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Search of human proteins with 19923142
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923142 karyopherin beta 1 [Homo sapiens]
(876 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19923142 karyopherin beta 1 [Homo sapiens] 1729 0.0
gi|209969838 transportin 2 (importin 3, karyopherin beta 2b) iso... 120 6e-27
gi|209969836 transportin 2 (importin 3, karyopherin beta 2b) iso... 120 6e-27
gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isof... 120 6e-27
gi|23510381 transportin 1 isoform 2 [Homo sapiens] 118 2e-26
gi|133925811 transportin 1 isoform 1 [Homo sapiens] 118 2e-26
gi|24797086 importin 5 [Homo sapiens] 69 2e-11
gi|45331213 RAN binding protein 6 [Homo sapiens] 57 7e-08
gi|21361399 alpha isoform of regulatory subunit A, protein phosp... 41 0.004
gi|6912478 karyopherin alpha 6 [Homo sapiens] 40 0.009
gi|39812229 karyopherin alpha 5 [Homo sapiens] 40 0.012
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 39 0.028
gi|62460637 importin 4 [Homo sapiens] 39 0.028
gi|32455246 beta isoform of regulatory subunit A, protein phosph... 37 0.10
gi|32455244 beta isoform of regulatory subunit A, protein phosph... 37 0.10
gi|31415870 dedicator of cytokinesis 3 [Homo sapiens] 34 0.52
gi|214010175 CLIP-associating protein 1 isoform 3 [Homo sapiens] 34 0.68
gi|214010173 CLIP-associating protein 1 isoform 2 [Homo sapiens] 34 0.68
gi|31563537 CLIP-associating protein 1 isoform 1 [Homo sapiens] 34 0.68
gi|229090471 Tctex1 domain containing 2 [Homo sapiens] 33 1.2
gi|4759146 slit homolog 2 [Homo sapiens] 33 1.5
gi|197313662 leprecan-like 1 isoform b [Homo sapiens] 33 1.5
gi|27764882 leprecan-like 1 isoform a [Homo sapiens] 33 1.5
gi|7657530 rhabdoid tumor deletion region protein 1 [Homo sapiens] 32 2.0
gi|17402886 HEAT-like repeat-containing protein isoform 1 [Homo ... 32 3.4
gi|27477070 BTAF1 RNA polymerase II, B-TFIID transcription facto... 32 3.4
gi|239751742 PREDICTED: similar to zinc finger protein 181 [Homo... 31 4.4
gi|239751227 PREDICTED: hypothetical protein XP_002347761 [Homo ... 31 4.4
gi|239746243 PREDICTED: similar to zinc finger protein 181 [Homo... 31 4.4
gi|48255913 tripartite motif-containing 16 [Homo sapiens] 31 4.4
>gi|19923142 karyopherin beta 1 [Homo sapiens]
Length = 876
Score = 1729 bits (4477), Expect = 0.0
Identities = 876/876 (100%), Positives = 876/876 (100%)
Query: 1 MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ 60
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ
Sbjct: 1 MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ 60
Query: 61 IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE 120
IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE
Sbjct: 61 IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE 120
Query: 121 IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQG 180
IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQG
Sbjct: 121 IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQG 180
Query: 181 MRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN 240
MRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN
Sbjct: 181 MRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN 240
Query: 241 LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA 300
LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA
Sbjct: 241 LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA 300
Query: 301 AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE 360
AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE
Sbjct: 301 AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE 360
Query: 361 DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDP 420
DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDP
Sbjct: 361 DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDP 420
Query: 421 SVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA 480
SVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA
Sbjct: 421 SVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA 480
Query: 481 AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSA 540
AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSA
Sbjct: 481 AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSA 540
Query: 541 KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA 600
KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA
Sbjct: 541 KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA 600
Query: 601 LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKN 660
LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKN
Sbjct: 601 LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKN 660
Query: 661 YAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI 720
YAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI
Sbjct: 661 YAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI 720
Query: 721 ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQ 780
ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQ
Sbjct: 721 ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQ 780
Query: 781 ENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEAR 840
ENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEAR
