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Search of human proteins with 20149304
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20149304 ISY1 splicing factor homolog [Homo sapiens]
(285 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20149304 ISY1 splicing factor homolog [Homo sapiens] 568 e-162
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 51 1e-06
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 46 3e-05
gi|221219020 NYD-SP11 protein [Homo sapiens] 45 7e-05
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 44 1e-04
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 44 1e-04
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 44 1e-04
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 44 1e-04
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 44 1e-04
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 44 1e-04
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 44 1e-04
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 44 1e-04
gi|21735569 claspin [Homo sapiens] 43 3e-04
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 43 3e-04
gi|40254947 thioredoxin-related transmembrane protein 4 [Homo sa... 43 4e-04
gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ... 42 5e-04
gi|55750053 atrophin-1 [Homo sapiens] 42 6e-04
gi|55750041 atrophin-1 [Homo sapiens] 42 6e-04
gi|209862789 microtubule associated monoxygenase, calponin and L... 42 6e-04
gi|22758136 MAP7 domain containing 2 [Homo sapiens] 42 8e-04
gi|148746195 trichohyalin [Homo sapiens] 41 0.001
gi|92859701 myosin VI [Homo sapiens] 41 0.001
gi|33356174 pinin, desmosome associated protein [Homo sapiens] 41 0.001
gi|34878777 ring finger protein 20 [Homo sapiens] 40 0.002
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 40 0.002
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 40 0.002
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 40 0.002
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 40 0.002
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 40 0.002
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 40 0.002
>gi|20149304 ISY1 splicing factor homolog [Homo sapiens]
Length = 285
Score = 568 bits (1465), Expect = e-162
Identities = 285/285 (100%), Positives = 285/285 (100%)
Query: 1 MARNAEKAMTALARFRQAQLEEGKVKERRPFLASECTELPKAEKWRRQIIGEISKKVAQI 60
MARNAEKAMTALARFRQAQLEEGKVKERRPFLASECTELPKAEKWRRQIIGEISKKVAQI
Sbjct: 1 MARNAEKAMTALARFRQAQLEEGKVKERRPFLASECTELPKAEKWRRQIIGEISKKVAQI 60
Query: 61 QNAGLGEFRIRDLNDEINKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGY 120
QNAGLGEFRIRDLNDEINKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGY
Sbjct: 61 QNAGLGEFRIRDLNDEINKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGY 120
Query: 121 KYFGAAKDLPGVRELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKK 180
KYFGAAKDLPGVRELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKK
Sbjct: 121 KYFGAAKDLPGVRELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKK 180
Query: 181 LRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFI 240
LRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFI
Sbjct: 181 LRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFI 240
Query: 241 AHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARRLLGY 285
AHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARRLLGY
Sbjct: 241 AHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARRLLGY 285
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 50.8 bits (120), Expect = 1e-06
Identities = 57/208 (27%), Positives = 93/208 (44%), Gaps = 21/208 (10%)
Query: 42 AEKWR--RQIIGEISKKVAQIQNAGLGEFRIRDLND-------EINKLLREKGHWEVRIK 92
AE W+ + GE K +++ G GE + + + E + RE+GH + R +
Sbjct: 666 AEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQ 725
Query: 93 EL---GGPDYGKVGPKMLDHEGKEVPGNRGYKYFGAAKDLPGVRELFEKEPLPPPRKTRA 149
E+ G ++G+ + D E +E G K G +++ G RE E E R +
Sbjct: 726 EMEEGGEEEHGEGEEEEGDREEEEEKEGEG-KEEGEGEEVEGEREKEEGERKKEERAGKE 784
Query: 150 ELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEE 209
E + + G +E +G E+E ++ VE+ K ERE GE EEEE E
Sbjct: 785 EKGEEEGDQGEGEEEETEGR--GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEG 842
Query: 210 EEINIYAVTEEESDEEGSQEKGGDDSQQ 237
EE E E +EE + KG ++ ++
Sbjct: 843 EE------EEGEGEEEEGEGKGEEEGEE 864
Score = 34.7 bits (78), Expect = 0.098
Identities = 53/238 (22%), Positives = 98/238 (41%), Gaps = 29/238 (12%)
Query: 23 GKVKERRPFLASECTELPKAEKWRRQIIGEISKKVAQIQNAGLGEFRIRDLNDEINKLLR 82
G KE+ L+ + T+ + + + + +GE A+ G G+ + +
Sbjct: 617 GGRKEKTEILSDDLTDKAEVSEGKAKSVGE-----AEDGPEGRGDGTCEEGSSGAE---- 667
Query: 83 EKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGYKYFGAAKDLPGVRELFEKEPLP 142
HW+ +E G D G+ + KE+ +K E +KE
Sbjct: 668 ---HWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDG-------EEQEQKEREQ 717
Query: 143 PPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKLRAELV---EKWKAEREARLAR 199
+K R + M+ E +G +E++G E+E EK+ + E+ + ERE
Sbjct: 718 GHQKERNQEMEEGGEEEHGEGEEEEG---DREEEEEKEGEGKEEGEGEEVEGEREKEEGE 774
Query: 200 GEKEE----EEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEE 253
+KEE EE+ EEE + EEE++ G +++ G + + + ++E EE
Sbjct: 775 RKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEE 832
Score = 33.5 bits (75), Expect = 0.22
Identities = 18/51 (35%), Positives = 28/51 (54%), Gaps = 2/51 (3%)
Query: 188 KWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQK 238
+W+ E E GE EEE E E E EEE + EG +E+G ++ +++
Sbjct: 954 EWEGEEEE--GEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEE 1002
Score = 33.5 bits (75), Expect = 0.22
Identities = 24/68 (35%), Positives = 37/68 (54%), Gaps = 5/68 (7%)
Query: 174 EQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEE---EINIYAVTEEESDEEGSQEK 230
E+E E ++ E VE + E E GE+E EE E+E E N EEE +EEG ++
Sbjct: 1014 EEEEEGEVEGE-VEGEEGEGEGEEEEGEEEGEEREKEGEGEEN-RRNREEEEEEEGKYQE 1071
Query: 231 GGDDSQQK 238
G++ ++
Sbjct: 1072 TGEEENER 1079
Score = 32.3 bits (72), Expect = 0.49
Identities = 39/130 (30%), Positives = 56/130 (43%), Gaps = 16/130 (12%)
Query: 110 EGKEVPGNRGYKYFGAAKDLPGVRELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGV 169
EG EV G G ++ G RE E+E + E + E G +E +G
Sbjct: 810 EGGEVEG-------GEVEEGKGEREEEEEEGEGEEEEGEGE-----EEEGEGEEEEGEG- 856
Query: 170 IVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEE-EEINIYAVTEEESDEEGSQ 228
E+E E+ E E+ + E E GE EEE E E EE EEE + EG +
Sbjct: 857 --KGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEE 914
