---------RNAAGSTSVAFRVEIHTVPTIRSGPPA 3681
Query: 145 VLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSGV 203
V V + L C A G P P V+W+ L + ++ G+LRI+ V +G
Sbjct: 3682 V-NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 3740
Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
Y C AS++ GS L VL PP I P N T+ A L C A P L W
Sbjct: 3741 YLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKD 3800
Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN--GLLHPPSASAYLTVLY 321
F + Q R+L +L L A P D+ + CV SN G H +TV
Sbjct: 3801 GQKLDFRLQ--QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAH---RLYQVTVHV 3855
Query: 322 PAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 381
P + + + + P V+ C P VSW+K G L + G+ G+L
Sbjct: 3856 PPTIADDQTDFTVTMMAPVVLTCH-STGIPAPTVSWSKAGAQLGA-RGSGYRVSPSGALE 3913
Query: 382 IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG-RELLIPC 440
I G Y+C+ NS G A V L + + +P + V E+L+PC
Sbjct: 3914 IGQALPIHAGRYTCSARNSAGVAH----KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPC 3969
Query: 441 SAQGDPPPVVSWTKVGRGLQG--QAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATS 498
A G P P ++W K G + QV L + + E G++ C A N+
Sbjct: 3970 EASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK 4029
Query: 499 TNVYVLGTSPHVVTN 513
T + V P V+ N
Sbjct: 4030 TRLVV--QVPPVIEN 4042
Score = 122 bits (305), Expect = 3e-27
Identities = 144/531 (27%), Positives = 204/531 (38%), Gaps = 96/531 (18%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
G S +L C GRPP + W R G P+ ++ G R R L
Sbjct: 800 GRSALLACRA---TGRPP-PTVTWRR-GDGQPLGLRLGAGRG-------SRSRQPDSGVL 847
Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
E + EDQ Y C + + + + + +T ++PPQ + P V V E +P
Sbjct: 848 FFESVAPEDQAPYVCEARNVFGKVQAE-----ARLIVTGHAPPQIASSAPTV-RVLEGQP 901
Query: 154 VTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTE 212
V+L C+ G PLP W G+ L G +G+L + R + +G Y+C A++T
Sbjct: 902 VSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTA 961
Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV---- 268
GS +L+V PP I + N SL C A PA T +W ++ +
Sbjct: 962 GSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP-TITWTKETNALTSRG 1020
Query: 269 --FHISR------LQPRVR--------------------------------------ILV 282
+++S+ QP + +L
Sbjct: 1021 PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLP 1080
Query: 283 DGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA----YLTVLYPAQVTAMPPETPLPIGM 338
GSLRL Q D+G Y C SN P+ SA L V P QV P + +G
Sbjct: 1081 SGSLRLAQVQVGDSGHYECTASN-----PAGSASHRYVLGVQVPPQVQPGPRVLKVLVGE 1135
Query: 339 PGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTP 397
+ C NP P L SW+KDG LQ +G +GS+ A G Y C
Sbjct: 1136 ALDLNCVAEGNPEPQL--SWSKDGVVLQ-------GRGPQGSVHFAAIRTSDAGRYRCEA 1186
Query: 398 YNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV-GRELLIPCSAQGDPPPVVSWTK-- 454
NS G RVL PP + + V G +PC A+G P P V+W K
Sbjct: 1187 SNSAGVDAWEVELRVL--EPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGP 1244
Query: 455 VGRGLQGQ--AQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYV 503
L GQ V SL L ++ G +EC A+N V + + V
Sbjct: 1245 SSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVV 1295
Score = 117 bits (292), Expect = 8e-26
Identities = 148/507 (29%), Positives = 214/507 (42%), Gaps = 67/507 (13%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ-KGAS 92
G+ V L C+ G+PP V WL+ G SP + D +R G S
Sbjct: 3232 GQEVRLDCEA---DGQPPPDVA-WLKDG------------SP-LGQDMGPHLRFYLDGGS 3274
Query: 93 LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPA--VLEVQE 150
L ++GLR D G Y C H P + A V++ V PP ++ L +
Sbjct: 3275 LVLKGLRASDAGAYTCVA-----HNPAGEDARLHTVNVLV--PPTIKQGADGSGTLVSRP 3327
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERGSSGVYTCQAS 209
E VT+ C RGSP HV+W G L Q + +G TLRI +V+ +G++TC A+
Sbjct: 3328 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 3387
Query: 210 STEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
S G A L V PPV+ V + V V L C A P L SW +D
Sbjct: 3388 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLV-SWMKDGEP 3446
Query: 268 VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQV-- 325
+ S Q SL+L A D+G Y+CV + LTV+ P +
Sbjct: 3447 LLSQSLEQ-------GPSLQLEAVGAGDSGTYSCVAVSE-AGEARRHFQLTVMEPPHIED 3498
Query: 326 TAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALG 385
+ P E L G P + C + P ++W KDG+A L + S+ T L
Sbjct: 3499 SGQPTELSLTPGAPMELLCDAQGTPQ-PNITWHKDGQA--LTRLENNSRATR-----VLR 3550
Query: 386 NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG---RELLIPCSA 442
DA G Y+C + G S RV ++APP + P+ F VG +L++ CS
Sbjct: 3551 VRDA-GLYTCLAESPAGAIEKS--FRVRVQAPPNIV-GPRGPRF-VVGLAPGQLVLECSV 3605
Query: 443 QGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVARVATST 499
+ +P P ++W + G LQ A + L L+ L+ G + C+A NA + +
Sbjct: 3606 EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAF 3665
Query: 500 NVYVLGTSPHVVTNVSVVALPKGANVS 526
V + H V + + P NVS
Sbjct: 3666 RVEI-----HTVPTIR--SGPPAVNVS 3685
Score = 115 bits (288), Expect = 2e-25
Identities = 140/494 (28%), Positives = 196/494 (39%), Gaps = 39/494 (7%)
Query: 28 SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRL 87
+V G AG+S+ L CD A P+ I WL+ L+ + + + Y + VG RL
Sbjct: 1309 NVSGMAGQSLTLECD----ANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 1364
Query: 88 -QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVL 146
+G SL ++ D G Y CR + DF HL V +PP A
Sbjct: 1365 LDEGQSLHFPRIQEGDSGLYSCRAEN-QAGTAQRDF------HLLVLTPPSVLGAG-AAQ 1416
Query: 147 EVQELE--PVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSG 202
EV L V L+C G P P V W + + G +QVQ LRI G G
Sbjct: 1417 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 1476
Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQD--VSLACHAEAYPA-NLTY 259
Y C A S G QL V PP I + V +D V L C A P N+T
Sbjct: 1477 RYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT- 1535
Query: 260 SWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTV 319
WF+D + +++ V L+L Q DAG YTC SN + A+ L V
Sbjct: 1536 -WFKDGALLPTSTKV---VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATR-LDV 1590
Query: 320 LYPAQVT---AMPPETPLPIGMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQG 375
P + P G P + C R +P P L SW +G L + +
Sbjct: 1591 YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEG--LPVAESNESRLE 1646
Query: 376 TEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGR 434
T+GS++ + E + G YSC + G A V + P + + VG+
Sbjct: 1647 TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV-PPQLLVAEGLGQVTTIVGQ 1705
Query: 435 ELLIPCSAQGDPPPVVSWTKVGR---GLQGQAQVDSNSSLILRPLTKEAHGHWECSASNA 491
L +PC A G P P + W + GR L G ++L + + + G + C A+N
Sbjct: 1706 PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNE 1765
Query: 492 VARVATSTNVYVLG 505
V V G
Sbjct: 1766 AGTAGAEVEVSVHG 1779
Score = 115 bits (287), Expect = 3e-25
Identities = 141/535 (26%), Positives = 203/535 (37%), Gaps = 70/535 (13%)
Query: 14 ISQGADGRGKPEVV------------SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFG 61
+S+ GR K ++V +V GE+ VL C +L G P + + W+R
Sbjct: 499 VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL---GEAPYN-LTWVR-- 552
Query: 62 FLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDD 121
R+ P GRV SL+I G+ D G Y+C
Sbjct: 553 ------------DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVA----------S 590
Query: 122 FANG---SWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLG 178
ANG + V L V PQ + Q +E V + C A G P PH++W + L
Sbjct: 591 NANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE-VKVSCSASGYPTPHISWSRESQAL- 648
Query: 179 QGQGQVQVQ-NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNST 237
Q ++ V GTL I+ V +G Y+CQA++ G+ L PP +
Sbjct: 649 QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 708
Query: 238 VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAG 297
V ++ L C A P W++ + + L P G LR+ A Q DAG
Sbjct: 709 VAVGEEAVLVCEASGVPPPRVI-WYRGGLEMI----LAPEGS--SSGKLRIPAAQERDAG 761
Query: 298 CYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSW 357
YTC N L SA L V + Q+T +P + + +G ++ C PP V+W
Sbjct: 762 TYTCRAVNE-LGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPT-VTW 819
Query: 358 TK-DGKALQLDKFPGWS----QGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRV 412
+ DG+ L L G Q G L + Y C N G V
Sbjct: 820 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 879
Query: 413 LLKAPPAFIERPKEEYFQEVGRELLIPCSA-QGDPPPVVSWTKVGRGLQ--GQAQVDSNS 469
APP E G+ + +PC G P P W K GR L + + ++
Sbjct: 880 TGHAPPQIASSAPTVRVLE-GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG 938
Query: 470 SLILRPLTKEAHGHWECSASNAVARVATSTNVYVL------GTSPHVVTNVSVVA 518
SL L +E G + C A+N + V T+ H +TN V A
Sbjct: 939 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPA 993
Score = 114 bits (285), Expect = 5e-25
Identities = 113/420 (26%), Positives = 170/420 (40%), Gaps = 31/420 (7%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
R+ + +L I+G+ ED G Y C+ + + V L PP
Sbjct: 653 RIHVDAQGTLIIQGVAPEDAGNYSCQA-------TNEVGTDQETVTLYYTDPPSVSAVNA 705
Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG-QGQVQVQNGTLRIRRVERGSSG 202
VL V E L C A G P P V W G ++ +G +G LRI + +G
Sbjct: 706 VVL-VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS---SSGKLRIPAAQERDAG 761
Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWF 262
YTC+A + G A+ QL V P + P++ TV + LAC A P T +W
Sbjct: 762 TYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPP-TVTWR 820
Query: 263 QDNINVFHI---SRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTV 319
+ + + + R R G L + P+D Y C N + A A L V
Sbjct: 821 RGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN-VFGKVQAEARLIV 879
Query: 320 L--YPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG--WSQG 375
P Q+ + P + G P + C V A PL W KDG+ L PG S
Sbjct: 880 TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP----PGSRHSIR 935
Query: 376 TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 435
+GSL + ++ G YSC N+ G+ ++++ PP I + G
Sbjct: 936 ADGSLHLDRALQEHAGRYSCVATNTAGSQHRD--VELVVQVPPR-IHPTATHHITNEGVP 992
Query: 436 LLIPCSAQGDPPPVVSWTKVGRGLQGQA---QVDSNSSLILRPLTKEAHGHWECSASNAV 492
+PC A G P P ++WTK L + V +L++ + + G + C+A+N V
Sbjct: 993 ASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 1052
Score = 113 bits (283), Expect = 9e-25
Identities = 123/451 (27%), Positives = 183/451 (40%), Gaps = 53/451 (11%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ------- 139
L +G LQI+ +V D G Y C + +D ++ + PP FQ
Sbjct: 2689 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD-------FNVLIQVPPMFQKVGDFSA 2741
Query: 140 ---------ETPPAVLEVQEL---EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
E V E +E+ P L C P P +TW + L G +Q
Sbjct: 2742 AFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ 2801
Query: 188 NG-TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPP----KNSTVNASQ 242
G L+I V ++G Y+C+AS+ G +LLVL PPVI+ + TVNAS
Sbjct: 2802 GGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS 2861
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTC 301
VSL C A P T SW Q+ + PR+++L DG L++ + DA Y C
Sbjct: 2862 TVSLQCPALGNPVP-TISWLQNGLPF----SPSPRLQVLEDGQVLQVSTAEVADAASYMC 2916
Query: 302 VPSNGLLHPPSASAYLT--VLYPAQVTAMPPETPLPIGMPGV-IRCPVRANPPLLFVSWT 358
V N SA T V P ++ + E I V + C V A+P V+W
Sbjct: 2917 VAEN---QAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPN-PEVTWY 2972
Query: 359 KDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPP 418
KD +AL L + GT +L + G Y+C N+ G + ++ + PP
Sbjct: 2973 KDSQALSLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALNAAGR--DQKLVQLSVLVPP 3029
Query: 419 AFIERPK---EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLI 472
AF + P+ + VG + ++ C P P V+W K G+ L Q + L
Sbjct: 3030 AFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLE 3089
Query: 473 LRPLTKEAHGHWECSASNAVARVATSTNVYV 503
++ G + C SN + + V
Sbjct: 3090 IQEAQVSDKGLYSCKVSNVAGEAVRTFTLTV 3120
Score = 113 bits (282), Expect = 1e-24
Identities = 119/486 (24%), Positives = 187/486 (38%), Gaps = 46/486 (9%)
Query: 24 PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83
P VV V A E V+L C+ A P I W + G + +
Sbjct: 3954 PSVVRAV--AEEEVLLPCE----ASGIPRPTITWQKEGLNVATGVS-------------- 3993
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETP 142
++ G L+I ED G Y C I ++ + L V PP +
Sbjct: 3994 -TQVLPGGQLRIAHASPEDAGNYLC--------IAKNSAGSAMGKTRLVVQVPPVIENGL 4044
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSS 201
P L E L C ARGSP P++TW G+ + +G+ +Q +G L ++ +E +
Sbjct: 4045 PD-LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDA 4103
Query: 202 GVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSW 261
G YTC A + G A L +L PV P + ++ + L C A P
Sbjct: 4104 GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 4163
Query: 262 FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLY 321
D +S +L+ A +D+G Y C N + + S
Sbjct: 4164 VNDRPVTEGVSEQDG------GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEA 4217
Query: 322 PAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 381
P P+G + C VR +P + + W KDG L+ Q GSL
Sbjct: 4218 PVLQGEAFSYLVEPVGGSIQLDCVVRGDP-VPDIHWIKDGLPLRGSHLRHQLQN--GSLT 4274
Query: 382 IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCS 441
I D G Y C N +G A V ++L++ P F P++ + G ++ + C
Sbjct: 4275 IHRTERDDAGRYQCLAENEMGVA--KKVVILVLQSAPVFQVEPQDMTVRS-GDDVALRCQ 4331
Query: 442 AQGDPPPVVSWTKVGRGLQGQAQVDS--NSSLILRPLTKEAHGHWECSASNAVARVATST 499
A G+P P + W + G+ L+ ++ + + SL L + G ++C A N +
Sbjct: 4332 ATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARA 4391
Query: 500 NVYVLG 505
+ V G
Sbjct: 4392 FLVVRG 4397
Score = 109 bits (273), Expect = 1e-23
Identities = 142/499 (28%), Positives = 196/499 (39%), Gaps = 62/499 (12%)
Query: 26 VVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRV 85
V V A +V L C PA P+ I WL+ G LP SPR+
Sbjct: 2852 VEEVTVNASSTVSLQC----PALGNPVPTISWLQNG--LPFSP-----SPRLQV------ 2894
Query: 86 RLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-LTVNSPPQFQ----E 140
L+ G LQ+ V D Y C + E+ + + L V PP+ E
Sbjct: 2895 -LEDGQVLQVSTAEVADAASYMC--------VAENQAGSAEKLFTLRVQVPPRIAGLDLE 2945
Query: 141 TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT--LRIRRVER 198
A+L V+L C P P VTW + L G+ +V + GT L++ R
Sbjct: 2946 QVTAILN----SSVSLPCDVHAHPNPEVTWYKDSQALSLGE-EVFLLPGTHTLQLGRARL 3000
Query: 199 GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNS----TVNASQDVSLACHAEAYP 254
SG+YTC+A + G QL VL PP P+ V L+C +A P
Sbjct: 3001 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 3060
Query: 255 ANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSA 313
T +W++D + L R + L G L + Q D G Y+C SN +
Sbjct: 3061 -EPTVTWYKDGQPLV----LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSN-VAGEAVR 3114
Query: 314 SAYLTVLYPAQVTAMPPETPLPI-GMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG- 371
+ LTV P ET + G P V+ C V + P V+W KD ++ G
Sbjct: 3115 TFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAPTVTWLKDRMPVESSAVHGV 3173
Query: 372 WSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQE 431
S+G G L ++ G Y+C N+ A V VL+ AP E+
Sbjct: 3174 VSRG--GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLV-APRIRSSGVAREHHVL 3230
Query: 432 VGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD------SNSSLILRPLTKEAHGHWE 485
G+E+ + C A G PPP V+W K G L GQ SL+L+ L G +
Sbjct: 3231 EGQEVRLDCEADGQPPPDVAWLKDGSPL-GQDMGPHLRFYLDGGSLVLKGLRASDAGAYT 3289
Query: 486 CSASNAVARVATSTNVYVL 504
C A N A V VL
Sbjct: 3290 CVAHNPAGEDARLHTVNVL 3308
Score = 107 bits (268), Expect = 5e-23
Identities = 122/435 (28%), Positives = 182/435 (41%), Gaps = 45/435 (10%)
Query: 91 ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQE 150
A LQ++ V D G Y C H E + WV P F L V+E
Sbjct: 2124 ALLQVDRADVWDAGHYTCEALNQAGH-SEKHYNLNVWV------APVFPLRESHTLTVRE 2176
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDL-GQGQG--QVQVQNGTLRIRRVERGSSGVYTCQ 207
P +L C RG P P ++W+ G+ L G+G G V L + + + G YTC+
Sbjct: 2177 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 2236
Query: 208 ASSTEGSATHATQLLVLGPPVIVVPPKNST-VNASQD--VSLACHAEAYPANLTYSWFQD 264
S+ G+++ QL V PP I P + T V+ QD +L C+A P T +W +D
Sbjct: 2237 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP-TVTWERD 2295
Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQ 324
V LQ + + SL + Q G Y+CV N L L+VL P +
Sbjct: 2296 GQPVGAELGLQLQNQ---GQSLHVERAQAAHTGRYSCVAEN-LAGRAERKFELSVLVPPE 2351
Query: 325 VTA-MPPETPLPIGM--PGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 381
+ + P T + + P + C PP + W + + + PG E + +
Sbjct: 2352 LIGDLDPLTNITAALHSPLTLLCEAMGIPPPA-IRWFRGEEPVS----PG-----EDTYL 2401
Query: 382 IALG--------NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV- 432
+A G E G YSC N G A + VL+ PP+ EE + +
Sbjct: 2402 LAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLD 2459
Query: 433 GRELLIPCSAQGDPPPVVSWTKVGRGL-QGQAQVDSNSSLILRPL--TKEAHGHWECSAS 489
G+ + C+ G P P ++W K GR L +G A S ++L+ L + GH+ C A+
Sbjct: 2460 GQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAA 2519
Query: 490 NAVARVATSTNVYVL 504
NAV + VL
Sbjct: 2520 NAVGEKTKHFQLSVL 2534
Score = 106 bits (264), Expect = 1e-22
Identities = 148/558 (26%), Positives = 225/558 (40%), Gaps = 61/558 (10%)
Query: 88 QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQ-FQETPPAVL 146
+ G L+I G V D+G Y+C V F DF L V++PP + +
Sbjct: 1460 EDGQVLRITGSHVGDEGRYQC-VAFSPAGQQARDF------QLRVHAPPTIWGSNETGEV 1512
Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSSGVYT 205
V E V L C ARG P P++TW G L V + G L++ R + +GVYT
Sbjct: 1513 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 1572
Query: 206 CQASSTEGSATHATQLLVLGPPVIVVP---PKNSTVNASQDVSLACHAEAYPANLTYSWF 262
C+AS+ G+A AT+L V PP I P A + V+L C A +P+ T SW
Sbjct: 1573 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP-TLSWH 1631
Query: 263 QDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLY 321
+ + V + R+ DGS LRL + +G Y+CV S+ P+ A L
Sbjct: 1632 HEGLPVAESN----ESRLETDGSVLRLESPGEASSGLYSCVASS-----PAGEAVLQYSV 1682
Query: 322 PAQVTAMPPETPLPIGMPGV-------IRCPVRAN-PPLLFVSWTKDGK-ALQLDKFPGW 372
QV PP+ + G+ V + P +A+ P+ + W ++G+ A +L
Sbjct: 1683 EVQV---PPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVA 1739
Query: 373 SQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV 432
SQGT +L I D G ++C N GTAG V + P +E P +Y
Sbjct: 1740 SQGT--TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGX 1797
Query: 433 GRELLIPCS----------AQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA-- 480
P + A PP V W G L G+ + + PL E
Sbjct: 1798 EHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSLPPPLQIEKVD 1856
Query: 481 ---HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQ 537
G + C+A+N + VL P++ A+ + A+V+ E G
Sbjct: 1857 LRDEGIYTCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECLASGVPPP 1915
Query: 538 RFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS- 596
S W+ + + W+ + V V L + Q + +A N GS
Sbjct: 1916 DVS-WF-----KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 1969
Query: 597 EIVLSAPEGLPTTPAAPG 614
+ ++ P + P+ PG
Sbjct: 1970 GLRVNVPPRITLPPSLPG 1987
Score = 106 bits (264), Expect = 1e-22
Identities = 112/431 (25%), Positives = 174/431 (40%), Gaps = 33/431 (7%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ--ETPPAVLE 147
G L + ++ +G Y C + + +D + L V+ PPQ PP +
Sbjct: 2217 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQD-------LQLEVHVPPQIAGPREPPTQVS 2269
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTC 206
V + TL C A G P P VTW+ G+ +G G Q+Q Q +L + R + +G Y+C
Sbjct: 2270 VVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 2329
Query: 207 QASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
A + G A +L VL PP ++ P N T ++L C A P WF+
Sbjct: 2330 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP-AIRWFR 2388
Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPA 323
V S + + L++ TQ D+G Y+C+ SN + + VL P
Sbjct: 2389 GEEPV---SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNE-AGEARRNFSVEVLVPP 2444
Query: 324 QVTAMPPETPLPI--GMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSL 380