Sbjct: 781 ENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEAR 840
Query: 841 PMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA 876
PMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA
Sbjct: 841 PMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA 876
>gi|209969838 transportin 2 (importin 3, karyopherin beta 2b)
isoform 1 [Homo sapiens]
Length = 897
Score = 120 bits (301), Expect = 6e-27
Identities = 172/794 (21%), Positives = 314/794 (39%), Gaps = 110/794 (13%)
Query: 2 ELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLAN-PGNSQVARVAAGLQ 60
+++ +L+ + SP+ Q L++ + P F L VL + R +GL
Sbjct: 12 QVLQLLKDSQSPNTATQRIVQDKLKQ--LNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLI 69
Query: 61 IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE 120
+KN+ +KA YQ + +K L +G SS + GI
Sbjct: 70 LKNN-------VKAHYQ----SFPPPVADFIKQECLNNIGDA----SSLIRATIGILITT 114
Query: 121 IP----VNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQD----IDPEQLQDKSNE 172
I + WPEL+PQL N+ N + + E A+ IC+D +D + L N
Sbjct: 115 IASKGELQMWPELLPQL-CNLLN-SEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNI 172
Query: 173 ILTAIIQGMRKEEPS-NNVKLAATNA-LLNSLEFTKANFDKESERHFIMQVVCEATQCPD 230
++ +Q + P + +A N +++ + N D E F + V D
Sbjct: 173 MIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAV------DDD 226
Query: 231 TRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDE- 289
VR + LV ++ + + +M ++ ++ + + VAL+ EFW + ++
Sbjct: 227 PEVRKNVCRALVMLLEVRIDRLIPHM-HSIIQYMLQRTQDHDENVALEACEFWLTLAEQP 285
Query: 290 ------------------------EMDLAIEASEAAEQGRPPEHTSKF---YAKGALQYL 322
E+D+ + + E P+ + K L
Sbjct: 286 ICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTL 345
Query: 323 VPILTQTLTKQDENDDDD-----DWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKN 377
+ +D DDDD DWN K + L +LA ++++PH+LP +K + +
Sbjct: 346 PHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFH 405
Query: 378 PDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICE 437
P+W +++ ++ G I EG + P + + +P LI+ + D +VR A WT+ R
Sbjct: 406 PEWVVKESGILVLGAIAEGCMQGMV-PYLPELIPHLIQCLSDKKALVRSIACWTLSRYAH 464
Query: 438 LLPEAAINDVYLAPLLQCLIEG-LSAEPRVASNVCWAFSSL-AEAAYEAADVADDQEEPA 495
+ D++L PL+ L++ L RV C AF++L EA E +
Sbjct: 465 WVVSQP-PDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTL 523
Query: 496 TYCLSSSFE---LIVQKLLETTDRPDGHQNNLRSSAYESLMEIV------KNSAKDCYPA 546
+ LI+ + T GH N + + ++ K+ KD +P
Sbjct: 524 VFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPL 583
Query: 547 VQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDV 606
++ + V ++S + + + +L+ TL + QH + + D
Sbjct: 584 LECLSSV-------ATALQSGFLPYCEPV-YQRCVTLVQKTLAQAMMYTQHPEQYEAPDK 635
Query: 607 -VMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQ 665
M L + A G + L+A S ++ +L + M+ P +
Sbjct: 636 DFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLL----FQCMQDSMP------------E 679
Query: 666 VCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIG 725
V ++ L+GDL +A ++ P E M +L NL E + SV G+I + +G
Sbjct: 680 VRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFI--SVCNNATWAIGEICMQMG 737
Query: 726 GEFKKYLEVVLNTL 739
E + Y+++VLN L
Sbjct: 738 AEMQPYVQMVLNNL 751
>gi|209969836 transportin 2 (importin 3, karyopherin beta 2b)
isoform 3 [Homo sapiens]
Length = 887
Score = 120 bits (301), Expect = 6e-27
Identities = 172/794 (21%), Positives = 314/794 (39%), Gaps = 110/794 (13%)
Query: 2 ELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLAN-PGNSQVARVAAGLQ 60
+++ +L+ + SP+ Q L++ + P F L VL + R +GL
Sbjct: 12 QVLQLLKDSQSPNTATQRIVQDKLKQ--LNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLI 69
Query: 61 IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE 120
+KN+ +KA YQ + +K L +G SS + GI
Sbjct: 70 LKNN-------VKAHYQ----SFPPPVADFIKQECLNNIGDA----SSLIRATIGILITT 114
Query: 121 IP----VNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQD----IDPEQLQDKSNE 172
I + WPEL+PQL N+ N + + E A+ IC+D +D + L N
Sbjct: 115 IASKGELQMWPELLPQL-CNLLN-SEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNI 172
Query: 173 ILTAIIQGMRKEEPS-NNVKLAATNA-LLNSLEFTKANFDKESERHFIMQVVCEATQCPD 230
++ +Q + P + +A N +++ + N D E F + V D
Sbjct: 173 MIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAV------DDD 226
Query: 231 TRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDE- 289
VR + LV ++ + + +M ++ ++ + + VAL+ EFW + ++
Sbjct: 227 PEVRKNVCRALVMLLEVRIDRLIPHM-HSIIQYMLQRTQDHDENVALEACEFWLTLAEQP 285
Query: 290 ------------------------EMDLAIEASEAAEQGRPPEHTSKF---YAKGALQYL 322
E+D+ + + E P+ + K L
Sbjct: 286 ICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTL 345
Query: 323 VPILTQTLTKQDENDDDD-----DWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKN 377
+ +D DDDD DWN K + L +LA ++++PH+LP +K + +
Sbjct: 346 PHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFH 405
Query: 378 PDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICE 437
P+W +++ ++ G I EG + P + + +P LI+ + D +VR A WT+ R
Sbjct: 406 PEWVVKESGILVLGAIAEGCMQGMV-PYLPELIPHLIQCLSDKKALVRSIACWTLSRYAH 464
Query: 438 LLPEAAINDVYLAPLLQCLIEG-LSAEPRVASNVCWAFSSL-AEAAYEAADVADDQEEPA 495
+ D++L PL+ L++ L RV C AF++L EA E +