Query: 229 EKGGDDSQQK 238
E+G +++
Sbjct: 915 EEGEGKGEEE 924
Score = 32.0 bits (71), Expect = 0.64
Identities = 34/118 (28%), Positives = 53/118 (44%), Gaps = 9/118 (7%)
Query: 164 DEDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESD 223
+E++G E+E E E E+ + E E GE+EE E E EE EEE +
Sbjct: 949 EEEEGEWEGEEEEGE----GEGEEEGEGEGEEGEGEGEEEEGEGEGEEEE----GEEEGE 1000
Query: 224 EEGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARR 281
EEG E+ G+ ++ V + E EE ++ E ++ + + EE RR
Sbjct: 1001 EEGEGEEEGEGEGEE-EEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRR 1057
Score = 31.2 bits (69), Expect = 1.1
Identities = 19/50 (38%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Query: 190 KAEREARLARGEKEEEE-EEEEEINIYAVTEEESDEEGSQEKGGDDSQQK 238
K E E GE EEEE E E E EEE + EG +E+G + +++
Sbjct: 920 KGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEE 969
Score = 30.8 bits (68), Expect = 1.4
Identities = 42/152 (27%), Positives = 61/152 (40%), Gaps = 23/152 (15%)
Query: 83 EKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGYKYFGAAKDLPGVRELFEKEPLP 142
E+G WE +E G EG+E G + G ++ G E E+E
Sbjct: 951 EEGEWEGEEEEGEG-------------EGEEEGEGEGEEGEGEGEEEEGEGEGEEEEG-- 995
Query: 143 PPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEK 202
+ E + E G +E++ V E E E+ E+ + E E R GE
Sbjct: 996 ---EEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEG 1052
Query: 203 EE-----EEEEEEEINIYAVTEEESDEEGSQE 229
EE EEEEEEE EEE++ + +E
Sbjct: 1053 EENRRNREEEEEEEGKYQETGEEENERQDGEE 1084
Score = 29.3 bits (64), Expect = 4.1
Identities = 25/73 (34%), Positives = 35/73 (47%), Gaps = 2/73 (2%)
Query: 165 EDDGVIVPLEQEYEKKLRAELVE-KWKAEREARLARGEKEEEEEEEEEINIYAVTEEESD 223
E++G E+E E K E E + + E E GE E E EEEE + EEE +
Sbjct: 905 EEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEE-GEWEGEEEEGE 963
Query: 224 EEGSQEKGGDDSQ 236
EG +E G+ +
Sbjct: 964 GEGEEEGEGEGEE 976
Score = 29.3 bits (64), Expect = 4.1
Identities = 17/51 (33%), Positives = 26/51 (50%)
Query: 187 EKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQ 237
E+ + E E GE+EE E E EE EEE + EG + +G + ++
Sbjct: 935 EEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEE 985
Score = 28.1 bits (61), Expect = 9.2
Identities = 17/52 (32%), Positives = 25/52 (48%)
Query: 187 EKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQK 238
E+ + E E GE EEEE E E E E + EG E+G + +++
Sbjct: 933 EEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEE 984
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 46.2 bits (108), Expect = 3e-05
Identities = 52/198 (26%), Positives = 87/198 (43%), Gaps = 39/198 (19%)
Query: 105 KMLDHEGKEVPGNRGYKYFGAAKDLPGVRELFE---KEPLPPPRKTRA-----ELMKAID 156
K+L +G EVP LP R ++E ++ +P +++ EL A++
Sbjct: 424 KLLQAQGVEVPSK---------DSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVE 474
Query: 157 FEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKA---EREARLARGEK---------EE 204
G + E + P+E E E+ ++ W+A + E G K EE
Sbjct: 475 VMEQG-VPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEE 533
Query: 205 EEEEEEEINIYAVTEEESDEEGSQE-KGGDDSQQKFIAHVPVPSQQEIEEALVRR--KKM 261
EEEEEEE +EEE +EEG E GD+ +K V +++ + L ++ K+M
Sbjct: 534 EEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEK------VSDEKDSGKTLDKKPSKEM 587
Query: 262 ELLQKYASETLQAQSEEA 279
+Y S+ + + E A
Sbjct: 588 SSDSEYDSDDDRTKEERA 605
Score = 35.4 bits (80), Expect = 0.058
Identities = 37/161 (22%), Positives = 78/161 (48%), Gaps = 18/161 (11%)
Query: 132 VRELFEKEPLPPPRKTRA---ELMKAIDFEYY-GYLDEDDGVIVPLEQEYEKKLRAELVE 187
+R+L EKE L +K ++ E + + E + D GVI E++ E AE
Sbjct: 250 LRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDN 309
Query: 188 KW-KAEREARLARGEKEEEEEEEE----EINIYAVTEEESDEEGSQEKGGDDSQQKFIAH 242
+ K +++ + +GEKEE+E+E++ + + A+ E + + +E+ + +++
Sbjct: 310 EGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERI--- 366
Query: 243 VPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARRLL 283
+ +EE +RK+ E L++ E + + +E + L
Sbjct: 367 ------KRLEELEAKRKEEERLEQEKRERKKQKEKERKERL 401
Score = 30.0 bits (66), Expect = 2.4
Identities = 31/110 (28%), Positives = 52/110 (47%), Gaps = 10/110 (9%)
Query: 174 EQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGD 233
E+E EKK + KA +EA E+EE ++ EEE I + E E+ + + +
Sbjct: 327 EKEKEKK-KGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQE 385
Query: 234 DSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARRLL 283
++K Q+E E +K+ +LL K E +A++E +LL
Sbjct: 386 KRERK--------KQKEKERKERLKKEGKLLTKSQREA-RARAEATLKLL 426
Score = 29.3 bits (64), Expect = 4.1
Identities = 20/72 (27%), Positives = 36/72 (50%), Gaps = 11/72 (15%)
Query: 188 KWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFIAHVPVPS 247
K K + + + E+E ++ +EE+ + + E+E E G + D S+QK S
Sbjct: 224 KIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKK----DQSKQK-------ES 272
Query: 248 QQEIEEALVRRK 259
Q++ EE V+ K
Sbjct: 273 QRKFEEETVKSK 284
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 45.1 bits (105), Expect = 7e-05
Identities = 56/263 (21%), Positives = 112/263 (42%), Gaps = 44/263 (16%)
Query: 16 RQAQLEEGKVKERRPFLASECTELPKAEKWRRQIIGEISKKVAQIQNAGLGEFRIRDLND 75
R+ +E+ K+ + + + +EL K EK + +++ K+ ++ N + + +
Sbjct: 2109 RRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMIN------KEEKMTE 2162
Query: 76 EINKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGYKYFGAAKDLPGVREL 135
E +KL R+ + +E GG + +V P + K RG K
Sbjct: 2163 EESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDK-------------- 2208
Query: 136 FEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREA 195
P K +++ + E++ +E + ++ LE++ E + + ERE
Sbjct: 2209 -------PKEKFSSQVDEVESEEHFS--EEMESLLDELEKQESLSSEEEEEREEEEEREE 2259
Query: 196 RLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEEAL 255
R E+EE +EEEE EEE ++ +EK ++ Q+K +E+ E
Sbjct: 2260 EEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEK----------EEVFE-- 2307
Query: 256 VRRKKMELLQKYASETLQAQSEE 278
+K E++ + +E+L + EE
Sbjct: 2308 ---EKEEIMSEEETESLSDEEEE 2327
Score = 40.8 bits (94), Expect = 0.001
Identities = 30/103 (29%), Positives = 52/103 (50%), Gaps = 14/103 (13%)
Query: 178 EKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQ 237
+KKL+ E +WK E L+ KE++ ++EEE+ + EEE EG +++ +Q
Sbjct: 1513 DKKLKWE---EWKQVWENMLSSKSKEQQYKDEEEVTL----EEEVSREGEEKEQQVTEEQ 1565
Query: 238 KFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEAR 280
+ I Q+E + A + RK+ +K A E + EE +
Sbjct: 1566 RHI-------QEEHKWARIHRKRARAEKKRAQEERKLAQEEEK 1601
Score = 33.1 bits (74), Expect = 0.29