+ E + + G + C V +P P L +W KDG+ L + +G L
Sbjct: 2445 SIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFKDGRPLA--RGDAHHISPDGVL 2500
Query: 381 IIAL-GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF---IERPKEEYFQEVGREL 436
+ L N + G YSC N++G VLL AP + EE V +
Sbjct: 2501 LQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLL-APTILGGAEDSADEEVTVTVNNPI 2559
Query: 437 LIPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNAVA 493
+ C A P P ++W K G + + L + KE G + C +N +
Sbjct: 2560 SLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 2619
Query: 494 RVATSTNVYVL 504
+ +V VL
Sbjct: 2620 EAVKNYHVEVL 2630
Score = 103 bits (258), Expect = 7e-22
Identities = 106/367 (28%), Positives = 154/367 (41%), Gaps = 28/367 (7%)
Query: 152 EPVTLRCVARGSPLPHVTWKLRGKD-LGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASS 210
+P+ + C S LP RG+ LG+ + + N + I R + G Y C A S
Sbjct: 442 QPLLVSCSVH-SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 500
Query: 211 TEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACH--AEAYPANLTYSWFQDNINV 268
G+ Q++V PP +VP N TV+ + L+C EA P NLT W +D
Sbjct: 501 RAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA-PYNLT--WVRD---- 553
Query: 269 FHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQ 324
R+ P RV L D SL + P D G Y CV SN AS +L V Q
Sbjct: 554 ---WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA-NGVTRASVWLLVREAPQ 609
Query: 325 VTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII-A 383
V+ G+ + C + P +SW+++ +ALQ D +G+LII
Sbjct: 610 VSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISWSRESQALQEDS--RIHVDAQGTLIIQG 666
Query: 384 LGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQ 443
+ EDA G YSC N +GT T L P + VG E ++ C A
Sbjct: 667 VAPEDA-GNYSCQATNEVGT---DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEAS 722
Query: 444 GDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYV 503
G PPP V W + G + + S+ L + + G + C A N + + + V
Sbjct: 723 GVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 782
Query: 504 LGTSPHV 510
G +P +
Sbjct: 783 -GHAPQL 788
Score = 102 bits (253), Expect = 3e-21
Identities = 133/525 (25%), Positives = 206/525 (39%), Gaps = 77/525 (14%)
Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPP--AGRPPLHVIEWLRFGFLLPIFIQF 70
V+ + + P+++ G + ++G L P A P+ I+WL+ G
Sbjct: 1677 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--------- 1727
Query: 71 GLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHL 130
R + G +G +L I+ + ++ G + C+ + G+ V +
Sbjct: 1728 -----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA-------TNEAGTAGAEVEV 1775
Query: 131 TVNSPPQFQETPPAVLEV---------QELEPVTLRC---VARG---SPLPHVT--WKLR 173
+V+ E P VLEV + C V RG P P + W
Sbjct: 1776 SVHG-----EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSP 1830
Query: 174 GKDLGQGQGQVQVQN--GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVV 231
G G+ G + L+I +V+ G+YTC A++ G + L VL PP I
Sbjct: 1831 GSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP 1890
Query: 232 PPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLA 290
P N V + V+L C A P SWF+ + V V + VDG LR+
Sbjct: 1891 GPVNKAVLENASVTLECLASGVPPP-DVSWFKGHQPV----SSWMGVTVSVDGRVLRIEQ 1945
Query: 291 TQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPG--VIRCPVR- 347
Q DAG Y CV SN + + Y +V +PP LP +PG ++ PVR
Sbjct: 1946 AQLSDAGSYRCVASN-------VAGSTELRYGLRVN-VPPRITLPPSLPGPVLVNTPVRL 1997
Query: 348 ----ANPPLLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLG 402
P + W KDG + PG G L +A G YSC +++G
Sbjct: 1998 TCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG 2057
Query: 403 TAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE-LLIPCSAQGDPPPVVSWTKVGRGLQG 461
V +V + PP+ + +E V E + + C + PPPV+SW K GR L+
Sbjct: 2058 EDRQDVVLQVHM--PPSIL--GEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEP 2113
Query: 462 QAQVDSNSSLILRPLTKE---AHGHWECSASNAVARVATSTNVYV 503
+ V ++ L + + GH+ C A N N+ V
Sbjct: 2114 RPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV 2158
Score = 101 bits (251), Expect = 5e-21
Identities = 219/890 (24%), Positives = 320/890 (35%), Gaps = 141/890 (15%)
Query: 14 ISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLY 73
+ G G + + G A VLG + PP +P V++ L L + G
Sbjct: 1089 VQVGDSGHYECTASNPAGSASHRYVLGVQV-PPQVQPGPRVLKVLVGEALDLNCVAEGNP 1147
Query: 74 SPRIDPDYVGRVRLQKG--ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHL 130
P++ G V +G S+ +R D G Y C + +W V L
Sbjct: 1148 EPQLSWSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEA--------SNSAGVDAWEVEL 1199
Query: 131 TVNSPPQF-QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKL--RGKDLGQGQGQVQVQ 187
V PP + + +LE E +L C ARG+P P VTW+ + L G ++
Sbjct: 1200 RVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLE 1259
Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN--ASQDVS 245
G+L + V SG Y CQA++ GS + +L+V PP I + + V+ A Q ++
Sbjct: 1260 EGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLT 1319
Query: 246 LACHAEAYPANLTYSWFQDNINV----------FHISRLQPRVRILVD--GSLRLLATQP 293
L C A +P W +D V + + Q L+D SL Q
Sbjct: 1320 LECDANGFPVP-EIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQE 1378
Query: 294 DDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGV---IRCPVRANP 350
D+G Y+C N +L VL P V + +G+ G ++C +
Sbjct: 1379 GDSGLYSCRAEN-QAGTAQRDFHLLVLTPPSVLGAGAAQEV-LGLAGADVELQC-WTSGV 1435
Query: 351 PLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNE-DALGEYSCTPYNSLGTAGPSPV 409
P V WTKD + + L P +G ++ G+ G Y C ++ G
Sbjct: 1436 PTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQ 1494
Query: 410 TRVLLKAPPAFIERPKEEYFQEVGRELLIP--CSAQGDPPPVVSWTKVGRGLQGQAQV-- 465
RV APP I E V + L+ C A+G P P ++W K G L +V
Sbjct: 1495 LRV--HAPPT-IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVY 1551
Query: 466 -DSNSSLILRPLTKEAHGHWECSASNAV--ARVATSTNVYVLGTSPHVVTNVSVVALPKG 522
L L G + C ASNAV A AT +VYV T VV G
Sbjct: 1552 TRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAG 1611
Query: 523 ANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQF 582
V+ E G S W HH+ +PV ++ + +
Sbjct: 1612 RPVALECVARGHPSPTLS-W-----------HHE----GLPVAESN------ESRLETDG 1649
Query: 583 SVL---AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGV 639
SVL + + SG +S V S+P G + ++PP L GL V T G
Sbjct: 1650 SVLRLESPGEASSGLYS-CVASSPAGEAVLQYS---VEVQVPPQLLVAEGLGQVTTIVG- 1704
Query: 640 LLHWDPPELVPKRLDGYVLEGRQ----GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFR 695
P EL P + G + Q G E+ VA T L + + D
Sbjct: 1705 ----QPLEL-PCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELD------ 1753
Query: 696 LVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSIL 755
+G F +N A + + +EV PG+L P+ G G S
Sbjct: 1754 ---HSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPI------GQYHWGXEHHSSFP 1804
Query: 756 AGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLR 815
A C DPP+ P G SP S
Sbjct: 1805 AAC-----------------DPPVHRGWGAHPKPPLVEGWCSPGS--------------- 1832
Query: 816 QSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQER 865
LWG+P G P + PP PL +E + +G + T A + +
Sbjct: 1833 ---LWGEPTGIPVAYSLPP----PLQIEKVDLRDEGIYTCAATNLAGESK 1875
Score = 100 bits (249), Expect = 8e-21
Identities = 116/434 (26%), Positives = 168/434 (38%), Gaps = 43/434 (9%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH--LTVNSPPQFQETPPAVLE 147
G L+IE ++ D G Y C + A + + L VN PP+ P
Sbjct: 1938 GRVLRIEQAQLSDAGSYRCVA---------SNVAGSTELRYGLRVNVPPRITLPPSLPGP 1988
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQVQNG--TLRIRRVERGSSGVY 204
V PV L C A G+P P + W G + G +QV G L + SG Y
Sbjct: 1989 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 2048
Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
+C A S G L V PP I+ N +V A++ V+L C + A P + SW++D
Sbjct: 2049 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKD 2107
Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPD---DAGCYTCVPSNGLLHPPSASAYLTVLY 321
L+PR + + LL DAG YTC N H S Y ++
Sbjct: 2108 G------RPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGH--SEKHYNLNVW 2159
Query: 322 PAQVTAMPPETPLPI--GMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG- 378
A V + L + G P + C R P +SW KDG+ L PG G +
Sbjct: 2160 VAPVFPLRESHTLTVREGHPTSLSCECR-GVPFPKISWRKDGQPL-----PGEGAGLQHV 2213
Query: 379 ---SLIIALGNEDAL--GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG 433
++ LG G Y+C N +G + V + A P +
Sbjct: 2214 SAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQD 2273
Query: 434 RELLIPCSAQGDPPPVVSWTKVGR--GLQGQAQVDSNSSLILRPLTKEAH-GHWECSASN 490
+ C+A G PPP V+W + G+ G + Q+ + + + AH G + C A N
Sbjct: 2274 GVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN 2333
Query: 491 AVARVATSTNVYVL 504
R + VL
Sbjct: 2334 LAGRAERKFELSVL 2347
Score = 97.1 bits (240), Expect = 9e-20
Identities = 114/394 (28%), Positives = 157/394 (39%), Gaps = 53/394 (13%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH---LTVNSPPQFQETPP 143
L SL++ ++V D G YEC GS H L V PPQ Q P
Sbjct: 1078 LLPSGSLRLAQVQVGDSGHYECTA----------SNPAGSASHRYVLGVQVPPQVQ-PGP 1126
Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGV 203
VL+V E + L CVA G+P P ++W G L QG+G G++ + +G
Sbjct: 1127 RVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVL-QGRG----PQGSVHFAAIRTSDAGR 1181
Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN--ASQDVSLACHAEAYPANLTYSW 261
Y C+AS++ G +L VL PP + + A ++ SL C A P
Sbjct: 1182 YRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWR 1241
Query: 262 FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLY 321
+ H QP V +L +GSL L + P D+G Y C +N + S A L V
Sbjct: 1242 KGPSSEPLH---GQPGVAVLEEGSLFLASVSPADSGDYECQATNE-VGSTSRRAKLVVYV 1297
Query: 322 PAQVTAMPPETPLPIGMPG---VIRCPVRANPPLLFVSWTKDGKALQLDKFP------GW 372
P + + + GM G + C P+ + W KD QL P GW
Sbjct: 1298 PPSIREDGRKANVS-GMAGQSLTLECDANGF-PVPEIVWLKDA---QLVGVPLGWAGYGW 1352
Query: 373 SQG----------TEG-SLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 421
G EG SL E G YSC N GTA +L+ PP+ +
Sbjct: 1353 DLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRD--FHLLVLTPPSVL 1410
Query: 422 -ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTK 454
+E G ++ + C G P P V WTK
Sbjct: 1411 GAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK 1444
Score = 96.3 bits (238), Expect = 2e-19
Identities = 128/513 (24%), Positives = 196/513 (38%), Gaps = 67/513 (13%)
Query: 16 QGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSP 75
Q A R P VSVV L C+ G+PP + W R G P+ + GL
Sbjct: 2257 QIAGPREPPTQVSVVQDG--VATLECNA---TGKPP-PTVTWERDG--QPVGAELGL--- 2305
Query: 76 RIDPDYVGRVRLQ-KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNS 134
+LQ +G SL +E + G Y C L L+V
Sbjct: 2306 ----------QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK-------FELSVLV 2348
Query: 135 PPQF--QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TL 191
PP+ P + P+TL C A G P P + W + + G+ + G L
Sbjct: 2349 PPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWML 2408
Query: 192 RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA--SQDVSLACH 249
++ + + SG+Y+C AS+ G A + VL PP I + Q L C+
Sbjct: 2409 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 2468
Query: 250 AEAYPANLTYSWFQDNI-----NVFHISRLQPRVRILVDGSL-RLLATQPDDAGCYTCVP 303
+P +WF+D + HIS DG L ++L AG Y+C+
Sbjct: 2469 VTGHPQP-KLTWFKDGRPLARGDAHHISP---------DGVLLQVLQANLSSAGHYSCIA 2518
Query: 304 SNGLLHPPSASAYLTVLYPAQV----TAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTK 359
+N + +L P + + E + + P + C A P ++W K
Sbjct: 2519 ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPN-ITWMK 2577
Query: 360 DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 419
DG + + GT G I+ EDA G+Y+C N LG A + VL+ PP+
Sbjct: 2578 DGAPFEASRNIQLLPGTHGLQILNAQKEDA-GQYTCVVTNELGEAVKNYHVEVLI--PPS 2634
Query: 420 FI------ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSL 471
E +E +V L + C + PPP + W K G+ + + QV L
Sbjct: 2635 ISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL 2694
Query: 472 I-LRPLTKEAHGHWECSASNAVARVATSTNVYV 503
+ ++P G + C A+N NV +
Sbjct: 2695 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 2727
Score = 93.2 bits (230), Expect = 1e-18
Identities = 132/493 (26%), Positives = 186/493 (37%), Gaps = 100/493 (20%)
Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88
V+ GE VL C+ +G PP VI W R G + +
Sbjct: 707 VLVAVGEEAVLVCEA---SGVPPPRVI-WYRGGLEM--------------------ILAP 742
Query: 89 KGAS---LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAV 145
+G+S L+I + D G Y CR + E A+ + L V PQ E P V
Sbjct: 743 EGSSSGKLRIPAAQERDAGTYTCRA------VNELGDASAE-IQLAVGHAPQLTELPRDV 795
Query: 146 LEVQELEPVTLRCVARGSPLPHVTWKLR-----GKDLGQGQGQV--QVQNGTLRIRRVER 198
V+ L C A G P P VTW+ G LG G+G Q +G L V
Sbjct: 796 T-VELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAP 854
Query: 199 GSSGVYTCQASSTEGSATHATQLLVLG--PPVIVVPPKNSTVNASQDVSLACHAEAYPAN 256
Y C+A + G +L+V G PP I V Q VSL C A
Sbjct: 855 EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 914
Query: 257 LTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSN--GLLHPPS 312
W +D L P R I DGSL L + AG Y+CV +N G H
Sbjct: 915 PERHWLKDG------RPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQH--- 965
Query: 313 ASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGW 372
L V P ++ G+P + C V + P ++WTK+ AL + P +
Sbjct: 966 RDVELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVPAPTITWTKETNALT-SRGPHY 1023
Query: 373 SQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV 432
+ EG+L+IA + G Y CT N++G + V A ++ ++E
Sbjct: 1024 NVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYV-------WEEY 1076
Query: 433 GRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAV 492
G L+P + SL L + GH+EC+ASN
Sbjct: 1077 G---LLP----------------------------SGSLRLAQVQVGDSGHYECTASNP- 1104
Query: 493 ARVATSTNVYVLG 505
++++ YVLG
Sbjct: 1105 --AGSASHRYVLG 1115
Score = 92.4 bits (228), Expect = 2e-18
Identities = 97/345 (28%), Positives = 141/345 (40%), Gaps = 36/345 (10%)
Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
+G+LR+ +V+ G SG Y C AS+ GSA+H L V PP + P+ V + + L
Sbjct: 1081 SGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLN 1140
Query: 248 CHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL 307
C AE P SW +D + LQ R GS+ A + DAG Y C SN
Sbjct: 1141 CVAEGNP-EPQLSWSKDGV------VLQGRG---PQGSVHFAAIRTSDAGRYRCEASNS- 1189
Query: 308 LHPPSASAYLTVLYPAQVTAMPPETPLP--IGMPGVIRCPVRANPPLLFVSWTKDGKALQ 365
+ L VL P A L G + CP R P V+W K +
Sbjct: 1190 AGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQ-VTWRKGPSSEP 1248
Query: 366 LDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPK 425
L PG + EGSL +A + G+Y C N +G+ S ++++ PP+ E +
Sbjct: 1249 LHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST--SRRAKLVVYVPPSIREDGR 1306
Query: 426 EEYFQEV-GRELLIPCSAQGDPPPVVSWTK-----------VGRG-------LQGQAQVD 466
+ + G+ L + C A G P P + W K G G + G +D
Sbjct: 1307 KANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLD 1366
Query: 467 SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVV 511
SL + + G + C A N ++ VL T P V+
Sbjct: 1367 EGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVL-TPPSVL 1410
Score = 63.9 bits (154), Expect = 8e-10
Identities = 48/145 (33%), Positives = 68/145 (46%), Gaps = 11/145 (7%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTV-NSPPQFQETP 142
R +LQ G SL I +D G Y+C + E++ V + V S P FQ
Sbjct: 4265 RHQLQNG-SLTIHRTERDDAGRYQC--------LAENEMGVAKKVVILVLQSAPVFQ-VE 4314
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202
P + V+ + V LRC A G P P + W G+ L + + +G+L + VE G +G
Sbjct: 4315 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 4374
Query: 203 VYTCQASSTEGSATHATQLLVLGPP 227
Y C A + GSAT L+V G P
Sbjct: 4375 TYDCVAHNLLGSATARAFLVVRGEP 4399
Score = 58.5 bits (140), Expect = 4e-08
Identities = 98/443 (22%), Positives = 159/443 (35%), Gaps = 64/443 (14%)
Query: 93 LQIEGLRVEDQGWYECRVFF-LDQHIPEDDFANGSWVHLTVNSPPQFQETPP----AVLE 147
LQI + ED G Y C V L + + H+ V PP + P V E
Sbjct: 2597 LQILNAQKEDAGQYTCVVTNELGEAVKN--------YHVEVLIPPSISKDDPLGEVGVKE 2648
Query: 148 VQEL--EPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVY 204
V+ +TL C + P P + W G+ + QV + L+I+ + SG Y
Sbjct: 2649 VKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRY 2708
Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNST--------------------VNASQDV 244
C A++ G +L+ PP+ S + +
Sbjct: 2709 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 2768
Query: 245 SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVP 303
L C A P +W++++ + V +L G L++ + ++AG Y+C
Sbjct: 2769 YLYCDTNAIPPP-DLTWYREDQPL----SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKA 2823
Query: 304 SNGL----LHPPSASAYLTVLYPAQVTA----MPPETPLPIGMPGVIRCPVRANPPLLFV 355
SN + LH L VL P + + E + ++CP N P+ +
Sbjct: 2824 SNEVGEDWLH-----YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN-PVPTI 2877
Query: 356 SWTKDGKALQLDKFPGWSQGTEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLL 414
SW ++G L P +G ++ ++ Y C N G+A RV
Sbjct: 2878 SWLQNG--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV-- 2933
Query: 415 KAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSL 471
+ PP E+ + + +PC P P V+W K + L +V +L
Sbjct: 2934 QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTL 2993
Query: 472 ILRPLTKEAHGHWECSASNAVAR 494
L G + C A NA R
Sbjct: 2994 QLGRARLSDSGMYTCEALNAAGR 3016
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 125 bits (313), Expect = 3e-28
Identities = 142/502 (28%), Positives = 203/502 (40%), Gaps = 73/502 (14%)
Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88
V+ GE VL C+ +G PP VI W R G + +
Sbjct: 590 VLVAVGEEAVLVCEA---SGVPPPRVI-WYRGGLEM--------------------ILAP 625
Query: 89 KGAS---LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAV 145
+G+S L+I + D G Y CR + E A+ + L V PQ E P V
Sbjct: 626 EGSSSGKLRIPAAQERDAGTYTCRA------VNELGDASAE-IQLAVGHAPQLTELPRDV 678
Query: 146 LEVQELEPVTLRCVARGSPLPHVTWKLR-----GKDLGQGQGQV--QVQNGTLRIRRVER 198
V+ L C A G P P VTW+ G LG G+G Q +G L V
Sbjct: 679 T-VELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAP 737
Query: 199 GSSGVYTCQASSTEGSATHATQLLVLG--PPVIVVPPKNSTVNASQDVSLACHAEAYPAN 256
Y C+A + G +L+V G PP I V Q VSL C A
Sbjct: 738 EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 797
Query: 257 LTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSN--GLLHPPS 312
W +D L P R I DGSL L + AG Y+CV +N G H
Sbjct: 798 PERHWLKDG------RPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQH--- 848
Query: 313 ASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGW 372
L V P ++ G+P + C V + P ++WTK+ AL + P +
Sbjct: 849 RDVELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVPAPTITWTKETNALT-SRGPHY 906
Query: 373 SQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKE------ 426
+ EG+L+IA + G Y CT N++G + S R+ + P
Sbjct: 907 NVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS--SQEMRLSVNTKPRIHMNGSRNANVPL 964
Query: 427 EYFQEVGRELLIPCSAQGDPPPVVSWTKVGR---GLQGQAQVDSNSSLILRPLTKEAHGH 483
+ + G E+ + C A+G PPP+V+WTK R + + + + SL L + GH
Sbjct: 965 QVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGH 1024
Query: 484 WECSASNAVARVATSTNVYVLG 505
+EC+ASN ++++ YVLG
Sbjct: 1025 YECTASNP---AGSASHRYVLG 1043
Score = 115 bits (287), Expect = 3e-25
Identities = 141/535 (26%), Positives = 203/535 (37%), Gaps = 70/535 (13%)
Query: 14 ISQGADGRGKPEVV------------SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFG 61
+S+ GR K ++V +V GE+ VL C +L G P + + W+R
Sbjct: 382 VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL---GEAPYN-LTWVR-- 435
Query: 62 FLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDD 121
R+ P GRV SL+I G+ D G Y+C
Sbjct: 436 ------------DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVA----------S 473
Query: 122 FANG---SWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLG 178
ANG + V L V PQ + Q +E V + C A G P PH++W + L
Sbjct: 474 NANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE-VKVSCSASGYPTPHISWSRESQAL- 531
Query: 179 QGQGQVQVQ-NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNST 237