Sbjct: 465 WVVSQP-PDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTL 523
Query: 496 TYCLSSSFE---LIVQKLLETTDRPDGHQNNLRSSAYESLMEIV------KNSAKDCYPA 546
+ LI+ + T GH N + + ++ K+ KD +P
Sbjct: 524 VFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPL 583
Query: 547 VQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDV 606
++ + V ++S + + + +L+ TL + QH + + D
Sbjct: 584 LECLSSV-------ATALQSGFLPYCEPV-YQRCVTLVQKTLAQAMMYTQHPEQYEAPDK 635
Query: 607 -VMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQ 665
M L + A G + L+A S ++ +L + M+ P +
Sbjct: 636 DFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLL----FQCMQDSMP------------E 679
Query: 666 VCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIG 725
V ++ L+GDL +A ++ P E M +L NL E + SV G+I + +G
Sbjct: 680 VRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFI--SVCNNATWAIGEICMQMG 737
Query: 726 GEFKKYLEVVLNTL 739
E + Y+++VLN L
Sbjct: 738 AEMQPYVQMVLNNL 751
>gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isoform
2 [Homo sapiens]
Length = 887
Score = 120 bits (301), Expect = 6e-27
Identities = 172/794 (21%), Positives = 314/794 (39%), Gaps = 110/794 (13%)
Query: 2 ELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLAN-PGNSQVARVAAGLQ 60
+++ +L+ + SP+ Q L++ + P F L VL + R +GL
Sbjct: 12 QVLQLLKDSQSPNTATQRIVQDKLKQ--LNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLI 69
Query: 61 IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE 120
+KN+ +KA YQ + +K L +G SS + GI
Sbjct: 70 LKNN-------VKAHYQ----SFPPPVADFIKQECLNNIGDA----SSLIRATIGILITT 114
Query: 121 IP----VNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQD----IDPEQLQDKSNE 172
I + WPEL+PQL N+ N + + E A+ IC+D +D + L N
Sbjct: 115 IASKGELQMWPELLPQL-CNLLN-SEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNI 172
Query: 173 ILTAIIQGMRKEEPS-NNVKLAATNA-LLNSLEFTKANFDKESERHFIMQVVCEATQCPD 230
++ +Q + P + +A N +++ + N D E F + V D
Sbjct: 173 MIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAV------DDD 226
Query: 231 TRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDE- 289
VR + LV ++ + + +M ++ ++ + + VAL+ EFW + ++
Sbjct: 227 PEVRKNVCRALVMLLEVRIDRLIPHM-HSIIQYMLQRTQDHDENVALEACEFWLTLAEQP 285
Query: 290 ------------------------EMDLAIEASEAAEQGRPPEHTSKF---YAKGALQYL 322
E+D+ + + E P+ + K L
Sbjct: 286 ICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTL 345
Query: 323 VPILTQTLTKQDENDDDD-----DWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKN 377
+ +D DDDD DWN K + L +LA ++++PH+LP +K + +
Sbjct: 346 PHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFH 405
Query: 378 PDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICE 437
P+W +++ ++ G I EG + P + + +P LI+ + D +VR A WT+ R
Sbjct: 406 PEWVVKESGILVLGAIAEGCMQGMV-PYLPELIPHLIQCLSDKKALVRSIACWTLSRYAH 464
Query: 438 LLPEAAINDVYLAPLLQCLIEG-LSAEPRVASNVCWAFSSL-AEAAYEAADVADDQEEPA 495
+ D++L PL+ L++ L RV C AF++L EA E +
Sbjct: 465 WVVSQP-PDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTL 523
Query: 496 TYCLSSSFE---LIVQKLLETTDRPDGHQNNLRSSAYESLMEIV------KNSAKDCYPA 546
+ LI+ + T GH N + + ++ K+ KD +P
Sbjct: 524 VFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPL 583
Query: 547 VQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDV 606
++ + V ++S + + + +L+ TL + QH + + D
Sbjct: 584 LECLSSV-------ATALQSGFLPYCEPV-YQRCVTLVQKTLAQAMMYTQHPEQYEAPDK 635
Query: 607 -VMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQ 665
M L + A G + L+A S ++ +L + M+ P +
Sbjct: 636 DFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLL----FQCMQDSMP------------E 679
Query: 666 VCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIG 725
V ++ L+GDL +A ++ P E M +L NL E + SV G+I + +G
Sbjct: 680 VRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFI--SVCNNATWAIGEICMQMG 737
Query: 726 GEFKKYLEVVLNTL 739
E + Y+++VLN L
Sbjct: 738 AEMQPYVQMVLNNL 751
>gi|23510381 transportin 1 isoform 2 [Homo sapiens]
Length = 890
Score = 118 bits (296), Expect = 2e-26
Identities = 179/798 (22%), Positives = 326/798 (40%), Gaps = 117/798 (14%)
Query: 2 ELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLAN-PGNSQVARVAAGLQ 60
+++ +L+++ SPD Q+ LE+ + P F L VL + R +GL
Sbjct: 14 QILQLLKESQSPDTTIQRTVQQKLEQ--LNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLI 71
Query: 61 IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE 120
+KN+ +KA +Q +K+ L +G + + + ++
Sbjct: 72 LKNN-------VKAHFQN----FPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASK 120
Query: 121 IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQD----IDPEQLQDKSNEILTA 176
+ WP+L+P+L + + + + + E A+ IC+D +D + L N ++
Sbjct: 121 GELQNWPDLLPKLCSLLDSEDY--NTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPK 178
Query: 177 IIQGMRKEEPS---------NNVKLAATNALLNSLEFTKANF-----DKESE-------- 214
+Q + P N ++ T AL+ ++ N D+E E
Sbjct: 179 FLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRA 238
Query: 215 ---------------RHFIMQVVCEATQCPDTRVRVAALQNLVKIMS--LYYQYMETYMG 257
H I++ + + TQ D V + A + + + + + ++
Sbjct: 239 LVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHL- 297
Query: 258 PALFAITIEAMK-SDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAK 316