Identities = 25/84 (29%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
Query: 178 EKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQ 237
EKK E E+ A+ E +LA+ E++ +EE + Y V + D E +Q +G ++
Sbjct: 1585 EKKRAQE--ERKLAQEEEKLAQEERQLAQEERKLAQAY-VKITQDDREMAQAEGKFAQKE 1641
Query: 238 KFIAHVPVPSQQEIEEALVRRKKM 261
+ +A QE E+ +RKK+
Sbjct: 1642 ETLAQRGEKLSQEAEKLAQKRKKL 1665
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 44.3 bits (103), Expect = 1e-04
Identities = 34/122 (27%), Positives = 56/122 (45%), Gaps = 2/122 (1%)
Query: 165 EDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDE 224
E+ ++ L+ + + + E AE + E+EEEEEEEE EEE +E
Sbjct: 246 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE 305
Query: 225 EGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYAS--ETLQAQSEEARRL 282
E +E+ G +S++ S++E+ E R + LL S + +SEEA
Sbjct: 306 EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 365
Query: 283 LG 284
+G
Sbjct: 366 VG 367
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 44.3 bits (103), Expect = 1e-04
Identities = 34/122 (27%), Positives = 56/122 (45%), Gaps = 2/122 (1%)
Query: 165 EDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDE 224
E+ ++ L+ + + + E AE + E+EEEEEEEE EEE +E
Sbjct: 256 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE 315
Query: 225 EGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYAS--ETLQAQSEEARRL 282
E +E+ G +S++ S++E+ E R + LL S + +SEEA
Sbjct: 316 EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 375
Query: 283 LG 284
+G
Sbjct: 376 VG 377
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 44.3 bits (103), Expect = 1e-04
Identities = 34/122 (27%), Positives = 56/122 (45%), Gaps = 2/122 (1%)
Query: 165 EDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDE 224
E+ ++ L+ + + + E AE + E+EEEEEEEE EEE +E
Sbjct: 247 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE 306
Query: 225 EGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYAS--ETLQAQSEEARRL 282
E +E+ G +S++ S++E+ E R + LL S + +SEEA
Sbjct: 307 EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 366
Query: 283 LG 284
+G
Sbjct: 367 VG 368
Score = 28.9 bits (63), Expect = 5.4
Identities = 25/120 (20%), Positives = 53/120 (44%), Gaps = 13/120 (10%)
Query: 164 DEDDGVIV--PLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEE 221
+EDD + + P + ++K+ EK K ++ AR+ EKE E E +
Sbjct: 78 EEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVK--EKEREHERR---------KRH 126
Query: 222 SDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARR 281
+E+ + + +++ +A +++ E L R+++ E + + + Q E RR
Sbjct: 127 REEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERR 186
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 44.3 bits (103), Expect = 1e-04
Identities = 34/122 (27%), Positives = 56/122 (45%), Gaps = 2/122 (1%)
Query: 165 EDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDE 224
E+ ++ L+ + + + E AE + E+EEEEEEEE EEE +E
Sbjct: 256 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE 315
Query: 225 EGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYAS--ETLQAQSEEARRL 282
E +E+ G +S++ S++E+ E R + LL S + +SEEA
Sbjct: 316 EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 375
Query: 283 LG 284
+G
Sbjct: 376 VG 377
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 44.3 bits (103), Expect = 1e-04
Identities = 34/122 (27%), Positives = 56/122 (45%), Gaps = 2/122 (1%)
Query: 165 EDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDE 224
E+ ++ L+ + + + E AE + E+EEEEEEEE EEE +E
Sbjct: 224 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE 283
Query: 225 EGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYAS--ETLQAQSEEARRL 282
E +E+ G +S++ S++E+ E R + LL S + +SEEA
Sbjct: 284 EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 343
Query: 283 LG 284
+G
Sbjct: 344 VG 345
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 44.3 bits (103), Expect = 1e-04
Identities = 34/122 (27%), Positives = 56/122 (45%), Gaps = 2/122 (1%)
Query: 165 EDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDE 224
E+ ++ L+ + + + E AE + E+EEEEEEEE EEE +E
Sbjct: 213 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE 272
Query: 225 EGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYAS--ETLQAQSEEARRL 282
E +E+ G +S++ S++E+ E R + LL S + +SEEA
Sbjct: 273 EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 332
Query: 283 LG 284
+G
Sbjct: 333 VG 334
Score = 28.9 bits (63), Expect = 5.4
Identities = 25/120 (20%), Positives = 53/120 (44%), Gaps = 13/120 (10%)
Query: 164 DEDDGVIV--PLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEE 221
+EDD + + P + ++K+ EK K ++ AR+ EKE E E +
Sbjct: 44 EEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVK--EKEREHERR---------KRH 92
Query: 222 SDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARR 281
+E+ + + +++ +A +++ E L R+++ E + + + Q E RR
Sbjct: 93 REEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERR 152
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 44.3 bits (103), Expect = 1e-04
Identities = 34/122 (27%), Positives = 56/122 (45%), Gaps = 2/122 (1%)
Query: 165 EDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDE 224
E+ ++ L+ + + + E AE + E+EEEEEEEE EEE +E
Sbjct: 2 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE 61
Query: 225 EGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYAS--ETLQAQSEEARRL 282
E +E+ G +S++ S++E+ E R + LL S + +SEEA
Sbjct: 62 EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 121
Query: 283 LG 284
+G
Sbjct: 122 VG 123
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 44.3 bits (103), Expect = 1e-04
Identities = 34/122 (27%), Positives = 56/122 (45%), Gaps = 2/122 (1%)
Query: 165 EDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDE 224
E+ ++ L+ + + + E AE + E+EEEEEEEE EEE +E
Sbjct: 258 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE 317
Query: 225 EGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYAS--ETLQAQSEEARRL 282
E +E+ G +S++ S++E+ E R + LL S + +SEEA
Sbjct: 318 EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 377
Query: 283 LG 284
+G
Sbjct: 378 VG 379
>gi|21735569 claspin [Homo sapiens]
Length = 1339
Score = 43.1 bits (100), Expect = 3e-04
Identities = 38/128 (29%), Positives = 57/128 (44%), Gaps = 28/128 (21%)
Query: 102 VGPKMLDHEGKEVPGNRGYKYFGAAKDLPGVRELFEKEPLPPPRKTRAELMKAIDFEYYG 161
+ PK LD PG + ++ +R E R+ R L K
Sbjct: 577 LAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEE-------RQKRQALFK-------- 621