Q ++ V GTL I+ V +G Y+CQA++ G+ L PP +
Sbjct: 532 QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 591
Query: 238 VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAG 297
V ++ L C A P W++ + + L P G LR+ A Q DAG
Sbjct: 592 VAVGEEAVLVCEASGVPPPRVI-WYRGGLEMI----LAPEGS--SSGKLRIPAAQERDAG 644
Query: 298 CYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSW 357
YTC N L SA L V + Q+T +P + + +G ++ C PP V+W
Sbjct: 645 TYTCRAVNE-LGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPT-VTW 702
Query: 358 TK-DGKALQLDKFPGWS----QGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRV 412
+ DG+ L L G Q G L + Y C N G V
Sbjct: 703 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
Query: 413 LLKAPPAFIERPKEEYFQEVGRELLIPCSA-QGDPPPVVSWTKVGRGLQ--GQAQVDSNS 469
APP E G+ + +PC G P P W K GR L + + ++
Sbjct: 763 TGHAPPQIASSAPTVRVLE-GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG 821
Query: 470 SLILRPLTKEAHGHWECSASNAVARVATSTNVYVL------GTSPHVVTNVSVVA 518
SL L +E G + C A+N + V T+ H +TN V A
Sbjct: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPA 876
Score = 103 bits (258), Expect = 7e-22
Identities = 106/367 (28%), Positives = 154/367 (41%), Gaps = 28/367 (7%)
Query: 152 EPVTLRCVARGSPLPHVTWKLRGKD-LGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASS 210
+P+ + C S LP RG+ LG+ + + N + I R + G Y C A S
Sbjct: 325 QPLLVSCSVH-SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 383
Query: 211 TEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACH--AEAYPANLTYSWFQDNINV 268
G+ Q++V PP +VP N TV+ + L+C EA P NLT W +D
Sbjct: 384 RAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA-PYNLT--WVRD---- 436
Query: 269 FHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQ 324
R+ P RV L D SL + P D G Y CV SN AS +L V Q
Sbjct: 437 ---WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA-NGVTRASVWLLVREAPQ 492
Query: 325 VTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII-A 383
V+ G+ + C + P +SW+++ +ALQ D +G+LII
Sbjct: 493 VSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISWSRESQALQEDS--RIHVDAQGTLIIQG 549
Query: 384 LGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQ 443
+ EDA G YSC N +GT T L P + VG E ++ C A
Sbjct: 550 VAPEDA-GNYSCQATNEVGT---DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEAS 605
Query: 444 GDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYV 503
G PPP V W + G + + S+ L + + G + C A N + + + V
Sbjct: 606 GVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 665
Query: 504 LGTSPHV 510
G +P +
Sbjct: 666 -GHAPQL 671
Score = 53.5 bits (127), Expect = 1e-06
Identities = 36/105 (34%), Positives = 54/105 (51%), Gaps = 7/105 (6%)
Query: 128 VHLTVNSPPQFQ------ETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQ 181
+ L+VN+ P+ P + + E VTL C A+GSP P VTW + +
Sbjct: 942 MRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT 1001
Query: 182 GQVQV-QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLG 225
+ + +G+LR+ +V+ G SG Y C AS+ GSA+H L V G
Sbjct: 1002 NRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQG 1046
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 124 bits (312), Expect = 4e-28
Identities = 174/703 (24%), Positives = 279/703 (39%), Gaps = 72/703 (10%)
Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGL 72
++++GA K V V GESVVL C+ PP PL + W+ L
Sbjct: 125 LMAEGAPKWPKETVKPVEVEEGESVVLPCN--PPPSAEPLRIY-WMNSKIL--------- 172
Query: 73 YSPRIDPDYVGRVRLQKGASLQIEGLRVEDQ-GWYECRVFF-----LDQHIPEDDFANGS 126
I D RV + + +L + D Y C F + Q P D +
Sbjct: 173 ---HIKQDE--RVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKAT 227
Query: 127 WVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV 186
+ F + L + +P+ L C+A G P P + W + + Q
Sbjct: 228 NSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQN 287
Query: 187 QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246
N TL++ +V G Y C A ++ GSA HA + V P + P++ + L
Sbjct: 288 HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARL 347
Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN- 305
C + P +W + I V +++ Q + RI G+L L QP D C N
Sbjct: 348 DCQVQGRP-QPEVTWRINGIPVEELAKDQ-KYRI-QRGALILSNVQPSDTMVTQCEARNR 404
Query: 306 -GLLHPPSASAYLTVL-YPAQVTAMPPETPLPI-GMPGVIRCPVRANPPLLFVSW-TKDG 361
GLL A+AY+ V+ PA++ +T + + G + C P+ V W +DG
Sbjct: 405 HGLL---LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKA-FGAPVPSVQWLDEDG 460
Query: 362 -KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF 420
LQ ++F ++ GT G I L D G Y C N + + + +K
Sbjct: 461 TTVLQDERFFPYANGTLG--IRDLQANDT-GRYFCLAANDQNNV--TIMANLKVKDATQI 515
Query: 421 IERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD----SNSSLILR 474
+ P+ ++ G + C A DP P ++W GR LQ D + L++
Sbjct: 516 TQGPRST-IEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIH 574
Query: 475 PLTKEAHGHWECSASNAVARVATSTNVYVLGTS---PHVVTNVSVVALPKGANVSWEPGF 531
L G++ C AS + V + + V+G+ P +V + + VSW P
Sbjct: 575 SLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAE 634
Query: 532 D-GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKL 590
D ++++ + + P++ W SL G L P+ Y F V A NK
Sbjct: 635 DHNAPIEKYDIEFEDKEMAPEK----WYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKY 690
Query: 591 GSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVP 650
G G S + E + T AAP P ++ + +V P + W+ P++
Sbjct: 691 GPGEPSPV----SETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLR-WMDWNAPQV-- 743
Query: 651 KRLDGYVLEGR-QGSQG-WE---VLDPAVAGTETELLVPGLIK 688
Y ++ R QG++G W+ V DP + + T VP IK
Sbjct: 744 ----QYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIK 782
Score = 86.7 bits (213), Expect = 1e-16
Identities = 136/575 (23%), Positives = 217/575 (37%), Gaps = 57/575 (9%)
Query: 156 LRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGS 214
L C A G+P+P V W G + Q + NGTL IR ++ +G Y C A++ + +
Sbjct: 441 LLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNN 500
Query: 215 ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA-NLTYSWFQDNINVFHISR 273
T L V I P+++ V+ C A P+ + +W D ++ +
Sbjct: 501 VTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGD 560
Query: 274 LQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETP 333
+ DG L + + D G Y+CV S L S + L V P V +
Sbjct: 561 SDKY--FIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDL 618
Query: 334 --LPIGMPGVIRCPVRA-NPPLLFVSWTKDGKALQLDKFP--GWSQGTEGSLIIALGNED 388
L V P N P+ + K + +K+ G G + S + L +
Sbjct: 619 HLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKL-SPY 677
Query: 389 ALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE---LLIPCSA--- 442
+ T N G PSPV+ ++ A + P + + G E ++I
Sbjct: 678 VHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVD--VKGEGNETTNMVITWKPLRW 735
Query: 443 -QGDPPPV---VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATS 498
+ P V V W G Q Q+ S+ L++ + + A N+ +
Sbjct: 736 MDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEP 795
Query: 499 --TNVYVLGTSPHVVTNVSVVALPKGANV--SWEP---GFDGGYLQRFSV--WYTPLAKR 549
T Y P + + + + + V W P G+L+ ++V W ++
Sbjct: 796 QVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRK 855
Query: 550 PDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTT 609
+ H + VP +++ GL+P++ Y V A N GSGP SE S PEG+P
Sbjct: 856 HSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGH 915
Query: 610 PAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVL------EGRQG 663
P A L ++ +LL W PP L GYVL EG +G
Sbjct: 916 PEALHL----------------ECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKG 959
Query: 664 SQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 698
+ + DP + L P L Y F+L A
Sbjct: 960 QLSFNLRDPELRTHNLTDLSPHL----RYRFQLQA 990
Score = 66.2 bits (160), Expect = 2e-10
Identities = 96/425 (22%), Positives = 158/425 (37%), Gaps = 75/425 (17%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRG------KDLGQGQGQVQVQN 188
PP E P L V + ++L+C A G P W G ++LG Q +
Sbjct: 29 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQ-SPHS 87
Query: 189 GTLRI----RRVERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNST----VN 239
G+ I + G+Y C AS+ G+A +H +L+ G P PK + V
Sbjct: 88 GSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW---PKETVKPVEVE 144
Query: 240 ASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLR----LLATQPDD 295
+ V L C+ L W N + HI + RV + +G+L L + D
Sbjct: 145 EGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQ-DERVTMGQNGNLYFANVLTSDNHSD 201
Query: 296 AGCYTCVPSN------------------------GLLHPPSASAYLTVLYPAQVTAMPPE 331
C+ P LL P ++S++L L
Sbjct: 202 YICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQ---------- 251
Query: 332 TPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALG 391
G P V+ C + P + W + + D+ + + ++ +G ED G
Sbjct: 252 -----GQPLVLEC-IAEGFPTPTIKWLRPSGPMPADRVT-YQNHNKTLQLLKVGEEDD-G 303
Query: 392 EYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVS 451
EY C NSLG+A V ++A P ++ +P+ + G + C QG P P V+
Sbjct: 304 EYRCLAENSLGSA--RHAYYVTVEAAPYWLHKPQSHLYGP-GETARLDCQVQGRPQPEVT 360
Query: 452 WTKVGRGLQGQAQVD----SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTS 507
W G ++ A+ +LIL + +C A N + + +YV+
Sbjct: 361 WRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLP 420
Query: 508 PHVVT 512
++T
Sbjct: 421 AKILT 425
Score = 50.1 bits (118), Expect = 1e-05
Identities = 67/293 (22%), Positives = 113/293 (38%), Gaps = 28/293 (9%)
Query: 223 VLGPPVIVVP-PKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRV-RI 280
++ PPVI P+ V + D+SL C A P + + W +D ++ L V +
Sbjct: 26 LMEPPVITEQSPRRLVVFPTDDISLKCEASGKP-EVQFRWTRDGVHFKPKEELGVTVYQS 84
Query: 281 LVDGSLRLLATQPDDA----GCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPI 336
GS + + A G Y C SN L +A ++ L P ET P+
Sbjct: 85 PHSGSFTITGNNSNFAQRFQGIYRCFASNKL---GTAMSHEIRLMAEGAPKWPKETVKPV 141
Query: 337 GMPGVIRCPVRANPPL----LFVSWTKDGKALQLDKFPGWSQGTEGSLIIA-LGNEDALG 391
+ + NPP L + W + K L + + + G G+L A + D
Sbjct: 142 EVEEGESVVLPCNPPPSAEPLRIYWM-NSKILHIKQDERVTMGQNGNLYFANVLTSDNHS 200
Query: 392 EYSC-TPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQE---------VGRELLIPCS 441
+Y C + T + +KA + I+R F G+ L++ C
Sbjct: 201 DYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECI 260
Query: 442 AQGDPPPVVSWTKVGRGLQGQ--AQVDSNSSLILRPLTKEAHGHWECSASNAV 492
A+G P P + W + + + N +L L + +E G + C A N++
Sbjct: 261 AEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSL 313
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 124 bits (312), Expect = 4e-28
Identities = 174/703 (24%), Positives = 279/703 (39%), Gaps = 72/703 (10%)
Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGL 72
++++GA K V V GESVVL C+ PP PL + W+ L
Sbjct: 130 LMAEGAPKWPKETVKPVEVEEGESVVLPCN--PPPSAEPLRIY-WMNSKIL--------- 177
Query: 73 YSPRIDPDYVGRVRLQKGASLQIEGLRVEDQ-GWYECRVFF-----LDQHIPEDDFANGS 126
I D RV + + +L + D Y C F + Q P D +
Sbjct: 178 ---HIKQDE--RVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKAT 232
Query: 127 WVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV 186
+ F + L + +P+ L C+A G P P + W + + Q
Sbjct: 233 NSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQN 292
Query: 187 QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246
N TL++ +V G Y C A ++ GSA HA + V P + P++ + L
Sbjct: 293 HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARL 352
Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN- 305
C + P +W + I V +++ Q + RI G+L L QP D C N
Sbjct: 353 DCQVQGRP-QPEVTWRINGIPVEELAKDQ-KYRI-QRGALILSNVQPSDTMVTQCEARNR 409
Query: 306 -GLLHPPSASAYLTVL-YPAQVTAMPPETPLPI-GMPGVIRCPVRANPPLLFVSW-TKDG 361
GLL A+AY+ V+ PA++ +T + + G + C P+ V W +DG
Sbjct: 410 HGLL---LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKA-FGAPVPSVQWLDEDG 465
Query: 362 -KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF 420
LQ ++F ++ GT G I L D G Y C N + + + +K
Sbjct: 466 TTVLQDERFFPYANGTLG--IRDLQANDT-GRYFCLAANDQNNV--TIMANLKVKDATQI 520
Query: 421 IERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD----SNSSLILR 474
+ P+ ++ G + C A DP P ++W GR LQ D + L++
Sbjct: 521 TQGPRST-IEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIH 579
Query: 475 PLTKEAHGHWECSASNAVARVATSTNVYVLGTS---PHVVTNVSVVALPKGANVSWEPGF 531
L G++ C AS + V + + V+G+ P +V + + VSW P
Sbjct: 580 SLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAE 639
Query: 532 D-GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKL 590
D ++++ + + P++ W SL G L P+ Y F V A NK
Sbjct: 640 DHNAPIEKYDIEFEDKEMAPEK----WYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKY 695
Query: 591 GSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVP 650
G G S + E + T AAP P ++ + +V P + W+ P++
Sbjct: 696 GPGEPSPV----SETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLR-WMDWNAPQV-- 748
Query: 651 KRLDGYVLEGR-QGSQG-WE---VLDPAVAGTETELLVPGLIK 688
Y ++ R QG++G W+ V DP + + T VP IK
Sbjct: 749 ----QYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIK 787
Score = 86.7 bits (213), Expect = 1e-16
Identities = 136/575 (23%), Positives = 217/575 (37%), Gaps = 57/575 (9%)
Query: 156 LRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGS 214
L C A G+P+P V W G + Q + NGTL IR ++ +G Y C A++ + +
Sbjct: 446 LLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNN 505
Query: 215 ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA-NLTYSWFQDNINVFHISR 273
T L V I P+++ V+ C A P+ + +W D ++ +
Sbjct: 506 VTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGD 565
Query: 274 LQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETP 333
+ DG L + + D G Y+CV S L S + L V P V +
Sbjct: 566 SDKY--FIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDL 623
Query: 334 --LPIGMPGVIRCPVRA-NPPLLFVSWTKDGKALQLDKFP--GWSQGTEGSLIIALGNED 388
L V P N P+ + K + +K+ G G + S + L +
Sbjct: 624 HLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKL-SPY 682
Query: 389 ALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE---LLIPCSA--- 442
+ T N G PSPV+ ++ A + P + + G E ++I
Sbjct: 683 VHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVD--VKGEGNETTNMVITWKPLRW 740
Query: 443 -QGDPPPV---VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATS 498
+ P V V W G Q Q+ S+ L++ + + A N+ +
Sbjct: 741 MDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEP 800
Query: 499 --TNVYVLGTSPHVVTNVSVVALPKGANV--SWEP---GFDGGYLQRFSV--WYTPLAKR 549
T Y P + + + + + V W P G+L+ ++V W ++
Sbjct: 801 QVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRK 860
Query: 550 PDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTT 609
+ H + VP +++ GL+P++ Y V A N GSGP SE S PEG+P
Sbjct: 861 HSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGH 920
Query: 610 PAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVL------EGRQG 663
P A L ++ +LL W PP L GYVL EG +G
Sbjct: 921 PEALHL----------------ECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKG 964
Query: 664 SQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 698
+ + DP + L P L Y F+L A
Sbjct: 965 QLSFNLRDPELRTHNLTDLSPHL----RYRFQLQA 995
Score = 67.0 bits (162), Expect = 1e-10
Identities = 97/428 (22%), Positives = 159/428 (37%), Gaps = 75/428 (17%)
Query: 132 VNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRG------KDLGQGQGQVQ 185
V PP E P L V + ++L+C A G P W G ++LG Q
Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQ-S 89
Query: 186 VQNGTLRI----RRVERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNST--- 237
+G+ I + G+Y C AS+ G+A +H +L+ G P PK +
Sbjct: 90 PHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW---PKETVKPV 146
Query: 238 -VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLR----LLATQ 292
V + V L C+ L W N + HI + RV + +G+L L +
Sbjct: 147 EVEEGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQ-DERVTMGQNGNLYFANVLTSDN 203
Query: 293 PDDAGCYTCVPSN------------------------GLLHPPSASAYLTVLYPAQVTAM 328
D C+ P LL P ++S++L L
Sbjct: 204 HSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQ------- 256
Query: 329 PPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNED 388
G P V+ C + P + W + + D+ + + ++ +G ED
Sbjct: 257 --------GQPLVLEC-IAEGFPTPTIKWLRPSGPMPADRVT-YQNHNKTLQLLKVGEED 306
Query: 389 ALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPP 448
GEY C NSLG+A V ++A P ++ +P+ + G + C QG P P
Sbjct: 307 D-GEYRCLAENSLGSA--RHAYYVTVEAAPYWLHKPQSHLYGP-GETARLDCQVQGRPQP 362
Query: 449 VVSWTKVGRGLQGQAQVD----SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVL 504
V+W G ++ A+ +LIL + +C A N + + +YV+
Sbjct: 363 EVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVV 422
Query: 505 GTSPHVVT 512
++T
Sbjct: 423 QLPAKILT 430
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 124 bits (312), Expect = 4e-28
Identities = 174/703 (24%), Positives = 279/703 (39%), Gaps = 72/703 (10%)
Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGL 72
++++GA K V V GESVVL C+ PP PL + W+ L
Sbjct: 130 LMAEGAPKWPKETVKPVEVEEGESVVLPCN--PPPSAEPLRIY-WMNSKIL--------- 177
Query: 73 YSPRIDPDYVGRVRLQKGASLQIEGLRVEDQ-GWYECRVFF-----LDQHIPEDDFANGS 126
I D RV + + +L + D Y C F + Q P D +
Sbjct: 178 ---HIKQDE--RVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKAT 232
Query: 127 WVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV 186
+ F + L + +P+ L C+A G P P + W + + Q
Sbjct: 233 NSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQN 292
Query: 187 QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246
N TL++ +V G Y C A ++ GSA HA + V P + P++ + L
Sbjct: 293 HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARL 352
Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN- 305
C + P +W + I V +++ Q + RI G+L L QP D C N
Sbjct: 353 DCQVQGRP-QPEVTWRINGIPVEELAKDQ-KYRI-QRGALILSNVQPSDTMVTQCEARNR 409
Query: 306 -GLLHPPSASAYLTVL-YPAQVTAMPPETPLPI-GMPGVIRCPVRANPPLLFVSW-TKDG 361
GLL A+AY+ V+ PA++ +T + + G + C P+ V W +DG
Sbjct: 410 HGLL---LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKA-FGAPVPSVQWLDEDG 465
Query: 362 -KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF 420
LQ ++F ++ GT G I L D G Y C N + + + +K
Sbjct: 466 TTVLQDERFFPYANGTLG--IRDLQANDT-GRYFCLAANDQNNV--TIMANLKVKDATQI 520
Query: 421 IERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD----SNSSLILR 474
+ P+ ++ G + C A DP P ++W GR LQ D + L++
Sbjct: 521 TQGPRST-IEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIH 579
Query: 475 PLTKEAHGHWECSASNAVARVATSTNVYVLGTS---PHVVTNVSVVALPKGANVSWEPGF 531
L G++ C AS + V + + V+G+ P +V + + VSW P
Sbjct: 580 SLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAE 639
Query: 532 D-GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKL 590
D ++++ + + P++ W SL G L P+ Y F V A NK
Sbjct: 640 DHNAPIEKYDIEFEDKEMAPEK----WYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKY 695
Query: 591 GSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVP 650
G G S + E + T AAP P ++ + +V P + W+ P++
Sbjct: 696 GPGEPSPV----SETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLR-WMDWNAPQV-- 748
Query: 651 KRLDGYVLEGR-QGSQG-WE---VLDPAVAGTETELLVPGLIK 688
Y ++ R QG++G W+ V DP + + T VP IK
Sbjct: 749 ----QYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIK 787
Score = 86.7 bits (213), Expect = 1e-16
Identities = 136/575 (23%), Positives = 217/575 (37%), Gaps = 57/575 (9%)
Query: 156 LRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGS 214
L C A G+P+P V W G + Q + NGTL IR ++ +G Y C A++ + +
Sbjct: 446 LLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNN 505
Query: 215 ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA-NLTYSWFQDNINVFHISR 273
T L V I P+++ V+ C A P+ + +W D ++ +
Sbjct: 506 VTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGD 565
Query: 274 LQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETP 333
+ DG L + + D G Y+CV S L S + L V P V +
Sbjct: 566 SDKY--FIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDL 623
Query: 334 --LPIGMPGVIRCPVRA-NPPLLFVSWTKDGKALQLDKFP--GWSQGTEGSLIIALGNED 388
L V P N P+ + K + +K+ G G + S + L +
Sbjct: 624 HLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKL-SPY 682
Query: 389 ALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE---LLIPCSA--- 442
+ T N G PSPV+ ++ A + P + + G E ++I