P L + + MK SDID + L+G D E D I SE + RP H S+ A+
Sbjct: 298 PKLIPVLVNGMKYSDIDIILLKG--------DVEEDETIPDSE--QDIRPRFHRSRTVAQ 347
Query: 317 GALQYLVPILTQTLTKQDENDDDD---DWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKE 373
Q+ + + DE DDDD DWN K + L +LA D+++PH+LP +KE
Sbjct: 348 ---QHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKE 404
Query: 374 HIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVG 433
+ + +W +++ ++ G I EG + P + + +P LI+ + D +VR WT+
Sbjct: 405 LLFHHEWVVKESGILVLGAIAEGCMQGMI-PYLPELIPHLIQCLSDKKALVRSITCWTLS 463
Query: 434 RICELLPEAAINDVYLAPLLQCLIEG-LSAEPRVASNVCWAFSSL-AEAAYEAADVADDQ 491
R + D YL PL+ L++ L + RV C AF++L EA E
Sbjct: 464 RYAHWVVSQP-PDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYI 522
Query: 492 EEPATYCLSSSFE---LIVQKLLETTDRPDGHQNNLRSSAYESLM-------EIVKNSAK 541
+ + S LI+ + T GH N + + LM ++K+ K
Sbjct: 523 LDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLN-KPEYIQMLMPPLIQKWNMLKDEDK 581
Query: 542 DCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDAL 601
D +P ++ + V L + N +Q L + N + Q++
Sbjct: 582 DLFPLLECLSSVATALQSGFLPYCEPVYQRC----VNLVQKTLAQAMLNNAQPDQYE--A 635
Query: 602 QISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNY 661
D ++ +L + G GG E L+A S ++ ++ + M+ P
Sbjct: 636 PDKDFMIVALDLLSGLAEGLGGNIEQ-LVARSNILTLM----YQCMQDKMP--------- 681
Query: 662 AEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIA 721
+V ++ L+GDL +A ++ P + M +L NL E + SV G+I+
Sbjct: 682 ---EVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFI--SVCNNATWAIGEIS 736
Query: 722 LAIGGEFKKYLEVVLNTL 739
+ +G E + Y+ +VL+ L
Sbjct: 737 IQMGIEMQPYIPMVLHQL 754
>gi|133925811 transportin 1 isoform 1 [Homo sapiens]
Length = 898
Score = 118 bits (296), Expect = 2e-26
Identities = 179/798 (22%), Positives = 326/798 (40%), Gaps = 117/798 (14%)
Query: 2 ELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLAN-PGNSQVARVAAGLQ 60
+++ +L+++ SPD Q+ LE+ + P F L VL + R +GL
Sbjct: 22 QILQLLKESQSPDTTIQRTVQQKLEQ--LNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLI 79
Query: 61 IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE 120
+KN+ +KA +Q +K+ L +G + + + ++
Sbjct: 80 LKNN-------VKAHFQN----FPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASK 128
Query: 121 IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQD----IDPEQLQDKSNEILTA 176
+ WP+L+P+L + + + + + E A+ IC+D +D + L N ++
Sbjct: 129 GELQNWPDLLPKLCSLLDSEDY--NTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPK 186
Query: 177 IIQGMRKEEPS---------NNVKLAATNALLNSLEFTKANF-----DKESE-------- 214
+Q + P N ++ T AL+ ++ N D+E E
Sbjct: 187 FLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRA 246
Query: 215 ---------------RHFIMQVVCEATQCPDTRVRVAALQNLVKIMS--LYYQYMETYMG 257
H I++ + + TQ D V + A + + + + + ++
Sbjct: 247 LVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHL- 305
Query: 258 PALFAITIEAMK-SDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAK 316
P L + + MK SDID + L+G D E D I SE + RP H S+ A+
Sbjct: 306 PKLIPVLVNGMKYSDIDIILLKG--------DVEEDETIPDSE--QDIRPRFHRSRTVAQ 355
Query: 317 GALQYLVPILTQTLTKQDENDDDD---DWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKE 373
Q+ + + DE DDDD DWN K + L +LA D+++PH+LP +KE
Sbjct: 356 ---QHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKE 412
Query: 374 HIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVG 433
+ + +W +++ ++ G I EG + P + + +P LI+ + D +VR WT+
Sbjct: 413 LLFHHEWVVKESGILVLGAIAEGCMQGMI-PYLPELIPHLIQCLSDKKALVRSITCWTLS 471
Query: 434 RICELLPEAAINDVYLAPLLQCLIEG-LSAEPRVASNVCWAFSSL-AEAAYEAADVADDQ 491
R + D YL PL+ L++ L + RV C AF++L EA E
Sbjct: 472 RYAHWVVSQP-PDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYI 530
Query: 492 EEPATYCLSSSFE---LIVQKLLETTDRPDGHQNNLRSSAYESLM-------EIVKNSAK 541
+ + S LI+ + T GH N + + LM ++K+ K
Sbjct: 531 LDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLN-KPEYIQMLMPPLIQKWNMLKDEDK 589
Query: 542 DCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDAL 601
D +P ++ + V L + N +Q L + N + Q++
Sbjct: 590 DLFPLLECLSSVATALQSGFLPYCEPVYQRC----VNLVQKTLAQAMLNNAQPDQYE--A 643
Query: 602 QISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNY 661
D ++ +L + G GG E L+A S ++ ++ + M+ P
Sbjct: 644 PDKDFMIVALDLLSGLAEGLGGNIEQ-LVARSNILTLM----YQCMQDKMP--------- 689
Query: 662 AEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIA 721
+V ++ L+GDL +A ++ P + M +L NL E + SV G+I+
Sbjct: 690 ---EVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFI--SVCNNATWAIGEIS 744
Query: 722 LAIGGEFKKYLEVVLNTL 739
+ +G E + Y+ +VL+ L
Sbjct: 745 IQMGIEMQPYIPMVLHQL 762
>gi|24797086 importin 5 [Homo sapiens]
Length = 1115
Score = 68.6 bits (166), Expect = 2e-11
Identities = 109/479 (22%), Positives = 208/479 (43%), Gaps = 70/479 (14%)
Query: 6 ILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSL 65
+L +SPD + + A++ E ++ TFL++ R N ++ AR A + ++ L
Sbjct: 32 LLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIR---NTTAAEEARQMAAVLLRRLL 88
Query: 66 TSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAEIPV-- 123
+S + + + A+ ++ + +K+ +L + ET C A +
Sbjct: 89 SSA-------FDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELARNLIDE 141