Query: 162 YLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEE 221
LD +DG E E++ E+ ++ + + E ++ + EKEEE EEEEE EEE
Sbjct: 622 -LDNEDGF------EEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEE------KEEE 668
Query: 222 SDEEGSQE 229
+EEG+QE
Sbjct: 669 EEEEGNQE 676
Score = 30.0 bits (66), Expect = 2.4
Identities = 13/76 (17%), Positives = 35/76 (46%)
Query: 203 EEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKME 262
+EEE+EEEE + + +++ + +++ D + ++E+ + + K+
Sbjct: 989 KEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQM 1048
Query: 263 LLQKYASETLQAQSEE 278
L+KY + + +
Sbjct: 1049 RLRKYLEDEAEVSGSD 1064
Score = 29.6 bits (65), Expect = 3.2
Identities = 21/76 (27%), Positives = 41/76 (53%), Gaps = 11/76 (14%)
Query: 203 EEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKME 262
EEEEEEEEE+ +ES+E+G ++ ++ +++ ++E EE ++ E
Sbjct: 629 EEEEEEEEEMT------DESEEDGEEKVEKEEKEEELEEE---EEKEEEEEEEGNQETAE 679
Query: 263 LLQKYASETLQAQSEE 278
L +SE ++ + E+
Sbjct: 680 FL--LSSEEIETKDEK 693
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 43.1 bits (100), Expect = 3e-04
Identities = 57/237 (24%), Positives = 102/237 (43%), Gaps = 27/237 (11%)
Query: 70 IRDLNDEINKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGYKYFGAAKDL 129
IRD +E ++ K H + K+ G D + + E +EVP G + ++
Sbjct: 289 IRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEP--SSIVNV 346
Query: 130 PG---VRELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKL----- 181
PG +R F + L K R+E ++ L E + L E +K++
Sbjct: 347 PGESTLRRDFLR--LQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKE 404
Query: 182 -RAELVEKWKAEREARLARGEKEEEEEEEEEINIYAV----TEEESDEEGSQEKGGDDSQ 236
R L E+ + EREAR + ++ E+EE+ + + EEE +EK + +
Sbjct: 405 QRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVERE 464
Query: 237 QKFI--------AHVPVPSQQEIEE--ALVRRKKMELLQKYASETLQAQSEEARRLL 283
Q++I H+ V QQ ++E L+ + E+ + +E LQ Q ++ + L
Sbjct: 465 QEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYL 521
>gi|40254947 thioredoxin-related transmembrane protein 4 [Homo
sapiens]
Length = 349
Score = 42.7 bits (99), Expect = 4e-04
Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 10/103 (9%)
Query: 174 EQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGD 233
E+E + E + + E + G+++E EEEEEE N+ A +EE E Q G+
Sbjct: 245 EEEKDDSNEEENKDSLVDDEEEKEDLGDEDEAEEEEEEDNLAAGVDEERSEANDQGPPGE 304
Query: 234 D----------SQQKFIAHVPVPSQQEIEEALVRRKKMELLQK 266
D ++ I+ P P+ E+ E +R++K + K
Sbjct: 305 DGVTREEVEPEEAEEGISEQPCPADTEVVEDSLRQRKSQHADK 347
>gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo
sapiens]
Length = 956
Score = 42.4 bits (98), Expect = 5e-04
Identities = 28/100 (28%), Positives = 54/100 (54%), Gaps = 5/100 (5%)
Query: 180 KLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQKF 239
KLRAE EK K + EA+ A+ E ++++EEE+E+ E+E E+ +++ +Q+
Sbjct: 349 KLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELK-----EKERREKREKDEKEKAEKQRL 403
Query: 240 IAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEA 279
Q+ +E L ++K E ++ E + ++E+A
Sbjct: 404 KEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKA 443
>gi|55750053 atrophin-1 [Homo sapiens]
Length = 1190
Score = 42.0 bits (97), Expect = 6e-04
Identities = 34/100 (34%), Positives = 44/100 (44%), Gaps = 14/100 (14%)
Query: 138 KEPLPPPRKTRAELMKAIDFEYYGYLDE-------DDGVIVPLEQEYEKKLRAELVEKWK 190
+ P PPP+ + + +LD D VPLE K RA+LVEK +
Sbjct: 745 RSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVR 804
Query: 191 AEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEK 230
E E R AR EKE E E E E E E ++E E+
Sbjct: 805 REAEQR-AREEKERERERERE------KEREREKERELER 837
>gi|55750041 atrophin-1 [Homo sapiens]
Length = 1190
Score = 42.0 bits (97), Expect = 6e-04
Identities = 34/100 (34%), Positives = 44/100 (44%), Gaps = 14/100 (14%)
Query: 138 KEPLPPPRKTRAELMKAIDFEYYGYLDE-------DDGVIVPLEQEYEKKLRAELVEKWK 190
+ P PPP+ + + +LD D VPLE K RA+LVEK +
Sbjct: 745 RSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVR 804
Query: 191 AEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEK 230
E E R AR EKE E E E E E E ++E E+
Sbjct: 805 REAEQR-AREEKERERERERE------KEREREKERELER 837
>gi|209862789 microtubule associated monoxygenase, calponin and LIM
domain containing 3 isoform 1 [Homo sapiens]
Length = 2002
Score = 42.0 bits (97), Expect = 6e-04
Identities = 29/98 (29%), Positives = 47/98 (47%), Gaps = 3/98 (3%)
Query: 177 YEKKLRAELVEKWKAEREARLARG---EKEEEEEEEEEINIYAVTEEESDEEGSQEKGGD 233
+++ +R + K K+E E ++ EEEEEEEEE + + +EE S E G
Sbjct: 963 WKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAGNQ 1022
Query: 234 DSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASET 271
QQ A P+ Q ++ +R ++ E ASE+
Sbjct: 1023 RLQQVMHAADPLEIQADVHWTHIREREEEERMAPASES 1060
>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
Length = 732
Score = 41.6 bits (96), Expect = 8e-04
Identities = 33/115 (28%), Positives = 58/115 (50%), Gaps = 8/115 (6%)
Query: 173 LEQEYEKKLRAELVEKWKAEREARLARGEKE-----EEEEEEEEINIYAVTEEESDEEGS 227
L++E E++ R E E+ + ERE + E+E EE ++EE E++ E
Sbjct: 413 LQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEE 472
Query: 228 QEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARRL 282
+ K G+++++K + + +QE E+ + K M QK A+ET + E RL
Sbjct: 473 KRKAGEEAKRKAEEELLLKEKQEQEK---QEKAMIEKQKEAAETKAREVAEQMRL 524
Score = 32.7 bits (73), Expect = 0.37
Identities = 29/101 (28%), Positives = 51/101 (50%), Gaps = 12/101 (11%)
Query: 174 EQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDE--------E 225
+QE E+K + E EK K E E + GE E + + EEE+ + E+E E E
Sbjct: 453 KQEEERKRQEE--EKKKQEGEEKRKAGE-EAKRKAEEELLLKEKQEQEKQEKAMIEKQKE 509
Query: 226 GSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQK 266
++ K + ++Q + + Q E +E L R+K+++ + K
Sbjct: 510 AAETKAREVAEQMRLEREQIMLQIE-QERLERKKRIDEIMK 549
Score = 28.5 bits (62), Expect = 7.0
Identities = 21/103 (20%), Positives = 49/103 (47%), Gaps = 1/103 (0%)
Query: 167 DGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINI-YAVTEEESDEE 225
+G + E++ K R E EK A RE ++ +K + E+++ + EE+ E
Sbjct: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
Query: 226 GSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYA 268
+ ++ +++ + + + +L R +++EL +KY+
Sbjct: 106 DQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYS 148
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 40.8 bits (94), Expect = 0.001
Identities = 33/106 (31%), Positives = 54/106 (50%), Gaps = 10/106 (9%)
Query: 173 LEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGG 232