Sbjct: 683 VHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVD--VKGEGNETTNMVITWKPLRW 740
Query: 443 -QGDPPPV---VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATS 498
+ P V V W G Q Q+ S+ L++ + + A N+ +
Sbjct: 741 MDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEP 800
Query: 499 --TNVYVLGTSPHVVTNVSVVALPKGANV--SWEP---GFDGGYLQRFSV--WYTPLAKR 549
T Y P + + + + + V W P G+L+ ++V W ++
Sbjct: 801 QVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRK 860
Query: 550 PDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTT 609
+ H + VP +++ GL+P++ Y V A N GSGP SE S PEG+P
Sbjct: 861 HSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGH 920
Query: 610 PAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVL------EGRQG 663
P A L ++ +LL W PP L GYVL EG +G
Sbjct: 921 PEALHL----------------ECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKG 964
Query: 664 SQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 698
+ + DP + L P L Y F+L A
Sbjct: 965 QLSFNLRDPELRTHNLTDLSPHL----RYRFQLQA 995
Score = 67.0 bits (162), Expect = 1e-10
Identities = 97/428 (22%), Positives = 159/428 (37%), Gaps = 75/428 (17%)
Query: 132 VNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRG------KDLGQGQGQVQ 185
V PP E P L V + ++L+C A G P W G ++LG Q
Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQ-S 89
Query: 186 VQNGTLRI----RRVERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNST--- 237
+G+ I + G+Y C AS+ G+A +H +L+ G P PK +
Sbjct: 90 PHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW---PKETVKPV 146
Query: 238 -VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLR----LLATQ 292
V + V L C+ L W N + HI + RV + +G+L L +
Sbjct: 147 EVEEGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQ-DERVTMGQNGNLYFANVLTSDN 203
Query: 293 PDDAGCYTCVPSN------------------------GLLHPPSASAYLTVLYPAQVTAM 328
D C+ P LL P ++S++L L
Sbjct: 204 HSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQ------- 256
Query: 329 PPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNED 388
G P V+ C + P + W + + D+ + + ++ +G ED
Sbjct: 257 --------GQPLVLEC-IAEGFPTPTIKWLRPSGPMPADRVT-YQNHNKTLQLLKVGEED 306
Query: 389 ALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPP 448
GEY C NSLG+A V ++A P ++ +P+ + G + C QG P P
Sbjct: 307 D-GEYRCLAENSLGSA--RHAYYVTVEAAPYWLHKPQSHLYGP-GETARLDCQVQGRPQP 362
Query: 449 VVSWTKVGRGLQGQAQVD----SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVL 504
V+W G ++ A+ +LIL + +C A N + + +YV+
Sbjct: 363 EVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVV 422
Query: 505 GTSPHVVT 512
++T
Sbjct: 423 QLPAKILT 430
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 124 bits (311), Expect = 5e-28
Identities = 166/667 (24%), Positives = 248/667 (37%), Gaps = 92/667 (13%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I
Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191
Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G Y C ++ G + +L VL P V P N V C A P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
T W +D+ + + R I D +L++ D G YTCV N ++ ASA
Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304
Query: 316 YLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPG--- 371
LTV P P + + +G +C NP P +F W ++G L +
Sbjct: 305 TLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQPPQS 362
Query: 372 ---WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIERPK 425
+S G L I +G Y C N G T VT V+ PP I +
Sbjct: 363 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 422
Query: 426 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ----AQVDSNSSLILRPLTKEAH 481
V ++ C A G P P + W K G + Q Q++ N L +R
Sbjct: 423 VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE-NGVLQIRYAKLGDT 481
Query: 482 GHWECSASNAVARVATSTNVYVLG----------TSPHVVTNVSVVALPKGANVS----- 526
G + C AS S + V T P+++ S + P+ +VS
Sbjct: 482 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNTVT 539
Query: 527 --WEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHTQY 580
W+P + G TP + + H W ++A V + GL+P+ Y
Sbjct: 540 LSWQPNLNSGA--------TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIY 591
Query: 581 QFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP--- 636
F V A N G S+I S P + P + G+ ++ L ++ + P
Sbjct: 592 LFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPTVL 647
Query: 637 --RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVPGL 686
+ +HW + + + GY + R G W EV PA + +++P L
Sbjct: 648 SSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIPDL 702
Query: 687 IKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFL 746
K V YE + F F S T LE PS PQ V G
Sbjct: 703 RKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG---N 751
Query: 747 GVAVLVS 753
G A+LVS
Sbjct: 752 GTAILVS 758
Score = 116 bits (291), Expect = 1e-25
Identities = 198/849 (23%), Positives = 298/849 (35%), Gaps = 156/849 (18%)
Query: 19 DGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRID 78
D R P V V GE V+ C PP G P I W + G SP D
Sbjct: 132 DFRQNPSDVMVA--VGEPAVMECQ--PPRGHPE-PTISWKKDG------------SPLDD 174
Query: 79 PDYVGRVRLQKGASLQIEGLRVEDQGWYEC----RVFFLDQHIPEDDFANGSWVHLTVNS 134
D +R G L I R D G Y C V + + E LTV
Sbjct: 175 KDERITIR---GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE----------LTVLE 221
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIR 194
P F + P + L V + +C ARG P+P V W+ +L + + +++ + TL+IR
Sbjct: 222 RPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR-DDHTLKIR 279
Query: 195 RVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYP 254
+V G G YTC A + G A + L V PP VV P++ V + V+ C A P
Sbjct: 280 KVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNP 339
Query: 255 ANLTYSWFQDNINVFHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHP 310
+ W ++ S P R + G L + Q D G Y C N
Sbjct: 340 QPAIF-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN----- 393
Query: 311 PSASAYLTVLYPAQVTAMPPETPLPIGMPG------------VIRCPVRANPPLLFVSWT 358
A + +T Y +VT + + P P+ G V+ C V P+ + W
Sbjct: 394 -VAGSIITKAY-LEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWR 450
Query: 359 KDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPP 418
KDG L + Q G L I G Y+C G A S V P
Sbjct: 451 KDG-VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVP 509
Query: 419 AFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSN---SSLILRP 475
RP + LIP + P V ++ L Q ++S +S I+
Sbjct: 510 VQPPRPTDPN--------LIPSAP--SKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEA 559
Query: 476 LTKEAHGHWECSASNAVARVAT---------------STNVY----------------VL 504
+ + W+ A N + + N Y VL
Sbjct: 560 FSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVL 619
Query: 505 GTSPHV---------------VTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKR 549
TS V + N +V++ V W Y+Q + + Y R
Sbjct: 620 PTSQGVDHKQVQRELGNAVLHLHNPTVLS-SSSIEVHWTVDQQSQYIQGYKILY-----R 673
Query: 550 PDRMHH---DWVSLAVPVGAAH-LLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEG 605
P +H DW+ V A + +++P L+ Y+ G SEI +
Sbjct: 674 PSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFA---- 729
Query: 606 LPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQ 665
T AP PP + + G +L+ W PP +G V E +
Sbjct: 730 -KTLEEAPSAPPQGVTVSKNDGNG-------TAILVSWQPPP--EDTQNGMVQEYKVWCL 779
Query: 666 GWEV---LDPAVAGTETELLVPGLIKDVLYEFRLVAF--AGSFVSDPSNTANVSTSGLEV 720
G E ++ V G+ +++P L+ + Y + A AGS V + G V
Sbjct: 780 GNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPV 839
Query: 721 YPS-----RTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQ 775
P Q+ ++ QP +G C++ + ++ SI +R +R+
Sbjct: 840 SPEDQVSLAQQISDVVKQPAFIAGIGAACWI-ILMVFSIWLYRHRKKRNGLTSTYAGIRK 898
Query: 776 DPPLIFSPT 784
P F+PT
Sbjct: 899 VPSFTFTPT 907
Score = 103 bits (256), Expect = 1e-21
Identities = 138/609 (22%), Positives = 231/609 (37%), Gaps = 56/609 (9%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G
Sbjct: 28 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
+L R+ G GVY C A + G A +A+ + + P + V +
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
+ C T SW +D + R+ I G L + T+ DAG Y CV
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDG---SPLDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202
Query: 303 PSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGK 362
+N + S A LTVL P + + +C R + P+ V W KD
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPTVRWRKDDG 261
Query: 363 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIE 422
L ++ T + G+ +G Y+C N +G A S V + PP F+
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTV--QEPPHFVV 316
Query: 423 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSLI 472
+P+++ +GR + C A G+P P + W + G + V L
Sbjct: 317 KPRDQVV-ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 375
Query: 473 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFD 532
+ + + G++ C N + T + V V+ + + +G V+ D
Sbjct: 376 ITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAVD 430
Query: 533 GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSVL 585
G ++ +P+ R D V ++ L G+ +Y +++ +
Sbjct: 431 GTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTCI 487
Query: 586 AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP 645
A G +S + G+P P P P IP S P V + V L W P
Sbjct: 488 ASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQP 544
Query: 646 PELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSF 703
Y++E + G W+ + V TET + GL + +Y F + A
Sbjct: 545 NLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAYG 602
Query: 704 VSDPSNTAN 712
+SDPS ++
Sbjct: 603 ISDPSQISD 611
Score = 41.2 bits (95), Expect = 0.006
Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%)
Query: 784 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 842
TG S S GS + S K +P + + W D P HP P S+ +
Sbjct: 1107 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1166
Query: 843 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 889
E C P R + E E TP R A S + S
Sbjct: 1167 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1221
Query: 890 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 930
SP QP+ C E+ PV+PPP PP P+ P Y+S P
Sbjct: 1222 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1278
Query: 931 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 988
+M D D P EE M TRR LR E P S L +V G+
Sbjct: 1279 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1330
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 124 bits (311), Expect = 5e-28
Identities = 166/667 (24%), Positives = 248/667 (37%), Gaps = 92/667 (13%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I
Sbjct: 172 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 230
Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G Y C ++ G + +L VL P V P N V C A P
Sbjct: 231 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 290
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
T W +D+ + + R I D +L++ D G YTCV N ++ ASA
Sbjct: 291 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 343
Query: 316 YLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPG--- 371
LTV P P + + +G +C NP P +F W ++G L +
Sbjct: 344 TLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQPPQS 401
Query: 372 ---WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIERPK 425
+S G L I +G Y C N G T VT V+ PP I +
Sbjct: 402 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 461
Query: 426 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ----AQVDSNSSLILRPLTKEAH 481
V ++ C A G P P + W K G + Q Q++ N L +R
Sbjct: 462 VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE-NGVLQIRYAKLGDT 520
Query: 482 GHWECSASNAVARVATSTNVYVLG----------TSPHVVTNVSVVALPKGANVS----- 526
G + C AS S + V T P+++ S + P+ +VS
Sbjct: 521 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNTVT 578
Query: 527 --WEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHTQY 580
W+P + G TP + + H W ++A V + GL+P+ Y
Sbjct: 579 LSWQPNLNSGA--------TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIY 630
Query: 581 QFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP--- 636
F V A N G S+I S P + P + G+ ++ L ++ + P
Sbjct: 631 LFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPTVL 686
Query: 637 --RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVPGL 686
+ +HW + + + GY + R G W EV PA + +++P L
Sbjct: 687 SSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIPDL 741
Query: 687 IKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFL 746
K V YE + F F S T LE PS PQ V G
Sbjct: 742 RKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG---N 790
Query: 747 GVAVLVS 753
G A+LVS
Sbjct: 791 GTAILVS 797
Score = 116 bits (291), Expect = 1e-25
Identities = 198/849 (23%), Positives = 298/849 (35%), Gaps = 156/849 (18%)
Query: 19 DGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRID 78
D R P V V GE V+ C PP G P I W + G SP D
Sbjct: 171 DFRQNPSDVMVA--VGEPAVMECQ--PPRGHPE-PTISWKKDG------------SPLDD 213
Query: 79 PDYVGRVRLQKGASLQIEGLRVEDQGWYEC----RVFFLDQHIPEDDFANGSWVHLTVNS 134
D +R G L I R D G Y C V + + E LTV
Sbjct: 214 KDERITIR---GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE----------LTVLE 260
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIR 194
P F + P + L V + +C ARG P+P V W+ +L + + +++ + TL+IR
Sbjct: 261 RPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR-DDHTLKIR 318
Query: 195 RVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYP 254
+V G G YTC A + G A + L V PP VV P++ V + V+ C A P
Sbjct: 319 KVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNP 378
Query: 255 ANLTYSWFQDNINVFHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHP 310
+ W ++ S P R + G L + Q D G Y C N
Sbjct: 379 QPAIF-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN----- 432
Query: 311 PSASAYLTVLYPAQVTAMPPETPLPIGMPG------------VIRCPVRANPPLLFVSWT 358
A + +T Y +VT + + P P+ G V+ C V P+ + W
Sbjct: 433 -VAGSIITKAY-LEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWR 489
Query: 359 KDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPP 418
KDG L + Q G L I G Y+C G A S V P
Sbjct: 490 KDG-VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVP 548
Query: 419 AFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSN---SSLILRP 475
RP + LIP + P V ++ L Q ++S +S I+
Sbjct: 549 VQPPRPTDPN--------LIPSAP--SKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEA 598
Query: 476 LTKEAHGHWECSASNAVARVAT---------------STNVY----------------VL 504
+ + W+ A N + + N Y VL
Sbjct: 599 FSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVL 658
Query: 505 GTSPHV---------------VTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKR 549
TS V + N +V++ V W Y+Q + + Y R
Sbjct: 659 PTSQGVDHKQVQRELGNAVLHLHNPTVLS-SSSIEVHWTVDQQSQYIQGYKILY-----R 712
Query: 550 PDRMHH---DWVSLAVPVGAAH-LLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEG 605
P +H DW+ V A + +++P L+ Y+ G SEI +
Sbjct: 713 PSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFA---- 768
Query: 606 LPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQ 665
T AP PP + + G +L+ W PP +G V E +
Sbjct: 769 -KTLEEAPSAPPQGVTVSKNDGNG-------TAILVSWQPPP--EDTQNGMVQEYKVWCL 818
Query: 666 GWEV---LDPAVAGTETELLVPGLIKDVLYEFRLVAF--AGSFVSDPSNTANVSTSGLEV 720
G E ++ V G+ +++P L+ + Y + A AGS V + G V
Sbjct: 819 GNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPV 878
Query: 721 YPS-----RTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQ 775
P Q+ ++ QP +G C++ + ++ SI +R +R+
Sbjct: 879 SPEDQVSLAQQISDVVKQPAFIAGIGAACWI-ILMVFSIWLYRHRKKRNGLTSTYAGIRK 937
Query: 776 DPPLIFSPT 784
P F+PT
Sbjct: 938 VPSFTFTPT 946
Score = 103 bits (256), Expect = 1e-21
Identities = 138/609 (22%), Positives = 231/609 (37%), Gaps = 56/609 (9%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G
Sbjct: 67 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 125
Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
+L R+ G GVY C A + G A +A+ + + P + V +
Sbjct: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 185
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
+ C T SW +D + R+ I G L + T+ DAG Y CV
Sbjct: 186 PAVMECQPPRGHPEPTISWKKDG---SPLDDKDERITIR-GGKLMITYTRKSDAGKYVCV 241
Query: 303 PSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGK 362
+N + S A LTVL P + + +C R + P+ V W KD
Sbjct: 242 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPTVRWRKDDG 300
Query: 363 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIE 422
L ++ T + G+ +G Y+C N +G A S V + PP F+
Sbjct: 301 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTV--QEPPHFVV 355
Query: 423 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSLI 472
+P+++ +GR + C A G+P P + W + G + V L
Sbjct: 356 KPRDQVV-ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 414
Query: 473 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFD 532
+ + + G++ C N + T + V V+ + + +G V+ D
Sbjct: 415 ITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAVD 469
Query: 533 GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSVL 585
G ++ +P+ R D V ++ L G+ +Y +++ +
Sbjct: 470 GTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTCI 526
Query: 586 AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP 645
A G +S + G+P P P P IP S P V + V L W P
Sbjct: 527 ASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQP 583
Query: 646 PELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSF 703
Y++E + G W+ + V TET + GL + +Y F + A
Sbjct: 584 NLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAYG 641
Query: 704 VSDPSNTAN 712
+SDPS ++
Sbjct: 642 ISDPSQISD 650
Score = 41.2 bits (95), Expect = 0.006
Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%)
Query: 784 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 842
TG S S GS + S K +P + + W D P HP P S+ +
Sbjct: 1146 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1205
Query: 843 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 889
E C P R + E E TP R A S + S
Sbjct: 1206 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1260
Query: 890 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 930
SP QP+ C E+ PV+PPP PP P+ P Y+S P
Sbjct: 1261 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1317
Query: 931 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 988
+M D D P EE M TRR LR E P S L +V G+
Sbjct: 1318 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1369
>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4
[Homo sapiens]
Length = 1250
Score = 124 bits (310), Expect = 7e-28
Identities = 146/583 (25%), Positives = 232/583 (39%), Gaps = 65/583 (11%)
Query: 160 ARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRR--VERGSS-----------GVYTC 206
A P VTW G L + + NG+L + + GS G Y+C
Sbjct: 62 AAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYSC 121
Query: 207 QASSTEGSATHATQLLVLGPPV-IVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDN 265
A G T ++ L + P++ TV + CH E PA + +W +D
Sbjct: 122 LAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPII-TWEKDQ 180
Query: 266 INVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQ- 324
+ + +PR+ +L +G L++L Q DAG Y CV +N S A L+V +
Sbjct: 181 VTLPE----EPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHRGSL 236
Query: 325 ---------VTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTK-DGKALQLDKFPGWSQ 374
+ A P T + G V+ C A+P FVSW + DGK + D
Sbjct: 237 ASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTP-FVSWVRQDGKPISTDVIVLGRT 295
Query: 375 GTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGR 434
+L+IA G Y C + + + A PA + P E +
Sbjct: 296 ----NLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAP-EALSRTRAS 350
Query: 435 ELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNA 491
C A G+P P + W G L+ +V SL++ + + G+++C A N+
Sbjct: 351 TARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENS 410
Query: 492 --VARVATSTNVYVLGTSPHVVTNVSVVALPKGAN-VSWE-PGFDGGYLQRFSVWYTPLA 547
+A A S V V P T V+ L A V+WE P + FS+ Y A
Sbjct: 411 AGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQK-A 469
Query: 548 KRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLP 607
+ D + + + AV L V L+P+T Y+F V+A ++LG+ S