Query: 124 ---NQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQG 180
NQWPE + L +V++ N ++E+ L I + I Q Q + I ++Q
Sbjct: 142 DGNNQWPEGLKFLFDSVSSQNVG--LREAALH-IFWNFPGIFGNQQQHYLDVIKRMLVQC 198
Query: 181 MRKEE-PS-NNVKLAATNALLNSLEFTKANFDKESERHF------IMQVVCEATQCPDTR 232
M+ +E PS + AT A + + E A F +HF +Q V ++ D
Sbjct: 199 MQDQEHPSIRTLSARATAAFILANEHNVALF-----KHFADLLPGFLQAVNDSCYQNDDS 253
Query: 233 VRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMD 292
V L++LV+I +Y+ ++ T++ + +L ++ ++
Sbjct: 254 V----LKSLVEIADTVPKYLRPHL-----EATLQLSLKLCGDTSLNNMQR-----QLALE 299
Query: 293 LAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDD--------DDDWNP 344
+ + SE A +HT+ + +P + + +E++D DDD++
Sbjct: 300 VIVTLSETAA-AMLRKHTN------IVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDS 352
Query: 345 CKAAGVCLMLLATCCEDDIVPHVLPFIKEHI----KNPDWRYRDAAVMAFGCILEGPEPS 400
AG + C + VLP IKEHI +NPDW+YR A +MA I EG
Sbjct: 353 NAVAGESALDRMACGLGGKL--VLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGCH-Q 409
Query: 401 QLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRIC-ELLP--EAAINDVYLAPLLQCL 456
Q++ ++ + + ++ ++DP VR A VG++ + P + ++ +A LLQ +
Sbjct: 410 QMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTM 468
Score = 45.4 bits (106), Expect = 2e-04
Identities = 41/191 (21%), Positives = 87/191 (45%), Gaps = 27/191 (14%)
Query: 581 QSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLG 640
+SLL L N+++ + L++ +++ G+ V E + +++++ +
Sbjct: 493 KSLLIPYLDNLVKHLHSIMVLKLQELIQK----------GTKLVLEQVVTSIASVADTAE 542
Query: 641 GEFLKYMEAFKPFLGIGLKNYAEYQV---------CLAAVGLVGDLCRALQSNIIPFCDE 691
+F+ Y + F P L ++N + ++ C++ +GL + +Q +
Sbjct: 543 EKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQD-----ASD 597
Query: 692 VMQLLLENLGNENVHRSVKPQI---LSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVD 748
VMQLLL+ + N PQI +S + + +G EF++YL VV+ L + + + +
Sbjct: 598 VMQLLLKTQTDFNDMEDDDPQISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPE 657
Query: 749 KSDYDMVDYLN 759
+ D D N
Sbjct: 658 VALLDTQDMEN 668
>gi|45331213 RAN binding protein 6 [Homo sapiens]
Length = 1105
Score = 57.0 bits (136), Expect = 7e-08
Identities = 138/683 (20%), Positives = 267/683 (39%), Gaps = 106/683 (15%)
Query: 2 ELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQI 61
E +L+ ++P + A++ E TFL++ R +V ++AA L +
Sbjct: 18 EFYQLLKNLINPSCMVRRQAEEIYENIPGLCKTTFLLDAVR--NRRAGYEVRQMAAAL-L 74
Query: 62 KNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQC-----VAGI 116
+ L+S +++ + + A+ +R+VK ++ + ET+ C +A
Sbjct: 75 RRLLSSG-------FEEVYPNLPADVQRDVKIELILAVKLETHASMRKKLCDIFAVLARN 127
Query: 117 ACAEIPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKS--NEIL 174
E N WPE + L+ ++ + N + E L + ++ D +L
Sbjct: 128 LIDEDGTNHWPEGLKFLIDSIYSKNVV--LWEVALHVFWHFPGIFGTQERHDLDIIKRLL 185
Query: 175 TAIIQGMRKEEPS-NNVKLAATNALLNSLEFTKANF-DKESERHFIMQVVCEATQCPDTR 232
IQ +E P+ + A A + + E A F D I+Q V ++ D
Sbjct: 186 DQCIQD--QEHPAIRTLSARAAAAFVLANENNIALFKDFADLLPGILQAVNDSCYQDDDS 243
Query: 233 VRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMD 292
V L++LV+I +Y+ Y+ L + L G SN+ +
Sbjct: 244 V----LESLVEIADTVPKYLGPYLEDTLQL-----------SLKLCGDSRLSNL---QRQ 285
Query: 293 LAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDEND-------DDDDWNPC 345
LA+E + P K + Q + IL + QD+ D ++DD++
Sbjct: 286 LALEVIVTLSETATP--MLKKHTNIIAQAVPHILAMMVDLQDDEDWVNADEMEEDDFDSN 343
Query: 346 KAAGVCLMLLATCCEDDIVPHVLPFIKEHI----KNPDWRYRDAAVMAFGCILEGPEPSQ 401
A + C V VLP KEHI ++PDW+YR A +MA I EG Q
Sbjct: 344 AVAAESALDRLACGLGGKV--VLPMTKEHIMQMLQSPDWKYRHAGLMALSAIGEGCH-QQ 400
Query: 402 LKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRIC-ELLP--EAAINDVYLAPLLQCLIE 458
++ ++ + + +++ ++DP VR A T+G++ + P + ++ +A LL+ +
Sbjct: 401 MESILDETVNSVLLFLQDPHPRVRAAACTTLGQMATDFAPNFQKKFHETVIAALLRTMEN 460
Query: 459 GLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPD 518
RV S+ A E C S L V +++
Sbjct: 461 --QGNQRVQSHAASALIIFIED-----------------CPKSLLVLYVDSMVK------ 495
Query: 519 GHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQ--------VLQMESHIQS 570
NL S L E+++N K + T + + +++ + HI
Sbjct: 496 ----NLHSVLVIKLQELIRNGTKLALEQLVTTIASVADTIEEKFVPYYDIFMPSLKHIVE 551
Query: 571 TSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQED--- 627
+ + + L+ + ++ V + +Q + VM LL+ + + +++D
Sbjct: 552 LAVQKELKLLRGKTIECISHIGLAVGKEKFMQDASNVMQLLLK---TQSDLNNMEDDDPQ 608
Query: 628 ---ALMAVSTLVEVLGGEFLKYM 647
+ A + + ++LG +F +Y+
Sbjct: 609 TSYMVSAWARMCKILGKDFQQYL 631
>gi|21361399 alpha isoform of regulatory subunit A, protein
phosphatase 2 [Homo sapiens]
Length = 589
Score = 41.2 bits (95), Expect = 0.004
Identities = 37/181 (20%), Positives = 75/181 (41%), Gaps = 13/181 (7%)
Query: 281 EFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDD 340
+++ N+C ++ + A+ A++ G E ++P+ + + D+
Sbjct: 168 QYFRNLCSDDTPMVRRAA-ASKLG---EFAKVLELDNVKSEIIPMFSNLAS------DEQ 217
Query: 341 DWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPS 400
D A C+ + ++D+ V+P +++ ++ WR R F + + P
Sbjct: 218 DSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPE 277
Query: 401 QLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGL 460
K ++ P LMKD VR A+ V CE L +V ++ +L C+ E +