L+QE E+ LR E ++ + ERE R R E+E ++EEE+ + EE ++ QE
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERE-RQCREEEELQQEEEQ------LLREEREKRRRQEL-- 1136
Query: 233 DDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEE 278
+ Q + V +Q + E +R++ EL ++Y E Q EE
Sbjct: 1137 -ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEE 1181
Score = 38.9 bits (89), Expect = 0.005
Identities = 31/110 (28%), Positives = 55/110 (50%), Gaps = 12/110 (10%)
Query: 174 EQEYEKKLRAELVEKWKAE--REARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKG 231
E+ E++L+ E VE+ + E RE RL R E EEE ++ + + E EE Q++
Sbjct: 595 EERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ-------LLKSEEQEERRQQQL 647
Query: 232 GDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARR 281
+ Q++ + ++E EE L +R K E ++ + L + +E R
Sbjct: 648 RREQQERREQRL---KREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694
Score = 38.5 bits (88), Expect = 0.007
Identities = 30/108 (27%), Positives = 53/108 (49%), Gaps = 5/108 (4%)
Query: 175 QEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDD 234
+E E++ + +L + + RE RL K EEEEE E + EEE E+ E+ +
Sbjct: 637 EEQEERRQQQLRREQQERREQRL----KREEEEERLEQRLKREHEEERREQELAEEEQEQ 692
Query: 235 SQQKFIAHVPVPSQQEIEEALVRRKKM-ELLQKYASETLQAQSEEARR 281
++++ + +P Q EA R+ K+ +K + + + EE RR
Sbjct: 693 ARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR 740
Score = 36.6 bits (83), Expect = 0.026
Identities = 30/109 (27%), Positives = 54/109 (49%), Gaps = 1/109 (0%)
Query: 173 LEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGG 232
L+QE E+ LR E ++ ERE R R E+E ++EEE+ + T + E K
Sbjct: 1026 LQQEEEQLLREEREKRRLQERE-RQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE 1084
Query: 233 DDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARR 281
+ Q++ P ++ +E + ++ E LQ+ + L+ + E+ RR
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR 1133
Score = 36.2 bits (82), Expect = 0.034
Identities = 62/282 (21%), Positives = 121/282 (42%), Gaps = 36/282 (12%)
Query: 6 EKAMTALARFRQAQLEEGKVKERRPFLASECTELPKAEKWRRQIIGEISK-------KVA 58
E+ + R +Q Q EE ++E + S+ E + +KWR Q+ E + K A
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQ--EQRRDQKWRWQLEEERKRRRHTLYAKPA 894
Query: 59 QIQNAGLGEFRIRDLNDEINKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGN- 117
+ + +++ +E+ + REK + + ++ + + + L E +E
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ 954
Query: 118 -RGYKYFGAAKDLPGVRELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQE 176
R +Y K +L +EP R+ R + Y +E++ L+QE
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK----------YREEEE-----LQQE 999
Query: 177 YEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQ 236
E+ LR E ++ + E E + + K+E ++EEE++ EE ++ QE+ + Q
Sbjct: 1000 EEQLLREEREKRRRQEWERQYRK--KDELQQEEEQL-----LREEREKRRLQER---ERQ 1049
Query: 237 QKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEE 278
+ + +Q + E R++ EL ++Y E Q EE
Sbjct: 1050 YREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEE 1091
Score = 35.8 bits (81), Expect = 0.044
Identities = 30/120 (25%), Positives = 58/120 (48%), Gaps = 18/120 (15%)
Query: 163 LDEDDGVIVPLE-QEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEE 221
L E++ + LE QE ++ + E ++ + RE +L R ++EE E++EE E+
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE------RREQ 324
Query: 222 SDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARR 281
+ QE+ + ++ Q+E E +RR++ E + + L+ + EE RR
Sbjct: 325 QERREQQEERREQQLRR--------EQEERREQQLRREQEE---ERREQQLRREQEEERR 373
Score = 35.0 bits (79), Expect = 0.075
Identities = 28/115 (24%), Positives = 57/115 (49%), Gaps = 5/115 (4%)
Query: 174 EQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEE---GSQEK 230
EQ++E++ R + +++ + ER L R E+ E E+E +EE E +E+
Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEE 494
Query: 231 GGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQK--YASETLQAQSEEARRLL 283
+ Q++ + ++ E+ L R+++ E LQ+ + + L+ + EE R L
Sbjct: 495 ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549
Score = 34.7 bits (78), Expect = 0.098
Identities = 26/127 (20%), Positives = 60/127 (47%), Gaps = 8/127 (6%)
Query: 164 DEDDGVIVPLEQEYEKKLRAELVEKWKAEREARLAR----GEKEEEEEEEEEINIYAVTE 219
+E+DG+ E+ ++ R + +W+ E E + R + +E+ +E + E
Sbjct: 851 EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE 910
Query: 220 EESDEEGSQEKGGDDSQQKFIAHVPVPSQQE--IEEALVRRKKMELLQKYASETLQAQSE 277
EE E +++ + ++++ + ++E + E +R++ E ++Y + Q E
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKE 970
Query: 278 EARRLLG 284
E +LLG
Sbjct: 971 E--QLLG 975
Score = 33.9 bits (76), Expect = 0.17
Identities = 28/107 (26%), Positives = 52/107 (48%), Gaps = 10/107 (9%)
Query: 174 EQEYEKKLRAELVEKWKAEREARLARGEKEEEE--EEEEEINIYAVTEEESDEEGSQEKG 231
E+E +++ L E+ + R L R ++EEE +EEE++ EE ++ QE+
Sbjct: 1053 EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL-----LREEPEKRRRQER- 1106
Query: 232 GDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEE 278
+ Q + + +Q + E +R++ EL ++Y E Q EE
Sbjct: 1107 --ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEE 1151
Score = 33.1 bits (74), Expect = 0.29
Identities = 30/118 (25%), Positives = 57/118 (48%), Gaps = 11/118 (9%)
Query: 174 EQEYEKKLRAELVEKWKAEREARLARGEKE--------EEEEEEEEINIYAVTEEESDEE 225
EQ+ E++ + E E+ + RE +L R ++E E+EEE E + EEE E+
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 226 GSQEKGGDDSQQKFIAHVPVPSQQEI--EEALVRRKKMELLQKYASE-TLQAQSEEAR 280
+ + +Q+ + +Q++ E+ L R +++ Q+ E L+ + EE R
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433
Score = 32.7 bits (73), Expect = 0.37
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 5/123 (4%)
Query: 164 DEDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEE-- 221
+ED P +++ E++ +K + E+E LA GE++ E++E E +EE
Sbjct: 116 EEDQRRFEPRDRQLEEEPGQRRRQK-RQEQERELAEGEEQSEKQERLEQRDRQRRDEELW 174
Query: 222 SDEEGSQEKGGDDSQQKFIAHVPVPSQQEI--EEALVRRKKMELLQKYASETLQAQSEEA 279
+ QE+ ++++ + +E EE L RR+ +EL +K E Q + E
Sbjct: 175 RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234
Query: 280 RRL 282
R+
Sbjct: 235 DRV 237
Score = 32.7 bits (73), Expect = 0.37
Identities = 26/109 (23%), Positives = 52/109 (47%), Gaps = 7/109 (6%)
Query: 178 EKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQ 237
E+K+R + E+ E E +L R E +++ +E + + E+ E Q+ + +
Sbjct: 1585 EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK-FREDEQLLQEREEQQLHRQERDR 1643
Query: 238 KFIAHVPVPSQQEIEEALVR------RKKMELLQKYASETLQAQSEEAR 280
KF+ P +QE E+ L R++ +LLQ+ + L+ Q + +