Sbjct: 470 RGMDNVEYQF---AVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTS----------- 515
Query: 608 TTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP--PELVPKRLDGYVLEGRQGSQ 665
P L T P + P+ ++ P + + W P P L ++ Y +E G +
Sbjct: 516 ----TPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKE 571
Query: 666 GWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPS 708
++ V G ET+L++ L + +Y R+ A + PS
Sbjct: 572 D-QIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPS 613
Score = 83.6 bits (205), Expect = 1e-15
Identities = 144/611 (23%), Positives = 227/611 (37%), Gaps = 93/611 (15%)
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202
P V+E C G P P +TW+ L + + + NG L+I V+ +G
Sbjct: 149 PESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAG 208
Query: 203 VYTCQASSTEGSATHATQLLVLG-------------PPVIVVPPKNSTVNASQDVSLACH 249
Y C A T + H +Q +L VIV P+N+TV + Q V + C
Sbjct: 209 PYRCVA--TNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECV 266
Query: 250 AEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLH 309
A A P SW + + + V +L +L + QP +G Y C +
Sbjct: 267 ASADPTPFV-SWVRQD-----GKPISTDVIVLGRTNLLIANAQPWHSGVYVC-----RAN 315
Query: 310 PPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVR-----ANPPLLFVSWTKDGKAL 364
P + T +V A P T P + R + P + W +G L
Sbjct: 316 KPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPL 375
Query: 365 QLDKFPGWSQGTEGSLIIA-LGNEDALGEYSCTPYNSLGTA----------------GPS 407
+ + QG GSL+I +G +DA G Y C NS G A P+
Sbjct: 376 RPNGRVK-VQGGGGSLVITQIGLQDA-GYYQCVAENSAGMACAAASLAVVVREGLPSAPT 433
Query: 408 PVTRVLLKAPPAFI--ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV 465
VT L + + ERP+ Q +G L + D ++ Q V
Sbjct: 434 RVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMD------------NVEYQFAV 481
Query: 466 DSNSS-LILRPLTKEAHGHWECSASN--AVARVATSTNVYVLGTSPHVVTNVSVVA-LPK 521
+++++ L +R L + A + +R +T V+ L P +S+ + P
Sbjct: 482 NNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPS 541
Query: 522 GANVSW---EPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHT 578
V+W P G + ++ + Y + D++ S V L++ LQP+
Sbjct: 542 DIRVAWLPLPPSLSNGQVVKYKIEYG--LGKEDQI----FSTEVRGNETQLMLNSLQPNK 595
Query: 579 QYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP-- 636
Y+ + A G G S+ + + P P E+ +V+ + P
Sbjct: 596 VYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVP-FAPAELKVQAKMESLVVSWQPPPH 654
Query: 637 ----RGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEV----LDPAVAGTETELLVPGLIK 688
G L+W + +G L G +G Q W+V L V E LVPG
Sbjct: 655 PTQISGYKLYWREVG-AEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGR-- 711
Query: 689 DVLYEFRLVAF 699
LYE +LVAF
Sbjct: 712 --LYEVKLVAF 720
Score = 61.6 bits (148), Expect = 4e-09
Identities = 101/401 (25%), Positives = 144/401 (35%), Gaps = 85/401 (21%)
Query: 569 LLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPR 628
+L+ GL+P T+Y+F+V + GPF +V + T P P PP+++ LSP
Sbjct: 808 ILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERS-----TLPDRPSTPPSDL--RLSP-- 858
Query: 629 GLVAVRTPRGVLLHWDPP-----ELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTETELLV 683
TP V LHW PP E+V + L Y Q W +L G V
Sbjct: 859 -----LTPSTVRLHWCPPTEPNGEIV-EYLILYSSNHTQPEHQWTLL--TTQGNIFSAEV 910
Query: 684 PGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGV 743
GL D Y F++ A S +V T + +L L + G++ GV
Sbjct: 911 HGLESDTRYFFKMGARTEVGPGPFSRLQDVIT-------LQEKLSDSLDMHSVTGIIVGV 963
Query: 744 CFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPT-GKSAAPSALGSGSPDSVA 802
C LG+ CLL A RR P L + T G A S G P A
Sbjct: 964 C-LGLL--------CLLACMCAGLRRSPHRESLPGLSSTATPGNPALYSRARLGPPSPPA 1014
Query: 803 KLKLQG---------SPVPS----------------------LRQSLLWGDPAG------ 825
+L+ SP PS ++ + W P+G
Sbjct: 1015 AHELESLVHPHPQDWSPPPSDVEDRAEVHSLMGGGVSEGRSHSKRKISWAQPSGLSWAGS 1074
Query: 826 -----TPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRL 880
P P P +R LP G ++ V + +GR+++ P Q
Sbjct: 1075 WAGCELPQAGPRPALTRALLP----PAGTGQTLLLQALVYDAIKGNGRKKSPPACRNQVE 1130
Query: 881 ARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSPLPGPG 921
A S S S L ++D+ P P P P + G G
Sbjct: 1131 AEVIVHSDFSASNGNPDLHLQDLEPEDPLPPEAPDLISGVG 1171
Score = 52.8 bits (125), Expect = 2e-06
Identities = 121/547 (22%), Positives = 201/547 (36%), Gaps = 82/547 (14%)
Query: 224 LGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVD 283
+GP +++ P+ + V + SL A P +T W +D + L +L +
Sbjct: 40 VGPLQVILGPEQAAV---LNCSLGAAAAGPPTRVT--WSKDGDTLLEHDHLH----LLPN 90
Query: 284 GSLRL---LATQPDDA----------GCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPP 330
GSL L LA D G Y+C+ L S +A + + A + P
Sbjct: 91 GSLWLSQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPE 150
Query: 331 ETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDAL 390
+ C + P + ++W KD + L + P G L I E
Sbjct: 151 SQTVEENGTARFECHIEGLPAPI-ITWEKD--QVTLPEEPRLIVLPNGVLQILDVQESDA 207
Query: 391 GEYSCTPYNSL---------------GTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 435
G Y C NS G+ + V++ A P E G+
Sbjct: 208 GPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAP-------ENTTVVSGQS 260
Query: 436 LLIPCSAQGDPPPVVSWTKV-GRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVAR 494
+++ C A DP P VSW + G+ + V ++L++ G + C A+ R
Sbjct: 261 VVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTR 320
Query: 495 -VATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRM 553
AT+ + +P + ++ + + + G + RP+
Sbjct: 321 DFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGR 380
Query: 554 HHDWVSLAVPVGAAHLLVP--GLQPHTQYQFSVLAQNKLGSG-PFSEIVLSAPEGLPTTP 610
+ V G L++ GLQ YQ +A+N G + + + EGLP+ P
Sbjct: 381 ------VKVQGGGGSLVITQIGLQDAGYYQ--CVAENSAGMACAAASLAVVVREGLPSAP 432
Query: 611 AAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVL 670
P + VL+ W+ PE+ +++ G+ L Q ++G + +
Sbjct: 433 TRVTATPL----------------SSSAVLVAWERPEMHSEQIIGFSLH-YQKARGMDNV 475
Query: 671 DP--AVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRT-QL 727
+ AV TEL V L + YEF +VA++ S S A V T L+ PS QL
Sbjct: 476 EYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHT--LDDVPSAAPQL 533
Query: 728 PGLLPQP 734
P P
Sbjct: 534 SLSSPNP 540
Score = 35.0 bits (79), Expect = 0.42
Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 4/80 (5%)
Query: 520 PKGANVSWEPGFD-GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHT 578
P + W P + G + + + Y+ +P+ H W L V GL+ T
Sbjct: 861 PSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPE---HQWTLLTTQGNIFSAEVHGLESDT 917
Query: 579 QYQFSVLAQNKLGSGPFSEI 598
+Y F + A+ ++G GPFS +
Sbjct: 918 RYFFKMGARTEVGPGPFSRL 937
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 124 bits (310), Expect = 7e-28
Identities = 182/715 (25%), Positives = 270/715 (37%), Gaps = 102/715 (14%)
Query: 25 EVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGR 84
E V + G SV+L C A P IEW + G L + + D R
Sbjct: 58 EPVDTLSVRGSSVILNCS----AYSEPSPKIEWKKDGTFLNL----------VSDD---R 100
Query: 85 VRLQKGASLQIEGL-----RVEDQGWYEC--RVFFLDQHIPEDDFANGSWVHLTVNSPPQ 137
+L SL I + D+G+Y+C V L I L V P+
Sbjct: 101 RQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRT-------AKLIVAGLPR 153
Query: 138 FQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVE 197
F P V L C +P V W+ + L +++ +G L I
Sbjct: 154 FTSQPEPS-SVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNAT 212
Query: 198 RGSSGVYTCQASST-EGSATHATQLLVLGPP------VIVVPPKNSTVNASQDVSLACHA 250
G G+Y C S + +L VL P V + P QDV L C A
Sbjct: 213 EGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVA 272
Query: 251 EAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHP 310
P T W ++ + S R+ +L GSL + DDAG Y C+ NG
Sbjct: 273 SGLPTP-TIKWMKNEEALDTES--SERLVLLAGGSLEISDVTEDDAGTYFCIADNGN-ET 328
Query: 311 PSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGK-ALQLDKF 369
A A LTV + P M V C V P V W K+G + D F
Sbjct: 329 IEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPT-VKWVKNGDMVIPSDYF 387
Query: 370 PGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA---FIERPKE 426
+ L + +E G Y C N +G A +L AP P++
Sbjct: 388 KIVKEHNLQVLGLVKSDE---GFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRD 444
Query: 427 EYFQEVGRELL-----IPCS-AQGDPPPV-VSWTKVGRGLQ--------GQAQVDSNSSL 471
V + P S GD V +TK G + G+ QV + +
Sbjct: 445 VVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLM 504
Query: 472 -----ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVS 526
I R + + HG E S+A RV T V + G +P++ + A P V+
Sbjct: 505 PATVYIFRVMAQNKHGSGE---SSAPLRVETQPEVQLPGPAPNLR---AYAASPTSITVT 558
Query: 527 WEPGFDG-GYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVL 585
WE G G +Q + ++Y + K D+ V V + + GL+ +T+Y F V+
Sbjct: 559 WETPVSGNGEIQNYKLYY--MEKGTDKEQD------VDVSSHSYTINGLKKYTEYSFRVV 610
Query: 586 AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP 645
A NK G G +S P+ T + P+ P LS + VR + +++HW P
Sbjct: 611 AYNKHGPG------VSTPDVAVRTLSDV---PSAAPQNLS-----LEVRNSKSIMIHWQP 656
Query: 646 PELVPK--RLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 698
P + ++ GY + R+ S+ +V + V+GT+ L+ GL + Y FR+ A
Sbjct: 657 PAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAA 711
Score = 112 bits (281), Expect = 2e-24
Identities = 153/607 (25%), Positives = 228/607 (37%), Gaps = 68/607 (11%)
Query: 134 SPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGK--DLGQGQGQVQVQNGTL 191
+P F P L V+ V L C A P P + WK G +L + + +G+L
Sbjct: 51 TPFYFLVEPVDTLSVRG-SSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSL 109
Query: 192 RIRRV-----ERGSSGVYTCQAS--STEGSATHATQLLVLGPPVIVVPPKNSTVNASQDV 244
I V + G Y C A+ S + +L+V G P P+ S+V A +
Sbjct: 110 FISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNA 169
Query: 245 SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPS 304
L C A W Q+ + L RV L G L + D G Y CV
Sbjct: 170 ILNCEVNADLVPFV-RWEQNRQPLL----LDDRVIKLPSGMLVISNATEGDGGLYRCVVE 224
Query: 305 NGLLHPPSASAYLTVLYPAQVTA------MPPETPLPIGMPGVIRCPVRANPPLLFVSWT 358
+G S L VL +V + P IG V+ C V + P + W
Sbjct: 225 SGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPC-VASGLPTPTIKWM 283
Query: 359 KDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPP 418
K+ +AL + GSL I+ ED G Y C N G + ++A P
Sbjct: 284 KNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADN--GNETIEAQAELTVQAQP 341
Query: 419 AFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPL 476
F+++P Y E +++ C G P P V W K G + ++ +L + L
Sbjct: 342 EFLKQPTNIYAHE-SMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGL 400
Query: 477 TKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTN--------VSVVALPKGANVSWE 528
K G ++C A N V + +L +P V+ + + ++W
Sbjct: 401 VKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWR 460
Query: 529 -PGFDG-GYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLA 586
P D G +SV+YT +R+ + G + + L P T Y F V+A
Sbjct: 461 TPASDPHGDNLTYSVFYTKEGIARERVEN-----TSHPGEMQVTIQNLMPATVYIFRVMA 515
Query: 587 QNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPP 646
QNK GSG SAP + T P ++P P R A +P + + W+ P
Sbjct: 516 QNKHGSGE-----SSAPLRVETQ------PEVQLPGPAPNLRAYAA--SPTSITVTWETP 562
Query: 647 ELVPKRLDGYVL----EGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAF--A 700
+ Y L +G Q +V + + GL K Y FR+VA+
Sbjct: 563 VSGNGEIQNYKLYYMEKGTDKEQDVDV-------SSHSYTINGLKKYTEYSFRVVAYNKH 615
Query: 701 GSFVSDP 707
G VS P
Sbjct: 616 GPGVSTP 622
Score = 66.2 bits (160), Expect = 2e-10
Identities = 127/563 (22%), Positives = 223/563 (39%), Gaps = 89/563 (15%)
Query: 208 ASSTEGSATHA--TQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDN 265
A++ GSA + + P +V P ++ V L C A + P+ W +D
Sbjct: 32 AAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSP-KIEWKKDG 90
Query: 266 INVFHISRLQPRVRILVDGSLRLLAT------QPDDAGCYTCVPS-NGLLHPPSASAYLT 318
+ +S R ++L DGSL + +PD+ G Y CV + L S +A L
Sbjct: 91 TFLNLVS--DDRRQLLPDGSLFISNVVHSKHNKPDE-GYYQCVATVESLGTIISRTAKLI 147
Query: 319 VLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLD----KFPGWSQ 374
V + T+ P + + G ++ C V A+ + FV W ++ + L LD K P
Sbjct: 148 VAGLPRFTSQPEPSSVYAGNNAILNCEVNADL-VPFVRWEQNRQPLLLDDRVIKLPS--- 203
Query: 375 GTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVT-RVLLKAPP--------AFIERPK 425
G L+I+ E G Y C + + GP + V LK P F+++P
Sbjct: 204 ---GMLVISNATEGDGGLYRCV----VESGGPPKYSDEVELKVLPDPEVISDLVFLKQPS 256
Query: 426 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQ----VDSNSSLILRPLTKEAH 481
+ +G+++++PC A G P P + W K L ++ + + SL + +T++
Sbjct: 257 P-LVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDA 315
Query: 482 GHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSV 541
G + C A N + + V P + + + + ++ +E G
Sbjct: 316 GTYFCIADNGNETIEAQAELTV-QAQPEFLKQPTNIYAHESMDIVFECEVTGK------- 367
Query: 542 WYTPLAKRPDRMHHDWV---SLAVP------VGAAHLLVPGLQPHTQYQFSVLAQNKLGS 592
TP K WV + +P V +L V GL + + +A+N +G+
Sbjct: 368 -PTPTVK--------WVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGN 418
Query: 593 GPF-SEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVP- 650
+++++ L PA G P P +P + ++ + R + L W P P
Sbjct: 419 AQAGAQLII-----LEHAPATTG------PLPSAPRDVVASLVSTRFIKLTWRTPASDPH 467
Query: 651 -KRLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSN 709
L V ++G V + + G E ++ + L+ +Y FR++A + S
Sbjct: 468 GDNLTYSVFYTKEGIARERVENTSHPG-EMQVTIQNLMPATVYIFRVMAQNKHGSGESSA 526
Query: 710 TANVSTSGLEVYPSRTQLPGLLP 732
V T QLPG P
Sbjct: 527 PLRVETQ------PEVQLPGPAP 543
Score = 52.4 bits (124), Expect = 3e-06
Identities = 50/211 (23%), Positives = 83/211 (39%), Gaps = 35/211 (16%)
Query: 24 PEVVS----------VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLY 73
PEV+S +V G+ VVL C A P I+W++
Sbjct: 243 PEVISDLVFLKQPSPLVRVIGQDVVLPC----VASGLPTPTIKWMK-------------N 285
Query: 74 SPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVN 133
+D + R+ L G SL+I + +D G Y C ++ I + LTV
Sbjct: 286 EEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIE-------AQAELTVQ 338
Query: 134 SPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRI 193
+ P+F + P + + ++ + C G P P V W G + V+ L++
Sbjct: 339 AQPEFLKQPTNIYAHESMD-IVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQV 397
Query: 194 RRVERGSSGVYTCQASSTEGSATHATQLLVL 224
+ + G Y C A + G+A QL++L
Sbjct: 398 LGLVKSDEGFYQCIAENDVGNAQAGAQLIIL 428
Score = 40.0 bits (92), Expect = 0.013
Identities = 34/113 (30%), Positives = 49/113 (43%), Gaps = 5/113 (4%)
Query: 489 SNAVARVATSTNVYVLGTSPHV-VTNVSVVALPKGANVSWEPGFDG-GYLQRFSVWYTPL 546
S+ + A T ++ TSP VT VS PK V+W+P + G + + ++Y+
Sbjct: 938 SSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTD 997
Query: 547 AKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV 599
HDWV V + L T Y F + A+N G GP SE V
Sbjct: 998 VNAEI---HDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAV 1047
Score = 39.3 bits (90), Expect = 0.022
Identities = 34/136 (25%), Positives = 56/136 (41%), Gaps = 24/136 (17%)
Query: 570 LVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRG 629
LV GL+P+T Y+FSV+ S +S L P SPP+
Sbjct: 916 LVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFEL---------------VPTSPPKD 960
Query: 630 LVAVR---TPRGVLLHWDPPELVPKRLDGYVL----EGRQGSQGWEVLDPAVAGTETELL 682
+ V P+ ++++W PP ++ GY++ + W V++P V G
Sbjct: 961 VTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDW-VIEP-VVGNRLTHQ 1018
Query: 683 VPGLIKDVLYEFRLVA 698
+ L D Y F++ A
Sbjct: 1019 IQELTLDTPYYFKIQA 1034
>gi|83281200 protogenin [Homo sapiens]
Length = 1150
Score = 123 bits (309), Expect = 9e-28
Identities = 140/582 (24%), Positives = 238/582 (40%), Gaps = 59/582 (10%)
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRI-----RRVE 197
P + V +PV L C A G VTW G + + + + NG+L I RR E
Sbjct: 45 PQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGE 104
Query: 198 RGSSGVYTCQASSTEGSATHATQLLVLGP-PVIVVPPKNSTVNASQDVSLACHAEAYPAN 256
+ G Y C A + G+ L L V P ++ V+ AC ++P
Sbjct: 105 QSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPP- 163
Query: 257 LTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAY 316
+W N + R+ L G L++ D+G Y C+ + S A
Sbjct: 164 AVITW---EFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEAS 220
Query: 317 LTVL--------YPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTK-DGKALQLD 367
LTV+ + + A P + V+ C NP + +SW++ D K+ +D
Sbjct: 221 LTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPI-ISWSRLDHKS--ID 277
Query: 368 KFPGWSQGTEGSLIIALGNEDALGEYSC---TPYNSLGTAGPSPVTRVLLKAPPAFIERP 424
F G G+L+I+ G Y C TP T + +T + APP+F+E P
Sbjct: 278 VFNTRVLG-NGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLT---VLAPPSFVEWP 333
Query: 425 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDS-NSSLILRPLTKEAHGH 483
+ G + C A+G P P +SW K GR + ++ NS L++ + E
Sbjct: 334 ESLTRPRAGTARFV-CQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAI 392
Query: 484 WECSASNAVARVATSTNVYVLGTS--PHVVTNVSVVALPKGA-NVSWE-PGFDGGYLQRF 539
++C A N+ + + + V+ + P NV + A ++WE P ++ + +
Sbjct: 393 YQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAY 452
Query: 540 SVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV 599
SV Y + + ++++ + + H ++ L+P + Y F ++A +G+ S+ V
Sbjct: 453 SVHY----MKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHV 508
Query: 600 LSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKR--LDGYV 657
T PL PP + R+P +L+ W P +R + Y
Sbjct: 509 TQ---------------NTLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYR 553
Query: 658 LEGRQGSQ-GWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 698
L R ++ +VL+ + GT E L+ GL D +Y R+ A
Sbjct: 554 LSFRLSTENSIQVLE--LPGTTHEYLLEGLKPDSVYLVRITA 593
Score = 45.1 bits (105), Expect = 4e-04
Identities = 31/122 (25%), Positives = 47/122 (38%), Gaps = 7/122 (5%)
Query: 573 GLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVA 632
GL P +Y +LA N + G ++ +S TP + +PPP P
Sbjct: 679 GLDPRRKYHVRLLAYNNIDDGYQADQTVS-------TPGCVSVRDRMVPPPPPPHHLYAK 731
Query: 633 VRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLY 692
T + LHW P ++ Y + L + +ET +LV GL + Y
Sbjct: 732 ANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKY 791
Query: 693 EF 694
EF
Sbjct: 792 EF 793
Score = 42.7 bits (99), Expect = 0.002
Identities = 59/263 (22%), Positives = 101/263 (38%), Gaps = 36/263 (13%)
Query: 529 PGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQN 588
P F + +++ P+ + + + L + H+LV GL+P+T+Y+F+V
Sbjct: 745 PAFTAAQIINYTIRCNPVG-----LQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHV 799
Query: 589 KLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPL-SPPRGLVAVRTPRGVLLHWDPPE 647
S P+S +V + T P AP PP + L LV+ + P D PE
Sbjct: 800 DQLSSPWSPVVYHS-----TLPEAPAGPPVGVKVTLIEDDTALVSWKPP-------DGPE 847
Query: 648 LVPKRLDGYVLEGRQGSQG-WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSD 706
V R + G W+VL G T L+ L+ +Y ++ A
Sbjct: 848 TVVTRYTILYASRKAWIAGEWQVLHR--EGAITMALLENLVAGNVYIVKISASNEVGEGP 905
Query: 707 PSNTANVSTSGLEVYPSRTQLPGL-------------LPQPVLAGVVGGVCFLGVAVLVS 753
SN+ ++ E S + L L Q + G+ GV +L+
Sbjct: 906 FSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILIC 965
Query: 754 ILAGCLLNRRRAARRRRKRLRQD 776
+L L+ R +A + + Q+
Sbjct: 966 VL--ILIYRSKARKSSASKTAQN 986
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 122 bits (306), Expect = 2e-27
Identities = 127/473 (26%), Positives = 206/473 (43%), Gaps = 80/473 (16%)
Query: 87 LQKGASLQIEGLRVE----------DQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPP 136
L G +++I G+ E D G Y+C F + D+ V L +P
Sbjct: 354 LNPGKNVRITGINHENLIMDHMVKSDGGAYQC--FVRKDKLSAQDYVQ---VVLEDGTPK 408
Query: 137 QFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQ----GQVQVQNGT-- 190
V V EPV+L C +G+PLP +TW L + +G Q+ G
Sbjct: 409 IISAFSEKV--VSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV 466
Query: 191 --LRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC 248
L I + GVY C A+++ G + ++ V G P + P KN T A +D + C
Sbjct: 467 SYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG-PASIRPMKNITAIAGRDTYIHC 525
Query: 249 HAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPD-DAGCYTCVPSNGL 307
YP + W++ N N+ + Q V +G+L+L Q + D G YTC N L
Sbjct: 526 RVIGYP-YYSIKWYK-NSNLLPFNHRQ--VAFENNGTLKLSDVQKEVDEGEYTC---NVL 578