Sbjct: 278 ITKTDLV---PAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELV 334
Query: 461 S 461
S
Sbjct: 335 S 335
>gi|6912478 karyopherin alpha 6 [Homo sapiens]
Length = 536
Score = 40.0 bits (92), Expect = 0.009
Identities = 31/105 (29%), Positives = 46/105 (43%), Gaps = 2/105 (1%)
Query: 373 EHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTV 432
E + + D++ A+ A G I+ G + L A+P L+ L+ P +R A WT+
Sbjct: 301 ELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTI 360
Query: 433 GRICELLPEAAINDVYLAPLLQCLIEGL-SAEPRVASNVCWAFSS 476
I A I V A + LIE L AE R WA ++
Sbjct: 361 SNI-TAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITN 404
Score = 34.3 bits (77), Expect = 0.52
Identities = 34/120 (28%), Positives = 53/120 (44%), Gaps = 12/120 (10%)
Query: 363 IVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQA--MPTLIELMKDP 420
+V + F+K +N + + A A I G SQ +VI+A +P IEL+
Sbjct: 125 VVDRFVEFLK---RNENCTLQFEAAWALTNIASGT--SQQTKIVIEAGAVPIFIELLNSD 179
Query: 421 SVVVRDTAAWTVGRIC---ELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSL 477
V++ A W +G I + + +N L PLL L + S + N WA S+L
Sbjct: 180 FEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTK--STRLTMTRNAVWALSNL 237
>gi|39812229 karyopherin alpha 5 [Homo sapiens]
Length = 539
Score = 39.7 bits (91), Expect = 0.012
Identities = 32/105 (30%), Positives = 46/105 (43%), Gaps = 2/105 (1%)
Query: 373 EHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTV 432
E + + D++ A+ A G I+ G + L A+P L+ L+ P +R A WTV
Sbjct: 304 ELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTV 363
Query: 433 GRICELLPEAAINDVYLAPLLQCLIEGL-SAEPRVASNVCWAFSS 476
I A I V A + LIE L AE R WA ++
Sbjct: 364 SNI-TAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITN 407
Score = 33.1 bits (74), Expect = 1.2
Identities = 27/99 (27%), Positives = 47/99 (47%), Gaps = 3/99 (3%)
Query: 383 RDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPS-VVVRDTAAWTVGRICELLPE 441
++ AV A G I + L + +P L+EL+ + + + A W + +C
Sbjct: 187 QEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRG-KN 245
Query: 442 AAINDVYLAPLLQCLIEGL-SAEPRVASNVCWAFSSLAE 479
N ++P L L L S++P V ++VCWA S L++
Sbjct: 246 PPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSD 284
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 38.5 bits (88), Expect = 0.028
Identities = 35/133 (26%), Positives = 69/133 (51%), Gaps = 17/133 (12%)
Query: 606 VVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKP-FLGIGLKNYAEY 664
V M +L+R+F+ + S + A++ + + LG + ++++ P FL +
Sbjct: 950 VSMVALMRIFRDQSLSHH-HTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNV-------I 1001
Query: 665 QVCLAAVG-----LVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGD 719
+VC A+ +G L ++S+I P+ DE++ L+ E ++ S++ I+ +
Sbjct: 1002 RVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWV---MNTSIQSTIILLIEQ 1058
Query: 720 IALAIGGEFKKYL 732
I +A+GGEFK YL
Sbjct: 1059 IVVALGGEFKLYL 1071
>gi|62460637 importin 4 [Homo sapiens]
Length = 1081
Score = 38.5 bits (88), Expect = 0.028
Identities = 51/218 (23%), Positives = 88/218 (40%), Gaps = 36/218 (16%)
Query: 518 DGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQF 577
DG +++R L++IV +D V+ L + + + LQ HI S S
Sbjct: 381 DGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQ--PHISSYS----- 433
Query: 578 NDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVE 637
++ LL A L++V H A A A+ VE
Sbjct: 434 REVMPLLLAYLKSVPLGHTHHLA--------------------------KACYALENFVE 467
Query: 638 VLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLL 697
LG + Y+ + L+N + + AV +G + A Q++++P+ +M+ L
Sbjct: 468 NLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEHLR 527
Query: 698 ENL--GNENVHRSVKPQILSVFGDIALAIGGEFKKYLE 733
E L G E++ + V+ Q L G +A A+G + E
Sbjct: 528 EFLLTGREDL-QPVQIQSLETLGVLARAVGEPMRPLAE 564
Score = 36.6 bits (83), Expect = 0.10
Identities = 28/135 (20%), Positives = 60/135 (44%), Gaps = 2/135 (1%)
Query: 347 AAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLV 406
A V ML + + P ++P ++E +++ R A ++ + +G + L+
Sbjct: 333 AVQVVDMLALHLPPEKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLL 392
Query: 407 IQAMPTLIELMKDPSVVVRDTAAWTVGRICE-LLPEAAINDVYLAPLLQCLIEGLS-AEP 464
+ + + ++DPS VVR+ A + +G+ E L P + + PLL ++ +
Sbjct: 393 PPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLLLAYLKSVPLGHT 452
Query: 465 RVASNVCWAFSSLAE 479
+ C+A + E
Sbjct: 453 HHLAKACYALENFVE 467
>gi|32455246 beta isoform of regulatory subunit A, protein
phosphatase 2 isoform a [Homo sapiens]
Length = 601
Score = 36.6 bits (83), Expect = 0.10
Identities = 29/119 (24%), Positives = 49/119 (41%), Gaps = 9/119 (7%)
Query: 322 LVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWR 381
+VP+ T + D+ D A C+ + +DD+ V+P +++ ++ WR
Sbjct: 217 IVPLFTSLAS------DEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWR 270
Query: 382 YRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLP 440
R F + + P K + +P L+KD VR AA V + E LP
Sbjct: 271 VRYMVADRFSELQKAMGP---KITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLP 326
>gi|32455244 beta isoform of regulatory subunit A, protein
phosphatase 2 isoform b [Homo sapiens]