Sbjct: 1644 KFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK 1692
Score = 32.3 bits (72), Expect = 0.49
Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 18/116 (15%)
Query: 174 EQEYEKKLRAE--LVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKG 231
E+ +++LR+E L + + RE L R E++ E+E E + EE D+ +E+
Sbjct: 525 EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREE- 583
Query: 232 GDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQ------SEEARR 281
+ QQ+ ++E EE L +R K E +++ E + Q EE RR
Sbjct: 584 -ERRQQRL--------KREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERR 630
Score = 32.3 bits (72), Expect = 0.49
Identities = 31/115 (26%), Positives = 55/115 (47%), Gaps = 9/115 (7%)
Query: 175 QEYEKKLRAELVEKWKAEREARLA----RGEKEEEE--EEEEEINIYAVTEEESDEEGSQ 228
QE ++K E + + ERE +L R +EEE+ +E EE + + E Q
Sbjct: 1639 QERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQ 1698
Query: 229 EKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARRLL 283
+ + ++KF+ +QE+E R++ +L Q+ E L+ Q E R++L
Sbjct: 1699 QLRRQERERKFLQEEQQLRRQELERKF--REEEQLRQETEQEQLRRQ-ERYRKIL 1750
Score = 32.0 bits (71), Expect = 0.64
Identities = 29/112 (25%), Positives = 54/112 (48%), Gaps = 13/112 (11%)
Query: 174 EQEYEKKLRAELVEKW-KAEREARLARGEKEEEE---EEEEEINIYAVTEEESDEEGSQE 229
+Q+ ++ E E+W K E E R + E+ E++ E+EE +EE EE Q+
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEE--EERLQQ 530
Query: 230 KGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARR 281
+ + Q + Q+E E L++R++ + L++ E + +E RR
Sbjct: 531 RLRSEQQLR-------REQEERREQLLKREEEKRLEQERREQRLKREQEERR 575
Score = 32.0 bits (71), Expect = 0.64
Identities = 26/108 (24%), Positives = 50/108 (46%), Gaps = 18/108 (16%)
Query: 174 EQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGD 233
+++ EK+ R E +W+ E R ++++EEE+ + EE E G
Sbjct: 733 QEQEEKRRRRESELQWQEEE-----RAHRQQQEEEQRRDFTWQWQAEEKSERG------- 780
Query: 234 DSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARR 281
+Q+ A P+ Q+E + R++ E Q++ E + + E+ RR
Sbjct: 781 --RQRLSARPPLREQRERQLRAEERQQRE--QRFLPE--EEEKEQRRR 822
Score = 31.6 bits (70), Expect = 0.83
Identities = 29/121 (23%), Positives = 54/121 (44%), Gaps = 17/121 (14%)
Query: 174 EQEYEKKLRAELVEKWKAEREARLARGEKEEE-------------EEEEEEINIYAVTEE 220
++ E++LR E E+ RE RL R E+EE E+EE + EE
Sbjct: 500 QERREQQLRREQEER----REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 221 ESDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEAR 280
+ E+ +E+ Q++ + ++ ++ L R ++ L Q+ E ++ +E R
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 281 R 281
R
Sbjct: 616 R 616
Score = 31.6 bits (70), Expect = 0.83
Identities = 37/138 (26%), Positives = 66/138 (47%), Gaps = 32/138 (23%)
Query: 172 PLEQEYEKKLRAE--------LVEKWKAEREARLARGEKEEE----EEEEEEINIYAVTE 219
PL ++ E++LRAE + + + + + R R E+E+E EEEE+ +
Sbjct: 789 PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848
Query: 220 EESDEEG---------SQEKGGD-------DSQQKFIAHVPVPSQQEIEEALVRRKKMEL 263
+ +E+G SQE+ D + ++K H + ++ ++E L RK+ +L
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT-LYAKPALQEQL--RKEQQL 905
Query: 264 LQKYASETLQAQSEEARR 281
LQ+ E LQ + E RR
Sbjct: 906 LQE-EEEELQREEREKRR 922
Score = 31.6 bits (70), Expect = 0.83
Identities = 28/117 (23%), Positives = 54/117 (46%), Gaps = 7/117 (5%)
Query: 172 PLEQEYEKKLRAELVEK-WKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEK 230
P E++ E++ + E + K++ E +L R E+EE+ +E + E+ E Q
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353
Query: 231 GGDDSQQKF----IAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARRLL 283
+ +KF + H + EE +RR++ E +K+ E Q + +E + L
Sbjct: 1354 RRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERE--RKFLKEEQQLRCQEREQQL 1408
Score = 30.4 bits (67), Expect = 1.9
Identities = 18/67 (26%), Positives = 35/67 (52%), Gaps = 2/67 (2%)
Query: 173 LEQEYEKKLRAELVEKWKAEREARLARGE--KEEEEEEEEEINIYAVTEEESDEEGSQEK 230
L +E EK+ R EL +++ E E + + +EE+E+ +E EEE + +++
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213
Query: 231 GGDDSQQ 237
D+ Q+
Sbjct: 1214 YRDEDQR 1220
Score = 30.4 bits (67), Expect = 1.9
Identities = 33/150 (22%), Positives = 70/150 (46%), Gaps = 14/150 (9%)
Query: 137 EKEPLPPPRKTRAELMKAIDFEYYG--YLDEDDGVIVPLEQEYEKKLRAELVEKWKAERE 194
E++PL + R + + + G +L+E+ + QE E+K E + ERE
Sbjct: 1349 EEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL---RRQERERKFLKEEQQLRCQERE 1405
Query: 195 ARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEEA 254
+L + + EEE++++ + +EE Q+ + ++KF+ +Q++ +
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEE--QQVRRQERERKFL-----EEEQQLRQE 1458
Query: 255 LVR--RKKMELLQKYASETLQAQSEEARRL 282
R R++ +LLQ+ + L Q + + L
Sbjct: 1459 RHRKFREEEQLLQEREEQQLHRQERDRKFL 1488
Score = 29.6 bits (65), Expect = 3.2
Identities = 25/108 (23%), Positives = 50/108 (46%), Gaps = 15/108 (13%)
Query: 175 QEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDD 234
QE ++K R E + + ERE + +EE++ +E + E+ E Q+ +
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFL---EEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482
Query: 235 SQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEARRL 282
+KF+ EE +RR++ + +K+ + L++Q E + L
Sbjct: 1483 RDRKFLE----------EEQQLRRQERD--RKFREQELRSQEPERKFL 1518
Score = 28.9 bits (63), Expect = 5.4
Identities = 20/84 (23%), Positives = 38/84 (45%), Gaps = 18/84 (21%)
Query: 173 LEQEYEKKLRAELVEKWKAEREAR------------------LARGEKEEEEEEEEEINI 214
L +E EK+ R EL +++ E E + L R +EEEE ++EE +
Sbjct: 1124 LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL 1183
Query: 215 YAVTEEESDEEGSQEKGGDDSQQK 238
+E+ +E ++ ++ Q+
Sbjct: 1184 LREEQEKRRQERERQYREEEELQR 1207
Score = 28.1 bits (61), Expect = 9.2
Identities = 26/123 (21%), Positives = 52/123 (42%), Gaps = 15/123 (12%)
Query: 174 EQEYEKKLRAELVEKWKAEREARLARGEKEE--------EEE-------EEEEINIYAVT 218
E++ +++LR E + K E E R + E+ E EE E+EE +
Sbjct: 293 EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR 352
Query: 219 EEESDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEE 278
E+ +E Q+ + +++ + Q E+ L R +++ Q+ E + ++
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Query: 279 ARR 281
RR
Sbjct: 413 LRR 415
Score = 28.1 bits (61), Expect = 9.2
Identities = 34/143 (23%), Positives = 66/143 (46%), Gaps = 20/143 (13%)
Query: 143 PPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEK 202
P ++ R EL + Y +E++ L+QE E+ LR E EK + ERE + +
Sbjct: 1158 PEKRRRQELERQ-------YREEEE-----LQQEEEQLLREEQ-EKRRQERERQY---RE 1201
Query: 203 EEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFIAHVPVPSQQ---EIEEALVR-R 258