Query: 308 LHP---PSASAYLTVLYPAQVTAMPPETP-LPIGMPGVIRCPVRANPPLLFVSWTKDGKA 363
+ P S S ++TV P + P E P IG I C V + + ++W KDG+
Sbjct: 579 VQPQLSTSQSVHVTVKVPPFI--QPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRP 636
Query: 364 LQLDKFPGWSQGTEGSLIIALGNEDAL-------------GEYSCTPYNSLGTAGPSPVT 410
+ GSL + + N D G Y+C N A +
Sbjct: 637 I------------PGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNE--AAAVEHQS 682
Query: 411 RVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRG----------LQ 460
+++++ PP F+ +P+++ G+ +++ CSA+G P P + W K +G L
Sbjct: 683 QLIVRVPPKFVVQPRDQ-DGIYGKAVILNCSAEGYPVPTIVW-KFSKGAGVPQFQPIALN 740
Query: 461 GQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTN 513
G+ QV SN SL+++ + +E G++ C SN V S ++Y+ P ++T+
Sbjct: 741 GRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVG-ADVSKSMYLTVKIPAMITS 792
Score = 113 bits (283), Expect = 9e-25
Identities = 159/698 (22%), Positives = 277/698 (39%), Gaps = 109/698 (15%)
Query: 51 PLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVE-DQGWYECR 109
P + I+W + LLP ++ R +V + +L++ ++ E D+G Y C
Sbjct: 531 PYYSIKWYKNSNLLP-------FNHR-------QVAFENNGTLKLSDVQKEVDEGEYTCN 576
Query: 110 VFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLP-HV 168
V Q + VH+TV PP Q P + V + CV LP +
Sbjct: 577 VLVQPQ------LSTSQSVHVTVKVPPFIQ--PFEFPRFSIGQRVFIPCVVVSGDLPITI 628
Query: 169 TWKLRGKDLGQGQGQVQVQN----GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVL 224
TW+ G+ + G V + N +LRI + +G YTC A + + H +QL+V
Sbjct: 629 TWQKDGRPIPGSLG-VTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
Query: 225 GPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV--FHISRLQPRVRILV 282
PP VV P++ + V L C AE YP F V F L R+++L
Sbjct: 688 VPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLS 747
Query: 283 DGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVI 342
+GSL + +D+G Y C SN + S S YLTV PA +T+ P T G +
Sbjct: 748 NGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEM 807
Query: 343 RCPVRANPPLLFVSWTKDGKAL--QLDKFPGWSQGTEGSLIIALG-----NEDALGEYSC 395
C P++ V W K+ + + ++ ++ ++ +I L ED+ G +SC
Sbjct: 808 SCTAHGEKPII-VRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDS-GFFSC 865
Query: 396 TPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELL------------------ 437
NS G + ++ ++ PP P E ++V +
Sbjct: 866 HAINSYGE--DRGIIQLTVQEPP----DPPEIEIKDVKARTITLRWTMGFDGNSPITGYD 919
Query: 438 IPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVAT 497
I C + D SW R Q++S + + + P + + + A N + +
Sbjct: 920 IECKNKSD-----SWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMY---AKNRIGKSEP 971
Query: 498 STNVYVLG-----TSPHVVTNVSVVALPKGANVSW---EPGFDGGYLQRFSVWYTPLAKR 549
S + + P ++ ++ + V+W + G ++ + + Y +
Sbjct: 972 SNELTITADEAAPDGPPQEVHLEPIS-SQSIRVTWKAPKKHLQNGIIRGYQIGYREYS-T 1029
Query: 550 PDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAPEGLPT 608
+ +S+ + + L TQY V A N+ G+GP S EI+ + E +P+
Sbjct: 1030 GGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPS 1089
Query: 609 TPAAPGLPPTEIPPPLSPPRGLVAVRT-PRGVLLHWDPPELVPKRLDGYVLEGRQGSQGW 667
PP + A+ T P + + W L + L+G +L+G +
Sbjct: 1090 ----------------YPPENVQAIATSPESISISWS--TLSKEALNG-ILQGFRVIYWA 1130
Query: 668 EVLD------PAVAGTETELLVPGLIKDVLYEFRLVAF 699
++D + T+ L + GL K Y +++AF
Sbjct: 1131 NLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAF 1168
Score = 70.1 bits (170), Expect = 1e-11
Identities = 106/444 (23%), Positives = 173/444 (38%), Gaps = 48/444 (10%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
R + +L I+ ++ ED G Y R ++ E +N + L V+ P + P
Sbjct: 172 RFLITSTGALYIKDVQNED-GLYNYRCITRHRYTGETRQSNSA--RLFVSDPAN---SAP 225
Query: 144 AVLE------VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVE 197
++L+ + V L C A G P P W L + G+ Q L I +
Sbjct: 226 SILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPL-ELSGRFQKTVTGLLIENIR 284
Query: 198 RGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANL 257
SG Y C+ S+ G+A +L V P + P+ + VSL+C +
Sbjct: 285 PSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTG-TEDQ 343
Query: 258 TYSWFQDNINVFHISRLQPRVRILVDG----SLRLLATQPDDAGCYTCVPSNGLLHPPSA 313
SW+++ L P + + G +L + D G Y C L SA
Sbjct: 344 ELSWYRNG------EILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKL---SA 394
Query: 314 SAYLTVLY----PAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKF 369
Y+ V+ P ++A + P P + C V+ PL ++WT D +
Sbjct: 395 QDYVQVVLEDGTPKIISAFSEKVVSP-AEPVSLMCNVKGT-PLPTITWTLDDDPILKGGS 452
Query: 370 PGWSQ--GTEGSLIIALGNEDAL----GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIER 423
SQ +EG+++ L + G Y CT NS G R+ ++ P + R
Sbjct: 453 HRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVV--LYQARINVRGPASI--R 508
Query: 424 PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEA 480
P + GR+ I C G P + W K L Q ++N +L L + KE
Sbjct: 509 PMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV 568
Query: 481 -HGHWECSASNAVARVATSTNVYV 503
G + C+ +++TS +V+V
Sbjct: 569 DEGEYTCNVL-VQPQLSTSQSVHV 591
Score = 69.7 bits (169), Expect = 2e-11
Identities = 110/505 (21%), Positives = 185/505 (36%), Gaps = 41/505 (8%)
Query: 156 LRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQN-GTLRIRRVERG-SSGVYTCQASSTEG 213
+ C G P + W L QV +N GTL++ V++ G YTC
Sbjct: 523 IHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQ 582
Query: 214 SATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISR 273
+T + + + P + P + + Q V + C + +T +W +D
Sbjct: 583 LSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDG------RP 636
Query: 274 LQPRVRILVDG-----SLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAM 328
+ + + +D SLR+ G YTC+ N S L V P +
Sbjct: 637 IPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQ-LIVRVPPKFVVQ 695
Query: 329 PPETPLPIGMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFP--GWSQG-TEGSLIIAL 384
P + G ++ C P P + ++K Q G Q + GSL+I
Sbjct: 696 PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKH 755
Query: 385 GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQG 444
E+ G Y C N +G A S + +K P P + G++ + C+A G
Sbjct: 756 VVEEDSGYYLCKVSNDVG-ADVSKSMYLTVKIPAMITSYPNTTLATQ-GQKKEMSCTAHG 813
Query: 445 DPPPVVSWTK--------VGRGLQGQAQVDSN--SSLILRPLTKEAHGHWECSASNAVAR 494
+ P +V W K + R L +V S+L + P +E G + C A N+
Sbjct: 814 EKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGE 873
Query: 495 VATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMH 554
+ V + V + + W GFDG + + + D
Sbjct: 874 DRGIIQLTVQEPPDPPEIEIKDVK-ARTITLRWTMGFDGN--SPITGYDIECKNKSDSWD 930
Query: 555 HDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLG-SGPFSEIVLSAPEGLPTTPAAP 613
+ V + + P + Y + A+N++G S P +E+ ++A E AAP
Sbjct: 931 SAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADE------AAP 984
Query: 614 GLPPTEIP-PPLSPPRGLVAVRTPR 637
PP E+ P+S V + P+
Sbjct: 985 DGPPQEVHLEPISSQSIRVTWKAPK 1009
Score = 69.3 bits (168), Expect = 2e-11
Identities = 47/179 (26%), Positives = 79/179 (44%), Gaps = 26/179 (14%)
Query: 434 RELLIPCSAQGDPPPVVSWTKVGRG------LQGQAQVDSNSSLILRPLTKEAHGHWECS 487
+++++PC A GDP P V W K G + G+ + SN S I+R + E G++ C
Sbjct: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360
Query: 488 ASN--AVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDG-----GYLQRFS 540
A+N + + V V P + + + +SW PG +G GY+ ++S
Sbjct: 1361 ANNNWGSDEIILNLQVQVPPDQPRLTVSKTT---SSSITLSWLPGDNGGSSIRGYILQYS 1417
Query: 541 VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV 599
+ W S + + L+ T Y+F++ AQN +G G SEI+
Sbjct: 1418 ----------EDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEII 1466
Score = 45.4 bits (106), Expect = 3e-04
Identities = 53/207 (25%), Positives = 80/207 (38%), Gaps = 31/207 (14%)
Query: 31 GRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYV-GRVRLQK 89
G G++V+L C A P+ I W G P+ P + GR+++
Sbjct: 701 GIYGKAVILNCS----AEGYPVPTIVWK---------FSKGAGVPQFQPIALNGRIQVLS 747
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETPPAVLEV 148
SL I+ + ED G+Y C+V D A+ S ++LTV P P L
Sbjct: 748 NGSLLIKHVVEEDSGYYLCKV-------SNDVGADVSKSMYLTVKIPAMITSYPNTTLAT 800
Query: 149 QELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQN--------GTLRIRRVERGS 200
Q + + C A G V W+ + + + V TL+I R
Sbjct: 801 QG-QKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVRED 859
Query: 201 SGVYTCQASSTEGSATHATQLLVLGPP 227
SG ++C A ++ G QL V PP
Sbjct: 860 SGFFSCHAINSYGEDRGIIQLTVQEPP 886
Score = 36.6 bits (83), Expect = 0.14
Identities = 27/84 (32%), Positives = 36/84 (42%), Gaps = 10/84 (11%)
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-------NGTLRIRRVERGSSGV 203
++ + L C A G P P V W KD V + NG+ IR V+ SG
Sbjct: 1300 MKDIVLPCKAVGDPSPAVKWM---KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGY 1356
Query: 204 YTCQASSTEGSATHATQLLVLGPP 227
Y+C A++ GS L V PP
Sbjct: 1357 YSCIANNNWGSDEIILNLQVQVPP 1380
Score = 32.0 bits (71), Expect = 3.6
Identities = 16/64 (25%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 242 QDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTC 301
+D+ L C A P+ W +D+ + + R I +GS + + +D+G Y+C
Sbjct: 1301 KDIVLPCKAVGDPSPAV-KWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSC 1359
Query: 302 VPSN 305
+ +N
Sbjct: 1360 IANN 1363
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 121 bits (304), Expect = 3e-27
Identities = 143/570 (25%), Positives = 230/570 (40%), Gaps = 51/570 (8%)
Query: 152 EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIR--RVERGSS----GVYT 205
+P+ L C G+P +TW+ G +L + + NG+L IR R+E G S G Y
Sbjct: 57 QPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYE 116
Query: 206 CQASSTEG-SATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
C A + G + ++ V P+ + C P L +W ++
Sbjct: 117 CVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPL-ITWEKN 175
Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTV----- 319
+ I R +L G L++ + +D G + CV SN S A LTV
Sbjct: 176 RV---PIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGS 232
Query: 320 -LYPAQVTAMPPET-PLPIGMPGVIRCPVRANPPLLFVSWTK-DGKALQLDKFPGWSQGT 376
Y + PE L + V+ C NP + VSW++ DG+ + ++ G
Sbjct: 233 GAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPI-VSWSRLDGRPIGVE---GIQVLG 288
Query: 377 EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 436
G+LII+ G Y C + R++++AP F++ P + + G
Sbjct: 289 TGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHP-QSISRPAGTTA 347
Query: 437 LIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVA 493
+ C AQG+PPP V+W K G+ L V ++NS+L + + E ++C A N+
Sbjct: 348 MFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAG 407
Query: 494 RVATSTNVYVLGTS--PHVVTNVSVVALPK-GANVSW-EPGFDGGYLQRFSVWYTPLAKR 549
S + VL P NV V++ VSW EP + + + + A
Sbjct: 408 SSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADP 467
Query: 550 PDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTT 609
P+ + + AV LV L+P T Y F + A G+ S +PT
Sbjct: 468 PELEYQE----AVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSAS---------VPTL 514
Query: 610 PAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEV 669
+ G P PPPLS V V + L W+P + + G+ L R S+
Sbjct: 515 ASTLGEAPA--PPPLS-----VRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFT 567
Query: 670 LDPAVAGTETELLVPGLIKDVLYEFRLVAF 699
+ GT + + L +YE +L+A+
Sbjct: 568 GPILLPGTVSSYNLSQLDPTAVYEVKLLAY 597
Score = 69.3 bits (168), Expect = 2e-11
Identities = 79/263 (30%), Positives = 112/263 (42%), Gaps = 24/263 (9%)
Query: 77 IDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPP 136
ID D L KG LQI GLR ED G + C + +I ++G+ LTV+
Sbjct: 179 IDTDNERYTLLPKGV-LQITGLRAEDGGIFHC----VASNIASIRISHGA--RLTVSGSG 231
Query: 137 QFQETPPAVLEVQELEPVT------LRCVARGSPLPHVTW-KLRGKDLGQGQGQVQVQNG 189
PA+L E +T L CVA G+P P V+W +L G+ +G +G + G
Sbjct: 232 SGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGV-EGIQVLGTG 290
Query: 190 TLRIRRVERGSSGVYTCQAS--STEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
L I V SGVY C A+ T T +L+V P V P++ + A
Sbjct: 291 NLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFT 350
Query: 248 CHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNG 306
C A+ P +W ++ + VR+ + S L + P+D Y CV N
Sbjct: 351 CQAQGEPPP-HVTWLKNG----QVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENS 405
Query: 307 LLHPPSASAYLTVLYPAQVTAMP 329
ASA LTVL+ + P
Sbjct: 406 -AGSSQASARLTVLWAEGLPGPP 427
Score = 33.9 bits (76), Expect = 0.94
Identities = 26/100 (26%), Positives = 44/100 (44%), Gaps = 9/100 (9%)
Query: 406 PSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQA 463
P+P + A AF P ++ G+ +++ C +G PP ++W K G L +
Sbjct: 30 PAPSEGLGHSAELAFAVEPSDDVAVP-GQPIVLDCRVEGTPPVRITWRKNGVELPESTHS 88
Query: 464 QVDSNSSLILRPLTKEA------HGHWECSASNAVARVAT 497
+ +N SL++R E G +EC A N V +
Sbjct: 89 TLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVS 128
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 119 bits (298), Expect = 2e-26
Identities = 165/669 (24%), Positives = 246/669 (36%), Gaps = 93/669 (13%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I
Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191
Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G Y C ++ G + +L VL P V P N V C A P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
T W +D+ + + R I D +L++ D G YTCV N ++ ASA
Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304
Query: 316 YLTVLY---PAQVTAMPPETPLPIGMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPG 371
LTV P P + + +G +C NP P +F W ++G L +
Sbjct: 305 TLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQP 362
Query: 372 ------WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIE 422
+S G L I +G Y C N G T VT V+ PP I
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422
Query: 423 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ---AQVDSNSSLILRPLTKE 479
+ V ++ C A G P P + W K G + Q + N L +R
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 480 AHGHWECSASNAVARVATSTNVYV----------LGTSPHVVTNVSVVALPKGANV---- 525
G + C AS S + V T P+++ S + P+ +V
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNT 540
Query: 526 ---SWEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHT 578
SW+P + G TP + + H W ++A V + GL+P+
Sbjct: 541 VTLSWQPNLNSG--------ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNA 592
Query: 579 QYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP- 636
Y F V A N G S+I S P + P + G+ ++ L ++ + P
Sbjct: 593 IYLFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPT 648
Query: 637 ----RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVP 684
+ +HW + + + GY + R G W EV PA + +++P
Sbjct: 649 VLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIP 703
Query: 685 GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVC 744
L K V YE + F F S T LE PS PQ V G
Sbjct: 704 DLRKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG-- 753
Query: 745 FLGVAVLVS 753
G A+LVS
Sbjct: 754 -NGTAILVS 761
Score = 102 bits (255), Expect = 2e-21
Identities = 138/610 (22%), Positives = 232/610 (38%), Gaps = 55/610 (9%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G
Sbjct: 28 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
+L R+ G GVY C A + G A +A+ + + P + V +
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
+ C T SW +D + R+ I G L + T+ DAG Y CV
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202
Query: 303 PSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGK 362
+N + S A LTVL P + + +C R +P + V W KD
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVRWRKDDG 261
Query: 363 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKA-PPAFI 421
L ++ T + G+ +G Y+C N +G A S V + + PP F+
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
Query: 422 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSL 471
+P+++ +GR + C A G+P P + W + G + V L
Sbjct: 319 VKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 472 ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGF 531
+ + + G++ C N + T + V V+ + + +G V+
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAV 432
Query: 532 DGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSV 584
DG ++ +P+ R D V ++ L G+ +Y +++
Sbjct: 433 DGTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTC 489
Query: 585 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 644
+A G +S + G+P P P P IP S P V + V L W
Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQ 546
Query: 645 PPELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGS 702
P Y++E + G W+ + V TET + GL + +Y F + A
Sbjct: 547 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAY 604
Query: 703 FVSDPSNTAN 712
+SDPS ++
Sbjct: 605 GISDPSQISD 614
Score = 65.5 bits (158), Expect = 3e-10
Identities = 65/236 (27%), Positives = 96/236 (40%), Gaps = 16/236 (6%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
G +V C+ A P I W R G +F Y P P R + + L
Sbjct: 329 GRTVTFQCE----ATGNPQPAIFWRREGSQNLLFS----YQP---PQSSSRFSVSQTGDL 377
Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
I ++ D G+Y C+ + I + + V + PP P V
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQTVAVDGT 435
Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQV-QVQNGTLRIRRVERGSSGVYTCQASSTE 212
L CVA GSP+P + W+ G + ++ Q++NG L+IR + G +G YTC AS+
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN-LTYSWFQDNIN 267
G AT + + V V V PP+ + N N +T SW Q N+N
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW-QPNLN 550
Score = 41.2 bits (95), Expect = 0.006
Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%)
Query: 784 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 842
TG S S GS + S K +P + + W D P HP P S+ +
Sbjct: 1046 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1105
Query: 843 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 889
E C P R + E E TP R A S + S
Sbjct: 1106 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1160
Query: 890 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 930
SP QP+ C E+ PV+PPP PP P+ P Y+S P
Sbjct: 1161 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1217
Query: 931 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 988
+M D D P EE M TRR LR E P S L +V G+
Sbjct: 1218 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1269
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 119 bits (298), Expect = 2e-26
Identities = 165/669 (24%), Positives = 246/669 (36%), Gaps = 93/669 (13%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I
Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191
Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G Y C ++ G + +L VL P V P N V C A P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
T W +D+ + + R I D +L++ D G YTCV N ++ ASA
Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304
Query: 316 YLTVLY---PAQVTAMPPETPLPIGMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPG 371
LTV P P + + +G +C NP P +F W ++G L +
Sbjct: 305 TLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQP 362
Query: 372 ------WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIE 422
+S G L I +G Y C N G T VT V+ PP I
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422
Query: 423 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ---AQVDSNSSLILRPLTKE 479
+ V ++ C A G P P + W K G + Q + N L +R
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 480 AHGHWECSASNAVARVATSTNVYV----------LGTSPHVVTNVSVVALPKGANV---- 525
G + C AS S + V T P+++ S + P+ +V
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNT 540
Query: 526 ---SWEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHT 578
SW+P + G TP + + H W ++A V + GL+P+
Sbjct: 541 VTLSWQPNLNSG--------ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNA 592
Query: 579 QYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP- 636
Y F V A N G S+I S P + P + G+ ++ L ++ + P
Sbjct: 593 IYLFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPT 648
Query: 637 ----RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVP 684
+ +HW + + + GY + R G W EV PA + +++P
Sbjct: 649 VLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIP 703
Query: 685 GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVC 744