Length = 667
Score = 36.6 bits (83), Expect = 0.10
Identities = 29/119 (24%), Positives = 49/119 (41%), Gaps = 9/119 (7%)
Query: 322 LVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWR 381
+VP+ T + D+ D A C+ + +DD+ V+P +++ ++ WR
Sbjct: 217 IVPLFTSLAS------DEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWR 270
Query: 382 YRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLP 440
R F + + P K + +P L+KD VR AA V + E LP
Sbjct: 271 VRYMVADRFSELQKAMGP---KITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLP 326
>gi|31415870 dedicator of cytokinesis 3 [Homo sapiens]
Length = 2030
Score = 34.3 bits (77), Expect = 0.52
Identities = 36/169 (21%), Positives = 78/169 (46%), Gaps = 21/169 (12%)
Query: 561 VLQMESHIQSTSDRI-QFNDLQSLLC-ATLQNVLRKVQHQDALQISDVVMASLLRMFQST 618
V++++S ++ R+ F++ + +L L ++ ++ Q L I ++ S+ + +++
Sbjct: 831 VVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILGSIFSIVKTS 890
Query: 619 AGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQV-------CLAAV 671
+ V E+ M V +L++VL + L I K++A+ V C A +
Sbjct: 891 SLEADVMEEVEMMVESLLDVL----------LQTLLTIMSKSHAQEAVRGQRCPQCTAEI 940
Query: 672 GLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI 720
G+ L S + CD Q LL+N +++ + +I VF ++
Sbjct: 941 --TGEYVSCLLSLLRQMCDTHFQHLLDNFQSKDELKEFLLKIFCVFRNL 987
>gi|214010175 CLIP-associating protein 1 isoform 3 [Homo sapiens]
Length = 1471
Score = 33.9 bits (76), Expect = 0.68
Identities = 53/226 (23%), Positives = 92/226 (40%), Gaps = 27/226 (11%)
Query: 160 DIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATN-ALLNSLEFTKANFDKESERHF- 217
D D EQL+D + + ++ + KE ++N ++ ALL L+ T+ + E HF
Sbjct: 1220 DDDMEQLRDVPIDH-SDLVADLLKELSNHNERVEERKGALLELLKITREDSLGVWEEHFK 1278
Query: 218 -IMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVA 276
I+ ++ E D +R AL+ L +I+ + Y + T+EA K EV
Sbjct: 1279 TILLLLLETLGDKDHSIRALALRVLREILRNQPARFKNYAELTIMK-TLEAHKDSHKEVV 1337
Query: 277 LQGIEFWSNVCD---------------EEMDLAIEASEAAEQGRPPEHTSKFYAKGALQY 321
E S + + D I + Q + E +K + LQ
Sbjct: 1338 RAAEEAASTLASSIHPEQCIKVLCPIIQTADYPINLAAIKMQTKVVERIAK---ESLLQL 1394
Query: 322 LVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHV 367
LV I+ L D + + KA+ CL+ + + +D+ PH+
Sbjct: 1395 LVDIIPGLLQGYDNTES----SVRKASVFCLVAIYSVIGEDLKPHL 1436
>gi|214010173 CLIP-associating protein 1 isoform 2 [Homo sapiens]
Length = 1479
Score = 33.9 bits (76), Expect = 0.68
Identities = 53/226 (23%), Positives = 92/226 (40%), Gaps = 27/226 (11%)
Query: 160 DIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATN-ALLNSLEFTKANFDKESERHF- 217
D D EQL+D + + ++ + KE ++N ++ ALL L+ T+ + E HF
Sbjct: 1228 DDDMEQLRDVPIDH-SDLVADLLKELSNHNERVEERKGALLELLKITREDSLGVWEEHFK 1286
Query: 218 -IMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVA 276
I+ ++ E D +R AL+ L +I+ + Y + T+EA K EV
Sbjct: 1287 TILLLLLETLGDKDHSIRALALRVLREILRNQPARFKNYAELTIMK-TLEAHKDSHKEVV 1345
Query: 277 LQGIEFWSNVCD---------------EEMDLAIEASEAAEQGRPPEHTSKFYAKGALQY 321
E S + + D I + Q + E +K + LQ
Sbjct: 1346 RAAEEAASTLASSIHPEQCIKVLCPIIQTADYPINLAAIKMQTKVVERIAK---ESLLQL 1402
Query: 322 LVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHV 367
LV I+ L D + + KA+ CL+ + + +D+ PH+
Sbjct: 1403 LVDIIPGLLQGYDNTES----SVRKASVFCLVAIYSVIGEDLKPHL 1444
>gi|31563537 CLIP-associating protein 1 isoform 1 [Homo sapiens]
Length = 1538
Score = 33.9 bits (76), Expect = 0.68
Identities = 53/226 (23%), Positives = 92/226 (40%), Gaps = 27/226 (11%)
Query: 160 DIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATN-ALLNSLEFTKANFDKESERHF- 217
D D EQL+D + + ++ + KE ++N ++ ALL L+ T+ + E HF
Sbjct: 1287 DDDMEQLRDVPIDH-SDLVADLLKELSNHNERVEERKGALLELLKITREDSLGVWEEHFK 1345
Query: 218 -IMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVA 276
I+ ++ E D +R AL+ L +I+ + Y + T+EA K EV
Sbjct: 1346 TILLLLLETLGDKDHSIRALALRVLREILRNQPARFKNYAELTIMK-TLEAHKDSHKEVV 1404
Query: 277 LQGIEFWSNVCD---------------EEMDLAIEASEAAEQGRPPEHTSKFYAKGALQY 321
E S + + D I + Q + E +K + LQ
Sbjct: 1405 RAAEEAASTLASSIHPEQCIKVLCPIIQTADYPINLAAIKMQTKVVERIAK---ESLLQL 1461
Query: 322 LVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHV 367
LV I+ L D + + KA+ CL+ + + +D+ PH+
Sbjct: 1462 LVDIIPGLLQGYDNTES----SVRKASVFCLVAIYSVIGEDLKPHL 1503
>gi|229090471 Tctex1 domain containing 2 [Homo sapiens]
Length = 142
Score = 33.1 bits (74), Expect = 1.2
Identities = 20/83 (24%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 84 DANARREVKNYVLQTLGTETYRPSSASQCVAGIACAEIPVNQW-PELIPQLVANVTNPNS 142
+ NA Y+L+ + + +RPS C+ + E+ ++ PE +PQL +++ N
Sbjct: 19 EKNAGEPENTYILRPVFQQRFRPSVVKDCIHAVLKEELANAEYSPEEMPQLTKHLSE-NI 77
Query: 143 TEHMKESTLEAIGYICQDIDPEQ 165
+ +KE + + Q + EQ
Sbjct: 78 KDKLKEMGFDRYKMVVQVVIGEQ 100
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 32.7 bits (73), Expect = 1.5
Identities = 33/114 (28%), Positives = 49/114 (42%), Gaps = 18/114 (15%)
Query: 100 GTETYRPSSASQCVAGIACAE-------------IPVNQWPELIPQLVANVTNPNSTEHM 146
GTE YR + C A +AC E +N+ PE IPQ A + N+
Sbjct: 488 GTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNN---- 543
Query: 147 KESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLN 200
+ + LEA G I + + + + SN +T I +G + N L +N L N