EEE + ++ Y ++ SD + E +++ + + + ++E++ +R R
Sbjct: 1202 EEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDR 1261
Query: 259 KKMELLQKYASETLQAQSEEARR 281
+ + LQ E + E+ RR
Sbjct: 1262 QSQQDLQHLLGEQQERDREQERR 1284
Score = 28.1 bits (61), Expect = 9.2
Identities = 23/115 (20%), Positives = 60/115 (52%), Gaps = 7/115 (6%)
Query: 173 LEQEYEKKLRAELVEKWKAEREARLARGEKEEE-EEEEEEINIYAVTEEESDEEGSQEKG 231
L++ E++LR + ++ E E +L R E+E + +EE+++ + + +EE +++
Sbjct: 1676 LQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQET 1735
Query: 232 GDDSQQKFIAHVPVPSQQEI----EEALVRRKKMELLQKYASETLQAQSEEARRL 282
+ ++ + + ++++ EE +RR++ + +K+ E Q E ++L
Sbjct: 1736 EQEQLRRQERYRKILEEEQLRPEREEQQLRRQERD--RKFREEEQLRQEREEQQL 1788
>gi|92859701 myosin VI [Homo sapiens]
Length = 1285
Score = 40.8 bits (94), Expect = 0.001
Identities = 32/139 (23%), Positives = 65/139 (46%), Gaps = 10/139 (7%)
Query: 146 KTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEE 205
K+ + I EY + + ++ L+++ +++ AE + + + E E R E++E+
Sbjct: 886 KSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEK 945
Query: 206 E--EEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMEL 263
+EEEE + E + +E + K +D +++ Q E+E L R+K+ E
Sbjct: 946 RRRKEEEERRMKLEMEAKRKQEEEERKKREDDEKRI--------QAEVEAQLARQKEEES 997
Query: 264 LQKYASETLQAQSEEARRL 282
Q+ E + E A R+
Sbjct: 998 QQQAVLEQERRDRELALRI 1016
>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
Length = 717
Score = 40.8 bits (94), Expect = 0.001
Identities = 32/110 (29%), Positives = 54/110 (49%), Gaps = 15/110 (13%)
Query: 176 EYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQ------- 228
E K+ A + E+E ++ R E+++ E+EE ++ A EEE +E G+Q
Sbjct: 276 EQINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKV---AQREEELEETGNQHNDVEIE 332
Query: 229 EKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEE 278
E G ++ ++ I H +QE EE +K E+ K ET +SE+
Sbjct: 333 EAGEEEEKEIAIVHSDAEKEQEEEE-----QKQEMEVKMEEETEVRESEK 377
Score = 32.7 bits (73), Expect = 0.37
Identities = 34/127 (26%), Positives = 59/127 (46%), Gaps = 15/127 (11%)
Query: 164 DEDDGVIVPLEQEYEKKLR----AELVEKWKAE-REARLARGEKEEEEEEEEEINIYAVT 218
++++G + E+E E+ E+ E + E +E + + E+E+EEEE+ V
Sbjct: 306 EQEEGKVAQREEELEETGNQHNDVEIEEAGEEEEKEIAIVHSDAEKEQEEEEQKQEMEVK 365
Query: 219 EEESDEEGSQEKGGDDSQQKFIAHV--------PVPSQQEIEEALVRRKKMELLQKYASE 270
EE E EK DSQ + + V V + QE+ E R + +E + AS+
Sbjct: 366 MEEETEVRESEK-QQDSQPEEVMDVLEMVENVKHVIADQEVMET-NRVESVEPSENEASK 423
Query: 271 TLQAQSE 277
L+ + E
Sbjct: 424 ELEPEME 430
>gi|34878777 ring finger protein 20 [Homo sapiens]
Length = 975
Score = 40.0 bits (92), Expect = 0.002
Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 1/89 (1%)
Query: 176 EYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDS 235
E + K E E+ + E+E R E+E+E+E E E +E+E D +EKG D
Sbjct: 559 EIKSKRDEEERERERREKERERER-EREKEKEREREKQKLKESEKERDSAKDKEKGKHDD 617
Query: 236 QQKFIAHVPVPSQQEIEEALVRRKKMELL 264
+K A + + E+++A +K+M+LL
Sbjct: 618 GRKKEAEIIKQLKIELKKAQESQKEMKLL 646
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 40.0 bits (92), Expect = 0.002
Identities = 36/149 (24%), Positives = 64/149 (42%), Gaps = 8/149 (5%)
Query: 134 ELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKAER 193
E+ EP+ PP + +KA++ L++D ++ +QE ++LR +L + + E
Sbjct: 574 EVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQ--EEEE 631
Query: 194 EARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEE 253
E +KE+ E A+ EEE+ ++SQ+ V S + +E
Sbjct: 632 EILRLHQQKEQSLSSLRERLQKAIEEEEA------RMREEESQRLSWLRAQVQSSTQADE 685
Query: 254 ALVRRKKMELLQKYASETLQAQSEEARRL 282
+R ++ LQK E Q E L
Sbjct: 686 DQIRAEQEASLQKLREELESQQKAERASL 714
Score = 28.9 bits (63), Expect = 5.4
Identities = 34/135 (25%), Positives = 58/135 (42%), Gaps = 20/135 (14%)
Query: 164 DEDDGVIVPLEQEYE-KKLRAELVEKWKAEREARLARG--------EKEEEEEEEEEINI 214
DED + EQE +KLR EL + KAER + + E+ E E+ E+ +
Sbjct: 684 DEDQ---IRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAAL 740
Query: 215 YAVTEEESDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEE-----ALVRRKKMELLQKYAS 269
A E+ + Q +G +++ +A + E+E R+ + LQK
Sbjct: 741 NAAKEKALQQLREQLEG---ERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQ 797
Query: 270 ETLQAQSEEARRLLG 284
E Q + + ++ LG
Sbjct: 798 EAQQKEEAQLQKCLG 812
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 40.0 bits (92), Expect = 0.002
Identities = 32/134 (23%), Positives = 60/134 (44%), Gaps = 5/134 (3%)
Query: 132 VRELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKA 191
V E+ E+ + + E + AI E + E+ ++E + E+ K
Sbjct: 453 VEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSP 512
Query: 192 ER----EARLARGEKEEEE-EEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFIAHVPVP 246
+ E + GEKEEEE +EEEE ++++E GS+++G + ++
Sbjct: 513 VKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETE 572
Query: 247 SQQEIEEALVRRKK 260
++ E EEA + +K
Sbjct: 573 AEAEGEEAEAKEEK 586
Score = 32.0 bits (71), Expect = 0.64
Identities = 29/112 (25%), Positives = 55/112 (49%), Gaps = 11/112 (9%)
Query: 172 PLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKG 231
P+E++ + + VE+ K++ E G+ E++EEEE+E+ A EE+ +++ + K
Sbjct: 673 PVEEKAKSPVPKSPVEEAKSKAEV----GKGEQKEEEEKEVK-EAPKEEKVEKKEEKPK- 726
Query: 232 GDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASE---TLQAQSEEAR 280
D +K A PV + E + + L+K E LQ + E+ +
Sbjct: 727 --DVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEK 776
Score = 30.4 bits (67), Expect = 1.9
Identities = 31/121 (25%), Positives = 55/121 (45%), Gaps = 18/121 (14%)
Query: 158 EYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAV 217
E G +E++G E+E ++ +++ E+ +E+E G E+EE E+EE A
Sbjct: 522 EEEGEKEEEEGQ--EEEEEEDEGAKSDQAEEGGSEKE-----GSSEKEEGEQEEGETEAE 574
Query: 218 TEEESDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSE 277
E E E ++K + S+ + +E LV K+E +K S ++ E
Sbjct: 575 AEGEEAEAKEEKKVEEKSE-----------EVATKEELVADAKVEKPEKAKSPVPKSPVE 623
Query: 278 E 278
E
Sbjct: 624 E 624
Score = 28.9 bits (63), Expect = 5.4
Identities = 43/144 (29%), Positives = 69/144 (47%), Gaps = 32/144 (22%)
Query: 137 EKEPLPPPR------KTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKLRA--ELVEK 188
EK P P+ K++AE+ K E +E + P E++ EKK ++ EK
Sbjct: 676 EKAKSPVPKSPVEEAKSKAEVGKGEQKEE----EEKEVKEAPKEEKVEKKEEKPKDVPEK 731
Query: 189 WKAE---REARLARG-----------EKEEEEE----EEEEINIYAVTEEESDEEGSQEK 230
KAE +E +A EKE +EE ++E+ A E S+EEGS +K
Sbjct: 732 KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGS-DK 790