L K V YE + F F S T LE PS PQ V G
Sbjct: 704 DLRKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG-- 753
Query: 745 FLGVAVLVS 753
G A+LVS
Sbjct: 754 -NGTAILVS 761
Score = 102 bits (255), Expect = 2e-21
Identities = 138/610 (22%), Positives = 232/610 (38%), Gaps = 55/610 (9%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G
Sbjct: 28 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
+L R+ G GVY C A + G A +A+ + + P + V +
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
+ C T SW +D + R+ I G L + T+ DAG Y CV
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202
Query: 303 PSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGK 362
+N + S A LTVL P + + +C R +P + V W KD
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVRWRKDDG 261
Query: 363 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKA-PPAFI 421
L ++ T + G+ +G Y+C N +G A S V + + PP F+
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
Query: 422 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSL 471
+P+++ +GR + C A G+P P + W + G + V L
Sbjct: 319 VKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 472 ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGF 531
+ + + G++ C N + T + V V+ + + +G V+
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAV 432
Query: 532 DGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSV 584
DG ++ +P+ R D V ++ L G+ +Y +++
Sbjct: 433 DGTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTC 489
Query: 585 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 644
+A G +S + G+P P P P IP S P V + V L W
Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQ 546
Query: 645 PPELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGS 702
P Y++E + G W+ + V TET + GL + +Y F + A
Sbjct: 547 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAY 604
Query: 703 FVSDPSNTAN 712
+SDPS ++
Sbjct: 605 GISDPSQISD 614
Score = 65.5 bits (158), Expect = 3e-10
Identities = 65/236 (27%), Positives = 96/236 (40%), Gaps = 16/236 (6%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
G +V C+ A P I W R G +F Y P P R + + L
Sbjct: 329 GRTVTFQCE----ATGNPQPAIFWRREGSQNLLFS----YQP---PQSSSRFSVSQTGDL 377
Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
I ++ D G+Y C+ + I + + V + PP P V
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQTVAVDGT 435
Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQV-QVQNGTLRIRRVERGSSGVYTCQASSTE 212
L CVA GSP+P + W+ G + ++ Q++NG L+IR + G +G YTC AS+
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN-LTYSWFQDNIN 267
G AT + + V V V PP+ + N N +T SW Q N+N
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW-QPNLN 550
Score = 41.2 bits (95), Expect = 0.006
Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%)
Query: 784 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 842
TG S S GS + S K +P + + W D P HP P S+ +
Sbjct: 1101 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1160
Query: 843 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 889
E C P R + E E TP R A S + S
Sbjct: 1161 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1215
Query: 890 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 930
SP QP+ C E+ PV+PPP PP P+ P Y+S P
Sbjct: 1216 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1272
Query: 931 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 988
+M D D P EE M TRR LR E P S L +V G+
Sbjct: 1273 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1324
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 119 bits (298), Expect = 2e-26
Identities = 165/669 (24%), Positives = 246/669 (36%), Gaps = 93/669 (13%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I
Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191
Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G Y C ++ G + +L VL P V P N V C A P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
T W +D+ + + R I D +L++ D G YTCV N ++ ASA
Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304
Query: 316 YLTVLY---PAQVTAMPPETPLPIGMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPG 371
LTV P P + + +G +C NP P +F W ++G L +
Sbjct: 305 TLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQP 362
Query: 372 ------WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIE 422
+S G L I +G Y C N G T VT V+ PP I
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422
Query: 423 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ---AQVDSNSSLILRPLTKE 479
+ V ++ C A G P P + W K G + Q + N L +R
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 480 AHGHWECSASNAVARVATSTNVYV----------LGTSPHVVTNVSVVALPKGANV---- 525
G + C AS S + V T P+++ S + P+ +V
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNT 540
Query: 526 ---SWEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHT 578
SW+P + G TP + + H W ++A V + GL+P+
Sbjct: 541 VTLSWQPNLNSG--------ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNA 592
Query: 579 QYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP- 636
Y F V A N G S+I S P + P + G+ ++ L ++ + P
Sbjct: 593 IYLFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPT 648
Query: 637 ----RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVP 684
+ +HW + + + GY + R G W EV PA + +++P
Sbjct: 649 VLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIP 703
Query: 685 GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVC 744
L K V YE + F F S T LE PS PQ V G
Sbjct: 704 DLRKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG-- 753
Query: 745 FLGVAVLVS 753
G A+LVS
Sbjct: 754 -NGTAILVS 761
Score = 102 bits (255), Expect = 2e-21
Identities = 138/610 (22%), Positives = 232/610 (38%), Gaps = 55/610 (9%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G
Sbjct: 28 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
+L R+ G GVY C A + G A +A+ + + P + V +
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
+ C T SW +D + R+ I G L + T+ DAG Y CV
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202
Query: 303 PSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGK 362
+N + S A LTVL P + + +C R +P + V W KD
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVRWRKDDG 261
Query: 363 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKA-PPAFI 421
L ++ T + G+ +G Y+C N +G A S V + + PP F+
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
Query: 422 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSL 471
+P+++ +GR + C A G+P P + W + G + V L
Sbjct: 319 VKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 472 ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGF 531
+ + + G++ C N + T + V V+ + + +G V+
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAV 432
Query: 532 DGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSV 584
DG ++ +P+ R D V ++ L G+ +Y +++
Sbjct: 433 DGTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTC 489
Query: 585 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 644
+A G +S + G+P P P P IP S P V + V L W
Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQ 546
Query: 645 PPELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGS 702
P Y++E + G W+ + V TET + GL + +Y F + A
Sbjct: 547 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAY 604
Query: 703 FVSDPSNTAN 712
+SDPS ++
Sbjct: 605 GISDPSQISD 614
Score = 65.5 bits (158), Expect = 3e-10
Identities = 65/236 (27%), Positives = 96/236 (40%), Gaps = 16/236 (6%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
G +V C+ A P I W R G +F Y P P R + + L
Sbjct: 329 GRTVTFQCE----ATGNPQPAIFWRREGSQNLLFS----YQP---PQSSSRFSVSQTGDL 377
Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
I ++ D G+Y C+ + I + + V + PP P V
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQTVAVDGT 435
Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQV-QVQNGTLRIRRVERGSSGVYTCQASSTE 212
L CVA GSP+P + W+ G + ++ Q++NG L+IR + G +G YTC AS+
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN-LTYSWFQDNIN 267
G AT + + V V V PP+ + N N +T SW Q N+N
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW-QPNLN 550
Score = 42.0 bits (97), Expect = 0.003
Identities = 65/238 (27%), Positives = 80/238 (33%), Gaps = 47/238 (19%)
Query: 784 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 842
TG S S GS + S K +P + + W D P HP P S+ +
Sbjct: 1057 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1116
Query: 843 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 889
E C P R T E E TP R A S + S
Sbjct: 1117 VDESYDQEMPCPVPPAR-----TYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1171
Query: 890 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 930
SP QP+ C E+ PV+PPP PP P+ P Y+S P
Sbjct: 1172 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1228
Query: 931 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 988
+M D D P EE M TRR LR E P S L +V G+
Sbjct: 1229 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1280
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 119 bits (298), Expect = 2e-26
Identities = 165/669 (24%), Positives = 246/669 (36%), Gaps = 93/669 (13%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I
Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191
Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G Y C ++ G + +L VL P V P N V C A P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
T W +D+ + + R I D +L++ D G YTCV N ++ ASA
Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304
Query: 316 YLTVLY---PAQVTAMPPETPLPIGMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPG 371
LTV P P + + +G +C NP P +F W ++G L +
Sbjct: 305 TLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQP 362
Query: 372 ------WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIE 422
+S G L I +G Y C N G T VT V+ PP I
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422
Query: 423 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ---AQVDSNSSLILRPLTKE 479
+ V ++ C A G P P + W K G + Q + N L +R
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 480 AHGHWECSASNAVARVATSTNVYV----------LGTSPHVVTNVSVVALPKGANV---- 525
G + C AS S + V T P+++ S + P+ +V
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNT 540
Query: 526 ---SWEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHT 578
SW+P + G TP + + H W ++A V + GL+P+
Sbjct: 541 VTLSWQPNLNSG--------ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNA 592
Query: 579 QYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP- 636
Y F V A N G S+I S P + P + G+ ++ L ++ + P
Sbjct: 593 IYLFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPT 648
Query: 637 ----RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVP 684
+ +HW + + + GY + R G W EV PA + +++P
Sbjct: 649 VLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIP 703
Query: 685 GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVC 744
L K V YE + F F S T LE PS PQ V G
Sbjct: 704 DLRKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG-- 753
Query: 745 FLGVAVLVS 753
G A+LVS
Sbjct: 754 -NGTAILVS 761
Score = 102 bits (255), Expect = 2e-21
Identities = 138/610 (22%), Positives = 232/610 (38%), Gaps = 55/610 (9%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G
Sbjct: 28 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
+L R+ G GVY C A + G A +A+ + + P + V +
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
+ C T SW +D + R+ I G L + T+ DAG Y CV
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202
Query: 303 PSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGK 362
+N + S A LTVL P + + +C R +P + V W KD
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVRWRKDDG 261
Query: 363 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKA-PPAFI 421
L ++ T + G+ +G Y+C N +G A S V + + PP F+
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
Query: 422 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSL 471
+P+++ +GR + C A G+P P + W + G + V L
Sbjct: 319 VKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 472 ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGF 531
+ + + G++ C N + T + V V+ + + +G V+
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAV 432
Query: 532 DGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSV 584
DG ++ +P+ R D V ++ L G+ +Y +++
Sbjct: 433 DGTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTC 489
Query: 585 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 644
+A G +S + G+P P P P IP S P V + V L W
Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQ 546
Query: 645 PPELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGS 702
P Y++E + G W+ + V TET + GL + +Y F + A
Sbjct: 547 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAY 604
Query: 703 FVSDPSNTAN 712
+SDPS ++
Sbjct: 605 GISDPSQISD 614
Score = 65.5 bits (158), Expect = 3e-10
Identities = 65/236 (27%), Positives = 96/236 (40%), Gaps = 16/236 (6%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
G +V C+ A P I W R G +F Y P P R + + L
Sbjct: 329 GRTVTFQCE----ATGNPQPAIFWRREGSQNLLFS----YQP---PQSSSRFSVSQTGDL 377
Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
I ++ D G+Y C+ + I + + V + PP P V
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQTVAVDGT 435
Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQV-QVQNGTLRIRRVERGSSGVYTCQASSTE 212
L CVA GSP+P + W+ G + ++ Q++NG L+IR + G +G YTC AS+
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN-LTYSWFQDNIN 267
G AT + + V V V PP+ + N N +T SW Q N+N
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW-QPNLN 550
Score = 42.0 bits (97), Expect = 0.003
Identities = 65/238 (27%), Positives = 80/238 (33%), Gaps = 47/238 (19%)
Query: 784 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 842
TG S S GS + S K +P + + W D P HP P S+ +
Sbjct: 1110 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1169
Query: 843 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 889
E C P R T E E TP R A S + S
Sbjct: 1170 VDESYDQEMPCPVPPAR-----TYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1224
Query: 890 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 930
SP QP+ C E+ PV+PPP PP P+ P Y+S P
Sbjct: 1225 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1281
Query: 931 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 988
+M D D P EE M TRR LR E P S L +V G+
Sbjct: 1282 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1333
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 118 bits (296), Expect = 3e-26
Identities = 133/522 (25%), Positives = 208/522 (39%), Gaps = 50/522 (9%)
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQ 207
V E + + L CV G VTW RG L + Q LR+ V SG Y C+
Sbjct: 2936 VTEGQTLDLNCVVPGQAHAQVTWYKRGGSL---PARHQTHGSQLRLHLVSPADSGEYVCR 2992
Query: 208 ASSTEGSATHATQLLVLGP----------PVIVVPPKNSTVNASQDVSLACHAEAYPANL 257
A+S G A+ + + P PVI + P +STV QD S C A +
Sbjct: 2993 AASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPI 3052
Query: 258 TYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSASAY 316
+ W N L+ V I +GS + ++ T+P + G Y CV SN S
Sbjct: 3053 SLEWKTRN------QELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSV-VN 3105
Query: 317 LTVLYPAQVTAMPPETP--LPIGMPGVIRCPVRANPPLLFVSWTK-DGKALQLDKFPGWS 373
L+V P V+ + PE P + +G + C V A P WT+ +L++
Sbjct: 3106 LSVHGPPTVSVL-PEGPVWVKVGKAVTLEC-VSAGEPRSSARWTRISSTPAKLEQRTYGL 3163
Query: 374 QGTEGSLIIALGNEDALGEYSCTPYNSLGTAGP--SPVTRVLLKAPPA-FIERPKEEYFQ 430
+ L I+ G Y C N+LGTA + AP A ++ + E
Sbjct: 3164 MDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTV 3223
Query: 431 EVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASN 490
E G + CSA G P P + W+K+ L Q +++ + +LI+ + ++ G + C+A++
Sbjct: 3224 EAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGD-TLIIPRVAQQDSGQYICNATS 3282
Query: 491 AVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRP 550
A +T + + + P+ T ++ G V LQ + PL +
Sbjct: 3283 PAGH-AEATIILHVESPPYATTVPEHASVQAGETVQ---------LQCLAHGTPPLTFQW 3332
Query: 551 DRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSG-PFSEIVLSAPEG-LPT 608
R+ A L P ++ NK+GS F+++++ P G LP
Sbjct: 3333 SRVGSSLPGRATARNEL-LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPA 3391
Query: 609 TPAAPGLPPTEIPPPLSPPRGL-------VAVRTPRGVLLHW 643
T G PT P + + AV + RG L W
Sbjct: 3392 TSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRW 3433
Score = 103 bits (256), Expect = 1e-21
Identities = 131/516 (25%), Positives = 202/516 (39%), Gaps = 77/516 (14%)
Query: 10 LSLVISQGADGRGKPEV----VSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLP 65
+ +++ GA G P+V + AG + L C A P I W + LP
Sbjct: 3198 VEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCS----ATGSPAPTIHWSKLRSPLP 3253
Query: 66 IFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANG 125
+ R++ D +L I + +D G Y C H
Sbjct: 3254 -------WQHRLEGD-----------TLIIPRVAQQDSGQYICNATSPAGHAE------- 3288
Query: 126 SWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQ 185
+ + L V SPP + T P VQ E V L+C+A G+P W G L G+
Sbjct: 3289 ATIILHVESPP-YATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL---PGRAT 3344
Query: 186 VQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPP--------------VIVV 231
+N L R SG Y C+ ++ GSA QLLV GPP + V
Sbjct: 3345 ARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQV 3404
Query: 232 PPKNSTVNASQDVSLACHAEAYPAN--LTYSWFQDNINVFHISRLQPRVRILVDGSLRLL 289
P+ T + V C A P++ WF++ + P + DG LR+
Sbjct: 3405 TPQLETKSIGASVEFHC---AVPSDRGTQLRWFKEGGQL-------PPGHSVQDGVLRIQ 3454
Query: 290 ATQPDDAGCYTCVPSNGLLHPPSASAYLTV--LYPAQVTAMPPETPLPIGMPGVIRCPVR 347
G Y C ++G ASA L + L + + +G C
Sbjct: 3455 NLDQSCQGTYIC-QAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLAL 3513
Query: 348 ANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPS 407
+P V+W+K G L+ PG Q I + DA G+Y CT N+ GT
Sbjct: 3514 GDPKPQ-VTWSKVGGHLR----PGIVQSGGVVRIAHVELADA-GQYRCTATNAAGTTQSH 3567
Query: 408 PVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDS 467
+ +L++A P I P+E G + PC A G P P +SW+K+ L ++++
Sbjct: 3568 VL--LLVQALPQ-ISMPQEVRVP-AGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE- 3622
Query: 468 NSSLILRPLTKEAHGHWECSASNAVARVATSTNVYV 503
N+ L+L + + G + C+A+N +V ++ V
Sbjct: 3623 NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
Score = 102 bits (254), Expect = 2e-21
Identities = 109/404 (26%), Positives = 162/404 (40%), Gaps = 41/404 (10%)
Query: 136 PQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRR 195
PQ Q A L V+ TLRC A GSP P + W L Q +++ TL I R
Sbjct: 3212 PQVQ-AEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPL---PWQHRLEGDTLIIPR 3267
Query: 196 VERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
V + SG Y C A+S G A L V PP P++++V A + V L C A P
Sbjct: 3268 VAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPP 3327
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
LT+ W + + P + L P+D+G Y C +N + SA A
Sbjct: 3328 -LTFQWSR-------VGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKV---GSAEA 3376
Query: 316 YLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVS----------------WTK 359
+ +L ++ P T +P G ++ + + S W K
Sbjct: 3377 FAQLLVQGPPGSL-PATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFK 3435
Query: 360 DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 419
+G L PG S +G L I ++ G Y C + G A S V+ P
Sbjct: 3436 EGGQLP----PGHSV-QDGVLRIQNLDQSCQGTYICQAHGPWGKAQAS-AQLVIQALPSV 3489
Query: 420 FIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKE 479
I VG + C A GDP P V+W+KVG L+ V S + + +
Sbjct: 3490 LINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLR-PGIVQSGGVVRIAHVELA 3548
Query: 480 AHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGA 523
G + C+A+NA T ++V +L + ++ V +P G+
Sbjct: 3549 DAGQYRCTATNAAG--TTQSHVLLLVQALPQISMPQEVRVPAGS 3590
Score = 92.8 bits (229), Expect = 2e-18
Identities = 129/525 (24%), Positives = 197/525 (37%), Gaps = 58/525 (11%)
Query: 133 NSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTL 191
N P E PA V + +LRC GSP + W G+ + G Q + Q L
Sbjct: 1673 NQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQ-RHQGSEL 1731
Query: 192 RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPP-----VIVVPPKNSTVNASQDVSL 246