Sbjct: 544 EFTVLEATG-IFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 596
>gi|197313662 leprecan-like 1 isoform b [Homo sapiens]
Length = 527
Score = 32.7 bits (73), Expect = 1.5
Identities = 23/101 (22%), Positives = 46/101 (45%), Gaps = 7/101 (6%)
Query: 206 KANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYME-TYMGPALFAIT 264
KA + H++ +VC+ + R L + + L+Y Y++ Y +
Sbjct: 85 KAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKA 144
Query: 265 IEAMKSDI-----DEVALQGIEFWSNVCDEEMDLA-IEASE 299
+E K+ + DE L ++++ ++ D+ +D A IEA E
Sbjct: 145 LECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEARE 185
>gi|27764882 leprecan-like 1 isoform a [Homo sapiens]
Length = 708
Score = 32.7 bits (73), Expect = 1.5
Identities = 23/101 (22%), Positives = 46/101 (45%), Gaps = 7/101 (6%)
Query: 206 KANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYME-TYMGPALFAIT 264
KA + H++ +VC+ + R L + + L+Y Y++ Y +
Sbjct: 266 KAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKA 325
Query: 265 IEAMKSDI-----DEVALQGIEFWSNVCDEEMDLA-IEASE 299
+E K+ + DE L ++++ ++ D+ +D A IEA E
Sbjct: 326 LECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEARE 366
>gi|7657530 rhabdoid tumor deletion region protein 1 [Homo sapiens]
Length = 348
Score = 32.3 bits (72), Expect = 2.0
Identities = 25/75 (33%), Positives = 39/75 (52%), Gaps = 9/75 (12%)
Query: 368 LPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVR-- 425
LP +KE +++ D + R A+MA ++ PE K + I M L L+KD + +VR
Sbjct: 28 LPKLKEELQSEDLQTRQKALMALCDLMHDPE-CIYKAMNIGCMENLKALLKDSNSMVRIK 86
Query: 426 ------DTAAWTVGR 434
TA+ +VGR
Sbjct: 87 TTEVLHITASHSVGR 101
>gi|17402886 HEAT-like repeat-containing protein isoform 1 [Homo
sapiens]
Length = 873
Score = 31.6 bits (70), Expect = 3.4
Identities = 39/178 (21%), Positives = 77/178 (43%), Gaps = 25/178 (14%)
Query: 85 ANARREVKNYVLQTLGTETYRPSSASQCVAGIACAEIPVNQWPELIP-QLVANVTNPNST 143
+NA E V++ L ET R + V+ A++ L+ +++ +TN
Sbjct: 150 SNAWLETLLSVIEVLPKETLRHEILNPLVSK---AQLSQTVQSRLVSCKILGKLTNKFDA 206
Query: 144 EHMKESTLEAIGYICQDIDPE-------QLQDKSNEILTAIIQGM-------RKEEPSNN 189
+K L + +CQD++ E QL++ + I T + + + + ++
Sbjct: 207 HTIKREILPLVKSLCQDVEYEVRSCMCRQLENIAQGIGTELTKSVVLPELIELSRDEGSS 266
Query: 190 VKLAATNALLNSLEFTKANFDKESERHFIMQVV---CEATQCPDTRVRVAALQNLVKI 244
V+LAA L+N L+ FD + I+ +V CE + D + ++ +L K+
Sbjct: 267 VRLAAFETLVNLLDI----FDTDDRSQTILPLVKSFCEKSFKADESILISLSFHLGKL 320
>gi|27477070 BTAF1 RNA polymerase II, B-TFIID transcription
factor-associated, 170kDa [Homo sapiens]
Length = 1849
Score = 31.6 bits (70), Expect = 3.4
Identities = 19/57 (33%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 400 SQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCL 456
S+L PL++Q +P L ++ PS VR AA VG + ++ +N ++L +L L
Sbjct: 1098 SELHPLLVQHLPHLYMCLQYPSTAVRHMAARCVGVMSKIATMETMN-IFLEKVLPWL 1153
>gi|239751742 PREDICTED: similar to zinc finger protein 181 [Homo
sapiens]
Length = 452
Score = 31.2 bits (69), Expect = 4.4
Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 4/74 (5%)
Query: 382 YRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPE 441
Y+D V + ++ S KP VI TL+E K+P +V + + + I + P
Sbjct: 44 YKDVMVQNYENLVSVAGLSITKPYVI----TLLEHGKEPWMVEKKLSKVYILPISVITPA 99
Query: 442 AAINDVYLAPLLQC 455
+++N V+ AP C
Sbjct: 100 SSVNSVFSAPFEHC 113
>gi|239751227 PREDICTED: hypothetical protein XP_002347761 [Homo
sapiens]
Length = 282
Score = 31.2 bits (69), Expect = 4.4
Identities = 18/62 (29%), Positives = 28/62 (45%), Gaps = 9/62 (14%)
Query: 340 DDWNPCKAAGVCLMLLATCCEDDIVPHVL------PFIKEHIKNPDWRY---RDAAVMAF 390
DD KA CL + CE+ + PH + + E +K+ +WRY + + AF
Sbjct: 82 DDTRRVKAVKSCLTCMVNYCEEHLQPHQVNIKLQSHLLTEPVKDHNWRYCPAHHSPLSAF 141
Query: 391 GC 392
C
Sbjct: 142 CC 143
>gi|239746243 PREDICTED: similar to zinc finger protein 181 [Homo
sapiens]
Length = 442
Score = 31.2 bits (69), Expect = 4.4
Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 4/74 (5%)
Query: 382 YRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPE 441
Y+D V + ++ S KP VI TL+E K+P +V + + + I + P
Sbjct: 34 YKDVMVQNYENLVSVAGLSITKPYVI----TLLEHGKEPWMVEKKLSKVYILPISVITPA 89
Query: 442 AAINDVYLAPLLQC 455
+++N V+ AP C
Sbjct: 90 SSVNSVFSAPFEHC 103
>gi|48255913 tripartite motif-containing 16 [Homo sapiens]
Length = 564
Score = 31.2 bits (69), Expect = 4.4
Identities = 18/62 (29%), Positives = 28/62 (45%), Gaps = 9/62 (14%)
Query: 340 DDWNPCKAAGVCLMLLATCCEDDIVPHVL------PFIKEHIKNPDWRY---RDAAVMAF 390
DD KA CL + CE+ + PH + + E +K+ +WRY + + AF
Sbjct: 82 DDTRRVKAVKSCLTCMVNYCEEHLQPHQVNIKLQSHLLTEPVKDHNWRYCPAHHSPLSAF 141
Query: 391 GC 392
C
Sbjct: 142 CC 143
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,193,377
Number of Sequences: 37866
Number of extensions: 1249411
Number of successful extensions: 3614
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 3524
Number of HSP's gapped (non-prelim): 114
length of query: 876
length of database: 18,247,518
effective HSP length: 111
effective length of query: 765
effective length of database: 14,044,392
effective search space: 10743959880
effective search space used: 10743959880
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.