Query: 231 GGDDSQQKFIA-HVPVPSQQEIEE 253
G S+++ IA + V ++E+E+
Sbjct: 791 GAKGSRKEDIAVNGEVEGKEEVEQ 814
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 40.0 bits (92), Expect = 0.002
Identities = 32/134 (23%), Positives = 60/134 (44%), Gaps = 5/134 (3%)
Query: 132 VRELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKA 191
V E+ E+ + + E + AI E + E+ ++E + E+ K
Sbjct: 77 VEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSP 136
Query: 192 ER----EARLARGEKEEEE-EEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFIAHVPVP 246
+ E + GEKEEEE +EEEE ++++E GS+++G + ++
Sbjct: 137 VKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETE 196
Query: 247 SQQEIEEALVRRKK 260
++ E EEA + +K
Sbjct: 197 AEAEGEEAEAKEEK 210
Score = 32.0 bits (71), Expect = 0.64
Identities = 29/112 (25%), Positives = 55/112 (49%), Gaps = 11/112 (9%)
Query: 172 PLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKG 231
P+E++ + + VE+ K++ E G+ E++EEEE+E+ A EE+ +++ + K
Sbjct: 297 PVEEKAKSPVPKSPVEEAKSKAEV----GKGEQKEEEEKEVK-EAPKEEKVEKKEEKPK- 350
Query: 232 GDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASE---TLQAQSEEAR 280
D +K A PV + E + + L+K E LQ + E+ +
Sbjct: 351 --DVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEK 400
Score = 30.4 bits (67), Expect = 1.9
Identities = 31/121 (25%), Positives = 55/121 (45%), Gaps = 18/121 (14%)
Query: 158 EYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAV 217
E G +E++G E+E ++ +++ E+ +E+E G E+EE E+EE A
Sbjct: 146 EEEGEKEEEEGQ--EEEEEEDEGAKSDQAEEGGSEKE-----GSSEKEEGEQEEGETEAE 198
Query: 218 TEEESDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSE 277
E E E ++K + S+ + +E LV K+E +K S ++ E
Sbjct: 199 AEGEEAEAKEEKKVEEKSE-----------EVATKEELVADAKVEKPEKAKSPVPKSPVE 247
Query: 278 E 278
E
Sbjct: 248 E 248
Score = 28.9 bits (63), Expect = 5.4
Identities = 43/144 (29%), Positives = 69/144 (47%), Gaps = 32/144 (22%)
Query: 137 EKEPLPPPR------KTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKLRA--ELVEK 188
EK P P+ K++AE+ K E +E + P E++ EKK ++ EK
Sbjct: 300 EKAKSPVPKSPVEEAKSKAEVGKGEQKEE----EEKEVKEAPKEEKVEKKEEKPKDVPEK 355
Query: 189 WKAE---REARLARG-----------EKEEEEE----EEEEINIYAVTEEESDEEGSQEK 230
KAE +E +A EKE +EE ++E+ A E S+EEGS +K
Sbjct: 356 KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGS-DK 414
Query: 231 GGDDSQQKFIA-HVPVPSQQEIEE 253
G S+++ IA + V ++E+E+
Sbjct: 415 GAKGSRKEDIAVNGEVEGKEEVEQ 438
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 40.0 bits (92), Expect = 0.002
Identities = 52/212 (24%), Positives = 91/212 (42%), Gaps = 22/212 (10%)
Query: 70 IRDLNDEINKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGYKYFGAAKDL 129
IRD +E ++ K H + K+ G D + + E +EVP G + ++
Sbjct: 289 IRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEP--SSIVNV 346
Query: 130 PG---VRELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKL----- 181
PG +R F + L K R+E ++ L E + L E +K++
Sbjct: 347 PGESTLRRDFLR--LQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKE 404
Query: 182 -RAELVEKWKAEREARLARGEKEEEEEEEEEINIYAV----TEEESDEEGSQEKGGDDSQ 236
R L E+ + EREAR + ++ E+EE+ + + EEE +EK + +
Sbjct: 405 QRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVERE 464
Query: 237 QKFIAHVPVPSQQEIEEALVRRKKMELLQKYA 268
Q++I Q E E+ + + +LLQ+ A
Sbjct: 465 QEYIRR-----QLEEEQRHLEVLQQQLLQEQA 491
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 40.0 bits (92), Expect = 0.002
Identities = 52/212 (24%), Positives = 91/212 (42%), Gaps = 22/212 (10%)
Query: 70 IRDLNDEINKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGYKYFGAAKDL 129
IRD +E ++ K H + K+ G D + + E +EVP G + ++
Sbjct: 289 IRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEP--SSIVNV 346
Query: 130 PG---VRELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKL----- 181
PG +R F + L K R+E ++ L E + L E +K++
Sbjct: 347 PGESTLRRDFLR--LQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKE 404
Query: 182 -RAELVEKWKAEREARLARGEKEEEEEEEEEINIYAV----TEEESDEEGSQEKGGDDSQ 236
R L E+ + EREAR + ++ E+EE+ + + EEE +EK + +
Sbjct: 405 QRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVERE 464
Query: 237 QKFIAHVPVPSQQEIEEALVRRKKMELLQKYA 268
Q++I Q E E+ + + +LLQ+ A
Sbjct: 465 QEYIRR-----QLEEEQRHLEVLQQQLLQEQA 491
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 40.0 bits (92), Expect = 0.002
Identities = 29/85 (34%), Positives = 43/85 (50%), Gaps = 11/85 (12%)
Query: 194 EARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFIAHVPVPSQQEIEE 253
E L + E+EEEEEEEEE EEE +EEG +E+GG + ++ QE EE
Sbjct: 1344 EDDLIKPEEEEEEEEEEE-------EEEEEEEGEEEEGGGNVEK----DPDGAKSQEKEE 1392
Query: 254 ALVRRKKMELLQKYASETLQAQSEE 278
+ +K + + E + + EE
Sbjct: 1393 PEISTEKEDSARLDDHEEEEEEDEE 1417
Score = 37.0 bits (84), Expect = 0.020
Identities = 26/85 (30%), Positives = 45/85 (52%), Gaps = 11/85 (12%)
Query: 182 RAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQQKFIA 241
R +L+E K E ++EEEEEEEEE EE+ +EE +E ++ +++ I
Sbjct: 1058 RGQLLELSKESSEEEEEEEDEEEEEEEEEE-------EEDEEEEEEEE---EEEEEENIQ 1107
Query: 242 HVPVPSQQEIEEALVRRKKMELLQK 266
P P + + ++RK+ +L+K
Sbjct: 1108 SSP-PRLTKPQSVAIKRKRPFVLKK 1131
Score = 30.8 bits (68), Expect = 1.4
Identities = 23/67 (34%), Positives = 32/67 (47%), Gaps = 4/67 (5%)
Query: 162 YLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEE 221
YL + V E+ +L E E+ + E + E+EEEE+EEEE EEE
Sbjct: 1045 YLHSPESRPVTGERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEE----EEEEEE 1100
Query: 222 SDEEGSQ 228
+EE Q
Sbjct: 1101 EEEENIQ 1107
Score = 28.1 bits (61), Expect = 9.2
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Query: 179 KKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEK 230
+K +L++ + E E E+EEEE EEEE E++ D SQEK
Sbjct: 1341 EKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGG--GNVEKDPDGAKSQEK 1390
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.132 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,956,491
Number of Sequences: 37866
Number of extensions: 669039
Number of successful extensions: 13944
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 350
Number of HSP's successfully gapped in prelim test: 479
Number of HSP's that attempted gapping in prelim test: 5837
Number of HSP's gapped (non-prelim): 4162
length of query: 285
length of database: 18,247,518
effective HSP length: 101
effective length of query: 184
effective length of database: 14,423,052
effective search space: 2653841568
effective search space used: 2653841568
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.