V+ +GVY C + S T +LLV P V V ++ +V DV+
Sbjct: 1732 HFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTF 1791
Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN- 305
C A++ T W + H +L R + +G L + Q DAG Y C SN
Sbjct: 1792 ICTAKSKSPAYTLVWTR-----LHNGKLPTRA-MDFNGILTIRNVQLSDAGTYVCTGSNM 1845
Query: 306 -------GLLHPPSA---SAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANP-PLLF 354
LH ++ SA + ++P Q+T P G RC +P P L
Sbjct: 1846 FAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQP-------GQLAEFRCSATGSPTPTL- 1897
Query: 355 VSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLL 414
WT G QL P +Q G L + +Y C ++S G V V
Sbjct: 1898 -EWT-GGPGGQL---PAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHG 1952
Query: 415 KAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSN--SSLI 472
P ++ E GR + + C A G P ++W K G L QA+ + ++L+
Sbjct: 1953 GGGPR-VQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLL 2011
Query: 473 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTS----PHVVTNVSVVALPKGANVSWE 528
+ +T G + C A++ V VL S P V S ++ +G +
Sbjct: 2012 IPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLN 2071
Query: 529 PGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQN 588
G + + WY P V + L +P + P ++ +N
Sbjct: 2072 CVVAGSAHAQVT-WYRRGGSLPPH---------TQVHGSRLRLPQVSPADSGEYVCRVEN 2121
Query: 589 KLGSGP-FSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVA 632
GSGP + I +S G + P+ +P + P + P VA
Sbjct: 2122 --GSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVA 2164
Score = 92.0 bits (227), Expect = 3e-18
Identities = 99/448 (22%), Positives = 171/448 (38%), Gaps = 52/448 (11%)
Query: 89 KGASLQIEGLRVEDQGWYECRVFFLDQHIPED-----DFANGSWVHLTVNSPPQFQETPP 143
+G+ L++ + D G Y CRV + + + S VH+ P
Sbjct: 2774 RGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEP 2833
Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGV 203
+ V E + + L+CV G VTW RG +L + QV LR+ +V SG
Sbjct: 2834 SSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNL---PARHQVHGPLLRLNQVSPADSGE 2890
Query: 204 YTCQASSTEGSATHATQLLVLGP----PV--------IVVPPKNSTVNASQDVSLACHAE 251
Y+CQ + + G+ A+ L+ + P P+ I + +S V Q + L C
Sbjct: 2891 YSCQVTGSSGT-LEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVP 2949
Query: 252 AYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG----- 306
A+ +W++ ++ P LRL P D+G Y C ++G
Sbjct: 2950 G-QAHAQVTWYKRGGSL-------PARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQ 3001
Query: 307 -----LLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDG 361
+ PPS + + P ++ PP + + G +C + + + W
Sbjct: 3002 EASFTVTVPPSEGSSYRLRSPV-ISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRN 3060
Query: 362 KALQLDKFPGWSQGTEGSLIIALGNEDA-LGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF 420
+ L+ GS+I +G + G Y C N+ G A V + + PP
Sbjct: 3061 QELE----DNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVA--QSVVNLSVHGPPTV 3114
Query: 421 IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQ-----VDSNSSLILRP 475
P+ + +VG+ + + C + G+P WT++ Q +DS++ L +
Sbjct: 3115 SVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISS 3174
Query: 476 LTKEAHGHWECSASNAVARVATSTNVYV 503
G + C A NA+ V V
Sbjct: 3175 AKPSDAGTYVCLAQNALGTAQKQVEVIV 3202
Score = 91.3 bits (225), Expect = 5e-18
Identities = 121/449 (26%), Positives = 179/449 (39%), Gaps = 67/449 (14%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQ 149
G L++ + DQ Y CR H + +H+ P+ Q +P +V
Sbjct: 1915 GGILRLPAVEPTDQAQYLCRA-----HSSAGQQVARAVLHVHGGGGPRVQVSPERT-QVH 1968
Query: 150 ELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQAS 209
V L C A G P +TW+ G L + TL I + +G Y C A+
Sbjct: 1969 AGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVAT 2028
Query: 210 STEGSATHATQLLVL-----GPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
S G+A Q++VL PP + + + +V Q + L C A A+ +W++
Sbjct: 2029 SPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNC-VVAGSAHAQVTWYRR 2087
Query: 265 NINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPA 323
L P + V GS LRL P D+G Y C NG P AS ++VL+
Sbjct: 2088 G------GSLPPHTQ--VHGSRLRLPQVSPADSGEYVCRVENG-SGPKEASITVSVLHGT 2138
Query: 324 QVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLD-KFPGWSQG------- 375
+ P TP +PG R P+R P V+ +G+ L L+ PG +
Sbjct: 2139 H--SGPSYTP----VPGSTR-PIRIEPSSSHVA---EGQTLDLNCVVPGQAHAQVTWHKR 2188
Query: 376 ---------TEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVT-RVLLKA-------P 417
T GSL+ + GEY C + +GT+GP + V ++A P
Sbjct: 2189 GGSLPARHQTHGSLLRLHQVTPADSGEYVC---HVVGTSGPLEASVLVTIEASVIPGPIP 2245
Query: 418 PAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLT 477
P IE + G+ L + C G V+W K G L + QV + I +
Sbjct: 2246 PVRIESSSSTVAE--GQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASP 2303
Query: 478 KEAHGHWECSASNAVARVATSTNVYVLGT 506
+A G + C ASN + S V V GT
Sbjct: 2304 ADA-GQYVCRASNG---MEASITVTVTGT 2328
Score = 88.2 bits (217), Expect = 4e-17
Identities = 160/668 (23%), Positives = 239/668 (35%), Gaps = 123/668 (18%)
Query: 11 SLVISQGADGRGKPEVVSV-----VGRAGESVVLG--CDLLPPAGRPPLHVIEWLRFGFL 63
SL+++ G G V SV + + +VV G DL R P +I W + G
Sbjct: 2612 SLIVT--IQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGS 2669
Query: 64 LPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFA 123
LP Q G+ L++ + V D G Y CR + +I + +
Sbjct: 2670 LPSRHQ------------------THGSHLRLHQMSVADSGEYVCRA---NNNIDALEAS 2708
Query: 124 NGSWVHLTVNSPPQFQETPPAVLE-----VQELEPVTLRCVARGSPLPHVTWKLRGKDLG 178
V + SP + P +E V E E + L CV G VTW RG G
Sbjct: 2709 IVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRG---G 2765
Query: 179 QGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVL-------------- 224
Q + LR+ V SG Y C+ + G A+ L+ +
Sbjct: 2766 SLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSG-PLEASVLVTIEASGSSAVHVPAPG 2824
Query: 225 GPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDG 284
G P I + P +S V Q + L C A+ +W + N+ P +
Sbjct: 2825 GAPPIRIEPSSSRVAEGQTLDLKCVVPG-QAHAQVTWHKRGGNL-------PARHQVHGP 2876
Query: 285 SLRLLATQPDDAGCYTC--VPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGV- 341
LRL P D+G Y+C S+G L AS +T+ P +P PI PG+
Sbjct: 2877 LLRLNQVSPADSGEYSCQVTGSSGTL---EASVLVTI---------EPSSPGPIPAPGLA 2924
Query: 342 -------------------IRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 382
+ C V V+W K G +L P Q L +
Sbjct: 2925 QPIYIEASSSHVTEGQTLDLNCVVPGQAHAQ-VTWYKRGGSL-----PARHQTHGSQLRL 2978
Query: 383 ALGNEDALGEYSCTPYNSLG---------TAGPSPVTRVLLKAPPAFIERPKEEYFQEVG 433
L + GEY C + G T PS + L++P I+ P Q G
Sbjct: 2979 HLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQ--G 3036
Query: 434 RELLIPCSAQGDPPPV-VSWTKVGRGLQGQAQVDSNSSLILRPLTKEA-HGHWECSASNA 491
++ C P+ + W + L+ + N S+I T+ + HG + C ASNA
Sbjct: 3037 QDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNA 3096
Query: 492 VARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPD 551
+ N+ V G V V + G V+ E G R S +T ++ P
Sbjct: 3097 YGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGE--PRSSARWTRISSTPA 3154
Query: 552 RMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPA 611
++ L A L + +P + LAQN LG+ V+ + T
Sbjct: 3155 KLEQRTYGLM--DSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVI-----VDTGAM 3207
Query: 612 APGLPPTE 619
APG P +
Sbjct: 3208 APGAPQVQ 3215
Score = 88.2 bits (217), Expect = 4e-17
Identities = 108/466 (23%), Positives = 172/466 (36%), Gaps = 56/466 (12%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANG-SWVHLTVNSPPQFQETPPAVLEV 148
G+ + I G R + G Y C + + + S V+L+V+ PP P + V
Sbjct: 3073 GSIITIVGTRPSNHGTYRC--------VASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWV 3124
Query: 149 QELEPVTLRCVARGSPLPHVTW---KLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYT 205
+ + VTL CV+ G P W L Q + + L+I + +G Y
Sbjct: 3125 KVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYV 3184
Query: 206 CQASSTEGSATHATQLLV------LGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTY 259
C A + G+A +++V G P + TV A +L C A PA
Sbjct: 3185 CLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPA---- 3240
Query: 260 SWFQDNINVFHISRLQ---PRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAY 316
H S+L+ P L +L + D+G Y C ++ H A+
Sbjct: 3241 -------PTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGH-AEATII 3292
Query: 317 LTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGT 376
L V P T +P + G ++C PPL F W++ G +L PG +
Sbjct: 3293 LHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTF-QWSRVGSSL-----PGRATAR 3346
Query: 377 EGSLIIALGNEDALGEYSCTPYNSLGTA------------GPSPVTRVLLKAPPAFIERP 424
L + G Y C N +G+A G P T + + P P
Sbjct: 3347 NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTP 3406
Query: 425 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHW 484
+ E + +G + C+ D + W K G L V + L ++ L + G +
Sbjct: 3407 QLE-TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSV-QDGVLRIQNLDQSCQGTY 3464
Query: 485 ECSASNAVARVATSTNVYVLGTSPHVVTNV--SVVALPKGANVSWE 528
C A + S + V+ P V+ N+ SV + G V +E
Sbjct: 3465 ICQAHGPWGKAQASAQL-VIQALPSVLINIRTSVQTVVVGHAVEFE 3509
Score = 85.1 bits (209), Expect = 4e-16
Identities = 113/419 (26%), Positives = 160/419 (38%), Gaps = 50/419 (11%)
Query: 93 LQIEGLRVEDQGWYEC---RVFFLDQHIPEDDFANGSWVHLTVN---SPPQFQETPPAVL 146
L I +++ D G Y C +F +DQ + +H+ + S P PP L
Sbjct: 1825 LTIRNVQLSDAGTYVCTGSNMFAMDQ--------GTATLHVQASGTLSAPVVSIHPPQ-L 1875
Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTC 206
VQ + RC A GSP P + W G GQ + Q+ G LR+ VE Y C
Sbjct: 1876 TVQPGQLAEFRCSATGSPTPTLEWT--GGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLC 1933
Query: 207 QASSTEGSATHATQLLVL--GPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
+A S+ G L V G P + V P+ + V+A + V L C A P + T +W ++
Sbjct: 1934 RAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVP-SATITWRKE 1992
Query: 265 NINVFHISRLQPRVRILVDGSLRLL--ATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYP 322
L P+ R LL A DAG Y CV ++ +A A + V+
Sbjct: 1993 G------GSLPPQARSERTDIATLLIPAITTADAGFYLCVATS---PAGTAQARIQVVVL 2043
Query: 323 AQVTAMPPETPLPIGMPGV-------IRCPVRANPPLLFVSWTKDGKALQLD-------- 367
+ A PP + P V + C V A V+W + G +L
Sbjct: 2044 SASDASPPPVKIESSSPSVTEGQTLDLNCVV-AGSAHAQVTWYRRGGSLPPHTQVHGSRL 2102
Query: 368 KFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEE 427
+ P S G + + N E S T GT T V P IE P
Sbjct: 2103 RLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIE-PSSS 2161
Query: 428 YFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWEC 486
+ E G+ L + C G V+W K G L + Q S L L +T G + C
Sbjct: 2162 HVAE-GQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQT-HGSLLRLHQVTPADSGEYVC 2218
Score = 65.5 bits (158), Expect = 3e-10
Identities = 98/396 (24%), Positives = 148/396 (37%), Gaps = 57/396 (14%)
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202
P+ +V E + + L CV G VTW RG G + Q LR+ + SG
Sbjct: 2347 PSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRG---GSLPVRHQTHGSLLRLYQASPADSG 2403
Query: 203 VYTCQASSTEGSATHATQLLVLGP----------PVIVVPPKNSTVNASQDVSLACHAEA 252
Y C+ + A+ L+ + P P + + +S V Q + L C A
Sbjct: 2404 EYVCRVLGS-SVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNC-LVA 2461
Query: 253 YPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTC--VPSNG--- 306
A+ +W + ++ R V GS LRLL P D+G Y C V S+G
Sbjct: 2462 GQAHAQVTWHKRGGSL--------PARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQE 2513
Query: 307 ------LLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKD 360
+ S S V YP ++ + L G + C V + P ++W K
Sbjct: 2514 ASVLVTIQQRLSGSHSQGVAYPVRIES--SSASLANGHTLDLNCLVASQAPHT-ITWYKR 2570
Query: 361 GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPV--------TRV 412
G +L P Q L I GEY C N G+ S + + V
Sbjct: 2571 GGSL-----PSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHV 2625
Query: 413 LLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLI 472
+PP IE + G+ L + C P +++W K G L + Q S L
Sbjct: 2626 PSVSPPIRIESSSPTVVE--GQTLDLNCVVARQPQAIITWYKRGGSLPSRHQT-HGSHLR 2682
Query: 473 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSP 508
L ++ G + C A+N + + S V+ SP
Sbjct: 2683 LHQMSVADSGEYVCRANNNIDALEAS---IVISVSP 2715
Score = 47.4 bits (111), Expect = 8e-05
Identities = 28/83 (33%), Positives = 39/83 (46%), Gaps = 5/83 (6%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQN----GT 190
PPQ P ++ + VT CVA G P P + W+L + +V V + GT
Sbjct: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHI-PSHPRVTVTSEGGRGT 463
Query: 191 LRIRRVERGSSGVYTCQASSTEG 213
L IR V+ G YTC+A + G
Sbjct: 464 LIIRDVKESDQGAYTCEAMNARG 486
Score = 46.6 bits (109), Expect = 1e-04
Identities = 59/231 (25%), Positives = 89/231 (38%), Gaps = 18/231 (7%)
Query: 284 GSLRLLATQPDDAG--CYTCVPSNGLLHPPSASAYL----TVLYPAQVTAMPPETPLPIG 337
G R A +P G C C P G + PS T P V P + +P G
Sbjct: 1634 GGYRCTACEPGYTGQYCEQCGP--GYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQG 1691
Query: 338 MPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCT 396
+RC V +PP F +DG+ + G Q +GS L G Y CT
Sbjct: 1692 GSHSLRCQVSGSPPHYFYWSREDGRPVP----SGTQQRHQGSELHFPSVQPSDAGVYICT 1747
Query: 397 PYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQE---VGRELLIPCSAQGDPPP-VVSW 452
N L + S ++ +AP I EE + G ++ C+A+ P + W
Sbjct: 1748 CRN-LHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVW 1806
Query: 453 TKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYV 503
T++ G +D N L +R + G + C+ SN A + ++V
Sbjct: 1807 TRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHV 1857
Score = 37.0 bits (84), Expect = 0.11
Identities = 21/80 (26%), Positives = 35/80 (43%), Gaps = 5/80 (6%)
Query: 417 PPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNS-----SL 471
PP + P+E G+ + C A G P P+++W + +V S +L
Sbjct: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
Query: 472 ILRPLTKEAHGHWECSASNA 491
I+R + + G + C A NA
Sbjct: 465 IIRDVKESDQGAYTCEAMNA 484
Score = 31.6 bits (70), Expect = 4.7
Identities = 52/239 (21%), Positives = 87/239 (36%), Gaps = 34/239 (14%)
Query: 804 LKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEP---ICRGPDGRFVMGPTVA 860
L ++ + +P ++ + P T +P P P S PLP P CR +G + +
Sbjct: 247 LLVETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACR--NGHCIPRDYLC 304
Query: 861 APQE--RSGREQAEPRTPAQRLARSFDCSSSSPS----GAPQPLCIEDISPVAPPPAAPP 914
QE G ++ + P F C + + ED + A P P
Sbjct: 305 DGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRP 364
Query: 915 SPLPGPGP---LLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPE 971
+ GP + + +P + + D P + PP +
Sbjct: 365 EEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVV--------------- 409
Query: 972 TPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSSGRGS 1030
TPP ++ G V A T + +W RL G +P+ PR ++TS+ GRG+
Sbjct: 410 TPPRESIQASRGQTVTFTCVAIGVPTPIINW----RLNWGHIPSHPRVTVTSE-GGRGT 463
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 115 bits (287), Expect = 3e-25
Identities = 103/367 (28%), Positives = 150/367 (40%), Gaps = 25/367 (6%)
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTW--KLRGKDLGQGQGQVQVQNGTLRIRRVERGS 200
P +EV V C A G+P P + W DL +GTL IR
Sbjct: 240 PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESD 299
Query: 201 SGVYTCQASSTEGSATHATQLL----VLGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN 256
GVY C A ++ G A + +L + P V+ P+++ V +L C A +P
Sbjct: 300 QGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHP 359
Query: 257 LTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAY 316
L +W +DN SR + L L D G +TC +N A+A
Sbjct: 360 LI-TWTRDNGLELDGSR-----HVATSSGLYLQNITQRDHGRFTCHANNSH-GTVQAAAN 412
Query: 317 LTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGT 376
+ V P Q T P + + C NPP + V WTK G L ++ Q T
Sbjct: 413 IIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIV-WTKTGGQLPVE-----GQHT 466
Query: 377 ---EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG 433
G+L I + G+Y C +SLG S V KA F + P++ EVG
Sbjct: 467 VLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSV-EVG 525
Query: 434 RELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPLTKEAHGHWECSASNA 491
+ + I C AQG+P P+++W K G + G+ VD +L + G +EC A N+
Sbjct: 526 KNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
Query: 492 VARVATS 498
T+
Sbjct: 586 FGLAVTN 592
Score = 87.8 bits (216), Expect = 5e-17
Identities = 84/324 (25%), Positives = 135/324 (41%), Gaps = 18/324 (5%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
R+ + +L I R DQG Y+C E + + ++ + P F P
Sbjct: 281 RLNVFDDGTLMIRNTRESDQGVYQC---MARNSAGEAKTQSAMLRYSSLPAKPSF-VIQP 336
Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTW-KLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202
EV TL C+A G P P +TW + G +L G V +G L ++ + + G
Sbjct: 337 QDTEVLIGTSTTLECMATGHPHPLITWTRDNGLEL-DGSRHVATSSG-LYLQNITQRDHG 394
Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWF 262
+TC A+++ G+ A ++V PP V PK+ V V C A+ P + W
Sbjct: 395 RFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIV-WT 453
Query: 263 QDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYP 322
+ + ++ + +L G+LR+ D G Y C + L S LTV
Sbjct: 454 KTGGQL----PVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSS-LGVKKVSVQLTVKPK 508
Query: 323 AQV--TAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 380
A T +P +T + +G I C + P + ++W K+G +Q+ + + EG+L
Sbjct: 509 ALAVFTQLPQDTSVEVGKNINISCHAQGEPQPI-ITWNKEG--VQITESGKFHVDDEGTL 565
Query: 381 IIALGNEDALGEYSCTPYNSLGTA 404
I G Y C NS G A
Sbjct: 566 TIYDAGFPDQGRYECVARNSFGLA 589
Score = 82.4 bits (202), Expect = 2e-15
Identities = 77/293 (26%), Positives = 120/293 (40%), Gaps = 13/293 (4%)
Query: 324 QVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIA 383
++T P + +P G C NP + W + +L L+ + +G+L+I
Sbjct: 235 RITFEPQDVEVPSGNTVYFTCRAEGNPKPEII-WIHNNHSLDLEDDTRLNVFDDGTLMIR 293
Query: 384 LGNEDALGEYSCTPYNSLGTAGP-SPVTRVL-LKAPPAFIERPKEEYFQEVGRELLIPCS 441
E G Y C NS G A S + R L A P+F+ +P++ +G + C
Sbjct: 294 NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVL-IGTSTTLECM 352
Query: 442 AQGDPPPVVSWTKV-GRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTN 500
A G P P+++WT+ G L G V ++S L L+ +T+ HG + C A+N+ V + N
Sbjct: 353 ATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAAN 412
Query: 501 VYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSL 560
+ V VT V L + A V W DG VW + P H +S
Sbjct: 413 IIVQAPPQFTVTPKDQVVLEEHA-VEWLCEADGN-PPPVIVWTKTGGQLPVEGQHTVLS- 469
Query: 561 AVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAP 613
+ L + H Q Q+ A + LG S + P+ L P
Sbjct: 470 -----SGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLP 517
Score = 75.1 bits (183), Expect = 4e-13
Identities = 55/225 (24%), Positives = 98/225 (43%), Gaps = 15/225 (6%)
Query: 83 GRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETP 142
G + + L ++ + D G + C H + ++ V +PPQF TP
Sbjct: 373 GSRHVATSSGLYLQNITQRDHGRFTC-------HANNSHGTVQAAANIIVQAPPQFTVTP 425
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202
+ ++E V C A G+P P + W G L + +GTLRI R + G
Sbjct: 426 KDQVVLEE-HAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQG 484
Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVP--PKNSTVNASQDVSLACHAEAYPANLTYS 260
Y CQA S+ G + QL V + V P++++V ++++++CHA+ P + +
Sbjct: 485 QYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPI-IT 543
Query: 261 WFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN 305
W ++ + + + + +G+L + D G Y CV N
Sbjct: 544 WNKEGVQITESGKF----HVDDEGTLTIYDAGFPDQGRYECVARN 584
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,024,810
Number of Sequences: 37866
Number of extensions: 3809155
Number of successful extensions: 35712
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 246
Number of HSP's successfully gapped in prelim test: 1253
Number of HSP's that attempted gapping in prelim test: 20265
Number of HSP's gapped (non-prelim): 11149
length of query: 1179
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1066
effective length of database: 13,968,660
effective search space: 14890591560
effective search space used: 14890591560
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.